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Sample records for juvenile-to-adult antler development

  1. Stem cells responsible for deer antler regeneration are unable to recapitulate the process of first antler development-revealed through intradermal and subcutaneous tissue transplantation.

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    Li, Chunyi; Yang, Fuhe; Haines, Stephen; Zhao, Haiping; Wang, Wenying; Xing, Xiumei; Sun, Hongmei; Chu, Wenhui; Lu, Xiaoping; Liu, Linling; McMahon, Chris

    2010-11-15

    Antlers offer a unique model for the study of whether regeneration recapitulates development in a mammalian organ. Research, to date, supports the full recapitulation in antler, but a recent report that subcutaneously transplanted (ST) pedicle periosteum (PP) failed to induce that ectopic antler formation could argue against recapitulation, as antlerogenic periosteum (AP) can readily do so. However, it was not clear in that study whether the result was caused by inability of the PP to interact with the skin or owing to failure to create the required close contact to it. This study was designed to clarify this uncertainty by adopting intradermal transplantation (IT) to achieve the required close contact without the need for significant mass expansion. The results showed that IT of 1/8 of the original AP mass or more was sufficient for antler induction, whereas ST of 1/4-AP or less could not do so within 2 years. The minimum amount of AP required for antler induction using the IT approach was somewhere between 1/8 and 1/12-AP (development. It is likely that PP has been restricted for antler regeneration and lost the potential to initiate antler development.

  2. Antler development in reindeer in relation to age and sex

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    Amund Høymork

    2002-06-01

    Full Text Available Yearling male and adult female reindeer (Rangifer tarandus tarandus are similar in size and shape. If sexual clues are hidden, it can be difficult to distinguish between them. Antlers can be a useful aid in classifying yearling males and adult females, depending on whether specific antler characteristics are identifiable for these two groups. We recorded antler characteristics in a domestic reindeer herd (Vågå and found considerable overlap in antler height, width and circumference between the different age and sex groups. Total tines and number of tine split-offs are use¬ful for the field biologist when discriminating among adult females, yearling males and 2.5 year-old males. For example, when using the tine split-offs with the suggested classification, 79% of the observed adult females and 76% of the yearling males were classified correctly. The antler height, width and circumference provide other biological dif¬ferences between groups, but are not easy to use to identify free ranging reindeer. This is due to the great overlap in antler size between the groups and measuring difficulties in a field study situation. Male and female calves have very similar antlers, and only the antler width is possible for sex discrimination, giving 67% accuracy of discriminating between these two groups.

  3. Iodine distribution in the environment as a limiting factor for roe deer antler development.

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    Lehoczki, Róbert; Erdélyi, Károly; Sonkoly, Krisztina; Szemethy, László; Csányi, Sándor

    2011-02-01

    The iodine-containing hormones produced by the thyroid gland play a role in the complex neuro-hormonal regulation of antler development. The proper function of the thyroid depends on the adequate iodine supply of the organism, which is directly related to the iodine content of food and drinking water. The purpose of this study was to explore the connection between the iodine content of the water base, which has a strong correlation with the iodine concentration of environmental components available to animals, and the antler weight of roe deer (Capreolus capreolus) shot in Hungarian hunting areas. Using a general linear model, controlling for the collective effects of other environmental factors (deer population density, harvest rate, land use, and soil fertility information), the iodine content of the water base explained 51.4% of the total variance of antler weights. The results suggest that antler weights increase with increasing iodine concentration regardless of other factors; thus, the environmental iodine distribution can be a limiting factor suppressing roe deer performance assessed here as antler weight. Further experimental studies of controlled iodine uptake are needed to define the exact physiological iodine requirements of roe deer bucks.

  4. Identification of transcription factors potentially involved in the juvenile to adult phase transition in Citrus.

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    Castillo, Mari-Cruz; Forment, Javier; Gadea, José; Carrasco, Jose Luis; Juarez, José; Navarro, Luís; Ancillo, Gema

    2013-11-01

    The juvenile to adult transition (JAT) in higher plants is required for them to reach reproductive competence. However, it is a poorly understood process in woody plants, where only a few genes have been definitely identified as being involved in this transition. This work aims at increasing our understanding of the mechanisms regulating the JAT in citrus. Juvenile and adult plants from Pineapple sweet orange (Citrus sinensis) and Rough lemon (C. jambhiri) were used to screen for differentially expressed transcription factors (TFs) using a 1·15K microarray developed on the basis of the CitrusTF database. Murcott tangor (C. reticulata × C. sinensis) and Duncan grapefruit (C. paradisi) were incorporated into the quantitative real-time reverse transcription-PCR validation in order to select those genes whose phase-specific regulation was common to the four species. A browsable web database has been created with information about the structural and functional annotation related to 1152 unigenes of putative citrus TFs (CTFs). This database constitutes a valuable resource for research on transcriptional regulation and comparative genomics. Moreover, a microarray has been developed and used that contains these putative CTFs, in order to identify eight genes that showed differential expression in juvenile and adult meristems of four different species of citrus. Those genes have been characterized, and their expression pattern in vegetative and reproductive tissues has been analysed. Four of them are MADS-box genes, a family of TFs involved in developmental processes, whereas another one resembles MADS-box genes but lacks the MADS box itself. The other three showed high partial sequence similarity restricted to specific Arabidopsis protein domains but negligible outside those domains. The work presented here indicates that the JAT in citrus could be controlled by mechanisms that are in part common to those of Arabidopsis, but also somehow different, since specific factors

  5. The Effects of Elk Velvet Antler Dietary Supplementation on Physical Growth and Bone Development in Growing Rats

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    Jiongran Chen

    2015-01-01

    Full Text Available Elk velvet antler (EVA has been used in traditional Oriental medicine for centuries to promote general health; however, little evidence for its effect on bone development is available. We investigated the effects of lifelong exposure of Wistar rats to a diet containing 10% EVA on physical growth and bone development. Measurements included weekly body weights, blood chemistry and kidney and testis/ovary indices (sacrificed at 5, 9, or 16 weeks of age, and bone traits of the femur bones by peripheral quantitative computed tomography (pQCT. Mean body weights were higher in the EVA group at 4–8 weeks in males and at 5 weeks of age in females. The kidney indices were greater in EVA dietary supplemented male rats at 5 and 16 weeks of age, in females at 16 weeks of age, and testis/ovary indices at 5 weeks of age. The femoral length was increased in both males and females at 5 weeks, and several pQCT-measured parameters had increased in EVA males and females. The activity of alkaline phosphatase (ALP increased in EVA group while the content of calcium and phosphorus did not differ among groups. Our results seem to support a role for dietary supplementation of EVA on growth and bone development in this model.

  6. The Effects of Elk Velvet Antler Dietary Supplementation on Physical Growth and Bone Development in Growing Rats.

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    Chen, Jiongran; Yang, Yanfei; Abbasi, Sepideh; Hajinezhad, Daryoush; Kontulainen, Saija; Honaramooz, Ali

    2015-01-01

    Elk velvet antler (EVA) has been used in traditional Oriental medicine for centuries to promote general health; however, little evidence for its effect on bone development is available. We investigated the effects of lifelong exposure of Wistar rats to a diet containing 10% EVA on physical growth and bone development. Measurements included weekly body weights, blood chemistry and kidney and testis/ovary indices (sacrificed at 5, 9, or 16 weeks of age), and bone traits of the femur bones by peripheral quantitative computed tomography (pQCT). Mean body weights were higher in the EVA group at 4-8 weeks in males and at 5 weeks of age in females. The kidney indices were greater in EVA dietary supplemented male rats at 5 and 16 weeks of age, in females at 16 weeks of age, and testis/ovary indices at 5 weeks of age. The femoral length was increased in both males and females at 5 weeks, and several pQCT-measured parameters had increased in EVA males and females. The activity of alkaline phosphatase (ALP) increased in EVA group while the content of calcium and phosphorus did not differ among groups. Our results seem to support a role for dietary supplementation of EVA on growth and bone development in this model.

  7. Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans.

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    Herrera, R Antonio; Kiontke, Karin; Fitch, David H A

    2016-03-01

    The heterochronic genes lin-28, let-7 and lin-41 regulate fundamental developmental transitions in animals, such as stemness versus differentiation and juvenile versus adult states. We identify a new heterochronic gene, lep-2, in Caenorhabditis elegans. Mutations in lep-2 cause a delay in the juvenile-to-adult transition, with adult males retaining pointed, juvenile tail tips, and displaying defective sexual behaviors. In both sexes, lep-2 mutants fail to cease molting or produce an adult cuticle. We find that LEP-2 post-translationally regulates LIN-28 by promoting LIN-28 protein degradation. lep-2 encodes the sole C. elegans ortholog of the Makorin (Mkrn) family of proteins. Like lin-28 and other heterochronic pathway members, vertebrate Mkrns are involved in developmental switches, including the timing of pubertal onset in humans. Based on shared roles, conservation and the interaction between lep-2 and lin-28 shown here, we propose that Mkrns, together with other heterochronic genes, constitute an evolutionarily ancient conserved module regulating switches in development.

  8. Seasonal variations in red deer (Cervus elaphus) hematology related to antler growth and biometrics measurements.

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    Gaspar-López, Enrique; Landete-Castillejos, Tomás; Estevez, Jose Antonio; Ceacero, Francisco; Gallego, Laureano; García, Andrés Jose

    2011-04-01

    The aim of the study was to relate seasonal hematology changes with the rest of physiological variations suffered by red deer, such as antler and biometrics cycle, and to assess the relationship between hematology and the effort performed in antler development. Blood samples were taken from 21 male red deer every 4 weeks during 18 months. Samples were analyzed for the main hematological parameters. Simultaneously, biometrics measurements were taken, such as antler length, body weight, body condition score, testicular diameter (TD), and thoracic and neck girth. All the blood cell types (erythrocytes, leukocytes, and platelets) showed seasonal variations, increasing as antler cleaning approached, as did hematocrit and hemoglobin. The final size of antlers was negatively related to leukocyte count, nonlymphoid leukocyte count, red cell distribution width, mean corpuscular hemoglobin, mean platelet volume, and TD, whereas it was positively related to body condition during antler growth. Huge seasonal variations in some hematological values have been found to be related to changes in antler and biometrics measurements. Since these variations are even greater than the caused by deer handling, they should be taken into account when evaluating hematology in deer populations.

  9. Research on the relationship between the elements and pharmacological activities in velvet antler using factor analysis and cluster analysis

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    Zhou, Libing

    2017-04-01

    relation development of velvet antler resources as well as the relationship between the elements and traditional Chinese medicine efficacy for the human.

  10. Improbable appendages: Deer antler renewal as a unique case of mammalian regeneration.

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    Kierdorf, Uwe; Li, Chunyi; Price, Joanna S

    2009-07-01

    Deer antlers are periodically replaced cranial appendages that develop from permanent outgrowths of the frontal bones known as pedicles. Antler re-growth is a unique regenerative event in mammals which in general are unable to replace bony appendages. Recent evidence suggests that antler regeneration is a stem cell-based process that depends on the activation of stem cells located in the pedicle periosteum which are presumed to be neural crest-derived. It has been demonstrated that several developmental pathways are involved in antler regeneration that are also known to play a role in the control of skeletal development and regeneration in other vertebrates. However, in contrast to most other natural examples of regeneration of complete body structures, antler regeneration apparently neither depends on a functional nerve supply nor involves a direct contact between wound epithelium and mesenchymal tissue. Antlers thus demonstrate that regeneration of a large bony appendage in a mammal can be achieved by a process that differs in certain aspects from epimorphic regeneration in lower vertebrates.

  11. Deer antler regeneration: cells, concepts, and controversies.

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    Kierdorf, Uwe; Kierdorf, Horst; Szuwart, Thomas

    2007-08-01

    The periodic replacement of antlers is an exceptional regenerative process in mammals, which in general are unable to regenerate complete body appendages. Antler regeneration has traditionally been viewed as an epimorphic process closely resembling limb regeneration in urodele amphibians, and the terminology of the latter process has also been applied to antler regeneration. More recent studies, however, showed that, unlike urodele limb regeneration, antler regeneration does not involve cell dedifferentiation and the formation of a blastema from these dedifferentiated cells. Rather, these studies suggest that antler regeneration is a stem-cell-based process that depends on the periodic activation of, presumably neural-crest-derived, periosteal stem cells of the distal pedicle. The evidence for this hypothesis is reviewed and as a result, a new concept of antler regeneration as a process of stem-cell-based epimorphic regeneration is proposed that does not involve cell dedifferentiation or transdifferentiation. Antler regeneration illustrates that extensive appendage regeneration in a postnatal mammal can be achieved by a developmental process that differs in several fundamental aspects from limb regeneration in urodeles.

  12. A Non-Destructive Method for Distinguishing Reindeer Antler (Rangifer tarandus) from Red Deer Antler (Cervus elaphus) Using X-Ray Micro-Tomography Coupled with SVM Classifiers

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    Lefebvre, Alexandre; Rochefort, Gael Y.; Santos, Frédéric; Le Denmat, Dominique; Salmon, Benjamin; Pétillon, Jean-Marc

    2016-01-01

    Over the last decade, biomedical 3D-imaging tools have gained widespread use in the analysis of prehistoric bone artefacts. While initial attempts to characterise the major categories used in osseous industry (i.e. bone, antler, and dentine/ivory) have been successful, the taxonomic determination of prehistoric artefacts remains to be investigated. The distinction between reindeer and red deer antler can be challenging, particularly in cases of anthropic and/or taphonomic modifications. In addition to the range of destructive physicochemical identification methods available (mass spectrometry, isotopic ratio, and DNA analysis), X-ray micro-tomography (micro-CT) provides convincing non-destructive 3D images and analyses. This paper presents the experimental protocol (sample scans, image processing, and statistical analysis) we have developed in order to identify modern and archaeological antler collections (from Isturitz, France). This original method is based on bone microstructure analysis combined with advanced statistical support vector machine (SVM) classifiers. A combination of six microarchitecture biomarkers (bone volume fraction, trabecular number, trabecular separation, trabecular thickness, trabecular bone pattern factor, and structure model index) were screened using micro-CT in order to characterise internal alveolar structure. Overall, reindeer alveoli presented a tighter mesh than red deer alveoli, and statistical analysis allowed us to distinguish archaeological antler by species with an accuracy of 96%, regardless of anatomical location on the antler. In conclusion, micro-CT combined with SVM classifiers proves to be a promising additional non-destructive method for antler identification, suitable for archaeological artefacts whose degree of human modification and cultural heritage or scientific value has previously made it impossible (tools, ornaments, etc.). PMID:26901355

  13. HPLC-MS/MS shotgun proteomic research of deer antlers with multiparallel protein extraction methods.

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    Gao, Liang; Tao, Dingyin; Shan, Yichu; Liang, Zhen; Zhang, Lihua; Huo, Yushu; Zhang, Yukui

    2010-12-15

    Deer antlers mature rapidly in 60 days, and subsequently shed in 5 days with rapid ossification. During this procedure, the function of deer antlers changes significantly. Therefore, the profiling of antler proteome is helpful to discover important growing and shedding regulation proteins, which might be of great significance for studying development and regeneration. In this study, a parallel protein extraction strategy was developed to extract proteins from antlers of red deer with five different lysis solutions, followed by shotgun proteomic analysis by microflow reversed-phase liquid chromatography/electrospray ionization/tandem mass spectrometry (μRPLC-ESI-MS/MS) with a 30 cm-long serially coupled microcolumn. Our experimental results showed that the identified proteins extracted by five kinds of lysis solution were complementary to each other. In total, 416 unique proteins were identified, with relative molecular masses from 2000 to 600,000, and isoelectric points from 3.84 to 11.57. All these results demonstrate that the combination of parallel protein extraction strategy and μRPLC-ESI-MS/MS analysis with serially coupled long microcolumns might be of great significance for comprehensive proteomic research of deer antler.

  14. Genotyping of velvet antlers for identification of country of origin using mitochondrial DNA and fluorescence melting curve analysis with locked nucleic acid probes.

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    Ahn, Jeong Jin; Kim, Youngjoo; Hong, Ji Young; Kim, Gi Won; Hwang, Seung Yong

    2016-07-01

    Velvet antlers are used medicinally in Asia and possess various therapeutic effects. Prices are set according to the country of origin, which is unidentifiable to the naked eye, and therefore counterfeiting is prevalent. Additionally, antlers of the Canadian elk, which can generate chronic wasting disease, are prevalently smuggled and distributed in the market. Thus, a method for identifying the country of origin of velvet antlers was developed, using polymorphisms in mitochondrial DNA, fluorescence melting curve analysis and analysis of locked nucleic acids (LNA). This combined method is capable of identifying five genotypes of velvet antlers in a single experiment using two probes. It also has advantages in multiplexing, simplicity and efficiency in genotyping, when compared to real-time PCR or microarrays. The developed method can be used to improve identification rates in the velvet antler market and, by extension, research based on polymorphisms in DNA sequences.

  15. Chondroitin sulphate extracted from antler cartilage using high hydrostatic pressure and enzymatic hydrolysis

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    Chong-Tai Kim

    2014-12-01

    Full Text Available Chondroitin sulphate (CS, a major glycosaminoglycan, is an essential component of the extracellular matrix in cartilaginous tissues. Wapiti velvet antlers are a rich source of these molecules. The purpose of the present study was to develop an effective isolation procedure of CS from fresh velvet antlers using a combination of high hydrostatic pressure (100 MPa and enzymatic hydrolysis (papain. High CS extractability (95.1 ± 2.5% of total uronic acid was obtained following incubation (4 h at 50 °C with papain at pH 6.0 in 100 MPa compared to low extractability (19 ± 1.1% in ambient pressure (0.1 MPa. Antler CS fractions were isolated by Sephacryl S-300 chromatography and identified by western blot using an anti-CS monoclonal antibody. The antler CS fraction did not aggregate with hyaluronic acid in CL-2B chromatography and possessed DPPH radical scavenging activity at 78.3 ± 1.5%. The results indicated that high hydrostatic pressure and enzymatic hydrolysis procedure may be a useful tool for the isolation of CS from antler cartilaginous tissues.

  16. Unilateral antler combs from Romuliana

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    Petković Sofija

    2006-01-01

    Full Text Available In the course of investigations at Romuliana nine antler three-partite combs with a single row of teeth were found in the Late Roman horizons dating from the late 4th - mid 5th century. They were found in Tower 19, in the Palace II sector and in the Thermae sector. The combs can be classified as two types: three-partite unilateral combs with semicircular handle (Petković comb type VII and three-partite unilateral combs with triangular handle decorated with horse protomes (Petković comb type VI. Two groups of these finds were distinguished after more detailed analysis; the earlier one including specimens originating from the Chernyahov-Sîntana de Mureº culture and later one including specimens made under "barbarian"influence and produced in Romuliana. These finds confirm the continuity of settlement at Romuliana in the Late Roman period, from the final quarter of the 4th until the end of the 5th century and open up the question of the character of the settlement.

  17. Antler possession by west Greenland female caribou in relation to population characteristics

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    Henning Thing

    1986-06-01

    Full Text Available The frequency of antlerless adult female caribou (Rangifer tarandus groenlandicus was studied in four separate populations in west Greenland. Between the herds antlerlessness varied from 21% to 79%. An inverse relationship between winter range quality and percentage of unantlered cows is demonstrated. Relationship between calf percentage and maternal antler status was studied in one population and antlerless cows showed higher reproductive rate than antlered ones. In another population antlerless cows were almost absent outside the calving area. Calves of antlerless mothers were more susceptible to diseases and had significantly higher summer mortality than other calves, 42% and 27% respectively. The relative importance of factors influencing antler development under various environmental conditons are assessed and a close relationship between antlerlessness, physical condition, lactation, and length of period between calving and midsummer is discussed.

  18. A review of factors affecting antler composition and mechanics.

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    Landete-Castillejos, Tomas; Estevez, Jose A; Ceacero, Francisco; Garcia, Andres J; Gallego, Laureano

    2012-06-01

    Antlers constitute the only mammal model for limb regeneration. A number of factors affect antler regeneration. In this review, we examine such factors and the potential consequences for organ regeneration. As body mineral stores are depleted to grow antlers, physiological exhaustion is shown in the mineral composition, mechanical performance and, according to preliminary studies, porosity of the antler bone material. Nutrition plays an important role in antler characteristics. Thus, antler composition can be used as a diagnostic tool to assess mineral deficiencies in deer. Studies on ecological effects of exceptional weather in plants suggest that minor minerals, particularly Mn, may play disproportionately roles in mechanical performance of bone material. This suggests that Mn (and perhaps other minerals) is essential to incorporate Ca and P from resorbed skeleton material in antlers. Apart from implications for game management, some effects may have applications for medicine.

  19. Antlers honestly advertise sperm production and quality.

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    Malo, Aurelio F; Roldan, Eduardo R S; Garde, Julian; Soler, Ana J; Gomendio, Montserrat

    2005-01-22

    Evolutionary theory proposes that exaggerated male traits have evolved via sexual selection, either through female mate choice or male-male competition. While female preferences for ornamented males have been amply demonstrated in other taxa, among mammals sexual characters are commonly regarded as weapons whose main function is to enhance male competitiveness in agonistic encounters. One particularly controversial hypothesis to explain the function of male sexual characters proposes that they advertise male fertility. We test this hypothesis in red deer (Cervus elaphus), a species where sexual characters (antlers) reach an extreme degree of elaboration. We find that a global measure of relative antler size and complexity is associated with relative testes size and sperm velocity. Our results exclude the possibility that condition dependence, age or time of culling, drive these associations. Red deer antlers could signal male fertility to females, the ability to avoid sperm depletion throughout the reproductive season and/or the competitive ability of ejaculates. By contrast, male antlers could also signal to other males not only their competitive ability at the behavioural level (fighting ability) but also at the physiological level (sperm competition).

  20. Morphological observation of antler regeneration in red deer (Cervus elaphus).

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    Li, Chunyi; Suttie, James M; Clark, Dawn E

    2004-12-01

    Deer antler offers a unique opportunity to explore how nature solves the problem of mammalian appendage regeneration. Annual antler renewal is an example of epimorphic regeneration, which is known to take place through initial blastema formation. Detailed examination of the early process of antler regeneration, however, has thus far been lacking. Therefore, we conducted morphological observations on antler regeneration from naturally cast and artificially created pedicle/antler stumps. On the naturally cast pedicle stumps, early antler regeneration underwent four distinguishable stages (with the Chinese equivalent names): casting of previous hard antlers (oil lamp bowl), early wound healing (tiger eye), late wound healing and early regeneration (millstone), and formation of main beam and brown tine (small saddle). Overall, no cone-shaped regenerate, a common feature to blastema-based regeneration, was observed. Taken together with the examination on the sagittal plane of each regenerating stage sample, we found that there are considerable overlaps between late-stage wound healing and the establishment of posterior and anterior growth centers. Observation of antler regeneration from the artificially created stumps showed that the regeneration potential of antler remnants was significantly reduced compared with that of pedicle tissue. Interestingly, the distal portion of a pedicle stump had greater regeneration potential than the proximal region, although this differential potential may not be constitutive, but rather caused by whether or not pedicle antlerogenic tissue becomes closely associated with the enveloping skin at the cut plane. Antler formation could take place from the distal peripheral tissues of an antler/pedicle stump, without the obvious participation of the entire central bony portion. Overall, our morphological results do not support the notion that antler regeneration takes place through the initial formation of a blastema; rather, it may be a stem

  1. Histological examination of antler regeneration in red deer (Cervus elaphus).

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    Li, Chunyi; Suttie, James M; Clark, Dawn E

    2005-02-01

    Annual antler renewal presents the only case of epimorphic regeneration (de novo formation of a lost appendage distal to the level of amputation) in mammals. Epimorphic regeneration is also referred to as a blastema-based process, as blastema formation at an initial stage is the prerequisite for this type of regeneration. Therefore, antler regeneration has been claimed to take place through initial blastema formation. However, this claim has never been confirmed experimentally. The present study set out to describe systematically the progression of antler regeneration in order to make a direct histological comparison with blastema formation. The results showed that wound healing over a pedicle stump was achieved by ingrowth of full-thickness pedicle skin and resulted in formation of a scar. The growth centers for the antler main beam and brow tine were formed independently at the posterior and anterior corners of the pedicle stump, respectively. The hyperplastic perichondrium surmounting each growth center was directly formed in situ by a single type of tissue: the thickening distal pedicle periosteum, which is the derivative of initial antlerogenic periosteum. Therefore, the cells residing in the pedicle periosteum can be called antler stem cells. Antler stem cells formed each growth center by initially forming bone through intramembranous ossification, then osseocartilage through transitional ossification, and finally cartilage through endochondral ossification. There was an overlap between the establishment of antler growth centers and the completion of wound healing over the pedicle stump. Overall, our results demonstrate that antler regeneration is achieved through general wound healing- and stem cell-based process, rather than through initial blastema formation. Pedicle periosteal cells directly give rise to antlers. Histogenesis of antler regeneration may recapitulate the process of initial antler generation.

  2. Deer antler regeneration: a stem cell-based epimorphic process.

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    Li, Chunyi

    2012-03-01

    Full regeneration of deer antlers, a bona fide epimorphic process in mammals, is in defiance of the general rule of nature. Revealing the mechanism underlying this unique exception would place us in a better position to promote organ regeneration in humans. Antler regeneration takes place in yearly cycles from its pedicle, a permanent protuberance on the frontal bone. Both growing antlers and pedicles consist of internal (cartilage and bone) and external components (skin, blood vessels, and nerves). Recent studies have demonstrated that the regeneration of both internal and external components relies on the presence of pedicle periosteum (PP). PP cells express key embryonic stem cell markers (Oct4, Nanog, and SOX2) and are multipotent, so are termed antler stem cells. Now it is clear that proliferation and differentiation of PP cells directly forms internal antler components; however, how PP initiates and maintains the regeneration of external antler components is thus far not known. Based on the direct as well as indirect evidence that is presented in this review, I put forward the following hypothesis to address this issue. The full regenerative ability of external antler tissue components is achieved through PP-derived chemical induction and PP-derived mechanical stimulation: the former triggers the regeneration of these external components, whereas the latter drives their rapid elongation. Eventual identification of the putative PP-derived chemical factors would open up a new avenue for devising effective therapies for lesions involving each of these tissue components, be they traumatic, degenerative, or linked to developmental (genetic) anomalies.

  3. The ectopically antler growth of sika deer%梅花鹿鹿茸异位生长研究

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    高志光; 杨福合; 邢秀梅; 高颂; 赵桂炎

    2012-01-01

    In order to reveal the mechanism of antler development and elucidate the function of antlerogenic periosteum in the process,in we selected four one-year-old male sika deers.a full one side antlerogenic periosteum was removed to the frontal bone by surgery operation.The results showed that there was no antler grows in the place where the periosteum was removed,but the antler grows well in the frontal bone where the periosteum was received.The results in this experiment indicated that antlerogenic periosteum is the histological bases for antler formation.It will be help for increasing the antler production by ectopically antler method.%为了揭示鹿茸发生机理,阐明生茸区骨膜在鹿茸发生中的作用,选择4只1周岁雄性梅花鹿,在鹿茸发生前,通过外科手术将一侧完整的生茸区骨膜摘除并移植到额骨上。结果,摘除骨膜的生茸区没有发生鹿茸,而在被移植的额骨部位上发生了鹿茸且生长发育正常。证明了生茸区骨膜是鹿茸发生的组织基础,同时为通过异位生茸提高鹿茸产量开辟了新的途径。

  4. Biological effect of velvet antler polypeptides on neural stem cells from embryonic rat brain

    Institute of Scientific and Technical Information of China (English)

    LU Lai-jin; CHEN Lei; MENG Xiao-ting; YANG Fan; ZHANG Zhi-xin; CHEN Dong

    2005-01-01

    Background Velvet antler polypeptides (VAPs), which are derived from the antler velvets, have been reported to maintain survival and promote growth and differentiation of neural cells and, especially the development of neural tissues. This study was designed to explore the influence of VAPs on neural stem cells in vitro derived from embryonic rat brain. Methods Neural stem cells derived from E12-14 rat brain were isolated, cultured, and expanded for 7 days until neural stem cell aggregations and neurospheres were generated. The neurospheres were cultured under the condition of different concentration of VAPs followed by immunocytochemistry to detect the differentiation of neural stem cells. Results VAPs could remarkablely promote differentiation of neural stem cells and most neural stem cells were induced to differentiate towards the direction of neurons under certain concentration of VAPs.Conclusion Neural stem cells can be successfully induced into neurons by VAPs in vitro, which could provide a basis for regeneration of the nervous system.

  5. INTEGRATION IN ANTLER REINDEER BREEDING OF THE ALTAI REPUBLIC

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    Glotko A. V.

    2014-12-01

    Full Text Available In this article the questions of vertical integration which is necessary to bring the company of antler reindeer breeding out of crisis are considered. We have presented a scheme of participant of "supplier – consumer” integral interaction

  6. Digital data sets that describe aquifer characteristics of the Antlers aquifer in southeastern Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of constant recharge values for the Antlers aquifer in southeastern Oklahoma. The Early Cretaceous-age Antlers Sandstone...

  7. Digital data sets that describe aquifer characteristics of the Antlers aquifer in southeastern Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized aquifer boundaries of the Antlers aquifer in southeastern Oklahoma. The Early Cretaceous-age Antlers Sandstone is an important...

  8. Digital data sets that describe aquifer characteristics of the Antlers aquifer in southeastern Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized water-level elevation contours for the Antlers aquifer in southeastern Oklahoma. The Early Cretaceous-age Antlers Sandstone is an...

  9. Identification of key tissue type for antler regeneration through pedicle periosteum deletion.

    Science.gov (United States)

    Li, Chunyi; Mackintosh, Colin G; Martin, Shirley K; Clark, Dawn E

    2007-04-01

    Epimorphic regeneration is the "holy grail" of regenerative medicine. Research aimed at investigating the various models of epimorphic regeneration is essential if a fundamental understanding of the factors underpinning this process are to be established. Deer antlers are the only mammalian appendages that are subject to an annual cycle of epimorphic regeneration. In our previous studies, we have reported that histogenesis of antler regeneration relies on cells resident within the pedicle periosteum (PP). The present study elaborates this finding by means of functional studies involving the deletion of PP. Four yearling and four 2-year-old stags were selected for total PP deletion or partial PP deletion experiments. Of the animals in the total PP deletion group, one showed no signs of antler regeneration throughout the antler growth season. Two showed substantial and one showed marginal delays in antler regeneration (at 34, 20 and 7 days, respectively) compared with the corresponding sham-operated sides. Histological investigation revealed that the delayed antlers were derived from regenerated PP. Unexpectedly, the regenerative capacity of the antler from the total periosteum-deleted pedicles depended on antler length at surgery. Of the four deer that had partial PP deletion, two regenerated antlers exclusively from the left-over PP on the pedicle shafts in the absence of participation from the pedicle bone proper. The combined results from the PP deletion experiments convincingly demonstrate that the cells of the PP are responsible for antler regeneration.

  10. [Preparation and Determination of Insulin-like Growth Factor I in Deer Antler, Heart and Blood].

    Science.gov (United States)

    Chen, Fan-bo; Yin, Jian-yuan; Liu, Jing-yan; Yang, Yu-xia; Sun, Dan-dan; Liu, Ji-hua

    2014-12-01

    To optimize the method for preparation of the insulin-like growth factor I (IGF-I ) in deer antler, and to determine the IGF-I in deer antler, heart and blood. Ultrasonic extraction was used to extract IGF-I from different tissues of deer with ammonia-ammonium acetate buffer, followed by ultrafiltration and solid phase extraction to concentrate and purify the samples. At the same time, ethanol precipitation method was carried out in the purification of IGF-I ultrafiltratein deer antler, a parallel test proceeded and radio immune assay (RIA) was set to determine the IGF-I in deer antler, heart and blood. The IGF-I (60.8 ng/g) in deer antler by solid phase extraction was only existed in 30% methanol aqueous solution which was much higher than that (46.1 ng/g) by ethanol precipitation method. The quantities of IGF-I in deer antler, heart and blood were significantly different, it was 61.9 ng/g in antler and 21.9 ng/mL in blood, while there was no IGF-I tested in deer heart. Solid phase extraction is superior to ethanol precipitation method in preparing IGF-I in deer antler and it is clear that the IGF-I contained in deer antler is significantly higher than that in deer heart and blood, so it is the best choice to take IGF-I from deer antler.

  11. Getting the timing right: antler growth phenology and sexual selection in a wild red deer population.

    Science.gov (United States)

    Clements, Michelle N; Clutton-Brock, Tim H; Albon, Steve D; Pemberton, Josephine M; Kruuk, Loeske E B

    2010-10-01

    There has been growing interest in the determinants of the annual timing of biological phenomena, or phenology, in wild populations, but research on vertebrate taxa has primarily focused on the phenology of reproduction. We present here analyses of the phenology of the annual growth of a secondary sexual characteristic, antlers in red deer (Cervus elaphus) males. The long-term individual-based data from a wild population of red deer on the Isle of Rum, Scotland allow us to consider ecological factors influencing variation in the phenology of growth of antlers, and the implications of variation in antler growth phenology with respect to the phenotype of antler grown (antler mass) and annual breeding success. The phenology of antler growth was influenced by local environmental conditions: higher population density delayed both the start date (during spring) and the relative end date (in late summer) of antler growth, and warmer temperatures in the September and April prior to growth advanced start and end dates, respectively. Furthermore, there was variation between individuals in this phenotypic plasticity of start date, although not in that of end date of growth. The phenology of antler growth impacted on the morphology of antlers grown, with individuals who started and ended growth earliest having the heaviest antlers. The timing of antler growth phenology was associated with breeding success in the following mating season, independently of the mass of antlers grown: an earlier start of antler growth was associated with siring a higher number of the calves born the following spring. Our results suggest that the phenology of traits that are not directly correlated with offspring survival may also regularly show correlations with fitness.

  12. Potential of the Bucharest 3 MV Tandetron™ for IBA studies of deer antler mineralization

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, S. [Departamento Anatomía Patológica, University of Cadiz (Spain); Garcia, A.; Landete-Castillejos, T.; Gallego, L. [IREC, Sección Albacete (CSIC-UCLM-JCCM), University of Castilla-La Mancha, Albacete (Spain); Pantelica, D.; Pantelica, Ana [Horia Hulubei National Institute for Physics and Nuclear Engineering, Bucharest-Magurele (Romania); Preoteasa, E.A., E-mail: eugenpreoteasa@gmail.com [Horia Hulubei National Institute for Physics and Nuclear Engineering, Bucharest-Magurele (Romania); Scafes, Adela; Straticiuc, M. [Horia Hulubei National Institute for Physics and Nuclear Engineering, Bucharest-Magurele (Romania)

    2016-03-15

    Combined PIXE and PIGE analysis was applied at the new Bucharest Tandetron to investigate biomineralization in two calcified tissues, deer antlers and femur bone. By annual loss and fast re-growth, antlers are a valuable model for bone as a dynamical system. Samples characterized by optical microscopy and histology were analyzed for P, Ca, F, Na, Mg, S, Cl, K, Zn, Sr by 3 MeV proton simultaneous PIXE and PIGE, using a hydroxyapatite standard and other reference materials. Good correlation between methods was found for P, and the concentrations were related to biological data. Antlers showed lower mineralization than femur, with the lowest values in the third antler beam. A power function of mineralization vs. “mineral age” of antlers was found. Thus combined PIXE and PIGE of antlers may bring highly relevant insights in biomineralization research.

  13. Potential of the Bucharest 3 MV Tandetron™ for IBA studies of deer antler mineralization

    Science.gov (United States)

    Gomez, S.; Garcia, A.; Landete-Castillejos, T.; Gallego, L.; Pantelica, D.; Pantelica, Ana; Preoteasa, E. A.; Scafes, Adela; Straticiuc, M.

    2016-03-01

    Combined PIXE and PIGE analysis was applied at the new Bucharest Tandetron to investigate biomineralization in two calcified tissues, deer antlers and femur bone. By annual loss and fast re-growth, antlers are a valuable model for bone as a dynamical system. Samples characterized by optical microscopy and histology were analyzed for P, Ca, F, Na, Mg, S, Cl, K, Zn, Sr by 3 MeV proton simultaneous PIXE and PIGE, using a hydroxyapatite standard and other reference materials. Good correlation between methods was found for P, and the concentrations were related to biological data. Antlers showed lower mineralization than femur, with the lowest values in the third antler beam. A power function of mineralization vs. "mineral age" of antlers was found. Thus combined PIXE and PIGE of antlers may bring highly relevant insights in biomineralization research.

  14. Inhibitory effects of deer antler aqua-acupuncture, the pilose antler of Cervus Korean TEMMINCK var mantchuricus Swinhoe, on type II collagen-induced arthritis in rats.

    Science.gov (United States)

    Kim, Yeon-Kye; Kim, Kyung-Sook; Chung, Kang-Hyun; Kim, Jin-Gyu; Kim, Kap-Sung; Lee, Young-Choon; Chang, Young-Chae; Kim, Cheorl-Ho

    2003-07-01

    Water extract of deer antler aqua-acupunture (DAA) prepared from the growing antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe, was used to investigate the efficacy of a traditional immunosuppressive and immuno-activating Korean aqua-acupuncture, on the development of type II collagen (CII)-induced arthritis (CIA) in rats. The onset of arthritis was observed at the 24th day after the CII-immunization in rats, and the severity of CIA was gradually developed. As compared with rats treated with saline, DAA i.p. injected at doses of more than 50 microg/kg once a day for 14 days inhibited the ability of inguinal lymph node cells to produce T cell cytokines interleukin 2 and interferon-gamma when the cells were obtained from rats 24 days after immunization and cultured in vitro with CII. Treatment with DAA also inhibited the production of macrophage cytokines interleukin-1beta, IL-6 and tumor necrosis factor alpha in response to in vitro stimulation of lymph node and macrophage cells with CII. In addition, in order to evaluate the influence of DAA on the incidence and development of arthritis in rat CIA, rats were immunized twice at a 3-week interval with bovine CII, with DAA being given i.p. once a day for 14 days with four different regimens. A 14-day course of DAA treatment at a daily dose of 100 microg/kg, which began on the day of the first CII immunization, suppressed the development of arthritis, as well as antibody formation and delayed-type hypersensitivity to CII. Treatment with DAA, which started on the same day as the booster immunization, also resulted in inhibition of development of arthritis and of immune responses to CII. However, treatment with DAA, which was prophylactically started prior to a primary immunization, did not inhibit the development of arthritis and immune response to CII. Furthermore, DAA extract did not affect the established diseases.

  15. Effect of testosterone on antler growth in yearling male reindeer

    Directory of Open Access Journals (Sweden)

    Morten Ryg

    1983-05-01

    Full Text Available 1. The effect of exogenous testosterone on ander growth in yearling male reindeer (Rangifer tarandus tarandus was tested. 2. Testosterone (33 mg/kg inhibited antler growth, and in one animal induced cleaning and subsequent casting of the antlers. This animal grew a new set of antlers, which were cleaned at the normal time. 3. During treatment, there was an inverse relationship between peak testosterone levels and antler growth rate. 4. There was no effect of treatment on body weight or food intake. 5. It is concluded that the effects of testosterone on antler growth are qualitatively the same in reindeer as in other deer. However, because high testosterone doses were necessary to produce effects, it is questionable whether this hormone normally is responsible for the cessation of antler growth in reindeer.Virkningen av testosteron på gevirvekst hos ettårige reinbukker.Abstract in Norwegian / Sammendrag: 1. Virkningen av testosteron på gevirvekst hos ett-årige reinbukker (Rangifer tarandus tarandus ble undersøkt. 2. Testosteron (33 mg/kg hemmet gevirveksten, og hos ett dyr førte behandlingen til at geviret ble feiet og deretter felt. Deretter vokste det ut ett nytt gevir, som ble feiet til vanlig tid. 3. Det var en negativ korrelasjon mellom maksimale testosteronnivåer og gevirvekst under behandlingen. 4. Det var ingen effekt på forinntak eller vektutvikling. 5. Det blir konkludert med at virkningen av testosteron på gevirvekst er kvalitativt den samme hos rein som hos andre hjortedyr. Det er likevel tvilsomt om testosteron normalt er ansvarlig for avslutningen av gevirvekst hos rein, fordi store testosterondoser måtte til for å få noen virkning.Testosteronin vaikutus vuodenikåisten urosporojen sarvien kasvuun.Abstract in Finnish / Tiivistelmä: 1. Tutkimuksessa seurattiin ruiskeena annetun testosteronin vaikutusta vuodenikåisten urosporojen (Rangifer tarandus tarandus sarvien kasvuun. 2. Testosteron! (33 mg/kg hidasti sarvien

  16. Variations of selected trace element contents in two layers of red deer antlers

    Directory of Open Access Journals (Sweden)

    Giżejewska Aleksandra

    2016-12-01

    Full Text Available Introduction: Hard antlers of deer are unique bioindicators of environmental metal pollutions, but sampling methods presented in the literature are inconsistent. Due to the specific growth pattern of antlers and their histological structure, sampling methods described in the literature were reviewed, the suitability of using mixed samples of both antler layers as element bioindicators was assessed, and the codified method of antler sampling used for bioindication was described. Material and Methods: Lead, cadmium, mercury, arsenic, copper, zinc, and iron in trabecular and cortical parts of hard antlers of red deer (Cervus elaphus were determined using different methods of atomic absorption spectrometry (depending on the element. Results: Mean mercury content in trabecular bone (0.010 ±0.018 mg/kg was 5 times higher than in cortical bone (0.002 ±0.003 mg/kg. Mean iron concentration was approximately 15 times higher in trabecular (239.83 ±130.15 mg/kg than in cortical bone (16.17 ±16.44 mg/kg. Concentrations of other analysed elements did not differ statistically between antler layers. Conclusion: In mixed antler samples, concentrations of mercury and iron depend on the particular antler layer contents. This therefore warrants caution when comparing results across studies and specification of the sampling methodology of antlers is highly recommended.

  17. Preferences of Rusa timorensis to Grasses and Their Body Morphometry and Velvet Antler Characteristics

    Directory of Open Access Journals (Sweden)

    M. Sudibyo

    2013-08-01

    Full Text Available Timor deer (Rusa timorensis is a wild native animal to Indonesia. The stags produce a high economic value of velvet antler (VA. This study was designed to evaluate the feed preference, nutrient consumption, age and morphometric of deer in relation to their velvet antler product (weigth and length and quality (mineral and amino acids. Five stags with three ages classes were offered 3 combinations of 4 grasses in a captive area. Grasses were offered for 3 periods of 12 consecutive days during velvet antler growth period. Velvet antlers were harvested at 36 days old and analysed for their chemical content. The result showed that Timor deer had different preference to the grasses offered. Deer had a high preference on the combination of Pennisetum purpureum, Commelina benghalensis, Hierochloe horsfieldii, and Sorghum caudatum. High intake of grasses increased body weight. The regresion equation between the weight or length of velvet antler withage (year and girth size (cm were: Y (velvet antler weight= 0.43 + 0.03 (age, r2= 0.99, P<0.05, and Y (length of velvet antler = 5.7 + 0.31 (girth size, r2= 0.99, P<0.05. Aspartic acid, glutamic acid, and proline content of velvel antler were high in the older deer. The older deer having high girth size had the higher quality of velvet antler.

  18. Gene expression of axon growth promoting factors in the deer antler.

    Directory of Open Access Journals (Sweden)

    Wolfgang Pita-Thomas

    Full Text Available The annual regeneration cycle of deer (Cervidae, Artiodactyla antlers represents a unique model of epimorphic regeneration and rapid growth in adult mammals. Regenerating antlers are innervated by trigeminal sensory axons growing through the velvet, the modified form of skin that envelopes the antler, at elongation velocities that reach one centimetre per day in the common deer (Cervus elaphus. Several axon growth promoters like NT-3, NGF or IGF-1 have been described in the antler. To increase the knowledge on the axon growth environment, we have combined different gene-expression techniques to identify and characterize the expression of promoting molecules not previously described in the antler velvet. Cross-species microarray analyses of deer samples on human arrays allowed us to build up a list of 90 extracellular or membrane molecules involved in axon growth that were potentially being expressed in the antler. Fifteen of these genes were analysed using PCR and sequencing techniques to confirm their expression in the velvet and to compare it with the expression in other antler and skin samples. Expression of 8 axon growth promoters was confirmed in the velvet, 5 of them not previously described in the antler. In conclusion, our work shows that antler velvet provides growing axons with a variety of promoters of axon growth, sharing many of them with deer's normal and pedicle skin.

  19. [Simultaneous determination of eleven sex hormones in antler velvet health products by gas chromatography-tandem mass spectrometry].

    Science.gov (United States)

    Lu, Chunmei; Wang, Mingtai; Mu, Jun; Lu, Lijun; Zhou, Xiao

    2011-06-01

    A method for the simultaneous determination of 11 sex hormones in antler velvet health products by gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed. The sex hormones in antler velvet were enriched and purified by solid phase extraction and derivatized with heptafluorobutyric acid anhydride (HFBA). A DB-5 column (30 m x 0.25 mm, 0.25 microm) with nonlinear gradient program was used in GC separation. The sex hormones were determined in the multiple reaction monitoring mode. The method realized the complete separation of 11 sex hormones. The limits of detection of this method were from 1.0 to 5.0 microg/kg for the 11 sex hormones. The correlation coefficients were between 0.991 6 and 0.999 9. The recoveries were in the range of 67.4% - 99.1% with relative standard deviations (RSDs) of 2.6% - 13%. This method is accurate and reliable for the determination of the sex hormones in antler velvet health products.

  20. Study on the Changes in Enzyme and Insulin-like Growth Factor-1 Concentrations in Blood Serum and Growth Characteristics of Velvet Antler during the Antler Growth Period in Sika Deer (

    Directory of Open Access Journals (Sweden)

    Jaehyun Park

    2015-09-01

    Full Text Available This study was conducted to investigate changes in blood enzyme parameters and to evaluate the relationship between insulin-like growth factor-1 (IGF-1, antler growth and body weight during the antler growth of sika deer (Cervus nippon. Serum enzyme activity and IGF-1 concentrations were measured in blood samples collected from the jugular and femoral veins at regular intervals during the antler growth period. Blood samples were taken in the morning from fasted stags (n = 12 which were healthy and showed no clinical signs of disease. Alfalfa was available ad libitum and concentrates were given at 1% of body weight to all stags. The experimental diet was provided at 9 am with water available at all times. There were no significant differences in alkaline phosphatase, aspartate aminotransferase, and alanine aminotransferase during antler growth, but alkaline phosphatase concentrations increased with antler growth progression, and the highest alkaline phosphatase concentration was obtained 55 days after antler casting. Serum IGF-1 concentrations measured from blood samples taken from the jugular vein during antler growth, determined that levels of IGF-1 was associated with body weight and antler growth patterns. Serum IGF-1 concentrations were higher at the antler cutting date than other sampling dates. Antler length increased significantly during antler growth (p<0.001, and there was a similar trend to between right and left beams. Body weight increased with antler growth but was not significant. Consequently it appeared that serum alkaline phosphatase concentration was related to antler growth and both antler growth and body weight were associated positively with IGF-1 concentrations during antler growth.

  1. A PCR-based assay for discriminating Cervus and Rangifer (Cervidae) antlers with mitochondrial DNA polymorphisms.

    Science.gov (United States)

    Kim, Young Hwa; Kim, Eung Soo; Ko, Byong Seob; Oh, Seung-Eun; Ryuk, Jin-Ah; Chae, Seong Wook; Lee, Hye Won; Choi, Go Ya; Seo, Doo Won; Lee, Mi Young

    2012-07-01

    This study describes a method for discriminating Rangifer antlers from true Cervus antlers using agarose gel electrophoresis, capillary electrophoresis, quantitative real-time PCR, and allelic discrimination. Specific primers labeled with fluorescent tags were designed to amplify fragments from the mitochondrial D-loop genes for various Cervus subspecies and Rangifer tarandus differentially. A 466-bp fragment that was observed for both Cervus and Rangifer antlers served as a positive control, while a 270-bp fragment was specifically amplified only from Rangifer antlers. Allelic discrimination was used to differentiate between Cervus and Rangifer antlers, based on the amplification of specific alleles for both types of antlers. These PCR-based assays can be used for forensic and quantitative analyses of Cervus and Rangifer antlers in a single step, without having to obtain any sequence information. In addition, multiple PCR-based assays are more accurate and reproducible than a single assay for species-specific analysis and are especially useful in this study for the identification of original Cervus deer products from fraudulent Rangifer antlers.

  2. Antler regrowth as a form of epimorphic regeneration in vertebrates - a comparative view.

    Science.gov (United States)

    Kierdorf, Uwe; Kierdorf, Horst

    2012-01-01

    The annual regrowth of deer antlers is a unique case of extensive appendage regeneration in mammals. This review compares basic aspects of antler regeneration with epimorphic regeneration in other vertebrate taxa. The mesenchymal cells that build up the regenerating antler are not derived from dedifferentiated cells in the pedicle stump, but from the proliferation of cells of the pedicle periosteum; and based on different lines of evidence it has more recently been suggested that the pedicle periosteum contains stem cells that are periodically activated to produce a new antler. This constitutes a difference to urodele limb regeneration, where the blastema is (largely) formed from dedifferentiated cells. Antler regeneration involves healing of the large casting wound with no or only minor scarring, making the antler an interesting model for the control of scarring in mammals. Contrary to urodele limb regeneration, antler regrowth does not depend on a functional nerve supply. In our view, a comparative analysis of different regeneration phenomena, including antler regeneration, probably offers the best chance for achieving significant progress in regenerative medicine.

  3. Antler stiffness in moose (Alces alces): correlated evolution of bone function and material properties?

    Science.gov (United States)

    Blob, Richard W; Snelgrove, Jason M

    2006-09-01

    The material properties of bone can vary considerably among skeletal elements from different parts of the body that serve different functions. However, functional demands placed on a specific type of skeletal element also can vary at a variety of scales, such as between different parts of the element, among individuals of a species, and across species. Variation in bone material properties might be correlated with differing functional demands at any of these scales. In this study we performed three-point bending tests on bone specimens extracted from antlers of moose (Alces alces) to test for three types of variation in bone material stiffness (Young's modulus): within the antler structure, between populations of moose, and between moose and other deer species. Because superficial portions of the antler are exposed to greater bending stress and strain than deeper portions, and because the antler beam (the basal shaft that attaches to the skull) is subjected to greater bending moments than more distal parts of the antler, we predicted that superficial bone and bone from the beam would be stiffer than bone from other parts of the antler. Instead, we identified no significant differences in these comparisons. There were also no significant differences in antler stiffness between moose from Michigan and the Yukon, even though the rapid growth required of antlers from northern latitudes like the Yukon has the potential to compromise bone material properties. However, moose have significantly stiffer antlers (11.6 +/- 0.45 GPa, mean +/- SE) than any other deer in the odocoileine lineage. Moreover, phylogenetic reconstructions of the evolution of antler stiffness in deer indicate a strong potential that high antler stiffness is a derived feature of moose. The unusual palmate shape of moose antlers likely subjects their antler beams to higher bending moments than found in other odocoileines, a factor that may have contributed to the evolutionary divergence of moose antler

  4. Deer antler--a novel model for studying organ regeneration in mammals.

    Science.gov (United States)

    Li, Chunyi; Zhao, Haiping; Liu, Zhen; McMahon, Chris

    2014-11-01

    Deer antler is the only mammalian organ that can fully grow back once lost from its pedicle - the base from which it grows. Therefore, antlers probably offer the most pertinent model for studying organ regeneration in mammals. This paper reviews our current understanding of the mechanisms underlying regeneration of antlers, and provides insights into the possible use for human regenerative medicine. Based on the definition, antler renewal belongs to a special type of regeneration termed epimorphic. However, histological examination failed to detect dedifferentiation of any cell type on the pedicle stump and the formation of a blastema, which are hallmark features of classic epimorphic regeneration. Instead, antler regeneration is achieved through the recruitment, proliferation and differentiation of the single cell type in the pedicle periosteum (PP). The PP cells are the direct derivatives of cells resident in the antlerogenic periosteum (AP), a tissue that exists in prepubertal deer calves and can induce ectopic antler formation when transplanted elsewhere on the deer body. Both the AP and PP cells express key embryonic stem cell markers and can be induced to differentiate into multiple cell lineages in vitro and, therefore, they are termed antler stem cells, and antler regeneration is a stem cell-based epimorphic regeneration. Comparisons between the healing process on the stumps from an amputated mouse limb and early regeneration of antlers suggest that the stump of a mouse limb cannot regenerate because of the limited potential of periosteal cells in long bones to proliferate. If we can impart a greater potential of these periosteal cells to proliferate, we might at least be able to partially regenerate limbs lost from humans. Taken together, a greater understanding of the mechanisms that regulate the regeneration of antlers may provide a valuable insight to aid the field of regenerative medicine. This article is part of a Directed Issue entitled: Regenerative

  5. Nerve Growth Factor mRNA Expression in the Regenerating Antler Tip of Red Deer (Cervus elaphus)

    Science.gov (United States)

    Li, Chunyi; Stanton, Jo-Ann L.; Robertson, Tracy M.; Suttie, James M.; Sheard, Philip W.; John Harris, A.; Clark, Dawn E.

    2007-01-01

    Deer antlers are the only mammalian organs that can fully regenerate each year. During their growth phase, antlers of red deer extend at a rate of approximately 10 mm/day, a growth rate matched by the antler nerves. It was demonstrated in a previous study that extracts from deer velvet antler can promote neurite outgrowth from neural explants, suggesting a possible role for Nerve Growth Factor (NGF) in antler innervation. Here we showed using the techniques of Northern blot analysis, denervation, immunohistochemistry and in situ hybridization that NGF mRNA was expressed in the regenerating antler, principally in the smooth muscle of the arteries and arterioles of the growing antler tip. Regenerating axons followed the route of the major blood vessels, located at the interface between the dermis and the reserve mesenchyme of the antler. Denervation experiments suggested a causal relationship exists between NGF mRNA expression in arterial smooth muscle and sensory axons in the antler tip. We hypothesize that NGF expressed in the smooth muscle of the arteries and arterioles promotes and maintains antler angiogenesis and this role positions NGF ahead of axons during antler growth. As a result, NGF can serve a second role, attracting sensory axons into the antler, and thus it can provide a guidance cue to define the nerve track. This would explain the phenomenon whereby re-innervation of the regenerating antler follows vascular ingrowth. The annual growth of deer antler presents a unique opportunity to better understand the factors involved in rapid nerve regeneration. PMID:17215957

  6. Digital data sets that describe aquifer characteristics of the Antlers aquifer in southeastern Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of a constant hydraulic conductivity value for the Antlers aquifer in southeastern Oklahoma. The Early Cretaceous-age...

  7. Anti-bone resorption activity of deer antler aqua-acupunture, the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe (Nokyong) in adjuvant-induced arthritic rats.

    Science.gov (United States)

    Kim, Kyung-Ho; Kim, Kap-Sung; Choi, Byeong-Joon; Chung, Kang-Hyun; Chang, Young-Chae; Lee, Seung-Duk; Park, Kwan-Kyu; Kim, Hyung-Min; Kim, Cheorl-Ho

    2005-01-15

    Effect of deer antler aqua-acupunture (DAA), prepared from the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe, a traditional immunosuppressive acupuncture, was evaluated to assess the reductions in bone mass, strength, and turnover in adjuvant-induced arthritic rats. For measuring the above parameters, a 20-day dosing experiment was performed using 6-week-old female Lewis rats. Arthritis was induced by injecting the adjuvant into the hind paw of the Lewis rats. The age-dependent increases in the body weight, lumbar bone mineral content and density (BMC and BMD) and compressive strength were disturbed in the arthritic rats. At 10 days, the histomorphometric parameters of bone formation (BFR/BS and BFR/BV) and the serum osteocalcin levels were significantly reduced compared with the baseline controls of Lewis rats. However, the BMC values corrected for body weight did not differ significantly between the arthritic and normal rats, and the bone minerals were not reduced when they were compared with the baseline controls. At 20 days, the parameters of bone minerals and strength of the lumbar body in the arthritic rats, both with and without correction for body weight, were significantly reduced compared with the baseline controls. The trabecular mineralizing surface remained significantly reduced and the osteoclast numbers were increased. DAA at the doses of 10, 20, 50 and 100 microg/kg, administered by Shinsu (B23) acupuncture daily from the start of the experiment, significantly prevented the development of the chronic paw edema at 20 days. The reductions in the parameters such as bone minerals, strength, and trabecular bone formation, and the increase in osteoclast number were alleviated by this DAA. Age-dependent increases in the lumbar height, disturbed by the adjuvant injection, were also maintained. These results indicated that a 20-day-period is necessary to obtain sufficient reductions in the bone mass and strength of the lumbar body

  8. Antler growth in male roe deer in field hunting grounds in Vojvodina: Effect of age on trophy value

    Directory of Open Access Journals (Sweden)

    Gačić Dragan

    2006-01-01

    Full Text Available Antler growth in male roe deer (Capreolus capreolus L was studied on the representative sample consisting of 546 trophies (227 from Bačka and 319 from Banat hunted in the period 19982005. No significant differences in antler characters and trophy values were noted between Bačka and Banat (except weight of antlers for 5 year old males, and the data for both regions were pooled. Antler growth is a curvilinear function of age. Mean values of length, weight and volume of antlers, and total trophy score varied significantly between the males in different age groups. The study results prove that in Vojvodina field hunting grounds, healthy males attain the culmination in antler growth and trophy value at the age of six years but already after the age of seven years, they show the first sign of old age and decline.

  9. Localization and characterization of STRO-1 cells in the deer pedicle and regenerating antler.

    Directory of Open Access Journals (Sweden)

    Hans J Rolf

    Full Text Available The annual regeneration of deer antlers is a unique developmental event in mammals, which as a rule possess only a very limited capacity to regenerate lost appendages. Studying antler regeneration can therefore provide a deeper insight into the mechanisms that prevent limb regeneration in humans and other mammals, and, with regard to medical treatments, may possibly even show ways how to overcome these limitations. Traditionally, antler regeneration has been characterized as a process involving the formation of a blastema from de-differentiated cells. More recently it has, however, been hypothesized that antler regeneration is a stem cell-based process. Thus far, direct evidence for the presence of stem cells in primary or regenerating antlers was lacking. Here we demonstrate the presence of cells positive for the mesenchymal stem cell marker STRO-1 in the chondrogenic growth zone and the perivascular tissue of the cartilaginous zone in primary and regenerating antlers as well as in the pedicle of fallow deer (Dama dama. In addition, cells positive for the stem cell/progenitor cell markers STRO-1, CD133 and CD271 (LNGFR were isolated from the growth zones of regenerating fallow deer antlers as well as the pedicle periosteum and cultivated for extended periods of time. We found evidence that STRO-1(+ cells isolated from the different locations are able to differentiate in vitro along the osteogenic and adipogenic lineages. Our results support the view that the annual process of antler regeneration might depend on the periodic activation of mesenchymal progenitor cells located in the pedicle periosteum. The findings of the present study indicate that not only limited tissue regeneration, but also extensive appendage regeneration in a postnatal mammal can occur as a stem cell-based process.

  10. Anti-resorptive effect of pilose antler blood (Cervus nippon Temminck) in ovariectomized rats.

    Science.gov (United States)

    Yang, Jian-Hong; Cao, Yi; Wang, Rui-Lin; Fei, Yu-Rong; Zhang, Hui; Feng, Pu; Liu, Jing

    2010-06-01

    Anti-bone resorption activity of pilose antler blood (Cervus nippon Temminck) were evaluated in ovariectomized Wistar rats. The rats were randomly divided into sham operated group (SHAM), ovariectomized group (OVX) and pilose antler blood treated group. The ovariectomized rats were treated with pilose antler blood orally in 4000 microl/kg daily doses for 10 weeks. Compared with SHAM group, serum 17 beta-estradiol level decreased significantly and osteocalcin level increased significantly in OVX group, indicating successful model of osteoporosis. The experiments showed that the bone mineral density of the lumbar spine and left femur in OVX group decreased remarkably compared to SHAM group but normalized by treatment with pilose antler blood. Additionally, serum levels of insulin-like growth factor-land testosterone were lower obviously in OVX group than those in SHAM group but preserved by pilose antler blood treatment. However, no obvious changes in serum levels of calcium, phosphorus, total alkaline phosphatase and osteoprotegerin were observed among three groups. These results suggested that administration of pilose antler blood was effective in alleviating osteoporosis in ovariectomized rats.

  11. Adult stem cells and mammalian epimorphic regeneration-insights from studying annual renewal of deer antlers.

    Science.gov (United States)

    Li, Chunyi; Yang, Fuhe; Sheppard, Allan

    2009-09-01

    Mammalian organ regeneration is the "Holy Grail" of modern regenerative biology and medicine. The most dramatic organ replacement is known as epimorphic regeneration. To date our knowledge of epimorphic regeneration has come from studies of amphibians. Notably, these animals have the ability to reprogram phenotypically committed cells at the amputation plane toward an embryonic-like cell phenotype (dedifferentiation). The capability of mammals to initiate analogous regeneration, and whether similar mechanisms would be involved if it were to occur, remain unclear. Deer antlers are the only mammalian appendages capable of full renewal, and therefore offer a unique opportunity to explore how nature has solved the problem of mammalian epimorphic regeneration. Following casting of old hard antlers, new antlers regenerate from permanent bony protuberances, known as pedicles. Studies through morphological and histological examinations, tissue deletion and transplantation, and cellular and molecular techniques have demonstrated that antler renewal is markedly different from that of amphibian limb regeneration (dedifferentiation-based), being a stem cell-based epimorphic process. Antler stem cells reside in the pedicle periosteum. We envisage that epimorphic regeneration of mammalian appendages, other than antler, could be made possible by recreating comparable milieu to that which supports the elaboration of that structure from the pedicle periosteum.

  12. Health benefits of deer and elk velvet antler supplements: a systematic review of randomised controlled studies.

    Science.gov (United States)

    Gilbey, Andrew; Perezgonzalez, Jose D

    2012-12-14

    The aim of this systematic review was to evaluate the evidence from RCTs of velvet antler supplements for any condition, using the QUOROM statement as a guiding framework. Four electronic databases (PubMed, Medline, Web of Science and Academic search premier, via the bibliographical platform, Endnote) and two review articles were searched for all randomised clinical trials of velvet antler supplements. Retrieved trials were evaluated according to standardised criteria. Seven RCTs were identified as satisfying all inclusion criteria and examined the effectiveness of velvet antler for rheumatoid arthritis (2), osteoarthritis (1), sexual function (1), and sporting performance enhancement (3). Their methodological quality ranged from 3-5, as measured on the Jadad scale. Two RCTs reported some positive effects of velvet antler supplements, but neither were convincing while the remaining five RCTs found no effect of velvet antler supplements. Claims made for velvet antler supplements do not appear to be based upon rigorous research from human trials, although for osteoarthritis the findings may have some promise.

  13. Spin effects in the antler event topology at hadron colliders

    CERN Document Server

    Edelhäuser, Lisa; Park, Myeonghun

    2012-01-01

    We investigate spin correlation effects in the "antler" event topology pp-> A-> B1, B2 -> l^{-}, C1, l^{+}, C2 at the LHC. We study the shapes of several kinematic variables, including the relative pseudorapidity, relative azimuthal angle and the energies of the two leptons, as well as several mass variables M_{ll}, Meff, \\sqrt{s}_{min}, MT2, MCT and MCTx. We focus on the two kinematic extremes of \\sqrt{s} - threshold and infinity - and derive analytical expressions for the differential distributions of several variables, most notably the cos{\\theta_{ll}}^* variable proposed by Barr in hep-ph/0511115. For all possible spin assignments of particles A, B and C, we derive the cos{\\theta_{ll}}^* differential distribution at threshold, including the effects of spin correlations. Our analytical results help identify the problematic cases for spin discrimination.

  14. European roe deer antlers as an environmental archive for fallout (236)U and (239)Pu.

    Science.gov (United States)

    Froehlich, M B; Steier, P; Wallner, G; Fifield, L K

    2016-01-01

    Anthropogenic (236)U and (239)Pu were measured in European roe deer antlers hunted between 1955 and 1977 which covers and extends beyond the period of intensive nuclear weapons testing (1954-1962). The antlers were hunting trophies, and hence the hunting area, the year of shooting and the approximate age of each animal is given. Uranium and plutonium are known to deposit in skeletal tissue. Since antler histology is similar to bone, both elements were expected in antlers. Furthermore, roe deer shed their antlers annually, and hence antlers may provide a time-resolved environmental archive for fallout radionuclides. The radiochemical procedure is based on a Pu separation step by anion exchange (Dowex 1 × 8) and a subsequent U purification by extraction chromatography using UTEVA(®). The samples were measured by Accelerator Mass Spectrometry at the VERA facility (University of Vienna). In addition to the (236)U and (239)Pu concentrations, the (240)Pu/(239)Pu isotopic ratios were determined with a mean value of 0.172 ± 0.023 which is in agreement with the ratio of global fallout (∼0.18). Rather high (236)U/(238)U ratios of the order of 10(-6) were observed. These measured ratios, where the (236)U arises only from global fallout, have implications for the use of the (236)U/(238)U ratio as a fingerprint for nuclear accidents or releases from nuclear facilities. Our investigations have shown the potential to use antlers as a temporally resolved archive for the uptake of actinides from the environment.

  15. The regenerating antler blastema: the derivative of stem cells resident in a pedicle stump.

    Science.gov (United States)

    Li, Chunyi; Chu, Wenhui

    2016-01-01

    Antlers of the deer are the only mammalian organs that can fully grow back once lost from their pedicles, hence offer the only opportunity to learn how nature has bestowed mammalian epimorphic regeneration. Investigations have demonstrated that it is the proliferation and differentiation of pedicle periosteal cells (PPCs), but not dedifferentiation of the local differentiated cells, that give rise to the antler blastema. PPCs express key embryonic stem cell markers and can be induced to differentiate into multiple cell lineages, so are termed antler stem cells. Further research has found that PPCs can initiate antler regeneration only when they have interacted with cells of the pedicle skin. Histologically, the process of early antler regeneration resembles that of healing of a mouse leg stump wound. However what sets these two apart is the difference in proliferation potential between the PPCs and the periosteal cells of the long bone. We believe that if we can impart a greater proliferation potential to the long bone periosteal cells, we might be able to achieve the dream of regenerating limbs in mammals.

  16. Manganese Supplementation in Deer under Balanced Diet Increases Impact Energy and Contents in Minerals of Antler Bone Tissue.

    Science.gov (United States)

    Cappelli, Jamil; Garcia, Andrés; Ceacero, Francisco; Gomez, Santiago; Luna, Salvador; Gallego, Laureano; Gambin, Pablo; Landete-Castillejos, Tomás

    2015-01-01

    Bone ash, collagen, Ca and P composition, are considered the main factors affecting mechanical properties in bones. However, a series of studies in bone and antler have shown that some trace minerals, such as manganese, may play a role whose importance exceeds what may be expected considering their low content. A previous study showed that a reduction in manganese in antlers during a year of late winter frosts led to generalized antler breakage in Spain, which included a reduction of 30% of cortical thickness, 27% reduction in impact energy, and 10% reduction in work to peak force. Starting for this observation, we experimentally studied the effects of manganese supplementation in adults and yearling (yearlings) red deer under a balanced diet. Subjects were 29 deer of different age classes (adult n = 19, yearlings n = 10) that were divided in a manganese injected group (n = 14) and a control group (n = 15). Antler content in ashes and minerals, intrinsic mechanical properties and cross section structure were examined at 4 points along the antler beam. A one way ANOVA (mean per antler) showed that in yearlings, manganese supplementation only increased its content and that of Fe. However, in adults, Mn supplementation increased the mean content per antler of Ca, Na, P, B, Co, Cu, K, Mn, Ni, Se (while Si content was reduced), and impact work but not Young's modulus of elasticity, bending strength or work to peak force. A GLM series on characteristics in the uppermost part examined in the antler, often showing physiological exhaustion and depletion of body stores, showed also a 16% increase in work to peak force in the antlers of the treated group. Thus, manganese supplementation altered mineral composition of antler and improved structure and some mechanical properties despite animals having a balanced diet.

  17. Determination of Sex Hormones in Antler Velvet by High Performance Liquid Chromatography Tandem Mass Spectrometry

    Institute of Scientific and Technical Information of China (English)

    LU Chun-mei; WANG Ming-tai; MU Jun; BAI Yu-ping; DU Jian-shi; ZHANG Han-qi; WANG Jian-wei

    2012-01-01

    Eighteen sex hormones in antler velvet were determined by high performance liquid chromatography tandem mass spectrometry.The solid phase extraction was applied to eliminating the matrix effect.The experimental conditions were examined and optimized.Under the optimal conditions,the proposed method provides the good linearities and determination limits(0.2-1.0 μg/kg)of the analytes investigated.The recoveries ranging from 72.3% to 149.5% were obtained for the target analytes at two concentration levels.This method was applied to the determination of eighteen sex hormones in different kinds of antler velvet samples and the obtained results are satisfactory.The results indicate that the proposed method is suitable for the determination of sex hormones in antler velvet samples.

  18. Geohydrology of the Antlers aquifer (Cretaceous), southeastern Oklahoma

    Science.gov (United States)

    Hart, Donald L.; Davis, Robert E.

    1981-01-01

    The Antlers aquifer, which consists of as much as 900 feet of friable sandstone, silt, clay, and shale, crops out in an area of 1,860 square miles and underlies about 4,400 square miles in southeastern Oklahoma. Precipitation ranges from 35 to 50 inches per year across the outcrop area, which is well suited to allow high rates of infiltration. The aquifer contains an estimated 31,600,000 acre-feet of water having less than 1,000 milligrams per liter dissolved solids. The average saturated sand thickness is 250 feet. Aquifer tests in the confined part of the aquifer give an average storage coefficient of 0.0005 and an average transmissivity of 1,480 feet squared per day. The estimated specific yield of the unconfined part of the aquifer is 0.15; the transmissivity has not been determined. Large-capacity wells tapping the aquifer commonly yield 100 to 500 gallons per minute; the maximum measured yield is 1,700 gallons per minute. Water usage from the aquifer is very small owing to the availability of an abundance of surface water. Water quality throughout the central and northern part of the aquifer is generally acceptable for municipal use. A few wells, however, yield water containing concentrations of iron and manganese exceeding the limit recommended for municipal use by the National Academy of Sciences and National Academy of Engineering (1972).

  19. Urban networks and Arctic outlands: Craft specialists and reindeer antler in Viking towns

    DEFF Research Database (Denmark)

    Ashby, Steven P.; Coutu, Ashley N.; Sindbæk, Søren Michael

    2015-01-01

    This paper presents the results of the use of a minimally destructive biomolecular technique to explore the resource networks behind one of the first specialized urban crafts in early mediaeval northern Europe: the manufacture of composite combs of deer antler. The research incorporates the large...

  20. Mechanistic aspects of fracture and R-curve behavior in elk antler bone

    Energy Technology Data Exchange (ETDEWEB)

    Launey, Maximilien E.; Chen, Po-Yu; McKittrick, Joanna; Ritchie, Robert O.

    2009-11-23

    Bone is an adaptative material that is designed for different functional requirements; indeed, bones have a variety of properties depending on their role in the body. To understand the mechanical response of bone requires the elucidation of its structure-function relationships. Here, we examine the fracture toughness of compact bone of elk antler which is an extremely fast growing primary bone designed for a totally different function than human (secondary) bone. We find that antler in the transverse (breaking) orientation is one of the toughest biological materials known. Its resistance to fracture is achieved during crack growth (extrinsically) by a combination of gross crack deflection/twisting and crack bridging via uncracked 'ligaments' in the crack wake, both mechanisms activated by microcracking primarily at lamellar boundaries. We present an assessment of the toughening mechanisms acting in antler as compared to human cortical bone, and identify an enhanced role of inelastic deformation in antler which further contributes to its (intrinsic) toughness.

  1. [The influence of the products prepared from young not ossified antlers marals of siberian red deer on the characteristics of the blood oxygen-supplying system in the athletes during the contest season].

    Science.gov (United States)

    Zaĭtsev, A A; Barabash, L V; Smirnova, I N; Abdulkina, N G; Kremeno, S V; Naumov, A O; Vereshchagina, S V; Shteĭnerdt, S V

    2012-01-01

    The objective of the present study was to estimate the influence of the products prepared from young not ossified antlers marals of Siberian red deer on the characteristics of the blood oxygen-supplying system in the athletes undergoing heavy physical loads during the contest season. It was shown that the use of such preparations promotes correction of humoral characteristics reflecting the development of iron-deficient conditions.

  2. Isolation and characterization of peptidoglycan recognition protein 1 from antler base of sika deer (Cervus nippon).

    Science.gov (United States)

    Jiang, Wei; Yin, Yongguang; Zhou, Yajun; He, Guidan; Qi, Yue

    2014-03-01

    Peptidoglycan recognition proteins (PGRPs) are secreted innate immunity pattern recognition molecules. In this study, a new peptidoglycan recognition protein 1 named cnPGRP1 was isolated from an antler base of sika deer Cervus nippon. The antler base antimicrobial proteins (AAP) were subjected to consecutive chromatographic methods connected to Sephadex G-25 gel filtration column (CM) anion-exchange column, and RP-HPLC. The molecular weight of cnPGRP1 was 17.2 kDa under SDS-PAGE, and peptide mass fingerprint analysis by MALDI-TOF-MS as peptidoglycan recognition protein 1 matched to Dasypus novemcinctus. The matched amino acids sequences were RLYEIIQKWPHYRA. Both Gram-positive and Gram-negative bacteria can be killed by cnPGRP1 in the 50-250 μg/mL range through in vitro. Furthermore, cnPGRP1 has been found to bind Gram-positive bacteria, Gram-negative bacteria, and even fungus.

  3. IGF1 regulates RUNX1 expression via IRS1/2: Implications for antler chondrocyte differentiation.

    Science.gov (United States)

    Yang, Zhan-Qing; Zhang, Hong-Liang; Duan, Cui-Cui; Geng, Shuang; Wang, Kai; Yu, Hai-Fan; Yue, Zhan-Peng; Guo, Bin

    2017-03-19

    Although IGF1 is important for the proliferation and differentiation of chondrocytes, its underlying molecular mechanism is still unknown. Here we addressed the physiologic function of IGF1 in antler cartilage and explored the interplay of IGF1, IRS1/2 and RUNX1 in chondrocyte differentiation. The results showed that IGF1 was highly expressed in antler chondrocytes. Exogenous rIGF1 could increase the proliferation of chondrocytes and cell proportion in the S phase, whereas IGF1R inhibitor PQ401 abrogated the induction by rIGF1. Simultaneously, IGF1 could stimulate the expression of IHH which was a well-known marker for prehypertrophic chondrocytes. Further analysis evidenced that IGF1 regulated the expression of IRS1/2 whose silencing resulted in a rise of IHH mRNA levels, but the regulation was impeded by PQ401. Knockdown of IRS1 or IRS2 with specific siRNA could greatly enhance rIGF1-induced chondrocyte differentiation and reduce the expression of RUNX1. Extraneous rRUNX1 might rescue the effects of IRS1 or IRS2 siRNA on the differentiation. In antler chondrocytes, IGF1 played a role in modulating the expression of RUNX1 through IGF1R. Moreover, attenuation of RUNX1 expression advanced the differentiation elicited by rIGF1, while administration of rRUNX1 to chondrocytes treated with IGF1 siRNA or PQ401 reduced their differentiation. Additionally, siRNA-mediated downregulation of IRS1 or IRS2 in the chondrocytes impaired the interaction between IGF1 and RUNX1. Collectively, IGF1 could promote the proliferation and differentiation of antler chondrocytes. Furthermore, IRS1/2 might act downstream of IGF1 to regulate chondrocyte differentiation through targeting RUNX1.

  4. Effects of Velvet Antler with Blood on Bone in Ovariectomized Rats

    Directory of Open Access Journals (Sweden)

    Ching-Chiung Wang

    2012-09-01

    Full Text Available In traditional Chinese medicine (TCM, both velvet antlers (VA and VA blood can tonify qi, essence, and marrow, nourish the blood, and invigorate bones and tendons. In TCM, the combination of VA and VA blood is believed to have superior pharmacological effects. Scientific evidence supporting the traditional therapeutic preference for redder antler is needed. The effectiveness of the combination therapy of VA middle sections (VAMs and VA blood (VAM-B was first examined in promoting proliferation of mouse osteoblastic cells (MC3T3-E1. The anti-osteoporotic activity of VAM-B (ratio of VAM:VA blood = 1:0.2 was evaluated with ovariectomized (OVX rats at a dose of 0.2 g/kg. In VAM-B-treated OVX rats, the body weight decreased 10.7%, and the strength of vertebrae and the femur respectively increased 18.1% and 15.4%, compared to the control. VAM-B treatment also recovered the estrogen-related loss of the right tibial trabecular bone microarchitecture. Alkaline phosphatase (ALP significantly decreased, but estradiol did not significantly change in serum of VAM-B-treated OVX rats. We also provide an effective strategy to enhance the anti-osteoporotic activity of VAM. In conclusion, our results provide scientific evidence supporting the traditional therapeutic preference of redder antler and indicate that VAM-B is a potential therapeutic agent for managing osteoporosis.

  5. Antler and Body Size in Black-Tailed Deer: An Analysis of Cohort Effects

    Directory of Open Access Journals (Sweden)

    Johanna C. Thalmann

    2015-01-01

    Full Text Available For long-lived species, environmental factors experienced early in life can have lasting effects persisting into adulthood. Large herbivores can be susceptible to cohort-wide declines in fitness as a result of decreases in forage availability, because of extrinsic factors, including extreme climate or high population densities. To examine effects of cohort-specific extrinsic factors on size of adults, we performed a retrospective analysis on harvest data of 450 male black-tailed deer (Odocoileus hemionus columbianus over 19 years in central California, USA. We determined that population density of females had a more dominant effect than did precipitation on body size of males. Harvest of female deer resulted in increases in the overall size of males, even though a 6-year drought occurred during that treatment period. Body size was most influenced by female population density early in life, while antler size was highly affected by both weather early in life and the year directly before harvest. This study provides insights that improve our understanding of the role of cohort effects in body and antler size by cervids; and, in particular, that reduction in female population density can have a profound effect on the body and antler size of male deer.

  6. Can red deer antlers be used as an indicator of environmental and edible tissues' trace element contamination?

    Science.gov (United States)

    Giżejewska, Aleksandra; Szkoda, Józef; Nawrocka, Agnieszka; Żmudzki, Jan; Giżejewski, Zygmunt

    2017-03-21

    Venison is an attractive product for consumers concerned with healthy lifestyle; however, it can contain high levels of toxic elements, and therefore, it is a possible source of hazardous contaminants in human diet. Antlers are suitable bioindicators of environmental metal contamination, and herein, we assessed the ability of trace element levels in antlers to indicate levels in edible soft tissues. We determined the concentrations of lead (Pb), cadmium (Cd), mercury (Hg), arsenic (As), copper (Cu), zinc (Zn), and iron (Fe) in the liver, kidney, muscle, and antlers of 14 free-ranging red deer (Cervus elaphus) from northeastern Poland using atomic absorption spectrometry. We found the highest concentrations of Pb (0.321 ± 0.165 mg/kg), As (0.045 ± 0.074 mg/kg), Zn (105.31 ± 16.33 mg/kg), and Fe (220.92 ± 117.18 mg/kg) in antlers; of Cd (4.974 ± 1.90 mg/kg) and Hg (0.048 ± 0.102 mg/kg) in kidney; and of Cu (7.29 ± 7.02 mg/kg) in the liver. A positive relationship between concentrations in antlers and muscle was found only for Cu (p = 0.001), and it therefore appears that red deer antlers cannot be used as an index for element concentrations in soft tissues. While our results confirm that the Mazury region is little polluted, consumption of red deer offal from this area should be limited according to extant legal limits set for livestock consumption.

  7. Biological and social outcomes of antler point restriction harvest regulations for white-tailed deer

    Science.gov (United States)

    Wallingford, Bret D.; Diefenbach, Duane R.; Long, Eric S.; Rosenberry, Christopher S.; Alt, Gary

    2017-01-01

    Selective harvest criteria, such as antler point restrictions (APRs), have been used to regulate harvest of male ungulates; however, comprehensive evaluation of the biological and social responses to this management strategy is lacking. In 2002, Pennsylvania adopted new APRs for white-tailed deer (Odocoileus virginianus) that required, depending on wildlife management unit, ≥3 or ≥4 points on 1 antler for legal harvest. Historically, harvest rates of subadult (1.5 yr old) and adult (≥2.5 yr old) antlered males averaged 0.80. Antler point restrictions were designed to protect ≥50% of subadult males from harvest. Most adult males remained legal for harvest. We estimated harvest rates, survival rates, and cause-specific mortality of radio-collared male deer (453 subadults, 103 adults) in 2 wildlife management units (Armstrong and Centre counties) to evaluate biological efficacy of APRs to increase recruitment of adult males during 2002–2005. We administered statewide deer hunter surveys before and after each hunting season over the same 3 years to evaluate hunter attitudes toward APRs. We conducted 2 types of surveys: a simple random sample of all license buyers for each survey and a longitudinal panel of hunters who completed all 6 surveys. At the same time APRs were implemented, the Pennsylvania Game Commission (PGC) increased antlerless harvests to reduce deer density to meet deer management goals.Survival rates varied by month and age but not between study areas or among years after implementation of APRs. Monthly survival rates for subadults ranged from 0.64 to 0.97 during hunting seasons and 0.95 to 0.99 during the non-hunting period. Annual survival of subadults was 0.46 (95% CI = 0.41–0.52). Adult monthly survival rates ranged from 0.36 to 0.95 during hunting seasons and we had no mortalities during the non-hunting period. Annual survival of adults was 0.28 (95% CI = 0.22–0.35). Antler point restrictions successfully reduced harvest

  8. Observations on Sambar Rusa unicolor (Cetartiodactyla: Cervidae stags during hard and velvet stages of antler cycle in captivity

    Directory of Open Access Journals (Sweden)

    V.V. Savanth

    2011-10-01

    Full Text Available This research was carried out at the State Museum and Zoo, Thrissur, Kerala, India from June to October, 2009. The objective was to observe and record the physical and behavioural changes in Sambar Deer Rusa unicolor stags linked to their territorial display during various stages of the breeding cycle. In total, there were 70 Sambar in the enclosure, at the commencement of the study, of which 22 were males including 16 adult stags. Six stags were selected for the study. Observations were made by focal animal sampling technique. An ethogram was devised and behavioural patterns were indicated on it. The behavioural score derived from the ethogram was significantly higher in stags in their hard antler stage when compared to the stags in the velvet stage. The stags in the hard antler stage were more massive, had bigger antlers, darker coat colour, thicker neck, larger scrotum and maintained a larger ‘harem’ in comparison to the velvet stage stags which preferred a rather subdued life. The most dominant stags in the hard antler stage had up to 17 female members in his territory. As the stags in velvet entered the rut season, the dominant stag had up to 19 females in his territory. The study is expected to be useful to evolve strategies to identify and reduce a few males not contributing in breeding in any particular enclosure and thus curtail expenses in management of cervids in captivity.

  9. Effects of p21 Gene Down-Regulation through RNAi on Antler Stem Cells In Vitro.

    Science.gov (United States)

    Guo, Qianqian; Wang, Datao; Liu, Zhen; Li, Chunyi

    2015-01-01

    Cell cycle is an integral part of cell proliferation, and consists mainly of four phases, G1, S, G2 and M. The p21 protein, a cyclin dependent kinase inhibitor, plays a key role in regulating cell cyclevia G1 phase control. Cells capable of epimorphic regeneration have G2/M accumulation as their distinctive feature, whilst the majority of somatic cells rest at G1 phase. To investigate the role played byp21 in antler regeneration, we studied the cell cycle distribution of antler stem cells (ASCs), via down-regulation of p21 in vitro using RNAi. The results showed that ASCs had high levels of p21 mRNA expression and rested at G1 phase, which was comparable to the control somatic cells. Down-regulation of p21 did not result in ASC cell cycle re-distribution toward G2/M accumulation, but DNA damage and apoptosis of the ASCs significantly increased and the process of cell aging was slowed. These findings suggest that the ASCs may have evolved to use an alternative, p21-independent cell cycle regulation mechanism. Also a unique p21-dependent inhibitory effect may control DNA damage as a protective mechanism to ensure the fast proliferating ASCs do not become dysplastic/cancerous. Understanding of the mechanism underlying the role played by p21 in the ASCs could give insight into a mammalian system where epimorphic regeneration is initiated whilst the genome stability is effectively maintained.

  10. Effects of p21 Gene Down-Regulation through RNAi on Antler Stem Cells In Vitro.

    Directory of Open Access Journals (Sweden)

    Qianqian Guo

    Full Text Available Cell cycle is an integral part of cell proliferation, and consists mainly of four phases, G1, S, G2 and M. The p21 protein, a cyclin dependent kinase inhibitor, plays a key role in regulating cell cyclevia G1 phase control. Cells capable of epimorphic regeneration have G2/M accumulation as their distinctive feature, whilst the majority of somatic cells rest at G1 phase. To investigate the role played byp21 in antler regeneration, we studied the cell cycle distribution of antler stem cells (ASCs, via down-regulation of p21 in vitro using RNAi. The results showed that ASCs had high levels of p21 mRNA expression and rested at G1 phase, which was comparable to the control somatic cells. Down-regulation of p21 did not result in ASC cell cycle re-distribution toward G2/M accumulation, but DNA damage and apoptosis of the ASCs significantly increased and the process of cell aging was slowed. These findings suggest that the ASCs may have evolved to use an alternative, p21-independent cell cycle regulation mechanism. Also a unique p21-dependent inhibitory effect may control DNA damage as a protective mechanism to ensure the fast proliferating ASCs do not become dysplastic/cancerous. Understanding of the mechanism underlying the role played by p21 in the ASCs could give insight into a mammalian system where epimorphic regeneration is initiated whilst the genome stability is effectively maintained.

  11. Effects of p21 Gene Down-Regulation through RNAi on Antler Stem Cells In Vitro

    Science.gov (United States)

    Guo, Qianqian; Wang, Datao; Liu, Zhen; Li, Chunyi

    2015-01-01

    Cell cycle is an integral part of cell proliferation, and consists mainly of four phases, G1, S, G2 and M. The p21 protein, a cyclin dependent kinase inhibitor, plays a key role in regulating cell cyclevia G1 phase control. Cells capable of epimorphic regeneration have G2/M accumulation as their distinctive feature, whilst the majority of somatic cells rest at G1 phase. To investigate the role played byp21 in antler regeneration, we studied the cell cycle distribution of antler stem cells (ASCs), via down-regulation of p21 in vitro using RNAi. The results showed that ASCs had high levels of p21 mRNA expression and rested at G1 phase, which was comparable to the control somatic cells. Down-regulation of p21 did not result in ASC cell cycle re-distribution toward G2/M accumulation, but DNA damage and apoptosis of the ASCs significantly increased and the process of cell aging was slowed. These findings suggest that the ASCs may have evolved to use an alternative, p21-independent cell cycle regulation mechanism. Also a unique p21-dependent inhibitory effect may control DNA damage as a protective mechanism to ensure the fast proliferating ASCs do not become dysplastic/cancerous. Understanding of the mechanism underlying the role played by p21 in the ASCs could give insight into a mammalian system where epimorphic regeneration is initiated whilst the genome stability is effectively maintained. PMID:26308075

  12. ATRA Signaling Regulates the Expression of COL9A1 through BMP2-WNT4-RUNX1 Pathway in Antler Chondrocytes.

    Science.gov (United States)

    Zhang, Hong-Liang; Guo, Bin; Yang, Zhan-Qing; Duan, Cui-Cui; Geng, Shuang; Wang, Kai; Yu, Hai-Fan; Yue, Zhan-Peng

    2017-09-01

    Although all-trans retinoic acid (ATRA) is involved in the regulation of cartilage growth and development, its regulatory mechanisms remain unknown. Here, we showed that ATRA could induce the expression of COL9A1 in antler chondrocytes. Silencing of cellular retinoic acid binding protein 2 (CRABP2) could impede the ATRA-induced upregulation of COL9A1, whereas overexpression of CRABP2 presented the opposite effect. RARα agonist Am80 induced the expression of COL9A1, whereas treatment with RARα antagonist Ro 41-5253 or RXRα small-interfering RNA (siRNA) caused an obvious blockage of ATRA on COL9A1. In antler chondrocytes, CYP26A1 and CYP26B1 weakened the sensitivity of ATRA to COL9A1. Simultaneously, Bone morphogenetic protein 2 (BMP2) and WNT4 mediated the regulation of ATRA on COL9A1 expression. Knockdown of WNT4 could abrogate the inhibitory effect of BMP2 overexpression on COL9A1. Conversely, constitutive expression of WNT4 reversed the upregulation of COL9A1 elicited by BMP2 siRNA. Together these data indicated that WNT4 might act downstream of BMP2 to mediate the effect of ATRA on COL9A1 expression. Further analysis evidenced that attenuation of runt-related transcription factor 1 (RUNX1) could prevent the stimulation of ATRA on COL9A1 expression, while exogenous rRUNX1 further enhanced this effectiveness. Moreover, RUNX1 might serve as an intermediate to mediate the regulation of BMP2 and WNT4 on COL9A1 expression. Collectively, ATRA signaling might regulate the expression of COL9A1 through BMP2-WNT4-RUNX1 pathway. © 2017 Wiley Periodicals, Inc.

  13. Deer Antler Extract Improves Fatigue Effect through Altering the Expression of Genes Related to Muscle Strength in Skeletal Muscle of Mice

    Directory of Open Access Journals (Sweden)

    Jaw-Chyun Chen

    2014-01-01

    Full Text Available Deer antler is a well-known traditional Chinese medicine used in Asian countries for the tonic and the improvement of aging symptoms. The present study was designed to investigate the antifatigue effect and mechanism of Formosan sambar deer tip antler extract (FSDTAE. The swimming times to exhaustion of mice administered FSDTAE (8.2 mg/day for 28 days were apparently longer than those of the vehicle-treated mice in forced swim test. However, the indicators of fatigue, such as the reduction in glucose level and the increases in blood urea nitrogen and lactic acid levels, were not significantly inhibited by FSDTAE. Therefore, microarray analysis was further used to examine the anti-fatigue mechanism of FSDTAE. We selected genes with fold changes >2 or <−2 in skeletal muscle for pathway analysis. FSDTAE-affected genes were involved in 9 different signaling pathways, such as GnRH signaling pathway and insulin signaling pathway. All of the significantly expressed genes were classified into 8 different categories by their functions. The most enriched category was muscular system, and 6 upregulated genes, such as troponin I, troponin T1, cysteine and glycine-rich protein 2, myosin heavy polypeptide 7, tropomyosin 2, and myomesin family member 3, were responsible for the development and contraction of muscle. Real-time PCR analysis indicated that FSDTAE increased troponins mRNA expression in skeletal muscle. In conclusion, our findings suggested that FSDTAE might increase the muscle strength through the upregulation of genes responsible for muscle contraction and consequently exhibited the anti-fatigue effect in mice.

  14. The antler-like appendages of the primitive deer Dicrocerus elegans: morphology, growth cycle, ontogeny, and sexual dimorphism

    Directory of Open Access Journals (Sweden)

    Andrés, M.

    2011-12-01

    Full Text Available Males and many females of the primitive deer Dicrocerus elegans from Sansan (Middle Miocene, France bore antler-like appendages consisting of a simple-branched protoantler growing from a rather long pedicle and are decorated with ridges and furrows. The protoantler capacity to be rejected and subsequently re-grow is clearly evidenced by the presence of both pedicle and protoantler cast specimens. The youngest appendage is a long, laterally flattened shaft whose apex is usually forked with no appreciable limit between the pedicle and the protoantler. In females, the anterior and posterior appendage margins form a more acute angle than that of males, and are more parallel when viewed laterally. After the first casting, the protoantler base is larger than the pedicle top and a coronet-like structure appears developed only around the medial side. With successive castings, the pedicles become shorter and their section is more circular, while protoantlers become much bigger, and have much longer and more separated branches. Branches of females are shorter than those of males, especially the anterior one, and appear in a straight line, instead of being bent. In oldest appendages, the branches are shorter and more similar in size. Accessory branches and irregularities of this basic morphology are common. The separation between both sex morphotypes appears clearly evidenced by Discriminant and Principal Component Analyses. Histological features point to important differences with true antlers and suggest that casting could not occur annually. A core of spongy bone trabeculae is not developed. Once growth is completed, the mineralization progress from the core to the periphery and when the final ‘velvet’ protoantler becomes completely petrified, the tissues dies and the velvet-like skin is cleaned. A high degree of both wear and polish of the branch apices evidence the hard, bare, dead protoantler phase before casting. Due to the complete growth cycle

  15. Bone regeneration strategy inspired by the study of calcification behavior in deer antler.

    Science.gov (United States)

    Shi, Haishan; Yu, Tao; Li, Zhaoyang; Lu, William; Zhang, Ming; Ye, Jiandong

    2015-12-01

    Bone regeneration has attracted much attention from various researchers and inspired numerous strategies for bone formation. In this study, rapid calcification of deer antlers was studied to unravel bone biology by investigating mineral composition, morphology and microstructure. Calcification model was hypothesized and preliminarily established by in vitro experiments. In our model, mineral deposition and phase conversions in the gel matrix were mimicked. Results revealed that mineral metabolism including deposition and phase conversion plays key roles in calcification in vivo, which inspired the bone regeneration strategy with three main components, i.e. enhanced mineral nucleation, mineral ions sources and crystals habits. Rapid mineral metabolism of implant apatite biomaterials was supposed as the critical aspect of bone regeneration. This study will provide a relatively ideal model for peer bone regeneration studies.

  16. Full length cDNA cloning and expression analysis of annexinA2 gene from deer antler tissue

    Institute of Scientific and Technical Information of China (English)

    Li Hao; Xianghong Xiao; Heping Li

    2014-01-01

    ANXA2(AnnexinA2), a calcium-dependent phospholipid bind-ing protein, is involved in various Ca2+-related biological activities. In the present study, full-length cDNA of ANXA2 was isolated from the velvet antler tip tissue of sika deer (Cervus nippon hortulorum);the amino acid sequence and gene expression was analyzed by using bioinformatics and real-time reverse transcriptase polymerase chain reaction (RT-PCR) techniques. Nucleotide sequence analysis reveals that the full-length cDNA of the ANXA2 gene was 1372 bp, of which 1020 bp was in the open-reading frame (ORF) encoding 339 amino acids; its relative mo-lecular weight was 38.3 kDa; and isoelectric point was 6.72. Sequence analysis indicates that the protein includes four conserved tan-dem-duplication ANX domains. The gene-accession nucleotide sequence number in GenBank is JX315571. Expression analysis by RT-PCR re-veals that ANXA2 gene expression has a significant positive correlation with the antler-tissue mineralization process, indicating that this gene may play an important role in the regulation of antler-tissue mineraliza-tion.

  17. Pilose antler polypeptides promote chondrocyte proliferation via the tyrosine kinase signaling pathway

    Directory of Open Access Journals (Sweden)

    Lin Jian-Hua

    2011-11-01

    Full Text Available Abstract Background Pilose antler polypeptides (PAP have been reported to promote chondrocyte proliferation. However, the underlying mechanism remains unclear. The present study was to investigate the effects of PAP on the proliferation of chondrocytes and its underlying mechanism. Methods Chondrocytes isolated from the knee of Zealand white rabbits were cultured. The second generation chondrocytes were collected and identified using safranin-O staining. The chondrocytes were divided into the following 4 groups including serum-free, PAP, genistein (an inhibitor of tyrosine kinases, and PAP plus genistein group. Cell viability was analyzed using the MTT assay. The cell cycle distribution of the chondrocytes was analyzed by flow cytometry. The expression levels of cyclin A was detected using immunocytochemical staining. Results No significant difference was observed between serum-free and genistein group. Treatment of the cultures with PAP produced a significant dose-dependent increase in cell viability, the percentage proportion of chondrocytes in the S phase and Cyclin A expression as well. However, the promoting effect of PAP on chondrocyte proliferation were dose-dependently inhibited by genistein, whereas genistein alone had no effect on proliferation of isolated chondrocytes. Conclusions The data demonstrate that PAP promotes chondrocyte proliferation with the increased cell number, percentage proportion of chondrocytes in S phase and expression of protein cyclin A via the TK signaling pathway.

  18. Pilose antler peptide protects osteoblasts from inflammatory and oxidative injury through EGF/EGFR signaling.

    Science.gov (United States)

    Chunhui, Yang; Wenjun, Cai; Hui, Wen; Liquan, Sha; Changwei, Zhao; Tianzhu, Zhang; Wenhai, Zhao

    2017-02-16

    Epidermal growth factor (EGF)/EFG receptor (EGFR) signaling plays an important role in the osteoblastogenesis. The potential effects of pilose antler peptide (PAP) on osteoblast cell damages was investigated in our present study through EGF/EGFR signaling. In MC3T3-E1 osteoblastic cells, PAP treatment significantly inhibited the production of inflammatory cytokines by decreasing the levels of serum proinflammatory cytokines interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). PAP treatment also alleviated the oxidative responses as indicated by increased activities of catalase (SOD) and decreased levels of malondialdehyde (MDA). EGF inhibition, by siRNA knockdown, almost abolished PAP-induced osteoblast cytoprotection against inflammation and oxidant stress. Further, our results showed that PAP stimulated the nuclear erythroid factor 2-related factor 2 (Nrf2)2/heme oxygenase-1(HO-1) signaling, and inhibited the activation of uclear factor kappa B (NF-κB) pathway in MC3T3-E1 cells. On the other hand, EGF siRNA knockdown inhibited PAP-induced cytoprotection, which decreased the expression of Nrf-2, HO-1 and increased the level of p-NF-κBp65, p-IκBα in MC3T3-E1 cells. Thus, our research demonstrated that PAP protects osteoblasts from inflammatory and oxidative injury through EGF/EGFR signaling.

  19. First insights into the identification of bone and antler tools used in the indirect percussion and pressure techniques during the early postglacial

    DEFF Research Database (Denmark)

    David, Eva; Sørensen, Mikkel

    2016-01-01

    With the interest for the technological options that were taken by the prehistoric groups to subsist, there is a field of research left empty in terms of archaeological records dated to the 8th and 7th millennia cal BC. It concerns the tool kit made from bone and antler used in Europe by stone...... in the southern Scandinavia at ca. 7300 cal BC. Results are promising and experiments enabling characterization of the bone and antler tools used in the debitage by pressure and indirect percussion will be soon undertaken....

  20. Effect of the Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei on the Prevention of an Allergic Airway Response in Mice

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    Ching-Yun Kuo

    2012-01-01

    Full Text Available Two mouse models were used to assay the antiallergic effects of the velvet antler (VA of Formosan sambar deer (Cervus unicolor swinhoei in this study. The results using the ovalbumin- (OVA- sensitized mouse model showed that the levels of total IgE and OVA-specific IgE were reduced after VA powder was administrated for 4 weeks. In addition, the ex vivo results indicated that the secretion of T helper cell 1 (Th1, regulatory T (Treg, and Th17 cytokines by splenocytes was significantly increased (P<0.05 when VA powder was administered to the mice. Furthermore, OVA-allergic asthma mice that have been orally administrated with VA powder showed a strong inhibition of Th2 cytokine and proinflammatory cytokine production in bronchoalveolar fluid compared to control mice. An increase in the regulatory T-cell population of splenocytes in the allergic asthma mice after oral administration of VA was also observed. All the features of the asthmatic phenotype, including airway inflammation and the development of airway hyperresponsiveness, were reduced by treatment with VA. These findings support the hypothesis that oral feeding of VA may be an effective way of alleviating asthmatic symptoms in humans.

  1. HEPATOPROTECTIVE ACTION OF POLAR LIPIDS OF MARAL ANTLERS AND PEAT IN EXPERIMENTAL LIVER DAMAGE CAUSED BY ISONIAZIDE AND PARACETAMOL

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    A. I. Yatsenkov

    2013-01-01

    Full Text Available In experimental liver pathology caused by isoniazide or paracetamol administration to albino rats lipids derived from maral antlers and peat decreased the blood activity of aminotransferases, γ-glutamyltranspeptidase, acid and alkaline phosphatases, phospholipase А, content of common bilirubin, activated the detoxication of biliribin, ammonium and phenols, inhibited the liver formation of dienic conjugates, Schiff’s bases, malonic dialdehyde, improve the reduced glutathione function. Maral anthlers and peat lipids in effective doses 30 and 60 mg/kg had the more pronounced hepatoprotective and antioxidant action than lipids in dose 10 mg/kg and essentiale forte N.

  2. The Protective Effects of Sika Deer Antler Protein on Cisplatin-Induced Nephrotoxicity

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    Huihai Yang

    2017-08-01

    Full Text Available Background/Aims: This study measured the effect of Sika deer (Cervus nippon Temminck antler protein (SDAPR, glycoproteins (SDAG, and polysaccharides (SDAPO on cisplatin-induced cytotoxicity in HEK 293 cells, and investigated the effect of SDAPR against cisplatin-induced nephrotoxicity in mice. Methods: Cell viability was measured by MTT assay. ICR mice were randomly divided into five groups: control, cisplatin with vehicle, and cisplatin with SDAPR at three concentrations: 5, 10, or 20 mg/kg, p.o., 10 d. Cisplatin was injected on 7th day (25 mg/kg, i.p.. Renal function, oxidative stress, levels of inflammatory factors, and expression of apoptosis-related proteins were measured in vivo. Renal tissues were stained with TUNEL and H&E to observe renal cell apoptosis and pathological changes. Results: Pretreatment with SDAPR (125-2000 µg/mL significantly improved cell viability, with an EC50 of approximately 1000 µg/mL. SDAPR also ameliorated cisplatin-induced histopatholo- gic changes, and decreased blood urea nitrogen (BUN and creatinine (Cr (P < 0.05. Western blotting analysis showed SDAPR clearly decreased expression levels of cleaved-caspase-3 and Bax, and increased the expression level of Bcl-2 (P < 0.01. Additionally, SDAPR markedly regulated oxidative stress markers and inflammatory cytokines (P<0.05. TUNEL staining showed decreased apoptosis after SDAPR treatment (P < 0.01. Conclusions: These results indicate that SDAPR can be an effective dietary supplement, to relieve cisplatin-induced nephrotoxicity by improved antioxidase activity, suppressed inflammation, and inhibited apoptosis in vivo.

  3. A new species of Dyoros (Brachiopoda; Chonetoidea) from Nevada (United States) and stratigraphic implications for the Pennsylvanian and Permian Antler Overlap assemblage [Une nouvelle espèce de Dyoros (Brachiopoda; Chonetoidea) du Nevada (États-Unis) et implications stratigraphiques pour le Complexe chevauchant d'Antler (Pennsylvanien et Permien)

    Science.gov (United States)

    Racheboeuf, Patrick R.; Moore, Thomas E.; Blodgett, Robert B.

    2004-01-01

    Newly discovered fossil localities in coarse-grained deposits of the Pennsylvanian and Permian Antler overlap assemblage in the southern Shoshone Range, north-central Nevada have yielded a low-diversity assemblage consisting chiefly of a new species of chonetoidean brachiopod: Dyoros (Lissosia) nevadaensis nov. sp. The subgenus Dyoros (Lissosia), is known from Leonardian and lower Guadalupian strata in North America, mainly in Texas. The coarse-grained lithology of the host strata, their unconformable relation on deformed lower Paleozoic rocks, and the Leonardian and(or) lower Guadalupian age indicated by Dyoros (Lissosia) provide evidence that host strata are younger than strata of the Antler overlap assemblage in nearby areas of the southern Shoshone Range and suggest that an unconformity of local extent may be present within the overlap assemblage. The fossil age ranges and lithologic data suggest that the host strata may be correlative with the Guadalupian Edna Mountain Formation, an unconformity-bounded unit that forms the upper part of the Antler sequence in the Battle Mountain area to the north. This correlation suggests that the unconformity beneath these strata may have regional extent in north-central Nevada. The origin of the inferred regional unconformity is unknown and may have resulted from relative changes of sea level or regional extensional or contractional tectonism in the area of the former Antler highlands, which forms the substrate for the Antler overlap assemblage. ?? 2004 Elsevier SAS. All rights reserved.

  4. Treatment for intractable anemia with the traditional Chinese medicines Hominis Placenta and Cervi Cornus Colla (deer antler glue

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    Yasuyo Hijikata

    2009-05-01

    Full Text Available Yasuyo Hijikata1, Takashi Kano2, Lu Xi31Toyodo Hijikata Clinic, Osaka, Japan; 2Kano Clinic, Osaka city, Osaka, Japan; 3Traditional Chinese Medicine Institute, Si-chuan Province, ChinaObjective: Intractable anemia, such as aplastic anemia or that presumably associated with chronic herpes virus infections, sometimes require bone marrow transplant. We investigated the use of traditional Chinese medicine (TCM for the treatment of intractable anemia. Method: Placenta Hominis (PH, steam boiled and roasted, and Cervi Cornus Colla (deer antler glue has been used in China for hundreds of years to treat anemia. After consent was obtained, we prescribed these two materials for a 74-year-old female with aplastic anemia and a 26-year-old male with presumably a virus-induced anemia. Concomitant conventional therapy was continued in both patients as prescribed by their respective attending physicians. Conclusion: Conventional therapy with steroid hormones, immunosuppressive drugs, platelet and erythrocyte transfusions were not effective in these patients. In addition, both patients suffered from serious side effects. In two patients, ingestion of Placenta Hominis and Cervi Cornus Colla with TCM prescriptions increased the platelet and enhanced the hemoglobin concentration in several months of therapy accompanied by a dramatic improvement in quality of life. The addition to conventional therapy of PH and Cervi Cornus Colla, the latter of which is very easy to obtain, may be one of the potentially advantageous choices in case of otherwise intractable anemia.Keywords: placenta, antler glue, Cervi Cornus Colla, anemia, aplastic anemia

  5. Historical biomonitoring of fluoride pollution by determining fluoride contents in roe deer (Capreolus capreolus L.) antlers and mandibles in the vicinity of the largest Slovene thermal power plant.

    Science.gov (United States)

    Jelenko, Ida; Pokorny, Boštjan

    2010-12-15

    Roe deer antlers/mandibles are a useful tool for determination of ambient fluoride pollution. Antlers have a well-defined annual cycle of growth, therefore they represent a natural standardisation of samples during winter months. On the contrary, mandibles accumulate fluorides during the whole life of an organism, thus they reflect aggregated effect of fluoride pollution trough the life-span of an organism. Both tissues are easily available; mandibles are often systematically collected with the purpose of cognitive management and control, and antlers could be gathered from private well-dated hunters' collections. Considering these benefits, fluoride contents were measured in 141 antlers (period 1960-2007) and 220 mandibles (period 1997-2009) of roe deer, shot in the vicinity of the largest Slovene Thermal Power Plant of Šoštanj (ŠTPP) as one of the major sources of fluorides in Slovenia. Fluoride contents in antlers significantly differed among age categories, and ranged from 110 to 1210 mg/kg in yearlings, 130 to 2340 mg/kg in young adults, and 250 to 2590 mg/kg in older adults, respectively. Fluoride levels in mandibles were also significantly different among age categories, and ranged from 30.0 to 227 mg/kg in fawns, 33.8 to 383 mg/kg in yearlings, and 61.5 to 1020 mg/kg in adults, respectively. Comparison of these results with previously reported fluoride contents in antlers and mandibles of roe deer from different areas of Europe revealed that the study area has never been extensively contaminated with fluorides. Moreover, trends of fluoride contents in both tissues confirmed a significant decrease of fluoride pollution in the area after the years 1995 and 2000, when flue-gas cleaning devices were constructed on the ŠTPP. Indeed, highly positive correlations between annual emissions from the ŠTPP and mean annual fluoride contents in antlers/mandibles confirmed that both tissues may be a useful tool for assessing temporal trends in ambient fluoride

  6. 鹿茸线粒体DNA的指纹鉴定研究%Identification of Velvet Antler by Mitochondrial DNA Fingerprint

    Institute of Scientific and Technical Information of China (English)

    谷玉娟; 张丽华; 傅桂莲

    2013-01-01

    OBJECTIVE To compare specific primer method and random amplified polymorphic DNA ( RAPD) method for identification of Velvet Antler, thus to choose a simpler method. METHODS DNA samples were extracted from sika deer antler, wild deer antler, reideer pilose antler and commercially available Velvet Antler, and then purified and amplified with specific primer amplification and RAPD amplification. RESULTS The sika deer antler, wild deer antler, reideer pilose antler and some of the commercially available Velvet Antler all showed 313 bp segment in the agarose gel with different brightness while the other commercial products did not show this segment. RAPD not only effectively showed positive and negative DNA amplification results, but also showed the difference in PCR products of sika deer antlerwild deer antler with different strip numbers and strip brightness. CONCLUSION RAPD method is more accurate and rapid and it has wide application prospect.%目的 通过鹿茸特异性引物鉴别和随机扩增多态DNA(RAPD)鉴别的比较,选择一种更简便的方法用于鉴别鹿茸.方法 采用盐析法从梅花鹿茸、马鹿茸、驯鹿茸、市售鹿茸等样品中抽提线粒体DNA,并应用试剂盒进行纯化.进行特异性引物扩增和序列测定,同时进行随机扩增多态DNA扩增.结果 梅花鹿茸,马鹿茸,驯鹿茸以及部分市售鹿茸经特异性引物扩增后均可在琼脂糖凝胶中显示313 bp片段,只是条带亮度不同.而其余市售鹿茸无扩增条带;随机扩增多态DNA不仅有效显示阳性与阴性的DNA扩增结果,而且对梅花鹿茸,马鹿茸,驯鹿茸的聚合酶链反应产物的差异,以不同的条带数目和条带亮度得以验证.结论 随机扩增多态DNA鉴别鹿茸真伪的方法更准确快捷,通过随机扩增多态DNA扩增后主条带与梅花鹿茸或马鹿茸扩增的条带大小和亮度一致,则为正品;如不一致,则为《中国药典》规定外的鹿茸或其他混淆品.这种方法

  7. Effects of aging and dietary antler supplementation on the calcium-regulating hormones and bone status in ovariectomized SAMP8 mice.

    Science.gov (United States)

    Chen, Chun-Chi; Liu, Mei-Hui; Wang, Ming-Fu; Chen, Cheng-Chin

    2007-12-31

    This study was conducted to investigate the effects of aging and long-term dietary antler supplementation on the calcium-regulating hormones and bone status in ovariectomized (Ovx) SAMP8 mice. The female SAMP8 mice were divided into four groups (in each group n = 6), Ovx or sham operated at the age of 2 months, and fed with 0.2% antler containing diet or control diet from the age of 2.5 months. The samples were collected at the age of 3, 6, 9, 12, and 15 months, respectively, for physicochemical analyses, biochemical analyses, and the determination of hormones by radioimmunoassay. The results showed that plasma calcium (Ca) concentrations were maintained in a narrow range in all groups throughout the whole experimental period. With aging and/or ovariectomy, plasma parathyroid hormone (PTH) and 1,25-dihydroxycholecalciferol (1,25-(OH)2-D3) levels increased, and plasma phosphorus (P) and calcitonin (CT) levels decreased, and the femoral bone densities and Ca contents increased during the earlier stage, and then decreased gradually in all groups. Plasma PTH and 1,25-(OH)2-D3 levels in the Ovx mice were significantly higher than those in the intact mice, and plasma P concentrations, plasma CT levels, femoral bone densities, and femoral Ca contents in the Ovx mice were significantly lower than those in the intact mice. In addition, the decreases of plasma P levels, plasma CT levels, femoral bone densities, and femoral Ca contents, and the increases of plasma PTH levels were moderated by antler administration in both Ovx and intact mice. However, there was no effect of the dietary antler supplementation on the plasma 1,25-(OH)2-D3 levels in the female mice. It is concluded that prolonged dietary antler supplementation has important positive effects on bone loss with age and/ or ovarian function deficiency.

  8. Velvet antler peptide prevents pressure overload-induced cardiac fibrosis via transforming growth factor (TGF)-β1 pathway inhibition.

    Science.gov (United States)

    Zhao, Lihong; Mi, Yang; Guan, Hongya; Xu, Yan; Mei, Yingwu

    2016-07-15

    Velvet antlers (VAs) are commonly used in traditional Chinese medicine and invigorant and contain many functional components for health promotion. The velvet antler peptide sVAP32 is one of active components in VAs; based on structural study, the sVAP32 interacts with TGF-β1 receptors and disrupts the TGF-β1 pathway. We hypothesized that sVAP32 prevents cardiac fibrosis from pressure overload by blocking TGF-β1 signaling. Sprague-Dawley rats underwent transverse aortic constriction (TAC) or a sham operation. After one month, rats received either sVAP32 (15mg/kg/day) or vehicle for an additional one month. TAC surgery induced significant cardiac dysfunction, fibroblast activation and fibrosis; these effects were improved by treatment with sVAP32. In the heart tissue, TAC remarkably increased the expression of TGF-β1 and connective tissue growth factor (CTGF), reactive oxygen species levels, and the phosphorylation levels of Smad2/3 and extracellular signal-regulated kinases 1/2 (ERK1/2). SVAP32 inhibited the increases in reactive oxygen species levels, CTGF expression and the phosphorylation of Smad2/3 and ERK1/2, but not TGF-β1 expression. In cultured cardiac fibroblasts, angiotensin II (Ang II) had similar effects compared to TAC surgery, such as increases in α-SMA-positive cardiac fibroblasts and collagen synthesis. SVAP32 eliminated these effects by disrupting TGF-β1 binding to its receptors and blocking Ang II/TGF-β1 downstream signaling. These results demonstrated that sVAP32 has anti-fibrotic effects by blocking the TGF-β1 pathway in cardiac fibroblasts.

  9. First Evaluation of the Biologically Active Substances and Antioxidant Potential of Regrowth Velvet Antler by means of Multiple Biochemical Assays

    Directory of Open Access Journals (Sweden)

    Yujiao Tang

    2015-01-01

    Full Text Available We investigated the biologically active substances contained in RVA (regrowth velvet antler by comparing the composition of biologically active substances and antioxidant potential of different antler segments. RVA was subjected to extraction using DW (distilled water. RVA was divided into 3 segments: T-RVA (top RVA, M-RVA (middle RVA, and B-RVA (base RVA. The T-RVA section possessed the greatest amounts of uronic acid (36.251 mg/g, sulfated GAGs (sulfated glycosaminoglycans (555.76 mg/g, sialic acid (111.276 mg/g, uridine (0.957 mg/g, uracil (1.084 mg/g, and hypoxanthine (1.2631 mg/g. In addition, the T-RVA section possessed the strongest antioxidant capacity as determined by DPPH, H2O2 (hydrogen peroxide, hydroxyl, and ABTS (2,2′-azinobis-3-ethylbenzthiazoline-6-sulphonate radical scavenging activity as well as FRAP (ferric reducing antioxidant power and ORAC (oxygen radical absorbance capacity. The values of those were 53.44, 23.09, 34.12, 60.31, and 35.81 TE/μM at 1 mg/mL and 113.57 TE/μM at 20 μg/mL. These results indicate that the T-RVA section possesses the greatest amount of biologically active substances and highest antioxidant potential. This is the first report on the biologically active substances and antioxidant potential of RVA.

  10. WNT4 acts downstream of BMP2 to mediate the regulation of ATRA signaling on RUNX1 expression: Implications for terminal differentiation of antler chondrocytes.

    Science.gov (United States)

    Zhang, Hong-Liang; Yang, Zhan-Qing; Duan, Cui-Cui; Geng, Shuang; Wang, Kai; Yu, Hai-Fan; Yue, Zhan-Peng; Guo, Bin

    2017-04-24

    Although ATRA is involved in regulating the proliferation and differentiation of chondrocytes, its underlying mechanism remains unknown. Here we showed that ATRA could stimulate the proliferation of antler chondrocytes and expression of COL X and MMP13 which were two well-known markers for hypertrophic chondrocytes. Silencing of CRABP2 prevented the induction of ATRA on chondrocyte terminal differentiation, while overexpression of CRABP2 exhibited the opposite effects. CYP26A1 and CYP26B1 weakened the sensitivity of antler chondrocytes to ATRA. Further analysis evidenced that ATRA might induce chondrocyte terminal differentiation and modulate the expression of BMP2, WNT4, and RUNX1 through RARα/RXRα. Knockdown of BMP2 enhanced the induction of ATRA on the expression of COL X and MMP13, whereas overexpression of BMP2 abrogated this effectiveness. WNT4 might mediate the effects of ATRA and BMP2 on chondrocyte terminal differentiation. Dysregulation of BMP2 impaired the regulation of ATRA on WNT4 expression. Administration of ATRA to antler chondrocytes transfected with RUNX1 siRNA failed to induce the differentiation. Conversely, rRUNX1 strengthened the stimulation of ATRA on the expression of COL X and MMP13. Simultaneously, RUNX1 was a downstream effector of BMP2 and WNT4 in chondrocyte terminal differentiation. Moreover, WNT4 might play an important role in the crosstalk between BMP2 and RUNX1. Attenuation of BMP2 or WNT4 enhanced the interaction between ATRA and RUNX1, while constitutive expression of BMP2 or WNT4 reversed the regulation of ATRA on RUNX1. Collectively, WNT4 may act downstream of BMP2 to mediate the effects of ATRA on the terminal differentiation of antler chondrocytes through targeting RUNX1. © 2017 Wiley Periodicals, Inc.

  11. Construction of Full-length cDNA Library for Antler Tip Tissue of Sika Deer%东北梅花鹿鹿茸尖端组织全长cDNA文库的构建

    Institute of Scientific and Technical Information of China (English)

    郝丽; 李和平; 严厉

    2009-01-01

    为克隆出与鹿茸生长发育相关基因的全长序列,采用SMART技术构建了东北梅花鹿鹿茸尖端组织的全长cDNA文库.用SV Total RNA Isolation System试剂盒提取总RNA,以逆转录酶PowerScriptTM 反转录合成第一链cDNA,然后通过LD-PCR合成并扩增ds cDNA.扩增产物经纯化、SfiⅠ酶切、过CHROMA SPIN-400柱去除小片段后,连接到SfiⅠ消化过的pDNR-LIB质粒载体中,最后用电转化法将重组质粒转化到E. coli DH5α内得到原始文库.经测定,构建的原始文库约含有2.56×10~6个重组子,插入片段多在0.5~2kb之间,平均插入片段长度约1.1kb,重组效率接近100%.结果表明,东北梅花鹿鹿茸尖端组织的全长cDNA文库已构建成功.%A study was conducted to construct full-length cDNA library from antler tip tissues of Sika Deer (Cenna nippon hortu-lonun) by SMART technique in order to clone new special genes for development of antler. The total RNA was extracted u-sing SV Total RNA Isolation System. Single-stranded cDNA was synthesized using PowerScripiTM reverse transcriptase,and double-stranded cDNA was synthesized and amplified by long-distance PCR. The PCR products were digested by pro-teinase K and purified. After digestion with Sfi I and size fractionation using CHROMA SPIN -400TM Columns, SMART cDNA was ligated to the Sfi I-digested, dephosphorylated pDNR-LIB vector, and the ligation mixture was transformed into E. call DH5a by electroporation. The primary cDNA library contained 2.56×10~6 independent clones with DNA inserts of 0.5~2. 0 kb, the average size of inserted cDNAs was 1.1 kb, and the recombination percentage was about 100%. Results showed that the full-length cDNA library from antler tip tissues of Sika Deer was successfully constructed.

  12. The Effects of Velvet Antler of Deer on Cardiac Functions of Rats with Heart Failure following Myocardial Infarction

    Directory of Open Access Journals (Sweden)

    Ming-Jing Shao

    2012-01-01

    Full Text Available Velvet antler of deer (VAD is a commonly-used kidney-Yang supplementing traditional Chinese medication. According to the heart-kidney-related theory, heart Yang originates in kidney Yang and heart failure due to heart Yang deficiency can be treated by tonifying kidney Yang. In this study, we investigated therapeutic effects of VAD on cardiac functions in rats with heart failure following myocardial infarction. Forty-eight male Wistar rats were subjected either to left coronary artery ligation (N=36 or to sham operation (N=12. One week after the surgery, rats with heart failure received daily treatment of double-distilled water, captopril or VAD by gavage for consecutively four weeks, while sham-operated animals were given double-distilled water. Ultrasonic echocardiography was adopted to examine cardiac structural and functional parameters and serum brain natriuretic peptide (BNP concentration was measured using radioimmunoassay. We found that VAD partially reversed changes in cardiac functional parameters and serum BNP levels in rats with heart failure. These results provide further evidence for the heart-kidney-related theory and suggest that VAD might be a potentially alternative and complementary medicine for the treatment of heart failure.

  13. The Antiinfective Effects of Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei on Staphylococcus aureus-Infected Mice

    Directory of Open Access Journals (Sweden)

    Ting-Yeu Dai

    2011-01-01

    Full Text Available We assayed the effects of velvet antler (VA of Formosan sambar deer (Cervus unicolor swinhoei and its extracts on the anti-infective activity against pathogenic Staphylococcus aureus in vitro and in vivo in this study. In vitro data indicated that the VA extracts stimulated the proliferation of resting splenocytes and macrophages in a dose-dependent manner up to the highest concentration used (150 μg mL−1. The production of proinflammatory cytokines (TNF-α, IL-6, IL-12 by lipoteichoic acid was significantly suppressed after being cocultured with the VA extracts in a dose-dependent manner. Animal test in S. aureus-infected mice demonstrated that the numbers of bacteria determined in the kidneys and peritoneal lavage fluid of S. aureus-infected mice were significantly higher than those found in the same organs of mice pretreated with the VA samples. Moreover, the highly enhanced phagocytic activity of macrophages was further verified after in vitro treatment with the VA samples. The protective mechanisms of the VA samples might include an immune enhancer and an inflammatory cytokine suppressor.

  14. Simultaneous determination of eleven sex hormones in antler velvet health products by gas chromatography-tandem mass spectrometry%鹿茸保健品中11种性激素的气相色谱-串联质谱法分析

    Institute of Scientific and Technical Information of China (English)

    芦春梅; 王明泰; 牟俊; 卢利军; 周晓

    2011-01-01

    建立了气相色谱-串联质谱法测定鹿茸保健品中11种性激素的分析方法.鹿茸中的性激素经固相萃取富集和净化,经七氟丁酸酐衍生处理.采用DB-5色谱柱(30 m×0.25 mm,0.25μm)、非线性梯度升温程序分离,在串联质谱多反应监测(MRM)模式下检测,外标法定量,实现了11种性激素的有效分离.11种性激素的检出限为1.0~5.0μg/kg,线性相关系数为0.991 6~0.999 9,平均回收率为67.4%~99.1%,相对标准偏差为2.6%~13%.该方法准确,可靠,可满足鹿茸保健品中性激素含量的测定和确证.%A method for the simultaneous determination of 11 sex hormones in antler velvet health products by gas chromatography-tandem mass spectrometry ( GC-MS/MS) was developed. The sex hormones in antler velvet were enriched and purified by solid phase extraction and derivatized with heptafluorobutyric acid anhydride (HFBA). A DB-5 column (30 m xO. 25 mm, 0. 25 μm) with nonlinear gradient program was used in GC separation. The sex hormones were determined in the multiple reaction monitoring mode. The method realized the complete separation of 11 sex hormones. The limits of detection of this method were from 1.0 to 5. 0 (μg/kg for the 11 sex hormones. The correlation coefficients were between 0. 991 6 and 0. 999 9. The recoveries were in the range of 67. 4% -99. 1% with relative standard deviations (RSDs) of 2. 6% - 13%. This method is accurate and reliable for the determination of the sex hormones in antler velvet health products.

  15. Elemental Analysis of Bone, Teeth, Horn and Antler in Different Animal Species Using Non-Invasive Handheld X-Ray Fluorescence.

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    Kittisak Buddhachat

    Full Text Available Mineralized tissues accumulate elements that play crucial roles in animal health. Although elemental content of bone, blood and teeth of human and some animal species have been characterized, data for many others are lacking, as well as species comparisons. Here we describe the distribution of elements in horn (Bovidae, antler (Cervidae, teeth and bone (humerus across a number of species determined by handheld X-ray fluorescence (XRF to better understand differences and potential biological relevance. A difference in elemental profiles between horns and antlers was observed, possibly due to the outer layer of horns being comprised of keratin, whereas antlers are true bone. Species differences in tissue elemental content may be intrinsic, but also related to feeding habits that contribute to mineral accumulation, particularly for toxic heavy metals. One significant finding was a higher level of iron (Fe in the humerus bone of elephants compared to other species. This may be an adaptation of the hematopoietic system by distributing Fe throughout the bone rather than the marrow, as elephant humerus lacks a marrow cavity. We also conducted discriminant analysis and found XRF was capable of distinguishing samples from different species, with humerus bone being the best source for species discrimination. For example, we found a 79.2% correct prediction and success rate of 80% for classification between human and non-human humerus bone. These findings show that handheld XRF can serve as an effective tool for the biological study of elemental composition in mineralized tissue samples and may have a forensic application.

  16. Immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi).

    Science.gov (United States)

    Kohguchi, Michihiro; Kunikata, Toshio; Watanabe, Hikaru; Kudo, Naoki; Shibuya, Takashi; Ishihara, Tatsuya; Iwaki, Kanso; Ikeda, Masao; Fukuda, Shigeharu; Kurimoto, Masashi

    2004-04-01

    The immuno-potentiating effects of the antler-shaped fruiting body of Ganoderma lucidum (Rokkaku-Reishi, RR), which has been used as a traditional supplement for human health, were investigated in mice. BALB/c mice were administered orally with RR for 3 days at a dose of 50 mg/kg or 500 mg/kg, and interferon-gamma (IFN-gamma) production by splenocytes in response to lipopolysaccharide (LPS) was examined on day 4. The oral administration of 500 mg/kg of RR resulted in a significant increase (p<0.05) in IFN-gamma production. Stimulation of splenic adherent cells from these mice with LPS also resulted in a significant increase (p<0.05) in interleukin-12 (IL-12) production compared with that from the control mice, suggesting that splenic macrophages were activated by RR administration. Furthermore, 500 mg/kg of RR administered for 14 days resulted in a significant increase (p<0.05) in IFN-gamma production by splenocytes in response to both LPS and concanavalin A (Con A). These results suggest that not only splenic macrophages but also T cells were activated by the long-term treatment with RR in vivo. On the other hand, the production of interleukin-4 (IL-4), which is known as an allergic disease-related cytokine, was not affected by the long-term treatment with RR. Our results suggest that the oral administration of RR resulted in Th1-associated immuno-potentiating activities in vivo.

  17. Spin and chirality effects in antler-topology processes at high energy e{sup +}e{sup -} colliders

    Energy Technology Data Exchange (ETDEWEB)

    Choi, S.Y. [Chonbuk National University, Department of Physics, Jeonbuk (Korea, Republic of); University of Pittsburgh, Department of Physics and Astronomy, Pittsburgh Particle physics, Astrophysics, and Cosmology Center, Pittsburgh, PA (United States); Christensen, N.D. [Illinois State University, Department of Physics, Normal, IL (United States); Salmon, D.; Wang, X. [University of Pittsburgh, Department of Physics and Astronomy, Pittsburgh Particle physics, Astrophysics, and Cosmology Center, Pittsburgh, PA (United States)

    2015-10-15

    We perform a model-independent investigation of spin and chirality correlation effects in the antler-topology processes e{sup +}e{sup -} → P{sup +}P{sup -} → (l{sup +}D{sup 0})(l{sup +} anti D{sup 0}) at highenergy e{sup +}e{sup -} colliders with polarized beams. Generally the production process e{sup +}e{sup -} → P{sup +}P{sup -} can occur not only through the s-channel exchange of vector bosons, V{sup 0}, including the neutral Standard Model (SM) gauge bosons, γ and Z, but also through the s- and t-channel exchanges of new neutral states, S{sup 0} and T{sup 0}, and the u-channel exchange of new doubly charged states, U{sup --}. The general set of (nonchiral) three-point couplings of the new particles and leptons allowed in a renormalizable quantum field theory is considered. The general spin and chirality analysis is based on the threshold behavior of the excitation curves for P{sup +}P{sup -} pair production in e{sup +}e{sup -} collisions with longitudinal- and transverse-polarized beams, the angular distributions in the production process and also the production-decay angular correlations. In the first step, we present the observables in the helicity formalism. Subsequently, we show how a set of observables can be designed for determining the spins and chiral structures of the new particles without any model assumptions. Finally, taking into account a typical set of approximately chiral invariant scenarios, we demonstrate how the spin and chirality effects can be probed experimentally at a high-energy e{sup +}e{sup -} collider. (orig.)

  18. Spin and chirality effects in antler-topology processes at high energy e{sup +}e{sup -} colliders

    Energy Technology Data Exchange (ETDEWEB)

    Choi, S. Y. [Department of Physics, Chonbuk National University, 561-756, Jeonbuk (Korea, Republic of); Department of Physics and Astronomy, Pittsburgh Particle physics, Astrophysics, and Cosmology Center, University of Pittsburgh, 15260, Pittsburgh, PA (United States); Christensen, N. D. [Department of Physics, Illinois State University, 61790, Normal, IL (United States); Salmon, D.; Wang, X., E-mail: xiw77@pitt.edu [Department of Physics and Astronomy, Pittsburgh Particle physics, Astrophysics, and Cosmology Center, University of Pittsburgh, 15260, Pittsburgh, PA (United States)

    2015-10-06

    We perform a model-independent investigation of spin and chirality correlation effects in the antler-topology processes e{sup +}e{sup -}→P{sup +}P{sup -}→(ℓ{sup +}D{sup 0})(ℓ{sup -}D{sup -bar0}) at high-energy e{sup +}e{sup -} colliders with polarized beams. Generally the production process e{sup +}e{sup -}→P{sup +}P{sup -} can occur not only through the s-channel exchange of vector bosons, V{sup 0}, including the neutral Standard Model (SM) gauge bosons, γ and Z, but also through the s- and t-channel exchanges of new neutral states, S{sup 0} and T{sup 0}, and the u-channel exchange of new doubly charged states, U{sup --}. The general set of (non-chiral) three-point couplings of the new particles and leptons allowed in a renormalizable quantum field theory is considered. The general spin and chirality analysis is based on the threshold behavior of the excitation curves for P{sup +}P{sup -} pair production in e{sup +}e{sup -} collisions with longitudinal- and transverse-polarized beams, the angular distributions in the production process and also the production-decay angular correlations. In the first step, we present the observables in the helicity formalism. Subsequently, we show how a set of observables can be designed for determining the spins and chiral structures of the new particles without any model assumptions. Finally, taking into account a typical set of approximately chiral invariant scenarios, we demonstrate how the spin and chirality effects can be probed experimentally at a high-energy e{sup +}e{sup -} collider.

  19. Collagen Content of Velvet Antlers at Different Growth Stages and Optimization of Extraction Process%不同生长阶段鹿茸中胶原含量比较及提取条件优化

    Institute of Scientific and Technical Information of China (English)

    赵玉红; 金秀明; 王珊珊

    2012-01-01

    Velvet antlers were selected as raw materials to extract collagen using enzyme pepsin. Collagen contents at different growth stages were also compared. Results showed that content and the yield of collagen in two branched antler were 65.8 mg/g and 4.53%, respectively, which were significantly higher than three branched antler (P 〈 0.05). Factors of extraction time, enzyme addition and liquid-solid ratio were chosen to research the effects on yield of collagen and Box-Behnken experiment was designed to optimize the extraction conditions. The results showed that extraction time for 52 h, enzyme addition with 5%, liquid-solid ratio at 23:1 (mL/g) were the optimal conditions, the yield of collagen in two-branched antler was 5.92%.%以梅花鹿鹿茸为原料,研究不同生长阶段鹿茸中胶原含量及胶原提取效果并确定适宜提取条件。采用胃蛋白酶法提取胶原,采用Box-Behnken中心组合试验设计优化胶原提取条件。结果表明:二杠茸中胶原含量和得率均高于毛桃茸和三杈茸,分别为65.8mg/g和4.53%;胶原提取适宜工艺条件为提取时间52h、酶用量5%、液料比23:1(mL/g),在此条件下鹿茸胶原得率为5.92%。

  20. Histologi dan Histomorfometri Testis dan Epididimis Muncak (Muntiacus muntjak muntjak pada Periode Ranggah Keras (HISTOLOGY AND HISTOMORPHOMETRY OF THE TESTIS AND EPIDIDYMIS OF MUNTJAC (MUNTIACUS MUNTJAK MUNTJAK DURING HARD ANTLER PERIOD

    Directory of Open Access Journals (Sweden)

    Sri Wahyuni

    2013-07-01

    Full Text Available The objective of this study was to describe the histology and histomorphometry of testis and epididymisof muntjac (Muntiacus muntjak muntjak during hard antler period. The tissues of the testis and epididymisof an adult male muntjac were processed for histological examination and stained with haematoxylineosine(HE. The parenchyma of muntjac’s testis during hard antler period showed tubuli seminiferi waslined with germinal epithelium: spermatogonia, spermatocyte, spermatid that differentiated intospermatozoa. Sertoli cells were found among the germinal cells. In addition, Leydig cells were foundaround the blood vessel of interstitial tissue along with macrophages. Diameter of the seminiferous tubuleand epithelial thickness were 176,60±7,06 ?m and 50,27±3,62 ?m respectively. The epididymal duct wassubdivided into three segments: caput, corpus and cauda. They were lined predominantly withpseudostratified columnar epithelium which was varied in its thickness. The largest diameter of epididymalduct was found in cauda region (324,26±25,79 ?m, while caput epididymidis had the thickest of epithelialcell (62,21±4,21 ?m and tended to ce thinner in corpus (49,53±3,01 ?m and cauda epididymidis(16,30±2,27?m. The density of spermatozoa was observed the most in the lumen of cauda region comparedto caput and corpus epididymidis. In conclusion, the structure of histology and histomorphometry of theseminiferous tubule of testis and epididymal duct of muntjac were similar with small ruminants andother Cervidae during hard antler period.

  1. Determination of the Content of Water-soluble Proteins in Antler Herbs and its Influence Factors%马鹿茸中水溶性蛋白质的含量测定及其影响因素考察

    Institute of Scientific and Technical Information of China (English)

    黄帮蕊; 李佳芮; 王春贺; 金洋; 马方圆; 金向群; 高兵; 常彤

    2016-01-01

    To establish a method for the determination of the content of water -soluble proteins in velvet antler herbs ,and explore the effect of drying methods ,storage time and species on its content .Water soluble proteins in velvet antler herbs were extracted through maceration in low temperature water and dyed by Bradford method .The content of it was determined by visible spectrophotometer .The content of water-soluble protein in the sample has a good linear relationship in the range of 540μg/mL-40μg/mL in terms of bovine serum albumin .The regression e-quation is y=0.0231x+0.1114(R2=0.995) and the recovery rate is 99.33% ,RSD is 0.86% .Moreover ,the content of water-soluble pro-tein in velvet antler alters during storage and in high temperature drying ,which is lower than that in the low temperature drying .Water-soluble protein content among different species is also different .The content determination of water-soluble protein in velvet antler by Bradford method is simple and reliable ,so it can be used as a method of quality control of velvet antler herbs .Storage time and drying method also have influence on water-soluble protein content in antler ,so antler herbs production process should be paid attention to .%建立马鹿茸中水溶性蛋白质含量测定方法,并探讨干燥方法、储存时间对其含量的影响。采用考马斯亮蓝显色法测定马鹿茸中水溶性蛋白质的含量。样品中水溶性蛋白质的含量以牛血清蛋白计在5μg/mL~40μg/mL范围内具有良好线性关系,回归方程为y=0.0231x+0.1114( R2=0.995),平均回收率为99.33%,RSD为0.86%;马鹿茸水溶性蛋白含量随储存时间延长而下降,高温干燥比低温干燥含量低。采用考马斯亮蓝显色法测定马鹿茸水溶性蛋白质的含量,方法简便、可靠,可作为马鹿茸质量控制的方法。存储时间、干燥方法对马鹿茸水溶性蛋白含量有影响,在马鹿茸生产过程中要注意。

  2. 鹿茸顶端组织端粒酶活性检测及TERT基因的差异表达%Detecting Telomerase Activity and Differential Expression Analysis of TERT Gene in Antler Tip Tissue

    Institute of Scientific and Technical Information of China (English)

    胡薇; 李沐; 李婷; 田玉华; 孟星宇; 刘宁

    2013-01-01

    为了检测梅花鹿鹿茸顶端组织不同部位的端粒酶活性及端粒酶逆转录酶( TERT )基因的mRNA表达水平,分离鹿茸顶端组织的茸皮层、间充质层及软骨层,并进行细胞培养,利用TRAP银染法测定不同部位的端粒酶活性。再利用TRIzol试剂法分别提取茸皮层、间充质和软骨细胞的总RNA,逆转录合成cDNA。根据Gen-Bank已发表的相关序列设计梅花鹿TERT基因部分序列特异引物并克隆TERT基因,采用相对荧光定量Real-time PCR法检测TERT在鹿茸顶端不同部位细胞的表达丰度。结果表明:在鹿茸顶端组织茸皮层、间充质层和软骨层均检测到了端粒酶活性,其中间充质层的端粒酶活性最高,软骨层次之,茸皮层端粒酶活性最低;而体外培养的不同代数间充质细胞的端粒酶活性无明显差异。成功获得了鹿茸组织TERT基因部分编码区cDNA序列,该基因长915 bp,编码305个AA;与牛、羊TERT基因进行同源性分析显示,核苷酸序列分别为94.89%和94.31%;氨基酸序列分别为92.16%和92.11%。相对荧光定量PCR差异分析发现,TERT基因在鹿茸顶端不同部位组织均有表达。其中,在间充质组织的表达水平高于软骨和茸皮层组织。%In order to detect the telomerase activity of different parts of top tissue of sika deer antler and mRNA expression of TERT gene, the skin of antler, mesenchymal layer and layer of cartilage were separated from the antler tip tissue and cul-tured.TRAP silver staining was improved to detect the telomerase activity of different parts.And total RNA of cartilage layer and the skin layer of antler and mesenchymal layer were isolated by TRIzol reagent to use reverse transcription for synthesizing the cDNA.According to the correlation sequences that GenBank published, sika TERT gene partial sequence special primers were designed and the gene was cloned.The relative fluorescence

  3. 麋鹿角醇提液对雄鼠性腺功能的影响%Effect of Elk antlers ethanolic fluid extract on gonad function of male mice

    Institute of Scientific and Technical Information of China (English)

    成海龙; 田郡; 陆晓东; 秦红兵; 朱清

    2009-01-01

    Objective:To investigate the effect of Elk antlers ethanolic fluid extract on gonad function of male mice and make a preliminary research on traditional pharmacological actions of Elk antlers strengthening sexual ability. Methods: Repeated electrical stimulation stress was used to copy sexual dysfunction model mice. The influence of Elk antlers ethanolic fluid extract on mature male mice's ability of capturing female mice was observed. Elk antlers ethanolic fluid extract was given to immature male mice for 10 days, then the weight index of sex organ and accessory sex organ were observed, sperm density and sperm activity were detected, and the levels of testosterone and luteinizing hormone in serum were determined. Results: Elk antlers ethanolic fluid extract could strengthen the sexual ability of stressed mature male mice in capturing female mice. It decreased latency of licking and mounting behavior, and increased the frequency of the licking and mounting behavior. It raised the mass index of testicle in inmature male mice, but had no effect on the weight index of accessory sex organ and the density and activity of sperm. It elevated the level of luteinizing hormone but not testosterone. Conclusion:Elk antlers ethanolic fluid extract has a protective effect on the sexual dysfunction induced by electrical stimulation stress; and it has certain gonadorelin-like function but may not have sex hormone-like function.%目的:观察麋鹿角醇提液对雄性小鼠性腺功能的影响,对麋鹿角传统的壮阳作用进行初步实验研究.方法:以重复电刺激复制应激小鼠性功能低下模型,观察麋鹿角醇提液对成熟雄鼠捕捉雌性小鼠能力的影响.给正常幼龄雄性小鼠连续灌胃给药10d,观察其性器官以及附性器官的脏器质量指数,检测其精子密度和精子活动率,并测定血清中睾酮与促黄体生成素的水平.结果:麋鹿角醇提液能增加应激后雄鼠捕捉雌鼠的能力,能够缩短跨骑潜伏

  4. 马鹿茸水溶性总蛋白提取工艺研究%Optimization of Extraction Technology of Soluble Proteins from Velvet Antler of Cervus elaphus Linnaeus

    Institute of Scientific and Technical Information of China (English)

    周杰

    2016-01-01

    目的:优选鹿茸水溶性蛋白的最佳提取工艺.方法:以马鹿茸为原料,采用组织匀浆结合浸提的方法提取可溶性蛋白,以鹿茸可溶性蛋白得率和含量为评价指标,通过单因素实验研究匀浆方法、匀浆次数、提取溶液浓度和pH对鹿茸可溶性蛋白得率的影响,优化提取工艺.结果:鹿茸可溶性蛋白的最佳提取工艺为,以pH为7,50mmol?L-1的Tris-HCl缓冲溶液为提取溶剂,采用电动匀浆机,匀浆次数为3次.结论:优化得到的提取工艺稳定、可行,可为进一步研究鹿茸蛋白的药理药效提供参考.%Objective To optimize the appropriate extracting technology for soluble proteins from velvet antler.Methods Extracted the soluble proteins with homogenate method, studied the effect of homogenate method, homogenate times, concentration and pH of extraction solvent, using soluble proteins extraction rates and content as the indices. Results: The optimal extraction technology for the soluble proteins was as follows: electric homogenate, the extraction solvent of 50 mmol·L-1, pH of 7.The extraction rate of he soluble proteins from velvet antler was and the content of the soluble proteins was .Conclusion The optimal extraction technology is stable and feasible, and can provide reference for further study on velvet antler.

  5. 荧光标记鹿茸蛋白提取物胃肠道吸收离体实验研究%In vitro study on gastrointestinal absorption of FITC labeled Pilose Antler protein extraction

    Institute of Scientific and Technical Information of China (English)

    张倩; 胡剑江; 周秋丽; 王新月; 王毅

    2011-01-01

    An in vitro detection method of the gastrointestinal absorption of Pilose Antler protein was established for mixed protein activity. Five bands of protein with molecular weight of 17.8-160 kD derived from the Pilose Antler were extracted and sufficiently labeled with FITC (FITC-PE). The stability and variation of FITC-PE in gastrointestinal circumstances were detected by native polyacrylamide gel electrophoresis and confocal laser scanning microscope. Results showed that the main component of FITC-PE kept invariant after being reacted with artificial gastric fluid and artificial intestinal fluid. The fluorescence signal was detected 20 min after administration in the valgus intestinal purse experiment, and three kinds of protein, with molecular weight of 45, 25, and 17.8 kD, were detected in the mixture of absorbent protein. The research laid the foundation for the further in vivo study of Pilose Antler protein. Meanwhile, it would be an in vitro screening method for the absorption, distribution and metabolism of mixed protein from traditional Chinese medicine.%鹿茸是一种名贵的中药,含有丰富的蛋白质及多肽等活性成分,对神经、心血管、免疫、生殖系统有显著的调节作用[1].鹿茸的传统给药方式为口服给药,给药后经消化道相关酶的降解发生一系列的变化,然而,由于检测方法的限制,目前还没有成熟的技术可以对鹿茸中大分子混合物实现活性示踪和综合分析,不能阐明其作用机制及药代动力学信息,因而不能被充分开发利用.

  6. 鹿茸多糖分离纯化及抗氧化活性研究%Purification and antioxidant activity of polysaccharide from velvet antler

    Institute of Scientific and Technical Information of China (English)

    赵玉红; 金秀明; 韩睿

    2012-01-01

    采用DEAE-52离子交换层析和Sepharose CL-6B凝胶排阻层析对鹿茸粗多糖进行分离纯化,并通过对DPPH自由基、羟基自由基(·OH)、超氧阴离子自由基(O2-·)清除能力和还原能力的测定,研究了粗多糖及纯化后多糖的抗氧化能力。结果表明:DEAE-52离子交换层析和Sepharose CL-6B凝胶排阻层析对鹿茸多糖分离效果较好,可以分离纯化得到一种单一多糖;粗多糖和纯化后多糖对DPPH·、·OH、O2-·均有清除作用,且具有一定的还原能力,纯化后多糖抗氧化活性和还原能力均大于粗多糖。%DEAE-52 ion-exchange column chromatography and Sepharose CL-6B gel exclusion chromatography were used to isolate the crude polysaccharide.Antioxidant activities of the crude and purified polysaccharide were evaluated through their capability of scavenging DPPH·,·OH,O-2· radicals and reducing power.The result showed that,DEAE-52 ion-exchange column chromatography and Sepharose CL-6B gel exclusion chromatography were suitable for separating and purifying polysaccharide from velvet antlers,a kind of purified polysaccharide was isolated from the crude polysaccharide.Both of the polysaccharide crude and purified had significant effect on scavenging DPPH·,·OH,O-2· radicals and also had reduction ability.Furthermore purified polysaccharide had more activity antioxidant than crude polysaccharide.

  7. Antilipid peroxidation of polyamines from pilose antler%鹿茸多胺的抗脂质过氧化作用

    Institute of Scientific and Technical Information of China (English)

    陈晓光; 金淑莉; 邸琳; 刘新宇; 张晓宇

    2004-01-01

    目的研究鹿茸多胺的抗氧化作用.方法测定鹿茸多胺在体外对NADPH-维生素C和Fe 2+-半胱氨酸系统诱发的微粒体脂质过氧化反应(MDA形成)的影响,对黄嘌呤-黄嘌呤氧化酶系统超氧阴离子自由基(O-2)产生(还原型细胞色素C形成)的影响,在体内对CCl4和乙醇诱发的小鼠肝脂质过氧化反应(MDA形成)的影响.结果鹿茸多胺在体外能明显抑制NADPH-维生素C和Fe2+-半胱氨酸系统诱发的大鼠脑、肝、肾微粒体脂质过氧化反应(MDA形成),及黄嘌呤-黄嘌呤氧化酶系统O-2的产生(还原型细胞色素C形成).在体内能抑制CCl4和乙醇诱发的小鼠肝脂质过氧化反应(MDA形成).结论鹿茸多胺具有抗氧化作用.%Object To investigate the antioxidant activity of polyamines isolated from pilose antler(paipa).Mthods The effects of PAIPA ON the lipid peroxidation(MDA formation)in microsomes of rat brain,liver ,and kidney induced by NADPH-Vitamine C(Vc)and ferrous-cysteine systems in vitro,the superoxide anion radical production(reduced cytochrome C formation)inxanthine-xanthine oxidase system in vitro,and the CCL4-and ethanol-induced MDA formation in mice liver in vivo were evaluated.Results PAIPA could significantly inhibit the lipid peroxidation(MDA formation)in microsomes of rat brain,liver,and kidney induced by NADPH-Vc and ferrous -cyctein,the superoxide anion radical produc-tion(formation of reduced cytochrome C)in xanthine-oxidase system in vitro,and the CCL4-and ethanol-induced MDA formation in mice liver in vivo.Conclusion PAIPA exhibits an antioxidant activity.

  8. 鹿茸水提物减轻顺铂所致的小鼠肾损伤%Protective effect of aqueous extract of velvet antler on cisplatin-induced nephrotoxicity in mice

    Institute of Scientific and Technical Information of China (English)

    董思敏; 王海璐; 王全凯; 张晶

    2016-01-01

    AIM:To study the protective effect of aqueous extract of 2-branched and 3-branched velvet antler on cisplatin (CDDP)-induced nephrotoxicity in mice .METHODS:The mouse model of renal injury was induced by intra-gastric administration of CDDP at the dose of 15 mg/kg.After treatment, kidney index (KI), serum creatinine (SCr), blood urea nitrogen (BUN), the activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and the content of malondialdehyde ( MDA) in the kidney were determined .The renal pathological changes were observed with HE staining.RESULTS:Aqueous extract of velvet antler at the tested dose markedly decreased BUN , SCr and the content of MDA, and elevated the activity of SOD and GSH-Px in the mice pretreated with CDDP ( P<0.05) .The pathological chan-ges of the renal tissues were improved obviously , and the injury of the epithelial cells of renal tubules was mitigated .The effect of the aqueous extract of 2-branched velvet antler on renal function and cisplatin-induced nephrotoxicity was better than that of 3-branched one at the same concentration .CONCLUSION: The aqueous extract of 2-branched and 3-branched velvet antler has a certain protective effect on cisplatin-induced nephrotoxicity , which may be associated with in-creasing the anti-oxidative capability of mouse renal tissue .%目的:探讨梅花鹿二杠茸和三岔茸水提物对顺铂( CDDP)所致小鼠肾损伤的影响。方法:采用灌胃给药方式,用顺铂(15 mg/kg)诱导小鼠肾损伤模型,测定小鼠肾脏指数(KI)、血清肌酐(SCr)、血尿素氮(BUN)、肾脏组织中超氧化物歧化酶( SOD)和谷胱甘肽过氧化物酶( GSH-Px)活性及丙二醛( MDA)含量,并对肾脏组织进行HE染色,观察肾脏病理学变化,研究梅花鹿二杠茸和三岔茸的水提物各剂量对小鼠肾损伤的影响。结果:与顺铂组相比,各剂量鹿茸水提物可显著降低CDDP诱导肾损伤小鼠SCr

  9. 鹿茸提取物对顺铂诱导人胚肾细胞损伤的影响∗%Effect of Velvet Antler on Human Embryonic Kidney Cell Injury In-duced by Cisplatin

    Institute of Scientific and Technical Information of China (English)

    王婧瑜; 王露露; 李冰; 刘芳芳; 孙长波; 张晶

    2015-01-01

    This experiment was designed to study the effects of pilose antler extractions ( water ex⁃tract, ethanol extract, ether extract, chloroform extract and ethyl acetate extract) to protect HEK293 injury induced by cisplatin( CDDP ) . HEK293 was cultured in vitro and the results were determined by MTT and LDH. Pilose antler extractions can protect CDDP⁃induced injury of HEK293, and the death rate was more than half at the level of (0�083±0�030) mmol/L. After HEK293 cells were in⁃cubated for 24 h with different concentrations of extract of pilose antler, CDDP was joined respec⁃tively. It was found that water extraction has better protection on CDDP⁃induced HEK293, and at the level of 1 mg/mL, the survival rate of cells was 62%( P<0�01) . Water extraction can effectively protect CDDP⁃induced HEK293 and maintain cell activity.%建立顺铂(CDDP)诱导人胚肾成纤维细胞(HEK293)细胞损伤模型,通过MTT和LDH测定,比较不同浓度的鹿茸提取物(水提物,醇提物,乙醚提取物,氯仿提取物,乙酸乙酯提取物)诱导HEK293细胞损伤的保护作用。体外培养HEK293细胞,观察鹿茸提取物对CDDP诱导HEK293细胞生长的影响,并用MTT法和LDH法检测鹿茸对CDDP诱导HEK293细胞死亡率的变化。结果表明:鹿茸提取物能够拮抗CDDP诱发的细胞损伤,具有浓度依赖性,其半数致死浓度为(0�083±0�030) mmol/L。当HEK293细胞与不同浓度鹿茸提取物共同孵育24 h,分别加入CDDP后,检测表明鹿茸水提物较其他溶剂提取物对顺铂诱导损伤的HEK293有较好的保护作用,其质量浓度为1 mg/mL时对顺铂诱导损伤的HEK293细胞的保护作用最强,细胞存活率达到62�0%( P<0�01)。鹿茸水提物对CDDP诱导人胚肾细胞损伤的抑制作用最显著,可有效保护细胞活性。

  10. Effect of antler velvet alcohol extracts on improving learning and memory sbilities in mice%鹿茸醇提物对小鼠学习记忆功能的影响

    Institute of Scientific and Technical Information of China (English)

    赵玉红; 张睿; 潘强

    2012-01-01

    Objective:To investigate the effect of antler velvet alcohol extract(AVAE)on learning and memory in mice.Methods:One hundred and fifty-six male Kunming mice were randomized into control group(12 mice,given salty water),memory obtain stage group,memory consolidate stage group and memory reappearance stage group(48 mice in each group),each group had 3 small groups:high dose,mid dose and low dose group,given alcohol extract of antler velvet dry matter on 1kg/(kg·d),0.5kg/(kg·d)and 0.1kg/(kg·d)respectively.After 30d,each stage's latency and number of errors of jumping platform experiment as well as swimming time and number of errors of water maze were tested,at the same time,the activity of SOD and the content of MDA in mind were evaluated.Results:The AVAE could prolong the latency(P0.01)of jumping platform experiment on each stage as well as decreasing the number of errors(P0.01)obviously,and decrease the swimming time and the number of errors(P0.01,P0.05)of water maze,then increase the activity of SOD(P0.01,P0.05)and decrease the content of MDA in mice brain(P0.01,P0.05).Conclusions:The AVAE had the function of improving learning and memory impairment obviously.%目的:研究鹿茸醇提物(AVAE)对小鼠学习记忆能力的影响。方法:156只昆明种雄性小鼠分成空白组(12只小鼠,灌胃生理盐水)、记忆获取阶段组、记忆巩固阶段组和记忆再现阶段组(每组48只小鼠),各阶段组中的高、中、低剂量组每天每只小鼠分别灌胃鹿茸乙醇提取物的干粉量为1kg/(kg·d)、0.5kg/(kg·d)和0.1kg/(kg·d)。灌胃30d,测定各个记忆阶段小鼠跳台实验的潜伏期及错误次数、水迷宫实验的游出时间及错误次数和小鼠大脑内的SOD酶活力及MDA含量。结果:鹿茸醇提物能明显延长各个阶段小鼠跳台实验的潜伏期(P〈0.01)并减少错误次数(P〈0.01);缩短小鼠水迷宫实

  11. Cloning of a Full-Length cDNA Encoding Insulin-Like Growth Factor I and Its Expression in Antler Tissue%梅花鹿IGF1全长cDNA克隆及在鹿茸组织的表达

    Institute of Scientific and Technical Information of China (English)

    胡薇; 孟星宇; 田玉华; 刘宁

    2011-01-01

    The study was to detect expression of Insulin-Like Growth Factor I(IGF1) from antler tip tissue to provide a theoretical basis for the molecular mechanism of antler growth. Total RNA was isolated from dermis, mesenchyme, pre-cartilage and cartilage layers in growing antler tip tissue respectively. A pair of primers was designed according to the homology region of IGF1 among other species. The cDNA sequence of 1GF1 gene was cloned by RT-PCR technology. Then, real-time PCR was used to detect the expression level of IGF1 in the antler tip. Results showed that the complete coding sequence of IGF1 gene was obtained (GenBank accession No: HQ890468). It has 465 base pairs in length, encoding a predicted protein of 154 amino acids. Bioinformatic analysis based on IGF1 genes of red deer, cattle, sheep, horse, pig, human and mouse showed that the homologies of ICF1 to red deer, cattle and sheep were 99.78% , 98.28% and 97. 85% , and the homologies of protein were 99. 35% , 98. 05% and 97. 40% respectively. Results of fluorescence quantification showed that IGF1 was expressed in all the tested organs in antler tip tissue, but its transcript level in cartilage and pre-cartilage layers was much higher than that in mesenchyme and dermis layers.%为了检测梅花鹿鹿茸组织IGF1基因的mRNA表达水平,利用TRIzol试剂法分别提取鹿茸真皮、间充质、前软骨和软骨组织总RNA,逆转录合成cDNA.根据GenBank已发表的相关序列设计梅花鹿IGFI基因特异引物并克隆IGFI基因,将IGF1基因DNA序列递交GenBank,并利用相对荧光定量Real-time PCR法检测IGF1在鹿茸顶端不同部位组织的转录表达丰度.研究结果表明:成功获得了梅花鹿鹿茸组织IGF1基因全长编码区cDNA(GenBank登录号为HQ890468),该基因长465 bp,编码154aa长度的多肽;与马鹿、牛、羊、马、猪、人和小鼠IGF1基因进行同源性分析显示,IGF1基因与马鹿、牛和羊同源性最高,核苷酸序列分别为99.78% 、98.28

  12. Elevated silver, barium and strontium in antlers, vegetation and soils sourced from CWD cluster areas: do Ag/Ba/Sr piezoelectric crystals represent the transmissible pathogenic agent in TSEs?

    Science.gov (United States)

    Purdey, Mark

    2004-01-01

    High levels of Silver (Ag), Barium (Ba) and Strontium (Sr) and low levels of copper (Cu) have been measured in the antlers, soils and pastures of the deer that are thriving in the chronic wasting disease (CWD) cluster zones in North America in relation to the areas where CWD and other transmissible spongiform encephalopathies (TSEs) have not been reported. The elevations of Ag, Ba and Sr were thought to originate from both natural geochemical and artificial pollutant sources--stemming from the common practise of aerial spraying with 'cloud seeding' Ag or Ba crystal nuclei for rain making in these drought prone areas of North America, the atmospheric spraying with Ba based aerosols for enhancing/refracting radar and radio signal communications as well as the spreading of waste Ba drilling mud from the local oil/gas well industry across pastureland. These metals have subsequently bioconcentrated up the foodchain and into the mammals who are dependent upon the local Cu deficient ecosystems. A dual eco-prerequisite theory is proposed on the aetiology of TSEs which is based upon an Ag, Ba, Sr or Mn replacement binding at the vacant Cu/Zn domains on the cellular prion protein (PrP)/sulphated proteoglycan molecules which impairs the capacities of the brain to protect itself against incoming shockbursts of sound and light energy. Ag/Ba/Sr chelation of free sulphur within the biosystem inhibits the viable synthesis of the sulphur dependent proteoglycans, which results in the overall collapse of the Cu mediated conduction of electric signals along the PrP-proteoglycan signalling pathways; ultimately disrupting GABA type inhibitory currents at the synapses/end plates of the auditory/circadian regulated circuitry, as well as disrupting proteoglycan co-regulation of the growth factor signalling systems which maintain the structural integrity of the nervous system. The resulting Ag, Ba, Sr or Mn based compounds seed piezoelectric crystals which incorporate PrP and ferritin into

  13. Practical development of laboratory of biologics technology of the Palladin Institute of Biochemistry of NAS of Ukraine for the period 1991-2010

    Directory of Open Access Journals (Sweden)

    G. G. Lugovska

    2015-10-01

    Full Text Available The paper presents the results of inventive activity of the Laboratory of Biologics Technology of the Palladin Institute of Biochemistry, NAS of Ukraine, under the leadership of Z.M.Datsenko, Cand.Sc. (Biol., during 1991-2010. The laboratory researchers have developed new technologies for production of medicines of lipid-protein nature, which are based on endogenous complexes of biologically active substances included in the composition of biomembranes of different origin. The researchers have created new technologies for drug PANTOCRINE (for injections and oral administration from antlers of deers and horns of farm animals that have significantly higher biological activity compared with the commercial drug. They have also created new biologically active drugs from antlers with a specific action: HIPPOCAMP, reducing blood pressure in various forms of hypertension, and PANTERON – biological regulator of synthesis of steroid hormones. Further the researchers have developed technologies for obtaining biologically active complexes of various specific action from marine organisms (calamari, clams mussels, shellfish: CALMOFIL and MOLUFIL, therapeutic agents for replacement therapy of surfactant system of the lungs; FILOMEK, the agent for prophylaxis and treatment of a human reproductive system disorders; MOLUSTERON, the glicolipopeptide complex, three individual physiologically active compositions being differentially obtained from the latter: lipopeptide composition – for treatment of hypertension, nucleopeptide one – for treatment of hormonal disorders, and phospholipid – for treatment of lung diseases under the surfactant shortage.

  14. Le travail du bois de cerf à Villeparisis (Seine-et-Marne : un dépotoir au sein d’un atelier de potiers du Bas Empire Antler working at Villeparisis (Seine-et-Marne: a rubbish dump within a potters' workshop of the Late Roman Empire.

    Directory of Open Access Journals (Sweden)

    Franck Mallet

    2008-04-01

    Full Text Available Les fouilles archéologiques menées en 2003 et en 2005 à Villeparisis (Seine-et-Marne dans le centre ancien, ont mis au jour les vestiges d’une zone artisanale du Bas Empire regroupant un atelier de potiers mais également les témoins d’activités diverses, notamment 60 bois de cerfs au sein d’un dépotoir. Ceux-ci sont incomplets et portent de nombreuses traces de travail. Leur analyse n’a pas permis de déterminer les objets façonnés.The excavations, in Villeparisis’ town centre (Seine-et-Marne led in 2003 and 2005, have revealed a large craft area occupied during the Late Romantimes. The remains of a potter’s workshop and 60 red deer antlers have been discovered. These are incomplete and show many traces of work. Their analysis dœs no enable us to determine which artefacts had been made.

  15. Combination of Supercritical Fluid Extraction with Ultrasonic Extraction for Obtaining Sex Hormones and IGF-1 from Antler Velvet%超临界萃取技术结合超声强化技术提取鹿茸中性激素和IGF-1

    Institute of Scientific and Technical Information of China (English)

    周冉; 李淑芬; 张大成

    2009-01-01

    Supercritical CO2 (SC-CO2) extraction technology and ultrasonic technology were used to extract two active sex hormones, estradiol and progesterone, and insulin-like growth factor-1 (IGF-1) from antler velvet. The effects of SC-CO2 extraction condition on the extraction yield and content of sex hormones, the ultrasonic extraction condition on the content of IGF-1 and the SC-CO2 extraction condition on the activity remaining of IGF-1 were studied. The optimal conditions were obtained. The experimental results velvet residue, when the pHIO ammonia-ammonium chloride buffer solution was used as the solvent, the ratio of solvent to sample was 20/1 (volume/mass), the extraction temperature was 0-35℃, and the extraction time was 4×15 min. Under these conditions, 93.68% activity remaining of IGF-1 in the residue was obtained, while little IGF-1 activity exists in traditional residue. The experimental results indicate that the technology of SC-CO2 with co-solvent is of advantage for getting high content sexual hormones and keeping high activity of IGF-1 in the residue, which can not be achieved by traditional extraction methods.

  16. 苗药鹿角壮骨胶囊辅助治疗骨质疏松性椎体压缩骨折46例临床观察%Study on Curative Effect Miao medicine Antler Bone Improvement Capsule Treating Patients with Osteoporotic Vertebral Compression Fracture

    Institute of Scientific and Technical Information of China (English)

    唐广应; 陆永刚; 赵久敏; 张凯

    2016-01-01

    目的:观察苗药鹿角壮骨胶囊辅助治疗骨质疏松性椎体压缩骨折(OVCF)的临床疗效。方法:选取86例 OVCF 患者为研究对象,随机分为对照组40例和治疗组46例。对照组采用 PVP 手术治疗后口服碳酸钙 D3和阿法骨化醇治疗,治疗组在对照组基础上加用苗药鹿角壮骨胶囊治疗,比较观察两组的疗效、骨 CT 值、骨密度值、再次骨折发生情况。结果:治疗组优良率93.47%高于对照组的80.00%,两组优良率比较,差异具有统计学意义(P <0.05);疗程结束后及结束后12个月随访,治疗组 CT 值和骨密度均高于对照组(P<0.05),而再骨折发生率低于对照组(P <0.05)。结论:苗药鹿角壮骨胶囊胶囊辅助治疗骨质疏松性椎体压缩骨折疗效好,且再骨折发生率较低,能明显改善患者的生活质量。%Objective the curative effect Miao medicine antler bone improvement capsule treating patients with OVCF.Method By randomized control test method to randomly divide 86 patients with OVCF control group 40 patients and treatment group 46 patients, the control group was treated by PVP operation,then given calcium carbonate D3 tablets and alfacalcidol capsules,The treatment group was based on basic medication group to plus Lujiao -zhuanggu capsule.Observe groups of patients'CT value,bone density,as well as observe the incidence of re -fracture.Results Compare the clinical effect of two groups,the treatment group with excellent and good rate of 93.47%;The control group with excellent and good rate of 80.00%;Compare the excellent and good rate of two groups,the difference has statistical significance (P <0.05).After and the end of treatment 12 months,the improvement of CT value and bone density of treatment group is significantly higher than what of control group (P <0.05),however,the incidence of re -frac-ture is significantly lower than what of control group (P <0.05).Conclusion The

  17. Development

    DEFF Research Database (Denmark)

    2012-01-01

    reviewing WTO rules addressing development and developing countries and the EU´s application of them......reviewing WTO rules addressing development and developing countries and the EU´s application of them...

  18. Effects of dietary exposure to brominated flame retardant BDE-47 on thyroid condition, gonadal development and growth of zebrafish

    Science.gov (United States)

    Torres, Leticia; Orazio, Carl E.; Peterman, Paul H.; Patino, Reynaldo

    2013-01-01

    Little is known about the effects of brominated flame retardants in teleosts and some of the information currently available is inconsistent. This study examined effects of dietary exposure to 2,2′,4,4′-tetrabromodiphenyl ether (BDE-47) on thyroid condition, body mass and size, and gonadal development of zebrafish. Pubertal, 49-day-old (posthatch) fish were fed diets without BDE-47 (control) or with 1, 5 or 25 μg/g BDE-47/diet. Treatments were conducted in triplicate 30-L tanks each containing 50 zebrafish, and 15 fish per treatment (5 per tank) were sampled at days 40, 80 and 120 of exposure. Measurements were taken of body mass, standard length, head depth and head length. Sex (at 40–120 days of exposure), germ cell stage (at 40 days) and thyroid condition (at 120 days; follicular cell height, colloid depletion, angiogenesis) were histologically determined. Whole-body BDE-47 levels at study completion were within the high end of levels reported in environmentally exposed (wild) fishes. Analysis of variance was used to determine differences among treatments at each sampling time. No effects were observed on thyroid condition or germ cell stage in either sex. Reduced head length was observed in females exposed to BDE-47 at 80 days but not at 40 or 120 days. In males, no apparent effects of BDE-47 were observed at 40 and 80 days, but fish exposed to 25 μg/g had lower body mass at 120 days compared to control fish. These observations suggest that BDE-47 at environmentally relevant whole-body concentrations does not affect thyroid condition or pubertal development of zebrafish but does affect growth during the juvenile-to-adult transition, especially in males.

  19. Reproductive Ecology of Yakima River Hatchery and Wild Spring Chinook and Juvenile-to-Adult PIT-tag Retention; Yakima/Klickitat Fisheries Project Monitoring and Evaluation, 2001 Annual Report.

    Energy Technology Data Exchange (ETDEWEB)

    Knudsen, Curtis M. (Washington Department of Fish and Wildlife, Olympia, WA)

    2002-11-01

    This report is intended to satisfy two concurrent needs: (1) provide a contract deliverable from Oncorh Consulting to the Washington Department of Fish and Wildlife (WDFW), with emphasis on identification of salient results of value to ongoing Yakima/Klickitat Fisheries Project (YKFP) planning, and (2) summarize results of research that have broader scientific relevance. This is the first in an anticipated series of reports that address reproductive ecological research and monitoring of spring chinook in the Yakima River basin. In addition to within-year comparisons, between-year comparisons will be made to determine if traits of the wild Naches basin control population, the naturally spawning population in the upper Yakima River and the hatchery control population are diverging over time. This annual report summarizes data collected between April 1, 2001 and March 31, 2002. In the future, these data will be compared to previous years to identify general trends and make preliminary comparisons.

  20. Myostatin-deficient medaka exhibit a double-muscling phenotype with hyperplasia and hypertrophy, which occur sequentially during post-hatch development.

    Science.gov (United States)

    Chisada, Shin-Ichi; Okamoto, Hiroyuki; Taniguchi, Yoshihito; Kimori, Yoshitaka; Toyoda, Atsushi; Sakaki, Yoshiyuki; Takeda, Shunichi; Yoshiura, Yasutoshi

    2011-11-01

    Myostatin (MSTN) functions as a negative regulator of skeletal muscle mass. In mammals, MSTN-deficient animals result in an increase of skeletal muscle mass with both hyperplasia and hypertrophy. A MSTN gene is highly conserved within the fish species, allowing speculation that MSTN-deficient fish could exhibit a double-muscled phenotype. Some strategies for blocking or knocking down MSTN in adult fish have been already performed; however, these fish show either only hyperplastic or hypertrophic growth in muscle fiber. Therefore, the role of MSTN in fish myogenesis during post-hatch growth remains unclear. To address this question, we have made MSTN-deficient medaka (mstnC315Y) by using the targeting induced local lesions in a genome method. mstnC315Y can reproduce and have the same survival period as WT medaka. Growth rates of WT and mstnC315Y were measured at juvenile (1-2wk post-hatching), post-juvenile (3-7wk post-hatching) and adult (8-16wk post-hatching) stages. In addition, effects of MSTN on skeletal muscle differentiation were investigated at histological and molecular levels at each developmental stage. As a result, mstnC315Y show a significant increase in body weight from the post-juvenile to adult stage. Hyper-morphogenesis of skeletal muscle in mstnC315Y was accomplished due to hyperplastic growth from post-juvenile to early adult stage, followed by hypertrophic growth in the adult stage. Myf-5 and MyoD were up-regulated in mstnC315Y at the hyperplastic growth phase, while myogenin was highly expressed in mstnC315Y at the hypertrophic growth phase. These indicated that MSTN in medaka plays a dual role for muscle fiber development. In conclusion, MSTN in medaka regulates the number and size of muscle fiber in a temporally-controlled manner during posthatch growth.

  1. Preventive and therapeutic effects of antler collagen on osteoporosis ...

    African Journals Online (AJOL)

    GREGORY

    2010-09-20

    Sep 20, 2010 ... from Sika deer velvet on osteoporosis in ovariectomized rats. Histomorphometric indices, serum biochemical parameters and biomechanical properties were measured in .... Compared to the OVX group, the BMD values of.

  2. Suvemaja, Antler Island, Fairy Lake, Ontario / Ants Elken

    Index Scriptorium Estoniae

    Elken, Ants, 1917-2012

    1997-01-01

    Tuli projekteerida suvila kasvavale perele, mis algusest peale kasutamiskõlblikuna areneks koos perekonna laienemisega. Kerged paviljonid meenutavad küla. Ehitati 1966-1989. Arhitekt Elmar Tampõld. Joonised, vaated.

  3. Developed

    Institute of Scientific and Technical Information of China (English)

    LUO; Rui

    2001-01-01

    [1]Antal, S. P., Lahey, R. T. Jr. Flaherty, J. E., Analysis of phase distribution in fully developed laminar bubbly two-phase flow, Int. J. Multiphase Flow, 1991, 17: 635.[2]Nakoryakov, V. E., Kashinsky, O. N., Randin, V. V. et al., Gas-liquid bubbly flow in vertical pipes, Journal of Fluid Engineering, 1996, 118: 377.[3]Kashinsky, O. N., Timkin, L. S., Cartellier, A., Experimental study of 搇aminar?bubbly flows in a vertical pipe, Experiments in Fluids, 1993, 14: 308.[4]Song, Q., Theoretical and experimental research on bubbly flow in a vertical pipe, Ph. D Thesis, Tsinghua University, 1999, Beijing, China.[5]Kataoka, M., Ishii, M., Serizawa, A., Local formulation of interfacial area concentration, Int. J. Multiphase Flow, 1986, 12: 505.[6]Drew, D. A., Mathematical modeling of two-phase flow, Annual Review of Fluid Mechanics, 1983, 15: 261.[7]Nigmatulin, R. I., Spatial averaging in the mechanics of heterogeneous and dispersed systems, Int. J. Multiphase Flow, 1979, 5: 353.[8]Sato, Y., Sadatomi, M., Sekoguchi, K., Momentum and heat transfer in two-phase bubbly flow-I, Int. J. Multiphase Flow, 1981, 7: 167.[9]Ishii, M., Mishima, K., Two-fluid modeling and hydrodynamic constitutive relations, Nucl. Engng. Des., 1984, 82: 107.[10]Drew, D. A., Lahey, R. T. Jr., The virtual mass and lift force on a sphere in rotating and straining invicid flow, Int. J. Multiphase Flow, 1987, 13: 113.[11]Cherkutat, P., McLaughlin, J. B., Wall-induced lift on a sphere, Int. J. Multiphase Flow, 1990, 16: 899.[12]Tomiyama, A., Zun, I., Higaki, H. et al., A three-dimensional particle tracking method for bubbly flow simulation, Nucl. Engng. Des., 1997, 175: 77.[13]Van Wijingaarden, L., The mean rise velocity of pairwise-interacting bubbles in liquid, J. Fluid Mech., 1993, 251: 55.[14]Stuhmiller, J. H., The influence of interfacial pressure on the character of two-phase flow model equations, Int. J. Multiphase Flow, 1977, 3: 551.

  4. Preparation of nano b-tricalcuim phosphate, gelatin and velvet antler polypeptide composites and its effect on the proliferation, differentiation and mineralization in hFOB1.19 cells%纳米磷酸三钙/明胶/鹿茸多肽复合材料的制备及对人成骨细胞增殖、分化及矿化的影响

    Institute of Scientific and Technical Information of China (English)

    刘晓峰; 张郑瑶; 田秀丽; 张瑾; 史祺云; 胡进平; 郭燕川; 邓旭明; 周秋丽

    2013-01-01

    探讨反相微乳液法制备的β-纳米磷酸三钙/明胶/鹿茸多肽复合材料(简称纳米复合材料)对人成骨细胞功能的影响.利用反相微乳液法制备纳米复合材料,扫描电镜观察其形态,EDX与SELDI-TOF-MS分析对复合材料进行表征.采用MTT比色法、茜素红染色法检测纳米复合材料对体外培养的人成骨细胞hFOB1.19的增殖、矿化结节形成的影响;采用全自动生化分析仪检测hFOB细胞碱性磷酸酶活性(ALP).结果表明该纳米复合材料可促进人成骨细胞增殖,提高ALP活性并增加矿化结节形成的数量,可促进人成骨细胞的增殖、分化成熟及矿化.%Abstract:The nano tricalcium phosphate/ gelatin/velvet antler polypeptide (VAP)composite materials (referred as nanocomposites) were prepared by water-in-oil (W/O) emulsion process.The effect of nanocomposites on human osteoblasts was studied in hFOB1.19 cell lines.Nanocomposites were prepared through emulsification-coacervation method in water-in-oil emulsions.The morphology was observed by scanning electron microscope.Characterization of composite spheres was examined by EDX and SELDI-TOF-MS.MTT assay and alizarin red staining were employed to detect the effects of nanocomposites on the proliferation and formation of mineralization nodules formation in hFOB cells,respectively.The alkaline phosphatase(ALP) activity was determined by automatic clinical chemistry analyzer.The results showed that nanocomposites could stimulate human osteoblasts cells proliferation increase ALP activity,and promote the formation of mineralization nodules.

  5. Food science in developing countries.

    Science.gov (United States)

    Brown, N L; Pariser, E R

    1975-05-01

    It is particularly important for us not to lose sight of the fact that people have been around for a long time and that they achieved remarkable technical skills long before Western science was developed. An anonymous writer from the Food and Agriculture Organization has observed: "It is a commonplace that the fundamental discoveries which made civilization possible-fire- making, tool-making, agriculture, building, calculating, writing, money-were all apparently made outside the area which has given us the marvels of modern science" (19). The writer might well have added that it is also commonly overlooked that food technology was not suddenly developed in the 20th century but has been very much a part of the lives of people everywhere ever since they began doing more to their food than gathering it and eating it raw. Lamb's "Essay on Roast Pig" may not be an accurate account of the first conjunction of fire and food, but cooking is a rather ancient practice. Fermentation is another complicated processing technology which is a traditional part of most cultures, particularly those in warm climates-beer, yogurt, cheese, the fish pastes and sauces of Asia, the palm wine of Africa, and soy sauce, are butsome examples. Native Americans, besides accomplishing marvels in plant genetics and crop development, also developed water extraction methods for treating acorns to render the flour palatable and edible, and the alkali method of processing maize. Furthermore, they developed a cure for scurvy-by making a water extraction of pine needles which are rich in ascorbic acid-long before it was first reported by Jacques Cartier in the 16th century. Similarly, calcium-deficient diets of pregnant and nursing women were traditionally successfully supplemented by calcium-rich powdered deer antlers in northern China. Among the Chinese and Greeks, goiter was cured by eating certain kinds of seaweed centuries before the disease was traced to a lack of iodine, and Kenyans learned to

  6. Complete mitochondrial genome of the Antlered sculpin Enophrys diceraus (Scorpaeniformes, Cottidae).

    Science.gov (United States)

    Li, Ang; Munehara, Hiroyuki

    2015-02-01

    The complete mitochondrial genome (mitogenome) sequence of Enophrys diceraus (Cottidae) was determined for the first time by primer walking methods. It was 16,976 bp in length and contains 13 protein-coding genes, 2 ribosomal RNA genes, 22 transfer RNA genes, and a control region (CR). Within the CR, the extended termination-associated sequence, the central conserved sequence block (CSB-F, CSB-E, CSB-D, CSB-C, CSB-B, CSB-A) and the conserved sequence block (CSB-1, CSB-2, CSB-3) were identified. This first mitogenome information among marine sculpins is expected to enrich the knowledge on phylogenetic studies of this taxon.

  7. Petrographic and geochemical characteristics of a section through the Tiva Canyon Tuff at Antler Ridge, Yucca Mountain, Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Singer, F.R.; Widmann, B.L.; Dickerson, R.P. [Science Applications International Corp., Golden, CO (United States); Byers, F.M. Jr. [Geological Survey, Denver, CO (United States)

    1994-12-31

    The Tiva Canyon Tuff of the Paintbrush Group of Miocene age caps much of Yucca Mountain, Nevada and is a compositionally zoned, compound cooling, pyroclastic flow that ranges from a dominantly high-silica rhyolitic base to a quartz-latitic caprock. Petrographic and geochemical studies have focused on rigorously defining the internal stratigraphy of this unit to support the detailed mapping of the Ghost Dance fault and other structures in the central fault block of Yucca Mountain. This study shows that devitrification textures and vapor phase mineralogy, in addition to other physical attributes such as pumice variability (flattening) and crystal content, can be used as distinguishing criteria to better define lithologic zones within the Tiva Canyon Tuff. In addition, the study also shows that the petrographic textures and chemistry of the groundmass vary systematically within recognizable lithologic zones and may be used to characterize and vertically divide litho-stratigraphic zones within the Tiva Canyon Tuff.

  8. Child Development

    Science.gov (United States)

    As children grow older, they develop in several different ways. Child development includes physical, intellectual, social, and emotional changes. Children grow and mature at very different rates. It's ...

  9. Developing Collaborative Product Development Capabilities

    DEFF Research Database (Denmark)

    Mahnke, Volker; Tran, Yen

    2012-01-01

    Collaborative product development capabilities support a company’s product innovation activities. In the context of the fast fashion sector, this paper examines the development of the product development capabilities (PDC) that align product development capabilities in a dual innovation context, ......-level, simultaneous learning processes and highlight the role of human agency in capability development with partners. Building on our analyses, we advance propositions for future research and managerial practices on developing dynamic collaboration capabilities....

  10. 78 FR 45956 - Notice of Inventory Completion: Hamilton County Department of Parks and Recreation, Hamilton...

    Science.gov (United States)

    2013-07-30

    ... lot of antler tine flakers; 1 antler tine tool; 1 antler toggle; 1 lot of antler tool making debris; 1... hook fragment; 1 bone indeterminate tool fragment; 1 bone tool fragment; 1 lot of bone tool making... humpback knife; 1 lot of intermediate bone tool; 4 lots of light and heavy fraction; 1 modified...

  11. Multimobile Development

    CERN Document Server

    Baxter-Reynolds, Matthew

    2010-01-01

    You've developed a killer app for one mobile device - now it's time to maximize your intellectual investment and develop for the full spectrum of mobile platforms and devices. With Multimobile Development, you'll learn how to quickly retool between the iPhone and Android platforms and broaden the interest and audience of your app, without working with burdensome and error-prone compatibility layers and toolkits. Multimobile Development takes you, the developer, through the same mobile software development project on both platforms, learning the differences between and the relative strengths an

  12. Divine development

    DEFF Research Database (Denmark)

    Agarwala, Rina

    2015-01-01

    position in the world system and support poverty alleviation efforts within a neoliberal development framework. Indian-American Muslims draw from their poor status in India to overturn economic inequities within India by shifting India's development rhetoric from identity to class. Collective religious...... identities (expressed through organizations) not only affect the intensity of immigrants’ development efforts, but also their content and ideology. These findings urge us to fold transnational religious organizations into contemporary discussions on migration and development....

  13. Modularizing development

    DEFF Research Database (Denmark)

    Müller, Anders Riel; Doucette, Jamie

    In 2007, South Korea's Ministry of Strategy and Finance (MOSF) and the Korea Development Institute (KDI) launched the Knowledge Sharing Program (KSP) to satisfy the growing interest in Korea's rapid development from high growth economies in East Asia and Africa. The KSP's mandate is "to offer...... as a unique success story of sustainable and equitable development worth emulating. These narratives accord South Korea considerable international status and portray it as a country with recent, hands‐on development expertise that is directly relevant to the needs of developing economies. Furthermore......, the sharing of this expertise is used to foster diplomatic relations with countries to which Korea has growing trade, production, and migrant networks. The KSP thus reflects not only Korea’s entry into international development assistance but also a continuing transition in Korea's own development policies...

  14. Materials Development

    Institute of Scientific and Technical Information of China (English)

    Brian Tomlinson

    2005-01-01

    @@ Introduction Materials development is both a field of study and a practical undertaking. As a field it studies the principles and procedures of the design, implementation and evaluation and adaptation of language teaching materials, by teachers for their own classrooms and by materials writers for sale or distribution. Ideally these two aspects of materials development are interactive in that the theoretical studies inform and are informed by the development and use of classroom materials (e. g. Tomlinson 1998c).

  15. Flower Development

    OpenAIRE

    Alvarez-Buylla, Elena R; Benítez, Mariana; Corvera-Poiré, Adriana; Chaos Cador, Álvaro; de Folter, Stefan; Gamboa de Buen, Alicia; Garay-Arroyo, Adriana; García-Ponce, Berenice; Jaimes-Miranda, Fabiola; Pérez-Ruiz, Rigoberto V.; Piñeyro-Nelson, Alma; Sánchez-Corrales, Yara E.

    2010-01-01

    Flowers are the most complex structures of plants. Studies of Arabidopsis thaliana, which has typical eudicot flowers, have been fundamental in advancing the structural and molecular understanding of flower development. The main processes and stages of Arabidopsis flower development are summarized to provide a framework in which to interpret the detailed molecular genetic studies of genes assigned functions during flower development and is extended to recent genomics studies uncovering the ke...

  16. KENO developments

    Energy Technology Data Exchange (ETDEWEB)

    Hollenbach, D.F.; Landers, N.F.; Petrie, L.M. [Oak Ridge National Lab., TN (United States)

    1997-06-01

    Modifications and developments to the series of KENO multigroup, criticality safety transport codes are very briefly summarized. Three areas are addressed: (1) modifications to KENO-V.a, (2) development of KENO-VI, (3) modifications to the CSAS4 sequence of the SCALE package, and (4) future work on KENO related programs. Minor changes have been made to KENO-V.a, primarily for maintenance. KENO-VI has been developed and will be released soon. A new search type is being developed in SCALE to allow CSAS4 to do a concentration search on a mixture component.

  17. Stamen development.

    NARCIS (Netherlands)

    Keijzer, C.J.

    1986-01-01

    In this thesis the development of the stamen is investigated, using structural and histochemical observations, micromanipulation and in-vitro culture.Formation and exposure of pollen are the two main goals of the developing stamen. The main processes of the pollen formation were already known. In th

  18. Diverting Developments

    DEFF Research Database (Denmark)

    Taudal Poulsen, René

    2013-01-01

    developments in the two industries have diverted after 1970. All the large and medium-sized Danish shipyards have ceased, whereas several equipment suppliers have endured and some have built up strong positions within their respective fields. Focusing on corporate strategies in shipbuilding and marine...... equipment manufacturing, this article examines the diverting developments of the two industries and asks what has caused this divergence?...

  19. Management Development.

    Science.gov (United States)

    1997

    This document contains three papers from a symposium on management development. "LMX (Leader-Member Exchange) Theory, Personality Type, and Management Development" (Janet Z. Burns) reports the results of a study on the similarities and differences in personality type (as outlined in the theories of Carl Jung and Isabel Myers) and its relationship…

  20. Career development

    OpenAIRE

    Langerová, Aneta

    2008-01-01

    Document (1) highlights some of the important career development factors connected with self management and (2) describes proposal, preparation and execution of socio-psychological trainning session of first career development which aims to help high school students find the way to start their working career correctly.

  1. Securing Development

    DEFF Research Database (Denmark)

    Working paper presented at ECPR General Conference 2015, Montréal. Panel: “The Concept of Development in Global Politics 1” (P315), 29 August 2015.......Working paper presented at ECPR General Conference 2015, Montréal. Panel: “The Concept of Development in Global Politics 1” (P315), 29 August 2015....

  2. Speech Development

    Science.gov (United States)

    ... The speech-language pathologist should consistently assess your child’s speech and language development, as well as screen for hearing problems (with ... and caregivers play a vital role in a child’s speech and language development. It is important that you talk to your ...

  3. Representing Development

    DEFF Research Database (Denmark)

    Representing Development presents the different social representations that have formed the idea of development in Western thinking over the past three centuries. Offering an acute perspective on the current state of developmental science and providing constructive insights into future pathways...... and development, addressing their contemporary enactments and reflecting on future theoretical and empirical directions. The first section of the book provides an historical account of early representations of development that, having come from life science, has shaped the way in which developmental science has...... approached development. Section two focuses upon the contemporary issues of developmental psychology, neuroscience and developmental science at large. The final section offers a series of commentaries pointing to the questions opened by the previous chapters, looking to outline the future lines...

  4. Convergent repression of miR156 by sugar and the CDK8 module of Arabidopsis Mediator.

    Science.gov (United States)

    Buendía-Monreal, Manuel; Gillmor, C Stewart

    2017-03-01

    In Arabidopsis, leaves produced during the juvenile vegetative phase are simple, while adult leaves are morphologically complex. The juvenile to adult transition is regulated by miR156, a microRNA that promotes juvenility by impeding the function of SPL transcription factors, which specify adult leaf traits. Both leaf derived sugars, as well as the Mediator Cyclin Dependent Kinase 8 (CDK8) module genes CENTER CITY (CCT)/MED12 and GRAND CENTRAL (GCT)/MED13, act upstream of miR156 to promote the juvenile to adult transition. However, it is not known whether sugar, CCT and GCT repress miR156 independently, as part of the same pathway, or in a cooperative manner. Here we show that sugar treatment can repress MIR156 expression in the absence of CCT or GCT. Both cct and the photosynthetic mutant chlorina1 (ch1) (which decreases sugar synthesis) exhibit extended juvenile development and increased MIR156A and MIR156C expression. Compared to ch1 and cct single mutants, the ch1 cct double mutant has a stronger effect on juvenile leaf traits, higher MIR156C levels, and a dramatic increase in MIR156A. Our results show that sugar and the CDK8 module are capable of regulating MIR156 independently, but suggest they normally act together in a synergistic manner. Copyright © 2017 Elsevier Inc. All rights reserved.

  5. ECONOMIC DEVELOPMENT VERSUS SUSTAINABLE DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Liliana Scutaru

    2013-09-01

    Full Text Available The paper put in antithesis, theoretically, two models of development and evolution of mankind, namely, economic development based on consumption of the exhaustible resources and pollution and on the other hand the development based on the concepts of sustainable development, involving a new mentality on human life and environment. Economic development includes economic growth, quantified in particular through the GDP, aspect that leads to a reduced analysis taking into account a limited number of variables such as household income, employment labour, consumption of goods and services, etc.. Perpetuation of this model has led, over time, to the company's inability to solve the problems facing mankind today and serious discrepancies regarding current levels of human development. This type of model does not take into account variables such as unemployment, poverty, education, health, environmental pollution, population migration, urban overcrowding, social inclusion etc. At the opposite side of this type of development, which proves to be beyond the crowd problems currently facing humanity, is a new alternative model, that of sustainable development, which provides an integrated view of all these variables and hence the chance of the human society to a new level of evolution. The sustainable development model of mankind put, among others, the zero growth issue or even sustained decrease for some countries. This model requires also reducing resource consumption and increase sustainability of assets created. It also offers practical solutions to many current problems of mankind, among which we can mention providing food for a growing world population and producing clean alternative energy.

  6. Developing biobanks in developing countrie

    Directory of Open Access Journals (Sweden)

    Igor Rudan

    2014-08-01

    Full Text Available We call for the development of human biobanks in developing countries and describe several examples from low income countries which are already building their own biobanks. Developing human biobanks in developing countries requires strengthening of the research capacity to use the new technologies, as well as a shift in research investment priorities in order to reduce the inequity in international research that currently exists. A responsible approach from low-income countries to ethical issues will be another pre-requisite to the success of the ‘hypothesis-free’ research that will target the needs of the world’s poor.

  7. Powerstick development

    Energy Technology Data Exchange (ETDEWEB)

    Borshchevsky, A.; Chmielewski, A.; Chen-Kuo, H. [California Inst. of Tech., Pasadena, CA (United States). Jet Propulsion Lab.; Bass, J. [Hi-Z Technology, Inc., San Diego, CA (United States); Bugby, D. [Swales and Associates, Inc., Beltsville, MD (United States); Pustovalov, A.; Gusev, V. [BIAPOS, Moscow (Russian Federation)

    1997-12-31

    A device called a Powerstick is being developed to satisfy the requirements of several potential solar system exploration missions. The Powerstick is a small power source consisting of three major components: a space qualified heat source (RHU), a thermopile (thermoelectric converter) and a set of rechargeable batteries. The Powerstick merges several devices developed earlier by the space power programs. The RHU was developed by DOE for the Galileo and Ulysses missions, the thermopile is a combination of the early RTG technology and pace maker technology with new packaging techniques, and a lithium-ion rechargeable battery is currently being developed for space applications. NASA has recently awarded a Small Business Technology Transfer (STTR) contract to Hi-Z Technology, Inc. of San Diego to manufacture a miniaturized thermopile and provide a preliminary design of the Powerstick. JPL`s Solar System Exploration Program funded Powerstick prototype design and fabrication contract with Swales and Associates, Inc. The Swales unit and the Hi-Z thermopile will be integrated at JPL. This integrated prototype with the thermopile, rechargeable batteries and electrical RHU simulator will be tested at JPL. At the same time JPL is pursuing a ruggedized Powerstick development with the Russian company BIAPOS. BIAPOS is to independently design, build and deliver to JPL for testing their own version of the Powerstick. According to the technology development road map for small space sources the American and Russian efforts will lead to the development of an engineering and qualification Powerstick unit by the end of the century.

  8. Untenable development

    Energy Technology Data Exchange (ETDEWEB)

    Coimbra, Guilhermina Lavoz [Universidade Federal Rural do Rio de Janeiro, RJ (Brazil)

    1995-12-31

    The author analyses the energy - the role of law and environmental rights for sustainable development - from a critical point of view that is in accordance with internationally accepted jurisprudence. (author). 12 refs.

  9. Brain Development

    Science.gov (United States)

    ... 4301 About Us Our Work Our Team Media Careers Contact Us Reprints & Permissions Explore Our Topics Early Development & Well-Being Early Learning Parenting Policy & Advocacy Resources & Services Annual Conference 2017 - Registration ...

  10. Preschooler development

    Science.gov (United States)

    ... Stanton BF, St. Geme JW, Schor NF, eds. Nelson Textbook of Pediatrics . 20th ed. Philadelphia, PA: Elsevier; 2016:chap 12. ... Normal development. In: Marcdante KJ, Kliegman RM, eds. Nelson Essentials ... . 7th ed. Philadelphia, PA: Elsevier Saunders; 2015:chap ...

  11. Personality Development

    Directory of Open Access Journals (Sweden)

    Osman Ozdemir

    2012-12-01

    Full Text Available Personality is the integration of characteristics acquired or brought by birth which separate the individual from others. Personality involves aspects of the individual's mental, emotional, social, and physical features in continuum. Several theories were suggested to explain developmental processes of personality. Each theory concentrates on one feature of human development as the focal point, then integrates with other areas of development in general. Most theories assume that childhood, especially up to 5-6 years, has essential influence on development of personality. The interaction between genetic and environmental factors reveals a unique personality along growth and developmental process. It could be said that individual who does not have any conflict between his/her basic needs and society's, has well-developed and psychologically healthy personality.

  12. Fetal development

    Science.gov (United States)

    ... begins to move and stretch. The liver and pancreas produce secretions. Your little one now makes sucking ... The baby is more active with increased muscle development. The mother can feel the baby moving. Baby's ...

  13. Developing markets?

    DEFF Research Database (Denmark)

    Figueiredo, Bernardo; Chelekis, Jessica; DeBerry-Spence, Benet

    2015-01-01

    , and social inequalities. We suggest that these issues are better understooda nd addressed when examined via grounded investigations of the role of markets in shaping the management of resources, consumer agency, power inequalities and ethics. The use of markets as units of analysis may lead to further cross......Situated at the intersection of markets and development, this commentary aims to promote a cross-fertilization of macromarketing and transformative consumer research (TCR) that directs attention to the sociocultural context and situational embeddedness of consumer experience and wellbeing, while...... acknowledging complex, systemic interdependencies between markets, marketing, and society. Based on a critical review of the meaning of development and an interrogation of various developmental discourses, the authors develop a conceptual framework that brings together issues of development, wellbeing...

  14. Toddler Development

    Science.gov (United States)

    ... watch your toddler learn new skills. The normal development of children aged 1-3 includes several areas: Gross motor - walking, running, climbing Fine motor - feeding themselves, drawing Sensory - seeing, hearing, tasting, touching, and smelling Language - saying ...

  15. Organisational development.

    Science.gov (United States)

    2017-03-30

    The aim of the NHS Improvement national leadership and improvement strategy is to encourage leaders at all levels to develop leadership skills in their staff and themselves. It focuses on fostering compassionate, collaborative and inclusive leadership.

  16. Recent Developments

    CERN Multimedia

    Lankford, A J

    Progress has proceeded rapidly on many parallel developments throughout the Trigger, Data Acquisition, and Detector Controls Project. As design has proceeded on the component TDAQ/DCS systems and subsystems, significant integration tests have been performed. Late last year and early this year, high level trigger and data acquisition developments were brought together in what we called the Phase 1 integrated prototype. During the same period, work was started on integrating the Detector Control System (DCS) with the Online Software that will be used to control, configure, and monitor ATLAS. In addition, integration tests between components of the Level 1 Trigger (LVL1) and Dataflow systems have been performed. The Phase 1 integrated prototype involved integrating the prototype level 2 trigger system (LVL2) developed by the LVL2 Pilot Project with the prototype data acquisition system and one of the Event Filter prototypes developed by the DAQ/EF -1 Prototype project. The integrated prototype included a VME Re...

  17. Infrastructure Development

    DEFF Research Database (Denmark)

    Williams, Idongesit

    2012-01-01

    It is the quest of every government to achieve universal Access and service of telecommunication services and ICTs. Unfortunately due to the high cost of deploying infrastructure in rural areas of developing countries due to non-significant or no economic activity, this dream of achieving Universal...... access and service of telecommunications/ICTs have been stalled. This paper throws light on a possible Public Private Partnership framework as a development path that will enable affordable network technologies to be deployed in rural areas at a cost that will translate to what the rural dweller...

  18. Infrastructure Development

    DEFF Research Database (Denmark)

    Williams, Idongesit

    2012-01-01

    It is the quest of every government to achieve universal Access and service of telecommunication services and ICTs. Unfortunately due to the high cost of deploying infrastructure in rural areas of developing countries due to non-significant or no economic activity, this dream of achieving Universal...... access and service of telecommunications/ICTs have been stalled. This paper throws light on a possible Public Private Partnership framework as a development path that will enable affordable network technologies to be deployed in rural areas at a cost that will translate to what the rural dweller...

  19. Dairy development

    NARCIS (Netherlands)

    Leegwater, P.; Hoorweg, J.C.

    2000-01-01

    The growth of the dairy sector as it has occurred in Kilifi and Malindi Districts is one of the few examples of successful agricultural development in the coastal region in the past decades. Between 1985 and 1997 dairy cattle have more than doubled in number. Three livestock systems are described:

  20. CAREER DEVELOPMENT

    Science.gov (United States)

    The Baltimore Summit Project on Career Development/PERFORMS Enhancement/360 Evaluations for All has made some progress. We have identified the fact that we cannot change the current Pass/Fail PERFORMS system to a tiered system. The current pass/fail system does not have a mechani...

  1. Spacelab's development

    Science.gov (United States)

    Bignier, M.

    1983-11-01

    Significant events in the international cooperation between ESA members and NASA in the development of Spacelab are outlined. The agreement to develop Spacelab in Europe was formalized in a MOU between NASA and ESRO in 1972, and was followed by configuration studies in both Europe and the U.S. It was decided in 1973 that ESA would build the hardware and turn it over to NASA, which would fly Spacelab on the Shuttle and buy a second Spacelab manned module. Once delivered, all responsibility for Spacelab would be transferred to NASA. A total of 10 European countries participated in the design, construction, and testing, performed by a project team of 100 engineers and 40 industrial companies. Design reviews were performed until 1981, in concert with hardware development of both Spacelab and pallets. The Eureca free-flying platform is being developed as a follow-on project, and studies are being conducted for activities in the future, such as participation in a space station.

  2. Developing Friendships:

    DEFF Research Database (Denmark)

    Hansen, Annette Skovsted

    2005-01-01

    reparations and - to a lesser degree - ODA as repentance for war crimes. Officials and other invlved parties often coded their interventions of development projects in language of friendship, whereby they expressed a Japanese desire to change the image of Japan from enemy to friend. In the wake of WWII...

  3. Developing ADHD

    Science.gov (United States)

    Taylor, Eric

    2009-01-01

    Over the past 50 years the concept of attention deficit/hyperactivity disorder (ADHD) has developed from the notion of a specific form of brain dysfunction to that of a heterogeneous set of related behaviours. The great advances in genetics, neuroimaging and neuropsychiatry have made it one of the best understood forms of complex mental…

  4. Leadership Development

    OpenAIRE

    Oana Simona Hudea

    2014-01-01

    This paper aims at rendering the main characteristics distinguishing leaders from common individuals, as well as from managers, while identifying the progressive steps and the key elements needed for leader development. Learning how to lead oneself is a prerequisite for leading others, but without continuous training, coaching or mentoring, and above all, without effective experience, individuals will never get to become real leaders.

  5. Professional Development.

    Science.gov (United States)

    Swanson, Gordon I.; Jervis, Robert

    Resulting in part from a project designed to identify and describe comprehensive programs of excellence in career education, this booklet is the eighth in a series describing current, successful career education practices. A successful career education program is dependent upon professional development. Based on this premise, the monograph: (1)…

  6. Marker development

    Energy Technology Data Exchange (ETDEWEB)

    Adams, M.R.

    1987-05-01

    This report is to discuss the marker development for radioactive waste disposal sites. The markers must be designed to last 10,000 years, and place no undue burdens on the future generations. Barriers cannot be constructed that preclude human intrusion. Design specifications for surface markers will be discussed, also marker pictograms will also be covered.

  7. Contraceptive Development.

    Science.gov (United States)

    Troen, Philip; And Others

    This report provides an overview of research activities and needs in the area of contraceptive development. In a review of the present state, discussions are offered on the effectiveness and drawbacks of oral contraceptives, intrauterine devices, barrier methods, natural family planning, and sterilization. Methods of contraception that are in the…

  8. In Development

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    At the end of 2005, Ethiopian Minister of Foreign Affairs Seyoum Mesfin visited China at the invitation of his counterpart Li Zhaoxing. While in Beijing, he met with Chinese ministers and "many, many" enterprises interested in investing in Ethiopia. During an interview with Beijing Review reporter Ni Yanshuo, Mesfin shared his thoughts on the development of Africa and Ethiopia.

  9. DEVELOPING WORDSMITH

    Directory of Open Access Journals (Sweden)

    Mike Scott

    2008-06-01

    Full Text Available WordSmith Tools, since its launch in 1996, has had a rather unusual history and the aim of this paper is to record some of the chief influences on its development. The paper thus presents and discusses the history of WordSmith Tools and its predecessors going back to the early 1980s when processors were much slower, memory very limited and disk space expensive. It is structured around the discussion of certain key issues, principles and themes. These include: “on the fly” processing, corpus flexibility, language independence, user control aspects, the unpredictability of design needs, a move towards remote processes, modular construction principles, software production management, pattern-seeking and the development of new corpus linguistic terms.

  10. Leadership Development

    Directory of Open Access Journals (Sweden)

    Oana Simona Hudea

    2014-12-01

    Full Text Available This paper aims at rendering the main characteristics distinguishing leaders from common individuals, as well as from managers, while identifying the progressive steps and the key elements needed for leader development. Learning how to lead oneself is a prerequisite for leading others, but without continuous training, coaching or mentoring, and above all, without effective experience, individuals will never get to become real leaders.

  11. Polarization developments

    Energy Technology Data Exchange (ETDEWEB)

    Prescott, C.Y.

    1993-07-01

    Recent developments in laser-driven photoemission sources of polarized electrons have made prospects for highly polarized electron beams in a future linear collider very promising. This talk discusses the experiences with the SLC polarized electron source, the recent progress with research into gallium arsenide and strained gallium arsenide as a photocathode material, and the suitability of these cathode materials for a future linear collider based on the parameters of the several linear collider designs that exist.

  12. LYMPHATIC DEVELOPMENT

    OpenAIRE

    Butler, Matthew G; Isogai, Sumio; Weinstein, Brant M.

    2009-01-01

    The lymphatic system is essential for fluid homeostasis, immune responses, and fat absorption, and is involved in many pathological processes, including tumor metastasis and lymphedema. Despite its importance, progress in understanding the origins and early development of this system has been hampered by lack of defining molecular markers and difficulties in observing lymphatic cells in vivo and performing genetic and experimental manipulation of the lymphatic system. Recent identification of...

  13. Yardang Development

    Science.gov (United States)

    2004-01-01

    [figure removed for brevity, see original site] Released 16 July 2004 The atmosphere of Mars is a dynamic system. Water-ice clouds, fog, and hazes can make imaging the surface from space difficult. Dust storms can grow from local disturbances to global sizes, through which imaging is impossible. Seasonal temperature changes are the usual drivers in cloud and dust storm development and growth. Eons of atmospheric dust storm activity has left its mark on the surface of Mars. Dust carried aloft by the wind has settled out on every available surface; sand dunes have been created and moved by centuries of wind; and the effect of continual sand-blasting has modified many regions of Mars, creating yardangs and other unusual surface forms. This image illustrates different amounts of yardang development on the large deposit found on the floor of Nicholson Crater. Note the formation of the ridge/trough shape at the bottom part of the main deposit. Image information: VIS instrument. Latitude 0.2, Longitude 195.3 East (164.7 West). 19 meter/pixel resolution. Note: this THEMIS visual image has not been radiometrically nor geometrically calibrated for this preliminary release. An empirical correction has been performed to remove instrumental effects. A linear shift has been applied in the cross-track and down-track direction to approximate spacecraft and planetary motion. Fully calibrated and geometrically projected images will be released through the Planetary Data System in accordance with Project policies at a later time. NASA's Jet Propulsion Laboratory manages the 2001 Mars Odyssey mission for NASA's Office of Space Science, Washington, D.C. The Thermal Emission Imaging System (THEMIS) was developed by Arizona State University, Tempe, in collaboration with Raytheon Santa Barbara Remote Sensing. The THEMIS investigation is led by Dr. Philip Christensen at Arizona State University. Lockheed Martin Astronautics, Denver, is the prime contractor for the Odyssey project, and

  14. Divine development

    DEFF Research Database (Denmark)

    Agarwala, Rina

    2015-01-01

    This article examines how Indian Americans’ religious organizations send not only financial remittances to India, but also social remittances that shape development ideologies. Comparing Indian-American Hindu and Muslim organizations, I find both groups draw from their socioeconomic experiences...... in India and use their position as elite immigrants in the United States to identify and empower their respective religious constituencies in India and overturn different social relations (not just religious practices). Hindu Americans draw from their majority status in India to overturn India's lower...

  15. Bone development

    DEFF Research Database (Denmark)

    Tatara, M.R.; Tygesen, Malin Plumhoff; Sawa-Wojtanowicz, B.

    2007-01-01

    The objective of this study was to determine the long-term effect of alpha-ketoglutarate (AKG) administration during early neonatal life on skeletal development and function, with emphasis on bone exposed to regular stress and used to serve for systemic changes monitoring, the rib. Shropshire ram...... the groups were recorded int erms of: (1) growth rate, (2) body weight at days 14, 28 and 130 of age or (3) final body weight. The weight and length of ribs were, however, significantly increased in the lambs given AKG for the first 14 days of neonatal life by 8.2% and 3.2%, respectively (P....01). Furthermore, AKG administration induced significantly higher bone mineral density of the cortical bone by 7.1% (P

  16. Biofilm development

    DEFF Research Database (Denmark)

    Tolker-Nielsen, Tim

    2015-01-01

    During the past decade we have gained much knowledge about the molecular mechanisms that are involved in initiation and termination of biofilm formation. In many bacteria, these processes appear to occur in response to specific environmental cues and result in, respectively, induction or terminat......During the past decade we have gained much knowledge about the molecular mechanisms that are involved in initiation and termination of biofilm formation. In many bacteria, these processes appear to occur in response to specific environmental cues and result in, respectively, induction...... or termination of biofilm matrix production via the second messenger molecule c-di-GMP. In between initiation and termination of biofilm formation we have defined specific biofilm stages, but the currently available evidence suggests that these transitions are mainly governed by adaptive responses......, and not by specific genetic programs. It appears that biofilm formation can occur through multiple pathways and that the spatial structure of the biofilms is species dependent as well as dependent on environmental conditions. Bacterial subpopulations, e.g., motile and nonmotile subpopulations, can develop...

  17. Investigation of anatomical anomalies in Hanford Site mule deer

    Energy Technology Data Exchange (ETDEWEB)

    Tiller, B.L.; Cadwell, L.L.; Poston, T.M. [and others

    1997-03-01

    Rocky Mountain mule deer (Odocoileus hemionus hemionus), common residents of the Hanford Site, are an important part of the shrub-steppe ecosystem as well as being valued for aesthetics and hunting. Because mule deer have been protected from hunting on the Site for 50 years, the herd has developed unique population characteristics, including a large number of old animals and males with either large or atypically developed antlers, in contrast to other herds in the semi-arid regions of the Northwest. Hanford Site mule deer have been studied since 1991 because of the herd`s unique nature and high degree of public interest. A special study of the mule deer herd was initiated in 1993 after observations were made of a relatively large number of male deer with atypical, velvet-covered antlers. This report specifically describes our analyses of adult male deer found on the Site with atypical antlers. The report includes estimates of population densities and composition; home ranges, habitat uses, and dietary habits; natural and human-induced causes of mortality; and the herd`s overall health and reproductive status.

  18. Effects of TGFbeta1 and extracts from Cervus korean TEMMINCK var. mantchuricus Swinhoe on acute and chronic arthritis in rats.

    Science.gov (United States)

    Kim, Kyung-Woon; Song, Kwon-Ho; Lee, Ji-Min; Kim, Kap-Sung; Kim, Sung-Il; Moon, Sung-Kwon; Kang, Bong-Seok; Kim, Dong-Soo; Chung, Kang-Hyun; Chang, Young-Chae; Kim, Cheorl-Ho

    2008-07-23

    To elucidate the pharmacological activities of deer antler acupuncture and TGF61538;1 on the acute and chronic phases of rheumatoid arthritis diseases. Polyarthritis rats were administered with TGF61538;1 and water extract of deer antler acupunture (DAA), prepared from the pilose antler of Cervus korean TEMMINCK var. mantchuricus Swinhoe. TGF61538; (0.1 to 2 61549;g/animal) and DAA (5-100 61549;g/kg animal) were initiated 1 day before an arthritogenic dose of streptococcal cell wall fragments to see the effects on the joint swelling and distortion during the acute phase and the chronic phase of the disease. Arthritic index suppression of rat arthritis model was examined by TGF61538; and DAA administrations. TGF61538;1 and DAA diminished the polyarthritis development in rats. TGF61538; and DAA eliminated the joint swelling and distortion observed during the acute phase and the chronic phase of the disease. The TGF61538; and DAA suppressed the arthritis progress when administration was begun after acute phase of arthritis. Consistent with the inhibition of inflammatory cell recruitment into the synovium, TGF61538;1 and DAA reversed the leukocytosis associated with the chronic phase of the arthritis, respectively.

  19. Sustainable Development: The Challenge for Community Development.

    Science.gov (United States)

    Gamble, Dorothy N.; Weil, Marie O.

    1997-01-01

    Five areas of inquiry shape the sustainable development movement: environmental movement, women's movement, overpopulation concerns, critique of development models, and new indicators of social progress. Community development workers are challenged to prepare local development projects within a sustainable development framework. (SK)

  20. Sustainable Development: The Challenge for Community Development.

    Science.gov (United States)

    Gamble, Dorothy N.; Weil, Marie O.

    1997-01-01

    Five areas of inquiry shape the sustainable development movement: environmental movement, women's movement, overpopulation concerns, critique of development models, and new indicators of social progress. Community development workers are challenged to prepare local development projects within a sustainable development framework. (SK)

  1. VAP Development: Initiation, Development, Evaluation, and Release

    Energy Technology Data Exchange (ETDEWEB)

    Jensen, M; Collis, Fast, J; Flynn, C; Mather, J; McFarlane, S; Monroe, J; Sivaraman, C; Xie, S

    2011-02-23

    This white paper provides a plan to formalize the evaluation of newly developed VAPs and a framework for the development of value-added products through four different stages: Initiation, Development, Evaluation, and Release.

  2. Development Research in/on Educational Development

    OpenAIRE

    Plomp, T

    2000-01-01

    In the practice of education, much design and development activities are taking place: curriculum development, instructional design, multimedia design, textbook development, etc. However, there is not much knowledge about how to design and develop, neither about criteria for the outcomes of design and development activities. Development research is a problem oriented, interdisciplinary research approach aimed at reducing uncertainty of design decisions, generating concrete recommendations for...

  3. 大小兴安岭驼鹿角型的变异%Variation of Moose Antler from Great and Little Xing'anling Mountain

    Institute of Scientific and Technical Information of China (English)

    白素英

    2005-01-01

    为比较大、小兴安岭驼鹿角型的差异,统计分析了二者自然脱落的干角1000余只,结果表明,除2杈和3杈角型基本一致外,4杈以上形状变化较大.主要表现在:大兴安岭所产驼鹿角的分杈数比小兴安岭所产驼鹿角分杈数多.大兴安岭所产驼鹿角分杈数可达9杈,而小兴安岭驼鹿角分杈数最多为6杈;大兴安岭驼鹿角4杈以上为掌状,属"掌型",而小兴安岭驼鹿角4杈以上绝大多数为"杈型";大小兴安岭驼鹿角各种分杈所占比例不同.大兴安岭驼鹿的4杈角最多,而小兴安岭驼鹿的3杈角最多;对于分杈数相同的驼鹿角,大兴安岭产驼鹿角的掌状面积、最大角长和重量都大于小兴安岭驼鹿角;而大兴安岭驼鹿角的角基直径却小于小兴安岭驼鹿角.

  4. Cultural Technique of Deer Antler Stem Cell in Vitro%鹿茸干细胞体外培养技术的研究

    Institute of Scientific and Technical Information of China (English)

    孙红梅; 邢秀梅; 丛波; 李春义; 杨福合

    2007-01-01

    利用消化酶消化法,用DMEM培养基对鹿茸干细胞进行了体外培养,分别从原代培养、传代、冻存、以及复苏等几个环节进行了试验.摸索鹿茸干细胞合适的体外培养条件,为鹿茸的各项相关研究打基础.结果表明,用透明质酸酶和胶原酶对组织样进行消化,然后用10%DMEM培养基进行培养细胞生长效果较好.适宜培养条件是37℃、5%CO2最大饱和湿度.

  5. SAFETY EVALUATION OF PREPARATION OF PILOSE ANTLER AND GINSENG IN TOXICOLOGY%鹿茸人参制剂的毒理学安全性评价

    Institute of Scientific and Technical Information of China (English)

    隋海霞; 高芃; 耿桂英; 刘海波; 汪会玲; 徐海滨

    2007-01-01

    [目的]了解鹿茸人参制剂的安全性.[方法]小鼠急性经口毒性试验,Ames试验,小鼠骨髓嗜多染红细胞微核试验,小鼠精子畸形试验,大鼠30 d喂养试验.[结果]该制剂急性经口毒性为无毒,在三项遗传毒性试验中均为阴性结果,在30 d喂养试验中也无异常发现.[结论]鹿茸人参制剂安全无毒.

  6. 气流粉碎机超微粉碎鹿茸的研究%Research on Ultrafine Smashing Antler by Jet Mill

    Institute of Scientific and Technical Information of China (English)

    杨静; 张争明; 李伯廷; 秦金山

    2012-01-01

      应用TC型流化床超音速气流粉碎机组对鹿茸进行超微粉碎,研究了气流粉碎机的工艺参数对超微粉碎鹿茸效果的影响;研究了分级机转速、进气压力、进料粒度对鹿茸超微粉碎的影响,同时还研究了不同加工方法干燥的鹿茸和不同部位的鹿茸等药材本身的物料性能对粉碎效果的影响。用激光粒度分析仪测定其微粉的粒度分布。在设备进气压力1畅0MPa ,分级机反转2400r/min ,进料粒度80目的操作参数下,能得到烘干鹿茸微粉的中位粒径为18畅09μm ,冻干鹿茸微粉的中位粒径为30畅6μm;烘干茸较冻干茸易粉碎,鹿茸部位不同粉碎的效果不同。运用TC型流化床超音速气流粉碎机组实现并优化了鹿茸的超微粉碎。

  7. Developed-developing country partnerships: Benefits to developed countries?

    Directory of Open Access Journals (Sweden)

    Syed Shamsuzzoha B

    2012-06-01

    Full Text Available Abstract Developing countries can generate effective solutions for today’s global health challenges. This paper reviews relevant literature to construct the case for international cooperation, and in particular, developed-developing country partnerships. Standard database and web-based searches were conducted for publications in English between 1990 and 2010. Studies containing full or partial data relating to international cooperation between developed and developing countries were retained for further analysis. Of 227 articles retained through initial screening, 65 were included in the final analysis. The results were two-fold: some articles pointed to intangible benefits accrued by developed country partners, but the majority of information pointed to developing country innovations that can potentially inform health systems in developed countries. This information spanned all six WHO health system components. Ten key health areas where developed countries have the most to learn from the developing world were identified and include, rural health service delivery; skills substitution; decentralisation of management; creative problem-solving; education in communicable disease control; innovation in mobile phone use; low technology simulation training; local product manufacture; health financing; and social entrepreneurship. While there are no guarantees that innovations from developing country experiences can effectively transfer to developed countries, combined developed-developing country learning processes can potentially generate effective solutions for global health systems. However, the global pool of knowledge in this area is virgin and further work needs to be undertaken to advance understanding of health innovation diffusion. Even more urgently, a standardized method for reporting partnership benefits is needed—this is perhaps the single most immediate need in planning for, and realizing, the full potential of international

  8. Developed-developing country partnerships: benefits to developed countries?

    Science.gov (United States)

    Syed, Shamsuzzoha B; Dadwal, Viva; Rutter, Paul; Storr, Julie; Hightower, Joyce D; Gooden, Rachel; Carlet, Jean; Bagheri Nejad, Sepideh; Kelley, Edward T; Donaldson, Liam; Pittet, Didier

    2012-06-18

    Developing countries can generate effective solutions for today's global health challenges. This paper reviews relevant literature to construct the case for international cooperation, and in particular, developed-developing country partnerships. Standard database and web-based searches were conducted for publications in English between 1990 and 2010. Studies containing full or partial data relating to international cooperation between developed and developing countries were retained for further analysis. Of 227 articles retained through initial screening, 65 were included in the final analysis. The results were two-fold: some articles pointed to intangible benefits accrued by developed country partners, but the majority of information pointed to developing country innovations that can potentially inform health systems in developed countries. This information spanned all six WHO health system components. Ten key health areas where developed countries have the most to learn from the developing world were identified and include, rural health service delivery; skills substitution; decentralisation of management; creative problem-solving; education in communicable disease control; innovation in mobile phone use; low technology simulation training; local product manufacture; health financing; and social entrepreneurship. While there are no guarantees that innovations from developing country experiences can effectively transfer to developed countries, combined developed-developing country learning processes can potentially generate effective solutions for global health systems. However, the global pool of knowledge in this area is virgin and further work needs to be undertaken to advance understanding of health innovation diffusion. Even more urgently, a standardized method for reporting partnership benefits is needed--this is perhaps the single most immediate need in planning for, and realizing, the full potential of international cooperation between developed and

  9. App Development Paradigms for Instructional Developers

    Science.gov (United States)

    Luterbach, Kenneth J.; Hubbell, Kenneth R.

    2015-01-01

    To create instructional apps for desktop, laptop and mobile devices, developers must select a development tool. Tool selection is critical and complicated by the large number and variety of app development tools. One important criterion to consider is the type of development environment, which may primarily be visual or symbolic. Those distinct…

  10. Entrepreneurial Intentions in Developing and Developed Countries

    Science.gov (United States)

    Iakovleva, Tatiana; Kolvereid, Lars; Stephan, Ute

    2011-01-01

    Purpose: This study proposes to use the Theory of Planned Behaviour to predict entrepreneurial intentions among students in five developing and nine developed countries. The purpose is to investigate whether entrepreneurial intention and its antecedents differ between developing and developed countries, and to test the theory in the two groups of…

  11. App Development Paradigms for Instructional Developers

    Science.gov (United States)

    Luterbach, Kenneth J.; Hubbell, Kenneth R.

    2015-01-01

    To create instructional apps for desktop, laptop and mobile devices, developers must select a development tool. Tool selection is critical and complicated by the large number and variety of app development tools. One important criterion to consider is the type of development environment, which may primarily be visual or symbolic. Those distinct…

  12. Entrepreneurial Intentions in Developing and Developed Countries

    Science.gov (United States)

    Iakovleva, Tatiana; Kolvereid, Lars; Stephan, Ute

    2011-01-01

    Purpose: This study proposes to use the Theory of Planned Behaviour to predict entrepreneurial intentions among students in five developing and nine developed countries. The purpose is to investigate whether entrepreneurial intention and its antecedents differ between developing and developed countries, and to test the theory in the two groups of…

  13. Sustainability for Development Programmes

    OpenAIRE

    Stephen F Moseley

    2011-01-01

    Stephen F. Moseley is president emeritus of the Academy for Educational Development, treasurer of the Society of International Development International Governing Council, and associate editor of Development.

  14. Drug Development Process

    Science.gov (United States)

    ... Device Approvals The Drug Development Process The Drug Development Process Share Tweet Linkedin Pin it More sharing ... Pin it Email Print Step 1 Discovery and Development Discovery and Development Research for a new drug ...

  15. Human Development Report 1991: Financing Human Development

    OpenAIRE

    United Nations Development Programme, UNDP

    1991-01-01

    Lack of political commitment rather than financial resources is often the real barrier to human development. This is the main conclusion of Human Development Report 1991 - the second in a series of annual reports on the subject.

  16. Developing New Academic Developers: Doing before Being?

    Science.gov (United States)

    Kensington-Miller, Barbara; Brailsford, Ian; Gossman, Peter

    2012-01-01

    A small group of new academic developers reflected on their induction into the profession and wondered if things could have been done differently. The researchers decided to question the directors of three tertiary academic development units about how they recruited new developers, what skills and competences they looked for and how they inducted…

  17. Clean development mechanism: Perspectives from developing countries

    Energy Technology Data Exchange (ETDEWEB)

    Sari, Agus P.; Meyers, Stephen

    1999-06-01

    This paper addresses the political acceptability and workability of CDM by and in developing countries. At COP-3 in Kyoto in 1997, the general position among developing countries changed from strong rejection of joint implementation to acceptance of CDM. The outgrowth of CDM from a proposal from Brazil to establish a Clean Development Fund gave developing countries a sense of ownership of the idea. More importantly, establishing support for sustainable development as a main goal for CDM overcame the resistance of many developing countries to accept a carbon trading mechanism. The official acceptance of CDM is not a guarantee of continued acceptance, however. Many developing countries expect CDM to facilitate a substantial transfer of technology and other resources to support economic growth. There is concern that Annex I countries may shift official development assistance into CDM in order to gain carbon credits, and that development priorities could suffer as a result. Some fear that private investments could be skewed toward projects that yield carbon credits. Developing country governments are wary regarding the strong role of the private sector envisioned for CDM. Increasing the awareness and capacity of the private sector in developing countries to initiate and implement CDM projects needs to be a high priority. While private sector partnerships will be the main vehicle for resource transfer in CDM, developing country governments want to play a strong role in overseeing and guiding the process so that it best serves their development goals. Most countries feel that establishment of criteria for sustainable development should be left to individual countries. A key issue is how CDM can best support the strengthening of local capacity to sustain and replicate projects that serve both climate change mitigation and sustainable development objectives.There is support among developing countries for commencing CDM as soon as possible. Since official commencement must

  18. METROPOLITAN DEVELOPMENT, PHASE IN THE URBAN DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    DINCĂ Dragoş Valentin

    2013-12-01

    Full Text Available Metropolitan development succeeds chronologically, as well as structurally urban development, this means a new phase in the urban system development through the extension beyond its initial boundaries. Along with the cities’ surrounding areas population growth, especially through emigration from the cities, but as well as through the attraction of population from other localities, the geographical and the administrative boundaries of the cities become inadequate for the definition of the urban agglomerations that emerge. This extension is generated as well by an ample endogenous process of local economic development that is forcing the association of several local communities around an urban center becoming a growth pole in order to develop its level of competitiveness. Metropolitan development represents thus an administrative and economical challenge regarding the management and the coordination of an increased palette of resources.

  19. Education for sustainable development

    Institute of Scientific and Technical Information of China (English)

    Natalia P.; Tarasova D.

    2002-01-01

    @@ Summary Education is a very important factor in human development.Human development does not start with the possession of goods,as this is one measure of development. It begins with people and their education. There are, of course, other human development resources that are of importance. However, without education all other resources remain as latent potentials to support human development.

  20. The Duration of Development

    NARCIS (Netherlands)

    J. Tinbergen (Jan)

    1995-01-01

    textabstractThe author considers the problem of the duration of development and its consequences for development assistance, in the developing as well as developed countries. Emphasis is given to the influence of development aid and it is argued that the time dimension has important policy implicati

  1. Practical web development

    CERN Document Server

    Wellens, Paul

    2015-01-01

    This book is perfect for beginners who want to get started and learn the web development basics, but also offers experienced developers a web development roadmap that will help them to extend their capabilities.

  2. Wordpress web application development

    CERN Document Server

    Ratnayake, Rakhitha Nimesh

    2015-01-01

    This book is intended for WordPress developers and designers who want to develop quality web applications within a limited time frame and for maximum profit. Prior knowledge of basic web development and design is assumed.

  3. FPG Child Development Institute

    Science.gov (United States)

    ... Development, Teaching, and Learning The Frank Porter Graham Child Development Institute will partner with Zero to Three to ... 25 September 21, 2017 More Frank Porter Graham Child Development Institute The University of North Carolina at Chapel ...

  4. Child Development & Behavior Topics

    Science.gov (United States)

    ... Your Child Topics Commentaries Featured Links Contact Us Child Development & Behavior Topics A B C D E F ... Seat Safety Carbon Monoxide Chewing Tobacco Child Care Child Development Milestones Child Development, What Do Grown-Ups Know ...

  5. Child Development Associate. Child Growth and Development.

    Science.gov (United States)

    Oscar Rose Junior Coll., Midwest City, OK.

    The purpose of this Child Development Associate (CDA) training module, one of a series of 18, is to help the CDA intern understand the factors and principles which affect the total growth and development of children. Early sections of the module stipulate the module's competency-based objectives, define terms, and suggest procedures by which…

  6. Development as modernity, modernity as development

    NARCIS (Netherlands)

    Lushaba, L.S.

    2006-01-01

    Albeit the divergences on the debate about development in Africa, it is indubitable that the continent remains underdeveloped after five decades of development efforts. To understand this impasse, it is necessary to trace Africa's encounter with Europe to the period of early modernity. This paper

  7. SUSTAINABLE DEVELOPMENT THROUGH ECO-ECONOMIC DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Vergina CHIRITESCU

    2013-12-01

    Full Text Available The issue of the relationship between humankind and the environment became scientific and economic concerns of the international community since the first UN Conference on the Human Environment (Stockholm, 1972 and resulted in the work of the World Commission on Environment and Development, established in 1985. Report of the Commission presented in 1987 by GH Brundtland, entitled "Our Common Future" provided the first universally accepted definition of sustainable development as "development that meets the needs of the present generation without compromising the opportunities of future generations to meet their own needs". Brundtland Report, 1987, was reaffirmed by the United Nations Conference on Environment and Development / Earth Summit held in Rio de Janeiro - Brazil, 1992 which established the principles of Agenda 21, which was intended to be a guide implementation of sustainable development for the 21st century, a development that was required to be applied at national, regional and local level. [1] In the context of developing new eco-economic system adopted a number of international conventions that establish detailed obligations of the States and strict implementation deadlines climate change, biodiversity conservation, protection of forests and wetlands, limiting the use of certain chemicals, access information on the state of the environment and other international legal space outlining the practical application of the principles of sustainable economic development in ecological conditions.

  8. Curriculum Development: Teacher Involvement in Curriculum Development

    Science.gov (United States)

    Alsubaie, Merfat Ayesh

    2016-01-01

    In order for curriculum development to be effective and schools to be successful, teachers must be involved in the development process. An effective curriculum should reflect the philosophy, goals, objectives, learning experiences, instructional resources, and assessments that comprise a specific educational program ("Guide to curriculum…

  9. Open development networked innovations in international development

    CERN Document Server

    Reilly, Katherine M A

    2014-01-01

    The emergence of open networked models made possible by digital technology has the potential to transform international development. Open network structures allow people to come together to share information, organize, and collaborate. Open development harnesses this power, to create new organizational forms and improve people's lives; it is not only an agenda for research and practice but also a statement about how to approach international development. In this volume, experts explore a variety of applications of openness, addressing challenges as well as opportunities. Open development requires new theoretical tools that focus on real world problems, consider a variety of solutions, and recognize the complexity of local contexts. After exploring the new theoretical terrain, the book describes a range of cases in which open models address such specific development issues as biotechnology research, improving education, and access to scholarly publications. Contributors then examine tensions between open model...

  10. CDBG Economic Development Activity

    Data.gov (United States)

    Department of Housing and Urban Development — CDBG activity related to economic development, including commercial or industrial rehab, commercial or industrial land acquisition, commercial or industrial...

  11. Vehicle Development Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Supports the development of prototype deployment platform vehicles for offboard countermeasure systems.DESCRIPTION: The Vehicle Development Laboratory is...

  12. Vehicle Development Laboratory

    Data.gov (United States)

    Federal Laboratory Consortium — FUNCTION: Supports the development of prototype deployment platform vehicles for offboard countermeasure systems. DESCRIPTION: The Vehicle Development Laboratory is...

  13. Geothermal development opportunities in developing countries

    Energy Technology Data Exchange (ETDEWEB)

    Kenkeremath, D.C.

    1989-11-16

    This report is the proceedings of the Seminar on geothermal development opportunities in developing countries, sponsored by the Geothermal Division of the US Department of Energy and presented by the National Geothermal Association. The overall objectives of the seminar are: (1) Provide sufficient information to the attendees to encourage their interest in undertaking more geothermal projects within selected developing countries, and (2) Demonstrate the technological leadership of US technology and the depth of US industry experience and capabilities to best perform on these projects.

  14. Tibet under Unstoppable Development

    Institute of Scientific and Technical Information of China (English)

    SANTIAGO CASTILLO

    2007-01-01

    @@ The Tibetan people, who used to live a hard life, have now merged into China's economic development and look at development as the best way to raise their standard of living. They have left behind the era of the Dalai Lama's development-hampering feudal serfdom.In the past, Tibet's development seen today was almost unthinkable.

  15. Sencha Architect app development

    CERN Document Server

    Groner, Loiane

    2013-01-01

    A standard tutorial-based approach for using Sencha Architect to develop applications in Ext JS and Sencha Touch.Sencha Architect App Development is for Ext JS and Sencha Touch developers that are looking to improve their productivity by using Sencha Architect for app development. Basic knowledge of Ext JS and Sencha Touch is required.

  16. LGBT Career Development

    Science.gov (United States)

    Gedro, Julie

    2007-01-01

    In this paper, I would like to open a conversation with my HRD colleagues about the issues related to Lesbian, Gay, Bisexual and Transgender (LGBT) career development. This paper provides some insights about LGBT career development, analyzing the factors that distinguish LGBT career development from heterosexual career development.

  17. Agile Software Development

    Science.gov (United States)

    Biju, Soly Mathew

    2008-01-01

    Many software development firms are now adopting the agile software development method. This method involves the customer at every level of software development, thus reducing the impact of change in the requirement at a later stage. In this article, the principles of the agile method for software development are explored and there is a focus on…

  18. Agile Software Development

    Science.gov (United States)

    Biju, Soly Mathew

    2008-01-01

    Many software development firms are now adopting the agile software development method. This method involves the customer at every level of software development, thus reducing the impact of change in the requirement at a later stage. In this article, the principles of the agile method for software development are explored and there is a focus on…

  19. Innovation in Product Development

    DEFF Research Database (Denmark)

    McAloone, Tim C.; Restrepo-Giraldo, John Dairo

    2005-01-01

    The course on Innovation in Product Development attempts to identify and understand the nature of innovation and product development and their important factors. The course takes both a theoretical and a practical approach and employs a mix of lectures, project work and group discussion. Format...... insight. Course content The following aspects of innovation in product development are considered: - Humans and products - Needs and products - Product life - Teams creating products - Products creating business - Product development models - Organising product development - Product development tools...... - The future of product development....

  20. Innovation in Product Development

    DEFF Research Database (Denmark)

    McAloone, Tim C.; Restrepo-Giraldo, John Dairo

    2005-01-01

    insight. Course content The following aspects of innovation in product development are considered: - Humans and products - Needs and products - Product life - Teams creating products - Products creating business - Product development models - Organising product development - Product development tools......The course on Innovation in Product Development attempts to identify and understand the nature of innovation and product development and their important factors. The course takes both a theoretical and a practical approach and employs a mix of lectures, project work and group discussion. Format...... - The future of product development....

  1. Drug discovery and developments in developing countries ...

    African Journals Online (AJOL)

    Development, the pharmaceutical industry has a strong incentive to ... per head on all health programmes whereas it is less than $6 in ... is loans and grants from donor countries and almost ... production capacity through technology transfer so.

  2. Rural development policy and food industry development

    DEFF Research Database (Denmark)

    Baker, Derek; Abildtrup, Jens; Hedetoft, Anders

    2007-01-01

    Food industry firms in remote areas face a set of constraints, which have motivated the form and function of assistance instruments under various regional and rural development programmes. Recent food industry developments present new challenges to these firms, for which available assistance may...... be less appropriate. This paper employs telephone interviews and workshop discussions with firms in isolated locations to investigate their satisfaction with assistance programmes, their ability to innovate (through product introductions) and respond to challenges in the food industry (the emergence...

  3. INCUBATORS IN DEVELOPING COUNTRIES: DEVELOPMENT PERSPECTIVES

    Directory of Open Access Journals (Sweden)

    Miladin Stefanovic

    2008-06-01

    Full Text Available Business incubators aim to maximize the chances of success of start - up companies by creating a supportive environment. Typically, this involves offering management assistance, mentoring, access to financing, flexible and low - cost leases, office services, etc. There is large number of business incubators in the world. In this paper issues concerned status, development and overview of existing practice in the world will be presented as well as general issues and perspectives for developing countries.

  4. Jordan Adjusted Human Development

    OpenAIRE

    Ababsa, Myriam

    2014-01-01

    Jordan Human Development Index (HDI) and Adjusted Human Development Index (IHDI) In 1990, the United Nations Development Programme designed a Human Development Index composed of life expectancy at birth, level of education and gross domestic product (GDP) per capita. In 2011, the UNDP ranked Jordan 95th out of 187 countries with a human development index of 0.698, up from 0.591 in 1990, making it the leading medium-range country for human development (fig. VIII.1). In 2010, the inequality adj...

  5. Teacher Professional Development

    Directory of Open Access Journals (Sweden)

    Nareerat Rakwichitkul

    2017-06-01

    Full Text Available Teacher professional development are the teachers’ learning process throughout their career stages to ensure that teachers have knowledge, skills and needed competencies for teaching among rapid changes in social, economic and technology which have the impact on learning and teaching. This article deals with the topics of the framework for teaching, teacher career stages and teacher professional development. The research findings related to teacher professional development, teacher professional development activities, suggestions for planning the professional development. Those research findings can be applied and implemented by the school principals, educational supervisors and other professional developers.

  6. Hanford Site Development Plan

    Energy Technology Data Exchange (ETDEWEB)

    Rinne, C.A.; Curry, R.H.; Hagan, J.W.; Seiler, S.W.; Sommer, D.J. (Westinghouse Hanford Co., Richland, WA (USA)); Yancey, E.F. (Pacific Northwest Lab., Richland, WA (USA))

    1990-01-01

    The Hanford Site Development Plan (Site Development Plan) is intended to guide the short- and long-range development and use of the Hanford Site. All acquisition, development, and permanent facility use at the Hanford Site will conform to the approved plan. The Site Development Plan also serves as the base document for all subsequent studies that involve use of facilities at the Site. This revision is an update of a previous plan. The executive summary presents the highlights of the five major topics covered in the Site Development Plan: general site information, existing conditions, planning analysis, Master Plan, and Five-Year Plan. 56 refs., 67 figs., 31 tabs.

  7. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Kathryn Baskin

    2004-10-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  8. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Kathryn Baskin

    2004-07-28

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  9. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Kathryn Baskin

    2005-01-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  10. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Kathryn Baskin

    2004-07-28

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  11. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Kathryn Baskin

    2005-04-30

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts. In addition to analysis of domestic policies and programs, this project will include the development of a U.S.-Brazil Biodiesel Pilot Project. The purpose of this effort is to promote and facilitate the commercialization of biodiesel and bioenergy production and demand in Brazil.

  12. Rural development policy and food industry development

    DEFF Research Database (Denmark)

    Baker, Derek; Abildtrup, Jens; Hedetoft, Anders

    2007-01-01

    be less appropriate. This paper employs telephone interviews and workshop discussions with firms in isolated locations to investigate their satisfaction with assistance programmes, their ability to innovate (through product introductions) and respond to challenges in the food industry (the emergence......Food industry firms in remote areas face a set of constraints, which have motivated the form and function of assistance instruments under various regional and rural development programmes. Recent food industry developments present new challenges to these firms, for which available assistance may...

  13. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Kathryn Baskin

    2004-04-30

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts.

  14. DEVELOPING STATE POLICIES SUPPORTIVE OF BIOENERGY DEVELOPMENT

    Energy Technology Data Exchange (ETDEWEB)

    Kathryn Baskin

    2003-10-31

    Working within the context of the Southern States Biobased Alliance (SSBA) and with officials in each state, the Southern States Energy Board (SSEB) is identifying bioenergy-related policies and programs within each state to determine their impact on the development, deployment or use of bioenergy. In addition, SSEB will determine which policies have impacted industry's efforts to develop, deploy or use biobased technologies or products. As a result, SSEB will work with the Southern States Biobased Alliance to determine how policy changes might address any negative impacts or enhance positive impacts.

  15. The Development of Voiding

    DEFF Research Database (Denmark)

    Olsen, Lars Henning

    2011-01-01

    The thesis addresses some new aspeccts in the development of voiding function from midgestation into early childhood.......The thesis addresses some new aspeccts in the development of voiding function from midgestation into early childhood....

  16. Odoo development essentials

    CERN Document Server

    Reis, Daniel

    2015-01-01

    This book is intended for developers who need to quickly become productive with Odoo. You are expected to have experience developing business applications, as well as an understanding of MVC application design and knowledge of the Python programming language.

  17. CHP Project Development

    Science.gov (United States)

    Access information and tools to support the CHP project development process, including identifying if your facility is a good fit for CHP, the steps involved with CHP project development, and policies and incentives supportive of CHP.

  18. Mobile systems development

    DEFF Research Database (Denmark)

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.

    2007-01-01

    Development of mobile software is Surrounded by much uncertainty. Immature software platforms on mobile clients, a highly competitive market calling for innovation, efficiency and effectiveness in the development life cycle, and lacking end-user adoption are just some of the realities facing...... development teams in the mobile software industry. By taking a process view on development of mobile systems we seek to explore the strengths and limitations of eXtreme Programming (XP) in the context of mobile software development. Following an experimental approach a mobile systems development project...... running for four months is conducted. Experiences from the project are used for analysis and discussion of the fit of XP in mobile systems development. First, requirements for mobile systems development projects are proposed. Second, these are analysed and compared to the prescribed principles suggested...

  19. Adolescent growth and development.

    Science.gov (United States)

    Chulani, Veenod L; Gordon, Lonna P

    2014-09-01

    Adolescence is a developmental stage defined by physical and psychosocial maturation. This article reviews normal pubertal development and the evaluation and management of adolescents with suspected pubertal abnormalities and provides an overview of adolescent psychosocial development.

  20. Development and Environment.

    Science.gov (United States)

    Dubhashi, P. R.

    1994-01-01

    Review of environmental issues in India concludes that educational institutions can contribute to sustainable development by promoting understanding of the ecosystem; assessing a community's natural wealth; developing strategies; and promoting participation in environmental preservation projects. (SK)

  1. Game development tool essentials

    CERN Document Server

    Berinstein, Paula; Ardolino, Alessandro; Franco, Simon; Herubel, Adrien; McCutchan, John; Nedelcu, Nicusor; Nitschke, Benjamin; Olmstead, Don; Robinet, Fabrice; Ronchi, Christian; Turkowski, Rita; Walter, Robert; Samour, Gustavo

    2014-01-01

    Offers game developers new techniques for streamlining the critical game tools pipeline. Inspires game developers to share their secrets and improve the productivity of the entire industry. Helps game industry practitioners compete in a hyper-competitive environment.

  2. Collaborative software development

    NARCIS (Netherlands)

    Jonge, M. de; Visser, E.; Visser, J.M.W.

    2001-01-01

    We present an approach to collaborative software development where obtaining components and contributing components across organizational boundaries are explicit phases in the development process. A lightweight generative infrastructure supports this approach with an online package base, and several

  3. Growth and Development

    Science.gov (United States)

    ... Feeding Your 1- to 2-Year-Old Growth & Development What should you expect as your child grows? ... Understanding Puberty Your Child's Changing Voice Your Child's Development: 1.5 Years (18 Months) Your Child's Growth ...

  4. Contingent Information Systems Development

    NARCIS (Netherlands)

    van Slooten, C.; Schoonhoven, Bram

    1996-01-01

    Situated approaches based on project contingencies are becoming more and more an important research topic for information systems development organizations. The Information Services Organization, which was investigated, has recognized that it should tune its systems development approaches to the

  5. The Developing Brain.

    Science.gov (United States)

    Schatz, Carla J.

    1992-01-01

    Discusses neural activity and stimulation crucial in fetal brain development and the formation of the mind. Focuses on activity-dependent remodeling related to development of the visual system and retinal activity. (MCO)

  6. Strategic port development

    DEFF Research Database (Denmark)

    Olesen, Peter Bjerg; Dukovska-Popovska, Iskra; Hvolby, Hans-Henrik

    2014-01-01

    developments. This paper examines a series of models from the port development literature and then proposes an approach for conceptualizing the strategic development of a port’s collaboration with local operators and the local hinterland based on connected development steps. The paper is based on a literature...... review relevant to international port development and a case study done in a Danish port as part of the main authors PhD project. The proposed model provides a strategic approach to control and improve the development of a port system and the connected hinterland. While the model is generic in its......While large global ports are recognised as playing a central role in many supply chains as logistic gateways, smaller regional ports have been more stagnant and have not reached the same level of development as the larger ports. The research literature in relation to port development is also...

  7. Your Child's Development: Newborn

    Science.gov (United States)

    ... Child Too Busy? Helping Your Child Adjust to Preschool School Lunches Kids and Food: 10 Tips for Parents Healthy Habits for TV, Video Games, and the Internet Your Child's Development: Newborn KidsHealth > For Parents > Your Child's Development: Newborn ...

  8. Toddler Growth and Development

    Science.gov (United States)

    ... time, his or her physical growth and motor development will slow, but you can expect to see ... Schedule of Well-Child Care Visits . ​​ Toddler Growth & Development Physical Skills Walks alone Pulls toys behind when ...

  9. Mobile systems development

    DEFF Research Database (Denmark)

    Pedersen, Ole; Kristiansen, Martin Lund; Kammersgaard, Marc N.

    2007-01-01

    Development of mobile software is Surrounded by much uncertainty. Immature software platforms on mobile clients, a highly competitive market calling for innovation, efficiency and effectiveness in the development life cycle, and lacking end-user adoption are just some of the realities facing...... development teams in the mobile software industry. By taking a process view on development of mobile systems we seek to explore the strengths and limitations of eXtreme Programming (XP) in the context of mobile software development. Following an experimental approach a mobile systems development project...... running for four months is conducted. Experiences from the project are used for analysis and discussion of the fit of XP in mobile systems development. First, requirements for mobile systems development projects are proposed. Second, these are analysed and compared to the prescribed principles suggested...

  10. Dance talent development

    OpenAIRE

    Chua, Joey

    2015-01-01

    This qualitative study examined the culture-specific forms of dance talent development. Due to the scant and uneven literature in the field of dance talent development, this study firstly aimed at exploring the various theories and research methodologies underpinning current dance talent development literature. The other aims were to better understand how various catalysts and processes enhanced dancers development at different stages and helped guide students in actualizing their potential....

  11. Turbine Development in China

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    In view of the development of the electric power industry in China,in this paper,the author expounds the development of turbine manufacturing industry in recent years and analyses the development trends of the industry in the future,involving domestic market demand,the adjustment of power sources' structure,independent research and development and innovation,product structural adjustment,product technical level,enterprise management and market service,etc.

  12. Turbine Development in China

    Institute of Scientific and Technical Information of China (English)

    Zheng Jianfu; Li Jialu

    2009-01-01

    @@ In view of the development of the electric power industry in China,in this paper,the author expounds the development of turbine manufacturing industry in recent years and analyses the development trends of the industry in the future,involving domestic market demand,the adjustment of power sources' structure,independent research and development and innovation,product structural adjustment,product technical level,enterprise management and market service,etc.

  13. Gammasphere software development

    Energy Technology Data Exchange (ETDEWEB)

    Piercey, R.B.

    1993-01-01

    Activities of the nuclear physics group are described. Progress was made in organizing the Gammasphere Software Working Group, establishing a nuclear computing facility, participating in software development at Lawrence Berkeley, developing a common data file format, and adapting the ORNL UPAK software to run at Gammasphere. A universal histogram object was developed that defines a file format and provides for an objective-oriented programming model. An automated liquid nitrogen fill system was developed for Gammasphere (110 Ge detectors comprise the sphere).

  14. Gammasphere software development

    Energy Technology Data Exchange (ETDEWEB)

    Piercey, R.B.

    1993-01-01

    Activities of the nuclear physics group are described. Progress was made in organizing the Gammasphere Software Working Group, establishing a nuclear computing facility, participating in software development at Lawrence Berkeley, developing a common data file format, and adapting the ORNL UPAK software to run at Gammasphere. A universal histogram object was developed that defines a file format and provides for an objective-oriented programming model. An automated liquid nitrogen fill system was developed for Gammasphere (110 Ge detectors comprise the sphere).

  15. Chance and Talent Development

    Science.gov (United States)

    Gagne, Francoys; Schader, Robin M.

    2006-01-01

    The role of chance in talent development appears in the gifted education literature and also in lay discussions of high ability. Nevertheless, chance as a factor in talent development is frequently misunderstood. This analysis scrutinizes some common beliefs and scholarly perspectives on the effects of chance in the development of high ability,…

  16. The Sustainable Development Model

    OpenAIRE

    2012-01-01

    Sustainable development concept approaches quality of life in complexity, as economic, social and environmental issues, promoting the idea of balance between economic development, social equity, efficient utilization and environment conservation.     An essential condition for achieving sustainable development is the right mix of macroeconomic policies coherent, consistent with resources to ensure sustainability of materials and energy used for growth.

  17. PHOTOGRAPHIC FILM DEVELOPER

    Science.gov (United States)

    Berry, F.G.

    1958-06-24

    S>An improved photographic developer is presented having very high energy development fine grain characteristics and a long shelf life. These characteristics are obtained by the use of aminoacetic acid in the developer, the other constituents of which are: sodium sulfite, hydroquinone, sodiunn borate, boric acid and potassium bromide, 1-phenyl-3-pyrazolidone.

  18. Third wave development expertise

    NARCIS (Netherlands)

    Byskov, Morten

    2017-01-01

    In this paper I offer a normative account of development expertise. Although extending expertise beyond the traditional development experts to include local stakeholders, this normative account aims to delimit legitimate forms of expertise. I label this normative view third wave development expertis

  19. Does Educational Development Matter?

    Science.gov (United States)

    Knapper, Christopher

    2016-01-01

    This essay provides reflections on the growth and influence of educational development, and the changes in approaches to teaching in universities. It also identifies some areas in which educational development and developers face challenges for the future, including educational technology, leadership and resistance to change.

  20. Marketing Human Resource Development.

    Science.gov (United States)

    Frank, Eric, Ed.

    1994-01-01

    Describes three human resource development activities: training, education, and development. Explains marketing from the practitioners's viewpoint in terms of customer orientation; external and internal marketing; and market analysis, research, strategy, and mix. Shows how to design, develop, and implement strategic marketing plans and identify…

  1. Ethics and development

    NARCIS (Netherlands)

    D.R. Gasper (Des)

    2012-01-01

    markdownabstractThe field of development ethics explores questions and debates concerning what is good development of societies and of the world, and good development for individual persons. Generations of experience suggest the inadequacy of the assumption that societal-, world- or personal- develo

  2. Ethics and Development

    NARCIS (Netherlands)

    D.R. Gasper (Des)

    2014-01-01

    markdownabstract__Intro__ The field of development ethics explores questions and debates concerning what is good development of societies and of the world, and good development for individual persons. Generations of experience suggest the inadequacy of the assumption that societal-, world- or pers

  3. Education for sustainable development

    DEFF Research Database (Denmark)

    Breiting, Søren

    2009-01-01

     An introduction to the idea of sustainable development (SD) and education for sustainable development (ESD) with reference to the international Decade for Education for Sustainable Development . The chapter includes a focus on conflicting interests between present and future generations related...

  4. Yemen : Workforce Development

    OpenAIRE

    World Bank

    2014-01-01

    Yemen, which belongs to the category of Least Developed Countries according to the OECD s Development Assistance Committee, has faced many challenges during the last two decades in its endeavor to achieve an acceptable level of economic development. To inform policy dialogue on these important issues, this report presents a comprehensive diagnostic of the country s WfD policies and institu...

  5. Anthropology and inclusive development

    NARCIS (Netherlands)

    Bakker, L.; Nooteboom, G.

    Although the term inclusive development is still rare in anthropological texts, it is a key element of anthropology’s relation to development. Concerns of in/exclusion, unequal power relations and (lack of) voice are central here. Anthropology’s encounter with development primarily focuses on a

  6. Marketing Human Resource Development.

    Science.gov (United States)

    Frank, Eric, Ed.

    1994-01-01

    Describes three human resource development activities: training, education, and development. Explains marketing from the practitioners's viewpoint in terms of customer orientation; external and internal marketing; and market analysis, research, strategy, and mix. Shows how to design, develop, and implement strategic marketing plans and identify…

  7. Mechanisms in Plant Development

    Energy Technology Data Exchange (ETDEWEB)

    Hake, Sarah [USDA ARS Plant Gene Expression Center

    2013-08-21

    This meeting has been held every other year for the past twenty-two years and is the only regularly held meeting focused specifically on plant development. Topics covered included: patterning in developing tissues; short and long distance signaling; differentiation of cell types; the role of epigenetics in development; evolution; growth.

  8. Interpreting sustainable development

    Institute of Scientific and Technical Information of China (English)

    1998-01-01

    Over the past decade, the term" sustainable development"has emerged as the principal concept in the development field. The concept emerged in the 1970s and was first promoted in the international environmental and development communities with the publication of the " world conservation strategy"(1980). It was popularized by the Brundtland report, " Our common future"(1987). The Brundtland Commission defined sustainable development as " development which meets the needs of the present, without compromising the sustainability of future generation to meet their own needs". The Earth Summit(1992) established "sustainable development" as the most important policy of the 21st century. Since then, the relationship between development and environment has been widely discussed and sustainabale development is now an important part of the vocabulary of environmental policy research and analysis. In this paper, we begin by tracing the evolution of the concept of sustainable development. Definitions of sustainable development in ecology, economics and sociology are then explored and discussed. This paper also examine the contribution that a broadly-based concept of sustainable development can make: as a goal, an attitude and as a guiding principle for integrating economic development and environmental protection.

  9. Harmony in Development

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    At the 2006 session of the China Development Forum, Wang Mengkui, Director of the Development Research Center of the State Council, a think tank of China's cabinet, analyzed the trends of China's policy in terms of scientific development and social harmony. His main ideas, presented in People's Daily Online, follow.

  10. Moral Development in Adolescence

    Science.gov (United States)

    Hart, Daniel; Carlo, Gustavo

    2005-01-01

    Themes in the papers in this special issue of the "JRA" on moral development are identified. We discuss the intersection of moral development research with policy concerns, the distinctive qualities of moral life in adolescence that warrant investigation, the multiple connotations of "moral", the methods typical of moral development research, and…

  11. Education for sustainable development

    DEFF Research Database (Denmark)

    Breiting, Søren

    2009-01-01

     An introduction to the idea of sustainable development (SD) and education for sustainable development (ESD) with reference to the international Decade for Education for Sustainable Development . The chapter includes a focus on conflicting interests between present and future generations related...

  12. Child Development and Neuroscience.

    Science.gov (United States)

    Nelson, Charles A.; Bloom, Floyd E.

    1997-01-01

    Two major advances in developmental brain sciences have implications for understanding development: (1) neuroimaging; and (2) molecular and cellular events that give rise to the developing brain and ways in which the brain is modified by experiences. Critical, new knowledge of behavioral development can be achieved by considering the…

  13. Does Educational Development Matter?

    Science.gov (United States)

    Knapper, Christopher

    2016-01-01

    This essay provides reflections on the growth and influence of educational development, and the changes in approaches to teaching in universities. It also identifies some areas in which educational development and developers face challenges for the future, including educational technology, leadership and resistance to change.

  14. Essays on Child Development in Developing Countries

    Science.gov (United States)

    Humpage, Sarah Davidson

    2013-01-01

    This dissertation presents the results of three field experiments implemented to evaluate the effectiveness of strategies to improve the health or education of children in developing countries. In Guatemala, community health workers at randomly selected clinics were given patient tracking lists to improve their ability to remind parents when their…

  15. Buying Into Development?

    DEFF Research Database (Denmark)

    Ponte, Stefano; Richey, Lisa Ann

    2014-01-01

    Consumers, partnering with corporations and celebrities, are forming new alliances in international development through what we call ‘Brand Aid’ initiatives. At a time of shifting relationships between public and private aid, commodities are sold as the means of achieving development for recipients...... studies of ‘Win One Give One’, toms shoes and Product (red). We argue that these not only use imaginaries of development to sell products to Northern consumers but also engage in the work of a ‘story factory’ – producing truths about international development and consumer engagement that make development...

  16. Competence development in UAS

    DEFF Research Database (Denmark)

    Thorslund, Jørgen; Brodersen, Anne Mygind

    2011-01-01

    As a University of Applied Science (UAS) University College Lillebaelt in Denmark is addressing education, knowledge production and professional development in perspective of life-long and life-wide learning. It is our basic assumption that that internal competence development ? individually...... and organizationally - among UAS educators should be based on same learning concepts as used in professional development to avoid parallelism. Do for yourself, what you preach for others. Second, competence development of faculty is a central element in transformation of our institutions from schools of higher...... education to universities of applied science (UAS). Competence development strategies should thus include objectives for the institutions ability to contribute to knowledge production....

  17. Environmental Control Subsystem Development

    Science.gov (United States)

    Laidlaw, Jacob; Zelik, Jonathan

    2017-01-01

    Kennedy Space Center's Launch Pad 39B, part of Launch Complex 39, is currently undergoing construction to prepare it for NASA's Space Launch System missions. The Environmental Control Subsystem, which provides the vehicle with an air or nitrogen gas environment, required development of its local and remote display screens. The remote displays, developed by NASA contractors and previous interns, were developed without complete functionality; the remote displays were revised, adding functionality to over 90 displays. For the local displays, multiple test procedures were developed to assess the functionality of the screens, as well as verify requirements. One local display screen was also developed.

  18. Leadership Development Activities

    Directory of Open Access Journals (Sweden)

    Malikeh Beheshtifar

    2012-07-01

    Full Text Available Nowadays, human resource development is considered as a developed concept in HR field. It is a process for helping personnel to conduct their duties better. Most organizations tend to leadership development as a separable subject and as areas of responsibility within organization. Whereas the leadership development plans have been unsuccessful. This article aim to draw attention to the fact that leadership development is crucial in organizations. A literature review was conducted by searching journal databases, textbooks, and relevant reports. A categorization of the evidence allowed informed discussions on the key themes surrounding leadership development activities. Leadership development is caused to employees' promotion and progress via nurture of new talents, stimulus in employees by persuade to do individual development, save time and cost, and increase customers' satisfaction by relations improvement. Accordingly, the development systems can cover a wide scope in organization. They are effective to career management, training and development, performance management, strategic human resource planning, recruitment and selection, and succession planning activities. Despite the need for further scientific and validated studies, organizations should be urged to devote sufficient resources and attention towards leadership development for promoting long-term survival and prosperity.

  19. RELATIVITY AND SUSTAINABLE DEVELOPMENT

    Institute of Scientific and Technical Information of China (English)

    YE Dai-fu

    2004-01-01

    From the realism of science, and taking the guide of EINSTEIN's Relativity as guide, this article called in question the present theory of the sustainable development by the rational thinking of philosophy and a close logic inference. It is found that there are many paradoxes to the theory. Through more deepening and meticulous inference, we arrived at philosophic language of science about the sustainable development. The sustainable development is "non-sustainable development", and the non-sustainable development is "the best sustainable development''. While carrying out philosophical principle thinking and repeating science demonstration for the sustainable development, this article got further confirmation that the existence of human being at the minimum environment cost may help them obtain motive power of the sustainable development. In fact, this foundation motive power exists in the flow of development in different organization levels, meanwhile it exists in strategy of intuition living of the ancient people. Only in relative lower environment cost to live can we get the support system of science for the sustainable development, and be able really to achieve the basic goal of the sustainable development.

  20. Site Development Planning Handbook

    Energy Technology Data Exchange (ETDEWEB)

    None

    1981-01-01

    The Handbook provides facility managers and site planners at DOE organizations responsible for planning site developments and facilities utilization a step-by-step planning checklist to ensure that planners at each site are focusing on Department-wide goals and objectives. It begins with a brief discussion of a site development-by-objectives program design to promote, recognize, and implement opportunities for improvements in site utilization through planning. Additional information is included on: assembling existing data, plans, programs, and procedures; establishing realistic objectives; identifying site problems, opportunities; and development needs; determining priorities among development needs; developing short and long-range plans; choosing the right development solutions and meeting minimum legal site restrictions; presenting the plan; implementing elements of the plan; monitoring and reporting plan status; and modifying development program plans. (MCW)

  1. Arenas of development

    DEFF Research Database (Denmark)

    Sørensen, Ole Henning; Jørgensen, Ulrik

    1999-01-01

    In this paper the notion 'development arena' is presented and discussed. The notion is suggested to function as a cognitive space for research. It seeks to catch and describe the relational, unstable and heterogeneous character of the development process. It should sensitize both researchers...... and managers towards processes of technology development that are poorly accounted for in economic and management theory. Thereby, we wish to contribute to critical discussions about the role of management and the directions it chooses for development of technologies and products. The elements...... and transformations involved in shaping and restructuring activities in a development arena are described and discussed based on a case study of the development of HDTV as the next generation television. It exemplifies different moments and aspects of technology development. A number of configurations of specific...

  2. Strategic port development

    DEFF Research Database (Denmark)

    Olesen, Peter Bjerg; Dukovska-Popovska, Iskra; Hvolby, Hans-Henrik

    2014-01-01

    While large global ports are recognised as playing a central role in many supply chains as logistic gateways, smaller regional ports have been more stagnant and have not reached the same level of development as the larger ports. The research literature in relation to port development is also...... developments. This paper examines a series of models from the port development literature and then proposes an approach for conceptualizing the strategic development of a port’s collaboration with local operators and the local hinterland based on connected development steps. The paper is based on a literature...... approach, the authors apply it to a Danish case study that illustrates its potential usage in determining port development....

  3. Evolution of Devonian carbonate-shelf margin, Nevada

    Science.gov (United States)

    Morrow, J.R.; Sandberg, C.A.

    2008-01-01

    The north-trending, 550-km-long Nevada segment of the Devonian carbonate-shelf margin, which fringed western North America, evidences the complex interaction of paleotectonics, eustasy, biotic changes, and bolide impact-related influences. Margin reconstruction is complicated by mid-Paleozoic to Paleogene compressional tectonics and younger extensional and strike-slip faulting. Reports published during the past three decades identify 12 important events that influenced development of shelf-margin settings; in chronological order, these are: (1) Early Devonian inheritance of Silurian stable shelf inargin, (2) formation of Early to early Middle 'Devonian shelf-margin basins, (3) propradation of later Middle Devonian shelf margin, (4) late Middle Devonian Taghanic ondap and continuing long-term Frasnian transgression, (5) initiation of latest Middle Devonian to early Frasnian proto-Antler orogenic forebulge, (6) mid-Frasnian Alamo Impact, (7) accelerated development of proto-Antler forebulge and backbulge Pilot basin, (8) global late Frasnian sentichatovae sea-level rise, (9) end-Frasnian sea-level fluctuations and ensuing mass extinction, (10) long-term Famennian regression and continept-wide erosion, (11) late Famennian emergence: of Ahtler orogenic highlands, and (12) end-Devonian eustatic sea-level fall. Although of considerable value for understanding facies relationships and geometries, existing standard carbonate platform-margin models developed for passive settings else-where do not adequately describe the diverse depositional and, structural settings along the Nevada Devonian platform margin. Recent structural and geochemical studies suggest that the Early to Middle Devonian-shelf-margin basins may have been fault-bound and controlled by inherited Precambrian structure. Subsequently, the migrating latest Middle to Late Devonian Antler orogenic forebulge exerted a dominant control on shelf-margin position, morphology, and sedimentation. ??Geological Society of

  4. Development. The decade of the developing brain.

    Science.gov (United States)

    Jessell, T M; Sanes, J R

    2000-10-01

    Our understanding of neural development has advanced dramatically over the past decade. Significant insights have now been obtained into seven fundamental developmental processes: first, induction of the neural plate; second, regionalization of the neural tube along the dorsoventral and anteroposterior axes; third, generation of neurons and glia from multipotential precursors; fourth, apoptotic cell death; fifth, migration of neurons; sixth, guidance of axons to their targets; and seventh, formation of synapses.

  5. ACCELERATING CONSTRUCTION INDUSTRY DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Mohan M. Kumaraswamy

    2006-06-01

    Full Text Available The needs for construction industry development are initially viewed from the broader perspectives of imperatives for infrastructure development and national development. All these are clearly more critical in developing countries. A non-exhaustive set of potential drivers and common barriers to construction industry development is identified from previous research. These suggest the usefulness of consolidating a cluster of recent proposals and exercises aiming at (a construction organization development in terms of an over-arching management support system model, as well as improved information and knowledge management; and (b project team development in the context of relationally integrated teams and supply chains, joint risk management and ‘technology and knowledge exchange’ in joint ventures, as well as longer term public private partnerships. These apparently disparate research thrusts are threaded together into a pattern that may inspire, if not feed, specific research and development (R & D agendas for construction industry development in different countries according to their own priorities, constraints and stages of infrastructure and national development.

  6. Rapid roadway development

    Energy Technology Data Exchange (ETDEWEB)

    David Hainsworth [CSIRO Exploration & Mining (Australia)

    2009-06-15

    A new mining machine, the ACBM, has been developed, which will demonstrate new technologies and will act as a platform for further research and development. With the advent of the ACARP Roadway Development Task Group and the CM2010 project, an ACARP initiative to develop a new mining machine that can operate for 20 hours per day at 10m per hour development rate, it is believed that the Autonomous Conveyor Bolter Module (ACBM) will remain a key potential building block to meet certain CM2010 project targets. The bolt storage and delivery system has been found to be appropriate for further investigation and development as part of ongoing CM2010 studies. This final project reports and discusses the successes of the project; examines the reasons for failure to achieve the initial project objectives; shows how reduced scope objectives were defined; and describes the learnings from this project which will provide a positive influence to the direction of future work.

  7. Cooperative method development

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; Rönkkö, Kari; Eriksson, Jeanette;

    2008-01-01

    research is not easily combined with the improvement orientation of an engineering discipline. During the last 6 years, we have applied an approach we call `cooperative method development', which combines qualitative social science fieldwork, with problem-oriented method, technique and process improvement....... The action research based approach focusing on shop floor software development practices allows an understanding of how contextual contingencies influence the deployment and applicability of methods, processes and techniques. This article summarizes the experiences and discusses the further development......The development of methods tools and process improvements is best to be based on the understanding of the development practice to be supported. Qualitative research has been proposed as a method for understanding the social and cooperative aspects of software development. However, qualitative...

  8. [Moral development in children].

    Science.gov (United States)

    Malá, E

    1989-08-01

    In child psychiatry the developmental aspect is emphasized. Recognition of normal sequence of development in so-called "normal children" makes it possible to reveal pathological conditions (either retardation or acceleration of development, distortion or atypical development). Change-motion-development are philosophical categories considered a manifestation or life--of psychobiological maturation and growth. When investigating the moral development three theories were applied: the developmental theory (Piaget)--learning (Kohlberg), the dynamic theory (Sandler). Among factors which influence in a certain way the moral behaviour the following were selected: age, sex, temperament, family environment. The author describes three stages of moral development in children: preventional stage (moral heteronomy) up to the age of 8 years, conventional and pst conventional (moral autonomy) in adolescence.

  9. Management of Talent Development

    OpenAIRE

    Jindřich, Tomáš

    2009-01-01

    The subject of this text is the management of talent development. The aim of a dissertation was to identify what skills abilities are supposed from Talents in organizations what is suitable to develop in trainings by talents what method of development is most effective for talents and what we should consider hen we set up talent management in organization. The history of talent management manners and current interpretation of keywords are analysed in theoretical part. The hypotheses were set ...

  10. Gallium Arsenide Photocathode Development

    Science.gov (United States)

    1975-10-01

    r ~\\ 1 1 AD-A018 619 ■ i I 1 GALLIUM ARSENIDE PHOTOCATHODE DEVELOPMENT I Terry Roach, et al 1 1 ■f EPSCO ...aiwiiwnHWlffl’Wip m, «swwerf^MW^S’ GALLIUM ARSENIDE PHOTOCATHODE DEVELOPMENT T. J. Roach Bianca Contractor: EPSCO Laboratories Contract Number: F08606...PHOTOCATHODE DEVELOPMENT 7. AUTHORfaJ T. Roach J. Bianca t. PERFORMING ORGANIZATION NAME AND AOORESS EPSCO Laboratories 227 High Ridge Road Stauford CT

  11. Strategy Development in Organisations

    DEFF Research Database (Denmark)

    Sørensen, Lene

    1999-01-01

    " as used in practice and literature. Emphasis is put on how the term is related to the problem, the organisation, the strategy process and the practical way of methodologically developing the strategy. Finally, alternative strategy developing perspectives are presented.......There exist certain ambiguities with the converging fields of information technology and organisational strategy development. The term "IT strategy" has evolved and reflects in some respects this confusion. This paper discusses some of the ambiguities and difficulties of the term "IT strategy...

  12. Equity and development

    OpenAIRE

    2015-01-01

    World Development Report 2006 analyzes the relationship between equity and development. The report documents the persistence of inequality traps by highlighting the interaction between different forms of inequality. It presents evidence that the inequality of opportunity that arises is wasteful and inimical to sustainable development and poverty reduction. It also derivespolicy implications that center on the broad concept of leveling the playing field-both politically and economically and in...

  13. Fusion development and technology

    Energy Technology Data Exchange (ETDEWEB)

    Montgomery, D.B.

    1992-01-01

    This report discusses the following: superconducting magnet technology; high field superconductors; advanced magnetic system and divertor development; poloidal field coils; gyrotron development; commercial reactor studies--aries; ITER physics: alpha physics and alcator R D for ITER; lower hybrid current drive and heating in the ITER device; ITER superconducting PF scenario and magnet analysis; ITER systems studies; and safety, environmental and economic factors in fusion development.

  14. Lean software development

    OpenAIRE

    Hefnerová, Lucie

    2011-01-01

    The main goal of this bachelor thesis is the emergence of the clear Czech written material concerning the concept of Lean Software Development, which has been gaining significant attention in the field of software development, recently. Another goal of this thesis is to summarize the possible approaches of categorizing the concept and to summarize the possible approaches of defining the relationship between Lean and Agile software development. The detailed categorization of the tools potentia...

  15. Development of Miniature Spectrometers

    Institute of Scientific and Technical Information of China (English)

    ZHANG Zhi-guo

    2007-01-01

    Spectrometer is an essential and necessary optical element used for measuring the chemical components and content of the matter.The development of miniature spectrometers can be traced back to 1980s.The development state and different manufacturing methods of micro-spectrometers are presented.Finally,we analyze the miniaturization trend of spectrometers.Some groundwork for the scientific research is offered by introducing micro-spectrometers development.

  16. Climate and development

    Energy Technology Data Exchange (ETDEWEB)

    Biswas, A.K.

    1984-01-01

    The authors review the existing knowledge on the inter-relationships between climate and patterns of development; the impact variables on water and agricultural development; and the effects of climate on human health. A case study is also given of the effect of climatic fluctuations on human population in Mesopotamia. Contents: Climate and Development; Climate and Agriculture; Climate and Water Management; Climate and Health; Effects of Climate Fluctation on Human Populations; Study of Mesopotamian Society.

  17. Strategy Development in Organisations

    DEFF Research Database (Denmark)

    Sørensen, Lene

    1999-01-01

    There exist certain ambiguities with the converging fields of information technology and organisational strategy development. The term "IT strategy" has evolved and reflects in some respects this confusion. This paper discusses some of the ambiguities and difficulties of the term "IT strategy......" as used in practice and literature. Emphasis is put on how the term is related to the problem, the organisation, the strategy process and the practical way of methodologically developing the strategy. Finally, alternative strategy developing perspectives are presented....

  18. Essays in development macroeconomics

    OpenAIRE

    João Moreira Salles

    2012-01-01

    Developing macroeconomics is less about looking for ways to say that economic rules stemming from research in developed countries don\\'t apply to emerging-markets, than it is about trying to understand the many stages these economies go through in the natural course of their development. There are, of course, exceptions, but economic phenomena tend to have common sources. These are, after all, generated by the incentives, designed or natural, that people face when dealing with their day to da...

  19. DEVELOPING THE NEW COUNTRYSIDE

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Dazhai, a mountainous village in north China's Shanxi Province, was an example of China's rural development model under the highly centralized, planned economy in the 1960s-70s. It slid into a lackluster period in the early 1980s after the market economy began to gain ground in China. The resurgence is painstaking but remarkable amid local people's unremitting efforts to develop industry and tourism. The village is now at a moderate development level among counterparts nationwide, according to official s...

  20. Mobile systems development

    DEFF Research Database (Denmark)

    Hosbond, Jens Henrik

    2005-01-01

    This paper takes a systems development perspective on mobility, building on preliminary findings of an on-going multiple case study covering 7 companies. The questions driving this paper are: What are the challenges facing development practice in the mobile industry, how do they affect practice...... and a development dimension. Finally, implications stemming from these challenges are discussed and issues inviting for future research are proposed....

  1. Science and Team Development

    OpenAIRE

    Bryan R. Cole; Ralitsa B. Akins

    2006-01-01

    This paper explores a new idea about the future development of science and teams, and predicts its possible applications in science, education, workforce development and research. The inter-relatedness of science and teamwork developments suggests a growing importance of team facilitators’ quality, as well as the criticality of detailed studies of teamwork processes and team consortiums to address the increasing complexity of exponential knowledge growth and work interdependency. In the fu...

  2. Industrial Engineering and development.

    OpenAIRE

    Carrión Muñoz, Rolando Víctor; Universidad Nacional Mayor de San Marcos

    2014-01-01

    In the mission, approved by consensus, refers that the investigation in the faculty contributes to the “sustainable development of the society”. And according to the industrial engineering professional background of San Marcos University, graduates develop many actions, among others, for the “human development”. This article demonstrates that the human and sustainable development are expressions that have substituted the term “development”, that has been losing its original meaning, as it has...

  3. Developing a paper presentation.

    Science.gov (United States)

    Pierce, L L; Gregg, M M

    1994-01-01

    The purpose of this article is to provide suggestions for developing and presenting papers at an educational conference or other professional meeting. The authors offer suggestions on how to write an abstract, deal with rejection or success, develop an outline, construct a lecture, select audiovisual materials, and use public-speaking skills. The practical strategies described in this article are intended to enable rehabilitation nurses and other readers to develop and/or enhance their paper presentations.

  4. Implementing Sustainable Development Strategies

    Institute of Scientific and Technical Information of China (English)

    Zhang Cuiying

    2004-01-01

    China's national sustainable development strategies were drafted under the guidance of Deng Xiaoping's theory on socialist construction with Chinese distinguishing features and, the theory and practice of sustainable development has further enriched and perfected Deng Xiaoping's theory. An in-depth study of Deng Xiaoping's theory is significant if we are to accurately understand our sustainable development program and how to best implement the strategies.

  5. Node web development

    CERN Document Server

    Herron, David

    2013-01-01

    Presented in a simple, step-by-step format, this book is an introduction to web development with Node.This book is for anybody looking for an alternative to the ""P"" languages (Perl, PHP, Python), or anyone looking for a new paradigm of server-side application development.The reader should have at least a rudimentary understanding of JavaScript and web application development.

  6. Renewable energy project development

    Energy Technology Data Exchange (ETDEWEB)

    Ohi, J.

    1996-12-31

    The author presents this paper with three main thrusts. The first is to discuss the implementation of renewable energy options in China, the second is to identify the key project development steps necessary to implement such programs, and finally is to develop recommendations in the form of key issues which must be addressed in developing such a program, and key technical assistance needs which must be addressed to make such a program practical.

  7. Avionics advanced development strategy

    Science.gov (United States)

    Dyer, D.

    1990-01-01

    Discussed here is the problem of how to put together an integrated, phased, and affordable avionics advanced development program that links and applies to operational, evolving, and developing programs/vehicles, as well as those in the planning phases. Collecting technology needs from individual programs/vehicles and proposed technology items from individual developers usually results in a mismatch and something that is unaffordable. A strategy to address this problem is outlined with task definitions which will lead to avionics advanced development items that will fit within an overall framework, prioritized to support budgeting, and support the scope of NASA space transportations needs.

  8. Pro Access 2010 Development

    CERN Document Server

    Collins, Mark

    2011-01-01

    Pro Access 2010 Development is a fundamental resource for developing business applications that take advantage of the features of Access 2010 and the many sources of data available to your business. In this book, you'll learn how to build database applications, create Web-based databases, develop macros and Visual Basic for Applications (VBA) tools for Access applications, integrate Access with SharePoint and other business systems, and much more. Using a practical, hands-on approach, this book will take you through all the facets of developing Access-based solutions, such as data modeling, co

  9. Agile software development

    CERN Document Server

    Dingsoyr, Torgeir; Moe, Nils Brede

    2010-01-01

    Agile software development has become an umbrella term for a number of changes in how software developers plan and coordinate their work, how they communicate with customers and external stakeholders, and how software development is organized in small, medium, and large companies, from the telecom and healthcare sectors to games and interactive media. Still, after a decade of research, agile software development is the source of continued debate due to its multifaceted nature and insufficient synthesis of research results. Dingsoyr, Dyba, and Moe now present a comprehensive snapshot of the kno

  10. Xcode 5 developer reference

    CERN Document Server

    Wentk, Richard

    2014-01-01

    Design, code, and build amazing apps with Xcode 5 Thanks to Apple's awesome Xcode development environment, you can create the next big app for Macs, iPhones, iPads, or iPod touches. Xcode 5 contains gigabytes of great stuff to help you develop for both OS X and iOS devices - things like sample code, utilities, companion applications, documentation, and more. And with Xcode 5 Developer Reference, you now have the ultimate step-by-step guide to it all. Immerse yourself in the heady and lucrative world of Apple app development, see how to tame the latest features and functions, and find loads of

  11. Preimplantation Development in Primates

    Institute of Scientific and Technical Information of China (English)

    H.B.Croxatto

    1992-01-01

    Essential phenomena involved in preimplamation development, notably cleavageand cell differentiation, are considered from the point of view of their relationships andtheir role in the formation of the blastocyst. The time course of egg transport from theovary to the site of implantation and the requirements.for in vitro development in pri-mate species for which there are some data are compared. Finally the ultrastructural features of human preimptantation development are analyzed, It is concluded that muchmore descriptive information of preimpltmtation development in primates needs to beaccrued to elaborate a comparative view.

  12. Small Business Development Center

    Data.gov (United States)

    Small Business Administration — Small Business Development Centers (SBDCs) provide assistance to small businesses and aspiring entrepreneurs throughout the United States and its territories. SBDCs...

  13. Visualforce development cookbook

    CERN Document Server

    Bowden, Keir

    2013-01-01

    Visualforce Development Cookbook is written in such a way that even complex concepts are explained in an easy-to-understand manner. Following a Cookbook structure, the book covers some essential technical scenarios and includes over 75 recipes focusing on real-world development problems. This book is packed with illustrations and also contains lots of code samples for the better understanding of the reader.""Visualforce Development Cookbook"" is aimed at developers who have already grasped the basics of Visualforce. Awareness of the standard component library and the purpose of controllers is

  14. Global product development

    DEFF Research Database (Denmark)

    Taylor, Thomas Paul; Ahmed-Kristensen, Saeema

    2016-01-01

    Selecting key performance indicators in conventional product development is a challenging task for project management and is compound by global product development. Informed from the findings of two in depth case studies conducted with large Danish manufacturing companies, in this paper we develop...... and test a framework that supports the selection of Leading and Lagging key performance indicators in global product development. The framework provides an alternative approach to design, select and document key performance indicators by incorporating a challenge-oriented approach to selection....

  15. Thallium Mercury Laser Development.

    Science.gov (United States)

    1980-04-17

    AD-A9 840 WESTINGHOUSE RESEARCH AND DEVELOPMENT CENTER PITTSBU--ETC F/A 20/5 THALLIUM MERCURY LASER DEVELOPMENT .(U) APR 80 C S LIU, D W FELDMAN, J L...PACK NO001I78-C-0131 lIlrt A nEQE-WOTFX-R NL THALLIUM MERCURY LASER DEVELOPMENT C. S. Liu, D. W. Feldman and J. L. Pack FINAL REPORT (PHASE II...PERIOD COVERED Thallium Mercury Laser Development -T- Final Report (Phase II) Feb. 1, 1979 to Jan. 31, 1980 77a. w-atF. -REPORT NUMBER _,___C2-OTEX

  16. Continuous Platform Development

    DEFF Research Database (Denmark)

    Nielsen, Ole Fiil

    low risks and investments but also with relatively fuzzy results. When looking for new platform projects, it is important to make sure that the company and market is ready for the introduction of platforms, and to make sure that people from marketing and sales, product development, and downstream......, but continuous product family evolution challenges this strategy. The concept of continuous platform development is based on the fact that platform development should not be a one-time experience but rather an ongoing process of developing new platforms and updating existing ones, so that product family...

  17. Auto Industry Development Policy

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    <正> Decree No. 8The National Development and Reform CommissionThe People’s Republic of ChinaAccording to the Document [2004] 30 of the State Council, the Auto Industry Development Policy has passed the examination of the Sitate Development and Reform Commission and been approved by the State Council. Now it is issued and shall be effective as of the date of promulgation. The Auto Industrial Policies implemented since 1994 should end as of the date of this promulgation.MAKaiDirector of the National Development and Reform CommissionMay 21, 2004

  18. REGIONAL DEVELOPMENT STRATEGY

    Directory of Open Access Journals (Sweden)

    Vaduva Maria

    2011-01-01

    Full Text Available Regional development policies in the EU Member States have included tools whoseimportance varied from one country to another. Can be identified by negative incentives forregional development policy towards location in crowded areas or control over the location,the reallocation of economic activities in national territory, creation of adequateinfrastructure, measures to enhance development, financial incentives granted toenterprises. Sustainable business development, rehabilitation of social infrastructure,including social housing and improved social services. Improved regional and localtransportation are key areas of intervention rehabilitation and upgrading of county roads,city streets, including road construction and rehabilitation of belt.

  19. Medicines in Development

    Science.gov (United States)

    ... Drug Misuse, Abuse & Disposal Drug Importation Drug Shortages & Supply Chain Info Research & Development Overview FDA Modernization PDUFA Biologics & Biosimilars Regulatory Harmonization Clinical ...

  20. Creativity and Strategy Development

    DEFF Research Database (Denmark)

    Sørensen, Lene Tolstrup; Vidal, Rene Victor Valqui

    This paper focus on how creative thinking, processes and methods can support the strategy development and planning process in organisations. First, several fundamental concepts related to both strategy development and planning are stipulated. In addition, the concept of living organisation...... will be discussed as well as the interaction between strategy and creativity. Then, methodological ideas to support the strategy making process are presented enhancing the use of creative methods and tools. Finally, a case study related to the development of a strategy for organisational development using...... creativity tools is discussed....

  1. Six Sigma software development

    CERN Document Server

    Tayntor, Christine B

    2002-01-01

    Since Six Sigma has had marked success in improving quality in other settings, and since the quality of software remains poor, it seems a natural evolution to apply the concepts and tools of Six Sigma to system development and the IT department. Until now however, there were no books available that applied these concepts to the system development process. Six Sigma Software Development fills this void and illustrates how Six Sigma concepts can be applied to all aspects of the evolving system development process. It includes the traditional waterfall model and in the support of legacy systems,

  2. Shopify application development

    CERN Document Server

    Larkin, Michael

    2014-01-01

    This is an easy-to follow manual that will guide you through the entire process of application development with Shopify, beginning with the installation and configuration of your local development environment for your app to the deployment of the app to Heroku. If you are a web developer or a designer who wants to extend Shopify stores by building apps, then this book is for you. A basic understanding of programming concepts and some familiarity with Shopify is all that is required to get started with Shopify app development.

  3. Elements of the Yue Culture in Jade Ornaments in the Ancient Yun- nan-Guizhou Plateau%云贵高原古代玉饰的越文化因素

    Institute of Scientific and Technical Information of China (English)

    杨建芳

    2004-01-01

    In remote antiquity, members of the Yue people in the region south of the Five Ridges migrated westward by the water route of Xijiang-Yujiang-Yongjiang-Youjiang and settled in the Yunnan-Guizhou Plateau. This led to the wide spread of the jades originally prevailing in the territory ofthe Yue people, such as "horned", crescent and square jue penannular ornaments, necked bracelets and mushroom-shaped fittings for sword butt-ends. With the development of amalgamation of ethnic groups, these types of jades (along with a few antler artifacts) became ornaments of the natives in the Yunnan-Guizhou Plateau, including the Yelang, Dian, Qiongdu and Quting groups.

  4. Population, environment and development.

    Science.gov (United States)

    Karkal, M

    1994-06-01

    Western development models label subsistence economies, which do not participate in the market economy on a grand scale and do not consume commodities produced for and distributed through the market, to be poor. Yet, subsistence does not always indicate a low quality of life. The Western development process has destroyed wholesome and sustainable lifestyles. In India, the Green Revolution caused many small farmers to lose their land. In comparison to traditional economies, industrial economies have longer technological chains dependent on higher energy and resource inputs and exclude large numbers of people without power to buy goods. Further, they generate new and artificial needs, necessitating increased production of industrial goods and services. They erode resource bases for survival. This erosion is marginalizing people who were traditionally in nature's economy. Developed countries did not deliver 0.15% of their GNP to development projects in developing countries as promised. The US made population growth in these countries its cause. The UN and other multinational agencies during 1962-1972, at the US's request, began to support population and family planning programs in developing countries. These countries opposed the 1st draft at the 1974 Bucharest Population Conference, but by the conference in Mexico City, most supported the need for family planning. Yet, the US politicized this conference and had a greater say in the recommendations than did developing countries. Structural adjustments and external debt repayments required of developing countries in the 1980s set them back. In fact, the number of developing countries increased from 31 to 42. The UN recognizes the right to development, but social inequalities are barriers to this right. If environmental degradation continues, poverty will only increase. Women's groups are playing a great role in preparations for the International Conference on Population and Development in Cairo in September 1994.

  5. Evaluating professional development

    CERN Document Server

    Guskey, Thomas R

    2000-01-01

    This is a practical guide to evaluating professional development programs at five increasing levels of sophistication: participants' reaction to professional development; how much participants learned; evaluating organizational support and change; how participants use their new knowledge and skills; and improvements in student learning.

  6. Data Centric Development Methodology

    Science.gov (United States)

    Khoury, Fadi E.

    2012-01-01

    Data centric applications, an important effort of software development in large organizations, have been mostly adopting a software methodology, such as a waterfall or Rational Unified Process, as the framework for its development. These methodologies could work on structural, procedural, or object oriented based applications, but fails to capture…

  7. Globalization, consumption, development

    NARCIS (Netherlands)

    Binsbergen, van W.M.J.; Fardon, R.; Binsbergen, van W.M.J.; Dijk, van R.A.

    1999-01-01

    The papers collected in this volume were first presented at a conference on 'Globalization, development and the making of consumers: what are collective identities for?' which was held in The Hague, The Netherlands, on 13-16 March 1997. The papers are concerned with the challenge to the development

  8. Improving Software Developer's Competence

    DEFF Research Database (Denmark)

    Abrahamsson, Pekka; Kautz, Karlheinz; Sieppi, Heikki

    2002-01-01

    Emerging agile software development methods are people oriented development approaches to be used by the software industry. The personal software process (PSP) is an accepted method for improving the capabilities of a single software engineer. Five original hypotheses regarding the impact...

  9. Consuming technologies - developing routines

    DEFF Research Database (Denmark)

    Gram-Hanssen, Kirsten

    2008-01-01

    Routines in daily life are crucial for consumption by households of energy and water and therefore knowledge of how routines develop and change is extremely relevant from a sustainable consumption perspective. Routines emerge, develop and change in close relation with different kinds of everyday ...

  10. Arenas of Development

    DEFF Research Database (Denmark)

    Jørgensen, Ulrik; Sørensen, Ole Henning

    2002-01-01

    The Arena of Development constitutes a cognitive space for innovation and shaping of technology. The article presents and debate the notion of development arena and explores the nature of locations and spaces where technology and innovation can be mapped, analysed and managed....

  11. Culture and Development

    NARCIS (Netherlands)

    D.R. Gasper (Des)

    2006-01-01

    textabstractDiscourses on culture and development vary according to their conceptions of culture and of development and according to their standpoint. The ‘culture and development’ problematic has typically: (1) arisen from a conception of ‘culture’ as a relatively fixed, homogeneous set of mental

  12. Develop your presentation skills

    CERN Document Server

    Theobald, Theo

    2016-01-01

    Going beyond handling nerves and presenting PowerPoint slides, the third edition of "Develop Your Presentation Skills "offers practical advice on developing a captivating presentation, constructing compelling content, and boosting self-confidence. The book includes three new chapters on delivering a "stripped down"presentation, using new media to engage with the audience, and handling being asked to present on short notice."

  13. CMMs Development Activities

    Institute of Scientific and Technical Information of China (English)

    HU Jun; HU Yefa; HUANG Anyi

    2006-01-01

    The coordinate measuring machine (CMM) has been an important role in the digital manufacturing. This paper reviews CMM early stage development history and current activities. The authors provide some ideas about the areas that academic research can help to the CMMs development.

  14. Globalization, consumption, development

    NARCIS (Netherlands)

    Binsbergen, van W.M.J.; Fardon, R.; Binsbergen, van W.M.J.; Dijk, van R.A.

    1999-01-01

    The papers collected in this volume were first presented at a conference on 'Globalization, development and the making of consumers: what are collective identities for?' which was held in The Hague, The Netherlands, on 13-16 March 1997. The papers are concerned with the challenge to the development

  15. Sustainable development and law

    NARCIS (Netherlands)

    Peeters, M.G.W.M.; Schomerus, Th.; Heinrichs, H.; Martens, P.; Michelsen, G.; WIek, A.

    2016-01-01

    Since the emergence of the concept of sustainable development, lawyers across the globe are trying to come to grips with its legal status and the potential legal consequences. Nowadays, the concept of sustainable development is represented in legally binding texts at international, European, and nat

  16. Youth Development: Maori Styles

    Science.gov (United States)

    Ware, Felicity; Walsh-Tapiata, Wheturangi

    2010-01-01

    Despite the innovative approach of the Youth Development Strategy Aotearoa and the applicability of its Rangatahi Development Package, the diverse realities and experiences of Maori youth are still presenting unique challenges to national policy in Aotearoa New Zealand. A Maori youth research approach that utilised a combination of action research…

  17. Competence development in UAS

    DEFF Research Database (Denmark)

    Thorslund, Jørgen; Brodersen, Anne Mygind

    2011-01-01

    As a University of Applied Science (UAS) University College Lillebaelt in Denmark is addressing education, knowledge production and professional development in perspective of life-long and life-wide learning. It is our basic assumption that that internal competence development ? individually...

  18. Improving Software Developer's Competence

    DEFF Research Database (Denmark)

    Abrahamsson, Pekka; Kautz, Karlheinz; Sieppi, Heikki

    2002-01-01

    Emerging agile software development methods are people oriented development approaches to be used by the software industry. The personal software process (PSP) is an accepted method for improving the capabilities of a single software engineer. Five original hypotheses regarding the impact...

  19. Livelihoods in Development

    NARCIS (Netherlands)

    L.J. de Haan (Leo)

    2015-01-01

    textabstractThe world is changing rapidly and so is the field of development studies. When I started my university studies and became interested in what was then called ‘issues of development and underdevelopment’, the map of the world I had grown up with was simple and orderly. It was conveniently

  20. Livelihoods in Development

    NARCIS (Netherlands)

    L.J. de Haan (Leo)

    2015-01-01

    textabstractThe world is changing rapidly and so is the field of development studies. When I started my university studies and became interested in what was then called ‘issues of development and underdevelopment’, the map of the world I had grown up with was simple and orderly. It was conveniently

  1. Emigration for Development?

    DEFF Research Database (Denmark)

    Careja, Romana

    2013-01-01

    is necessary if resources from emigration are to become seeds for development. By analysing the case of Romania, one of the largest labour sending countries in Eastern Europe, it argues that its laissez-faire approach is likely not enough to capitalize on emigrants' resources for development. International...

  2. DEVELOPMENT, DIFFUSION, AND EVALUATION.

    Science.gov (United States)

    GUBA, EGON G.

    THE KNOWLEDGE GAP BETWEEN INITIAL RESEARCH AND FINAL USE IS DISCUSSED IN TERMS OF THE FOUR STATES OF THE THEORY-PRACTICE CONTINUUM (RESEARCH, DEVELOPMENT, DIFFUSION, AND ADOPTION). THE TWO MIDDLE STAGES ARE EMPHASIZED. RESEARCH AND DEVELOPMENT CENTERS, REGIONAL EDUCATIONAL LABORATORIES, AND TITLE III PROJECTS ARE SUGGESTED AS AGENCIES RESPONSIBLE…

  3. Microsoft Azure development cookbook

    CERN Document Server

    Freato, Roberto

    2014-01-01

    If you are an architect, this book will help you make the correct decisions about which Azure building blocks to use. If you are a developer, this book will help you understand how to use them appropriately, and if you are a .NET developer, this book is a pure delight.

  4. Development of MPPC

    Indian Academy of Sciences (India)

    Tohru Takeshita

    2007-12-01

    For fine segmented scintillator calorimeter, we need semiconductor-based photon sensor. Progress for MPPC which is developed in Japan is presented. One of the results which is relevant to photon detection efficiency indicates promising future of MPPC. However, further development is required for the dynamic range and operating voltage value.

  5. Pathways of Language Development.

    Science.gov (United States)

    Australian Council for Educational Research, Hawthorn.

    Prepared by teachers for teachers, this practical classroom guide offers a process of monitoring language development and planning for development within a whole language framework, supported by a compendium of appropriate practice to be drawn on when needed. The guide (1) emphasizes the interdependence of reading, writing, talking, and listening;…

  6. Towards ``Astronomy for Development''

    Science.gov (United States)

    Govender, Kevin

    2016-10-01

    The ambition of the IAU's decadal strategic plan is to use astronomy to stimulate development globally. The Office of Astronomy for Development was established in 2011 to implement this visionary plan. This talk will reflect on the past, present and future activities of the office, and describe the status of implementation of the plan at this halfway point in the 2010- decade.

  7. Technical Assistance to Developers

    Energy Technology Data Exchange (ETDEWEB)

    Rockward, Tommy [Los Alamos National Laboratory; Borup, Rodney L. [Los Alamos National Laboratory; Garzon, Fernando H. [Los Alamos National Laboratory; Mukundan, Rangachary [Los Alamos National Laboratory; Spernjak, Dusan [Los Alamos National Laboratory

    2012-07-17

    This task supports the allowance of technical assistance to fuel-cell component and system developers as directed by the DOE. This task includes testing of novel materials and participation in the further development and validation of single cell test protocols. This task also covers technical assistance to DOE Working Groups, the U.S. Council for Automotive Research (USCAR) and the USCAR/DOE Driving Research and Innovation for Vehicle efficiency and Energy sustainability (U.S. Drive) Fuel Cell Technology Team. Assistance includes technical validation of new fuel cell materials and methods, single cell fuel cell testing to support the development of targets and test protocols, and regular advisory participation in other working groups and reviews. This assistance is made available to PEM fuel cell developers by request and DOE Approval. The objectives are to: (1) Support technically, as directed by DOE, fuel cell component and system developers; (2) Assess fuel cell materials and components and give feedback to developers; (3) Assist the DOE Durability Working Group with the development of various new material durability Testing protocols; and (4) Provide support to the U.S. Council for Automotive Research (USCAR) and the USCAR/DOE Fuel Cell Technology Team. FY2012 specific technical objectives are: (1) Evaluate novel MPL materials; (2) Develop of startup/ shutdown protocol; (3) Test the impact of hydrophobic treatment on graphite bi-polar plates; (4) Perform complete diagnostics on metal bi-polar plates for corrosion; and (5) Participate and lead efforts in the DOE Working Groups.

  8. Compassion and Moral Development.

    Science.gov (United States)

    Susky, John E.

    1979-01-01

    Critiquing Skinner's and Kohlberg's moral development theories as inadequate, the author asserts that affective development (compassion, empathy, caring) is necessary to moral action. While saying that schools are limited in their ability to provide moral education, he outlines qualities of an educational environment which could facilitate moral…

  9. EMI Registry Development Plan

    CERN Document Server

    Memon, S.; Szigeti, G.; Field, L.

    2012-01-01

    This documents describes the overall development plan of the EMI Registry product, the plan focuses on the realisation of the EMI Registry specification as defined in the document. It is understood that during the course of the development phase the specification will likely evolve and the changes will be fed into the specification document.

  10. The Electric Vehicle Development

    DEFF Research Database (Denmark)

    Wang, Jingyu; Liu, Yingqi; Kokko, Ari

    2014-01-01

    In order to respond to the energy crisis and environment problem, countries carry out their research and promotion about electric vehicles. As the ten cities one thousand new energy buses started in 2009, the new energy vehicles have been greatly developed in China, while the development of elect...

  11. Physical Development: Thinking Physically

    Science.gov (United States)

    Strickland, Erik

    2005-01-01

    Children grow and develop physically according to their own experiences, characteristics, and abilities. Physical development is so important and the environment should allow each child to find her space in the sunshine. This can be done by: (1) creating the right outdoor environment; (2) allowing children time to use it; (3) encouraging movement…

  12. Developing Successful Global Leaders

    Science.gov (United States)

    Training, 2011

    2011-01-01

    Everyone seems to agree the world desperately needs strong leaders who can manage a global workforce and all the inherent challenges that go with it. That's a big part of the raison d'etre for global leadership development programs. But are today's organizations fully utilizing these programs to develop global leaders, and, if so, are they…

  13. Why Professional Development Matters

    Science.gov (United States)

    Mizell, Hayes

    2010-01-01

    Professional development refers to many types of educational experiences related to an individual's work. Doctors, lawyers, educators, accountants, engineers, and people in a wide variety of professions and businesses participate in professional development to learn and apply new knowledge and skills that will improve their performance on the job.…

  14. Adaptive urban development

    NARCIS (Netherlands)

    Dr. ing Rutger de Graaf

    2012-01-01

    Adaptive urban development is the design, construction and continuing evolution of urban areas to anticipate and react to changes in the environment and society. These changes include both processes within the city itself and external developments. It is expected that until 2100 a total of 5 billion

  15. Update on World Development.

    Science.gov (United States)

    Social Education, 1996

    1996-01-01

    Summarizes a wealth of statistical information concerning the economic development and debt for a number of developing nations. Includes statistics on the gross national product growth of Cote d'lvoire, Guatemala, Malaysia, Korea, Colombia, and Nigeria, as well as, the gross domestic product growth and debt service for Latin America, Africa, and…

  16. Beijing Development Zones

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Beijing Badaling Development Area The Development Area is planned to cover an area of 6.56 km2.Currently,more than 300 enterprises have located in the area.Their investments add up to about RMB 1 billion.Major business trades include machine building,mineral ore processing,medicine,electronic parts,foodstuff processing,and warehousing transportation.

  17. concrete5 for developers

    CERN Document Server

    Uzayr, Sufyan bin

    2014-01-01

    Whether you have had some previous experience with concrete5 or are entirely new to it, this book will help you understand all that you need to know in order to get started with concrete5 development. A background in PHP is required; some knowledge of HTML/CSS is needed in order to fully grasp the concepts underlying concrete5 theme development.

  18. On Developing Students Thinking

    Institute of Scientific and Technical Information of China (English)

    牟兰

    2015-01-01

    With the development of English teaching, English teaching methods have been paid more and more attention to. Language learning is a complicated process, creative thinking is very important for students to learn language. According to analyzing several factors of affecting students' thinking, the author points out five areas of suggestions on developing students' thinking in this paper.

  19. Adolescent Development Reconsidered.

    Science.gov (United States)

    Gilligan, Carol

    1987-01-01

    Emphasizes necessity of reconsideration of adolescent development, for these reasons: the view of childhood has changed; females have not been systematically studied; theories of cognitive development favor mathematical and scientific thinking over the humanities; and because the psychology of adolescence is anchored in separation and independence…

  20. Caribbean development: an overview

    Directory of Open Access Journals (Sweden)

    Paul Sutton

    2008-12-01

    Full Text Available Reviews development in the Caribbean, especially since 1990 to the present, and highlights future development prospects. Author discusses 2 reports from 2005 on present developments problems in the Caribbean region: the economics-focussed 'A time to choose: Caribbean development in the 21st century' by the World Bank, and the UN ECLAC report 'The Millennium Development Goals: a Latin American and Caribbean perspective', with a broader, also social and political, development agenda. He relates what both reports recommend for the Caribbean on the basis of their evaluations of past development. The World Bank report advocates a move toward the services sector, including tourism, offshore education, ICT services, and health services as most viable. The ECLAC report notes some social and political advances in comparison to other developing countries, but also remaining problems and inequalities. The author finds that the World Bank report's neoliberal, one-size-fits-all approach is not mindful of specific Caribbean realities, while the ECLAC study is more sensitive to local realities, and espouses a mixed economy. He thus considers the ECLAC approach preferable, but argues that it needs to go further, as it excludes Cuba and Haiti as atypical states.

  1. Ecoregional research for development

    NARCIS (Netherlands)

    Bouma, J.; Stoorvogel, J.J.; Quiroz, R.; Staal, S.; Herrero, M.; Immerzeel, W.; Roetter, R.P.; Bosch, van den H.; Sterk, G.; Rabbinge, R.; Chater, S.

    2007-01-01

    This chapter focuses on the subject of ecoregional research for development. The character of international agricultural research has changed profoundly in the last decades of the twentieth century. This can be illustrated by developments within the Consultative Group on International Agricultural

  2. Development of opencast mines

    Energy Technology Data Exchange (ETDEWEB)

    Szebenyi, F.

    1987-01-01

    The role and works of the Central Institute for Mining Development and its legal predecessors, the Mining Research Institute and Mines Design Institute, in relation with opencast lignite mining in Hungary, are summarized. Investigations aimed at the determination of the heating technical properties of lignites are reviewed. Different lignite mines, their geological features, production possibilities and development conditions are outlined.

  3. Development Expert System

    Institute of Scientific and Technical Information of China (English)

    CAI Heng

    2010-01-01

    The expert system is a high-level technology.It is a sub-field of artificial intelligence.We demonstrated the character and software evaluation,carrying out an initial study of expert system.A good development expert system was developed.

  4. Developing Successful Global Leaders

    Science.gov (United States)

    Training, 2011

    2011-01-01

    Everyone seems to agree the world desperately needs strong leaders who can manage a global workforce and all the inherent challenges that go with it. That's a big part of the raison d'etre for global leadership development programs. But are today's organizations fully utilizing these programs to develop global leaders, and, if so, are they…

  5. Environment and Alternative Development.

    Science.gov (United States)

    Kothari, Rajni

    Stressing the global dimension to the adversary relationship between economic development and environmental conservation, this monograph examines the philosophical, historical, cultural, and ethnic underpinnings of modern science and technology. In addition, the monograph spells out policy implications of an alternative concept of development and…

  6. Early Developments, 2002.

    Science.gov (United States)

    Winton, Pam, Ed.; Buysse, Virginia, Ed.

    2002-01-01

    This document consists of the three 2002 issues of a journal reporting new research in early child development conducted by the Frank Porter Graham Child Development Center (FPG) at the University of North Carolina at Chapel Hill. Articles in the Winter 2002 issue highlight some current work at FPG on factors that enhance or inhibit social and…

  7. Developing Parallel Programs

    Directory of Open Access Journals (Sweden)

    Ranjan Sen

    2012-09-01

    Full Text Available Parallel programming is an extension of sequential programming; today, it is becoming the mainstream paradigm in day-to-day information processing. Its aim is to build the fastest programs on parallel computers. The methodologies for developing a parallelprogram can be put into integrated frameworks. Development focuses on algorithm, languages, and how the program is deployed on the parallel computer.

  8. Handbook of Moral Development

    Science.gov (United States)

    Killen, Melanie; Smetana, Judith

    2006-01-01

    The psychological study of moral development has expanded greatly, both in terms of the diversity of theoretical perspectives that are represented in the field, as well as in the range of topics that have been studied. This "Handbook of Moral Development" represents the diversity and multidisciplinary influences on current theorizing about the…

  9. Voice search for development

    CSIR Research Space (South Africa)

    Barnard, E

    2010-09-01

    Full Text Available In light of the serious problems with both illiteracy and information access in the developing world, there is a widespread belief that speech technology can play a significant role in improving the quality of life of developing-world citizens...

  10. Character and Moral Development.

    Science.gov (United States)

    Denton, Johnnie

    1997-01-01

    Reflects on the ways in which children develop character as well as ways to foster moral development in elementary education communities. Includes a brief discussion of Robert Coles' documentation of moral intelligence in children, and lists several ways to aid the moral life of children in Montessori classrooms. (EV)

  11. Graphite technology development plan

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1986-07-01

    This document presents the plan for the graphite technology development required to support the design of the 350 MW(t) Modular HTGR within the US National Gas-Cooled Reactor Program. Besides descriptions of the required technology development, cost estimates, and schedules, the plan also includes the associated design functions and design requirements.

  12. Development of geothermal resources

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    This paper describes the geothermal development promotion survey project. NEDO is taking the lead in investigation and development to reduce risks for private business entities and promote their development. The program is being moved forward by dividing the surveys into three ranks of A, B and C from prospects of geothermal resource availability and the state of data accumulation. The survey A lacks number of data, but covers areas as wide as 100 to 300 km{sup 2}, and studies possible existence of high-temperature geothermal energy. The survey B covers areas of 50 to 70 km{sup 2}, investigates availability of geothermal resources, and assesses environmental impacts. The survey C covers areas of 5 to 10 km{sup 2}, and includes production well drilling and long-term discharge tests, other than those carried out by the surveys A and B. Results derived in each fiscal year are evaluated and judged to establish development plans for the subsequent fiscal year. This paper summarizes development results on 38 areas from among 45 areas surveyed since fiscal 1980. Development promotion surveys were carried out over seven areas in fiscal 1994. Development is in progress not only on utilization of high-temperature steam, but also on binary cycle geothermal power generation utilizing hot waters of 80 to 150{degree}C. Fiscal 1994 has carried out discussions for spread and practical use of the systems (particularly on economic effects), and development of small-to-medium scale binary systems. 2 figs., 1 tab.

  13. Wind energy technology developments

    DEFF Research Database (Denmark)

    Madsen, Peter Hauge; Hansen, Morten Hartvig; Pedersen, Niels Leergaard

    2014-01-01

    turbine blades and towers are very large series-produced components, which costs and quality are strongly dependent on the manufacturing methods. The industrial wind energy sector is well developed in Denmark, and the competitive advantage of the Danish sector and the potential for job creation......This chapter describes the present mainstream development of the wind turbine technology at present. The turbine technology development trend is characterized by up-scaling to turbines with larger capacity for both onshore and offshore applications, larger rotors and new drivetrain solution......, including the direct-drive solution without gearbox. The technology solutions are strongly influenced by the development of the international industry with a global market for components and a trend towards a “shared” development effort in collaboration between the OEM’s and component sub-suppliers. Wind...

  14. Urban Quality Development & Management

    DEFF Research Database (Denmark)

    Lehmann, Martin; Fryd, Ole

    2008-01-01

    Purpose: The purpose of this article is to describe and discuss the development and the structure of a new international master on the subject of Urban Quality Development & Management, and explore the potential of the process and the outcome in serving as models adoptable by faculty at other...... universities. Design/methodology/approach: The study has been carried out as action research. Using innovation and user-producer interaction as the framework, the authors present the development process; the structure, contents and methodology of the programme; and report on their research findings. Findings......: Urban quality development and management is dependent on human resource development, institutionalised networks and confident exchange of knowledge, and must identify and incorporate multiple environmental, social, economic and cultural aspects. The authors find that at the core of innovative societies...

  15. Xenopus pancreas development.

    Science.gov (United States)

    Pearl, Esther J; Bilogan, Cassandra K; Mukhi, Sandeep; Brown, Donald D; Horb, Marko E

    2009-06-01

    Understanding how the pancreas develops is vital to finding new treatments for a range of pancreatic diseases, including diabetes and pancreatic cancer. Xenopus is a relatively new model organism for the elucidation of pancreas development, and has already made contributions to the field. Recent studies have shown benefits of using Xenopus for understanding both early patterning and lineage specification aspects of pancreas organogenesis. This review focuses specifically on Xenopus pancreas development, and covers events from the end of gastrulation, when regional specification of the endoderm is occurring, right through metamorphosis, when the mature pancreas is fully formed. We have attempted to cover pancreas development in Xenopus comprehensively enough to assist newcomers to the field and also to enable those studying pancreas development in other model organisms to better place the results from Xenopus research into the context of the field in general and their studies specifically. Developmental Dynamics 238:1271-1286, 2009. (c) 2009 Wiley-Liss, Inc.

  16. Universities as Development Hubs

    DEFF Research Database (Denmark)

    Hansen, Jens Aage; Lindegaard, Klaus; Lehmann, Martin

    2005-01-01

    by references. Strengthening of tertiary education is assumed to be a prerequisite for economic and democratic development in all countries, be they industrialised, in transition or developing. However, particularly in transition and developing countries there is a need for special support, e.g. through...... been promising in terms of concrete results within each type of activity and together they provide vital steps in capacity-building in tertiary education to the benefit of development and environment. Some of the results and their implications are presented in this chapter and more are documented...... international aid programmes to tertiary education, including research and innovation in an interplay with other research institutions and business. In the absence of such support the so-called digital divide between industrial and developing and transition countries will widen, and brain-drain and poverty...

  17. Community Development in lreland

    Directory of Open Access Journals (Sweden)

    Liam Carey

    1996-12-01

    Full Text Available Community Development is about enabling people to actively participate in shaping the society of which they area part. Primarily the program focussed mainly on disadvantaged communities. It has been recognized that the ability to participate fully in society is open more to some groups and individuals than others. Social exclusion has many different dimensions: Jack of money, isolation, powerlessness, poor access to basic public services such as health, education, legal aid, arts and culture ... In the first place community development is based on education, being closely related to the local development concept. It recognizes and meets educational needs of the members of certain community. Such programmes result especially in a community's political development, development of its capacities, potentials and creativity, enhancement of the structures, important for the long-term functioning of the community.

  18. Developable algebraic surfaces

    Institute of Scientific and Technical Information of China (English)

    CHEN Dongren; WANG Guojin

    2004-01-01

    An algebraic surface can be defined by an implicit polynomial equation F(x,y,z)=0. In this paper, general characterizations of developable algebraic surfaces of arbitrary degree are presented. Using the shift operators of the subscripts of Bézier ordinates, the uniform apparent discriminants of developable algebraic surfaces to their Bézier ordinates are given directly. To degree 2 algebraic surfaces, which are widely used in computer aided geometric design and graphics, all possible developable surface types are obtained. For more conveniently applying algebraic surfaces of high degree to computer aided geometric design, the notion of ε-quasi-developable surfaces is introduced, and an example of using a quasi-developable algebraic surface of degree 3 to interpolate three curves of degree 2 is given.

  19. Laser Cutting, Development Trends

    DEFF Research Database (Denmark)

    Olsen, Flemming Ove

    1999-01-01

    In this paper a short review of the development trends in laser cutting will be given.The technology, which is the fastest expanding industrial production technology will develop in both its core market segment: Flat bed cutting of sheet metal, as it will expand in heavy industry and in cutting o...... of 3-dimensional shapes.The CO2-laser will also in the near future be the dominating laser source in the market, although the new developments in ND-YAG-lasers opens for new possibilities for this laser type.......In this paper a short review of the development trends in laser cutting will be given.The technology, which is the fastest expanding industrial production technology will develop in both its core market segment: Flat bed cutting of sheet metal, as it will expand in heavy industry and in cutting...

  20. Financing Sustainable Development

    DEFF Research Database (Denmark)

    Fejerskov, Adam Moe; Funder, Mikkel; Engberg-Pedersen, Lars

    In the fall of 2015, world leaders adopted the most ambitious global development agenda in history. Meeting the aspiring targets of the Sustainable Development Goals will require financing far beyond traditional aid. At the same time, aid itself is under major pressure as European governments cut...... aid budgets or divert them to meet refugee and migration issues. In this context of massive global ambition and concurrent uncertainty on the future of aid, other actors and sources of development financing seem ever more critical, such as the private sector, private foundations and the BRICS....... But what are in fact the interests and modes of operation of such actors in the context of development financing, and to what extent do they align with the aims of the SDGs? And how do national governments of developing countries themselves perceive and approach these new sources of financing?...

  1. Global product development

    DEFF Research Database (Denmark)

    Hansen, Zaza Nadja Lee; Ahmed-Kristensen, Saeema

    2011-01-01

    Globalisation has enabled companies to globalise their product development process. Today, everything from manufacturing to R&D can be globally distributed. This has led to a more complex and disintegrated product development process. This paper investigates the impacts companies have experienced...... operational solutions to counteract the negative impacts with varying degrees of success. This paper presents a unique look into global product development through an investigation of its impact on the organisation, the product development process, and the product. Furthermore, it shows the solutions...... as a result of this, and how they have been addressed. Data was collected through case studies of five Danish multinational corporations. The findings showed that the companies experienced several challenges when they globalised their product development process. They consequently implemented various...

  2. Finance and Economic Development

    Directory of Open Access Journals (Sweden)

    Ugo Panizza

    2012-03-01

    Full Text Available Published by Palgrave MacmillanThis chapter reviews the literature on finance and economic development. It starts with a description of the roles of finance, a definition of financial efficiency, and a discussion of whether countries may have financial sectors that are ‘too large’ compared to the size of the domestic economy. Next, the author describes several indicators of financial development and reviews the literature on the relationship between financial development and economic growth. In the literature review, he discusses in detail some recent evidence indicating that the marginal contribution of financial development to gross domestic product (GDP growth becomes negative when credit to the private sector reaches 110 per cent of GDP. The chapter concludes with some policy conclusions targeted to developing countries.

  3. Liga developer apparatus system

    Science.gov (United States)

    Boehme, Dale R.; Bankert, Michelle A.; Christenson, Todd R.

    2003-01-01

    A system to fabricate precise, high aspect ratio polymeric molds by photolithograpic process is described. The molds for producing micro-scale parts from engineering materials by the LIGA process. The invention is a developer system for developing a PMMA photoresist having exposed patterns comprising features having both very small sizes, and very high aspect ratios. The developer system of the present invention comprises a developer tank, an intermediate rinse tank and a final rinse tank, each tank having a source of high frequency sonic agitation, temperature control, and continuous filtration. It has been found that by moving a patterned wafer, through a specific sequence of developer/rinse solutions, where an intermediate rinse solution completes development of those portions of the exposed resist left undeveloped after the development solution, by agitating the solutions with a source of high frequency sonic vibration, and by adjusting and closely controlling the temperatures and continuously filtering and recirculating these solutions, it is possible to maintain the kinetic dissolution of the exposed PMMA polymer as the rate limiting step.

  4. The development of colliders

    Energy Technology Data Exchange (ETDEWEB)

    Sessler, A.M.

    1993-02-01

    Don Kerst, Gersh Budker, and Bruno Touschek were the individuals, and the motivating force, which brought about the development of colliders, while the laboratories at which it happened were Stanford, MURA, the Cambridge Electron Accelerator, Orsay, Frascati, CERN, and Novosibirsk. These laboratories supported, during many years, this rather speculative activity. Of course, many hundreds of physicists contributed to the development of colliders but the men who started it, set it in the right direction, and forcefully made it happen, were Don, Gersh, and Bruno. Don was instrumental in the development of proton-proton colliders, while Bruno and Gersh spearheaded the development of electron-positron colliders. In this brief review of the history, I will sketch the development of the concepts, the experiments, and the technological developments which made possible the development of colliders. It may look as if the emphasis is on theoretical concepts, but that is really not the case, for in this field -- the physics of beams -- the theory and experiment go hand in hand; theoretical understanding and advances are almost always motivated by the need to explain experimental results or the desire to construct better experimental devices.

  5. Transdisciplinary product development

    Directory of Open Access Journals (Sweden)

    Tomaž Savšek

    2015-12-01

    Full Text Available Research Question (RQ: How can transdisciplinary approach increase the product development process in future industry? Purpose: The aim of the research is to develop a model of an effective product development in the automotive industry based on the transdisciplinary approach. Method: We used a qualitative research approach in order to develop a theoretical framework of transdisciplinarity. The framework comprises the concurrent engineering and experts from different disciplines. The framework was represented by a mathematical model which based on stochastic dynamic programming. Results: We developed a theoretical frameworkand a practical case of transdisciplinary product development in the automotive industry. We presented a mathematical model and information environment which supports such a model. Organization: The findings of the research will provide higher productivity, lower operating costs, change in personnel structure, higher added value, lower sales costs, lower administration costs, reduction in growth of expenses, and lower costs of work equipment. Society: The research impact on higher customer’s satisfaction, increased flexibility of operations, better quality of information, improved control of sources, less waste materials and less pollution, improved planning process, more favourable consideration of employees , improved portfolio management, and better corporate presentation of company. Originality: Transdisciplinary framework combines methods of concurrent engineering and interdisciplinary approach in a process of product development. The development of such a framework is a complete novelty and represents an original approach to product development, which will be particularly suitable for the smart factories of the future. Transdisciplinary framework was transformed in to a mathematical model based on stochastic dynamic programming. Model is supported by the existing information warehouse and represents a potential for

  6. Developing students’ entrepreneurial spirit

    Directory of Open Access Journals (Sweden)

    Grădinaru, E.

    2012-01-01

    Full Text Available This paper contains a research study about the necessity to develop the entrepreneurial spirit in universities and how students could be involved in such initiatives. A qualitative research based on three focus groups was conducted, having as main objective to identify students’ opinions regarding the initiative to develop an on-line magazine for students and young people. The results reveal that students prefer the online media to the traditional ones and the pilot numbers of the magazine received good appreciations. A business plan for the future development of the magazine is also presented.

  7. Beginning Nokia Apps Development

    CERN Document Server

    Rischpater, Ray

    2010-01-01

    While media buzz regularly circulates around iPhone and Android, Nokia still leads the pack in terms of world market share. Symbian, for instance, remains the most widely used mobile operating system. With Nokia's open development platform, the opportunities available for mobile developers to target this vastly popular operating system are abundant and clear. * Use Qt to target both platforms: Symbian, the most widely used mobile operating system in the world, as well as MeeGo, the Intel/Nokia platform for mobile devices. * Develop HTML5 applications for both Symbian and MeeGo platforms that w

  8. Materials development for TESOL

    CERN Document Server

    Mishan, Freda

    2015-01-01

    Materials development has become much more important in the field of TESOL in the last twenty years: modules on materials development are now commonplace on MA TESOL courses around the world. The overall aim of the book is to introduce readers to a wide range of theoretical and practical issues in materials development to enable them to make informed and principled choices in the selection, evaluation, adaptation and production of materials. The book aims to show how these choices need to be informed by an awareness of culture, context and purpose.

  9. Development without a metropolis

    DEFF Research Database (Denmark)

    Monsson, Christian Kjær

    2014-01-01

    focusing on the management capabilities of a broad set of regional companies rather than pursuing industry-specific ‘smart’ specialisation strategies. These initiatives can include alternative models for learning and knowledge development based on shared challenges rather than industrial relatedness...... to the universal advice replete in some types of place-based development guidelines and literature. The paper consequently formulates propositions about beneficial practices for the development of non-metropolitan territories. The essence of these is that non-metropolitan regions can benefit from initiatives...

  10. Human pancreas development.

    Science.gov (United States)

    Jennings, Rachel E; Berry, Andrew A; Strutt, James P; Gerrard, David T; Hanley, Neil A

    2015-09-15

    A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.

  11. Agile software development

    CERN Document Server

    Stober, Thomas

    2009-01-01

    Software Development is moving towards a more agile and more flexible approach. It turns out that the traditional 'waterfall' model is not supportive in an environment where technical, financial and strategic constraints are changing almost every day. But what is agility? What are today's major approaches? And especially: What is the impact of agile development principles on the development teams, on project management and on software architects? How can large enterprises become more agile and improve their business processes, which have been existing since many, many years? What are the limit

  12. Developing Cultural Awareness

    OpenAIRE

    2005-01-01

    This paper aims at emphasizing the issue of teaching of culture in foreign language teaching.  In this respect, the reasons of teaching culture in foreign language classes are focused on initially.  So, the justifications of teaching culture are considered and explained and by the help of a dialogue.  Right after this, ways of developing cultural awareness is taken into account.  At this step, types of courses to develop cultural awareness are dealt with.  Developing cultural awareness in cla...

  13. Strategic port development

    DEFF Research Database (Denmark)

    Olesen, Peter Bjerg; Dukovska-Popovska, Iskra; Steger-Jensen, Kenn;

    2012-01-01

    This paper proposes a framework for strategic development of a port’s collaboration with its hinterland. The framework is based on literature relevant to port development and undertakes market perspective by considering import/export data relevant for the region of interest. The series of steps...... proposed in the framework, provide ports with a systematic approach in finding possibilities for new business ventures and increasing integration with the hinterland. The framework is generic in its approach. A case study illustrates possible usage of the framework in terms of hinterland development....

  14. Textile technology development

    Science.gov (United States)

    Shah, Bharat M.

    1995-01-01

    The objectives of this report were to evaluate and select resin systems for Resin Transfer Molding (RTM) and Powder Towpreg Material, to develop and evaluate advanced textile processes by comparing 2-D and 3-D braiding for fuselage frame applications and develop window belt and side panel structural design concepts, to evaluate textile material properties, and to develop low cost manufacturing and tooling processes for the automated manufacturing of fuselage primary structures. This research was in support of the NASA and Langley Research Center (LaRc) Advanced Composite Structural Concepts and Materials Technologies for Primary Aircraft Structures program.

  15. Speakeasy software development

    Science.gov (United States)

    Baskinger, Patricia J.; Ozarow, Larry; Chruscicki, Mary C.

    1993-08-01

    The Speakeasy Software Development Project had three primary objectives. The first objective was to perform Independent Verification and Validation (IV & V) of the software and documentation associated with the signal processor being developed by Hazeltine and TRW under the Speakeasy program. The IV & V task also included an analysis and assessment of the ability of the signal processor software to provide LPI communications functions. The second objective was to assist in the enhancement and modification of an existing Rome Lab signal processor workstation. Finally, TASC developed project management support tools and provided program management support to the Speakeasy Program Office.

  16. Piezoelectric Accelerometers Development

    DEFF Research Database (Denmark)

    Liu, Bin; Bang, Lisbet Fogh

    1999-01-01

    The paper describes the development of piezoelectric accelerometers using Finite Element (FE) approach. Brüel & Kjær Accelerometer Type 8325 is chosen as an example to illustrate the advanced accelerometer development procedure. The deviation between simulated results and measured results of Type...... 8325 are below 6%. It is proved that the specifications of the accelerometer can be effectively predicted using the FE method, especially when modifications of the accelerometer are required. The development process of piezoelectric accelerometers in Brüel & Kjær is becoming more efficient...

  17. Piezoelectric accelerometeres development

    DEFF Research Database (Denmark)

    Liu, Bin

    1999-01-01

    The paper describes the development of piezoelectric accelerometers using Finite Element (FE) approach. Brüel & Kjær Accelerometer Type 8325 is chosen as an example to illustrate the advanced accelerometer development procedure. The deviation between simulated results and measured results of Type...... 8325 are below 6%. It is proved that the specifications of the accelerometer can be effectively predicted using the FE method, especially when modifications of the accelerometer are required. The development process of piezoelectric accelerometers in Brüel & Kjær is becoming more efficient....

  18. JBoss AS 7 development

    CERN Document Server

    Marchioni, Francesco

    2013-01-01

    This book will kick-start your productivity and help you to master JBoss AS development. The author's experience with JBoss enables him to share insights on JBoss AS development in a clear and friendly way. By the end of the book, you will have the confidence to apply all the newest programming techniques to your JBoss applications.If you are a Java architect or developer who wants to get the most out of the latest release of the JBoss application server, then this book is for you. You are not expected to have accumulated experience on the application server though you must know the basic conc

  19. Beam Instrument Development System

    Energy Technology Data Exchange (ETDEWEB)

    2016-01-08

    Beam Instrumentation Development System (BIDS) is a collection of common support libraries and modules developed during a series of Low-Level Radio Frequency (LLRF) control and timing/synchronization projects. BIDS includes a collection of Hardware Description Language (HDL) libraries and software libraries. The BIDS can be used for the development of any FPGA-based system, such as LLRF controllers. HDL code in this library is generic and supports common Digital Signal Processing (DSP) functions, FPGA-specific drivers (high-speed serial link wrappers, clock generation, etc.), ADC/DAC drivers, Ethernet MAC implementation, etc.

  20. Developing systems engineers

    CSIR Research Space (South Africa)

    Goncalves, D

    2008-07-01

    Full Text Available and care of a patient. In medicine this information approach has yielded inadequate results and there has been a shift towards problem-based learning (PBL). PBL learning is a specific methodology developed by Barrows [1] and not simply solving problems... at the end of the chapter. The purpose of PBL has been to integrate knowledge and to develop problem-solving skills. PBL could also be used to develop SE skills. But there is a need for balance between PBL and the information approach. The information...

  1. [Mitochondrial and oocyte development].

    Science.gov (United States)

    Deng, Wei-Ping; Ren, Zhao-Rui

    2007-12-01

    Oocyte development and maturation is a complicated process. The nuclear maturation and cytoplasmic maturation must synchronize which can ensure normal oocyte fertilization and following development. Mitochondrial is the most important cellular organell in cytoplasm, and the variation of its distribution during oocyte maturation, the capacity of OXPHOS generating ATP as well as the content or copy number or transcription level of mitochondrial DNA play an important role in oocyte development and maturation. Therefore, the studies on the variation of mitochondrial distribution, function and mitochondrial DNA could enhance our understanding of the physiology of reproduction and provide new insight to solve the difficulties of assisted reproduction as well as cloning embryo technology.

  2. Industrialized Information Systems Development

    DEFF Research Database (Denmark)

    Havn, Erling; Bansler, Jørgen P.

    1996-01-01

    with such generic products, instead of custom made software. We discuss how the move away from traditional in-house development and the increasing use of generic software is likely to transform IS development in the near future. We conclude that these developments will make new demands on the information systems......The production of application software is rapidly being industrialized. Computer manufacturers and software houses produce a rapidly growing number of generic software applications and systems, and more and more user companies choose to build their computer-based information systems...

  3. Engrailed and tectum development.

    Science.gov (United States)

    Omi, Minoru; Nakamura, Harukazu

    2015-02-01

    The optic tectum is a visual center of nonmammalian vertebrates derived from the mesencephalon. In this review, function of Engrailed (En) in tectum development is reviewed. En plays crucial roles at three steps of tectum development. First, Engrailed is expressed in the mesencephalon and the metencephalon and essential for the regionalization of the mesencephalon. En is expressed in a gradient of caudal-to-rostral in the tectum primordial, and regulates the rostrocaudal polarity of the tectum. In the advanced stage of tectum development, En is expressed in a lamina-specific manner and it is suggested that En regulates cell migration in the tectal laminar formation.

  4. Participation for Development

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; De La Harpe, Retha; Korpela, Mikko

    2014-01-01

    Information and Communication Technology (ICT) is more and more promoted as a driver and facilitator of economic growth and development in low and middle income countries. ICT for Development (ICT4D) though has mixed successes. Sustainability of solutions and usability respectively usefulness...... is rare. The workshop aims at bringing together the PD researchers working with under-privileged communities and attracting researchers from the ICT4D communities to the PD conference. The goal is to share experiences and start a discussion on how participation, ICT and development might relate....

  5. CNS development: an overview

    Science.gov (United States)

    Nowakowski, R. S.; Hayes, N. L.

    1999-01-01

    The basic principles of the development of the central nervous system (CNS) are reviewed, and their implications for both normal and abnormal development of the brain are discussed. The goals of this review are (a) to provide a set of concepts to aid in understanding the variety of complex processes that occur during CNS development, (b) to illustrate how these concepts contribute to our knowledge of the normal anatomy of the adult brain, and (c) to provide a basis for understanding how modifications of normal developmental processes by traumatic injury, by environmental or experiential influences, or by genetic variations may lead to modifications in the resultant structure and function of the adult CNS.

  6. Professional mobile application development

    CERN Document Server

    McWherter, Jeff

    2012-01-01

    Create applications for all major smartphone platforms Creating applications for the myriad versions and varieties of mobile phone platforms on the market can be daunting to even the most seasoned developer. This authoritative guide is written in such as way that it takes your existing skills and experience and uses that background as a solid foundation for developing applications that cross over between platforms, thereby freeing you from having to learn a new platform from scratch each time. Concise explanations walk you through the tools and patterns for developing for all the mobile platfo

  7. Tracking Your Development

    CERN Document Server

    Hennum, Kelly M

    2011-01-01

    This book provides you with the means to set development goals and to track your progress on achieving them. It can help you efficiently gather and make sense of information about your progress and avoid common pitfalls that can block your development. Tracking your development can be captures in a few steps: articulating your goal, creating an action plan, gathering information about your behavior, indentifying barriers and support, and revising your action plan. Taking these steps will greatly increase the likelihood of achieving your goals.

  8. Shanghai's Development Zones

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    @@ Since the early 1980s,development zones began appearing in China.Their Success largely stems from the preferential policies they offer and the safe investment environment they work hard to create.As zones have personalities themselves,it is essential to look beyond the pamphlets and published information and get down to the nittygritty.Shanghai has more State designated Economic and Technology Development Zones than any other city in China.In the following article,we have chosen development zones located around Shanghai and conducted a comparison.

  9. Leap Motion development essentials

    CERN Document Server

    Spiegelmock, Mischa

    2013-01-01

    This book is a fast-paced guide with practical examples that aims to help you understand and master the Leap Motion SDK.This book is for developers who are either involved in game development or who are looking to utilize Leap Motion technology in order to create brand new user interaction experiences to distinguish their products from the mass market. You should be comfortable with high-level languages and object-oriented development concepts in order to get the most out of this book.

  10. Splunk developer's guide

    CERN Document Server

    Smith, Kyle

    2015-01-01

    If you are a Splunk user and want to enter the wonderful world of Splunk application development, then this book is for you. Some experience with Splunk, writing searches, and designing basic dashboards is expected.

  11. Catalyzing RE Project Development

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Kate; Elgqvist, Emma; Walker, Andy; Cutler, Dylan; Olis, Dan; DiOrio, Nick; Simpkins, Travis

    2016-09-01

    This poster details how screenings done with REopt - NREL's software modeling platform for energy systems integration and optimization - are helping to catalyze the development of hundreds of megawatts of renewable energy.

  12. Organizational Development and Evaluation.

    Science.gov (United States)

    Patton, Michael Quinn

    1999-01-01

    Explores some opportunities open to evaluators as practitioners of organizational development and the advantages and competencies evaluators can bring to such initiatives. Presents eight examples of such opportunities. (SLD)

  13. Infant - newborn development

    Science.gov (United States)

    ... feeding are good. This is due to immature abdominal muscles used for pushing and does not need to ... holding, rocking, or cuddling. The infant's growth or development does not appear normal. Your infant seems to ...

  14. Consulting in Collection Development.

    Science.gov (United States)

    Ash, Lee

    1980-01-01

    Considers the role of the consultant in the areas of library collection development and weeding, and offers suggestions on determining the need for a consultant, obtaining one, and what to do when the consultant arrives. (FM)

  15. Pharmaceutical Industry Develops Steadily

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ With the development of the economy, the growth of the total population, the growing proportion of older citizens, and the increasing awareness of people's health care,the pharmaceutical market in China has seen a sustained and rapid expansion.

  16. Ocean Technology Development Tank

    Data.gov (United States)

    Federal Laboratory Consortium — The new SWFSC laboratory in La Jolla incorporates a large sea- and fresh-water Ocean Technology Development Tank. This world-class facility expands NOAA's ability to...

  17. Element-ary Development.

    Science.gov (United States)

    Schamp, Homer W., Jr.

    1989-01-01

    Describes the historic development of the periodic table from the four-element theory to the Lavoisier's table. Presents a table listing the old and new names of chemicals and the Lavoisier's table of elements. Lists two references. (YP)

  18. Personal professional development

    CSIR Research Space (South Africa)

    Rao, S

    2008-10-01

    Full Text Available Three workshop sessions on personal professional development were held during the Third IUPAP Women in Physics Conference. These were designed to teach participants about planning for career success, "survival skills," negotiation, and ways...

  19. EFFECTIVE PARTICIPATORY DEVELOPMENT

    African Journals Online (AJOL)

    This article focuses on the role of language in development communication. This is .... prove life, while the second attempts to help people with the skills and knowledge needed ..... not speak the local languages expressed their desire to do so.

  20. Game development with Swift

    CERN Document Server

    Haney, Stephen

    2015-01-01

    If you wish to create and publish fun iOS games using Swift, then this book is for you. You should be familiar with basic programming concepts. However, no prior game development or Apple ecosystem experience is required.

  1. Cascade Distillation System Development

    Science.gov (United States)

    Callahan, Michael R.; Sargushingh, Miriam; Shull, Sarah

    2014-01-01

    NASA's Advanced Exploration Systems (AES) Life Support System (LSS) Project is chartered with de-veloping advanced life support systems that will ena-ble NASA human exploration beyond low Earth orbit (LEO). The goal of AES is to increase the affordabil-ity of long-duration life support missions, and to re-duce the risk associated with integrating and infusing new enabling technologies required to ensure mission success. Because of the robust nature of distillation systems, the AES LSS Project is pursuing develop-ment of the Cascade Distillation Subsystem (CDS) as part of its technology portfolio. Currently, the system is being developed into a flight forward Generation 2.0 design.

  2. Land management and development

    DEFF Research Database (Denmark)

    Enemark, Stig

    2006-01-01

    Land management is the process by which the resources of land are put into good effect. Land management encompasses all activities associated with the management of land that are required to achieve sustainable development. The concept of land includes properties and natural resources and thereby...... encompasses the total natural and built environment. Land Administration Systems (LAS) are institutional frameworks complicated by the tasks they must perform, by national cultural, political and judicial settings, and by technology. This paper facilitates an overall understanding of the land management......, responsibilities, restrictions and risks in relation to land in support of sustainable development. The model is designed for developed economies but allows incremental adoption of the model by countries at transitional stages of economic development. The model reflects drivers of globalisation and technology...

  3. TOURISM AND SUSTAINABLE DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    Gina Ionela Butnaru

    2014-06-01

    Full Text Available Tourism and sustainable development are the subject of many initiatives and public or private debates in Romania. The main problem to which these initiatives try to find an answer is mostly related to the income generation for the local communities by using rationally and efficiently the local potential, in agreement with the economic, social, natural, and cultural factors. Consequently, some measures should be taken, and the tourist sector as a whole needs all the methods of sustainable development: new technologies, change of social behaviour, change of environmental legislation, methods of environmental management, better planning and development of control procedures. In this article, we presented a model of tourism development which should be applied in all the regions of great tourist attraction, and we realised a synthesis of the socio-economic advantages of sustainable tourism.

  4. Energy and Development

    Directory of Open Access Journals (Sweden)

    Gilles Carbonnier

    2012-03-01

    Full Text Available Published by Palgrave MacmillanThis chapter introduces the thematic dossier of International Development Policy on the intimate relationship between energy and development. The authors discuss the centrality of fossil fuels in the economic growth of the Western world since the nineteenth century and the key role of oil in the twentieth century and question the future of this development model in the face of geological and climatic constraints. They examine the gaps and misunderstandings that separate social sciences and natural sciences as well as recent attempts to establish interdisciplinary dialogue around ecological economics and industrial ecology. The authors then analyse what is at stake for developing countries, inequalities in access to energy resources, the failure of the global governance system to deal with mounting tensions associated with the depletion of oil and the environmental consequences of an ever increasing consumption of non-renewable resources.

  5. Physics for development

    Science.gov (United States)

    Chetty, Nithaya; Connell, Simon; Bawa, Ahmed C.

    2007-11-01

    South Africa has recognized the importance of science in the development of its society, in moving away from its apartheid past and striving to eradicate poverty. Opportunities abound in its growing programme of physics research.

  6. Advanced Hydrogen Turbine Development

    Energy Technology Data Exchange (ETDEWEB)

    Marra, John [Siemens Energy, Inc., Orlando, FL (United States)

    2015-09-30

    Under the sponsorship of the U.S. Department of Energy (DOE) National Energy Technology Laboratories, Siemens has completed the Advanced Hydrogen Turbine Development Program to develop an advanced gas turbine for incorporation into future coal-based Integrated Gasification Combined Cycle (IGCC) plants. All the scheduled DOE Milestones were completed and significant technical progress was made in the development of new technologies and concepts. Advanced computer simulations and modeling, as well as subscale, full scale laboratory, rig and engine testing were utilized to evaluate and select concepts for further development. Program Requirements of: A 3 to 5 percentage point improvement in overall plant combined cycle efficiency when compared to the reference baseline plant; 20 to 30 percent reduction in overall plant capital cost when compared to the reference baseline plant; and NOx emissions of 2 PPM out of the stack. were all met. The program was completed on schedule and within the allotted budget

  7. Developing Effective Performance Measures

    Science.gov (United States)

    2014-10-14

    University When Performance Measurement Goes Bad Laziness Vanity Narcissism Too Many Pettiness Inanity 52 Developing Effective...Kasunic, October 14, 2014 © 2014 Carnegie Mellon University Narcissism Measuring performance from the organization’s point of view, rather than from

  8. WORLDVIEWS ON DEVELOPMENT

    African Journals Online (AJOL)

    development of society generally, with particular reference to Sub-. Saharan Africa and ... Other failures to attempt to solve perceived problems involve what social ... Such irrational behaviour often arises when each of us individually is torn.

  9. NiGERIAN DEVELOPMENT '

    African Journals Online (AJOL)

    enabling environment for SMEs to thrive Will result in development. This paper .... the study mainly from relevant books, journals, Internet and newspapers. ..... 0 India — The SME sector in India has 3.3 million units and contributes around 40.

  10. Innovating for Rural Development

    DEFF Research Database (Denmark)

    Christensen, Dorthe

    is that policies, agricultural research and extension should pay attention to these financial structural aspects, since they regulate the extent of ‘public good extension services’ like rural development services and ‘innovation intermediation’ in Danish agricultural extension agencies. The capacity differs among...... the individual agencies and among individual agents. There are agencies that financially invest in rural development service, including in innovation intermediation. On the other hand, there are agencies where the presence of rural development service is merely as a formal structure, possibly to signal...... interactions, by exploring the perspective of the participants; and the paper also seeks to understand possible constraining or supportive extension aspects at play. Paper 3 examines how the apparent change effort: ‘rural development service’ is reflected in the management strategies of individual agricultural...

  11. Qingjiang River Developer

    Institute of Scientific and Technical Information of China (English)

    2003-01-01

    THE 400-kilometer Qingjiang River, second tributary of the Yangtze River in Hubei Province, has a drainage area of 17,000 square kilometers. Its advantageous natural conditions have made it a key water power development project.

  12. PQ Development in Europe

    Institute of Scientific and Technical Information of China (English)

    Angelo Baggini

    2013-01-01

    This paper aims to give an overview on main PQ development in Europe. It focuses basically on recent legislative, regulatory, standardization, voltage quality monitoring and education initiatives, summarizing the latest outcomes.

  13. Poverty and development

    Directory of Open Access Journals (Sweden)

    Néstor Juan Sanabria Landazábal

    2006-07-01

    Full Text Available In this essay there is argued that the notions ofpoverty, development, quality of life and, in general, all the concepts, variables and indicators used in the explanations and theories on this type, are different points of view from the observers' interests,of the same and only social phenomenon. Therefore,there are multiple works on poverty and development. However, an approximation from the perspective of complexity must bear in mind that the development may refer to the social structure as a whole, and to the actions that modify context of the system, just when it has been ordered through the science in order to explain the reality. Therefore,there is a clase relation between poverty and development. These are different ways to see the same phenomenon, which allow us to think about the life quality from a global sense.

  14. RISK ANALYSIS DEVELOPED MODEL

    Directory of Open Access Journals (Sweden)

    Georgiana Cristina NUKINA

    2012-07-01

    Full Text Available Through Risk analysis developed model deciding whether control measures suitable for implementation. However, the analysis determines whether the benefits of a data control options cost more than the implementation.

  15. Urban Quality Development & Management

    DEFF Research Database (Denmark)

    Lehmann, Martin; Fryd, Ole

    2008-01-01

    : Urban quality development and management is dependent on human resource development, institutionalised networks and confident exchange of knowledge, and must identify and incorporate multiple environmental, social, economic and cultural aspects. The authors find that at the core of innovative societies......, an interlinkage exists between practice (business, civil society, governance) and theory (research, education). The case illustrates how a new curriculum takes time to develop and implement and how it relies on confidence and trust between partners, in this case cities and universities, before being able to plant...... the seed for a sustainable response to the needs of city administrations. University consortia may be particularly useful as providers of a broad framework and an enabling setting in which diffusion of innovation can occur. Practical implications: The article presents a successful approach to developing...

  16. LIDAR Research & Development Lab

    Data.gov (United States)

    Federal Laboratory Consortium — The LIDAR Research and Development labs are used to investigate and improve LIDAR components such as laser sources, optical signal detectors and optical filters. The...

  17. Fiber Optics Instrumentation Development

    Science.gov (United States)

    Chan, Patrick Hon Man; Parker, Allen R., Jr.; Richards, W. Lance

    2010-01-01

    This is a general presentation of fiber optics instrumentation development work being conducted at NASA Dryden for the past 10 years and recent achievements in the field of fiber optics strain sensors.

  18. Leadership for product development

    DEFF Research Database (Denmark)

    Martensen, Anne; Dahlgaard, Jens Jørn

    1998-01-01

    This paper discusses how the research within product development can be integrated with the research within quality management and business excellence, to achive what creates excellent quality in the innovation process. Elements and viewpoints can be linked together in a systematic and holistic way...... by applying the European Business Excellence Model to product development. The innovation process differs in several fields from other processes in the company. For instance, research and development are influenced by a high level of uncertainty and experimentation, and the job is often characterized...... the criterion "leadership" comprise when the focus is on R and D? Eight new criterion parts will be discussed. It is believed, that the recommended approach will improve leadership for product development. Udgivelsesdato: JUL...

  19. Developing Software Simulations

    Directory of Open Access Journals (Sweden)

    Tom Hall

    2007-06-01

    Full Text Available Programs in education and business often require learners to develop and demonstrate competence in specified areas and then be able to effectively apply this knowledge. One method to aid in developing a skill set in these areas is through the use of software simulations. These simulations can be used for learner demonstrations of competencies in a specified course as well as a review of the basic skills at the beginning of subsequent courses. The first section of this paper discusses ToolBook, the software used to develop our software simulations. The second section discusses the process of developing software simulations. The third part discusses how we have used software simulations to assess student knowledge of research design by providing simulations that allow the student to practice using SPSS and Excel.

  20. SOCIOECONOMIC DEVELOPMENT INEQUALITIES AMONG ...

    African Journals Online (AJOL)

    Osondu

    Ethiopian Journal of Environmental Studies and Management Vol. 6 No.3 2013. Department .... distance to the nearest highway, car ownership, population .... Umoren, V.E. (2008). Impact of Road. Transport on Socio-Economic Development in.

  1. Learning Spring application development

    CERN Document Server

    Soni, Ravi Kant

    2015-01-01

    This book is intended for those who are interested in learning the core features of the Spring Framework. Prior knowledge of Java programming and web development concepts with basic XML knowledge is expected.

  2. Developing Bigraphical Languages

    DEFF Research Database (Denmark)

    Damgaard, Troels Christoffer

    , a prototype tool for experimenting with bigraphical reactive systems. In a second line of work, we study bigraphical reactive systems as a vehicle for developing a language to model biochemical reactions at the level of cells and proteins. We discuss and isolate B,R-calculi, a family of bigraphical reactive......In this dissertation, we study bigraphical languages—languages based on the theory for bigraphs and bigraphical reactive systems developed by Milner and coworkers. We begin by examining algebraic theory for binding bigraphs. We give a term language for binding bigraphs and develop a complete...... systems that we deem sufficient for the language. We develop a self-contained presentation of the syntax and operational semantics for B,R-calculi that exploits the restrictions we have made on the family. We also treat how one may extend certain bigraphical reaction rules to include negative contextual...

  3. Participation for Development

    DEFF Research Database (Denmark)

    Dittrich, Yvonne; De La Harpe, Retha; Korpela, Mikko

    2014-01-01

    Information and Communication Technology (ICT) is more and more promoted as a driver and facilitator of economic growth and development in low and middle income countries. ICT for Development (ICT4D) though has mixed successes. Sustainability of solutions and usability respectively usefulness...... for the intended beneficiaries have been reported as causes. Participatory approaches to development have been proposed to address these causes. Participatory Design (PD) seems like a perfect fit. However, at the Participatory Design Conferences, research that addresses PD in low and middle income countries...... is rare. The workshop aims at bringing together the PD researchers working with under-privileged communities and attracting researchers from the ICT4D communities to the PD conference. The goal is to share experiences and start a discussion on how participation, ICT and development might relate....

  4. Economic Development of Nigeria

    African Journals Online (AJOL)

    User

    ... society from subsistence economy to urban – industrialization, to the sustained raise in .... of Human Development Index (HDI) attempt to rank all countries in a scale ... variables include population size, education as measured by school.

  5. Women's Career Development Patterns.

    Science.gov (United States)

    Schreiber, Pamela J.

    1998-01-01

    Women's career development is characterized by balance of work and family, career interruptions, and diverse career paths. Alternative work arrangements such as flexible schedules, telecommuting, and entrepreneurial opportunities may offer women more options for work. (SK)

  6. Madagascar Conservation & Development

    African Journals Online (AJOL)

    www.journalmcd.com

    energy shock had passed, liberalism was booming and the 'environmental ..... CAR primary forest, or 1.2 Mha, will be lost during the coming two decades ... tion for the Clean Development Mechanism, Forest and Climate. Change Working ...

  7. Doing Systems Development

    DEFF Research Database (Denmark)

    Koch, Christian; Mathiasen, John Bang

    2014-01-01

    Systems development of wind turbine control is competitive with respect to innovation, time and cost. So how can learning possibly occur under such circumstances? Dewey’s pragmatist approach to learning is adopted, emphasising reciprocity between the systems developer’s individual experience...... and the sociotechnical practice. The framework involves the concepts of sociotechnical practice, anchoring of indeterminate situation, and strip of doings towards determinate situation. An ethnographic study was made of four cases of systems development and learning do occur in the cases, enabled by converging anchoring...... of the indeterminate situation and the systems developers different experience. However, an extreme case reveals initiated learning processes and that the interchanges between materiality of the artefacts and systems developers block the learning processes due to a customer with imprecise demands and unclear system...

  8. Logistics innovation development

    DEFF Research Database (Denmark)

    Pedrosa, Alex; Blazevic, Vera; Jasmand, Claudia

    2015-01-01

    illustrate that boundary-spanning employees are well advised to concentrate on either deepening or broadening their customer knowledge in a single stage of the logistics innovation development process but switch between these two knowledge acquisition approaches from stage-to-stage to leverage customer...... about customers for the development of innovations. Design/methodology/approach — Qualitative research based on multiple semi-structured interviews with boundary-spanning employees of six logistics service providers was conducted to explore the deepening and broadening of customer knowledge during...... knowledge throughout the logistics innovation development process. Yet, the specific sequence depends on the type of innovation developed (customized versus standardized). Customer knowledge tends to be deepened in one-on-one interactions, while knowledge tends to be broadened in interactions with numerous...

  9. Growth and Development

    Science.gov (United States)

    ... Reading Is Your Child Too Busy? Helping Your Child Adjust to Preschool School Lunches Kids and Food: 10 Tips for Parents Healthy Habits for TV, Video Games, and the Internet Growth & Development What should you expect as your child grows? ...

  10. Partnerships for Development

    DEFF Research Database (Denmark)

    Christensen, David; Drysdale, David; Hansen, Kenneth

    2014-01-01

    Municipal solid waste (MSW) management systems of many developing countries are commonly constrained by factors such as limited financial resources and poor governance, making it a difficult proposition to break with complex, entrenched and unsustainable technologies and systems. This paper...

  11. Developable hyperspaces are metrizable

    Directory of Open Access Journals (Sweden)

    L'Ubica Holá

    2003-10-01

    Full Text Available Developability of hyperspace topologies (locally finite, (bounded Vietoris, Fell, respectively on the nonempty closed sets is characterized. Submetrizability and having a Gδ-diagonal in the hyperspace setting is also discussed.

  12. Developments in Scintillometry

    NARCIS (Netherlands)

    Moene, A.F.; Beyrich, F.; Hartogensis, O.K.

    2009-01-01

    Thirty scientists from five nations discussed developments in the growing field of scintillometry—the study of wave propagation in the atmospheric surface layer that can be used to measure and decipher low-level turbulence.

  13. Developing Software Simulations

    Directory of Open Access Journals (Sweden)

    Tom Hall

    2007-06-01

    Full Text Available Programs in education and business often require learners to develop and demonstrate competence in specified areas and then be able to effectively apply this knowledge. One method to aid in developing a skill set in these areas is through the use of software simulations. These simulations can be used for learner demonstrations of competencies in a specified course as well as a review of the basic skills at the beginning of subsequent courses. The first section of this paper discusses ToolBook, the software used to develop our software simulations. The second section discusses the process of developing software simulations. The third part discusses how we have used software simulations to assess student knowledge of research design by providing simulations that allow the student to practice using SPSS and Excel.

  14. SUSTAINABLE DEVELOPMENT PARADIGM - SYNOPSIS

    Directory of Open Access Journals (Sweden)

    Constantinescu Andreea

    2014-07-01

    Full Text Available Even if sustainable development is a concept that gained quite recently its scientific prestige, through contribution of researchers its content has upgraded to a high degree of conceptual luggage and, through contribution from governance representatives, has gained an impressive good-practice background. Allowing the use of different methodological premises and conceptual tools, sustainable development paradigm is equipped with all the elements that would allow the opening of new horizons of knowledge. Based on the facility which can operate the concept of sustainable development, the European Union aims to develop both a more competitive economy based on environmental protection as well as a new governance of economic policy. This on one hand demonstrates the sustainable development ability to irradiate creativity towards the establishment of interdisciplinary bridges and on the other hand explains the growing interest of researchers interested in the problem of analyzing in detail this fruitful concept. Launched first as a theoretical framework to serve justify actions responsible for weighting economic growth, the concept of Sustainable Development has quickly become a topic of ethical debate circumscribed to the area of perfectibility of human nature to the necessity registry. In this regard, the philosophical content of this paradigm could not remain outside researchers concerns, who want to provide both policy makers and the general public a wide range of evidence to demonstrate the viability of this paradigm. Academia waits until maximization of the contribution of governance to achieve sustainable economic development, which consists in conjunction of this upward path with the momentum given by public policy sync, perfectly adapted for globalization era and all crises to come. However, because this concept based its structure and composition on three pillars, equally important economy, society and environment any attempt to strengthen

  15. Global software development

    DEFF Research Database (Denmark)

    Matthiesen, Stina

    2016-01-01

    This overview presents the mid stages of my doctoral research-based on ethnographic work conducted in IT companies in India and in Denmark-on collaborative work within global software development (GSD). In the following I briefly introduce how this research seeks to spark a debate in CSCW...... by challenging contemporary ideals about software development outsourcing through the exploration of the multiplicities and asymmetric dynamics inherent in the collaborative work of GSD....

  16. Develop your leadership skills

    CERN Document Server

    Adair, John

    2016-01-01

    "Develop Your Leadership Skills "is John Adair s most accessible title on leadership. Full of exercises and checklists, it can help boost confidence levels and guide and inspire anyone on their journey to becoming a leader of excellence. Acknowledged as a world expert, John Adair offers stimulating insights into recognizing and developing individual leadership qualities, acquiring personal authority, and mastering core leadership functions such as planning, communicating and motivating. The new edition includes summary points for each chapter.

  17. Foresighting for Inclusive Development

    DEFF Research Database (Denmark)

    Dahl Andersen, Allan; Andersen, Per Dannemand

    We propose that foresight can contribute to inclusive development by making innovation policy processes more inclusive, which in turn makes innovation systems more inclusive. Processes of developing future-oriented innovation policies are often unsuccessful and rarely inclusive. We conceptualize ...... and processes in two foresight cases in two emerging economies - Brazil and South Korea. Although the research is exploratory and the results tentative, the empirical studies support our main propositions....

  18. Knowledge Development in Internship

    DEFF Research Database (Denmark)

    Dau, Susanne

    2015-01-01

    The purpose of the chapter is to shed light on how these challenges and tendencies affect students’´ access to tacit and explicit knowledge and the professions’ knowledge development. To address these challenges, the chapter examines the question: How might periods of internship, offering different...... kinds of access to tacit and explicit knowledge by apprenticeship and reflection, have consequences for both students’ learning and the professions’ knowledge development?...

  19. Remediation Technology Collaboration Development

    Science.gov (United States)

    Mahoney, John; Olsen, Wade

    2010-01-01

    This slide presentation reviews programs at NASA aimed at development at Remediation Technology development for removal of environmental pollutants from NASA sites. This is challenging because there are many sites with different environments, and various jurisdictions and regulations. There are also multiple contaminants. There must be different approaches based on location and type of contamination. There are other challenges: such as costs, increased need for resources and the amount of resources available, and a regulatory environment that is increasing.

  20. Developing a training package.

    Science.gov (United States)

    Minogue, Virginia; Donskoy, Anne-Laure

    2017-06-12

    Purpose The purpose of this paper is to outline the development of a training package for service users and carers with an interest in NHS health and social care research. It demonstrates how the developers used their unique experience and expertise as service users and carers to inform their work. Design/methodology/approach Service users and carers, NHS Research and Development Forum working group members, supported by health professionals, identified a need for research training that was tailored to other service user and carer needs. After reviewing existing provision and drawing on their training and support experience, they developed a training package. Sessions from the training package were piloted, which evaluated positively. In trying to achieve programme accreditation and training roll-out beyond the pilots, the group encountered several challenges. Findings The training package development group formed good working relationships and a co-production model that proved sustainable. However, challenges were difficult to overcome owing to external factors and financial constraints. Practical implications Lessons learnt by the team are useful for other service users and carer groups working with health service professionals. Training for service users and carers should be designed to meet their needs; quality and consistency are also important. The relationships between service user and carer groups, and professionals are important to understanding joint working. Recognising and addressing challenges at the outset can help develop strategies to overcome challenges and ensure project success. Originality/value The training package was developed by service users and carers for other service users and carers. Their unique health research experience underpinned the group's values and training development.

  1. Land management and development

    DEFF Research Database (Denmark)

    Enemark, Stig

    2006-01-01

    Land management is the process by which the resources of land are put into good effect. Land management encompasses all activities associated with the management of land that are required to achieve sustainable development. The concept of land includes properties and natural resources and thereby...... land related data. It is argued that development of such a model is important or even necessary for facilitating a holistic approach to the management of land as the key asset of any nation or jurisdiction....

  2. Entrepreneurship and regional development

    DEFF Research Database (Denmark)

    Müller, Sabine

    This literature review examines how entrepreneurship and regional development has been previously addressed theoretically and empirically. Regional Science and Entrepreneurship are two fields with their own distinct literature's. The question is therefore, how do these two fields talk about...... the respective other? What are the commonalities and differences? The purpose of this article is to create an analytical synthesis by combining the insights of the two literature's in order to gain a fuller understanding of the relation between entrepreneurship and regional development....

  3. World Development Report 2015

    OpenAIRE

    World Bank Group

    2014-01-01

    Every policy relies on explicit or implicit assumptions about how people make choices. Those assumptions typically rest on an idealized model of how people think, rather than an understanding of how everyday thinking actually works. This year’s World Development Report argues that a more realistic account of decision-making and behavior will make development policy more effective. The Report emphasizes what it calls 'the three marks of everyday thinking.' In everyday thinking, people use...

  4. Solar energy emplacement developer

    Science.gov (United States)

    Mortensen, Michael; Sauls, Bob

    1991-01-01

    A preliminary design was developed for a Lunar Power System (LPS) composed of photovoltaic arrays and microwave reflectors fabricated from lunar materials. The LPS will collect solar energy on the surface of the Moon, transform it into microwave energy, and beam it back to Earth where it will be converted into usable energy. The Solar Energy Emplacement Developer (SEED) proposed will use a similar sort of solar energy collection and dispersement to power the systems that will construct the LPS.

  5. Development of TOPS

    Science.gov (United States)

    Tanaka, Yoshiyuki; Tsugiishi, Shigemi

    The off-line patent and utility model information management system at Teijin Ltd. had been developed and operated since 1980. To achieve efficient business management through office automation and to get ready for easy access to electronic document delivery so-called Paperless project being developed by Japan Patent Office, the system was reviewed and new online system was constructed in 1985. The paper describes its details.

  6. A Decade Of Development

    Institute of Scientific and Technical Information of China (English)

    YU HEJUN

    2010-01-01

    @@ With the adoption of the reform and opening-up policy in the late 1970s,China ushered in a new era of modernization.But while the policies have led to the rapid development of east China,the per-capita GDP of east China is one and a half times the country's average and the region has accumulated a significant amount of capital,talent and technology,development in west China has been comparatively backward.

  7. Development of Portable Detectors

    Energy Technology Data Exchange (ETDEWEB)

    None

    2006-12-01

    The purpose of this Cooperative Research and Development Agreement (CRADA) between UT-Battelle, LLC (the “Contractor”) and Sense Holdings, Inc. (the “Participant”) was for the development of hand-held detectors with high sensitivity and selectivity for the detection of explosives, toxic industrial chemicals and materials, and other materials of interest for security applications. The two parties built a series of demonstration and prototype handheld sensors based upon micoelectromechanical systems (MEMS) with electronic readout.

  8. Steps to African Development

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    The development of Africa is vital to the world’s sustainable development.However,African countries still face key challenges in achieving the meaningful expansion of their economies.At the High-Level Symposium on China-Africa Investment Cooperation in Xiamen,southeast China’s Fujian Province,held from September 8 to 10,Chen Deming,Minister of Commerce of China,elaborates on these challenges and sees

  9. 2012 Development Effectiveness Review

    OpenAIRE

    Asian Development Bank (ADB)

    2013-01-01

    The Development Effectiveness Review 2012 Report is the sixth annual corporate performance review of the Asian Development Bank (ADB). It assesses progress in implementing Strategy 2020, ADB’s long-term strategic framework, using the performance indicators, baselines, and targets in the ADB results framework. It analyzes performance trends, identifies strengths and weaknesses, and defines corrective actions. The review takes stock of progress since 2008 and shows whether ADB met its 2012 targ...

  10. Turkmenistan; Recent Economic Developments

    OpenAIRE

    1998-01-01

    This paper reviews economic developments in Turkmenistan during 1994–97. To address the growing economic difficulties, the government announced an economic reform package for 1996, which aimed at achieving a recovery in output, sharply lowering inflation, maintaining a strong reserve position, and promoting private sector development. The reform package had mixed success. Monetary and credit policy was generally restrained until late 1996, contributing to a moderation in inflation. However,...

  11. GCS component development cycle

    Science.gov (United States)

    Rodríguez, Jose A.; Macias, Rosa; Molgo, Jordi; Guerra, Dailos; Pi, Marti

    2012-09-01

    The GTC1 is an optical-infrared 10-meter segmented mirror telescope at the ORM observatory in Canary Islands (Spain). First light was at 13/07/2007 and since them it is in the operation phase. The GTC control system (GCS) is a distributed object & component oriented system based on RT-CORBA8 and it is responsible for the management and operation of the telescope, including its instrumentation. GCS has used the Rational Unified process (RUP9) in its development. RUP is an iterative software development process framework. After analysing (use cases) and designing (UML10) any of GCS subsystems, an initial component description of its interface is obtained and from that information a component specification is written. In order to improve the code productivity, GCS has adopted the code generation to transform this component specification into the skeleton of component classes based on a software framework, called Device Component Framework. Using the GCS development tools, based on javadoc and gcc, in only one step, the component is generated, compiled and deployed to be tested for the first time through our GUI inspector. The main advantages of this approach are the following: It reduces the learning curve of new developers and the development error rate, allows a systematic use of design patterns in the development and software reuse, speeds up the deliverables of the software product and massively increase the timescale, design consistency and design quality, and eliminates the future refactoring process required for the code.

  12. Disability and global development.

    Science.gov (United States)

    Durocher, Joan; Lord, Janet; Defranco, Allison

    2012-07-01

    The United States invests billions of taxpayer dollars each year into foreign assistance programs that foster international diplomacy and development directed toward improving the quality of life for people around the world. These programs develop economies and combat poverty, promote democracy and governance, build new infrastructure, advance and protect human rights, among other development goals. The United States cannot effectively accomplish the goals of foreign assistance programs unless it undertakes measures to ensure that the programs are accessible to and inclusive of people with disabilities. The United States has been a leader in advancing the rights of people with disabilities and must continue to promote disability rights through its international development work. Overseas economic development will not be successful unless people with disabilities are included. Because of the significant number of people with disabilities in developing countries, if they are not included, the very economic growth the United States is trying to foster will be hindered. The goals of democracy and governance programs cannot be achieved without the inclusion of people with disabilities. In many countries, domestic law contains blatant discriminatory provisions for people with disabilities that undermine access to justice and full participation in society. The provisions that discriminate against people with disabilities include arbitrary exclusions in electoral codes, sweeping plenary guardianship laws with no due-process protections, discriminatory banking practices, and inaccessible court proceedings. National disability legal frameworks remain underdeveloped throughout the world.

  13. Business Development Corporation, Inc.

    Energy Technology Data Exchange (ETDEWEB)

    Jasek, S.

    1995-12-31

    Business Development Corporation, Inc., is a company specializing in opportunity seeking and business development activities in the {open_quotes}new{close_quotes} post communist Central and Eastern Europe, with particular emphasis on the Republics of Poland and Slovakia. The company currently focuses its expertise on strategic investing and business development between Central Europe and the United States of America. In Poland and Slovakia, the company specializes in developing large scale energy and environmental {open_quotes}infrastructure{close_quotes} development projects on the federal, state, and local level. In addition, the company assists large state owned industries in the transformation and privatization process. Business Development Corporation has assisted and continues to assist in projects of national importance. The staff of experts advise numerous large Polish and Slovak companies, most owned or in the process of privatization, on matters of restructuring, finance, capital structure, strategic parternships or investors, mergers, acquisitions and joint ventures with U.S. based firms. The company also assists and advises on a variety of environmental and energy matters in the public and private sector.

  14. Trilinos developers SQE guide :

    Energy Technology Data Exchange (ETDEWEB)

    Willenbring, James Michael; Heroux, Michael Allen

    2013-05-01

    The Trilinos Project is an effort to develop algorithms and enabling technologies within an object-oriented software framework for the solution of large-scale, complex multi-physics engineering and scientific problems. A new software capability is introduced into Trilinos as a package. A Trilinos package is an integral unit and, although there are exceptions such as utility packages, each package is typically developed by a small team of experts in a particular algorithms area such as algebraic preconditioners, nonlinear solvers, etc. The Trilinos Developers SQE Guide is a resource for Trilinos package developers who are working under Advanced Simulation and Computing (ASC) and are therefore subject to the ASC Software Quality Engineering Practices as described in the Sandia National Laboratories Advanced Simulation and Computing (ASC) Software Quality Plan: ASC Software Quality Engineering Practices Version 3.0 document [1]. The Trilinos Developer Policies webpage [2] contains a lot of detailed information that is essential for all Trilinos developers. The Trilinos Software Lifecycle Model [3] defines the default lifecycle model for Trilinos packages and provides a context for many of the practices listed in this document.

  15. TOURISM AND LOCAL DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    BORMA AFRODITA

    2015-04-01

    Full Text Available The paper presents a theoretical approach of the relation between tourism and local development. The research method used is based on documenting and summarizing aspects related to the importance of tourism on local development. According to data provided by the World Tourism Organization (WTO, 2014, compared to 2010, a 91% increase of the number of international tourist arrivals is forecasted in 2030, from 948 million arrivals (2010 to 1,810 million arrivals (2030. Therefore, it is no surprise that tourism is viewed as a development strategy in many national economies. Tourism literature captures a series of arguments that emphasize the contribution of tourism to local development by: creating new jobs, revitalizing cultural traditions, improving infrastructure, environmental protection, etc. For Romania, as well, it may be noted that tourism strategies included in the 2013-2016 Government Programme are oriented towards local tourism by: decentralizing the authorization and approval activity, developing an integrated tourism by capitalizing all the local resources (cultural, agricultural, handicraft, etc., connecting Romanian tourism to international trends, etc. In order to achieve the aforementioned objectives, the 2013-2016 Government Program provides the clarification on the issue of decentralization, since the current government believes that a balanced development of Romania can only be achieved through transfer of authority to the local, county and regional levels.

  16. Nuclear Manpower Development

    Energy Technology Data Exchange (ETDEWEB)

    Hwang, I. A.; Lee, K. B.; Shin, B. C. [KAERI, Daejeon (Korea, Republic of)

    2010-12-15

    The industry-university-research collaborative education is aiming at developing national nuclear human resources to satisfy with the increasing needs from the industry. For this efforts are being made to develop curricula customized to respective industry needs by improving existing ones. As the demand for training programs for the university students and domestic nuclear personnel was increasing owing to revitalization of nuclear industry, Nuclear Training Center (NTC) improved previous education programs to meet the needs. NTC has operated 2 education programs on research reactor experiments for the university students, and 18 programs on nuclear technology related experiment courses in 2010. Furthermore, the NTC developed new education programs related to 'standardized research reactor system design'. Also the request from universities for internship programs was increased by about three times in 2010 compared to those of the previous year, and this required to develop relevant curricula. In 2005, NTC developed KAERI-ACE, as a unique competency-based staff education system of Korea Atomic Energy Research Institute (KAERI). Based on the system, the NTC has performed 'systematic education'. In 2008, NTC was awarded Best HRD(Human Resource Development) in Public sector for the first time as a government-supported research institute. In 2009, the system was improved to become KAERI-ACE 2.0, based on which, in 2010, NTC improved and diversified education programs including various cyber training programs

  17. Developing a Professionalism Plan

    Directory of Open Access Journals (Sweden)

    Heather Pautler, PharmD

    2013-01-01

    Full Text Available Professionalism is a way of being which underlies all the responsibilities of a pharmacist and associated general and professional abilities. The Student Affairs Committee was charged with developing a college-wide professionalism plan to meet the Accreditation Council for Pharmacy Education (ACPE Standards 15.1 and 23. This plan was developed concurrently with a new curriculum. The plan was developed systematically with the following goals: 1 create a definition of professionalism, 2 determine outcomes of the plan, 3 identify existing components which should be continued and new components to be added, 4 ensure existing and new components are linked to outcomes and 5 develop a continuous assessment process for the plan. The proposed plan consists of curricular, co-curricular and extra-curricular activities designed to help students gain experience in three professionalism pillars: Competence, Connection and Character, as defined by Brown et al in “Taxonomy of Professionalism”. While knowledge and skills will be enhanced, the focus of development will be on student virtues, values and attitudes—that what they do defines who they are. The goal is to help students develop as people and professionals who value the high ideals expected of a pharmacist.

  18. Disability, poverty and development.

    Science.gov (United States)

    2002-01-01

    Disability is both a cause and consequence of poverty. Eliminating world poverty is unlikely to be achieved unless the rights and needs of people with disabilities are taken into account. According to the United Nations, one person in 20 has a disability. More than three out of four of these live in a developing country. More often than not they are among the poorest of the poor. Recent World Bank estimates suggest they may account for as many as one in five of the world's poorest. Disability limits access to education and employment, and leads to economic and social exclusion. Poor people with disabilities are caught in a vicious cycle of poverty and disability, each being both a cause and a consequence of the other. A large proportion of disability is preventable. Achieving the international development targets for economic, social and human development will undoubtedly reduce the levels of disability in many poor countries. However, general improvements in living conditions will not be enough. Specific steps are still required, not only for prevention, but also to ensure that people with disabilities are able to participate fully in the development process, obtain a fair share of the benefits, and claim their rights as full and equal members of society. An integrated approach is required, linking prevention and rehabilitation with empowerment strategies and changes in attitudes. This paper assesses the significance of disability as a key development issue, and its importance in relation to poverty, human rights, and the achievement of internationally agreed development targets. It also sets out ways in which development co-operation, including DFID's own work, can help incorporate the rights and needs of people with disabilities into the mainstream of poverty reduction work and the achievement of human rights.

  19. Technology development for safeguards

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ho Dong; Kang, H. Y.; Song, D. Y. [and others

    2005-04-01

    The objective of this project are to establish the safeguards technology of the nuclear proliferation resistance to the facilities which handle with high radioactivity nuclear materials like the spent fuel, to provide the foundation of the technical independency for the establishment of the effective management of domestic spent fuels, and to construct the base of the early introduction of the key technology relating to the back-end nuclear fuel cycle through the development of the safeguards technology of the DFDF of the nuclear non-proliferation. The essential safeguards technologies of the facility such as the measurement and account of nuclear materials and the C/S technology were carried out in this stage (2002-2004). The principal results of this research are the development of error reduction technology of the NDA equipment and a new NDA system for the holdup measurement of process materials, the development of the intelligent surveillance system based on the COM, the evaluation of the safeguardability of the Pyroprocessing facility which is the core process of the nuclear fuel cycle, the derivation of the research and development items which are necessary to satisfy the safeguards criteria of IAEA, and the presentation of the direction of the technology development relating to the future safeguards of Korea. This project is the representative research project in the field of the Korea's safeguards. The safeguards technology and equipment developed while accomplishing this project can be applied to other nuclear fuel cycle facilities as well as DFDF and will be contributed to increase the international confidence in the development of the nuclear fuel cycle facility of Korea and its nuclear transparency.

  20. Develop a Model Component

    Science.gov (United States)

    Ensey, Tyler S.

    2013-01-01

    During my internship at NASA, I was a model developer for Ground Support Equipment (GSE). The purpose of a model developer is to develop and unit test model component libraries (fluid, electrical, gas, etc.). The models are designed to simulate software for GSE (Ground Special Power, Crew Access Arm, Cryo, Fire and Leak Detection System, Environmental Control System (ECS), etc. .) before they are implemented into hardware. These models support verifying local control and remote software for End-Item Software Under Test (SUT). The model simulates the physical behavior (function, state, limits and 110) of each end-item and it's dependencies as defined in the Subsystem Interface Table, Software Requirements & Design Specification (SRDS), Ground Integrated Schematic (GIS), and System Mechanical Schematic.(SMS). The software of each specific model component is simulated through MATLAB's Simulink program. The intensiv model development life cycle is a.s follows: Identify source documents; identify model scope; update schedule; preliminary design review; develop model requirements; update model.. scope; update schedule; detailed design review; create/modify library component; implement library components reference; implement subsystem components; develop a test script; run the test script; develop users guide; send model out for peer review; the model is sent out for verifictionlvalidation; if there is empirical data, a validation data package is generated; if there is not empirical data, a verification package is generated; the test results are then reviewed; and finally, the user. requests accreditation, and a statement of accreditation is prepared. Once each component model is reviewed and approved, they are intertwined together into one integrated model. This integrated model is then tested itself, through a test script and autotest, so that it can be concluded that all models work conjointly, for a single purpose. The component I was assigned, specifically, was a

  1. [Adolescent psychosocial development].

    Science.gov (United States)

    Gaete, Verónica

    2015-01-01

    It is increasingly necessary that pediatricians have greater knowledge of adolescent health. To begin with they should be familiar with the psychosocial development of this period, an issue which is imperative for the health care of the age group. With that purpose, this article reviews the normal adolescent psychosocial development. Adolescence is a stage that has been progressively prolonged, during which fast and big changes occur, that lead human beings to become biologically, psychologically and socially mature, and potentially able to live independently. Developmental tasks of this period are the establishment of identity and the achievement of autonomy. Although it is a process of high individual variability in terms of its beginning and end, the progression through stages, the synchrony of development between the various areas, and in other aspects, the psychosocial development of this period usually have common characteristics and a progressive pattern of 3 phases: early, middle and late adolescence. Psychological, cognitive, social, sexual and moral development of young people in each of them are described in this article. Copyright © 2015 Sociedad Chilena de Pediatría. Publicado por Elsevier España, S.L.U. All rights reserved.

  2. Development of Neutron Spectrometer

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Chang Hee; Lee, J. S.; Seong, B. S. (and others)

    2007-06-15

    Neutron spectrometers which are used in the basic researches such as physics, chemistry and materials science and applied in the industry were developed at the horizontal beam port of HANARO reactor. In addition, the development of core components for neutron scattering and the upgrade of existing facilities are also performed. The vertical neutron reflectometer was fabricated and installed at ST3 beam port. The performance test of the reflectometer was completed and the reflectometer was opened to users. The several core parts and options were added in the polarized neutron spectrometer. The horizontal neutron reflectometer from Brookhaven National Laboratory was moved to HANARO and installed, and the performance of the reflectometer was examined. The HIPD was developed and the performance test was completed. The base shielding for TAS was fabricated. The soller collimator, Cu mosaic monochromator, Si BPC monochromator and position sensitive detector were developed and applied in the neutron spectrometer as part of core component development activities. In addition, the sputtering machine for mirror device are fabricated and the neutron mirror is made using the sputtering machine. The FCD was upgraded and the performance of the FCD are improved over the factor of 10. The integration and upgrade of the neutron detection system were also performed.

  3. States and Economic Development

    Directory of Open Access Journals (Sweden)

    Atul Kohli

    2009-06-01

    Full Text Available Today the Washington Consensus on development lies in tatters. The recent history of the developing world has been unkind to the core claim that a nation that opens its economy and keeps government's role to a minimum invariably experiences rapid economic growth. The evidence against this claim is strong: the developing world as a whole grew faster during the era of state intervention and import substitution (1950-1980 than in the more recent era of structural adjustment (1990-2005; and the recent economic performance of both Latin America and Sub-Saharan Africaregions that truly embraced neoliberalismhas lagged well behind that of many Asian economies, which have instead pursued judicial and unorthodox combinations of state intervention and economic openness. As scholars and policy makers reconstruct alternatives to the Washington Consensus on development, it is important to underline that prudent and effective state intervention and selective integration with the global economy have been responsible for development success in the past; they are also likely to remain the recipes for upward mobility in the global economy in the future."

  4. Background of CASBEE development

    Directory of Open Access Journals (Sweden)

    Shuzo Murakami

    2014-06-01

    Full Text Available Large amounts of resources and energy are consumed in the building sector. However, in response to the growing awareness of global environment problems, those in the building sector also recognized the necessity of making contributions toward the mitigation of environmental problems. The development of BREEAM was spurred by such circumstances. Its innovative scope and method attracted worldwide attention and eventually led to the global movement for developing assessment tools. Following BREEAM, other assessment tools for building environmental performance such as LEED were also developed and used around the world (BRE, 2013; USGBC, 2013, significantly contributing to the reduction of building-related environmental loads. Figure 2.1 shows the assessment tools developed worldwide. In Japan, under the leadership of the Ministry of Land, Infrastructure, Transport and Tourism (MLIT, a committee was established inside IBEC, and in 2001, initiated the development of tools to evaluate the environmental performance of buildings. The term Comprehensive Assessment System for Built Environment Efficiency CASBEE was coined through the activities of this committee.

  5. Hypertension in developing countries.

    Science.gov (United States)

    Tibazarwa, Kemi B; Damasceno, Albertino A

    2014-05-01

    The past 2 decades have seen a considerable global increase in cardiovascular disease, with hypertension remaining by far the most common. More than one-third of adults in Africa are hypertensive; as in the urban populations of most developing countries. Being a condition that occurs with relatively few symptoms, hypertension remains underdetected in many countries; especially in developing countries where routine screening at any point of health care is grossly underutilized. Because hypertension is directly related to cardiovascular disease, this has led to hypertension being the leading cause of adverse cardiovascular outcomes, as a result of patients living, often unknowingly, with uncontrolled hypertension for prolonged periods of time. In Africa, hypertension is the leading cause of heart failure; whereas at global levels, hypertension is responsible for more than half of deaths from stroke, just less than half of deaths from coronary artery disease, and for more than one-tenth of all global deaths. In this review, we discuss the escalating occurrence of hypertension in developing countries, before exploring the strengths and weaknesses of different measures to control hypertension, and the challenges of adopting these measures in developing countries. On a broad level, these include steps to curb the ripple effect of urbanization on the health and disease profile of developing societies, and suggestions to improve loopholes in various aspects of health care delivery that affect surveillance and management of hypertension. Furthermore, we consider how the industrial sectors' contributions toward the burden of hypertension can also be the source of the solution.

  6. Science and Team Development

    Directory of Open Access Journals (Sweden)

    Bryan R. Cole

    2006-07-01

    Full Text Available This paper explores a new idea about the future development of science and teams, and predicts its possible applications in science, education, workforce development and research. The inter-relatedness of science and teamwork developments suggests a growing importance of team facilitators’ quality, as well as the criticality of detailed studies of teamwork processes and team consortiums to address the increasing complexity of exponential knowledge growth and work interdependency. In the future, it will become much easier to produce a highly specialised workforce, such as brain surgeons or genome engineers, than to identify, educate and develop individuals capable of the delicate and complex work of multi-team facilitation. Such individuals will become the new scientists of the millennium, having extraordinary knowledge in variety of scientific fields, unusual mix of abilities, possessing highly developed interpersonal and teamwork skills, and visionary ideas in illuminating bold strategies for new scientific discoveries. The new scientists of the millennium, through team consortium facilitation, will be able to build bridges between the multitude of diverse and extremely specialised knowledge and interdependent functions to improve systems for the further benefit of mankind.

  7. Emergency Response Guideline Development

    Energy Technology Data Exchange (ETDEWEB)

    Gary D. Storrick

    2007-09-30

    Task 5 of the collaborative effort between ORNL, Brazil, and Westinghouse for the International Nuclear Energy Research Initiative entitled “Development of Advanced Instrumentation and Control for an Integrated Primary System Reactor” focuses on operator control and protection system interaction, with particular emphasis on developing emergency response guidelines (ERGs). As in the earlier tasks, we will use the IRIS plant as a specific example of an integrated primary system reactor (IPSR) design. The present state of the IRIS plant design – specifically, the lack of a detailed secondary system design – precludes establishing detailed emergency procedures at this time. However, we can create a structure for their eventual development. This report summarizes our progress to date. Section 1.2 describes the scope of this effort. Section 2 compares IPSR ERG development to the recent AP1000 effort, and identifies three key plant differences that affect the ERGs and control room designs. The next three sections investigate these differences in more detail. Section 3 reviews the IRIS Safety-by-Design™ philosophy and its impact on the ERGs. Section 4 looks at differences between the IRIS and traditional loop PWR I&C Systems, and considers their implications for both control room design and ERG development. Section 5 examines the implications of having one operating staff control multiple reactor units. Section 6 provides sample IRIS emergency operating procedures (EOPs). Section 7 summarizes our conclusions.

  8. Development of coal resources

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-09-01

    It is an important issue to expand stable coal supply areas for Japan, especially to assure stable supply of overseas coals. The investigations on geological structures in foreign countries perform surveys on geological structures in overseas coal producing countries and basic feasibility studies. The investigations select areas with greater business risks in coal producing countries and among private business entities. The geological structure investigations were carried out on China, Indonesia and Malaysia and the basic feasibility studies on Indonesia during fiscal 1994. The basic coal resource development investigations refer to the results of previous physical explorations and drilling tests to develop practical exploration technologies for coal resources in foreign countries. The development feasibility studies on overseas coals conduct technological consultation, surface surveys, physical explorations, and trial drilling operations, and provide fund assistance to activities related thereto. Fiscal 1994 has provided fund assistance to two projects in Indonesia and America. Fund loans are provided on investigations for development and import of overseas coals and other related activities. Liability guarantee for development fund is also described.

  9. Neuroinfections in developed versus developing countries.

    Science.gov (United States)

    Krcméry, Vladimír; Fedor-Freybergh, P G

    2007-06-01

    etiology, risk factors, therapy and outcome of neuroinfections (which is a burning public health and social problem in tropics) in other third world countries versus developed high-tech medical settings of US, EU and other high income countries, as presented by Benca et al. [12].

  10. PUBLISHER'S ANNOUNCEMENT: Editorial developments Editorial developments

    Science.gov (United States)

    Gillan, Rebecca

    2009-01-01

    We are delighted to announce that from January 2009, Professor Murray T Batchelor of the Australian National University, Canberra will be the new Editor-in-Chief of Journal of Physics A: Mathematical and Theoretical. Murray Batchelor has been Editor of the Mathematical Physics section of the journal since 2007. Prior to this, he served as a Board Member and an Advisory Panel member for the journal. His primary area of research is the statistical mechanics of exactly solved models. He holds a joint appointment in mathematics and physics and has held visiting positions at the Universities of Leiden, Amsterdam, Oxford and Tokyo. We very much look forward to working with Murray to continue to improve the journal's quality and interest to the readership. We would like to thank our outgoing Editor-in-Chief, Professor Carl M Bender. Carl has done a magnificent job as Editor-in-Chief and has worked tirelessly to improve the journal over the last five years. Carl has been instrumental in designing and implementing strategies that have enhanced the quality of papers published and service provided by Journal of Physics A: Mathematical and Theoretical. Notably, under his tenure, we have introduced the Fast Track Communications (FTC) section to the journal. This section provides a venue for outstanding short papers that report new and timely developments in mathematical and theoretical physics and offers accelerated publication and high visibility for our authors. During the last five years, we have raised the quality threshold for acceptance in the journal and now reject over 60% of submissions. As a result, papers published in Journal of Physics A: Mathematical and Theoretical are amongst the best in the field. We have also maintained and improved on our excellent receipt-to-first-decision times, which now average less than 50 days for papers. We have recently announced another innovation; the Journal of Physics A Best Paper Prize. These prizes will honour excellent papers

  11. Systematic Software Development

    DEFF Research Database (Denmark)

    Kuhrmann, Marco; Méndez Fernández, Daniel

    2015-01-01

    The speed of innovation and the global allocation of resources to accelerate development or to reduce cost put pressure on the software industry. In the global competition, especially so-called high-price countries have to present arguments why the higher development cost is justified and what...... makes these countries an attractive host for software companies. Often, high-quality engineering and excellent quality of products, e.g., machinery and equipment, are mentioned. Yet, the question is: Can such arguments be also found for the software industry? We aim at investigating the degree...... of professionalism and systematization of software development to draw a map of strengths and weaknesses. To this end, we conducted as a first step an exploratory survey in Germany, presented in this paper. In this survey, we focused on the perceived importance of the two general software engineering process areas...

  12. Advanced CCD camera developments

    Energy Technology Data Exchange (ETDEWEB)

    Condor, A. [Lawrence Livermore National Lab., CA (United States)

    1994-11-15

    Two charge coupled device (CCD) camera systems are introduced and discussed, describing briefly the hardware involved, and the data obtained in their various applications. The Advanced Development Group Defense Sciences Engineering Division has been actively designing, manufacturing, fielding state-of-the-art CCD camera systems for over a decade. These systems were originally developed for the nuclear test program to record data from underground nuclear tests. Today, new and interesting application for these systems have surfaced and development is continuing in the area of advanced CCD camera systems, with the new CCD camera that will allow experimenters to replace film for x-ray imaging at the JANUS, USP, and NOVA laser facilities.

  13. Solar Stirling system development

    Science.gov (United States)

    Stearns, J. W., Jr.; Won, Y. S.; Poon, P. T.; Das, R.; Chow, E. Y.

    1979-01-01

    A low-cost, high-efficiency dish-Stirling solar thermal-electric power system is being developed for test in 1981. System components are the solar concentrator, receiver, fossil fuel combustor, thermal energy storage (TES), engine-generator, and power processing. System conceptualization is completed and design is in progress. Two receiver alternatives are being evaluated, a direct-coupled receiver-engine configuration with no TES and a heat pipe receiver with TES. System cost projections are being made. Goals for the system development task are (1) to develop an advanced dish-Stirling technology, utilizing a team of industrial contractors, (2) to demonstrate that technology at the system level, and (3) to determine how to achieve low production cost.

  14. Patterns in Software Development

    DEFF Research Database (Denmark)

    Corry, Aino Vonge

    of abstract solutions often occurring problems, and the benefits they are claimed to provide, are: common vocabulary, enhanced documentation and shared experience. In the writing of our masters thesis, it occurred to us that things could be better, and that something had to be done to actually achieve......This thesis springs from a wish to make a better place to live in. It could be argued that other studies, like marine ecology, biotechnology or medicine might be more suited for that wish. But the subjects I studied were computer science and mathematics and I had to take the consequence and make...... described in this thesis has the potential to help developers in their system development and thereby, in turn, make the world a better place to live in for developers. ...

  15. Honda humanoid robots development.

    Science.gov (United States)

    Hirose, Masato; Ogawa, Kenichi

    2007-01-15

    Honda has been doing research on robotics since 1986 with a focus upon bipedal walking technology. The research started with straight and static walking of the first prototype two-legged robot. Now, the continuous transition from walking in a straight line to making a turn has been achieved with the latest humanoid robot ASIMO. ASIMO is the most advanced robot of Honda so far in the mechanism and the control system. ASIMO's configuration allows it to operate freely in the human living space. It could be of practical help to humans with its ability of five-finger arms as well as its walking function. The target of further development of ASIMO is to develop a robot to improve life in human society. Much development work will be continued both mechanically and electronically, staying true to Honda's 'challenging spirit'.

  16. LHC Report: machine development

    CERN Multimedia

    Rogelio Tomás García for the LHC team

    2015-01-01

    Machine development weeks are carefully planned in the LHC operation schedule to optimise and further study the performance of the machine. The first machine development session of Run 2 ended on Saturday, 25 July. Despite various hiccoughs, it allowed the operators to make great strides towards improving the long-term performance of the LHC.   The main goals of this first machine development (MD) week were to determine the minimum beam-spot size at the interaction points given existing optics and collimation constraints; to test new beam instrumentation; to evaluate the effectiveness of performing part of the beam-squeezing process during the energy ramp; and to explore the limits on the number of protons per bunch arising from the electromagnetic interactions with the accelerator environment and the other beam. Unfortunately, a series of events reduced the machine availability for studies to about 50%. The most critical issue was the recurrent trip of a sextupolar corrector circuit –...

  17. Automatic Program Development

    DEFF Research Database (Denmark)

    by members of the IFIP Working Group 2.1 of which Bob was an active member. All papers are related to some of the research interests of Bob and, in particular, to the transformational development of programs and their algorithmic derivation from formal specifications. Automatic Program Development offers......Automatic Program Development is a tribute to Robert Paige (1947-1999), our accomplished and respected colleague, and moreover our good friend, whose untimely passing was a loss to our academic and research community. We have collected the revised, updated versions of the papers published in his...... honor in the Higher-Order and Symbolic Computation Journal in the years 2003 and 2005. Among them there are two papers by Bob: (i) a retrospective view of his research lines, and (ii) a proposal for future studies in the area of the automatic program derivation. The book also includes some papers...

  18. [Development of new vaccines].

    Science.gov (United States)

    González-Romo, Fernando; Picazo, Juan J

    2015-10-01

    Recent and important advances in the fields of immunology, genomics, functional genomics, immunogenetics, immunogenomics, bioinformatics, microbiology, genetic engineering, systems biology, synthetic biochemistry, proteomics, metabolomics and nanotechnology, among others, have led to new approaches in the development of vaccines. The better identification of ideal epitopes, the strengthening of the immune response due to new adjuvants, and the search of new routes of vaccine administration, are good examples of advances that are already a reality and that will favour the development of more vaccines, their use in indicated population groups, or its production at a lower cost. There are currently more than 130 vaccines are under development against the more wished (malaria or HIV), difficult to get (CMV or RSV), severe re-emerging (Dengue or Ebola), increasing importance (Chagas disease or Leishmania), and nosocomial emerging (Clostridium difficile or Staphylococcus aureus) infectious diseases. Copyright © 2015. Published by Elsevier España, S.L.U.

  19. Epetra developers coding guidelines.

    Energy Technology Data Exchange (ETDEWEB)

    Heroux, Michael Allen; Sexton, Paul Michael

    2003-12-01

    Epetra is a package of classes for the construction and use of serial and distributed parallel linear algebra objects. It is one of the base packages in Trilinos. This document describes guidelines for Epetra coding style. The issues discussed here go beyond correct C++ syntax to address issues that make code more readable and self-consistent. The guidelines presented here are intended to aid current and future development of Epetra specifically. They reflect design decisions that were made in the early development stages of Epetra. Some of the guidelines are contrary to more commonly used conventions, but we choose to continue these practices for the purposes of self-consistency. These guidelines are intended to be complimentary to policies established in the Trilinos Developers Guide.

  20. City health development planning.

    Science.gov (United States)

    Green, Geoff; Acres, John; Price, Charles; Tsouros, Agis

    2009-11-01

    The objective of this evaluation was to review the evolution and process of city health development planning (CHDP) in municipalities participating in the Healthy Cities Network organized by the European Region of the World Health Organization. The concept of CHDP combines elements from three theoretical domains: (a) health development, (b) city governance and (c) urban planning. The setting was the 56 cities which participated in Phase III (1998-2002) of the Network. Evidence was gathered from documents either held in WHO archives or made available from Network cities and from interviews with city representatives. CHDPs were the centrepiece of Phase III, evolving from city health plans developed in Phase II. They are strategic documents giving direction to municipalities and partner agencies. Analysis revealed three types of CHDP, reflecting the realpolitik of each city. For many cities, the process of CHDP was as important as the plan itself.