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Sample records for justin yifu lin

  1. QING LIN

    Indian Academy of Sciences (India)

    QING LIN. Articles written in Journal of Genetics. Volume 96 Issue 4 September 2017 pp 535-544 RESEARCH ARTICLE. Effects of genetic variants of the bovine WNT8A gene on nine important growth traits in beef cattle · YONG-ZHEN HUANG YONG ZOU QING LIN HUA HE LI ZHENG ZI-JING ZHANG YONG-LONG DANG ...

  2. Justine user`s manual

    Energy Technology Data Exchange (ETDEWEB)

    Lee, S.R.

    1995-10-01

    Justine is the graphical user interface to the Los Alamos Radiation Modeling Interactive Environment (LARAMIE). It provides LARAMIE customers with a powerful, robust, easy-to-use, WYSIWYG interface that facilitates geometry construction and problem specification. It is assumed that the reader is familiar with LARAMIE, and the transport codes available, i.e., MCNPTM and DANTSYSTM. No attempt is made in this manual to describe these codes in detail. Information about LARAMIE, DANTSYS, and MCNP are available elsewhere. It i also assumed that the reader is familiar with the Unix operating system and with Motif widgets and their look and feel. However, a brief description of Motif and how one interacts with it can be found in Appendix A.

  3. Kroonika esitleb : Justin Timberlake ja Rod Stewart / Justin Timberlake ; interv. Katrin Lust-Buchanan

    Index Scriptorium Estoniae

    Timberlake, Justin

    2006-01-01

    Meesteajakirja GQ auhindade jagamise tseremoonial Londonis sai ajakirja Kroonika reporter jutule aasta rahvusvahelisima mehe tiitli pälvinud Justin Timberlake'i ja elutööpreemia saanud Rod Stewartiga

  4. Justin Bieber - en toneangivende formidler til tweens

    OpenAIRE

    Lundeby, Maria Celine Kolberg

    2014-01-01

    Ønsket mitt med oppgaven har vært å skape en bevissthet om at populærkulturen er en formidler av noe, og at dette noe bærer i seg potensialet til å ha direkte betydning for vanlige menneskers liv. Gjennom dette utblikket har målet vært å synliggjøre noen eksempler på hvordan det som formidles kan bli gode innfallsvinkler til samtaler om og forkynnelse av kristen tro til tweens. Selv om denne oppgaven har tatt utgangspunkt i et veldig konkret eksempel, Justin Bieber, er de grunnleg...

  5. Justin Ukpongs Jesus. Emmanuel for our times

    Directory of Open Access Journals (Sweden)

    Tshehla, Maarman S

    2015-12-01

    Full Text Available Africa has a long association with the BibleAt the time of Jesus, the Bible was being read in AfricaSince then, the Bible has continued to be read in Africa (Mbiti 1994:27. Jesus Christ is the key character with which many who come to the Bible are concerned, academics as well as countless ordinary readers. Beyond the methodological considerations wherein this leading African chronicler of African Biblical Hermeneutics has made an immense contribution, what specific insights might we glean from Justin Ukpongs work about the Jesus of the canonical evangelists vis-vis our work as organic intellectuals? What does Ukpongs Jesus offer present-day South Africa, if one with a missiological interest may extrapolate?

  6. Anaphoric Reference in Justin Bieber's Album “Believe Acoustic”

    OpenAIRE

    Situmorang, Hisarmauli Desi Natalina; Natsir, Muhammad

    2014-01-01

    This research focused on anaphoric reference used in Justin Bieber's Album “Believe Acoustic”. The research conducted by using descriptive qualitative method. The data was collected from the Justin Bieber's album “Believe Acoustic”. The finding of the thesis show that there are 64 lines (sentence, phrase) that consist of 3 anaphoric reference which are anaphora (10), cataphora (6), and zero anaphora (48). The most dominant types is zero anaphora, which means the writer want to create an impli...

  7. Sugar Free with Justin T.: Diabetes Education through Community Partnerships

    Science.gov (United States)

    Thomas, Justin B.; Donaldson, Joseph L.

    2014-01-01

    This article describes the design, development, and delivery of an Extension community cable television program, "Sugar Free with Justin T.," in Roane County, Tennessee. The program targets diabetics, pre-diabetics, and those who care for them, with practical information and demonstrations to improve dietary quality. In addition to…

  8. Visualization of geometry and tally data using MCNP and Justine

    International Nuclear Information System (INIS)

    Cox, L.J.; Favorite, J.A.

    1999-01-01

    The Monte Carlo N-Particle (MCNP) transport code is a general-purpose code that can be used for neutron, photon, electron, or coupled neutron/photon/electron transport, including the capability to calculate eigenvalues for neutron-multiplying systems. The code treats an arbitrary three-dimensional configuration of materials in geometric cells bounded by first- and second-degree surfaces and fourth-degree elliptical tori. Justine is the graphical user interface and problem setup tool for the Los Alamos Radiation Modeling Interactive Environment (LARAMIE). Its purpose is to serve as a convenient and very general interface for setting up physics calculations and linking together the disparate radiation transport codes under a single front-end. Currently, the LARAMIE system includes MCNP and the deterministic transport code suit DANTSYS (ONEDANT, TWODANT, and THREEDANT, for one-, two-, and three-dimensional geometries, respectively). Justine is currently available through the Radiation Safety Information Computational Center to members of the criticality safety community for evaluation and use. The authors will demonstrate the capabilities of both codes for visualization of geometries and results from a variety of criticality problems

  9. LINS Curve in Romanian Economy

    Directory of Open Access Journals (Sweden)

    Emilian Dobrescu

    2016-02-01

    Full Text Available The paper presents theoretical considerations and empirical evidence to test the validity of the Laffer in Narrower Sense (LINS curve as a parabola with a maximum. Attention is focused on the so-called legal-effective tax gap (letg. The econometric application is based on statistical data (1990-2013 for Romania as an emerging European economy. Three cointegrating regressions (fully modified least squares, canonical cointegrating regression and dynamic least squares and three algorithms, which are based on instrumental variables (two-stage least squares, generalized method of moments, and limited information maximum likelihood, are involved.

  10. Abject Magic: Reasoning Madness in Justine Larbalestier's "Magic or Madness" Trilogy

    Science.gov (United States)

    Potter, Troy

    2013-01-01

    This paper explores the representation of magic and madness in Justine Larbalestier's "Magic or Madness" trilogy (2005-2007). Throughout the series, magic is constructed as an abject and disabling force that threatens to disable magic-wielders, either through madness or death. Despite being represented as a ubiquitous force, the…

  11. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

    Directory of Open Access Journals (Sweden)

    Alan L Jiao

    Full Text Available As the founding member of the microRNA (miRNA gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE, and by lin-4 itself. In this study, we sought to (1 identify additional factors required for lin-4 reporter expression, and (2 validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4, positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

  12. lin-4 and the NRDE pathway are required to activate a transgenic lin-4 reporter but not the endogenous lin-4 locus in C. elegans.

    Science.gov (United States)

    Jiao, Alan L; Foster, Daniel J; Dixon, Julia; Slack, Frank J

    2018-01-01

    As the founding member of the microRNA (miRNA) gene family, insights into lin-4 regulation and function have laid a conceptual foundation for countless miRNA-related studies that followed. We previously showed that a transcriptional lin-4 reporter in C. elegans was positively regulated by a lin-4-complementary element (LCE), and by lin-4 itself. In this study, we sought to (1) identify additional factors required for lin-4 reporter expression, and (2) validate the endogenous relevance of a potential positive autoregulatory mechanism of lin-4 expression. We report that all four core nuclear RNAi factors (nrde-1, nrde-2, nrde-3 and nrde-4), positively regulate lin-4 reporter expression. In contrast, endogenous lin-4 levels were largely unaffected in nrde-2;nrde-3 mutants. Further, an endogenous LCE deletion generated by CRISPR-Cas9 revealed that the LCE was also not necessary for the activity of the endogenous lin-4 promoter. Finally, mutations in mature lin-4 did not reduce primary lin-4 transcript levels. Taken together, these data indicate that under growth conditions that reveal effects at the transgenic locus, a direct, positive autoregulatory mechanism of lin-4 expression does not occur in the context of the endogenous lin-4 locus.

  13. Justin Bieber, do doc ao Instagram: a estetização da vida

    Directory of Open Access Journals (Sweden)

    Denise Tavares

    2013-12-01

    Full Text Available Alguns documentários biográficos de celebridades reafirmam um modelo de produção audiovisual que encerra a história de vida no show e na fama, articulando o tensionamento entre biografia, tecnologia, experiência estética e afeto. Tais imbricamentos são ainda mais visíveis quando considerada a fruição desta celebridade, “consumida” em outras possibilidades biográficas que remixa webvideos postados no Youtube e/ou fotos no Instagram. Para discutir estas questões, o artigo destaca Justin Bieber, tendo como ponto de partida o documentário Justin Bieber – Never Say Never (2011, de Jon M. Chu e o Instagram, em um recorte que privilegia a experiência dos desejos dos fãs.

  14. In vitro expansion of Lin+ and Lin- mononuclear cells from human peripheral blood

    Science.gov (United States)

    Norhaiza, H. Siti; Rohaya, M. A. W.; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul

    2013-11-01

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin-) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin+) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin- cell population. The ability of Lin+ and Lin- to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin+ and Lin- were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin+ mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin- stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation medium support Lin

  15. Lin28a regulates germ cell pool size and fertility

    Science.gov (United States)

    Shinoda, Gen; de Soysa, T. Yvanka; Seligson, Marc T.; Yabuuchi, Akiko; Fujiwara, Yuko; Huang, Pei Yi; Hagan, John P.; Gregory, Richard I.; Moss, Eric G.; Daley, George Q.

    2013-01-01

    Overexpression of LIN28A is associated with human germ cell tumors and promotes primordial germ cell (PGC) development from embryonic stem cells in vitro and in chimeric mice. Knockdown of Lin28a inhibits PGC development in vitro, but how constitutional Lin28a deficiency affects the mammalian reproductive system in vivo remains unknown. Here, we generated Lin28a knockout (KO) mice and found that Lin28a deficiency compromises the size of the germ cell pool in both males and females by affecting PGC proliferation during embryogenesis. Interestingly however, in Lin28a KO males the germ cell pool partially recovers during postnatal expansion, while fertility remains impaired in both males and females mated to wild type mice. Embryonic overexpression of let-7, a microRNA negatively regulated by Lin28a, reduces the germ cell pool, corroborating the role of the Lin28a/let-7 axis in regulating the germ lineage. PMID:23378032

  16. Justin Bieber, do doc ao Instagram: a estetização da vida

    OpenAIRE

    Tavares, Denise; Pinto, Raphael

    2013-01-01

    Alguns documentários biográficos de celebridades reafirmam um modelo de produção audiovisual que encerra a história de vida no show e na fama, articulando o tensionamento entre biografia, tecnologia, experiência estética e afeto. Tais imbricamentos são ainda mais visíveis quando considerada a fruição desta celebridade, “consumida” em outras possibilidades biográficas que remixa webvideos postados no Youtube e/ou fotos no Instagram. Para discutir estas questões, o artigo destaca Justin Bieber,...

  17. On the Social Nature of Objectivity: Helen Longino and Justin Biddle

    Directory of Open Access Journals (Sweden)

    Jaana Eigi

    2015-11-01

    Full Text Available According to Helen Longino, objectivity is necessarily social as it depends on critical interactions in community. Justin Biddle argues that Longino’s account presupposes individuals that are completely open to any criticism; as such individuals are in principle able to criticise their beliefs on their own, Longino's account is not really social. In the first part of my paper I argue that even for completely open individuals, criticism for maintaining objectivity is only possible in community. In the second part I challenge Biddle’s interpretation of Longino’s conception of the individual. I conclude that Longino’s account is necessarily social.

  18. The battle for Yellowstone: Morality and the  sacred roots of environmental conflict, by Justin Farrell

    Science.gov (United States)

    John Schelhas

    2017-01-01

    A growing number of intractable environmental conflicts involving interest groups with deeply held beliefs are resisting resolution in spite of extensive scientific analysis and legal and bureaucratic attention. Justin Farrell addresses three such conflicts in the Greater Yellowstone Ecosystem (GYE) as moral and spiritual conflicts, each uniquely animated by history,...

  19. The Victorian Philanthropic Quixote: Donna Quixote, by Justin McCarthy

    Directory of Open Access Journals (Sweden)

    Pedro Javier Pardo

    2012-12-01

    Full Text Available The paper undertakes the analysis of a little known Victorian quixotic novel, Donna Quixote, by Justin McCarthy. In so doing, it places the latter, in the first place, within the conception of quixotism characteristic of the Victorian age and, in the second place, within the previous tradition of female quixotes, particularly as a response to George Eliot’s Middlemarch. Then, the text studies the novel’s originality within the English quixotic tradition, which lies in the way it relates quixotism to both philanthropy and feminism, not just by means of the heroine but also of some quixotic secondary figures, and argues the author’s conservative position in the debate on women’s rights known as the woman question. Finally, the paper illustrates such a position and its ideological context by presenting another “Donna Quixote,” in this case a satiric cartoon on the so-called new woman.

  20. Analysis list: lin-13 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available lin-13 Embryo,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/...lin-13.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-13.5.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/target/lin-13.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Embryo....tsv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-13.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Embryo.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  1. Justine Effect: Punishment of the Unduly Self-Sacrificing Cooperative Individuals

    Science.gov (United States)

    Kuběna, Aleš Antonín; Houdek, Petr; Lindová, Jitka; Příplatová, Lenka; Flegr, Jaroslav

    2014-01-01

    Background Allowing players to punish their opponents in Public Goods Game sustains cooperation within a group and thus brings advantage to the cooperative individuals. However, the possibility of punishment of the co-players can result in antisocial punishment, the punishment of those players who contribute the most in the group. To better understand why antisocial punishment exists, it must be determined who are the anti-social punishers and who are their primary targets. Methods For resolving these questions we increased the number of players in a group from usual four to twelve. Each group played six rounds of the standard Public Goods Game and six rounds of the Public Goods Game with punishment. Each player in each round received 20 CZK ($ 1.25). Players (N = 118) were rematched after each round so that they would not take into consideration opponents' past behavior. Results The amount of the punishment received correlated negatively with the contribution (ρ = −0.665, ppunishment obtained was U-shaped (R2 = 0.678, ppunishment was present in all groups, and in eight out of ten groups the Justine Effect (the positive correlation between the contribution to the public pool and the risk of suffering punishment in the subpopulation of altruistic players) emerged. In our sample, 22.5% subjects, all of them Free riders and low contributors, punished the altruistic players. Conclusions The results of our experimental game-study revealed the existence of the Justine effect – the positive correlation between the contribution to the public pool by a subpopulation of the most altruistic players, and the amount of punishment these players obtained from free-riders. PMID:24670974

  2. Justine effect: punishment of the unduly self-sacrificing cooperative individuals.

    Science.gov (United States)

    Kuběna, Aleš Antonín; Houdek, Petr; Lindová, Jitka; Příplatová, Lenka; Flegr, Jaroslav

    2014-01-01

    Allowing players to punish their opponents in Public Goods Game sustains cooperation within a group and thus brings advantage to the cooperative individuals. However, the possibility of punishment of the co-players can result in antisocial punishment, the punishment of those players who contribute the most in the group. To better understand why antisocial punishment exists, it must be determined who are the anti-social punishers and who are their primary targets. For resolving these questions we increased the number of players in a group from usual four to twelve. Each group played six rounds of the standard Public Goods Game and six rounds of the Public Goods Game with punishment. Each player in each round received 20 CZK ($ 1.25). Players (N = 118) were rematched after each round so that they would not take into consideration opponents' past behavior. The amount of the punishment received correlated negatively with the contribution (ρ = -0.665, pboarder of the upper quartile. The antisocial punishment was present in all groups, and in eight out of ten groups the Justine Effect (the positive correlation between the contribution to the public pool and the risk of suffering punishment in the subpopulation of altruistic players) emerged. In our sample, 22.5% subjects, all of them Free riders and low contributors, punished the altruistic players. The results of our experimental game-study revealed the existence of the Justine effect--the positive correlation between the contribution to the public pool by a subpopulation of the most altruistic players, and the amount of punishment these players obtained from free-riders.

  3. Candice Lin: paisaje, territorio y fronteras (Candice Lin: Landscape, Territory and Boundaries

    Directory of Open Access Journals (Sweden)

    Gabriel Baltodano Román

    2017-11-01

    Full Text Available Se analizan los contenidos ideológicos de la acuarela «Nacimiento de una nación» (2008, de Candice Lin. A partir de nociones como territorio, tropo caníbal, tipo botánico tropical y pensamiento fronterizo, se plantea una interpretación de esa paisajística pictórica, en que la artista-activista reflexiona sobre el régimen de representación visual. Mediante diversos procedimientos formales, Lin pone en entredicho preceptos centrales de la mentalidad colonialista, que contrapone a las concepciones indigenistas. Abstract An analysis is provided of the ideological contents of the watercolor “Birth of a Nation” (2008, by Candice Lin. This interpretation of this pictorial landscape is based on notions such as territory, cannibal tropes, tropical botanical types and border thinking. The artist activist reflects here on the regime of visual representation. Using different formal procedures, Lin questions central precepts of the colonialist mentality, in contrast with indigenous conceptions.

  4. The Lin28/let-7 Axis Regulates Glucose Metabolism

    NARCIS (Netherlands)

    Zhu, Hao; Shyh-Chang, Ng; Segre, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G.; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2011-01-01

    The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by inhibiting let-7 biogenesis. We have uncovered unexpected roles for the Lin28/let-7 pathway in regulating-metabolism. When overexpressed in mice, both

  5. Analysis list: lin-35 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available lin-35 Adult,Larvae + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/l...in-35.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/lin-35.5.tsv http://dbarchive.bioscienced...bc.jp/kyushu-u/ce10/target/lin-35.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Adult.t...sv,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/lin-35.Larvae.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Adult.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Larvae.gml ...

  6. Justine effect: punishment of the unduly self-sacrificing cooperative individuals.

    Directory of Open Access Journals (Sweden)

    Aleš Antonín Kuběna

    Full Text Available Allowing players to punish their opponents in Public Goods Game sustains cooperation within a group and thus brings advantage to the cooperative individuals. However, the possibility of punishment of the co-players can result in antisocial punishment, the punishment of those players who contribute the most in the group. To better understand why antisocial punishment exists, it must be determined who are the anti-social punishers and who are their primary targets.For resolving these questions we increased the number of players in a group from usual four to twelve. Each group played six rounds of the standard Public Goods Game and six rounds of the Public Goods Game with punishment. Each player in each round received 20 CZK ($ 1.25. Players (N = 118 were rematched after each round so that they would not take into consideration opponents' past behavior.The amount of the punishment received correlated negatively with the contribution (ρ = -0.665, p<0.001. However, this correlation was positive for players in the highest contributors-quartile (ρ = 0.254, p<0.001. Therefore, the graph of relation between the contribution given and punishment obtained was U-shaped (R2 = 0.678, p<0.001 with the inflection point near the left boarder of the upper quartile. The antisocial punishment was present in all groups, and in eight out of ten groups the Justine Effect (the positive correlation between the contribution to the public pool and the risk of suffering punishment in the subpopulation of altruistic players emerged. In our sample, 22.5% subjects, all of them Free riders and low contributors, punished the altruistic players.The results of our experimental game-study revealed the existence of the Justine effect--the positive correlation between the contribution to the public pool by a subpopulation of the most altruistic players, and the amount of punishment these players obtained from free-riders.

  7. The Lin28/let-7 axis regulates glucose metabolism

    Science.gov (United States)

    Zhu, Hao; Shyh-Chang, Ng; Segrè, Ayellet V.; Shinoda, Gen; Shah, Samar P.; Einhorn, William S.; Takeuchi, Ayumu; Engreitz, Jesse M.; Hagan, John P.; Kharas, Michael G; Urbach, Achia; Thornton, James E.; Triboulet, Robinson; Gregory, Richard I.; Altshuler, David; Daley, George Q.

    2012-01-01

    SUMMARY The let-7 tumor suppressor microRNAs are known for their regulation of oncogenes, while the RNA-binding proteins Lin28a/b promote malignancy by blocking let-7 biogenesis. In studies of the Lin28/let-7 pathway, we discovered unexpected roles in regulating metabolism. When overexpressed in mice, both Lin28a and LIN28B promoted an insulin-sensitized state that resisted high fat diet-induced diabetes, whereas muscle-specific loss of Lin28a and overexpression of let-7 resulted in insulin resistance and impaired glucose tolerance. These phenomena occurred in part through let-7-mediated repression of multiple components of the insulin-PI3K-mTOR pathway, including IGF1R, INSR, and IRS2. The mTOR inhibitor rapamycin abrogated the enhanced glucose uptake and insulin-sensitivity conferred by Lin28a in vitro and in vivo. In addition, we found that let-7 targets were enriched for genes that contain SNPs associated with type 2 diabetes and fasting glucose in human genome-wide association studies. These data establish the Lin28/let-7 pathway as a central regulator of mammalian glucose metabolism. PMID:21962509

  8. Using Lin's method to solve Bykov's problems

    Science.gov (United States)

    Knobloch, Jürgen; Lamb, Jeroen S. W.; Webster, Kevin N.

    2014-10-01

    We consider nonwandering dynamics near heteroclinic cycles between two hyperbolic equilibria. The constituting heteroclinic connections are assumed to be such that one of them is transverse and isolated. Such heteroclinic cycles are associated with the termination of a branch of homoclinic solutions, and called T-points in this context. We study codimension-two T-points and their unfoldings in Rn. In our consideration we distinguish between cases with real and complex leading eigenvalues of the equilibria. In doing so we establish Lin's method as a unified approach to (re)gain and extend results of Bykov's seminal studies and related works. To a large extent our approach reduces the study to the discussion of intersections of lines and spirals in the plane. Case (RR): Under open conditions on the eigenvalues, there exist open sets in parameter space for which there exist periodic orbits close to the heteroclinic cycle. In addition, there exist two one-parameter families of homoclinic orbits to each of the saddle points p1 and p2.See Theorem 2.1 and Proposition 2.2 for precise statements and Fig. 2 for bifurcation diagrams. Cases (RC) and (CC): At the bifurcation point μ=0 and for each N≥2, there exists an invariant set S0N close to the heteroclinic cycle on which the first return map is topologically conjugated to a full shift on N symbols. For any fixed N≥2, the invariant set SμN persists for |μ| sufficiently small.In addition, there exist infinitely many transversal and non-transversal heteroclinic orbits connecting the saddle points p1 and p2 in a neighbourhood of μ=0, as well as infinitely many one-parameter families of homoclinic orbits to each of the saddle points.For full statements of the results see Theorem 2.3 and Propositions 2.4, 2.5 and Fig. 3 for bifurcation diagrams. The dynamics near T-points has been studied previously by Bykov [6-10], Glendinning and Sparrow [20], Kokubu [27,28] and Labouriau and Rodrigues [30,31,38]. See also the surveys

  9. In vitro expansion of Lin{sup +} and Lin{sup −} mononuclear cells from human peripheral blood

    Energy Technology Data Exchange (ETDEWEB)

    Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul [School of Bioscience and Biotechnology, Faculty of Science and Technology, Universiti Kebangsaan Malaysia, 43600, Selangor (Malaysia); Rohaya, M. A. W. [Department of Orthodontics, Faculty of Dentistry, Universiti Kebangsaan Malaysia, 50300, Kuala Lumpur (Malaysia)

    2013-11-27

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin{sup −}) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin{sup +}) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin{sup −} cell population. The ability of Lin{sup +} and Lin{sup −} to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin{sup +} and Lin{sup −} were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin{sup +} mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin{sup −} stem cells were not able to survive in proliferation medium however

  10. Selective blockade of microRNA processing by Lin-28

    Science.gov (United States)

    Viswanathan, Srinivas R.; Daley, George Q.; Gregory, Richard I.

    2012-01-01

    MicroRNAs (miRNAs) play critical roles in development, and dysregulation of miRNA expression has been observed in human malignancies. Recent evidence suggests that the processing of several primary miRNA transcripts (pri-miRNAs) is blocked post-transcriptionally in embryonic stem (ES) cells, embryonal carcinoma (EC) cells, and primary tumors. Here we show that Lin-28, a developmentally regulated RNA-binding protein, selectively blocks the processing of pri-let-7 miRNAs in embryonic cells. Using in vitro and in vivo studies, we demonstrate that Lin-28 is necessary and sufficient for blocking Microprocessor-mediated cleavage of pri-let-7 miRNAs. Our results identify Lin-28 as a negative regulator of miRNA biogenesis and suggest that Lin-28 may play a central role in blocking miRNA-mediated differentiation in stem cells and certain cancers. PMID:18292307

  11. Lin28 sustains early renal progenitors and induces Wilms tumor

    Science.gov (United States)

    Urbach, Achia; Yermalovich, Alena; Zhang, Jin; Spina, Catherine S.; Zhu, Hao; Perez-Atayde, Antonio R.; Shukrun, Rachel; Charlton, Jocelyn; Sebire, Neil; Mifsud, William; Dekel, Benjamin; Pritchard-Jones, Kathy; Daley, George Q.

    2014-01-01

    Wilms Tumor, the most common pediatric kidney cancer, evolves from the failure of terminal differentiation of the embryonic kidney. Here we show that overexpression of the heterochronic regulator Lin28 during kidney development in mice markedly expands nephrogenic progenitors by blocking their final wave of differentiation, ultimately resulting in a pathology highly reminiscent of Wilms tumor. Using lineage-specific promoters to target Lin28 to specific cell types, we observed Wilms tumor only when Lin28 is aberrantly expressed in multiple derivatives of the intermediate mesoderm, implicating the cell of origin as a multipotential renal progenitor. We show that withdrawal of Lin28 expression reverts tumorigenesis and markedly expands the numbers of glomerulus-like structures and that tumor formation is suppressed by enforced expression of Let-7 microRNA. Finally, we demonstrate overexpression of the LIN28B paralog in a significant percentage of human Wilms tumor. Our data thus implicate the Lin28/Let-7 pathway in kidney development and tumorigenesis. PMID:24732380

  12. Lin's theory of flux and nuclear reactions

    International Nuclear Information System (INIS)

    Ping-Wha Lin

    2002-01-01

    Mathematical development of Lin's theory of flux is presented. Based on the Theory, when a chemical reaction system is subjected to a high time rate of temperature change, it changes from equilibrium to non-equilibrium conditions. It is proved mathematically that, when a gas system is subjected to a high time rate of temperature increase, the activities of particles (molecules, atoms or nuclei, and electrons) are increased: the particles are accelerated; frequencies and amplitudes of electron and atomic vibrations in a molecule increased; average kinetic energy of the particles increased; atomic bonds are ruptured; electrons are caused to leave their orbits. If most or all of the electrons leave their orbits, the gas fluid becomes plasma, which is very active chemically. The acceleration of nuclei in the dynamic condition can lead to nuclear reactions. In the pilot plant studies conducted at Research Triangle, NC, USA, for SO 2 conversion to SO 3 by rapid heating, a 10-ft high vertically fired combustor (VFC) was used. Air containing 0.5% SO 2 is forced continuously through the VFC, where it is heated by burners for conversion of SO 2 to SO 3 . During the idle period of operation, no external heat is added to the system by turning off the burners. It is observed that, as the air passing through the VFC during the idle period of sixteen hours, the temperature of the flowing air consistently rises up rapidly from ambient temperature (90 deg F) at inlet of the VFC to an average temperature as high as 582 deg F (in the range of 840 deg F to 455 deg F) at one section of the VFC, an increase of about 500 deg F. The air flow temperature increase of such large magnitude and long duration clearly indicates that nuclear reactions are present in VFC. It is also found that the water vapour in the air stream has completely disappeared in the VFC, for no sulphuric acid formation resulting from the reaction of water and SO 3 is detected there. Presumably, the water vapour in the

  13. Ruminating on Justin S. Ukpong’s inculturation hermeneutics and its implications for the study of African Biblical Hermeneutics today

    Directory of Open Access Journals (Sweden)

    Madipoane Masenya (ngwan’a Mphahlele

    2016-11-01

    Full Text Available In African biblical scholarship, the concept of inculturation hermeneutics has come to be almost, if not always, linked to the late Professor Justin S. Ukpong, the Nigerian New Testament scholar. In inculturation hermeneutics, argued Ukpong, the past of the biblical text is not supposed to be studied as an end in itself, but as a means to an end. Ukpong (2002 could thus argue: ‘Thus in inculturation hermeneutics, the past collapses into the present, and exegesis fuses with hermeneutics’ (p. 18. What does Ukpong’s concept of inculturation hermeneutics actually entail? Which implications does his notion of the fusion of exegesis and hermeneutics have for the theory and praxis of African Biblical Hermeneutics particularly on the African continent today? The preceding questions will be engaged with in this article.

  14. 93 une urbanisation linéaire, dynamique demographique et ...

    African Journals Online (AJOL)

    Mohand

    d'Alger, dans l'ensemble Sahel-Mitidja sur un linéaire côtier de 2 km. Rattaché administrativement à la daira de ... connait une dynamique démographique remar- quable, dans sa périphérie orientale - composé de l'ensemble Sahel-. Mitidja ..... «Etude agro-pédologique de la plaine de la Mitidja». Florin B.; Semoud N. 2010.

  15. régression linéaire multiple

    African Journals Online (AJOL)

    Mots clés: Alcools et phénols – Représentation numérique de la structure chimique – Facteur acentrique – Régression linéaire multiple – Modèle RSP hybride. English Title: Structure / acentric factor relationship of alcohols and phenols: genetic algorithm – multiple linear regression approach. English Abstract. The acentric ...

  16. A Dynamic Attitude Measurement System Based on LINS

    Directory of Open Access Journals (Sweden)

    Hanzhou Li

    2014-08-01

    Full Text Available A dynamic attitude measurement system (DAMS is developed based on a laser inertial navigation system (LINS. Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG. The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min.

  17. A Dynamic Attitude Measurement System Based on LINS

    Science.gov (United States)

    Li, Hanzhou; Pan, Quan; Wang, Xiaoxu; Zhang, Juanni; Li, Jiang; Jiang, Xiangjun

    2014-01-01

    A dynamic attitude measurement system (DAMS) is developed based on a laser inertial navigation system (LINS). Three factors of the dynamic attitude measurement error using LINS are analyzed: dynamic error, time synchronization and phase lag. An optimal coning errors compensation algorithm is used to reduce coning errors, and two-axis wobbling verification experiments are presented in the paper. The tests indicate that the attitude accuracy is improved 2-fold by the algorithm. In order to decrease coning errors further, the attitude updating frequency is improved from 200 Hz to 2000 Hz. At the same time, a novel finite impulse response (FIR) filter with three notches is designed to filter the dither frequency of the ring laser gyro (RLG). The comparison tests suggest that the new filter is five times more effective than the old one. The paper indicates that phase-frequency characteristics of FIR filter and first-order holder of navigation computer constitute the main sources of phase lag in LINS. A formula to calculate the LINS attitude phase lag is introduced in the paper. The expressions of dynamic attitude errors induced by phase lag are derived. The paper proposes a novel synchronization mechanism that is able to simultaneously solve the problems of dynamic test synchronization and phase compensation. A single-axis turntable and a laser interferometer are applied to verify the synchronization mechanism. The experiments results show that the theoretically calculated values of phase lag and attitude error induced by phase lag can both match perfectly with testing data. The block diagram of DAMS and physical photos are presented in the paper. The final experiments demonstrate that the real-time attitude measurement accuracy of DAMS can reach up to 20″ (1σ) and the synchronization error is less than 0.2 ms on the condition of three axes wobbling for 10 min. PMID:25177802

  18. lin-12 Notch functions in the adult nervous system of C. elegans

    Directory of Open Access Journals (Sweden)

    Tucey Tim M

    2005-07-01

    Full Text Available Abstract Background Notch signaling pathways are conserved across species and traditionally have been implicated in cell fate determination during embryonic development. Notch signaling components are also expressed postdevelopmentally in the brains of adult mice and Drosophila. Recent studies suggest that Notch signaling may play a role in the physiological, rather than developmental, regulation of neurons. Here, we investigate a new non-developmental role for Caenorhabditis elegans lin-12 Notch signaling in neurons regulating the spontaneous reversal rate during locomotion. Results The spontaneous reversal rate of C. elegans during normal locomotion is constant. Both lin-12 gain and loss of function mutant animals had significantly increased reversal rates compared to wild type controls. These defects were caused by lin-12 activity, because the loss of function defect could be rescued by a wild type lin-12 transgene. Furthermore, overexpression of lin-12 recapitulated the gain-of-function defect. Increasing or decreasing lin-12 activity in the postdevelopmental adult animal was sufficient to rapidly and reversibly increase reversals, thereby excluding a developmental role for lin-12. Although lin-12 is expressed in the vulval and somatic gonad lineages, we find that these tissues play no role in regulating reversal rates. In contrast, altering lin-12 activity specifically in the nervous system was sufficient to increase reversals. These behavioral changes require components of the canonical lin-12 signaling cascade, including the ligand lag-2 and the transcriptional effector lag-1. Finally, the C. elegans AMPA/kainate glutamate receptor homolog glr-1 shows strong genetic interactions with lin-12, suggesting that glr-1 and/or other glutamate gated channels may be targets of lin-12 regulation. Conclusion Our results demonstrate a neuronal role for lin-12 Notch in C. elegans and suggest that lin-12 acutely regulates neuronal physiology to

  19. MYCN-driven regulatory mechanisms controlling LIN28B in neuroblastoma

    Science.gov (United States)

    Beckers, Anneleen; Van Peer, Gert; Carter, Daniel R.; Gartlgruber, Moritz; Herrmann, Carl; Agarwal, Saurabh; Helsmoortel, Hetty H.; Althoff, Kristina; Molenaar, Jan J.; Cheung, Belamy B.; Schulte, Johannes H.; Benoit, Yves; Shohet, Jason M.; Westermann, Frank; Marshall, Glenn M.; Vandesompele, Jo; De Preter, Katleen; Speleman, Frank

    2016-01-01

    LIN28B has been identified as an oncogene in various tumor entities, including neuroblastoma, a childhood cancer that originates from neural crest-derived cells, and is characterized by amplification of the MYCN oncogene. Recently, elevated LIN28B expression levels were shown to contribute to neuroblastoma tumorigenesis via let-7 dependent de-repression of MYCN. However, additional insight in the regulation of LIN28B in neuroblastoma is lacking. Therefore, we have performed a comprehensive analysis of the regulation of LIN28B in neuroblastoma, with a specific focus on the contribution of miRNAs. We show that MYCN regulates LIN28B expression in neuroblastoma tumors via two distinct parallel mechanisms. First, through an unbiased LIN28B-3′UTR reporter screen, we found that miR-26a-5p and miR-26b-5p regulate LIN28B expression. Next, we demonstrated that MYCN indirectly affects the expression of miR-26a-5p, and hence regulates LIN28B, therefor establishing a MYCN-miR-26a-5p-LIN28B regulatory axis. Second, we provide evidence that MYCN regulates LIN28B expression via interaction with the LIN28B promotor, establishing a direct MYCN-LIN28B regulatory axis. We believe that these findings mark LIN28B as an important effector of the MYCN oncogenic phenotype and underlines the importance of MYCN-regulated miRNAs in establishing the MYCN-driven oncogenic process. PMID:26123663

  20. Refinements to calandria tube - liquid injection nozzle (CT-LIN) contact assessments

    International Nuclear Information System (INIS)

    Sedran, P.J.

    2012-01-01

    In recent years, the issue of CT-LIN contact, which first gained attention in 1989, has been addressed through CT-LIN gap measurements, followed by analytical predictions of time-to-contact. CT-LIN time-to-contact predictions have been preformed independently by CPUS Limited for Point Lepreau and Gentilly-2 and by AECL Sheridan Park (now Candu Energy Inc.) for Bruce Power and Gentilly-2. Both companies used the CDEPTH code in combination with CT-LIN gap measurements. Subsequent to the assessments for Point Lepreau and Gentilly-2, a recommended approach for future assessments was presented at the 2008 CANDU maintenance conference. Since that time, a number of refinements to the overall strategy for predicting CT-LIN time-to-contact have been developed and are outlined in this paper. The refinements include: 1. The use of ultrasonic LIN elevation measurements to confirm LIN creep sag behaviour 2. The development of a non-linear empirical CT Creep Sag Model 3. The development of a rationale for discrepancies observed in repeated optical CT-LIN gap measurements and a discussion of alternative CT-LIN gap measurements With these refinements, more accurate CT-LIN time-to-contact predictions can be obtained. For stations that plan to refurbish by 210,000 EFPH, the improvement in time-to-contact predictions resulting from the fore mentioned refinements will not be of any real benefit.. However, for stations that are planning life extensions in order to operate beyond 210,000 EFPH, CT-LIN contact will be an issue. For these stations, improvements in CT-LIN contact time predictions would be beneficial. This paper presents a summary of the proposed refinements and demonstrates how they would impact CT-LIN time-to-contact predictions. (author)

  1. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models

    Science.gov (United States)

    Nguyen, Liem H.; Robinton, Daisy A.; Seligson, Marc; Wu, Linwei; Li, Lin; Rakheja, Dinesh; Comerford, Sarah; Ramezani, Saleh; Sun, Xiankai; Parikh, Monisha; Yang, Erin; Powers, John T.; Shinoda, Gen; Shah, Samar; Hammer, Robert; Daley, George Q.; Zhu, Hao

    2014-01-01

    SUMMARY Lin28a/b are RNA-binding proteins that influence stem cell maintenance, metabolism, and oncogenesis. Poorly differentiated, aggressive cancers often overexpress Lin28, but its role in tumor initiation or maintenance has not been definitively addressed. We report that LIN28B overexpression is sufficient to initiate hepatoblastoma and hepatocellular carcinoma in murine models. We also detected Lin28b overexpression in MYC-driven hepatoblastomas, and liver-specific deletion of Lin28a/b reduced tumor burden, extended latency, and prolonged survival. Both intravenous siRNA against Lin28b and conditional Lin28b deletion reduced tumor burden and prolonged survival. Igf2bp proteins are upregulated and Igf2bp3 is required in the context of LIN28B overexpression to promote growth. Thus, multiple murine models demonstrate that Lin28b is both sufficient to initiate liver cancer and necessary for its maintenance. PMID:25117712

  2. Metabolomics of hexachlorocyclohexane (HCH) transformation: ratio of LinA to LinB determines metabolic fate of HCH isomers.

    Science.gov (United States)

    Geueke, Birgit; Garg, Nidhi; Ghosh, Sneha; Fleischmann, Thomas; Holliger, Christof; Lal, Rup; Kohler, Hans-Peter E

    2013-04-01

    Although the production and use of technical hexachlorocyclohexane (HCH) and lindane (the purified insecticidal isomer γ-HCH) are prohibited in most countries, residual concentrations still constitute an immense environmental burden. Many studies describe the mineralization of γ-HCH by bacterial strains under aerobic conditions. However, the metabolic fate of the other HCH isomers is not well known. In this study, we investigated the transformation of α-, β-, γ-, δ-, ε-HCH, and a heptachlorocyclohexane isomer in the presence of varying ratios of the two enzymes that initiate γ-HCH degradation, a dehydrochlorinase (LinA) and a haloalkane dehalogenase (LinB). Each substrate yielded a unique metabolic profile that was strongly dependent on the enzyme ratio. Comparison of these results to those of in vivo experiments with different bacterial isolates showed that HCH transformation in the tested strains was highly optimized towards productive metabolism of γ-HCH and that under these conditions other HCH-isomers were metabolized to mixtures of dehydrochlorinated and hydroxylated side-products. In view of these results, bioremediation efforts need very careful planning and toxicities of accumulating metabolites need to be evaluated. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

  3. Fetal deficiency of Lin28 programs life-long aberrations in growth and glucose metabolism

    Science.gov (United States)

    Shinoda, Gen; Shyh-Chang, Ng; de Soysa, T. Yvanka; Zhu, Hao; Seligson, Marc T.; Shah, Samar P.; Abo-Sido, Nora; Yabuuchi, Akiko; Hagan, John P.; Gregory, Richard I.; Asara, John M.; Cantley, Lewis C.; Moss, Eric G.; Daley, George Q.

    2013-01-01

    LIN28A/B are RNA binding proteins implicated by genetic association studies in human growth and glucose metabolism. Mice with ectopic over-expression of Lin28a have shown related phenotypes. Here we describe the first comprehensive analysis of the physiologic consequences of Lin28a and Lin28b deficiency in knockout (KO) mice. Lin28a/b-deficiency led to dwarfism starting at different ages, and compound gene deletions showed a cumulative dosage effect on organismal growth. Conditional gene deletion at specific developmental stages revealed that fetal but neither neonatal nor adult deficiency resulted in growth defects and aberrations in glucose metabolism. Tissue-specific KO mice implicated skeletal muscle-deficiency in the abnormal programming of adult growth and metabolism. The effects of Lin28b KO can be rescued by Tsc1 haplo-insufficiency in skeletal muscles. Our data implicate fetal expression of Lin28a/b in the regulation of life-long effects on metabolism and growth, and demonstrate that fetal Lin28b acts at least in part via mTORC1 signaling. PMID:23666760

  4. Importance of the pluripotency factor LIN28 in the mammalian nucleolus during early embryonic development.

    Science.gov (United States)

    Vogt, Edgar J; Meglicki, Maciej; Hartung, Kristina Ilka; Borsuk, Ewa; Behr, Rüdiger

    2012-12-01

    The maternal nucleolus is required for proper activation of the embryonic genome (EGA) and early embryonic development. Nucleologenesis is characterized by the transformation of a nucleolar precursor body (NPB) to a mature nucleolus during preimplantation development. However, the function of NPBs and the involved molecular factors are unknown. We uncover a novel role for the pluripotency factor LIN28, the biological significance of which was previously demonstrated in the reprogramming of human somatic cells to induced pluripotent stem (iPS) cells. Here, we show that LIN28 accumulates at the NPB and the mature nucleolus in mouse preimplantation embryos and embryonic stem cells (ESCs), where it colocalizes with the nucleolar marker B23 (nucleophosmin 1). LIN28 has nucleolar localization in non-human primate (NHP) preimplantation embryos, but is cytoplasmic in NHP ESCs. Lin28 transcripts show a striking decline before mouse EGA, whereas LIN28 protein localizes to NPBs at the time of EGA. Following knockdown with a Lin28 morpholino, the majority of embryos arrest between the 2- and 4-cell stages and never develop to morula or blastocyst. Lin28 morpholino-injected embryos arrested at the 2-cell stage were not enriched with nucleophosmin at presumptive NPB sites, indicating that functional NPBs were not assembled. Based on these results, we propose that LIN28 is an essential factor of nucleologenesis during early embryonic development.

  5. 107 Définition structurale des linéaments par traitement d'image ...

    African Journals Online (AJOL)

    Valued Packard Bell Customer

    The Ngovayang massif represents a key domain in understanding the geodynamics of the northern border of the Congo craton in South Cameroon. Remote sensing works .... linéaments liés au socle rocheux et aux accidents tectoniques (Minyem, 1994 [2]). Ces linéaments sont repartis selon trois directions. - la direction ...

  6. Regulation of C. elegans L4 cuticle collagen genes by the heterochronic protein LIN-29.

    Science.gov (United States)

    Abete-Luzi, Patricia; Eisenmann, David M

    2018-05-01

    The cuticle, the outer covering of the nematode C. elegans, is synthesized five times during the worm's life by the underlying hypodermis. Cuticle collagens, the major cuticle component, are encoded by a large family of col genes and, interestingly, many of these genes express predominantly at a single developmental stage. This temporal preference motivated us to investigate the mechanisms underlying col gene expression and here we focus on a subset of col genes expressed in the L4 stage. We identified minimal promoter regions of <300 bp for col-38, col-49, and col-63. In these regions, we predicted cis-regulatory sequences and evaluated their function in vivo via mutagenesis of a col-38p::yfp reporter. We used RNAi to study the requirement for candidate transcription regulators ELT-1 and ELT-3, LIN-29, and the LIN-29 co-factor MAB-10, and found LIN-29 to be necessary for the expression of four L4-specific genes (col-38, col-49, col-63, and col-138). Temporal misexpression of LIN-29 was also sufficient to activate these genes at a different developmental stage. The LIN-29 DNA-binding domain bound the col-38, col-49, and col-63 minimal promoters in vitro. For col-38 we showed that the LIN-29 sites necessary for reporter expression in vivo are also bound in vitro: this is the first identification of specific binding sites for LIN-29 necessary for in vivo target gene expression. © 2018 Wiley Periodicals, Inc.

  7. In vitro expansion of Lin+ and Lin− mononuclear cells from human peripheral blood

    International Nuclear Information System (INIS)

    Norhaiza, H. Siti; Zarina, Z. A. Intan; Hisham, Z. A. Shahrul; Rohaya, M. A. W.

    2013-01-01

    Haematopoietic stem cells (HSCs) are used in the therapy of blood disorders due to the ability of these cells to reconstitute haematopoietic lineage cells when transplanted into myeloablative recipients. However, substantial number of cells is required in order for the reconstitution to take place. Since HSCs present in low frequency, larger number of donor is required to accommodate the demand of transplantable HSCs. Therefore, in vitro expansion of HSCs will have profound impact on clinical purposes. The aim of this study was to expand lineage negative (Lin − ) stem cells from human peripheral blood. Total peripheral blood mononuclear cells (PBMNCs) were fractionated from human blood by density gradient centrifugation. Subsequently, PBMNCs were subjected to magnetic assisted cell sorter (MACS) which depletes lineage positive (Lin + ) mononuclear cells expressing lineage positive markers such as CD2, CD3, CD11b, CD14, CD15, CD16, CD19, CD56, CD123, and CD235a to obtained Lin − cell population. The ability of Lin + and Lin − to survive in vitro was explored by culturing both cell populations in complete medium consisting of Alpha-Minimal Essential Medium (AMEM) +10% (v/v) Newborn Calf Serum (NBCS)+ 2% (v/v) pen/strep. In another experiment, Lin + and Lin − were cultured with complete medium supplemented with 10ng/mL of the following growth factors: stem cell factor (SCF), interleukin (IL)-3, granulocyte-macrophage colony stimulating factor (GM-CSF), 2IU/mL of Erythropoietin (Epo) and 20ng/mL of IL-6. Three samples were monitored in static culture for 22 days. The expansion potential was assessed by the number of total viable cells, counted by trypan blue exclusion assay. It was found that Lin + mononuclear cells were not able to survive either in normal proliferation medium or proliferation medium supplemented with cytokines. Similarly, Lin − stem cells were not able to survive in proliferation medium however, addition of cytokines into the proliferation

  8. Lin Receives 2010 Natural Hazards Focus Group Award for Graduate Research

    Science.gov (United States)

    2010-11-01

    Ning Lin has been awarded the Natural Hazards Focus Group Award for Graduate Research, given annually to a recent Ph.D. recipient for outstanding contributions to natural hazards research. Lin's thesis is entitled “Multi-hazard risk analysis related to hurricanes.” She is scheduled to present an invited talk in the Extreme Natural Events: Modeling, Prediction, and Mitigation session (NH20) during the 2010 AGU Fall Meeting, held 13-17 December in San Francisco, Calif. Lin will be formally presented with the award at the Natural Hazards focus group reception on 14 December 2010.

  9. Lin28 Mediates Cancer Chemotherapy Resistance via Regulation of miRNA Signaling.

    Science.gov (United States)

    Xu, Chaoyang; Xie, Shuduo; Song, Chunjiao; Huang, Liming; Jiang, Zhinong

    2014-06-01

    Chemotherapy resistance is one of the major obstacles limiting the success of cancer drug treatment. Among the mechanisms of resistance to chemotherapy treatment, there are those closely related to P-Glycoprotein, multidrug resistance-related protein, glutathione S-transferase pi and topoisomerase-II. Lin28 is a highly conserved RNA-binding protein, it consists of a cold shock domain and retroviral-type (CCHC) zinc finger motifs. In previous preclinical and clinical studies, positive Lin28 expression in cancer cells was correlated with decreased sensitivity to chemotherapy. And Lin28 could mediate cancer chemotherapy resistance via regulation of miR107 and Let-7 MiRNA. This article reviews current knowledge on predictive value of Lin28 in response to chemotherapy. Better understanding of its role may facilitate patient's selection of therapeutic regimen and lead to optimal clinical outcome.

  10. Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Wang, Yi, E-mail: wangyieye@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Xu, Haiwei, E-mail: haiweixu2001@163.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China); Yin, Zheng Qin, E-mail: qinzyin@aliyun.com [Southwest Hospital/Southwest Eye Hospital, Third Military Medical University, Chongqing 400038 (China); Key Lab of Visual Damage and Regeneration & Restoration of Chongqing, Chongqing 400038 (China)

    2017-03-01

    In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

  11. Lin28b stimulates the reprogramming of rat Müller glia to retinal progenitors

    International Nuclear Information System (INIS)

    Zhao, Chen; Tao, Zui; Xue, Langyue; Zeng, Yuxiao; Wang, Yi; Xu, Haiwei; Yin, Zheng Qin

    2017-01-01

    In lower-order vertebrates, Müller glia exhibit characteristics of retinal progenitor cells, while in higher vertebrates, such as mammals, the regenerative capacity of Müller glia is limited. Recently, we reported that Lin28b promoted the trans-differentiation of Müller cells to rod photoreceptor and bipolar cells in the retina of retinitis pigmentosa rat model, whereas it is unclear whether Lin28b can stimulate the reprogramming of Müller glia in vitro for transplantation into a damaged retina. In the present study, Long-Evens rat Müller glia were infected with Adeno-Lin28b or Adeno-GFP. Over-expression of Lin28b in isolated rat Müller glia resulted in the suppression of GFAP expression, enhancement of cell proliferation and a significant increase of the expression of retinal progenitor markers 5 days after infection. Moreover, Lin28b caused a significant reduction of the Let-7 family of microRNAs. Following sub-retinal space transplantation, Müller glia-derived retinal progenitors improved b-wave amplification of 30d Royal College of Surgeons retinitis pigmentosa model (RCS-P+) rats, as detected by electroretinography (ERG) recordings. Taken together, these data suggest that the up-regulation of Lin28b expression facilitated the reprogramming of Müller cells toward characteristics of retinal progenitors. - Highlights: • Lin28b reprograms Müller glia to retinal progenitors. • Let-7 micrRNAs are suppressed by Lin28b. • Transplantation of reprogrammed Müller glia restores retinal function.

  12. Le nævus épidermique verruqueux inflammatoire linéaire ...

    African Journals Online (AJOL)

    Le nævus épidermique verruqueux inflammatoire linéaire (NEVIL) est une affection rare correspondant à des hyperplasies épidermiques bénignes qui se présentent cliniquement sous forme de lésions linéaires unilatérales hyperkératosiques. Une adolescente âgée de 16 ans, sans antécédents, présentait depuis la ...

  13. Association of Lin-28A rs3811464 Variant with Susceptibility to Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Mona Khodabandeh

    2017-11-01

    Full Text Available Introduction: It has been suggested that Lin-28A and the let-7 microRNA family (Lin-28/let-7 axis play a critical role in the control of glucose metabolism, insulin sensitivity and resistance to diabetes. Aim: This case-control study aimed at evaluating the association between Lin-28 rs3811464 polymorphism and the susceptibility to Type 2 Diabetes (T2D in a sample of Iranian population. Materials and Methods: This study involved 172 T2D patients and 160 non-diabetic age and gender-matched controls. Lin 28A rs3811464 genotypes were determined by Polymerase Chain Reaction–Restriction Fragment Length Polymorphism (PCR-RFLP technique. Results: The results showed that the frequency of the AA genotype was significantly higher in control subjects than in diabetic patients (13.12% vs. 4.65%. In addition, binary logistic regression analysis revealed that rs3811464-AA genotype was significantly associated to T2D after adjustment for BMI, age and lipid profiles. Indeed, subjects with AA genotype were less likely to develop T2D than GG and AG subjects (OR of 0.26, 95% CI 0.10-0.66, p=0.005. Conclusion: The findings of our study suggest that the Lin 28A rs3811464 is associated with type 2 diabetes susceptibility and subjects with AA genotypes were less likely to develop T2D diabetes.

  14. Clinical application of Lin's biopsy grasper for intrauterine targeted biopsy and polypectomy during office hysteroscopy.

    Science.gov (United States)

    Cheng, Hsin-Yi; Lin, Bao-Liang; Tseng, Jen-Yu; Ueno, Kazunori; Nakada, Sakura

    2018-06-01

    Hysteroscopy has widely been used for diagnosis of the uterine cavity; however, target biopsy has often been difficult in part to the inherent limitations of ancillary instruments. Lin's biopsy grasper was specifically designed to work in conjunction with a flexible hysteroscope to obtain intrauterine biopsy under transabdominal sonography. Herein, we share our clinical experience in the management of endometrial abnormalities with the use of Lin's biopsy grasper during office-based hysteroscopy. From February 2006 to November 2016, the use of Lin's biopsy grasper for tissue biopsy was attempted on 126 cases. We retrospectively recorded and analyzed the patients' preoperative characteristics and biopsy outcomes to demonstrate the feasibility and efficacy of Lin's biopsy grasper. Out of the one hundred and twenty-six enrolled patients, satisfactory targeted biopsies were achieved; including high diagnostic rate (92.1%, with 116 cases confirmed histologically) and adequate tissue retrieval (77.8%, with 98 cases obtaining optimal specimen volume). All patients tolerated the procedure without analgesics or anesthesia. Diagnostic flexible hysteroscopy combined with the use of Lin's biopsy grasper has proven to be an effective tool for intrauterine evaluation and obtaining tissue sample. Copyright © 2018. Published by Elsevier B.V.

  15. Lin4Neuro: a customized Linux distribution ready for neuroimaging analysis.

    Science.gov (United States)

    Nemoto, Kiyotaka; Dan, Ippeita; Rorden, Christopher; Ohnishi, Takashi; Tsuzuki, Daisuke; Okamoto, Masako; Yamashita, Fumio; Asada, Takashi

    2011-01-25

    A variety of neuroimaging software packages have been released from various laboratories worldwide, and many researchers use these packages in combination. Though most of these software packages are freely available, some people find them difficult to install and configure because they are mostly based on UNIX-like operating systems. We developed a live USB-bootable Linux package named "Lin4Neuro." This system includes popular neuroimaging analysis tools. The user interface is customized so that even Windows users can use it intuitively. The boot time of this system was only around 40 seconds. We performed a benchmark test of inhomogeneity correction on 10 subjects of three-dimensional T1-weighted MRI scans. The processing speed of USB-booted Lin4Neuro was as fast as that of the package installed on the hard disk drive. We also installed Lin4Neuro on a virtualization software package that emulates the Linux environment on a Windows-based operation system. Although the processing speed was slower than that under other conditions, it remained comparable. With Lin4Neuro in one's hand, one can access neuroimaging software packages easily, and immediately focus on analyzing data. Lin4Neuro can be a good primer for beginners of neuroimaging analysis or students who are interested in neuroimaging analysis. It also provides a practical means of sharing analysis environments across sites.

  16. LIN-32/Atonal Controls Oxygen Sensing Neuron Development in Caenorhabditis elegans

    DEFF Research Database (Denmark)

    Romanos, Teresa Rojo; Pladevall-Morera, David; Langebeck-Jensen, Kasper

    2017-01-01

    HLH) family of transcription factors has multiple functions in neurogenesis. Here, we identified the LIN-32/Atonal bHLH transcription factor as a key regulator of URXL/R oxygen-sensing neuron development in Caenorhabditis elegans. When LIN-32/Atonal expression is lost, the expression of URX specification......Development of complex nervous systems requires precisely controlled neurogenesis. The generation and specification of neurons occur through the transcriptional and post-Transcriptional control of complex regulatory networks. In vertebrates and invertebrates, the proneural basic-helix-loop-helix (b...... and terminal differentiation genes is abrogated. As such, lin-32 mutant animals are unable to respond to increases in environmental oxygen. The URX neurons are generated from a branch of the cell lineage that also produces the CEPDL/R and URADL/R neurons. We found development of these neurons is also defective...

  17. Identification and Characterization of Genes That Interact with Lin-12 in Caenorhabditis Elegans

    OpenAIRE

    Tax, F. E.; Thomas, J. H.; Ferguson, E. L.; Horvitz, H. R.

    1997-01-01

    We identified and characterized 14 extragenic mutations that suppressed the dominant egg-laying defect of certain lin-12 gain-of-function mutations. These suppressors defined seven genes: sup-17, lag-2, sel-4, sel-5, sel-6, sel-7 and sel-8. Mutations in six of the genes are recessive suppressors, whereas the two mutations that define the seventh gene, lag-2, are semi-dominant suppressors. These suppressor mutations were able to suppress other lin-12 gain-of-function mutations. The suppressor ...

  18. [Professor LIN Guohua's experience of gold implantation at acupoint for rheumatoid arthritis].

    Science.gov (United States)

    Li, Jingjing; Pei, Wenya

    2015-12-01

    Based on the pathogenesis and symptom of rheumatoid arthritis (RA), professor LIN Guohua's unique opinion and method for RA in clinical treatment are summarized and analyzed. In the opinion of Professor Lin, RA is considered as "Jinbi" and "Gubi" in TCM, which is caused by deficient root with superficial excess. Based on the symptoms of RA, attention should be focused on lung-kidney diagnosis and treatment, and gold and catgut implantation at acupoint can be mutually combined, which is aimed to provide a special and effective method for clinical treatment of RA.

  19. Multiple transcription factors directly regulate Hox gene lin-39 expression in ventral hypodermal cells of the C. elegans embryo and larva, including the hypodermal fate regulators LIN-26 and ELT-6.

    Science.gov (United States)

    Liu, Wan-Ju; Reece-Hoyes, John S; Walhout, Albertha J M; Eisenmann, David M

    2014-05-13

    Hox genes encode master regulators of regional fate specification during early metazoan development. Much is known about the initiation and regulation of Hox gene expression in Drosophila and vertebrates, but less is known in the non-arthropod invertebrate model system, C. elegans. The C. elegans Hox gene lin-39 is required for correct fate specification in the midbody region, including the Vulval Precursor Cells (VPCs). To better understand lin-39 regulation and function, we aimed to identify transcription factors necessary for lin-39 expression in the VPCs, and in particular sought factors that initiate lin-39 expression in the embryo. We used the yeast one-hybrid (Y1H) method to screen for factors that bound to 13 fragments from the lin-39 region: twelve fragments contained sequences conserved between C. elegans and two other nematode species, while one fragment was known to drive reporter gene expression in the early embryo in cells that generate the VPCs. Sixteen transcription factors that bind to eight lin-39 genomic fragments were identified in yeast, and we characterized several factors by verifying their physical interactions in vitro, and showing that reduction of their function leads to alterations in lin-39 levels and lin-39::GFP reporter expression in vivo. Three factors, the orphan nuclear hormone receptor NHR-43, the hypodermal fate regulator LIN-26, and the GATA factor ELT-6 positively regulate lin-39 expression in the embryonic precursors to the VPCs. In particular, ELT-6 interacts with an enhancer that drives GFP expression in the early embryo, and the ELT-6 site we identified is necessary for proper embryonic expression. These three factors, along with the factors ZTF-17, BED-3 and TBX-9, also positively regulate lin-39 expression in the larval VPCs. These results significantly expand the number of factors known to directly bind and regulate lin-39 expression, identify the first factors required for lin-39 expression in the embryo, and hint at a

  20. Nomenclatural Studies Toward a World List of Diptera Genus-Group Names. Part V: Pierre-Justin-Marie Macquart.

    Science.gov (United States)

    Evenhuis, Neal L; Pape, Thomas; Pont, Adrian C

    2016-09-30

    The Diptera genus-group names of Pierre-Justin-Marie Macquart are reviewed and annotated. A total of 399 available genus-group names in 69 families of Diptera are listed alphabetically, for each name giving author, year and page of original publication, originally included species, type species and method of fixation, current status of the name, family placement, and a list of any emendations of it that have been found in the literature. Remarks are given to clarify nomenclatural or taxonomic information. In addition, an index to all the species-group names of Diptera proposed by Macquart (3,611, of which 3,543 are available) is given with bibliographic reference (year and page) to each original citation.        The following type species are designated herein: Agculocera nigra Macquart, 1855 for Onuxicera Macquart, 1855, present designation [Tachinidae]; Trixa imhoffi Macquart, 1834, for Semiomyia Macquart, 1848, present designation [Tachinidae].        The following type species are designated herein with fixation under ICZN Code Art. 70.3.2: Azelia nebulosa Robineau-Desvoidy, 1830 for Atomogaster Macquart, 1835, present designation [Muscidae]; Tachydromia vocatoria Fallén, 1816 for Chelipoda Macquart, 1835, present designation [Empididae]; Eriocera macquarti Enderlein, 1912 for Eriocera Macquart, 1838, present designation [Limoniidae]; Limosina acutangula Zetterstedt, 1847 for Heteroptera Macquart, 1835, present designation [Sphaeroceridae]; Phryxe pavoniae Robineau-Desvoidy, 1830 for Masicera Macquart, 1834, present designation [Tachinidae]; Pachymyia macquartii Townsend, 1916 for Pachymyia Macquart, 1844, present designation [Tachinidae].        Earlier valid subsequent type-species designations have been found in this study for the following: Anisophysa Macquart, 1835 [Sepsidae]; Diphysa Macquart, 1838 [Stratiomyidae]; Pachyrhina Macquart, 1834 [Tipulidae]; Silbomyia Macquart, 1844 [Calliphoridae].        One name is raised from

  1. Kinetic and sequence-structure-function analysis of known LinA variants with different hexachlorocyclohexane isomers.

    Directory of Open Access Journals (Sweden)

    Pooja Sharma

    Full Text Available BACKGROUND: Here we report specific activities of all seven naturally occurring LinA variants towards three different isomers, α, γ and δ, of a priority persistent pollutant, hexachlorocyclohexane (HCH. Sequence-structure-function differences contributing to the differences in their stereospecificity for α-, γ-, and δ-HCH and enantiospecificity for (+- and (--α -HCH are also discussed. METHODOLOGY/PRINCIPAL FINDINGS: Enzyme kinetic studies were performed with purified LinA variants. Models of LinA2(B90A A110T, A111C, A110T/A111C and LinA1(B90A were constructed using the FoldX computer algorithm. Turnover rates (min(-1 showed that the LinAs exhibited differential substrate affinity amongst the four HCH isomers tested. α-HCH was found to be the most preferred substrate by all LinA's, followed by the γ and then δ isomer. CONCLUSIONS/SIGNIFICANCE: The kinetic observations suggest that LinA-γ1-7 is the best variant for developing an enzyme-based bioremediation technology for HCH. The majority of the sequence variation in the various linA genes that have been isolated is not neutral, but alters the enantio- and stereoselectivity of the encoded proteins.

  2. Analisis Kebutuhan Bandwidth Pada Pemanfaatan Web Streaming Justin.tv Sebagai Media E-Learning Dengan Menggunakan Wirecast Dan Desktop Presenter

    Directory of Open Access Journals (Sweden)

    Muhammad Ubaidilah

    2014-05-01

    Full Text Available Perkembangan teknologi informasi begitu cepat seperti sekarang telah banyak mengubah sudut pandang banyak orang, antara lain sudut pandang orang untuk mengubah dunia pendidikan menjadi lebih baik. Salah satu contohnya pembelajaran berbasis Information and Communication Technologies (ICT yaitu pembelajaran menggunakan video streaming. Dengan instalasi software open source Wirecast dan Desktop presenter digunakan untuk membuat video pembelajaran Streaming, disiarkan secara real time melalui media broadcast justin.tv (internet TV Channel, diharapkan dapat lebih mendukung konsep pembelajaran kapan dan dimana saja. Masalah terbesar dari teknologi ini adalah keterbatasan bandwidth. Bandwidth adalah parameter penting untuk melakukan streaming dalam jaringan. Sedangkan proses komunikasi menggunakan video digital ini menghabiskan resource yang cukup besar. Sehingga penggunaan wireshark di sini sangat diperlukan untuk menganalisis bandwidth pada paket yang diterima oleh client. Dari hasil pengukuran video dengan standar H.264 resolusi (720 x 540, dengan rata-rata 20 menit dalam pengambilan sampel, sebanyak 30 pengujian sampel streaming video menggunakan wireshark, diperoleh rata-rata throughput keseluruhan 0,343 Mbps, rata-rata throughput terendah 0,309 Mbps dan throughput tertinggi 0,372 Mbps. Dapat disimpulkan bahwa jika dihasilkan throughput yang lebih besar maka kualitas video streaming akan lebih baik, tetapi jika throughput dihasilkan semakin kecil maka kualitas video streaming akan menurun

  3. An Effective Implementation of K-opt Moves for the Lin-Kernighan TSP Heuristic

    DEFF Research Database (Denmark)

    Helsgaun, Keld

    Local search with k-change neighborhoods, k-opt, is the most widely used heuristic method for the traveling salesman problem (TSP). This report presents an effective implementation of k-opt for the Lin- Kernighan TSP heuristic. The effectiveness of the implementation is demonstrated with extensive...

  4. Combustion of Pure, Hydrolyzed and Methyl Ester Formed of Jatropha Curcas Lin oil

    Directory of Open Access Journals (Sweden)

    Muhaji Muhaji

    2015-10-01

    Full Text Available The density and viscosity of vegetable oil are higher than that of diesel oil. Thus its direct combustion in the diesel engine results many problems. This research was conducted to investigate the flame characteristics of combustion of jatropha curcas lin in pure, hydrolyzed and methyl ester form. The results indicated that the combustion of pure jatropha curcas lin occurs in three stages, hydrolyzed in two stages    and methyl ester in one stage. For pure jatropha curcas lin, in the first stage, unsaturated fatty acid burned for  0.265 s.  It is followed by saturated fatty acid, burned for 0.389 s in the second stage. And, in the last stage is the burned of glycerol for 0.560 s. Meanwhile for hydrolyzed one, in the first stage, unsaturated fatty acid burned for 0.736 s, followed by saturated fatty acid, burned  for 0.326 s in the second stage. And the last, for methyl ester is the burned for 0.712 s. The highest burning rate was for methyl ester which was 0.003931cc/s. The energy releasing rate of methyl ester, which was for 13,628.67 kcal/(kg.s resembled that of diesel oil the most, while the lowest rate was for pure jatropha curcas lin which was 8,200.94 kcal/(kg.s. In addition, massive explosion occurred in the fuel containing unsaturated fatty acid and glycerol

  5. linäituse stendid = Outdoor exhibition stands / Gert Sarv, Galina Burnakova

    Index Scriptorium Estoniae

    Sarv, Gert, 1971-

    2013-01-01

    Eesti Sisearhitektide Liidu 2012. aasta parima eseme preemia pälvinud välinäituse stendidest Vanasadama Admiraliteedi basseini kaldapealsel. Autorid: Gert Sarv, Galina Burnakova, Loreida Hein. Sisearhitekti ja ESLi aastapreemiate žürii liikme Tea Tammelaane arvamus

  6. A role for Lin28 in primordial germ cell development and germ cell malignancy

    Science.gov (United States)

    West, Jason A.; Viswanathan, Srinivas R.; Yabuuchi, Akiko; Cunniff, Kerianne; Takeuchi, Ayumu; Park, In-Hyun; Sero, Julia E.; Zhu, Hao; Perez-Atayde, Antonio; Frazier, A. Lindsay; Surani, M. Azim; Daley, George Q.

    2009-01-01

    The rarity and inaccessibility of the earliest primordial germ cells (PGCs) in the mouse embryo thwarts efforts to investigate molecular mechanisms of germ cell specification. Stella marks the minute founder population of the germ lineage1,2. Here we differentiate mouse embryonic stem cells (ESCs) carrying a Stella transgenic reporter into putative PGCs in vitro. The Stella+ cells possess a transcriptional profile similar to embryo-derived PGCs, and like their counterparts in vivo, lose imprints in a time-dependent manner. Using inhibitory RNAs to screen candidate genes for effects on the development of Stella+ cells in vitro, we discovered that Lin28, a negative regulator of let-7 microRNA processing3-6, is essential for proper PGC development. We further show that Blimp1, a let-7 target and a master regulator of PGC specification7-9, can rescue the effect of Lin28-deficiency during PGC development, thereby establishing a mechanism of action for Lin28 during PGC specification. Over-expression of Lin28 promotes formation of Stella+ cells in vitro and PGCs in chimeric embryos, and is associated with human germ cell tumours. The differentiation of putative PGCs from ESCs in vitro recapitulates the early stages of gamete development in vivo, and provides an accessible system for discovering novel genes involved in germ cell development and malignancy. PMID:19578360

  7. Cryptanalysis of Lin et al.'s Efficient Block-Cipher-Based Hash Function

    NARCIS (Netherlands)

    Liu, Bozhong; Gong, Zheng; Chen, Xiaohong; Qiu, Weidong; Zheng, Dong

    2010-01-01

    Hash functions are widely used in authentication. In this paper, the security of Lin et al.'s efficient block-cipher-based hash function is reviewed. By using Joux's multicollisions and Kelsey et al.'s expandable message techniques, we find the scheme is vulnerable to collision, preimage and second

  8. Single-tube linear DNA amplification (LinDA) for robust ChIP-seq

    NARCIS (Netherlands)

    Shankaranarayanan, P.; Mendoza-Parra, M.A.; Walia, M.; Wang, L.; Li, N.; Trindade, L.M.; Gronemeyer, H.

    2011-01-01

    Genome-wide profiling of transcription factors based on massive parallel sequencing of immunoprecipitated chromatin (ChIP-seq) requires nanogram amounts of DNA. Here we describe a high-fidelity, single-tube linear DNA amplification method (LinDA) for ChIP-seq and reChIP-seq with picogram DNA amounts

  9. New explicit and exact solutions of the Benney–Kawahara–Lin equation

    International Nuclear Information System (INIS)

    Yuan-Xi, Xie

    2009-01-01

    In this paper, we present a combination method of constructing the explicit and exact solutions of nonlinear partial differential equations. And as an illustrative example, we apply the method to the Benney–Kawahara–Lin equation and derive its many explicit and exact solutions which are all new solutions. (general)

  10. Variational principles of fluid mechanics and electromagnetism: imposition and neglect of the Lin constraint

    International Nuclear Information System (INIS)

    Allen, R.R. Jr.

    1987-01-01

    The Lin constraint has been utilized by a number of authors who have sought to develop Eulerian variational principles in both fluid mechanics and electromagnetics (or plasmadynamics). This dissertation first reviews the work of earlier authors concerning the development of variational principles in both the Eulerian and Lagrangian nomenclatures. In the process, it is shown whether or not the Euler-Lagrange equations that result from the variational principles are equivalent to the generally accepted equations of motion. In particular, it is shown in the case of several Eulerian variational principles that imposition of the Lin constraint results in Euler-Lagrange equations equivalent to the generally accepted equations of motion, whereas neglect of the Lin constraint results in restrictive Euler-Lagrange equations. In an effort to improve the physical motivation behind introduction of the Lin constraint, a new variational constraint is developed based on teh concept of surface forces within a fluid. Additionally, it is shown that a quantity often referred to as the canonical momentum of a charged fluid is not always a constant of the motion of the fluid; and it is demonstrated that there does not exist an unconstrained Eulerian variational principle giving rise to the generally accepted equations of motion for both a perfect fluid and a cold, electromagnetic fluid

  11. Biodegradation of γ-hexachlorocyclohexane by transgenic hairy root cultures of Cucurbita moschata that accumulate recombinant bacterial LinA.

    Science.gov (United States)

    Nanasato, Yoshihiko; Namiki, Sayuri; Oshima, Masao; Moriuchi, Ryota; Konagaya, Ken-Ichi; Seike, Nobuyasu; Otani, Takashi; Nagata, Yuji; Tsuda, Masataka; Tabei, Yutaka

    2016-09-01

    γ-HCH was successfully degraded using LinA-expressed transgenic hairy root cultures of Cucurbita moschata . Fusing an endoplasmic reticulum-targeting signal peptide to LinA was essential for stable accumulation in the hairy roots. The pesticide γ-hexachlorocyclohexane (γ-HCH) is a persistent organic pollutant (POP) that raises public health and environmental pollution concerns worldwide. Although several isolates of γ-HCH-degrading bacteria are available, inoculating them directly into γ-HCH-contaminated soil is ineffective because of the bacterial survival rate. Cucurbita species incorporate significant amounts of POPs from soils compared with other plant species. Here, we describe a novel bioremediation strategy that combines the bacterial degradation of γ-HCH and the efficient uptake of γ-HCH by Cucurbita species. We produced transgenic hairy root cultures of Cucurbita moschata that expressed recombinant bacterial linA, isolated from the bacterium Sphingobium japonicum UT26. The LinA protein was accumulated stably in the hairy root cultures by fusing an endoplasmic reticulum (ER)-targeting signal peptide to LinA. Then, we demonstrated that the cultures degraded more than 90 % of γ-HCH (1 ppm) overnight and produced the γ-HCH metabolite 1,2,4-trichlorobenzene, indicating that LinA degraded γ-HCH. These results indicate that the gene linA has high potential for phytoremediation of environmental γ-HCH.

  12. LIN28 phosphorylation by MAPK/ERK couples signaling to the post-transcriptional control of pluripotency

    Science.gov (United States)

    Tsanov, Kaloyan M.; Pearson, Daniel S.; Wu, Zhaoting; Han, Areum; Triboulet, Robinson; Seligson, Marc T.; Powers, John T.; Osborne, Jihan K.; Kane, Susan; Gygi, Steven P.; Gregory, Richard I.; Daley, George Q.

    2016-01-01

    Signaling and post-transcriptional gene control are both critical for the regulation of pluripotency1,2, yet how they are integrated to influence cell identity remains poorly understood. LIN28 (also known as LIN28A), a highly conserved RNA-binding protein (RBP), has emerged as a central post-transcriptional regulator of cell fate through blockade of let-7 microRNA (miRNA) biogenesis and direct modulation of mRNA translation3. Here we show that LIN28 is phosphorylated by MAPK/ERK in pluripotent stem cells (PSCs), which increases its levels via post-translational stabilization. LIN28 phosphorylation had little impact on let-7 but enhanced LIN28’s effect on its direct mRNA targets, revealing a mechanism that uncouples LIN28’s let-7-dependent and independent activities. We have linked this mechanism to the induction of pluripotency by somatic cell reprogramming and the transition from naïve to primed pluripotency. Collectively, our findings indicate that MAPK/ERK directly impacts LIN28, defining an axis that connects signaling, post-transcriptional gene control, and cell fate regulation. PMID:27992407

  13. The let-7/Lin28 axis regulates activation of hepatic stellate cells in alcoholic liver injury.

    Science.gov (United States)

    McDaniel, Kelly; Huang, Li; Sato, Keisaku; Wu, Nan; Annable, Tami; Zhou, Tianhao; Ramos-Lorenzo, Sugeily; Wan, Ying; Huang, Qiaobing; Francis, Heather; Glaser, Shannon; Tsukamoto, Hidekazu; Alpini, Gianfranco; Meng, Fanyin

    2017-07-07

    The let-7/Lin28 axis is associated with the regulation of key cellular regulatory genes known as microRNAs in various human disorders and cancer development. This study evaluated the role of the let-7/Lin28 axis in regulating a mesenchymal phenotype of hepatic stellate cells in alcoholic liver injury. We identified that ethanol feeding significantly down-regulated several members of the let-7 family in mouse liver, including let-7a and let-7b. Similarly, the treatment of human hepatic stellate cells (HSCs) with lipopolysaccharide (LPS) and transforming growth factor-β (TGF-β) significantly decreased the expressions of let-7a and let-7b. Conversely, overexpression of let-7a and let-7b suppressed the myofibroblastic activation of cultured human HSCs induced by LPS and TGF-β, as evidenced by repressed ACTA2 (α-actin 2), COL1A1 (collagen 1A1), TIMP1 (TIMP metallopeptidase inhibitor 1), and FN1 (fibronectin 1); this supports the notion that HSC activation is controlled by let-7. A combination of bioinformatics, dual-luciferase reporter assay, and Western blot analysis revealed that Lin28B and high-mobility group AT-hook (HMGA2) were the direct targets of let-7a and let-7b. Furthermore, Lin28B deficiency increased the expression of let-7a/let-7b as well as reduced HSC activation and liver fibrosis in mice with alcoholic liver injury. This feedback regulation of let-7 by Lin28B is verified in hepatic stellate cells isolated by laser capture microdissection from the model. The identification of the let-7/Lin28 axis as an important regulator of HSC activation as well as its upstream modulators and down-stream targets will provide insights into the involvement of altered microRNA expression in contributing to the pathogenesis of alcoholic liver fibrosis and novel therapeutic approaches for human alcoholic liver diseases. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  14. Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively

    OpenAIRE

    Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

    2017-01-01

    Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3’-5’ exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We presen...

  15. Fragmented Encounters, Social Slippages: Lin Huiyin's "In Ninety-Nine Degree Heat"

    Directory of Open Access Journals (Sweden)

    Carles Prado-Fonts

    2010-01-01

    Full Text Available The article reads Lin Huiyin’s short story “In Ninety-Nine Degree Heat” (1934 in relation to the context of 1930s China, as an innovative literary work which combines elements from both the Chinese and the Western traditions, and as a text which informs readers not only of the problematic of class and gender issues in 1930s Chinese society but also of the context of the liuxuesheng who returns to China –like Lin Huiyin herself. Focusing on questions like otherness, representation, and encounters, the essay analyzes how the episodic narrative structure of Lin’s short story echoes social and representational discourses in post-May Fourth China, at the same time that it explores issues such as social inequality, otherness and alienation, which were crucial to the liuxuesheng, and which reflect Lin’s own experience as a returned and alienated liuxuesheng at the time.

  16. GENII-LIN: a Multipurpose Health Physics Code Built on GENII-1.485

    Directory of Open Access Journals (Sweden)

    Marco Sumini

    2006-10-01

    Full Text Available The aim of the GENII-LIN project was to develop an open source multipurpose health physics code running on Linux platform, for calculating radiation dose and risk from radionuclides released to the environment. The general features of the GENII-LIN system include [1] capabilities for calculating radiation dose both for acute and chronic releases, with options for annual dose, committed dose and accumulated dose [2] capabilities for evaluating exposure pathways including direct exposure via water (swimming, boating, fishing, soil (buried and surface sources and air (semi-infinite cloud and finite cloud model, inhalation pathways and ingestion pathways. The release scenarios considered are: - acute release to air, from ground level or elevated sources, or to water; - chronic release to air, from ground level or elevated sources, or to water; - initial contamination of soil or surfaces. Keywords: radiation protection, Linux, health physics, risk analysis.

  17. An Adaptation of the Kernighan-Lin Heuristic to the Simple Graph Partitioning Problem

    DEFF Research Database (Denmark)

    Sørensen, Michael Malmros

    1999-01-01

    to this problem of the Kernighan-Lin exchange heuristic, which was originally developed for the closely related 2-partition problem. The evaluation is carried out on problem instances on graphs with up to 50 nodes for which the optimal partition values are known or upper bounds are available. The computational...... results show that among all instances with known optimal values the best partition values found by a randomized version of this heuristic lie well within 1% off the optimum....

  18. Primordial dwarfism gene maintains Lin28 expression to safeguard embryonic stem cells from premature differentiation.

    Science.gov (United States)

    Dai, Qian; Luan, Guangxin; Deng, Li; Lei, Tingjun; Kang, Han; Song, Xu; Zhang, Yujun; Xiao, Zhi-Xiong; Li, Qintong

    2014-05-08

    Primordial dwarfism (PD) is characterized by global growth failure, both during embryogenesis and postnatally. Loss-of-function germline mutations in La ribonucleoprotein domain family, member 7 (LAPR7) have recently been linked to PD. Paradoxically, LARP7 deficiency was previously assumed to be associated with increased cell growth and proliferation via activation of positive transcription elongation factor b (P-TEFb). Here, we show that Larp7 deficiency likely does not significantly increase P-TEFb activity. We further discover that Larp7 knockdown does not affect pluripotency but instead primes embryonic stem cells (ESCs) for differentiation via downregulation of Lin28, a positive regulator of organismal growth. Mechanistically, we show that Larp7 interacts with a poly(A) polymerase Star-PAP to maintain Lin28 mRNA stability. We propose that proper regulation of Lin28 and PTEFb is essential for embryonic cells to achieve a sufficient number of cell divisions prior to differentiation and ultimately to maintain proper organismal size. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  19. Dynamiques complexes et morphogenèse Introduction aux sciences non linéaires

    CERN Document Server

    Misbah, Chaouqi

    2011-01-01

    Les sciences non linéaires ont pour objet l’ensemble des phénomènes dont l’analyse résiste au principe de superposition. Elles concernent en grande partie les systèmes dits « complexes » dont l’interaction et l’interdépendance entre les parties empêchent de prédire précisément l’évolution du système. Pour expliquer ces phénomènes, deux approches complémentaires ont été proposées : la théorie des bifurcations et la théorie des catastrophes. Mais la pleine compréhension et la modélisation de la non-linéarité restent chacune un défi pour les scientifiques du XXIe siècle. C’est dans la perspective d’accompagner tous ceux qui voudront le relever que ce livre a été conçu. Son objectif est d’exposer au lecteur le langage et le formalisme nécessaires à l’étude de la non-linéarité. Partant d’exemples simples, pour ensuite atteindre un niveau d’abstraction visant l’universalité, l’auteur explore les divers scénarios possibles de bifurcations et les catastr...

  20. Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences.

    Science.gov (United States)

    Grandien, K; Sommer, R J

    2001-08-15

    Hox transcription factors have been implicated in playing a central role in the evolution of animal morphology. Many studies indicate the evolutionary importance of regulatory changes in Hox genes, but little is known about the role of functional changes in Hox proteins. In the nematodes Pristionchus pacificus and Caenorhabditis elegans, developmental processes can be compared at the cellular, genetic, and molecular levels and differences in gene function can be identified. The Hox gene lin-39 is involved in the regulation of nematode vulva development. Comparison of known lin-39 mutations in P. pacificus and C. elegans revealed both conservation and changes of gene function. Here, we study evolutionary changes of lin-39 function using hybrid transgenes and site-directed mutagenesis in an in vivo assay using C. elegans lin-39 mutants. Our data show that despite the functional differences of LIN-39 between the two species, Ppa-LIN-39, when driven by Cel-lin-39 regulatory elements, can functionally replace Cel-lin-39. Furthermore, we show that the MAPK docking and phosphorylation motifs unique for Cel-LIN-39 are dispensable for Cel-lin-39 function. Therefore, the evolution of lin-39 function is driven by changes in regulatory elements rather than changes in the protein itself.

  1. Response to Niklasson's comment on Lin, et al. (2012) : "the relation between postural movement and bilateral motor integration".

    Science.gov (United States)

    Lin, Chin-Kai; Kuo, Bor-Chen; Wu, Huey-Min

    2014-10-01

    In the study of Lin, Wu, Lin, Wu, Wu, Kuo, and Yeung (2012 ), the relationship between the validity of postural movement and bilateral motor integration in terms of sensory integration theory was examined. Postural movement is the ability to use the antigravity postures required for stabilization of the neck, trunk and upper extremities via muscle co-contractions in the neck and upper extremities, and balance. Niklasson's (2013 ) comment argued that postural movement should include primitive reflexes in terms of the general abilities approach. Niklasson (2013 ) focused on the efficacy of the treatment rather than the theoretical frameworks implied in the therapeutic activities. For that purpose Lin, et al. (2012 ) used sensory integration as the theoretical foundation, and the relationship between postural movement and bilateral motor integration was assessed via empirical data. The result of Lin, et al. (2012 ) was offered as a theoretical reference for therapeutic activities.

  2. On the reduction of generalized polylogarithms to Li_n and Li_2_,_2 and on the evaluation thereof

    International Nuclear Information System (INIS)

    Frellesvig, Hjalte; Tommasini, Damiano; Wever, Christopher

    2016-01-01

    We give expressions for all generalized polylogarithms up to weight four in terms of the functions log, Li_n, and Li_2_,_2, valid for arbitrary complex variables. Furthermore we provide algorithms for manipulation and numerical evaluation of Li_n and Li_2_,_2, and add codes in Mathematica and C++ implementing the results. With these results we calculate a number of previously unknown integrals, which we add in appendix C.

  3. LIN Dataset

    Data.gov (United States)

    Department of Homeland Security — This data is captured and helps to coordinate technical and scientific testing in the area of Trade Enforcement, WMD, Intellectual Property Rights, and Narcotics...

  4. LIN7A depletion disrupts cerebral cortex development, contributing to intellectual disability in 12q21-deletion syndrome.

    Directory of Open Access Journals (Sweden)

    Ayumi Matsumoto

    Full Text Available Interstitial deletion of 12q21 has been reported in four cases, which share several common clinical features, including intellectual disability (ID, low-set ears, and minor cardiac abnormalities. Comparative genomic hybridization (CGH analysis using the Agilent Human Genome CGH 180K array was performed with the genomic DNA from a two-year-old Japanese boy with these symptoms, as well as hypoplasia of the corpus callosum. Consequently, a 14 Mb deletion at 12q21.2-q21.33 (nt. 77 203 574-91 264 613 bp, which includes 72 genes, was detected. Of these, we focused on LIN7A, which encodes a scaffold protein that is important for synaptic function, as a possible responsible gene for ID, and we analyzed its role in cerebral cortex development. Western blotting analyses revealed that Lin-7A is expressed on embryonic day (E 13.5, and gradually increases in the mouse brain during the embryonic stage. Biochemical fractionation resulted in the enrichment of Lin-7A in the presynaptic fraction. Suppression of Lin-7A expression by RNAi, using in utero electroporation on E14.5, delayed neuronal migration on postnatal day (P 2, and Lin-7A-deficient neurons remained in the lower zone of the cortical plate and the intermediate zone. In addition, when Lin-7A was silenced in cortical neurons in one hemisphere, axonal growth in the contralateral hemisphere was delayed; development of these neurons was disrupted such that one half did not extend into the contralateral hemisphere after leaving the corpus callosum. Taken together, LIN7A is a candidate gene responsible for 12q21-deletion syndrome, and abnormal neuronal migration and interhemispheric axon development may contribute to ID and corpus callosum hypoplasia, respectively.

  5. LIN28B polymorphisms are associated with central precocious puberty and early puberty in girls

    Directory of Open Access Journals (Sweden)

    Sung Won Park

    2012-10-01

    Full Text Available &lt;B&gt;Purpose:&lt;/B&gt; Single-nucleotide polymorphism (SNP markers within &lt;i&gt;LIN28B&lt;/i&gt; have been reported to be related to the timing of pubertal growth. However, no study has investigated the frequency of genetic markers in girls with precocious puberty (PP or early puberty (EP. This study aimed to determine the frequency of putative genetic markers in girls with PP or EP. &lt;B&gt;Methods:&lt;/B&gt; Genomic DNAs were obtained from 77 and 109 girls that fulfilled the criteria for PP and EP, respectively. The controls in this study were 144 healthy volunteers between 20 and 30 years of age. The haplotypes were reconstructed using 11 SNPs of &lt;i&gt;LIN28B&lt;/i&gt;, and haplotype association analysis was performed. The haplotype frequencies were compared. Differences in the clinical and laboratory parameters were analyzed according to the haplotype dosage. &lt;B&gt;Results:&lt;/B&gt; Eleven SNPs in &lt;i&gt;LIN28B&lt;/i&gt; were all located in a block that was in linkage disequilibrium. The haplotype could be reconstructed using 2 representative SNPs, rs4946651 and rs369065. The AC haplotype was less frequently observed in the PP group than in the controls (0.069 vs. 0.144, &lt;I&gt;P&lt;/I&gt;=0.010. The trend that girls with non-AC haplotypes tended to have earlier puberty onset (&lt;I&gt;P&lt;/I&gt;=0.037 was illustrated even in the EP+PP patient group by Kaplan-Meier analysis. &lt;B&gt;Conclusion:&lt;/B&gt; The results of the present study showed that non-AC haplotypes of &lt;i&gt;LIN28B&lt;/i&gt;had a significant association with PP in girls.

  6. Lin28a Is Dormant, Functional, and Dispensable During Mouse Oocyte-to-Embryo Transition

    Czech Academy of Sciences Publication Activity Database

    Flemr, Matyáš; Moravec, Martin; Libová, Veronika; Sedláček, Radislav; Svoboda, Petr

    2014-01-01

    Roč. 90, č. 6 (2014), s. 1-9 ISSN 0006-3363 R&D Projects: GA MŠk LH13084; GA MŠk(CZ) LM2011032; GA ČR(CZ) GBP305/12/G034 Institutional support: RVO:68378050 Keywords : early development * genome activation * guinea pigs * Let-7 * LIN28 * mice * microRNA * oocyte * rats * RNAi * rodents * transgenic/ knockout model * voles * zygote Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 3.318, year: 2014

  7. Lin28a uses distinct mechanisms of binding to RNA and affects miRNA levels positively and negatively.

    Science.gov (United States)

    Nowak, Jakub Stanislaw; Hobor, Fruzsina; Downie Ruiz Velasco, Angela; Choudhury, Nila Roy; Heikel, Gregory; Kerr, Alastair; Ramos, Andres; Michlewski, Gracjan

    2017-03-01

    Lin28a inhibits the biogenesis of let-7 miRNAs by triggering the polyuridylation and degradation of their precursors by terminal uridylyltransferases TUT4/7 and 3'-5' exoribonuclease Dis3l2, respectively. Previously, we showed that Lin28a also controls the production of neuro-specific miRNA-9 via a polyuridylation-independent mechanism. Here we reveal that the sequences and structural characteristics of pre-let-7 and pre-miRNA-9 are eliciting two distinct modes of binding to Lin28a. We present evidence that Dis3l2 controls miRNA-9 production. Finally, we show that the constitutive expression of untagged Lin28a during neuronal differentiation in vitro positively and negatively affects numerous other miRNAs. Our findings shed light on the role of Lin28a in differentiating cells and on the ways in which one RNA-binding protein can perform multiple roles in the regulation of RNA processing. © 2017 Nowak et al.; Published by Cold Spring Harbor Laboratory Press for the RNA Society.

  8. Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

    International Nuclear Information System (INIS)

    Sokolova, O.S.; Shaburova, O.V.; Pechnikova, E.V.; Shaytan, A.K.; Krylov, S.V.; Kiselev, N.A.; Krylov, V.N.

    2014-01-01

    A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body

  9. Genome packaging in EL and Lin68, two giant phiKZ-like bacteriophages of P. aeruginosa

    Energy Technology Data Exchange (ETDEWEB)

    Sokolova, O.S., E-mail: sokolova@mail.bio.msu.ru [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaburova, O.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Pechnikova, E.V. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Shaytan, A.K. [M.V. Lomonosov Moscow State University, Moscow (Russian Federation); Krylov, S.V. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation); Kiselev, N.A. [A.V. Shoubnikov Institute of Crystallography RAS, Moscow (Russian Federation); Krylov, V.N. [I.I. Mechnikov Research Institute of Vaccines and Sera, RAMS, Moscow (Russian Federation)

    2014-11-15

    A unique feature of the Pseudomonas aeruginosa giant phage phiKZ is its way of genome packaging onto a spool-like protein structure, the inner body. Until recently, no similar structures have been detected in other phages. We have studied DNA packaging in P. aeruginosa phages EL and Lin68 using cryo-electron microscopy and revealed the presence of inner bodies. The shape and positioning of the inner body and the density of the DNA packaging in EL are different from those found in phiKZ and Lin68. This internal organization explains how the shorter EL genome is packed into a large EL capsid, which has the same external dimensions as the capsids of phiKZ and Lin68. The similarity in the structural organization in EL and other phiKZ-like phages indicates that EL is phylogenetically related to other phiKZ-like phages, and, despite the lack of detectable DNA homology, EL, phiKZ, and Lin68 descend from a common ancestor. - Highlights: • We performed a comparative structural study of giant P. aeruginosa phages: EL, Lin68 and phiKZ. • We revealed that the inner body is a common feature in giant phages. • The phage genome size correlates with the overall dimensions of the inner body.

  10. LEDWIRE: A Versatile Networking Platform for Smart LED Lighting Applications Using LIN-Bus and WSNs

    Directory of Open Access Journals (Sweden)

    Dimitrios D. Piromalis

    2016-05-01

    Full Text Available In this paper, the architecture of a versatile networking and control platform for Light-Emitting Diode (LED lighting applications is presented, based on embedded wireless and wired networking technologies. All the possible power and control signals distribution topologies of the lighting fixtures are examined with particular focus on dynamic lighting applications with design metrics as the cost, the required wiring installation expenses and maintenance complexity. The proposed platform is optimized for applications where the grouping of LED-based lighting fictures clusters is essential, as well as their synchronization. With such an approach, the distributed control and synchronization of LED lighting fixtures' clusters is performed through a versatile network that uses the single wire Local Interconnect Network (LIN bus. The proposed networking platform is presented in terms of its physical layer architecture, its data protocol configuration, and its functionality for smart control. As a proof of concept, the design of a LED lighting fixture together with a LIN-to-IEEE802.15.4/ZigBee data gateway is presented.

  11. Topografia ficcional: a construção do espaço nos manuscritos de Osman Lins

    Directory of Open Access Journals (Sweden)

    Francisco José Gonçalves Lima Rocha

    2013-01-01

    Full Text Available In the construction of the narrative space of his final, unfinished novel, A cabeça levada em triunfo, Osman Lins operates both verbal, with notes planning, as iconically, through drawings. Will try to show that the author’s purpose is to clarify the topography of the work, because it establishes and harmonizes the technical functions - ie, like space, says Osman Lins, “frame” the character – and symbolic means, ie. how the space reflects, like all other elements of the work, the questioning of the head-body dichotomy.

  12. Cultura da celebridade, fãs e a nova mídia: um estudo sobre a promoção da imagem e trabalho de Justin Bieber

    OpenAIRE

    Camyla da Silva Oliveira; Renata Prado Alves Silva

    2016-01-01

    Este artigo se propõe a analisar as dinâmicas de comunicação entre Justin Bieber e seus seguidores na web, buscando compreender as formas de promoção da imagem e trabalhos do artista nas novas mídias. Nos métodos de pesquisa se destacam a netnografia das redes de fãs e análise de conteúdo para as mensagens dos canais de comunicação oficiais, além das trocas de informação entre membros do fandom. Os resultados apontam para as novas mídias como plataforma dinâmica para divulgação de informações...

  13. Traitement statistique des distorsions non-linéaires pour la restauration des enregistrements sonores.

    OpenAIRE

    Picard , Guillaume

    2006-01-01

    L'objet de la thèse est l'étude, la modélisation et le traitement des distorsions non linéaires sonores, pour lesquelles les techniques actuelles s'avèrent impuissantes. L'approche retenue consiste à représenter, globalement, à la fois le signal audio à restaurer et le processus de distorsion, dans le cadre d'un modèle statistique. Cette approche présente un bon compromis entre une souhaitable généricité -possibilité de traiter à l'aide d'une méthode globale plusieurs types de distorsions- et...

  14. Reduction of EMC Emissions in Mixed Signal Integrated Circuits with Embedded LIN Driver

    Directory of Open Access Journals (Sweden)

    P. Hartl

    2016-06-01

    Full Text Available This paper describes several methods for reduction of electromagnetic emissions (EME of mixed signal integrated circuits (IC. The focus is on the impact that a LIN bus communication block has on a complex IC which contains analog blocks, noisy digital block, micro-core (µC and several types of memories. It is used in an automotive environment, where EMC emission reduction is one of the key success factors. Several proposed methods for EME reduction are described and implemented on three test chips. These methods include current consumption reduction, internal on-chip decoupling, ground separation and different linear voltage regulator topologies. Measurement results of several fabricated test chips are shown and discussed.

  15. QUANTUM INSPIRED PARTICLE SWARM COMBINED WITH LIN-KERNIGHAN-HELSGAUN METHOD TO THE TRAVELING SALESMAN PROBLEM

    Directory of Open Access Journals (Sweden)

    Bruno Avila Leal de Meirelles Herrera

    2015-12-01

    Full Text Available ABSTRACT The Traveling Salesman Problem (TSP is one of the most well-known and studied problems of Operations Research field, more specifically, in the Combinatorial Optimization field. As the TSP is a NP (Non-Deterministic Polynomial time-hard problem, there are several heuristic methods which have been proposed for the past decades in the attempt to solve it the best possible way. The aim of this work is to introduce and to evaluate the performance of some approaches for achieving optimal solution considering some symmetrical and asymmetrical TSP instances, which were taken from the Traveling Salesman Problem Library (TSPLIB. The analyzed approaches were divided into three methods: (i Lin-Kernighan-Helsgaun (LKH algorithm; (ii LKH with initial tour based on uniform distribution; and (iii an hybrid proposal combining Particle Swarm Optimization (PSO with quantum inspired behavior and LKH for local search procedure. The tested algorithms presented promising results in terms of computational cost and solution quality.

  16. José Lins do Rego: um guia brasileiro de Israel

    Directory of Open Access Journals (Sweden)

    Glauber Pereira Quintão

    2010-03-01

    Full Text Available Este artigo procura analisar, de forma crítica, o livro de José Lins do Rego, Roteiro de Israel, 1955. Busca-­se destacar duas facetas suplementares: a de um olhar poético e a de uma preocupação ético-política lançados pelo escritor sobre a construção do novo Estado de Israel. Observa-­se também uma relação entre os signos da modernidade e das histórias arcaica judaicas. Para isso, usa-­se o conceito de palimpsesto, de Gerard Genette, e de flâneur, de Walter Benjamim.

  17. Lin28B promotes Müller glial cell de-differentiation and proliferation in the regenerative rat retinas

    Science.gov (United States)

    Tao, Zui; Zhao, Chen; Jian, Qian; Gillies, Mark; Xu, Haiwei; Yin, Zheng Qin

    2016-01-01

    Retinal regeneration and repair are severely impeded in higher mammalian animals. Although Müller cells can be activated and show some characteristics of progenitor cells when injured or under pathological conditions, they quickly form gliosis scars. Unfortunately, the basic mechanisms that impede retinal regeneration remain unknown. We studied retinas from Royal College of Surgeon (RCS) rats and found that let-7 family molecules, let-7e and let-7i, were significantly overexpressed in Müller cells of degenerative retinas. It demonstrated that down-regulation of the RNA binding protein Lin28B was one of the key factors leading to the overexpression of let-7e and let-7i. Lin28B ectopic expression in the Müller cells suppressed overexpression of let-7e and let-7i, stimulated and mobilized Müller glia de-differentiation, proliferation, promoted neuronal commitment, and inhibited glial fate acquisition of de-differentiated Müller cells. ERG recordings revealed that the amplitudes of a-wave and b-wave were improved significantly after Lin28B was delivered into the subretinal space of RCS rats. In summary, down-regulation of Lin28B as well as up-regulation of let-7e and let-7i may be the main factors that impede Müller cell de-differentiation and proliferation in the retina of RCS rats. PMID:27384999

  18. [Analysis of acid rain characteristics of Lin'an Regional Background Station using long-term observation data].

    Science.gov (United States)

    Li, Zheng-Quan; Ma, Hao; Mao, Yu-Ding; Feng, Tao

    2014-02-01

    Using long-term observation data of acid rain at Lin'an Regional Background Station (Lin'an RBS), this paper studied the interannual and monthly variations of acid rain, the reasons for the variations, and the relationships between acid rain and meteorological factors. The results showed that interannual variation of acid rain at Lin'an RBS had a general increasing trend in which there were two obvious intensifying processes and two distinct weakening processes, during the period ranging from 1985 to 2012. In last two decades, the monthly variation of acid rain at Lin'an RBS indicated that rain acidity and frequency of severe acid rain were increasing but the frequency of weak acid rain was decreasing when moving towards bilateral side months of July. Acid rain occurrence was affected by rainfall intensity, wind speed and wind direction. High frequency of severe acid rain and low frequency of weak acid rain were on days with drizzle, but high frequency of weak acid rain and low frequency of severe acid rain occurred on rainstorm days. With wind speed upgrading, the frequency of acid rain and the proportion of severe acid rain were declining, the pH value of precipitation was reducing too. Another character is that daily dominant wind direction of weak acid rain majorly converged in S-W section ,however that of severe acid rain was more likely distributed in N-E section. The monthly variation of acid rain at Lin'an RBS was mainly attributed to precipitation variation, the increasing and decreasing of monthly incoming wind from SSE-WSW and NWN-ENE sections of wind direction. The interannual variation of acid rain could be due to the effects of energy consumption raising and significant green policies conducted in Zhejiang, Jiangsu and Shanghai.

  19. LIN28 expression in malignant germ cell tumors down-regulates let-7 and increases oncogene levels

    Science.gov (United States)

    Murray, Matthew J.; Saini, Harpreet K.; Siegler, Charlotte A.; Hanning, Jennifer E.; Barker, Emily M.; van Dongen, Stijn; Ward, Dawn M.; Raby, Katie L.; Groves, Ian J.; Scarpini, Cinzia G.; Pett, Mark R.; Thornton, Claire M.; Enright, Anton J.; Nicholson, James C.; Coleman, Nicholas

    2013-01-01

    Despite their clinico-pathologic heterogeneity, malignant germ-cell-tumors (GCTs) share molecular abnormalities that are likely to be functionally important. In this study, we investigated the potential significance of down-regulation of the let-7 family of tumor-suppressor microRNAs in malignant-GCTs. Microarray results from pediatric and adult samples (n=45) showed that LIN28, the negative-regulator of let-7 biogenesis, was abundant in malignant-GCTs, regardless of patient age, tumor site or histologic subtype. Indeed, a strong negative-correlation existed between LIN28 and let-7 levels in specimens with matched datasets. Low let-7 levels were biologically significant, since the sequence complementary to the 2-7nt common let-7 seed ‘GAGGUA’ was enriched in the 3′untranslated regions of mRNAs up-regulated in pediatric and adult malignant-GCTs, compared with normal gonads (a mixture of germ cells and somatic cells). We identified 27 mRNA targets of let-7 that were up-regulated in malignant-GCT cells, confirming significant negative-correlations with let-7 levels. Among 16 mRNAs examined in a largely independent set of specimens by qRT-PCR, we defined negative-associations with let-7e levels for six oncogenes, including MYCN, AURKB, CCNF, RRM2, MKI67 and C12orf5 (when including normal control tissues). Importantly, LIN28 depletion in malignant-GCT cells restored let-7 levels and repressed all of these oncogenic let-7 mRNA targets, with LIN28 levels correlating with cell proliferation and MYCN levels. Conversely, ectopic expression of let-7e was sufficient to reduce proliferation and down-regulate MYCN, AURKB and LIN28, the latter via a double-negative feedback loop. We concluded that the LIN28/let-7 pathway has a critical pathobiological role in malignant-GCTs and therefore offers a promising target for therapeutic intervention. PMID:23774216

  20. Analysis of a lin-42/period Null Allele Implicates All Three Isoforms in Regulation of Caenorhabditis elegans Molting and Developmental Timing

    Directory of Open Access Journals (Sweden)

    Theresa L. B. Edelman

    2016-12-01

    Full Text Available The Caenorhabditis elegans heterochronic gene pathway regulates the relative timing of events during postembryonic development. lin-42, the worm homolog of the circadian clock gene, period, is a critical element of this pathway. lin-42 function has been defined by a set of hypomorphic alleles that cause precocious phenotypes, in which later developmental events, such as the terminal differentiation of hypodermal cells, occur too early. A subset of alleles also reveals a significant role for lin-42 in molting; larval stages are lengthened and ecdysis often fails in these mutant animals. lin-42 is a complex locus, encoding overlapping and nonoverlapping isoforms. Although existing alleles that affect subsets of isoforms have illuminated important and distinct roles for this gene in developmental timing, molting, and the decision to enter the alternative dauer state, it is essential to have a null allele to understand all of the roles of lin-42 and its individual isoforms. To remedy this problem and discover the null phenotype, we engineered an allele that deletes the entire lin-42 protein-coding region. lin-42 null mutants are homozygously viable, but have more severe phenotypes than observed in previously characterized hypomorphic alleles. We also provide additional evidence for this conclusion by using the null allele as a base for reintroducing different isoforms, showing that each isoform can provide heterochronic and molting pathway activities. Transcript levels of the nonoverlapping isoforms appear to be under coordinate temporal regulation, despite being driven by independent promoters. The lin-42 null allele will continue to be an important tool for dissecting the functions of lin-42 in molting and developmental timing.

  1. Overexpression of Lin28b in Neural Stem Cells is Insufficient for Brain Tumor Formation, but Induces Pathological Lobulation of the Developing Cerebellum.

    Science.gov (United States)

    Wefers, Annika K; Lindner, Sven; Schulte, Johannes H; Schüller, Ulrich

    2017-02-01

    LIN28B is a homologue of the RNA-binding protein LIN28A and regulates gene expression during development and carcinogenesis. It is strongly upregulated in a variety of brain tumors, such as medulloblastoma, embryonal tumor with multilayered rosettes (ETMR), atypical teratoid/rhabdoid tumor (AT/RT), or glioblastoma, but the effect of an in vivo overexpression of LIN28B on the developing central nervous system is unknown. We generated transgenic mice that either overexpressed Lin28b in Math1-positive cerebellar granule neuron precursors or in a broad range of Nestin-positive neural precursors. Sections of the cerebellar vermis from adult Math1-Cre::lsl-Lin28b mice had an additional subfissure in lobule IV. Vermes from p0 and p7 Nestin-Cre::lsl-Lin28b mice appeared normal, but we found a pronounced vermal hypersublobulation at p15 and p21 in these mice. Also, the external granule cell layer (EGL) was thicker at p15 than in controls, contained more proliferating cells, and persisted up to p21. Consistently, some Pax6- and NeuN-positive cells were present in the EGL of Nestin-Cre::lsl-Lin28b mice even at p21, and we detected more NeuN-positive granule neuron precursors in the molecular layer (ML) as compared to control. Finally, we found some residual Pax2-positive precursors of inhibitory interneurons in the ML of Nestin-Cre::lsl-Lin28b mice at p21, which have already disappeared in controls. We conclude that while overexpression of LIN28B in Nestin-positive cells does not lead to tumor formation, it results in a protracted development of granule cells and inhibitory interneurons and leads to a hypersublobulation of the cerebellar vermis.

  2. In vitro and in vivo antimicrobial activities of seeds of Caesalpinia bonduc (Lin.) Roxb.

    Science.gov (United States)

    Arif, Tasleem; Mandal, T K; Kumar, Naresh; Bhosale, J D; Hole, Archana; Sharma, G L; Padhi, M M; Lavekar, G S; Dabur, Rajesh

    2009-05-04

    Caesalpinia bonduc (Lin.) Roxb. is a known drug in Ayurveda to treat various diseases specifically tumors, cysts and cystic fibrosis (CF). The aim of this study was to assess in vitro as well as in vivo antimicrobial activity of Caesalpinia bonduc seeds. The in vitro antimicrobial activities of seed coat and seed kernel extracts were investigated by microbroth dilution assay. In vivo activities of hydro-alcoholic extracts were investigated in rat models of chronic Pseudomonas aeruginosa pneumonia mimicking that in patients with cystic fibrosis. Various extracts of plant seeds exhibited in vitro antimicrobial activities in a range of 22-350 microg/ml. The extracts also showed activity against methicillin resistant (MR) Staphylococcus aureus and ampicillin resistant (AR) Pseudomonas aeruginosa as in the sensitive strains. In rat model of chronic Pseudomonas aeruginosa pneumonia, hydro-alcoholic extracts of Caesalpinia bonduc seed kernel (CBSK) and Caesalpinia bonduc seed coat (CBSC) were injected subcutaneously in the test groups of animals. The control groups were treated with cortisone and saline. Two weeks after challenge with Pseudomonas aeruginosa, the CBSK treated animals showed a significant bacterial clearance from the lungs (PCaesalpinia bonduc may have the potential to be promising natural medicine, with other forms of treatments, for CF patients with chronic Pseudomonas aeruginosa lung infections.

  3. Solving quantum optimal control problems using Clebsch variables and Lin constraints

    Science.gov (United States)

    Delgado-Téllez, M.; Ibort, A.; Rodríguez de la Peña, T.

    2018-01-01

    Clebsch variables (and Lin constraints) are applied to the study of a class of optimal control problems for affine-controlled quantum systems. The optimal control problem will be modelled with controls defined on an auxiliary space where the dynamical group of the system acts freely. The reciprocity between both theories: the classical theory defined by the objective functional and the quantum system, is established by using a suitable version of Lagrange’s multipliers theorem and a geometrical interpretation of the constraints of the system as defining a subspace of horizontal curves in an associated bundle. It is shown how the solutions of the variational problem defined by the objective functional determine solutions of the quantum problem. Then a new way of obtaining explicit solutions for a family of optimal control problems for affine-controlled quantum systems (finite or infinite dimensional) is obtained. One of its main advantages, is the the use of Clebsch variables allows to compute such solutions from solutions of invariant problems that can often be computed explicitly. This procedure can be presented as an algorithm that can be applied to a large class of systems. Finally, some simple examples, spin control, a simple quantum Hamiltonian with an ‘Elroy beanie’ type classical model and a controlled one-dimensional quantum harmonic oscillator, illustrating the main features of the theory, will be discussed.

  4. Long noncoding RNA TUG1 facilitates osteogenic differentiation of periodontal ligament stem cells via interacting with Lin28A.

    Science.gov (United States)

    He, Qin; Yang, Shuangyan; Gu, Xiuge; Li, Mengying; Wang, Chunling; Wei, Fulan

    2018-04-19

    Periodontal ligament stem cells (PDLSCs) are mesenchymal stem cells derived from dental tissues with multidirectional differentiation potential and excellent self-renewing ability. Recently, long noncoding RNAs (lncRNAs) have been shown to play important roles in MSC osteogenic differentiation. In this study, we found that taurine upregulated gene 1 (TUG1), an evolutionarily conserved and widely present lncRNA was significantly upregulated in osteogenically induced PDLSCs compared to their undifferentiated counterparts. Further investigation demonstrated that the expression of TUG1 was positively correlated with the osteogenic differentiation of PDLSCs following the induction, as evidenced by the increase in cellular alkaline phosphatase (ALP) level, formation of calcium nodules, and the upregulation of several osteogenic-related gene markers such as ALP, osteocalcin (OCN), and runt-related transcription factor 2 (Runx2). Conversely, TUG1 knockdown was demonstrated to inhibit the potential of PDLSCs for osteogenic differentiation. Using bioinformatics analysis, we identified lin-28 homolog A (Lin28A) as a potential target of TUG1 during osteogenic differentiation of PDLSCs. Lin28A was found to be significantly downregulated in TUG1-repressed PDLSCs and contained multiple binding sites for lncRNA TUG1. Moreover, suppression of Lin28A was shown to be able to inhibit osteogenic differentiation and decreased the expression of several osteogenic genes. Taken together, these results could help researchers better understand the mechanism that governs the osteogenic differentiation of PDLSCs, and also serve as a stepping stone for the development of novel therapeutic strategies that can be used to regenerate dental tissues.

  5. A role for the malignant brain tumour (MBT domain protein LIN-61 in DNA double-strand break repair by homologous recombination.

    Directory of Open Access Journals (Sweden)

    Nicholas M Johnson

    Full Text Available Malignant brain tumour (MBT domain proteins are transcriptional repressors that function within Polycomb complexes. Some MBT genes are tumour suppressors, but how they prevent tumourigenesis is unknown. The Caenorhabditis elegans MBT protein LIN-61 is a member of the synMuvB chromatin-remodelling proteins that control vulval development. Here we report a new role for LIN-61: it protects the genome by promoting homologous recombination (HR for the repair of DNA double-strand breaks (DSBs. lin-61 mutants manifest numerous problems associated with defective HR in germ and somatic cells but remain proficient in meiotic recombination. They are hypersensitive to ionizing radiation and interstrand crosslinks but not UV light. Using a novel reporter system that monitors repair of a defined DSB in C. elegans somatic cells, we show that LIN-61 contributes to HR. The involvement of this MBT protein in HR raises the possibility that MBT-deficient tumours may also have defective DSB repair.

  6. Cultura da celebridade, fãs e a nova mídia: um estudo sobre a promoção da imagem e trabalho de Justin Bieber

    Directory of Open Access Journals (Sweden)

    Camyla da Silva Oliveira

    2016-09-01

    Full Text Available Este artigo se propõe a analisar as dinâmicas de comunicação entre Justin Bieber e seus seguidores na web, buscando compreender as formas de promoção da imagem e trabalhos do artista nas novas mídias. Nos métodos de pesquisa se destacam a netnografia das redes de fãs e análise de conteúdo para as mensagens dos canais de comunicação oficiais, além das trocas de informação entre membros do fandom. Os resultados apontam para as novas mídias como plataforma dinâmica para divulgação de informações não apenas através de canais oficiais da celebridade, mas especialmente por meio do compartilhamento e apropriação de conteúdos de fãs para fãs, que utilizam a web para criação, publicação e disseminação de mensagens, alimentando a expectativa de se comunicarem diretamente com seu ídolo.

  7. DPL-1 DP, LIN-35 Rb and EFL-1 E2F act with the MCD-1 zinc-finger protein to promote programmed cell death in Caenorhabditis elegans.

    Science.gov (United States)

    Reddien, Peter W; Andersen, Erik C; Huang, Michael C; Horvitz, H Robert

    2007-04-01

    The genes egl-1, ced-9, ced-4, and ced-3 play major roles in programmed cell death in Caenorhabditis elegans. To identify genes that have more subtle activities, we sought mutations that confer strong cell-death defects in a genetically sensitized mutant background. Specifically, we screened for mutations that enhance the cell-death defects caused by a partial loss-of-function allele of the ced-3 caspase gene. We identified mutations in two genes not previously known to affect cell death, dpl-1 and mcd-1 (modifier of cell death). dpl-1 encodes the C. elegans homolog of DP, the human E2F-heterodimerization partner. By testing genes known to interact with dpl-1, we identified roles in cell death for four additional genes: efl-1 E2F, lin-35 Rb, lin-37 Mip40, and lin-52 dLin52. mcd-1 encodes a novel protein that contains one zinc finger and that is synthetically required with lin-35 Rb for animal viability. dpl-1 and mcd-1 act with efl-1 E2F and lin-35 Rb to promote programmed cell death and do so by regulating the killing process rather than by affecting the decision between survival and death. We propose that the DPL-1 DP, MCD-1 zinc finger, EFL-1 E2F, LIN-35 Rb, LIN-37 Mip40, and LIN-52 dLin52 proteins act together in transcriptional regulation to promote programmed cell death.

  8. Relevance of the Lin's and Host hydropedological models to predict grape yield and wine quality

    Directory of Open Access Journals (Sweden)

    E. A. C. Costantini

    2009-09-01

    Full Text Available The adoption of precision agriculture in viticulture could be greatly enhanced by the diffusion of straightforward and easy to be applied hydropedological models, able to predict the spatial variability of available soil water. The Lin's and Host hydropedological models were applied to standard soil series descriptions and hillslope position, to predict the distribution of hydrological functional units in two vineyard and their relevance for grape yield and wine quality. A three-years trial was carried out in Chianti (Central Italy on Sangiovese. The soils of the vineyards differentiated in structure, porosity and related hydropedological characteristics, as well as in salinity. Soil spatial variability was deeply affected by earth movement carried out before vine plantation. Six plots were selected in the different hydrological functional units of the two vineyards, that is, at summit, backslope and footslope morphological positions, to monitor soil hydrology, grape production and wine quality. Plot selection was based upon a cluster analysis of local slope, topographic wetness index (TWI, and cumulative moisture up to the root limiting layer, appreciated by means of a detailed combined geophysical survey. Water content, redox processes and temperature were monitored, as well as yield, phenological phases, and chemical analysis of grapes. The isotopic ratio δ13C was measured in the wine ethanol upon harvesting to evaluate the degree of stress suffered by vines. The grapes in each plot were collected for wine making in small barrels. The wines obtained were analysed and submitted to a blind organoleptic testing.

    The results demonstrated that the combined application of the two hydropedological models can be used for the prevision of the moisture status of soils cultivated with grape during summertime in Mediterranean climate. As correctly foreseen by the models, the amount of mean daily transpirable soil water (TSW during

  9. Optical and electrical properties of zinc oxide thin films with low resistivity via Li-N dual-acceptor doping

    Energy Technology Data Exchange (ETDEWEB)

    Zhang Daoli, E-mail: zhang_daoli@mail.hust.edu.cn [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Zhang Jianbing [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Guo Zhe [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Miao Xiangshui [Department of Electronic Science and Technology, Huazhong University of Science and Technology, No. 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China); Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Hongshan District, Wuhan City, Hubei Province 430074 (China)

    2011-05-19

    Highlights: > Zinc oxide films have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified SILAR method. > The resistivity of ZnO film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1}, carrier concentration of 8.02 x 1018 cm{sup -3}, and transmittance of about 80% in visible range showing good crystallinity with prior c-axis orientation. > A shallow acceptor level of 91 meV is identified from free-to-neutral-acceptor transitions. > Another deep level of 255 meV was ascribed to Li{sub Zn}-Li{sub i} complex. - Abstract: Zinc oxide thin films with low resistivity have been deposited on glass substrates by Li-N dual-acceptor doping method via a modified successive ionic layer adsorption and reaction process. The thin films were systematically characterized via scanning electron microscopy (SEM), atomic force microscopy (AFM), X-ray diffraction, ultraviolet-visible spectrophotometry and fluorescence spectrophotometry. The resistivity of zinc oxide film was found to be 1.04 {Omega} cm with a Hall mobility of 0.749 cm{sup 2} V{sup -1} s{sup -1} and carrier concentration of 8.02 x 10{sup 18} cm{sup -3}. The Li-N dual-acceptor doped zinc oxide films showed good crystallinity with prior c-axis orientation, and high transmittance of about 80% in visible range. Moreover, the effects of Li doping level and other parameters on crystallinity, electrical and ultraviolet emission of zinc oxide films were investigated.

  10. Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K., E-mail: mishima-k@dent.showa-u.ac.jp

    2013-05-01

    Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities.

  11. Lin28a is a putative factor in regulating cancer stem cell-like properties in side population cells of oral squamous cell carcinoma

    International Nuclear Information System (INIS)

    Hayashi, S.; Tanaka, J.; Okada, S.; Isobe, T.; Yamamoto, G.; Yasuhara, R.; Irie, T.; Akiyama, C.; Kohno, Y.; Tachikawa, T.; Mishima, K.

    2013-01-01

    Cancer stem cells (CSCs) are among the target cells of cancer therapy because they are uniquely involved in both cancer progression and sensitivity to chemotherapeutic agents. We identified side population (SP) cells, which are known to be an enriched population of CSC, in five oral squamous cell carcinoma (OSCC) cells (SCC9, SCC25, TOSCC7, TOSCC17, and TOSCC23). The percentages of SP cells ranged from 0% to 3.3%, with TOSCC23 cells showing the highest percentages of SP cells (3.3% of the total cell population). The SP cells isolated from TOSCC23 cells also showed greater cell proliferation and invasion compared to non-SP (MP) cells. Therefore, our initial findings suggested that SP cells were enriched for CSC-like cells. Furthermore, DNA microarray analysis revealed that the expression of cell proliferation-related and anti-apoptotic genes was greater in SP cells compared to MP cells. We focused on Lin28a, which showed the highest expression (approximately 22-fold) among the upregulated genes. The overexpression of Lin28a in TOSCC23 cells increased their proliferation, colony formation, and invasion. These findings suggest that Lin28a is an appropriate CSC target molecule for OSCC treatment - Highlights: ► Lin28a is a SP cell-specific factor in oral squamous cell carcinoma (OSCC) cells. ► SP cells in OSCC cells show cancer stem cell-like properties. ► Lin28a regulates OSCC proliferative and invasive activities

  12. Opposing Post-transcriptional Control of InR by FMRP and LIN-28 Adjusts Stem Cell-Based Tissue Growth

    Directory of Open Access Journals (Sweden)

    Arthur Luhur

    2017-12-01

    Full Text Available Summary: Although the intrinsic mechanisms that control whether stem cells divide symmetrically or asymmetrically underlie tissue growth and homeostasis, they remain poorly defined. We report that the RNA-binding protein fragile X mental retardation protein (FMRP limits the symmetric division, and resulting expansion, of the stem cell population during adaptive intestinal growth in Drosophila. The elevated insulin sensitivity that FMRP-deficient progenitor cells display contributes to their accelerated expansion, which is suppressed by the depletion of insulin-signaling components. This FMRP activity is mediated solely via a second conserved RNA-binding protein, LIN-28, known to boost insulin signaling in stem cells. Via LIN-28, FMRP controls progenitor cell behavior by post-transcriptionally repressing the level of insulin receptor (InR. This study identifies the stem cell-based mechanism by which FMRP controls tissue adaptation, and it raises the possibility that defective adaptive growth underlies the accelerated growth, gastrointestinal, and other symptoms that affect fragile X syndrome patients. : Luhur et al. report that FMRP acts via LIN-28 in progenitor cells to dampen the adaptive expansion of intestinal tissue in the fruit fly, raising the possibility that defective LIN28-mediated adaptive growth underlies some of the symptoms that affect fragile X syndrome patients. Keywords: FMRP, fmr1, LIN-28, insulin receptor, IIS, adaptive growth, tissue resizing, intestinal stem cell, insulin sensitivity

  13. Comparability of estimating energy rebound effect should be based on uniform mechanism and benchmark: A reply to Du and Lin

    International Nuclear Information System (INIS)

    Li, Chengyu; Shao, Shuai; Yang, Lili; Yu, Mingliang

    2016-01-01

    Du and Lin (2015) argued that the estimation model of the economy-wide energy rebound effect proposed by Shao et al. (2014) should be revised and provided an alternative approach, which they considered to be more consistent with the definition of the rebound effect. However, in this comment, we do not find a valid correction or modification to our original model, because their criticism logic does not originate from the corresponding mechanism in Shao et al. (2014), and their estimation formula has a different benchmark with ours. Moreover, their data samples were also different from ours, generating the incomparable results, and there are some irrational results in the comment. Even based on different estimation formulas in the two studies and using the same estimation method and data sample, the comparison results show that the problem of the estimation formula in our previous study which they claimed does not really exist. We argue that this comment is not consistent with the principle of the rebound effect. Actually, their work can be only regarded as proposing an alternative approach for the estimate of the rebound effect. Therefore, their argument is not enough to overturn our previous study. - Highlights: • A reply to Du and Lin (2015), who questioned our previous study, is provided. • Their criticism logic does not originate from our corresponding mechanism. • Their estimation formula has a different benchmark with ours. • Different data samples in the two papers make their results incomparable. • Their argument is not enough to overturn our previous study.

  14. Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B.

    Science.gov (United States)

    Lee, Chih-Yung Sean; Lu, Tu; Seydoux, Geraldine

    2017-11-07

    Nanos RNA-binding proteins are required for germline development in metazoans, but the underlying mechanisms remain poorly understood. We have profiled the transcriptome of primordial germ cells (PGCs) lacking the nanos homologs nos-1 and nos-2 in C. elegans. nos-1nos-2 PGCs fail to silence hundreds of transcripts normally expressed in oocytes. We find that this misregulation is due to both delayed turnover of maternal transcripts and inappropriate transcriptional activation. The latter appears to be an indirect consequence of delayed turnover of the maternally-inherited transcription factor LIN-15B, a synMuvB class transcription factor known to antagonize PRC2 activity. PRC2 is required for chromatin reprogramming in the germline, and the transcriptome of PGCs lacking PRC2 resembles that of nos-1nos-2 PGCs. Loss of maternal LIN-15B restores fertility to nos-1nos-2 mutants. These findings suggest that Nanos promotes germ cell fate by downregulating maternal RNAs and proteins that would otherwise interfere with PRC2-dependent reprogramming of PGC chromatin.

  15. Weak activity of haloalkane dehalogenase LinB with 1,2,3-trichloropropane revealed by X-Ray crystallography and microcalorimetry.

    Science.gov (United States)

    Monincová, Marta; Prokop, Zbynek; Vévodová, Jitka; Nagata, Yuji; Damborsky, Jirí

    2007-03-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (k(cat) = 0.005 s(-1)) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities.

  16. Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

    Science.gov (United States)

    Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

    2007-01-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of LinB with TCP using X-ray crystallography and microcalorimetry. This observation makes LinB a useful starting material for the development of a new biocatalyst toward TCP by protein engineering. Microcalorimetry is proposed to be a universal method for the detection of weak enzymatic activities. Detection of these activities is becoming increasingly important for engineering novel biocatalysts using the scaffolds of proteins with promiscuous activities. PMID:17259360

  17. [Heavy metal pollution characteristics and ecological risk analysis for soil in Phyllostachys praecox stands of Lin'an].

    Science.gov (United States)

    Fang, Xiao-bo; Shi, Han; Liao, Xin-feng; Lou, Zhong; Zhou, Lyu-yan; Yu, Hai-xia; Yao, Lin; Sun, Li-ping

    2015-06-01

    An investigation was carried out in an attempt to reveal the characteristics of heavy metals contamination in the soils of Phyllostachys praecox forest in Lin' an. Based on the concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in 160 topsoil samples, the pollution status and ecological risks of heavy metals in the soils were assessed by single factor pollution index, Nemerow integrated pollution index and Hankanson potential ecological risk index. The spatial variability of heavy metal concentrations in the soils closely related to the distribution of traffic, industrial and livestock pollution sources. The average concentrations of Hg, As, Cu, Pb, Zn, Cd, Cr, Ni, Co and Mn in the soils were 0.16, 7.41, 34.36, 87.98, 103.98, 0.26, 59.12, 29.56, 11.44 and 350.26 mg · kg(-1), respectively. Pb, Cd, Zn and Cu concentrations were as 2.89, 1.70, 1.12 and 1.12 times as the background values of soil in Zhejiang Province, respectively. But their concentrations were all lower than the threshold values of the National Environmental Quality Standard for Soil (GB 15618-1995). The average single factor pollution index revealed that the level of heavy metal pollution in the soils was in order of Pb>Cd>Cu= Zn>Hg>As>Ni>Co>Cr>Mn. Pb pollution was of moderate level while Cd, Cu and Zn pollutions were slight. There was no soil pollution caused by the other heavy metals. However, the Nemerow integrated pollution index showed that all the 160 soil samples were contaminated by heavy metals to a certain extent. Among total 160 soil samples, slight pollution level, moderate pollution level and heavy pollution level accounted for 55.6%, 29.4% and 15.0%, respectively. The average single factor potential ecological risk index (Er(i)) implied that the potential ecological risk related to Cd reached moderate level, while the others were of slight level. Furthermore, Cd and Hg showed higher potential ecological risk indices which reached up to 256.82 and 187.33 respectively

  18. A MULHER NEGRA E AS RELAÇÕES DE GÊNERO EM MENINO DE ENGENHO DE JOSÉ LINS DO REGO THE BLACK WOMAN AND GENDER RELATIONS IN MENINO DE ENGENHO BY JOSÉ LINS DO REGO

    Directory of Open Access Journals (Sweden)

    Zélia Monteiro Bora ; Marina Rodrigues de Oliveira

    2011-02-01

    Full Text Available Os romances do ciclo da cana-de-açúcar, do escritor paraibano José Lins do Rego (1901-1957 e a sua relação com a sociedade e a cultura destacam-se enquanto abordagens ficcionais, através das quais o escritor buscou representar aspectos relevantes para o entendimento das relações de gênero no Nordeste, no começo do século vinte. Tal representação, indiscutivelmente, reflete a perspectiva de um narrador profundamente marcado pelo lugar privilegiado de onde narra e de sua condição existencial, como o neto de um senhor de engenho. Diante desses aspectos, propomo- nos a analisar brevemente as implicações dessa perspectiva sobre a construção simbólica da personagem negra representada no romance. Para tanto, serão utilizados como referenciais críticos, além do citado romance, os estudos de Zagury (1982, Albuquerque Jr. (1999, Azevedo (1996, 2007, Freyre (2006 Chaguri (2009, Schwarz (2008 e Raboni (2010.The so called sugar cane cycle novels by the Parahyban writer Jose Lins do Rego (1901-197 and its relationship with society and culture constitute themselves as fictional approaches through which the writer sought to represent aspects to the understanding of gender relations in the Northeast of Brazil in the early twentieth century. Such representation, undoubtedly reflects the perspective of a narrator deeply marked by the privileged place from which he narrates and his existential condition, as the son of a plantation owner. Given these aspects, we propose to examine briefly the implications of his perspective on the symbolic construction of the black woman characteres represented in the novel. The following

  19. Search for the signature of a halo structure in the p(6He,6Li)n reaction

    International Nuclear Information System (INIS)

    Cortina-Gil, M.D.; Roussel-Chomaz, P.; Mittig, W.; Casandjian, J.M.; Chartier, M.; Alamanos, N.; Auger, F.; Fekou-Youmbi, V.; Blumenfeld, Y.; and others.

    1995-01-01

    The elastic scattering p( 6 He, 6 He)p and charge exchange reaction p( 6 He, 6 Li)n have been measured in reverse kinematics with a secondary 6 He beam. The angular distributions for these reactions were obtained. In the case of the charge exchange reaction, the ratio of the cross section for the Gamow-Teller transition to the ground state, and for the Fermi transition to the isobaric analog state is a measure of the relative strength of the two components of the exchange interaction. This ratio is found compatible with existing systematics for stable T=1 nuclei, and no clear signature of a halo structure was found in the present data. (author)

  20. Regio- and Enantioselective Sequential Dehalogenation of rac-1,3-Dibromobutane by Haloalkane Dehalogenase LinB.

    Science.gov (United States)

    Gross, Johannes; Prokop, Zbyněk; Janssen, Dick; Faber, Kurt; Hall, Mélanie

    2016-08-03

    The hydrolytic dehalogenation of rac-1,3-dibromobutane catalyzed by the haloalkane dehalogenase LinB from Sphingobium japonicum UT26 proceeds in a sequential fashion: initial formation of intermediate haloalcohols followed by a second hydrolytic step to produce the final diol. Detailed investigation of the course of the reaction revealed favored nucleophilic displacement of the sec-halogen in the first hydrolytic event with pronounced R enantioselectivity. The second hydrolysis step proceeded with a regioselectivity switch at the primary position, with preference for the S enantiomer. Because of complex competition between all eight possible reactions, intermediate haloalcohols formed with moderate to good ee ((S)-4-bromobutan-2-ol: up to 87 %). Similarly, (S)-butane-1,3-diol was formed at a maximum ee of 35 % before full hydrolysis furnished the racemic diol product. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

  1. Digital cultural heritage and its applications: case studies of Digital Mogao Grottos and Chi Lin Nunnery reconstruction

    Science.gov (United States)

    Li, Deren; Du, Zhiqiang; Zhu, Yixuan; Wang, Tingsong

    2010-11-01

    Considerable damage has been done to the cultural heritage sites around the world ranging from natural erosion to artificial destruction. With the development of information sciences, frontier technologies are actively introduced to help protect cultural heritage sites. The new concept of a Digital Cultural Heritage has been presented for culture protection and is gradually becoming an efficient method to solve or to remit various difficult problems. This paper puts forward a digitalization method for cultural heritage sites which rationally integrates and utilizes multiform surveying measurements. These techniques have been successfully implemented into two projects, namely the Digital Mogao Grottos and the Chi Lin Nunnery reconstruction. Our results prove that the concept of and the techniques utilized in Digital Cultural Heritage can not only contribute to research, preservation, management, interpretation, and representation of cultural heritages but can also help resolve the conflicts between tourism and protection.

  2. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, B. Y. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); School of Physics and Optoelectronic Technology, Dalian University of Technology, Dalian 116023 (China); Yao, B. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); State Key Laboratory of Superhard Material, Department of Physics, Jilin University, Changchun 130023 (China); Li, Y. F.; Xing, G. Z. [State Key Laboratory of Superhard Material, Department of Physics, Jilin University, Changchun 130023 (China); Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore); Liu, A. M. [School of Physics and Optoelectronic Technology, Dalian University of Technology, Dalian 116023 (China); Zhang, Z. Z.; Li, B. H.; Zhao, D. X.; Shan, C. X.; Shen, D. Z. [Key Laboratory of Excited State Process, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Science, Changchun 130033 (China); Wu, T. [Division of Physics and Applied Physics, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371 (Singapore); Qin, X. B. [Key Laboratory of Nuclear Analysis Techniques, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049 (China)

    2011-10-31

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to V{sub Zn}, such as V{sub Zn} and Li{sub i}-N{sub O}-V{sub Zn} complex, well supported by first-principles calculations. The incorporation of N{sub O} can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Li{sub i} to form Li{sub i}-N{sub O} complex, which restrains the compensation of Li{sub i} for V{sub Zn} and makes the ZnO:(Li, N) conduct in p-type.

  3. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    International Nuclear Information System (INIS)

    Zhang, B. Y.; Yao, B.; Li, Y. F.; Xing, G. Z.; Liu, A. M.; Zhang, Z. Z.; Li, B. H.; Zhao, D. X.; Shan, C. X.; Shen, D. Z.; Wu, T.; Qin, X. B.

    2011-01-01

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to V Zn , such as V Zn and Li i -N O -V Zn complex, well supported by first-principles calculations. The incorporation of N O can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Li i to form Li i -N O complex, which restrains the compensation of Li i for V Zn and makes the ZnO:(Li, N) conduct in p-type.

  4. Evidence of cation vacancy induced room temperature ferromagnetism in Li-N codoped ZnO thin films

    Science.gov (United States)

    Zhang, B. Y.; Yao, B.; Li, Y. F.; Liu, A. M.; Zhang, Z. Z.; Li, B. H.; Xing, G. Z.; Wu, T.; Qin, X. B.; Zhao, D. X.; Shan, C. X.; Shen, D. Z.

    2011-10-01

    Room temperature ferromagnetism (RTFM) was observed in Li-N codoped ZnO thin films [ZnO:(Li, N)] fabricated by plasma-assisted molecular beam epitaxy, and p-type ZnO:(Li, N) shows the strongest RTFM. Positron annihilation spectroscopy and low temperature photoluminescence measurements indicate that the RTFM in ZnO:(Li, N) is attributed to the defect complex related to VZn, such as VZn and Lii-NO-VZn complex, well supported by first-principles calculations. The incorporation of NO can stabilize and enhance the RTFM of ZnO:(Li, N) by combining with Lii to form Lii-NO complex, which restrains the compensation of Lii for VZn and makes the ZnO:(Li, N) conduct in p-type.

  5. An Extension of the Lin-Kernighan-Helsgaun TSP Solver for Constrained Traveling Salesman and Vehicle Routing Problems

    DEFF Research Database (Denmark)

    Helsgaun, Keld

    This report describes the implementation of an extension of the Lin-Kernighan-Helsgaun TSP solver for solving constrained traveling salesman and vehicle routing problems. The extension, which is called LKH-3, is able to solve a variety of well-known problems, including the sequential ordering...... problem (SOP), the traveling repairman problem (TRP), variants of the multiple travel-ing salesman problem (mTSP), as well as vehicle routing problems (VRPs) with capacity, time windows, pickup-and-delivery and distance constraints. The implementation of LKH-3 builds on the idea of transforming...... the problems into standard symmetric traveling salesman problems and handling constraints by means of penalty functions. Extensive testing on benchmark instances from the literature has shown that LKH-3 is effective. Best known solutions are often obtained, and in some cases, new best solutions are found...

  6. ''SMILE'': A Self Magnetically Insulated Transmission LinE adder for the 8-stage RADLAC II accelerator

    International Nuclear Information System (INIS)

    Mazarakis, M.G.; Poukey, J.W.; Shope, S.L.; Frost, C.A.; Turman, B.N.; Ramirez, J.J.; Prestwich, K.R.; Pankuch, P.J.

    1991-01-01

    The RADLAC II Self Magnetically Insulated Transmission LinE ''SMILE'' is a coaxial wave guide structure that is composed of two regions: (a) a 9.5-m voltage adder and (b) a 3-m long extension section. The adder section provides for the addition of the input voltages from the individual water-dielectric pulse forming line feeds. The extension section isolates the adder from the magnetically immersed foilless diode electron source load and efficiently transports the pulsed power out from the deionized water tank of the device. The SMILE modification of the RADLAC II accelerator enabled us to produce high quality beams of up to 14 MV, 100 kA. The design and the experimental evaluation of SMILE will be presented and compared with numerical simulation predictions. 12 refs., 9 figs., 1 tab

  7. Expression and associations of TRAF1, BMI-1, ALDH1, and Lin28B in oral squamous cell carcinoma.

    Science.gov (United States)

    Wu, Tian-Fu; Li, Yi-Cun; Ma, Si-Rui; Bing-Liu; Zhang, Wen-Feng; Sun, Zhi-Jun

    2017-04-01

    Tumor necrosis factor receptor-associated factor 1, an adaptor protein of tumor necrosis factor 2, is involved in classical nuclear factor (NF)-κB activation and lymphocyte recruitment. However, less is known about the expression and association of tumor necrosis factor receptor-associated factor 1 with cancer stem cell markers in oral squamous cell carcinoma. This study aimed to investigate the expression of tumor necrosis factor receptor-associated factor 1 and stem cell characteristic markers (lin28 homolog B, B cell-specific Moloney murine leukemia virus integration site 1, and aldehyde dehydrogenase 1) in oral squamous cell carcinoma and analyze their relations. Paraffin-embedded tissues of 78 oral squamous cell carcinomas, 39 normal oral mucosa, and 12 oral dysplasia tissues were employed in tissue microarrays, and the expression of tumor necrosis factor receptor-associated factor 1, B cell-specific Moloney murine leukemia virus integration site 1, aldehyde dehydrogenase 1, and lin28 homolog B was measured by immunohistostaining and digital pathological analysis. The expression of tumor necrosis factor receptor-associated factor 1 was higher in the oral squamous cell carcinoma group as compared with the expression in the oral mucosa (p oral dysplasia (p oral squamous cell carcinoma. The patient survival rate was lower in the highly expressed tumor necrosis factor receptor-associated factor 1 group, although the difference was not significant. The clustering analysis showed that tumor necrosis factor receptor-associated factor 1 was most related to aldehyde dehydrogenase 1. These findings suggest that tumor necrosis factor receptor-associated factor 1 has potential direct/indirect regulations with the cancer stem cell markers in oral squamous cell carcinoma, which may help in further analysis of the cancer stem cell characteristics.

  8. Estonia's Big Boys' Club / Justin Petrone

    Index Scriptorium Estoniae

    Petrone, Justin, 1979-

    2007-01-01

    Eesti üliõpilasseltside ajaloost, liikmetest ning mõjust Eesti ühiskonnale ja poliitikale. Lähemalt Eesti Üliõpilaste Seltsist (EÜS), selle tekkest, taastamisest Gorbatšovi reformide aastail, liikmeskonnast, suhetest teiste korporatsioonidega. EÜSi liikmete hulka kuulub ka president Toomas Hendrik Ilves. Ajakirjanumbri esikaanel T.H. Ilvese foto

  9. 2009-IJBCS-Article- Justin Abadassi

    African Journals Online (AJOL)

    hp

    utilized as human food, animal feed and raw ... systems, their relatively low susceptibility to ... The present work was undertaken to ... Figure 1: Principal components analysis: Biplot showing the representation of variables and .... Table 2: Population means and their standard errors for earliness variables and plant and ear.

  10. Applying a Multiple Screening Program Aided by a Guideline-driven Computerized Decision Support System—A Pilot Experience in Yun-Lin, Taiwan

    Directory of Open Access Journals (Sweden)

    Jou-Wei Lin

    2007-01-01

    Conclusion: A computer-aided screening program driven by the US Preventive Services Task Force recommendations has been successfully implemented in Yun-Lin, Taiwan, and provided useful information about local epidemiology and implications for future health policy making. [J Formos Med Assoc 2007; 106(1:58-68

  11. Curcumin Inhibits LIN-28A through the Activation of miRNA-98 in the Lung Cancer Cell Line A549.

    Science.gov (United States)

    Liu, Wei-Lun; Chang, Jia-Ming; Chong, Inn-Wen; Hung, Yi-Li; Chen, Yung-Hsiang; Huang, Wen-Tsung; Kuo, Hsuan-Fu; Hsieh, Chong-Chao; Liu, Po-Len

    2017-06-03

    Metastasis is common in lung cancer and is associated with poor clinical outcomes and increased mortality. Curcumin is a natural anti-cancer agent that inhibits the metastasis of various cancers by modulating the expression of micro (mi) RNAs such as miR-98, which acts as a tumor suppressor. This study investigated the effect of curcumin on miR-98 expression and in vitro cell line growth and invasiveness in lung cancer. Curcumin treatment enhanced the expression of miR-98 and reduced that of the miR-98 target gene LIN28A as well as matrix metalloproteinase ( MMP ) 2 and MMP9 in vitro and in vivo. MiR-98 overexpression suppressed lung cancer cell migration and invasion by inhibiting LIN28A-induced MMP2 and MMP9 expression. Meanwhile, LIN28A level was downregulated by overexpression of miR-98 mimic. Induction of miR-98 by curcumin treatment suppressed MMP2 and MMP9 by targeting LIN28A. These findings provide insight into the mechanisms by which curcumin suppresses lung cancer cell line growth in vitro and in vivo and invasiveness in vitro.

  12. The gga-let-7 family post-transcriptionally regulates TGFBR1 and LIN28B during the differentiation process in early chick development.

    Science.gov (United States)

    Lee, Sang In; Jeon, Mi-Hyang; Kim, Jeom Sun; Jeon, Ik-Soo; Byun, Sung June

    2015-12-01

    Early chick embryogenesis is governed by a complex mechanism involving transcriptional and post-transcriptional regulation, although how post-transcriptional processes influence the balance between pluripotency and differentiation during early chick development have not been previously investigated. Here, we characterized the microRNA (miRNA) signature associated with differentiation in the chick embryo, and found that as expression of the gga-let-7 family increases through early development, expression of their direct targets, TGFBR1 and LIN28B, decreases; indeed, gga-let-7a-5p and gga-let-7b miRNAs directly bind to TGFBR1 and LIN28B transcripts. Our data further indicate that TGFBR1 and LIN28B maintain pluripotency by regulating POUV, NANOG, and CRIPTO. Therefore, gga-let-7 miRNAs act as post-transcriptional regulators of differentiation in blastodermal cells by repressing the expression of the TGFBR1 and LIN28B, which intrinsically controls blastodermal cell differentiation in early chick development. © 2015 Wiley Periodicals, Inc.

  13. The Many Sides of Happy Lim: aka Hom Ah Wing, Lin Jian Fu, Happy Lum, Lin Chien Fu, Hom Yen Chuck, Lam Kin Foo, Lum Kin Foo, Hom, Lim Goon Wing, Lim Gin Foo, Gin Foo Lin, Koon Wing Lim, Henry Chin, Lim Ying Chuck, Lim Ah Wing, et. al.

    Directory of Open Access Journals (Sweden)

    Gordon H. Chang

    2010-03-01

    Full Text Available

    Known to the FBI, INS, and IRS as Mr. Ah Wing Hom, he was also Lin Jian Fu, Jian Fu (Tough Guy, or just Fu to the readers of the many poems and short stories he published in Chinese over four decades in the twentieth century. And to still others, primarily English-readers of his writing, he was Happy Lim, an ironic, even tragically bizarre name, as his life was far from pleasant. On New Year's Day 1986, he died alone in a dingy San Francisco Chinatown bachelor hotel suffering from a bacterial infection and a chronic blood disorder that had required the amputation of all his toes the year before. He was seventy-eight years of age and had spent most of his life within blocks of where he died.

  14. Functional study of risk loci of stem cell-associated gene lin-28B and associations with disease survival outcomes in epithelial ovarian cancer.

    Science.gov (United States)

    Lu, Lingeng; Katsaros, Dionyssios; Mayne, Susan T; Risch, Harvey A; Benedetto, Chiara; Canuto, Emilie Marion; Yu, Herbert

    2012-11-01

    Several single-nucleotide polymorphisms (SNPs) of the stem cell-associated gene lin-28B have been identified in association with ovarian cancer and ovarian cancer-related risk factors. However, whether these SNPs are functional or might be potential biomarkers for ovarian cancer prognosis remains unknown. The purposes of this study were to investigate the functional relevance of the identified lin-28B SNPs, as well as the associations of genotype and phenotype with epithelial ovarian cancer (EOC) survival. We analyzed five SNPs and mRNA levels of lin-28B in 211 primary EOC tissues using Taqman(®) SNP genotyping assays and SYBR green-based real-time PCR, respectively. The RNA secondary structures at the region of a genome-wide association-identified intronic rs314276 were analyzed theoretically with mfold and experimentally with circular dichroism spectroscopy. We found that rs314276 was a cis-acting expression quantitative trait locus (eQTL) in both additive and dominant models, while rs7759938 and rs314277 were significant or of borderline significance in dominant models only. The rs314276 variant significantly affects RNA secondary structure. No SNPs alone were associated with patient survival. However, we found that among patients initially responding to chemotherapy, those with higher lin-28B expression had higher mortality risk (hazard ratio =3.27, 95% confidence interval: 1.63-6.56) and relapse risk (hazard ratio = 2.53, 95% confidence interval: 1.41-4.54) than those with lower expression, and these associations remained in multivariate analyses. These results suggest that rs314276 alters RNA secondary structure and thereby influences gene expression, and that lin-28B is a cancer stem cell-associated marker, which may be a pharmaceutical target in the management of EOC.

  15. CINCO VOZES NUM COTIDIANO DE SOMBRAS: “PENTÁGONO DE HAHN”, DE OSMAN LINS

    Directory of Open Access Journals (Sweden)

    Cícero Émerson do Nascimento Cardoso (URCA

    2013-11-01

    Full Text Available Este trabalho se pauta na análise da obra “Pentágono de Hahn”, que integra a obra “Nove, novena – narrativas”, de Osman Lins. A partir da chegada de um circo a uma cidade interiorana que apresenta, dentre seus espetáculos, a elefanta “Hahn”, cinco personagens expõem suas existências fadadas à brutalidade de um cotidiano “repleto” de vazios e experiências não vividas. O autor, nessa obra, arquiteta uma enredística polifônica que excede em lirismo, acuidade psicológica e catalogação de valores humanos indevassáveis o que a torna um profícuo objeto de estudo aberto às mais amplas incursões em se tratando de produção literária moderna.

    Palavras-chave: Modernismo; Narrativa moderna; Osman Lins.

  1. Tip 2 Diabetes Mellituslu Hastalarda Mikroalbuminüri, İnsülin Direnci ve Kardiyovasküler Risk

    OpenAIRE

    ERSOY, Canan; TAŞLI, Babürşah; YILDIZ, Abdülmecit; İMAMOĞLU, Şazi

    2006-01-01

    Son çalışmalar tip 2 diyabette mikroalbuminüri (MAU) varlığı ile hedef organ hasarları ve kardiyovasküler hastalık riski arasındaki ilişkilere yönelmişlerdir. Bu çalışmada, Tip 2 diabetes mellituslu (DM) hastalarda MAU ile glisemik kontrol, insülin direnci (İR) ve diğer kardiyovasküler risk faktörleri arasındaki ilişki değerlendirilmiştir. İnsülin gereksinimi olmayan, normal renal fonksiyonlu 29 mikroalbuminürik ve 68 normoalbuminürik tip 2 DM'lu hasta çalışmaya dahil edildi. Tüm hast...

  2. Lin- CD34hi CD117int/hi FcεRI+ cells in human blood constitute a rare population of mast cell progenitors.

    Science.gov (United States)

    Dahlin, Joakim S; Malinovschi, Andrei; Öhrvik, Helena; Sandelin, Martin; Janson, Christer; Alving, Kjell; Hallgren, Jenny

    2016-01-28

    Mast cells are rare tissue-resident immune cells that are involved in allergic reactions, and their numbers are increased in the lungs of asthmatics. Murine lung mast cells arise from committed bone marrow-derived progenitors that enter the blood circulation, migrate through the pulmonary endothelium, and mature in the tissue. In humans, mast cells can be cultured from multipotent CD34(+) progenitor cells. However, a population of distinct precursor cells that give rise to mast cells has remained undiscovered. To our knowledge, this is the first report of human lineage-negative (Lin(-)) CD34(hi) CD117(int/hi) FcεRI(+) progenitor cells, which represented only 0.0053% of the isolated blood cells in healthy individuals. These cells expressed integrin β7 and developed a mast cell-like phenotype, although with a slow cell division capacity in vitro. Isolated Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells had an immature mast cell-like appearance and expressed high levels of many mast cell-related genes as compared with human blood basophils in whole-transcriptome microarray analyses. Furthermore, serglycin, tryptase, and carboxypeptidase A messenger RNA transcripts were detected by quantitative reverse transcription-polymerase chain reaction. Altogether, we propose that the Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood cells are closely related to human tissue mast cells and likely constitute an immediate precursor population, which can give rise to predominantly mast cells. Furthermore, asthmatics with reduced lung function had a higher frequency of Lin(-) CD34(hi) CD117(int/hi) FcεRI(+) blood mast cell progenitors than asthmatics with normal lung function. © 2016 by The American Society of Hematology.

  3. Weak Activity of Haloalkane Dehalogenase LinB with 1,2,3-Trichloropropane Revealed by X-Ray Crystallography and Microcalorimetry▿

    OpenAIRE

    Monincová, Marta; Prokop, Zbyněk; Vévodová, Jitka; Nagata, Yuji; Damborský, Jiří

    2007-01-01

    1,2,3-Trichloropropane (TCP) is a highly toxic and recalcitrant compound. Haloalkane dehalogenases are bacterial enzymes that catalyze the cleavage of a carbon-halogen bond in a wide range of organic halogenated compounds. Haloalkane dehalogenase LinB from Sphingobium japonicum UT26 has, for a long time, been considered inactive with TCP, since the reaction cannot be easily detected by conventional analytical methods. Here we demonstrate detection of the weak activity (kcat = 0.005 s−1) of Li...

  4. Functional comparison of the nematode Hox gene lin-39 in C. elegans and P. pacificus reveals evolutionary conservation of protein function despite divergence of primary sequences

    OpenAIRE

    Grandien, Kaj; Sommer, Ralf J.

    2001-01-01

    Hox transcription factors have been implicated in playing a central role in the evolution of animal morphology. Many studies indicate the evolutionary importance of regulatory changes in Hox genes, but little is known about the role of functional changes in Hox proteins. In the nematodes Pristionchus pacificus and Caenorhabditis elegans, developmental processes can be compared at the cellular, genetic, and molecular levels and differences in gene function can be identified. The Hox gene lin-3...

  5. Qualidade de um sistema latossolo-argissolo como receptor de efluentes no município de Lins(SP Quality of a latosol-argisol system in the county of Lins/SP, Brazil

    Directory of Open Access Journals (Sweden)

    Liliane Ibrahim

    2008-12-01

    Full Text Available Este trabalho objetivou caracterizar um sistema de solos, evidenciando a propriedades que possam esclarecer sua dinâmica e contribuir para a definição de critérios que condicionem a aptidão destes solos como receptores de efluentes. Trata-se de uma área experimental de estudos, contígua à Estação de Tratamento de Esgoto do município de Lins (SP, onde o efluente é gerado a partir do tratamento de esgoto por sistema de lagoas de estabilização. Os solos, situados ao longo de uma vertente com ligeira inclinação, foram caracterizados por meio de análises, morfológica, granulométrica, química, mineralógica e micromorfológica, realizadas em amostras coletadas em cinco trincheiras em toposseqüência. Os solos são desenvolvidos a partir dos sedimentos arenosos da Formação Adamantina (Grupo Bauru e constituem um sistema Latossolo - Argissolo onde a transição Bw - Bt ocorre lateralmente do topo para a base da vertente. Foram identificadas três fases pedogenéticas nesta associação de solos. A primeira, argiluviação e adensamento de partículas, responsável pela formação dos horizontes texturais, foi superposta pelos processos de latossolização e hidromorfismo, atuantes na dinâmica atual destes solos. Análises micromorfológicas mostraram tratar-se de solos com intensa porosidade, caracterizada pelo empilhamento dos grãos do esqueleto quartzoso amplamente predominante e pelo arranjo entre os microagregados granulares. A permeabilidade é ainda favorecida pela intensa ação da mesofauna. Os solos são distróficos e compostos por caulinita e óxidos de Fe na fração argilosa. Por constituírem um sistema frágil, a disposição de quaisquer tipos de resíduos nestes solos requer o monitoramento constante de suas propriedades, tanto para a manutenção, quanto para a recuperação da qualidade desta cobertura pedológica.The purpose of this study was the characterization of a soil system, focused on proprieties that

  6. Properties of the fullerene C_6_0-containing PN Lin49 in the SMC; Explanations of strong near-IR excess

    International Nuclear Information System (INIS)

    Otsuka, Masaaki; Kemper, Francisca; Leal-Ferreira, Marcelo L.; Aleman, Isabel; Ochsendorf, Bram; Bernard-Salas, Jeronimo; Cami, Jan; Peeters, Els

    2016-01-01

    We performed a detailed spectroscopic analysis of the fullerene C_6o-containing planetary nebula (PN) Lin49 in the Small Magellanic Cloud (SMC). Lin49 is a C-rich and metal- deficient PN (Z∼⃒0.0006) and its nebular abundances are in agreement with the AGB model for the initially 1.25M_☉ stars with the metallicity Z = 0.001 of Fishlock et al. (2014, [1]). By stellar absorption fitting with TLUSTY, we derived stellar abundances, effective temperature, and surface gravity. We constructed the photo-ionization model with CLOUDY in order to investigate physical conditions of Lin49. The model with the 0.005-0.1 μm radius graphite and a constant hydrogen density shell could not fit the ∼⃒1-5 μm SED owing to the strong near-IR excess. We propose that the near-IR excess indicates (1) the presence of extremely small carbon molecules or (2) the presence of high-density structure surrounding the central star. (paper)

  7. Initial results on computational performance of Intel Many Integrated Core (MIC) architecture: implementation of the Weather and Research Forecasting (WRF) Purdue-Lin microphysics scheme

    Science.gov (United States)

    Mielikainen, Jarno; Huang, Bormin; Huang, Allen H.

    2014-10-01

    Purdue-Lin scheme is a relatively sophisticated microphysics scheme in the Weather Research and Forecasting (WRF) model. The scheme includes six classes of hydro meteors: water vapor, cloud water, raid, cloud ice, snow and graupel. The scheme is very suitable for massively parallel computation as there are no interactions among horizontal grid points. In this paper, we accelerate the Purdue Lin scheme using Intel Many Integrated Core Architecture (MIC) hardware. The Intel Xeon Phi is a high performance coprocessor consists of up to 61 cores. The Xeon Phi is connected to a CPU via the PCI Express (PICe) bus. In this paper, we will discuss in detail the code optimization issues encountered while tuning the Purdue-Lin microphysics Fortran code for Xeon Phi. In particularly, getting a good performance required utilizing multiple cores, the wide vector operations and make efficient use of memory. The results show that the optimizations improved performance of the original code on Xeon Phi 5110P by a factor of 4.2x. Furthermore, the same optimizations improved performance on Intel Xeon E5-2603 CPU by a factor of 1.2x compared to the original code.

  8. Effects of gamma radiation on various stages in the life cycle of meal worm, Tenebrio molitor Lin

    International Nuclear Information System (INIS)

    Chiravathanapong, S.; Segsarnviriya, S.

    1984-12-01

    Effect of gamma radiation on each growth stage of meal worm (Tenebrio molitor Lin.) were conducted at 27+-2 0 C and 75+-2% relative humidity. LD 50 and LD 99 of 5-day old eggs at 5 days after irradiation were 76 and 367 gray. The survived larvae could live no longer than 5 days and seldom moved or without feeding. LD 50 and LD 99 of last instar larvae at 10 days after irradiation were 662 and 1,367 gray. No pupation occurred in larvae after irradiation. Dead larvae caused by radiation turned blackish, liquid oozed out from the body, and survived no longer than 5 days. Some irradiated larvae had incomplete molting and died. LD 50 and LD 99 of 6-day-old pupae at 3 days after irradiation were 874 and 1,492 gray. Abnormal irradiated pupae, some abnormal pupae were underdeveloped wing and abdominal pupal characteristic was still remained. Pupal legs could develop to adult legs only and could survive no longer than 1 week. Unfortunately pupae irradiated at low dosage of radiation would develop to be complete adult head, but could survive no longer than 2 weeks with slow movement and no oviposition. LD 50 of male adults and female adults was checked in 7 days postirradiation and it was estimated as 788 and 786 gray while LD 99 was estimated as 1,375 and 1,350 gray respectively. Results of male adults and female adults checking in 10 days post-irradiation found that LD 50 was estimated as 533 and 598 gray and LD 99 was estimated as 1,227 and 1,229 gray respectively. The remained survivors of both sexes could survive no longer than 10 days without feeding and mating

  9. Lithology identification of aquifers from geophysical well logs and fuzzy logic analysis: Shui-Lin Area, Taiwan

    Science.gov (United States)

    Hsieh, Bieng-Zih; Lewis, Charles; Lin, Zsay-Shing

    2005-04-01

    The purpose of this study is to construct a fuzzy lithology system from well logs to identify formation lithology of a groundwater aquifer system in order to better apply conventional well logging interpretation in hydro-geologic studies because well log responses of aquifers are sometimes different from those of conventional oil and gas reservoirs. The input variables for this system are the gamma-ray log reading, the separation between the spherically focused resistivity and the deep very-enhanced resistivity curves, and the borehole compensated sonic log reading. The output variable is groundwater formation lithology. All linguistic variables are based on five linguistic terms with a trapezoidal membership function. In this study, 50 data sets are clustered into 40 training sets and 10 testing sets for constructing the fuzzy lithology system and validating the ability of system prediction, respectively. The rule-based database containing 12 fuzzy lithology rules is developed from the training data sets, and the rule strength is weighted. A Madani inference system and the bisector of area defuzzification method are used for fuzzy inference and defuzzification. The success of training performance and the prediction ability were both 90%, with the calculated correlation of training and testing equal to 0.925 and 0.928, respectively. Well logs and core data from a clastic aquifer (depths 100-198 m) in the Shui-Lin area of west-central Taiwan are used for testing the system's construction. Comparison of results from core analysis, well logging and the fuzzy lithology system indicates that even though the well logging method can easily define a permeable sand formation, distinguishing between silts and sands and determining grain size variation in sands is more subjective. These shortcomings can be improved by a fuzzy lithology system that is able to yield more objective decisions than some conventional methods of log interpretation.

  10. Gene expression profile and functionality of ESC-derived Lin-ckit+Sca-1+ cells are distinct from Lin-ckit+Sca-1+ cells isolated from fetal liver or bone marrow.

    Directory of Open Access Journals (Sweden)

    Irina Fernandez

    Full Text Available In vitro bioreactor-based cultures are being extensively investigated for large-scale production of differentiated cells from embryonic stem cells (ESCs. However, it is unclear whether in vitro ESC-derived progenitors have similar gene expression profiles and functionalities as their in vivo counterparts. This is crucial in establishing the validity of ESC-derived cells as replacements for adult-isolated cells for clinical therapies. In this study, we compared the gene expression profiles of Lin-ckit+Sca-1+ (LKS cells generated in vitro from mouse ESCs using either static or bioreactor-based cultures, with that of native LKS cells isolated from mouse fetal liver (FL or bone marrow (BM. We found that in vitro-generated LKS cells were more similar to FL- than to BM LKS cells in gene expression. Further, when compared to cells derived from bioreactor cultures, static culture-derived LKS cells showed fewer differentially expressed genes relative to both in vivo LKS populations. Overall, the expression of hematopoietic genes was lower in ESC-derived LKS cells compared to cells from BM and FL, while the levels of non-hematopoietic genes were up-regulated. In order to determine if these molecular profiles correlated with functionality, we evaluated ESC-derived LKS cells for in vitro hematopoietic-differentiation and colony formation (CFU assay. Although static culture-generated cells failed to form any colonies, they did differentiate into CD11c+ and B220+ cells indicating some hematopoietic potential. In contrast, bioreactor-derived LKS cells, when differentiated under the same conditions failed to produce any B220+ or CD11c+ cells and did not form colonies, indicating that these cells are not hematopoietic progenitors. We conclude that in vitro culture conditions significantly affect the transcriptome and functionality of ESC-derived LKS cells and although in vitro differentiated LKS cells were lineage negative and expressed both ckit and Sca-1

  11. ALLIUM HOOKERII LIN

    African Journals Online (AJOL)

    Toshiba

    increase the food supply and add variety to the diet [5]. ... available in the Himalayan range including Nepal, China [6]. ... altitude, between 93.42oE to 94.47oE longitude and between 23.83 o ... The leaf decoction (Decoction is a method of extraction, by boiling, or ..... Dry fish washed in water are fried in a small amount of.

  12. Lin Simpson | NREL

    Science.gov (United States)

    technology areas that included: nanotechnology, nanomaterials, thin-film photovoltaics, thin-film processing , and program management. This includes extensive experience in nanotechnology, materials science B.S., Engineering Physics, Colorado School of Mines. Thesis: Spatial filtering for pattern recognition

  13. Temporal variation and source identification of black carbon at Lin'an and Longfengshan regional background stations in China

    Science.gov (United States)

    Cheng, Siyang; Wang, Yaqiang; An, Xingqin

    2017-12-01

    Black carbon (BC) is a component of fine particulate matter (PM2.5), associated with climate, weather, air quality, and people's health. However, studies on temporal variation of atmospheric BC concentration at background stations in China and its source area identification are lacking. In this paper, we use 2-yr BC observations from two background stations, Lin'an (LAN) and Longfengshan (LFS), to perform the investigation. The results show that the mean diurnal variation of BC has two significant peaks at LAN while different characteristics are found in the BC variation at LFS, which are probably caused by the difference in emission source contributions. Seasonal variation of monthly BC shows double peaks at LAN but a single peak at LFS. The annual mean concentrations of BC at LAN and LFS decrease by 1.63 and 0.26 μg m-3 from 2009 to 2010, respectively. The annual background concentration of BC at LAN is twice higher than that at LFS. The major source of the LAN BC is industrial emission while the source of the LFS BC is residential emission. Based on transport climatology on a 7-day timescale, LAN and LFS stations are sensitive to surface emissions respectively in belt or approximately circular area, which are dominated by summer monsoon or colder land air flows in Northwest China. In addition, we statistically analyze the BC source regions by using BC observation and FLEXible PARTicle dispersion model (FLEXPART) simulation. In summer, the source regions of BC are distributed in the northwest and south of LAN and the southwest of LFS. Low BC concentration is closely related to air mass from the sea. In winter, the source regions of BC are concentrated in the west and south of LAN and the northeast of the threshold area of s tot at LFS. The cold air mass in the northwest plays an important role in the purification of atmospheric BC. On a yearly scale, sources of BC are approximately from five provinces in the northwest/southeast of LAN and the west of LFS. These

  14. N-Myc regulates expression of pluripotency genes in neuroblastoma including lif, klf2, klf4, and lin28b.

    Directory of Open Access Journals (Sweden)

    Rebecca Cotterman

    2009-06-01

    Full Text Available myc genes are best known for causing tumors when overexpressed, but recent studies suggest endogenous myc regulates pluripotency and self-renewal of stem cells. For example, N-myc is associated with a number of tumors including neuroblastoma, but also plays a central role in the function of normal neural stem and precursor cells (NSC. Both c- and N-myc also enhance the production of induced pluripotent stem cells (iPSC and are linked to neural tumor stem cells. The mechanisms by which myc regulates normal and neoplastic stem-related functions remain largely open questions. Here from a global, unbiased search for N-Myc bound genes using ChIP-chip assays in neuroblastoma, we found lif as a putative N-Myc bound gene with a number of strong N-Myc binding peaks in the promoter region enriched for E-boxes. Amongst putative N-Myc target genes in expression microarray studies in neuroblastoma we also found lif and three additional important embryonic stem cell (ESC-related factors that are linked to production of iPSC: klf2, klf4, and lin28b. To examine the regulation of these genes by N-Myc, we measured their expression using neuroblastoma cells that contain a Tet-regulatable N-myc transgene (TET21N as well as NSC with a nestin-cre driven N-myc knockout. N-myc levels closely correlated with the expression of all of these genes in neuroblastoma and all but lif in NSC. Direct ChIP assays also indicate that N-Myc directly binds the lif promoter. N-Myc regulates trimethylation of lysine 4 of histone H3 in the promoter of lif and possibly in the promoters of several other stem-related genes. Together these findings indicate that N-Myc regulates overlapping stem-related gene expression programs in neuroblastoma and NSC, supporting a novel model by which amplification of the N-myc gene may drive formation of neuroblastoma. They also suggest mechanisms by which Myc proteins more generally contribute to maintenance of pluripotency and self-renewal of ESC as

  15. Cell type-specific recruitment of Drosophila Lin-7 to distinct MAGUK-based protein complexes defines novel roles for Sdt and Dlg-S97.

    Science.gov (United States)

    Bachmann, André; Timmer, Marco; Sierralta, Jimena; Pietrini, Grazia; Gundelfinger, Eckart D; Knust, Elisabeth; Thomas, Ulrich

    2004-04-15

    Stardust (Sdt) and Discs-Large (Dlg) are membrane-associated guanylate kinases (MAGUKs) involved in the organization of supramolecular protein complexes at distinct epithelial membrane compartments in Drosophila. Loss of either Sdt or Dlg affects epithelial development with severe effects on apico-basal polarity. Moreover, Dlg is required for the structural and functional integrity of synaptic junctions. Recent biochemical and cell culture studies have revealed that various mammalian MAGUKs can interact with mLin-7/Veli/MALS, a small PDZ-domain protein. To substantiate these findings for their in vivo significance with regard to Sdt- and Dlg-based protein complexes, we analyzed the subcellular distribution of Drosophila Lin-7 (DLin-7) and performed genetic and biochemical assays to characterize its interaction with either of the two MAGUKs. In epithelia, Sdt mediates the recruitment of DLin-7 to the subapical region, while at larval neuromuscular junctions, a particular isoform of Dlg, Dlg-S97, is required for postsynaptic localization of DLin-7. Ectopic expression of Dlg-S97 in epithelia, however, was not sufficient to induce a redistribution of DLin-7. These results imply that the recruitment of DLin-7 to MAGUK-based protein complexes is defined by cell-type specific mechanisms and that DLin-7 acts downstream of Sdt in epithelia and downstream of Dlg at synapses.

  16. Les vélins du Muséum national d’histoire naturelle : une collection mise en lumière

    OpenAIRE

    Cardinal, Catherine

    2018-01-01

    Une exposition unique au Cabinet d’histoire du Jardin des plantes Très rarement, le public a pu voir la collection d’images de fleurs, de plantes, d’oiseaux et de mammifères, déposée à la bibliothèque centrale du Musée national d’histoire naturelle. La fragilité des peintures sur vélin au contact de l’air humide et de la lumière explique les précautions prises à leur égard. L’exposition d’environ cent cinquante pièces au sein du Cabinet d’histoire, d’octobre 2016 à janvier 2017, a donc consti...

  17. Efeito e modo de ação das bacteriocinas produzidas por Lactococcus lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 contra Listeria innocua LIN 11 Effect and mode of action of the bacterioncin produced by Lactococcus. lactis subsp. lactis ITAL 383, ATCC 11454 e CNRZ 150 against Listeria innocua LIN 11

    Directory of Open Access Journals (Sweden)

    Izildinha MORENO

    1999-01-01

    Full Text Available O efeito e o modo de ação das bacteriocinas produzidas por L. lactis subsp. lactis ITAL 383 e CNRZ 150 são similares à nisina de L. lactis subsp. lactis ATCC 11454. Estas bacteriocinas apresentaram um modo de ação bactericida, causando a lise de células de L. innocua LIN 11, associada ao decréscimo da absorbância e da viabilidade celular. O efeito letal foi maior para células em fase exponencial comparativamente à fase estacionária de crescimento. A adsorção dessas bacteriocinas às células de L. innocua LIN 11 foi muito rápida e influenciada pelo pH do meio de suspensão; adsorção máxima foi verificada a pH 6,0 e logo após o contato inicial. Perda completa de adsorção ocorreu em pH 2,0.The effect and mode of action of the bacteriocin produced by L. lactis subsp. lactis ITAL 383 and CNRZ 150 are similar to the nisin produced by L. lactis subsp. lactis ATCC 11454. It was clearly bactericidal, and caused lysis of a strain of L. innocua LIN 11 detected by the decrease of absorbance values and the cell viability. Their lethal effect was considerably higher during the logarithmic growth when compared to the stationary phase. Adsorption developed rapidly and was influenced by the pH value of the suspension medium. Maximum adsorption was observed at pH 6,0 and immediately after initial contact and loss at pH 2,0.

  18. Formation of positive cluster ions Li(n) Br (n = 2-7) and ionization energies studied by thermal ionization mass spectrometry.

    Science.gov (United States)

    Veličković, S R; Đustebek, J B; Veljković, F M; Veljković, M V

    2012-05-01

    Clusters of the type Li(n)X (X = halides) can be considered as potential building blocks of cluster-assembly materials. In this work, Li(n)Br (n = 2-7) clusters were obtained by a thermal ionization source of modified design and selected by a magnetic sector mass spectrometer. Positive ions of the Li(n)Br (n = 4-7) cluster were detected for the first time. The order of ion intensities was Li(2)Br(+) > Li(4)Br(+) > Li(5)Br(+) > Li(6)Br(+) > Li(3)Br(+). The ionization energies (IEs) were measured and found to be 3.95 ± 0.20 eV for Li(2)Br, 3.92 ± 0.20 eV for Li(3)Br, 3.93 ± 0.20 eV for Li(4)Br, 4.08 ± 0.20 eV for Li(5)Br, 4.14 ± 0.20 eV for Li(6)Br and 4.19 ± 0.20 eV for Li(7)Br. All of these clusters have a much lower ionization potential than that of the lithium atom, so they belong to the superalkali class. The IEs of Li(n)Br (n = 2-4) are slightly lower than those in the corresponding small Li(n) or Li(n)H clusters, whereas the IEs of Li(n)Br are very similar to those of Li(n) or Li(n)H for n = 5 and 6. The thermal ionization source of modified design is an important means for simultaneously obtaining and measuring the IEs of Li(n)Br (n = 2-7) clusters (because their ions are hermodynamically stable with respect to the loss of lithium atoms in the gas phase) and increasingly contributes toward the development of clusters for practical applications. Copyright © 2012 John Wiley & Sons, Ltd.

  19. Quando "falha a fala" e "fala a bala": lingua(gem e violência em Cidade de Deus, de Paulo Lins

    Directory of Open Access Journals (Sweden)

    Rita Gabrielli Pereira

    2018-04-01

    Full Text Available Cidade de Deus traz em si a história da construção do conjunto habitacional, cujo nome intitula o romance, e de sua transformação em uma das favelas mais violentas do Rio de Janeiro, por meio do entrecruzamento das histórias de Cabeleira, Bené, Zé Pequeno e Busca-Pé. Concebendo o romance, nos atos da escrita e da leitura, como uma enunciação (BENVENISTE, 1989a; 1989b; 1995a; 1995b entre autor e leitor, constituída por outras enunciações — entre narrador e narratário e entre personagens — a partir do "ato ficcional" (ISER, 2002 do autor, vamos nos guiar por essa tessitura de/entre histórias para rastrear o modo como Lins relaciona linguagem e violência. Palavras-chave: Lingua(gem, Subjetividade, Violência ______________________________ Cidade de Deus tells the history of the construction of the housing complex that entitles the novel and its transformation process into one of the most violent slums of Rio de Janeiro. By treating the novel as an enunciation (BENVENISTE, 1989a; 1989b; 1995a; 1995b between author and reader, which is made of other enunciations − between narrator and narratee and between characters −, based on the author´s “fictional act”(ISER, 2002, we intend to analyze the way how Lins relates language and violence. Keywords: Language, Subjectivity, Violence.

  20. A substrate specificity-determining unit of three Lin12-Notch repeat modules is formed in trans within the pappalysin-1 dimer and requires a sequence stretch C-terminal to the third module

    DEFF Research Database (Denmark)

    Weyer, Kathrin; Boldt, Henning B; Poulsen, Christine B

    2007-01-01

    -A cleaves IGFBP-4 and IGFBP-5, whereas PAPP-A2 cleaves only IGFBP-5. The pappalysins contain three Lin12-Notch repeat (LNR1-3) modules, previously considered unique to the Notch receptor family in which they function to regulate receptor cleavage. In contrast to the Notch receptor where three LNR modules...

  1. The Story of Heathcliff’s Journey Back to Wuthering Heights de Lin Haire-Sargeant (1992, ou le « deux en un » de la ré-écriture The Story of Heathcliff’s Journey Back to Wuthering Heights by Lin Haire-Sargeant (1992, and a “Two in one” Rewrite

    Directory of Open Access Journals (Sweden)

    Isabelle Roblin

    2009-10-01

    Full Text Available Lin Haire-Sargeant’s 1992 novel The Story of Heathcliff’s Journey Back to Wuthering Heights is typical of the interest shown by contemporary American writers in Victorian novels. It could indeed be classified doubly as a “retro-Victorian novel” since it partly re-writes not only Emily Brontë’s most famous novel, Wuthering Heights, as the title points out, but also, somewhat less obviously, Charlotte Brontë’s Jane Eyre. We will study in this article how Lin Haire-Sargeant’s attempt at re-writing highlights the usual aims of the retro-Victorian novel: taking advantage of the blanks left by the source novels to propose to the reader a modern critical approach, while at the same time being as faithful as possible to the writing conventions of the 19th century, and suggesting another point of view on a well-known story, through a postmodern mixing of historical and fictive characters.

  2. Iodine Deficiency in a Study Population of Norwegian Pregnant Women-Results from the Little in Norway Study (LiN).

    Science.gov (United States)

    Dahl, Lisbeth; Wik Markhus, Maria; Sanchez, Perla Vanessa Roldan; Moe, Vibeke; Smith, Lars; Meltzer, Helle Margrete; Kjellevold, Marian

    2018-04-20

    Iodine sufficiency is particularly important in pregnancy, where median urinary iodine concentration (UIC) in the range of 150⁻250 µg/L indicates adequate iodine status. The aims of this study were to determine UIC and assess if dietary and maternal characteristics influence the iodine status in pregnant Norwegian women. The study comprises a cross-sectional population-based prospective cohort of pregnant women (Little in Norway (LiN)). Median UIC in 954 urine samples was 85 µg/L and 78.4% of the samples ( n = 748) were ≤150 µg/L. 23.2% ( n = 221) of the samples were ≤50 µg/L and 5.2% ( n = 50) were above the requirements of iodine intake (>250 µg/L). Frequent iodine-supplement users ( n = 144) had significantly higher UIC (120 µg/L) than non-frequent users (75 µg/L). Frequent milk and dairy product consumers (4⁻9 portions/day) had significantly higher UIC (99 µg/L) than women consuming 0⁻1 portion/day (57 µg/L) or 2⁻3 portions/day (83 µg/L). Women living in mid-Norway ( n = 255) had lowest UIC (72 µg/L). In conclusion, this study shows that the diet of the pregnant women did not necessarily secure a sufficient iodine intake. There is an urgent need for public health strategies to secure adequate iodine nutrition among pregnant women in Norway.

  3. A Hydrological Tomography Collocated with Time-varying Gravimetry for Hydrogeology -An Example in Yun-Lin Alluvial Plain and Ming-Ju Basin in Taiwan

    Science.gov (United States)

    Chen, K. H.; Cheng, C. C.; Hwang, C.

    2016-12-01

    A new inversion technique featured by the collocation of hydrological modeling and gravimetry observation is presented in this report. Initially this study started from a project attempting to build a sequence of hydrodynamic models of ground water system, which was applied to identify the supplement areas of alluvial plains and basins along the west coast of Taiwan. To calibrate the decent hydro-geological parameters for the modeling, geological evolution were carefully investigated and absolute gravity observations, along with other on-site hydrological monitoring data were specially introduced. It was discovered in the data processing that the time-varying gravimetrical data are highly sensitive to certain boundary conditions in the hydrodynamic model, which are correspondent with respective geological features. A new inversion technique coined by the term "hydrological tomography" is therefore developed by reversing the boundary condition into the unknowns to be solved. An example of accurate estimate for water storage and precipitation infiltration of a costal alluvial plain Yun-Lin is presented. In the mean time, the study of an anticline structure of the upstream basin Ming-Ju is also presented to demonstrate how a geological formation is outlined when the gravimetrical data and hydrodynamic model are re-directed into an inversion.

  4. Uso agrícola de esgoto tratado em lagoas de estabilização:experiências do Pprosab* em Lins – SP

    Directory of Open Access Journals (Sweden)

    Fernando Mendonça Campos

    2004-01-01

    Full Text Available A Pilot Plant to treat the effluent from SABESP´s Wastewater Treatment Plant (Stabilization Pond System located at Lins was built within a six-hectare area adjacent to the Treatment Plant. The study focused on agricultural applications of the final treated effluent. Additional unit operations for wastewater treatment were constructed – namely hypochlorite disinfection, UV light disinfection and ozonation units. The final effluent from the Pilot Plant was applied in crop irrigation – namely coffee, corn and bean crops and the feeding system was by drop irrigation. Additionally, a fraction of the final treated effluent fed a hydrophonic system installed in vases, in which chrysanthemum and Gypsophila were cultivated. A third feeding line supplied a fish tank in which Oreochromis Niloticus were grown. A number of physical, chemical and biological variables were utilized for quality control of effluent streams at the various treatment stages, to monitor the cultivated crops and the soil, as well as agricultural parameters to identify growth characteristics. For all the cases under study there were conventional mode crops in parallel, acting as controls or references. The results obtained showed that the pond effluent, besides the hydraulic capacity itself, contained nutrients that are adequate for agricultural purposes, with significant savings associated. Additionally, such applications in irrigation avoid the eutrophication of natural water bodies

  5. Source apportionment of PM2.5 at the Lin'an regional background site in China with three receptor models

    Science.gov (United States)

    Deng, Junjun; Zhang, Yanru; Qiu, Yuqing; Zhang, Hongliang; Du, Wenjiao; Xu, Lingling; Hong, Youwei; Chen, Yanting; Chen, Jinsheng

    2018-04-01

    Source apportionment of fine particulate matter (PM2.5) were conducted at the Lin'an Regional Atmospheric Background Station (LA) in the Yangtze River Delta (YRD) region in China from July 2014 to April 2015 with three receptor models including principal component analysis combining multiple linear regression (PCA-MLR), UNMIX and Positive Matrix Factorization (PMF). The model performance, source identification and source contribution of the three models were analyzed and inter-compared. Source apportionment of PM2.5 was also conducted with the receptor models. Good correlations between the reconstructed and measured concentrations of PM2.5 and its major chemical species were obtained for all models. PMF resolved almost all masses of PM2.5, while PCA-MLR and UNMIX explained about 80%. Five, four and seven sources were identified by PCA-MLR, UNMIX and PMF, respectively. Combustion, secondary source, marine source, dust and industrial activities were identified by all the three receptor models. Combustion source and secondary source were the major sources, and totally contributed over 60% to PM2.5. The PMF model had a better performance on separating the different combustion sources. These findings improve the understanding of PM2.5 sources in background region.

  6. Evaluación preclínica y estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin

    Directory of Open Access Journals (Sweden)

    A. Lagarto

    2014-12-01

    Full Text Available El objetivo del presente trabajo fue la evaluación preclínica y el estudio de estabilidad de extractos a partir del follaje de Momordica charantia Lin. Se obtuvieron extractos acuoso e hidroalcohólico para los cuales se establecieron las especificaciones de calidad mediante la evaluación de tres lotes y se estudió su estabilidad por el método de vida de estante durante 12 meses. A los extractos se le evaluó el potencial genotóxico mediante ensayos de micronúcleos en médula ósea de ratón y aberraciones cromosómicas en linfocitos de sangre periférica. La actividad hipoglicemiante oral fue evaluada en animales con hiperglicemia temporal inducida por carga de glucosa. Como resultados se establecieron las especificaciones de calidad de los extractos acuoso e hidroalcohólico, los mismos mostraron estabilidad por 6 meses para el extracto acuoso y 12 meses para el extracto hidroalcohólico. No mostraron efecto genotóxico en los ensayos evaluados y mostraron efecto hipoglicemiante oral a la dosis de 450 mg/kg.

  7. Stepwise dissection and visualization of the catalytic mechanism of haloalkane dehalogenase LinB using molecular dynamics simulations and computer graphics.

    Science.gov (United States)

    Negri, Ana; Marco, Esther; Damborsky, Jiri; Gago, Federico

    2007-10-01

    The different steps of the dehalogenation reaction carried out by LinB on three different substrates have been characterized using a combination of quantum mechanical calculations and molecular dynamics simulations. This has allowed us to obtain information in atomic detail about each step of the reaction mechanism, that is, substrate entrance and achievement of the near-attack conformation, transition state stabilization within the active site, halide stabilization, water molecule activation and subsequent hydrolytic attack on the ester intermediate with formation of alcohol, and finally product release. Importantly, no bias or external forces were applied during the whole procedure so that both intermediates and products were completely free to sample configuration space in order to adapt to the plasticity of the active site and/or search for an exit. Differences in substrate reactivity were found to be correlated with the ease of adopting the near-attack conformation and two different exit pathways were found for product release that do not interfere with substrate entrance. Additional support for the different entry and exit pathways was independently obtained from an examination of the enzyme's normal modes.

  8. An attempt of using soil grain size in calculating the capacity of water unavailable to plants / Próba wykorzystania uziarnienia gleby do obliczania zawartości wody niedostępnej dla roślin

    Directory of Open Access Journals (Sweden)

    Brogowski Zygmunt

    2015-03-01

    Full Text Available Celem pracy była próba znalezienia możliwości obliczenia ilości wody niedostępnej dla roślin na podstawie uziarnienia gleb. Frakcje o średnicach <0,02 mm gromadzą od 90,1 do 98,8% całkowitej ilości wody niedostępnej dla roślin, a frakcja iłu koloidalnego (<0,002 mm zatrzymuje od 52,1 do 80,1% tej wody. Gromadzenie wody we frakcjach <0,02 mm znacząco zależy od ich składu mineralogicznego. Obecność we frakcjach illitu, chlorytu oraz kaolinitu powoduje zmniejszenie ilości wody niedostępnej nawet o 40% w stosunku do frakcji zbudowanych ze smektytów, wermikulitów oraz próchnicy. Ze względu na duże zróżnicowanie ilości wody niedostępnej dla roślin w poszczególnych frakcjach granulometrycznych <0,02 mm wynikaj¹ce ze zróżnicowania mineralogicznego tych frakcji nie udało się wyprowadzić współczynników pozwalających na obliczenie ilościowe w glebach wody niedostępnej dla roślin wiązanej w mikroporach <0,2 μm.

  9. M. TEMU-JUSTIN*', PG RISHA', YG MLAVWASI

    African Journals Online (AJOL)

    with the objective of promoting the efficient management of drug supply especially in the developing countries. Tanzania launched EDP in 1983 [I]. In addition to addressing the selection and procurement in the drug supply chain, a lot of effort has been put on training healthcare providers on the concept of rational drug use.

  10. Dialoogid kohatusest / Justin Ions ; tõlkinud Katrin Kivimaa

    Index Scriptorium Estoniae

    Ions, Justin

    2009-01-01

    Rahvusvaheline näitus "thisPLACEd" ("Kohatute koht") Tallinna Linnagaleriis 1. märtsini. Kuraatorid Silvina Der-Meguerditchian ja Reet Varblane. Suur osa näitusel osalevatest kunstnikest on armeenia päritolu. Koostöösse on kaasatud Eestiga seotud kunstnikud Olga Jürgenson (elab Londonis) ja Eléonore de Montesquiou

  11. Justin Bieber Featuring Slipknot: Consumption as Mode of Production

    OpenAIRE

    Brøvig-Hanssen, Ragnhild

    2016-01-01

    The chapter is taken from the book: The Oxford Handbook of Music and Virtuality edited by Sheila Whiteley and Shara Rambarran, 2016, reproduced by permission of Oxford University Press https://doi.org/10.1093/oxfordhb/9780199321285.001.0001

  12. Just-in time system and climate change

    Energy Technology Data Exchange (ETDEWEB)

    Caceres, J.; Richards, D.

    1999-10-01

    The recent trends in freight transportation and its relationship with production and distribution were analyzed. This was done in an effort to help policy makers develop strategies to reduce greenhouse gas emissions and to develop a freight transportation system and a route system that is environmentally, economically and socially sustainable. One of the ways to find a solution is to restructure the overall industry organization and its link to transportation and the economy. However, this method is met with a lot of resistance by policy makers. Another method would be to find a way to delay or avoid restructuring; for example, by using unlimited greenhouse gas emissions trading. By doing so, emissions reductions would be targeted where they are most economically efficient. 18 refs., 1 fig.

  13. 2599-IJBCS-Article-Arcadius Yves Justin A+

    African Journals Online (AJOL)

    hp

    (Toffo) introduite depuis 1916 (Béhaghel,. 1999) et la provenance dite tanzanienne. Cette dernière a montré de meilleures performances de croissance (Azankpan et al., 2009 ;. Kokutse et al., 2009). La provenance tanzanienne introduite dans le pays par l'Office National du Bois, entreprise publique en charge de la gestion ...

  14. Adventures from Justin's Life: Engaging Your Physics Students

    Science.gov (United States)

    Ridgley, James A.; Herron, Sherry S.

    2018-03-01

    Many teachers have had students ask the proverbial question, "When will I ever use this in my life?" In the sciences, especially physics, teachers seem to battle this torrent of indifference continually. Although many areas of our students' lives can distract them from their academic pursuits, we as teachers must be introspective in order to prevent our teaching style from becoming one of our students' potential distractions. For example, a problem source with teaching physics may be an inability to successfully pique students' interest in our lessons. According to Barrett, student engagement is critical in order for learning to occur. Student engagement is so crucially important that researchers from across the globe attempt to assist teachers in the careful construction of pedagogical "hooks" whereby they can actively engage their students. A student who is not academically engaged may find little use for what is presented and may be bored stiff during the lesson. Regardless of your theoretical perspectives on learning, constructivists to traditionalists alike have no excuse to be boring, and therefore should engage their students before presenting physics concepts.

  15. 2798-IJBCS-Article-Arcadius Yves Justin Akossou

    African Journals Online (AJOL)

    hp

    économie béninoise. La filière est confrontée cependant à un certain nombre de difficultés, notamment la méconnaissance des caractéristiques des différentes variétés par les planteurs. Cette étude est donc une contribution à la caractérisation ...

  16. Planning by Using Digital Technology in the Reconstruction of Cultural Heritage Sites - a Case Study of Qiong-Lin Settlement in Kinmen Area

    Science.gov (United States)

    Yang, W. B.; Ye, Y. N.

    2017-08-01

    ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage records through the public participation, sharing new technology platform and facilitation tools for knowledge diffusion, for instance. Nikos adopted digitized intangible cultural heritage within i-Treasures project to create a novel digital platform in 2016. Nowadays, the display platform developed based on geographic information system has been gradually accepted and widely used to distribute cultural heritage information, aiming to combine geography, time, events, issues, trends with the interactive maps to show the context of data changes from the consideration of planarity; for example, Burnaby City in Canada has cooperated with the Columbia University to create a navigation platform for guidance of tangible cultural heritage based on story maps in order to provide public recognition function. In this study, Qiong-Lin Settlement in Kinmen Area was taken as an example to illustrate the developing process of an overall planning framework for reappearing the glory of historic settlements of cultural heritage sites with digital technology, which included tangible and intangible cultural heritage preservation and transmission planning, community participation and digital navigation programs. The digital technology with the GIS-based digital platform can provide more diverse and interesting information while using an intuitive, graphical user story mapping interface. So that tangible cultural heritage can be effectively understood, interpreted and preserved with the value-added methods, and also intangible cultural heritage can be continuously transmitted to establish a complete system of cultural heritage preservation. The main contents include several navigation technologies, such as 3D laser scanning, UAV images

  17. [Pollution characteristics and ecological risk assessment of heavy metals in surface sediments of Qingshan Reservoir in Lin' an City, Zhejiang Province of East China].

    Science.gov (United States)

    Zhang, Fen; Yang, Chang-Ming; Pan, Rui-Jie

    2013-09-01

    A total of 8 representative surface sediment sampling sites were collected from the Qingshan Reservoir in Lin'an City of Zhejiang Province to investigate the differences in the total concentrations of As, Cr, Cu, Ni, Mn, Pb, and Zn among the sampling sites. The different forms of the heavy metals, i. e., acid soluble, easily reducible, easily oxidizable, and residual, were determined by BCR sequential extraction method, and the pollution degrees and potential ecological risk, of the heavy metals in the surface sediments at different sampling sites of the Reservoir were assessed by using geo-accumulation index (I(geo)) and Hakanson potential ecological risk index. There existed obvious spatial differences in the total concentrations of the heavy metals in the surface sediments of the Reservoir. The sampling sites nearby the estuaries of the tributaries flowing through downtowns and heavy industrial parks to the Reservoir had obviously higher heavy metals concentrations in surface sediments, as compared to the other sampling sites. In the sediments, Mn was mainly in acid extractable form, Cu and Pb were mainly in reducible form, and As was mainly in residual form. The surface sediments at the sampling sites nearby the estuaries of the tributaries flowing through downtowns to the Reservoir had higher proportions of acid extractable and reducibles forms of the heavy metals, which would have definite potential toxic risk to aquatic organisms. Among the 7 heavy metals in the surface sediments, As showed the highest pollution degree, followed by Cu, Ni, Mn, Pb, and Zn, which were at moderate pollution degree, while Cr was at non-pollution degree, with relatively low potential ecological risk. Through the comparison of the sampling sites, it was observed that the surface sediments at the sites nearby the estuaries of Jinxi River and Hengxi River flowing through downtowns and heavy industrial parks to the Reservoir showed obviously higher heavy metals pollution degree and

  18. Caenorhabditis elegans histone deacetylase hda-1 is required for morphogenesis of the vulva and LIN-12/Notch-mediated specification of uterine cell fates.

    Science.gov (United States)

    Ranawade, Ayush Vasant; Cumbo, Philip; Gupta, Bhagwati P

    2013-08-07

    Chromatin modification genes play crucial roles in development and disease. In Caenorhabditis elegans, the class I histone deacetylase family member hda-1, a component of the nucleosome remodeling and deacetylation complex, has been shown to control cell proliferation. We recovered hda-1 in an RNA interference screen for genes involved in the morphogenesis of the egg-laying system. We found that hda-1 mutants have abnormal vulva morphology and vulval-uterine connections (i.e., no uterine-seam cell). We characterized the vulval defects by using cell fate-specific markers and found that hda-1 is necessary for the specification of all seven vulval cell types. The analysis of the vulval-uterine connection defect revealed that hda-1 is required for the differentiation of the gonadal anchor cell (AC), which in turn induces ventral uterine granddaughters to adopt π fates, leading to the formation of the uterine-seam cell. Consistent with these results, hda-1 is expressed in the vulva and AC. A search for hda-1 target genes revealed that fos-1 (fos proto-oncogene family) acts downstream of hda-1 in vulval cells, whereas egl-43 (evi1 proto-oncogene family) and nhr-67 (tailless homolog, NHR family) mediate hda-1 function in the AC. Furthermore, we showed that AC expression of hda-1 plays a crucial role in the regulation of the lin-12/Notch ligand lag-2 to specify π cell fates. These results demonstrate the pivotal role of hda-1 in the formation of the vulva and the vulval-uterine connection. Given that hda-1 homologs are conserved across the phyla, our findings are likely to provide a better understanding of HDAC1 function in development and disease.

  19. The pedagogical value of a student-run community-based experiential learning project: The Yong Loo Lin School of Medicine Public Health Screening.

    Science.gov (United States)

    Wee, Liang En; Yeo, Wei Xin; Tay, Clifton M; Lee, Jeannette J M; Koh, Gerald C H

    2010-09-01

    We assessed the pedagogical value of a student-led community-based experiential learning project called the Public Health Screening (PHS) run by medical and nursing students of the National University of Singapore's Yong Loo Lin School of Medicine (NUS YLLSoM). We conducted a cross-sectional study using a self-administered anonymised questionnaire on medical and nursing students who participated in PHS using the Fund for the Improvement of Postsecondary Education (FIPSE) Survey Instrument. Participants also gave an overall score for their learning experience at the PHS. The participation rate was 93.1% (576/619) for medical students and 100% (37/37) for nursing students. All participants gave the PHS learning experience a high rating (median = 8 out of maximum of 10, inter-quartile range, 7 to 9). A majority of participants felt that PHS had helped them to improve across all domains surveyed. For medical students, those in preclinical years and females were independently more likely to feel that PHS had helped them to improve in communication skills, teamwork, ability to identify social issues, taking action, and gaining and applying their knowledge than those in clinical years and males. Improved ability to interact with patients (β=1.64, 95%CI, 1.01-2.27), appreciation of challenges to healthcare faced by Singaporeans from lower income groups (β=0.93, 95%CI, 0.49-1.37), thinking of others (β=0.70, 95%CI, 0.04-1.37) and tolerance of different people (β =0.63, 95%CI, 0.17-1.10) were strongly associated with the overall rating score. PHS was a positive learning experience in a wide range of domains for all students involved. This suggests that student-organised community-based experiential learning projects have potential educational value for both medical and nursing students.

  20. SKR-1, a homolog of Skp1 and a member of the SCFSEL-10 complex, regulates sex-determination and LIN-12/Notch signaling in C. elegans

    Science.gov (United States)

    Killian, Darrell J.; Harvey, Elizabeth; Johnson, Peter; Otori, Muneyoshi; Mitani, Shohei; Xue, Ding

    2008-01-01

    Sex-determination in C. elegans requires regulation of gene transcription and protein activity and stability. sel-10 encodes a WD40-repeat-containing F-box protein that likely mediates the ubiquitin-mediated degradation of important sex-determination factors. Loss of sel-10 results in a mild masculinization of hermaphrodites, whereas dominant alleles of sel-10, such as sel-10(n1074), cause a more severe masculinization, including a reversal of the life versus death decision in sex-specific neurons. To investigate about how sel-10 regulates sex-determination, we conducted a sel-10(n1074) suppressor screen and isolated a weak loss-of-function allele of skr-1, one of 21 Skp1-related genes in C. elegans. Skp1, Cullin, and F-box proteins, such as SEL-10, are components of the SCF E3 ubiquitin ligase complex. We present genetic evidence that the sel-10(n1074) masculinization phenotype is dependent upon skr-1 and cul-1 activity. Furthermore, we show that the SKR-1(M140I) weak loss-of-function mutation interferes with SKR-1/SEL-10 binding. Unexpectedly, we found that the G567E substitution in SEL-10 caused by the n1074 allele impairs the binding of SEL-10 to SKR-1 and the dimerization of SEL-10, which may be important for SEL-10 function. Our results suggest that SKR-1, CUL-1 and SEL-10 constitute an SCF E3 ligase complex that plays an important role in modulating sex-determination and LIN-12/Notch signaling in C. elegans. PMID:18718460

  1. PLANNING BY USING DIGITAL TECHNOLOGY IN THE RECONSTRUCTION OF CULTURAL HERITAGE SITES – A CASE STUDY OF QIONG-LIN SETTLEMENT IN KINMEN AREA

    Directory of Open Access Journals (Sweden)

    W. B. Yang

    2017-08-01

    Full Text Available ICOMOS Florence Declaration in 2014, encourages an in-depth reflection on human values through cultural heritage and landscapes, which emphasizes the importance of historical heritage sites, in order to achieve the application of cultural heritage records through the public participation, sharing new technology platform and facilitation tools for knowledge diffusion, for instance. Nikos adopted digitized intangible cultural heritage within i-Treasures project to create a novel digital platform in 2016. Nowadays, the display platform developed based on geographic information system has been gradually accepted and widely used to distribute cultural heritage information, aiming to combine geography, time, events, issues, trends with the interactive maps to show the context of data changes from the consideration of planarity; for example, Burnaby City in Canada has cooperated with the Columbia University to create a navigation platform for guidance of tangible cultural heritage based on story maps in order to provide public recognition function. In this study, Qiong-Lin Settlement in Kinmen Area was taken as an example to illustrate the developing process of an overall planning framework for reappearing the glory of historic settlements of cultural heritage sites with digital technology, which included tangible and intangible cultural heritage preservation and transmission planning, community participation and digital navigation programs. The digital technology with the GIS-based digital platform can provide more diverse and interesting information while using an intuitive, graphical user story mapping interface. So that tangible cultural heritage can be effectively understood, interpreted and preserved with the value-added methods, and also intangible cultural heritage can be continuously transmitted to establish a complete system of cultural heritage preservation. The main contents include several navigation technologies, such as 3D laser scanning

  2. "O Romancista e o Engenho: José Lins do Rego e o regionalismo nordestino dos anos 1920 e 1930", de Mariana Ghaguri "O Romancista e o Engenho: José Lins do Rego e o regionalismo nordestino dos anos 1920 e 1930", by Mariana Chaguri

    Directory of Open Access Journals (Sweden)

    Mário Augusto Medeiros da Silva

    2013-04-01

    Full Text Available Trata-se das relações entre a formalização estética do Ciclo da Cana de Açúcar e o processo social do Regionalismo Nordestino. Analisa a trajetória social e produção literária de José Lins do Rego, buscando deslindar as formas de realização social do autor, nos circuitos intelectuais e políticos de que participou (Pernambuco e Rio de Janeiro, notadamente e as condições sociais de produção de sua obra (editoras em que a mesma é publicada, recepção entre a crítica de época etc.. Em vista das disputas travadas com os Modernistas paulistas de 1922, sua interpenetração com a crise política dos anos 1930 e com as formulações de Gilberto Freyre acerca das ideias de Região e Nação, Chaguri sugere a análise do Regionalismo Nordestino como parte de um projeto estético e político, cujas intenções e consequências merecem ser sociologicamente examinadas.The book deals with the relations between the aesthetics formalization of the Sugarcane Cycle and the social process of the Brazilian Northeastern regionalism. It analyzes the social trajectory and literary work of José Lins do Rego, seeking to disclose this author's ways of social fulfillment in the intellectual and political circles he participated (especially in Pernambuco and Rio de Janeiro as well as the social conditions of production of his work (his publishers, critiques etc.. Considering his disputes with members of the 1922 modernist movement, intertwined with the political crisis of the 1930s and the formulations of Gilberto Freyre's notions about Region and Nation, Chaguri suggests the analysis of Northeastern Regionalism while part of an aesthetic and political project whose intentions and consequences deserve to be sociologically examined.

  3. É tempo de pipa: a representação da infância em Cidade de Deus, de Paulo Lins, e Lembrancinha do Adeus, de Júlio Ludemir

    Directory of Open Access Journals (Sweden)

    Anderson Luís Nunes da Mata

    2009-01-01

    Full Text Available Traditionally understood as an age of innocence and learning, childhood has been shown indifferent colors in the so called "slum" narratives. Thus, poor children, who live in the urban peripheral areas, are represented in fiction as a counterface for such traditional notion of childhood. Lembrancinha do Adeus, by Julio Ludemir, and Cidade de Deus, by Paulo Lins, are both novels built upon characters who maintain only remains of childhood, which indicates both a new sociability for such children and deeper social changes.

  4. Linéarité et développement d'un système technique Linearity and Development of a Technical System

    Directory of Open Access Journals (Sweden)

    Dautray R.

    2006-11-01

    Full Text Available Il est examiné comment la structurede la modélisation d'un phénomène ou d'un processus ou du fonctionnement d'un appareil joue un rôle déterminant dans le plan des expériences destinées à obtenir les connaissances nécessaires à son étude et à sa réalisation. Dans le cas d'une structure linéaire , il est montré, sur l'exemple de l'énergie nucléaire, que ces expériences peuvent être menées sur des appareils distincts, les résultats de l'une servant à déterminer les entrées de l'autre. Ce découplagepermet de mener en parallèle un très grand programme d'expériences, et donc de construire relativement rapidement ces nouvelles technologies. C'est en effet le cas de l'énergie nucléaire de fission : - Le phénomène de fission a été découvert en 1938. - La démonstration de la faisabilité physique de la réaction en chaîne a été démontrée en 1942. - Les premiers réacteurs nucléaires de puissance ont fonctionné à Hanford en 1945. - Et dès les années cinquante, des réacteurs nucléaires actionnaient des sous-marins et des prototypes de chaudières nucléaires pour centrales (Shippingport et Calder Hall. This article examines how the structureof the modeling of a phenomenon or process or the operating of a piece of equipment plays a determinant role in the planning of experiments for the purpose of obtaining the understanding required to analyze it and create it. For a linear structure , the example of nuclear energy is taken to show that these experiments can be performed with distinct pieces of equipment, with the results of one being used to determine the input for the other. This uncouplingenables a very widespread experimental project to be carried out in parallel, so that these new technologies can be built up relatively quickly. This is effectively true for nuclear energy from fission. - The phenomenon of fission was discovered in 1938. - The physical feasibility of the chain reaction was demonstrated

  5. WYSTĘPOWANIE ROŚLIN INWAZYJNYCH W OBRĘBIE BUDOWLI I POWIERZCHNI UTWARDZONYCH W DOLINACH RZECZNYCH KARPAT I KOTLINY SANDOMIERSKIEJ

    Directory of Open Access Journals (Sweden)

    Dominik WRÓBEL

    Full Text Available Badania terenowe, prowadzone w latach 2010-2016, w dolinach rzecznych polskiej części Karpat oraz w Kotlinie Sandomierskiej i w przylegającym do niej odcinku doliny Wisły, miały za zadanie uzupełnić, wiedzę o występowaniu inwazyjnych gatunków roślin (inwaderów w najsilniej przekształconych dolinach rzecznych, a w szczególności określić typy zabudowy dolin rzecznych, sprzyjające rozprzestrzenianiu się tych gatunków. Przeanalizowano 118 transektów zlokalizowanych zarówno w regionach górskich, podgórskich i nizinnych, w odcinkach uregulowanych jak i nieuregulowanych dolin rzecznych, cieków o różnej wielkości. Wyodrębniono główne typy/kategorie zabudowy, łączące w sobie: obiekty hydrotechniczne i przeciwpowodziowe, w tym obwałowania, umocnienia brzegowe i ostrogi korytowe (I, mieszkalną i usługową zabudowę śródmiejską (II, drogowe i kolejowe linie komunikacyjne, w tym mosty (III, wyrobiska górnicze, zabudowę produkcyjną, wydobywczą, magazynową i towarzyszącą (IV, zabudowę rozproszoną, ogródki działkowe (V oraz odrębne place, parkingi i składowiska (VI. Na częściach transektów, obejmujących różne formy zabudowy, najczęściej zanotowano występowanie Solidago gigantea / S. canadensis (46, Impatiens glandulifera (30, Echinocystis lobata (22, Robinia pseudoacacia (17, Helianthus tuberosus (15 i Impatiens parviflora (15. Największa liczba stanowisk gatunków inwazyjnych w relacji do wszystkich ich stwierdzeń została zanotowana na różnego rodzaju budowlach hydrotechnicznych, w tym na umocnieniach brzegowych różnego typu. Obserwacje prowadzone w zakresie wpływu inwestycji regulacyjnych na szatę roślinną wskazują, że nie ma istotnych różnic co do zastosowanych sposobów zabudowy umocnieniowej brzegów, które można byłoby uznać za bardziej przyjazne środowisku. W każdym przypadku następuje pozostawianie odkrytego podłoża i promowanie wkraczania inwaderów.

  6. Saúde mental no Sistema Único de Saúde: mudança do modelo de atenção na região de Lins-SP Mental health in Sistema Único de Saúde: changing the care model in the region of Lins - SP

    Directory of Open Access Journals (Sweden)

    Carlos Cesar Escudeiro

    2009-03-01

    Full Text Available Omunicípio de Linspassou portransformações significativas na atenção em Saúde Mental, evoluindo deum modelo de referência hospitalar para um modelo de base territorial e comunitária. Este trabalho tem como objetivo realizar uma retrospectiva históricadas mudanças ocorridas, descrevendoas ações de assistência, promoção, prevenção e reabilitação psicossocial, através da implantação deserviços substitutivos integrados à atenção básica, apontando as soluções capazes de efetivar os princípios do Sistema Único de Saúde (SUS. Priorizou-se a implantação dos Centros de atenção Psicossocial que são dispositivos estratégicos para favorecer a inserção social. A Gestão Municipal realizou significativos investimentos técnicos e financeiros que possibilitaram a consolidação da Política Nacional de Saúde Mental, ampliando as articulações intersetoriais.The municipality of Lins, in the state of São Paulo, has undergone significant transformations in Mental Health Care, evolving from a hospital reference model to a territorial and community-based model. This work aims to carry out a historical retrospective of the changes that have occurred, describing the actions of psychosocial assistance, promotion, prevention and rehabilitation through the implementation of substitutive services integrated into primary care, pointing to the solutions that can fulfill the principles of Sistema Único de Saúde (SUS - National Health System. The priority was the implementation of Centros de Atenção Psicossocial (Psychosocial Care Centers, which are strategic devices to favor social insertion. The Municipal Management has made significant technical and financial investments that have enabled the consolidation of the National Mental Health Policy, extending inter-sector articulations.

  7. Etude de la stabilité globale de l’équilibre endémique des modèles multi groupes SIR avec une incidence non linéaire.

    OpenAIRE

    BENCHAIB, NESRINE

    2014-01-01

    Dans ce mémoire, on présente le nombre de reproduction de base pour un modèle épidémique multigroupe avec une incidence non linéaire. Ensuite, on établie la dynamique globale est entièrement déterminée par le nombre de reproduction de base R0. On montre que le nombre de reproduction de base R0 est un paramètre global de seuil dans le sens que si il est inférieur ou égale à 1, l’équilibre sans maladie est globalement stable et la maladie s’éteint, alors que si il est supérieur à 1, il est u...

  8. Caractérisation microstructurale et mécanique d’un composite cimentaire renforcé par des fibres de lin Characterizations mechanical and microstructural of flax fibre cement composite reinforced

    Directory of Open Access Journals (Sweden)

    Boutouil M.

    2012-09-01

    Full Text Available Dans la perspective de valorisation des fibres de lin dans les matériaux de construction, la présente étude s’intéresse à la caractérisation microstructurale et mécanique d’un composite cimentaire renforcé par des fibres de lin. Les analyses microstructurales au MEB ont été menées pour évaluer l’homogénéité de la distribution des fibres, la qualité de l’interaction fibre/matrice et l’influence de leur présence sur les défauts microstructuraux. Le comportement mécanique en flexion du mortier renforcé par les fibres de lin est étudié en fonction de la longueur et la teneur en fibres. Les résultats indiquent une bonne adhésion entre les fibres et la matrice à l’état frais. Mais les fibres étant hydrophiles, elles gonflent pendant la prise du ciment et le retrait lors du séchage engendre alors des déchaussements. Les résultats de caractérisation mécanique sont encourageants. Tout d’abord, la fissuration du mortier due au retrait au jeune âge est fortement réduite du fait de la présence des fibres. Ensuite, la rupture brutale de la matrice en monolithe laisse place à un comportement quasi-ductile quand la teneur ou la longueur de fibre augmente. Ce changement de comportement, analysé en termes d’indice de ténacité, illustre la capacité remarquable des fibres de lin à renforcer les matrices cimentaires du fait de leurs bonnes propriétés mécaniques. With the purpose of the flax fibre valuing in construction materials, this study focuses on the characterizations mechanical and microstructural of flax fibre cement composite reinforced. The mechanical strength was studied as the function of fibre volume ratio and length. Meanwhile, the microstructural analysis investigated the homogeneity of fibre scattering, the interaction fibre/cement matrix and the influence of flax fibres on the defects microstructures. The results show the interesting mechanical properties of flax fibre in comparison with

  9. Heterodimerization with the β1 subunit directs the α2 subunit of nitric oxide-sensitive guanylyl cyclase to calcium-insensitive cell-cell contacts in HEK293 cells: Interaction with Lin7a.

    Science.gov (United States)

    Hochheiser, Julia; Haase, Tobias; Busker, Mareike; Sömmer, Anne; Kreienkamp, Hans-Jürgen; Behrends, Sönke

    2016-12-15

    Nitric oxide-sensitive guanylyl cyclase is a heterodimeric enzyme consisting of an α and a β subunit. Two different α subunits (α 1 and α 2 ) give rise to two heterodimeric enzymes α 1 /β 1 and α 2 /β 1 . Both coexist in a wide range of tissues including blood vessels and the lung, but expression of the α 2 /β 1 form is generally much lower and approaches levels similar to the α 1 /β 1 form in the brain only. In the present paper, we show that the α 2 /β 1 form interacts with Lin7a in mouse brain synaptosomes based on co-precipitation analysis. In HEK293 cells, we found that the overexpressed α 2 /β 1 form, but not the α 1 /β 1 form is directed to calcium-insensitive cell-cell contacts. The isolated PDZ binding motif of an amino-terminally truncated α 2 subunit was sufficient for cell-cell contact localization. For the full length α 2 subunit with the PDZ binding motif this was only the case in the heterodimer configuration with the β 1 subunit, but not as isolated α 2 subunit. We conclude that the PDZ binding motif of the α 2 subunit is only accessible in the heterodimer conformation of the mature nitric oxide-sensitive enzyme. Interaction with Lin7a, a small scaffold protein important for synaptic function and cell polarity, can direct this complex to nectin based cell-cell contacts via MPP3 in HEK293 cells. We conclude that heterodimerization is a prerequisite for further protein-protein interactions that direct the α 2 /β 1 form to strategic sites of the cell membrane with adjacent neighbouring cells. Drugs increasing the nitric oxide-sensitivity of this specific form may be particularly effective. Copyright © 2016 Elsevier Inc. All rights reserved.

  10. A Formalism for the Consistent Description of Non-Linear Elasticity of Anisotropic Media Formalisme pour une description cohérente de l'élasticité non linéaire des milieux anisotropes

    Directory of Open Access Journals (Sweden)

    Helbig K.

    2006-12-01

    deviation can be expressed by the relative change of the eigenstiffnesses and by the variation in the direction of the eigenstrains (expressed as vectors in six-dimensional strain space. The suggested procedure is applied to the two materials discussed by Rasolofosaon and Yin (1996. The results allow a heuristic evaluation of the meaning of the reference strain , the square root of the ratio of the norms of the fourth-rank and sixth-rank stiffness tensors. It is stressed that this is not a new theory of non-linearity, but only a different way of viewing the existing theory and results. La propagation des ondes élastiques est généralement traitée sous quatre hypothèses : - le milieu est isotrope, - le milieu est homogène, - il y a une relation biunivoque entre la tension et la déformation, - les tensions sont reliées d'une façon linéaire aux déformations (et de manière équivalente, les déformations sont reliées d'une façon linéaire aux tensions. En général au moins une de ces hypothèses - et souvent toutes - n'est pas vérifiée dans les milieux réels. Une description théorique valide de la propagation des ondes dans les milieux réels dépend ainsi de la description à la fois qualitative et quantitative de l'hétérogénéité, de l'anisotropie et de la non-linéarité : soit on doit supposer (ou montrer que l'écart par rapport à l'hypothèse de départ peut être - pour le problème considéré - négligé, soit on doit développer une description théorique, valide même en présence de ces écarts. Alors que l'effet d'un seul écart par rapport à un état idéal est relativement bien connu, les difficultés surviennent quand on veut combiner plusieurs de ces écarts. Les propriétés élastiques non linéaires d'échantillons de roche anisotropes (tricliniques ont été étudiées, par P. Rasolofosaon et H. Yin au 6e IWSA à Trondheim (Rasolofosaon et Yin, 1996. L'élasticité anisotrope non linéaire est importante seulement pour les amplitudes

  11. Étude numérique du couplage thermohydromécanique dans les roches. Influence des termes de couplage non linéaires pour un matériau isotrope linéaire Numerical Analysis of a Thermohydromechanical Coupling in Rocks. Influence of Nonlinear Coupling Terms on a Linear Isotropic Material

    Directory of Open Access Journals (Sweden)

    Henry J. P.

    2006-11-01

    Full Text Available Nous présentons dans ce travail une étude numérique basée sur la méthode des éléments finis, du comportement thermoporoélastique de certaines roches. Les trois effets de couplage : déformabilité de la roche, pression interstitielle et température sont pris en compte simultanément dans la résolution numérique. Une application simple sur un puits pétrolier en conditions axisymétriques est finalement présentée afin de dégager en particulier l'influence du terme de couplage convectif non linéaire, obtenu dans l'équation de diffusivité thermique, sur l'évolution de la température et de la pression interstitielle autour du forage. This article describes a finite-element method for solving the problem of nonlinear coupling between interstitial pressure and temperature during stress on a poroelastic rock. Such coupling phenomena occur during massive injection of cold water into a petroleum borehole for example. The implementation of such a numerical solution, used here with the assumption of small deformations, first requires a review of the behavior law of the material (Eq. 2. 2 and of the equations for hydraulic diffusivity (Eq. 2. 3 and thermal diffusivity (Eq. 2. 4. This last equation (2. 4 is the one containing the nonlinear coupling terms in Grad P Grad P and Grad T. Grad P. During simulation of flow at a high flow rate, these products can no longer be neglected as shown by the results in Fig. 2. The variational formulation of the problem is then determined in relation to the three equations for equilibrium, thermal diffusivity and hydraulic diffusivity. After geometric and temporal discretizations, this formulation leads to a finite-element calculating scheme resulting in the simultaneous solving of all three equations. This solution, based on the inversion of the system of equations (2. 15, requires the updating of the rigidity matrix at each time step to take nonlinear coupling into consideration. Calculations with an

  12. A model for the Lin-Shu type density-wave structure of our Galaxy: Line-of-sight and transverse-longitudinal velocities of 242 optically visible open clusters

    Science.gov (United States)

    Griv, E.; Jiang, I.-G.

    2015-02-01

    In this paper, the fourth in a series, we examine again one of the implications of the Lin-Shu density-wave theory, specifically, the noncircular systematic motion of the Galactic objects. Our previous investigation is extended by analyzing simultaneously both the line-of-sight and transversal velocities of a sample of open clusters for which velocities, distances and ages are available. The ordinary equations of the Oort-Lindblad theory of galactic differential rotation are used. The minor effects caused by the two-dimensional tightly-wound density waves are also taken into account. The published data of 242 currently known optically visible clusters having distances rsight and transversal along the Galactic longitude velocities are nearly equal. We argue that the resemblance of these Galactic wave structures is so remarkable that no doubt is felt as to the theory's truth with respect to these data. The results obtained allow us to conclude that several low-m trailing density-wave patterns with different number of spiral arms m (say, m=1, 2, 3, and 4), pitch angles (about 5o, 8o, 11o, and 14o, respectively) and amplitudes of the perturbed gravitational potential may coexist in the Galaxy. The latter suggests the asymmetric multiarm, not well-organized (``flocculent'') spiral structure of the system. In memory of Professors Alexei M. Fridman (1940-2010) and Chi Yuan (1937-2008)

  13. Structural properties of small Lin (n = 5-8) atomic clusters via ab initio random structure searching: A look into the role of different implementations of long-range dispersion corrections

    Science.gov (United States)

    Putungan, Darwin Barayang; Lin, Shi-Hsin

    2018-01-01

    In this work, we looked into the lowest energy structures of small lithium clusters (Lin, n = 5, 6, 7, 8) utilizing conventional PBE exchange-correlation functional, PBE with D2 dispersion correction and PBE with Tkatchenko and Scheffler (TS) dispersion correction, and searched using ab initio random structure searching. Results show that in general, dispersion-corrected PBE obtained similar lowest minima structures as those obtained via conventional PBE regardless of the type of implementation, although both D2 and TS found several high-energy isomers that conventional PBE did not arrive at, with TS in general giving more structures per energy range that could be attributed to its environment-dependent implementation. Moreover, D2 and TS dispersion corrections found a lowest energy geometry for Li8 cluster that is in agreement with the structure obtained via the typical benchmarking method diffusion Monte Carlo in a recent work. It is thus suggested that for much larger lithium clusters, utilization of dispersion correction could be of help in searching for lowest energy minima that is in close agreement with that of diffusion Monte Carlo results, but computationally inexpensive.

  14. Cartographie des linéaments géologiques en domaine aride par extraction semi-automatique à partir d’images satellitaires: Exemple à la région d’El Kseïbat (Sahara algérien

    Directory of Open Access Journals (Sweden)

    Hammad, N.

    2016-06-01

    Full Text Available Geologists in charge of a detailed lineament mapping in arid and desert area, face the extent of the land and the abundance of eolian deposits. This study presents a semi-automatic approach of extraction of lineament, different from other methods, such as the automatic extraction and manual extraction, by being both fast and objective. It consists of a series of digital processing (textural and spatial filtering, binarization by thresholding and mathematic morphology ... etc. applied to a Landsat 7 ETM+scene. This semi-automatic approach has produced a detailed map of lineaments, while taking account of tectonic directions recognized in the region. It helps mitigate the effect of dune deposits meet the specifications of arid environment. The visual validation of these linear structures, by geoscientists and field data, allowed the identification of the majority of structural lineaments or at least those tried geological.[fr] Les géologues en charge d’une cartographie des linéaments détaillée en domaine aride et désertique, font face à l’étendue des terrains et la présence abondante de dépôts éoliens. La présente étude présente une approche semi-automatique différente des autres méthodes d’extraction des linéaments, à savoir l’extraction automatique et l’extraction manuelle par le fait d’être à la fois rapide et objective. Elle consiste en une succession de traitements numériques (filtrage textural et spatial, binarisation par seuillage et morphologie mathématique…etc. appliqués sur une scène LANDSAT-7 ETM+. Cette approche semi-automatique a permis d’obtenir une carte détaillée des linéaments, tout en tenant compte des directions tectoniques reconnues dans la région. Elle permet d’atténuer l’effet des dépôts dunaires répondant aux spécifications du contexte aride. La validation visuelle de ces structures linéaires, effectuée sur terrain et sur la base de la carte géologique et des données g

  15. Alimentation animale et organisation des filières : une comparaison pois protéagineux-lin oléagineux pour comprendre les facteurs freinant ou favorisant les cultures de diversification

    Directory of Open Access Journals (Sweden)

    Charrier François

    2013-07-01

    Full Text Available Le processus d’intensification des élevages, entamé dans les années 1970, s’est accompagné d’un développement croissant du recours aux aliments dits « composés », fabriqués à partir de différentes matières premières pour la plupart d’origine végétale. Les pratiques de la formulation des fabricants d’aliments composés, fondées sur une très forte substituabilité des matières premières, génèrent une concurrence très forte entre ces commodités. Dans un tel contexte de marché, la valorisation de certaines espèces repose sur des mécanismes permettant de contourner ou de s’affranchir de cette concurrence, mais dont l’efficacité reste fortement dépendante de l’organisation des acteurs au sein des filières. À partir de la comparaison des filières pois et lin, nous montrons ainsi qu’au-delà de la reconnaissance de propriétés nutritionnelles spécifiques pouvant valoriser différemment certaines espèces, la coordination des acteurs le long d’une filière est déterminante dans la diffusion des incitations économiques et informationnelles nécessaires à une orientation des agriculteurs en faveur d’espèces de diversification d’intérêt agro-écologique.

  16. Radiosensitivity study in rice (Oriza Sativa Lin.)

    International Nuclear Information System (INIS)

    Gonzalez, M.; Santana, N.; Diaz, R.

    1987-01-01

    Four rice varieties (J-104, Amistad-82, 6066 and IR-1529) were irradiated at doses of 10,15,20,25,30,35,40,45,50 and 55 Krad of gamma rays so as to determine radiosensitivity curves for each of the varieties for the following factors; seed germination percentage; survival percentage; height of the plant; length of roots. It was determined that IR-1529 variety is the one with the highest sensitivity and that radiations over 35 Krad should not be used for none of the varieties above mentioned

  17. Comportement mécanique des tuyaux. Influence de la traction, de la pression et du poids linéique. Application aux risers Mechanical Behavior of Pipes and Risers. Influence of Tension, Pressure and Weight

    Directory of Open Access Journals (Sweden)

    Sparks C.

    2006-11-01

    Full Text Available L'influence de la traction, de la pression et du poids linéique sur le comportement d'un tuyau (ou d'un riser a déjà été traitée dans de nombreux articles. Malgré cela, elle est fréquemment mal comprise, ce qui a parfois de; conséquences sérieuses. Par souci de clarté, l'approche de cet article est délibérément très élémentaire. Les problèmes principaux de la flexion, du flambage, de l'allongement et de la contrainte limite, qui sont souvent traités dans des articles différents, sont ici étudiés ensemble d'une façon homogène. On présente des interprétation: physiques, faciles à visualiser, des deux concepts de tension effective et de contrainte effective, dont l'utilisation est très répandue, ainsi que leur rapport avec des notions analogues dans d'autres domaines de l'art de l'ingénieur. La puissance de ces deux concepts est démontrée à la fin de l'article où ils sont utilisés pour résoudre huit problèmes divers. The influence of tension, pressure, and weight on different aspects of pipe and riser behavior has already been the subject of many articles (see references. In spite of this it has frequently been misunderstood, sometimes with serious consequences. The object of this payer is to explain the subject clearly and the approach is therefore deliberately very elementary. The principal problems of bending, buckling, yielding and strains, usually treated in separated papers, are here treated homogeneously. The widely used concepts of effective tension and effective stress are given interpretations, easy to visualise, which are related to analogous concepts in other engineering fields. Finally, eight diverse particular examples of the influence of tension, pressure and weight on pipe and riser behavior, are discussed.

  18. A Real-Time Implementable NMPC Output Feedback for a Diesel Engine Air Path Commande prédictive non linéaire avec retour de sortie implémentable en temps-réel pour un circuit d’air d’un moteur Diesel

    Directory of Open Access Journals (Sweden)

    Murilo A.

    2011-09-01

    Full Text Available In this paper, an experimental validation of a parameterized Nonlinear Model Predictive Control (NMPC scheme with a Moving Horizon Observer (MHO is presented for a Diesel engine air path. The control design based on the parameterized approach leads to a low dimensional optimization problem which makes the proposed controller real-time implementable. An attractive feature of this control strategy lies in its compatibility with more elaborated and fully nonlinear models since it uses the model as a black box predictor. Dans cet article, une validation expérimentale d’un schéma de commande prédictive non linéaire (CPNL paramétrique avec un observateur à horizon glissant a été proposé pour le circuit d’air d’un moteur Diesel. La stratégie de commande basée sur l’approche paramétrique à faible dimension s’est montrée implémentable en temps réel et peut être utilisée aussi en tant qu’une solution du type boîte noire indépendamment de la structure du modèle non linéaire.

  19. Across the Baltic : a Mission to Raise Awareness of Communist Crimes / Justin Petrone

    Index Scriptorium Estoniae

    Petrone, Justin, 1979-

    2008-01-01

    Paar aastat tagasi loodi Rootsis mittetulundusühing Organization for Information on Communism (UOK), et Rootsi noortele selgitada kommunismi olemust, selle mõju regiooni ja naaberriikide ajaloole, arengule ning tänapäevale. Organisatsiooni auliikmeteks on ka Carl Bildt ja Mart Laar

  20. Adventures from Justin's Life: Engaging Your Physics Students

    Science.gov (United States)

    Ridgley, James A., Jr.; Herron, Sherry S.

    2018-01-01

    Many teachers have had students ask the proverbial question, "When will I ever use this in my life?" In the sciences, especially physics, teachers seem to battle this torrent of indifference continually. Although many areas of our students' lives can distract them from their academic pursuits, we as teachers must be introspective in…

  1. One-step hysteroscopic myomectomy using Lin dissecting loop and Lin myoma graspers

    Directory of Open Access Journals (Sweden)

    Bao-Liang Lin

    2012-11-01

    Conclusion: Using our technique and instruments, it is possible to remove a myoma in a single procedure safely and effectively. This surgical method can also preserve more endometrium, cause less injury to the muscle layer, and prevent fluid complications.

  2. Ancrage des vortex dans les supraconducteurs Description phénoménologique de la réponse linéaire d'un de vortex ancré

    Science.gov (United States)

    Lütke-Entrup, N.; Plaçais, B.; Mathieu, P.; Simon, Y.

    Vortices pinning in supraconductors In this article we report on the investigation of the dynamics of vortices based on the high frequency linear response. We present a serie of measurements of the complex penetration depth in the mixed state in a variety of samples, including conventional materials (Nb, V, PbIn), the non-conventional heavy fermion UPt3, and the high-T_c cuprate YBaCuO. We have explored a large frequency range (1 kHz 10 MHz) so as to cover the cross-over from the quasi-static response, which is dominated by elastic interactions between vortices and sample defects, to the high-frequency regime, which is governed by viscous damping due to vortex friction against the host crystal. For a quantitative description of the frequency spectrum we start from a phenomenological theory which makes a rigorous distinction between vortex lines, along a vortex field omega, and magnetic field lines B. It predicts a second electrodynamical mode, which is linked to the vortex line tension and has a rather short range. We show that, in the limit of small vortex oscillations, amplitude and phase of the linear response are governed by an additional boundary condition for the vortex lattice at the sample surface ; it takes the form of a slipping condition with a characteristic length that depends on the surface roughness. The frequency spectrum deduced from this mechanism is clearly different from the Campbell spectrum, which is the common signature of all bulk pinning mechanisms. Our results on samples of PbIn, Nb, V, and YBaCuO entirely confirm our model, including some non-intuitive size effects which appear at low frequency when the sample becomes transparent to the flux flow mode. However, our measurements in the B and C phases of UPt3 reveal and important contribution of the bulk to the vortex pinning. Ce travail porte sur l'étude de l'ancrage des vortex par la réponse linéaire haute fréquence. Nous présentons une série de mesures de la profondeur de p

  3. Nonlinear EGR and VGT Control with Integral Action for Diesel Engines Régulation de Recirculation des Gaz d’Echappement (RGE et de Turbine à Géométrie Variable (TGV non linéaire avec action intégrée pour moteurs Diesel

    Directory of Open Access Journals (Sweden)

    Wahlström J.

    2011-10-01

    Full Text Available A nonlinear multivariable control design with integral action is proposed and investigated for control of Exhaust Gas Recirculation (EGR and Variable Geometry Turbine (VGT in heavy duty Diesel engines. The main control goal is to regulate oxygen/fuel ratio and intake manifold EGR-fraction, and they are specified in an outer loop. These are chosen as main performance variables since they are strongly coupled to the emissions. An existing nonlinear control design based on feedback linearization is extended with integral action. In particular, the control design method utilizes a control Lyapunov function, inverse optimal control, and a nonlinear input transformation. Comparisons between different control structures are performed in simulations showing the following four points. Firstly, integral action is necessary to handle model errors so that the controller can track the performance variables specified in the outer loop. Secondly, the proposed control design handles the nonlinear effects in the Diesel engine that results in less control errors compared to a control structure with PID controllers. Thirdly, it is important to use the input transformation and it is sufficient to use a control structure with PID controllers and input transformation to handle the nonlinear effects. Fourthly, the proposed control design is sensitive to model errors in the input transformation while a control structure with PID controllers and input transformation handles these model errors. Une conception de régulation non linéaire à variables multiples avec action intégrée est proposée et étudiée pour une régulation de la Recirculation des Gaz d’Echappement (RGE et une Turbine à Géométrie Variable (TGV au sein de moteurs Diesel à usage industriel. L’objectif principal de la régulation consiste à réguler le rapport oxygène / carburant et la fraction de RGE de tubulure d’admission, qui sont spécifiés au sein d’une boucle extérieure. Ceux

  4. Méthode intégro-variationnelle appliquée aux probèmes intérieur et extérieur avec surface libre de l'hydrodynamique linéaire Integro-Variational Method Applied to Indoor and Outdoor Problems with a Free Surface of Linear Hydrodinamics

    Directory of Open Access Journals (Sweden)

    Berhault C.

    2006-11-01

    Full Text Available Le but de cet article est de montrer que l'on peut appliquer une rintégro-variationnelle pour résoudre les problèmes intérieur (comportementliquide en milieu confiné et extérieur (diffraction-radiation de l'hydrodynamique linéaire. Une comparaison des résultats obtenus pour le problème intérieur dans Q les méthodes classiques : équation intégrale (singularités et formulation rationnelle (éléments finis, montre les avantages de cette méthode. The aim of this article is to show that an integro-variational method can be applied for solving interior (behavior of a liquid in a confined environment and exterior (diffraction-radiation problems of linear hydrodynamics. A comparison of the results obtained for the interior problem in IR2 with conventional methods, i.e. intégral équation (singularities and variational formulation (finite elements, shows the advantages of this method.

  5. A Fully Analytical Solution of the Wellbore Stability Problem under Undrained Conditions Using a Linearised Cam-Clay Model Solution analytique au problème de stabilité de puits en conditions non drainées utilisant un modèle de Cam-Clay linéarisé

    Directory of Open Access Journals (Sweden)

    Charlez P. A.

    2006-12-01

    Full Text Available This paper presents a linearised version of the Cam-Clay model fully integrated in the scope of the general theory of poroplasticity. The constitutive law which is developed in the scope of the effective plastic stress concept, only contains two plastic parameters (hardening modulus and slope of the critical state line. To be validated, the model is integrated over homogeneous stress paths (hydrostatic, drained triaxial and undrained triaxal then compared with experimental data issued from conventional laboratory triaxial tests. In the second part, a simplified version of the model is applied to the wellbore boundary problem (vertical well in an axisymmetric horizontal stress field and under undrained conditions. Given the linearity of the constitutive law and the a priori knowledge of the shape of the plastic region, the solution (stress, strain and pore pressure is fully analytical. The solution shows that for an overconsolidated material (overconsolidation degree less than 2 the hoop stress is strongly relaxed in the plastic zone. The higher the compressibility of the saturating fluid, the larger the relaxation of the hoop stress. In terms of stability, the more compressible the fluid saturating the porous medium is, the more stable the well will be. Finally the larger the overconsolidation ratio is, the less stable the well will be. Cet article présente une version linéarisée du modèle de Cam-Clay intégré dans le cadre général de la théorie de la poroplasticité isotherme. La loi de comportement développée à partir du concept des contraintes effectives plastiques ne contient que deux paramètres plastiques (module d'écrouissage et pente de la droite critique. Le modèle est validé sur des chemins de contrainte homogènes (hydrostatique, triaxial drainé et triaxial non drainé et comparé à des essais expérimentaux obtenus à partir d'essais conventionnels de laboratoire. Ensuite, une version simplifiée du modèle est

  6. Identification and isolation from either adult human bone marrow or G-CSF-mobilized peripheral blood of CD34(+)/CD133(+)/CXCR4(+)/ Lin(-)CD45(-) cells, featuring morphological, molecular, and phenotypic characteristics of very small embryonic-like (VSEL) stem cells.

    Science.gov (United States)

    Sovalat, Hanna; Scrofani, Maurice; Eidenschenk, Antoinette; Pasquet, Stéphanie; Rimelen, Valérie; Hénon, Philippe

    2011-04-01

    Recently, we demonstrated that normal human bone marrow (hBM)-derived CD34(+) cells, released into the peripheral blood after granulocyte colony-stimulating factor mobilization, contain cell subpopulations committed along endothelial and cardiac differentiation pathways. These subpopulations could play a key role in the regeneration of post-ischemic myocardial lesion after their direct intracardiac delivery. We hypothesized that these relevant cells might be issued from very small embryonic-like stem cells deposited in the BM during ontogenesis and reside lifelong in the adult BM, and that they could be mobilized into peripheral blood by granulocyte colony-stimulating factor. Samples of normal hBM and leukapheresis products harvested from cancer patients after granulocyte colony-stimulating factor mobilization were analyzed and sorted by multiparameter flow cytometry strategy. Immunofluorescence and reverse transcription quantitative polymerase chain reaction assays were performed to analyze the expression of typical pluripotent stem cells markers. A population of CD34(+)/CD133(+)/CXCR4(+)/Lin(-) CD45(-) immature cells was first isolated from the hBM or from leukapheresis products. Among this population, very small (2-5 μm) cells expressing Oct-4, Nanog, and stage-specific embryonic antigen-4 at protein and messenger RNA levels were identified. Our study supports the hypothesis that very small embryonic-like stem cells constitute a "mobile" pool of primitive/pluripotent stem cells that could be released from the BM into the peripheral blood under the influence of various physiological or pathological stimuli. In order to fully support that hBM- and leukapheresis product-derived very small embryonic-like stem cells are actually pluripotent, we are currently testing their ability to differentiate in vitro into cells from all three germ layers. Copyright © 2011 ISEH - Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.

  7. CSR kui äristrateegia osa / Tuuliki Kasonen-Lins

    Index Scriptorium Estoniae

    Kasonen-Lins, Tuuliki

    2008-01-01

    Autor selgitab, et ettevõtte ühiskondlik vastutus ei ole kord aastas korraldatav heategevuskampaania. Näitena ettevõtte ühiskondlikust vastutusest nimetab autor panustamist tööjõu koolitusse või töötute sotsiaalsete gruppidega tegelemisse

  8. Fair trade - Õiglane kaubandus / Tuuliki Kasonen-Lins

    Index Scriptorium Estoniae

    Kasonen-Lins, Tuuliki

    2007-01-01

    Õiglase kaubanduse liikumise ajaloolisest arengust. Fair trade on kaubandusvõrk, kus kaubeldakse arengumaades inimväärsetes tingimustes toodetud ja sealsetelt kaupmeestelt õiglaste hindadega ostetud kaupadega. Fair Trade Euroopas

  9. Developmental Test of the Honeywell Laser Inertial Navigation System (LINS)

    Science.gov (United States)

    1975-11-01

    The ISA contains three Systron Donner 4841F-10 single axis accelerometers and three Honeywell GG1300- AEOI laser gyros in an orthogonal strapdown...DIAG.1,kM AN.D PHYSICAL CHARACTERISTICS The GG1300- AEOI laser gyro, shown schematically in Figure 2, has the following performance goals which were

  10. Allelopathic effect of Jatropha curcas (Lin) leachate on germination ...

    African Journals Online (AJOL)

    Laboratory study was conducted using sterilized petri dishes with double layer of Whatman filter paper at averagely 27oC and 70% humidity. An interval of 24, 48, 76 and 92 hours were recorded on germination studies while radicle and shoot lengths at 92nhours respectively. Decreased in germination percentage, shoot ...

  11. 75 FR 842 - Action Affecting Export Privileges: Hailin Lin

    Science.gov (United States)

    2010-01-06

    ... People's Republic of China (PRC) in violation of U.S. export control laws by failing to obtain the proper... (50 U.S.C. 1701-1706). Charge 1: 15 CFR 764.2(d)--Conspiracy To Export Electronic Components to the... was done so that Shipper's Export Declarations, which are filed with the U.S. Government and which...

  12. Effects of potassium behaviour in soils on crop absorption | Lin ...

    African Journals Online (AJOL)

    Potassium (K) is one of the three major elements that play important roles in plants, such as maintaining turgor of cells, promoting activation of enzymes, and improving efficiency of photosynthesis. The types of K in soil may affect the plant absorption of K. K in soils includes K minerals, K in layered silicates (clay minerals), ...

  13. Tabish Khair, Martin Leer, Justin Edwards & Hanna Ziadeh, eds. Other Routes - 1500 Years of African and Asian Travel Writing

    Directory of Open Access Journals (Sweden)

    Florence D’SOUZA

    2006-10-01

    Full Text Available This anthology of extracts from non-European travel texts, by Asians and Africans, in English translation, spans from the 5th century AD to the 19th century AD. It is edited by four contemporary scholars, one of Indian origin, two Danish, and one of Egyptian origin, all attached to Danish academic institutions. Six other contemporary scholars from a variety of countries have also contributed extracts and introductory presentations among the book's thirty-three sections, that include the writi...

  14. Gathering Leaves & Lifting Words. Histories of Buddhist Monastic Education in Laos and Thailand, Justin Thomas McDaniel

    Directory of Open Access Journals (Sweden)

    Guillaume Rozenberg

    2012-09-01

    Full Text Available Depuis maintenant trois ou quatre décennies, on a vu la constitution aux États-Unis, du moins pour ce qui concerne les recherches sur les sociétés theravādin d’Asie du Sud et du Sud-Est, d’une sorte d’école qu’on qualifierait volontiers de « bouddhographique », mélange détonnant de bouddhologie et d’ethnographie. Ses représentants se distinguent par la conjonction d’une solide culture classique (maîtrise du pâli et souvent du sanskrit, une formation pluridisciplinaire à la croisée de la phil...

  15. Yi lin cuo yao(Essentials of Medical Works) and its historical materials of medical exchanges between China and Korea%朝鲜《医林撮要》所载中朝医学交流史料研究

    Institute of Scientific and Technical Information of China (English)

    梁永宣

    2001-01-01

    由朝鲜内医郑正先撰、杨礼寿校正,成书于16~17世纪时期的《医林撮要》一书,共13卷128门,它引用了大量李朝前期的朝鲜医书及当时已成书的中国医书资料,是一部非常切合临床应用的综合性方书。特别是书中所收载的“中朝质问方”和“中朝传习方”中的方剂,若干处与中国宋代医书《仁斋直指方论》等有诸多联系,是中国和朝鲜医学交流过程中的重要记录。但它与记载中朝两国政府官员之间医学质问的傅懋光《医学疑问》毫不相关。%Yi lin cuo yao,including 13 chapters and 128 categories,was written by Zheng Zhengxian and collated by Yang Lishou,both Korean imperial physicians in the 16-17th centuries.With notation of a number of the Chinese and Korean medical books and materials in the first decade of the Li dynasty,this book is a comprehensive prescription work,very useful to clinical application.Especially with several points of the formulas from Zhong chao zhi wen fang (Sino-Korean Prescriptions of Questioning) and zhong chao chuan xi fang (Sino-Korean Prescriptions of Questioning) recorded in this book connected with Ren zhai zhi zhi fang lun (Renzhai's Comprehensive Prescriptions) in the Song dynasty.This book is an important record of the exchanges on medical ideas between China and Korea.However,it has nothing to do with Yi xue yi wen (Questions on Medicine) by Fu Maoguang,which records the questions and answers between Chinese and Korean officials.

  16. The Effects of Cassady and Justin's Functional Model for Emotional Information Processing on Improving Social Competence of First Grade Children with ADHD

    Science.gov (United States)

    Eissa, Mourad Ali

    2017-01-01

    This study explores whether or not Emotional Information Processing (EIP) model Intervention has positive effects on the Social Competency in first grade children with ADHD. 10 first graders primary who had been identified as having ADHD using Attention-Deficit Hyperactivity Disorder Test (ADHDT) (Jeong, 2005) and were experiencing social problems…

  17. ‘Justin Bieber Sounds Girlie’: Young People’s Celebrity Talk and Contemporary Masculinities

    OpenAIRE

    Kim Allen; Laura Harvey; Heather Mendick

    2015-01-01

    In this article, we explore the ways that contemporary young masculinities are performed and regulated through young people’s relationship with celebrity. We address the relative paucity of work on young men’s engagements with popular culture. Drawing on qualitative data from group interviews with 148 young people (aged 14-17) in England, we identify ‘celebrity talk’ as a site in which gender identities are governed, negotiated and resisted. Specifically we argue that celebrity as a s...

  18. EFFECTS OF COOPERATIVE LEARNING MODEL TYPE STAD JUST-IN TIME BASED ON THE RESULTS OF LEARNING TEACHING PHYSICS COURSE IN PHYSICS SCHOOL IN PHYSICS PROGRAM FACULTY UNIMED

    Directory of Open Access Journals (Sweden)

    Teguh Febri Sudarma

    2013-06-01

    Full Text Available Research was aimed to determine: (1 Students’ learning outcomes that was taught with just in time teaching based STAD cooperative learning method and STAD cooperative learning method (2 Students’ outcomes on Physics subject that had high learning activity compared with low learning activity. The research sample was random by raffling four classes to get two classes. The first class taught with just in time teaching based STAD cooperative learning method, while the second class was taught with STAD cooperative learning method. The instrument used was conceptual understanding that had been validated with 7 essay questions. The average gain values of students learning results with just in time teaching based STAD cooperative learning method 0,47 higher than average gain values of students learning results with STAD cooperative learning method. The high learning activity and low learning activity gave different learning results. In this case the average gain values of students learning results with just in time teaching based STAD cooperative learning method 0,48 higher than average gain values of students learning results with STAD cooperative learning method. There was interaction between learning model and learning activity to the physics learning result test in students

  19. La structure linéaire de la matrice lexico-syntaxique du roman policier

    Directory of Open Access Journals (Sweden)

    Alicja Hajok

    2017-12-01

    Full Text Available The purpose of this article is to analyse the lexical and syntactic structures typical of crime novels. The conducted research will make it possible to distinguish the lexical and syntactic matrix of the genre, with the aim of checking whether the linear order of the matrix-creating elements is aleatory or stable. The study focuses on two dimensions: semantic and lexico-syntactic.

  20. Recension af Lin Prøitz Selvbilde: Fra selvportet til #selfie

    DEFF Research Database (Denmark)

    Fausing, Bent

    2017-01-01

    Anmeldelse af katalog til udstilling om selfies i Oslo i 2016-2017. Anmeldelsen er koncentreret omkring tilgangen til selfies, som via koncentrationen om litteratur efter 2015 og omkring narcissisme forfejler sit mål og reducerer selfiens betydningsområder....

  1. General k-opt submoves for the Lin-Kernighan TSP heuristic

    DEFF Research Database (Denmark)

    Helsgaun, Keld

    2009-01-01

    Local search with k-exchange neighborhoods, k-opt, is the most widely used heuristic method for the traveling salesman problem (TSP). This paper presents an effective implementation of k-opt in LKH-2, a variant of the Lin–Kernighan TSP heuristic. The effectiveness of the implementation...

  2. National Waterway Network (line), Geographic WGS84, BTS (2006) [usace_nav_waterway_lin_BTS_2006

    Data.gov (United States)

    Louisiana Geographic Information Center — The National Waterway Network is a comprehensive network database of the nation's navigable waterways. The data set covers the 48 contiguous states plus the District...

  3. Cobordism Obstructions to Vector Fields and a Generalization of Lin's Theorem

    DEFF Research Database (Denmark)

    Svane, Anne Marie

    Atiyah and Dupont have studied the existence of linearly independent vector fields on manifolds by means of K-theory. They obtained the complete conditions for up to three independent vector fields. In the thesis, we try to copy their approach using certain spectra related to cobordism theory. We...

  4. Pediatrik obezite ve insülin direncine beslenme tedavisi yaklaşımı

    OpenAIRE

    ÖZÇELİK ERSÜ, Dilek; KIZILTAN, Gül

    2015-01-01

    Nowadays, obesity has became a major public health problem that is threatening this century. The incidence of obesity is increasing in population of all ages. It is a serious disease which is seen with disease charactized by chronic comorboid and takes effect on not only adults but also children and adolescents. This is a global problem also has affects especially at urban areas of the low- and middle-income countries. Those who used to be overweight or obese in their childhood are likely to ...

  5. Improving characteristics of goat milk yogurt drink fortified by mangosteen rind (Garcinia mangostana Lin.) extract

    Science.gov (United States)

    Wibawanti, J. M. W.; Rinawidiastuti; Arifin, H. D.; Zulfanita

    2018-01-01

    Peranakan Etawah (PE) milk is highly nutritive goaty flavour make it not preferable by consumer. Processing of yogurt drink made PE goat milk enhances palatability. Goat yogurt drink can be supplemented high antioxidantive activity by mangosteen rind extract. Comletely Randomized Design (CRD) was throughout the research with different concentrations of mangosteen rind extract (0, 1, 2, 3, and 4% (v/v). The organoleptic analysis showed the significant enhancement by fortification with mangosteen rind extract. The highest antioxidant activity was shown on the yogurt drink 4% v/v of mangosteen extract. In conclusion, the fortification of mangosteen rind extract was enhanced of characteristics of yogurt drink.

  6. Field lin topology in the dayside cusp region inferred from low altitude particle observations

    International Nuclear Information System (INIS)

    Soeraas, F.

    1977-12-01

    Dayside low altitude satellite observations of the pitch angle and energy distribution of electrons and protons in the energy range 1 keV to 100 keV during quiet geomagnetic conditions reveal that at times there is a clear latitudinal separation between the precipitating low energy (keV) electrons and protons, with the protons precipitating poleward of the electrons. The high energy (100keV) proton precipitation overlaps both the low energy electron and proton precipitation. These observations are consistent with a model where magnetosheath particles stream in along the cusp field lines and are at the same time convected poleward by an electric field. Electrons with energies of a few keV move fast and give the ''ionospheric footprint'' of the distant cusp. The protons are partly convected poleward of the cusp and into the polar cap. Here the mirroring protons populate the plasma mantle. Equatorward of the cusp the pitch angle distribution of both electrons and protons with energies above a few keV have a pancake shaped distribution indicating closed geomagnetic field lines. The 1 keV electrons penetrate into this region of closed field line structure maintaining an isotropic pitch angle distribution. The intensity is, however, reduced with respect to what it was in the cusp region. It is suggested that these electrons, the lowest measured on the satellite, are associated with the entry layer.(Auth.)

  7. Lin-Na and Yong-Xiu Afr J Tradit Complement Altern Med. (2014) 11 ...

    African Journals Online (AJOL)

    cadewumi

    Evaluation of anti-athletic fatigue activity of Schizandra chinensis aqueous extracts in mice. Afr J Pharm Pharmacol 3: 593-597. 4. Cao, Y., Hu, Y., Liu, P., Zhao, H.X., Zhou, X.J., and Wei, Y.M. (2012). Effects of a Chinese traditional formula Kai Xin San (KXS) on chronic fatigue syndrome mice induced by forced wheel running ...

  8. Commande non linéaire du moteur synchrone à aimants ...

    African Journals Online (AJOL)

    un entrainement d'une charge mécanique à deux masses. Afin d'assurer la stabilité ... robustness of the proposed control strategy and the efficiency of nonlinear controllers operating with ..... Fuzzy Logic in Solar-Wind Hybrid Power. System ...

  9. Differences in crystallization of two LinB variants from Sphingobium japonicum UT26

    Czech Academy of Sciences Publication Activity Database

    Degtjarik, O.; Chaloupková, R.; Řezáčová, Pavlína; Kutý, M.; Damborský, J.; Smatanová, I.K.

    2013-01-01

    Roč. 69, č. 3 (2013), s. 284-287 ISSN 1744-3091 Institutional support: RVO:68378050 Keywords : protein crystallization * dehalogenase Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.568, year: 2013

  10. Effect of soil moisture management on the quality of wax apple | Lin ...

    African Journals Online (AJOL)

    Wax apple (Syzygium samarngense Merr.et Perry) was one of the economically planted fruits in Taiwan. This research was conducted to evaluate the effects of different soil moisture management on increasing wax apple quality. It was preceded at two different soil properties (shallow soil and alluvial soil) in Pingtung, ...

  11. Solving Arc Routing Problems Using the Lin-Kernighan-Helsgaun Algorithm

    DEFF Research Database (Denmark)

    Helsgaun, Keld

    It is well known that many arc routing problems can be transformed into the Equality Generalized Traveling Salesman Problem (E-GTSP), which in turn can be transformed into a standard Asymmetric Traveling Salesman Problem (TSP). This opens up the possibility of solving arc routing problems using...

  12. Plant regeneration through somatic embryogenesis in three ethiopian Coffea arabica Lin. hybrids

    Directory of Open Access Journals (Sweden)

    RA Ramos

    2009-01-01

    Abbreviations: BA (6-benzyladenine; 2,4-D (2,4-dichlorophenoxyacetic acid; IBA (indole-3-butyric acid; MS (Murashige and Skoog; NAA (naphthaleneacetic acid, GA3 (Gibberellic acid, CV (Coefficient of variation, S.E (Standard error.

  13. BEG IN SE LSVANBYBE LV ERTA LIN G * „Vertaal beteken twee ...

    African Journals Online (AJOL)

    Test

    RoSENZWEtG, wat tesame met MARTIN BuBER 'n uiters merkwaardige. *Lesing gehou ... Dit het ook LuTHER, die Bybelvertaler vir die Duitse volk, wel goed ...... king en die kleur van die oorspronklike behou word selfs al sou daar mee aan ...

  14. La Physique du Futur Collisionneur Linéaire e+e- Partie I

    CERN Multimedia

    CERN. Geneva

    2004-01-01

    Depuis la fin des années 80, une grande partie de notre communauté scientifique penche pour un collisionneur électron-positon avec une énergie dans le centre de masse pouvant aller jusqu'à 500 GeV et même 1 TeV. Les technologies possibles et le programme de Physique aux différentes énergies seront détaillés, avec un accent sur les points forts (mesures de précision, secteur de Higgs) et les faiblesses de cet outil.

  15. The sup 8 Li(n,. gamma. ) sup 9 Li reaction and primordial nucleosynthesis

    Energy Technology Data Exchange (ETDEWEB)

    Mao, Z Q; Champagne, A E [Princeton Univ., NJ (USA). Dept. of Physics

    1991-01-01

    Shell-model calculations, using both p-shell and spd-shell interactions, have been used to predict the spectroscopic properties of low-lying states in {sup 9}Li. From this information, we have obtained new estimates for the rate of the {sup 8}Li(n,{gamma}){sup 9}Li reaction, which may act to limit the production of heavy elements during an inhomogeneous big bang. The two calculations produce reaction rates which differ by about a factor of 2 at the temperatures of interest, demonstrating the uncertainties in this approach. However, the spd calculation appears to be the more reliable of the two. (orig.).

  16. 'Pays' -'Land'-'Yuan Lin'. The power of landscape (architecture) terms

    NARCIS (Netherlands)

    Bruns, D.; Brink, van den A.

    2012-01-01

    In order to continue building a common body of knowledge, landscape architecture researchers and practitioners must refer to the same fundamental concepts – particularly in those instances where different words are used to describe them. This paper puts the focus on ‘landscape’, probably the most

  17. 78 Rôle hydrogéologique des linéaments structuraux en milieu ...

    African Journals Online (AJOL)

    TEDDY

    Recherche des Sciences de la Terre et des Ressources Minières, (UFR- STRM) Université ... géométriques des blocs et des débits des forages a permis de mettre en évidence le rôle hydrogéologique .... d'altitude moyenne égale à 200 m et inclinée vers la mer au sud avec une pente moyenne autour de 2 %. Le.

  18. 77 FR 18862 - Zhiwei Lin, M.D.; Decision and Order

    Science.gov (United States)

    2012-03-28

    ... authority to dispense controlled substances in California, the State in which he practices medicine and... that his ``request to set aside [the] previous ruling is without legal authority.'' Id. at 3. The ALJ... practices medicine and holds his DEA registration, and thus he no longer meets an essential condition for...

  19. Gold nanoparticles enlighten the future of cancer theranostics

    Directory of Open Access Journals (Sweden)

    Guo J

    2017-08-01

    Full Text Available Jianfeng Guo,1 Kamil Rahme,2–4 Yan He,1 Lin-Lin Li,5 Justin D Holmes,3,4 Caitriona M O’Driscoll6 1School of Pharmaceutical Sciences, Jilin University, Changchun, China; 2Department of Sciences, Faculty of Natural and Applied Science, Notre Dame University (Louaize, Zouk Mosbeh, Lebanon; 3Department of Chemistry, Tyndall National Institute, University College Cork, Cork, 4AMBER@CRANN, Trinity College Dublin, Dublin, Ireland; 5The First Hospital of Jilin University, Changchun, China; 6Pharmacodelivery Group, School of Pharmacy, University College Cork, Cork, Ireland Abstract: Development of multifunctional nanomaterials, one of the most interesting and advanced research areas in the field of nanotechnology, is anticipated to revolutionize cancer diagnosis and treatment. Gold nanoparticles (AuNPs are now being widely utilized in bioimaging and phototherapy due to their tunable and highly sensitive optical and electronic properties (the surface plasmon resonance. As a new concept, termed “theranostics,” multifunctional AuNPs may contain diagnostic and therapeutic functions that can be integrated into one system, thereby simultaneously facilitating diagnosis and therapy and monitoring therapeutic responses. In this review, the important properties of AuNPs relevant to diagnostic and phototherapeutic applications such as structure, shape, optics, and surface chemistry are described. Barriers for translational development of theranostic AuNPs and recent advances in the application of AuNPs for cancer diagnosis, photothermal, and photodynamic therapy are discussed. Keywords: multifunctional gold nanoparticles, cancer bioimaging, cancer photothermal and photodynamic therapy

  20. From lin-Benzoguanines to lin-Benzohypoxanthines as Ligands for Zymomonas mobilis tRNA-Guanine Transglycosylase: Replacement of Protein-Ligand Hydrogen Bonding by Importing Water Clusters.

    NARCIS (Netherlands)

    Barandun, L.J.; Immekus, F.; Kohler, P.C.; Tonazzi, S.; Wagner, B.; Wendelspiess, S.; Ritschel, T.; Heine, A.; Kansy, M.; Klebe, G.; Diederich, F.

    2012-01-01

    The foodborne illness shigellosis is caused by Shigella bacteria that secrete the highly cytotoxic Shiga toxin, which is also formed by the closely related enterohemorrhagic Escherichia coli (EHEC). It has been shown that tRNA-guanine transglycosylase (TGT) is essential for the pathogenicity of

  1. Linóleo como revestimento de piso: processos construtivos, execução e patologia

    OpenAIRE

    Bastos, Raquel Figueiredo

    2016-01-01

    Dissertação para obtenção do grau de Mestre em Engenharia Civil na Área de Especialização em Edificações Atualmente procura-se construir e reabilitar recorrendo a materiais com qualidade e durabilidade, nomeadamente nos revestimentos de piso, uma vez que são usados de modo permanente e estão sujeitos a elevadas ações mecânicas. A preocupação ambiental também está presente, havendo o cuidado de utilizar materiais sustentáveis que não prejudiquem o ambiente, t...

  2. Comparisons of phaseolin type and α-amylase inhibitor in common bean(Phaseolus vulgaris L.)in China

    Institute of Scientific and Technical Information of China (English)

    Yang Yao; Yibo Hu; Yingying Zhu; Yue Gao; Guixing Ren

    2016-01-01

    The objective of this study was to characterize the phaseolin type and a-amylase(αAI) level in common bean(Phaseolus vidgaris L.) accessions deposited in the Chinese National Genebank.The 40 accessions sampled were common varieties originating in Asia,North America,South America,Europe,and Africa.No Inca(I-) phaseolin was observed in the accessions.Only four accessions contained Tendergreen(T-) phaseolin and the remaining36 contained Sanilac(S-) phaseolin.aAI proteins extracted from nine accessions showed higher a-amylase inhibitory activity than the control(Phase 2,IC50 = 0.65 μg).These common bean accessions have potential use as nutraceutical ingredients.

  3. 深切悼念林耀基教授%In Deep Memory of Prof. Lin Yaoji

    Institute of Scientific and Technical Information of China (English)

    吴祖强

    2009-01-01

    3月16日,星期一清晨,早餐后不久便接到王次炤院长电话,不似平时听惯那样。沉静的语音立即引起了我的不安,感到可能出了什么事情。果然,他略带哽咽地和我说:“刚才从林耀基老师家出来,他今天凌晨去世了……”,

  4. PASS Reference Set Application: Lin UW (2010) TMPRSS2-ERG-PCA-PASS — EDRN Public Portal

    Science.gov (United States)

    Active surveillance is used to manage low-risk prostate cancer. Both PCA3 and TMPRSS2:ERG are promising biomarkers that may be associated with aggressive disease. This study examines the correlation of these biomarkers with higher cancer volume and grade determined at the time of biopsy in an active surveillance cohort.

  5. Influence of various doses of gamma irradiation on the germination and growth of mango (mangifera indica lin) stones

    International Nuclear Information System (INIS)

    Hafiz, I.A.; Malik, F.A.; Ahmad, S.; Asi, A.A.; Khan, M.

    2004-01-01

    Mango stones of the cultivar, Dusehri were administered the Gamma irradiation sourced from cobalt-60 with the doses of 0, 2.5, 5.0, 7.5, 10.00, 12.50 and 15.00 Krd. The results had revealed that the germination percentage was significantly different amongst the treatments, which was slightly improved at 2.5 Krd with the value of 87. 5 %, compared with control (70.25 %), but this pattern showed the reduced trend at higher levels of radiation doses. Germination percentage had geared the negative trend beyond the dose of 2. 5 Krd. Inhibitory effects of radiation were observed pertinent to the average height of seedlings. However, primary leaves appeared serrated in the seedlings emerged from the treated seeds, which turned normal in the subsequent growth of flushes. A new characteristic of lateral branching instead of keeping a single stem was exhibited in the seedlings derived from the treated seeds. The induction of the trait may be used to alter the structure/framework/pattern of the tree canopy. (author)

  6. La filière lin oléagineux française : panorama et perspectives

    Directory of Open Access Journals (Sweden)

    Labalette Françoise

    2011-05-01

    Full Text Available Linseed oil crop production does not succeed in reaching stable acreage in France and does not meet the demand coming from users which incorporate linseeds, which display high content in omega 3 (alpha-linolenic acid, in animal feeding in order to deliver food enriched in omega 3 by natural way (dairy products, eggs, ham.... However, several driving forces should encourage this crop, like the shortfall in linseeds in the European Union and the environmental changes expected from agriculture. That is why the French oilseed crop organisation (Onidol and the French technical institute for oilseed crops (Cetiom launched in 2008 a study about the linseed situation in France. Aim of this work was to get a better understanding of each stage of the linseed chain production from the linseed cultivation to the users and to draw perspectives for the future of this crop in France. To do that a large survey was carried out according to methods adapted to each considered sector. A great attention was given to the progress of the variety offer because the yield gap between linseed and other crops in the rotation is probably one of the most important factors explaining the crop stagnation in France. The synthesis presented in the present paper allows identifying encouraging signals for the future and points the major drawbacks to overcome and the main advantages to take advantage from for developing linseed in France.

  7. Dal mondo dell’arte al regno delle ombre (e ritorno. Arthur Danto, Maya Lin e la bellezza interna

    Directory of Open Access Journals (Sweden)

    Filippo Fimiani

    2012-05-01

    Full Text Available Arthur Danto asserts that Maya Lin’s Vietnam Veterans Memorial in Washington embodies the rhetoric paradigm of internal beauty’s meaning. However, the relationship to the Kant’s pulchritudo adhaerens is not an easy one: Danto’s recalls against the self-referent formalism of Greenberg’s Modernism and his tacit issues about the environmental non-monumentality of Richard Serra’s Minimalism, are, most importantly, haunted by the unquestioned spectral logic of the image embodiment. The beholders’ reflecting shape on the funeral Wall is, finally, both a pathetic index and a medial incarnation (Verkörperung of the underworld.

  8. L'effet thérapeutique de l'huile de lin « linum usitatissimum » sur l ...

    African Journals Online (AJOL)

    client

    l'hypertriglycéridémie et l'hypercholestérolémie chez des rats obèses âgés .... complétées par le test de Tukey afin de classer et comparer les moyennes deux a ..... HARRIS, Fish oils and plasma lipid and lipoprotein metabolism in humans: A ...

  9. Serum levels of triiodothyronine (T3) and thyroxine (T4) in buffalo (Bubalus bubalis Lin.) raised in Amazon region

    International Nuclear Information System (INIS)

    Silva, A.O.A. da.

    1991-08-01

    Through the use of radioimmunoassay (RIA) it was determined blood serum concentration of triiodothyronine (T 3 ) and thyroxine (T 4 ) (n=78) for two different water buffalo racial groups. Blood serum was collected from young and adult animals belonging to two farms in Castanhal country, state of Para, Brazil, through the year of 1988. The serum levels of T 3 and T 4 were statistically correlated with climatic parameters, e.g., pluviometric precipitation, environmental temperature, humidity, light intensity variation and physiological factors such as age, breed and sex. It was identified two seasons during experiment, one season the rainfall period with high precipitation rates and the other one was considered as dry season, with low precipitation rates. The average rate of temperature and humidity have shown no significant statistic difference between the two seasons. On the other hand, it was found a significant relationship between luminosity and seasons, since when the luminosity decreases the pluviometric rates increases. (author). 51 refs, 15 figs, 15 tabs

  10. Limites de bruit quantique et de non-linéarité du canal de communication optique

    Science.gov (United States)

    Desurvire, Emmanuel

    2003-02-01

    We analyze the information-capacity limitations of the optical communication channel, as determined by noise accumulation from optical amplification and nonlinear wave-mixing. We review the concepts of signal-to-noise ratio and entropy for binary-coded and continuous communications, leading to a definition of ultimate capacity for the optically-amplified channel. A unified quantum model, describing both amplification and nonlinearity limitations, makes possible to determine the power transmission window within which the channel capacity can be maximized. To cite this article: E. Desurvire, C. R. Physique 4 (2003).

  11. Genetic algorithm with Lin-Kernighan heuristic as a substep of solving the multinomenclature vehicle routing problem

    Directory of Open Access Journals (Sweden)

    T.A. Yakovleva

    2011-05-01

    Full Text Available This paper is dealing with the vehicle routing problem, where different types of vehicles are managing to deliver different types of products. Three step heuristic with genetic algorithm is proposed for solving the problem.

  12. Possible lin between elevated accumulation of trace elements and canine distemper virus infection in the Caspian seals (Phoca caspica) stranded in 2000 and 2001

    Science.gov (United States)

    Shinsuke, T.; Takashi, K.; Yasumi, A.; Tokutaka, I.; Reiji, K.

    2003-05-01

    In the Caspian Sea, a die-off of thousands of Caspian seals (Phoca caspica) occurred in 1997 and 2000. While a direct cause for these deaths seems to be canine distemper virus (CDV) infection, immunosuppression due to environmental pollutants is considered as one of the possible explanations for the development of the disease. The purpose of this work is to examine whether exposure to trace metals could be one of the factors involved in the mass mortality of Caspian seals. Concentrations of 13 trace elements weredetermined in liver, kidney and muscle of Caspian seals found stranded along the coasts of the Caspian Sea in 2000 and 2001. Concentrations of toxic elemen ts (Ag, Cd, Hg, Tl and Pb) in the Caspian seals collected in 2000 and 2001 were comparable to or lower than those in healthy Caspian seals collected in 1993 and 1998 and in seals from other regions, suggesting that these elements would not be the causative agent for the death of Caspian seals. In contrast, Zn and Fe concentrations in the stranded Caspian seals were apparently higher than those in seals from other locations. These results suggest the disturbance in homeostatic control and nutritional statu s of essential elements in the stranded Caspian seals.

  13. National Rail Network: 1:100,000 (line), Geographic WGS84, BTS (2006) [us_rail_network_100k_lin_BTS_2006

    Data.gov (United States)

    Louisiana Geographic Information Center — The Rail Network is a comprehensive database of the nation's railway system at the 1:100,000 scale. The data set covers all 50 States plus the District of Columbia.

  14. Risques de gel accru liés à la présence d’ouvrages linéaires en remblai

    Directory of Open Access Journals (Sweden)

    Hervé Quenol

    2008-02-01

    Full Text Available Sur un coteau, le remblai d’un ouvrage de transport, en créant un obstacle à l’écoulement naturel de l’air froid superficiel, favorise la formation d’un lac d’air froid. Au printemps, cet obstacle peut accroître le risque de gel dommageable pour les cultures qui sont vulnérables à cet aléa (vigne, arbres fruitiers…. A partir de mesures météorologiques aux échelles fines, réalisées lors des nuits froides de type « radiatives » (vent faible et ciel clair et en simulant le remblai sur une longueur conséquente par l’intermédiaire d’un bâche, il est possible d’évaluer grossièrement le différentiel thermique que va constituer cet ouvrage. Une autre méthode, basée sur la simulation de l’ouvrage en remblai, dans un SIG, et d’une validation sur le terrain aboutit à des résultats proches. Les exemples présentés ici proviennent d’études réalisées ces dernières années sur les remblais des lignes à grande vitesse du TGV Est européen (dans le vignoble de Champagne et du TGV Méditerranée (dans les terroirs arboricoles de la basse vallée de la Durance. Les résultats montrent des différences de températures de plusieurs degrés et aussi une stagnation plus longue de l’air froid superficiel en amont du remblai, ce qui peut provoquer la destruction des jeunes bourgeons. Devant l’importance des problèmes prévisibles, le Maître d’ouvrage a proposé des aménagements afin de réduire au mieux ce risque supplémentaire.By radiativ weather (weak wind and clear sky, an embankment located in below slope level generates an obstacle with the natural flow of the cold air and it develops the formation of cold air lake. In spring, this obstacle can increase the frost risk for the vulnerable cultures (vine, fruit trees.... Weather measurements on fine scales and embankment simulation (with a plastic cover or in a GIS permit to evaluate the temperature difference after the embankment implantation. The examples presented here are the impact of the embankments of high speed lines of the East European TGV (in the Champagne vineyard and of the Mediterranean TGV (in orchards of Durance Valley. The results show a temperature difference of several degrees and also a longer stagnation of cold air surface upstream of the embankment, which can cause the buds destruction. With the importance of the foreseeable problems, the building owner proposed installations in order to reduce this additional risk.

  15. Back-propagation neural network in tidal-level forecasting by Ching-PiaoTsai and Tsong-Lin Lee - Discussion

    Digital Repository Service at National Institute of Oceanography (India)

    Mandal, S.

    relevance to the practicing engineer. Such a scheme of updating parameters (connection weights in the case of neu- ral network) is not employed in the suggested ANN model; thus, the ANN model, where the parameters are estimated from only one-day data... term hourly tidal records. However, there are a number of points to be clarified in order to better understand the paper. This discussion focuses on the following four areas: (1) terminology used in the paper; (2) practical utility; (3) reliability...

  16. A mixed analog-digital radiation hard technology for high energy physics electronics DMILL (Durci Mixte sur Isolant Logico-Linéaire)

    CERN Document Server

    Beuville, E; Borgeaud, P; Fourches, N T; Rouger, M; Blanc, J P; Bruel, M; Delevoye-Orsier, E; Gautier, J; Du Port de Pontcharra, J; Truche, R; Dupont-Nivet, E; Flament, O; Leray, J L; Martin, J L; Montaron, J; Borel, G; Brice, J M; Chatagnon, P; Terrier, C; Aubert, Jean-Jacques; Delpierre, P A; Habrard, M C; Potheau, R; CERN. Geneva. Detector Research and Development Committee

    1992-01-01

    The high radiation level expected in the inner regions of the high luminosity LHC detectors (gamma and neutron) will require radiation hardened electronics. A consortium between the CEA (Commissariat a l'Energie Atomique) and Thomson TMS (Thomson Composants Militaires et Spatiaux) has been created to push for the development and the industrialization of a nascent technology which looks particularly adapted to the needs of HEP electronics. This technology, currently under development at the LETI(CEA), uses a SIMOX substrate with an epitaxial silicon film. It includes CMOS, JFETs and vertical bipolar transistors with a potential multi-megarad hardness. The CMOS and bipolar transistors constitute a rad-hard BiCMOS which will be useful to design analog and digital high-speed architectures. JFETs, which have intrinsically high hardness behaviour and low noise performances even at low temperature will enable very rad-hard, low noise front end electronics to be designed. Present results, together with the improvemen...

  17. Yield stability in maize (Zea mays L. and correlations among the parameters of the Eberhart and Russell, Lin and Binns and Huehn models

    Directory of Open Access Journals (Sweden)

    Carlos Alberto Scapim

    2000-06-01

    Full Text Available Assessment of the stability and adaptability of a genotype to different environments is useful for recommending cultivars for known conditions of cultivation and should be a requirement in breeding programs. Twenty maize (Zea mays L. cultivars were tested at eight locations in Minas Gerais by the National Center for Maize and Sorghum Research (CNPMS of the Brazilian Enterprise for Agricultural Research (EMBRAPA for two years. The experiments involved a randomized complete block design in which three procedures were used to analyze cultivar stability and adaptability. The level of association among the parameters obtained by the three methods was assessed using Spearman's rank correlation. Hybrids 'DINA 170', 'G-96C', 'C 505', 'DINA 70' and 'C 435' had a mean yield greater than 6,000 kg/ha. Eberhart and Russell's regression coefficient (betai was negative and correlated significantly (P or = 0.05, but correlated positively with Si(1 (P O conhecimento sobre a estabilidade e adaptabilidade de comportamento de genótipos contém informações muito úteis para a recomendação de cultivares para condições de cultivo conhecidas a priori, de modo que a avaliação da resposta dos genótipos às variações ambientais deve ser etapa obrigatória em programas de melhoramento. Para caracterizar 20 cultivares de milho, foram realizados dez ensaios (oito localidades do Estado de Minas Gerais, em dois anos no delineamento de blocos ao acaso, pelo Centro Nacional de Pesquisa de Milho e Sorgo (CNPMS da Empresa Brasileira de Pesquisa Agropecuária (Embrapa. Três procedimentos estatísticos foram adotados para a análise da estabilidade e adaptabilidade dos cultivares e avaliou-se o grau de associação entre os parâmetros dos três métodos por meio da correlação classificatória de Spearman. 'DINA 170', 'G-96C', 'C 505', 'DINA 70' e 'C 435' destacaram-se com produtividades médias superiores a 6.000 kg/ha. O coeficiente de regressão (betai de Eberhart e Russell foi negativo e significativamente correlacionado (P ou = 0,05, mas correlacionou-se positiva e significativamente com Si(1 (P < 0,05, indicando que genótipos mais produtivos e responsivos (com menor Pi também podem ser estáveis (com menor Si(1, embora tal situação não seja comumente observada na literatura. Huehn afirma que as estimativas de Si(1 indicam somente estabilidade, quando os dados são corrigidos. Os parâmetros de estabilidade Si(1, Si(2, Si(3 e sigma²di correlacionaram-se positiva e significativamente entre si (P < 0,01, indicando que as estimativas de estabilidade do modelo não-paramétrico de Huehn não acrescentaram maiores informações, além das obtidas pelo método de Eberhart e Russell, ao mesmo tempo que mostram que estimativas de estabilidade de modelos não-paramétricos são alternativas úteis às estimativas de modelos paramétricos. 'DINA 170', com maior média geral, caracterizou-se como um cultivar adaptado para ambientes favoráveis e permaneceu entre os mais produtivos no conjunto de ambientes avaliados. 'G-96C' comportou-se como um cultivar de média adaptação a todos os ambientes (cultivar ideal e estável, enquanto 'C 505' e 'C 435' podem ser considerados alternativos para a 'G-96C'. 'DINA 70', também de adaptabilidade geral, caracterizou-se como de baixa estabilidade.

  18. Polimorfismos en la longitud de fragmentos amplificados (AFLP´s) a partir de muestras de sangre almacenadas en tarjetas FTA® para la especie Cavia porcellus Lin. (Rodentia: Caviidae)

    OpenAIRE

    Burgos-Paz, William; Rosero-Galindo, Carol; Cárdenas-Henao, Heiber; Solarte-Portilla, Carlos

    2007-01-01

    Una manera eficaz de establecer el grado de variabilidad entre y dentro de poblaciones, es a través del análisis de polimorfismos de ADN con marcadores moleculares como los AFLP`s. En este artículo se presenta una metodología que combina la utilización de tarjetas de FTA® (Whatman Bioscience, Cambridge) para colección y conservación de muestras de sangre, con los procedimientos de extracción de ADN y obtención de marcadores AFLP´s, aspectos sobre los cuales no existen antecedentes para la esp...

  19. Characterization of Lin'an montmorillonite and its application in the removal of Ni{sup 2+} from aqueous solutions

    Energy Technology Data Exchange (ETDEWEB)

    Tan, X.L.; Hu, J.; Zhou, X.; Wang, X.K. [Inst. of Plasma Physics, Chinese Academy of Sciences, Hefei (China); Yu, S.M. [School of Chemical Engineering, Hefei Univ. of Tech., Hefei (China)

    2008-07-01

    Clay minerals have been studied extensively because of their strong sorption and complexation ability. In this work, Na-montmorillonite was characterized by using acid-base titration, XRD and FTIR in detail. Sorption of Ni(II) on Na-montmorillonite was investigated under ambient conditions as a function of pH, ionic strength, and temperature. The results indicate that sorption of Ni{sup 2+} on montmorillonite are strongly dependent on pH and ionic strength. The sorption of Ni{sup 2+} is mainly dominated by ion exchange at low pH values and by inner-sphere surface complexation at high pH values. The relationships of pH-C{sub eq}, Q-C{sub eq} and pH-Q are compared and shown clearly in a 3-D plot, and all Q-C{sub eq} data lie in a straight line with slope (- V/m) and intercept (C{sub 0}V/m). The thermodynamic parameters ({delta}H , {delta}S , and {delta}G ) are calculated from the temperature dependent sorption isotherms, and the results suggest that the sorption reaction of Ni(II) from solution to montmorillonite is endothermic and spontaneous. (orig.)

  20. Innovació en educació. De la idea a l’acció. Procés participatiu cap a l'INNED 2

    Directory of Open Access Journals (Sweden)

    Artur Parcerisa-Aran

    2011-06-01

    Full Text Available Per al progrés de l’educació, la innovació és indispensable. Aquest concepte, que es relaciona però no s’ha de confondre amb el de canvi, no tothom l’entén igual, i això fa que sigui necessari definir quines són les característiques que ha de tenir un procés perquè es pugui considerar una innovació educativa. A partir de la preocupació per ajudar a fer que les innovacions no es quedin només en idees sinó que esdevinguin realitats a les aules i en altres espais educatius, es va engegar un procés de trobades amb professorat i altres educadors i educadores per treballar sobre la innovació educativa de cara a l’organització del II Simposi d’Innovació Educativa (INNED 2. Un dels eixos que va suscitar més interès va ser el de la innovació metodològica. En la part final de l’article es recullen una sèrie de consideracions sobre alguns àmbits que cal considerar en aquesta innovació: la implicació de l’alumnat, l’organització de l’espai i el temps, l’avaluació per aprendre i l’atenció a la diversitat.

  1. Proposition d'une méthode d'alignement de l'accélérateur linéaire CLIC

    CERN Document Server

    Touzé, Thomas; Mainaud-Durand, H

    2011-01-01

    The compact linear collider (CLIC) is the particles accelerator project proposed by the european organization for nuclear research (CERN) for high energy physics after the large hadron collider (LHC). Because of the nanometric scale of the CLIC leptons beams, the emittance growth budget is very tight. It induces alignment tolerances on the positions of the CLIC components that have never been achieved. The last step of the CLIC alignment will be done according to the beam itself. It falls within the competence of the physicists. However, in order to implement the beam-based feedback, a challenging pre-alignment is required : 10 μm at 3σ along a 200 m sliding window. For such a precision, the proposed solution must be compatible with a feedback between the measurement and repositioning systems. The CLIC pre-alignment will have to be active. This thesis does not demonstrate the feasibility of the CLIC active prealignment but shows the way to the last developments that have to be done for that purpose. A metho...

  2. Commande de systèmes linéaires sous contraintes fréquentielles et temporelles – Application au lanceur flexible

    OpenAIRE

    Chambon , Emmanuel

    2016-01-01

    In modern control design problems, both frequency- and time-domain requirements are usually considered such that the resulting control law satisfies the specifications. Novel non-smooth optimisation techniques can be used to achieve multiple frequency-domain specifications over a family of linear models. Examples of applications include robust control design where multiple critical models for different values of the uncertain parameters are considered. This is illustrated in this thesis manus...

  3. Release of Halide Ions from the Buried Active Site of the Haloalkane Dehalogenase LinB Revealed by Stopped-Flow Fluorescence Analysis and Free Energy Calculations

    Czech Academy of Sciences Publication Activity Database

    Hladílková, Jana; Prokop, Z.; Chaloupková, R.; Damborský, J.; Jungwirth, Pavel

    2013-01-01

    Roč. 117, č. 46 (2013), s. 14329-14335 ISSN 1520-6106 R&D Projects: GA ČR GBP208/12/G016 Grant - others:GA ČR(CZ) GAP207/12/0775 Program:GA Institutional support: RVO:61388963 Keywords : access tunnel * buried active site * catalytic activity * enzyme mechanism * haloalkane dehalogenase * halide ions Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 3.377, year: 2013

  4. Caenorhabditis elegans Histone Deacetylase hda-1 Is Required for Morphogenesis of the Vulva and LIN-12/Notch-Mediated Specification of Uterine Cell Fates

    OpenAIRE

    Ranawade, Ayush Vasant; Cumbo, Philip; Gupta, Bhagwati P.

    2013-01-01

    Chromatin modification genes play crucial roles in development and disease. In Caenorhabditis elegans, the class I histone deacetylase family member hda-1 , a component of the nucleosome remodeling and deacetylation complex, has been shown to control cell proliferation. We recovered hda-1 in an RNA interference screen for genes involved in the morphogenesis of the egg-laying system. We found that hda-1 mutants have abnormal vulva morphology and vulval-uterine connections (i.e., no uterine-sea...

  5. Review: SERUYA, Teresa; D´HULST, Lieven; ASSIS ROSA, Alexandra; LIN MONIZ, Maria. Translation in Anthologies and Collections (19th and 20th Centuries. Amsterdam: John Benjamins, 2013.

    Directory of Open Access Journals (Sweden)

    Paulo Henrique Pappen

    2016-09-01

    Full Text Available http://dx.doi.org/10.5007/2175-7968.2016v36n3p351 Translation in Anthologies and Collections (19th and 20th Centuries, como outros livros que abordam a questão, é produto de um evento organizado em 2010. Ao todo, são 16 artigos no volume, agrupados em três tópicos: “Discursive practices and scholarly agency”; “National and international canonization processes”; e “Selection and censorship”, em uma obra inteiramente redigida em inglês (menos o texto do espanhol Sabio Pinilla e publicada pela John Benjamins, bom indicador do público ao qual se dirige. Uma operação acertada parece ser a que guia a escolha do título, que ao invés de tentar antecipar uma definição de “antologias traduzidas”, ou “antologias de literatura traduzida”, propõe o guarda-chuva mais abarcador da “tradução em antologias e coleções”. Ou seja, o interesse passa a ser localizar a mediação tradutiva nessas obras.

  6. Using the value of Lin's concordance correlation coefficient as a criterion for efficient estimation of areas of leaves of eelgrass from noisy digital images.

    Science.gov (United States)

    Echavarría-Heras, Héctor; Leal-Ramírez, Cecilia; Villa-Diharce, Enrique; Castillo, Oscar

    2014-01-01

    Eelgrass is a cosmopolitan seagrass species that provides important ecological services in coastal and near-shore environments. Despite its relevance, loss of eelgrass habitats is noted worldwide. Restoration by replanting plays an important role, and accurate measurements of the standing crop and productivity of transplants are important for evaluating restoration of the ecological functions of natural populations. Traditional assessments are destructive, and although they do not harm natural populations, in transplants the destruction of shoots might cause undesirable alterations. Non-destructive assessments of the aforementioned variables are obtained through allometric proxies expressed in terms of measurements of the lengths or areas of leaves. Digital imagery could produce measurements of leaf attributes without the removal of shoots, but sediment attachments, damage infringed by drag forces or humidity contents induce noise-effects, reducing precision. Available techniques for dealing with noise caused by humidity contents on leaves use the concepts of adjacency, vicinity, connectivity and tolerance of similarity between pixels. Selection of an interval of tolerance of similarity for efficient measurements requires extended computational routines with tied statistical inferences making concomitant tasks complicated and time consuming. The present approach proposes a simplified and cost-effective alternative, and also a general tool aimed to deal with any sort of noise modifying eelgrass leaves images. Moreover, this selection criterion relies only on a single statistics; the calculation of the maximum value of the Concordance Correlation Coefficient for reproducibility of observed areas of leaves through proxies obtained from digital images. Available data reveals that the present method delivers simplified, consistent estimations of areas of eelgrass leaves taken from noisy digital images. Moreover, the proposed procedure is robust because both the optimal interval of tolerance of similarity and the reproducibility of observed leaf areas through digital image surrogates were independent of sample size. The present method provides simplified, unbiased and non-destructive measurements of eelgrass leaf area. These measurements, in conjunction with allometric methods, can predict the dynamics of eelgrass biomass and leaf growth through indirect techniques, reducing the destructive effect of sampling, fundamental to the evaluation of eelgrass restoration projects thereby contributing to the conservation of this important seagrass species.

  7. 3D-LIN: A Configurable Low-Latency Interconnect for Multi-Core Clusters with 3D Stacked L1 Memory

    OpenAIRE

    Beanato, Giulia; Loi, Igor; De Micheli, Giovanni; Leblebici, Yusuf; Benini, Luca

    2012-01-01

    Shared L1 memories are of interest for tightly- coupled processor clusters in programmable accelerators as they provide a convenient shared memory abstraction while avoiding cache coherence overheads. The performance of a shared-L1 memory critically depends on the architecture of the low-latency interconnect between processors and memory banks, which needs to provide ultra-fast access to the largest possible L1 working set. The advent of 3D technology provides new opportunities to improve the...

  8. Planification des activités en logistique inverse : modélisation et optimisation des performances par une approche stochastique en programmation linéaire

    OpenAIRE

    Fall , Alioune

    2016-01-01

    During the last decades, reverse logistics networks have been launched in severalindustrialized countries with the aim of preserving the environment. The implementation andmanagement of the reverse logistics concerns the different levels (strategic, tactical andoperational) existing in the framework of forward logistics for any production system. Toimprove this type of network, modeling and simulation are effective tools. After presenting astate of the art in this domain, our study focuses on...

  9. Development of System Architecture to Investigate the Impact of Integrated Air and Missile Defense in a Distributed Lethality Environment

    Science.gov (United States)

    2017-12-01

    SYSTEM ARCHITECTURE TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT by Justin K. Davis...TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT 5. FUNDING NUMBERS 6. AUTHOR(S) Justin K...ARCHITECTURE TO INVESTIGATE THE IMPACT OF INTEGRATED AIR AND MISSILE DEFENSE IN A DISTRIBUTED LETHALITY ENVIRONMENT Justin K. Davis Lieutenant

  10. Serum levels of triiodothyronine (T{sub 3}) and thyroxine (T{sub 4}) in buffalo (Bubalus bubalis Lin.) raised in Amazon region; Niveis sericos de triiodotironina (T{sub 3}) e tiroxina (T{sub 4}) em bubalinos (Bubalus bubalis Lin.) criados na regiao Amazonica

    Energy Technology Data Exchange (ETDEWEB)

    Silva, A O.A. da

    1991-08-01

    Through the use of radioimmunoassay (RIA) it was determined blood serum concentration of triiodothyronine (T{sub 3}) and thyroxine (T{sub 4}) (n=78) for two different water buffalo racial groups. Blood serum was collected from young and adult animals belonging to two farms in Castanhal country, state of Para, Brazil, through the year of 1988. The serum levels of T{sub 3} and T{sub 4} were statistically correlated with climatic parameters, e.g., pluviometric precipitation, environmental temperature, humidity, light intensity variation and physiological factors such as age, breed and sex. It was identified two seasons during experiment, one season the rainfall period with high precipitation rates and the other one was considered as dry season, with low precipitation rates. The average rate of temperature and humidity have shown no significant statistic difference between the two seasons. On the other hand, it was found a significant relationship between luminosity and seasons, since when the luminosity decreases the pluviometric rates increases. (author). 51 refs, 15 figs, 15 tabs.

  11. Loovlinn - kultuuriga vääristatud turismitoode / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2005-01-01

    Panu Lehtovuori ja Justin O'Connoriga kultuuritööstusest ja loovate linnade loomisest. Selgitatakse kultuuritööstuse, loovlinnade ja loovtööstuse mõisteid. Manchesteri ülikooli professor Justin O'Connor esines linnaruumi teemalisel seminaril Eesti Kunstiakadeemias. Seminari korraldas kunstiakadeemia urbanistika õppetooli juhtima asuv Panu Lehtovuori

  12. Dicty_cDB: SLG867 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available PFFKSNLN*lin**lssgci*nvnnn**liixxxxiiiiimiiynn***qfffv lfvifypliyfpr Translated Amino Acid sequence (All Fra...IS NFNNNSPFFKSNLN*lin**lssgci*nvnnn**liixxxxiiiiimiiynn***qfffv lfvifypliyfpr Hom

  13. Determinación cualitativa de factores antinutricionales en las especies, Erithryna Poeppigiana (Walp. O. F, Trichanthera Gigantea (H y B, Morus Alba Lin, en la época de lluvia y seca.

    Directory of Open Access Journals (Sweden)

    Yandy Rodríguez Ledesma

    2014-09-01

    Full Text Available El trabajo se realizó en La Finca “La Perla”, en la localidad de Topes de Collantes, municipio de Trinidad, provincia Sancti Spíritus. Se investigó la presencia de algunos grupos de metabolitos secundarios (fenoles, taninos condensados, saponinas, cianógenos y alcaloides en la biomasa comestible de tres especies arbóreas Las muestras se pesaron y se secaron al sol. El extracto se obtuvo a partir de 5 kg de muestra con 50 ml de etanol al 95 %. Para la descripción cualitativa de los resultados se observó visualmente en la muestra la opalescencia (+, Turbidez definida (++ y precipitado (+++ y, según los resultados observados se utilizaron los siguientes criterios: presencia leve +, Moderada ++ y, abundante +++. El 100% de las especies analizadas, mostraron la presencia de factores antinutricionales; los taninos, tripterpenos y saponinas fueron los metabolitos de mayor presencia en las especies estudiadas. En la época de lluvia los taninos, alcaloides, tripterpenos, antocianinas y cumarinas se encontraron en niveles bajos. En la época de sequía no se encontraron flavonoides y las antocianinas y cumarinas estuvieron en niveles bajos.

  14. Modélisation non-linéaire des effets centrifuges pour le développement de modèles réduits de composants aubagés

    OpenAIRE

    Khalifeh , E; Piollet , E; Millecamps , A; Batailly , Alain

    2017-01-01

    International audience; The modeling of centrifugal stiffening effects on bladed components is of primary importance in order to accurately capture their dynamics depending on the rotor angular speed. Centrifugal effects impact both the stiffness of the component and its geometry. In the context of the small perturbation framework, when considering a linear finite element model of the component, an assumption typically made in the scientific literature involves a fourth-order polynomial devel...

  15. RNA-Binding Protein L1TD1 Interacts with LIN28 via RNA and is Required for Human Embryonic Stem Cell Self-Renewal and Cancer Cell Proliferation

    OpenAIRE

    Närvä, Elisa; Rahkonen, Nelly; Emani, Maheswara Reddy; Lund, Riikka; Pursiheimo, Huha-Pekka; Nästi, Juuso; Autio, Reija; Rasool, Omid; Denessiouk, Konstantin; Lähdesmäki, Harri; Rao, Anjana; Lahesmaa, Ritta

    2012-01-01

    Human embryonic stem cells (hESC) have a unique capacity to self-renew and differentiate into all the cell types found in human body. Although the transcriptional regulators of pluripotency are well studied, the role of cytoplasmic regulators is still poorly characterized. Here, we report a new stem cell-specific RNA-binding protein L1TD1 (ECAT11, FLJ10884) required for hESC self-renewal and cancer cell proliferation. Depletion of L1TD1 results in immediate downregulation of OCT4 and NANOG. F...

  16. Analyse de la dynamique non-linéaire et du contrôle des instabilités de combustion fondée sur la "Flame Describing Function" (FDF)

    OpenAIRE

    Boudy , Frédéric

    2012-01-01

    This thesis is concerned with an investigation of combustion instabilities in premixed combustors. This problem has been the subject of a continuous effort in relation with the many issues encountered in practical systems like those used in propulsion and energy production. Combustion instabilities usually arise from the coupling between combustion and acoustic eigenmodes of the system. In most cases such resonances lead to vibrations, structural fatigue and intensified heat fluxes to the cha...

  17. Efecto de la concentración de linóculo y la melaza como suplemento de la vinaza de destilería para la producción de biomasa de Candida utilis nativa

    Directory of Open Access Journals (Sweden)

    Lady Cajo

    2011-01-01

    Full Text Available La vinaza es un residuo de las destilerías de alcohol, rico en materia orgánica y sales minerales, cuyo aprovechamiento está limitado y finalmente es vertido al alcantarillado, ocasionando contaminación, no obstante, puede constituir un sustrato par a la producción de biomasa de levaduras, utilizadas en la alimentación animal. En la presente investigación se determinó el efecto de la concentración del inóculo y la melaza como suplemento de la vinaza, para la producción de biomasa de Candida utilis nativa. Las levaduras se aislaron de panca de Zea mays L. “maíz” en agar Sabouraud glucosado, identificando el 40.23 % como C. utilis. Luego, se cultivaron en vinaza con 30 g/L de melaza, a 28 ºC, durante 24 horas, se pesó la biomasa y se seleccionó C. utilis MKJ12, debido a que alcanzó el mayor valor de 7.667 g/L. Esta levadura en concentraciones de 25, 50 y 75 mL/L de inóculo se cultivó en biorreactores tipo tanque, en lote discontinuo, conteniendo 300 mL de vinaza con 10, 30, y 50 g/L de melaza, con flujo de aire descendente (1vvm, y una incubación a 28 ºC, durante 20 horas. Con 50 mL/L de inóculo y 50 g/L de melaza se determinó el menor tiempo de generación (2.88 h y los mayores valores en el número de generaciones (6.95, tasa específica de crecimien to (0.35 h - 1 , peso de biomasa (11.78 g/L y proteína (40.15 %. Se demostró la factibilidad de la producción de biomasa de C. utilis con 5 mL/L de inóculo en vinaza suplementada con melaza.

  18. Fonctionnalisation et photopolymérisation de l'huile de lin en vue de l'élaboration de nouveaux matériaux sans émissions de composés organiques volatiles (COV)

    OpenAIRE

    Zovi , Ornella

    2009-01-01

    The use of renewable sources such as vegetable oils in the elaboration of various industrial materials has been recently revitalized because of the environmental concerns. This is in this context that the elaboration of new materials mainly based on linseed oil was envisaged. These new materials were elaborated in three stages, by means of an easy and clear process. The first stage consisted in a thermal or stand reaction, followed or preceded by a chemical modification stage by maleic anhydr...

  19. Wpływ humianu sodowego z węgla brunatnego na rozwój roślin [Effect of sodium humate from lignite on plants grown under various culture conditions

    Directory of Open Access Journals (Sweden)

    Z. Gumińska

    2015-06-01

    Full Text Available The effect of humate on the uptake of Fe-ions has already been proved. In the present paper other advantages of humate are indicated. If plants are grown in optimum conditions humate has no effect. In more concentrated solutions humate acts as a preventive factor and provides for more economical use of the solution (yield increase 40%. When high doses of P and Cu are used, humate weakens their harmful effect on plants; with pH too low or too high, it acts protectively. Humate was tested also in the transplantation of vegetatively propagated young orchid plants from sterile conditions into a natural medium; in that case it also showed a protective effect.

  20. Odporność grzyba Botryotinia fuckeliana (De Bary Whetzel (Botrytis cinerea Pers. – patogena malin, truskawek i innych roślin uprawnych na fungicydy benzimidazolowe [Resistance of Botryotinia fuckeliana (De Bary Whetzel (Botrytis cinerea Pers. to benzimidazole fungicides

    Directory of Open Access Journals (Sweden)

    E. Arseniuk

    2015-06-01

    Full Text Available In the period 1975-1977 forms of the fungus Botrytis cinerea were found in Poland resistant to benzimidazole fungicides. The incidence of the resistant forms increases with the more intensive use of these fungicides. The resistance of Botrytis cinerea to benzimidazole compounds is a cross-resistance involving the whole group of these agents, nowithstanding wihich of them was applied. The resistance acquired by the fungus does not change its reaction to other prophylactic fungicides.

  1. Haruldaste liikide visuaalse loendamise metoodilistest probleemidest keskkonnakorralduses = Methodical problems of species`visual counting in environmental management : I koht bakalaureusetööde kategoorias / Livia Pošlin

    Index Scriptorium Estoniae

    Pošlin, Livia

    2009-01-01

    Bakalaureusetöö eesmärgiks oli imitatsioonilise matemaatilise modelleerimise meetodeid kasutades anda soovitusi suletud maastikul liikuva väikese arvukusega populatsiooni tiheduse määramise optimaalse strateegia leidmiseks

  2. Contrôle des systèmes rapides non linéaires - Application au moteur à allumage commandé turbocompressé à distribution variable

    OpenAIRE

    Colin , Guillaume

    2006-01-01

    Spark ignition engine control has become a major issue for the compliance with emissions legislation while ensuring driving comfort.Engine downsizing is one of the promising ways to reduce fuel consumption and resulting CO2 emissions. Combining several existing technologies such as supercharging and variable valve actuation, downsizing is a typical example of the problems encountered in Spark Ignited (SI) engine control : nonlinear systems with saturation of actuators ; numerous major physica...

  3. Comment on “High-temperature soft magnetic properties of antiperovskite nitrides ZnNFe3 and AlNFe3” by Yankun Fu, Shuai Lin, and Bosen Wang, J. Magn. Magn. Mater. 378 (2015) 54–58

    International Nuclear Information System (INIS)

    Scholz, T.; Leineweber, A.; Dronskowski, R.

    2016-01-01

    The authors of the aforementioned manuscript have recently claimed the synthesis of the ternary nitrides ZnNFe 3 (=ZnFe 3 N) and AlNFe 3 (=AlFe 3 N), ordered substituted variants of the binary phase γ‘-Fe 4 N [1]. While soft ferromagnets of such kind are presently attracting lots of attention, their history dates back for more than half a century. In particular, Al-substituted γ‘-Fe 4 N has already been mentioned in 1961 [2], and the existence of AlFe 3 N has also been claimed in 2009 [3] from a two-step ammonolysis reaction combining a high-temperature sintering step and a low-temperature nitriding reaction [4]. Nonetheless, one of us had to withdraw the latter claim after finding out, by means of scanning-electron microscopy and elemental mapping, that all samples of “AlFe 3 N” consisted of an intimate solid mixture of γ‘-Fe 4 N and amorphous Al 2 O 3 [5]. From what follows, we have strong reasons to believe that the authors of Ref. [1] overlooked our findings [5] and also did not synthesize ZnFe 3 N and AlFe 3 N. - Highlights: • The synthesis of ZnFe 3 N and AlFe 3 N is questioned. • The diffraction data of ZnFe 3 N and AlFe 3 N resemble those of Fe 4 N. • The magnetic data of ZnFe 3 N and AlFe 3 N are compatible with those of Fe 4 N. • There is no physical evidence for the existence of ZnFe 3 N and AlFe 3 N.

  4. Association of the −243A>G, +61450C>A Polymorphisms of the Glutamate Decarboxylase 2 (GAD2) Gene with Obesity and Insu¬lin Level in North Indian Population

    OpenAIRE

    Jai PRAKASH; Balraj MITTAL; Shally AWASTHI; Neena SRIVASTAVA

    2016-01-01

    Background: Obesity associated with type 2 diabetes, and hypertension increased mortality and morbidity. Glutamate decarboxylase 2 (GAD2) gene is associated with obesity and it regulate food intake and insulin level. We investigated the association of GAD-2gene −243A>G (rs2236418) and +61450C>A (rs992990) polymorphisms with obesity and related phenotypes.Methods: Insulin, glucose and lipid levels were estimated using standard protocols. All subjects were genotyped (PCR-RFLP) method.Resu...

  5. Multivariate Generalized Linear Mixed Models with High Complexity / Modèles linéaires généralisés mixtes multivariés avec complexité élevée

    DEFF Research Database (Denmark)

    Labouriau, Rodrigo

    . À titre d'exemple, je présenterai quelques applications à la génétique quantitative avec complexité élevée (plusieurs centaines de milliers d'observations et des pedigrees profonds). Dans toutes les applications présentées, il est essentiel de comprendre le processus stochastique sous-jacent associé...

  6. Conception, construction et essai d'un accélérateur linéaire à protons impulsé à 3 GHz (LIBO) pour la thérapie du cancer

    CERN Document Server

    Berra, Paolo; De Conto, J M; Demeyer, A; Gerard, J P; Hoffmann, H F; Remillieux, J; Bajard, M; Rosso, E; Szeless, Balázs; Weiss, M

    2005-01-01

    In the last ten years the use of proton beams in radiation therapy has become a clinical tool for treatment of deep-seated tumours. LIBO is a RF compact and low cost proton linear accelerator (SCL type) for hadrontherapy. It is conceived by TERA Foundation as a 3 GHz Linac Booster, to be mounted downstream of an existing cyclotron in order to boost the energy of the proton beam up to 200 MeV, needed for deep treatment (~25 cm) in the human body. With this solution it is possible to transform a low energy commercial cyclotron, normally used for eye melanoma therapy, isotope production and nuclear physics research, into an accelerator for deep-seated tumours. A prototype module of LIBO has been built and successfully tested with full RF power at CERN and with proton beam at INFN Laboratori Nazionali del Sud (LNS) in Catania, within an international collaboration between TERA Foundation, CERN, the Universities and INFN groups of Milan and Naples. The mid-term aim of the project is the technology transfer of the ...

  7. Théorie de Perron-Frobenius non linéaire et méthodes numériques max-plus pour la résolution d'équations d'Hamilton-Jacobi

    OpenAIRE

    Qu , Zheng

    2013-01-01

    Dynamic programming is one of the main approaches to solve optimal control problems. It reduces the latter problems to Hamilton-Jacobi partial differential equations (PDE). Several techniques have been proposed in the literature to solve these PDE. We mention, for example, finite difference schemes, the so-called discrete dynamic programming method or semi-Lagrangian method, or the antidiffusive schemes. All these methods are grid-based, i.e., they require a discretization of the state space,...

  8. Salvia officinalis (Lamiaceae) Lin. : caracterização química, atividade citotóxica e apoptótica em células de mamíferos

    OpenAIRE

    Garcia, Charlene Silvestrin Celi

    2014-01-01

    Salvia officinalis (Lamiaceae), conhecida popularmente como sálvia, tem sido muito utilizada no sul do Brasil como condimento nos alimentos, tintura hidroalcoólica e chá para o tratamento de vários distúrbios de saúde. As propriedades dessa planta são estudadas por apontar possíveis mecanismos de ação antioxidante e antitumoral. Neste trabalho, o extrato hidroalcoólico e aquoso de sálvia foram analisados quimicamente por meio de cromatografia gasosa acoplada a espectrômetro de massas (GC-MS) ...

  9. Eestlastest tippjuhid kerge südamega võõrsile leiba teenima ei lähe / Mait Raava, Indrek Neivelt, Maive Rute ; interv. Tuuliki Kasonen-Lins

    Index Scriptorium Estoniae

    Raava, Mait

    2006-01-01

    Pro Konsultatsioonide juhtimiskonsultant Mait Raava, Bank Saint Petersburgi nõukogu esimees Indrek Neivelt, Euroopa Komisjoni innovatsiooni ja väikeettevõtluse üksuse direktor Maive Rute vastavad küsimustele, mis puudutavad Eesti juhtide mainet ning töötamist välisriikides

  10. A Cross-Grade Study Validating the Evolutionary Pathway of Student Mental Models in Electric Circuits

    Science.gov (United States)

    Lin, Jing-Wen

    2017-01-01

    Cross-grade studies are valuable for the development of sequential curriculum. However such studies are time and resource intensive and fail to provide a clear representation to integrate different levels of representational complexity. Lin (Lin, 2006; Lin & Chiu, 2006; Lin, Chiu, & Hsu, 2006) proposed a cladistics approach in conceptual…

  11. 75 FR 76648 - Proposed Establishment of Area Navigation (RNAV) Routes; Western United States

    Science.gov (United States)

    2010-12-09

    ... routes would improve departure flow from the San Francisco/Oakland, CA, Terminal area by providing...'' N., long. 107[deg]55'30'' W.) * * * * * Q-128 LIN to MEM [New] LIN VORTAC (Lat. 38[deg]04'29'' N...'' W.) * * * * * Q-130 LIN to PNH [New] LIN VORTAC (Lat. 38[deg]04'29'' N., long. 121[deg]00'14'' W...

  12. 76 FR 13084 - Establishment of Area Navigation (RNAV) Routes; Western United States

    Science.gov (United States)

    2011-03-10

    ... Francisco/Oakland, CA, Terminal area by providing additional parallel departure routings and improve arrival....) * * * * * * * Q-128 LIN to MEM [New] LIN VORTAC (Lat. 38[deg]04[min]29[sec] N., long. 121[deg]00[min]14[sec] W...] W.) * * * * * * * Q-130 LIN to PNH [New] LIN VORTAC (Lat. 38[deg]04[min]29[sec] N., long. 121[deg]00...

  13. Case report

    African Journals Online (AJOL)

    raoul

    2011-08-16

    Aug 16, 2011 ... ... due to exuberant immune responses to occult or apparent opportunistic infections or cancers. ... A full blood count revealed a packed cell volume of 28% and total .... Stebbing Justin, Portsmouth Simon, Gazzard Brain.

  14. Plaadid / Priit Juurmann

    Index Scriptorium Estoniae

    Juurmann, Priit

    2006-01-01

    Uutest heliplaatidest Alexkid "Caracol", Bob Dylan "Modern Times", Justin Timberlake "Future Sex", Ilves, Pulk ja Rahman "Murõt ei olõ", Audioslave "Revelations", Bill Frisell "Bill Frisell, Ron Carter, Paul Motian", Julie & Khari "Moon Bossa"

  15. Lean Manufacturing Principles Guide, Version 0.5. A Guide to Lean Shipbuilding

    National Research Council Canada - National Science Library

    Liker, Jeffrey K; Lamb, Thomas

    2000-01-01

    .... Through years of trial and error on the shopfloor Toyota discovered that they could simultaneously achieve high quality, low cost, and just-in time delivery by shortening the production flow by eliminating waste...

  16. Children's Brain Tumor Foundation

    Science.gov (United States)

    ... 2 Family Donate Volunteer Justin's Hope Fund Children’s Brain Tumor Foundation, A non-profit organization, was founded ... and the long term outlook for children with brain and spinal cord tumors through research, support, education, ...

  17. Histopathology of Polymicrogyria

    Directory of Open Access Journals (Sweden)

    Iga Fudyma

    2015-12-01

    Full Text Available Investigators from Sainte Justine Hospital (Montreal, Montreal Neurological Hospital and Institute, King's College Hospital (London, and John Radcliffe Hospital (Oxford retrospectively reviewed medical records, autopsy reports, and genetic studies containing “Polymicrogyria.”

  18. 78 FR 54663 - National Vaccine Injury Compensation Program; List of Petitions Received

    Science.gov (United States)

    2013-09-05

    .... Julie Cochran on behalf of John James Bieber, Deceased, Dayton, Tennessee,, Court of Federal Claims No... of Justin Ryker Swick, Deceased, Iowa Falls, Iowa, Court of Federal Claims No: 13-0526V 32. Megan...

  19. Antioxidant benzophenones and xanthones from the root bark of ...

    African Journals Online (AJOL)

    Antioxidant benzophenones and xanthones from the root bark of Garcinia smeathmannii. Alain Meli Lannang, Justin Komguem, Fernande Ngounou Ngninzeko, Jean Gustave Tangmouo, David Lontsi, Asma Ajaz, Muhammad Iqbal Choudhary, Beiban Luc Sondengam, Atta -ur-Rahman ...

  20. "Lilja 4-everi" õppetund / Kaur Kender

    Index Scriptorium Estoniae

    Kender, Kaur, 1971-

    2003-01-01

    Suures osas Paldiskis filmitud Rootsi mängufilm "Lilja 4-ever" : režissöör Lukas Moodysson. Filmi peategelase Lilja saatuse võrdlus markii de Sade'i romaani "Justine ehk Vooruse õnnetused" nimitegelase omaga

  1. Room-Temperature Single-Photon Source for Secure Quantum Communication

    Data.gov (United States)

    National Aeronautics and Space Administration — We are asking for four years of support for PhD student Justin Winkler's work on a research project entitled "Room temperature single photon source for secure...

  2. Idoldyrkelse

    OpenAIRE

    Pedersen, Lærke; Jessen, Frida Julie; Dyjak, Sofie; Isaqzai, Hossai; Winther, Line Sandra; Henriques, Marie Simone Malmborg; Jagielska, Anna Pipi Olivia

    2014-01-01

    This project examines the subject of celebrity idolisation on the basis of a specific case: fans of contemporary pop-icon Justin Bieber. The examination of this subject is made on the basis of classical theories: mass psychology by Le Bon and psychoanalysis by Freud. The project includes an analysis of these theories and their psychological ideas based on an interview with three girls who worship Justin Bieber. This analysis aims to explore why a person worships a celebrity, and concludes tha...

  3. The city as a sign

    DEFF Research Database (Denmark)

    Kharlamov, Nikita

    2012-01-01

    . This question is tackled through Jaan Valsiner’s notions of semiotic mediation and regulation. I specifically focus on spatial signs that humans use to regulate the meaning-making process that creates as meaningful what Georges Perec called species of spaces, such as towns and cities. “The city,” from...... this standpoint, becomes one of the most important signs that mediate and regulate our experience of environments we inhabit. I discuss a number of theoretical and methodological directions in which this framework could be further developed to revive the urban, or settlement, psychology, which failed to develop...... Werner, and Bernard Kaplan, and developed as cultural-developmental approach by Jaan Valsiner, the proposed framework centers on the experience of individual organismic relating to spatial environment. I draw on the work of Manuel Castells, Edward Soja, and Yi-Fu Tuan to conceptualize the emergence...

  4. Topofobia e topofilia em “A Terra”, de “Os Sertões”: uma análise ecocrítica do espaço sertanejo euclidiano / Topophobia and topophilia in”The Land” of “Os Sertões”: Analysis ecocriticism of space Sertanejo Euclideano

    Directory of Open Access Journals (Sweden)

    Edilane Ferreira da Silva

    2014-08-01

    Full Text Available In 1902, the journalist Euclides da Cunha published the work Os Sertões which, starting Pre-Brazilian Modernism and enhance Bahia´s backlands from the Canudos War. We analyze the chapter “The Earth” of the Euclidean book, in order to examine the discourse method analysis and the ecocriticism perspective - which concerns the interactions between literature and ecology - the author approaches between the backwoods and wilderness, and his own feelings regarding this space, considering topophobia concepts - aversion to physical environment and topophilia - familiarity or attachment, proposed by the chinese geographer Yi-Fu Tuan and related humanistic geography. Thus, the present discourse in the narrative demonstrate predominance of dislikes and horror feelings for the caatinga, regarding the subjectivity of the writer and oikos referenced by him.

  5. How Many Women Are Affected by or at Risk of Preeclampsia?

    Science.gov (United States)

    ... pregnancy outcomes: Differences among 4 racial/ethnic groups. American Journal of Public Health, 95 (9), 1545–1551. Lin, H. C., Chen, S. F., Lin, H. C., & Chen, Y. H. (2010). Increased risk of adverse pregnancy outcomes ...

  6. Therapeutic effects of Laser and L-carnitine against amiodarone ...

    African Journals Online (AJOL)

    Pulmonary toxicity is considered a life- threatening complication of ... Research Center, Faculty of Medicine, Ain .... Laser therapy restores the balance between oxidants and ... No conflict of interest associated with this work. Contribution of .... Fitness. 2014; 149-159. 21. Lee BJ, Lin JS, Lin YC, Lin PT. Effects of L-carnitine.

  7. Water Activated Doping and Transport in Multilayered Germanane Crystals

    Science.gov (United States)

    2015-09-21

    Justin Young, Basant Chitara , Nicholas Cultrara , Maxx Q Arguilla , Shishi Jiang, Fan Fan , Ezekiel Johnston-Halperin, Joshua E Goldberger 611102 c...Crystals Justin R Young1, Basant Chitara2, Nicholas D Cultrara2, Maxx Q Arguilla2, Shishi Jiang2, Fan Fan2 Ezekiel Johnston-Halperin1, Joshua E...Optoelectronics ACS Nano 7 5660-5 [9] Zhang Y, Tan Y-W, Stormer H L and Kim P 2005 Experimental observation of the quantum Hall effect and Berry’s phase in

  8. [The constribution of Justyne Siegemundin, the midwife of the Brandenburg court, to the development of the obstetrics at XVII century].

    Science.gov (United States)

    Kraśnianin, Elzbieta; Semczuk, Andrzej

    2006-12-01

    From the beginning of the world assisting during childbirth was and is the women's domain. On the evolution this profession composed of many famous midwifes. Into this group unquestionably we can count Justine Siegemundin (1636-1705), midwife-self-taught person. Her activity contributed to rise the obstetrics knowledge in XVII century. Justine Siegemundin, the midwife of the Brandenburg court, published in 1690 a book describing a surgical trick still bears her name today. It is called the "double hold"--"Gedoppelter Handgriff", or "Siegemundin-Handgriff". This book counts as on the most important milestones of obstetrics history.

  9. 專論/論搜尋引擎以程式在網路上自動抓取資料時可能面臨之法律問題及其解決之道/廖先志;陳鍾誠 | The Possible Legal Issues about Crawlers and Their Resolutions/ Hsien-Jyh Liao;Yi-Hsuan Lin

    Directory of Open Access Journals (Sweden)

    廖先志、陳鍾誠

    2007-04-01

    Full Text Available

    搜尋引擎必須以Crawler程式(又稱spider程式)來自動抓取網頁並建立索引,如果Crawler程式僅僅循著網頁所提供的超連結來搜尋網 頁並抓取內容,稱為一般性的Crawler程式:如果不論網頁是否提供超連結,Crawler程式會自行計算並找到網頁的所有內容並加以抓取,此種 Crawler則稱為深度Crawler。而Crawler抓取網頁內容的步驟可以細分為「取得資料」及「儲存並建立索引」二大步驟。在「取得資料」階段 中,深度Crawler雖然是自行透過演算法來取得網頁的所有內容,但本文認為仍不至於構成非法存取(unauthorized access。此外,不論是一般的Crawler或是深度Crawler,如果取得網頁內容時會耗費網站資源而干擾網站的正常運作,就可能構成如美國 eBdy案中討論的財產侵害(trespass to chattel。在「儲存並建立索引」階段中,原則上應該不會侵害網頁擁有者之重製權,然而、有些搜尋引擎(例如Google將其取得的內容以「庫存 頁面」( Cache的方式允許使用者存取,此時即有爭議發生,但本文以為,由於搜尋引擎的主要目的是在使網路使用者更容易接觸網頁,所以此種「重製」與「散布」 行為原則上應有著作權法「合理使用」原則的適用,故不會構成侵害著作權,但仍應考慮搜尋引擎與原網站之間是否處於競爭關係,以及所抓取之資料量佔原網站之 比例等因素綜合判斷。要解決搜尋引擎與網站間可能發生的法律爭議,除可以強化現行的robot exclusion標準外,網站也可以考慮增強自動過濾Crawler的功能,以杜絕爭議。


    A Search engine uses a crawler (or a spider to retrieve and index web pages. A “general crawler” crawls across the Internet by following only the hyperlinks directly provided by web pages. On the other hand, a “deep crawler” has the capability of retrieving all contents of web pages whether the hyperlinks are available or not. The process of a crawler’s work can be split into two major steps: the “retrieving” step and the “storage and indexing” step. As far as the retrieving step is concerned, even though a deep crawler can generate all URLs by itself, there should not be any unauthorized access at all. However, a crawler, either a general or deep one, will be charged with trespassing to chattel if it interferes in the website, whereas, in the “storage and indexing” step, owners’ copyright of web pages will in principle not be infringed upon by a crawler. Nevertheless, there are controversies about “cache”, which is provided by certain popular search engines, such as Google and Yahoo. Search engines may claim their fair use defense of “cache”, because one of the main goals of search engines is to improve access to information on the internet. Actually, we must consider many factors before we decide whether “cache” is fair or not, for instance, whether there is competition between the search engine and the retrieved web sites; and what percentage of the contents is retrieved by the crawler, etc. To resolve all possible legal conflicts between crawlers and web pages, among several economic resolutions, a newer and complete robot exclusion standard is required. In addition, a self-detecting mechanism adopted by web pages may be even a more powerful one.

    頁次:53-66

  10. Stages of maturation of the fruit on germination and oil content in seeds of Jatropha curcas LinEstádios de maturação do fruto no desempenho germinativo e teor de óleo de sementes de Jatropha curcas Linn

    Directory of Open Access Journals (Sweden)

    Fernanda Rubio

    2013-05-01

    Full Text Available Jatropha curcas Linn., known as physic nut, is a plant that has oil content between 35 and 38%, being used as an alternative for producing biodiesel. However, this culture has uneven fruiting, which discourages the harvest period. This study aimed to relate the color of the seeds during fruit maturation and germination characteristics with the oil concentration, confirming the best time for harvest. Using the Munsell color chart the seeds were classified into four stages: VC (light seeds of unripe fruits, VE (dark seeds of unripe fruits, A (seeds of fruits attached to the tree and C (seeds to the ground. It was conducted the germination test, moisture, dry matter and oil content. The seeds of fruits that were attached to the tree (level A obtained better results in test of germination, about 25% because they had higher dry matter (90.51% and lower water content (9.49%. They also had the largest concentration of oil, which was 47.36% (almond, and therefore, the best stage for harvesting. The light seeds of unripe fruits (VC, did not obtain satisfactory germination (1.25%, indicating that the color of the fruits can be a parameter for physiological maturity of Jatropha curcas Linn.Jatropha curcas Linn. conhecido como pinhão manso apresenta teor de óleo entre 35 e 38% em suas sementes, sendo utilizado como alternativa na produção de biodiesel. Porém, essa cultura apresenta frutificação desuniforme, o que desfavorece a determinação do período ideal de colheita. Desta forma, esse trabalho objetivou relacionar a coloração das sementes de Jatropha curcas Linn. durante o processo de maturação dos frutos com as características germinativas e concentração de óleo, verificando assim a melhor época para a colheita. Utilizando a carta de cores de Munsell, as sementes foram classificadas em 4 estádios: VC (sementes claras de frutos verdes, VE (sementes escuras de frutos verdes, A (sementes de frutos maduros presos à árvore e C (sementes ao chão. Foi realizado o teste de germinação, umidade, matéria seca e teor de óleo das sementes. As sementes dos frutos secos presos à árvore (estádio A resultaram em maior germinação, cerca de 25%, pois possuíam maior massa seca (90.51% e menor teor de água (9.49%. No estádio A as sementes apresentaram também a maior concentração de óleo, que foi de 47.36% (amêndoa, sendo, portanto, o estádio mais indicado para a colheita dos frutos. As sementes claras de frutos verdes (VC, não apresentaram germinação satisfatória (1.25%. A cor do fruto é um parâmetro para indicação de maturidade fisiológica de sementes de Jatropha curcas Linn.

  11. Une méthode de calcul par éléments finis de la résistence de vague des corps flottants ou immergés en théorie linéaire A Finite Elements Method for Computing the Resistance of Floating Or Submerged Bodies to Wave Action Using a Linear Theory

    Directory of Open Access Journals (Sweden)

    Cariou A.

    2006-11-01

    Full Text Available Pour calculer le potentiel de l'écoulement autour d'un corps en mouvement rectiligne uniforme, soit en fluide illimité (engin sous-marin, soit sur une mer infinie (corps flottant ou voisin de la surface libre, on se place dans le cadre du problème de Neumann extérieur ou du problème de Neumann Kelvin. Pour résoudre ces problèmes on se propose de délimiter autour de la carène un domaine fluide fini (,ri dont les frontières sont : la carène (SC, une surface (SE entourant la carène et éventuellement la portion de surface libre (SI. limitée par les lignes de flottaison de SC et SE. La solution à l'intérieur de (,ri est déterminée à l'aide d'une méthode d'éléments finis et elle est raccordée à la solution en domaine infini elle-même calculée grâce aux fonctions de Green du problème (ou solutions élémentaires. For computing the flow potential around a body in uniform rectilinear movement, either in an unlimited fluid (subsea croft or on an infinite sea (body floating near the free surface, consideration must be given ta the outside Neumann problem or ta the Neumann Kelvin problem. Ta solve these problems, this article proposes ta delimit a finite fluid realm (T: around the body. The limits of this realm are: I the body (SC, 2 a surface (SE surrounding the body, and eventually 3 the portion of free surface (SU bounded by the waterlines of SC and SE. The solution within iri is determined by a finite elements method, and it is related ta the solution in on infinite realm which in turn is computed by the Green functions of the problem (or elementary solutions.

  12. 專論/部落格使用者的資訊行為特徵研究/高世樺;林頌堅 | A Study of Features of Blog Users' Information Behaviors / Shih-Hua Kao; Sung-Chien Lin

    Directory of Open Access Journals (Sweden)

    高世樺、林頌堅

    2008-04-01

    Full Text Available

    部落格已經成為諸多新科技中最具有影響力的媒體之一,並對於使用者的資訊尋求行為造成影響。本研究整理部落格的相關概念及功能,並以二十位部落格使 用者的訪談結果對部落格上的資訊尋求行為特徵進行描述。研究結果顯示,使用者在部落格的開始動機、連結方式、辨別標準、監看與提取方式等等都展現了十分豐 富的行為特徵,研究並發現;(1情感聯繫是受訪者經常提及的使用目標,並且這種動機也影響了各種行為特徵;(2使用者會依照自我的需求以及所處的情境 發展出合適的使用方式,這些新使用方式可能不同於發明者與推廣者所設想的最便於使用的功能;(3部落格上的個人經驗是使用者進行資訊尋求的主要原因之 一;(4豐富而精緻的圖像經常能夠吸引使用者進入部落格。

    Blog has already become one of the most influential media among new technologies, and has impacted on users’ information seeking behaviors. This research  utilized an interview survey to explore related concepts and unique functions of blog media. Interviews with 20 blog users were completed and analyzed to depict characteristics of information seeking behaviors founded in the use of blogs. The result shows that the users had performed a variety of behavioral features in motivations of using blogs, ways of linking from one blog to another, criteria of identification among blogs, methods of blog monitoring and extracting and so forth. Some major observations were also found during the interviews conducted: (1 emotion connection is frequently mentioned by users as one of their main purposes of using blogs, which can be found in each characteristic of information seeking behaviors; (2 when users use new functions of blog, based on their respective needs and situations they can develop their own strategies and methods, which can be very different from those provided or assumed by inventors and promoters; (3 personal experience shared by bloggers is one of the primary reasons why users employ blogs to find information needed; (4 abundant and delicate images embedded in blogs can always attract users’ attention.

    頁次:62-77

  13. Wpływ niektórych detergentów na przyrost biomasy Solanum lycopersicum i Scenedesmus quadricauda oraz na akumulację składników mineralnych u tych roślin [The effect of some detergents on the increase in biomass and the accumulation of mineral components in Solanum lycopersicum and Scenedesmus quadricauda

    Directory of Open Access Journals (Sweden)

    St. Gumiński

    2015-01-01

    Full Text Available The investigation on water cultures of tomato seedlings and Scenedesmus quadricauda colonies have shown that low doses of the detergents stimulate the growth of these plants. An intensified accumulation of N, P, Ca, Mg, Fe and a reduced accumulation of K-ions have been observed.

  14. Custom Type-Curve Generation for Pressure Transient Analysis of Elongated Linear Flow Systems Génération de courbes caractéristiques de réponse en pression pour des systèmes linéaires longs

    Directory of Open Access Journals (Sweden)

    Wagner P. B.

    2006-11-01

    Full Text Available When the drainage area of a flowing well is long and narrow, the pressure transient behavior of the well often cannot be analyzed by conventional means. Well tests which appear to exhibit linear flow behavior for extended periods, beyond the length of time which could be attributed to flow to a fracture, have been observed for both geothermal wells and for oil and gas wells. In geothermal formations and in some of the deep low-permeability gas fields the elongated reservoir shape results from long parallel faults which appear to bound the formations. Typically such wells are also penetrating natural fractures. In other reservoirs the elongated drainage shape is due to the river delta or alluvial environment in which the reservoir sands were originally deposited. Using a recently developed scheme for custom type curve generation for a wide variety of flow geometries, the particular behavior of the well producing from an elongated linear flow system is presented in detail. Cases examined include fractured wells of variable fracture length in varions positions within the flow channel and also of variable length. The effects of partial penetration are also demonstrated. This paper illustrates the use of custom type curves in computer-aided type-curve matching. With the help of relatively inexpensive computer graphics, custom type curves are displayed which exactly represent whatever is known about a particular drainage geometry, including such variables as formation thickness and areal extent, fracture length, partial penetration, and well location. Familles of curves can be generated and displayed along with the data to help determine unknown features of the reservoir geometry. An important contribution included in this work was the development of a set of orthogonal dimensionless parameters which facilitate the generation of familles of type curves which vary one reservoir shape parameter with implied effects on other parameters. The dimensionless solutions for any reservoir geometry are then readily developed for use in computer-aided type curve matching. Lorsque la zone de drainage d'un puits de production est longue et étroite, les méthodes classiques d'analyse du comportement des changements de pression ne peuvent être utilisées. De tels comportements, se prolongeant après la période pouvant être attribuée à une fracture, ont été observés pour des puits produisant de l'huile, du gaz et même pour certains puits géothermiques. La géométrie allongée, que l'on rencontre parfois dans certaines formations géothermiques et poches de gaz à grande profondeur et de faible perméabilité, peut être expliquée par des réseaux de fractures parallèles qui limitent la formation. Naturellement, les puits forés dans de telles formations peuvent traverser des fractures naturelles. Pour d'autres réservoirs, la forme allongée peut être causée par la géométrie de l'environnement dépositionnel deltaïque. Utilisant une méthode récemment développée permettant de produire des courbes caractéristiques de changement de pression pour une grande variété de géométries, le comportement particulier des puits drainant des formations allongées est présenté en détail. Les cas suivants ont été analysés : fissuration avec modification de la longueur de la fracture et diverses positions du puits dans la formation avec pénétration partielle de différentes longueurs. Les courbes sont construites directement sur le terminal. Elles prennent en compte exactement ce qui est connu de la géométrie du réservoir, de l'épaisseur, la forme, la longueur de la fissure, de la longueur de la zone perforée et de la position du puits. Des familles de courbes peuvent être générées et affichées, puis comparées aux données pour déterminer les paramètres inconnus de la géométrie du réservoir. Une contribution importante, présentée dans cet article, est le développement d'un système de paramètres orthogonaux sans dimensions qui facilite la génération des courbes caractéristiques. Les courbes caractéristiques de pression, correspondant à des géométries spécifiques à l'utilisateur, peuvent être superposées aux données de pressions en vue de déterminer les paramètres inconnus du réservoir (type curve matching.

  15. Comment on “High-temperature soft magnetic properties of antiperovskite nitrides ZnNFe{sub 3} and AlNFe{sub 3}” by Yankun Fu, Shuai Lin, and Bosen Wang, J. Magn. Magn. Mater. 378 (2015) 54–58

    Energy Technology Data Exchange (ETDEWEB)

    Scholz, T. [Chair of Solid-State and Quantum Chemistry, Institute of Inorganic Chemistry, Landoltweg 1, RWTH Aachen University, D-52056 Aachen (Germany); Leineweber, A. [Institute of Materials Science, TU Bergakademie Freiberg, Gustav-Zeuner-Str. 5, D-09599 Freiberg (Germany); Dronskowski, R., E-mail: drons@HAL9000.ac.rwth-aachen.de [Chair of Solid-State and Quantum Chemistry, Institute of Inorganic Chemistry, Landoltweg 1, RWTH Aachen University, D-52056 Aachen (Germany)

    2016-10-15

    The authors of the aforementioned manuscript have recently claimed the synthesis of the ternary nitrides ZnNFe{sub 3} (=ZnFe{sub 3}N) and AlNFe{sub 3} (=AlFe{sub 3}N), ordered substituted variants of the binary phase γ‘-Fe{sub 4}N [1]. While soft ferromagnets of such kind are presently attracting lots of attention, their history dates back for more than half a century. In particular, Al-substituted γ‘-Fe{sub 4}N has already been mentioned in 1961 [2], and the existence of AlFe{sub 3}N has also been claimed in 2009 [3] from a two-step ammonolysis reaction combining a high-temperature sintering step and a low-temperature nitriding reaction [4]. Nonetheless, one of us had to withdraw the latter claim after finding out, by means of scanning-electron microscopy and elemental mapping, that all samples of “AlFe{sub 3}N” consisted of an intimate solid mixture of γ‘-Fe{sub 4}N and amorphous Al{sub 2}O{sub 3}[5]. From what follows, we have strong reasons to believe that the authors of Ref. [1] overlooked our findings [5] and also did not synthesize ZnFe{sub 3}N and AlFe{sub 3}N. - Highlights: • The synthesis of ZnFe{sub 3}N and AlFe{sub 3}N is questioned. • The diffraction data of ZnFe{sub 3}N and AlFe{sub 3}N resemble those of Fe{sub 4}N. • The magnetic data of ZnFe{sub 3}N and AlFe{sub 3}N are compatible with those of Fe{sub 4}N. • There is no physical evidence for the existence of ZnFe{sub 3}N and AlFe{sub 3}N.

  16. 實徵研究/國小教師以CREATER模式推動資訊素養創新課程之歷程/謝佩紋;林菁|The Process of Elementary School Teachers Implementing an Innovation Curriculum of Information Literacy with CREATER Model/Pei-Wen Hsieh; Lin Ching Chen

    Directory of Open Access Journals (Sweden)

    謝佩紋、林菁 Pei-Wen Hsieh; Lin Ching Chen

    2009-04-01

    Full Text Available 本研究旨在探究國小教師推動資訊素養創新課程的歷程,並以CREATER革新模式的七個階段為架構,深入瞭解教師作為創新推動者在每個階段的經歷及結果,以提供有意推動資訊素養理念或其它創新的教育工作者參考。本研究採個案研究,以南部一所國小為研究個案,研究時間歷時一年半,透過觀察、訪談、文件分析等方法進行資料的蒐集。研究結果發現,國小教師推動資訊素養課程的歷程大致與CREATER模式的七個階段相符,但「關心」、「連結」與「檢視」階段並無明顯次序,教師以組織內成員的角色推動創新,能有效地將創新理念化為行動,但行動能否持續及發揮效果,還有賴團隊組成的完整性、教師的持續更新力及組織內掌握實權者的支持與參與。The purpose of this study was to explore the change process of implementing an information literacy curriculum by elementary school teachers. Based on the CREATER model, this study investigated the teachers’ experiences as change agents in each stage of the process. The research results could provide guidelines for educators who are devoted to promote the information literacy or other innovations. The method of case study was used to design this study. The subjects of this study were the teachers who voluntarily implemented the information literacy curriculum in an elementary school in the southern part of Taiwan. The methods for collecting research data were observations, interviews, and document analyses. The research results showed that the change process of implementing the information literacy curriculum corresponded to the seven stages of the CREATER model. However, the stages of “care,” “relate,” and “examine,” did not obviously happen in sequence. As members of the organization, the teachers could transform effectively the innovative concept into an action, but whether the innovation could be persistent depended on team relationships, teachers’ self-renewal capacity, and approvals and participation of the leaders who really managed the organization.頁次:70-89

  17. Aplicación del Método de Monte Carlo a la Planificación en Radioterapia y a la Reconstrucción de Espectros de Fotones de Aceleradores Lineales de Partículas (LinAc)

    OpenAIRE

    Juste Vidal, Belen Jeanine

    2011-01-01

    La radioterapia es uno de los tratamientos más generalizados aplicados a los pacientes que padecen determinados tipos de cáncer. Sin embargo, la efectividad de este tipo de tratamientos en la destrucción de las células cancerígenas lleva asociada la posibilidad de sufrir los efectos secundarios de la radiación sobre los tejidos sanos circundantes. El riesgo de lesión de las células sanas depende fundamentalmente de la orientación del haz emitido por la unidad de radioterapia y de la intensida...

  18. 75 FR 74002 - Fresh Garlic From the People's Republic of China: Extension of Time Limit for Preliminary Results...

    Science.gov (United States)

    2010-11-30

    ... DEPARTMENT OF COMMERCE International Trade Administration [A-570-831] Fresh Garlic From the People... Trading, Inc.), Milton Koch (Jining Yifa Garlic Produce Co., Ltd.), Justin Neuman (Shenzhen Bainong Co... Department published the initiation of the new shipper reviews of the antidumping duty order on fresh garlic...

  19. Embedding JIT into MRP

    NARCIS (Netherlands)

    Flapper, S.D.P.; Miltenburg, G.J.; Wijngaard, J.

    1991-01-01

    Today many companies who are using MRP production control systems are investigating how they can produce some or all of their products using just-in time (JIT) principles. They wonder to what extent MRP can provide support for JIT production. This paper describes how JIT can be embedded into MRP. A

  20. Becoming a Youth Activist in the Internet Age: A Case Study on Social Media Activism and Identity Development

    Science.gov (United States)

    Fullam, Jordan

    2017-01-01

    This paper draws on a case study of one youth activist, and explores connections between social media activism, identity development, and critical education. Justin Rodriguez, a 17-year-old high school student in Newark, New Jersey, leveraged social media and texting as organizing tools and garnered support for a school walkout to protest…

  1. Extended Independent Comparison of Popular Deep Packet Inspection (DPI) Tools for Traffic Classification

    DEFF Research Database (Denmark)

    Bujlow, Tomasz; Carela-Español, Valentín; Barlet-Ros, Pere

    ), Sopcast, Spotify, Steam, TOR, and World of Warcraft. The included web services are: 4Shared, Amazon, Apple, Ask, Bing, Blogspot, CNN, Craigslist, Cyworld, Doubleclick, eBay, Facebook, Go.com, Google, Instagram, Justin.tv, LinkedIn, Mediafire, MSN, Myspace, Pinterest, Putlocker, QQ.com, Taobao...

  2. Developing Senior Leaders’ Family and Social Strength in the Operational Army

    Science.gov (United States)

    2013-04-01

    April 2007): 87. 19 Joe Doty & Jeff Fenlason, “ Narcissism and Toxic Leaders,” Military Review Online, (January-February 2013): 55-60. 20...Generations at Work (New York, NY: Amacom, 2010). 40Justin Menkes, “ Narcissism : The Difference Between High Achievers and Leaders,” Harvard Business

  3. Coalition Warfare Program Tactile Situation Awareness System for Aviation Applications: Simulator Flight Test

    Science.gov (United States)

    2015-12-01

    David Myers1 Timothy Gowen2 Angus Rupert3 Ben Lawson3 Justin Dailey3,4 1Chesapeake Technology International 2Naval Aviation Center for... Angus Rupert of the USAARL. The algorithm is described in “Configuration Parameters for the Tactile Situation Awareness System (TSAS)” dated July 2010

  4. Operational art in the Defense: The German Abwehrschlachten in 1918

    Science.gov (United States)

    2012-05-17

    Siegismund, 1937), 74. 21 Jacob Jung, Max von Gallwitz (1852-1937) (Osnabrück: Biblio -Verlag, 1995), 93 & 97. 22 Erich Ludendorff, Meine...Goerre-Verlag, 2003. 44 Jung, Jakob. Max von Gallwitz (1852-1937). Osnabrück: Biblio -Verlag, 1995. Kelly, Justin, and Michael J. Brennan. "The

  5. Resonance – Journal of Science Education | Indian Academy of ...

    Indian Academy of Sciences (India)

    Home; Journals; Resonance – Journal of Science Education; Volume 19; Issue 2. Why Some Pool Shots are More Difficult Than Others. Justin Jankunas Richard N Zare. General Article Volume 19 Issue 2 February 2014 pp 116-122. Fulltext. Click here to view fulltext PDF. Permanent link:

  6. Advanced Concept Architecture Design and Integrated Analysis (ACADIA)

    Science.gov (United States)

    2017-11-03

    1 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) Submitted to the National Institute of Aerospace (NIA) on...Research Report 20161001 - 20161030 Advanced Concept Architecture Design and Integrated Analysis (ACADIA) W911NF-16-2-0229 8504Cedric Justin, Youngjun

  7. Support for Implications of Compressive Sensing Concepts to Imaging Systems

    Science.gov (United States)

    2015-08-02

    Justin Romberg Georgia Tech jrom@ece.gatech.edu Emil Sidky University of Chicago sidky@uchicago.edu Michael Stenner MITRE mstenner@mitre.org Lei Tian...assessment of image quality. Michael Stenner Michael has broad interests in optical imaging, sensing, and communications, and is published in such

  8. Evaluation of heavy metal uptake and translocation by Acacia ...

    African Journals Online (AJOL)

    Jane

    2011-08-08

    Aug 8, 2011 ... Acacia mangium as a phytoremediator of copper contaminated soil. Nik M. Majid, M. M. Islam*, Veronica Justin, Arifin Abdu and Parisa Ahmadpour. Department of ... The different levels of Cu were: T0 (control, soil), T1 (50 ppm Cu), T2 (100 ppm ..... aspects such as photosynthesis and respiration rate need.

  9. Dual Optical Comb LWIR Source and Sensor

    Science.gov (United States)

    2017-10-12

    Justin M. Brown, Mark G. Allen Physical Sciences Inc. (PSI) Pierre Jouy, Jérôme Faist Swiss Federal Institute of Technology (ETH) Markus Geiser...Research, Development & Engineering Center Name of Contractor: Physical Sciences Inc. Principal Investigator: Dr. Joel M. Hensley Business...including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and

  10. Kernel-Based Approximate Dynamic Programming Using Bellman Residual Elimination

    Science.gov (United States)

    2010-02-01

    Redding, Mike Robbins, Frant Sobolic, Justin Teo, Tuna Toksoz, Glenn Tournier, Aditya Undurti, Mario Valenti, Andy Whitten, Albert Wu, and Rodrigo...vector algorithms. Neural Computation, 12(5):1207–1245, 2000. [143] P. Schweitzer and A. Seidman. Generalized polynomial approximation in Markovian

  11. Browse Title Index

    African Journals Online (AJOL)

    Items 151 - 200 of 224 ... Vol 41, No 3 (2014), The Pastoral, the Primal and the Post-Apartheid Sublime in Justin Cartwright's White Lightning, Abstract. D Klopper. Vol 41, No 2 (2014), The Poetics and Politics of Transnational Petro-Environmentalism in Nnimmo Bassey's We Thought It Was Oil but It Was Blood, Abstract.

  12. Art and Sonic Mining in the Archives: Methods for Investigating the Wartime History of Birmingham School of Art

    Science.gov (United States)

    Vaughan, Sian

    2018-01-01

    "Absconditi Viscus" (or "Hidden Entries") is a series of sound compositions based on the history of Birmingham School of Art during the First World War. Sound artist Justin Wiggan explored the concept of historical sonic information that although lost could still potentially permeate the archival record and the fabric of the…

  13. Gestion des forêts domaniales en période de conflits : cas de la forêt ...

    African Journals Online (AJOL)

    Gestion des forêts domaniales en période de conflits : cas de la forêt classée du Haut-Sassandra, Centre-Ouest de la Côte d'Ivoire. Akoua Tamia Madeleine Kouakou, Yao Sadaiou Sabas Barima, Souleymane Konate, Issouf Bamba, Justin Yatty Kouadio, Jan Bogaert ...

  14. Browse Title Index

    African Journals Online (AJOL)

    Items 251 - 300 of 1025 ... Vol 17, No 1 (2003), Speciation of cadmium mixed ligand complexes in salt water lakes, Abstract PDF. John L. Kituyi, Henry M. Thairu, Justin Irina, Knut H. Schroder. Vol 24, No 3 (2010), Spectral characterizations and antibacterial effect of 2-(5-R-1H-benzimidazol-2-YL)-4-methyl/bromo-phenols and ...

  15. 77 FR 17410 - Bottom Mount Combination Refrigerator-Freezers From the Republic of Korea: Final Affirmative...

    Science.gov (United States)

    2012-03-26

    ...: Myrna L. Lobo, Justin M. Neuman, or Milton Koch, AD/CVD Operations, Office 6, Import Administration... Operations, Re: Scope Modification Requests, dated October 26, 2011 (Preliminary Scope Memorandum). [[Page.... KEXIM Export Factoring 2. K-SURE--Export Credit Guarantees 3. Gwangju Metropolitan City Programs A...

  16. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Biosciences. Anshu Aggarwal. Articles written in Journal of Biosciences. Volume 27 Issue 4 July 2002 pp 339-346 Articles. Place prioritization for biodiversity content · Sahotra Sarkar Anshu Aggarwal Justin Garson Chris R Margules Juliane Zeidler · More Details Abstract Fulltext PDF.

  17. Reference: 169 [Arabidopsis Phenome Database[Archive

    Lifescience Database Archive (English)

    Full Text Available e M et al. 2005 Mar. Plant J. 41(5):744-54. The recessive Arabidopsis thalianafumonisin B1-resistant (fbr6) ...opment and sensitivity to fumonisin B1. 5 744-54 15703061 2005 Mar The Plant journal Liang Xinwen|Nekl Emily R|Stiers Justin J|Stone Julie M

  18. Dvě zprávy o raně křesťanské liturgii. Pokus o analýzu narativní struktury

    Czech Academy of Sciences Publication Activity Database

    Fialová, Radka

    -, č. 24 (2014), s. 83-111 ISSN 1805-2762 R&D Projects: GA ČR(CZ) GBP401/12/G168 Institutional support: RVO:67985955 Keywords : Early Christian liturgy * baptism and Eucharist in the 2nd Century * Didache * Justin Martyr's Apology Subject RIV: AA - Philosophy ; Religion https://www.etf.cuni.cz/ sat /2014-1.html

  19. 77 FR 61379 - Performance Review Board Membership

    Science.gov (United States)

    2012-10-09

    ... DEPARTMENT OF COMMERCE Performance Review Board Membership AGENCY: Economics and Statistics... eligible to serve on the Performance Review Board (PRB) in accordance with the Economics and Statistics.... Arnold William G. Bostic, Jr. Joanne Buenzli Crane Justin R. Ehrenwerth Ron S. Jarmin Theodore A. Johnson...

  20. Human Capital Management of Air Force SOF: Leadership Identification, Selection and Cultivation

    Science.gov (United States)

    2017-12-01

    managers, they are now called “People Leaders.” According to Justin Whitman, Senior Human Resources Manager at the Corporate Finance and Audit Staff...Approach to Learning and Development ..........................................50 Figure 7. Corporate Audit Staff Programs...Assignment Interactive Module 2.0 CAS Corporate Audit Staff CEB Corporate Executive Board CEO chief executive officer CFO chief financial officer CLP

  1. High incidence of GJB2 gene mutations among assortatively mating ...

    Indian Academy of Sciences (India)

    High incidence of GJB2 gene mutations among assortatively mating hearing impaired families in Kerala: future implications. Amritkumar Pavithra, Justin Margret Jeffrey, Jayasankaran Chandru, Arabandi Ramesh and C. R. Srikumari Srisailapathy. J. Genet. 93, 207–213. Table 1. Consolidated table of GJB2 mutation status ...

  2. Keeping a (Digital) Eye on Nature's Clock

    Science.gov (United States)

    Magney, Troy; Eitel, Karla; Eitel, Jan; Jansen, Vincent; Schon, Jenny; Rittenburg, Rebecca; Vierling, Lee

    2013-01-01

    Many students probably take pictures daily. Whether snapshots of their friends at a Justin Bieber concert or of their latest skateboard trick, these images document changes in a student's life. Digital cameras can do more, however, than record memories to post on Facebook. They can also help students examine changes in their environment. This…

  3. Filosof Iústinos proroky motivovaný

    Czech Academy of Sciences Publication Activity Database

    Hoblík, Jiří

    2014-01-01

    Roč. 20, č. 1 (2014), s. 53-68 ISSN 1211-1872 R&D Projects: GA ČR(CZ) GBP401/12/G168 Institutional support: RVO:67985955 Keywords : Justin Martyr * prophets * philosophy * Logos * Jesus Christ Subject RIV: AA - Philosophy ; Religion

  4. 78 FR 68151 - Quarterly Publication of Individuals, Who Have Chosen To Expatriate, as Required by Section 6039G

    Science.gov (United States)

    2013-11-13

    ... CLAUDIA FRIEDLANDER ROBERT MAX FRIESEN KATHLEEN ELLEN FUKUNAGA MIWA FULLER NICHOLAS ALAN FULLER NICHOLAS... SHIPLEY ROBERT ANTHONY SIM JEONG SUN SIMON ANTHONY NICHOLAS SIMON JULIE ANN SINN JUSTINE TUNG SITTARO... JAMES TAN YANQIANG TANAKA RYO TANG MARX THERN EDINA RITTER THERN JR ROBERT WILLIAM TIEN LAUREN TSAK YEN...

  5. Science of Security Lablet - Scalability and Usability

    Science.gov (United States)

    2014-12-16

    Cybersecurity_Framework.ashx Byres, Eric and Justin Lowe, 2004, The Myths and Facts behind Cyber Security Risks for Industrial Control Systems, Proceedings of the VDE ...Myths and Facts behind Cyber Security Risks for Industria l Control Systems, Proceedings of the VDE Kongress, 2004. Kshetri, Nir, 2005, Pattern of

  6. Fulltext PDF

    Indian Academy of Sciences (India)

    IAS Admin

    116 Why Some Pool Shots are More Difficult Than Others. Justin Jankunas and Richard N Zare. 122 Some Physics Inside Drying Droplets. Dileep Mampallil. 135 From the Triangle Inequality to the Isoperimetric. Inequality. S Kesavan. 149 Seaweeds. Ancestors of Land Plants with Rich Diversity. Felix Bast. 116. 122. 149 ...

  7. Popmuusika / Mart Juur

    Index Scriptorium Estoniae

    Juur, Mart, 1964-

    2006-01-01

    Uutest heliplaatidest New York Dolls "One Day It Will Please Us To Remember Even This", Missy Elliott "Respect M.E.", Justin Timberlake "Futuresex/Lovesounds", Kelis "Kells Was Here", Beyonce "B'Day", Method Man "4.21... The Day After", Korn "Live & Rare"

  8. Nevidimõi

    Index Scriptorium Estoniae

    2008-01-01

    Ulmeline põnevusfilm "Nähtamatu" ("The Invisible") : režissöör David S. Goyer : osades Justin Chatwin, Margarita Levieva : Ameerika Ühendriigid 2008. Film on uusversioon 2002.a. rootsi samanimelisest filmist ("Deb Osynlige"; Joel Bergvall, Simon Sandquist)

  9. Plaadid / Villu Päärt

    Index Scriptorium Estoniae

    Päärt, Villu, 1972-

    2002-01-01

    Uutest plaatidest Nick Carter "Now Or Never", Brian Mcknight "From There To here 1989-2002", Rod Stuart "The Grat American Songbook", New Order "International", Justin Timberlake "Justified", Manic Street Prachers "Forever Delayed - Greatest Hits", LHB "Tell 'Em Who We Are"

  10. Applying Multiculturalism to a High School American Literature Course: Changing Lenses and Crossing Borders.

    Science.gov (United States)

    Noskin, David; Marshalek, Angela

    1995-01-01

    Describes a nine-week, secondary-school, language arts unit on the American dream with an emphasis on multicultural issues, particularly as they concern those students who are apathetic about or resistant to the multicultural program. Reviews specific lesson approaches to "The Great Gatsby,""Baseball in April,""Justin and…

  11. Rebel Integration in Conflict Settlements: Past Lessons and the Prospects of MILF Reintegration

    Science.gov (United States)

    2017-12-01

    School. I would like to express my sincere gratitude to the Singapore Armed Forces for granting me the Postgraduate Award, and the Naval Leadership of the...the keys to my accomplishments at the Naval Postgraduate School. —Justin Lai At the outset, let me express my gratitude to God Almighty for

  12. Fulltext PDF

    Indian Academy of Sciences (India)

    Roeder I, de Haan G, Engel C, Nijhof W, Dontje B and Loeffler M 1998 ... this question, Justin Harris at the University of New South Wales, Australia ... The next step was to develop a simple test to look at such a transfer of learning in humans.

  13. Päästa enda sisemine hunt valla! / Tanel Veenre

    Index Scriptorium Estoniae

    Veenre, Tanel, 1977-

    2009-01-01

    Ameerika 2008.a. mängufilmist "Mässajate tänav" ("Revolutionary Road"), stsenarist Richard Yates'i samanimelise raamatu järgi Justin Haythe, režissöör Sam Mendes, peaosades Kate Winslet, Leonardo DiCaprio

  14. Unistuste ravi kontrollitud / Andris Feldmanis

    Index Scriptorium Estoniae

    Feldmanis, Andris, 1982-

    2009-01-01

    Ameerika 2008.a. mängufilmist "Mässajate tänav" ("Revolutionary Road"), stsenarist Richard Yates'i samanimelise raamatu järgi Justin Haythe, režissöör Sam Mendes, operaator Roger Deakins, peaosades Kate Winslet, Leonardo DiCaprio

  15. Differences Between British and Americans’ Cultures in Values

    Institute of Scientific and Technical Information of China (English)

    潘巍巍; 戴立黎

    2008-01-01

    <正>Values are the most important issue in identifying one particular culture.Social values are the feelings people have about what is important,worthwhile,and just.In this paper,the differences between British and American values are discussed in two aspects which mainly lie respectively in the comparisons of values and characteristics in both cultures.

  16. IN SEARCH OF THE ORIGINAL TEXT IN MARK 9:38

    African Journals Online (AJOL)

    “Teacher, we saw someone in your name driving out demons and we tried .... Luke.” Maybe Lagrange and Taylor and Cranfield deserve more attention. 5. ..... Justin). In the Revue Biblique (Hendriks 2007:266-271) I divided Mark 8:26 into five ...

  17. Bulletin of the Chemical Society of Ethiopia - Vol 20, No 2 (2006)

    African Journals Online (AJOL)

    Antioxidant benzophenones and xanthones from the root bark of Garcinia smeathmannii · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Alain Meli Lannang, Justin Komguem, Fernande Ngounou Ngninzeko, Jean Gustave Tangmouo, David Lontsi, Asma Ajaz, ...

  18. Mode transition and change in variable use in perceptual learning

    NARCIS (Netherlands)

    Hajnal, A; Grocki, M; Jacobs, DM; Zaal, FTJM; Michaels, CF

    2006-01-01

    Runeson, Justin, and Olsson (2000) proposed (a) that perceptual learning entails a transition from an inferential to a direct-perceptual mode of apprehension, and (b) that relative confidence-the difference between estimated and actual performance-indicates whether apprehension is inferential or

  19. Globaalne konteiner, järjekorranumbriga 8 / Maarin Mürk

    Index Scriptorium Estoniae

    Mürk, Maarin

    2009-01-01

    Kunstikonteineri rahvusvaheline kunsti- ja performance'iüritus "Global Container 8" 27. augustil kultuuritehases Polymer. Justin Tyler Tate'i, Auseklis/Usinsi ja Sandra Jõgeva esinemisest. Tom Russotti ja Ernest Truely ürituse kohta valminud dokumentaalist. Simon B. Haefele vestlusringist teemal "Kunsti võim"

  20. Philostr., Her. XXXV 9-10: ¿un testimonio de Eurísaces de Sófocles?

    Directory of Open Access Journals (Sweden)

    Miryam Librán Moreno

    2005-06-01

    Full Text Available Philostr. Her.. XXXV 9-10 may preserve hints of a rhesis from Sophocles' Eurysaces. Taking that as a departure point, a reconstruction of the general lines of this play is attempted from the evidence supplied by Accius, Pacuvius and Justin, as interpreted through the narrative pattern evinced in Oedipus at Colonus.

  1. Natali Portman : "Ljubov i izmenõ bõli vsegda" / Natalie Portman

    Index Scriptorium Estoniae

    Portman, Natalie

    2008-01-01

    Näitlejanna endast ja oma rollidest, lähemalt rollist uusimas filmis - Suurbritannia - USA mängufilm "Teine Boleyni tüdruk" Philippa Gregory romaani ainetel (režissöör Justin Chadwick) (Tõlgitud väljaandest "Focus")

  2. Exploring the science-policy interface.

    Science.gov (United States)

    Davies, Justine

    2010-04-30

    The sacking of David Nutt from his position as Chair of a UK government science advisory council has thrown the interface between science and policy into sharp relief. Justine Davies takes a look behind the scenes. 2010 Elsevier Inc. All rights reserved.

  3. An Analysis of Navy Nurse Corps Accession Sources

    Science.gov (United States)

    2014-03-01

    1 I. INTRODUCTION A. BACKGROUND Since 1998, the United States has experienced a nationwide nursing shortage (Juraschek, Zhang, Ranganathan ...supply of RNs in the civilian workforce (Juraschek, Zhang, Ranganathan , & Lin, 2012). A study by Juraschek, Zhang, Ranganathan , & Lin (2012...Postgraduate School, Monterey, CA. Retrieved from www.dtic.mil/cgi- bin/GetTRDoc?AD=ADA344570 Juraschek, S. P., Zhang, X., Ranganathan , V. K., & Lin, V

  4. Biochemistry of Microbial Degradation of Hexachlorocyclohexane and Prospects for Bioremediation

    Science.gov (United States)

    Lal, Rup; Pandey, Gunjan; Sharma, Pooja; Kumari, Kirti; Malhotra, Shweta; Pandey, Rinku; Raina, Vishakha; Kohler, Hans-Peter E.; Holliger, Christof; Jackson, Colin; Oakeshott, John G.

    2010-01-01

    Summary: Lindane, the γ-isomer of hexachlorocyclohexane (HCH), is a potent insecticide. Purified lindane or unpurified mixtures of this and α-, β-, and δ-isomers of HCH were widely used as commercial insecticides in the last half of the 20th century. Large dumps of unused HCH isomers now constitute a major hazard because of their long residence times in soil and high nontarget toxicities. The major pathway for the aerobic degradation of HCH isomers in soil is the Lin pathway, and variants of this pathway will degrade all four of the HCH isomers although only slowly. Sequence differences in the primary LinA and LinB enzymes in the pathway play a key role in determining their ability to degrade the different isomers. LinA is a dehydrochlorinase, but little is known of its biochemistry. LinB is a hydrolytic dechlorinase that has been heterologously expressed and crystallized, and there is some understanding of the sequence-structure-function relationships underlying its substrate specificity and kinetics, although there are also some significant anomalies. The kinetics of some LinB variants are reported to be slow even for their preferred isomers. It is important to develop a better understanding of the biochemistries of the LinA and LinB variants and to use that knowledge to build better variants, because field trials of some bioremediation strategies based on the Lin pathway have yielded promising results but would not yet achieve economic levels of remediation. PMID:20197499

  5. New Approaches for Prostate Cancer Combination Therapy

    Science.gov (United States)

    2009-04-01

    Freemont AJ, et al. E - cadherin and h-catenin are down-regulated in prostatic bone metastases. BJU Int 2002;89:400–3. ...ola r Di clo fen ac 20 Di clo fen ac 10 Di clo fen ac 5 Su lin da c S ulf on e 2 00 Su lin da c S ulf on e 1 00 Su lin da c S ulf on e 5 0 Su...lin da c S ulf on e 2 5 Flu rb ipr ofe n 2 0 Flu rb ipr ofe n 1 0 Flu rb ipr ofe n 5 Flu rb ipr ofe n 2 As pir

  6. Orange Houses and Tape Babies Temporary and Nebulous Art in Urban Spaces

    Directory of Open Access Journals (Sweden)

    Carmen L. McClish

    2010-12-01

    Full Text Available This essay argues that the disruption of the routine ways we engage with our cities is necessary for democratic activity and public participation. Building on research that examines the relationship between public spaces and democratic action, I explore temporary forms of creative street installation as interrupting the market-ing pleas that have become the only authorized forms of visual art in our cities. I argue that tactics in urban spaces that are temporary and provide nebulous mean-ings are necessary to grab our attention and make us linger. I propose that these forms of engagement act in the same way as people performing or playing in pub-lic spaces. I specifically employ Yi-Fu Tuan’s theoretical notions of space and movement and Margaret Kohn’s discussion of the significance of presence in pub-lic spaces to examine the creative ways we engage with and experience our cities. I examine two activist/artist projects: Mark Jenkins’ tape installations and Detroit Demolition. My analysis of these two sites demonstrates the importance of citi-zens engaging in their urban spaces. By creating temporary artwork that is nebul-ous in meaning, activists/artists are interrupting the routine ways we experience our cities.

  7. Dai limiti del luogo alle barriere dello spazio

    Directory of Open Access Journals (Sweden)

    Toni Veneri

    2011-05-01

    Full Text Available Renaissance travel literature does not include the experience of the geometrical border yet: it tells about positioning in zones, transitional areas where everything happens. Thus these textual traces increasingly tend to fashion themselves according provisional negotiations between map indicators and route indicators, between description and narration, leading to a balance or a tension between strategies and tactics. The features of the modern map, its formalization and its newly acquired autonomy, depend on this very polarization, on a binarism emerging between spatial setup and material experience of places. Referring to this crucial historical context, this paper would like to consider some apparently divergent definitions of space and place. In the last decades two main trends, respectively oriented to the theoretical redemption of the notion of space (the spatial turn of cultural studies and place (the humanistic turn of geographical disciplines, seem nonetheless to convey towards a shared critique of the rigidity and stability of the concept of place when confronted to the polysemic category of space. If the Aristotelian place as a qualitative limit worked as an authoritative foundation unit for the medieval space of localization, during the Renaissance a quantitative space willing to be an “unlimited place” challenges this well established organization. Considering this process, this paper suggests the possibility, in order to suit a distinction rendered influential by Yi-Fu Tuan in geographical studies, to invert the promising philosophical terms employed by Michel de Certeau to describe the radical changes undergone by geographical imagination in these critical centuries.

  8. 314 A Study of Secondary School Students' Academic Performance ...

    African Journals Online (AJOL)

    User

    Students' Academic Performance in English Language and Mathematics ... passed at credit level by secondary schools students in public examinations. A credit level ..... ls O n lin e: www.a jo l.in fo. T ab le 1. : P ercen tage of p asses and failu.

  9. Photonic-Networks-on-Chip for High Performance Radiation Survivable Multi-Core Processor Systems

    Science.gov (United States)

    2013-12-01

    Loss Spectra” Proceedings of SPIE 8255, (2012) and in a journal publication: M. T. Crowley, D. Murrell, N. Patel, M. Breivik , C.-Y. Lin, Y. Li, B.-O...Crowley, D. Murrell, N. Patel, M. Breivik , C.-Y. Lin, Y. Li, B.-O. Fimland and L. F. Lester, "Analytical Modeling of the Temperature Performance of

  10. Download this PDF file

    African Journals Online (AJOL)

    Dr Olaleye

    Histological assessment of the gastric mucosa and submucosa revealed infiltration by inflammatory cells in normal ... Gastric ulcer, also known as peptic ulcer, is a localized area of erosion in ..... and water retention by interfering with the prostaglandin induced ... Clark JD, Lin LL, Kriz RW, Ramesha CS, Sultzman LA,. Lin AY ...

  11. Single-tube linear DNA amplification for genome-wide studies using a few thousand cells

    NARCIS (Netherlands)

    Shankaranarayanan, P.; Mendoza-Parra, M.A.; Gool, van W.; Trindade, L.M.; Gronemeyer, H.

    2012-01-01

    Linear amplification of DNA (LinDA) by T7 polymerase is a versatile and robust method for generating sufficient amounts of DNA for genome-wide studies with minute amounts of cells. LinDA can be coupled to a great number of global profiling technologies. Indeed, chromatin immunoprecipitation coupled

  12. Aldehyde Dehydrogenase 1 and Raf Kinase Inhibitor Protein ...

    African Journals Online (AJOL)

    Xiang-Xiu Sun1, Qing-Shan Ma2, Tian-Feng Liu1, Ying Chen1, Yan Dong1 and. Lin-Lin Zhang1* ... cancer was developed and studied by histological examination. Immunohistochemical and .... (diaminobenzidine) Kit. Western blot analysis.

  13. 75 FR 4509 - Uniform Criteria for State Observational Surveys of Seat Belt Use

    Science.gov (United States)

    2010-01-28

    ... statistical issues: Ms. Chou-Lin Chen, Chief, Mathematical Analysis Division, National Center for Statistics..., Washington, DC 20590. Telephone number: 202-366-1048; E- mail: Chou-Lin.Chen@dot.gov . For legal issues: Ms..., and reduce burden. E. Paperwork Reduction Act Under the Paperwork Reduction Act of 1995, a person is...

  14. Water SA - Vol 40, No 2 (2014)

    African Journals Online (AJOL)

    The development of GIS-PMWIN and its application for mine-water modelling in the Far West Rand, South Africa · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. H Lin, L Lin, 313-322. http://dx.doi.org/10.4314/wsa.v40i2.13 ...

  15. Face me I face you

    Directory of Open Access Journals (Sweden)

    Mirka Koro-Ljungberg

    2016-11-01

    Full Text Available This iterative and a-signifying sound experimentation project started from simple wonderings that emerged from undocumented college students’ interview data. As the researchers began to reflect on the data provided by these students, conversations around noise and gossip began to emerge. Over time, the conversations about noise and gossip transmogrified into various soundscapes and audio recordings that extended also beyond noise and gossip. "Let’s work more with the sound and try to extend effects and create affects. Maybe produce another extension of that video in such a way that we would still be working with the thing, whatever the thing was" stated Mirka and Justin. Justin would go on to say, "It's less and less representational and signifying. Our sound encounters produce something different than what we originally intended them to be. Or they work, or function as whatever."

  16. Depression og/eller apokalypse

    DEFF Research Database (Denmark)

    Frantzen, Mikkel Krause; Bjering, Jens Christian Borrebye

    2015-01-01

    The article sets out by investigating how depression is represented in Lars von Trier´s disaster movie Melancholia with the specific intent to detach mental illness from classic, somewhat romantic notions of metaphoric and epistemological connections between psychopathology and deeper “truths......” about the world. Employing what one could call a symptomatological view on the depression of the main protagonist Justine, the article concludes that her depression should be seen as a temporal disorder in the sense that she lacks the ability to project and plan a future. From here, the article turns...... to Eve Kosofsky Sedgwick´s concept of a “reparative praxis” as a possible ethico-practical way out of the depressive situation, arguing that such a reparative praxis is exactly what ends up pulling Justine out of her depression and enabling her to act. In a concluding step, the article relates depression...

  17. Blood-brain transfer and antinociception of linear and cyclic N-methyl-guanidine and thiourea-enkephalins

    DEFF Research Database (Denmark)

    Verbeken, Mathieu; Wynendaele, Evelien; Mauchauffee, Elodie

    2015-01-01

    Enkephalins are active in regulation of nociception in the body and are key in development of new synthetic peptide analogs that target centrally located opioid receptors. In this study, we investigated the in vivo blood–brain barrier (BBB) penetration behavior and antinociceptive activity of two...... cyclic enkephalin analogs with a thiourea (CycS) or a N-methyl-guanidine bridge (CycNMe), and their linear counterparts (LinS and LinNMe) in mice, as well as their in vitro metabolic stability. 125I-LinS had the highest blood–brain clearance (K1 = 3.46 μL/g min), followed by 125I-LinNMe, 125I...

  18. Baseline Assessment of Petroleum Contamination and Soil Properties at Contaminated Sites in Utqiagvik, Alaska

    Science.gov (United States)

    2017-08-01

    microbial community, including high bacterial numbers in these soils. The results from this baseline study indicate that stimulating biodegradation...CEERD-RR), ERDC- CRREL. At the time of publication, Dr. Justin Berman was Chief, CEERD- RRN; CDR J. D. Horne, USN (Ret), was Chief, CEERD-RR; and Dr...of the fractions of petroleum hydrocarbons and microbial activity in ERDC/CRREL TR-17-13 3 situ to reveal the status of each site at the time of

  19. Popnädal. Inglismaa TOP 20 Albumid / Aivar Meos

    Index Scriptorium Estoniae

    Meos, Aivar

    2002-01-01

    Okt. lõpus USAs Brooklyni muusikaakadeemias esiettekandele tulevast ooperist "Woyzeck". 12. nov. müügile saabuvast Bondi-filmi "Die Another Day" soundtrackist (filmi nimiloo esitajaks Madonna). Ansamblite Wu-Tang Clani ja Limp Bizkiti plaanidest anda järgmisel aastal välja oma uued albumid. Ansamblist Bet Shop Boys. 4. nov. müügile saabuvast Justin Timberlake'i sooloalbumist "Justified".

  20. Factors that influence exercise activity among women post hip fracture participating in the Exercise Plus Program

    OpenAIRE

    Barbara Resnick; Denise Orwig; Christopher D′Adamo; Janet Yu-Yahiro; William Hawkes; et al

    2007-01-01

    Barbara Resnick1, Denise Orwig2, Christopher D’Adamo2, Janet Yu-Yahiro3, William Hawkes2, Michelle Shardell2, Justine Golden2, Sheryl Zimmerman4, Jay Magaziner21University of Maryland School of Nursing, 655 West Lombard Street, Baltimore, MD,21201, USA; 2University of Maryland School of Medicine, Howard Hall, Redwood Street, Baltimore MD 21201, USA; 3Department of Orthopaedic Surgery, Union Memorial Hospital, Baltimore, USA; 4University of North Carolina Chapel Hill, 301 Pittsboro St., ...

  1. Uyghurs in Xinjiang: United or Divided Against the PRC?

    Science.gov (United States)

    2012-09-01

    them). Uyghurs have responded in stressing even more so their distinction from the Han Chinese people and culture. However, despite this improved...UyghurLanguageUnderAttack.pdf. 10 Justin Rudelson and William Jankowiak. “ Acculturation and Resistance: Xinjiang Identities in Flux,” in Xinjiang: China’s Muslim...the Uyghur people. Rudelson and Jankowiak argue that the responses of the Uyghurs are varied and divided—ranging from acculturation , to non-violent

  2. Energy Guiding and Harvesting through Phonon-Engineered Graphene

    Science.gov (United States)

    2016-01-28

    Graphene The views, opinions and/or findings contained in this report are those of the author(s) and should not contrued as an official Department of the...ABSTRACT Final Report: Energy Guiding and Harvesting through Phonon-Engineered Graphene Report Title The work performed under this proposal was primarily...Justin Wu, Xinran Wang, Kristof Tahy, Debdeep Jena, Hongjie Dai, Eric Pop. Thermally Limited Current Carrying Ability of Graphene Nanoribbons

  3. Ohustatud homopingviinid / Udo Uibo

    Index Scriptorium Estoniae

    Uibo, Udo, 1956-

    2011-01-01

    Ameerika Raamatukoguühingu (American Library Association) sõnavabaduse osakond paneb igal aastal kokku nimekirja raamatutest, mille kohta on esitatud kõige rohkem kaebusi nõudega teose kättesaadavust sobimatu sisu tõttu piirata või teos raamatukogust üldse kõrvaldada. 2010 a. nimekirja juhib Peter Parnelli ja Justin Richardsoni lasteraamat "Tangoga kolmekesi" (And Tango Makes Three), kus lugejad panevad pahaks selle homoseksuaalsust, religioosseid vaateid ja sobimatust laste lugemisvaraks

  4. In vitro Toxicity and Inflammatory Response Induced by Copper Nanoparticles in Rat Alveolar Macrophages

    Science.gov (United States)

    2008-03-01

    blood from intestinal mucosal cells (Linder and Hazegh-Azam, 1996:799S). Wilson’s disease is a genetic disorder that causes ineffective copper...mucociliary escalator, is via the trachea and subsequently cleared in the esophagus (Lam, et al., 2004:131). However, various situations exist in which...to motor oil,” Wear, 252(1-2): 63-69 (January 2002). Teeguarden, Justin G., Paul M. Hinderliter, Galya Orr, Brian D. Thrall, and Joel G. Pounds

  5. Contribution à l'étude de la gestion intégrée de la fertilité du sol pour ...

    African Journals Online (AJOL)

    Contribution à l'étude de la gestion intégrée de la fertilité du sol pour la culture de maïs (Zea mays) dans la Région de Mbujimayi, RDC. Michel Nkongolo Mulambuila, Jean Michel Mutombo Tshibamba, Justin Cibanda Mutombo, Pierrot Muka Mulamba, Thèrese Masengu Tshibuyi, Grégoire Tshibangu Kabongo ...

  6. Silicon-Based Examination of Gamma-Ray and Neutron Interactions with Solid State Materials

    Science.gov (United States)

    2018-05-02

    58 1) Mark Hammig, Ass. Research Scientist, Nuclear Engineering and Rad. Sciences (NERS), 30 % effort 2) Justin Sanders, Grad..Stud., Ph.D...Junior (Chemical Engineering ), part-time during school year. 7) Joseph Karbowski, Undergraduate Student, Senior (NERS), full-time in summer, part...scientific collaborations with the leading nanotechnology research groups in the world. Geehyun Kim, the main funded graduate student during most of the

  7. Architecture for people who can manage without it? : 13th Venice Architecture Biennale Common Ground / Triin Ojari

    Index Scriptorium Estoniae

    Ojari, Triin, 1974-

    2012-01-01

    13. Venezia arhitektuuribiennaalist "Ühisosa". Üldkuraator David Chipperfield. Biennaali Kuldlõvi pälvisid Justin McGuirk, Iwan Baan ja Urban-Think Tank (Torre David/Gran Horizonte, Venezuela), Jaapani paviljon (kuraator Toyo Ito). Eesti ekspositsioonist "Kui pikk on ühe maja elu?", mis käsitleb väärika modernismipärandi hääbumist Tallinna Linnahalli näitel

  8. A portable virtual machine target for proof-carrying code

    DEFF Research Database (Denmark)

    Franz, Michael; Chandra, Deepak; Gal, Andreas

    2005-01-01

    Virtual Machines (VMs) and Proof-Carrying Code (PCC) are two techniques that have been used independently to provide safety for (mobile) code. Existing virtual machines, such as the Java VM, have several drawbacks: First, the effort required for safety verification is considerable. Second and mor...... simultaneously providing efficient justin-time compilation and target-machine independence. In particular, our approach reduces the complexity of the required proofs, resulting in fewer proof obligations that need to be discharged at the target machine....

  9. Identity Use and Misuse of Public Persona on Twitter

    OpenAIRE

    Köse, Dicle Berfin; Veijalainen, Jari; Semenov, Alexander

    2016-01-01

    Social media sites have appeared during the last 10 years and their use has exploded all over the world. Twitter is a microblogging service that has currently 320 million user profiles and over 100 million daily active users. Many celebrities and leading politicians have a verified profile on Twitter, including Justin Bieber, president Obama, and the Pope. In this paper we investigate the '‘hundreds of Putins and Obamas phenomenon’ on Twitter. We collected two data sets in 2015 co...

  10. Annotated Bibliography for Lake Erie. Volume II. Chemical,

    Science.gov (United States)

    1974-10-01

    ural forces tending to restore equilibrium. Bieber , Glen F. - See: Frank J. Little, Jr., et al, No. 212. 37. Bird, John. 1966. Our dying waters...research should indicate more definite trends. 207. Leonard, Justin W. 1962. Environmental requirements of Ephemeroptera. In: Clarence M. Tarzwell (Ed... Bieber , Thomas J. Horst and Danley F. Brown. 1973. Possible accelerated eutrophication thresholds in the Great Lakes rela- tive to human population

  11. East African Medical Journal - Vol 86, No 3 (2009)

    African Journals Online (AJOL)

    Anti-diabetic drugs in the private and public sector in Dar es Salaam, Tanzania · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. M Justin-Temu, R.S.O Nondo, K Wiedenmayer, K.L Ramaiya, A Teuscher, 110-114. http://dx.doi.org/10.4314/eamj.v86i3.54962 ...

  12. Analysis of return on investment for Naval air station fallon energy project Alternatives

    Science.gov (United States)

    2017-06-01

    Manager (Justin Sielsch, personal communication ). Lack of in-house skill related to HVAC retrofits would require substantial effort by Public Works ...bill. An ESPC project is financed by the contractor performing the work . The contractor guarantees a certain annual energy savings because of their... work . The Navy installation uses the annual savings from its energy budget to pay back the contractor. ESPCs include contractor performance

  13. Exploring the Relationships Between Just-In-Time Technique and Manufacturing Performance: Empirical Evidence From Selected Nigerian Firms

    OpenAIRE

    Ph. D. John Kolade Obamiro

    2009-01-01

    This study explores the relationship between just-in-time technique and manufacturing performance of some selected Nigerian companies. Just-in time was considered to be an overall organisational phenomenon. Data were obtained through a structured questionnaire from a sample size of 300 knowledgeable employees to test the developed model and formulated hypotheses that cover both just-intime and the supporting infrastructures. Bivariate correlation analysis was used to test the three hypotheses...

  14. Validating a Finite Element Model of a Structure Subjected to Mine Blast with Experimental Modal Analysis

    Science.gov (United States)

    2017-11-01

    Howle, Dmitriy Krayterman, Justin E Pritchett, and Ryan Sorenson 5d. PROJECT NUMBER 5e. TASK NUMBER 5f. WORK UNIT NUMBER 7. PERFORMING...The Under-body Blast Methodology (UBM) for the Test and Evaluation (T&E) program was established to provide a capability for the US Army Test and...and must be validated. The UBM for the T&E program has completed efforts to validate soil models but not structural dynamics models. Modal testing

  15. Siim Nestor soovitab : Wicked Beat. President of Funk. Muuseumiööl. Springz Bashmendil / Siim Nestor

    Index Scriptorium Estoniae

    Nestor, Siim, 1974-

    2002-01-01

    16. mail toimub Emajõe äärses klubis Atlantis Eesti esimene nu-skool breaks õhtu Wicked Beat, kus peaesinejaks on DJ ja produtsent Databass (plaadifirma Freakaboom "juhatuse esimees" Justin Owen). 18. mail house-muusika pidu Tartus muusikagaleriis Damtan Dance. 17. mai ööl Rotermanni soolalaos triod: 1. Riho Sibul, Jaak Sooäär ja Raul Saaremets ning 2. Tõnis Leemets, Robert Jürjendal ja Aivar Tõnso. 17. mail Von Krahlis Dj Dr. Koit

  16. Reforming U.S. Export Controls Reforms: Advancing U.S. Army Interests

    Science.gov (United States)

    2015-12-01

    The author wishes to thank several anonymous and peer re- viewers as well as Alex Barnes, Rachel Bauman, Justin Blaszczyk, William Cardon ...is worth noting in that it requires, pursuant to the Arms Export Control Act, that: certification be provided to Congress prior to the granting of...security. Otherwise, approval cannot be granted until 15 days after Congress has re- ceived the certification for the manufacturing license or technical

  17. Ethics and the Military Profession. Sports and the Military

    Science.gov (United States)

    1980-01-01

    virtues, it would strive for an additional objective you both have chosen to ignore: aesthetic achievement. VICTOR: Uh, oh. H.D. is going to Wax artistic on...HENRY-DAVID: Easy. Think of the events in gymnastics . They require strength, timing, coordination, and endurance; and acquiring the skills demands...aesthetically. What more can you ask of a sport? JUSTIN: But gymnastics is competitive. VICTOR: And it doesn’t really develop team skills. HENRY-DAVID: You’re

  18. Political pugilists: recuperative gender strategies in canadian electoral politics.

    Science.gov (United States)

    Maiolino, Elise

    2015-05-01

    This paper offers the concept recuperative gender strategies to describe how political leaders work to restore their public gender identities. The author examines a charity-boxing match between two Canadian politicians, Justin Trudeau and Patrick Brazeau. Trudeau is the current leader of the Liberal Party of Canada and son of former Prime Minister, Pierre Trudeau. Brazeau was a Conservative Senator. Through a discourse analysis of 222 national newspaper articles published on the match, this paper chronicles Justin Trudeau's transition from "precariously masculine" to "sufficiently masculine" and discusses the significance of this transformation for Trudeau's suitability for Liberal Party leadership. Cet article propose le concept de stratégies de récupération des sexes pour décrire et expliquer comment des dirigeants politiques travaillent à rétablir leurs identités sexuelles publiques. J'analyse la couverture médiatique du combat de boxe caritatif datant de mars 2012 et opposant deux politiciens canadiens : Justin Trudeau, le chef du Parti libéral du Canada, et Patrick Brazeau, un sénateur conservateur. En m'appuyant sur une analyse de discours de 222 articles de journaux nationaux publiés au sujet de ce combat, je détaille la transition de Justin Trudeau d'une forme de masculinité « précaire » à une « masculinité suffisante », et je discute de l'importance de cette transformation pour l'aptitude perçue de Trudeau comme chef du Parti libéral. © 2015 Canadian Sociological Association/La Société canadienne de sociologie.

  19. Northwest Manufacturing Initiative

    Science.gov (United States)

    2012-03-27

    HRC 60 were obtained . UIT also changed the ESD induced residual stress distribution from about +100ksi to - 250ksi. This compressive stress extended...Staff. Justin Jangraw profiled PNDC companies. In addition to directly creating profiles, Navindra focused on obtaining lists of companies from...NW Connectory to source parts for their Biogas Filtration systems. • Connected with Vigor Industrial . • Resulted in $750,000 and 10 new Portland

  20. Justice in the Air: Tracking Toxic Pollution from America's Industries and Companies to Our States, Cities, and Neighborhoods

    OpenAIRE

    Michael Ash; James Boyce; Grace Chang; Justin Scoggins; Manuel Pastor

    2009-01-01

    This new environmental justice study, (co-authored by PERI’s James Boyce, Michael Ash, & Grace Chang, along with Manuel Pastor, Justin Scoggins, & Jennifer Tran of the Program for Environmental and Regional Equity at the University of Southern California) examines not only who receives the disproportionate share of toxic air releases -- low-income communities and people of color -- but who is releasing them. Justice in the Air: Tracking Toxic Pollution from America's Industries and Companies ...

  1. Browse Author Index

    African Journals Online (AJOL)

    Items 1 - 47 of 47 ... Ikhuoria, E.U. · Ikiz, Serkan · Ikram, Muhammad · Ikram, Muhammad · Ilomo, O. O. · Ilomo, O.O. · Ilukhor, P.E.P. · Imanieh, Hossein · Imeokparia, F.E. · Imran, M. Inayat, M. Ipinmoroti, K.O. · Iqbal, M. Iqbal Choudhary, M. Iqbal Choudhary, Muhammad · Iranmanesh, P. Irfan, A. Irfan, A. Irina, Justin · Isabirye, D.A.

  2. [The psychosocial challenges of epilepsy and the role of the clinical nurse specialist].

    Science.gov (United States)

    Chartrand, Dominic

    2015-01-01

    Epilepsy in children is a complex disease with significant psychosocial consequences for the child and their family. The intervention of a multidisciplinary team enables the care to be adapted and provides support for the families. At Sainte-Justine Hospital in Montreal, Canada, the nurse clinician specialised in epilepsy plays a key role in this team. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  3. A Lean Six Sigma Analysis of Student In-Processing

    Science.gov (United States)

    2012-12-01

    improvements. 4. Lt Justin Whipple : NPS Student Services representative, primary stakeholder and key source of implementation and control. xvi THIS...Internet connections took over a week. The entire move process took two weeks and had to be scheduled around required check-in procedures . CPT Johnson...processing procedure which represents, as such, a very important stakeholder. They are, however, a type 4 mixed blessing stakeholder. Although they

  4. National security and the impact of cyber threats on the average citizen

    CSIR Research Space (South Africa)

    Jansen van Vuuren, JC

    2010-09-01

    Full Text Available LinkedIn account Work information Company name Intecon Occupation Programmer Colleagues Trevor Mohasoa ? Help desk Marista Conradie ? Receptionist and Personal Assistant Personal information Email address and username/alias einad5@gmail....com Contacts Stephen Swart Justin Booth Ivan Burke Francois Joubert Nicolaas Strecker Hanno Combrink Data gathered from Google profile and gmail email address ? Information gathered from Google Buzz account ? Operating System preference (complains...

  5. Cost analysis of consolidated federally provided health care

    Science.gov (United States)

    2017-06-01

    Government Accountability Office JIT just-in time KPO Kaizen promotion offices LT lead time MHS Military Health System MRI magnetic resonance...a hospital that is only large enough for one MRI unit may need to hold it idle much of the time to permit emergency testing; whereas, a hospital...Center San Diego and San Diego VA hospital both provide outpatient pharmaceutical services. Duplication and redundancy of operating two separate

  6. Spræng boblen

    DEFF Research Database (Denmark)

    Hendricks, Vincent Fella

    Hvad har en dansk Justin Bieber look-a-like, Dovne Robert og frokostfrikadeller – eller mangel på samme – i landets børnehaver til fælles? De kan forstås og forklares med bobleteori. Bortset fra de af slagsen, der laves af sæbe eller findes i champagne, forbindes bobler typisk med situationer i...

  7. Aproximación al estudio de los discursos en el epítome de Justino

    OpenAIRE

    Ballesteros Pastor, Luis

    2009-01-01

    Justin’s Epitome records some speeches that Trogus had included in the Historiae Philippicae . Justin abridges and modifies a great deal of these passages, which appear in most cases in oratio obliqua, following an option that he attributes to Trogus. Justin’s manipulation of the text makes these discourses very problematic to study: sometimes they are extremely shortened, or they completely lack any kind of settings, or they are moved from their original place, or they may even appear in dir...

  8. STS-59 crewmembers in training for onboard Earth observations

    Science.gov (United States)

    1993-01-01

    The six astronauts in training for the STS-59 mission are shown onboard Earth observations tips by Justin Wilkinson (standing, foreground) of the Space Shuttle Earth Observations Project (SSEOP) group. Astronaut Sidney M. Gutierrez, mission commander, is at center on the left side of the table. Others, left to right, are Astronauts Kevin P. Chilton, pilot; Jerome (Jay) Apt and Michael R.U. (Rich) Clifford, both mission specialists; Linda M. Godwin, payload commander; and Thomas D. Jones, mission specialist.

  9. Pharmacological Characterization of 5-Substituted 1-[(2,3-dihydro-1-benzofuran-2-ylmethyl]piperazines: Novel Antagonists for the Histamine H3 and H4 Receptors with Anti-inflammatory Potential

    Directory of Open Access Journals (Sweden)

    Michelle F. Corrêa

    2017-11-01

    Full Text Available The histamine receptors (HRs are traditional G protein-coupled receptors of extensive therapeutic interest. Recently, H3R and H4R subtypes have been targeted in drug discovery projects for inflammation, asthma, pain, cancer, Parkinson’s, and Alzheimer’s diseases, which includes searches for dual acting H3R/H4R ligands. In the present work, nine 1-[(2,3-dihydro-1-benzofuran-2-ylmethyl]piperazine (LINS01 series molecules were synthesized and evaluated as H3R and H4R ligands. Our data show that the N-allyl-substituted compound LINS01004 bears the highest affinity for H3R (pKi 6.40, while the chlorinated compound LINS01007 has moderate affinity for H4R (pKi 6.06. In addition, BRET assays to assess the functional activity of Gi1 coupling indicate that all compounds have no intrinsic activity and act as antagonists of these receptors. Drug-likeness assessment indicated these molecules are promising leads for further improvements. In vivo evaluation of compounds LINS01005 and LINS01007 in a mouse model of asthma showed a better anti-inflammatory activity of LINS01007 (3 g/kg than the previously tested compound LINS01005. This is the first report with functional data of these compounds in HRs, and our results also show the potential of their applications as anti-inflammatory.

  10. Production and characterization of nanocapsules encapsulated linalool by ionic gelation method using chitosan as wall material

    Directory of Open Access Journals (Sweden)

    Zuobing XIAO

    Full Text Available Abstract Linalool has been extensively applied in various fields, such as flavoring agent, perfumes, cosmetics and medical science. However, linalool is unstable, volatile and readily oxidizable. A sensitive substance can be encapsulated in a capsule, so encapsulation technology can solve these problems. In this paper, linalool-loaded nanocapsules (Lin-nanocapsules were prepared via the ionic gelation method and Lin-nanocapsules were characterized. The results of Fourier transformation infrared spectroscopy (FTIR showed that linalool was successfully encapsulated in the wall materials. Scanning electron microscopy (SEM results demonstrated that the shapes of Lin-nanocapsules, with smooth surfaces, were nearly spherical. Lin-nanocapsule average particle size was 352 nm and its polydispersity index (PDI was proved to be 0.214 by the results of dynamic light scattering (DLC. Thermogravimetric results indicated that linalool loading capacity (LC was 15.17%, and encapsulation could decrease linalool release and increase linalool retaining time under the high temperature. Oscillatory shear and steady-state shear measurements of Lin-nanocapsule emulsions were systematically investigated. The results of steady-state shear showed that Lin-nanocapsule emulsion, which was Newtonian only for high shear rate, was non-Newtonian. It was proved by oscillatory shear that when oscillation frequency changed from low to high, Lin-nanocapsules emulsion changed from viscous into elastic.

  11. Smart Methods for Linezolid Determination in the Presence of Alkaline and Oxidative Degradation Products Utilizing Their Overlapped Spectral Bands

    Science.gov (United States)

    Abd El-Monem Hegazy, M.; Shaaban Eissa, M.; Abd El-Sattar, O. I.; Abd El-Kawy, M. M.

    2014-09-01

    Linezolid (LIN) is considered the first available oxazolidinone antibacterial agent. It is susceptible to hydrolysis and oxidation. Five simple, accurate, sensitive and validated UV spectrophotometric methods were developed for LIN determination in the presence of its alkaline (ALK) and oxidative (OXD) degradation products in bulk powder and pharmaceutical formulation. Method A is a second derivative one (D2) in which LIN is determined at 240.9 nm. Method B is a pH-induced differential derivative one where LIN is determined using the fourth derivative (D4) of the difference spectra (ΔA) at 285.3 nm. Methods C, D, and E are manipulating ratio spectra, where C is the double divisor-ratio difference spectrophotometric one (DD-RD) in which LIN was determined by calculating the amplitude difference at 243.7 and 267.6 nm of the ratio spectra. Method D is the double divisor-first derivative of ratio spectra (DD-DD1) in which LIN was determined at 270.2 nm. Method E is a mean centering of ratio spectra one (MCR) in which LIN was determined at 318.0 nm. The developed methods have been validated according to ICH guidelines. The results were statistically compared to that of a reported HPLC method and there was no significant difference regarding both accuracy and precision.

  12. Essential Oil of Ocimum basilicum L. and (−-Linalool Blocks the Excitability of Rat Sciatic Nerve

    Directory of Open Access Journals (Sweden)

    Antonio Medeiros Venancio

    2016-01-01

    Full Text Available The racemate linalool and its levogyrus enantiomer [(−-LIN] are present in many essential oils and possess several pharmacological activities, such as antinociceptive and anti-inflammatory. In this work, the effects of essential oil obtained from the cultivation of the Ocimum basilicum L. (EOOb derived from Germplasm Bank rich in (−-LIN content in the excitability of peripheral nervous system were studied. We used rat sciatic nerve to investigate the EOOb and (−-LIN effects on neuron excitability and the extracellular recording technique was used to register the compound action potential (CAP. EOOb and (−-LIN blocked the CAP in a concentration-dependent way and these effects were reversible after washout. EOOb blocked positive amplitude of 1st and 2nd CAP components with IC50 of 0.38±0.2 and 0.17±0.0 mg/mL, respectively. For (−-LIN, these values were 0.23±0.0 and 0.13±0.0 mg/mL. Both components reduced the conduction velocity of CAP and the 2nd component seems to be more affected than the 1st component. In conclusion EOOb and (−-LIN inhibited the excitability of peripheral nervous system in a similar way and potency, revealing that the effects of EOOb on excitability are due to the presence of (−-LIN in the essential oil.

  13. In reactor measurements, modeling and assessments to predict liquid injection shutdown system nozzle to Calandria tube time to contact

    International Nuclear Information System (INIS)

    Kirstein, K.; Kalenchuk, D.

    2011-01-01

    Over the past few years there has been an expanding effort to assess the potential for Calandria Tubes (CTs) coming into contact with Liquid Injection Shutdown System (LISS) Nozzles to ensure continued contact-free operation as required by CSA N285.4. LISS Nozzles (LINs), which run perpendicular to and between rows of fuel channels, sag at a slower rate than the fuel channels. As a result certain LINs may come in contact with CTs above them. The CT/LIN gaps can be predicted from calculated CT sag, LIN sag and a number of component and installation tolerances. This method however results in very conservative predictions when compared to measurements, confirmed with the in reactor measurements initiated in 2000, when gaps were successfully measured the first time using images obtained from a camera-assisted measurement tool inserted into the calandria. To reduce the conservatism of the CT/LIN gap predictions, statistical CT/LIN gap models are used instead. They are derived from a comparison between calculated gaps based on nominal dimensions and the visual image based measured gaps. These reactor specific (typically 95% confidence level) CT/LIN gap models account for all uncertainties and deviations from nominal values. Prediction error margins reduce as more in-reactor gap measurements become available. Each year more measurements are being made using this standardized visual CT/LIN proximity method. The subsequently prepared reactor-specific models have been used to provide time to contact for every channel above the LINs at these stations. In a number of cases it has been used to demonstrate that the reactor can be operated to its end of life before refurbishment with no predicted contact, or specific at-risk channels have been identified for which appropriate remedial actions could be implemented in a planned manner. (author)

  14. “O CAÇADOR”, DE RINALDO DE FERNANDES: O VIVER O JOGO E A EXPERIÊNCIA URBANA DA OCUPAÇÃO / “The hunter”, by Rinaldo de Fernandes: to live the game and the urban experience of the occupation

    Directory of Open Access Journals (Sweden)

    Márcia Manir Miguel Feitosa

    2016-01-01

    Full Text Available Objetiva-se com esse artigo uma leitura da espacialidade no conto “O caçador”, de Rinaldo deFernandes, considerado um dos grandes expoentes da literatura brasileira contemporânea. Emfunção da dinâmica da ação transcorrida no universo da casa do caçador, um dos personagensprincipais do conto, constituirá o leitmotiv deste texto o constructo da experiência urbana da ocupação.Como aporte teórico serão suscitadas as obras O homem e a terra: natureza da realidadegeográfica, do geógrafo francês Eric Dardel; A poética do espaço, do filósofo francês GastonBachelard e, sobretudo, Topofilia: um estudo da percepção, atitudes e valores do meio ambienteespaço e lugar: a perspectiva da experiência, ambas de autoria do geógrafo chinês Yi-Fu Tuan.À luz, portanto, da teoria da percepção do espaço sob o viés fenomenológico-existencialista, seráanalisado o conto em tela numa perspectiva interdisciplinar, mais especificamente da GeografiaHumanista Cultural, um dos campos mais instigantes da Geografia contemporânea, onde a subjetividadepode ser incorporada para fins de estudo e interpretação da condição humana. Palavras-chave: espaço; experiência; ocupação.

  15. Theoretical studies of the global minima and polarizabilities of small lithium clusters

    Energy Technology Data Exchange (ETDEWEB)

    Hu, Hanshi; Zhao, Ya-Fan; Hammond, Jeffrey R.; Bylaska, Eric J.; Apra, Edoardo; van Dam, Hubertus JJ; Li, Jun; Govind, Niranjan; Kowalski, Karol

    2016-01-16

    Lithium clusters Lin (n=1-20) have been investigated with density functional theory (DFT) and coupled—cluster (CC) methods. The global-minimum structures are located via an improved basin---hopping algorithm and the lowest energy Lin isomers are confirmed with DFT geometry optimizations, CCSD(T) energy calculations, and by comparing simulated and experimental polarizabilities. The tetrahedral Li4 structure is found to be the basic building block of lithium clusters Lin (n=6-20). Simulated polarizabilities, including thermal effects at room temperature, are in good agreement with measured isotropic polarizabilities.

  16. Three new species of Begonia (Begoniaceae from Limestone Hills in southwestern Sarawak, Borneo

    Directory of Open Access Journals (Sweden)

    Che-Wei Lin

    2017-04-01

    Full Text Available Most species of Begonia in Borneo, like those of other areas, are narrowly distributed and site-specific. In this study we report three new species of Begonia, namely B. felis C. W. Lin & C.-I Peng, B. kuchingensis C. W. Lin & C.-I Peng (sect. Petermannia and B. serianensis C. W. Lin & C.-I Peng (sect. Reichenheimia from the Padawan-Serian limestone hills in southwestern Sarawak. In addition to the taxonomic account, color plates, line drawings, a distribution map, and comparisons with phenetically similar species are provided to aid in identification.

  17. Verification and Validation of the Coastal Modeling System. Report 1: Summary Report

    Science.gov (United States)

    2011-12-01

    Center, Coastal and Hydraulics Laboratory, Vicksburg, MS. Li, H., L. Lin, C. Lu and A.T. Shak . 2011 (In press). Evaluation of Breakwaters and...cirp.usace.army.mil/pubs/html/09-Li-Brown_TR-09-19.html, accessed 7 June 2011. Li, H., L. Lin, C. Lu andA.T. Shak . 2011 In press. Evaluation of Breakwaters and...TR-11-10 87 Reference: Li, H., L. Lin, C. Lu and A.T. Shak . 2011. Evaluation of Breakwaters and Sedimentation at Dana Point Harbor, CA

  18. Diamond lemma for the group graded quasi-algebras

    Indian Academy of Sciences (India)

    Author Affiliations. MAMTA BALODI1 HUA-LIN HUANG2 SHIV DATT KUMAR1. Department of Mathematics, Motilal Nehru National Institute of Technology, Allahabad 211 004, India; School of Mathematics, Shandong University, Jinan 250100, China ...

  19. The Genetic Structure of Milkfish (Chanos chanos) Stocks from ...

    African Journals Online (AJOL)

    Yudha T Adiputra

    2012-02-14

    Feb 14, 2012 ... Genetic diversity of Indonesia milkfish (Chanos chanos) using amplified ... into fish populations in a wide range of applications. (Verspoor ... The quality of extracted DNA was ..... egg, larval and adult stages (Lin et al., 2009).

  20. Dicty_cDB: Contig-U12032-1 [Dicty_cDB

    Lifescience Database Archive (English)

    Full Text Available iviii*fyn*kkdqk ielvvllicivil*gdnnkl*iinyk**iinnnnk*yyi*kikf*k*ikk Frame C: lin**...l *lksil*tqi*knntlnwvvywvkv*cf*ihqpidnvkp*pyqsienlvplknvaksvvi lmncyiiyiilivvvpiilv*nvqskk*plis*iifkdlgqitsl

  1. African Journal of Biotechnology - Vol 12, No 31 (2013)

    African Journals Online (AJOL)

    induced fatty liver model of consecutive extracts from Rosa davurica Pall · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Ying Wei, Muyi Cai, Ruizeng Gu, Jun Lu, Feng Lin, Baoping Ji ...

  2. Prevalence of clinical benign prostatic hyperplasia amongst ...

    African Journals Online (AJOL)

    R.W. Ojewola

    2017-04-29

    Apr 29, 2017 ... Subjects and methods: This is a community-based cross-sectional survey conducted ... and BPH among countries, possibly arising from cultural or lin- ..... reported prevalence 21.0% in Jeju Island, South Korea [5] and of.

  3. Quick insulin radioimmunoassay and its utilization for intra operative localization of insulinoma

    International Nuclear Information System (INIS)

    Ursich, M.J.M.; Fukui, R.T.; Aguiar Pupo, A. de; Machado, M.C.C.

    1988-01-01

    A quick insuLin radioimmunoassay performed in 90 minutes is described and the results are compared with those obtained with the conventional method. The realibility of the new procedure is pointed. (M.A.C.) [pt

  4. Remediation of Aqueous Solution of Cypermethrin and ...

    African Journals Online (AJOL)

    ADOWIE PERE

    Curcas can be effective in the adsorption of these two pesticides from water bodies. Equilibrium experiment results ... and electro-Fenton , combined ultrasound and Fenton. (Ma et al, 2010), ..... Desalination, 250, 450-455 492. Chang, K; Lin, J ...

  5. Hans-Dieter Kreuder. Metasprachliche Lexikographie ...

    African Journals Online (AJOL)

    rbr

    Kreuder's study specifically describes the history and development of lin- .... the First International Linguistic Conference in The Hague in 1928, this effort of linguists to ..... rules and good communication to ensure consistent treatment of the.

  6. Culture as a Probiotic

    African Journals Online (AJOL)

    pc

    2012-04-12

    Apr 12, 2012 ... effects of kefir were studied on human beings (Lin and. Change, 2000; Hoolihan, 2001; ... composition, reduced malformations and improved gut morphology and ..... Disinfection of Gilthead Sea Bream. (Sparus aurata), Red ...

  7. Journal of Biosciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    De Tian1 Lin Guo1. Orthopedics Department, Hospital of Dalian University, Dalian 116 001, China; School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang, China; The Nursing Department, Affiliated Zhongshan ...

  8. Trochanteric bursitis

    Science.gov (United States)

    ... of the hip; Hip bursitis References Fredericson M, Lin C, Chew K. Greater trochanteric pain syndrome. In: ... Shoulder Service, UCSF Department of Orthopaedic Surgery, San Francisco, CA. Also reviewed by David Zieve, MD, MHA, ...

  9. Government Expenditure, Efficiency and Economic Growth: A Panel ...

    African Journals Online (AJOL)

    Choong Chee Keong. 6 and Lau Lin Sea. 7 ... Corresponding Author, Department of Economics, Faculty of Business and Finance, UTAR, Malaysia. .... the taxation system and assert that if country's government expenditure is greater than.

  10. Näitus "Eesti kirjanik karikatuuris" = Exhibition "Estonian writers in caricature"

    Index Scriptorium Estoniae

    2011-01-01

    linäitus pälvis Eesti Sisearhitektide Liidu 2010. a. näituse ja installatsiooni kujunduse preemia. Autorid: Kaarel Vahtramäe, Liina Jakobson, Mart Lankots, Janno Siimar (Velvet Creative Alliance)

  11. Outdoor fitness routine

    Science.gov (United States)

    ... on a sport you enjoy, such as bicycling, hiking, jogging, rowing, tennis, or Frisbee. Make chores a ... L, Lin BB, Gaston KJ, Fuller RA. The benefits of natural environments for physical activity. Sports Med . ...

  12. Proceedings – Mathematical Sciences | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Wenhua Gao1 Lin Tang2. School of Applied Mathematics, Beijing Normal University Zhuhai, Zhuhai 519085, People's Republic of China; LMAM, School of Mathematical Sciences, Peking University, Beijing 100871, People's Republic of China ...

  13. African Journal of Biotechnology - Vol 11, No 69 (2012)

    African Journals Online (AJOL)

    In silico comparative analysis of EST-SSRs in three cotton genomes · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Daojun Yuan, Shaoguang Liang, Zhongxu Lin, Xianlong Zhang, 13269-13371 ...

  14. ORIGINAL ARTICLE

    African Journals Online (AJOL)

    TB which relies heavily on culture and phenotypic. DST are ... strains from East Asian Lineage and Beijing sub lin- eage acquire DR ...... Indian Journal of Chest Diseases & Allied Sci- ence ... Southeast Asian Journal of Tropical Medicine and.

  15. Survey of Internet Use as a Source of Health-Related Information in ...

    African Journals Online (AJOL)

    relationship between Internet use and socio-demographic variables. ... the effect of socio-demographic variables on. Internet use. ... Statistical Package for Social Science. (SPSS .... Lin CA. Perceived Gratifications of Online Media Services.

  16. Pramana – Journal of Physics | Indian Academy of Sciences

    Indian Academy of Sciences (India)

    Author Affiliations. Yang Xian-Lin1 2 Tang Jia-Shi1. College of Mechanics and Aerospace, Hunan University, Changsha, Hunan 410082, China; Hunan Radio and Television University, Changsha, Hunan 410004, China ...

  17. Surface Turbulent Fluxes, 1x1 deg Monthly Climatology, Set1 and NCEP V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  18. Surface Turbulent Fluxes, 1x1 deg Yearly Climatology, Set1 and NCEP V2c (GSSTFYC) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  19. Surface Turbulent Fluxes, 1x1 deg Monthly Climatology, Set1 and NCEP V2c (GSSTFMC) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  20. Surface Turbulent Fluxes, 1x1 deg Monthly Grid, Set1 and Interpolated Data V2c (GSSTFM) at GES DISC

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  1. Surface Turbulent Fluxes, 1x1 deg Monthly Grid, Set1 and Interpolated Data V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  2. Surface Turbulent Fluxes, 1x1 deg Yearly Climatology, Set1 and NCEP V2c

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-2c Dataset recently produced through a MEaSURES funded project led by Dr. Chung-Lin Shie...

  3. Young Children's Mathematics References during Free Play in Family Childcare Settings

    Science.gov (United States)

    Hendershot, Shawnee M.; Berghout Austin, Ann M.; Blevins-Knabe, Belinda; Ota, Carrie

    2016-01-01

    Very little is known about children's discussion of mathematics topics during unstructured play. Ginsburg, Lin, Ness, and Seo [2003. Young American and Chinese children's everyday mathematical activity. Mathematical Thinking and Learning, 5(4), 235-258. Retrieved from…

  4. Generic UAV Modeling to Obtain Its Aerodynamic and Control Derivatives

    National Research Council Canada - National Science Library

    Chua, Choon S

    2008-01-01

    .... The first approach explored in this thesis involves using the LinAir software program developed about a decade ago at Stanford University, the second one relies on the Athena Vortex Lattice package...

  5. Use of shell model calculations in R-matrix studies of neutron-induced reactions

    International Nuclear Information System (INIS)

    Knox, H.D.

    1986-01-01

    R-matrix analyses of neutron-induced reactions for many of the lightest p-shell nuclei are difficult due to a lack of distinct resonance structure in the reaction cross sections. Initial values for the required R-matrix parameters, E,sub(lambda) and γsub(lambdac) for states in the compound system, can be obtained from shell model calculations. In the present work, the results of recent shell model calculations for the lithium isotopes have been used in R-matrix analyses of 6 Li+n and 7 Li+n reactions for E sub(n) 7 Li and 8 Li on the 6 Li+n and 7 Li+n reaction mechanisms and cross sections are discussed. (author)

  6. 76 FR 554 - Ocean Transportation Intermediary License Applicants

    Science.gov (United States)

    2011-01-05

    ... Western Way, Torrance, CA 90501. Officer: Hseanru aka Stephen H. Lin, President/VP/Secretary/CFO... Street, Lyndhurst, NJ 07071. Officers: Jerry Wang, Vice President (Qualifying Individual), Loong H. Chang...

  7. Unedited Version

    Indian Academy of Sciences (India)

    5

    Patient with Familial Norrie Disease: Bilateral Blindness and Leucocoria ..... Lin RC, Shih JC (2013) Monoamine oxidase A and A/B knockout mice display autistic-like ... spectrum in familial exudative vitreoretinopathy and Norrie disease with ...

  8. Festivalivaip läks Hiinasse / Anu Saare

    Index Scriptorium Estoniae

    Saare, Anu, 1964-

    2000-01-01

    Neljateistkümnenda Pärnu rahvusvahelise dokumentaal- ja antropoloogiafilmide festivalil peaauhinna saanud hiinlase Pu Lin Wen'i filmist "Otsides Shangri La'd". Ka teistest auhinnatud filmidest ning nende nimekiri

  9. CrossTalk: The Journal of Defense Software Engineering. Volume 21, Number 9

    National Research Council Canada - National Science Library

    Cook, Steve; Lin, Calvin; Chang, Walter; Hansson, Joergen; Feiler, Peter H; Morley, John; Howard, Michael; Pal, Partha; Atighetchi, Michael; Goertzel, Karen M; Cunha, Corey P

    2008-01-01

    .... Calvin Lin, and Walter Chang: Describes an extensible, compiler-based system to ensure that C programs enforce a wide variety of user-defined security policies with a minimum of runtime overhead and disruption to development processes. 2...

  10. 76 FR 76411 - Ocean Transportation Intermediary License; Applicants

    Science.gov (United States)

    2011-12-07

    ... Avenue, Apt. A, Monterey Park, CA 91755-2044, Officers: Li Lin, General Manager/Sec/CFO, (Qualifying.... Suddath Global Logistics, LLC dba Suddath Global Logistics, (NVO & OFF), 815 South Main Street...

  11. Generalized Extreme Value model with Cyclic Covariate Structure ...

    Indian Academy of Sciences (India)

    48

    enhances the estimation of the return period; however, its application is ...... Cohn T A and Lins H F 2005 Nature's style: Naturally trendy; GEOPHYSICAL ..... Final non-stationary GEV models with covariate structures shortlisted based on.

  12. Goddard Satellite-Based Surface Turbulent Fluxes Climatology, Yearly Grid V3

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-3 Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  13. Goddard Satellite-Based Surface Turbulent Fluxes Climatology, Seasonal Grid V3

    Data.gov (United States)

    National Aeronautics and Space Administration — These data are the Goddard Satellite-based Surface Turbulent Fluxes Version-3 Dataset recently produced through a MEaSUREs funded project led by Dr. Chung-Lin Shie...

  14. The sounds of Chinese and how to teach them

    Czech Academy of Sciences Publication Activity Database

    Třísková, Hana

    2008-01-01

    Roč. 76, č. 4 (2008), s. 509-544 ISSN 0044-8699 Institutional research plan: CEZ:AV0Z90210515 Keywords : Mandarin * phonetics * phonology * teaching * pronunciation * Yen-Hwei Lin Subject RIV: AI - Linguistics

  15. SELES

    DEFF Research Database (Denmark)

    Garcia-Zamora, Claudia; Rodriguez-Henriquez, Francisco; Ortiz-Arroyo, Daniel

    2005-01-01

    In this paper we present an improved e-voting protocol for online elections based on the scheme proposed by Lin--Hwang--Chang. We show that Lin--Hwang--Chang's scheme has two important weaknesses. We describe in detail our findings and propose a new scheme to overcome these weaknesses effectively....... To test our protocol, we implemented a distributed e-voting system. Finally we evaluate and compare our protocol with other previously proposed schemes....

  16. Protecting Networks Via Automated Defense of Cyber Systems

    Science.gov (United States)

    2016-09-01

    gray-hats/. 61 Hu, Youfan, Yan Zhang, Chen Xu, Long Lin, Robert L. Snyder, and Zhong Lin Wang. “Self-Powered System with Wireless Data Transmission ...wires will almost completely cease to exist, replaced by mobile nanodevices, which are tiny computers measured in nanometers with integrated wireless ... energy companies, was hypothesized to cost $10,000. Raiu went on to opine, “The cost of entry for [advanced persistent threats] is decreasing …. We’re

  17. Production of 48V in a nuclear reactor via secondary tritons

    International Nuclear Information System (INIS)

    Siri, S.; Cohen, I.M.

    2009-01-01

    The production of 48 V in a nuclear reactor, induced on titanium by tritons generated from the 6 Li(n, t) 4 He reaction, and eventually 7 Li(n, n't) 4 He, is described. Samples of lithium titanate were irradiated for an irradiation cycle (120 h) in the RA-3 reactor, belonging to Ezeiza Atomic Centre. After a radiochemical separation, the characteristic radiations from 48 V were identified in the gamma ray spectra of the vanadium fractions. (orig.)

  18. Algorithms for Large-Scale Astronomical Problems

    Science.gov (United States)

    2013-08-01

    Magana, Ross O’Connell, Xiaoying Xu, and Feng Yu . They are very nice and provided a lot of useful information. During these years I have worked with...Sicun Gao, Fan Guo, Yunchuan Kong, Ni Lao, Lei Li, Nan Li, Jialiu Lin, Yuefeng Lin, Xi Liu, Ning Lu, Min Luo, Kai Ren, Chao Shen, Long Qin, Huimin... Hsieh , Deborah A. Wallach, Mike Burrows, Tushar Chandra, Andrew Fikes, and Robert E. Gruber. Bigtable: A distributed storage system for structured data

  19. Unbiased Combinatorial Genomic Approaches to Identify Alternative Therapeutic Targets within the TSC Signaling Network

    Science.gov (United States)

    2015-09-01

    endonuclease. Nat Biotechnol. 2013;31(3):230-2. Cong L, Ran FA, Cox D, Lin S, Barretto R, Habib N, et al. Multiplex genome engineering using CRISPR/Cas systems...Res 42, e89 (2014)10.1093/nar/gku289). 13. L. Cong, F. A. Ran, D. Cox, S. Lin, R. Barretto, N. Habib , P. D. Hsu, X. Wu, W. Jiang, L. A. Marraffini

  20. RLE (Research Laboratory of Electronics) Progress Report Number 130

    Science.gov (United States)

    1988-07-01

    Ippen, James G. Fujimoto, Wei-Zhu Lin, Beat Zysset, Robert W. Schoenlein, 4 Michael J. Lagasse The investigation of transient carrier dynamics in GaAs...G. Fujimoto, Wei-Zhu Lin, Reginald Birngruber, Beat Zysset, Robert W. Schoenleln Working in collaboration with researchers at the Massachusetts Eye... Binaural Hearing National Institutes of Health (Grant 5 RO 1 NS 10916) H. Steven Colburn, Nathaniel 1. Durlach, Patrick M. Zurek 17 Brooklyn College14 141

  1. Impulse Response of the Exchange Rate Volatility to a Foreign Exchange Intervention Shock

    OpenAIRE

    Hoshikawa, Takeshi

    2009-01-01

    This paper uses Lin's technique (1997) to report on the impulse response function analysis that traces the dynamics of exchange rate volatility from innovations in Japanese foreign exchange intervention. Using a multivariate GARCH model, we employed a volatility impulse response function based on Lin (1997) to detect the impulse response of exchange rate volatility on a one-unit foreign exchange intervention shock. The main findings of t his paper are as follows: (1) a foreign exchange inter...

  2. Classifying chemical mode of action using gene networks and machine learning: a case study with the herbicide linuron.

    Science.gov (United States)

    Ornostay, Anna; Cowie, Andrew M; Hindle, Matthew; Baker, Christopher J O; Martyniuk, Christopher J

    2013-12-01

    The herbicide linuron (LIN) is an endocrine disruptor with an anti-androgenic mode of action. The objectives of this study were to (1) improve knowledge of androgen and anti-androgen signaling in the teleostean ovary and to (2) assess the ability of gene networks and machine learning to classify LIN as an anti-androgen using transcriptomic data. Ovarian explants from vitellogenic fathead minnows (FHMs) were exposed to three concentrations of either 5α-dihydrotestosterone (DHT), flutamide (FLUT), or LIN for 12h. Ovaries exposed to DHT showed a significant increase in 17β-estradiol (E2) production while FLUT and LIN had no effect on E2. To improve understanding of androgen receptor signaling in the ovary, a reciprocal gene expression network was constructed for DHT and FLUT using pathway analysis and these data suggested that steroid metabolism, translation, and DNA replication are processes regulated through AR signaling in the ovary. Sub-network enrichment analysis revealed that FLUT and LIN shared more regulated gene networks in common compared to DHT. Using transcriptomic datasets from different fish species, machine learning algorithms classified LIN successfully with other anti-androgens. This study advances knowledge regarding molecular signaling cascades in the ovary that are responsive to androgens and anti-androgens and provides proof of concept that gene network analysis and machine learning can classify priority chemicals using experimental transcriptomic data collected from different fish species. © 2013.

  3. Population structure and biological characteristics of Siriella gracilis (Mysida) from the Exclusive Economic Zone of India

    Digital Repository Service at National Institute of Oceanography (India)

    Biju, A.; Honey, U.K.; Kusum, K.K.; Jagadeesan, L.

    di ffe re nt se as o n s St at io n n o . La tit ud e (°N ) Lo ng itu de (°E ) IM S (20 04 ) SW M (20 05 ) N EM (20 06 ) S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity... 04 ) SW M (20 05 ) N EM (20 06 ) S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity S. gr a ci lis Te m pe ra tu re Sa lin ity de ns ity (°C ) de ns ity (°C ) de ns ity (°C ) 27 15 72 – 29 .7 35 .0 – 30 .7 35 .9...

  4. A mutation in a coproporphyrinogen III oxidase gene confers growth inhibition, enhanced powdery mildew resistance and powdery mildew-induced cell death in Arabidopsis.

    Science.gov (United States)

    Guo, Chuan-yu; Wu, Guang-heng; Xing, Jin; Li, Wen-qi; Tang, Ding-zhong; Cui, Bai-ming

    2013-05-01

    A gene encoding a coproporphyrinogen III oxidase mediates disease resistance in plants by the salicylic acid pathway. A number of genes that regulate powdery mildew resistance have been identified in Arabidopsis, such as ENHANCED DISEASE RESISTANCE 1 to 3 (EDR1 to 3). To further study the molecular interactions between the powdery mildew pathogen and Arabidopsis, we isolated and characterized a mutant that exhibited enhanced resistance to powdery mildew. The mutant also showed dramatic powdery mildew-induced cell death as well as growth defects and early senescence in the absence of pathogens. We identified the affected gene by map-based cloning and found that the gene encodes a coproporphyrinogen III oxidase, a key enzyme in the tetrapyrrole biosynthesis pathway, previously known as LESION INITIATION 2 (LIN2). Therefore, we designated the mutant lin2-2. Further studies revealed that the lin2-2 mutant also displayed enhanced resistance to Hyaloperonospora arabidopsidis (H.a.) Noco2. Genetic analysis showed that the lin2-2-mediated disease resistance and spontaneous cell death were dependent on PHYTOALEXIN DEFICIENT 4 (PAD4), SALICYLIC ACID INDUCTION-DEFICIENT 2 (SID2), and NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1 (NPR1), which are all involved in salicylic acid signaling. Furthermore, the relative expression levels of defense-related genes were induced after powdery mildew infection in the lin2-2 mutant. These data indicated that LIN2 plays an important role in cell death control and defense responses in plants.

  5. Electromagnetic analysis of ITER generic equatorial port plug designs during three plasma current disruption cases

    International Nuclear Information System (INIS)

    Guirao, J.; Rodríguez, E.; Ordieres, J.; Cabanas, M.F.; García, C.H. Rojas

    2012-01-01

    Highlights: ► Electromagnetic transient performance evaluation of the GEPP structure. ► Three different plasma current disruption cases: MD UP LIN36, VDE UP LIN36 and VDE DW LIN36 were analyzed. ► Three DSM-First Wall (FW) designs (horizontal and vertical drawers and monoblock) were compared. - Abstract: Electromagnetic phenomena due to plasma current disruptions are the cause for the main mechanical operation loads over the ITER equatorial level port plug structures. This paper presents a detailed finite element simulation and analysis of the transient electromagnetic effects of three different plasma current disruption cases over three designs of diagnostic shielding module (DSM) structure. The DSMs are contained into and supported by the generic equatorial port plug (GEPP) analyzed structure. The three plasma disruption cases studied were: major disruption upwards linear decay in 36 ms (MD UP LIN36), vertical displacements events, upwards and downwards linear decay in 36 ms (VDE UP LIN36 and VDE DW LIN36). A detailed analysis for GEPP structure and three DSM-first wall (FW) designs (horizontal and vertical drawers and monoblock) is also presented in order to extract the Eddy current distribution on these devices and thus the resultant electromagnetic forces and moments acting on them.

  6. A developmental timing switch promotes axon outgrowth independent of known guidance receptors.

    Directory of Open Access Journals (Sweden)

    Katherine Olsson-Carter

    2010-08-01

    Full Text Available To form functional neuronal connections, axon outgrowth and guidance must be tightly regulated across space as well as time. While a number of genes and pathways have been shown to control spatial features of axon development, very little is known about the in vivo mechanisms that direct the timing of axon initiation and elongation. The Caenorhabditis elegans hermaphrodite specific motor neurons (HSNs extend a single axon ventrally and then anteriorly during the L4 larval stage. Here we show the lin-4 microRNA promotes HSN axon initiation after cell cycle withdrawal. Axons fail to form in lin-4 mutants, while they grow prematurely in lin-4-overexpressing animals. lin-4 is required to down-regulate two inhibitors of HSN differentiation--the transcriptional regulator LIN-14 and the "stemness" factor LIN-28--and it likely does so through a cell-autonomous mechanism. This developmental switch depends neither on the UNC-40/DCC and SAX-3/Robo receptors nor on the direction of axon growth, demonstrating that it acts independently of ventral guidance signals to control the timing of HSN axon elongation.

  7. 專論/台灣圖書館史數位圖書館建構之研究/王梅玲;蔡明月;陳志銘;柯雲娥;蔡佳縈;陳勇汀;林怡甄 | A Digital Library Pilot Study on Taiwan Libraries' History / Mei-Ling Wang; Ming-Yueh Tsay; Chih-Ming Chen; Yun-Er Ke; Chia-Ying Tsai; Yong-Ting Chen; Yi-Jen Lin

    Directory of Open Access Journals (Sweden)

    王梅玲、蔡明月、陳志銘、柯雲娥、蔡佳縈、陳勇汀、林怡甄

    2008-04-01

    Full Text Available

    圖書館是保存與詮釋人類文化重要的機構,1990 年代開始,網際網路的進步,促成數位圖書館蓬勃發展,有人預測它就是未來的圖書館,因此,圖書館界與教育界積極參與相關研究。台灣地區歷經日據時期、重建 時期、成長時期及茁壯時期四階段,建設許多圖書館,有其豐富的主題與素材值得發展成為數位圖書館。政治大學圖書資訊與檔案學研究所有鑑於此,提出「『台灣 百無圖書館史』數位圖書館」的構想,並獲得政大「發展國際一流大學及頂尖研究中心計畫」經費支持。本研究計畫目的包括:(1探索以台彎圖書館事業史為主 題的數位圖書館建構模式;(2建構數位圖書館以支援圖書資訊學教育與研究;(3研訂圖書館事業史料文獻的Metadata與數位資料格式;(4將圖 書文獻與文物數位化以建構數位館藏;(5發展數位圖書館系統與技術;(6研發數位圖書館網站的瀏覽與檢索功能;(7探討數位圖書館支援數位學習的模 式。計畫成果共研訂六種 Metadata標準:建置746筆數位化資料;以Dspace系統平台,依據需求設計台灣百年圖書館史系統架構與網站,最後提出結論與建議。

    Libraries are important social institutions that preserve and communicate human culture and knowledge. From the beginning of 1990s, the digital library has grown up rapidly based on the progress of the Internet. Libraries and educational institutions should be actively involved in digital library research and development. The Taiwan libraries’ history can be divided into four stages: Japanese occupation period, reconstruction period, growth period and strong period. In these processes, many events and libraries with rich materials that can be developed into a digital library. Graduate Institute of Library, Information and Archival Studies, National Chengchi University, planned the Digital Library Pilot Study on Taiwan Libraries’ History and got the university support. The pilot study objectives include: (1 exploring the digital library model on Taiwan libraries' history; (2 constructing digital library to support education and research in information and library science; (3 developing Metadata standards of library documents and heritage; (4 digitalizing documents and heritage to build digital collections (5 developing digital library systems and technology; (6 researching browsing and search functions of the digital library; (7 exploring the model of the digital library supports e-learning. In this pilot study, we developed six Metadata standards, built 746 digital resources, constructed a digital library system and web site, and proposed the conclusions and suggestions finally.

    頁次:15-38

  8. Joint Force Quarterly. Number 9, Autumn 1995

    Science.gov (United States)

    1995-11-01

    Peters, Jr. Production Coordinator Calvin B. Kelley Senior Copy Editor Justin Burkhart Editorial Intern (Summer 1995) The Typography and Design ...J. Rokke ■ C O N T E N T S 2 JFQ / Autumn 1995 ■ O U T O F J O I N T 24 Jointness by Design , Not Accident by Michael C. Vitale ■ J F Q F O R U M...take power, or Iran and Iraq have a free hand, U.S. interests would suffer a serious setback. These factors have altered the region’s geo- graphic

  9. Imaging features of type 1 hereditary tyrosinemia: a review of 30 patients

    Energy Technology Data Exchange (ETDEWEB)

    Dubois, J. [Department of Radiology, Hopital Sainte-Justine, Montreal, Que. (Canada); Garel, L. [Department of Radiology, Hopital Sainte-Justine, Montreal, Que. (Canada); Patriquin, H. [Department of Radiology, Hopital Sainte-Justine, Montreal, Que. (Canada); Paradis, K. [Department of Pediatrics, Gastroenterology, Universite de Montreal, Que. (Canada); Forget, S. [Department of Pediatrics, Gastroenterology, Universite de Montreal, Que. (Canada); Filiatrault, D. [Department of Radiology, Hopital Sainte-Justine, Montreal, Que. (Canada); Grignon, A. [Department of Radiology, Hopital Sainte-Justine, Montreal, Que. (Canada); Russo, P. [Department of Pathology, Hopital Sainte-Justine, Montreal, Que. (Canada); St-Vil, D. [Department of Surgery, Hopital Sainte-Justine, Montreal, Que. (Canada)

    1996-12-01

    Hereditary tyrosinemia type 1, a common genetic disorder in the province of Quebec, is characterized by a deficiency of fumarylacetoacetate hydrolase. In this autosomal recessive disorder of tyrosine metabolism, the accumulation of succinylacetone leads to neurologic crises, acute and chronic liver failure, complex renal tubulopathy, rickets and a hemorrhagic syndrome. Liver trans- plantation has dramatically modified the spontaneous course of this lethal disease. The present paper describes the imaging fea- tures of tyrosinemia in 30 patients followed from 1980 to 1995 at Hopital Sainte-Justine, Montreal, Canada. (orig.). With 10 figs., 2 tabs.

  10. Work on CMS Muon Detector (CSCs) during Long Shutdown 1

    CERN Multimedia

    Lapka, Marzena

    2015-01-01

    These U.S. physicists made crucial contributions in preparing new electronics in the CMS effort to refurbish the first layer of the muon detector endcap. This effort recently passed a major review, suggesting the project is on track to be part of the experiment when detector operations resumes in early 2015. From left to right: Wells Wulsin (Oklahoma State), Nick Amin (Texas A&M), Indara Suarez (Texas A&M), Shalhout Shalhout (UC Davis), Joe Haley (Northeastern), Michael Gardner (UC Davis), and Justin Pilot (UC Davis). Inset: Joe Golf (left) and Manuel Franco Sevilla, both of UC Santa Barbara.

  11. Investigation of spontaneously broken gauge theories

    International Nuclear Information System (INIS)

    Nagy, T.

    1978-01-01

    Spontaneously broken gauge theories (SBGT) with effects treated perturbatively are investigated. The general structure of SBGT is exhibited and gauge invariant renormalization program for practical calculations is set up. The proof of renormalizability of Lee and Zinn-Justin are extended to the problems of SBGT. A general semisimple compact gauge group is used. Arbitrary fermion and scalar multiplets are considered. The structure of the Lagrangian is discussed. The problem of quantization is described and the definition of the generating functionals of the Green functions and the Green functions themselves is given

  12. Square Deal: Lower Bounds and Improved Relaxations for Tensor Recovery

    Science.gov (United States)

    2013-08-16

    problem size n from 10 to 30 with increment 1, and the observation ratio ρ from 0.01 to 0.2 with increment 0.01. For each (ρ, n)-pair, we simulate 5 test ...Foundations of Computational Mathematics, 12(6):805–849, 2012. [CRT] Emmanuel J. Candès, Justin K. Romberg , and Terence Tao. Stable signal recov- ery...2012. [SDS10] Marco Signoretto, Lieven De Lathauwer, and Johan AK Suykens. Nuclear norms for tensors and their use for convex multilinear estimation

  13. What does Ottawa Know about the F-35 that the Danes Don’t?

    DEFF Research Database (Denmark)

    Schaub Jr, Gary John; Leuprecht, Christian

    2016-01-01

    The Canadian government of Justin Trudeau reportedly wants to sole source an "interim" purchase of F/A-18 Super Hornets without engaging in a full analysis of alternatives -- precisely how his predecessor ran into trouble with the F-35. Christian Leuprecht and I argue in an op-ed in the Toronto...... Star that Canada should follow the same procurement process as Denmark: a transparent, public, and independently validated analysis of alternatives. This has allowed the Danes to proceed quickly and uncontroversially with the largest military purchase in Danish history. There are lessons here...

  14. 2009 Report to Congress of the U.S-China Economic and Security Review Commission

    Science.gov (United States)

    2009-11-01

    DC: U.S. Department of Commerce, 2009). http://www. bis.doc.gov/news/2009/bislannual reportl08.pdf. 17. Andrew Batson, ‘‘Rise in China’s Forex ...global economic profile by in- vesting overseas and acquiring foreign assets. Jamil Anderlini, ‘‘China to Deploy Forex Reserves,’’ Financial Times, July...8, 2009. 76. Justine Lau and John Burton, ‘‘China Names New Forex Chief,’’ Financial Times, July 17, 2009. 77. Wen Xiu, Zhang Man, and Wang Ziwu

  15. vct 251,uop vct 251,vct 251 entire course new

    OpenAIRE

    admin

    2018-01-01

    UOP VCT 251 Week 1 Individual: Graphic Icon NEW Check this A+ tutorial guideline at http://www.assignmentcloud.com/vct-251-uop/vct-251-week-1-individual-graphic-icon-new For more classes visit http://www.assignmentcloud.com/ VCT 251 Week 1 Individual: Graphic Icon NEW Review Lessons 1, 2, and 3 of Adobe® Illustrator® CC™ Digital Classroom and the Lynda.com® video “Introduction to Graphic Design with Justin Seeley”. Create your first Illustrat...

  16. Development of a 2,4-Dinitrotoluene-Responsive Synthetic Riboswitch in E. coli cells

    Science.gov (United States)

    2012-09-01

    INTRODUCTION Riboswitches are naturally-occurring genetic regulatory elements found in the 5′ untranslated region of some mRNA. They provide a method...Industrial Genetics at the University of Stuttgart, Germany, respectively. The plasmid pSAL8.1 was kindly provided by Dr. Justin Gallivan from Emory...vol. 252: Ribozymes and siRNA Protocols, 2nd ed. Humana Press, Inc.; 2004, 145-164. (9) Suess, B., and Weigand, J.E. RNA Biology 2008, 5(1), 1-6

  17. Jacques Lacan and the Other Side of Psychoanalysis: Reflections on Seminar XVII (Book Review

    Directory of Open Access Journals (Sweden)

    Lizzy Newman

    2006-01-01

    Full Text Available A review of Justin Clemens and Russell Grigg (eds., Jacques Lacan and the Other Side of Psychoanalysis: Reflections on Seminar XVII, Duke University Press, 2006. ISBN: 0-8223-3719-3.A new book that brings together 16 essays, mostly all commentaries upon Lacan''s Seminar XVII, known as 'The other Side of Psychoanalysis'. Topics include the four discourses, the relation between psychoanalysis and contemporary social discourses, the question of social change, the relationship between psychoanalysis and politics, and the structuring function of the Oedipus complex.

  18. Jacques Lacan and the Other Side of Psychoanalysis: Reflections on Seminar XVII

    Directory of Open Access Journals (Sweden)

    Lizzy Newman

    2006-10-01

    Full Text Available pA review of Justin Clemens and Russell Grigg (eds., Jacques Lacan and the Other Side of Psychoanalysis: Reflections on Seminar XVII, Duke University Press, 2006. ISBN: 0-8223-3719-3./ppA new book that brings together 16 essays, mostly all commentaries upon Lacan#39;#39;s Seminar XVII, known as #39;The other Side of Psychoanalysis#39;. Topics include the four discourses, the relation between psychoanalysis and contemporary social discourses, the question of social change, the relationship between psychoanalysis and politics, and the structuring function of the Oedipus complex. /p

  19. Aproximación al estudio de los discursos en el Epítome de Justino

    Directory of Open Access Journals (Sweden)

    Ballesteros Pastor, Luis

    2009-10-01

    Full Text Available Justin’s Epitome records some speeches that Trogus had included in theHistoriae Philippicae. Justin abridges and modifies a great deal of these passages, which appear in most cases in oratio obliqua, following an option that he attributes to Trogus. Justin’s manipulation of the text makes these discourses very problematic to study: sometimes they are extremely shortened, or they completely lack any kind of settings, or they are moved from their original place, or they may even appear in direct style.

  20. Aproximación al estudio de los discursos en el Epítome de Justino

    Directory of Open Access Journals (Sweden)

    Luis Ballesteros Pastor

    2009-10-01

    Full Text Available Justin’s Epitome records some speeches that Trogus had included in the Historiae Philippicae . Justin abridges and modifies a great deal of these passages, which appear in most cases in oratio obliqua, following an option that he attributes to Trogus. Justin’s manipulation of the text makes these discourses very problematic to study: sometimes they are extremely shortened, or they completely lack any kind of settings, or they are moved from their original place, or they may even appear in direct style.

  1. Paremad Briti palad / Jüri Muttika

    Index Scriptorium Estoniae

    Muttika, Jüri

    2008-01-01

    Lühike arvustus-tutvustus 2008.a. filmidele "Nälg" ("Hunger"), režissöör Steve McQueen, "Slummi miljonär" ("Slumdog Millionaire"), režissöör Sanny Boyle, "Kergemeelsed elukombed" ("Easy Virtue"), režissöör Stephan Elliott, "Uue linna tapjad" ("New Town Killers"), režissöör Richard Jobson ja "Ma tean, et sa tead" ("I Know You Know"), režissöör Justin Kerrigan

  2. Stress Survival Islet 2, Predominantly Present in Listeria monocytogenes Strains of Sequence Type 121, Is Involved in the Alkaline and Oxidative Stress Responses.

    Science.gov (United States)

    Harter, Eva; Wagner, Eva Maria; Zaiser, Andreas; Halecker, Sabrina; Wagner, Martin; Rychli, Kathrin

    2017-08-15

    The foodborne pathogen Listeria monocytogenes is able to survive a variety of stress conditions leading to the colonization of different niches like the food processing environment. This study focuses on the hypervariable genetic hot spot lmo0443 to lmo0449 haboring three inserts: the stress survival islet 1 (SSI-1), the single-gene insert LMOf2365_0481 , and two homologous genes of the nonpathogenic species Listeria innocua : lin0464 , coding for a putative transcriptional regulator, and lin0465 , encoding an intracellular PfpI protease. Our prevalence study revealed a different distribution of the inserts between human and food-associated isolates. The lin0464-lin0465 insert was predominantly found in food-associated strains of sequence type 121 (ST121). Functional characterization of this insert showed that the putative PfpI protease Lin0465 is involved in alkaline and oxidative stress responses but not in acidic, gastric, heat, cold, osmotic, and antibiotic stresses. In parallel, deletion of lin0464 decreased survival under alkaline and oxidative stresses. The expression of both genes increased significantly under oxidative stress conditions independently of the alternative sigma factor σ B Furthermore, we showed that the expression of the protease gene lin0465 is regulated by the transcription factor lin0464 under stress conditions, suggesting that lin0464 and lin0465 form a functional unit. In conclusion, we identified a novel stress survival islet 2 (SSI-2), predominantly present in L. monocytogenes ST121 strains, beneficial for survival under alkaline and oxidative stresses, potentially supporting adaptation and persistence of L. monocytogenes in food processing environments. IMPORTANCE Listeria monocytogenes strains of ST121 are known to persist for months and even years in food processing environments, thereby increasing the risk of food contamination and listeriosis. However, the molecular mechanism underlying this remarkable niche-specific adaptation

  3. REASONING OF LIBERAL ISLAM: A STUDY ON ISLAMIC PERSPECTIVES IN LIBERAL ISLAM NETWORK JAKARTA

    Directory of Open Access Journals (Sweden)

    Yusa' Farchan

    2016-12-01

    Full Text Available The renewal of Islamic thinking continuously develops from time to time in Indonesia. This research tries to answer two main problems, they are: how are the reasoning or ideology developed by Liberal Islam Network (LIN?; and how are LIN’s main ideas and their metamorphoses? The research applies qualitative method with hermeneutic approach. The data is collected by library research or text documentation. The data is collected on August 18th to August 29th 2015. The research finds that the ideas of Liberal Islam Network show significant liberal signs. From the ontology of text, in reading religious text, LIN’s assumptions are “the critics over the truth”. LIN applies humanistic approach in reading the religious texts. This is confirmed by LIN’s defense toward human’s dignity. From the aspect of theoretically analytical tools in reading religious texts, LIN applies social sciences, which are socio-historical analyses. LIN uses symbol or semiotics analyses to read the religious text. The main notions of LIN are: First, Islam changes, it is not static; second, context is the first and history is the latter. Here, in reading a religious text, LIN wants to place context (socio-history proportionally; third, LIN intends to hold God in our ground and history. The metamorphoses of LIN’s ideas are: firstly is to oppose theocracy; secondly is to endorse democracy; thirdly is to endorse gender equality; fourthly is to contextualize religious doctrines; and fifthly is to support pluralism and freedom of thinking.

  4. The influence of BDNF on human umbilical cord blood stem/progenitor cells: implications for stem cell-based therapy of neurodegenerative disorders.

    Science.gov (United States)

    Paczkowska, Edyta; Łuczkowska, Karolina; Piecyk, Katarzyna; Rogińska, Dorota; Pius-Sadowska, Ewa; Ustianowski, Przemysław; Cecerska, Elżbieta; Dołęgowska, Barbara; Celewicz, Zbigniew; Machaliński, Bogusław

    2015-01-01

    Umbilical cord blood (UCB)-derived stem/progenitor cells (SPCs) have demonstrated the potential to improve neurologic function in different experimental models. SPCs can survive after transplantation in the neural microenvironment and indu ce neuroprotection, endogenous neurogenesis by secreting a broad repertoire of trophic and immunomodulatory cytokines. In this study, the influence of brain-derived neurotrophic factor (BDNF) pre-treatment was comprehensively evaluated in a UCB-derived lineage-negative (Lin-) SPC population. UCB-derived Lin- cells were evaluated with respect to the expression of (i) neuronal markers using immunofluorescence staining and (ii) specific (TrkB) receptors for BDNF using flow cytometry. Next, after BDNF pre-treatment, Lin- cells were extensively assessed with respect to apoptosis using Western blotting and proliferation via BrdU incorporation. Furthermore, NT-3 expression levels in Lin- cells using RQ PCR and antioxidative enzyme activities were assessed. We demonstrated neuronal markers as well as TrkB expression in Lin- cells and the activation of the TrkB receptor by BDNF. BDNF pre-treatment diminished apoptosis in Lin- cells and influenced the proliferation of these cells. We observed significant changes in antioxidants as well as in the increased expression of NT-3 in Lin- cells following BDNF exposure. Complex global miRNA and mRNA profiling analyses using microarray technology and GSEA revealed the differential regulation of genes involved in the proliferation, gene expression, biosynthetic processes, translation, and protein targeting. Our results support the hypothesis that pre-treatment of stem/progenitor cells could be beneficial and may be used as an auxiliary strategy for improving the properties of SPCs.

  5. C. elegans microRNAs.

    Science.gov (United States)

    Vella, Monica C; Slack, Frank J

    2005-09-21

    MicroRNAs (miRNAs) are small, non-coding regulatory RNAs found in many phyla that control such diverse events as development, metabolism, cell fate and cell death. They have also been implicated in human cancers. The C. elegans genome encodes hundreds of miRNAs, including the founding members of the miRNA family lin-4 and let-7. Despite the abundance of C. elegans miRNAs, few miRNA targets are known and little is known about the mechanism by which they function. However, C. elegans research continues to push the boundaries of discovery in this area. lin-4 and let-7 are the best understood miRNAs. They control the timing of adult cell fate determination in hypodermal cells by binding to partially complementary sites in the mRNA of key developmental regulators to repress protein expression. For example, lin-4 is predicted to bind to seven sites in the lin-14 3' untranslated region (UTR) to repress LIN-14, while let-7 is predicted to bind two let-7 complementary sites in the lin-41 3' UTR to down-regulate LIN-41. Two other miRNAs, lsy-6 and mir-273, control left-right asymmetry in neural development, and also target key developmental regulators for repression. Approximately one third of the C. elegans miRNAs are differentially expressed during development indicating a major role for miRNAs in C. elegans development. Given the remarkable conservation of developmental mechanism across phylogeny, many of the principles of miRNAs discovered in C. elegans are likely to be applicable to higher animals.

  6. Murine bone marrow Lin⁻Sca⁻1⁺CD45⁻ very small embryonic-like (VSEL cells are heterogeneous population lacking Oct-4A expression.

    Directory of Open Access Journals (Sweden)

    Krzysztof Szade

    Full Text Available Murine very small embryonic-like (VSEL cells, defined by the Lin(-Sca-1(+CD45(- phenotype and small size, were described as pluripotent cells and proposed to be the most primitive hematopoietic precursors in adult bone marrow. Although their isolation and potential application rely entirely on flow cytometry, the immunophenotype of VSELs has not been extensively characterized. Our aim was to analyze the possible heterogeneity of Lin(-Sca(+CD45(- population and investigate the extent to which VSELs characteristics may overlap with that of hematopoietic stem cells (HSCs or endothelial progenitor cells (EPCs. The study evidenced that murine Lin(-Sca-1(+CD45(- population was heterogeneous in terms of c-Kit and KDR expression. Accordingly, the c-Kit(+KDR(-, c-Kit(-KDR(+, and c-Kit(-KDR(- subpopulations could be distinguished, while c-Kit(+KDR(+ events were very rare. The c-Kit(+KDR(- subset contained almost solely small cells, meeting the size criterion of VSELs, in contrast to relatively bigger c-Kit(-KDR(+ cells. The c-Kit(-KDR(-FSC(low subset was highly enriched in Annexin V-positive, apoptotic cells, hence omitted from further analysis. Importantly, using qRT-PCR, we evidenced lack of Oct-4A and Oct-4B mRNA expression either in whole adult murine bone marrow or in the sorted of Lin(-Sca-1(+CD45(-FSC(low population, even by single-cell qRT-PCR. We also found that the Lin(-Sca-1(+CD45(-c-Kit(+ subset did not exhibit hematopoietic potential in a single cell-derived colony in vitro assay, although it comprised the Sca-1(+c-Kit(+Lin(- (SKL CD34(-CD45(-CD105(+ cells, expressing particular HSC markers. Co-culture of Lin(-Sca-1(+CD45(-FSC(low with OP9 cells did not induce hematopoietic potential. Further investigation revealed that SKL CD45(-CD105(+ subset consisted of early apoptotic cells with fragmented chromatin, and could be contaminated with nuclei expelled from erythroblasts. Concluding, murine bone marrow Lin(-Sca-1(+CD45(-FSC(low cells are

  7. Keep Calm and Learn Multilevel Logistic Modeling: A Simplified Three-Step Procedure Using Stata, R, Mplus, and SPSS

    Directory of Open Access Journals (Sweden)

    Nicolas Sommet

    2017-09-01

    Full Text Available This paper aims to introduce multilevel logistic regression analysis in a simple and practical way. First, we introduce the basic principles of logistic regression analysis (conditional probability, logit transformation, odds ratio. Second, we discuss the two fundamental implications of running this kind of analysis with a nested data structure: In multilevel logistic regression, the odds that the outcome variable equals one (rather than zero may vary from one cluster to another (i.e. the intercept may vary and the effect of a lower-level variable may also vary from one cluster to another (i.e. the slope may vary. Third and finally, we provide a simplified three-step “turnkey” procedure for multilevel logistic regression modeling: -Preliminary phase: Cluster- or grand-mean centering variables -Step #1: Running an empty model and calculating the intraclass correlation coefficient (ICC -Step #2: Running a constrained and an augmented intermediate model and performing a likelihood ratio test to determine whether considering the cluster-based variation of the effect of the lower-level variable improves the model fit -Step #3 Running a final model and interpreting the odds ratio and confidence intervals to determine whether data support your hypothesis Command syntax for Stata, R, Mplus, and SPSS are included. These steps will be applied to a study on Justin Bieber, because everybody likes Justin Bieber.1

  8. Identity and Friendship in Hsu-Ming Teo´s Behind the Moon (2000

    Directory of Open Access Journals (Sweden)

    Catalina Ribas Segura

    2015-03-01

    Full Text Available In her second novel, Behind the Moon (2000, Hsu-Ming Teo explores the identity construction of three teenage friends and how they defy the notion of the „ideal‟ Australian as a heterosexual, Protestant, white, English-speaking, Australian-born of British ancestry young adult person. Set in the western suburbs of Sydney in the 1990s, the three friends are an example of the multicultural society of the time: Justin Cheong, the son of a Chinese-Singaporean family who arrived in Australia with the Business Migration Programme; Tien Ho, a refugee girl of Chinese-Vietnamese and Afro-CajunCreole-American ancestry; and Nigel „Gibbo‟ Gibson, the son of an Anglo-Australian father and an English mother. The novel tackles different relations among these characters and their families during their teenage years and especially as young adults. This paper seeks to analyse the evolution of the identities of Justin, Tien and „Gibbo‟ through the notions of belonging, gender construction and sexuality. In order to do so, the main theories applied will be the insights on homosexuality and on masculinities of Maria Pallotta-Chiarolli (1995 and Raewyn W. Connell (1995 and Manuel Castellsʼ (2010 identity construction theory

  9. Cine-Club

    CERN Multimedia

    Cine-Club

    2011-01-01

    Thursday 1 September at 20:30 / Jeudi 1 Septembre à 20h30 CERN Council Chamber / Salle du Conseil The Constant Gardener By/de : Fernando Meirelles (UK, 2005) 129 min With/avec: Ralph Fiennes, Rachel Weisz, Danny Huston Based on the novel by John le Carré Justin Quayle, an English gentle diplomat, is sent to the Kenyan Embassy to work. He takes his wife Tessa, an impulsive woman that he met in a conference. Tessa is a tenacious activist that fights for the rights of the poor people and she helps Doctor Arnold Bluhm. Tessa finds out accidentally that a powerful pharmacist firm (3 Bees) is trialling a new drug amongst the Africans. Tessa is more involved in the matter and she decides to ask Sandy, Justin’s friend, for help because she does not want to involve to her husband. Tessa is murdered in a trip to the north of Kenya and the authorities try to accuse Arnold of the crime. Justin, with a passion for gardening, decides to uncover the truth behind the death of his wife ...

  10. Exploring the Relationships Between Just-In-Time Technique and Manufacturing Performance: Empirical Evidence From Selected Nigerian Firms

    Directory of Open Access Journals (Sweden)

    Ph. D. John Kolade Obamiro

    2009-12-01

    Full Text Available This study explores the relationship between just-in-time technique and manufacturing performance of some selected Nigerian companies. Just-in time was considered to be an overall organisational phenomenon. Data were obtained through a structured questionnaire from a sample size of 300 knowledgeable employees to test the developed model and formulated hypotheses that cover both just-intime and the supporting infrastructures. Bivariate correlation analysis was used to test the three hypotheses. The results showed that: (1 there was a significant relationship between total quality management (supporting infrastructure and just-in-time practices; (2 Human resources management (supporting infrastructure was positively related to just-in-time practices; (3 there was a positive significant relationship between Just-in-time practices and manufacturing performance. These results demonstrate that justin- time practices can be successfully implemented if certain supporting infrastructures are provided, and also support the notion that just-in-time should be practiced at all levels and departments of the organisation, rather than viewing it strictly for shop floor workers.

  11. Carboxy-terminal truncation activates glp-1 protein to specify vulval fates in Caenorhabditis elegans.

    Science.gov (United States)

    Mango, S E; Maine, E M; Kimble, J

    1991-08-29

    The glp-1 and lin-12 genes encode homologous transmembrane proteins that may act as receptors for cell interactions during development. The glp-1 product is required for induction of germ-line proliferation and for embryogenesis. By contrast, lin-12 mediates somatic cell interactions, including those between the precursor cells that form the vulval hypodermis (VPCs). Here we analyse an unusual allele of glp-1, glp-1(q35), which displays a semidominant multivulva phenotype (Muv), as well as the typical recessive, loss-of-function Glp phenotypes (sterility and embryonic lethality). We find that the effects of glp-1(q35) on VPC development mimic those of dominant lin-12 mutations, even in the absence of lin-12 activity. The glp-1(q35) gene bears a nonsense mutation predicted to eliminate the 122 C-terminal amino acids, including a ProGluSerThr (PEST) sequence thought to destabilize proteins. We suggest that the carboxy terminus bears a negative regulatory domain which normally inactivates glp-1 in the VPCs. We propose that inappropriate glp-1(q35) activity can substitute for lin-12 to determine vulval fate, perhaps by driving the VPCs to proliferate.

  12. Growth reduction of Listeria spp. caused by undefined industrial red smear cheese cultures and bacteriocin-producing Brevibacterium lines as evaluated in situ on soft cheese.

    Science.gov (United States)

    Eppert, I; Valdés-Stauber, N; Götz, H; Busse, M; Scherer, S

    1997-01-01

    The undefined microbial floras derived from the surface of ripe cheese which are used for the ripening of commercial red smear cheeses have a strong impact on the growth of Listeria spp. In some cases, these microbial consortia inhibit Listeria almost completely. From such undefined industrial cheese-ripening floras, linocin M18-producing (lin+) (N. Valdés-Stauber and S. Scherer, Appl. Environ. Microbiol. 60:3809-3814, 1994) and -nonproducing Brevibacterium linens strains were isolated and used as single-strain starter cultures on model red smear cheeses to evaluate their potential inhibitory effects on Listeria strains in situ. On cheeses ripened with lin+ strains, a growth reduction of L. ivanovii and L. monocytogenes of 1 to 2 log units was observed compared to cheeses ripened with lin strains. Linocin M18 activity was detected in cheeses ripened with lin+ strains but was not found in those ripened with lin strains. We suggest that production of linocin M18 contributes to the growth reduction of Listeria observed on model red smear cheeses but is unsufficient to explain the almost complete inhibition of Listeria caused by some undefined microbial floras derived from the surface of ripe cheeses. PMID:9406400

  13. Wobbled electronic properties of lithium clusters: Deterministic approach through first principles

    Science.gov (United States)

    Kushwaha, Anoop Kumar; Nayak, Saroj Kumar

    2018-03-01

    The innate tendency to form dendritic growth promoted through cluster formation leading to the failure of a Li-ion battery system have drawn significant attention of the researchers towards the effective destabilization of the cluster growth through selective implementation of electrolytic media such as acetonitrile (MeCN). In the present work, using first principles density functional theory and continuum dielectric model, we have investigated the origin of oscillatory nature of binding energy per atom of Lin (n ≤ 8) under the influence of MeCN. In the gas phase, we found that static mean polarizability is strongly correlated with binding energy and shows oscillatory nature with cluster size due to the open shell of Lin cluster. However, in acetonitrile medium, the binding energy has been correlated with electrostatic Lin -MeCN interaction and it has been found that both of them possess wobbled behavior characterized by the cluster size.

  14. Human cord blood progenitors with high aldehyde dehydrogenase activity improve vascular density in a model of acute myocardial infarction

    Directory of Open Access Journals (Sweden)

    Creer Michael H

    2010-03-01

    Full Text Available Abstract Human stem cells from adult sources have been shown to contribute to the regeneration of muscle, liver, heart, and vasculature. The mechanisms by which this is accomplished are, however, still not well understood. We tested the engraftment and regenerative potential of human umbilical cord blood-derived ALDHhiLin-, and ALDHloLin- cells following transplantation to NOD/SCID or NOD/SCID β2m null mice with experimentally induced acute myocardial infarction. We used combined nanoparticle labeling and whole organ fluorescent imaging to detect human cells in multiple organs 48 hours post transplantation. Engraftment and regenerative effects of cell treatment were assessed four weeks post transplantation. We found that ALDHhiLin- stem cells specifically located to the site of injury 48 hours post transplantation and engrafted the infarcted heart at higher frequencies than ALDHloLin- committed progenitor cells four weeks post transplantation. We found no donor derived cardiomyocytes and few endothelial cells of donor origin. Cell treatment was not associated with any detectable functional improvement at the four week endpoint. There was, however, a significant increase in vascular density in the central infarct zone of ALDHhiLin- cell-treated mice, as compared to PBS and ALDHloLin- cell-treated mice. Conclusions Our data indicate that adult human stem cells do not become a significant part of the regenerating tissue, but rapidly home to and persist only temporarily at the site of hypoxic injury to exert trophic effects on tissue repair thereby enhancing vascular recovery.

  15. Two and three way spectrophotometric-assisted multivariate determination of linezolid in the presence of its alkaline and oxidative degradation products and application to pharmaceutical formulation

    Science.gov (United States)

    Hegazy, Maha Abd El-Monem; Eissa, Maya Shaaban; Abd El-Sattar, Osama Ibrahim; Abd El-Kawy, Mohammad

    2014-07-01

    Linezolid (LIN) is determined in the presence of its alkaline (ALK) and oxidative (OXD) degradation products without preliminary separation based on ultraviolet spectrophotometry using two-way chemometric methods; principal component regression (PCR) and partial least-squares (PLS), and three-way chemometric methods; parallel factor analysis (PARAFAC) and multi-way partial least squares (N-PLS). A training set of mixtures containing LIN, ALK and OXD; was prepared in the concentration ranges of 12-18, 2.4-3.6 and 1.2-1.8 μg mL-1, respectively according to a multilevel multifactor experimental design. The multivariate calibrations were obtained by measuring the zero-order absorbance from 220 to 320 nm using the training set. The validation of the multivariate methods was realized by analyzing their synthetic mixtures. The capabilities of the chemometric analysis methods for the analysis of real samples were evaluated by determination of LIN in its pharmaceutical preparation with satisfactory results. The accuracy of the methods, evaluated through the root mean square error of prediction (RMSEP), was 0.058, 0.026, 0.101 and 0.026 for LIN using PCR, PLS, PARAFAC and N-PLS, respectively. Protolytic equilibria of LIN and its degradation products were evaluated using the corresponding absorption spectra-pH data obtained with PARAFAC. The obtained pKa values of LIN, ALK and OXD are 5.70, 8.90 and 6.15, respectively. The results obtained were statistically compared to that of a reported HPLC method, and there was no significant difference between the proposed methods and the reported method regarding both accuracy and precision.

  16. Complementary feeding messages that target cultural barriers enhance both the use of lipid-based nutrient supplements and underlying feeding practices to improve infant diets in rural Zimbabwe.

    Science.gov (United States)

    Paul, Keriann H; Muti, Monica; Chasekwa, Bernard; Mbuya, Mduduzi N N; Madzima, Rufaro C; Humphrey, Jean H; Stoltzfus, Rebecca J

    2012-04-01

    Supplementation with lipid-based nutrient supplements (LiNS) is promoted as an approach to prevent child undernutrition and growth faltering. Previous LiNS studies have not tested the effects of improving the underlying diet prior to providing LiNS. Formative research was conducted in rural Zimbabwe to develop feeding messages to improve complementary feeding with and without LiNS. Two rounds of Trials of Improved Practices were conducted with mothers of infants aged 6-12 months to assess the feasibility of improving infant diets using (1) only locally available resources and (2) locally available resources plus 20 g of LiNS as Nutributter®/day. Common feeding problems were poor dietary diversity and low energy density. Popular improved practices were to process locally available foods so that infants could swallow them and add processed local foods to enrich porridges. Consumption of beans, fruits, green leafy vegetables, and peanut/seed butters increased after counselling (P < 0.05). Intakes of energy, protein, vitamin A, folate, calcium, iron and zinc from complementary foods increased significantly after counselling with or without the provision of Nutributter (P < 0.05). Intakes of fat, folate, iron, and zinc increased only (fat) or more so (folate, iron, and zinc) with the provision of Nutributter (P < 0.05). While provision of LiNS was crucial to ensure adequate intakes of iron and zinc, educational messages that were barrier-specific and delivered directly to mothers were crucial to improving the underlying diet. © 2010 Blackwell Publishing Ltd.

  17. Optimization of linear consecutive-k-out-of-n system with a Birnbaum importance-based genetic algorithm

    International Nuclear Information System (INIS)

    Cai, Zhiqiang; Si, Shubin; Sun, Shudong; Li, Caitao

    2016-01-01

    The optimization of linear consecutive-k-out-of-n (Lin/Con/k/n) is to find an optimal component arrangement where n components are assigned to n positions to maximize the system reliability. With the interchangeability of components in practical systems, the optimization of Lin/Con/k/n systems is becoming widely applied in engineering practice, which is also a typical component assignment problem concerned by many researchers. This paper proposes a Birnbaum importance-based genetic algorithm (BIGA) to search the near global optimal solution for Lin/Con/k/n systems. First, the operation procedures and corresponding execution methods of BIGA are described in detail. Then, comprehensive simulation experiments are implemented on both small and large systems to evaluate the performance of the BIGA by comparing with the Birnbaum importance-based two-stage approach and Birnbaum importance-based genetic local search algorithm. Thirdly, further experiments are provided to discuss the applicability of BIGA for Lin/Con/k/n system with different k and n. Finally, the case study on oil transportation system is implemented to demonstrate the application of BIGA in the optimization of Lin/Con/k/n system. - Highlights: • BIGA integrates BI and GA to solve the Lin/Con/k/n systems optimization problems. • The experiment results show that the BIGA performs well in most conditions. • Suggestions are given for the application of BIGA and BITA with different k and n. • The application procedure of BIGA is demonstrated by the oil transportation system.

  18. acn-1, a C. elegans homologue of ACE, genetically interacts with the let-7 microRNA and other heterochronic genes.

    Science.gov (United States)

    Metheetrairut, Chanatip; Ahuja, Yuri; Slack, Frank J

    2017-10-02

    The heterochronic pathway in C. elegans controls the relative timing of cell fate decisions during post-embryonic development. It includes a network of microRNAs (miRNAs), such as let-7, and protein-coding genes, such as the stemness factors, LIN-28 and LIN-41. Here we identified the acn-1 gene, a homologue of mammalian angiotensin-converting enzyme (ACE), as a new suppressor of the stem cell developmental defects of let-7 mutants. Since acn-1 null mutants die during early larval development, we used RNAi to characterize the role of acn-1 in C. elegans seam cell development, and determined its interaction with heterochronic factors, including let-7 and its downstream interactors - lin-41, hbl-1, and apl-1. We demonstrate that although RNAi knockdown of acn-1 is insufficient to cause heterochronic defects on its own, loss of acn-1 suppresses the retarded phenotypes of let-7 mutants and enhances the precocious phenotypes of hbl-1, though not lin-41, mutants. Conversely, the pattern of acn-1 expression, which oscillates during larval development, is disrupted by lin-41 mutants but not by hbl-1 mutants. Finally, we show that acn-1(RNAi) enhances the let-7-suppressing phenotypes caused by loss of apl-1, a homologue of the Alzheimer's disease-causing amyloid precursor protein (APP), while significantly disrupting the expression of apl-1 during the L4 larval stage. In conclusion, acn-1 interacts with heterochronic genes and appears to function downstream of let-7 and its target genes, including lin-41 and apl-1.

  19. Thrombocytopenia responding to red blood cell transfusion

    International Nuclear Information System (INIS)

    Mubarak, Ahmad A.; Awidi, Abdalla; Rasul, Kakil I.; Al-Homsi, Ussama

    2004-01-01

    Three patients with severe symptomatic iron defficiency anemia and thrombocytopenia had a significant rise in the platelet count a few days following packed red blood cell transfusion. Pretransfusion platelet count of of patient one was 17x10/L. 22x10/Lin patient two and 29x10/L in patient three. On the 6th day of post tranfusion, the platelet count rose to 166x10/Lin patient one, 830x10/L in patient two and 136x10/L in patient three. The possible mechcnism behind such an unreported observation are discussed. (author)

  20. The CRREL Instrumented Vehicle: Hardware and Software.

    Science.gov (United States)

    1983-01-01

    PRINT CHRS( 1 ’ 57Ŕ PRINT LINkI ) � I NPuT "DO ,OU ST ILL WANT A TPA.T ION VALUE F ’f N’’’",Pp I 5750 IF RpISl"N" THEN GOTO 6510 57,?0 PRINT PAGE... LINkI ,"TYPEOR UNDEPL,ING SURFACE: "Te9’ 7’ PRINT LIN( 1,"DEPTN OR THICaNESS: " T, Sc,;" CM" -o PRINT LIN, I’,"MATEPIAL TEMP: "TS’ II 1*’ DEC C",L:’’ I