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Sample records for julius von sachs

  1. Julius Sachs (1832-1897) and the Unity of Life.

    Science.gov (United States)

    Kutschera, Ulrich; Baluška, František

    2015-01-01

    In 1865, the German botanist Julius Sachs published a seminal monograph entitled Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) and hence became the founder of a new scientific discipline that originated 150 y ago. Here, we outline the significance of the achievements of Sachs. In addition, we document, with reference to his Vorlesungen über Pflanzen-Physiologie (Lectures on the Physiology of Plants, 1882), that Sachs was one of the first experimentalists who proposed the functional unity of all organisms alive today (humans, animals, plants and other "vegetable" organisms, such as algae, cyanophyceae, fungi, myxomycetes, and bacteria).

  2. Basic versus applied research: Julius Sachs (1832-1897) and the experimental physiology of plants.

    Science.gov (United States)

    Kutschera, Ulrich

    2015-01-01

    The German biologist Julius Sachs was the first to introduce controlled, accurate, quantitative experimentation into the botanical sciences, and is regarded as the founder of modern plant physiology. His seminal monograph Experimental-Physiologie der Pflanzen (Experimental Physiology of Plants) was published 150 y ago (1865), when Sachs was employed as a lecturer at the Agricultural Academy in Poppelsdorf/Bonn (now part of the University). This book marks the beginning of a new era of basic and applied plant science. In this contribution, I summarize the achievements of Sachs and outline his lasting legacy. In addition, I show that Sachs was one of the first biologists who integrated bacteria, which he considered to be descendants of fungi, into the botanical sciences and discussed their interaction with land plants (degradation of wood etc.). This "plant-microbe-view" of green organisms was extended and elaborated by the laboratory botanist Wilhelm Pfeffer (1845-1920), so that the term "Sachs-Pfeffer-Principle of Experimental Plant Research" appears to be appropriate to characterize this novel way of performing scientific studies on green, photoautotrophic organisms (embryophytes, algae, cyanobacteria).

  3. Julius Von Bismark and Self-absorption without Stigmas

    Directory of Open Access Journals (Sweden)

    Clara Zarza

    2015-11-01

    Full Text Available El pasado mes de junio, la galería Marlborough Chelsea presentaba en el  pabellón de Unlimited de la 46.ª edición de la Feria de Arte de Basilea una enorme performance-instalación del artista alemán Julius von Bismarck. La obra, titulada Egocentric System, presentaba un llamativo hábitat de cemento a modo de gran antena parabólica giratoria donde Von Bismark dormía, comía o escribía en su ordenador y hablaba por teléfono durante los días de la feria. Su presencia en el contexto institucional de la feria, la enorme atención del público y de la prensa parecen incidir en un cambio en la recepción de obras autorrepresentativas que exploran el mundo privado o la experiencia personal.

  4. Julius von Schlosser and the need to reminisce

    Directory of Open Access Journals (Sweden)

    Karl Johns

    2009-12-01

    Full Text Available In the present essay of 1936, Julius Schlosser seems to have originated the term of ‘die Wiener Schule de Kunstgeschichte’. After surviving a period of exasperating rivalry with Josef Strzygowski, seeing so many colleagues go to their graves before completing their favorite projects, and possibly since Wilhelm Waetzoldt decided to omit Austrians from his Deutsche Kunsthistoriker, there were several reasons for a man of his age, experience and critical vigor to take stock of a development which seemed to be heading into an uncertain future.

  5. Art and science interactions - First Collide @CERN public lecture by Julius Von Bismarck

    CERN Document Server

    CERN. Geneva

    2012-01-01

    Creative collisions between the arts and science have begun at CERN with the first Collide@CERN artist, Julius Von Bismarck starting his digital arts residency at the world's largest particle physics laboratory outside Geneva. He was chosen from 395 entries from 40 countries around the world from the Prix Ars Electronica Collide@CERN competition launched last September 2011. To mark this special occasion, the first Collide@CERN public lecture open to everyone will take place on March 21st 2012 at CERN's Globe of Science and Innovation, with a drinks reception at 18.45 and with presentations starting at 19.30. The event is free and will be opened by the Director General of CERN, Professor Rolf-Dieter Heuer and Gerfried Stocker, the Artistic Director of Ars Electronica, Linz, - CERN's international cultural partners for the digital arts Collide@CERN award known as Prix Ars Electronica Collide@CERN in recognition of our joint partnership. Julius Von Bismarck and his CERN science inspiration partner, the physic...

  6. Light and collisions: Julius von Bismark presents an update on his work after his CERN Residency

    CERN Multimedia

    2012-01-01

    On 27 June 2012, Julius von Bismarck, the first winner of the Prix Ars Electronica Collide@CERN, will give a special informal interim lecture for CERN on his ideas and work in progress.   Julius will disclose his personal reactions to his experiences at CERN, sharing with us how particle physics and the laboratory has started having an impact on his artistic practice. As he said when he won the prize at the first Collide@CERN public lecture: “For me, the Collide@CERN residency is a dream come true.” So has reality matched up with his dreams? And why in the first two weeks did he say: “For me already the residency is already a success.” What is his experience of the creative collisions between arts and science? There will be opportunities for the audience to ask questions, and the artist stresses that this will be a personal and informal presentation of ideas in progress. The lecture will take place in the Council Chamber (Room 503-1-001) from 4.3...

  7. Julius von Schlosser: aesthetics, art history and the book’, Report on the 150th Anniversary Conference on Julius von Schlosser, 6th and 7th October 2016: Julius von Schlosser (1866–1938, Internationale Tagung zum 150. Geburtstag, gemeinsam veranstaltet vom Kunsthistorischen Museum Wien und dem Institut für Kunstgeschichte der Universität Wien

    Directory of Open Access Journals (Sweden)

    Matthew Rampley

    2016-12-01

    Full Text Available This report provides an overview of the main themes and questions explored at the conference held in Vienna on the 150th anniversary of the birth of Julius von Schlosser. It considers in particular his attempts to address the challenges presented by what he regarded as the primacy of the aesthetic artefact in art historical discourse. It presents the broader interests of Schlosser’s diverse oeuvre, which ranged from the study of musical instruments and collecting to medieval art and the literature on art.

  8. Julius von Schlosser on Vasari: a translation from Die Kunstliteratur (1924

    Directory of Open Access Journals (Sweden)

    Karl Johns

    2010-06-01

    Full Text Available Although Julius Schlosser is well known by name and as a source for bibliographical references, very few art historians are familiar with the substance of his forty year teaching career which inspired the likes of Kris, Kurz, Bodonyi, Gombrich and many others. Die Kunstliteratur of 1924 became his fifth and final such handbook, and was published with the intention to elucidate the pre-history of the history of art as an academic discipline. It is natural that Giorgio Vasari has a place at the core of such a story. However, Schlosser possessed an unrivalled knowledge of the relevant written and theoretical sources, and his unusually consistent approach found Lorenzo Ghiberti to be the actual founder of the subject and Winckelmann to have finally overcome the relatively pernicious influence of Vasari. This chapter from the centre of his book therefore still today remains the best critical account of Vasari’s writings from a broader point of view.

  9. Tay-Sachs - resources

    Science.gov (United States)

    Resources - Tay-Sachs ... The following organizations provide information on Tay-Sachs disease : US National Library of Medicine -- ghr.nlm.nih.gov/condition/tay-sachs-disease March of Dimes -- www.marchofdimes.com/pnhec/ ...

  10. Julius Petersen 1839-1910. A Biography

    DEFF Research Database (Denmark)

    Lützen, Jesper; Sabidussi, Gert; Toft, Bjarne

    1992-01-01

    A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics.......A biography of the Danish mathematician Julius Petersen and an analysis of his contributions to the development of mathematics....

  11. Tay-Sachs Disease

    Science.gov (United States)

    Tay-Sachs disease is a rare, inherited disease. It is a type of lipid metabolism disorder. It ... cells, causing mental and physical problems. . Infants with Tay-Sachs disease appear to develop normally for the ...

  12. Tay-Sachs Disease

    Science.gov (United States)

    ... without one of those important enzymes, hexosaminidase A (HEXA). So, as those fatty proteins build up in ... can have their unborn babies tested for the HEXA deficit that causes Tay-Sachs disease: If the ...

  13. Authenticating the writings of Julius Caesar

    NARCIS (Netherlands)

    Kestemont, Mike; Stover, Justin; Koppel, Moshe; Karsdorp, F.B.; Daelemans, Walter

    2016-01-01

    In this paper, we shed new light on the authenticity of the Corpus Caesarianum, a group of five commentaries describing the campaigns of Julius Caesar (100–44 BC), the founder of the Roman empire. While Caesar himself has authored at least part of these commentaries, the authorship of the rest of th

  14. Authenticating the writings of Julius Caesar

    NARCIS (Netherlands)

    Kestemont, Mike; Stover, Justin; Koppel, Moshe; Karsdorp, F.B.; Daelemans, Walter

    2016-01-01

    In this paper, we shed new light on the authenticity of the Corpus Caesarianum, a group of five commentaries describing the campaigns of Julius Caesar (100–44 BC), the founder of the Roman empire. While Caesar himself has authored at least part of these commentaries, the authorship of the rest of

  15. Tay-Sachs and Sandhoff Diseases

    Science.gov (United States)

    ... other health conditions > Tay-Sachs and Sandhoff diseases Tay-Sachs and Sandhoff diseases E-mail to a ... each year in the United States. What causes Tay-Sachs and Sandhoff diseases? Both diseases are passed ...

  16. Genetics Home Reference: Tay-Sachs disease

    Science.gov (United States)

    ... Facebook Twitter Home Health Conditions Tay-Sachs disease Tay-Sachs disease Printable PDF Open All Close All ... Javascript to view the expand/collapse boxes. Description Tay-Sachs disease is a rare inherited disorder that ...

  17. SAChES: Scalable Adaptive Chain-Ensemble Sampling.

    Energy Technology Data Exchange (ETDEWEB)

    Swiler, Laura Painton [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ray, Jaideep [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Ebeida, Mohamed Salah [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Huang, Maoyi [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hou, Zhangshuan [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bao, Jie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ren, Huiying [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2017-08-01

    We present the development of a parallel Markov Chain Monte Carlo (MCMC) method called SAChES, Scalable Adaptive Chain-Ensemble Sampling. This capability is targed to Bayesian calibration of com- putationally expensive simulation models. SAChES involves a hybrid of two methods: Differential Evo- lution Monte Carlo followed by Adaptive Metropolis. Both methods involve parallel chains. Differential evolution allows one to explore high-dimensional parameter spaces using loosely coupled (i.e., largely asynchronous) chains. Loose coupling allows the use of large chain ensembles, with far more chains than the number of parameters to explore. This reduces per-chain sampling burden, enables high-dimensional inversions and the use of computationally expensive forward models. The large number of chains can also ameliorate the impact of silent-errors, which may affect only a few chains. The chain ensemble can also be sampled to provide an initial condition when an aberrant chain is re-spawned. Adaptive Metropolis takes the best points from the differential evolution and efficiently hones in on the poste- rior density. The multitude of chains in SAChES is leveraged to (1) enable efficient exploration of the parameter space; and (2) ensure robustness to silent errors which may be unavoidable in extreme-scale computational platforms of the future. This report outlines SAChES, describes four papers that are the result of the project, and discusses some additional results.

  18. Kunstnik ja tema kodu : Carl Timoleon von Neff Piira ja Muuga mõisas / Ants Hein

    Index Scriptorium Estoniae

    Hein, Ants, 1952-

    2004-01-01

    Ateljeedest Euroopas alates 15. sajandist ja Eestis alates 19. sajandist. Pikemalt Julius Kleveri ja Otto Moelleri ateljeest. Maalikunstnik Carl Timoleon von Neffi elust ja loomingust, kunsti kollektsioneerimisest. Piira ja Muuga mõisahoonest, plaanid, sise- ja välisvaated

  19. The Bondi-Sachs Formalism

    CERN Document Server

    Mädler, Thomas

    2016-01-01

    The Bondi-Sachs formalism of General Relativity is a metric-based treatment of the Einstein equations in which the coordinates are adapted to the null geodesics of the spacetime. It provided the first convincing evidence that gravitational radiation is a nonlinear effect of general relativity and that the emission of gravitational waves from an isolated system is accompanied by a mass loss from the system. The asymptotic behaviour of the Bondi-Sachs metric revealed the existence of the symmetry group at null infinity, the Bondi-Metzner-Sachs group, which turned out to be larger than the Poincare group.

  20. Gaudeamus. Het leven van Julius Röntgen (1855-1932). Componist en musicus

    NARCIS (Netherlands)

    Vis, G.N.M.

    2007-01-01

    Gaudeamus Het leven van Julius Röntgen (1855-1932) Componist en musicus Jurjen Vis shows in his thesis Gaudeamus. The life of Julius Röntgen (1855-1932) that already as a young child Julius Röntgen was a remarkable pianist and composer. He was hailed at that time as a second Mendelssohn. In 1874 Rön

  1. A brief account of Julius Planer's life and research

    Directory of Open Access Journals (Sweden)

    R. Bilyy

    2010-01-01

    Full Text Available A brief account of the life and research activities of Julius Planer is presented. Professor Planer is a scientist who lived one and half century ago. However, his studies, in particular, during the years when he headed Department of Anatomy at Universität in Lemberg, nowadays known as the Ivan Franko National University of Lviv in Ukraine, were essential to a modern understanding of liquid crystals. While working at Lviv University, Planer also made several landmark contributions to biomedical science.

  2. Ethical Issues with Genetic Testing for Tay-Sachs.

    Science.gov (United States)

    Clayton, Tricia

    Several genetic disorders are specific to Jewish heritage; one of the most devastating is Tay-Sachs disease.Tay-Sachs is a fatal hereditary disease, causing progressive neurological problems for which there is no cure. Ethical issues surrounding genetic testing for Tay-Sachs within the Jewish community continue to be complex and multifaceted. A perspective of Tay-Sachs, using rights-based ethics and virtue ethics as a theoretical framework, is explored.

  3. Noncommutativity and Humanity -- Julius Wess and his Legacy

    CERN Document Server

    Djordjevic, Goran S

    2014-01-01

    A personal view on Julius Wess's human and scientific legacy in Serbia and the Balkan region is given. Motivation for using noncommutative and nonarchimedean geometry on very short distances is presented. In addition to some mathematical preliminaries, we present a short introduction in adelic quantum mechanics in a way suitable for its noncommutative generalization. We also review the basic ideas and tools embedded in $q$-deformed and noncommutative quantum mechanics. A rather fundamental approach, called deformation quantization, is noted. A few relations between noncommutativity and nonarchimedean spaces, as well as similarities between corresponding quantum theories, in particular, quantum cosmology are pointed out. An extended Moyal product in a frame of an adelic noncommutative quantum mechanics is also considered.

  4. Clasificación Sachs-Hornbostel de instrumentos musicales: una revisión y aplicación desde la perspectiva americana

    OpenAIRE

    Pérez de Arce,José; Gili,Francisca

    2013-01-01

    El sistema de clasificación de instrumentos musicales ideado por Curt Sachs y Erich Moritz von Horbonstel en 1914 es universalmente usado hasta hoy. En este artículo se analizan las razones de esta permanencia y se revisa en general la historia de los distintos criterios usados para clasificar los instrumentos musicales. Igualmente se explica, de acuerdo con nuestra experiencia, el porqué el sistema de Sachs-Hornbostel nos parece el más apropiado para la realidad americana, con énfasis en la ...

  5. George Wilbur: Otto Rank and Hanns Sachs.

    Science.gov (United States)

    Roazen, Paul

    2006-01-01

    George Wilbur, a pioneering Cape Cod psychoanalytic psychiatrist, was a long-standing editor of the journal "American Imago," and an excellent source of information about the Viennese analysts Otto Rank and Hanns Sachs. Wilbur was also knowledgeable about the early reception of psychoanalysis in the Boston community.

  6. Julius – a template based supplementary electronic health record system

    Directory of Open Access Journals (Sweden)

    Klein Gunnar O

    2007-05-01

    Full Text Available Abstract Background EHR systems are widely used in hospitals and primary care centres but it is usually difficult to share information and to collect patient data for clinical research. This is partly due to the different proprietary information models and inconsistent data quality. Our objective was to provide a more flexible solution enabling the clinicians to define which data to be recorded and shared for both routine documentation and clinical studies. The data should be possible to reuse through a common set of variable definitions providing a consistent nomenclature and validation of data. Another objective was that the templates used for the data entry and presentation should be possible to use in combination with the existing EHR systems. Methods We have designed and developed a template based system (called Julius that was integrated with existing EHR systems. The system is driven by the medical domain knowledge defined by clinicians in the form of templates and variable definitions stored in a common data repository. The system architecture consists of three layers. The presentation layer is purely web-based, which facilitates integration with existing EHR products. The domain layer consists of the template design system, a variable/clinical concept definition system, the transformation and validation logic all implemented in Java. The data source layer utilizes an object relational mapping tool and a relational database. Results The Julius system has been implemented, tested and deployed to three health care units in Stockholm, Sweden. The initial responses from the pilot users were positive. The template system facilitates patient data collection in many ways. The experience of using the template system suggests that enabling the clinicians to be in control of the system, is a good way to add supplementary functionality to the present EHR systems. Conclusion The approach of the template system in combination with various local EHR

  7. Perturbations of Kantowski-Sachs models

    CERN Document Server

    Bradley, Michael; Keresztes, Zoltán; Gergely, László Á; Dunsby, Peter K S

    2013-01-01

    Perturbations of Kantowski-Sachs models with a positive cosmological constant are considered in a harmonic decomposition, in the framework of gauge invariant 1+3 and 1+1+2 covariant splits of spacetime. Scalar, vector and tensor modes are allowed, however they remain vorticity-free and of perfect fluid type. The dynamics is encompassed in six evolution equations for six harmonic coefficients.

  8. National Tay-Sachs and Allied Diseases Association, Inc.

    Science.gov (United States)

    Exceptional Parent, 1977

    1977-01-01

    Reviewed are the history and organization, purpose and programs, and public services of the National Tay-Sachs and Allied Diseases Association, an organization geared toward eradicating Tay-Sachs disease (a hereditary disorder affecting primarily Jewish infants which generally leads to deterioration and death by the child's fifth year). (SBH)

  9. The National Tay Sachs and Allied Diseases Association.

    Science.gov (United States)

    Zeitlin, Paula

    1986-01-01

    The National Tay-Sachs and Allied Diseases Association is involved in education, research, and prevention of Tay-Sachs, an inherited metabolic disorder which destroys the central nervous system, and over 30 related disorders. The group features a parent peer group network and a support group for carrier couples. (CL)

  10. The National Tay Sachs and Allied Diseases Association.

    Science.gov (United States)

    Zeitlin, Paula

    1986-01-01

    The National Tay-Sachs and Allied Diseases Association is involved in education, research, and prevention of Tay-Sachs, an inherited metabolic disorder which destroys the central nervous system, and over 30 related disorders. The group features a parent peer group network and a support group for carrier couples. (CL)

  11. National Tay-Sachs and Allied Diseases Association, Inc.

    Science.gov (United States)

    Exceptional Parent, 1977

    1977-01-01

    Reviewed are the history and organization, purpose and programs, and public services of the National Tay-Sachs and Allied Diseases Association, an organization geared toward eradicating Tay-Sachs disease (a hereditary disorder affecting primarily Jewish infants which generally leads to deterioration and death by the child's fifth year). (SBH)

  12. Karl Julius Lohnert - an unknown astronomer, experimental psychologist and teacher (German Title: Karl Julius Lohnert - ein unbekannter Astronom, experimenteller Psychologe und Lehrer)

    Science.gov (United States)

    Schmadel, Lutz D.; Guski-Leinwand, Susanne

    2011-08-01

    Karl Julius Lohnert (1885-1944) with his double biography as astronomer and psychologist is hardly known in both fields. As a student of astronomy in Heidelberg, Lohnert discovered a couple of minor planets and he dedicated one to his PhD supervisor, the famous Leipzig professor for philosophy, Wilhelm Wundt. This connection is discussed for the first time almost one century after the naming of (635) Vundtia. The paper elucidates some biographical stations of Lohnert.

  13. Tay Sachs and Related Storage Diseases: Family Planning

    Science.gov (United States)

    Schneiderman, Gerald; And Others

    1978-01-01

    Based on interviews with 24 families, the article discusses family planning and the choices available to those families in which a child has previously died from Tay-Sachs or related lipid storage diseases. (IM)

  14. Tay Sachs and Related Storage Diseases: Family Planning

    Science.gov (United States)

    Schneiderman, Gerald; And Others

    1978-01-01

    Based on interviews with 24 families, the article discusses family planning and the choices available to those families in which a child has previously died from Tay-Sachs or related lipid storage diseases. (IM)

  15. On Julius Planer's 1861 paper "Notiz über das Cholestearin" in Annalen der Chemie und Pharmacie

    Directory of Open Access Journals (Sweden)

    A. Trokhymchuk

    2010-01-01

    Full Text Available Brief review of the literature on the history of thermotropic liquid crystal discovery and the role of the observations reported by Julius Planer in his note published almost 150 years ago.

  16. Julius Wellhausen � die denke van �n Ou-Testamentikus

    Directory of Open Access Journals (Sweden)

    Gideon J. Serfontein

    2012-02-01

    Full Text Available Julius Wellhausen � the thoughts of an Old Testament scholar. The purpose of this article is to examine the life, influence and greatest works of Old Testament scholar Julius Wellhausen. Wellhausen was influenced by the findings of other Old Testament critics that preceded him, as well as the new environment that the Enlightenment has created. These influences can be seen in his three major works: Die Komposition des Hexateuchs � here an idea of the method he used in the recognition, grouping and dating of the sources can be found. Wellhausen made use of these sources to construct a history of Israel which can be viewed in his Geschichte Israels. His greatest work was most certainly his Prolegomena zur Geschichte Israels and he makes significant findings in the part on the Geschichte des Kultus. The question to be answered though is: Does Wellhausen�s source hypothesis still has a part to play in our modern research on the Pentateuch?

  17. 75 FR 44031 - Goldman, Sachs & Co., et al.; Notice of Application and Temporary Order

    Science.gov (United States)

    2010-07-27

    ... Management International (``GSAMI''), Goldman Sachs Hedge Fund Strategies LLC (``GSHFS''), Commonwealth... global investment banking and securities firm. Goldman Sachs is registered as an investment adviser with... marketing materials used in connection with residential mortgage-related securities offerings by...

  18. Measuring the integrated Sachs-Wolfe effect

    Science.gov (United States)

    Dupé, F.-X.; Rassat, A.; Starck, J.-L.; Fadili, M. J.

    2011-10-01

    Context. One of the main challenges of modern cosmology is to understand the nature of the mysterious dark energy that causes the cosmic acceleration. The integrated Sachs-Wolfe (ISW) effect is sensitive to dark energy, and if detected in a universe where modified gravity and curvature are excluded, presents an independent signature of dark energy. The ISW effect occurs on large scales where cosmic variance is high and where owing to the Galactic confusion we lack large amounts of data in the CMB as well as large-scale structure maps. Moreover, existing methods in the literature often make strong assumptions about the statistics of the underlying fields or estimators. Together these effects can severely limit signal extraction. Aims: We aim to define an optimal statistical method for detecting the ISW effect that can handle large areas of missing data and minimise the number of underlying assumptions made about the data and estimators. Methods: We first review current detections (and non-detections) of the ISW effect, comparing statistical subtleties between existing methods, and identifying several limitations. We propose a novel method to detect and measure the ISW signal. This method assumes only that the primordial CMB field is Gaussian. It is based on a sparse inpainting method to reconstruct missing data and uses a bootstrap technique to avoid assumptions about the statistics of the estimator. It is a complete method, which uses three complementary statistical methods. Results: We apply our method to Euclid-like simulations and show we can expect a ~7σ model-independent detection of the ISW signal with WMAP7-like data, even when considering missing data. Other tests return ~5σ detection levels for a Euclid-like survey. We find that detection levels are independent from whether the galaxy field is normally or lognormally distributed. We apply our method to the 2 Micron All Sky Survey (2MASS) and WMAP7 CMB data and find detections in the 1.0-1.2σ range, as

  19. Rapid detection of fetal Mendelian disorders: Tay-Sachs disease.

    Science.gov (United States)

    Guetta, Esther; Peleg, Leah

    2008-01-01

    Tay-Sachs disease is an autosomal recessive storage disease caused by the impaired activity of the lysosomal enzyme hexosaminidase A. In this fatal disease, the sphingolipid GM2 ganglioside accumulates in the neurons. Due to high carrier rates and the severity of the disease, population screening and prenatal diagnosis of Tay-Sachs disease are routinely carried out in Israel. Laboratory diagnosis of Tay-Sachs is carried out with biochemical and DNA-based methods in peripheral and umbilical cord blood, amniotic fluid, and chorionic villi samples. The assay of hexosaminidase A (Hex A) activity is carried out with synthetic substrates, 4-methylumbelliferyl-6-sulfo-N-acetyl-beta-glucosaminide (4-MUGS) and 4-methylumbelliferil-N-acetyl-beta-glucosamine (4-MUG), and the DNA-based analysis involves testing for the presence of specific known mutations in the alpha-subunit gene of Hex A. Prenatal diagnosis of Tay-Sachs disease is accomplished within 24-48 h from sampling. The preferred strategy is to simultaneously carry out enzymatic analysis in the amniotic fluid supernatant or in chorionic villi and molecular DNA-based testing in an amniotic fluid cell-pellet or in chorionic villi.

  20. Perturbations of Kantowski-Sachs models with a cosmological constant

    CERN Document Server

    Keresztes, Zoltán; Bradley, Michael; Dunsby, Peter K S; Gergely, László Á

    2013-01-01

    We investigate perturbations of Kantowski-Sachs models with a positive cosmological constant, using the gauge invariant 1+3 and 1+1+2 covariant splits of spacetime together with a harmonic decomposition. The perturbations are assumed to be vorticity-free and of perfect fluid type, but otherwise include general scalar, vector and tensor modes. In this case the set of equations can be reduced to six evolution equations for six harmonic coefficients.

  1. Kantowski-Sachs Universes sourced by a Skyrme fluid

    CERN Document Server

    Parisi, Luca; Vilasi, Gaetano

    2014-01-01

    The Kantowski-Sachs cosmological model sourced by a Skyrme field and a cosmological constant is considered in the framework of General Relativity. Assuming a constant radial profile function for the hedgehog ansatz, the Skyrme contribution to Einstein equations is shown to be equivalent to an anisotropic fluid. Using dynamical system techniques, a qualitative analysis of the cosmological equations is presented. Physically interesting features of the model such as isotropization, bounce and recollapse are discussed.

  2. Modified Sachs's Model of Deformation of Polycrystalline Magnesium

    Science.gov (United States)

    Kesarev, A. G.; Vlasova, A. M.

    2017-09-01

    There are a large number of approaches to a description of work hardening of metal polycrystals with various crystal lattices. In the present work, Sachs's model is generalized to uniaxial tension/compression of polycrystalline magnesium with hexagonal densely packed crystal lattice. The tensile yield stress is estimated taking into account two deformation modes: (0001) easy basal slip and (10\\overline{1}2) twinning.

  3. Julius H. Comroe, Jr., distinguished lecture: central chemoreception: then ... and now.

    Science.gov (United States)

    Nattie, Eugene

    2011-01-01

    The 2010 Julius H. Comroe, Jr., Lecture of the American Physiological Society focuses on evolving ideas in chemoreception for CO₂/pH in terms of what is "sensed," where it is sensed, and how the sensed information is used physiologically. Chemoreception is viewed as involving neurons (and glia) at many sites within the hindbrain, including, but not limited to, the retrotrapezoid nucleus, the medullary raphe, the locus ceruleus, the nucleus tractus solitarius, the lateral hypothalamus (orexin neurons), and the caudal ventrolateral medulla. Central chemoreception also has an important nonadditive interaction with afferent information arising at the carotid body. While ventilation has been viewed as the primary output variable, it appears that airway resistance, arousal, and blood pressure can also be significantly affected. Emphasis is placed on the importance of data derived from studies performed in the absence of anesthesia.

  4. Julius Elster and Hans Geitel - Dioscuri of physics and pioneer investigators in atmospheric electricity

    Science.gov (United States)

    Fricke, Rudolf G. A.; Schlegel, Kristian

    2017-01-01

    Julius Elster and Hans Geitel contributed to the physics at the turn of the 19-20th century in many ways. We first summarize the life of these exceptional scientists. Then - owing to the topic of this journal - we focus on their atmospheric electricity research. With their experiments, careful evaluations and ingenious interpretation, Elster and Geitel made important contributions to precipitation electricity, the influence of solar radiation on the electric state of the atmosphere, the nature of charge carriers and the ionization of air by radioactivity. They proved their experimental skills by inventing new instruments with unprecedented accuracy and reliability. A very modern concept was their attitude to undertake long-term measurements at various locations. A section on their recognition in the physics community and their scientific distinctions concludes the paper.

  5. Scripture in the Sky: Jeremias Drexel, Julius Schiller, and the Christianizing of the Constellations

    Science.gov (United States)

    Mendillo, M.; Shapiro, A.

    2011-06-01

    From the times of early Christians up to the Enlightenment, the twelve ancient signs of the zodiac were challenged as highly inappropriate pagan images. The most concerted efforts to replace those signs with names, mottos, and images taken from Holy Scripture occurred in the early decades of the 17th century. We review the background that led to the proposed use of sacred mottos by Jeremias Drexel, and then of the names and images of the Twelve Apostles by Julius Schiller. The reaction of a leading seventeenth-century astronomer is presented to suggest why such changes were never adopted. Finally, we address issues of conflict and motivation that might have led to efforts to Christianize the Heavens.

  6. Atmosphere-Ionosphere Coupling due to Atmospheric Tides (Julius Bartels Medal Lecture)

    Science.gov (United States)

    Forbes, Jeffrey M.

    2016-04-01

    Within the last decade, a new realization has arrived on the scene of ionosphere-thermosphere (IT) science: terrestrial weather significantly influences space weather. The aspect of space weather referred to here consists of electron density variability that translates to uncertainties in navigation and communications systems, and neutral density variability that translates to uncertainties in orbital and reentry predictions. In the present context "terrestrial weather" primarily refers to the meteorological conditions that determine the spatial-temporal distribution of tropospheric water vapor and latent heating associated with tropical convection, and the middle atmosphere disturbances associated with sudden stratosphere warmings. The net effect of these processes is a spatially- and temporally-evolving spectrum of waves (gravity waves, tides, planetary waves, Kelvin waves) that grows in amplitude with height and enters the IT system near ~100 km. Some members of the wave spectrum penetrate all the way to the base of the exosphere (ca. 500 km). Along the way, nonlinear interactions between different wave components occur, modifying the interacting waves and giving rise to secondary waves. Finally, the IT wind perturbations carried by the waves can redistribute ionospheric plasma, either through the electric fields generated via the dynamo mechanism between 100 and 150 km, or directly by moving plasma along magnetic field lines at higher levels. Additionally, the signatures of wave-driven dynamo currents are reflected in magnetic perturbations observed at the ground. This is how terrestrial atmospheric variability, through the spectrum of vertically- propagating waves that it produces, can effectively drive IT space weather. The primary objective of this Julius Bartels Lecture is to provide an overview of the global observational evidence for the IT consequences of these upward-propagating waves. In honor of Julius Bartels, who performed much research (including

  7. Early Conquest of the Rock: Julius Lempert's Life and the Complete Apicectomy Technique for the Treatment of Suppurative Petrous Apicitis

    OpenAIRE

    Khaled M. Krisht; Shelton, Clough; Couldwell, William T.

    2014-01-01

    Julius Lempert (1891–1968) was one of the most revolutionary and innovative neuro-otologists of the 20th century. He had a remarkable role in advancing the field of otolaryngology to its modern shape and form, especially through his groundbreaking introduction of the fenestration procedure for the treatment of otosclerosis. Although he is highly celebrated by many neuro-otologists for his contributions to our surgical and anatomical understanding of the petrous bone, he is not well known to t...

  8. von Neumann Morgenstern Preferences

    DEFF Research Database (Denmark)

    Vind, Karl

    von Neumann Morgenstern utility is generalized to von Neumann Morgenstern preferences. The proof is an application of simple hyperplane theorems......von Neumann Morgenstern utility is generalized to von Neumann Morgenstern preferences. The proof is an application of simple hyperplane theorems...

  9. von Neumann Morgenstern Preferences

    DEFF Research Database (Denmark)

    Vind, Karl

    2000-01-01

    von Neumann Morgenstern utility is generalized to von Neumann Morgenstern preferences. The proof is an application of simple hyperplane theorems......von Neumann Morgenstern utility is generalized to von Neumann Morgenstern preferences. The proof is an application of simple hyperplane theorems...

  10. Unitary evolution for a quantum Kantowski-Sachs cosmology

    CERN Document Server

    Pal, Sridip

    2015-01-01

    It is shown that like Bianchi I, V and IX models, a Kantowski-Sachs cosmological model also allows a unitary evolution on quantization. It has also been shown that this unitarity is not at the expense of the anisotropy. Non-unitarity, if there is any, cannot escape notice in this as the evolution is studied against a properly oriented time parameter fixed by the evolution of the fluid. Furthermore, we have constructed a wave-packet by superposing different energy eigenstates, thereby establishing unitarity in a non-trivial way, which is a stronger result than an energy eigenstate trivially giving time independent probability density. For $\\alpha\

  11. No bounce behaviour in Kantowski-Sachs Cosmologies

    CERN Document Server

    Solomons, D M; Ellis, G; Solomons, Deon; Dunsby, Peter; Ellis, George

    2001-01-01

    Many cosmological scenarios envisage either a bounce of the universe at early times, or collapse of matter locally to form a black hole which re-expands into a new expanding universe region. Energy conditions preclude this happening for ordinary matter in general relativistic universes, but scalar or dilatonic fields can violate some of these conditions, and so could possibly provide bounce behaviour. In this paper we show that such bounces cannot occur in Kantowski-Sachs models without violating the {\\it reality condition} $\\dot{\\phi}^2\\geq 0$.

  12. Testing cosmological models with the Integrated Sachs-Wolfe effect

    Energy Technology Data Exchange (ETDEWEB)

    Raccanelli, Alvise, E-mail: alvise.raccanelli@port.ac.uk [Institute of Cosmology and Gravitation, University of Portsmouth, Dennis Sciama Building, Portsmouth, PO1 3FX (United Kingdom)

    2011-02-01

    The cross correlation between the Cosmic Microwave Background and the Large Scale Structure of the Universe is a powerful probe to test our cosmological models. This correlation can be used to detect the Integrated Sachs-Wolfe effect, and it depends on both the geometry of the Universe and the properties of the clustering and evolution of structures; for this reason it can be used to test and constrain cosmological models and parameters as well as theories of gravity. In this proceeding we briefly introduce the ISW effect and present some of the recent cosmological tests done using it.

  13. Rapid identification of HEXA mutations in Tay-Sachs patients.

    Science.gov (United States)

    Giraud, Carole; Dussau, Jeanne; Azouguene, Emilie; Feillet, François; Puech, Jean-Philippe; Caillaud, Catherine

    2010-02-19

    Tay-Sachs disease (TSD) is a recessively inherited neurodegenerative disorder due to mutations in the HEXA gene resulting in a beta-hexosaminidase A (Hex A) deficiency. The purpose of this study was to characterize the molecular abnormalities in patients with infantile or later-onset forms of the disease. The complete sequencing of the 14 exons and flanking regions of the HEXA gene was performed with a unique technical condition in 10 unrelated TSD patients. Eleven mutations were identified, including five splice mutations, one insertion, two deletions and three single-base substitutions. Four mutations were novel: two splice mutations (IVS8+5G>A, IVS2+4delAGTA), one missense mutation in exon 6 (c.621T>G (p.D207E)) and one small deletion (c.1211-1212delTG) in exon 11 resulting in a premature stop codon at residue 429. The c.621T>G missense mutation was found in a patient presenting an infantile form. Its putative role in the pathogenesis of TSD is suspected as residue 207 is highly conserved in human, mouse and rat. Moreover, structural modelling predicted changes likely to affect substrate binding and catalytic activity of the enzyme. The time-saving procedure reported here could be useful for the characterization of Tay-Sachs-causing mutations, in particular in non-Ashkenazi patients mainly exhibiting rare mutations.

  14. Julius König et les Principes Aristotéliciens

    Directory of Open Access Journals (Sweden)

    Marcel Guillaume

    2009-08-01

    Full Text Available In his posthumous book from 1914, “New foundations of logic, arithmetic andset theory”, Julius König develops his philosophy of mathematics. In a previous contribution, we attracted attention on the positive part (his truth and falsehood predicates being excluded of his “pure logic”: his “isology” being assimilated to mutual implication, it constitutes a genuine formalization of positive intuitionistic logic. König’s intention was to rebuild logic in such a way that the excluded third’s principle could no longer be logical. However, his treatment of truth and falsehood (boiling down to negation is purely classical. We explain here this discrepancy by the choice of the alleged more primitive notions to which the questioned notions of truth and falsehood have been reduced. Finaly, it turns out that the disjunctive and conjunctive forms of the principles of the excluded third and of contradiction have effectively been excluded, but none of their implicative forms.

  15. VERBAL POWER DUEL: VERBAL COMBAT STRATEGIES IN SHAKESPEARE'S JULIUS CAESAR:BRUTUS VERSUS ANTONY

    Directory of Open Access Journals (Sweden)

    AYDIN BEHNAM

    2009-01-01

    Full Text Available In A Glossary of Contemporary Literary Theory, Jeremy Hawthorn refers to Cultural Materialism as an "umbrella term" that allows itself the opulence to utilise a wide range of tools and theories from many different disciplines. This allows us to justify the nature of both commonly acknowledged and abstruse socio-cultural episteme and discourse, one of the most prominent of which is the issue of power and power relations.This paper, which was originally part of a larger body of work on Cultural Materialism, tries to draw upon a few different theories to examine the confrontational relationship that exists between the two prominent characters of Shakespeare's (1953 Julius Caesar (namely Antony and Brutus, as represented by the duel-like orations of the two characters. The main goal of the paper is to demonstrate how Antony is able to manipulate the words of Brutus against him and thus succeed in captivating the crowd.The theoretical discussions drawn upon in this article will include Austin's (1999 ideas on language as action, Bourdieu's (1999 argument of dialogue as contest and Hutchby's (1999 findings on turn-taking strategies. This paper will also incorporate Paul Grice's Cooperative Principle, introduced in his "Logic and Conversation" (1999. This principle argues that the flouting of any of Grice's four maxims by the characters is meaningful and effective because it introduces an "implicature" in the political and social context in which the pieces of discourse take place.

  16. Dictator Perpetuus: Julius Caesar--did he have seizures? If so, what was the etiology?

    Science.gov (United States)

    Hughes, John R

    2004-10-01

    The "Dictator Perpetuus" of the Roman Empire, the great Julius Caesar, was not the one for whom the well-known cesarean operation was named; instead, this term is derived from a Latin word meaning "to cut." Caesar likely had epilepsy on the basis of four attacks that were probably complex partial seizures: (1) while listening to an oration by Cicero, (2) in the Senate while being offered the Emperor's Crown, and in military campaigns, (3) near Thapsus (North Africa) and (4) Corduba (Spain). Also, it is possible that he had absence attacks as a child and as a teenager. His son, Caesarion, by Queen Cleopatra, likely had seizures as a child, but the evidence is only suggestive. His great-great-great grandnephews Caligula and Britannicus also had seizures. The etiology of these seizures in this Julio-Claudian family was most likely through inheritance, with the possibility of sudden unexpected death in epilepsy (SUDEP) in his great grandfather and also his father. Our best evidence comes from the ancient sources of Suetonius, Plutarch, Pliny, and Appianus.

  17. Rhetorical Flaws in Brutus’ Forum Speech in Julius Caesar: A Carefully Controlled Weakness?

    Directory of Open Access Journals (Sweden)

    Dominic Cheetham

    2017-06-01

    Full Text Available In Julius Caesar Shakespeare reproduces one of the pivotal moments in European history. Brutus and Mark Antony, through the medium of their forum speeches, compete for the support of the people of Rome. In the play, as in history, Mark Antony wins this contest of language. Critics are generally agreed that Antony has the better speech, but also that Brutus’ speech is still exceptionally good. Traditionally the question of how Antony’s speech is superior is argued by examining differences between the two speeches, however, this approach has not resulted in any critical consensus. This paper takes the opening lines of the speeches as the only point of direct convergence between the content and the rhetorical forms used by Brutus and Antony and argues that Brutus’ opening tricolon is structurally inferior to Marc Antony’s. Analysis of the following rhetorical schemes in Brutus’ speech reveals further structural weaknesses. Shakespeare gives Brutus a speech rich in perceptually salient rhetorical schemes but introduces small, less salient, structural weaknesses into those schemes. The tightly structured linguistic patterns which make up the majority of Brutus’ speech give an impression of great rhetorical skill. This skilful impression obscures the minor faults or weaknesses that quietly and subtly reduce the overall power of the speech. By identifying the weaknesses in Brutus’ forms we add an extra element to the discussion of these speeches and at the same time display how subtly and effectively Shakespeare uses rhetorical forms to control audience response and appreciation.

  18. Structural consequences of amino acid substitutions causing Tay-Sachs disease.

    Science.gov (United States)

    Ohno, Kazuki; Saito, Seiji; Sugawara, Kanako; Sakuraba, Hitoshi

    2008-08-01

    To determine the structural changes in the alpha-subunit of beta-hexosaminidase due to amino acid substitutions causing Tay-Sachs disease, we built structural models of mutant alpha-subunits resulting from 33 missense mutations (24 infantile and 9 late-onset), and analyzed the influence of each amino acid replacement on the structure by calculating the number of atoms affected and determining the solvent-accessible surface area of the corresponding amino acid residue in the wild-type alpha-subunit. In the infantile Tay-Sachs group, the number of atoms influenced by a mutation was generally larger than that in the late-onset Tay-Sachs group in both the main chain and the side chain, and residues associated with the mutations found in the infantile Tay-Sachs group tended to be less solvent-accessible than those in the late-onset Tay-Sachs group. Furthermore, color imaging determined the distribution and degree of the structural changes caused by representative amino acid substitutions, and that there were also differences between the infantile and late-onset Tay-Sachs disease groups. Structural study is useful for elucidating the basis of Tay-Sachs disease.

  19. Comparison of the Sachs-Wolfe Effect for Gaussian and Non-Gaussian Fluctuations

    CERN Document Server

    Kung, J H

    1993-01-01

    A consequence of non-Gaussian perturbations on the Sachs-Wolfe effect is studied. For a particular power spectrum, predicted Sachs-Wolfe effects are calculated for two cases: Gaussian (random phase) configuration, and a specific kind of non-Gaussian configuration. We obtain a result that the Sachs-Wolfe effect for the latter case is smaller when each temperature fluctuation is properly normalized with respect to the corresponding mass fluctuation ${\\delta M\\over M}(R)$. The physical explanation and the generality of the result are discussed.

  20. Conserved charges of the extended Bondi-Metzner-Sachs group

    CERN Document Server

    Flanagan, Eanna E

    2015-01-01

    Isolated objects in asymptotically flat spacetimes in general relativity are characterized by their conserved charges associated with the Bondi-Metzner-Sachs (BMS) group. These charges include total energy, linear momentum, intrinsic angular momentum and center-of-mass location, and in addition an infinite number of supermomentum charges associated with supertranslations. Recently it has been suggested that the BMS symmetry algebra should be enlarged to include an infinite number of additional symmetries known as superrotations. We compute the corresponding "super center-of-mass'' charges and show that they are finite and well defined. The supermomentum charges are associated with ordinary gravitational wave memory, and the super center-of-mass charges are associated with total (ordinary plus null) gravitational wave memory, in the terminology of Bieri and Garfinkle. Some of these charges can give rise to black hole hair, as described by Strominger and Zhiboedov. We clarify how this hair evades the no hair th...

  1. Planck 2015 results: XXI. The integrated Sachs-Wolfe effect

    DEFF Research Database (Denmark)

    Ade, P. A R; Aghanim, N.; Arnaud, M.

    2016-01-01

    This paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives....... The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ...... scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features...

  2. Numerical Relativity and the Bondi-Metzner-Sachs Group

    Science.gov (United States)

    Winicour, Jeffrey

    2017-01-01

    There are interesting phenomena associated with the Bondi-Metzner-Sachs (BMS) group that deserve numerical exploration. The BMS group, which is the asymptotic symmetry group of an isolated gravitational system, extends the Poincare group by the addition of an infinite set of supertranslations parameterized by a function on the sphere α(θ , ϕ) . The l = 0 and l = 1 spherical harmonics invariantly pick out the time and space translations, which leads to an unambiguous definition of energy and momentum. However, a Poincare subgroup cannot be invariantly defined, which leads to a supertranslation ambiguity in the definition of angular momentum. This opens the possibility of a purely general relativistic mechanism for angular momentum loss. The supertranslations are also associated with the gravitational memory effect. I will discuss these problems which are ripe for the numerical simulation of high spin black hole binaries. Supported by NSF grant PHY-1505965 to the University of Pittsburgh.

  3. Tay-Sachs disease: current perspectives from Australia.

    Science.gov (United States)

    Lew, Raelia M; Burnett, Leslie; Proos, Anné L; Delatycki, Martin B

    2015-01-01

    Tay-Sachs disease (TSD) is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years.

  4. Atypical presentation of late-onset Tay-Sachs disease.

    Science.gov (United States)

    Deik, Andres; Saunders-Pullman, Rachel

    2014-05-01

    Late-onset Tay-Sachs disease (LOTS) is a lysosomal storage disease caused by deficient Beta-hexosaminidase A activity. We describe a 53-year-old woman who presented with adult-onset leg weakness, and whose initial diagnosis was progressive muscular atrophy without identifiable etiology. Development of cerebellar ataxia in mid-life prompted reassessment. Beta-hexosaminidase A quantification assay demonstrated absence of the isozyme. Genetic testing identified compound heterozygous mutations in the HEXA gene, confirming the diagnosis of LOTS. The phenotypic spectrum of LOTS includes motor neuronopathy, ataxia, choreoathetosis, neuropathy, and psychiatric symptoms in various combinations. This patient highlights the emergence of different clinical features over many years and emphasizes the need to consider LOTS in the differential diagnosis of progressive muscular atrophy. Copyright © 2013 Wiley Periodicals, Inc.

  5. Bounce behaviour in Kantowski-Sachs and Bianchi cosmologies

    Energy Technology Data Exchange (ETDEWEB)

    Solomons, Deon [Cape Peninsula University of Technology, Cape Town (South Africa); Dunsby, Peter K S [Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch 7701, Cape Town (South Africa); Ellis, George F R [Department of Mathematics and Applied Mathematics, University of Cape Town, Rondebosch 7701, Cape Town (South Africa)

    2006-12-07

    Many cosmological scenarios envisage either a bounce of the universe at early times, or collapse of matter locally to form a black hole which re-expands into a new expanding universe region. Energy conditions preclude this happening for ordinary matter in general relativistic universes, but scalar or dilatonic fields can violate some of these conditions, and so could possibly provide bounce behaviour. In this paper we show that such bounces cannot occur in Kantowski-Sachs models without violating the reality condition {phi}-dot{sup 2} {>=}0. This also holds true for other isotropic spatially homogeneous Bianchi models, with the exception of closed Friedmann-Robertson-Walker and Bianchi IX models; bounce behaviour violates the weak energy condition {rho} {>=} 0 and {rho} + p {>=} 0. We turn to the Randall-Sundrum type braneworld scenario for a possible resolution of this problem.

  6. Planck 2013 results. XIX. The integrated Sachs-Wolfe effect

    DEFF Research Database (Denmark)

    Ade, P. A. R.; Aghanim, N.; Armitage-Caplan, C.

    2014-01-01

    Based on cosmic microwave background (CMB) maps from the 2013 Planck Mission data release, this paper presents the detection of the integrated Sachs-Wolfe (ISW) effect, that is, the correlation between the CMB and large-scale evolving gravitational potentials. The significance of detection ranges...... from 2 to 4σ, depending on which method is used. We investigated three separate approaches, which essentially cover all previous studies, and also break new ground. (i) We correlated the CMB with the Planck reconstructed gravitational lensing potential (for the first time). This detection was made...... on a combination of radio (NVSS) and optical (SDSS) data. (iii) We used aperture photometry on stacked CMB fields at the locations of known large-scale structures, which yielded and confirms a 4σ signal, over a broader spectral range, when using a previously explored catalogue, but shows strong discrepancies...

  7. Non-Canonical Phase-Space Noncommutativity and the Kantowski-Sachs singularity for Black Holes

    CERN Document Server

    Bastos, Catarina; Dias, Nuno Costa; Prata, João Nuno

    2010-01-01

    We consider a cosmological model based upon a non-canonical noncommutative extension of the Heisenberg-Weyl algebra to address the thermodynamical stability and the singularity problem of both the Schwarzschild and the Kantowski-Sachs black holes. The interior of the black hole is modelled by a noncommutative extension of the Wheeler-DeWitt equation. We compute the temperature and entropy of a Kantowski-Sachs black hole and compare our results with the Hawking values. Again, the noncommutativity in the momenta sector allows us to have a minimum in the potential, which is relevant in order to apply the Feynman-Hibbs procedure. For Kantowski-Sachs black holes, the same model is shown to generate a non-unitary dynamics, predicting vanishing total probability in the neighborhood of the singularity. This result effectively regularizes the Kantowski-Sachs singularity and generalizes a similar result, previously obtained for the case of Schwarzschild black hole.

  8. Tay-Sachs disease: current perspectives from Australia

    Directory of Open Access Journals (Sweden)

    Lew RM

    2015-01-01

    Full Text Available Raelia M Lew,1,7 Leslie Burnett,2,3,4 Anné L Proos,2 Martin B Delatycki5,6 1Department of Obstetrics and Gynecology, QEII Research Institute for Mothers and Infants, The University of Sydney, Australia; 2NSW Health Pathology North, Royal North Shore Hospital, St Leonards, Australia; 3SEALS, Prince of Wales Hospital, Randwick, Australia; 4Sydney Medical School-Northern, Royal North Shore Hospital E25, University of Sydney, Sydney, Australia; 5Department of Clinical Genetics, Austin Health, Heidelberg, Australia; 6Bruce Lefroy Centre for Genetic Health Research, Murdoch Childrens Research Institute, Parkville, Australia; 7Department of Obstetrics and Gynaecology, Dentistry and Health Sciences, Faculty of Medicine, The University of Melbourne, Melbourne, Australia Abstract: Tay-Sachs disease (TSD is a fatal, recessively inherited neurodegenerative condition of infancy and early childhood. Although rare in most other populations, the carrier frequency is one in 25 in Ashkenazi Jews. Australian high-school-based TSD preconception genetic screening programs aim to screen, educate, and optimize reproductive choice for participants. These programs have demonstrated high uptake, low psychological morbidity, and have been shown to result in fewer than expected Jewish TSD-affected births over 18 years of operation. The majority of Jewish individuals of reproductive age outside of the high school screening program setting in Australia have not accessed screening. Recent recommendations advocate supplementing the community high school screening programs with general practitioner- and obstetrician-led genetic screening of Ashkenazi Jewish individuals for TSD and other severe recessive diseases for which this group is at risk. Massively parallel DNA sequencing is expected to become the testing modality of choice over the coming years. Keywords: Tay-Sachs disease, genetic screening, Australia

  9. Tay-Sach disease with "cherry-red spot"--first reported case in Malaysia.

    Science.gov (United States)

    Chan, L Y; Balasubramaniam, S; Sunder, R; Jamalia, R; Karunakar, T V N; Alagaratnam, J

    2011-12-01

    We present a rare case of Tay-Sachs disease with retinal 'cherry-red spots' in a 19-month-old Malay child. Molecular genetic studies confirmed the diagnosis. The case highlights that 'cherry-red spot' is a useful clinical clue in Tay-Sachs disease and several other lysosomal storage disorders. It serves as an ideal illustration of the eye as a window to inborn error of metabolism.

  10. [Julius Ludwig August Koch (1841-1908). Psychiatrist, philosopher, and Christian].

    Science.gov (United States)

    Gutmann, Philipp

    2006-01-01

    Julius Ludwig August Koch was born 1841 in the small town of Laichingen (Württemberg) in the Southwest of Germany. After working as a chemist for about seven years, he studied medicine in Tübingen from 1863 to 1867. First he worked as a physican and later in a private mental hospital in Göppingen. From 1874 to 1898, he was director of a state mental hospital in Zwiefalten (Württemberg). Koch died in 1908 after a long period of suffering in Zwiefalten. Being deeply routed in a Christian faith and having much interest in moral and ethical issues, Koch published some philosophical works 'Epistomological investigations' (Erkenntnistheoretische Untersuchungen, 1882), 'Outline of philosophy' (Grundriss der Philosophie, 1885) and 'Reality and its knowledge' (Die Wirklichkeit und ihre Erkenntnis, 1886). In this papers he tried to bring together critical Kantian philosophy and Christian conviction. In 1888 he published a 'Short Textbook of Psychiatry' (Kurzgefasster Leitfaden der Psychiatrie), where he mentioned the term "psychopathic inferiority" for the first time (Psychopathische Minderwertigkeiten). The following work, focussing on this issue with the title 'Psychopathic Inferiority' (Die psychopathischen Minderwertigkeiten, 1891-1893), became one of the fundamental texts concerning the concept of disorders of personality, which are in use today. In this book, published in three parts, he tried to describe the hole field between psychic normality and psychoses. Only the first and biggest part deals with psychopathological symptoms which we now think to be essential for personality disorders. Koch differentiates between "disposition" (Disposition), "burden" (Belastung) and "degeneration" (Degeneration), assuming a graduation. "Disposition" should be the mildest disorder, turning into normality, whereas "degeneration" turns to psychosis. Koch believed, that on the basis of all degrees of "psychpathic inferiority" there was a congenital defect of the constitution of

  11. Odonaten von Sumatra, gesammelt von Edward Jacobson

    NARCIS (Netherlands)

    Ris, F.

    1927-01-01

    Die folgende Bearbeitung sumatranischer Libellen schliesst sich an zwei frühere Aufsätze über Libellen von Java und von Simalur an, die mir Herr Jacobson anvertraute. Die hier beschriebene wesentlich grössere Sammlung aus den Jahren 1913—15 kam gegen Ende 1920 in meine Hände, sie hätte also längst e

  12. Correlation between Bankart and Hill-Sachs lesions in anterior shoulder dislocation.

    Science.gov (United States)

    Widjaja, Audi B; Tran, Anh; Bailey, Michael; Proper, Stewart

    2006-06-01

    Bankart lesions and Hill-Sachs lesions are commonly associated with anterior shoulder dislocations. The presence of Bankart lesion indicates the need for surgical repair. Magnetic resonance imaging (MRI) has been shown to be sensitive in detecting these two lesions. The aim of this study is to investigate the correlation between Bankart lesions and Hill-Sachs lesions on MRI for patients with traumatic anterior shoulder dislocations. Between 2003 and 2005, 61 patients from Alfred and Sandringham Hospitals had an MRI as part of the investigation for traumatic anterior shoulder dislocations. The MRI scans were reviewed and subsequently confirmed by a radiologist to show the presence or absence of Bankart and Hill-Sachs lesions. The data were then analysed by a statistician. Although patients with one of these lesions were more than two-and-a-half times as likely to have the other, small study numbers precluded this result from achieving statistical significance. (odds ratio, 2.67 (0.83-8.61), P = 0.10). Younger age was a strong predictor of a recurrence of shoulder dislocation (odds ratio, 0.93 (0.89-0.98), P = 0.005). The presence of Bankart or Hill-Sachs lesions on MRI for the primary shoulder dislocation group was similar to the recurrent group (73% vs. 72% for Bankart lesion and 67% vs. 70% for Hill-Sachs lesion). There is a strong correlation between both lesions. This apparent trend can be useful in predicting the presence of a Bankart lesion when a Hill-Sachs lesion is identified on a plain radiograph. This study suggests the consideration of surgical repair after identification of a Hill-Sachs lesion on plain radiographs, especially for younger patients where the rate of re-dislocation is high.

  13. Kantowski-Sachs Einstein-aether perfect fluid models

    CERN Document Server

    Latta, Joey

    2016-01-01

    We investigate Kantowski-Sachs models in Einstein-aether theory with a perfect fluid source using dynamical system tools. We find an inflationary source at early times, and an inflationary sink at late times, for a wide region in the parameter space. The results by A. A. Coley, G. Leon, P. Sandin and J. Latta, JCAP {\\bf 12}, 010 (2015) are then re-obtained as particular cases. Additionally, we select other values for non-GR parameters which are consistent with current constraints, getting a very rich phenomenology. Particularly, we find solutions with infinite shearing, zero curvature, and infinity matter energy density in comparison with the Hubble scalar. We also have stiff-like future attractors, anisotropic late-time attractors, or both, in some special cases. Such results are developed analytically, and then verified by numerics. From the cosmological point of view, the more interesting fixed points are those representing accelerated solutions. However, the accelerated solutions do not isotropize, and th...

  14. Integrated Sachs-Wolfe effect in massive bigravity

    CERN Document Server

    Enander, Jonas; Mortsell, Edvard; Renneby, Malin; Solomon, Adam R

    2015-01-01

    We study the Integrated Sachs-Wolfe (ISW) effect in ghost-free, massive bigravity, where only one metric couples to matter. We focus on the infinite-branch bigravity (IBB) model which exhibits viable cosmic expansion histories and stable linear perturbations, while the cosmological constant is set to zero and the late-time accelerated expansion of the Universe is due solely to the gravitational interaction terms. The ISW contribution to the CMB auto-correlation power spectrum is predicted, as well as the cross-correlation between the CMB temperature anisotropies and the large-scale structure. We use ISW amplitudes as observed in the WMAP 9-year temperature data together with galaxy and AGN data provided by the WISE mission, in order to compare the theoretical predictions to the observations. The ISW amplitudes in IBB are found to be larger than the corresponding ones in the standard LCDM model by roughly a factor of 1.5, but are still consistent with the observations.

  15. The High Redshift Integrated Sachs-Wolfe Effect

    CERN Document Server

    Xia, Jun-Qing; Baccigalupi, Carlo; Matarrese, Sabino

    2009-01-01

    In this paper we rely on the quasar (QSO) catalog of the Sloan Digital Sky Survey Data Release Six (SDSS DR6) of about one million photometrically selected QSOs to compute the Integrated Sachs-Wolfe (ISW) effect at high redshift, aiming at constraining the behavior of the expansion rate and thus the behaviour of dark energy at those epochs. This unique sample significantly extends previous catalogs to higher redshifts while retaining high efficiency in the selection algorithm. We compute the auto-correlation function (ACF) of QSO number density from which we extract the bias and the stellar contamination. We then calculate the cross-correlation function (CCF) between QSO number density and Cosmic Microwave Background (CMB) temperature fluctuations in different subsamples: at high z>1.5 and low z1.5. We focus on the capabilities of the ISW to constrain the behaviour of the dark energy component at high redshift both in the \\LambdaCDM and Early Dark Energy cosmologies, when the dark energy is substantially unco...

  16. Reconstructing the integrated Sachs-Wolfe map with galaxy surveys

    Science.gov (United States)

    Muir, Jessica; Huterer, Dragan

    2016-08-01

    The integrated Sachs-Wolfe (ISW) effect is a large-angle modulation of the cosmic microwave background (CMB), generated when CMB photons traverse evolving potential wells associated with large scale structure (LSS). Recent efforts have been made to reconstruct maps of the ISW signal using information from surveys of galaxies and other LSS tracers, but investigation into how survey systematics affect their reliability has so far been limited. Using simulated ISW and LSS maps, we study the impact of galaxy survey properties and systematic errors on the accuracy of a reconstructed ISW signal. We find that systematics that affect the observed distribution of galaxies along the line of sight, such as photo-z and bias-evolution related errors, have a relatively minor impact on reconstruction quality. In contrast, however, we find that direction-dependent calibration errors can be very harmful. Specifically, we find that, in order to avoid significant degradation of our reconstruction quality statistics, direction-dependent number density fluctuations due to systematics must be controlled so that their variance is smaller than 10-6 (which corresponds to a 0.1% calibration). Additionally, we explore the implications of our results for attempts to use reconstructed ISW maps to shed light on the origin of large-angle CMB alignments. We find that there is only a weak correlation between the true and reconstructed angular momentum dispersion, which quantifies alignment, even for reconstructed ISW maps which are fairly accurate overall.

  17. Kantowski-Sachs Einstein-æther perfect fluid models

    Science.gov (United States)

    Latta, Joey; Leon, Genly; Paliathanasis, Andronikos

    2016-11-01

    We investigate Kantowski-Sachs models in Einstein-æ ther theory with a perfect fluid source using the singularity analysis to prove the integrability of the field equations and dynamical system tools to study the evolution. We find an inflationary source at early times, and an inflationary sink at late times, for a wide region in the parameter space. The results by A.A. Coley, G. Leon, P. Sandin and J. Latta (JCAP 12 (2015) 010), are then re-obtained as particular cases. Additionally, we select other values for the non-GR parameters which are consistent with current constraints, getting a very rich phenomenology. In particular, we find solutions with infinite shear, zero curvature, and infinite matter energy density in comparison with the Hubble scalar. We also have stiff-like future attractors, anisotropic late-time attractors, or both, in some special cases. Such results are developed analytically, and then verified by numerics. Finally, the physical interpretation of the new critical points is discussed.

  18. Conserved charges of the extended Bondi-Metzner-Sachs algebra

    Science.gov (United States)

    Flanagan, Éanna É.; Nichols, David A.

    2017-02-01

    Isolated objects in asymptotically flat spacetimes in general relativity are characterized by their conserved charges associated with the Bondi-Metzner-Sachs (BMS) group. These charges include total energy, linear momentum, intrinsic angular momentum and center-of-mass location, and, in addition, an infinite number of supermomentum charges associated with supertranslations. Recently, it has been suggested that the BMS symmetry algebra should be enlarged to include an infinite number of additional symmetries known as super-rotations. We show that the corresponding charges are finite and well defined, and can be divided into electric parity "super center-of-mass" charges and magnetic parity "superspin" charges. The supermomentum charges are associated with ordinary gravitational-wave memory, and the super center-of-mass charges are associated with total (ordinary plus null) gravitational-wave memory, in the terminology of Bieri and Garfinkle. Superspin charges are associated with the ordinary piece of spin memory. Some of these charges can give rise to black hole hair, as described by Strominger and Zhiboedov. We clarify how this hair evades the no-hair theorems.

  19. Rheologie von Beschichtungen

    Science.gov (United States)

    Schäffler, Michael

    Die Rheologie beschreibt die Fließ- und Deformationseigenschaften von Materialien. Der Begriff Rheologie ist aus dem Griechischen abgeleitet: rhein - fließen. Erst im Jahre 1930 entwickelte E.C. Bingham und M. Reiner in Easton (USA) die Rheologie zu einer eigenständigen Wissenschaft. Aber bereits seit dem 17. Jahrhundert wurden wesentliche Einzelbeiträge zu Fließphänomenen veröffentlich, so z.B. 1676 von R. Hooke (Hookesches Gesetz) und 1687 von I. Newton (Newtonsches Gesetz). Die Rheologie hat sich bis heute immer mehr zu einer interdisziplinären Wissenschaft entwickelt, die die mechanischen Eigenschaften von Materialien charakterisiert.

  20. [Tay-Sachs disease in non-Jewish infant in Israel].

    Science.gov (United States)

    Nadim, Nasser

    2012-01-01

    Tay-Sachs disease, also known as GM2 gangliosidosis or Hexosaminidase A deficiency is an autosomal recessive genetic fatal disorder. The disease is known to appear in East European Ashkenazi Jews, North African Jews, and Quebec French Canadians exclusively, but, with different frequency and type of mutation. Its most common variant is the infantile type Tay-Sachs disease. Juvenile and late-onset forms of the disease are infrequent and slowly progressive. At nearly 3 to 6 months old, a baby with Tay-Sachs progressively loses his motor skills and attentiveness. Startle responses and hyperreflexia become prominent, especially on eliciting deep patellar and Achilles reflexes, as a consequence of neurodegeneration of the upper motor neuron. Other systemic damage ensues gradually; seizures, blindness, spasticity of limbs, inability to swallow and breathe, and eventually the baby dies at 1-4 years of age. All Tay-Sachs patients have a "cherry red spot", easily seen in the macula area of the retina, using an ophthalmoscope. The "cherry red spot" is the only normal part of the retina in these sick babies. The case presented here emphasizes that Tay-Sachs disease is sometimes misdiagnosed at first visits even by an experienced clinician, because of his lack of awareness that this disease is not exclusively a Jewish disease.

  1. Hill-Sachs Off-track Lesions as Risk Factor for Recurrence of Instability After Arthroscopic Bankart Repair.

    Science.gov (United States)

    Locher, Joel; Wilken, Frauke; Beitzel, Knut; Buchmann, Stefan; Longo, Umile Giuseppe; Denaro, Vincenzo; Imhoff, Andreas B

    2016-10-01

    To evaluate the effect of "off-track" Hill-Sachs lesions, according to the glenoid track concept, as a risk factor for recurrent instability and need for revision surgery after arthroscopic Bankart repair. We retrospectively reviewed 254 patients with anteroinferior glenohumeral instability who were managed with an arthroscopic stabilization procedure between 2006 and 2013. Preoperative magnetic resonance imaging and/or computed tomography scans were available for 100 of these patients to calculate the glenoid track and the presence of "on-track" or off-track Hill-Sachs lesions. Recurrence of instability was evaluated at a mean follow-up of 22.4 months. Of 100 patients whose magnetic resonance imaging and/or computed tomography scans were available, 88 had an on-track Hill-Sachs lesion and 12 had an off-track Hill-Sachs lesion. Revision surgery for recurrent instability was performed in 5 patients (6%) with an on-track Hill-Sachs lesion and in 4 patients (33%) with an off-track Hill-Sachs lesion (odds ratio, 8.3; 95% confidence interval, 1.85-37.26; P = .006). An off-track Hill-Sachs lesion is a significant and important risk factor for recurrence of instability and need for revision surgery after arthroscopic Bankart repair when compared with an on-track Hill-Sachs lesion. Level IV, prognostic case series. Copyright © 2016 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.

  2. Bondi-Sachs energy-momentum and the energy of gravitational radiation

    CERN Document Server

    Maluf, J W; Ulhoa, S C

    2015-01-01

    We construct the gravitational energy-momentum of the Bondi-Sachs space-time, in the famework of the teleparallel equivalent of general relativity (TEGR). The Bondi-Sachs line element describes gravitational radiation in the asymptotic region of the space-time, and is determined by the mass aspect and by two functions, $c$ and $d$, that yield the news functions, which are interpreted as the radiating degrees of freedom of the gravitational field. The standard expression for the Bondi-Sachs energy-momentum is constructed in terms of the mass aspect only. The expression that we obtain in the context of the TEGR is given by the standard expression, which represents the gravitational energy of the source, plus a new term that is determined by the two functions $c$ and $d$. We interpret this new term as the energy of gravitational radiation.

  3. Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.

    Science.gov (United States)

    Kodama, Takashi; Togawa, Tadayasu; Tsukimura, Takahiro; Kawashima, Ikuo; Matsuoka, Kazuhiko; Kitakaze, Keisuke; Tsuji, Daisuke; Itoh, Kohji; Ishida, Yo-Ichi; Suzuki, Minoru; Suzuki, Toshihiro; Sakuraba, Hitoshi

    2011-01-01

    To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2) levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex) B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.

  4. Von Triers kristendom

    DEFF Research Database (Denmark)

    Søndergaard, Leif

    2009-01-01

    Lars von Trier er i hans film Antichrist i sin negation af kristendommen stærkt bundet til kristendommens dualistiske verdensbillede. Samtidig er filmen kvindefjendsk. Udgivelsesdato: 2. september......Lars von Trier er i hans film Antichrist i sin negation af kristendommen stærkt bundet til kristendommens dualistiske verdensbillede. Samtidig er filmen kvindefjendsk. Udgivelsesdato: 2. september...

  5. Planung von Hochschulbibliotheken - Tagungsbericht

    Directory of Open Access Journals (Sweden)

    Felicitas Hundhausen

    2015-07-01

    Full Text Available Am 18. November 2014 veranstalteten das HIS-Institut für Hochschulentwicklung und die beiden Herausgeber des "Handbuchs Hochschulbibliothekssysteme", Konstanze Söllner und Wilfried Sühl-Strohmenger, in Hannover eine Tagung zum Thema "Planung von Hochschulbibliotheken". Hier ging es um ausgewählte Aspekte der Planung und Steuerung von Hochschulbibliotheken.

  6. Oligocaene Gastropoden von Buton

    NARCIS (Netherlands)

    Martin, K.

    1935-01-01

    Vor einiger Zeit besehrieb ich eine kleine, eigenartige Molluskenfauna aus tertiären Asphaltkalken von der unbedeutenden Insel Buton, im Südosten von Celebes¹). Seither empfing Herr Prof. Ir. Chr. K. Visser in Delft weitere Versteinerungen aus den Asphaltkalken des Eilands, die nach ihm wahrscheinli

  7. Teleotemporalidad: un nivel de estudio adicional para la organización derivado del modelo de Julius Thomas Fraser

    Directory of Open Access Journals (Sweden)

    Claudio Mera Ruiz

    2016-02-01

    Full Text Available Este artículo propone la teleotemporalidad como un nuevo espacio de análisis de la organización derivado de la consideración del modelo de Julius Thomas Fraser. Para desarrollar la propuesta, se sintetiza el trabajo de Fraser, que está compuesto por seis niveles de estudio de la temporalidad: 1 atemporalidad, que toca los fenómenos electromagnéticos; 2 prototemporalidad, que explica el comportamiento molecular; 3 eotemporalidad, que se ocupa de la mecánica clásica; 4 biotemporalidad, que atañe al comportamiento de los seres vivos; 5 nootemporalidad, que explica la experiencia humana, y 6 sociotemporalidad, sobre los fenómenos sociales del tiempo. Por último, se explica la teleotemporalidad como un nuevo espacio de análisis útil para aproximarse a la comprensión de la temporalidad organizacional.

  8. Early Conquest of the Rock: Julius Lempert's Life and the Complete Apicectomy Technique for the Treatment of Suppurative Petrous Apicitis.

    Science.gov (United States)

    Krisht, Khaled M; Shelton, Clough; Couldwell, William T

    2015-03-01

    Julius Lempert (1891-1968) was one of the most revolutionary and innovative neuro-otologists of the 20th century. He had a remarkable role in advancing the field of otolaryngology to its modern shape and form, especially through his groundbreaking introduction of the fenestration procedure for the treatment of otosclerosis. Although he is highly celebrated by many neuro-otologists for his contributions to our surgical and anatomical understanding of the petrous bone, he is not well known to the neurosurgical community. In this article, we give a detailed account of Dr. Lempert's life and discuss his invaluable contribution to skull base petrous bone anatomy and surgery through his pioneering work on the complete apicectomy for the treatment of suppurative petrous apicitis.

  9. Untersuchungen ueber den Bau von Orbitolina (Patellina auct.) von Borneo

    NARCIS (Netherlands)

    Martin, K.

    1884-01-01

    Vor einer Reihe von Jahren (1856—57) entdeckte Everwijn am Seberoeang, linken Nebenflusse des Kapoeas, in der West-Abtheilung von Borneo, Schichten mit Versteinerungen, welche von ihm für Nummuliten gehalten wurden. Der Fundort befand sich am rechten Ufer, 4—5 Kilometer von der Mündung des

  10. The choice of time in quantum cosmology: two different approaches to Kantowski-Sachs quantum universe

    CERN Document Server

    Alvarenga, F G; Freitas, R C; Gonçalves, S V B

    2015-01-01

    In this paper we study the quantum Kantowski-Sachs model and we solve the Wheeler-DeWitt equation in minisuperspace to obtain the wave function of the corresponding universe. The perfect fluid is described by the Schutz's canonical formalism, which allows to attribute dynamical degrees of freedom to matter. The time is introduced phenomenologically using the fluid's degrees of freedom. In particular, we adopt a stiff matter fluid. The Kantowski-Sachs model is also presented with the introduction of so-called geometric time. Finally, the agreement between the results is analyzed and the possibility of equivalence between the two approaches is discussed.

  11. Korrelation der Explosionsheftigkeit mit der spezifischen Oberfläche und dem Brennwert von Stäuben

    OpenAIRE

    Gerhold, Malte

    2017-01-01

    In vielen Industrie- und Gewerbebereichen kommt es immer wieder zu Staubexplosionen, die regelmäßig zu erheblichen Sach- und Personenschäden führen. Zur Charakterisierung des Ex-plosionsverhaltens von Stäuben dienen verschiedene, experimentell ermittelte Kenngrößen. Diese beschreiben zum einen das Zündverhalten, zum anderen die Explosionsheftigkeit eines Staub/Luft-Gemischs. Gegenstand dieser Arbeit sind die Kenngrößen maximaler Explosions-überdruck und maximale Druckanstiegsgeschwindigkeit, ...

  12. Planck 2015 results. XXI. The integrated Sachs-Wolfe effect

    Science.gov (United States)

    Planck Collaboration; Ade, P. A. R.; Aghanim, N.; Arnaud, M.; Ashdown, M.; Aumont, J.; Baccigalupi, C.; Banday, A. J.; Barreiro, R. B.; Bartolo, N.; Basak, S.; Battaner, E.; Benabed, K.; Benoît, A.; Benoit-Lévy, A.; Bernard, J.-P.; Bersanelli, M.; Bielewicz, P.; Bock, J. J.; Bonaldi, A.; Bonavera, L.; Bond, J. R.; Borrill, J.; Bouchet, F. R.; Bucher, M.; Burigana, C.; Butler, R. C.; Calabrese, E.; Cardoso, J.-F.; Casaponsa, B.; Catalano, A.; Challinor, A.; Chamballu, A.; Chiang, H. C.; Christensen, P. R.; Church, S.; Clements, D. L.; Colombi, S.; Colombo, L. P. L.; Combet, C.; Couchot, F.; Coulais, A.; Crill, B. P.; Curto, A.; Cuttaia, F.; Danese, L.; Davies, R. D.; Davis, R. J.; de Bernardis, P.; de Rosa, A.; de Zotti, G.; Delabrouille, J.; Désert, F.-X.; Diego, J. M.; Dole, H.; Donzelli, S.; Doré, O.; Douspis, M.; Ducout, A.; Dupac, X.; Efstathiou, G.; Elsner, F.; Enßlin, T. A.; Eriksen, H. K.; Fergusson, J.; Fernandez-Cobos, R.; Finelli, F.; Forni, O.; Frailis, M.; Fraisse, A. A.; Franceschi, E.; Frejsel, A.; Galeotta, S.; Galli, S.; Ganga, K.; Génova-Santos, R. T.; Giard, M.; Giraud-Héraud, Y.; Gjerløw, E.; González-Nuevo, J.; Górski, K. M.; Gratton, S.; Gregorio, A.; Gruppuso, A.; Gudmundsson, J. E.; Hansen, F. K.; Hanson, D.; Harrison, D. L.; Henrot-Versillé, S.; Hernández-Monteagudo, C.; Herranz, D.; Hildebrandt, S. R.; Hivon, E.; Hobson, M.; Holmes, W. A.; Hornstrup, A.; Hovest, W.; Huffenberger, K. M.; Hurier, G.; Ilić, S.; Jaffe, A. H.; Jaffe, T. R.; Jones, W. C.; Juvela, M.; Keihänen, E.; Keskitalo, R.; Kisner, T. S.; Kneissl, R.; Knoche, J.; Kunz, M.; Kurki-Suonio, H.; Lagache, G.; Lähteenmäki, A.; Lamarre, J.-M.; Langer, M.; Lasenby, A.; Lattanzi, M.; Lawrence, C. R.; Leonardi, R.; Lesgourgues, J.; Levrier, F.; Liguori, M.; Lilje, P. B.; Linden-Vørnle, M.; López-Caniego, M.; Lubin, P. M.; Ma, Y.-Z.; Macías-Pérez, J. F.; Maggio, G.; Maino, D.; Mandolesi, N.; Mangilli, A.; Marcos-Caballero, A.; Maris, M.; Martin, P. G.; Martínez-González, E.; Masi, S.; Matarrese, S.; McGehee, P.; Meinhold, P. R.; Melchiorri, A.; Mendes, L.; Mennella, A.; Migliaccio, M.; Mitra, S.; Miville-Deschênes, M.-A.; Moneti, A.; Montier, L.; Morgante, G.; Mortlock, D.; Moss, A.; Munshi, D.; Murphy, J. A.; Naselsky, P.; Nati, F.; Natoli, P.; Netterfield, C. B.; Nørgaard-Nielsen, H. U.; Noviello, F.; Novikov, D.; Novikov, I.; Oxborrow, C. A.; Paci, F.; Pagano, L.; Pajot, F.; Paoletti, D.; Pasian, F.; Patanchon, G.; Perdereau, O.; Perotto, L.; Perrotta, F.; Pettorino, V.; Piacentini, F.; Piat, M.; Pierpaoli, E.; Pietrobon, D.; Plaszczynski, S.; Pointecouteau, E.; Polenta, G.; Popa, L.; Pratt, G. W.; Prézeau, G.; Prunet, S.; Puget, J.-L.; Rachen, J. P.; Reach, W. T.; Rebolo, R.; Reinecke, M.; Remazeilles, M.; Renault, C.; Renzi, A.; Ristorcelli, I.; Rocha, G.; Rosset, C.; Rossetti, M.; Roudier, G.; Rubiño-Martín, J. A.; Rusholme, B.; Sandri, M.; Santos, D.; Savelainen, M.; Savini, G.; Schaefer, B. M.; Scott, D.; Seiffert, M. D.; Shellard, E. P. S.; Spencer, L. D.; Stolyarov, V.; Stompor, R.; Sudiwala, R.; Sunyaev, R.; Sutton, D.; Suur-Uski, A.-S.; Sygnet, J.-F.; Tauber, J. A.; Terenzi, L.; Toffolatti, L.; Tomasi, M.; Tristram, M.; Tucci, M.; Tuovinen, J.; Valenziano, L.; Valiviita, J.; Van Tent, F.; Vielva, P.; Villa, F.; Wade, L. A.; Wandelt, B. D.; Wehus, I. K.; Yvon, D.; Zacchei, A.; Zonca, A.

    2016-09-01

    This paper presents a study of the integrated Sachs-Wolfe (ISW) effect from the Planck 2015 temperature and polarization data release. This secondary cosmic microwave background (CMB) anisotropy caused by the large-scale time-evolving gravitational potential is probed from different perspectives. The CMB is cross-correlated with different large-scale structure (LSS) tracers: radio sources from the NVSS catalogue; galaxies from the optical SDSS and the infrared WISE surveys; and the Planck 2015 convergence lensing map. The joint cross-correlation of the CMB with the tracers yields a detection at 4σ where most of the signal-to-noise is due to the Planck lensing and the NVSS radio catalogue. In fact, the ISW effect is detected from the Planck data only at ≈3σ (through the ISW-lensing bispectrum), which is similar to the detection level achieved by combining the cross-correlation signal coming from all the galaxy catalogues mentioned above. We study the ability of the ISW effect to place constraints on the dark-energy parameters; in particular, we show that ΩΛ is detected at more than 3σ. This cross-correlation analysis is performed only with the Planck temperature data, since the polarization scales available in the 2015 release do not permit significant improvement of the CMB-LSS cross-correlation detectability. Nevertheless, the Planck polarization data are used to study the anomalously large ISW signal previously reported through the aperture photometry on stacked CMB features at the locations of known superclusters and supervoids, which is in conflict with ΛCDM expectations. We find that the current Planck polarization data do not exclude that this signal could be caused by the ISW effect. In addition, the stacking of the Planck lensing map on the locations of superstructures exhibits a positive cross-correlation with these large-scale structures. Finally, we have improved our previous reconstruction of the ISW temperature fluctuations by combining the

  13. Energy in the Kantowski–Sachs space-time using teleparallel geometry

    Indian Academy of Sciences (India)

    Anuradha Das Purkayastha

    2013-04-01

    The purpose of this paper is to examine the energy content of the inflationary Universe described by Kantowski–Sachs space-time in quasilocal approach of teleparallel gravity and in the Hamiltonian structure of the teleparallel equivalent of general relativity. The teleparallel versions of field equations are also derived in such a space-time.

  14. Iconicity as the key to the poetry of Nelly Sachs (1891-1970

    Directory of Open Access Journals (Sweden)

    H. Ester

    2011-06-01

    Full Text Available In her poetry Nelly Sachs tried to overcome all obstaclesi in order to speak about the unspeakable. Words that could adequately embody the horrors of the Nazi concentration camps were lacking. Nevertheless, it was necessary to speak about the experience for the sake of both herself and other victims of the camps. Through her poetry Sachs tests the validity and strength of both traditional images and biblical stories about suffering and grace. Words and images enable her to touch the experiences of people. However, she questions the generally accepted meaning of words in German. Her use of language strives to be different and to draw the attention to both the difficulties and risks of writing authentic words with the necessary symbolic strength. Sachs’ mental fragility made her very vulnerable and caused her to walk on the edge of total silence. As a consequence of her vulnerability, she tried with her whole heart to gain Paul Celan’s sympathy for her way of writing and efforts to turn the events in the concentration camps into dignified and true poetry. The relationship between Celan and Sachs reveals that the true meaning of poetry in her life was a manner of survival. The differences between the two poets provide insight into the specific poetic laws at work in the poetry of Nelly Sachs.

  15. Outcomes of arthroscopic "Remplissage": capsulotenodesis of the engaging large Hill-Sachs lesion

    Directory of Open Access Journals (Sweden)

    Mayo Lee

    2011-06-01

    Full Text Available Abstract Background A Hill-Sachs lesion of the humeral head after a shoulder dislocation is clinically insignificant in most cases. However, a sizable defect will engage with the anterior rim of the glenoid and cause instability even after anterior glenoid reconstruction. The purpose of this study was to evaluate the outcome of arthroscopic capsulotenodesis of the posterior capsule and infraspinatus tendon ("remplissage" to seal a large engaging Hill-Sachs lesion in an unstable shoulder. Methods This was a prospective follow-up study of patients who underwent arthroscopic surgery for recurrent shoulder instability with a large engaging Hill-Sachs lesion from 2007 to 2009. The clinical results were measured preoperatively and postoperatively with the Simple Shoulder test (SST and the Rowe score for instability. Results Eleven patients met the inclusion criteria of this study. The mean follow-up time was 30 months (range 24 to 35 months. At the last follow-up, significant improvement was observed in both scores with no recurrent dislocations. The mean SST improved from 6.6 to 11 (p Conclusions Arthroscopic remplissage for shoulder instability is an effective soft tissue technique to seal a large engaging Hill-Sachs lesion with respect to recurrence rate, range of motion and shoulder function.

  16. 78 FR 24447 - Goldman Sachs Trust, et al.; Notice of Application

    Science.gov (United States)

    2013-04-25

    ... Sachs, an investment adviser registered under the Advisers Act and a broker-dealer registered under the..., to the extent consistent with its investment objectives, policies, strategies and limitations, in..., or broker or dealer if registered under the Securities Exchange Act of 1934 (``Exchange Act''),...

  17. Ellis Von Creveld Syndrome

    Directory of Open Access Journals (Sweden)

    Afshar H

    1999-01-01

    Full Text Available One patient with Ellis Von Creveld syndrome contains: dwarfism, congenital heart"ndisease, ectodermal dysplasia, polyductyly, an abnormally wide labial frenum and maxillary"nmolars with single root.

  18. Eifersucht und Frauenlist: Boccaccios Decameron und seine Rezeption in der frühen Neuzeit am Beispiel von Hans Sachsens Fastnachtspiel Der gross Eyferer, der sein Weib Beicht höret

    Directory of Open Access Journals (Sweden)

    Marija Javor Briški

    2014-12-01

    Full Text Available Auf der Grundlage des sog. Zainer- (um 1476 und des Cammerlander-Druckes (1535 wird die produktive Rezeption der fünften Novelle des siebten Tages von Boccaccios Decameron in Hans Sachsens Fastnachtspiel Der gross Eiferer, der sein Weib Beicht höret untersucht. Im Fokus des kontrastiven Vergleichs zwischen der Novelle und dem Fastnachtspiel stehen der Affekt der Eifersucht und das Motiv der List. Die Gründe für die Transformationen im Dramentext von Hans Sachs sind u. a. die Dekontextualisierung der Novelle und ihre Instrumentalisierung als pragmatische Unterweisung der frühbürgerlichen protestantischen Gesellschaft im Bereich der ehelichen Ordnung.

  19. Lars von Triers film

    DEFF Research Database (Denmark)

    Nielsen, Lisbeth Overgaard

    2007-01-01

    Afhandlingen undersøger Lars von Triers filmæstetik, som den kommer til udtryk i spillefilmene fra perioden 1984-2007. Afhandlingen analyserer de enkelte films stil, virkningsstrategi og betydningsdannelse.......Afhandlingen undersøger Lars von Triers filmæstetik, som den kommer til udtryk i spillefilmene fra perioden 1984-2007. Afhandlingen analyserer de enkelte films stil, virkningsstrategi og betydningsdannelse....

  20. Sachês antimicrobianos em pós-colheita de manga

    Directory of Open Access Journals (Sweden)

    Eber Antonio Alves Medeiros

    2011-10-01

    Full Text Available Objetivou-se com este trabalho desenvolver sachês incorporados com óleos essenciais avaliando as propriedades físico-químicas e microbiológicas de mangas armazenadas em saco de papel contendo estes sachês em seu interior. Os óleos essenciais de orégano (Origanum vulgaris e capim-limão (Cymbopogon citratus foram incorporados em saches, e sua atividade antimicrobiana foi testada nos fungos Colletotrichum gloeosporides, Lasiodiplodia theobromae, Xanthomonas campestris pv. mangiferae indica, Alternaria alternata. Frutos de manga 'Tommy Atkins' foram acondicionados individualmente em sacos de papel contendo em seu interior um sachê antimicrobiano e mantidos a 25 °C ± 2 °C e UR 80% ± 5% por nove dias. Os parâmetros cor da epiderme, firmeza de polpa, sólidos solúveis, acidez titulável e pH sofreram pouca influência dos óleos essenciais de orégano e capim limão, indicando que a presença do óleo essencial não altera as características físico-químicas da polpa de manga. Os sachês ativos incorporados com óleos essenciais de orégano e capim limão apresentaram controle no crescimento dos microrganismos testados, sendo o capim-limão mais eficiente, reduzindo em aproximadamente 2 ciclos Log a contagem de mesófilos aeróbios e fungos filamentosos e leveduras em relação ao tratamento controle empregado.

  1. Does the Arthroscopic Latarjet Procedure Effectively Correct "Off-Track" Hill-Sachs Lesions?

    Science.gov (United States)

    Plath, Johannes E; Henderson, Daniel J H; Coquay, Julien; Dück, Klaus; Haeni, David; Lafosse, Laurent

    2017-09-01

    The glenoid track concept describes the dynamic interaction of bipolar bone loss in anterior glenohumeral instability. Initial studies have successfully demonstrated this concept's application in clinical populations. In clinical practice, the Latarjet procedure is commonly the preferred treatment in addressing "off-track" Hill-Sachs lesions. The effectiveness of this procedure in restoring such lesions to an "on-track" state, however, has not yet been evaluated or described in the literature. The Latarjet procedure would transform "off-track" Hill-Sachs lesions to "on-track" lesions. Lesions would remain "on-track" during follow-up, despite glenoid remodeling. Case series; Level of evidence, 4. Patients with "off-track" Hill-Sachs lesions treated with the arthroscopic Latarjet procedure between March 2013 and May 2014 were included. Glenoid track and coracoid graft contact surface area measurements using 3-dimensional computed tomography (3D-CT) were performed preoperatively and at 6-week, 6-month, and at least 12-month (final) follow-up. The mean final follow-up was 23 months. The glenoid diameter, as a percentage of the native glenoid, was also calculated from this imaging. Twenty-six patients met the inclusion criteria. 3D-CT scans were available for all patients preoperatively and postoperatively, with 21 patients (81%) undergoing 6-month follow-up CT and 19 patients (73%) undergoing final follow-up CT. Hill-Sachs lesions remained "on-track" at all follow-up time points. The mean glenoid diameter changed significantly from 84.6% preoperatively to 122.8% at 6 weeks ( P Latarjet procedure provides an effective treatment for "off-track" engaging Hill-Sachs lesions, despite an evident glenoid remodeling process. At a mean of 23 months postoperatively, a mean persisting enlargement of the glenoid arc of 14% beyond native dimensions remained, avoiding a recurrent "off-track" lesion in 32% of patients, which would otherwise have occurred with complete remodeling.

  2. Word, Body, Power: A Reading of Shakespeare’s Julius Caesar and Ariel Dorfman’s Death and the Maiden

    Directory of Open Access Journals (Sweden)

    Diego Saglia

    2014-05-01

    Full Text Available Il saggio prende in esame il corpo come luogo di operazioni di scrittura tese a mettere in scena effetti di potere “in atto”. Attraverso esplorazioni testuali di opere significative, sebbene lontane nel tempo e appartenenti a sistemi linguistico-culturali distanti, come il Julius Caesar di Shakespeare e La muerte y la doncella (Death and the Maiden di Ariel Dorfman, si intendono segnalare aspetti formali, modalità semiotiche, configurazioni ideologiche e strutture affettive proprie di una prassi retorica in cui la rappresentazione del corpo, tramite il linguaggio inteso come proiezione della fisicità, corrisponde a un’ostensione del potere come nesso di gesto e voce, azione e discorso – e soprattutto come zona di conflitto. Nelle due opere in questione la parola diventa visibile come meccanismo di esplicitazione di una fisicità che è zona di scontro e confronto tra effetti di potere quali la coercizione e la resistenza, tra occultamento e svelamento della verità, tra identità maschile e femminile. Alla luce di queste prove testuali, la scrittura del corpo si profila come una performance, densa di “intensità affettive”, dello stesso corpo in quanto punto di incrocio di effetti di parola e nucleo di atti ideologici e politici – un corpo, insomma, che è sia soggetto della storia, sia oggetto di molteplici operazioni e negoziazioni retoriche.

  3. The frequency of Tay-Sachs disease causing mutations in the Brazilian Jewish population justifies a carrier screening program

    Directory of Open Access Journals (Sweden)

    Roberto Rozenberg

    Full Text Available CONTEXT: Tay-Sachs disease is an autosomal recessive disease characterized by progressive neurologic degeneration, fatal in early childhood. In the Ashkenazi Jewish population the disease incidence is about 1 in every 3,500 newborns and the carrier frequency is 1 in every 29 individuals. Carrier screening programs for Tay-Sachs disease have reduced disease incidence by 90% in high-risk populations in several countries. The Brazilian Jewish population is estimated at 90,000 individuals. Currently, there is no screening program for Tay-Sachs disease in this population. OBJECTIVE: To evaluate the importance of a Tay-Sachs disease carrier screening program in the Brazilian Jewish population by determining the frequency of heterozygotes and the acceptance of the program by the community. SETTING: Laboratory of Molecular Genetics - Institute of Biosciences - Universidade de São Paulo. PARTICIPANTS: 581 senior students from selected Jewish high schools. PROCEDURE: Molecular analysis of Tay-Sachs disease causing mutations by PCR amplification of genomic DNA, followed by restriction enzyme digestion. RESULTS: Among 581 students that attended educational classes, 404 (70% elected to be tested for Tay-Sachs disease mutations. Of these, approximately 65% were of Ashkenazi Jewish origin. Eight carriers were detected corresponding to a carrier frequency of 1 in every 33 individuals in the Ashkenazi Jewish fraction of the sample. CONCLUSION: The frequency of Tay-Sachs disease carriers among the Ashkenazi Jewish population of Brazil is similar to that of other countries where carrier screening programs have led to a significant decrease in disease incidence. Therefore, it is justifiable to implement a Tay-Sachs disease carrier screening program for the Brazilian Jewish population.

  4. Assessment of coincidence and defect sizes in Bankart and Hill-Sachs lesions after anterior shoulder dislocation: a radiological study.

    Science.gov (United States)

    Horst, K; Von Harten, R; Weber, C; Andruszkow, H; Pfeifer, R; Dienstknecht, T; Pape, H C

    2014-02-01

    Bankart and Hill-Sachs lesions are often associated with anterior shoulder dislocation. The MRI technique is sensitive in diagnosing both injuries. The aim of this study was to investigate Bankart and Hill-Sachs lesions with MRI to determine the correlation in occurrence and defect sizes of these lesions. Between 2006 and 2013, 446 patients were diagnosed with an anterior shoulder dislocation and 105 of these patients were eligible for inclusion in the study. All patients were examined using MRI. Bankart lesions were classified as cartilaginous or bony lesions. Hill-Sachs lesions were graded I-III using a modified Calandra classification. The co-occurrence of injuries was high [odds ratio (OR) = 11.47; 95% confidence interval (CI) = 3.60-36.52; p Bankart lesion and the grade of a Hill-Sachs lesion was found (ρ = 0.34; 95% CI = 0.16-0.49; p Bankart lesions co-occurred more often with large Hill-Sachs lesions (O  = 1.24; 95% CI = 1.02-1.52; p = 0.033). If either lesion is diagnosed, the patient is 11 times more likely to have suffered the associated injury. The size of a Hill-Sachs lesion determines the co-occurrence of cartilaginous or bony Bankart lesions. Age plays a role in determining the type of Bankart lesion as well as the co-occurrence of Bankart and Hill-Sachs lesions. This study is the first to demonstrate the use of high-quality MRI in a reasonably large sample of patients, a positive correlation of Bankart and Hill-Sachs lesions in anterior shoulder dislocations and an association between the defect sizes.

  5. Assessment of coincidence and defect sizes in Bankart and Hill–Sachs lesions after anterior shoulder dislocation: a radiological study

    Science.gov (United States)

    Von Harten, R; Weber, C; Andruszkow, H; Pfeifer, R; Dienstknecht, T; Pape, H C

    2014-01-01

    Objective: Bankart and Hill–Sachs lesions are often associated with anterior shoulder dislocation. The MRI technique is sensitive in diagnosing both injuries. The aim of this study was to investigate Bankart and Hill–Sachs lesions with MRI to determine the correlation in occurrence and defect sizes of these lesions. Methods: Between 2006 and 2013, 446 patients were diagnosed with an anterior shoulder dislocation and 105 of these patients were eligible for inclusion in the study. All patients were examined using MRI. Bankart lesions were classified as cartilaginous or bony lesions. Hill–Sachs lesions were graded I–III using a modified Calandra classification. Results: The co-occurrence of injuries was high [odds ratio (OR) = 11.47; 95% confidence interval (CI) = 3.60–36.52; p Bankart lesion and the grade of a Hill–Sachs lesion was found (ρ = 0.34; 95% CI = 0.16–0.49; p Bankart lesions co-occurred more often with large Hill–Sachs lesions (OR = 1.24; 95% CI = 1.02–1.52; p = 0.033). Conclusion: If either lesion is diagnosed, the patient is 11 times more likely to have suffered the associated injury. The size of a Hill–Sachs lesion determines the co-occurrence of cartilaginous or bony Bankart lesions. Age plays a role in determining the type of Bankart lesion as well as the co-occurrence of Bankart and Hill–Sachs lesions. Advances in knowledge: This study is the first to demonstrate the use of high-quality MRI in a reasonably large sample of patients, a positive correlation of Bankart and Hill–Sachs lesions in anterior shoulder dislocations and an association between the defect sizes. PMID:24452107

  6. Preconception risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease.

    Science.gov (United States)

    Hussein, Norita; Weng, Stephen F; Kai, Joe; Kleijnen, Jos; Qureshi, Nadeem

    2015-08-12

    Globally, about five per cent of children are born with congenital or genetic disorders. The most common autosomal recessive conditions are thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease, with higher carrier rates in specific patient populations. Identifying and counselling couples at genetic risk of the conditions before pregnancy enables them to make fully informed reproductive decisions, with some of these choices not being available if genetic counselling is only offered in an antenatal setting. To assess the effectiveness of systematic preconception genetic risk assessment to improve reproductive outcomes in women and their partners who are identified as carriers of thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease in healthcare settings when compared to usual care. We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group's Trials Registers. In addition, we searched for all relevant trials from 1970 (or the date at which the database was first available if after 1970) to date using electronic databases (MEDLINE, Embase, CINAHL, PsycINFO), clinical trial databases (National Institutes of Health, Clinical Trials Search portal of the World Health Organization, metaRegister of controlled clinical trials), and hand searching of key journals and conference abstract books from 1998 to date (European Journal of Human Genetics, Genetics in Medicine, Journal of Community Genetics). We also searched the reference lists of relevant articles, reviews and guidelines and also contacted subject experts in the field to request any unpublished or other published trials.Date of latest search of the registers: 25 June 2015.Date of latest search of all other sources: 10 December 2014. Any randomised or quasi-randomised control trials (published or unpublished) comparing reproductive outcomes of systematic preconception genetic risk assessment for thalassaemia, sickle cell disease, cystic fibrosis and Tay-Sachs disease

  7. [Quo vadis cardiologia? Or: An nescis, mi fili, quantilla prudentia mundus regatur? (Pope Julius III)].

    Science.gov (United States)

    Kübler, W

    2003-02-01

    In order to recognize and to solve problems, a look in the future is essential despite many uncertainties. Besides sound bed side-teaching, the main aim in the education of the students should be to acquire self-responsiveness and an attitude of permanent learning. It is more than doubtful whether the high expectations of health politicians will be met to limit the cost of in-patient treatment by introducing diagnosis-related groups in combination with evidence-based medicine, as this method has several severe limitations in order to fulfill this duty. The new financial system based on diagnosis-related groups will be in favor of private investors compared to the government-dependent university hospitals. The changing population pyramid implies not only higher costs but in addition severe medical problems. Within the changing society, alterations in the patient's behavior are to be expected. Several factors will contribute to make the doctor's profession less attractive. In the developing countries a rapid increase in the non-communicative diseases, i.e., in coronary heart disease, has to be expected. Apart from the prolongation of life - especially during its terminal phase - it is mainly the allocation of resources between industrialized and developing countries which will determine the ethical discussion. Germany has lost its leading position of the 19th and beginning of the 20th century in medical sciences. This was based on the liberal university system introduced by Wilhelm von Humboldt. Several pioneering innovations of German cardiologists during the 20th century have not strengthened German industry - in contrast to the situation in the 19th century. The general conditions in Germany, which are not research oriented, have prompted the majority of the pharmaceutical firms to transfer their research activities into foreign countries. In addition Germany's cardiological research has lost basic sciences partners for clinically orientated basic research, as

  8. Energetisches Verhalten von Doppelfassaden

    OpenAIRE

    2002-01-01

    Durch die Forderung nach einer natürlichen Lüftung von Bürogebäuden und einem effektiven Sonnenschutz in Hochhäusern haben Doppelfassaden einen hohen Stellenwert erreicht. Das energetische Verhalten von Doppelfassaden ist Gegenstand zahlreicher Veröffentlichungen. Bisher liegen jedoch nur wenige Messungen in ausgeführten Gebäuden vor.Im Rahmen dieser Arbeit wurden drei Gebäude mit Doppelfassaden detailliert vermessen. Die Langzeitmessungen erfassten über mindestens ein Jahr unter anderem die ...

  9. Kontextualisierung von Queer Theory

    Directory of Open Access Journals (Sweden)

    Anna Voigt

    2008-03-01

    Full Text Available Christine M. Klapeer legt in diesem Einführungsband dar, aus welchen politischen und theoretischen Kontexten heraus sich ‚queer‘ zu einem Begriff mit besonderem politischem und theoretischem Gehalt entwickelt hat. Wesentlich zielt sie dabei auf eine kritische Kontextualisierung von „queer theory”. Die Autorin geht zunächst auf das Gay Liberation Movement ein, grenzt die Queer Theory vom Poststrukturalismus, von feministischen Theorien und den Lesbian and Gay Studies ab, beleuchtet Eckpunkte queeren Denkens und zeichnet schließlich die Entwicklungen in Österreich sowohl politisch-rechtlich als auch bewegungsgeschichtlich und in der Wissenschaftslandschaft nach.

  10. Noncanonical phase-space noncommutativity and the Kantowski-Sachs singularity for black holes

    Science.gov (United States)

    Bastos, Catarina; Bertolami, Orfeu; Dias, Nuno Costa; Prata, João Nuno

    2011-07-01

    We consider a cosmological model based upon a noncanonical noncommutative extension of the Heisenberg-Weyl algebra to address the thermodynamical stability and the singularity problem of black holes whose interior are described by the Kantowski-Sachs metric and modeled by a noncommutative extension of the Wheeler-DeWitt equation. We compute the temperature and entropy of these black holes and compare the results with the Hawking values. We observe that it is actually the noncommutativity in the momentum sector that allows for the existence of a minimum in the potential, which is the key to apply the Feynman-Hibbs procedure. It is shown that this noncommutative model generates a nonunitary dynamics that predicts a vanishing probability in the neighborhood of the singularity. This result effectively regularizes the Kantowski-Sachs singularity and generalizes a similar result, previously obtained for the case of Schwarzschild black holes.

  11. Exact solution of the Einstein-Skyrme model in a Kantowski-Sachs spacetime

    Science.gov (United States)

    Paliathanasis, Andronikos; Tsamparlis, Michael

    2017-04-01

    We consider a Skyrme fluid with a constant radial profile in locally rotational Kantowski-Sachs spacetime. The Skyrme fluid is an anisotropic fluid with zero heat flux and with an equation of state parameter wS that |ws | ≤ 1/3. From the Einstein field equations we define the Wheeler-DeWitt equation. For the last equation we perform a Lie symmetry classification and we determine the invariant solutions for the wavefunction of the model. Moreover from the Lie symmetries of the Wheeler-DeWitt equation we construct Noetherian conservation laws for the field equations which we use in order to write the solution in closed form. We show that all of the cosmological parameters are expressed in terms of the scale factor of the two dimensional sphere of the Kantowski-Sachs spacetime. Finally from the application of Noether's theorem for the Wheeler-DeWitt equation we derive conservation laws for the wavefunction of the universe.

  12. Correlation of augmented startle reflex with brainstem electrophysiological responses in Tay-Sachs disease.

    Science.gov (United States)

    Nakamura, Sadao; Saito, Yoshiaki; Ishiyama, Akihiko; Sugai, Kenji; Iso, Takashi; Inagaki, Masumi; Sasaki, Masayuki

    2015-01-01

    To clarify the evolution of an augmented startle reflex in Tay-Sachs disease and compare the temporal relationship between this reflex and brainstem evoked potentials. Clinical and electrophysiological data from 3 patients with Tay-Sachs disease were retrospectively collected. The augmented startle reflex appeared between the age of 3 and 17 months and disappeared between the age of 4 and 6 years. Analysis of brainstem auditory evoked potentials revealed that poor segregation of peak I, but not peak III, coincided with the disappearance of the augmented startle reflex. A blink reflex with markedly high amplitude was observed in a patient with an augmented startle reflex. The correlation between the augmented startle reflex and the preservation of peak I but not peak III supports the theory that the superior olivary nucleus is dispensable for this reflex. The blink reflex with high amplitudes may represent augmented excitability of reticular formation at the pontine tegmentum in Tay-Sachs disease, where the pattern generators for the augmented startle and blink reflexes may functionally overlap. Copyright © 2014 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.

  13. Lyso-GM2 ganglioside: a possible biomarker of Tay-Sachs disease and Sandhoff disease.

    Directory of Open Access Journals (Sweden)

    Takashi Kodama

    Full Text Available To find a new biomarker of Tay-Sachs disease and Sandhoff disease. The lyso-GM2 ganglioside (lyso-GM2 levels in the brain and plasma in Sandhoff mice were measured by means of high performance liquid chromatography and the effect of a modified hexosaminidase (Hex B exhibiting Hex A-like activity was examined. Then, the lyso-GM2 concentrations in human plasma samples were determined. The lyso-GM2 levels in the brain and plasma in Sandhoff mice were apparently increased compared with those in wild-type mice, and they decreased on intracerebroventricular administration of the modified Hex B. The lyso-GM2 levels in plasma of patients with Tay-Sachs disease and Sandhoff disease were increased, and the increase in lyso-GM2 was associated with a decrease in Hex A activity. Lyso-GM2 is expected to be a potential biomarker of Tay-Sachs disease and Sandhoff disease.

  14. Energetische Verwertung von Biomasse

    Science.gov (United States)

    Zahoransky, Richard; Allelein, Hans-Josef; Bollin, Elmar; Oehler, Helmut; Schelling, Udo

    Etwa 0,1% der Solarenergie wandeln sich durch Photosynthese aus dem Kohlendioxid der Luft in Biomasse um. Die Biomassen sind als Festbrennstoff nutzbar oder zu gasförmigen Brennstoffen weiterverarbeitbar. Zwei Arten von Biomassen sind zu unterscheiden: Anfallende Biomasse

  15. Rhizostomeen von Manila

    NARCIS (Netherlands)

    Stiasny, G.

    1924-01-01

    Die hier beschriebene kleine Scyphomedusen-Sammlung wurde von Herrn Director P. B. Sivickis, Dept. of Zoology, University of Philippines, Manila, dem Rijksmuseum van Natuurlijke Historie in Leiden überwiesen. Das Material wurde im December 1922 in Manila-bay gefischt und befindet sich in bestem Erha

  16. Challenges to the implementation of International Health Regulations (2005) on Preventing Infectious Diseases: experience from Julius Nyerere International Airport, Tanzania

    Science.gov (United States)

    Bakari, Edith; Frumence, Gasto

    2013-01-01

    Background The International Health Regulations (IHR) (2005) is a legal instrument binding all World Health Organization (WHO) member States. It aims to prevent and control public health emergencies of international concern. Country points of entry (POEs) have been identified as potential areas for effective interventions to prevent the transmission of infectious diseases across borders. The agreement postulates that member states will strengthen core capacities detailed in the IHR (2005), including those specified for the POE. This study intended to assess the challenges faced in implementing the IHR (2005) requirements at Julius Nyerere International Airport (JNIA), Dar es Salaam. Design A cross-sectional, descriptive study, employing qualitative methods, was conducted at the Ministry of Health and Social Welfare (MoHSW), WHO, and JNIA. In-depth interviews, focus group discussions (FGDs) and documentary reviews were used to obtain relevant information. Respondents were purposively enrolled into the study. Thematic analysis was used to generate study findings. Results Several challenges that hamper implementation of the IHR (2005) were identified: (1) none of the 42 Tanzanian POEs have been specifically designated to implement IHR (2005). (2) Implementation of the IHR (2005) at the POE was complicated as it falls under various uncoordinated government departments. Although there were clear communication channels at JNIA that enhanced reliable risk communication, the airport lacked isolated rooms specific for emergence preparedness and response to public health events. Conclusions JNIA is yet to develop adequate core capacities required for implementation of the IHR (2005). There is a need for policy managers to designate JNIA to implement IHR (2005) and ensure that public health policies, legislations, guidelines, and practice at POE are harmonized to improve international travel and trade. Policy makers and implementers should also ensure that implementation of

  17. La fotografía de Julius Shulman y la construcción de la imagen de la arquitectura del sur de California

    OpenAIRE

    Daniel Díez Martínez

    2014-01-01

    A Julius Shulman le correspondió, casi en exclusiva, la labor de cronista gráfico de la arquitectura moderna en el sur de California. Consciente de la dificultad de hacer ver al público la belleza de estas construcciones, Shulman desarrolló un lenguaje propio con un marcado sentido escenográfico, un encuentro entre la fotografía arquitectónica clásica y la publicidad contemporánea inspirada en la cultura pop en la que la colocación de los muebles en intervalos estratégicos, la iluminación, la...

  18. Abschied von Ingeborg Pomp

    OpenAIRE

    Hänsel, Rosemarie

    2007-01-01

    Am 4. Juni 2007 erhielten wir die traurige Nachricht, dass Ingeborg Barbara Pomp, Leiterin i. R. der Stenografischen Sammlung von 1996 bis 2006 nach kurzer schwerer Krankheit verstorben ist. Die Mitarbeiterinnen und Mitarbeiter der Sächsischen Landesbibliothek – Staats- und Universitätsbibliothek trauern um eine liebenswerte Kollegin, die sich immer mit einem Höchstmaß an persönlichem Einsatz für die Weiterentwicklung der Stenografischen Sammlung engagiert hat.

  19. Nutzerorientiertes Management von materiellen und immateriellen Informationsobjekten

    OpenAIRE

    Hübsch, Chris

    2001-01-01

    Schaffung einer stabilen, erweiterbaren und skalierbaren Infrastruktur für die Bereitstellung von Diensten im Umfeld von Bibliotheken und ähnlichen wissensanbietenden Einrichtungen unter Verwendung von XML-RPC und Python.

  20. Nutzerorientiertes Management von materiellen und immateriellen Informationsobjekten

    OpenAIRE

    Hübsch, Chris

    2001-01-01

    Schaffung einer stabilen, erweiterbaren und skalierbaren Infrastruktur für die Bereitstellung von Diensten im Umfeld von Bibliotheken und ähnlichen wissensanbietenden Einrichtungen unter Verwendung von XML-RPC und Python.

  1. Expanding the spectrum of HEXA mutations in Indian patients with Tay–Sachs disease

    Directory of Open Access Journals (Sweden)

    Jayesh Sheth

    2014-01-01

    Full Text Available Tay–Sachs disease is an autosomal recessive neurodegenerative disorder occurring due to impaired activity of β-hexosaminidase-A (EC 3.2.1.52, resulting from the mutation in HEXA gene. Very little is known about the molecular pathology of TSD in Indian children except for a few mutations identified by us. The present study is aimed to determine additional mutations leading to Tay–Sachs disease in nine patients confirmed by the deficiency of β-hexosaminidase-A (C (D175A and c.805G>C (p.G269R in one case; and one small 1 bp deletion c.426delT (p.F142LfsX57 and one splice site mutation c.459+4A>C in the other two cases respectively. None of these mutations were detected in 100 chromosomes from healthy individuals of the same ethnic group. Three previously reported missense mutations, (i c.532C>T (p.R178C, (ii c.964G>T (p.D322Y, and (iii c.1385A>T (p.E462V; two nonsense mutations (i c.709C>T (p.Q237X and (ii c.1528C>T (p.R510X, one 4 bp insertion c.1277_1278insTATC (p.Y427IfsX5 and one splice site mutation c.459+5G>A were also identified in six cases. We observe from this study that novel mutations are more frequently observed in Indian patients with Tay–Sachs disease with clustering of ~73% of disease causing mutations in exons 5 to 12. This database can be used for a carrier rate screening in the larger population of the country.

  2. Expanding the spectrum of HEXA mutations in Indian patients with Tay-Sachs disease.

    Science.gov (United States)

    Sheth, Jayesh; Mistri, Mehul; Datar, Chaitanya; Kalane, Umesh; Patil, Shekhar; Kamate, Mahesh; Shah, Harshuti; Nampoothiri, Sheela; Gupta, Sarita; Sheth, Frenny

    2014-01-01

    Tay-Sachs disease is an autosomal recessive neurodegenerative disorder occurring due to impaired activity of β-hexosaminidase-A (EC 3.2.1.52), resulting from the mutation in HEXA gene. Very little is known about the molecular pathology of TSD in Indian children except for a few mutations identified by us. The present study is aimed to determine additional mutations leading to Tay-Sachs disease in nine patients confirmed by the deficiency of β-hexosaminidase-A (C (D175A) and c.805G>C (p.G269R) in one case; and one small 1 bp deletion c.426delT (p.F142LfsX57) and one splice site mutation c.459+4A>C in the other two cases respectively. None of these mutations were detected in 100 chromosomes from healthy individuals of the same ethnic group. Three previously reported missense mutations, (i) c.532C>T (p.R178C), (ii) c.964G>T (p.D322Y), and (iii) c.1385A>T (p.E462V); two nonsense mutations (i) c.709C>T (p.Q237X) and (ii) c.1528C>T (p.R510X), one 4 bp insertion c.1277_1278insTATC (p.Y427IfsX5) and one splice site mutation c.459+5G>A were also identified in six cases. We observe from this study that novel mutations are more frequently observed in Indian patients with Tay-Sachs disease with clustering of ~ 73% of disease causing mutations in exons 5 to 12. This database can be used for a carrier rate screening in the larger population of the country.

  3. Management of an engaging Hill-Sachs lesion: arthroscopic remplissage with Bankart repair versus Latarjet procedure.

    Science.gov (United States)

    Cho, Nam Su; Yoo, Jae Hyun; Rhee, Yong Girl

    2016-12-01

    This study compared the clinical outcomes of arthroscopic remplissage with Bankart repair and Latarjet operation in patients with a large engaging Hill-Sachs lesion. Thirty-seven shoulders subjected to arthroscopic remplissage with a Bankart repair (group A) and 35 shoulders subjected to a Latarjet operation (group B), for a large engaging Hill-Sachs lesion without significant glenoid bone loss, were retrospectively evaluated. Each group was followed up for a mean more than 2-year period. At the last follow-up, postoperative pain, shoulder mobility, muscle strength, Rowe score, and UCLA score revealed no significant difference between the two groups. The postoperative mean deficit in external rotation at the side (ERs) was 8° ± 23° in group A (P = 0.044). In group B, the mean deficits in ERs, external rotation at 90° of abduction, and internal rotation to the posterior were 10° ± 20°, 7° ± 16°, and 1.9° ± 4°, respectively (P = 0.004, 0.022, and 0.009, respectively). The recurrence rate was 5.4 % (two shoulders) in group A and 5.7 % (two shoulders) in group B (n.s.). The overall complication rate was significantly higher in group B (14.3 %) than in group A (0 %) (P = 0.017). For recurrent anterior shoulder instability with a large engaging Hill-Sachs lesion, both arthroscopic remplissage with Bankart repair and the Latarjet procedure were safe and reliable techniques with a low recurrence rate. However, the Latarjet group had a significantly higher postoperative complication rate than the remplissage group. Case-control study, Level III.

  4. Results of arthroscopic Bankart repair with Hill-Sachs remplissage for anterior shoulder instability.

    Science.gov (United States)

    Bonnevialle, Nicolas; Azoulay, Vadim; Faraud, Amélie; Elia, Fanny; Swider, Pascal; Mansat, Pierre

    2017-05-11

    The aim of this study was to evaluate mid-term outcomes of Bankart repair with Hill-Sachs remplissage (BHSR) and to highlight prognostic factors of failure. Thirty-four patients operated on for anterior shoulder instability with BHSR were enrolled in a prospective non-randomised study. Clinical and radiographic evaluation was performed at 1.5, three, six months and yearly thereafter. Outcome measures included Rowe and Walch-Duplay score. At mean follow-up of 35 months (24-63), the Rowe and Walch-Duplay scores reached respectively 92.7 and 88.2 points. The mean deficit in external rotation was 6° in ER1 and 1° in ER2 (p = 0.4, p = 0.9 respectively). Five patients (14.7%) had a recurrence of instability and three others had a persistent anterior apprehension. In the failure group, the Hill-Sachs lesion was deeper (26% vs 19% of the humeral diameter; p = 0.04) and range of motion at 1.5 months postoperatively was greater. Age at surgery, pre-operative instability severity index score (ISIS), hyperlaxity, type and level of sport, amount of glenoid bone loss had no correlation with failure rate. The rate of failure at mid-term follow-up of BHSR was higher than commonly reported. The premature recovery of range of motion seems to be a clinical sign of failure at follow-up. Moreover, in case of deep Hill-Sachs lesion (>20%) an alternative procedure should be considered. Level IV.

  5. Bianchi type-I, type-III and Kantowski-Sachs solutions in f( T) gravity

    Science.gov (United States)

    Rodrigues, M. E.; Kpadonou, A. V.; Rahaman, F.; Oliveira, P. J.; Houndjo, M. J. S.

    2015-06-01

    In the context of modified tele-parallel theory of gravity, we undertake cosmological anisotropic models and search for their solutions. Within a suitable choice of non-diagonal tetrads, the decoupled equations of motion are obtained for Bianchi-I, Bianchi-III and Kantowski-Sachs models, from which we obtain the correspondent solutions. By the way, energy density and pressures are also obtained, showing, as an important result, that our universe may live a quintessence like universe even while anisotropic models are considered.

  6. lnduced Pluripotent Stem cells disease modeling: approaching Gaucher and Tay Sachs

    OpenAIRE

    Lorenzo Vivas, Erica

    2013-01-01

    Las iPS (células pluripotentes inducidas) se han revelado como potentes herramientas en la creación de modelos de enfermedades humanas para su estudio y el testeo de potenciales drogas. En este marco hemos desarrollado un proyecto para derivar iPS de fibroblastos de pacientes de Gaucher y Tay Sachs, ambas enfermedades monogénicas recesivas. La enfermedad de Gaucher se caracteriza por la deficiencia de la glucocerebrosidasa (GBA), lo que conlleva la acumulación de su substrato, la glucosi...

  7. Cross-correlation between thermal Sunyaev-Zeldovich effect and the integrated Sachs-Wolfe effect

    CERN Document Server

    Creque-Sarbinowski, Cyril; Kamionkowski, Marc

    2016-01-01

    Large-angle fluctuations in the cosmic microwave background (CMB) temperature induced by the integrated Sachs-Wolfe (ISW) effect and Compton-y distortions from the thermal Sunyaev-Zeldovich (tSZ) effect are both due to line-of-sight density perturbations. Here we calculate the cross-correlation between these two signals. Measurement of this cross-correlation can be used to test the redshift distribution of the tSZ distortion. We also evaluate the detectability of a yT cross-correlation from exotic early-Universe sources in the presence of this late-time effect.

  8. Remplissage versus latarjet for engaging Hill-Sachs defects without substantial glenoid bone loss: a biomechanical comparison.

    Science.gov (United States)

    Degen, Ryan M; Giles, Joshua W; Johnson, James A; Athwal, George S

    2014-08-01

    Recurrent shoulder instability is commonly associated with Hill-Sachs defects. These defects may engage the glenoid rim, contributing to glenohumeral dislocation. Two treatment options to manage engaging Hill-Sachs defects are the remplissage procedure, which fills the defect with soft tissue, and the Latarjet procedure, which increases glenoid arc length. Little evidence exists to support one over the other. We performed a biomechanical comparison of the remplissage procedure to the traditional Latarjet coracoid transfer for management of engaging Hill-Sachs defects in terms of joint stiffness (resistance to anterior translation), ROM, and frequency of dislocation. Eight cadaveric specimens were tested on a shoulder instability simulator. Testing was performed with a 25% Hill-Sachs defect with an intact glenoid and after remplissage and Latarjet procedures. Joint stiffness, internal-external rotation ROM, and frequency of dislocation were assessed. Additionally, horizontal extension ROM was measured in composite glenohumeral abduction. After remplissage, stiffness increased in adduction with neutral rotation (12.7 ± 3.7 N/mm) relative to the Hill-Sachs defect state (8.7 ± 3.3 N/mm; p = 0.016). The Latarjet procedure did not affect joint stiffness (p = 1.0). Internal-external rotation ROM was reduced in abduction after the Latarjet procedure (49° ± 14°) compared with the Hill-Sachs defect state (69° ± 17°) (p = 0.009). Horizontal extension was reduced after remplissage (16° ± 12°) relative to the Hill-Sachs defect state (34° ± 8°) (p = 0.038). With the numbers available, there was no difference between the procedures in terms of the frequency of dislocation after reconstruction: 84% of specimens (27 of 32 testing scenarios) stabilized after remplissage, while 94% of specimens (30 of 32 testing scenarios) stabilized after the Latarjet procedure. Both procedures proved effective in reducing the frequency of dislocation in a 25% Hill-Sachs defect model

  9. Theodore von Karman

    Science.gov (United States)

    1950-01-01

    Dr. Theodore von Karman, co-founder of the Jet Propulsion Laboratory (JPL) Pasadena, California was an aeronautical theoretician. His contributions in the fields of aerodynamics and aeronautical engineering are well documented and well known to every aerospace engineer. He was the first winner of the prestigious U.S. Medal of Science presented to him by President John F. Kennedy. As well as being co-founder of JPL, he also was principal founder of a major rocket propulsion firm (Aerojet-General Corp.), the top science advisor to the U.S. Air Force during its transition to jet propulsion aircraft and the top science advisor to NATO. He was, during much of this time, the fountainhead of aerodynamic thought as head of the Guggenheim Aeronautical Laboratory at the California Institute of Technology (GALCIT) in Pasadena, California. In the May 1956 issue of the Journal of Aeronautical Sciences, it was said of him that 'No other man has had so great an impact on the development of aeronautical science in this country. Hundreds of young men became his students and scientific collaborators and were inspired to greater effort.' Dr. William H. Pickering, then director of JPL said in 1960 'We wouldn't have an aeronautical science as we know it today, if it weren't for Dr. Thoedore von Karman.' Under his guidance, Caltech's 10 foot wind tunnel was designed, built and operated. Industry firms such as Douglas, Northrop, Hughes, Lockheed, North American, Vultee and Consolidated all tested new aeronautical designs and concepts in GALCIT's tunnel. Even Boeing's own high-speed wind tunnel was heavily influenced by suggestions from von Karman. The National Advisory Committee for Aeronautics (NACA) became so concerned about GALCIT's growing influence over West coast aviation, it erected the Ames Laboratory in Sunnyvale, California in part to deter an ever widening aeronautical gap that had formed between NACA and GALCIT. From 1936 to 1940, Caltech stood alone as the only university

  10. Acquired von Willebrand Syndrome

    Institute of Scientific and Technical Information of China (English)

    郭涛

    2005-01-01

    @@ Acquired von Willebrand syndrome (AvWS) is kind of bleeding disorder with laboratory findings similar to those in congenital yon Willebrand disease (vWD).AvWS doesn's have any personal or family history of bleeding, but is associated with certain diseases or abnormal conditions or drugs. Although AvWS is being stated as a rare disease, it has gained more and more attention during the past years. Not because of the severity of the disease, but it is more common than we thought and most patients don' t have a proper diagnosis.

  11. Struktur von ABCE1

    OpenAIRE

    Karcher, Annette

    2007-01-01

    ABCE1 ist ein Mitglied der ATP Binding Cassette (ABC) Superfamilie. ABC Proteine binden und hydrolysieren ATP und verändern dabei ihre Konformation. Dadurch können sie mechanochemische Arbeit leisten. Durch drei zusätzliche Domänen unterscheidet sich ABCE1 von allen bislang bekannten und charakterisierten Mitgliedern dieser Familie. Neben den ATP-bindenden Regionen enthält ABCE1 eine cysteinreiche, N-terminale Domäne, welche zwei Eisen-Schwefel-Cluster bindet. Diese Domäne hat hohe s...

  12. The Bondi-Sachs metric at the vertex of a null cone: axially symmetric vacuum solutions

    CERN Document Server

    Mädler, Thomas

    2012-01-01

    In the Bondi-Sachs formulation of General Relativity space-time is foliated via a family of null cones. If these null cones are defined such that their vertices are traced by a regular world-line then the metric tensor has to obey regularity conditions at the vertices. We explore these regularity conditions when the world line is a time-like geodesic. In particular, we solve the Einstein equations for the Bondi-Sachs metric near the vertices for axially symmetric vacuum space- times. The metric is calculated up to third order corrections with respect to a flat metric along the time-like geodesic, as this is the lowest order where non- linear coupling of the metric coefficients occurs. We also determine the boundary conditions of the metric to arbitrary order of these corrections when a linearized and axially symmetric vacuum space-time is assumed. In both cases we find that (i) the initial data on the null cone must have a very rigid angular structure for the vertex to be a regular point, and (ii) the initial...

  13. Geodesic completeness and the lack of strong singularities in effective loop quantum Kantowski-Sachs spacetime

    Science.gov (United States)

    Saini, Sahil; Singh, Parampreet

    2016-12-01

    Resolution of singularities in the Kantowski-Sachs model due to non-perturbative quantum gravity effects is investigated. Using the effective spacetime description for the improved dynamics version of loop quantum Kantowski-Sachs spacetimes, we show that even though expansion and shear scalars are universally bounded, there can exist events where curvature invariants can diverge. However, such events can occur only for very exotic equations of state when pressure or derivatives of energy density with respect to triads become infinite at a finite energy density. In all other cases curvature invariants are proved to remain finite for any evolution in finite proper time. We find the novel result that all strong singularities are resolved for arbitrary matter. Weak singularities pertaining to above potential curvature divergence events can exist. The effective spacetime is found to be geodesically complete for particle and null geodesics in finite time evolution. Our results add to a growing evidence for generic resolution of strong singularities using effective dynamics in loop quantum cosmology by generalizing earlier results on isotropic and Bianchi-I spacetimes.

  14. AAV gene therapy in a sheep model of Tay-Sachs disease.

    Science.gov (United States)

    Gray-Edwards, Heather; Randle, Ashley N; Maitland, Stacy; Benatti, Hector; Hubbard, Spencer; Canning, Peter; Vogel, Matthew; Brunson, Brandon; Hwang, Misako; Ellis, Lauren; Bradbury, Allison M; Gentry, Atoska; Taylor, Amanda; Wooldridge, Anne; Wilhite, Dewey; Winter, Randoplh; Whitlock, Brain; Johnson, Jacob A; Holland, Merrilee; Salibi, Nouha; Beyers, Ronald; Sartin, James; Denney, Thomas; Cox, Nancy R; Sena-Esteves, Miguel; Martin, Douglas R

    2017-09-19

    Tay-Sachs disease (TSD) is a fatal neurodegenerative disorder caused by a deficiency of the enzyme hexosaminidase A (HexA). Tay-Sachs disease also occurs in sheep, the only experimental model of TSD that has clinical signs of disease. The natural history of sheep TSD was characterized using serial neurological evaluations, 7 tesla MRI, echocardiograms, electrodiagnostics and cerebrospinal fluid (CSF) biomarkers. Intracranial gene therapy was also tested using AAVrh8 monocistronic vectors encoding the α subunit of Hex (TSD α) or a mixture of two vectors encoding both the α and β subunits separately (TSD α+β) injected at high (1.3 x1013vg) or low (4.2x1012vg) dose. Delay of symptom onset and/or reduction of acquired symptoms were noted in all AAV treated sheep. Post-mortem evaluation showed superior HexA and vector genome distribution in the brain of TSD α+β sheep compared to TSD α sheep, but spinal cord distribution was low in all groups. Isozyme analysis showed superior HexA formation after treatment with both vectors (TSD α+β) and ganglioside clearance was most widespread in the TSD α+β high dose sheep. Microglial activation and proliferation in TSD sheep - most prominent in the cerebrum - were attenuated after gene therapy. This report demonstrates therapeutic efficacy for TSD in the sheep brain, which is in the same order of magnitude as a child's brain.

  15. A note on proper affine symmetry in Kantowski-Sachs and Bianchi type III space-times

    CERN Document Server

    Shabbir, Ghulam

    2016-01-01

    We investigate proper affine symmetry for the Kantowski-Sachs and Bianchi type III space-times by using holonomy and decomposability, the rank of the 6X6 Riemann matrix and direct integration techniques. It is shown that the very special classes of the above space-times admit proper affine vector fields.

  16. A note on classification of proper homothetic vector fields in Kantowski-Sachs and Bianchi type III Lorentzian manifolds

    CERN Document Server

    Shabbir, Ghulam

    2011-01-01

    A complete study of Kantowski-Sachs and Bianchi type III space-times according to their proper homothetic vector fields is given by using direct integration technique. Using the above mentioned technique we have shown that very special classes of the above space-times admit proper homothetic vector fields. The dimension of homothetic vector fields is five.

  17. The pre-Anschluss Vienna School of Medicine - the physicians: Sigmund Freud (1856-1939), Julius Wagner-Jauregg (1857-1940) and Karel Wenckebach (1864-1940).

    Science.gov (United States)

    Shaw, Lily Bzl; Shaw, Robert A

    2016-05-01

    Three physicians are discussed. Sigmund Freud, probably the best-known member of the Vienna School of Medicine, was the path-breaking pioneer in psychoanalysis and psychotherapy. Julius Wagner-Jauregg was a psychiatrist who discovered the link between iodine deficiency and goitre and also developed malaria therapy to treat progressive paralysis caused by syphilis for which he was awarded the Nobel Prize. Karel Wenckebach, the pioneering Dutch cardiologist, is best known for the Wenckebach block. After the Anschluss, fate dealt very different hands to these three physicians. Freud fled to London where he soon died. Wagner-Jauregg, who had some pan-Germanic sympathies as well as views on eugenics, left a controversial legacy. The Dutch cardiologist Wenckebach died in Vienna shortly after his homeland had been invaded in 1940 by that of his hosts. © IMechE 2014.

  18. Alejandro Von Humboldt

    Directory of Open Access Journals (Sweden)

    Gerardo Paz Otero

    1965-09-01

    Full Text Available Diverso fue y sigue siéndolo, el destino de los dos hermanos Humboldt, Guillermo y Alejandro. Sino que se inicia con el nacimiento: Guillermo, el mayor, nace el 22 de junio de 1767 en Potsdam, residencia de los emperadores prusianos, la ciudad de los palacios imperiales, el imperio del militarismo germano; su cuna se meció cerca al palacete de Sans-Soussi, donde Federico el Grande forja ba el poderío de Prusia, cultivaba las ciencias y las artes, anfitrionaba a los intelectuales de Europa, y era "vasallo espiritual de Volta ire", según la aguda frase de Goethe. Alejandro viene al mundo dos años después (14 de septiembre de 1769 en Berlín, en la casa burguesa de la Jagerstrasse (calle del cazador que su madre Elizabeth von Humboldt heredara de su primer esposo.

  19. Mikrochirurgische Entfernung von Hirnstammkavernomen

    Directory of Open Access Journals (Sweden)

    Pfisterer W

    2002-01-01

    Full Text Available Der Anteil der Kavernome an allen intrakraniellen vaskulären Malformationen beträgt 14 %. Davon liegen etwa 20 % im Hirnstamm. Bei einer Rezidivblutungsrate von 21 % jährlich ist auch eine Exstirpation im Hirnstamm indiziert. Wir berichten über 3 Patienten mit Hirnstammkavernomen, die in mikrochirurgischer Technik bei geringer Morbidität und ohne Mortalität an unserer Abteilung total exstirpiert wurden. Wir halten die subakute Phase für den besten Zeitpunkt zur Entfernung des Kavernoms, wenn dies der klinisch-neurologische Zustand des Patienten erlaubt. Die mikrochirurgische Exstirpation wurde durch Elektrophysiologie (akustisch und somatosensorisch evozierte Potentiale, Endoskopie und Neuronavigation unterstützt.

  20. The biomechanical effect of shoulder remplissage combined with Bankart repair for the treatment of engaging Hill-Sachs lesions.

    Science.gov (United States)

    Argintar, Evan; Heckmann, Nathanael; Wang, Lawrence; Tibone, James E; Lee, Thay Q

    2016-02-01

    The purpose of this study was to determine the biomechanical effects of the remplissage repair combined with Bankart repair for engaging Hill-Sachs lesions on range of motion (ROM), translation, and glenohumeral kinematics. Six cadaveric shoulders were tested using a custom shoulder testing system. ROM, kinematics, and anterior-posterior (AP) and superior-inferior glenohumeral translations were quantified at 0° and 60° glenohumeral abduction. Six conditions were tested: intact, Bankart lesion, Bankart with 40 % Hill-Sachs lesion, Bankart repair, Bankart repair with remplissage, and remplissage repair alone. Humeral external rotation (ER) and total range of motion increased significantly after the creation of the Bankart lesion at both 0° and 60° abduction. The Bankart repair restored ER to intact values at 0° and 60° abduction, and the addition of the remplissage repair did not significantly alter range of motion from the Bankart repair alone. AP translation increased following the creation of the Bankart and Hill-Sachs lesions and was restored with the Bankart repair; the remplissage did not alter translation from the Bankart repair alone. At maximum ER at 60° abduction, the apex of the humeral head shifted posteriorly and inferiorly with remplissage repair. The addition of the remplissage procedure combined with Bankart repair for treatment of large Hill-Sachs lesions had no statistically significant effect on ROM or translation, but altered the kinematics of the glenohumeral joint. Thus, by addressing the humeral bone defect following an anterior shoulder dislocation, the remplissage technique with concurrent Bankart repair may be a relatively minimally invasive option for converting engaging Hill-Sachs lesions to non-engaging and promoting shoulder stability, though further biomechanical and clinical studies are warranted.

  1. von Willebrand Disease (For Parents)

    Science.gov (United States)

    ... to classify the type of von Willebrand disease platelet function tests, which determine how well the platelets work ... for pain or fever. These drugs interfere with platelet function and can increase the risk of bleeding. It ...

  2. Kleben von Kunststoff mit Metall

    CERN Document Server

    Brockmann, W; Käufer, H

    1989-01-01

    Das Buch behandelt das Kleben von Kunststoffen mit Metallen in einer fur den Praktiker verstandlichen und umsetzbaren Form. Es leitet zu Klebeverfahren an, die optimale Ergebnisse hinsichtlich Qualitat, Dauerhaftigkeit und Wirtschaftlichkeit liefern.

  3. Planung und Bewertung von Montagesystemen

    Science.gov (United States)

    Hartel, Marko; Lotter, Bruno

    Die Gestaltung von Montagesystemen ist eine wesentliche Aufgabenstellung an die planenden Bereiche eines Unternehmens. Anhand von Praxis-beispielen werden Planungssystematiken and Bewertungsverfahren — sei es fur die Effizienzsteigerung einer bestehenden Montage oder die Entscheidung zwischen Varianten eines geplanten Montagesystems — aufzeigt. Die folgende Planungssystematik nach REFA wird für Produktionssysteme im Allgemeinen angewandt; die Planungssystematik nach Lotter ist speziell auf Montagesysteme ausgelegt.

  4. Theorie und Praxis von Hochschulrankings

    OpenAIRE

    Hornbostel, Stefan

    2007-01-01

    Der Beitrag gibt einen Überblick über die theoretische Grundlage von Hochschulrankings, welche in der qualitativ stark differenzierten Hochschullandschaft in Deutschland entscheidend für öffentliche Reputationsurteile sein können. Ausgehend von einem formal gleichrangigen Institutionengefüge der Hochschullandschaft in Deutschland haben die Stichworte Profilbildung, Exzellenz und Wettbewerb in den letzten Jahren zunehmend an Bedeutung gewonnen. Der daraus resultierende große Informationsbedarf...

  5. Kantowski-Sachs Universe in the Varying Speed of Light Theory

    CERN Document Server

    Khadekar, G S; Ray, Saibal

    2016-01-01

    In this work we consider the Kantowski-Sachs (KS) universe in the framework of varying speed of light theory. We present the general solutions of the gravitational field equations with variable speed of light $c(t)$, gravitational coupling parameter $G(t)$ and the decaying vacuum energy $\\Lambda(t)$ for the KS model. In the limiting case for the equation of state (EOS) parameter $\\gamma=2$ (stiff fluid with $p=\\rho c^2$) and $\\gamma =1$ (dust with $p=0$), exact solutions of the field equations are obtained. The numerical solutions are also presented for both the cases. Moreover, it is shown that in the limiting case of large time, the mean anisotropy parameter tends to zero for $\\gamma=2$ and $\\gamma=1$. Thus the time variation of the fundamental constants provides an effective mechanism for the isotropization of the KS universe.

  6. Kantowski-Sachs Universe Models in $f(T)$ Theory of Gravity

    CERN Document Server

    Amir, M Jamil

    2015-01-01

    The $f(T)$ theory is recently proposed to explain the present cosmic accelerating expansion of the universe. $f(T)$ theory is an extension of Teleparallel theory of gravity, where $T$ is the torsion scalar. This paper contains the construction of $f(T)$ models within the Kantowski-Sachs universe. For this purpose, we use conservation equation and equation of state parameter, which represents the different phases of the universe. We discuss possible cases for the matter dominated era, radiation dominated era, present dark energy phase and their combinations. Particularly, a constant solution has been obtained which may correspond to the cosmological constant. Further, we consider two well known $f(T)$ models and derive the equation of state parameter and discuss the cosmic acceleration. Also, the Hubble parameter and average scale factor have been evaluated.

  7. (Non) singular Kantowski-Sachs Universe from quantum spherically reduced matter

    CERN Document Server

    Nojiri, S; Odintsov, S D; Osetrin, K E

    1999-01-01

    Using s-wave and large $N$ approximation the one-loop effective action for 2d dilaton coupled scalars and spinors which are obtained by spherical reduction of 4d minimal matter is found. Quantum effective equations for reduced Einstein gravity are written. Their analytical solutions corresponding to 4d Kantowski-Sachs (KS) Universe are presented. For quantum-corrected Einstein gravity we get non-singular KS cosmology which represents 1) quantum-corrected KS cosmology which existed on classical level or 2)purely quantum solution which had no classical limit. The analogy with Nariai BH is briefly mentioned. For purely induced gravity (no Einstein term) we found general analytical solution but all KS cosmologies under discussion are singular. The corresponding equations of motion are reformulated as classical mechanics problem of motion of unit mass particle in some potential $V$.

  8. Kantowski-Sachs cosmological solutions in the generalized teleparallel gravity via Noether symmetry

    Science.gov (United States)

    Motavalli, H.; Akbarieh, A. Rezaei; Nasiry, M.

    2016-04-01

    We study the f(T) theory as an extension of teleparallel gravity and consider the Noether symmetry of Kantowski-Sachs (KS) anisotropic model for this theory. We specify the explicit teleparallel form of f(T) and find the corresponding exact cosmological solutions under the assumption that the Lagrangian admits the Noether symmetry. It is found that the universe experiences a power law expansion for the scale factors in the context of f(T) theory. By deriving equation of state (EOS) parameter, we show that the universe passes through the phantom and ΛCDM theoretical scenarios. In this way, we estimate a lower limit age for the universe in excellent agreement with the value reported from recent observations. When KS model reduces to the flat Friedmann-Robertson-Walker (FRW) metric, our results are properly transformed into the corresponding values.

  9. An Optimal Approach for Measuring the Integrated Sachs-Wolfe Effect

    CERN Document Server

    Dupe, F -X; Starck, J -L; Fadili, M J

    2010-01-01

    One of the main challenges of modern cosmology is to understand the primordial fluctuations of the early Universe and the nature of the mysterious dark energy which causes the cosmic acceleration. The Integrated Sachs-Wolfe (ISW) effect is sensitive to dark energy, and if reconstructed can be used to study primordial fluctuations in the CMB. The ISW effect occurs on large scales, where there are large amounts of missing data in the CMB and large scale structure maps. Moreover, existing methods in the literature often make strong assumptions about the statistics of the underlying fields or estimators. Together these effects can severely limit signal extraction. We define an optimal statistical method for detecting the ISW effect, which can handle large areas of missing data and minimise the number of underlying assumptions made about the data and estimators. We first review current detections (and non-detections) of the ISW effect, comparing the statistical subtleties of different methods found in the literatu...

  10. Two-oscillator Kantowski-Sachs model of the Schwarzschild black hole interior

    Science.gov (United States)

    Djordjevic, Goran S.; Nesic, Ljubisa; Radovancevic, Darko

    2016-08-01

    In this paper the interior of the Schwarzschild black hole, which is presented as a vacuum, homogeneous and anisotropic Kantowski-Sachs minisuperspace cosmological model, is considered. Lagrangian of the model is reduced by a suitable coordinate transformation to Lagrangian of two decoupled oscillators with the same frequencies and with zero energy in total (an oscillator-ghost-oscillator system). The model is presented in a classical, a p-adic and a noncommutative case. Then, within the standard quantum approach Wheeler-DeWitt equation and its general solutions, i.e. a wave function of the model is written, and then an adelic wave function is constructed. Finally, thermodynamics of the model is studied by using the Feynman-Hibbs procedure.

  11. Community-based genetic education, communication channels, and knowledge of Tay-Sachs disease.

    Science.gov (United States)

    Massarik, F; Kaback, M M; Greenwald, S; Nathan, T J; Rosenthal, M; Bass, D M

    1977-01-01

    In the planning of community-based genetics education campaigns, we cannot assume the existence of a single-minded, passively receptive public, simply waiting to be "educated." Rather, we must consider the impact of preexisting circumstances, notably the differential life-status conditions, the special concerns, and individual motivations of the persons to be educated on their search for information that matters to them. Messages promulgated by mass media educational campaigns on issues in genetics typically do not fall on a homogeneous mass of equally responsive ears and eyes, even if the target population superficially appears to be homogeneous and preselected. Especially institutional sources, (e.g., schools and general education) for males, and social relations (e.g., informal contact among friends) for females are crucial strategic variables affecting transmission and reception of knowledge of Tay-Sachs disease.

  12. Cross-correlation between thermal Sunyaev-Zeldovich effect and the integrated Sachs-Wolfe effect

    Science.gov (United States)

    Creque-Sarbinowski, Cyril; Bird, Simeon; Kamionkowski, Marc

    2016-09-01

    Large-angle fluctuations in the cosmic microwave background temperature induced by the integrated Sachs-Wolfe effect and Compton-y distortions from the thermal Sunyaev-Zeldovich (tSZ) effect are both due to line-of-sight density perturbations. Here we calculate the cross-correlation between these two signals. Measurement of this cross-correlation can be used to test the redshift distribution of the tSZ distortion, which has implications for the redshift at which astrophysical processes in clusters begin to operate. We also evaluate the detectability of a y T cross-correlation from exotic early-Universe sources in the presence of this late-time effect.

  13. Probing the integrated Sachs-Wolfe effect using embedded lens models

    CERN Document Server

    Chen, Bin

    2015-01-01

    The photometry profile of the integrated Sachs-Wolfe (ISW) effect recently obtained by the Planck consortium by stacking patches of Cosmic Microwave Background (CMB) sky maps around a large number of cosmic voids, contains a cold ring at about half the void's effective radius surrounded by a hot ring near the void's boundary. The source of the temperature structure is assumed to be the ISW effect but the exact cause of the ringed structure is not currently well understood, particularly the outer hot ring. Numerical simulations have suggested that hot/cold ring structures can be produced by motions associated with nonlinear growths of cosmic structures whose gravitational potentials produce the ISW effect. We have recently developed the embedded lens theory and the Fermat potential formalism which can be used to model the ISW effect caused by intervening individual lens inhomogeneities evolving arbitrarily. This theory only requires knowledge of the void's projected mass profile as a function of the passing CM...

  14. Two-oscillator Kantowski-Sachs model of the Schwarzschild black hole interior

    CERN Document Server

    Djordjevic, Goran S; Radovancevic, Darko

    2015-01-01

    In this paper the interior of the Schwarzschild black hole, which is presented as a vacuum homogeneous and anisotropic Kantowski-Sachs minisuperspace cosmological model, is considered. Lagrangian of the model is reduced by a suitable coordinate transformation to Lagrangian of two decoupled oscillators with the same frequencies and with zero energy in total (an oscillator-ghost-oscillator system). The model will be presented in a classical, a p-adic and a noncommutative case. Then, within the standard quantum approach Wheeler-DeWitt equation and its general solutions, i.e. a wave function of the model, will be written, and then an adelic wave function will be constructed. Finally, thermodynamics of the model will be studied by using the Feynman-Hibbs procedure.

  15. Hill-Sachs lesion location: does it play a role in engagement?

    Energy Technology Data Exchange (ETDEWEB)

    Gyftopoulos, Soterios; Wang, Annie; Babb, James [NYU Langone Medical Center, Department of Radiology, New York, NY (United States)

    2015-08-15

    To see if there is an association between engagement on physical examination (PE) and the location of the Hill-Sachs lesion (HSL) as assessed by the modified biceps angle. Sixty-two patients with a history of anterior shoulder dislocation, who underwent preoperative MRI and arthroscopy at our institution and were tested for engagement on PE, were collected. Two musculoskeletal radiologists reviewed the MR studies, noting the presence of an HSL and documenting the location of the HSL with the modified biceps angle. Statistical analysis included the Mann-Whitney (MW) test and ROC (receiver-operating characteristic) curve. Of 62 patients, there were 58 males and 4 females with a mean age of 30 (range 18-59 years). Twenty patients demonstrated engagement on PE, while 42 did not. All patients had evidence of an HSL on MRI and arthroscopy. The mean biceps angle for the engaging group was 151.5 ± 13.9 , and 142.4 ± 17.3 for the non-engaging group. The biceps angle was statistically significantly higher among patients who had engagement compared to those who did not (p = 0.027). Overall, diagnostic accuracy was highest for a biceps angle >149 , which resulted in a sensitivity of 70 % and specificity of 67 %. The modified biceps angle, as measured on MRI, was significantly higher in patients who demonstrated engagement on physical examination than in those who did not. This supports the theory that the location of the Hill-Sachs lesion may play a role in engagement and may be its most important characteristic when determining its significance. (orig.)

  16. Unilaterally and rapidly progressing white matter lesion and elevated cytokines in a patient with Tay-Sachs disease.

    Science.gov (United States)

    Hayase, Tomomi; Shimizu, Jun; Goto, Tamako; Nozaki, Yasuyuki; Mori, Masato; Takahashi, Naoto; Namba, Eiji; Yamagata, Takanori; Momoi, Mariko Y

    2010-03-01

    We report the case of a girl with Tay-Sachs disease who had convulsions and deteriorated rapidly after an upper respiratory infection at the age of 11 months. At the age of 16 months, her seizures became intractable and magnetic resonance imaging of the brain showed high signal intensity on T2-weighted images and marked swelling in the white matter and basal nucelei of the right hemisphere. Her seizures and right hemisphere lesion improved with glycerol and dexamethasone treatment. When dexamethasone was discontinued, her symptoms worsened and lesions later appeared in the left hemisphere. Her cerebrospinal fluid showed elevated levels of the cytokines TNF-alpha and IL-5. It is considered that inflammation contributes to disease progression in Tay-Sachs disease.

  17. Coordinate-Invariant Lyddane-Sachs-Teller Relationship for Polar Vibrations in Materials with Monoclinic and Triclinic Crystal Systems.

    Science.gov (United States)

    Schubert, Mathias

    2016-11-18

    A coordinate-invariant generalization of the Lyddane-Sachs-Teller relation is presented for polar vibrations in materials with monoclinic and triclinic crystal systems. The generalization is derived from an eigendielectric displacement vector summation approach, which is equivalent to the microscopic Born-Huang description of polar lattice vibrations in the harmonic approximation. An expression for a general oscillator strength is also described for materials with monoclinic and triclinic crystal systems. A generalized factorized form of the dielectric response characteristic for monoclinic and triclinic materials is proposed. The generalized Lyddane-Sachs-Teller relation is found valid for monoclinic β-Ga_{2}O_{3}, where accurate experimental data became available recently from a comprehensive generalized ellipsometry investigation [Phys. Rev. B 93, 125209 (2016)]. Data for triclinic crystal systems can be measured by generalized ellipsometry as well, and are anticipated to become available soon and results can be compared with the generalized relations presented here.

  18. Vergleich von simulierten und reellen Schleppkurven von Landmaschinen

    Directory of Open Access Journals (Sweden)

    Steffen Hürter

    2014-02-01

    Full Text Available An das landwirtschaftliche Wegenetz werden durch die kontinuierliche Größenentwicklung von Landmaschinen neue Anforderungen gestellt. Die Maschinen werden breiter und länger und besitzen mehr Achsen und komplexere Lenksysteme als in der Vergangenheit. Beim landwirtschaftlichen Wegebau hat dies insbesondere Auswirkungen auf die Planung der Kurven. In der Untersuchung wurden die Schleppkurven aktueller Landmaschinen aufgenommen und es wurde geprüft, ob sie mithilfe einer Software simuliert werden können. Dabei zeigt sich, dass die verwendete Simulationssoftware für die Bestimmung von Schleppkurven für Landmaschinen mit komplexen Lenksystemen hinreichend genau ist.

  19. The molecular basis of HEXA mRNA deficiency caused by the most common Tay-Sachs disease mutation.

    OpenAIRE

    Boles, D. J.; Proia, R L

    1995-01-01

    Tay-Sachs disease (TSD) is a catastrophic neurodegenerative disorder caused by mutations in the HEXA gene. The most common TSD allele worldwide contains a 4-bp insertion in exon 11 that produces a downstream premature termination codon. Despite normal transcription of this allele, HEXA mRNA is severely reduced, indicating that the HEXA transcript must be unstable. Minigenes of HEXA were constructed and expressed in mouse L cells, to investigate the relationship between the 4-bp insertion and ...

  20. A poeta das “moradas da morte”. Sobre a obra lírica de Nelly Sachs

    Directory of Open Access Journals (Sweden)

    Helmut Galle

    2006-12-01

    Full Text Available Der Artikel behandelt die deutschsprachige Dichterin Nelly Sachs, die 1966 mit Shmuel Agnon den Nobelpreis für Literatur erhielt. In der Absicht, die Gründe für die Entscheidung der Jury zu beleuchten, wird ein Überblick über Leben und Werk der Autorin gegeben und einige ausgewählte Gedichte analysiert.

  1. Ethnographische Filme und die Darstellung von Frauen

    Directory of Open Access Journals (Sweden)

    Judith Keilbach

    2002-03-01

    Full Text Available In dieser Filmographie werden ethnographische und koloniale Filme aus dem Bestand des Nederlands Filmmuseum kommentiert, die für die Frage nach der Darstellung von Frauen und Geschlechterverhältnissen von Interesse sind.

  2. Bibliographie der Werke von Herbert Spencer

    OpenAIRE

    Schmid, Michael (Prof.)

    1991-01-01

    Bibliographie der Werke von Herbert Spencer / bearb., hrsg., mit e. Einl. u. e. Kurzbiogr. vers. von Michael Schmid u. Margit Weihrich. - München : Inst. für Soziologie u. Gesellschaftspolitik, Univ. d. Bundeswehr, 1991. - 159 S.

  3. GM2-Gangliosidosis (Sandhoff and Tay Sachs disease): Diagnosis and Neuroimaging Findings (An Iranian Pediatric Case Series).

    Science.gov (United States)

    Karimzadeh, Parvaneh; Jafari, Narjes; Nejad Biglari, Habibeh; Jabbeh Dari, Sayena; Ahmad Abadi, Farzad; Alaee, Mohammad-Reza; Nemati, Hamid; Saket, Sasan; Tonekaboni, Seyed Hasan; Taghdiri, Mohammad-Mahdi; Ghofrani, Mohammad

    2014-01-01

    GM2-Gangliosidosis disease is a rare autosomal recessive genetic disorder that includes two disorders (Tay-Sachs and Sandhoff disease).These disorders cause a progressive deterioration of nerve cells and inherited deficiency in creating hexosaminidases A, B, and AB. Patients who were diagnosed withGM2-Gangliosidosis in the Neurology Department of Mofid Children's Hospital in Tehran, Iran from October 2009 to February 2014were included in our study. The disorder was confirmed by neurometabolic and enzyme level detection of hexosaminidases A, B, and AB in reference to Wagnester Laboratory in Germany. We assessed age, gender, past medical history, developmental status, clinical manifestations, and neuroimaging findings of 9 patients with Sandhoff disease and 9 with Tay Sachs disease. 83% of our patients were the offspring of consanguineous marriages. All of them had a developmental disorder as a chief complaint. 38%of patients had a history of developmental delay or regression and 22% had seizures. The patients with Sandhoff and Tay Sachs disease were followed for approximately 5 years and the follow-up showed all patients were bedridden or had expired due to refractory seizures, pneumonia aspiration, or swallowing disorders. Neuro-imaging findings included bilateral thalamic involvement, brain atrophy, and hypo myelination in near half of our patients (48%). According to the results of this study, we suggest that cherry-red spots, hyperacusis, refractory seizures, and relative parents in children with developmental delay and/or regression should be considered for assessment of GM2-Gangliosidosis disease.

  4. Diskriminierung von Enantiomeren mit chiralen Selektoren

    OpenAIRE

    Würthner, Stefan

    2007-01-01

    Die vorliegende Dissertation befasst sich mit der systematischen Aufklärung von zwischenmolekularen Wirt-Gast-Wechselwirkungen von Arzneistoffen mit Cyclodextrinen. In einem sich trichterförmig verengenden Erkenntnisprozeß wird im ersten Schritt eine breite Datenbasis von Kapillarelektrophorese-Daten von 86 chiralen Arzneistoffen mit 3 nativen CDs (alpha, beta und gamma) sowie 11 CD-Derivaten gewonnen. Sowohl die Trennfaktoren der Enantiomeren (alpha_m) als auch die Retardierungsfaktoren (R_m...

  5. Doença de Tay-Sachs: um relato de caso

    Directory of Open Access Journals (Sweden)

    Marta Wey Vieira

    2014-10-01

    Full Text Available Introdução: a doença de Tay-Sachs (DTS é uma doença autossômica recessiva neurodegenerativa, com início na infância, sendo caracterizada pelo retardo no desenvolvimento, seguido de paralisia, demência e cegueira. É causada por uma mutação no gene HEXA, identificado no cromossomo 15q23-q244, que é responsável pela codificação da subunidade da enzima Hex A1. Essa mutação acaba por permitir que haja um acúmulo intralisossomal de gangliosídeo GM2 nas células neuronais. Objetivo: Relatar um caso de DTS do serviço de Pediatria em um hospital em Sorocaba. Descrição do Caso: paciente do sexo feminino com 5 anos de idade, encaminhada ao serviço de genética-clínica por apresentar retardo no desenvolvimento neuropsicomotor a esclarecer, cuja 2ª triagem ampliada para erros inatos do metabolismo revelou hexosaminidase A não detectável e hexosaminidase A-MUGS de 15nmol/h/mgprot (nl:150-390nmol/h/mgprot, compatível com o diagnóstico de Doença de Tay-Sachs. Comentários: há três variantes da DTS, a forma apresentada pela paciente do caso pode ser a juvenil (subaguda ou a forma adulta (crônica. O tratamento para a DTS é restringe-se ao suporte das manifestações clínicas e manejo adequado das intercorrências e doenças infecciosas com a manutenção adequada da nutrição e da hidratação, além do controle das convulsões quando estas ocorrerem. Entretanto, técnicas têm sido desenvolvidas no intuito de encontrar alguma terapia viável e efetiva, como por exemplo: terapias de reposição enzimática (TRE, terapias de moléculas pequenas chamadas chaperonas farmacológicas (PC, terapia de privação de substrato o transplante de medula óssea, terapia gênica mediada por vetor retroviral e a liberação de genes diretamente no sistema nervoso central. Conclusão: A doença de Tay-Sachs (DTS é uma doença neurodegenerativa, causada por uma mutação genética. O diagnóstico pode ser feito ainda durante o pr

  6. [Pheochromocytoma and von Recklinghausen's disease].

    Science.gov (United States)

    Rabii, R; Fekak, H; Moufid, K; Joual, A; Bennani, S; el Mrini, M; Benjelloun, S

    2002-07-01

    The association between von Recklinghausen's disease and pheochromocytoma is present about 10% of cases. We report a case of 49 years old women who presented with elevated blood pressure and von Recklinghausen's neurofibromatosis. Laboratory examination showed a marked level in the urinary excretion of cathecholamine. The computed tomography showed a right adrenal tumor suggesting a pheochromocytoma. The adrenalectomy was realised by transabdominal approach and the histological examination confirmed a benign pheochromocytoma. The authors discuss the pathogenetic hypothesis of this rare pathological association, the diagnostic methods and the therapeutic procedure.

  7. An Invitation from Lars von Trier

    DEFF Research Database (Denmark)

    Skadhauge, Troels; Tønder, Lars

    2015-01-01

    Translation of Martin Krasnik interview with Lars von Trier broadcast on DR2, January 12, 2015. The following is an interview of Lars von Trier (LvT) by the Danish journalist Martin Krasnik (MK). The interview took place in Lars von Trier’s home in Brede, a small town just outside Copenhagen...

  8. Homopteren von Java, gesammelt von Herrn Edw. Jacobson

    NARCIS (Netherlands)

    Melichar, L.

    1914-01-01

    Herr Edw. Jacobson hat auf Java in den Jahren 1908— 1910 Homopteren gesammelt und mir die Bearbeitung des gesammelten Materiales übertragen. Die Jacobson’sche Ausbeute ist insoferne bemerkenswert, als dieselbe viele Mikrohomopteren enthält, welche von nichtfachkundigen Sammlern gewöhnlich nicht

  9. Homopteren von Java, gesammelt von Herrn Edw. Jacobson

    NARCIS (Netherlands)

    Melichar, L.

    1914-01-01

    Herr Edw. Jacobson hat auf Java in den Jahren 1908— 1910 Homopteren gesammelt und mir die Bearbeitung des gesammelten Materiales übertragen. Die Jacobson’sche Ausbeute ist insoferne bemerkenswert, als dieselbe viele Mikrohomopteren enthält, welche von nichtfachkundigen Sammlern gewöhnlich nicht beac

  10. Integration von Erkennung und Interpretation von gesprochener Sprache

    OpenAIRE

    Fink, Gernot A.; Kummert, Franz; Sagerer, Gerhard; Kunze, Jürgen

    1994-01-01

    Die Mehrzahl der heutigen sprachverstehenden Systeme sind aus zwei sehr unterschiedlichen Verarbeitungskomponenten aufgebaut, einer meist statistischen Spracherkennungskomponente und einer in der Regel wissensbasiert arbeitenden Komponente zur Interpretation. Die Kommunikation zwischen diesen Verarbeitungseinheiten ist stark eingeschränkt. In der Regel werden von der Spracherkennung nur Worthypothesenmengen berechnet und an die Interpretationskomponente weitergereicht ohne weitere Interaktion...

  11. Identification of novel mutations in HEXA gene in children affected with Tay Sachs disease from India.

    Directory of Open Access Journals (Sweden)

    Mehul Mistri

    Full Text Available Tay Sachs disease (TSD is a neurodegenerative disorder due to β-hexosaminidase A deficiency caused by mutations in the HEXA gene. The mutations leading to Tay Sachs disease in India are yet unknown. We aimed to determine mutations leading to TSD in India by complete sequencing of the HEXA gene. The clinical inclusion criteria included neuroregression, seizures, exaggerated startle reflex, macrocephaly, cherry red spot on fundus examination and spasticity. Neuroimaging criteria included thalamic hyperdensities on CT scan/T1W images of MRI of the brain. Biochemical criteria included deficiency of hexosaminidase A (less than 2% of total hexosaminidase activity for infantile patients. Total leukocyte hexosaminidase activity was assayed by 4-methylumbelliferyl-N-acetyl-β-D-glucosamine lysis and hexosaminidase A activity was assayed by heat inactivation method and 4-methylumbelliferyl-N-acetyl-β-D-glucosamine-6-sulphate lysis method. The exons and exon-intron boundaries of the HEXA gene were bidirectionally sequenced using an automated sequencer. Mutations were confirmed in parents and looked up in public databases. In silico analysis for mutations was carried out using SIFT, Polyphen2, MutationT@ster and Accelrys Discovery Studio softwares. Fifteen families were included in the study. We identified six novel missense mutations, c.340 G>A (p.E114K, c.964 G>A (p.D322N, c.964 G>T (p.D322Y, c.1178C>G (p.R393P and c.1385A>T (p.E462V, c.1432 G>A (p.G478R and two previously reported mutations. c.1277_1278insTATC and c.508C>T (p.R170W. The mutation p.E462V was found in six unrelated families from Gujarat indicating a founder effect. A previously known splice site mutation c.805+1 G>C and another intronic mutation c.672+30 T>G of unknown significance were also identified. Mutations could not be identified in one family. We conclude that TSD patients from Gujarat should be screened for the common mutation p.E462V.

  12. Identification of novel mutations in HEXA gene in children affected with Tay Sachs disease from India.

    Science.gov (United States)

    Mistri, Mehul; Tamhankar, Parag M; Sheth, Frenny; Sanghavi, Daksha; Kondurkar, Pratima; Patil, Swapnil; Idicula-Thomas, Susan; Gupta, Sarita; Sheth, Jayesh

    2012-01-01

    Tay Sachs disease (TSD) is a neurodegenerative disorder due to β-hexosaminidase A deficiency caused by mutations in the HEXA gene. The mutations leading to Tay Sachs disease in India are yet unknown. We aimed to determine mutations leading to TSD in India by complete sequencing of the HEXA gene. The clinical inclusion criteria included neuroregression, seizures, exaggerated startle reflex, macrocephaly, cherry red spot on fundus examination and spasticity. Neuroimaging criteria included thalamic hyperdensities on CT scan/T1W images of MRI of the brain. Biochemical criteria included deficiency of hexosaminidase A (less than 2% of total hexosaminidase activity for infantile patients). Total leukocyte hexosaminidase activity was assayed by 4-methylumbelliferyl-N-acetyl-β-D-glucosamine lysis and hexosaminidase A activity was assayed by heat inactivation method and 4-methylumbelliferyl-N-acetyl-β-D-glucosamine-6-sulphate lysis method. The exons and exon-intron boundaries of the HEXA gene were bidirectionally sequenced using an automated sequencer. Mutations were confirmed in parents and looked up in public databases. In silico analysis for mutations was carried out using SIFT, Polyphen2, MutationT@ster and Accelrys Discovery Studio softwares. Fifteen families were included in the study. We identified six novel missense mutations, c.340 G>A (p.E114K), c.964 G>A (p.D322N), c.964 G>T (p.D322Y), c.1178C>G (p.R393P) and c.1385A>T (p.E462V), c.1432 G>A (p.G478R) and two previously reported mutations. c.1277_1278insTATC and c.508C>T (p.R170W). The mutation p.E462V was found in six unrelated families from Gujarat indicating a founder effect. A previously known splice site mutation c.805+1 G>C and another intronic mutation c.672+30 T>G of unknown significance were also identified. Mutations could not be identified in one family. We conclude that TSD patients from Gujarat should be screened for the common mutation p.E462V.

  13. 基于Julius的机器人语音识别系统构建%Robot Speech Recognition System Based on Julius

    Institute of Scientific and Technical Information of China (English)

    付维; 刘冬; 闵华松

    2011-01-01

    As a result of the continuous development of robot technology, speech recognition of the robot is proposed as intelligent hu- man-computer interaction. After studying the basic principles of HMM speech recognition, in the robot platform of laboratory speech recognition system for isolated words is achieved with open source HTK and Julius. Using the speech recognition system, we can extract the voice command for robot control.%随着机器人技术不断发展,本文提出机器人的语音识别这一智能人机交互方式。在研究了基于HMM语音识别基本原理的情况下,在实验室的机器人平台上,利用HTK和Julius开源平台,构建了一个孤立词的语音识别系统。利用该语音识别系统可以提取语音命令用于机器人的控制。

  14. Sindrom Von Hippel–Lindau

    Directory of Open Access Journals (Sweden)

    E V Ershova

    2011-06-01

    Full Text Available Von Hippel-Lindau syndrome - a systemic disease manifesting with multiple tumor growth, inherited by autosomal-dominant type with high penetrance. Understanding the pathogenesis of the disease is important for determining the start time of screening for the presence of the tumors and adequate treatment, including metabolic disorders.

  15. Zur Soziologie von Ctenidium molluscum

    NARCIS (Netherlands)

    Zijlstra, Gea

    1979-01-01

    Bei einer Untersuchung in einer Anzahl von niederländischen „blauwgraslanden“ (d. h. „blaue Wiesen“, Cirsio-Molinietum, Junco-Molinion) wurde Ctenidium molluscum angetroffen, eine Art, welche in den Niederlanden mehr oder weniger zum Mesobromion gerechnet wird. Untersuchungen an altem Herbarmaterial

  16. Spontaneous appearance of Tay-Sachs disease in an animal model.

    Science.gov (United States)

    Zeng, B J; Torres, P A; Viner, T C; Wang, Z H; Raghavan, S S; Alroy, J; Pastores, G M; Kolodny, E H

    2008-01-01

    Tay-Sachs disease (TSD) is a progressive neurodegenerative disorder due to an autosomal recessively inherited deficiency of beta-hexosaminidase A (Hex A). Deficiency of Hex A in TSD is caused by a defect of the alpha-subunit resulting from mutations of the HEXA gene. To date, there is no effective treatment for TSD. Animal models of genetic diseases, similar to those known to exist in humans, are valuable and essential research tools for the study of potentially effective therapies. However, there is no ideal animal model of TSD available for use in therapeutic trials. In the present study, we report an animal model (American flamingo; Phoenicopterus ruber) of TSD with Hex A deficiency occurring spontaneously in nature, with accumulation of G(M2)-ganglioside, deficiency of Hex A enzymatic activity, and a homozygous P469L mutation in exon 12 of the hexa gene. In addition, we have isolated the full-length cDNA sequence of the flamingo, which consists of 1581 nucleotides encoding a protein of 527 amino acids. Its coding sequence indicates approximately 71% identity at the nucleotide level and about 72.5% identity at the amino acid level with the encoding region of the human HEXA gene. This animal model, with many of the same features as TSD in humans, could represent a valuable resource for investigating therapy of TSD.

  17. The Integrated Sachs-Wolfe effect in $f(R)$ gravity

    CERN Document Server

    Cai, Yan-Chuan; Cole, Shaun; Frenk, Carlos S; Neyrinck, Mark

    2013-01-01

    We study the late-time Integrated Sachs-Wolfe (ISW) effect in $f(R)$ modified gravity using N-body simulations. In the $f(R)$ model under study, the linear growth rate is larger than that in general relativity (GR) due to the enhancement of gravity. This counters the effect of cosmic acceleration at late times, thus slowing down the decay of the cosmic potential and induces a smaller ISW effect on large scales. Therefore, the $\\dot\\Phi$ (time derivative of the potential) power spectrum at the Fourier $k$ range of $k0.1h$/Mpc is increased. The difference between the $\\dot\\Phi$ power spectrum in $f(R)$ and GR reaches 100% on small scales at z=0. In contrast, the differences in the density power spectrum is only 50%. We explore the detectability of the ISW signal via stacking supervoids and superclusters in simulations. For relatively large ISW cold spots, they are less cold in $f(R)$ than in GR, while small cold spots are colder. ISW hot spots corresponding to the stacking of superclusters in $f(R)$ are not as ...

  18. Qualitative analysis of Kantowski-Sachs metric in a generic class of f(R) models

    Energy Technology Data Exchange (ETDEWEB)

    Leon, Genly [Instituto de Física, Pontificia Universidad Católica de Valparaíso, Casilla 4950, Valparaíso (Chile); Roque, Armando A., E-mail: genly.leon@ucv.cl, E-mail: arestrada@ucf.edu.cu [Grupo de Estudios Avanzados, Universidad de Cienfuegos, Carretera a Rodas, Cuatro Caminos, s/n. Cienfuegos (Cuba)

    2014-05-01

    In this paper we investigate, from the dynamical systems perspective, the evolution of a Kantowski-Sachs metric in a generic class of f(R) models. We present conditions (i.e., differentiability conditions, existence of minima, monotony intervals, etc.) for a free input function related to the f(R), that guarantee the asymptotic stability of well-motivated physical solutions, specially, self-accelerated solutions, allowing to describe both inflationary- and late-time acceleration stages of the cosmic evolution. We discuss which f(R) theories allows for a cosmic evolution with an acceptable matter era, in correspondence to the modern cosmological paradigm. We find a very rich behavior, and amongst others the universe can result in isotropized solutions with observables in agreement with observations, such as de Sitter, quintessence-like, or phantom solutions. Additionally, we find that a cosmological bounce and turnaround are realized in a part of the parameter-space as a consequence of the metric choice.

  19. Ashkenazi Jewish population screening for Tay-Sachs disease: the international and Australian experience.

    Science.gov (United States)

    Lew, Raelia M; Burnett, Leslie; Proos, Anné L; Barlow-Stewart, Kristine; Delatycki, Martin B; Bankier, Agnes; Aizenberg, Harry; Field, Michael J; Berman, Yemima; Fleischer, Ronald; Fietz, Michael

    2015-03-01

    Internationally, Tay-Sachs disease (TSD) preconception screening of Ashkenazi Jewish (AJ) individuals and couples has led to effective primary prevention of TSD. In Australia, adolescent preconception genetic screening programs operate mainly in Jewish community high schools. These existing programs offer an effective means of primary prevention of TSD, are cost effective and safe. However, in the broader Australian community TSD screening is not systematically performed and cases still occur in unscreened AJ individuals. In order to improve the effectiveness of Australian screening, there is a need for definitive guidelines for healthcare professionals to facilitate extension of the proven benefits of preconception TSD screening to all AJ individuals at risk. We performed a systematic review of the relevant literature relating to AJ pre-conception and antenatal screening for TSD. The evidence was assessed using an established National Health and Medical Research Council evidence grading system. Evaluations of efficacy of TSD screening programs design and execution, cost-benefit and cost-utility health economic evaluation, and population outcomes were undertaken. The results have been used to propose a model for universal AJ TSD preconception and antenatal screening for the primary care setting. © 2014 The Authors. Journal of Paediatrics and Child Health © 2014 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

  20. Three novel mutations in Iranian patients with Tay-Sachs disease.

    Science.gov (United States)

    Jamali, Solmaz; Eskandari, Nasim; Aryani, Omid; Salehpour, Shadab; Zaman, Talieh; Kamalidehghan, Behnam; Houshmand, Massoud

    2014-01-01

    Tay-Sachs disease (TSD), or GM2 gangliosidosis, is a lethal autosomal recessive neurodegenerative disorder, which is caused by a deficiency of beta-hexosaminidase A (HEXA), resulting in lysosomal accumulation of GM2 ganglioside. The aim of this study was to identify the TSD-causing mutations in an Iranian population. In this study, we examined 31 patients for TSD-causing mutations using PCR, followed by restriction enzyme digestion. Molecular genetics analysis of DNA from 23 patients of TSD revealed mutations that has been previously reported, including four-base duplications c.1274_1277dupTATC in exon 11 and IVS2+1G>A, deletion TTAGGCAAGGGC in exon 10 as well as a few novel mutations, including C331G, which altered Gln>Glu in HEXB, A>G, T>C, and p.R510X in exon 14, which predicted a termination codon or nonsense mutation. In conclusion, with the discovery of these novel mutations, the genotypic spectrum of Iranian patients with TSD disease has been extended and could facilitate definition of disease-related mutations.

  1. Qualitative analysis of Kantowski-Sachs metric in a generic class of $f(R)$ models

    CERN Document Server

    Leon, Genly

    2013-01-01

    In this paper we investigate, from the dynamical systems perspective, the evolution of a Kantowski-Sachs metric in a generic class of $f(R)$ models. We present conditions (i. e., differentiability conditions, existence of minima, monotony intervals, etc.) for a free input function related to the $f(R)$, that guarantee the asymptotic stability of well-motivated physical solutions, specially, self-accelerated solutions, allowing to describe both inflationary- and late-time acceleration stages of the cosmic evolution. We discuss which $f(R)$ theories allows for a cosmic evolution with an acceptable matter era, in correspondence to the modern cosmological paradigm. We find a very rich behavior, and amongst others the universe can result in isotropized solutions with observables in agreement with observations, such as de Sitter, quintessence-like, or phantom solutions. Additionally, we find that a cosmological bounce and turnaround are realized in a part of the parameter-space as a consequence of the metric choice...

  2. Detecting the integrated Sachs-Wolfe effect with high-redshift 21-cm surveys

    CERN Document Server

    Raccanelli, Alvise; Dai, Liang; Kamionkowski, Marc

    2015-01-01

    We investigate the possibility to detect the integrated Sachs-Wolfe (ISW) effect by cross-correlating 21-cm surveys at high redshifts with galaxies, in a way similar to the usual CMB-galaxy cross-correlation. The high-redshift 21-cm signal is dominated by CMB photons that travel freely without interacting with the intervening matter, and hence its late-time ISW signature should correlate extremely well with that of the CMB at its peak frequencies. Using the 21-cm temperature brightness instead of the CMB would thus be a further check of the detection of the ISW effect, measured by different instruments at different frequencies and suffering from different systematics. We also study the ISW effect on the photons that are scattered by HI clouds. We show that a detection of the unscattered photons is achievable with planned radio arrays, while one using scattered photons will require advanced radio interferometers, either an extended version of the planned Square Kilometre Array or futuristic experiments such as...

  3. Measurement of the integrated Sachs-Wolfe effect using the AllWISE data release

    CERN Document Server

    Shajib, Anowar J

    2016-01-01

    One of the physical features of a dark-energy-dominated universe is the integrated Sachs-Wolfe (ISW) effect on the cosmic microwave background (CMB) radiation, which gives us a direct observational window to detect and study dark energy. The AllWISE data release of the Wide-field Infrared Survey Explorer (WISE) has a large number of point sources, which span over a wide redshift range including where the ISW effect is maximized. AllWISE data is thus very well-suited for the ISW effect studies. In this study, we cross-correlate AllWISE galaxy and active galactic nucleus (AGN) overdensities with the Wilkinson Microwave Anisotropy Probe CMB temperature maps to detect the ISW effect signal. We calibrate the biases for galaxies and AGNs by cross-correlating the galaxy and AGN overdensities with the Planck lensing convergence map. We measure the ISW effect signal amplitudes relative to the {\\Lambda}CDM expectation of $A=1$ to be $A=1.18 \\pm 0.36$ for galaxies and $A=0.64 \\pm 0.74$ for AGNs . The detection significa...

  4. The cross-correlation between 3d cosmic shear and the integrated Sachs-Wolfe effect

    CERN Document Server

    Zieser, Britta

    2016-01-01

    We present the first calculation of the cross-correlation between three-dimensional cosmic shear and the integrated Sachs-Wolfe (iSW) effect. Both signals are combined in a single formalism, which permits the computation of the full covariance matrix. In order to avoid the uncertainties presented by the non-linear evolution of the matter power spectrum and intrinsic alignments of galaxies, our analysis is restricted to large scales, i.e. multipoles below l=1000. We demonstrate in a Fisher analysis that this reduction compared to other studies of three-dimensional weak lensing extending to smaller scales is compensated by the information that is gained if the additional iSW signal and in particular its cross-correlation with lensing data are considered. Given the observational standards of upcoming weak lensing surveys like Euclid, marginal errors on cosmological parameters decrease by ten per cent compared to a cosmic shear experiment if both types of information are combined without a CMB prior. Once the con...

  5. Correlating the CMB with Luminous Red Galaxies The Integrated Sachs-Wolfe Effect

    CERN Document Server

    Padmanabhan, N; Seljak, U; Schlegel, D J; Brinkmann, J; Schneider, D P; Padmanabhan, Nikhil; Hirata, Christopher M.; Seljak, Uros; Schlegel, David; Brinkmann, Jonathan; Schneider, Donald P.

    2004-01-01

    We present a 2.5 sigma detection of the Integrated Sachs-Wolfe (ISW) effect and discuss the constraints it places on cosmological parameters. We cross-correlate microwave temperature maps from the WMAP satellite with a 4000 deg^2 luminous red galaxy (LRG) overdensity map measured by the Sloan Digital Sky Survey. Accurate photometric redshifts allow us to perform a reliable auto-correlation analysis of the LRGs, eliminating the uncertainty in the galaxy bias, and combined with cross correlation signal, constrains cosmological parameters -- in particular, the matter density. We find a 2.5 sigma signal in the Ka, Q, V, and W WMAP bands, after combining the information from multipoles 2 <= l < 400. This is consistent with the expected amplitude of the ISW effect, but requires a lower matter density than is usually assumed: the amplitude, parametrized by the galaxy bias assuming \\Omega_M=0.3, \\Omega_\\Lambda=0.7 and \\sigma_8=0.9, is b_g = 4.05 \\pm 1.54 for V band, with similar results for the other bands. Thi...

  6. The SDSS-III Baryonic Oscillation Spectroscopic Survey: Constraints on the Integrated Sachs Wolfe effect

    CERN Document Server

    Hernandez-Monteagudo, Carlos; Cuesta, Antonio; Genova-Santos, Ricardo; Prada, Francisco; Rossi, Graziano; Neyrinck, Mark; Viel, Matteo; Rubino-Martin, Jose-Alberto; Scoccola, Claudia G; Zhao, Gongbo; Schneider, Donald P; Brownstein, Joel R; Thomas, Daniel; Brinkmann, Jonathan V

    2013-01-01

    In the context of the study of the Integrated Sachs Wolfe effect (ISW), we construct a template of the projected density distribution up to $z\\simeq 0.7$ by using the Luminous Galaxies (LGs) from the Sloan Digital Sky Survey DR8. We use a photo-z catalogue trained with more than a hundred thousand galaxies from BOSS in the SDSS DR8 imaging area. We consider two different LG samples whose selection matches that of SDSS-III/BOSS: the LOWZ sample ($z\\in [0.15,0.5]$) and the CMASS sample ($z\\in[0.4,0.7]$). When building the LG density maps we use the information from star density, survey footprint, seeing conditions, sky emission, dust extinction and airmass to explore the impact of these artifacts on the two LG samples. In agreement with previous studies, we find that the CMASS sample is particularly sensitive to Galactic stars, which dominate the contribution to the auto-angular power spectrum below $\\ell=7$. Other potential systematics affect mostly the low multipole range ($\\ell\\in[2,7]$), but leave fluctuati...

  7. [Friedrich Ludwig von Maydelli pildid Baltimaade ajaloost = Friedrich Ludwig von Maydells Baltische Geschichte in Bildern = Friedrich Ludwig von Maydell ́s Baltic history in images] / Ulrike Plath

    Index Scriptorium Estoniae

    Plath, Ulrike, 1972-

    2014-01-01

    Arvustus: Friedrich Ludwig von Maydelli pildid Baltimaade ajaloost = Friedrich Ludwig von Maydells Baltische Geschichte in Bildern = Friedrich Ludwig von Maydell ́s Baltic history in images. Eesti kunstimuuseum, Kadrioru kunstimuuseum. Tallinn 2013

  8. [Friedrich Ludwig von Maydelli pildid Baltimaade ajaloost = Friedrich Ludwig von Maydells Baltische Geschichte in Bildern = Friedrich Ludwig von Maydell ́s Baltic history in images] / Ulrike Plath

    Index Scriptorium Estoniae

    Plath, Ulrike, 1972-

    2014-01-01

    Arvustus: Friedrich Ludwig von Maydelli pildid Baltimaade ajaloost = Friedrich Ludwig von Maydells Baltische Geschichte in Bildern = Friedrich Ludwig von Maydell ́s Baltic history in images. Eesti kunstimuuseum, Kadrioru kunstimuuseum. Tallinn 2013

  9. Temporary Efficacy of Pyrimethamine in Juvenile-Onset Tay-Sachs Disease Caused by 2 Unreported HEXA Mutations in the Indian Population.

    Science.gov (United States)

    Udwadia-Hegde, Anaita; Hajirnis, Omkar

    2017-01-01

    Juvenile Tay-Sachs disease is rarer than other forms of Tay-Sachs disease and is usually seen in children between the age of 2 and 10 years. Pyrimethamine as a pharmacological chaperone was used to increase β-hexosaminidase A activity in this patient. We describe a patient with Tay-Sachs disease from the Indian population, a juvenile case who presented with developmental regression starting at the age of three, initially with motor followed by language regression. She is currently incapacitated with severe behavioral issues. This brief communication gives an insight into the efficacy of pharmacological chaperones. It also describes two unreported mutations in hexosaminidase A gene from the Indian population. After commencing Pyrimethamine, though initial benefits with increase in levels corresponded with briefly halting the motor regression, the observed increase was only transient and not associated with discernible beneficial neurological or psychiatric effects.

  10. Schätzung von Vegetationsparametern aus multispektralen Fernerkundungsdaten

    OpenAIRE

    2007-01-01

    In der vorliegenden Arbeit wird ein Verfahren zur Schätzung von Vegetationsparametern aus multispektralen Fernerkundungsdaten unter Verwendung von physikalischen Strahlungstransfer-Modellen und einer geringen Anzahl von Bodenmessungen vorgestellt. Dieses Verfahren wurde über einen Zeitraum von zwei Jahren exemplarisch an verschiedenen Winterweizenfeldern getestet, die mit einem Daedalus ATM Multispektralscanner aufgenommen wurden. Von besonderem Interesse sind hierbei die Schwankungen der Veg...

  11. La fotografía de Julius Shulman y la construcción de la imagen de la arquitectura del sur de California

    Directory of Open Access Journals (Sweden)

    Daniel Díez Martínez

    2014-10-01

    Full Text Available A Julius Shulman le correspondió, casi en exclusiva, la labor de cronista gráfico de la arquitectura moderna en el sur de California. Consciente de la dificultad de hacer ver al público la belleza de estas construcciones, Shulman desarrolló un lenguaje propio con un marcado sentido escenográfico, un encuentro entre la fotografía arquitectónica clásica y la publicidad contemporánea inspirada en la cultura pop en la que la colocación de los muebles en intervalos estratégicos, la iluminación, la elección y actitud de los modelos o la vegetación estaban cuidadosamente estudiados para guiar la vista del espectador hacia la arquitectura y el estilo de vida que de esta se desprendía. El artículo propone una visión transversal de la fotografía de Shulman y establece lazos entre su obra y la tensión política que se respiraba en los Estados Unidos de la Guerra Fría. Gracias a las “escenas” capturadas en sus fotografías, la arquitec­tura moderna californiana quedaría por siempre asociada al contexto creado por el fotógrafo, dando lugar a imágenes que el tiempo ha elevado a la categoría de iconos culturales del siglo XX. Como la arquitectura que retrataba, la fotografía se convirtió en una exaltación de la modernidad entendida como una nueva era de bienestar, prosperidad y progreso.

  12. [Knowledge of German neurologists on migraine around 1890. Paul Julius Möbius and his 1894 monograph Die Migräne].

    Science.gov (United States)

    Schobeß, C; Steinberg, H

    2013-08-01

    Paul Julius Möbius (1853-1907), a Leipzig-based author and editor on a vast majority of subjects, has often been acknowledged as a leading 19th-century German neurologist. His impact on the development of knowledge on migraine has likewise been pointed to. This study compares the monograph published by Möbius on the illness in 1894 with contemporary publications and with present day best practice to establish if the author really made an essential contribution to the problem of migraine. As a representative of the central theory Möbius assumed that migraine was caused by aberrations in the brain. At the same time he made it clear that due to very limited diagnostic options this was only a hypothesis. Apart from a genetic factor and these cerebral changes, for Möbius the general state of health was a decisive factor and prevention and change in lifestyle therefore played a crucial role in his therapeutic recommendations. Basically there were only few differences between the views of Möbius and his colleagues, the major dissimilarity being that Möbius postulated a merely suggestive impact but no physical effect of electrotherapy. Although Möbius's monograph on migraine lacks originality, it provides a concise, easy to understand and stylistically impressive overview on the state of knowledge at that time. Therefore, the book can be considered as a benchmark publication of German speaking neurology around 1890 on migraine and it is highly recommended to present day headache and migraine researchers as well as historians of psychiatry and neurology.

  13. Shock, diaschisis and von Monakow

    Directory of Open Access Journals (Sweden)

    Eliasz Engelhardt

    2013-07-01

    Full Text Available The concept of shock apparently emerged in the middle of the 18th century (Whyett as an occurrence observed experimentally after spinal cord transection, and identified as "shock" phenomenon one century later (Hall. The concept was extended (Brown-Séquard and it was suggested that brain lesions caused functional rupture in regions distant from the injured one ("action à distance". The term "diaschisis" (von Monakow, proposed as a new modality of shock, had its concept broadened, underpinned by observations of patients, aiming at distinguishing between symptoms of focal brain lesions and transitory effects they produced, attributable to depression of distant parts of the brain connected to the injured area. Presently, diaschisis is related mainly to cerebrovascular lesions and classified according to the connection fibers involved, as proposed by von Monakow. Depression of metabolism and blood flow in regions anatomically separated, but related by connections with the lesion, allows observing diaschisis with neuroimaging.

  14. Anterior shoulder instability with engaging Hill-Sachs defects: a comparison of arthroscopic Bankart repair with and without posterior capsulodesis.

    Science.gov (United States)

    Cho, Nam Su; Yoo, Jae Hyun; Juh, Hyung Suk; Rhee, Yong Girl

    2016-12-01

    The purpose of this study was to compare the clinical results of isolated arthroscopic Bankart repair and those of arthroscopic Bankart repair with posterior capsulodesis for anterior shoulder instability with engaging Hill-Sachs lesions. Thirty-five shoulders that underwent isolated arthroscopic Bankart repair (Bankart group) and 37 shoulders that underwent arthroscopic Bankart repair with posterior capsulodesis (remplissage group) for anterior shoulder instability with engaging Hill-Sachs lesions were evaluated retrospectively. The mean age at the time of the surgery was 26.1 ± 7.0 years in the Bankart group and 24.8 ± 9.0 years in the remplissage group. At the final follow-up, the Rowe and UCLA scores significantly improved in both the Bankart and remplissage groups (P Bankart group and 8° ± 23° in the remplissage group (P = n.s. and P = 0.044, respectively). There was no decrease in muscle strength in either group. The recurrence rate was 25.7 % in the Bankart group and 5.4 % in the remplissage group (P = 0.022). Arthroscopic Bankart repair with posterior capsulodesis demonstrated good clinical outcomes with a low recurrence rate in the treatment for anterior shoulder instability with an engaging Hill-Sachs lesion. Although a limitation in external rotation was observed, there was no significant limitation of any other motion and no decrease in muscle strength after the remplissage procedure. Posterior capsulodesis alone for remplissage should be considered as a surgical technique that can replace the conventional method. Case-control study, Level III.

  15. Moose von Inselbergen in Benin

    OpenAIRE

    Frahm, Jan-Peter; Porembski, Stefan

    1998-01-01

    Acht Leber- und zehn Laubmoosarten werden von Inselbergen aus Benin angegeben. Fünf der Lebermoose (Acrolejeunea emergens, Riccia atropurpurea, R. congoana, R. discolor, R. moenkemeyeri) und alle Laubmoose (Archidium ohioense, Brachymenium acuminatum, B. exile, Bryum arachnoideum, B. argenteum, Bryum deperssum, Garckea moenkemeyeri, Hyophila involuta, Philonotis mniobryoides und Weissia cf. edentula) werden neu für Benin angegeben. Eight liverworts and ten mosses are reported from inselber...

  16. Tay Sachs disease in Australia: reduced disease incidence despite stable carrier frequency in Australian Jews.

    Science.gov (United States)

    Lew, Raelia M; Proos, Anne L; Burnett, Leslie; Delatycki, Martin; Bankier, Agnes; Fietz, Michael J

    2012-12-10

    To evaluate the outcomes of preconception screening of Jewish Australians for Tay Sachs disease (TSD) carrier status on Jewish TSD-affected births. Epidemiological observational study involving a complete retrospective audit of infantile and intermediate TSD cases diagnosed in Sydney and Melbourne between 1 January 1995 and 31 December 2011 (Royal Children's Hospital Melbourne; Pacific Laboratory Medicine Services, Pathology North, NSW Health Pathology, Sydney; Victorian Clinical Genetics Services, Melbourne; and SA Pathology, Adelaide), and carrier frequency among Jewish high school students attending schools participating in TSD screening programs over the same period. Jewish TSD carrier frequency; and expected versus observed Jewish TSD-affected births. The 2006 Census indicated that most of the total 88,826 Jewish Australians live in Melbourne (46%) and Sydney (40%). The 7,756 Jewish high school students screened for TSD in Sydney and Melbourne during the study period had a carrier frequency of one in 31 (3.26%; 95% CI, 2.89%-3.68%).The estimated expected number of TSD-affected births in Melbourne and Sydney in 1995-2011 was 4.1 for Jewish births and 7.4 for other births (a ratio of Jewish to non-Jewish births of 1:2). The actual number was 12 (four in Sydney and eight in Melbourne), of which two were Jewish (a ratio of Jewish to non-Jewish births of 1:5). This finding of fewer than expected Jewish TSD cases coincided with a period during which screening programs were operating. There have been no Jewish TSD-affected children born to parents who were screened previously. Community education, appreciation of autosomal recessive inheritance and genetic carrier screening before pregnancy are the likely factors in our finding of fewer than expected Jewish babies with TSD. Ongoing outcome monitoring must continue.

  17. Characterization of inducible models of Tay-Sachs and related disease.

    Science.gov (United States)

    Sargeant, Timothy J; Drage, Deborah J; Wang, Susan; Apostolakis, Apostolos A; Cox, Timothy M; Cachón-González, M Begoña

    2012-09-01

    Tay-Sachs and Sandhoff diseases are lethal inborn errors of acid β-N-acetylhexosaminidase activity, characterized by lysosomal storage of GM2 ganglioside and related glycoconjugates in the nervous system. The molecular events that lead to irreversible neuronal injury accompanied by gliosis are unknown; but gene transfer, when undertaken before neurological signs are manifest, effectively rescues the acute neurodegenerative illness in Hexb-/- (Sandhoff) mice that lack β-hexosaminidases A and B. To define determinants of therapeutic efficacy and establish a dynamic experimental platform to systematically investigate cellular pathogenesis of GM2 gangliosidosis, we generated two inducible experimental models. Reversible transgenic expression of β-hexosaminidase directed by two promoters, mouse Hexb and human Synapsin 1 promoters, permitted progression of GM2 gangliosidosis in Sandhoff mice to be modified at pre-defined ages. A single auto-regulatory tetracycline-sensitive expression cassette controlled expression of transgenic Hexb in the brain of Hexb-/- mice and provided long-term rescue from the acute neuronopathic disorder, as well as the accompanying pathological storage of glycoconjugates and gliosis in most parts of the brain. Ultimately, late-onset brainstem and ventral spinal cord pathology occurred and was associated with increased tone in the limbs. Silencing transgenic Hexb expression in five-week-old mice induced stereotypic signs and progression of Sandhoff disease, including tremor, bradykinesia, and hind-limb paralysis. As in germline Hexb-/- mice, these neurodegenerative manifestations advanced rapidly, indicating that the pathogenesis and progression of GM2 gangliosidosis is not influenced by developmental events in the maturing nervous system.

  18. The Late Integrated Sachs-Wolfe Effect and its detectability in galaxy-redshift surveys

    Science.gov (United States)

    Valencia-Díaz, D. R.; Muñoz-Cuartas, J. C.

    2017-07-01

    The late Integrated Sachs-Wolfe (ISW) effect is underwent by the Cosmic Microwave Background (CMB) photons due to the presence of the Large-Scale Structures (LSS) in an expanding Universe and can be measured through the temperature fluctuations of the CMB. In this work we use numerical simulations of structure formation to study the detectability of the ISW effect. Our method comprises the estimation of the density field through a Cloud-In-Cell mass assignment scheme. With the help of Fourier transforms we estimate the time derivative of the gravitational potential field in Fourier and in coordinate's space. Finally, this field is integrated numerically to know the ISW contribution. We study the time derivative of the potential in two approaches. First, an exact solution that makes use of the full velocity field. Second, a linear approximation related with the linear theory for the formation of LSS. We apply the method to three cosmological simulations. First, a box of 400 h-1 Mpc; second, the MultiDark1 simulation; third, the MultiDark-Plank simulation. For all cases we obtain coherent results with the expected in the literature for a ΛCDM cosmology: with the exact solution the temperature fluctuation is near the ± 30 μ K; the linear approximation shows a signal in the expected range of ± 20 μ K. This positive detection on simulations is important in order to know an expectation for the results we should obtain when working with observational data and will have important implications due to the lack of consensus about the detection of the ISW effect in previous works. Acknowledgements: This work was supported by Colciencias and Universidad de Antioquia, Convenio Beca-Pasantía Joven Investigador Convocatoria 645 de 2014.

  19. Identification of two HEXA mutations causing infantile-onset Tay-Sachs disease in the Persian population.

    Science.gov (United States)

    Haghighi, Alireza; Rezazadeh, Jamileh; Shadmehri, Azam Ahmadi; Haghighi, Amirreza; Kornreich, Ruth; Desnick, Robert J

    2011-09-01

    The β-hexosaminidase A (HEXA) mutations in the first reported cases of infantile Tay-Sachs disease in the Persian population were identified in two unrelated consanguineous families. The clinical diagnoses of the affected infants were confirmed by their markedly deficient levels of HEXA activity in plasma or peripheral leukocytes. The specific causative mutation in each family was determined by sequencing the HEXA alleles in both sets of related parents. Two mutations were identified: c.1A>G (p.MIV), which obliterated the initiating methionine in codon 1, and c.1177C>T (p.R393X), which predicted a termination codon or nonsense mutation.

  20. Effect of cyclic, low dose pyrimethamine treatment in patients with Late Onset Tay Sachs: an open label, extended pilot study

    OpenAIRE

    Osher, Etty; Fattal-Valevski, Aviva; Sagie, Liora; Urshanski, Nataly; Sagiv, Nadav; Peleg, Leah; Lerman-Sagie, Tally; Zimran, Ari; Elstein, Deborah; Navon, Ruth; Valevski, Avi; Stern, Naftali

    2015-01-01

    Background Late Onset Tay- Sachs disease (LOTS) is a rare neurodegenerative lysosomal storage disease which results from mutations in the gene encoding the α subunit (HEXA) of β-hexosaminidase enzyme (HexA). At the present time, no effective treatment exists for LOTS and other neurodegenerative diseases involving the central nerve system (CNS). Pyrimethamine (PMT) was previously shown to act as a HexA chaperone in human fibroblasts in vitro carrying some (e.g., αG269S), but not all LOTS-relat...

  1. At least six different mutations in HEXA gene cause Tay-Sachs disease among the Turkish population.

    Science.gov (United States)

    Ozkara, H A; Navon, R

    1998-11-01

    Twenty-five Turkish infants with Tay-Sachs disease (TSD) have been diagnosed in the past 8 years. All are from consanguineous, nonrelated families. The present study deals with the molecular basis of six Turkish TSD patients from five unrelated families in which the parents were first cousins. The five mutations identified in this study were INS-5 G-->A, R393X, R137X, 12-bp deletion in exon 10, and G454D. The first three were reported in earlier studies, two in Turkish TSD infants and one in a French TSD infant.

  2. Pathological alterations typical of human Tay-Sachs disease, in the retina of a deep-sea fish

    Science.gov (United States)

    Fishelson, L.; Delarea, Yacov; Galil, Bella S.

    Micrographs of retinas from the deep-sea fish Cataetyx laticeps revealed visual cells containing membranous whorls in the ellipsoids of the inner segments resulting from stretching and modifications of the mitochondria membranes and their cristae. These pathological structures seem to be homologous to the whorls observed in retinas of human carriers of Tay-Sachs disease. This disease, a genetic disorder, is found in humans and some mammals. Our findings in fish suggest that the gene responsible can be found throughout the vertebrate evolutionary tree, possibly dormant in most taxa.

  3. Group classification of the Sachs equations for a radiating axisymmetric, non-rotating, vacuum space-time

    CERN Document Server

    Ibragimov, N H; Wessels, E J H; Ellis, George F. R.; Ibragimov, Nail H.; Wessels, Ewald J. H.

    2006-01-01

    We carry out a Lie group analysis of the Sachs equations for a time-dependent axisymmetric non-rotating space-time in which the Ricci tensor vanishes. These equations, which are the first two members of the set of Newman-Penrose equations, define the characteristic initial-value problem for the space-time. We find a particular form for the initial data such that these equations admit a Lie symmetry, and so defines a geometrically special class of such spacetimes. These should additionally be of particular physical interest because of this special geometric feature.

  4. Didaktische Konzeption von Serious Games: Zur Verknüpfung von Spiel- und Lernangeboten

    Directory of Open Access Journals (Sweden)

    Michael Kerres

    2009-08-01

    Full Text Available Serious Games versuchen Spielen mit Lernen zu verbinden. Der Beitrag problematisiert die Machbarkeit einer solchen Verknüpfung in digitalen Welten und diskutiert verschiedene didaktische Konzepte einer Nutzbarmachung digitaler Spiele für das Lernen und Lehren. Ausgehend von einer Analyse des Erlernens von Spielen werden drei didaktische Konzepte von Serious Games im Hinblick auf ihre didaktischen Potenziale untersucht: (1 der unmittelbare Transfer von Wissen, das im Spiel erworben wird (keine zusätzliche Didaktisierung, (2 Didaktisierung durch Einbettung des Spiels in einer Lernsituation oder (3 Didaktisierung durch Einbettung von Lernaufgaben in ein Spiel. Ergebnisse zur Nutzung von Spielen, bei denen Lernaufgaben in eine Spielwelt eingebettet sind, zeigen, dass Personen die Aufnahme von Wissen in einem expliziten Lernmodus eher zu reduzieren versuchen, um möglichst zügig wieder in den Spielmodus zu wechseln. Diskutiert werden die Konsequenzen dieser Problematik für die didaktische Konzeption von Serious Games.

  5. Dr. von Braun Briefing Walt Disney

    Science.gov (United States)

    1965-01-01

    Dr. von Braun began his association with Walt Disney in the 1950s when the rocket scientist appeared in three Disney television productions related to the exploration of space. Years later, Dr. von Braun invited Disney and his associates to tour the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. This photograph is dated April 13, 1965. From left are R.J. Schwinghamer from the MSFC, Disney, B.J. Bernight, and Dr. von Braun.

  6. Reflexionseigenschaften von Windenergieanlagen im Funkfeld von Funknavigations- und Radarsystemen

    Science.gov (United States)

    Sandmann, S.; Divanbeigi, S.; Garbe, H.

    2015-11-01

    Die hier behandelte Untersuchung befasst sich mit den Störungen des elektrischen Feldes einer Doppler Very High Frequency Omnidirectional Radio Range Navigationsanlage (DVOR) in der Gegenwart von Windenergieanlagen (WEA). Hierfür wird die Feldstärke auf 25 konzentrischen Kreisbahnen, sog. Orbit Flights verschiedener Höhen und mit verschiedenen Radien rund um die DVOR-Anlage numerisch simuliert. Insbesondere werden die Einflüsse diverser Parameter der WEA wie deren Anzahl, Position, Rotorwinkel, Turmhöhe und Rotordurchmesser auf die Feldverteilung herausgestellt, sowie die Anwendbarkeit der Simulationsmethode Physical Optics (PO) durch Vergleich der Simulationsergebnisse mit denen der Multi Level Fast Multipol Method (MLFMM) untersucht.

  7. Crystal Structure of Human [Beta]-Hexosaminidase B: Understanding the Molecular Basis of Sandhoff and Tay-Sachs Disease

    Energy Technology Data Exchange (ETDEWEB)

    Mark, Brian L.; Mahuran, Don J.; Cherney, Maia M.; Zhao, Dalian; Knapp, Spencer; James, Michael N.G.

    2010-12-01

    In humans, two major {beta}-hexosaminidase isoenzymes exist: Hex A and Hex B. Hex A is a heterodimer of subunits {alpha} and {beta} (60% identity), whereas Hex B is a homodimer of {beta}-subunits. Interest in human {beta}-hexosaminidase stems from its association with Tay-Sachs and Sandhoff disease; these are prototypical lysosomal storage disorders resulting from the abnormal accumulation of G{sub M2}-ganglioside (G{sub M2}). Hex A degrades G{sub M2} by removing a terminal N-acetyl-D-galactosamine ({beta}-GalNAc) residue, and this activity requires the G{sub M2}-activator, a protein which solubilizes the ganglioside for presentation to Hex A. We present here the crystal structure of human Hex B, alone (2.4 {angstrom}) and in complex with the mechanistic inhibitors GalNAc-isofagomine (2.2 {angstrom}) or NAG-thiazoline (2.5 {angstrom}). From these, and the known X-ray structure of the G{sub M2}-activator, we have modeled Hex A in complex with the activator and ganglioside. Together, our crystallographic and modeling data demonstrate how {alpha} and {beta}-subunits dimerize to form either Hex A or Hex B, how these isoenzymes hydrolyze diverse substrates, and how many documented point mutations cause Sandhoff disease ({beta}-subunit mutations) and Tay-Sachs disease ({alpha}-subunit mutations).

  8. Planung von CLIL-Unterricht

    Directory of Open Access Journals (Sweden)

    Josef Leisen

    2015-10-01

    Full Text Available Der Beitrag formuliert die Sprachlernbedingungen und die Leitlinien des Sprachlernens im Fach und nennt Merkmale des guten integrierten Fach- und Sprachlehrens. Ausgehend von den Sprachproblemen, die sich im CLIL-Unterricht auftun, wird der sprachsensible CLIL-Unterricht definiert, und es werden Anregungen zur Gestaltung gegeben. Sprachliche Standardsituationen umfassen die kommunikativen Situationen im CLIL-Unterricht, die beim fachlichen Lernen auftreten und von der CLIL-Lehrkraft professionell bewältigt werden müssen. Im Beitrag wird ein Lehr-Lern-Modell ausführlich beschrieben und erläutert. Die Steuerungen von Sprachlernprozessen im CLIL durch Aufgabenstellungen, Methoden-Werkzeuge, Moderation und Diagnose/Rückmeldung werden ausführlich beschrieben. Die Planung einer Lernlinie in sechs Schritten wird dargestellt und erläutert. Planungsraster für CLIL-Lernlinien schließen den Beitrag ab. The article sets out the conditions for language learning in general as well as guiding principles of language learning in the subject and puts forward criteria for successfully integrated content and language learning. Based on typical language problems arising in CLIL-classrooms, the language-sensitive CLIL-classroom is defined and organisational suggestions are given. Linguistic standard situations comprise the communicative situations in the CLIL-classroom which are encountered in subject-related learning and have to be professionally mastered by the CLIL-teacher. The article extensively describes and explains a model of teaching and learning that can be used for the CLIL-classroom. It gives detailed information on managing language learning processes in CLIL by means of tasks, resources and methods as well as discourse facilitation, evaluation and feedback. In addition, a six-step lesson unit is outlined and explained. The article concludes by giving a planning matrix for CLIL lesson units.

  9. The SDSS-III Baryonic Oscillation Spectroscopic Survey: constraints on the integrated Sachs-Wolfe effect

    Science.gov (United States)

    Hernández-Monteagudo, Carlos; Ross, Ashley J.; Cuesta, Antonio; Génova-Santos, Ricardo; Xia, Jun-Qing; Prada, Francisco; Rossi, Graziano; Neyrinck, Mark; Viel, Matteo; Rubiño-Martin, Jose-Alberto; Scóccola, Claudia G.; Zhao, Gongbo; Schneider, Donald P.; Brownstein, Joel R.; Thomas, Daniel; Brinkmann, Jonathan V.

    2014-02-01

    In the context of the study of the integrated Sachs-Wolfe (ISW) effect, we construct a template of the projected density distribution up to redshift z ≃ 0.7 by using the luminous galaxies (LGs) from the Sloan Digital Sky Survey (SDSS) Data Release 8 (DR8). We use a photometric redshift catalogue trained with more than a hundred thousand galaxies from the Baryon Oscillation Spectroscopic Survey (BOSS) in the SDSS DR8 imaging area covering nearly one-quarter of the sky. We consider two different LG samples whose selection matches that of SDSS-III/BOSS: the low-redshift sample (LOWZ, z ∈ [0.15, 0.5]) and the constant mass sample (CMASS, z ∈ [0.4, 0.7]). When building the galaxy angular density templates we use the information from star density, survey footprint, seeing conditions, sky emission, dust extinction and airmass to explore the impact of these artefacts on each of the two LG samples. In agreement with previous studies, we find that the CMASS sample is particularly sensitive to Galactic stars, which dominate the contribution to the auto-angular power spectrum below ℓ = 7. Other potential systematics affect mostly the very low multipole range (ℓ ∈ [2, 7]), but leave fluctuations on smaller scales practically unchanged. The resulting angular power spectra in the multipole range ℓ ∈ [2, 100] for the LOWZ, CMASS and LOWZ+CMASS samples are compatible with linear Λ cold dark matter (ΛCDM) expectations and constant bias values of b = 1.98 ± 0.11, 2.08 ± 0.14 and 1.88 ± 0.11, respectively, with no traces of non-Gaussianity signatures, i.e. f_NL^local=59± 75 at 95 per cent confidence level for the full LOWZ+CMASS sample in the multipole range ℓ ∈ [4, 100]. After cross-correlating Wilkinson Microwave Anisotropy Probe 9-year data with the LOWZ+CMASS LG projected density field, the ISW signal is detected at the level of 1.62-1.69σ. While this result is in close agreement with theoretical expectations and predictions from realistic Monte Carlo

  10. Walt Disney and Dr. Wernher von Braun

    Science.gov (United States)

    1954-01-01

    Dr. Werhner von Braun, then Chief, Guided Missile Development Operation Division at Army Ballistic Missile Agency (ABMA) in Redstone Arsenal, Alabama, was visited by Walt Disney in 1954. In the 1950's, von Braun worked with Disney Studio as a technical director, making three films about space exploration for television. A model of the V-2 rocket is in background.

  11. Von Neumann Was Not a Quantum Bayesian

    CERN Document Server

    Stacey, Blake C

    2014-01-01

    Wikipedia has claimed for over two years now that John von Neumann was the "first quantum Bayesian." In context, this reads as stating that von Neumann inaugurated QBism, the approach to quantum theory promoted by Fuchs, Mermin and Schack. This essay explores how such a claim is, historically speaking, unsupported.

  12. Kultuuriakadeemias saab kaeda Von Krahli ime tabamist

    Index Scriptorium Estoniae

    2006-01-01

    Marianne Kõrver, Jaak Kilmi, Andres Maimik, Marko Raat, Rainer Sarnet ja Arbo Tammiksaar tegid Eduard Vilde näidendist "Tabamata ime" kuus lühimängufilmi Von Krahli teatris ettekandmiseks. 25. mail tuleb Von Krahli Teater Viljandisse ja näitab teatrifilmi Kultuuriakadeemias

  13. Mixing subalgebras of finite von Neumann algebras

    CERN Document Server

    Cameron, Jan; Mukherjee, Kunal

    2010-01-01

    Jolissaint and Stalder introduced the definitions of mixing and weak mixing for von Neumann subalgebras of finite von Neumann algebras. In this paper, we study various algebraic and analytical properties of mixing and weakly mixing von Neumann subalgebras. We prove some basic results about mixing inclusions of von Neumann algebras and establish a connection between mixing properties and normalizers of von Neumann subalgebras. The special case of mixing subalgebras arising from inclusions of group von Neumann algebras finds applications to ergodic theory. For a finite von Neumann algebra $M$ and von Neumann subalgebras $A$, $B$ of $M$, we introduce a notion of weak mixing of $B\\subseteq M$ relative to $A$. If $B$ is abelian and $A\\subset B$, we show that weak mixing of $B \\subset M$ relative to $A$ is equivalent to the following property: if $x\\in M$ and $xAx^*\\subset B$ then $x\\in B$. In the general case, we show that weak mixing of $B\\subset M$ relative to $A$ is equivalent to the following property: if $x\\i...

  14. Ludwig von Mises: An Annotated Bibliography.

    Science.gov (United States)

    Gordon, David

    A 117-item annotated bibliography of books, articles, essays, lectures, and reviews by economist Ludwig von Mises is presented. The bibliography is arranged chronologicaly, and is followed by an alphabetical listing of the citations, excluding books. An index and information on the Ludwig von Mises Institute at Auburn University (Alabama) are…

  15. Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system.

    Science.gov (United States)

    Miklyaeva, Elena I; Dong, Weijia; Bureau, Alexandre; Fattahie, Roya; Xu, Yongqin; Su, Meng; Fick, Gordon H; Huang, Jing-Qi; Igdoura, Suleiman; Hanai, Nobuo; Gravel, Roy A

    2004-03-19

    Tay-Sachs disease is an autosomal recessive neurodegenerative disease resulting from a block in the hydrolysis of GM2 ganglioside, an intermediate in ganglioside catabolism. The mouse model of Tay-Sachs disease (Hexa -/-) has been described as behaviorally indistinguishable from wild type until at least 1 year of age due to a sialidase-mediated bypass of the metabolic defect that reduces the rate of GM2 ganglioside accumulation. In this study, we have followed our mouse model to over 2 years of age and have documented a significant disease phenotype that is reminiscent of the late onset, chronic form of human Tay-Sachs disease. Onset occurs at 11-12 months of age and progresses slowly, in parallel with increasing storage of GM2 ganglioside. The disease is characterized by hind limb spasticity, weight loss, tremors, abnormal posture with lordosis, possible visual impairment, and, late in the disease, muscle weakness, clasping of the limbs, and myoclonic twitches of the head. Immunodetection of GM2 ganglioside showed that storage varies widely in different regions, but is most intense in pyriform cortex, hippocampus (CA3 field, subiculum), amygdala, hypothalamus (paraventricular supraoptic, ventromedial and arcuate nuclei, and mammilary body), and the somatosensory cortex (layer V) in 1- to 2-year-old mutant mice. We suggest that the Tay-Sachs mouse model is a phenotypically valid model of disease and may provide for a reliable indicator of the impact of therapeutic strategies, in particular geared to the late onset, chronic form of human Tay-Sachs disease.

  16. Impact of gene patents and licensing practices on access to genetic testing and carrier screening for Tay-Sachs and Canavan disease.

    Science.gov (United States)

    Colaianni, Alessandra; Chandrasekharan, Subhashini; Cook-Deegan, Robert

    2010-04-01

    Genetic testing for Tay-Sachs and Canavan disease is particularly important for Ashkenazi Jews, because both conditions are more frequent in that population. This comparative case study was possible because of different patenting and licensing practices. The role of DNA testing differs between Tay-Sachs and Canavan diseases. The first-line screening test for Tay-Sachs remains an enzyme activity test rather than genotyping. Genotyping is used for preimplantation diagnosis and confirmatory testing. In contrast, DNA-based testing is the basis for Canavan screening and diagnosis. The HEXA gene for Tay-Sachs was cloned at the National Institutes of Health, and the gene was patented but has not been licensed. The ASPA gene for Canavan disease was cloned and patented by Miami Children's Hospital. Miami Children's Hospital did not inform family members and patient groups that had contributed to the gene discovery that it was applying for a patent, and pursued restrictive licensing practices when a patent issued in 1997. This led to intense controversy, litigation, and a sealed, nonpublic 2003 settlement that apparently allowed for nonexclusive licensing. A survey of laboratories revealed a possible price premium for ASPA testing, with per-unit costs higher than for other genetic tests in the Secretary's Advisory Committee on Genetics, Health, and Society case studies. The main conclusion from comparing genetic testing for Tay-Sachs and Canavan diseases, however, is that patenting and licensing conducted without communication with patients and advocates cause mistrust and can lead to controversy and litigation, a negative model to contrast with the positive model of patenting and licensing for genetic testing of cystic fibrosis.

  17. Pflege – eine Sache der ganzen Familie Care—An Issue for the Whole Family

    Directory of Open Access Journals (Sweden)

    Nicole Maly-Lukas

    2005-07-01

    Full Text Available Derzeit sind in der Bundesrepublik Deutschland ca. 2 Millionen Menschen pflegebedürftig. Etwa 1,4 Millionen werden im häuslichen Bereich – in der Regel von Familienmitgliedern gepflegt – z. T. mit professioneller Unterstützung. Die Familie ist also weiterhin „der größte Pflegedienst der Nation“. Und es sind hauptsächlich die Frauen, die sich für die Pflege von Familienmitgliedern verantwortlich fühlen. Gröning et al. möchten sich in ihrem Buch In guten wie in schlechten Tagen aber nicht auf die Belastungen der pflegenden Frauen beschränken. Sie stellen die Generationen- und Geschlechterbeziehungen, die einen großen Einfluss auf die familiäre Pflegebeziehung haben, in den Vordergrund. In dem Buch Pflegegeschichten kommen rund 40 pflegende Angehörige selbst zu Wort, indem sie ‚ihre‘ persönliche „Pflegegeschichte“ erzählen.At this time in the Federal Republic of Germany around two million people are in need of care. Around 1.4 million of these are cared for at home—for the most part by family members—partly with professional support. The family thus continues to be “the largest nursing service in the nation.” And it is mostly women who feel responsible for the care of family members. The editors do not wish to limit themselves only to the pressures on the care-giving women in their book In guten wie in schlechten Tagen (In Sickness and in Health. They place in the foreground generational and gendered relationships that have a great influence on familial nursing relationships. In the book Pflegegeschichten (Nursing Stories around 40 care-giving relatives speak for themselves by telling their “own” personal “nursing stories.”

  18. Jacob Stael von Holstein ja palladionism eesti arhitektuuris / Ants Hein

    Index Scriptorium Estoniae

    Hein, Ants, 1952-

    2005-01-01

    Sõjaväeinsenerist ja arhitektist Jacob Stael von Holsteinist (1628, Pärnu-1679), tema kavandatud hoonetest ja rollist 17. sajandi II poole arhitektuuris. Fabian von Ferseni Toompeal Lossiplatsil asunud elamust (lammutati 1894) ja Maardu mõisahoonest, Hans von Ferseni Mäo mõisahoonest Järvamaal, Otto Wilhelm von Ferseni majast Toompeal, Axel von Roseni majast Tallinnas Pikk t. 28 (1670-74), Otto Reinhold von Taube majast Tartus (hävinud), J. S. von Holsteini enda hoonetest: majast Tallinnas Toompea 1, Anija mõisahoonest, elamust Riias jm. Bibliograafia lk. 452

  19. Jacob Stael von Holstein ja palladionism eesti arhitektuuris / Ants Hein

    Index Scriptorium Estoniae

    Hein, Ants, 1952-

    2005-01-01

    Sõjaväeinsenerist ja arhitektist Jacob Stael von Holsteinist (1628, Pärnu-1679), tema kavandatud hoonetest ja rollist 17. sajandi II poole arhitektuuris. Fabian von Ferseni Toompeal Lossiplatsil asunud elamust (lammutati 1894) ja Maardu mõisahoonest, Hans von Ferseni Mäo mõisahoonest Järvamaal, Otto Wilhelm von Ferseni majast Toompeal, Axel von Roseni majast Tallinnas Pikk t. 28 (1670-74), Otto Reinhold von Taube majast Tartus (hävinud), J. S. von Holsteini enda hoonetest: majast Tallinnas Toompea 1, Anija mõisahoonest, elamust Riias jm. Bibliograafia lk. 452

  20. A detection of the integrated Sachs-Wolfe imprint of cosmic superstructures using a matched-filter approach

    CERN Document Server

    Nadathur, Seshadri

    2016-01-01

    We present a new method for detection of the integrated Sachs-Wolfe (ISW) imprints of cosmic superstructures on the cosmic microwave background, based on a matched filtering approach. The expected signal-to-noise ratio for this method is comparable to that obtained from the full cross-correlation, and unlike other stacked filtering techniques it is not subject to an a posteriori bias. We apply this method to Planck CMB data using voids and superclusters identified in the CMASS galaxy data from the Sloan Digital Sky Survey Data Release 12, and measure the ISW amplitude to be $A_\\mathrm{ISW}=1.64\\pm0.53$ relative to the $\\Lambda$CDM expectation, corresponding to a $3.1\\sigma$ detection. In contrast to some previous measurements of the ISW effect of superstructures, our result is in agreement with the $\\Lambda$CDM model.

  1. Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient.

    Science.gov (United States)

    Liu, Zhong; Zhao, Rui

    2016-09-01

    Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD). The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers. This TSD patient-derived hiPSC line may serve as a valuable in vitro tool for disease modeling and drug test.

  2. Generation of HEXA-deficient hiPSCs from fibroblasts of a Tay-Sachs disease patient

    Directory of Open Access Journals (Sweden)

    Zhong Liu

    2016-09-01

    Full Text Available Human iPSC line TSD-01-hiPSC was generated from fibroblasts of a patient with infantile Tay-Sachs disease (TSD. The patient is compound heterozygous at the HEXA gene by carrying a 1278insTATC allele and an IVS12+1G>C allele. STEMCCA lentivirus, which expresses OCT4, SOX2, KLF4, and c-MYC from a polycistronic transcript, were used for reprogramming. TSD-01-hiPSC express pluripotency markers such as OCT4, SOX2, NANOG, Tra-1-60, and alkaline phosphatase, and can differentiate into tissues from all the three embryonic germ layers. This TSD patient-derived hiPSC line may serve as a valuable in vitro tool for disease modeling and drug test.

  3. [Von Hippel-Lindau syndrome].

    Science.gov (United States)

    Reich, H; Hollwich, F

    1984-06-01

    The von Hippel-Lindau syndrome is an autosomal dominant condition that comprises, apart from angiomas of the retina, the cerebellum, the spinal cord, and the cerebrum, also cystic and blastomatous dysplasias resulting from maldevelopment, namely cystic kidney and pancreas, hypernephroma, and pheochromocytoma. Early observers of the syndrome were the English neurologist John Hughlings Jackson (1872) and the German ophthalmologist Hugo Magnus (1874). The typical association of angiomas of the retina with the cerebellum was first described in 1905 by the Prague ophthalmologist Wilhelm Czermak, long before Lindau (1926). The fact that hypernephromas and pheochromocytomas may form parts of it characterizes the syndrome as a polyneoplastic hereditary disease and the sufferers as members of families at risk. Since the ophthalmologist is often the first to recognize this disease by direct inspection of the fundi, he is responsible for ensuring proper medical care for the affected person and his or her entire family.

  4. The Digital Von Fahrenheid Pyramid

    Science.gov (United States)

    Bura, M.; Janowski, J.; Wężyk, P.; Zięba, K.

    2017-08-01

    3D Scanners Lab from Digital Humanities Laboratory at the University of Warsaw initiated the scientific project, the purpose of which was to call attention to systematically penetrated and devastated pyramid-shaped tomb from the XVIII/XIX century, of family von Fahrenheid in Rapa in Banie Mazurskie commune (NE Poland). By conducting a series of non-invasive studies, such as 3D inventory using terrestrial laser scanning (TLS), thermal imaging, georadar measurements (around and inside the tomb) and anthropological research of mummified remains as well - the complete dataset was collected. Through the integration of terrestrial (TLS) and airborne laser scanning (ALS) authors managed to analyse the surroundings of Fahrenheid pyriamid and influence of some objects (like trees) on the condition and visibility of the Pyramids in the landscape.

  5. Neues über das Tertiär von Java und die mesozoischen Schichten von West-Borneo

    NARCIS (Netherlands)

    Martin, K.

    1888-01-01

    Die Monographie, welche unter dem Titel Die Fossilien von Java herausgegeben wird ¹), ist so weit fortgeschritten, dass sich aus den in ihr beschriebenen Gastropoden bereits eine Anzahl von Schlussfolgerungen ableiten lässt, welche für die in Bearbeitung begriffene, geologische Karte von Java von

  6. Neues über das Tertiär von Java und die mesozoischen Schichten von West-Borneo

    NARCIS (Netherlands)

    Martin, K.

    1888-01-01

    Die Monographie, welche unter dem Titel Die Fossilien von Java herausgegeben wird ¹), ist so weit fortgeschritten, dass sich aus den in ihr beschriebenen Gastropoden bereits eine Anzahl von Schlussfolgerungen ableiten lässt, welche für die in Bearbeitung begriffene, geologische Karte von Java von Be

  7. Large Hill-Sachs Lesion: a Comparative Study of Patients Treated with Arthroscopic Bankart Repair with or without Remplissage.

    Science.gov (United States)

    Garcia, Grant H; Park, Min Jung; Zhang, Clare; Kelly, John D; Huffman, G Russell

    2015-07-01

    There is little comparative long-term clinical data comparing Bankart repair alone to the addition of remplissage. Our purpose was to compare results of patients with significant humeral head lesions and who underwent either isolated arthroscopic Bankart repair or remplissage. This is a retrospective cohort study of 14 isolated arthroscopic Bankart and 10 remplissage repairs all with large engaging Hill-Sachs (HS) lesions. Average follow-up was 40.72 months (26.3-51.1) in the Bankart group and 31.55 months (24.1-39.9) in the remplissage group. Surgical failure was defined as a dislocation or subluxation. Groups were matched on handedness, age within 3 years, and HS lesion size. Glenoid bone loss and HS size were measured on MRI. Additionally, WOSI and DASH scores were obtained. The average age at surgery was 26.0 years (17.8-41.1) of the isolated Bankart patient and 24.4 years (16.4-38.3) in the remplissage group. The average HS lesion volume was 310.22 mm(3) in the Bankart group and 283.79 mm(3) in the remplissage group. The failure rate for the Bankart group was 8 out of 14 patients (57.14%). For the remplissage group, the failure rate was 2 out of 10 patients (20.0%). Average WOSI scores were 73.72 in the Bankart group and 79.54 in the remplissage group. For DASH scores, the average Disability/Symptoms Scores were 16.23 for the Bankart group and 12.05 for the remplissage patients. In comparison to isolated Bankart repair, remplissage was a superior option for recurrent instability patients with large Hill-Sachs lesions as seen by diminished failure rates and improved outcome scores.

  8. GM2-Gangliosidosis (Sandhoff and Tay Sachs disease: Diagnosis and Neuroimaging Findings (An Iranian Pediatric Case Series

    Directory of Open Access Journals (Sweden)

    Parvaneh KARIMZADEH

    2014-07-01

    Full Text Available How to Cite This Article: Karimzadeh P, Jafari N, Nejad Biglari H, Jabbeh Dari S, Ahmad Abadi F, Alaee MR, Nemati H, Saket S,Tonekaboni SH, Taghdiri MM, Ghofrani M. GM2-Gangliosidosis (Sandhoff and Tay Sachs disease: Diagnosis and Neuroimaging Findings (An Iranian Pediatric Case Series Iran J Child Neurol. 2014 Summer;8(3: 55-60. AbstractObjectiveGM2-Gangliosidosis disease is a rare autosomal recessive genetic disorder that includes two disorders (Tay–Sachs and Sandhoff disease.These disorders cause a progressive deterioration of nerve cells and inherited deficiency in creatinghexosaminidases A, B, and AB.Materials & MethodsPatients who were diagnosed withGM2-Gangliosidosis in the Neurology Department of Mofid Children’s Hospital in Tehran, Iran from October 2009 to February 2014were included in our study. The disorder was confirmed by neurometabolic and enzyme level detection of hexosaminidases A, B, and ABin reference to Wagnester Laboratory in Germany. We assessed age, gender, past medical history, developmental status, clinical manifestations, and neuroimaging findings of 9 patients with Sandhoff disease and 9 with Tay Sachs disease.Results83% of our patients were the offspring of consanguineous marriages. All of them had a developmental disorder as a chief complaint.38%of patients had a history of developmental delay or regression and 22% hadseizures. The patients with Sandhoff and Tay Sachs disease were followed for approximately 5 years and the follow-up showed all patients were bedridden or had expired due to refractory seizures, pneumonia aspiration, or swallowingdisorders.Neuro-imaging findings included bilateral thalamic involvement, brain atrophy, and hypo myelination in near half of our patients (48%. ConclusionAccording to the results of this study, we suggest that cherry-red spots, hyperacusis, refractory seizures, and relative parents in children with developmental delay and/or regression should be considered

  9. Einfluss der Koordination von Spurenelementen in Silikatschmelzen auf Verteilungsprozesse

    OpenAIRE

    Sebastian Simon

    2016-01-01

    Das Wissen um die lokale Struktur von Seltenen Erden Elementen (SEE) in silikatischen und aluminosilikatischen Schmelzen ist von fundamentalem Interesse für die Geochemie der magmatischen Prozesse, speziell wenn es um ein umfassendes Verständnis der Verteilungsprozesse von SEE in magmatischen Systemen geht. Es ist allgemein akzeptiert, dass die SEE-Verteilungsprozesse von Temperatur, Druck, Sauerstofffugazität (im Fall von polyvalenten Kationen) und der Kristallchemie kontrolliert werden. All...

  10. Charakterisierung von Radiolyseprodukten in gammabestrahlten Polyamiden Thermodesorption-Gaschromatographie Massenspekroskopie

    OpenAIRE

    Selmi, Hany

    2008-01-01

    Der Verbrauch von Polyamiden in allen technischen Bereichen, darunter im Bereich der Verpackung von Lebensmitteln sowie im Bereich der Herstellung von medizinischen Artikeln und Geräten steigt stetig an. Dies beruht auf ihren Eigenschaften wie hohe Festigkeit, ausgezeichnete Thermoformbarkeit, hohe Wärmeformbeständigkeit, Sterilisierbarkeit und sehr gute Barriereeigenschaften gegen Gase, insbesondere gegenüber Sauerstoff und Aromen. Die Anwendung von Gammastrahlen zur Sterilisation von Verpac...

  11. Von Laue's theorem and its applications

    CERN Document Server

    Wang, Changbiao

    2012-01-01

    Von Laue's theorem is strictly proved in detail to clarify confusions in textbook and literature. This theorem is used to analyze the classical electron and the static electric field confined in a finite region of space.

  12. Arbeit von Frauen in Zeiten der Globalisierung

    NARCIS (Netherlands)

    D. Grunow

    2010-01-01

    Hohe Erwerbsquote, Dienstleistungsberufe und Minijobs: Die weibliche Erwerbstätigkeit hat sich in den letzten Jahrzehnten in Deutschland stark verändert. Wie hängen die Prozesse zusammen mit der Globalisierung von Wirtschaft und Arbeit?

  13. Titanisierung von Implantatoberflächen

    Science.gov (United States)

    Zimmermann, Hanngörg; Heinlein, Markus; Guldner, Norbert W.

    Titan gilt seit Jahrzehnten als einer der wichtigsten Implantatwerkstoffe in der Medizin. Neben den guten mechanischen Eigenschaften (Leichtigkeit, hohe Festigkeit etc.), besitzen Titanimplantate vor allem eine hervorragende Körperverträglichkeit, so dass die Implantate optimal in den humanen Organismus integriert werden [1]. Ist jedoch aufgrund der Anforderungen an das Implantat eine hohe Flexibilität und/ oder Elastizität gefragt, so scheidet der Werkstoff Titan aufgrund seiner spröden und unflexiblen Materialeigenschaften aus. Die Folge ist der Einsatz von Implantatmaterialien, sowohl künstlichen als auch biologischen Ursprungs, welche nicht selten eine unzureichende Biokompatibilität aufweisen und somit zu Fremdköper- und immunologischen Reaktionen und Einkapselung des Implantates führen können. Die Erhöhung der Körperverträglichkeit, eine Adaption an das biologische Umfeld und eine hohe Biokompatibilität sind demzufolge die wichtigsten Eigenschaften bei der bedarfsgerechten Herstellung von Implantaten und Implantatoberflächen. Zur Gestaltung von innovativen, biokompatiblen Oberflächen stehen unterschiedliche technische Lösungsansätze zur Verfügung. Zum einen besteht die Möglichkeit, geeignete Oberflächeneigenschaften aus dem Grundmaterial selbst zu optimieren. Dies geschieht unter anderem durch Modifikation der Werkstoffoberflächen in Form von Texturierungen und Oberflächenrauhigkeiten. Zum anderen können die Oberflächeneigenschaften unabhängig von denen des Trägermaterials gestaltet werden. Durch Funktionalisierung der Oberflächen mit geeigneten Beschichtungen oder der Zugabe von Medikamenten (Drug Eluting) werden die Kunststoffimplantate dahingehend verändert, dass eine Steigerung der Körperakzeptanz erreicht wird. Die Titanbeschichtung von Implantatoberflächen kombiniert die positiven Materialeigenschaften von Titan und Polymer.

  14. Beschichtung von Kohlenstofffasern durch Chemische Gasphasenabscheidung (CVD)

    OpenAIRE

    Schmidt, Stephan

    2005-01-01

    Der Einsatz faserverstärkter Verbundwerkstoffe mit metallischer und keramischer Matrix bietet den Vorteil von Kombination und optimaler Ausnutzung verschiedenster Werkstoffeigenschaften. Die Verwendung einer durch Kohlenstofffasern verstärkten keramischen Matrix erlangte dabei in der kürzeren Vergangenheit vermehrtes Interesse. Grundlegend für den erfolgreichen Einsatz von Faserverbundwerkstoffen ist dabei ein optimiertes Faser-Matrix-Interface, also eine "optimale" Haftung der Fasern innerha...

  15. Studien zur didaktischen Nutzung von Concept Maps

    OpenAIRE

    Jüngst, Karl Ludwig

    1995-01-01

    In einer ersten Studie wurde geprüft, ob elaborierendes Durcharbeiten von Concept Maps lerneffektiver ist als elaborierendes Durcharbeiten von analogen Texten. Es wurden 13 Exemplare in unterschiedlichen Schulfächern im Sekundarschulwesen durchgeführt. Die Versuchs- Klassen arbeiten Concept Maps zu einem bestimmten Begriff durch, die Kontrollklassen analoge Texte. Die Behaltensleistung auf einfacherem Anforderungsniveau war in den Klassen mit Concept Maps besser als in den Klassen mit Texten....

  16. Hullud päevad von Krahlis

    Index Scriptorium Estoniae

    2006-01-01

    Von Krahli Teatris mängitakse neil päevi neli korda Peeter Jalaka lavastuses Tõnu Kõrvitsa kammeroopereid "Tuliaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libreto autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  17. 50th birthday of Christian von Ferber

    Directory of Open Access Journals (Sweden)

    2011-06-01

    Full Text Available On May 15, 2011 Christian von Ferber - member of the Editorial Board of "Condensed Matter Physics" and renowned expert in the fields of soft matter physics and complex systems - celebrated his 50th birthday. The Editorial board of CMP, colleagues and friends warmy congratulate Christian von Ferber and wish him and his family continuing good health and to enjoy many adventures and discoveries in his future scientific travels!

  18. Charakterisierung von Wechselwirkungsprozessen in sensitiven Schichten

    OpenAIRE

    Rathgeb, Frank

    1999-01-01

    Die vorliegende Arbeit soll verschiedene Strategien aufzeigen, um eine selektive Anreicherung gasförmiger Analytmoleküle in sensitiven Schichten zu erzielen. Im Mittelpunkt des Interesses lagen hierbei pH-responsive Polymere, mikroporöse Schichten und Cyclohexapeptide. Mit den pH-responsiven Polymeren konnte eine selektive und sensitive Detektion von Ammoniak mit Nachweisgrenzen von 150 ppb erreicht werden. Die Stabilität der sensitiven Schicht konnte im Vergleich zu farbstoffdotie...

  19. Hullud päevad von Krahlis

    Index Scriptorium Estoniae

    2006-01-01

    Von Krahli Teatris mängitakse neil päevi neli korda Peeter Jalaka lavastuses Tõnu Kõrvitsa kammeroopereid "Tuliaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libreto autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  20. [Joint reconstruction with autologous bone cylinder and locked intramedullary nail: proximal humeral shaft fracture with ipsilateral reverse Hill-Sachs lesion].

    Science.gov (United States)

    Osterhoff, G; Hepp, P; Engel, T; Josten, C

    2009-03-01

    The case of a 51-year-old patient is presented, with a humeral shaft fracture in combination with an ipsilateral reverse Hill-Sachs lesion, presumably after posterior shoulder dislocation as a result of an electrical accident followed by a fall from a ladder. After corresponding diagnostics, osteosynthesis of the shaft fracture was performed with a locked antegrade intramedullary nail. Simultaneously the reverse Hill-Sachs lesion was elevated und supplemented with the bone core that accrues during drilling of the nail entrance. In the follow-up period good fragment alignment, persistent joint stability and freedom of pain could be observed. On the basis of this case and the current literature the injury mechanism and potential therapy alternatives are discussed.

  1. Mechanical efficiency during gait of adults with transtibial amputation: a pilot study comparing the SACH, Seattle, and Golden-Ankle prosthetic feet.

    Science.gov (United States)

    Prince, F; Winter, D A; Sjonnensen, G; Powell, C; Wheeldon, R K

    1998-06-01

    As more and more prosthetic feet become commercially available, the selection of the appropriate device is a more difficult task for clinical team members. To date, ranking prosthetic feet based on biomechanical parameters has been done using the spring efficiency. The current analytical technique for calculating spring efficiency has two flaws: first, prosthetic feet with a bendable flexible keel are analyzed the same way as those with an articulated ankle and a rigid foot, and second, there is no accounting for the energy losses in the viscoelastic cosmetic material surrounding the keel. This paper develops a rigorous technique to calculate the net energy stored or dissipated and then recovered during the stance phase of gait. Five adults with transtibial amputation were tested with three different prosthetic feet: SACH, Seattle, and Golden-Ankle. The subjects walked at self-selected cadence and stepped on a force plate while two-dimensional segmental kinematic and kinetic data were collected. The results showed that the Golden-Ankle stored or dissipated and then recovered significantly more energy than either the SACH or Seattle. The time to reach foot flat was also significantly reduced for the Golden-Ankle in comparison to both the others. Because the cosmetic material of the SACH foot can store or dissipate and then recover as much energy as the Seattle foot, the SACH foot should be considered an energy-storing foot. Finally, the net efficiency alone can not discriminate adequately among different types of prosthetic feet; therefore, one should consider the time to reach foot flat and the amount of energy recovered as additional objective criteria (weight, maintenance, and cosmesis) for selection of a prosthetic foot device.

  2. Area density of localization-entropy II: double cone-localization and quantum origin of the Bondi-Metzner-Sachs symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Schroer, Bert

    2006-04-15

    The holographic encoding is generalized to subalgebras of QFT localized in double cones. It is shown that as a result of this radically different spacetime encoding the modular group acts geometrically on the holographic image. As a result we obtain a formula for localization entropy which is identical to the previously derived formula for the wedge-localized subalgebra. The symmetry group in the holographic encoding turns out to be the Bondi-Metzner-Sachs group. (author)

  3. The Conventional Non-Articulated SACH or a Multiaxial Prosthetic Foot for Hypomobile Transtibial Amputees? A Clinical Comparison on Mobility, Balance, and Quality of Life

    Directory of Open Access Journals (Sweden)

    Francesco Paradisi

    2015-01-01

    Full Text Available The effects of a non-articulated SACH and a multiaxial foot-ankle mechanism on the performance of low-activity users are of great interest for practitioners in amputee rehabilitation. The aim of this study is to compare these two prosthetic feet and assess possible improvements introduced by the increased degrees of freedom provided by the multiaxial foot. For this purpose, a group of 20 hypomobile transtibial amputees (TTAs had their usual SACH replaced with a multiaxial foot. Participants’ functional mobility, involving ambulatory skills in overground level walking, ramps, and stairs, was evaluated by performing Six-Minute Walking Test (6MWT, Locomotor Capability Index-5 (LCI-5, Hill Assessment Index (HAI, and Stair Assessment Index (SAI. Balance performances were assessed using Berg Balance Scale (BBS and analysing upper body accelerations during gait. Moreover, the Prosthesis Evaluation Questionnaire (PEQ was performed to indicate the prosthesis-related quality of life. Results showed that participants walked faster using the multiaxial foot (p<0.05 maintaining the same upright gait stability. Significant improvements with the multiaxial foot were also observed in BBS, LCI-5, and SAI times and 4 of 9 subscales of the PEQ. Our findings demonstrate that a multiaxial foot represents a considerable alternative solution with respect to the conventional SACH in the prosthetic prescription for hypomobile TTAs.

  4. The Conventional Non-Articulated SACH or a Multiaxial Prosthetic Foot for Hypomobile Transtibial Amputees? A Clinical Comparison on Mobility, Balance, and Quality of Life.

    Science.gov (United States)

    Paradisi, Francesco; Delussu, Anna Sofia; Brunelli, Stefano; Iosa, Marco; Pellegrini, Roberto; Zenardi, Daniele; Traballesi, Marco

    2015-01-01

    The effects of a non-articulated SACH and a multiaxial foot-ankle mechanism on the performance of low-activity users are of great interest for practitioners in amputee rehabilitation. The aim of this study is to compare these two prosthetic feet and assess possible improvements introduced by the increased degrees of freedom provided by the multiaxial foot. For this purpose, a group of 20 hypomobile transtibial amputees (TTAs) had their usual SACH replaced with a multiaxial foot. Participants' functional mobility, involving ambulatory skills in overground level walking, ramps, and stairs, was evaluated by performing Six-Minute Walking Test (6 MWT), Locomotor Capability Index-5 (LCI-5), Hill Assessment Index (HAI), and Stair Assessment Index (SAI). Balance performances were assessed using Berg Balance Scale (BBS) and analysing upper body accelerations during gait. Moreover, the Prosthesis Evaluation Questionnaire (PEQ) was performed to indicate the prosthesis-related quality of life. Results showed that participants walked faster using the multiaxial foot (p foot were also observed in BBS, LCI-5, and SAI times and 4 of 9 subscales of the PEQ. Our findings demonstrate that a multiaxial foot represents a considerable alternative solution with respect to the conventional SACH in the prosthetic prescription for hypomobile TTAs.

  5. An MRI Von Economo - Koskinas atlas.

    Science.gov (United States)

    Scholtens, Lianne H; de Reus, Marcel A; de Lange, Siemon C; Schmidt, Ruben; van den Heuvel, Martijn P

    2016-12-28

    The cerebral cortex displays substantial variation in cellular architecture, a regional patterning that has been of great interest to anatomists for centuries. In 1925, Constantin von Economo and George Koskinas published a detailed atlas of the human cerebral cortex, describing a cytoarchitectonic division of the cortical mantle into over 40 distinct areas. Von Economo and Koskinas accompanied their seminal work with large photomicrographic plates of their histological slides, together with tables containing for each described region detailed morphological layer-specific information on neuronal count, neuron size and thickness of the cortical mantle. Here, we aimed to make this legacy data accessible and relatable to in vivo neuroimaging data by constructing a digital Von Economo - Koskinas atlas compatible with the widely used FreeSurfer software suite. In this technical note we describe the procedures used for manual segmentation of the Von Economo - Koskinas atlas onto individual T1 scans and the subsequent construction of the digital atlas. We provide the files needed to run the atlas on new FreeSurfer data, together with some simple code of how to apply the atlas to T1 scans within the FreeSurfer software suite. The digital Von Economo - Koskinas atlas is easily applicable to modern day anatomical MRI data and is made publicly available online.

  6. Positive Effekte von NSAR auf den Gastrointestinaltrakt

    Directory of Open Access Journals (Sweden)

    Lang M

    2015-01-01

    Full Text Available Ein protektiver Effekt von nichtsteroidalen Antirheumatika (NSAR auf die Tumorentstehung im Kolon wird in diversen präklinischen, epidemiologischen und auch randomisierten Arbeiten postuliert. Der Hauptwirkungsmechanismus von NSAR wird der Hemmung der Prostaglandinsynthese über die Cyclooxygenasen (COX zugeschrieben. Es existieren aber auch COX-unabhängige Mechanismen. Hier wollen wir einen Überblick über die Studienlage mit Aspirin, Sulindac und COX-2-Hemmern im Hinblick auf die Entstehung von Adenomen und Kolorektalkarzinomen geben. Die Wirkung dieser Substanzen ist besonders für Patienten mit familiärer Disposition relevant, aber auch für Patienten, die NSAR oder Aspirin aufgrund anderer Indikationen einnehmen. Es bestehen Abhängigkeiten von Dosis und Zeit sowie Interaktionen mit speziellen Mutationen (BRAF, PI3K und der zellulären COX-2-Expression. Beim Lynch-Syndrom ist die Wirksamkeit von Aspirin letztlich nicht sicher und eine multinationale klinische Studie mit 5-Aminosalizylsäure (Mesalazin wurde vom europäischen TRANSCAN-Programm gefördert.

  7. Arthroscopic Bankart repair combined with remplissage technique for the treatment of anterior shoulder instability with engaging Hill-Sachs lesion: a report of 49 cases with a minimum 2-year follow-up.

    Science.gov (United States)

    Zhu, Yi-Ming; Lu, Yi; Zhang, Jin; Shen, Jie-Wei; Jiang, Chun-Yan

    2011-08-01

    Engaging Hill-Sachs lesions are known to be a risk factor for recurrence dislocation after arthroscopic repair in patients with anterior shoulder instability. For a large engaging Hill-Sachs lesion, arthroscopic remplissage is a solution. Arthroscopic Bankart repair combined with the Hill-Sachs remplissage technique can achieve good results without significant impairment of shoulder function. Case Series; Level of evidence, 4. Forty-nine consecutive patients who underwent arthroscopic Bankart repair and Hill-Sachs remplissage for anterior shoulder instability were followed up for a mean duration of 29.0 months (range, 24-35 months). There were 42 males and 7 females with a mean age of 28.4 years (range, 16.7-54.7 years). All patients had diagnosed traumatic unidirectional anterior shoulder instability with a bony lesion of glenoid and an engaging Hill-Sachs lesion. Physical examination, radiographs, and magnetic resonance imaging were performed during postoperative follow-up. The American Shoulder and Elbow Surgeons (ASES) score, Constant score, and Rowe score were used to evaluate shoulder function. The active forward elevation increased a mean of 8.0° (range, -10° to 80°) postoperatively. However, the patients lost 1.9° (range, -40° to 30°) of external rotation to the side. Significant improvement was detected with regard to the ASES score (84.7 vs 96.0, P lesion was shown by magnetic resonance imaging. Arthroscopic Bankart repair combined with Hill-Sachs remplissage can restore shoulder stability without significant impairment of shoulder function in patients with engaging Hill-Sachs lesions.

  8. Doença de von Willebrand e anestesia Enfermedad de von Willebrand y anestesia Von Willebrand's disease and anesthesia

    Directory of Open Access Journals (Sweden)

    Fabiano Timbó Barbosa

    2007-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A doença de von Willebrand ocorre devido à mutação no cromossomo 12 e é caracterizada por deficiência qualitativa ou quantitativa do fator de von Willebrand. A diversidade de mutações leva ao aparecimento das mais variadas manifestações clínicas possibilitando a divisão dos pacientes em vários tipos e subtipos clínicos. A coagulopatia se manifesta basicamente através da disfunção plaquetária associada à diminuição dos níveis séricos do fator VIII coagulante. O objetivo dessa revisão foi mostrar os cuidados relacionados aos pacientes portadores da doença de von Willebrand durante o período perioperatório. CONTEÚDO: Foram definidas as características da doença de von Willebrand quanto à fisiopatologia, à classificação, ao diagnóstico laboratorial, ao tratamento atual e aos cuidados com o manuseio do paciente no período perioperatório. CONCLUSÕES: A doença de von Willebrand é o distúrbio hemorrágico hereditário mais comum, porém ela é subdiagnosticada pela complexidade da própria doença. A correta classificação do paciente, o uso apropriado da desmopressina e a transfusão do fator de von Willebrand são medidas fundamentais para a realização do procedimento anestésico bem-sucedido.JUSTIFICATIVA Y OBJETIVOS: La enfermedad de von Willebrand ocurre debido a la mutación en el cromosoma 12 y se caracteriza por la deficiencia cualitativa o cuantitativa del factor de von Willebrand. La diversidad de mutaciones conlleva al aparecimiento de las más variadas manifestaciones clínicas posibilitando la división de los pacientes en varios tipos y subtipos clínicos. La coagulopatía se manifiesta básicamente a través de la disfunción plaquetaria asociada con la disminución de los niveles séricos del factor VIII coagulante. El objetivo de esa revisión fue mostrar los cuidados relacionados con las pacientes portadoras de la enfermedad de von Willebrand durante el per

  9. Kerttu Wagner. Die historischen romane von Jaan Kross / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    2001-01-01

    Arvustus: Wagner, Kerttu. Die historischen Romane von Jaan Kross : am Beispiel einer Untersuchung der deutschen und englischen Übersetzungen von "Professor Martensi ärasõit" (1984). Frankfurt am Main [etc.] : P. Lang, 2001.

  10. Kerttu Wagner. Die historischen romane von Jaan Kross / Wolfgang Drechsler

    Index Scriptorium Estoniae

    Drechsler, Wolfgang, 1963-

    2001-01-01

    Arvustus: Wagner, Kerttu. Die historischen Romane von Jaan Kross : am Beispiel einer Untersuchung der deutschen und englischen Übersetzungen von "Professor Martensi ärasõit" (1984). Frankfurt am Main [etc.] : P. Lang, 2001.

  11. Von Willebrand's disease: case report and review of literature ...

    African Journals Online (AJOL)

    Abstract. Von Willebrand Disease (VWD) is the most common human ... The most bleeding forms of VWD usually do not concern type 1 patients with the ... and collagen binding test and genanalysis allow diagnosing the different types of von.

  12. Gemeinsam hilfreich oder einsam lästig? Beurteilung von praktikumsbegleitenden Weblogs von angehenden Lehrpersonen

    Directory of Open Access Journals (Sweden)

    Nives Egger

    2017-02-01

    Full Text Available Weblogs werden an Hochschulen vermehrt zur Unterstützung von Lern- und Reflexionsprozessen eingesetzt, in der Lehrer/innenbildung auch zunehmend während der berufspraktischen Ausbildung. Die Studierenden beurteilen den Einsatz von Weblogs jedoch unterschiedlich. Dabei ist wenig bekannt, welchen Einfluss die Vergabe und das Erhalten von Peerfeedback auf den Beurteilungsprozess von praktikumsbegleitenden Weblogs sowie auf den Umfang von Blogpostings haben. Im folgenden Beitrag wird dieser Frage mittels einer Befragung von 74 angehenden Lehrpersonen nachgegangen, die praktikumsbegleitende Weblogs mit oder ohne Peerfeedback nutzten, um über herausfordernde Ereignisse im Praktikum zu reflektieren. Die Ergebnisse zeigen, dass Studierende, die Peerfeedback erhielten und andere Blogbeiträge kommentierten, den Weblogeinsatz nützlicher einschätzen sowie eine höhere Motivation und positivere Einstellung gegenüber den Einsatz von Weblogs aufweisen als Studierende, die ohne Peerfeedback bloggen. Keinen Einfluss hat Peerfeedback auf den Umfang der Blogbeiträge und auf die dafür aufgewendete Zeit.

  13. Liouville-von Neumann molecular dynamics

    Science.gov (United States)

    Jakowski, Jacek; Morokuma, Keiji

    2009-06-01

    We present a novel first principles molecular dynamics scheme, called Liouville-von Neumann molecular dynamics, based on Liouville-von Neumann equation for density matrices propagation and Magnus expansion of the time-evolution operator. The scheme combines formally accurate quantum propagation of electrons represented via density matrices and a classical propagation of nuclei. The method requires a few iterations per each time step where the Fock operator is formed and von Neumann equation is integrated. The algorithm (a) is free of constraint and fictitious parameters, (b) avoids diagonalization of the Fock operator, and (c) can be used in the case of fractional occupation as in metallic systems. The algorithm is very stable, and has a very good conservation of energy even in cases when a good quality conventional Born-Oppenheimer molecular dynamics trajectories is difficult to obtain. Test simulations include initial phase of fullerene formation from gaseous C2 and retinal system.

  14. Gasification of liquid manure; Vergasung von Guelle

    Energy Technology Data Exchange (ETDEWEB)

    Gudenau, H.W.; Hoberg, H.; Hirsch, U. [Technische Hochschule Aachen (Germany). Inst. fuer Eisenhuettenkunde

    1996-12-31

    The potential of thermal use of liquid manure is investigated. It is recommended to separate the liquid and solid fraction. While the liquid fraction can be used as fertilizer, the solid fraction can be used for generating a fuel gas for combined heat and power generation. (orig) [Deutsch] Die Untersuchungen haben ergeben, dass in der thermischen Verwertung von Guelle ein bisher nur wenig genutztes Potential vorliegt. Die zum Anbau von Getreide notwendige Duengung kann durch Separation von Guelle in Fest- und Duennfraktion effektiver und kostenguenstiger durchgefuehrt werden. Der Naehrstoffgehalt des Guellefeststoffs sollte durch thermische Aufbereitung aufkonzentriert werden, so dass eine Vermarktung auch mit laengeren Transpoertwegen darstellbar ist. Die bei der thermischen Behandlung gewonnene Waerme kann prozessintern genutzt und ueberschuessige Waerme an Abnehmer in der naeheren Umgebung geliefert werden. Genauso besteht die Moeglichkeit, ein Brenngas zu erzeugen und die Energie mit Kraft-Waerme-Kopplung zu nutzen. (orig)

  15. Multivariate Herkunftsanalyse von Marmor auf petrographischer und geochemischer Basis

    OpenAIRE

    Cramer, Thomas

    2004-01-01

    Am Beispiel von aus Kleinasien stammenden Grabungsfunden in der Antikensammlung Berlin wird die Methodik der Herkunftsanalyse von Marmoren, d.h. der Zuordnung zu ihren Lagerstätten, weiterentwickelt und erprobt. Dazu wird der aktuelle Forschungsstand kritisch gewürdigt, die Voraussetzungen, Bedingungen und Grenzen der Provenienzbestimmung werden systematisiert und von den zahlreichen Gesteinsmerkmalen und Untersuchungsmethoden die geeignetsten ausgewählt. Marmore von 38 Sammlungsobjekten, die...

  16. Experimentelle Untersuchung von Konzentrations- und Verweilzeiteffekten in Membranreaktoren

    OpenAIRE

    Tota, A.; Hamel, C.; Thomas, S.; Joshi, M.; Klose, F.; Seidel-Morgenstern, A.

    2003-01-01

    Heterogen katalysierte Oxidationsreaktionen von kurzkettigen Kohlenwasserstoffen werden in der Industrie zur Erzeugung von Ausgangsmaterialien für wertvollere Syntheseprodukte (selektive Oxidation) oder zur Entsorgung von Abgasen eingesetzt. Bei selektiven Oxidationen ist das gewünschte Produkt gewöhnlich ein thermodynamisch instabiles Zwischenprodukt. Mit dem Einsatz von Membranreaktoren verspricht man sich hohe Selektivitäten. bei gleichzeitig hohen Ausbeuten. Als Modellreaktion für systema...

  17. Mortality incidence estimation using federal death certificate and natality data with an application to Tay-Sachs disease.

    Science.gov (United States)

    Jalal, Kabir; Carter, Randy L

    2015-09-01

    For confidentiality reasons, US federal death certificate data are incomplete with regards to the dates of birth and death for the decedents, making calculation of total lifetime of a decedent impossible and thus estimation of mortality incidence difficult. This paper proposes the use of natality data and an imputation-based method to estimate age-specific mortality incidence rates in the face of this missing information. By utilizing previously determined probabilities of birth, a birth date and death date are imputed for every decedent in the dataset. Thus, the birth cohort of each individual is imputed, and the total on-study time can be calculated. This idea is implemented in two approaches for estimation of mortality incidence rates. The first is an extension of a person-time approach, while the second is an extension of a life table approach. Monte Carlo simulations showed that both approaches perform well in comparison to the ideal complete data methods, but that the person-time method is preferred. An application to Tay-Sachs disease is demonstrated. It is concluded that the imputation methods proposed provide valid estimates of the incidence of death from death certificate data without the need for additional assumptions under which usual mortality rates provide valid estimates.

  18. Single-channel current recordings of acetylcholine receptors in electroplax isolated from the Electrophorus electricus Main and Sachs' electric organs.

    Science.gov (United States)

    Pasquale, E B; Udgaonkar, J B; Hess, G P

    1986-01-01

    Extensive chemical kinetic measurements of acetylcholine receptor-controlled ion translocation in membrane vesicles isolated from the electroplax of Electrophorus electricus have led to the proposal of a minimum model which accounts for the activation, desensitization, and voltage-dependent inhibition of the receptor by acetylcholine, suberyldicholine, and carbamoylcholine. Comparison of chemical kinetic measurements of the dynamic properties of the acetylcholine receptor in vesicles with the properties of the receptor in cells obtained from the same organ and animal have been hampered by an inability to make the appropriate measurements with Electrophorus electricus electroplax cells. Here we report a method for exposing and cleaning the surface of electroplax cells obtained from both the Main electric organ and the organ of Sachs and the results of single-channel current recordings which have now become possible. The single-channel current recordings were made in the presence of either carbamoylcholine or suberyldicholine, as a function of temperature and transmembrane voltage. Both the channel open times and the single-channel conductance were measured. The data were found to be consistent with the model based on chemical kinetic measurements using receptor-rich membrane vesicles prepared from the Main electric organ of E. electricus.

  19. Tay-Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum-associated degradation.

    Science.gov (United States)

    Dersh, Devin; Iwamoto, Yuichiro; Argon, Yair

    2016-12-01

    Loss of function of the enzyme β-hexosaminidase A (HexA) causes the lysosomal storage disorder Tay-Sachs disease (TSD). It has been proposed that mutations in the α chain of HexA can impair folding, enzyme assembly, and/or trafficking, yet there is surprisingly little known about the mechanisms of these potential routes of pathogenesis. We therefore investigated the biosynthesis and trafficking of TSD-associated HexA α mutants, seeking to identify relevant cellular quality control mechanisms. The α mutants E482K and G269S are defective in enzymatic activity, unprocessed by lysosomal proteases, and exhibit altered folding pathways compared with wild-type α. E482K is more severely misfolded than G269S, as observed by its aggregation and inability to associate with the HexA β chain. Importantly, both mutants are retrotranslocated from the endoplasmic reticulum (ER) to the cytosol and are degraded by the proteasome, indicating that they are cleared via ER-associated degradation (ERAD). Leveraging these discoveries, we observed that manipulating the cellular folding environment or ERAD pathways can alter the kinetics of mutant α degradation. Additionally, growth of patient fibroblasts at a permissive temperature or with chemical chaperones increases cellular Hex activity by improving mutant α folding. Therefore modulation of the ER quality control systems may be a potential therapeutic route for improving some forms of TSD.

  20. A novel mutation in the HEXA gene specific to Tay-Sachs disease carriers of Jewish Iraqi origin.

    Science.gov (United States)

    Karpati, M; Peleg, L; Gazit, E; Akstein, E; Goldman, B

    2000-05-01

    An increased frequency of carriers of 1:140, as defined by reduced hexosaminidase A (HexA) activity, was observed among Iraqi Jews participating in the Tay-Sachs disease (TSD) carrier detection program. Prior to this finding, TSD among Jews had been restricted to those of Eastern European (Ashkenazi) and Moroccan descent with carrier frequencies of 1:29 and 1:110 for Jews of Ashkenazi and Moroccan extraction, respectively. A general, pan-ethnic frequency of approximately 1:280 has been observed among other Jewish Israeli populations. Analysis of 48 DNA samples from Iraqi Jews suspected, by enzymatic assay, to be carriers revealed a total of five mutations, one of which was novel. In nine carriers (19%), a known mutation typical to either Ashkenazi or Moroccan Jews was identified. DeltaF304/ 305 was detected in four individuals, and + 1278TATC in three. G269S and R170Q each appeared in a single person. The new mutation, G749T, resulting in a substitution of glycine to valine at position 250 has been found in 19 of the DNA samples (40%). This mutation was not detected among 100 non-carrier, Iraqi Jews and 65 Ashkenazi enzymatically determined carriers. Aside from Ashkenazi and Moroccan Jews, a specific mutation in the HEXA gene has now also been identified in Jews of Iraqi descent.

  1. Parameter estimation biases due to contributions from the Rees-Sciama effect to the integrated Sachs-Wolfe spectrum

    CERN Document Server

    Schaefer, Bjoern Malte; Heisenberg, Lavinia

    2010-01-01

    The subject of this paper is an investigation of the nonlinear contributions to the spectrum of the integrated Sachs-Wolfe (iSW) effect. We derive the corrections to the iSW-auto spectrum and the iSW-tracer cross-spectrum consistently to third order in perturbation theory and analyse the cumulative signal-to-noise ratio for a cross-correlation between the PLANCK and EUCLID data sets as a function of multipole order. We quantify the parameter sensitivity and the statistical error bounds on the cosmological parameters Omega_m, sigma_8, h, n_s and w from the linear iSW-effect and the systematical parameter estimation bias due to the nonlinear corrections in a Fisher-formalism, analysing the error budget in its dependence on multipole order. Our results include: (i) the spectrum of the nonlinear iSW-effect can be measured with 0.8\\sigma statistical significance, (ii) nonlinear corrections dominate the spectrum starting from l=100, (iii) an anticorrelation of the CMB temperature with tracer density on high multipo...

  2. Parameter estimation biases due to contributions from the Rees-Sciama effect to the integrated Sachs-Wolfe spectrum

    Science.gov (United States)

    Schäfer, Björn Malte; Kalovidouris, Angelos Fotios; Heisenberg, Lavinia

    2011-09-01

    The subject of this paper is an investigation of the non-linear contributions to the spectrum of the integrated Sachs-Wolfe (iSW) effect. We derive the corrections to the iSW autospectrum and the iSW-tracer cross-spectrum consistently to third order in perturbation theory and analyse the cumulative signal-to-noise ratio for a cross-correlation between the Planck and Euclid data sets as a function of multipole order. We quantify the parameter sensitivity and the statistical error bounds on the cosmological parameters Ωm, σ8, h, ns and w from the linear iSW effect and the systematical parameter estimation bias due to the non-linear corrections in a Fisher formalism, analysing the error budget in its dependence on multipole order. Our results include the following: (i) the spectrum of the non-linear iSW effect can be measured with 0.8σ statistical significance, (ii) non-linear corrections dominate the spectrum starting from ℓ≃ 102, (iii) an anticorrelation of the CMB temperature with tracer density on high multipoles in the non-linear regime, (iv) a much weaker dependence of the non-linear effect on the dark energy model compared to the linear iSW effect and (v) parameter estimation biases amount to less than 0.1σ and weaker than other systematics.

  3. Tay-Sachs Carrier Screening by Enzyme and Molecular Analyses in the New York City Minority Population.

    Science.gov (United States)

    Mehta, Nikita; Lazarin, Gabriel A; Spiegel, Erica; Berentsen, Kathleen; Brennan, Kelly; Giordano, Jessica; Haque, Imran S; Wapner, Ronald

    2016-09-01

    Carrier screening for Tay-Sachs disease is performed by sequence analysis of the HEXA gene and/or hexosaminidase A enzymatic activity testing. Enzymatic analysis (EA) has been suggested as the optimal carrier screening method, especially in non-Ashkenazi Jewish (non-AJ) individuals, but its utilization and efficacy have not been fully evaluated in the general population. This study assesses the reliability of EA in comparison with HEXA sequence analysis in non-AJ populations. Five hundred eight Hispanic and African American patients (516 samples) had EA of their leukocytes performed and 12 of these patients who tested positive by EA ("carriers") had subsequent HEXA gene sequencing performed. Of the 508 patients, 25 (4.9%) were EA positive and 40 (7.9%) were inconclusive. Of the 12 patients who were sequenced, 11 did not carry a pathogenic variant and one carried a likely deleterious mutation (NM_000520.4(HEXA):c.1510C>T). High inconclusive rates and poor correlation between positive/inconclusive enzyme results and identification of pathogenic mutations suggest that ethnic-specific recalibration of reference ranges for EA may be necessary. Alternatively, HEXA gene sequencing could be performed.

  4. Doença de Tay-Sachs em criança de raça negra

    Directory of Open Access Journals (Sweden)

    Sérgio Rosemberg

    1970-12-01

    Full Text Available É relatado um caso de doença de Tay-Sachs em criança da raça negra. O encontro desta entidade em indivíduos não judeus é bastante raro, sendo este o quinto caso descrito em criança negra. Os autores estudam alguns aspectos genéticos, chegando à conclusão de que o cálculo da freqüência do gene mutante é impossível devido ao pequeno número de casos e ao fato de que não há estimativas seguras quanto à taxa de nascimento de indivíduos negros na população, Em que pese o fato de o diagnóstico se assentar em bases puramente clínicas e anatômicas, prescindindo os autores de exames bioquímicos específicos, os dados apresentados são congruentes com os casos clássicos descritos na literatura.

  5. Tay–Sachs disease mutations in HEXA target the α chain of hexosaminidase A to endoplasmic reticulum–associated degradation

    Science.gov (United States)

    Dersh, Devin; Iwamoto, Yuichiro; Argon, Yair

    2016-01-01

    Loss of function of the enzyme β-hexosaminidase A (HexA) causes the lysosomal storage disorder Tay–Sachs disease (TSD). It has been proposed that mutations in the α chain of HexA can impair folding, enzyme assembly, and/or trafficking, yet there is surprisingly little known about the mechanisms of these potential routes of pathogenesis. We therefore investigated the biosynthesis and trafficking of TSD-associated HexA α mutants, seeking to identify relevant cellular quality control mechanisms. The α mutants E482K and G269S are defective in enzymatic activity, unprocessed by lysosomal proteases, and exhibit altered folding pathways compared with wild-type α. E482K is more severely misfolded than G269S, as observed by its aggregation and inability to associate with the HexA β chain. Importantly, both mutants are retrotranslocated from the endoplasmic reticulum (ER) to the cytosol and are degraded by the proteasome, indicating that they are cleared via ER-associated degradation (ERAD). Leveraging these discoveries, we observed that manipulating the cellular folding environment or ERAD pathways can alter the kinetics of mutant α degradation. Additionally, growth of patient fibroblasts at a permissive temperature or with chemical chaperones increases cellular Hex activity by improving mutant α folding. Therefore modulation of the ER quality control systems may be a potential therapeutic route for improving some forms of TSD. PMID:27682588

  6. Dependence of deformation mechanisms on grain orientations and their changes calculated based on Sachs model in magnesium alloy AZ31

    Institute of Scientific and Technical Information of China (English)

    Qing-ge XIE; Ping YANG; Li MENG

    2008-01-01

    During deformation, the orientation of a grain influences not only the deformation mechanisms (slip or twinning) and the specific selection of activated slip or twinning systems for that grain, but also the kinetics of different types of transformation. Schmid factor analysis was applied to determine the orientation dependency of deformation mechanisms in magnesium alloys AZ31 in this work. The orientation changes after the operation of the specific deformation mechanisms were also calcu-lated based on Sachs model. It was found that different deformation mechanisms proceeded differently according to theoretical predictions. Basal slip occurred when basal planes of grains were tilted toward ND around TD. Prismatic slip dominated when basal planes were approxi-mately perpendicular to TD. Calculation results also indi-cated that the operating of pyramidal slip can not be neglected. {10 12} twinning was favorable when basal planes were approximately normal to RD and { 10 11 } twinning was analyzed to be related to the grains with basal orientations. The operating of slip could greatly suppress the activating of twinning by our Schmid factor analysis. Basal orientations with TD and RD scattering can favor basal slip and tension twinning, respectively, after the operation of compression twinning based on the Schmid factor calculations.

  7. Contributions to the nonlinear integrated Sachs-Wolfe effect: Birkinshaw-Gull effect and gravitational self-energy density

    CERN Document Server

    Merkel, Philipp

    2012-01-01

    In this paper, we recompute contributions to the spectrum of the nonlinear integrated Sachs-Wolfe (iSW)/Rees-Sciama effect in a dark energy cosmology. Focusing on the moderate nonlinear regime, all dynamical fields involved are derived from the density contrast in Eulerian perturbation theory. Shape and amplitude of the resulting angular power spectrum are similar to that derived in previous work. With our purely analytical approach we identify two distinct contributions to the signal of the nonlinear iSW-effect: the change of the gravitational self-energy density of the large scale structure with (conformal) time and gravitational lenses moving with the large scale matter stream. In the latter we recover the Birkinshaw-Gull effect. As the nonlinear iSW-effect itself is inherently hard to detect, observational discrimination between its individual contributions is almost excluded. Our analysis, however, yields valuable insights into the theory of the nonlinear iSW-effect as a post-Newtonian relativistic effec...

  8. Approximate equivalence in von Neumann algebras

    Institute of Scientific and Technical Information of China (English)

    DING; Huiru; Don; Hadwin

    2005-01-01

    One formulation of D. Voiculescu's theorem on approximate unitary equivalence is that two unital representations π and ρ of a separable C*-algebra are approximately unitarily equivalent if and only if rank o π = rank o ρ. We study the analog when the ranges of π and ρ are contained in a von Neumann algebra R, the unitaries inducing the approximate equivalence must come from R, and "rank" is replaced with "R-rank" (defined as the Murray-von Neumann equivalence of the range projection).

  9. Von Mumien, Cyborgs und Röntgenbildern

    Directory of Open Access Journals (Sweden)

    Regina Schleicher

    2004-03-01

    Full Text Available Unter dem Titel Techniken der Reproduktion liegt ein Sammelband vor, der die Beiträge einer Tagung an der Universität Paderborn vom Dezember 2001 enthält. In enger Verknüpfung verschiedener disziplinärer Perspektiven werden Schlaglichter auf eine Vielzahl von Themen geworfen, die sich mit dem Begriff „Reproduktion“ verbinden. Dabei wird deutlich, wie eng die Geschichte der Medien und die Entwicklung von Technologien der biologischen Fortpflanzung miteinander verzahnt sind.

  10. Verwertung von Prozessbieren in der Brauerei

    OpenAIRE

    Schneeberger, Mark

    2007-01-01

    Die betriebsinterne Verwertung von Prozessbieren (PB) zur Minimierung des Bierschwandes stellt den Kern der Arbeit dar. Als mengenmäßig bedeutsamste PB haben sich Hefebiere (HB), Vor-, Zwischen- und Nachläufe (VZNL) aus der Filtration, Biere aus unterfüllten bzw. falsch etikettierten Flaschen aus der Abfüllung sowie Rückbiere herausgestellt. Verschiedene Indikatoren in Hefezellen und im HB wurden zur Kontrolle von Hefebierrückgewinnungsanlagen ermittelt. Um eine hohe Qualität der wiedergewinn...

  11. [Anja Wilhelmi. Lebensweltlen von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien] / Alexander Ewig

    Index Scriptorium Estoniae

    Ewig, Alexander, 1980-

    2011-01-01

    Arvustus: Wilhelmi, Anja. Lebenswelten von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien. (Veröffentlichungen des Nordost-Instituts, 10.) (Wiesbaden : HArrassowitz 2008)

  12. [Anja Wilhelmi. Lebensweltlen von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien] / Alexander Ewig

    Index Scriptorium Estoniae

    Ewig, Alexander, 1980-

    2011-01-01

    Arvustus: Wilhelmi, Anja. Lebenswelten von Frauen der deutschen Oberschicht im Baltikum (1800-1939). Eine Untersuchung anhand von Autobiographien. (Veröffentlichungen des Nordost-Instituts, 10.) (Wiesbaden : HArrassowitz 2008)

  13. Die Verteilung und Eigenschaften von Bodenformen in der Deutschen Bucht, eine Rekonstruktion der Karten von Ulrich (1973)

    DEFF Research Database (Denmark)

    Winter, Christian; Lefebvre, Alice; Benninghoff, Markus

    2015-01-01

    Entstehung, Gestalt und Dynamik von Bodenformen in vergleichsweise kleinen Untersuchungsgebieten ist die Arbeit von ULRICH (1973) über die Verteilung von Bodenformen in der Deutschen Bucht bis heute die einzige verfügbare zusammenhängende Darstellung für die deutsche Nordseeküste. Die analogen Karten und die...

  14. Herstellung von Bio-Fleisch- und Wurstwaren ohne Einsatz von Pökelstoffen

    OpenAIRE

    2008-01-01

    Bei der ökologischen Herstellung von Fleisch- und Wurstwaren werden vielfach auf die in der konventionellen Wurstherstellung verwendeten Konservierungsstoffe E 250 (Natriumnitrit) bzw. E 252 (Kaliumnitrat) verzichtet oder reduzierte Zugabemengen der Zusatzstoffe verwendet.

  15. Der Briefwechsel zwischen Alexander von Humboldt und Karl Ernst von Baer

    Directory of Open Access Journals (Sweden)

    Thomas Schmuck

    2012-10-01

    Full Text Available Zusammenfassung Der kurze, nicht vollständig erhaltene Briefwechsel zwischen Alexander von Humboldt und Karl Ernst von Baer behandelt sehr verschiedene Themen: Politik, Kriegsgefahr, den Wissenschaftsbetrieb, Auszeichnungen und Tagungen, Embryologie und Cholera. Gemeinsam mit Briefen und Reden ergibt sich dabei ein differenziertes Bild der Beurteilung der beiden Wissenschaftler durch den jeweils anderen. Während Baer sich als Bewunderer Humboldts erweist, erscheint umgekehrt Humboldts Einschätzung Baers als ambivalent. Abstract The short, not completely preserved correspondence between Alexander von Humboldt and Karl Ernst von Baer deals with a wide range of subjects: politics and the danger of war, academic activities, scientific awards and conferences, aspects of embryology and the cholera. Letters to third persons and speeches, together with the correspondence between Humboldt and Baer show a differentiated pattern of mutual appraisal: While Baer always remained an admirer of the elder naturalist, Humboldt’s estimation was characterized by ambivalence.

  16. Von der Medienwirkungsbehauptung zur erziehungswissenschaftlichen Medienrezeptionsforschung. Vorschlag zur Analyse von Filmkommunikaten

    Directory of Open Access Journals (Sweden)

    Barbara Drinck

    2001-04-01

    Full Text Available Im Hinblick auf die Erforschung spezifischer Zusammenhänge von Medienkonsum und der Herausbildung von Einstellungen und Handlungen wird eine konstruktivistische Theorieorientierung plausibilisiert, indem zunächst auf den Stand der Medienwirkungsforschung eingegangen und vor dem Hintergrund einer begründeten Kritik des Wirkungsverständnisses auf die Notwendigkeit einer medienrezeptionswissenschaftlichen Forschungsalternative hingewiesen wird. Weiterhin wird der Stand der (erziehungswissenschaftlichen Medienrezeptionsforschung erörtert. Sodann werden Elemente einer konstruktivistischen Methodologie von Medienrezeptionsforschung beschrieben, die am Beispiel der Rezeption von Filmen konkretisiert werden. Dabei wird das Konzept des Kommunikates (S.J. Schmidt als Ausgangspunkt genommen, ein Vorschlag für eine Beschreibungssprache für (Film- Kommunikate entwickelt und eine Adaption des Ansatzes filmischer Narration zur Sprache gebracht.

  17. Auswirkung von Umweltchemikalien auf die Biologie von Chironomiden und Fischen als deren Prädatoren

    OpenAIRE

    Langer-Jaesrich, Miriam

    2012-01-01

    Im Rahmen der Dissertation wurden in mehreren Teilprojekten die Auswirkungen von Umweltchemikalien auf Chironomiden als Schlüsselorganismen in aquatisch-benthischen Lebensräumen untersucht. Dabei lag der Fokus besonders auf der Erfassung von nicht-standardisierten Endpunkten und Bioindikatoren sowie auf der Bearbeitung einer weiterführenden ökologisch relevanten Fragestellung zum Räuber-Beute-Verhältnis unter Schadstoffeinfluss. Im ersten Teil der Dissertation wurde das herkömmliche Standa...

  18. Synthese von grenzflächenaktiven Monomeren zur Herstellung von funktionalen Metall-Chalkogenid/Polymer-Hybridnanopartikeln

    OpenAIRE

    Fischer, V.

    2013-01-01

    In dieser Arbeit wurde gezeigt, wie oberflächenfunktionalisierte Polystyrolnanopartikel zur Herstellung von Metallchalkogenid/Polymer-Hybridnanopartikeln eingesetzt werden können. Dazu wurden zunächst phosphonsäure- und phosphorsäurefunktionalisierte Surfmere synthetisiert, die anschließend bei der Miniemulsionspolymerisation von Styrol verwendet wurden. Die Surfmere dienten dabei zugleich zur Stabilisierung und als Comonomer. Die oberflächenfunktionalisierten Polystyrolnanopartikel wurden an...

  19. Untersuchung der Rolle von Rhodopsin 7 und Cryptochrom im Sehprozess von Drosophila melanogaster

    OpenAIRE

    Grebler, Rudi

    2015-01-01

    Ausgangspunkt für die Detektion von Licht ist im gesamten Tierreich die Absorption von Photonen durch photorezeptive Proteine, die sogenannten Opsine und in geringerem Ausmaß die Typ 1 Cryptochrome. Die Taufliege Drosophila melanogaster besitzt sechs eingehend charakterisierte, auch als Rhodopsine bezeichnete Opsine (Rh1-Rh6) und ein Cryptochrom (CRY). Neben den Ocellen und den Hofbauer-Buchner Äuglein werden die Rhodopsine in erster Linie in den Photorezeptorzellen der Komplexaugen, den Haup...

  20. Untersuchungen zur Trockenentschwefelung von Brenngasen durch Partialoxidation von H2S an Herdofenkoks

    OpenAIRE

    Bauersfeld, Dirk

    2009-01-01

    Die vorliegende Arbeit befasst sich mit Untersuchungen zur Trockenentschwefelung von Brenngasen durch Partialoxidation von H2S an Herdofenkoks. Hierzu wurden Versuche in der Technikumsanlage VTE 2004 mit einem simulierten PHTW Gas durchgeführt. Es zeigte sich, dass der COS-Abbau nicht wie bisher angenommen durch die COS-Partialoxidation sondern durch die COS-Hydrolyse erfolgt. Die COS-Hydrolyse gewinnt dabei mit abnehmender Raumbelastung an Bedeutung. Der Entschwefelungsgrad erhöht sich mit s...

  1. Dentinhaftung von Zementen. Der Haftverbund von Zementen mit Dentin in Kombination mit verschiedenen indirekten Restaurationsmaterialien

    OpenAIRE

    Peutzfeldt, Anne; Sahafi, Alireza; Flury, Simon

    2011-01-01

    Einleitung: Die Anzahl zahnärztlicher Zemente sowie Restaurationsmaterialien steigt stetig. Die richtige Zementwahl für einen zuverlässigen Haftverbund zwischen Restaurationsmaterial und Zahnsubstanz ist von Interesse für den Kliniker. Ziel der vorliegenden in vitro-Studie war es daher, den Dentinhaftverbund von verschiedenen Zementen in Kombination mit verschiedenen indirekten Restaurationsmaterialien zu untersuchen. Material und Methoden: Zylindrische Probekörper aus sechs Restaurations...

  2. [The Costantin Von Economo's lethargic encefalitis

    Science.gov (United States)

    Pistacchio, E.

    1998-01-01

    Starting from the Constantin Von Economo's description of a "new" disease, the lethargic encephalitis, the author delineates the history of an infectious sleeping sickness that caused epidemics in Europe from 1917 to 1928 and led to create, in Italy, the "Institutes for Encephalitis".

  3. Die larvale Entwicklung von Chirocentrus dorab (Forsk.)

    NARCIS (Netherlands)

    Delsman, H.C.

    1922-01-01

    Wer sich mit dem Studium der Lebensweise indischer Fische befassen will, hat dabei den grossen Vorteil, sich beim Bestimmen der Species auf die zahlreichen Arbeiten BLEEKER’S stützen zu können, während ihm das Determinieren ganz besonders erleichtert wird durch das von dichotomischen Tabellen

  4. Soolopartiid Von Krahli katuse all / Kristi Eberhart

    Index Scriptorium Estoniae

    Eberhart, Kristi

    2007-01-01

    Von Krahli Teatri kolmest lavastusest: "Erki ja Tiina" (lavastaja Mart Kangro, tantsivad Erki Laur ja Tiina Tauraite), "Faust" (J. W. Goethe ainetel tekst ja lavastus Taavi Eelmaa, muusika ja laulud Chalice, osades Jarek Kasar ja Rein Pakk), "Hamletid" (William Shakespeare'i ainetel kontseptsiooni, lavastuse, koreograafia, kujunduse, valguse autor Sasha Pepeljajev, video- ja helikunstnik Taavet Jansen. Esitaja Juhan Ulfsak)

  5. Drei neue Chelonarium-Arten von Sumatra

    NARCIS (Netherlands)

    Reitter, Edm.

    1886-01-01

    Die Arten dieser Gattung kommen vorherschend in Central- und Süd-Amerika vor, doch sind in neuerer Zeit auch drei Arten: Ch. orientale Reitt. 1), conspersum Reitt. 2) und adspersum Chevrl.3) von den grossen Sunda-Inseln und Malakka bekannt geworden, zu denen nun weitere 3 Arten treten, die ich nachf

  6. Ueber eine Anomalie von Acromitus flagellatus (Stiasny)

    NARCIS (Netherlands)

    Stiasny, G.

    1934-01-01

    Bei erneuter Durchsicht des reichhaltigen Materiales von Acromitus flagellatus (Stiasny) in der Scyphomedusen-Sammlung des Rijksmuseum van Natuurlijke Historie in Leiden (vergl. meine Mitteilungen daruber, 1920, Uebersichtstabelle III und 1921, p. 131/136) fand ich ein Exemplar, das eine

  7. Ueber zwei neue Vogelarten von Java

    NARCIS (Netherlands)

    Finsch, O.

    1902-01-01

    Die beiden nachstehend beschriebenen Vögel wurden mir von Herrn Max Bartels als muthmasslich neu zugesandt. Die genaue Untersuchung hat dies bestätigt. Ich freue mich daher eine der Arten zu Ehren des Entdeckers benennen zu können. Seit einigen Jahren als Leiter der Plantage Pangerango bei Pasir Dat

  8. Active Von Willebrand Factor, thrombocytopenia and thrombosis

    NARCIS (Netherlands)

    Hulstein, J.J.J.

    2006-01-01

    Platelets and von Willebrand factor (VWF) are unable to interact in circulation. To induce an interaction, a conversion of VWF to a platelet-binding conformation is required. At higher shear stresses, the first step in thrombus formation is binding of VWF to the subendothelium. This results in expos

  9. The von Bertalanffy growth model for horticulture

    NARCIS (Netherlands)

    Tijskens, L.M.M.; Schouten, R.E.; Unuk, T.; Šumak, D.

    2017-01-01

    Traditionally, crop load and fruit yield from previous seasons are used as indicators for prediction of fruit size. Disregarding the inevitable biological variation between fruit, von Bertalanffy (1938) described the growth, expressed as length, of virtually any living organism. The model is here

  10. Von Kalifornien nach Taxham / Katri Soe

    Index Scriptorium Estoniae

    Soe, Katri, 1971-

    2005-01-01

    Neljas osa magistritööst "Von Kalifornien nach Taxham: Formen und Strukturen der Kommunikation in Peter Handkes Romanen "Der kurze Brief zum langen Abschied" und "In einer dunklen Nacht ging ich aus meinem stillen Haus"" (Tartu, 2000. Juhendaja: Claus Sommerhage)

  11. Ueber eine Anomalie von Acromitus flagellatus (Stiasny)

    NARCIS (Netherlands)

    Stiasny, G.

    1934-01-01

    Bei erneuter Durchsicht des reichhaltigen Materiales von Acromitus flagellatus (Stiasny) in der Scyphomedusen-Sammlung des Rijksmuseum van Natuurlijke Historie in Leiden (vergl. meine Mitteilungen daruber, 1920, Uebersichtstabelle III und 1921, p. 131/136) fand ich ein Exemplar, das eine bemerkenswe

  12. Zustandsschätzung von aktiven Fahrwerkregelsystemen

    NARCIS (Netherlands)

    Leenen, R.; Maurice, J.P.

    2010-01-01

    Eine Weiterentwicklung von Fahrdynamikregelung, Überroll- und Seitenaufprallschutz sowie Pre-Crash-Funktionen und Kollisionsminderung verspricht TNO. Mit einem System zur Beobachtung des aktuellen Fahrzeugzustands (Vehicle State Estimator – VSE) bietet der niederländische Zulieferer ein zentrales Mo

  13. Ueberreste vorweltlicher Proboscidier von Java und Banka

    NARCIS (Netherlands)

    Martin, K.

    1884-01-01

    Junghuhn führte in seinem Werke über Java nur einen einzigen Wirbelthierrest, Carcharias megalodon, an (7, IV, pag. 97); es war ihm nicht gelungen bei seinem ersten Aufenthalte auf der Insel Reste von Säugethieren zu finden, so eifrig er auch darnach in den Höhlen des Tertiaergebirges suchte (7, IV,

  14. Entendendo a entropia de von Neumann

    OpenAIRE

    Maziero, Jonas

    2015-01-01

    Revisamos os postulados da mecânica quântica necessários para discutir a entropia de von Neumann, que é introduzida como uma generalização da entropia de Shannon e propomos um jogo simples que facilita o entendimento do seu significado físico.

  15. Das Haarkleid eines Fetus von Schimpanse

    NARCIS (Netherlands)

    Bolk, L.

    1919-01-01

    In seiner ausführlichen Arbeit über die Richtung der Haare bei den Affenembryonen nebst allgemeinen Erörterungen über die Ursachen der Haarrichtungen, hat Schwalbe eine Fülle von Tatsachen und eine wertvolle kritische Betrachtung über das Problem der Haarrichtungen geliefert. Leider war der Autor ni

  16. A Drosophila protein family implicated in pheromone perception is related to Tay-Sachs GM2-activator protein.

    Science.gov (United States)

    Starostina, Elena; Xu, Aiguo; Lin, Heping; Pikielny, Claudio W

    2009-01-02

    Low volatility, lipid-like cuticular hydrocarbon pheromones produced by Drosophila melanogaster females play an essential role in triggering and modulating mating behavior, but the chemosensory mechanisms involved remain poorly understood. Recently, we showed that the CheB42a protein, which is expressed in only 10 pheromone-sensing taste hairs on the front legs of males, modulates progression to late stages of male courtship behavior in response to female-specific cuticular hydrocarbons. Here we report that expression of all 12 genes in the CheB gene family is predominantly or exclusively gustatory-specific, and occurs in many different, often non-overlapping patterns. Only the Gr family of gustatory receptor genes displays a comparable variety of gustatory-specific expression patterns. Unlike Grs, however, expression of all but one CheB gene is sexually dimorphic. Like CheB42a, other CheBs may therefore function specifically in gustatory perception of pheromones. We also show that CheBs belong to the ML superfamily of lipid-binding proteins, and are most similar to human GM2-activator protein (GM2-AP). In particular, GM2-AP residues involved in ligand binding are conserved in CheBs but not in other ML proteins. Finally, CheB42a is specifically secreted into the inner lumen of pheromone-sensing taste hairs, where pheromones interact with membrane-bound receptors. We propose that CheB proteins interact directly with lipid-like Drosophila pheromones and modulate their detection by the gustatory signal transduction machinery. Furthermore, as loss of GM2-AP in Tay-Sachs disease prevents degradation of GM2 gangliosides and results in neurodegeneration, the function of CheBs in pheromone response may involve biochemical mechanisms critical for lipid metabolism in human neurons.

  17. Gait Measures and Dynamic Weight bearing in Young and Elder Trans-tibal Amputee using PTB Prosthesis with SACH foot

    Directory of Open Access Journals (Sweden)

    Prasanna K. Lenka

    2008-12-01

    Full Text Available Objective: to investigate the changes associated with age in gait characteristics and dynamic weight bearing pattern of sound and prosthetic limb of persons with unilateral amputation. Participant: two groups of seven young (24±3.8 years and seven elderly unilateral amputee (71±6 years were selected for this study. Setting: both groups walked at their self selected speed over a 20 second duration plane surface walk way in trans-tibial prosthesis with PTB socket and SACH foot. The raw data of force and EMG sensors of gait analyzer were filtered, processed and analyzed with help of ‘matlab 7.0. A blue tooth enabled heart rate telemetry system was used for calculating gait efficiency in terms of physiological cost index (PCI. Results: significant differences were found in stride duration, (p=0.003, step duration sound limb (p<0.002, stance duration sound limb (p=0.002, stance duration prosthetic limb (p=0.006 and cadence (p=0.001<0.05, however no difference was found in EMG pattern of vastus lateralis between the two groups. The dynamic weight distribution showed more normalized load on anterior parts of heel and minimum load at calcaneal max in elderly group. The results of vertical ground reaction force found the prosthetic side of elderly group takes more weight than young group during loading response. In comparison, PCI was observed to be greater in case of elderly group. Conclusion: most of difference between two groups could be explained by speed variations and biomechanical limitation of ankle joint due to natural aging process.

  18. On the representation theory of the Bondi-Metzner-Sachs group and its variants in three space-time dimensions

    Science.gov (United States)

    Melas, Evangelos

    2017-07-01

    The original Bondi-Metzner-Sachs (BMS) group B is the common asymptotic symmetry group of all asymptotically flat Lorentzian radiating 4-dim space-times. As such, B is the best candidate for the universal symmetry group of General Relativity (G.R.). In 1973, with this motivation, McCarthy classified all relativistic B-invariant systems in terms of strongly continuous irreducible unitary representations (IRS) of B. Here we introduce the analogue B(2, 1) of the BMS group B in 3 space-time dimensions. B(2, 1) itself admits thirty-four analogues both real in all signatures and in complex space-times. In order to find the IRS of both B(2, 1) and its analogues, we need to extend Wigner-Mackey's theory of induced representations. The necessary extension is described and is reduced to the solution of three problems. These problems are solved in the case where B(2, 1) and its analogues are equipped with the Hilbert topology. The extended theory is necessary in order to construct the IRS of both B and its analogues in any number d of space-time dimensions, d ≥3 , and also in order to construct the IRS of their supersymmetric counterparts. We use the extended theory to obtain the necessary data in order to construct the IRS of B(2, 1). The main results of the representation theory are as follows: The IRS are induced from "little groups" which are compact. The finite "little groups" are cyclic groups of even order. The inducing construction is exhaustive notwithstanding the fact that B(2, 1) is not locally compact in the employed Hilbert topology.

  19. New exact solutions of Bianchi I, Bianchi III and Kantowski-Sachs spacetimes in scalar-coupled gravity theories via Noether gauge symmetries

    CERN Document Server

    Camci, U; Oz, I Basaran

    2016-01-01

    The Noether symmetry approach is useful tool to restrict the arbitrariness in a gravity theory when the equations of motion are underdetermined due to the high number of functions to be determined in the ansatz. We consider two scalar-coupled theories of gravity, one motivated by induced gravity, the other more standard; in Bianchi I, Bianchi III and Kantowski-Sachs cosmological models. For these models, we present a full set of Noether gauge symmetries, which are more general than those obtained by the strict Noether symmetry approach in our recent work. Some exact solutions are derived using the first integrals corresponding to the obtained Noether gauge symmetries.

  20. Infraspinatus strength assessment and ultrasound evaluation of posterior capsulotenodesis after arthroscopic hill-sachs remplissage in traumatic anterior glenohumeral instability: a retrospective controlled study protocol.

    Science.gov (United States)

    Merolla, Giovanni; Porcellini, Giuseppe

    2014-04-01

    Giovanni Merolla Co-investigator: Giuseppe Porcellini Investigation performed at the Biomechanics Laboratory "Marco Simoncelli", D. Cervesi Hospital, Cattolica - Italy PLAN OF CLINICAL INVESTIGATION (PCI): Version 1.0 of June 12, 2012 Approved by AV/IRST Ethical Committee (Comitato Etico Area Vasta Romagna) and authorized by AUSL RN ("Determina AUSL Rimini numero 326 del 29/03/2013: Remplissage U.O Chirurgia della Spalla - Valutazione clinica ed ultrasonografica dell'infraspinato dopo capsulo-tenodesi artroscopica (remplissage) nell'instabilità anteriore traumatica di spalla con lesione di Bankart e difetto omerale di Hill-Sachs").

  1. Martensitic transformation of pure iron at a grain boundary: Atomistic evidence for a two-step Kurdjumov-Sachs-Pitsch pathway

    Science.gov (United States)

    Meiser, Jerome; Urbassek, Herbert M.

    2016-08-01

    Using classical molecular dynamics simulations and the Meyer-Entel interaction potential, we study the martensitic transformation pathway in a pure iron bi-crystal containing a symmetric tilt grain boundary. Upon cooling the system from the austenitic phase, the transformation starts with the nucleation of the martensitic phase near the grain boundary in a plate-like arrangement. The Kurdjumov-Sachs orientation relations are fulfilled at the plates. During further cooling, the plates expand and merge. In contrast to the orientation relation in the plate structure, the complete transformation proceeds via the Pitsch pathway.

  2. Doença de von Willebrand e anestesia Enfermedad de von Willebrand y anestesia Von Willebrand's disease and anesthesia

    OpenAIRE

    Fabiano Timbó Barbosa; Rafael Martins da Cunha; Luciano Timbó Barbosa

    2007-01-01

    JUSTIFICATIVA E OBJETIVOS: A doença de von Willebrand ocorre devido à mutação no cromossomo 12 e é caracterizada por deficiência qualitativa ou quantitativa do fator de von Willebrand. A diversidade de mutações leva ao aparecimento das mais variadas manifestações clínicas possibilitando a divisão dos pacientes em vários tipos e subtipos clínicos. A coagulopatia se manifesta basicamente através da disfunção plaquetária associada à diminuição dos níveis séricos do fator VIII coagulante. O objet...

  3. Wir zeigen andere Bilder von Frauen ...

    Directory of Open Access Journals (Sweden)

    Bettina Rulofs

    2010-03-01

    Full Text Available Der vorliegende Beitrag beleuchtet die Bedeutung der Geschlechterordnung im Prozess der sportmedialen Kommunikation. Im Kern geht es um die Frage, inwiefern im Prozess der medialen Vermittlung von Sport traditionelle Geschlechterstereotype aufrechterhalten werden oder Möglichkeiten der Irritation solcher Stereotype bestehen. Dazu werden verschiedene Ebenen des massenmedialen Kommunikationsprozesses in den Blick genommen: die Medienprodukte, die Öffentlichkeitsarbeit und Selbst-Präsentation der Sportler/innen, die Medienrezeption und die Herstellungsprozesse von Medien in den Sportredaktionen. This article illustrates the relevance of gender in processes of sports media communication. The question in focus is in what way traditional gender stereotypes are perpetuated in the process of media communication in sport and how such stereotypes can be irritated. Therefore different levels of mass media communication are considered: the media products, the public relations of athletes and the presentation of themselves as athletes, the media-reception and the production processes in sport departments of media institutions.

  4. Von Neumann's Quantization of General Relativity

    CERN Document Server

    Arbuzov, A B; Cirilo-Lombardo, D J; Nazmitdinov, R G; Han, Nguyen Suan; Pavlov, A E; Pervushin, V N; Zakharov, A F

    2015-01-01

    Von Neumann's procedure is applied for quantization of General Relativity. We quantize the initial data of dynamical variables at the Planck epoch, where the Hubble parameter coincides with the Planck mass. These initial data are defined via the Fock simplex in the tangent Minkowskian space-time, the Dirac conformal interval. The Einstein cosmological principle is applied for the average of the spatial metric determinant logarithm over the spatial volume of the visible Universe. We derive the splitting of the general coordinate transformations into the diffeomorphisms (as the object of the second Noether theorem) and the initial data transformations (as objects of the first Noether theorem). Following von Neumann, we suppose that the vacuum state is a quantum ensemble. The vacuum state is degenerated with respect to quantum numbers of non-vacuum states with the distribution function that yields the Casimir effect in gravidynamics in analogy to the one in electrodynamics. The generation functional of the pertu...

  5. Integrales Lernen in und von Organisationen

    Directory of Open Access Journals (Sweden)

    Wendelin Kupers

    2006-06-01

    Full Text Available Bezogen auf das integrale Models von Ken Wilber untersucht der Beitrag die Bedeutung des Lernens in und von Organisationen. Nach einer Darstellung der Relevanz und des Grundverständnisses des Lernens im Organisationskontext, werden integrale Dimensionen des Lernens dargestellt. Im Einzelnen werden die verschiedenen Sphären eines inneren-subjektiven und äusseren-„objektiven“ Lernens des Einzelnen als auch ein gemeinschaftliches Lernen und Lernen im System auf der kollektiven Ebene dargestellt sowie deren interrelationaler Zusammenhang diskutiert. Schließlich beschreibt der Beitrag noch integrale Lernprozesse sowie integrale Gestaltungsfelder zur Förderung des Lernens in den verschiedenen Bereichen. Abschließend spricht der Artikel noch Schwierigkeiten und Probleme an sowie nimmt im Fazit ein perspektivischen Ausblick vor.

  6. NOTIZ USER EIN GNETUM VON BORNEO

    Directory of Open Access Journals (Sweden)

    Fr. Markgraf

    2015-11-01

    Full Text Available Diese Varietat, die ich friiher nach unvollstandigem Material zu G. diminutum gerechnet habe, besitzt in beiden Geschlechtern verzweigte Blutenstande. Dieses Merkmal kommt in der Gruppe mit sitzenden Fruch-ten (Subsection Sessiles nur bei G. leptostachyum, vor, zu dem auch die Friichte der neuen Varietat gut passen. Sie ist eine Nebelwaldpflanze grosserer Hohen und hat bei reduzierten Massen der Blatter und Bliitenstande die schmalen, kurzen mannlichen Katzchen der Tieflands-Varietat leptostachyum mit den kurzgliedrigen, grossfriichtigen weiblichen Bluten-standen der Tieflands-Varietat robustum vereinigt. In Indochina und Siam lebt eine zweite Berg-Varietat — entsprechend der weiteren Ent-fernung vom Aquator in etwas geringeren Hohen die umgekehrt die dicken mannlichen Katzchen von der Varietat robustum mit den lang-gliedrigen weiblichen Bliitenstanden von der Varietat leptostachyum vereinigt. In beiden Fallen sind die Verkiirzungs- und Verlangerungs-Tenden-zen bei den Berg-Varietaten starker als bei denen des Tieflandes.

  7. Evolution equations of von Karman type

    CERN Document Server

    Cherrier, Pascal

    2015-01-01

    In these notes we consider two kinds of nonlinear evolution problems of von Karman type on Euclidean spaces of arbitrary even dimension. Each of these problems consists of a system that results from the coupling of two highly nonlinear partial differential equations, one hyperbolic or parabolic and the other elliptic. These systems take their name from a formal analogy with the von Karman equations in the theory of elasticity in two dimensional space. We establish local (respectively global) results for strong (resp., weak) solutions of these problems and corresponding well-posedness results in the Hadamard sense. Results are found by obtaining regularity estimates on solutions which are limits of a suitable Galerkin approximation scheme. The book is intended as a pedagogical introduction to a number of meaningful application of classical methods in nonlinear Partial Differential Equations of Evolution. The material is self-contained and most proofs are given in full detail. The interested reader will gain a ...

  8. Metabolisierung von Lebensmittelinhaltsstoffen im simulierten Verdauungsmodell

    OpenAIRE

    Hageböck, Martin

    2013-01-01

    Mit Hilfe eines in vitro Modells, basierend auf 4 hintereinander geschalteten Bioreaktoren, war es möglich, komplexe Vorgänge der Verdauung modellhaft nachzustellen. Somit konnte die stufenweise Metabolisierung von ausgewählten Lebensmittelinhaltsstoffen unter definierten physikochemischen, enzymatischen und mikrobiellen Bedingungen der einzelnen Verdauungsstufen verfolgt werden. Beim Einsatz der polyphenolischen Reinsubstanzen wurden zunächst charakteristische Abbaureaktionen wie Hydrolyse v...

  9. La Medea de Lars von Trier

    Directory of Open Access Journals (Sweden)

    Iratxe Fresneda Delgado

    2013-04-01

    Full Text Available El presente artículo analiza el modo en el que Lars von Trier recrea para el cine el estereotipo de Medea. Mediante el análisis fílmico de la película y apoyándose en los estudios culturales, el texto se interroga acerca de la importancia y el poder potencial del cine a la hora recuperar el antiguo mito y demostrar su vigencia. El análisis amplía horizontes para la compresión de los mecanismos que articulan el entramado de significados de la película, donde Von Trier aporta una nueva visión del arquetipo de Medea uniéndola, a la tradición pictórica del Romanticismo. Una influencia que habita en las posteriores obras del director danés, donde el paisaje, la naturaleza, se erige en elemento catalizador de las pulsiones humanas, en su cómplice y testigo.This paper explores the way that Lars von Trier’s film recreates the stereotype of Medea. Using film analysis and based on cultural studies the article asks about the importance and potential power of cinema to recover the ancient myth and show their effects. The analysis expands horizons for the understanding of the mechanisms that link the network of meanings of the film, where the author offers a new vision of Medea's archetype attaching it to the pictorial tradition tied to the Romanticism. An influence that can be seen in the later works of Lars von Trier, where the landscape, the nature, stands as a catalyst of human drives, as his accomplice and witness.

  10. Diskretfrequente Synthese von Nachhall-Prozessen

    OpenAIRE

    Boesnecker, Robert

    2008-01-01

    Die Arbeit verfolgt einen neuartigen Ansatz zur digitalen Nachhallsynthese. Es wird dabei von folgender Beobachtung ausgegangen: Ruft man in ein Klavier, dessen Saiten unbedämpft sind, so antwortet das Instrument mit einem aus diskreten Einzeltönen bestehenden Nachklang, der ähnlich wie ein raumakustischer Nachhall klingt. Verbreitert man bei einer diskretfrequenten Synthese nun die spektrale Breite eines jeden "Klaviertons" auf einen schmalbandigen Bandpass, so dass nicht 12 Töne, sondern 12...

  11. Von Medien, Übertragungen und Automaten

    Directory of Open Access Journals (Sweden)

    Alessandro Barberi

    2013-12-01

    Full Text Available Im Zuge der Debatten zum Medialen Habitus wurde vielfach betont, dass die >Theorie der Praxispraxeologischen Medientheorie< des Medialen Habitus avant la lettre gesprochen werden kann. Dieser Artikel untersucht – ausgehend von den Debatten zur "Medienkompetenz" – wie Bourdieu Sprache, Sprechen und Diskurs, sowie Akteure, Felder und Habitus als Medien begreift und betont dabei die Nützlichkeit der Bourdieuschen Bildungssoziologie im Rahmen einer sozialwissenschaftlichen Grundlegung der Medienpädagogik.

  12. Bettina von Zwehl: Made up Love Song

    OpenAIRE

    Brown, Camilla

    2012-01-01

    This article considers an exhibition of work made whilst the artist Bettina von Zwehl was on a residency at the Victoria and Albert Museum London. Influenced by their miniature collection she made a new series of work and for the first time made one longer series of work with the same person. This essay considers how this development evolved from the artist's previous practice over a period of 10 years.

  13. Herstellung von Chitosan und einige Anwendungen

    Science.gov (United States)

    Struszczyk, Marcin Henryk

    2001-05-01

    1. Die Deacetylierung von crabshell - Chitosan führte gleichzeitig zu einem drastischen Abfall der mittleren viscosimetrischen Molmasse ( Mv), insbesondere wenn die Temperatur und die Konzentration an NaOH erhöht werden. Diese Parameter beeinflussten jedoch nicht den Grad der Deacetylierung (DD). Wichtig ist jedoch die Quelle des Ausgangsmaterials: Chitin aus Pandalus borealis ist ein guter Rohstoff für die Herstellung von Chitosan mit niedrigem DD und gleichzeitig hoher mittlerer Mv, während Krill-Chitin (Euphausia superba) ein gutes Ausgangsmaterial zur Herstellung von Chitosan mit hohem DD und niedrigem Mv ist. Chitosan, das aus Insekten (Calliphora erythrocephala), unter milden Bedingungen (Temperatur: 100°C, NaOH-Konzentration: 40 %, Zeit: 1-2h ) hergestellt wurde, hatte die gleichen Eigenschaften hinsichtlich DD und Mv wie das aus Krill hergestellte Chitosan. Der Bedarf an Zeit, Energie und NaOH ist für die Herstellung von Insekten-Chitosan geringer als für crabshell-Chitosan vergleichbare Resultaten für DD und Mv. 2. Chitosan wurde durch den Schimmelpilz Aspergillus fumigatus zu Chitooligomeren fermentiert. Die Ausbeute beträgt 25%. Die Chitooligomere wurden mit Hilfe von HPLC und MALDI-TOF-Massenspektrmetrie identifiziert. Die Fermentationsmischung fördert die Immunität von Pflanzen gegen Bakterien und Virusinfektion. Die Zunahme der Immunität schwankt jedoch je nach System Pflanze-Pathogen. Die Fermentation von Chitosan durch Aspergillus fumigatus könnte eine schnelle und billige Methode zur Herstellung von Chitooligomeren mit guter Reinheit und Ausbeute sein. Eine partiell aufgereinigte Fermentationsmischung dieser Art könnte in der Landwirtschaft als Pathogeninhibitor genutzt werden. Durch kontrollierte Fermentation, die Chitooligomere in definierter Zusammensetzung (d.h. definierter Verteilung des Depolymerisationsgrades) liefert, könnte man zu Mischungen kommen, die für die jeweilige Anwendung eine optimale Bioaktivität besitzen. 3

  14. Optimierung von Mehrkörpersystemen

    OpenAIRE

    Theis, Winfried; Räbiger, Klaus

    2009-01-01

    Auf Grund der ständig steigenden Anforderungen während der Entwicklung neuartiger Produkte ist es oftmals schwierig einen optimalen Entwurf zu finden. Die vorliegende Arbeit soll deshalb einen Einblick in die Welt der mathematischen Optimierung geben und anhand von ausgewählten Beispielen aus der Mehrkörperdynamik die nötigen Schritte einer Optimierungsrechnung genauer erklären. Spezielle Aufmerksamkeit wird hierbei der Ermittlung der Bewegungsgleichungen, der Formulierung der Optimierungsauf...

  15. Katheterablation von Vorhofflimmern - Neue Technologien und Strategien

    Directory of Open Access Journals (Sweden)

    Rolf S

    2011-01-01

    Full Text Available Die Katheterablation von symptomatischem Vorhofflimmern hat sich zu einem Therapieverfahren mit reproduzierbaren Erfolgsraten und überschaubarem Risiko bei selektierten Patientenkollektiven entwickelt. Hinsichtlich der Effektivität ist sie der Antiarrhythmika-Therapie schon heute überlegen. Die Verfahrenstechnik wird stetig weiterentwickelt, um die langfristige Erfolgsrate zu erhöhen, die Rate an Re-Interventionen zu reduzieren, die Komplikationsraten zu senken, die Prozedur selber zu vereinfachen und die Prozedurzeit zu verkürzen. Beispiele für solche Neuerungen sind die zielorientierte CT-Integration in elektro-anatomische Mappingsysteme, die optimierte Schaffung und Validierung linearer Läsionen mit der Pace-and-Ablate-Strategie, der effizientere Energietransfer ins Gewebe durch Verwendung steuerbarer transseptaler Schleusen und Berücksichtigung des elektrischen Kontaktes, sowie die strategische Planung von Linienkonzepten bei atrialen Makro-Reentry-Tachykardien durch Erstellung farbkodierter Entrainment- Maps. Diese Behandlungsinnovationen haben sich als wirkungsvoll erwiesen und in den vergangenen Jahren Einzug in den klinischen Alltag der Katheterablation von Vorhofflimmern im Herzzentrum Leipzig gefunde

  16. Geometric properties of the Kantowski-Sachs and Bianchi-type Killing algebra in relation to a Klein-Gordon equation

    Science.gov (United States)

    Jamal, Sameerah; Shabbir, Ghulam

    2017-02-01

    We study the geometric properties of generators for the Klein-Gordon equation in Kantowski-Sachs and certain Bianchi-type spaces. Several versions of the Klein-Gordon equation are derived from its dependence on a potential function. The criteria for different versions of the (1+3) Klein-Gordon equation originates from analyzing three sources, viz. through generators that are identically the Killing algebra, or with the Killing vector fields that are recast into linear combinations and thirdly, real sub-algebras within the conformal algebra. In turn, these equations admit a catalogue of infinitesimal symmetries that are equivalent to the corresponding Killing vector fields in Kantowski-Sachs, Bianchi type III, IX, VIII, VI0 and VII0 space-times, with the exception of a linear vector W=upartialu in every case. The sheer number of results are displayed in appropriate tables. Subsequently, in application, we derive some Noetherian conservation laws and identify some exact solutions by quadratures.

  17. A 3D mathematical model to predict spinal joint and hip joint force for trans-tibial amputees with different SACH foot pylon adjustments.

    Science.gov (United States)

    Yu, Chung-huang; Hung, Yu-Cheng; Lin, Yang-Hua; Chen, Guan-Xun; Wei, Shun-Hwa; Huang, Chang-Hung; Chen, Chen-Sheng

    2014-09-01

    A solid-ankle cushioned heel (SACH) foot is a non-joint foot without natural ankle function. Trans-tibial amputees may occur toe scuffing in the late swing phase due to a lack of active dorsiflexion. To address this problem, clinical guidelines suggests shortening the pylon to produce a smooth gait. However, this causes a leg length discrepancy, induces asymmetry in the hip joint, and causes an overload of L5/S1 joint force. Therefore, this study aimed to investigate the influence of different prosthesis pylons on the hip joint and L5/S1 joint forces. Ten subjects were recruited using leg length for normalisation. Four different pylon reductions (0%, 1%, 2%, and 3%) were used for gait analysis. A Vicon system and force plates were used to collect kinematic data and ground reaction force, respectively. The software package MATLAB was used to create a mathematical model for evaluating the symmetry and force of the hip joint and the low back force of the L5/S1 joint. The model was validated by the correlation coefficient (CC=0.947) and root mean square (RMS=0.028 BW). The model estimated that the 1% group had a symmetrical hip joint force and a lower L5/S1 joint force in the vertical direction. This study indicates that a 1% pylon shortening on a SACH prosthesis is appropriate for a trans-tibial amputee.

  18. 金融衍生品案例研究:高盛金融欺诈案%Case Study of Financial Derivatives: Fraud Action of Goldman Sachs

    Institute of Scientific and Technical Information of China (English)

    李欣婷; 闫妍; 薛欣

    2012-01-01

    The United States Securities and Exchange Commission brings the securities fraud action against Goldman Sachs, for making materially misleading statements and commissions in connection with a synthetic eollateralized debt obligation ("CDO") Goldman Sachs structured and marketed to investors. This CDO product whose name is ABACUS 2007-AC1 led to a great loss to the investors. This paper mainly analyzes the structures and risk features of three derivative products including RMBS, CDS and CDO. Based on the valuation formula, the reason of ABACUS 2007-AC1 depreciation is explained.%高盛集团因金融欺诈被美国证券交易委员会起诉,原因是高盛集团在销售一款合成担保债务凭证ABACUS2007-AC1时有误导性陈述,导致投资者巨额亏损。本文重点对案例中涉及的金融衍生品——RMBS、CDS和CDO的结构和风险特征进行分析,并结合CDO定价公式,对ABACUS2007-AC1的价值下跌进行定量的分析。

  19. The Influence of Arthroscopic Remplissage for Engaging Hill-Sachs Lesions Combined with Bankart Repair on Redislocation and Shoulder Function Compared with Bankart Repair Alone.

    Science.gov (United States)

    Ko, Sang-Hun; Cha, Jae-Ryong; Lee, Chae-Chil; Hwang, Il-Yeong; Choe, Chang-Gyu; Kim, Min-Seok

    2016-12-01

    Recurrence of glenohumeral dislocation after arthroscopic Bankart repair can be associated with a large osseous defect in the posterosuperior part of the humeral head. Our hypothesis is that remplissage is more effective to prevent recurrence of glenohumeral instability without a severe motion deficit. Engaging Hill-Sachs lesions were observed in 48 of 737 patients (6.5%). Twenty-four patients underwent arthroscopic Bankart repair combined with remplissage (group I) and the other 24 patients underwent arthroscopic Bankart repair alone (group II). Clinical outcomes were prospectively evaluated by assessing the range of motion. Complications, recurrence rates, and functional results were assessed utilizing the American Shoulder and Elbow Surgeons (ASES) score, Rowe score, and the Korean Shoulder Score for Instability (KSSI) score. Capsulotenodesis healing after remplissage was evaluated with magnetic resonance imaging. The average ASES, Rowe, and KSSI scores were statistically significantly higher in group I than group II. The frequency of recurrence was statistically significantly higher in group II. The average loss in external rotation measured with the arm positioned at the side of the trunk was greater in group II and that in abduction was also higher in group II. Compared to single arthroscopic Bankart repair, the remplissage procedure combined with arthroscopic Bankart repair was more effective to prevent the recurrence of anterior shoulder instability without significant impact on shoulder mobility in patients who had huge Hill-Sachs lesions.

  20. Engagement und Beanspruchung von Lehrpersonen in der Phase des Berufseintritts

    OpenAIRE

    Affolter-Huber, Benita Barbara

    2017-01-01

    Die Dissertation untersucht die Entstehung von Engagement und Beanspruchung von Lehrpersonen am Übergang von der Ausbildung in den Beruf. Das Job Demands-Resources Modell wird durch die Lern- und Vermeidungsleistungszielorientierung, die allgemeine Selbstwirksamkeits- sowie die Lehrerselbstwirksamkeitserwartung, die Extraversion und den Neurotizismus ergänzt und empirisch mittels Pfadanalysen geprüft. Aus den Befunden geht hervor, dass das Engagement und die Beanspruchung durch unterschiedlic...

  1. Studien zur Kinetik der Fehlfaltung un Aggregation von Proteinen

    OpenAIRE

    Modler, Andreas Johannes

    2003-01-01

    Diese Arbeit befasst sich mit der Kinetik der Fehlfaltung und Aggregation von Proteinen. Anhand dreier Beispiele, der Phosphoglyceratkinase (PGK) aus Hefe, einer Variante von Barstar und des Prion-Proteins des Syrischen Hamsters (SHaPrP(90-232)) wurde insbesondere die Kinetik der Bildung von Amyloidfibrillen und deren kinetischer Vorläuferstrukturen mittels dynamischer und statischer Lichtstreuung, Circulardichroismus, Infrarotspektroskopie, Elektronenmikroskopie und teilweise analytischer Ch...

  2. From regular modules to von Neumann regular rings via coordinatization

    Directory of Open Access Journals (Sweden)

    Leonard Daus

    2014-07-01

    Full Text Available In this paper we establish a very close link (in terms of von Neu- mann's coordinatization between regular modules introduced by Zel- manowitz, on one hand, and von Neumann regular rings, on the other hand: we prove that the lattice L^{fg}(M of all finitely generated submodules of a finitely generated regular module M, over an arbitrary ring, can be coordinatized as the lattice of all principal right ideals of some von Neumann regular ring S.

  3. Thomas-Fermi-von Weizsaecker theory of atoms and molecules

    Energy Technology Data Exchange (ETDEWEB)

    Benguria, R.; Brezis, H.; Lieb, E.H.

    1981-11-02

    We place the Thomas-Fermi-von Weizsaecker model of atoms on a firm mathematical footing. We prove existence and uniqueness of solutions of the Thomas-Fermi-von Weizsaecker equation as well as the fact that they minimize the Thomas-Fermi-von Weizsaecker energy functional. Moreover, we prove the existence of bindings for two very dissimilar atoms in the frame of this model.

  4. Portrait of Dr. Von Braun with Walt Disney, 1954.

    Science.gov (United States)

    1954-01-01

    Marshall Center Director Dr. Wernher Von Braun is pictured with Walt Disney during a visit to the Marshall Space Flight Center in 1954. In the 1950s, Dr. Von Braun while working in California on the Saturn project, also worked with Disney studios as a technical director in making three films about Space Exploration for television. Disney's tour of Marshall in 1965 was Von Braun's hope for a renewed public interest in the future of the Space Program at NASA.

  5. Saage tuttavaks : Elisabeth ja Karl von Hoerschelmann / Mai Levin

    Index Scriptorium Estoniae

    Levin, Mai, 1942-

    2004-01-01

    Kuraator M. Levin kuni 10. X 2004 Adamson-Ericu muuseumis avatud näitusest "Tuntud ja tundmatud Elisabeth von Rosendorff-Hoerschelmann ja Karl von Hoerschelmann". Enamik töid on kunstnike laste Konstantin Hoerschelmanni ja Anna Röder-Hoerschelmanni omand. Elisabeth Rosendorff (1898-1984) sündis Virumaal Maidlas eesti perekonnas, Karl von Hoerschelmann (1899-1951) Sevastoopolis saksa perekonnas

  6. Saage tuttavaks : Elisabeth ja Karl von Hoerschelmann / Mai Levin

    Index Scriptorium Estoniae

    Levin, Mai, 1942-

    2004-01-01

    Kuraator M. Levin kuni 10. X 2004 Adamson-Ericu muuseumis avatud näitusest "Tuntud ja tundmatud Elisabeth von Rosendorff-Hoerschelmann ja Karl von Hoerschelmann". Enamik töid on kunstnike laste Konstantin Hoerschelmanni ja Anna Röder-Hoerschelmanni omand. Elisabeth Rosendorff (1898-1984) sündis Virumaal Maidlas eesti perekonnas, Karl von Hoerschelmann (1899-1951) Sevastoopolis saksa perekonnas

  7. Sicherheitskriterien bei der Auswahl von ERP-Systemen

    OpenAIRE

    Wollersheim, Jan;Konstantinidis, Christos;Krcmar, Helmut

    2014-01-01

    Bei Auswahl und Anpassung von Software as a Service (SaaS) basierten ERP-Systemen (SaaS-ERP) kann auf bew?hrte und erprobte Kriterien zur?ckgegriffen werden. Dieser Beitrag strukturiert exemplarisch ausgew?hlte Sicherheits- und Risiko-Kriterien (S&R-Kriterien) anhand von f?nf Perspektiven. Dabei wird zuerst die Auswahl und im Folgenden die Anpassung von SaaS basierten ERP-Systemen betrachtet.

  8. Preiswettbewerb im deutschen Lebensmitteleinzelhandel: Empirische Analysen anhand von Scannerdaten

    OpenAIRE

    Hoffmann, Angela

    2012-01-01

    Der deutsche Lebensmitteinzelhandel ist durch eine hohe Konzentration und einen intensiven Preiswettbewerb gekennzeichnet. Ziel dieser Arbeit ist es, die Preissetzung von Discountern, Super- und Verbrauchermärkten unter Beachtung von Sonderangeboten und den daraus resultierenden Preiswettbewerb zu analysieren. Vier empirische Studien anhand von Scannerdaten werden durchgeführt. Es zeigt sich, dass das Ausmaß der Preissynchronisation bei Milchprodukten im deutschen Handel deutlich größer i...

  9. Photometric selection of emission-line galaxies, clustering analysis and a search for the integrated Sachs-Wolfe effect

    Science.gov (United States)

    Bielby, Rich; Shanks, T.; Sawangwit, U.; Croom, S. M.; Ross, Nicholas P.; Wake, D. A.

    2010-04-01

    We investigate the use of simple colour cuts applied to the Sloan Digital Sky Survey (SDSS) optical imaging to perform photometric selections of emission-line galaxies (ELGs) out to z S11). We thus perform colour cuts using the SDSS g, r and i bands and obtain mean photometric redshifts of and . We further calibrate our high-redshift selection using spectroscopic observations with the AAOmega spectrograph on the 4-m Anglo-Australian Telescope, observing ~50-200 galaxy candidates in four separate fields. With just 1h of integration time and seeing of ~ 1.6arcsec, we successfully determined redshifts for ~65 per cent of the targeted candidates. We compare our spectroscopic redshifts to the photometric redshifts from the COMBO-17 survey and find reasonable agreement between the two. We calculate the angular correlation functions of these samples and find correlation lengths of r0 = 2.78 +/- 0.08, 3.71 +/- 0.11 and 5.50 +/- 0.13h-1Mpc for the low-, mid- and high-redshift samples, respectively. Comparing these results with predicted dark matter clustering, we estimate the bias parameter for each sample to be b = 0.72 +/- 0.02, b = 0.93 +/- 0.03 and b = 1.43 +/- 0.03. We calculate the two-point redshift-space autocorrelation function at z ~ 0.6 and find a clustering amplitude of so = 6.4 +/- 0.8h-1Mpc. Finally, we use our photometric sample to search for the integrated Sachs-Wolfe signal in the Wilkinson Microwave Anisotropy Probe (WMAP) 5-yr data. We cross-correlate our three redshift samples with the WMAP W, V, Q and K bands and find an overall trend for a positive signal similar to that expected from models. However, the signal in each is relatively weak, with the results in the WMAP W band being wTg(<100arcmin) = 0.25 +/- 0.27, 0.17 +/- 0.20 and 0.17 +/- 0.16μK for the low-, mid- and high-redshift samples, respectively. Combining all three galaxy samples, we find a signal of wTg(<100arcmin) = 0.20 +/- 0.12μK in the WMAP W band, a significance of 1.7σ. However, in

  10. Specific mutations in the HEXA gene among Iraqi Jewish Tay-Sachs disease carriers: dating of founder ancestor.

    Science.gov (United States)

    Karpati, Mazal; Gazit, Ephraim; Goldman, Boleslaw; Frisch, Amos; Colombo, Roberto; Peleg, Leah

    2004-02-01

    The incidence of Tay-Sachs disease (TSD) carriers, as defined by enzyme assay, is 1:29 among Ashkenazi Jews and 1:110 among Moroccan Jews. An elevated carrier frequency of 1:140 was also observed in the Iraqi Jews (IJ), while in other Israeli populations the world's pan-ethnic frequency of approximately 1:280 has been found. Recently a novel mutation, G749T, has been reported in 38.7% of the IJ carriers (24/62). Here we report a second novel HEXA mutation specific to the IJ TDS carriers: a substitution of cytosine 1351 by guanosine (C1351G), resulting in the change of leucine to valine in position 451. This mutation was found in 33.9% (21/62) of the carriers and in none of 100 non-carrier IJ. In addition to the two specific mutations, 14.5% (9/62) of the IJ carriers bear a known "Jewish" mutation (Ashkenazi or Moroccan) and 11.3% (7/62) carry a known "non-Jewish" mutation. In 1 DNA sample no mutation has yet been detected. To investigate the genetic history of the IJ-specific mutations (C1351G and G749T), the allelic distribution of four polymorphic markers (D15S131, D15S1025, D15S981, D15S1050) was analyzed in IJ heterozygotes and ethnically matched controls. Based on linkage disequilibrium, recombination factor (theta) between the markers and mutated loci, and the population growth correction, we deduced that G749T occurred in a founder ancestor 44.8 +/- 14.2 generations (g) ago [95% confidence interval (CI) 17.0-72.6 g] and C1351G arose 80.4 +/- 35.9 g ago (95% CI 44.5-116.3 g). Thus, the estimated dates for introduction of mutations are: 626 +/- 426 A.D. (200-1052 A.D.) for G749T and 442 +/- 1077 B.C. (1519 B.C. to 635 A.D.) for C1351G.

  11. Solares Recyceln von Aluminium in einem direkt bestrahlten Drehrohrofen

    OpenAIRE

    Neises-von Puttkamer, Martina; Roeb, Martin; Beyer, T.; Reinhold, Jan Philipp; Willsch, Christian; Thelen, Martin; Raeder, Christian; Oliveira,Lamark de; TESCARI, Stefania; Breuer, Stefan; Sattler, Christian

    2016-01-01

    Das Aufschmelzen von Metallen ist ein energieintensiver Prozess, da hier hohe Temperaturen benötigt werden. Konventionell wird diese Energie mit fossilen Energieträgern zur Verfügung gestellt. Mit einem solaren Schmelzverfahren von Metallen können der Ausstoß von CO2 und die Energiekosten der Gießereien erheblich gesenkt werden. Insbesondere Länder mit hoher direkter Solarstrahlung wie Südafrika, können ein solches Verfahren zum Schmelzen und Wiederverwerten von Metallschrott einsetzten. ...

  12. Zielgerechte Logistikkonzepte in Betrachtung von LNG- Umschlageplätzen unter Berücksichtigung von Industrie 4.0

    OpenAIRE

    Jenne, Christian; Noche, Bernd

    2016-01-01

    Logistikkonzepte in der Spedition und Transportgewerbe spielen heutzutage eine immer wichtigere Rolle, um Lohnnebenkosten so niedrig wie möglich zu halten. Gerade in der Spedition entsteht ein Zusammenspiel aus zeitnaher Lieferung von Konsumgütern und Optimierung der Lagerhaltungskosten bei dem die modulare Integration von Logistik, Informationstechnischen Systemen und vernetzter Kommunikation eine ganz spezifische Rolle hat. Anbindung von der Industrie zum Kunden wird dadurch immer mehr vers...

  13. WIE PREISSENSIBEL REAGIEREN DEUTSCHE VERBRAUCHER? AKTUELLE SCHÄTZUNGEN VON PREIS- UND AUSGABENELASTIZITÄTEN AUF DER BASIS VON HAUSHALTSPANELDATEN

    OpenAIRE

    2012-01-01

    Der Beitrag untersucht das Nachfrageverhalten der deutschen Privathaushalte anhand von Daten zweier Haushaltspanels der Gesellschaft für Konsumforschung. Es wird ein Almost Ideal Demand System (AIDS) mit 13 Lebensmittelgruppen für den Zeitraum von 2004 bis 2008 geschätzt. Der Fokus der Analyse liegt auf den geschätzten Eigenpreis- und Ausga-benelastizitäten und deren Einordnung in die Literatur. Mit Ausnahme von Kaffee und Eiern zeigt sich die Nachfrage in allen Lebensmittelgruppen, darunter ...

  14. Produktion von pharmakologischen Sekundärmetabolite - Am Beispiel von mikrobiellen β-Lactam-Antibiotika und pflanzlichen Triterpenen

    OpenAIRE

    Ludwig, Benjamin

    2015-01-01

    Durch das Entstehen von neuen Infektionskrankheiten und das Auftreten von Resistenzen können bisher verwendete Medikamente ihren pharmazeutischen Nutzen verlieren. Daher ist eine konstante Weiterentwicklung von bioaktiven Pharmazeutika lebensrettend. Viele pflanzli-che und mikrobielle Sekundärmetabolite besitzen gesundheitsfördernde Wirkungen und kön-nen als Ressourcen für die Entwicklung neuer Arzneimittel herangezogen werden. Da Pflan-zen und Mikroorganismen ein sehr umfangreiches Repertoir...

  15. Assoziation des arteriellen Sauerstoffpartialdrucks mit dem Auftreten von Erythroblasten im peripheren Blut von Patienten einer chirurgischen Intensivstation

    OpenAIRE

    Kuert, Sandra

    2012-01-01

    Erythroblasten (EBL) treten im peripheren Blut eines gesunden Erwachsenen gewöhnlich nicht auf. Studien zeigten, dass das Auftreten von EBL bei hospitalisierten Patienten auf ein erhöhtes Mortalitätsrisiko hinweist. Die zugrundeliegenden Mechanismen sind bisher unbekannt. Es ergaben sich Hinweise, dass EBL bei Zuständen von Hypoxie und Inflammation auftreten. Die vorliegende Studie untersucht den Einfluss des arteriellen Sauerstoffpartialdruckes (pO2) auf das Auftreten von EBL ...

  16. Philologie im Horizont der Geschichtlichkeit von Sprache und Text: zum Tagungsband von Wulf Oesterreicher und Maria Selig

    Directory of Open Access Journals (Sweden)

    Olaf Müller

    2016-03-01

    Full Text Available Wulf Oesterreicher und Maria Selig, Hrsg., Geschichtlichkeit von Sprache und Text: Philologien – Disziplingenese – Wissenschaftshistoriographie (Paderborn: Wilhelm Fink, 2014, 332 S.

  17. Unterschiedliche beta-blockierende Wirkungen von Carvedilol, Metoprolol und Bisoprolol

    Directory of Open Access Journals (Sweden)

    Stoschitzky K

    2001-01-01

    Full Text Available Metoprolol und Bisoprolol sind beta1-selektive Beta-Blocker, Carvedilol ist ein nicht-selektiver Beta-Blocker mit zusätzlicher alpha1-blockierender Wirkung. Wir verglichen die Wirkungen von klinisch empfohlenen Dosen von Carvedilol (25, 50 und 100 mg, Metoprolol (50, 100 und 200 mg und Bisoprolol (2,5, 5 und 10 mg mit Placebo in einer randomisierten, überkreuzten, placebokontrollierten Doppelblind-Studie an 12 gesunden männlichen Freiwilligen. Zwei Stunden (Bisoprolol: drei Stunden nach oraler Applikation der jeweiligen Substanzen wurden arterieller Blutdruck und Herzfrequenz in Ruhe, nach 10 Minuten Belastung und nach weiteren 15 Minuten Erholung gemessen. Verglichen mit Placebo führten ansteigende Dosen von Metoprolol und Bisoprolol in Ruhe zu ansteigenden Wirkungen auf die Herzfrequenz (jeweils -13 %, -15 % und -18 % während ansteigende Dosen von Carvedilol abfallende Wirkungen zeigten (-13 %, -7 % und -3 %. Die Herzfrequenz unter Belastung wurde von Metoprolol (-21 %, -25 % und -24 %, Bisoprolol (-17 %, -21 % und -25 % und Carvedilol gesenkt (-16 %, -16 % und -18 %, die Wirkung von Metoprolol erschien dabei etwas ausgeprägter als jene von Carvedilol. Der systolische Blutdruck wurde sowohl von Metoprolol (-9 %, -16 %, -16 % unter Belastung und -7 %, -7 %, -9 % nach 15 min Erholung, Bisoprolol (-8 %, -12 %, -15 % unter Belastung als auch von Carvedilol (-7 %, -17 %, -20 % unter Belastung und -8 %, -11 %, -14 % nach 15 min Erholung deutlich gesenkt. Auf den diastolischen Blutdruck zeigten die Substanzen (mit Ausnahme von 50 und 100 mg Carvedilol in Ruhe jedoch keine signifikanten Wirkungen. Wir schließen aus unseren Ergebnissen, daß klinisch empfohlene Dosen von Carvedilol bei gesunden Freiwilligen klinisch relevante beta-blockierende Wirkungen nur unter Belastung zeigen, während die von Carvedilol bewirkte Beta-Blockade in Ruhe bestenfalls als schwach zu bezeichnen ist. Auf der anderen Seite zeigen Metoprolol und Bisoprolol sowohl in

  18. Von den Liven von Oesel / August Ludwig Schlözer

    Index Scriptorium Estoniae

    Schlözer, August Ludwig

    2008-01-01

    Avaldatud Eberhard Winkleri initsiatiivil A. L. Schlözeri teose põhjal: Gesammelte Nachrichten von den Ueberresten der Liven, in Livland und Kurland. (1770), mis moodustab osa teosest: Schlözer, August Ludwig. M. Johann Joseph Haigold's Beylagen zum Neuveränderten Russland. Zweiter Theil. Riga und Leipzig, 1770

  19. Ööklubi Club von Überlingen = Club von Überlingen

    Index Scriptorium Estoniae

    2008-01-01

    Ööklubi Club von Überlingen (Madara 22A, Tallinn) sisekujundusest. Sisearhitekt: Taavi Aunre (Boom.ee OÜ). Taavi Aunrest, tema tähtsamad tööd. I-II korruse plaan, 11 värv. vaadet, foto T. Aunrest

  20. Aino Lepik von Wiren / Aino Lepik von Wiren ; interv. Kadi Alatalu

    Index Scriptorium Estoniae

    Lepik von Wirén, Aino, 1961-

    2007-01-01

    Heinrich Marga eksiilvalitsuse (20.06.1990-7.10.1992) kohtuminister Aino Lepik von Wiren pagulaslapse elust Rootsis, haridusest ja elukutse valikust, tööst eksiilvalitsuses, tööleasumisest Eestisse 1992. aastal, seadusandlikust tegevusest ning aluse panekust välismaalaste- ja kodakondsuspoliitikale, naiste võimalustest poliitilisse tippu tõusmiseks, kodu- ja väliseestlaste vastandamisest

  1. Von den Liven von Oesel / August Ludwig Schlözer

    Index Scriptorium Estoniae

    Schlözer, August Ludwig

    2008-01-01

    Avaldatud Eberhard Winkleri initsiatiivil A. L. Schlözeri teose põhjal: Gesammelte Nachrichten von den Ueberresten der Liven, in Livland und Kurland. (1770), mis moodustab osa teosest: Schlözer, August Ludwig. M. Johann Joseph Haigold's Beylagen zum Neuveränderten Russland. Zweiter Theil. Riga und Leipzig, 1770

  2. Die Felsfassadengräber von Kyrene

    OpenAIRE

    Greve, Anika

    2006-01-01

    Die griechische Kolonie Kyrene wurde im letzten Drittel des 7. Jhs. v. Chr. einige Kilometer vom Mittelmeer entfernt im libyschen Innenland gegründet. Die Siedler waren dorische Griechen aus Thera im Süden der Kykladen. Nicht nur die erhaltenen innerstädtischen Gebäude zeugen von einem einstigen Wohlstand, auch die Nekropole nahm im Laufe der Zeit gewaltige Ausmaße mit aufwendig gestalteten Grabanlagen an, die sich rund um die urbane Bebauung entlang der Ausfallstraßen ausbreitete. Viele Ruhe...

  3. Authentifizierung von Bio-Milch im Labor

    OpenAIRE

    2008-01-01

    In Deutschland ist die Nachfrage nach Bio-Lebensmitteln in den letzten Jahren stetig gestiegen. So erhöhte sich der Absatz von Bio-Trinkmilch in 2007 im Vergleich zum Vorjahr erneut kräftig um 34 Prozent (ZMP, Bonn) und der Bio-Anteil beträgt inzwischen bei Frischmilch knapp elf Prozent. Aufgrund sporadisch resultierender Lieferengpässe bei Bio-Milch sowie der vorhandenen Handelspreisdifferenz besteht zunehmend ein potenzielles Risiko der Falschdeklaration konventionell erzeugter Milch als Bi...

  4. Key contributors: Ernst von Glasersfeld's radical constructivism

    Science.gov (United States)

    Tobin, Kenneth

    2007-07-01

    This article reviews the significance of the contributions of Ernst von Glasersfeld to research in science education, especially through his theoretical contributions on radical constructivism. As a field shaper, Glasersfeld's subversive ideas catalyzed debate in the science education community and fuelled transformation of many facets including research methods, ways of thinking about teaching and learning, curriculum, and science teacher education. Perturbations emanating from the debates on constructivism forged new pathways that led to the development and use of many of the sociocultural frameworks employed by authors in Cultural Studies of Science Education.

  5. Synthese und Applikation von magnetisch verformbaren Hydrogelkompositen

    OpenAIRE

    Bolle, Jens

    2011-01-01

    Als „intelligent“ bezeichnete Materialien sind in der Lage, mit steuerbaren Form- oder Eigenschaftsänderungen auf Zielreize zu reagieren, ohne dafür einen zusätzlichen Sensor zu benötigen. Man bezeichnet sie daher auch als Sensor-Aktor-Systeme. Da sie ohne äußere Sensorsysteme auskommen, können diese Werkstoffe als kleine, einfach anwendbare und preisgünstige Bauteile für eine Vielzahl von Applikationen dienen. Ihre Entwicklung gestattet sowohl die fortschreitende Miniaturisierung tech-nische...

  6. Von Krahli Teater hakkab koolitama näitlejaid

    Index Scriptorium Estoniae

    2007-01-01

    Von Krahli Teater hakkab osalema järgmisel sügisel TÜ Viljandi Kultuuriakadeemia teatrikunsti erialale õppima asuvate tudengite koolitamises. Tudengeid hakkavad juhendama Von Krahli juht Peeter Jalakas, näitlejad Taavi Eelmaa ja Juhan Ulfsak, vene tantsija ja koreograaf Sasha Pepeljajev ning soome lavastaja Kristian Smeds

  7. On the miscellaneous aspects of von Willebrand factor

    NARCIS (Netherlands)

    Groeneveld, Dafna Jordana

    2015-01-01

    Von Willebrand disease is the most common inherited bleeding disorder and is characterized by reduced plasma von Willebrand factor (VWF) levels or functionally abnormal VWF. VWF is best known for its three classical hemostatic functions: (i) as a carrier protein for coagulation factor VIII, (ii)

  8. von Willebrand disease and aging : an evolving phenotype

    NARCIS (Netherlands)

    Sanders, Y. V.; Giezenaar, M. A.; Laros-van Gorkom, B. A. P.; Meijer, K.; van der Bom, J. G.; Cnossen, M. H.; Nijziel, M. R.; Ypma, P. F.; Fijnvandraat, K.; Eikenboom, J.; Mauser-Bunschoten, E. P.; Leebeek, F. W. G.

    2014-01-01

    Background: Because the number of elderly von Willebrand disease (VWD) patients is increasing, the pathophysiology of aging in VWD has become increasingly relevant. Objectives: To assess age-related changes in von Willebrand factor (VWF) and factor VIII (FVIII) levels and to compare age-related diff

  9. Von Krahli teatris etenduvad Tõnu Kõrvitsa kammerooperid / Esme Kassak

    Index Scriptorium Estoniae

    Kassak, Esme

    2006-01-01

    20. apr. esietenduvad Von Krahli Teatris Peeter Jalaka lavastuses Tõnu Kõrvitsa uued kammerooperid "Tuleaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libretode autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  10. Von Krahli teater mängib Kõrvitsa kammeroopereid

    Index Scriptorium Estoniae

    2006-01-01

    20. apr. esietenduvad Von Krahli Teatris Peeter Jalaka lavastuses Tõnu Kõrvitsa uued kammerooperid "Tuleaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libretode autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  11. Von Krahli teatris etenduvad Tõnu Kõrvitsa kammerooperid / Esme Kassak

    Index Scriptorium Estoniae

    Kassak, Esme

    2006-01-01

    20. apr. esietenduvad Von Krahli Teatris Peeter Jalaka lavastuses Tõnu Kõrvitsa uued kammerooperid "Tuleaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libretode autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  12. Victor or Villain? Wernher von Braun and the Space Race

    Science.gov (United States)

    O'Brien, Jason L.; Sears, Christine E.

    2011-01-01

    Set during the Cold War and space race, this historical role-play focuses on Wernher von Braun's involvement in and culpability for the use of slave laborers to produce V-2 rockets for Nazi Germany. Students will grapple with two central questions. Should von Braun have been allowed to emigrate to the United States given his affiliation with the…

  13. Die baltischen Kapitulationen von 1710 : Kontext, Wirkungen, Interpretationen / Marten Seppel

    Index Scriptorium Estoniae

    Seppel, Marten, 1979-

    2015-01-01

    Arvustus: Die baltischen Kapitulationen von 1710 : Kontext, Wirkungen, Interpretationen, hrsg. von Karsten Brüggemann, Mati Laur und Pärtel Piirimäe, Queleln und Studien zur baltischen Geschichte, Bd 23 (Köln u.a: Böhlau Verlag, 2014)

  14. Von Krahli teater mängib Kõrvitsa kammeroopereid

    Index Scriptorium Estoniae

    2006-01-01

    20. apr. esietenduvad Von Krahli Teatris Peeter Jalaka lavastuses Tõnu Kõrvitsa uued kammerooperid "Tuleaed" ja "Mu luiged, mu mõtted", mille aluseks on luuletaja Marie Heibergi saatus. Libretode autor on Maarja Kangro. Kammerooperid tulevad lavale Von Krahli Teatri ja Nargen Opera koostöös. Esitavad Kädy Plaas, Helen Lokuta, Nargen Opera koor ja Tallinna Kammerorkester, dirigent Tõnu Kaljuste

  15. Diurnal variation of von Willebrand factor in plasma

    DEFF Research Database (Denmark)

    Timm, Annette; Fahrenkrug, Jan; Jørgensen, Henrik L;

    2014-01-01

    BACKGROUND: Quantitation of von Willebrand factor (VWF) in plasma is a central element in assessing von Willebrand disease (VWD). VWF activity is known to vary, which has partly been ascribed to biological and preanalytical variation. However, a possible diurnal expression of VWF has not been tho...

  16. Entwicklung eines amperometrischen Biosensors zur Erfassung von Polyphenolen

    OpenAIRE

    2013-01-01

    In der durchgeführten Arbeit wurden neue Immobilisierungsstrategien zur Etablierung eines amperometrischen Biosensors, welcher Polyphenole erfasst, untersucht. Ziel war es eine „Handheld-Unit“ unter Verwendung einer Dickschichtelektrode (Thick-Film Technology, TFT) zu entwickeln. Zur Erfassung von Polyphenolen wurde das Enzym Laccase ausgewählt, welche die Oxidation von Phenolen zu Chinonen katalysiert. Dabei wurden in dieser Arbe...

  17. Von Stryk : halb oli nii aadlikel kui talupoegadel / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2007-01-01

    Rets. rmt.: Stryk, Wolf Dietmar von. Morsel-Podrigel, das Stammhaus der familie von Stryk in Livland/Estland 1562-1919-2003. : die Geschichte eines Gutes im Wandel der Zeiten der Jahrhunderte bis zur Gegenwart. Viljandi : W. Stryk, 2006. Artikkel ilmunud ka: Valgamaalane, 3. märts 2007, lk 4

  18. Erfahrungen an der Schnittstelle von Medienarbeit und Praxisforschung

    Directory of Open Access Journals (Sweden)

    Peter Holzwarth

    2007-11-01

    Full Text Available Der Beitrag reflektiert die Verbindung von praktischer Medienarbeit und Forschung am Beispiel eines internationalen EU-Forschungsprojekts zum Thema Medien und Migration. Neben didaktischen Prinzipien und Konzepten für die aktive Medienarbeit im Forschungskontext geht es um die Kooperation von medienpädagogischer Begleitung (MB und wissenschaftlicher Begleitung (WB sowie um deren spezifische Kompetenzen.

  19. Auf den Schultern von Riesen und Zwergen Einsteins unvollendete Revolution

    CERN Document Server

    Renn, Jürgen

    2006-01-01

    Dies ist die Geschichte von Einsteins unvollendeter Revolution, einer tiefgreifenden Veränderung unserer Begriffe von Raum, Zeit, Materie und Strahlung. Diese Revolution begann in Einsteins Wunderjahr 1905, wurde durch seine allgemeine Relativitätstheorie aus dem Jahre 1915 fortgesetzt und wirkt in den heutigen Versuchen der Wissenschaft, die Entstehung und das Schicksal des Universums zu verstehen, weiter. Vor dem Hintergrund einer historischen Theorie des wissenschaftlichen Fortschritts wird Einsteins bis heute nicht abgeschlossene Revolution als das Ergebnis einer langfristigen Entwicklung des Wissens verständlich. Anhand der spannenden Geschichte von Einsteins Entdeckungen wird nachvollziehbar, warum große Denker wie Einstein weiter gesehen haben als ihre Vorgänger. Sie standen nicht nur auf den Schultern von Riesen, also den wissenschaftlichen Leistungen einzelner großer Vorgänger wie Newton, sondern auch auf den Schultern von "Zwergen", dem wissenschaftlichen Wissen, dem technischen Wissen, und d...

  20. Tay-Sachs Disease

    Science.gov (United States)

    ... Craniosynostosis Information Page Creutzfeldt-Jakob Disease Information Page Cushing's Syndrome Information Page Dandy-Walker Syndrome Information Page Deep Brain Stimulation for Parkinson's Disease Information Page Dementia Information ...

  1. Tay-Sachs Disease

    Science.gov (United States)

    ... continue Prenatal Diagnosis Pregnant women can have their unborn babies tested for the HEXA deficit that causes ... child may have seizures and become completely disabled. Death usually occurs by the time the child is ...

  2. Tay-Sachs disease

    Science.gov (United States)

    ... MF, eds. Creasy and Resnik's Maternal-Fetal Medicine: Principles and Practice . 7th ed. Philadelphia, PA: Elsevier Saunders; 2014:chap 30. Review Date 10/30/2016 Updated by: Anna C. Edens Hurst, MD, MS, Assistant Professor in Medical Genetics, The University of Alabama at Birmingham, Birmingham, AL. ...

  3. Molecular analysis of the HEXA gene in Italian patients with infantile and late onset Tay-Sachs disease: detection of fourteen novel alleles.

    Science.gov (United States)

    Montalvo, Anna Lisa E; Filocamo, Mirella; Vlahovicek, Kristian; Dardis, Andrea; Lualdi, Susanna; Corsolini, Fabio; Bembi, Bruno; Pittis, Maria Gabriela

    2005-09-01

    Tay-Sachs disease (TSD) is a recessively inherited disorder caused by the hexosaminidase A deficiency. We report the molecular characterization performed on 31 Italian patients, 22 with the infantile, acute form of TSD and nine patients with the subacute juvenile form, biochemically classified as B1 Variant. Of the 29 different alleles identified, fourteen were due to 15 novel mutations, two being in-cis on a new complex allele. The new alleles caused four frameshifts, three premature stop codons, three amino acid changes, two amino acid deletions and two splicing alterations. As previously reported, the c.533G>A (p.R178H) mutation was present either in homozygosity or as compound heterozygote, in all the patients with the late onset TSD form (B1 Variant); the allele frequency in this group is discussed by comparison with that found in infantile TSD.

  4. Accelerated expansion of the universe and chasing photons from the CMB to study the late time integrated Sachs-Wolfe effect over different redshift ranges

    CERN Document Server

    Rahman, Syed Faisal ur

    2016-01-01

    In this study, we are going to discuss the accelerated expansion of the universe and how this accelerated expansion affects the paths of photons from cosmic microwave background radiation (CMB). Then we will see how wide-field galaxy surveys along with cosmic CMB anisotropy maps can help us in studying dark energy. The cross-correlation of galaxy over/under-density maps with CMB anisotropy maps help us in measuring one of the most useful signatures of dark energy i.e. Integrated Sachs-Wolfe (ISW) effect. ISW effect explains the blue-shifting and red-shifting of CMB photons when they reach to us after passing through large scale structures and super-voids respectively. We will look into the theoretical foundations behind ISW effect and discuss how modern all sky galaxy surveys like EMU-ASKAP will be useful in studying the effect.

  5. Finite element analysis as a tool for parametric prosthetic foot design and evaluation. Technique development in the solid ankle cushioned heel (SACH) foot.

    Science.gov (United States)

    Saunders, Marnie M; Schwentker, Edwards P; Kay, David B; Bennett, Gordon; Jacobs, Christopher R; Verstraete, Mary C; Njus, Glen O

    2003-02-01

    In this study, we developed an approach for prosthetic foot design incorporating motion analysis, mechanical testing and computer analysis. Using computer modeling and finite element analysis, a three-dimensional (3D), numerical foot model of the solid ankle cushioned heel (SACH) foot was constructed and analyzed based upon loading conditions obtained from the gait analysis of an amputee and validated experimentally using mechanical testing. The model was then used to address effects of viscoelastic heel performance numerically. This is just one example of the type of parametric analysis and design enabled by this approach. More importantly, by incorporating the unique gait characteristics of the amputee, these parametric analyses may lead to prosthetic feet more appropriately representing a particular user's needs, comfort and activity level.

  6. Suitability of tracers; Eignung von Tracern

    Energy Technology Data Exchange (ETDEWEB)

    Klotz, D. [GSF - Forschungszentrum fuer Umwelt und Gesundheit GmbH, Neuherberg (Germany). Inst. fuer Hydrologie

    1999-02-01

    Hydrological tracer techniques are a means of making statements on the direction and speed of underground water. One of the simpler tasks is to find out whether there is hydrological communication between two given points. This requires a determination of the direction of flow, which places less exacting demands on the properties of the tracer than does the task of determining the flow velocity of underground water. Tracer methods can serve to infer from flow velocity the distance (flow) velocity, which is defined as the ratio between the distance between two points located in flow direction and the actual time it takes water to flow from one to the other. [Deutsch] Mit Hilfe der hydrologischen Markierungstechniken koennen Aussagen ueber die Richtung und die Geschwindigkeit von Bewegungen des unterirdischen Wassers gemacht werden. Der einfachere Fall liegt vor, wenn festgestellt werden soll, ob zwischen zwei Punkten eine hydrologische Verbindung besteht. Bei dieser Fliessrichtungsbestimmung sind die Forderungen an die Eigenschaften der einzusetzenden Tracer geringer als bei der Bestimmung der Geschwindigkeit des unterirdischen Wassers. Von den Geschwindigkeiten des unterirdischen Wassers ist die Abstands-(Fliess)geschwindigkeit, die definiert ist durch das Verhaeltnis aus dem Abstand und der wahren Fliesszeit zwischen zwei in Bewegungsrichtung gelegenen Punkten, durch Tracermethoden zu bestimmen. (orig.)

  7. Guy von Dardel 1919-2009

    CERN Multimedia

    2009-01-01

    Guy von Dardel, a well-known figure at CERN and in the international particle physics community, passed away on 28 August. Guy von Dardel came to CERN when it was founded in 1954 and was a full-time staff member until 1964, performing several experiments and working on technical developments. These included the first measurement of the neutral pion’s life-time. Called to Lund University in 1964, he became professor there in 1965 and director of the 1.2 GeV electron accelerator. In the late 1960s, he performed an experiment at CERN’s PS that measured the decays of the Λ. Then, in the early 1970s, he involved the Lund group in a series of experiments at the Intersecting Storage Rings (ISR), where he measured the production of various types of particles. In particular, he participated in a series of experiments that observed the production of a high abundance of particles with large transverse momenta. This required an explanation...

  8. Approximate von Neumann entropy for directed graphs.

    Science.gov (United States)

    Ye, Cheng; Wilson, Richard C; Comin, César H; Costa, Luciano da F; Hancock, Edwin R

    2014-05-01

    In this paper, we develop an entropy measure for assessing the structural complexity of directed graphs. Although there are many existing alternative measures for quantifying the structural properties of undirected graphs, there are relatively few corresponding measures for directed graphs. To fill this gap in the literature, we explore an alternative technique that is applicable to directed graphs. We commence by using Chung's generalization of the Laplacian of a directed graph to extend the computation of von Neumann entropy from undirected to directed graphs. We provide a simplified form of the entropy which can be expressed in terms of simple node in-degree and out-degree statistics. Moreover, we find approximate forms of the von Neumann entropy that apply to both weakly and strongly directed graphs, and that can be used to characterize network structure. We illustrate the usefulness of these simplified entropy forms defined in this paper on both artificial and real-world data sets, including structures from protein databases and high energy physics theory citation networks.

  9. Kontextualisierung von Queer Theory Contextualizing Queer Theory

    Directory of Open Access Journals (Sweden)

    Anna Voigt

    2008-03-01

    Full Text Available Christine M. Klapeer legt in diesem Einführungsband dar, aus welchen politischen und theoretischen Kontexten heraus sich ‚queer‘ zu einem Begriff mit besonderem politischem und theoretischem Gehalt entwickelt hat. Wesentlich zielt sie dabei auf eine kritische Kontextualisierung von „queer theory”. Die Autorin geht zunächst auf das Gay Liberation Movement ein, grenzt die Queer Theory vom Poststrukturalismus, von feministischen Theorien und den Lesbian and Gay Studies ab, beleuchtet Eckpunkte queeren Denkens und zeichnet schließlich die Entwicklungen in Österreich sowohl politisch-rechtlich als auch bewegungsgeschichtlich und in der Wissenschaftslandschaft nach.Christine M. Klapeer’s introductory volume demonstrates the manner in which ‘queer’ grew out of various political and theoretical contexts to become a term with special political and theoretical content. She focuses primarily on a critical contextualization of “queer theory.” The author begins by approaching the Gay Liberation Movement and then distinguishes Queer Theory from poststructuralism, from feminist theories, and from Lesbian and Gay Studies. She continues on to illuminate the key aspects of queer thought and concludes by sketching the development in Austria in terms of politics and the law, the history of movements, and within the landscape of knowledge.

  10. Integrales Lernen in und von Organisationen

    Directory of Open Access Journals (Sweden)

    Wendelin Küpers

    2006-06-01

    Full Text Available Bezogen auf das integrale Models von Ken Wilber untersucht der Beitrag die Bedeutung des Lernens in und von Organisationen. Nach einer Darstellung der Relevanz und des Grundverständnisses des Lernens im Organisationskontext, werden integrale Dimensionen des Lernens dargestellt. Im Einzelnen werden die verschiedenen Sphären eines inneren-subjektiven und äusseren-„objektiven“ Lernens des Einzelnen als auch ein gemeinschaftliches Lernen und Lernen im System auf der kollektiven Ebene dargestellt sowie deren interrelationaler Zusammenhang diskutiert. Schließlich beschreibt der Beitrag noch integrale Lernprozesse sowie integrale Gestaltungsfelder zur Förderung des Lernens in den verschiedenen Bereichen. Abschließend spricht der Artikel noch Schwierigkeiten und Probleme an sowie nimmt im Fazit ein perspektivischen Ausblick vor. Abstract: Related to the integral model of Ken Wilber, this paper investigates the role of learning in and of organisations. After describing the relevance and basic understanding of learning in the context of organisations, integral dimensions of learning will be outlined. In particular learning in the sphere of an inner-subjective and exterior-objective learning of the individual and a communal learning and learning within a system on the collective level as well as its interrelations will be discussed. Afterwards integral learning processes and various measurements for enhancing integral learning in the different sphere will be discussed. Finally, difficulties and problems will be addressed and in conclusion some perspectives and implications are presented.

  11. Katheterablation von supraventrikulären Tachykardien

    Directory of Open Access Journals (Sweden)

    Strohmer S

    2011-01-01

    Full Text Available Supraventrikuläre Tachykardien (SVT spielen in der klinischen Praxis aufgrund ihrer Häufigkeit und Symptomatik eine große Rolle. Obwohl diese Arrhythmien im Allgemeinen nicht lebensbedrohlich sind, führen sie aufgrund ihres unvorhersehbaren Auftretens zu einer beträchtlichen Unsicherheit und Einschränkung der Lebensqualität. Die elektrophysiologische Untersuchung inklusive Katheterablation hat sich in den vergangenen 20 Jahren als kurative und sichere Erstlinientherapie für Patienten mit hochsymptomatischen bzw. wiederholten Anfällen etabliert. Heutzutage liegen die Erfolgsraten für die Radiofrequenzablation der regulären SVT über 95 % bei einer sehr niedrigen Rezidivrate von weniger als 5 %. Eine antiarrhythmische Therapie für das Langzeitmanagement ist aufgrund der geringen Effektivität und Gefahr von ernsthaften Nebenwirkungen weitgehend obsolet und nur in Ausnahmefällen erforderlich. Der folgende Artikel gibt eine aktuelle Übersicht über die häufigsten rhythmischen Schmalkomplextachykardien, die verschiedenen Mechanismen und moderne nicht-pharmakologische Therapieansätze.

  12. Die Krakauer Kirche von Karmeliten und Karmelitaninnen

    Directory of Open Access Journals (Sweden)

    Józef Szymon Wronski

    2004-12-01

    Full Text Available 1. Die Klosterkirche der unbeschuhten Karmelitinnen Zum Heiligen Josef. Ein glücklicher Auftakt und somit die charakteristische Einführung in das 20. Jh. für den Kirchenbau von Krakau war die Errichtung der Karmeliterinnen St. Josephs-Kirche an der Lobzowska-Straße 40, in der die Architekten (Tadeusz Stryjeński (1849-1943 - Projektant der Kirche und Franciszek Mączyński (1874-1947 - Ausführer des Bauprojektes mit eigenen Verbesserungen die historisch- eklektizistischen Formen d.h. die mittelalterlichen Formen vor allem des sog. Übergangsstils vereinfachten. Die Kirche, die in den Jahren 1903-1905 errichtet wurde, steht inmitten vom Baukomplex des Klosters, dessen Grundriss das Quadrat ist49. Der Kirchenbau ist ein dem Gesamtbau des Klosters eingefügter Längsraum. Hinter dem Chor liegt das Oratorium des Konvents. Das Material Backstein (mit Verwendung von Stein erinnert an die Baukunst eines der besten Architekten jener Zeit, nämlich Teodor Talowskis (1857-1910, der viele Kirchen in Südpolen, aber auch viele Bürgerhäuser nicht nur in Krakau im ausgehenden 19. Jh. baute. Die Architektur der Karmeliterinnen St. Josephs-Kirche ist immer noch im Malerischen begriffen. Aber die Vereinfachung der historischen Formen führt zu ihrer „Beruhigung” und dadurch zur Wuchtigkeit des Ausdrucks. Bemerkenswert ist die in dieser Zeit (in der Anlage noch seltene ausgewogene Proportionierung des Baukörpers. Das methodische Prinzip jener Zeit ist der Kontrast. Im Kontrast zu den gedrungenen und wuchtigen Formen des Baukörpers stehen z.B. die sich verjüngenden obeliskenförmigen und pylonenartigen Türmchen, die nicht nur die Eingangsfassade der Kirche flankieren, sondern auch an den Ecken des Querhauses der Kirche stehen. Die ingravierten weißen Steine an der Fassade in der Zahl von Zehn erinnern an das Gebot des Karmelterinnenordens: Bete täglich den Rosenkranz und sind zugleich ein Vanitativmotiv. 2. Die Klosterkirche der unbeschuhten

  13. Rethinking the diagnosis of von Willebrand disease.

    Science.gov (United States)

    Favaloro, Emmanuel J

    2011-01-01

    von Willebrand disease (VWD) is the most common inherited bleeding disorder and arises from deficiencies and/or defects in the plasma protein von Willebrand factor (VWF). VWD is classified into 6 different types, with type 1 identified as a (partial) quantitative deficiency of VWF, type 3 defined by a (virtual) total deficiency of VWF, and type 2 identifying four separate types (2A, 2B, 2M, 2N) characterised by qualitative defects. The classification is based on phenotypic assays including FVIII, VWF:Ag and VWF activity, typically by ristocetin cofactor (VWF:RCo), but also increasingly by collagen binding (VWF:CB). Phenotypic testing may be supplemented by multimer analysis, RIPA, and VWF:FVIII binding. Although genetic analysis is not required to diagnose VWD or to define a classification type, it may be useful in discrete situations. The current review briefly covers this diagnostic process, with a focus on newer approaches, including extended test panels and the use of data from desmopressin challenges as a diagnostic tool. Copyright © 2011 Elsevier Ltd. All rights reserved.

  14. [Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2007-01-01

    Arvustus: Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918. In : Ostseeprovinzen, baltische Staaten und das Nationale. Münster : LIT, 2005, lk. 403-414. 1918. aastast pärit lendlehest, mille käekirja järgi otsustades on kirjutanud Viktor Kingissepp

  15. [Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918] / Paul Kaegbein

    Index Scriptorium Estoniae

    Kaegbein, Paul

    2007-01-01

    Arvustus: Heinz von zur Mühlen. Das Bürgertum Fordert Blut. Ein Bolschewistiches Flugblatt von 1918. In : Ostseeprovinzen, baltische Staaten und das Nationale. Münster : LIT, 2005, lk. 403-414. 1918. aastast pärit lendlehest, mille käekirja järgi otsustades on kirjutanud Viktor Kingissepp

  16. Alexander von Humboldt in Daniel Kehlmanns Welt

    Directory of Open Access Journals (Sweden)

    Ottmar Ette

    2012-12-01

    Full Text Available Zusammenfassung Wie stark sich im Verlauf des zurückliegenden Vierteljahrhunderts der Bekanntheitsgrad Alexander von Humboldts in der deutschsprachigen Öffentlichkeit verändert hat, zeigen nicht nur Fernsehumfragen zu den berühmtesten Deutschen, in denen Alexander von Humboldt mittlerweile figuriert, oder Fernsehserien, die über aktuelle Expeditionen berichten und auf Humboldts Namen zurückgreifen. Am deutlichsten vielleicht belegt dies der enorme Erfolg von Daniel Kehlmanns Roman Die Vermessung der Welt, der ohne die zuvor skizzierte Entwicklung nicht denkbar gewesen wäre. Es ist vor diesem Hintergrund nicht nur reizvoll, sondern aufschlußreich, sich mit dem großen Erfolg dieses kleinen Romans zu beschäftigen. Worum geht es in Die Vermessung der Welt? Und wie läßt sich das „Phänomen Kehlmann“ aus etwas größerer Distanz erklären? Abstract In the last 25 years, Alexander von Humboldt‘s popularity has radically changed in the german-speaking public opinion. Proof of this are not only television surveys about the most famous germans - in which Alexander von Humboldt now regularly figures - or television series about contemporary expeditions, which constantly refer to Humboldt‘s name; perhaps what most clearly verifies this change is the great success of Daniel Kehlmann‘s novel Die Vermessung der Welt. Without the recent developments outlined above, this novel‘s degree of impact would have been unimaginable. To study the great success of this text against this backdrop is not only attractive, but also revealing. What is Die Vermessung der Welt really about? And how can we explain the „Kehlmann phenomenon“ from a greater distance? Resumen La popularidad de Alejandro de Humboldt ha cambiado profundamente dentro del último cuarto de siglo en la opinión pública de habla alemana. Prueba de esto son no sólo las encuestas televisivas sobre los alemanes más famosos, dentro de las cuales figura en estos momentos Alejandro

  17. Ludwig Leichhardt und Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Aliya-Katarina Südfels

    2012-10-01

    Full Text Available Zusammenfassung Im Juli des Jahres 1841 kommt es zu einem Treffen zwischen zwei Männern, das zunächst belanglos erscheint, sich aber Jahre später als wichtige historische Begebenheit herausstellen wird. In seinem Pariser Büro empfängt der 71jährige Naturforscher Alexander von Humboldt den jungen Preußen Ludwig Leichhardt. Der angehende Naturwissenschaftler erhofft sich Zuspruch und Empfehlung des berühmten Alexander von Humboldts. Die Unterredung ist kurz und verläuft für Leichhardt ergebnislos. Es wird das einzige Treffen der beiden Naturwissenschaftler bleiben. Aus heutiger Sicht unverständlich, da Ludwig Leichhardt und Alexander von Humboldt mehr verband, als ihre Leidenschaft für die Naturwissenschaften. Viel zu wenig ist sich bis jetzt den biographischen Analogien und den vergleichbaren geographischen Leistungen der beiden Preußen gewidmet worden. Abstract During July 1841 a meeting between two men takes place, which seems to have been extraneous, but turns out to be a significant historical incident. 71 year old natural scientist Alexander von Humboldt welcomes young Ludwig Leichhardt from Prussia in his office in Paris. The prospective young scientist expects help and references from famous Alexander von Humboldt. The conversation is short and ends from Leichhardt’s point of view without results. Unfortunately this is going to be the only meeting between the two scientists even though the two Prussians have more in common than their passion for the natural sciences. Way too seldomly have biographical analogy and geographical productivity of the two men been compared. Résumé En juillet 1841 une rencontre entre deux hommes a lieu, qui au premier abord semble sans importance, mais qui des années plus tard est considéré comme un événement historique majeur. Dans son bureau parisien, le naturaliste Alexandre de Humboldt, alors âgé de 71 ans, reçoit le jeune Prussien Ludwig Leichhardt. Le jeune scientifique en devenir

  18. Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease.

    Science.gov (United States)

    Cohen-Tannoudji, M; Marchand, P; Akli, S; Sheardown, S A; Puech, J P; Kress, C; Gressens, P; Nassogne, M C; Beccari, T; Muggleton-Harris, A L

    1995-12-01

    Tay-Sachs disease is an autosomal recessive lysosomal storage disease caused by beta-hexosaminidase A deficiency and leads to death in early childhood. The disease results from mutations in the HEXA gene, which codes for the alpha chain of beta-hexosaminidase. The castastrophic neurodegenerative progression of the disease is thought to be a consequence of massive neuronal accumulation of GM2 ganglioside and related glycolipids in the brain and nervous system of the patients. Fuller understanding of the pathogenesis and the development of therapeutic procedures have both suffered from the lack of an animal model. We have used gene targeting in embryonic stem (ES) cells to disrupt the mouse Hexa gene. Mice homozygous for the disrupted allele mimic several biochemical and histological features of human Tay-Sachs disease. Hexa-/- mice displayed a total deficiency of beta-hexosaminidase A activity, and membranous cytoplasmic inclusions typical of GM2 gangliosidoses were found in the cytoplasm of their neurons. However, while the number of storage neurons increased with age, it remained low compared with that found in human, and no apparent motor or behavioral disorders could be observed. This suggests that the presence of beta-hexosaminidase A is not an absolute requirement of ganglioside degradation in mice. These mice should help us to understand several aspects of the disease as well as the physiological functions of hexosaminidase in mice. They should also provide a valuable animal model in which to test new forms of therapy, and in particular gene delivery into the central nervous system.

  19. GM2 gangliosidoses in Spain: analysis of the HEXA and HEXB genes in 34 Tay-Sachs and 14 Sandhoff patients.

    Science.gov (United States)

    Gort, Laura; de Olano, Natalia; Macías-Vidal, Judit; Coll, M A Josep

    2012-09-10

    The GM2 gangliosidoses are autosomal recessive lysosomal storage diseases caused by a deficiency of the β-hexosaminidase A enzyme. This enzyme is composed of two polypeptide chains designated the α- and β- subunits and it interacts with the GM2 activator protein. The HEXA and HEXB genes encode the α-subunit and the β-subunit, respectively. Mutations in these genes are causative of Tay-Sachs disease (HEXA) and Sandhoff disease (HEXB). We analyzed the complete HEXA gene in 34 Spanish patients with Tay-Sachs disease and the HEXB gene in 14 Spanish patients with Sandhoff disease. We identified 27 different mutations, 14 of which were novel, in the HEXA gene and 14 different mutations, 8 of which unreported until now, in the HEXB gene, and we attempted to correlate these mutations with the clinical presentation of the patients. We found a high frequency of c.459+5G>A (IVS4+5G>A) mutation in HEXA affected patients, 22 of 68 alleles, which represent the 32.4%. This is the highest percentage found of this mutation in a population. All patients homozygous for mutation c.459+5G>A presented with the infantile form of the disease and, as previously reported, patients carrying mutation p.R178H in at least one of the alleles presented with a milder form. In HEXB affected patients, the novel deletion c.171delG accounts for 21.4% of the mutant alleles (6/28). All patients with this deletion showed the infantile form of the disease. The Spanish GM2 gangliosidoses affected patients show a great mutational heterogeneity as seen in other inherited lisosomal diseases in this country. Copyright © 2012. Published by Elsevier B.V.

  20. Outcomes of arthroscopic Hill-Sachs remplissage and anterior Bankart repair: a retrospective controlled study including ultrasound evaluation of posterior capsulotenodesis and infraspinatus strength assessment.

    Science.gov (United States)

    Merolla, Giovanni; Paladini, Paolo; Di Napoli, Giuseppe; Campi, Fabrizio; Porcellini, Giuseppe

    2015-02-01

    Hill-Sachs lesions are compression fractures that result from shoulder dislocation. They involve "engaging" the humeral head on the anterior glenoid rim when the arm is abducted and externally rotated. The defect grows as the number of dislocations increases. Arthroscopic remplissage and anterior Bankart repair do not significantly affect infraspinatus strength while ensuring healing of the capsulotenodesis. Cohort study; Level of evidence, 3. Sixty-one patients with traumatic anterior shoulder instability treated by arthroscopic Bankart repair and Hill-Sachs remplissage at least 24 months previously were compared with a control group of 40 healthy participants. Preoperative imaging included magnetic resonance imaging for Bankart lesion identification and computed tomography to quantify the humeral head defect. Active range of motion and clinical scores (Walch-Duplay, Constant-Murley, and Rowe) were assessed. External rotation (ER) and internal rotation (IR) were measured with arm at the side (ER1 and IR1) and abducted at 90° (ER2 and IR2). Infraspinatus strength was assessed with the scapula free (infraspinatus strength test [IST]) and retracted (infraspinatus scapula retraction test [ISRT]). Infraspinatus tenodesis and posterior capsulodesis healing were evaluated by ultrasound (US). The follow-up median was 39.5 months (range, 24-56 months). One patient experienced a recurrence of instability at 34 months. In the remplissage patients, ER1 was significantly lower in the affected compared with the unaffected shoulder (P lesions. The ER and IR restriction does not significantly affect quality of life. Infraspinatus strength recovery is satisfactory even compared with healthy subjects. Ultrasound examination allows accurate evaluation of capsulotenodesis healing. © 2014 The Author(s).

  1. Neurochirurgische Therapie von atypischen neuropathischen Gesichtsschmerzen und Clusterkopfschmerz mit Darstellung von Kernaspekten neurochirurgischer Schmerztherapie

    Directory of Open Access Journals (Sweden)

    Eisner W

    2016-01-01

    Full Text Available Die primäre Behandlung von Schmerzen jeglicher Art erfolgt pharmakologisch, physikalisch-medizinisch oder verhaltenstherapeutisch. Wenn diese konservativen Therapiemaßnahmen versagen, geraten Therapeuten und Patienten schnell in große Not; Alternativmethoden werden herangezogen. Solange geholfen wird und eine Schmerzerleichterung erkennbar ist, ist nichts dagegen einzuwenden. Versagen auch diese Methoden, sucht der Patient erneut Spezialisten auf, denen die schwere Aufgabe zukommt, dem Patienten weitere therapeutische Möglichkeiten zu ermöglichen oder ihn seinem Schicksal zu überlassen.br Die vorliegende Arbeit über atypische Gesichtsschmerzen möchte über neurochirurgische Behandlungsmöglichkeiten informieren. Die Komplexität dieser Erkrankungen benötigt die Interdisziplinarität von Neurologen, Schmerztherapeuten sowie Psychologen und nicht Beisätze wie „Vorsicht, Chirurgen, die schneiden überall rein und dann erst …“.

  2. Charakterisierung von Mutanten im Lösungsmittelstoffwechsel von Clostridium acetobutylicum

    OpenAIRE

    Hönicke, Daniel

    2015-01-01

    Im Rahmen dieser Arbeit wurden insgesamt neun durch ClosTron-basierte Mutagenese erhaltene Insertionsmutanten von C. acetobutylicum ATCC 824 einer umfangreichen Charakterisierung unterzogen. Für alle im Batch-Fermentationsmaßstab und/oder in kontinuierlicher Kultur fermentierten Stämme erfolgte eine globale Analyse des Transkriptoms unter Verwendung der DNA-Microarray-Technologie. Für eine Analyse des Acetat- und Aceton-Stoffwechsels wurden Stämme mit einer inaktivierten Phosphotransacetyl...

  3. Update: SPECT in der Diagnostik von Parkinson-Syndromen

    Directory of Open Access Journals (Sweden)

    Pirker W

    2015-01-01

    Full Text Available Die Diagnose des Morbus Parkinson fußt primär auf Anamnese und klinischer Untersuchung. Die Abgrenzung von milden Bewegungsstörungen bei ansonsten gesunden älteren Personen, von medikamenteninduzierten und vaskulären Parkinson-Syndromen sowie von Tremor-Syndromen kann jedoch schwierig sein. Die Differenzierung zwischen M. Parkinson und atypischen Parkinson-Erkrankungen wie der Multisystematrophie (MSA und der progressiven supranukleären Paralyse (PSP ist im Frühstadium häufig unmöglich und kann auch in fortgeschrittenen Stadien Probleme bereiten. Die SPECT-Untersuchung mit Dopamin-Transporter- (DAT- Liganden wie 123I-FP-CIT erlaubt mit wenigen Ausnahmen bereits im Frühstadium eine Dokumentation der dopaminergen Degeneration beim M. Parkinson und atypischen Parkinson- Erkrankungen und damit meist eine Abgrenzung von nichtdegenerativen Parkinson- und Tremor-Syndromen. Sie kann die einzelnen degenerativen Parkinson-Syndrome jedoch nicht voneinander unterscheiden. Die Untersuchung postsynaptischer Dopamin- D2-Rezeptoren mit der 123I-IBZM-SPECT kann zur Differenzierung von M. Parkinson und MSA bzw. PSP beitragen. Neueren Untersuchungen zufolge dürften die Untersuchung des zerebralen Glukosemetabolismus mittels 18F-FDG-PET sowie moderne MRT-basierte Methoden in dieser Fragestellung jedoch eine höhere Sensitivität und Spezifität haben. Während Medikamente die diagnostische Aussagekraft von DAT-SPECT-Untersuchungen selten beeinflussen, kann das Ergebnis der IBZM-SPECT sowohl durch dopaminerge Substanzen als auch durch Dopaminantagonisten stark verfälscht werden. Die richtige Interpretation von SPECT-Daten setzt darüber hinaus die Kenntnis der individuellen strukturellen bildgebenden Befunde voraus. Eine MRT- oder CCTUntersuchung sollte zum Ausschluss von läsionellen Parkinson-Syndromen und zur Dokumentation von Kopathologien immer Bestandteil der Parkinson-Abklärung sein.

  4. Informationssuchverhalten als Grundlage für die Gestaltung von Veranstaltungen zum Erwerb von Informationskompetenz

    Directory of Open Access Journals (Sweden)

    Martin Wollschläger-Tigges

    2015-09-01

    Full Text Available Für die Gestaltung bibliothekarischer Veranstaltungen zum Erwerb von Informationskompetenz stellen die bisherigen Ergebnisse und Befunde der Forschung zum Informationssuchverhalten eine wertvolle Grundlage dar, indem bestimmte und v.a. typische Verhaltensmuster, Routinen und Präferenzen im Umgang mit Informationsressourcen und Informationen in konzeptionelle und inhaltliche Anpassungen von IK- Veranstaltungen eingebracht und eingesetzt werden. Das Informationssuchverhalten untersucht sowohl individuelle als auch kollektive Informationsprozesse und Faktoren, die diese maßgeblich beeinflussen. Hierzu werden der gesamte Informationsprozess oder einzelne Abschnitte untersucht, die den Information Need, Seeking und Using (INSU-Prozess bilden. Die Befunde der einzelnen INSU-Prozesses-Einheiten zeigen, dass Faktoren wie Informationsbedarf, Informationsart und -form sowie die Einbindung in übergeordnete Arbeitsprozesse wesentlichen Einfluss auf das Informationssuchverhalten haben. Des Weiteren konnte die ISB-Forschung eine Klassifizierung von Benutzergruppen entwickeln und z.B. Fast Surfers, Broad Scanners und Deep Divers charakterisieren bzw. auch das Bouncing oder Flicking Behavior beschreiben. Hinzu kommen mehrere Modelle, die Informationssuchverhalten und Informationsverhalten in bestimmten Situationen nachbilden und darstellen können.

  5. Valence bond and von Neumann entanglement entropy in Heisenberg ladders.

    Science.gov (United States)

    Kallin, Ann B; González, Iván; Hastings, Matthew B; Melko, Roger G

    2009-09-11

    We present a direct comparison of the recently proposed valence bond entanglement entropy and the von Neumann entanglement entropy on spin-1/2 Heisenberg systems using quantum Monte Carlo and density-matrix renormalization group simulations. For one-dimensional chains we show that the valence bond entropy can be either less or greater than the von Neumann entropy; hence, it cannot provide a bound on the latter. On ladder geometries, simulations with up to seven legs are sufficient to indicate that the von Neumann entropy in two dimensions obeys an area law, even though the valence bond entanglement entropy has a multiplicative logarithmic correction.

  6. A von Bertalanffy growth model with a seasonally varying coefficient

    Science.gov (United States)

    Cloern, James E.; Nichols, Frederic H.

    1978-01-01

    The von Bertalanffy model of body growth is inappropriate for organisms whose growth is restricted to a seasonal period because it assumes that growth rate is invariant with time. Incorporation of a time-varying coefficient significantly improves the capability of the von Bertalanffy equation to describe changing body size of both the bivalve mollusc Macoma balthicain San Francisco Bay and the flathead sole, Hippoglossoides elassodon, in Washington state. This simple modification of the von Bertalanffy model should offer improved predictions of body growth for a variety of other aquatic animals.

  7. Bioaktivitäten von Wertstoffen aus Saccharomyces Hefen

    OpenAIRE

    Jährig, Silke Christiane

    2007-01-01

    In der vorliegenden Arbeit wurden die antioxidative Aktivität sowie die immunmodulierende Kapazität von Zellwänden und Zellwandbestandteilen der Bierhefe Saccharomyces cerevisiae untersucht. Die Zellwände von Saccharomyces-Hefen bestehen aus (1→3),(1→6)-β-D-Glucan, Mannanen, Proteinen und Lipiden. Als potentieller Immunmodulator ist vor allem das (1→3),(1→6)-β-D-Glucan von Interesse. Vor kurzem konnte für dieses Glucan zusätzlich eine antioxidative Wirkung nachgewiesen werden [KOGAN et al., 2...

  8. Emotionales Erleben von Lehrkräften beim Unterrichten

    OpenAIRE

    Frenzel, Anne C.; Götz, Thomas

    2007-01-01

    Ziel dieser Studie war es, das Ausmaß an Variabilität des Erlebens von Freude, Angst und Ärger bei Lehrkräften zu ermitteln, das auf ihre Persönlichkeit, das Unterrichtsfach (hier: Mathematik vs. Physik) und die jeweils unterrichtete Klasse zurückzuführen ist. Zudem wurde der Einfluss von Person- und Kontextmerkmalen auf das emotionale Erleben beim Unterrichten untersucht. 59 Gymnasiallehrkräfte (9 weiblich) gaben anhand von einem Fragebogen sowie einem Tagebuch Auskunft über ihre Unterrichts...

  9. Über die Ethoxylierung von Octanol im Mikrostrukturreaktor

    OpenAIRE

    2015-01-01

    Die basisch katalysierte ringöffnende Polymerisation von Ethylenoxid mit Octanol (Ethoxylierung) wurde in einem kontinuierlich betriebenen Mikrostrukturreaktor untersucht. Es wurde die Kinetik dieser Reaktion unter intensivierten Bedingungen ermittelt. Die Reaktion wurde homogen in der Flüssigphase durchgeführt, bei Drücken bis 100 bar und Temperaturen im Bereich von 130 °C bis 240 °C. Für die Propagationsreaktion eine Aktivierungsenergie von 73 kJ/mol gefunden. Es wurde gezeigt, dass die Pro...

  10. Modernisation of ventilation systems; Modernisierung von Lueftungsanlagen

    Energy Technology Data Exchange (ETDEWEB)

    Richter, W. [Technische Univ. Dresden (Germany). Inst. fuer Thermodynamik und Technische Gebaeudeausruestung

    1997-12-31

    When redeveloping buildings it is common to use window constructions with air-tight rabbets which obviate the inflow of fresh air almost entirely. This leads to the well-known structural-physics and hygienic consequences. As an added effect, the distinctly enhanced thermal insulation results in changes in dynamic heat loss. The paper focuses on the issues of how to safeguard the inflow of fresh air, and the heating capacity of radiators. (MSK) [Deutsch] Da die bei Gebaeudesanierungen eingesetzten fugendichten Fensterkonstruktionen die Nachstroemmoeglichkeiten fuer die Zuluft fast ganz unterbinden, fuehrt das zu den bekannten bauphysikalischen und hygienischen Konsequenzen. Dazu kommen veraenderte dynamische Waermverlustverhaeltnisse aufgrund der deutlich verbesserten Waermedaemmung. Im Folgenden wird schwerpunktmaessig auf die Probleme Zuluftsicherung und Waermeleistung von Heizkoerpern eingegangen.

  11. Wirksame Alternativen zur Behandlung von klimakterischen Beschwerden

    Directory of Open Access Journals (Sweden)

    Stute P

    2011-01-01

    Full Text Available Vasomotorische Beschwerden (VMS werden von 75 % der postmenopausalen Frauen angegeben. Neben der konventionellen Hormontherapie stehen verschiedene Behandlungsmöglichkeiten aus dem Bereich der Alternativ- und Komplementärmedizin (CAM zur Verfügung. Soja Isoflavone und Traubensilberkerze können bei jüngeren peri- und frühen postmenopausalen Frauen mit leichten bis moderaten VMS hilfreich sein. Die Studienlage zur CMA ist jedoch insgesamt unzureichend. In Zukunft wäre es wünschenswert, nicht nur das Wirkungsvermögen, sondern auch die Effizienz einer Behandlung in randomisiert-kontrollierten Studien zu untersuchen. Hierfür bietet sich die ICF Klassifikation der WHO an.

  12. Hermann von Helmholtz and the empiricist vision.

    Science.gov (United States)

    Turner, R S

    1977-01-01

    The philosophical convictions of Hermann von Helmholtz and the empiricist psychology he developed have been extensively discussed in historical literature. This literature has not usually emphasized the tacti assumptions about human physiology that underlaid these convictions nor the way in which Helmholtz's epistemology served as a methodological directive in his research. Helmholtz assumed nerve transmission between sense organs and the mind to be a passive process. Distortion in stimulus patterns occurs physically in the sense organs, which can therefore be treated through mechanical analogies. Stimuli become converted to the perceptions of consciousness through mental processes that are essentially analogous to conscious, inductive inference and that are therefore susceptible, in principle, to introspective investigation. This view of mental function reflected Helmholtz's intellectual debt to German idealism, especially to the philosophical views of J.G. Fichte.

  13. Hepatische Effekte von Wachstumshormon auf den Glukosestoffwechsel

    Directory of Open Access Journals (Sweden)

    Rufinatscha K

    2015-01-01

    Full Text Available Untherapierter Wachstumshormonmangel im Erwachsenenalter (AGHD ist mit viszeraler Adipositas, Dyslipidämie, Insulinresistenz und Fettleber verbunden. Interessanterweise finden sich viele der AGHD-Merkmale auch bei Patienten mit metabolischem Syndrom. Die nichtalkoholische Fettlebererkrankung (NAFLD gilt als hepatische Manifestation des metabolischen Syndroms. In einigen Studien wurden bei Patienten mit NAFLD verminderte Konzentrationen von zirkulierendem IGF-1, dessen Synthese zu einem großen Teil durch Wachstumshormon (GH reguliert wird, beschrieben. Mäuse, welche eine hepatische Wachstumshormondefizienz aufweisen, zeigen zahlreiche phänotypische Charakteristika des metabolischen Syndroms, unter anderen auch eine Fettlebererkrankung. Dies legt einen Zusammenhang zwischen dem Wachstumshormon und der Entstehung einer NAFLD nahe. Ziel unserer Studie ist es, in einem Zellkulturmodell die Effekte des Wachstumshormons auf den intrazellulären Glukosestoffwechsel näher zu untersuchen. Im Detail sollen Auswirkungen einer verminderten Wachstumshormonrezeptorexpression auf den Insulinsignaltransduktionsweg, den Glykogengehalt und auf Schlüsselenzyme der Glukoneogenese untersucht werden. Präliminäre Daten zeigen, dass eine verminderte Wachstumshormonrezeptorexpression mit intrazellulären Veränderungen des hepatischen Glukosestoffwechsels verbunden ist. Die verminderte Insulinsensitivität könnte auf Alterationen im Insulinsignaltransduktionsweg und Änderungen der Glukoneogenese zurückzuführen sein. Diese präliminären Daten weisen darauf hin, dass Wachstumshormon einen direkten Einfluss auf den Glukosestoffwechsel in der Leber hat. Zudem legen sie nahe, dass Veränderungen im Wachstumshormonstoffwechsel einen wichtigen pathophysiologischen Mechanismus in der Entstehung der Fettlebererkrankung bei Patienten mit metabolischem Syndrom darstellen könnten. Der folgende Artikel soll einen kurzen Überblick über die Effekte von Wachstumshormon

  14. Batlles reales y batlles de sachs : contribución al estudio de las jurisdicciones locales catalanas en la Baja Edad Media y a las puertas de la Edad Moderna

    Directory of Open Access Journals (Sweden)

    María Asunción Zapata Buxens

    2000-01-01

    Full Text Available Batlles reales y batlles de sachs. Contribución al estudio de las jurisdicciones locales catalanas en la Baja Edad Media y a las puertas de la Edad Moderna. A través del ejemplo de la baronía Desbosc, el estudio se ocupa de la resistencia de los habitantes de las poblaciones catalanas contra la jurisdicción encarnada tanto por el batlle de sachs, el juez señorial, como por el batlle real, el juez del monarca, porque ambos magistrados representan a los ojos de los municipios la misma clase de justicia. Ésta es la prueba de la pervivencia de elementos feudales, fiscales y legales, heredados de la Edad Media en la sociedad catalana de los primeros tiempos modernos. Batlles reales and batlles de sachs.A contribution to the study of Catalán local jurisdictions at the end of the Middle Ages and at the dawn of the Modern Times. Using the baronía Desbosc as an example, the study deals with the resistance of the inhabitants of the Catalán villages both against the jurisdiction embodied by the batlle de sachs, the lord's official, and that embodied by the batlle real, the royal official, because both magistrales are considered by the municipalities as representing the same kind of justice. This is the evidence of the survival of legal and fiscal feudal elements inherited from the Middle Ages in Catalán society in the Early modern times.

  15. Von Krahli Teater viis Helsingisse kaks menulavastust / Andres Laasik

    Index Scriptorium Estoniae

    Laasik, Andres, 1960-2016

    2003-01-01

    Von Krahli Teater esineb 29. nov. Helsingis "Baltic Circle" festivalil lavastustega "Luikede järv" ja "Taksojuhid". Tutvustatakse lühidalt ka paari olulisemat soome lavastust ("Puksiirabi" ja "Hamlet"), mis tulevad festivalil esitamisele

  16. CFD-Simulation von Mehrkomponentenadsorption in einem Festbett

    OpenAIRE

    2016-01-01

    von Clemens Gößnitzer Arbeit an der Bibliothek noch nicht eingelangt - Daten nicht geprueft Abweichender Titel nach Übersetzung der Verfasserin/des Verfassers Technische Universität Wien, Univ., Diplomarbeit, 2016

  17. Spurensuche einer Rezeptionsgeschichte Alexander von Humboldt und Johann Gottfried Herder

    National Research Council Canada - National Science Library

    Bernhard Hunger

    2009-01-01

    Article in German, Abstracts in English, German and Spanish.Alexander von Humboldt's work displays traces of Johann Gottfried Herder which are as multifaceted as the references to the latter are scarce...

  18. Von Krahli Teatri lavastus pääses tippfestivalile

    Index Scriptorium Estoniae

    1999-01-01

    Von Krahli Teatri uuendatud lavastus "Eesti mängud. Pulm" esietendub festivalil Theater Der Welt Berliinis. Peeter Jalaka multimeediaetendus Eesti ajaloost ja traditsioonidest osaleb ka suveteatrite festivalil Hamburgis, seejärel antakse kuus etendust Amsterdamis

  19. Magnus Georg von Paucker (1787-1855) / Eckhard Spring

    Index Scriptorium Estoniae

    Spring, Eckhard

    2013-01-01

    Eestis sündinud ja Tartu Ülikoolis õppinud silmapaistvast baltisaksa teadlasest ja tema lapselapsest Alexandrine Pauckerist. 23. novembril 2012 Jelgavas/Mitaus toimunud Magnus Georg von Pauckerile pühendatud teaduskonverentsist

  20. Von Krahli Teatri lavastus pääses tippfestivalile

    Index Scriptorium Estoniae

    1999-01-01

    Von Krahli Teatri uuendatud lavastus "Eesti mängud. Pulm" esietendub festivalil Theater Der Welt Berliinis. Peeter Jalaka multimeediaetendus Eesti ajaloost ja traditsioonidest osaleb ka suveteatrite festivalil Hamburgis, seejärel antakse kuus etendust Amsterdamis

  1. Nash y von Neumann: mundos posibles y juegos de lenguaje

    Directory of Open Access Journals (Sweden)

    Salazar , Boris

    2004-06-01

    Full Text Available Este ensayo emplea las nociones de juego de lenguaje y de equivalencia entre juegos para examinar la decisión de John Nash de no jugar el juego coalicional que propuso John von Neumann. El argumento central es que Nash concibió una clase de mundos posibles incompatible con la de von Neumann, y que en el origen de esa divergencia estarían sus distintas nociones de racionalidad.

  2. Kooperation mit der Industrie bei der Ausbildung von Softwareingenieuren

    OpenAIRE

    2010-01-01

    Vor allem in Regionen, in denen der Personalbedarf der Unternehmen nicht durch Absolventen gedeckt werden kann, sollte sich die Hochschulausbildung auch an den Anforderungen der Industrie orientieren. In diesem Beitrag werden diese Anforderungen für Softwareingenieure für den Standort Görlitz spezifiziert und es werden Kooperationsmöglichkeiten von Hochschule und lokalen Unternehmen aufgezeigt. Dabei wird auf die praxisorientierte Ausbildung, auf die Übernahme von Ausbildungsverantwortung dur...

  3. Hans von Hattingberg (1879-1944) Leben und Werk

    OpenAIRE

    Keifenheim, Katharina Eva

    2011-01-01

    Hans von Hattingberg, geboren am 18.11.1879 in Wien, wird heute vor allem mit dem Deutschen Institut für Psychologische Forschung und Psychotherapie („Göring-Institut“) in Verbindung gebracht, wo er sich mit der „Neuen Deutschen Seelenheilkunde“ und der Erarbeitung von „Thesen zur Neurosenlehre“ befasste. Interessanterweise war Hattingberg bis 1932 eher eine Randfigur in der Psychotherapeutenszene und galt vielen als unbelehrbarer Querulant. Viele seiner Arbeiten wurden nie veröffentlicht, u...

  4. Numerical Analysis Of Buckling Of Von Mises Planar Truss

    Directory of Open Access Journals (Sweden)

    Kalina Martin

    2015-12-01

    Full Text Available A computational algorithm of a discrete model of von Mises planar steel truss is presented. The structure deformation is evaluated by seeking the minimal potential energy. The critical force invented by mathematical solution was compared with solution by computer algorithm. Symmetric and asymmetric effects of initial shape of geometric imperfection of axis of struts are used in model. The shapes of buckling of von Mises planar truss of selected vertical displacement of top joint are shown.

  5. Wie vergleichbar sind Ergebnisse von Rechtschreib-und Lesetests?

    OpenAIRE

    Steinhauser, Susanne

    2006-01-01

    Eine umschriebene Lese-Rechtschreibstörung (ICD-10: F81) ist durch eine Diskrepanz zwischen den allgemeinen kognitiven Fähigkeiten eines Kindes und dessen Lese-Rechtschreibleistungen gekennzeichnet. Für die Diagnostik steht eine Vielzahl von Lese- und Rechtschreibtests zur Verfügung. In der Studie wurde untersucht, ob die Diagnosestellung von der Wahl des Testverfahrens abhängt. Es wurden Kinder mit mehreren Rechtschreib- und Lesetests untersucht. Die allgemeinen kognitiven Fähigkeiten wur...

  6. Modellbasierte Merkmalsplanung zur objektbezogenen laserscannerbasierten Navigation von Fahrzeugen

    OpenAIRE

    Stahn, Roland

    2010-01-01

    In dieser Dissertation wird ein neues System zur modellbasierten Merkmalsplanung für die objektbezogene laserscannerbasierte Navigation von Fahrzeugen vorgestellt. Die robuste Orientierung und Bewegung in natürlichen Umgebungen ist eine zentrale Problemstellung der mobilen Robotik. Die präzise Navigation relativ zu Objekten der Umgebung bildet ein Teilgebiet, welches speziell für die Realisierung von zukünftigen Assistenz- und Autonomiefunktionen bei Fahrzeugen, fahrerlosen Transportsystemen ...

  7. Untersuchungen zum enzymatisch-physikalischen Aufschluss von Apfeltrester

    OpenAIRE

    Schalow,Sebastian

    2009-01-01

    Apfeltrester fallen in großen Mengen als Reststoffe bei der industriellen Fruchtsaftproduktion an. Neben der Pektinherstellung können Apfeltrester u. a. für die Alkoholerzeugung genutzt werden. Im Gegensatz zur Produktion von technischem Alkohol werden bei der Trinkalkoholherstellung jedoch höhere Anforderungen an die chemische Zusammensetzung und die sensorischen Eigenschaften der erzeugten Destillate gestellt. Apfeltrester besitzen eine Trockensubstanz von ca. 25 %, die sich zum größten Tei...

  8. Geschlechterstereotype - Qualifikationsbarrieren von Frauen in der Fußballtrainerausbildung?

    OpenAIRE

    Weigelt-Schlesinger, Yvonne

    2007-01-01

    Eines der letzten fast vollständig männlichen dominierten Reservoirs des Sports ist der Trainerbereich. Vor dem Hintergrund dieser Einsicht setzt sich die Arbeit mit der Frage auseinander, weshalb Frauen erst gar keine Ausbildung zur Trainerin beginnen oder die begonnene Ausbildung wieder abbrechen. Dabei interessiert insbesondere die Bedeutung von Geschlechtsstereotypen bei der Ausgrenzung von Frauen aus oder der Benachteiligung während der Trainerausbildung. So fragt die Autorin danach,...

  9. Identifizierung und Charakterisierung eines Sdr-Proteins von Staphylococcus saprophyticus

    OpenAIRE

    Sakinç, Türkân

    2001-01-01

    Gegenstand der vorliegenden Arbeit war es, das Oberflächenprotein Ssp zu klonieren und zu charakterisieren. Stattdessen wurde ein neues Zellwand-assoziertes Protein, das SdrI, ein MSCRAMM, kloniert. Dies sollte zur Klärung der Uropathogenität von Staphylococcus saprophyticus weiterhelfen. Die Voraussetzungen zur Untersuchung der Funktion des SdrI Protein von Staphylococcus saprophyticus wurde durch die Konstruktion einer isogenen Mutante geschaffen. Die Bedeutung der SdrI-Protein ...

  10. Politische Bildung im Kontext von Regierung, Unterricht und Zucht

    Directory of Open Access Journals (Sweden)

    Thomas Rucker

    2014-02-01

    Full Text Available Johann Friedrich Herbart (1776-1841 gilt als der Begründer der wissenschaftlichen Pädagogik. In diesem Beitrag wird zu zeigen versucht, dass Herbart die Unterstützung politischer Bildung als eine Aufgabe von Regierung, Unterricht und Zucht bestimmt und in seinem Werk wichtige „Bausteine“ für eine Theorie der politischen Bildung unter den Bedingungen von Erziehung vorlegt hat. Nach Herbart ist das politische Selbst- und Weltverhältnis auf Sachverhalte bezogen, die nicht nur die Lebensführung einzelner Menschen, sondern die Lebensführung einer Mehrzahl von Menschen betreffen. Nicht das Zusammenleben von Menschen generell ist jedoch Orientierungsgesichtspunkt des politischen Selbst- und Weltverhältnisses, sondern nur das problematisch gewordene Zusammenleben. Politik ergibt sich nach Herbart aus einem Konflikt hinsichtlich der Frage, wie das Zusammenleben von Menschen geregelt sein sollte. Während die Regierung lediglich mittelbar einen Beitrag zur politischen Bildung leistet, indem sie die Voraussetzungen für Unterricht und Zucht bereitstellt, fungieren die beiden zuletzt genannten Formen von Erziehung als die eigentlichen Medien, in denen die politische Bildung im Sinne Herbarts ihren Ort hat.

  11. Prophylaxis escalation in severe von Willebrand disease: A prospective study from the von Willebrand Disease Prophylaxis Network

    NARCIS (Netherlands)

    T.C. Abshire (Thomas Calvin); J. Cox-Gill; C.L. Kempton; F.W.G. Leebeek (Frank); M. Carcao (M.); P. Kouides (P.); S. Donfield (S.); E. Berntorp

    2015-01-01

    textabstractBackground: Treatment of mucosal bleeding (epistaxis, gastrointestinal bleeding, and menorrhagia) and joint bleeding remains problematic in clinically severe von Willebrand disease (VWD). Patients are often unresponsive to treatment (e.g. desmopressin or antifibrinolytic therapy) and may

  12. Electronic Resource Management System. Vernetzung von Lizenzinformationen

    Directory of Open Access Journals (Sweden)

    Michaela Selbach

    2014-12-01

    Full Text Available In den letzten zehn Jahren spielen elektronische Ressourcen im Bereich der Erwerbung eine zunehmend wichtige Rolle: Eindeutig lässt sich hier ein Wandel in den Bibliotheken (fort vom reinen Printbestand zu immer größeren E-Only-Beständen feststellen. Die stetig wachsende Menge an E-Ressourcen und deren Heterogenität stellt Bibliotheken vor die Herausforderung, die E-Ressourcen effizient zu verwalten. Nicht nur Bibliotheken, sondern auch verhandlungsführende Institutionen von Konsortial- und Allianzlizenzen benötigen ein geeignetes Instrument zur Verwaltung von Lizenzinformationen, welches den komplexen Anforderungen moderner E-Ressourcen gerecht wird. Die Deutsche Forschungsgemeinschaft (DFG unterstützt ein Projekt des Hochschulbibliothekszentrums des Landes Nordrhein-Westfalen (hbz, der Universitätsbibliothek Freiburg, der Verbundzentrale des Gemeinsamen Bibliotheksverbundes (GBV und der Universitätsbibliothek Frankfurt, in dem ein bundesweit verfügbares Electronic Ressource Managementsystem (ERMS aufgebaut werden soll. Ein solches ERMS soll auf Basis einer zentralen Knowledge Base eine einheitliche Nutzung von Daten zur Lizenzverwaltung elektronischer Ressourcen auf lokaler, regionaler und nationaler Ebene ermöglichen. Statistische Auswertungen, Rechteverwaltung für alle angeschlossenen Bibliotheken, kooperative Datenpflege sowie ein über standardisierte Schnittstellen geführter Datenaustausch stehen bei der Erarbeitung der Anforderungen ebenso im Fokus wie die Entwicklung eines Daten- und Funktionsmodells. In the last few years the importance of electronic resources in library acquisitions has increased significantly. There has been a shift from mere print holdings to both e- and print combinations and even e-only subscriptions. This shift poses a double challenge for libraries: On the one hand they have to provide their e-resource collections to library users in an appealing way, on the other hand they have to manage these

  13. Vaimueliidi lapsed / Julius Ürt

    Index Scriptorium Estoniae

    Ürt, Julius

    2004-01-01

    Arvustus: Ehin, Kristiina. Luigeluulinn : luuletused. Tallinn : Huma, 2003; [Kaevats, Mihkel] Olematu, Olev. Ederlezi: [luuletused.Tallinn] : Huma, 2003; Viiding, Elo. Teatud erandid : [luuletused]. Tallinn : Tuum, 2003

  14. 2200-IJBCS-Article-Julius Ghogomu

    African Journals Online (AJOL)

    hp

    out at 25 °C in batch mode to evaluate the effects of parameters such as pH, initial phenol concentration and ... model proves that pore diffusion plays little or no significant role in the adsorption of phenol onto .... adsorbents (%R), which is the ratio between ... concentration of phenol, V(L) is the volume of ..... surface area.

  15. 1046-IJBCS-Article-Tieguhong Chupezi Julius

    African Journals Online (AJOL)

    hp

    are coefficients whose values and signs determine the influence of variables on the preference for housing material. P α .... linked to the number of houses constructed. However, the .... ethnicity, gender, household size and number .... Logging companies exploited the five ..... the effects of gender, age, main occupation.

  16. Entwicklung von molekularen Sonden für die sichere Identifizierung von Hefen der Gattungen Brettanomyces, Dekkera

    OpenAIRE

    Röder, Christoph

    2007-01-01

    Hefen der Gattungen Brettanomyces/Dekkera sind in der Produktion von fermentierten Getränken, insbesondere in der Bier-, Sekt- und Weinherstellung bekannt. Sie können als Schädlingshefen insbesondere durch die Bildung von charakteristischen Sekundärmetaboliten zu einer negativen geschmacklichen Veränderung des Getränks führen. Aufgrund ihres langsamen Wachstums werden diese Hefen bei Routineanalysen mit konventionellen Kultivierungsmethoden leicht übersehen. Ein schneller und eindeutiger N...

  17. Von Roll RCP method - first experiences; Von Roll RCP - Verfahren. Erste Erfahrungen

    Energy Technology Data Exchange (ETDEWEB)

    Capitaine, P.; Engweiler, J. [Roll Umwelttechnik AG, Zuerich (Switzerland)

    1998-09-01

    The RCP method was designed as a residue-optimised alternative to the thermally optimised grate firing of residual wastes. Its technical realisation and development to market maturity took no more than 5 years. In the first process stage the waste is converted to high-carbon pyrolysis charcoal and high-rank gas in the absence of oxygen. In the second stage these substances are oxidised by addition of oxygen. The resulting temperature causes the non-combustible constituents of the slag to melt. In a third, optional, stage this molten slag can be liberated of (heavy) metals to such an extent that it can subsequently be used directly as additive for grinding. Further exhaust gas treatment is facilitated by the use of a circulatory fluidised-bed secondary combustion chamber. Despite the reduced flue gas volume and resultant higher pollutant concentrations in the crude gas, overall emissions are lower than in conventional plants. [Deutsch] Das reststoffoptimierte RCP Verfahren ist als Alternative zur thermisch optimierten Rostverbrennung von Restabfaellen konzipiert. In nur fuenf Jahren wurde das Verfahren technisch umgesetzt und zur Marktreife entwickelt. In einer ersten Stufe des Verfahrens wird der Abfall unter Luftabschluss in einen kohlenstoffreichen Pyrolysekoks und eine heizwertreiches Gas umgesetzt. Im zweiten Schritt werden diese Stoffe unter Zugabe von Sauerstoff oxidiert. Dabei treten Temperaturen auf, bei denen die nichtbrennbaren Bestandteile der Schlacke schmelzen. Optional wird diese Schmelzschlacke in einem dritten Schritt derart von (Schwer-) Metallen befreit, dass sie anschliessend direkt als Zement-Zumahlstoff eingesetzt werden kann. Die Nutzung der zirkulierenden Wirbelschicht - Nachbrennkammer zur Abgasbehandlung vereinfacht die weitergehende Abgasbehandlung. Trotz verringertem Rauchgasvolumen und damit hoeheren Schadstoffkonzentrationen im Rohgas werden die Gesamtemissionen gegenueber konventionellen Anlagen verringert. (orig./SR)

  18. Nachhaltigkeit von E-Learning-Innovationen: Von der Pionierphase zur nachhaltigen Implementierung

    Directory of Open Access Journals (Sweden)

    Sabine Seufert

    2003-11-01

    Full Text Available In den letzten Jahren wurden an den meisten Hochschulen im In- und Ausland E-Learning-Projekte in die Wege geleitet. Nach den Projekt- und Impulsprogrammen folgen die Konsolidierungsphasen. Schon während der Projektphasen zeigen sich Problemgruppen, die darauf verweisen, dass E-Learning nicht «nur» eine Angelegenheit der Pädagogik und Didaktik ist. Der erste Teil des Aufsatzes benennt einzelne dieser Problemfelder. Der zweite Teil zeigt auf, dass E-Learning die Hochschulen als Ganzes betrifft, und unterbreitet ein Rahmenkonzept, in dem gezeigt wird, wie die benannten Probleme bei der Implementierung von E-Learning vermieden werden können.

  19. Diskriminierung in der 'longue durée' : von der Notwendigkeit der Kontextualisierung von Strukturproblemen

    OpenAIRE

    2006-01-01

    "Diskriminierung auf der Grundlage von Rasse, Ethnie, Geschlecht, Herkunft, körperlicher Verfassung oder Bildungsniveau ist ein Kennzeichen der westlichen Moderne. Das für moderne Nationalstaaten charakteristische Gewaltmonopol übte nicht nur eine Schutzfunktion in Bezug auf das Leben und Eigentum der Staatsbürger aus, sondern verfügte darüber hinaus über die Definitionsmacht, die Kriterien der Zugehörigkeit zur nationalen Gemeinschaft festlegte und dabei Gewalt gegenüber Nicht-Staatsbürgern ...

  20. Entstehungsbedingungen von Übergängen von der Schule in den Beruf aus qualitativer und quantitativer Perspektive

    Directory of Open Access Journals (Sweden)

    Nora Gaupp

    2013-03-01

    Full Text Available Methodenintegration wird in den Sozialwissenschaften mit dem Argument sich ergänzender Erkenntnismöglichkeiten häufig gefordert. Die vorliegende Analyse zu Übergangswegen von der Schule in Ausbildung und Arbeit von Jugendlichen mit Hauptschulbildung beruht auf Daten einer quantitativen Panelstudie und einer qualitativen Ergänzungsstudie. Aus quantitativer und qualitativer Perspektive wird jeweils ein Einzelfall betrachtet sowie im Rahmen einer Modellbildung eine Verallgemeinerung auf Aggregatebene vorgenommen. Über ein logistisches Regressionsmodell wird die Bedeutung von zentralen individuellen, sozialen und strukturellen Merkmalen wie Schulleistungen, beruflichen Plänen, individuellen Problembelastungen, Migrationshintergrund und Arbeitslosigkeit der Eltern sowie regionaler Arbeitsmarktsituation für den Verlauf von Übergangswegen (Direkteinstieg in Ausbildung, Umweg in Ausbildung über schulische oder berufsvorbereitende Zwischenschritte, fortgesetzter mehrjähriger Schulbesuch und prekäre Wege in Ausbildungslosigkeit untersucht. Über das qualitative Paradigma konnten vier für den Verlauf von Übergängen zentrale Dimensionen identifiziert werden: Agency, Motivation, kritische biografische Ereignisse und soziale Interaktionen. Der Schritt der Modellbildung integriert die vier Erfahrungsebenen und zeigt ihre Bedeutung für Übergänge von der Schule in den Beruf. Die Diskussion fragt nach Möglichkeiten und Grenzen der Erkenntnisentwicklung der beiden Forschungszugänge. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1302126

  1. Richard von Volkmann: surgeon and Renaissance man.

    Science.gov (United States)

    Willy, Christian; Schneider, Peter; Engelhardt, Michael; Hargens, Alan R; Mubarak, Scott J

    2008-02-01

    Richard von Volkmann (1830-1889), one of the most important surgeons of the 19(th) century, is regarded as one of the fathers of orthopaedic surgery. He was a contemporary of Langenbeck, Esmarch, Lister, Billroth, Kocher, and Trendelenburg. He was head of the Department of Surgery at the University of Halle, Germany (1867-1889). His popularity attracted doctors and patients from all over the world. He was the lead physician for the German military during two wars. From this experience, he compared the mortality of civilian and war injuries and investigated the general poor hygienic conditions in civilian hospitals. This led him to introduce the "antiseptic technique" to Germany that was developed by Lister. His powers of observation and creativity led him to findings and achievements that to this day bear his name: Volkmann's contracture and the Hueter-Volkmann law. Additionally, he was a gifted writer; he published not only scientific literature but also books of children's fairy tales and poems under the pen name of Richard Leander, assuring him a permanent place in the world of literature as well as orthopaedics.

  2. Geschichte der Natur bei Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Christian Helmreich

    2009-05-01

    Full Text Available Article in German, Abstracts in English, German and French.This article analyses the importance of an historical view of nature in the works of Alexander von Humboldt. In several of his first writings, Humboldt seems to outline the importance of what one may call history of nature. But even before his famous American travel, his position changed and he became reluctant to accept the seriousness of historical enquiry in the area of natural sciences: if we want to reconstruct the past state of nature, we cannot rely on empirical proofs; and history of nature is therefore necessarily based on uncertain hypotheses. Humboldt kept his sceptical attitude in the first decades of the 19th century, despite the positive results of the palaeontological researches of his scientific colleagues. However, he gradually convinced himself of the scientific interest of historical investigations in the natural sciences. The Cosmos paradoxally displays two apparently conflicting points of view: in his methodological remarks, Humboldt maintains that precise accounts of the past state of nature are out of reach of human knowledge, yet elsewhere in the same Cosmos he gives broad and rather vivid descriptions of the eventful history of nature.

  3. Modellbasierte Steuerung, Regelung und Diagnose von Brennstoffzellenantrieben

    Science.gov (United States)

    Bußhardt, Joachim; Baaser, Bernhard; Formanski, Volker; Schäfer, Sascha; Sinsel, Stefan

    Steigende Bevölkerungszahlen und damit zunehmender Energiebedarf stellen eine große Herausforderung für Menschheit und Umwelt dar. Mit steigendem Wohlstand ist auch ein stärkeres Bedürfnis nach Mobilität und damit ein höherer Energieverbrauch verbunden. Die derzeitigen enormen Steigerungen des Bruttoinlandsproduktes in China und Indien - zwei Ländern, die zusammen mehr als ein Drittel der Weltbevölkerung stellen - lassen auch zukünftig ungebrochene Steigerungen des Weltenergieverbrauches erwarten. Dies gilt für alle Bereiche, besonders aber für den Verkehrssektor. Letzterer stellt mit seinem signifikanten Anteil am Energieverbrauch sowie den damit einhergehenden Emissionen und seinem hohen Wachstumspotenzial ein besonderes Handlungsfeld dar. Insbesondere wegen der in diesem Sektor zu erwartenden ansteigenden CO2-Emissionen stehen Effizienzverbesserungen und die Entwicklung alternativer Antriebe im Vordergrund. Dabei spielt die Brennstoffzelle als Fahrzeugantrieb eine entscheidende Rolle, da sie einen hohen Systemwirkungsgrad mit fehlenden CO2- und Schadstoffemissionen verbindet. Wegen der hohen Komplexität sind dabei moderne Steuerungs-, Regelungs- und Diagnoseverfahren von besonderer Bedeutung, auf die in diesem Beitrag näher eingegangen wird. Neben einigen grundlegenden Konzepten wird an Hand zweier Beispiele das Potenzial modellgestützter Methoden aufgezeigt.

  4. Zur Struktur und Funktion von Synonymen

    Directory of Open Access Journals (Sweden)

    Marina Zorman

    1998-12-01

    Full Text Available Der Artikel behandelt die Synonyme im Licht der funktionell-strukturellen Sprachtheorie Coserius. 1 Die Wahl der theoretischen Grundsätze wurde durch die Festellung diktiert, daß die bisherigen Erkenntnisse über die Synonymie widersprüchlich sind und daß auch schon über alle Feststellungen berechtigte Einsprüche erhoben wurden. Deshalb wird in dieser Arbeit auf der genannten theoretischen Grundlage, die verschiedene Gesichtspunkte des Problems verbindet, anstatt sie zu trennen (s. Punkt 2, ein Modell für die Analyse von Synonymen vorgestellt (3, das die klassischen Schwächen der Semantikforschung (zu geringe Menge tatsächlicher Daten, Subjektivität und Introspektion durch eine empirische Untersuchung in einem Textkorpus zu ersetzen versucht. In die Analyse sind drei Inhaltsebenen einbezogen (Bezeichnung, Bedeutung und Sinn und ihnen sind jeweils entsprechende Untersuchungsmethoden zugeordnet. Im Sinne des Modells wurden in der Arbeit Zorman 1997 zwei slowenische Synonympaare (kuverta - ovojnica und borba - boj analysiert, die als Beispiele reiner (und totaler Synonymie gelten können. Die Analyse wird aus Platzgründen an dieser Stelle nicht detailliert dargestellt,2 veranschaulicht werden nur ihre Tragweite und die Ergebnisse (4. Im letzten Teil (5 werden die Leistungen der vorgeschlagenen Methode bewertet und einige Annahmen dargestellt, die der weiteren Erforschung der Synonyme dienen könnten. Die objektive Behandlung der Synonymie unter unterschiedlichen Gesichtspunkten scheint einige Dogmen über Synonyme in Frage zu  stellen.

  5. Eine Frau in der Kultur, die Kultur einer Frau: Caroline von Humboldt. A woman in the culture, the culture of a woman: Caroline von Humboldt

    Directory of Open Access Journals (Sweden)

    Elžbieta M. Kowalska

    2008-01-01

    Full Text Available The subject of this presentation is Wilhelm von Humboldt’s wife, Alexander von Humboldt’s sisterin-law, a close female friend of Lotte Schiller and of her sister, Caroline von Wolzogen, held in high regard by Goethe, admired by Schiller, the former Fräulein von Dacheröden from Erfurt, the future Caroline von Humboldt. She was the ancestress of one of the most respected and best German noble families, a mother of eight children, an intellectually gifted woman, in which the German ideals of femininity were fulfilled, who knew to lead the salons and to talk about arts and literature.

  6. [Determination of von Willebrand factor multimers in Mexican population].

    Science.gov (United States)

    Hernández-Zamora, Edgar; Zavala-Hernández, Cesar; Viveros-Sandoval, Martha Eva; Ochoa-Rico, Angeles; Martínez-Murillo, Carlos; Reyes-Maldonado, Elba

    2014-01-01

    Antecedentes: la enfermedad de von Willebrand es un padecimiento hereditario en el que la estructura, función y concentración del factor de von Willebrand están alteradas y, en consecuencia, también la interacción plaqueta-factor de von Willebrand-endotelio. En México no hay registros epidemiológicos de la enfermedad, sólo se han efectuado algunos estudios aislados desde el punto de vista clínico y hematológico. Material y métodos: estudio retrospectivo efectuado en 155 mexicanos mestizos, 75 de ellos con diagnóstico presuntivo de enfermedad de von Willebrand, 15 con sospecha de hemofilia A y 65 donadores sanos (testigos). Se realizaron pruebas: básicas de coagulación, especiales y de clasificación: análisis de la composición multimérica. Resultados: 15 pacientes se diagnosticaron con hemofilia A; de los 75 sujetos con sospecha de enfermedad de von Willebrand se diagnosticaron 50 de la manera siguiente: tipo 1 (62%), tipo 2 (22%) [subtipos: 2A (14%), 2B (2%) y 2N (6%)] y tipo 3 (16%). Conclusión: el análisis de los multímeros del factor de von Willebrand es un método que cumple con las características adecuadas para el diagnóstico de la enfermedad de von Willebrand, por lo que es necesario implementar esta metodología para su estudio y mejorar su diagnóstico específico.

  7. Molecular analysis of HEXA gene in Argentinean patients affected with Tay-Sachs disease: possible common origin of the prevalent c.459+5A>G mutation.

    Science.gov (United States)

    Zampieri, Stefania; Montalvo, Annalisa; Blanco, Mariana; Zanin, Irene; Amartino, Hernan; Vlahovicek, Kristian; Szlago, Marina; Schenone, Andrea; Pittis, Gabriela; Bembi, Bruno; Dardis, Andrea

    2012-05-15

    Tay-Sachs disease (TSD) is a recessively inherited disorder caused by the deficient activity of hexosaminidase A due to mutations in the HEXA gene. Up to date there is no information regarding the molecular genetics of TSD in Argentinean patients. In the present study we have studied 17 Argentinean families affected by TSD, including 20 patients with the acute infantile form and 3 with the sub-acute form. Overall, we identified 14 different mutations accounting for 100% of the studied alleles. Eight mutations were novel: 5 were single base changes leading to drastic residue changes or truncated proteins, 2 were small deletions and one was an intronic mutation that may cause a splicing defect. Although the spectrum of mutations was highly heterogeneous, a high frequency of the c.459+5G>A mutation, previously described in different populations was found among the studied cohort. Haplotype analysis suggested that in these families the c.459+5G>A mutation might have arisen by a single mutational event.

  8. Prader-Willi syndrome and Tay-Sachs disease in association with mixed maternal uniparental isodisomy and heterodisomy 15 in a girl who also had isochromosome Xq.

    Science.gov (United States)

    Zeesman, Susan; McCready, Elizabeth; Sadikovic, Bekim; Nowaczyk, Małgorzata Jm

    2015-01-01

    Malsegregation of chromosomes during reproduction can result in uniparental disomy when associated with trisomy rescue, monosomy rescue or gamete complementation. Pathogenicity stemming from uniparental disomy in liveborns results from imprinting disorders or autozygosity for autosomal recessive disorders. We report on a girl with Prader-Willi syndrome and Tay-Sachs disease resulting from maternal uniparental disomy of chromosome 15. The child also had an isochromosome Xq. To further characterize the etiology of the aberrant chromosome 15 and the isochromosome Xq, SNP loci from both chromosomes were assessed in the proband and parents, and genome-wide DNA methylation analysis was performed. SNP and DNA methylation analysis confirmed maternal uniparental heterodisomy around the Prader-Willi locus, while the region around the HEXA locus showed maternal uniparental isodisomy. This result is consistent with trisomy rescue of a maternal meiosis l error in a chromosome 15 with two meiotic recombinations. SNP analysis of the X chromosomes is consistent with a maternal origin for the isochromosome. © 2014 Wiley Periodicals, Inc.

  9. Locally Compact Quantum Groups. A von Neumann Algebra Approach

    Science.gov (United States)

    Van Daele, Alfons

    2014-08-01

    In this paper, we give an alternative approach to the theory of locally compact quantum groups, as developed by Kustermans and Vaes. We start with a von Neumann algebra and a comultiplication on this von Neumann algebra. We assume that there exist faithful left and right Haar weights. Then we develop the theory within this von Neumann algebra setting. In [Math. Scand. 92 (2003), 68-92] locally compact quantum groups are also studied in the von Neumann algebraic context. This approach is independent of the original C^*-algebraic approach in the sense that the earlier results are not used. However, this paper is not really independent because for many proofs, the reader is referred to the original paper where the C^*-version is developed. In this paper, we give a completely self-contained approach. Moreover, at various points, we do things differently. We have a different treatment of the antipode. It is similar to the original treatment in [Ann. Sci. & #201;cole Norm. Sup. (4) 33 (2000), 837-934]. But together with the fact that we work in the von Neumann algebra framework, it allows us to use an idea from [Rev. Roumaine Math. Pures Appl. 21 (1976), 1411-1449] to obtain the uniqueness of the Haar weights in an early stage. We take advantage of this fact when deriving the other main results in the theory. We also give a slightly different approach to duality. Finally, we collect, in a systematic way, several important formulas. In an appendix, we indicate very briefly how the C^*-approach and the von Neumann algebra approach eventually yield the same objects. The passage from the von Neumann algebra setting to the C^*-algebra setting is more or less standard. For the other direction, we use a new method. It is based on the observation that the Haar weights on the C^*-algebra extend to weights on the double dual with central support and that all these supports are the same. Of course, we get the von Neumann algebra by cutting down the double dual with this unique

  10. Entwicklungsperspektiven von Social Software und dem Web 2.0

    Science.gov (United States)

    Raabe, Alexander

    Der Artikel beschäftigt sich zunächst mit dem derzeitigen und zukünftigen Einsatz von Social Software in Unternehmen. Nach dem großen Erfolg von Social Software im Web beginnen viele Unternehmen eigene Social Software-Initiativen zu entwickeln. Der Artikel zeigt die derzeit wahrgenommenen Einsatzmöglichkeiten von Social Software im Unternehmen auf, erörtert Erfolgsfaktoren für die Einführung und präsentiert mögliche Wege für die Zukunft. Nach der Diskussion des Spezialfalles Social Software in Unternehmen werden anschließend die globalen Trends und Zukunftsperspektiven des Web 2.0 in ihren technischen, wirtschaftlichen und sozialen Dimensionen dargestellt. Wie aus den besprochenen Haupttrends hervorgeht, wird die Masse an digital im Web verfügbaren Informationen stetig weiterwachsen. So stellt sich die Frage, wie es in Zukunft möglich sein wird, die Qualität der Informationssuche und der Wissensgenerierung zu verbessern. Mit dem Einsatz von semantischen Technologien im Web wird hier eine revolutionäre Möglichkeit geboten, Informationen zu filtern und intelligente, gewissermaßen verstehende" Anwendungen zu entwerfen. Auf dem Weg zu einem intelligenten Web werden sich das Semantic Web und Social Software annähern: Anwendungen wie Semantic Wikis, Semantic Weblogs, lightweight Semantic Web-Sprachen wie Microformats oder auch kommerzielle Angebote wie Freebase von Metaweb werden die ersten Vorzeichen einer dritten Generation des Webs sein.

  11. Acquired von Willebrand syndrome: A rare disorder of heterogeneous etiology

    Directory of Open Access Journals (Sweden)

    P Kasatkar

    2013-01-01

    Full Text Available Context: Acquired von Willebrand syndrome (AVWS is a rare bleeding disorder that mimics the inherited form of von Willebrand disease (VWD in terms of laboratory findings and clinical presentation. Aims: To study the etiology of acquired VWD. Settings and Design: The patients referred from various hospitals in and out of Mumbai were included in the study. Materials and Methods: Six patients with AVWS diagnosed at this center over the last 10 years were analyzed against 171 patients with inherited VWD. The differential diagnosis of AVWS was made based on reduced levels of von Willebrand antigen and von Willebrand ristocetin cofactor, decrease in ristocetin induced platelet aggregation, absence of correction in mixing studies with no prior history of bleeding problems and a negative family history for bleeding disorders. Results: In three patients, the disease was associated with systematic lupus erythematosus, out of which one was also associated with Kikuchi lymphadenitis and second with autoimmune hemolytic anemia. Fourth case was associated with hypothyroidism and fifth was a case of dermatitis and vitiligo. The last patient was a case of hemophilia A with Burkitts lymphoma, who developed autoantibodies to von Willebrand factor. Except two patients, all other patients responded to immune suppressive therapy with corticosteroids, while the patient with hypothyroidism responded to oral thyroxine. Conclusion: AVWS is a rare condition and may often be missed or diagnosed as inherited disease associated with heterogeneous disease conditions.

  12. Proof of pipeline strength based on measurements of inspection pigs; Festigkeitsnachweis von Pipelines aufgrund der Messergebnisse von Pruefmolchen

    Energy Technology Data Exchange (ETDEWEB)

    De la Camp, H.J.; Feser, G.; Hofmann, A.; Wolf, B.; Schmidt, H. [TUeV Sueddeutschland Bau und Betrieb GmbH, Muenchen (Germany); Herforth, H.E.; Juengling, K.H.; Schmidt, W. [TUeV Anlagentechnik GmbH, Berlin-Schoeneberg (Germany). Unternehmensgruppe TUeV Rheinland/Berlin-Brandenburg

    2002-01-01

    The report is aimed at collecting and documenting the state of the art and the extensive know how of experts and pipeline operators with regard to judging the structural integrity of pipelines. In order to assess the actual mechanical strength of pipelines based on measurement results obtained by inspection pigs, guidance is given for future processing, which eventually can be used as a basis for an industry standard. A literature study of the commercially available types of inspection pigs describes and synoptically lists the respective pros and cons. In essence the report comprises besides check lists of operating data for the pipeline and the pig runs mainly the evaluation of defects and respective calculating procedures. Included are recommendations regarding maintenance planning, verification of defects as well as repetition of pig runs. (orig.) [German] Ziel des Berichtes ist die Erfassung und Dokumentation zum derzeitigen Stand der Technik und des vorhandenen umfangreichen Know-how von Sachverstaendigen und Pipelinebetreibern auf dem Gebiet der sicherheitstechnischen Beurteilung von Pipelines. Fuer den Festigkeitsnachweis von Pipelines aufgrund der Messergebnisse von Pruefmolchen wurde ein Leitfaden als Basis fuer die zukuenftige Vorgehensweise erstellt, der eventuell die Grundlage eines normativen Regelwerkes bilden kann. In einer Literaturstudie wurden die auf dem Markt befindlichen Pruefmolchtypen zusammenfassend beschrieben und ihre Vor- und Nachteile tabellarisch gegenuebergestellt und bewertet. Neben der Erstellung von Checklisten fuer notwendige Daten zum Betrieb der Pipeline und der Molchlaeufe bildet die Fehlerbewertung mit entsprechenden Berechnungsverfahren den Hauptteil dieses Berichtes. Hinweise zur Instandhaltungsplanung (Fehlerverifikation und Molchlaufwiederholung) werden gegeben. (orig.)

  13. Applikation von fermentierter Soja bei Krebspatienten zur Verminderung von Kachexie und Erhöhung der Apoptose - eine prospektive Pilotstudie

    Directory of Open Access Journals (Sweden)

    Jacob U

    2009-01-01

    Full Text Available Kachexie ist eine Begleiterkrankung von Krebs, Aids oder rheumatoider Arthritis. Andere Symptome dieser Erkrankungen sind Depression sowie chronische Erschöpfung. Für alle diese Begleiterkrankungen, die die Lebensqualität der schwererkrankten Patienten negativ beeinflussen, wird eine Erhöhung von Entzündungsmediatoren (z.B. IL-6 und TNF-α verantwortlich gemacht. Für Krebs wird eine Erniedrigung der Apoptose, ausgelöst durch eine Erhöhung von NFκB verantwortlich gemacht. Eine Gabe eines fermentierten Soja-Produktes, das in den USA seit 10 Jahren zur Verbesserung der Lebensqualität von Krebspatienten eingesetzt wird, wurde in einer prospektiven Studie untersucht: Für je 5 Patienten, die unter Prostata-, Ovar- oder Brustkrebs litten, konnte eine signifikante Verminderung von Kachexie, Stress und Depression festgestellt werden. Gleichzeitig konnte man für Prostata- und Ovarkrebs-Patienten eine Erhöhung der Genexpression apoptotischer Marker disseminierter Tumorzellen feststellen. Zusätzlich wurde eine starke Erhöhung der Genexpression des Tumorsuppressorgens p21 festgestellt. Auch wenn die prospektive Studie präliminär ist und die Anzahl der untersuchten Patienten zu klein, so widerspricht sie nicht unserer Annahme, dass es einen direkten Zusammenhang zwischen Krebs und Begleiterkrankungen, besonders der Kachexie, gibt.

  14. Asymptotic structure of free product von Neumann algebras

    Science.gov (United States)

    Houdayer, Cyril; Ueda, Yoshimichi

    2016-11-01

    Let $(M, \\varphi) = (M_1, \\varphi_1) \\ast (M_2, \\varphi_2)$ be the free product of any $\\sigma$-finite von Neumann algebras endowed with any faithful normal states. We show that whenever $Q \\subset M$ is a von Neumann subalgebra with separable predual such that both $Q$ and $Q \\cap M_1$ are the ranges of faithful normal conditional expectations and such that both the intersection $Q \\cap M_1$ and the central sequence algebra $Q' \\cap M^\\omega$ are diffuse (e.g. $Q$ is amenable), then $Q$ must sit inside $M_1$. This result generalizes the previous results of the first named author in [Ho14] and moreover completely settles the questions of maximal amenability and maximal property Gamma of the inclusion $M_1 \\subset M$ in arbitrary free product von Neumann algebras.

  15. Renaturierung von subalpinen und alpinen Ökosystemen

    Science.gov (United States)

    Krautzer, B.; Klug, Brigitte

    Die große Vielfalt an alpinen und subalpinen Ökosystemen auf waldfreien Standorten stellt besonders hohe Anforderungen an Planung und Durchführung von Renaturierungsmaßnahmen. Zunehmende Meereshöhe, starke Hangneigungen und extreme klimatische Verhältnisse im Gebirge bedingen zudem seit jeher natürliche Erosionsprozesse. Die zahllosen menschlichen Aktivitäten der letzten Jahrzehnte, gepaart mit unzureichenden Begrünungsmaßnahmen, erhöhen dieses Risiko noch um ein Vielfaches: Geländekorrekturen im Zuge von Skipistenbauten, Almrevitalisierungen, Forst- und Almwegebauten, Maßnahmen zur Verbesserung der touristischen Infrastruktur oder Wildbach- und Lawinenverbauungen. Nur durch Verwendung von hochwertigem, dem Standort angepasstem Pflanzen-oder Saatgutmaterial in Kombination mit der passenden Begrünungstechnik kann dieser Bedrohung dauerhaft entgegengewirkt werden. Dabei sind folgende limitierende Faktoren besonders zu beachten.

  16. Zur Relevanz von sozialer Ungleichheit im Kontext der Mediensozialisationsforschung

    Directory of Open Access Journals (Sweden)

    Ingrid Paus-Hasebrink

    2009-05-01

    Full Text Available Ziel des vorliegenden Beitrags ist es, deutlich zu machen, dass Mediensozialisations­forschung nicht ohne den Blick auf die Lebenswelt Heranwachsender auskommen kann; diese wird geprägt vom sozialen Milieu (einer Manifestation des je spezifischen Zusammenhangs von sozialer Lage und Lebensentwurf der agierenden Personen, in dessen Rahmen sich das Aufwachsen von Kindern und Jugendlichen vollzieht. Seine spezifischen Konstellationen, zu denen auch die Medienumgangsweisen gehören, müssen daher in die Forschung miteinbezogen werden. Um die Bedeutung, die Mediensymbolik im Alltag von Heranwachsenden einnimmt, im Kontext untersuchen zu können, erscheint eine integrative sowie interdisziplinäre Forschung notwendig. Als Beispiel dafür wird eine Panelstudie zur (Medien-Sozialisation bei sozial benachteiligten Kindern in Österreich in ihrer theoretischen und methodologischen Anlage vorgestellt.

  17. Flexibilitätsbasierte Gestaltung der logistischen Auftragsabwicklung – Anwendung am Beispiel von Produktionsdienstleistern

    OpenAIRE

    Teich, Enrico

    2014-01-01

    Zur Bewältigung von Belastungsschwankungen in der industriellen Produktion – der systematischen Regelung von Kapazitätsangebot und -bedarf – existieren Methoden in der logistischen Auftragsabwicklung, deren Anwendungserfolg von den im Produktionsbereich vorhandenen Kapazitäts- und Belastungsflexibilitätsmaß abhängig ist. Die Entwicklung geeigneter Verfahren zur Messung dieser Flexibilitätstypen als auch von Ansätzen zur Nutzung der Messwerte bei der Gestaltung der logistischen Auftragsabwickl...

  18. Handgeführter Endeffektor für die automatisierte Handhabung von textilen Zuschnitten

    OpenAIRE

    Braun, Georg; Buchheim, Andreas; Gerngroß, Tobias

    2013-01-01

    Ein typischer Herstellungsprozess von CFK-Bauteilen erfordert die präzise und wiederholbare Handhabung von trockenen, textilen Halbzeugen, was derzeit vorwiegend durch manuelle Prozesse erfolgt. Für die Automatisierung dieser Arbeitsschritte wurden am Zentrum für Leichtbauproduktionstechnologie in Augsburg zwei Generationen von Endeffektoren entwickelt. Anwendungsszenarien stellten die Ablage von Textilien für einfach und doppelt gekrümmte Bauteilgeometrien dar. Diese Arbeit be...

  19. Screening for von Willebrand disease: contribution of an automated assay for von Willebrand factor activity.

    Science.gov (United States)

    Lasne, D; Dey, C; Dautzenberg, M-D; Cherqaoui, Z; Monge, F; Aouba, A; Torchet, M-F; Geloen, D; Landais, P; Rothschild, C

    2012-05-01

    Measuring von Willebrand factor (VWF) activity is essential to the diagnosis of von Willebrand disease (VWD). The VWF activity is usually assessed based on measurement of the ristocetin cofactor (VWF:RCo). However, that test is technically challenging and has high intra- and inter-assay variabilities. The HemosIL VWF activity (VWF:AC) is a fully automated assay, recently proposed as a good alternative to VWF:RCo for VWD diagnosis. This study was undertaken to assess this new method. First, the analytical performance of VWF:AC on an automated coagulo-meter (ACLTop) was determined, and then this new method was compared with VWF:RCo and the platelet function analyzer (PFA100) for 160 patients referred for VWD screening. The VWF:AC achieved acceptable precision with within-run and between-run coefficients of variation ranging from 2.3% to 14.1%, and linearity from 10% to 100%. Despite some marked differences between VWF:AC and VWF:RCo for 10 plasmas tested, their agreement for VWD diagnosis was good. The VWF:AC had sensitivity similar to that of PFA100 (close to 100%), but better specificity (97.7% vs. 66% or 60%, depending on the cartridge used). The good analytical performance, and the sensitivity and specificity of VWF:AC to detect VWF deficiency renders it a suitable method for VWD screening. Our findings support VWF:AC use for the diagnostic work-up of VWD, paying close attention to concomitant clinical signs and bleeding score, as recommended for VWD. © 2011 Blackwell Publishing Ltd.

  20. Die Bundesstatistik als Anbieter und Nutzer von raumbezogenen Daten

    Directory of Open Access Journals (Sweden)

    R. Humbel

    Einige konkrete und potentielle Anwendungen der vorhandenen Daten sollen das Potential und die Breite der Fragestellungen, die damit angegangen werden können, illustrieren. Eine besondere Stellung dürfte in Zukunft aber auch die Satellitenfernerkundung erhalten, deren Daten und Auswertungen eine willkommene Ergänzung für die eher traditionellen GIS-Datensätze bilden werden. Ein erster Pilotversuch wurde vor wenigen Monaten im BFS gestartet, der zum Ziel hat, die Machbarkeit einer gesamtschweizerischen Unterscheidung von Laub-, Nadel- und Mischwald als Ergänzung der auf der Grundlage von konventionellen Luftbildern erhobenen Arealstatistik nachzuweisen.

  1. IT und Kommunikationstechnologien dominieren die Freizeit von Jugendlichen

    OpenAIRE

    Bohmann, Sandra; Schupp, Jürgen

    2016-01-01

    Jugendliche gestalten ihre Freizeit heute deutlich anders als noch vor fünfzehn Jahren. Die Nutzung von Informations- und Kommunikationstechnologien ist zur bedeutendsten Freizeitbeschäftigung für sie geworden. Auf repräsentativer statistischer Basis lässt sich anhand von Daten der Längsschnittstudie Sozio-oekonomisches Panel (SOEP) belegen, dass Internet- und PC-bezogene Freizeitbeschäftigungen heute für über 95 Prozent aller 17-Jährigen eine wichtige Rolle spielen, ungeachtet des Geschlecht...

  2. Comparison of automated von Willebrand factor activity assays

    DEFF Research Database (Denmark)

    Timm, Annette; Hillarp, Andreas; Philips, Malou

    2015-01-01

    activity/antigen ratios in samples classified as having VWD (activity classification power might interfere with the interpretation......INTRODUCTION: Von Willebrand Disease (VWD) is the most common inherited bleeding disorder. Measurement of von Willebrand factor (VWF) activity in plasma is often based on platelet agglutination stimulated by the ristocetin cofactor activity. Novel assays, based on latex beads with recombinant...... glycoprotein Ib instead of platelets, have recently been developed but it is unclear whether these can improve the diagnostic capability for VWD. AIM: To compare four automated VWF activity methods in a mixed population of patients referred for evaluation of bleeding tendency. METHODS: The analytical...

  3. Unterstützung von Lerngemeinschaften in verteilten intelligenten Lehrsystemen

    OpenAIRE

    Harrer, Andreas Georg

    2007-01-01

    Intelligente Lehrsysteme (ILS) ermöglichen einzelnen Lernern einen dem individuellen Kenntnisstand und Eigenschaften angepassten rechnergestützten Unterricht. Lernen in Gruppen bietet zusätzlich die Möglichkeit zur Einübung sozialer Fähigkeiten und zur flexiblen Gestaltung von Lernformen. Bisherige Ansätze von Gruppenlernsystemen stellen eine verteilte Lernumgebung zur Verfügung, durch die eine Zusammenarbeit räumlich oder zeitlich verteilter Studenten ermöglicht wird, ohne jedoch die charakt...

  4. Moyal's Characteristic Function, the Density Matrix and von Neumann's Idempotent

    OpenAIRE

    Hiley, Basil J.

    2014-01-01

    In the Wigner-Moyal approach to quantum mechanics, we show that Moyal's starting point, the characteristic function $M(\\tau,\\theta)=\\int \\psi^{*}(x)e^{i(\\tau {\\hat p}+\\theta{\\hat x})}\\psi(x)dx$, is essentially the primitive idempotent used by von Neumann in his classic paper "Die Eindeutigkeit der Schr\\"odingerschen Operatoren". This paper provides the original proof of the Stone-von Neumann equation. Thus the mathematical structure Moyal develops is simply a re-expression of what is at the h...

  5. Weibel-Palade bodies: a window to von Willebrand disease.

    Science.gov (United States)

    Valentijn, K M; Eikenboom, J

    2013-04-01

    Weibel-Palade bodies (WPBs) are the storage organelles for von Willebrand factor (VWF) in endothelial cells. VWF forms multimers that assemble into tubular structures in WPBs. Upon demand, VWF is secreted into the blood circulation, where it unfolds into strings that capture platelets during the onset of primary hemostasis. Numerous mutations affecting VWF lead to the bleeding disorder von Willebrand disease. This review reports the recent findings on the effects of VWF mutations on the biosynthetic pathway of VWF and its storage in WPBs. These new findings have deepened our understanding of VWF synthesis, storage, secretion, and function.

  6. Politische Bildung im Kontext von Regierung, Unterricht und Zucht

    OpenAIRE

    Thomas Rucker

    2014-01-01

    Johann Friedrich Herbart (1776-1841) gilt als der Begründer der wissenschaftlichen Pädagogik. In diesem Beitrag wird zu zeigen versucht, dass Herbart die Unterstützung politischer Bildung als eine Aufgabe von Regierung, Unterricht und Zucht bestimmt und in seinem Werk wichtige „Bausteine“ für eine Theorie der politischen Bildung unter den Bedingungen von Erziehung vorlegt hat. Nach Herbart ist das politische Selbst- und Weltverhältnis auf Sachverhalte bezogen, die nicht nur die Lebensführung ...

  7. The smooth entropy formalism for von Neumann algebras

    Energy Technology Data Exchange (ETDEWEB)

    Berta, Mario, E-mail: berta@caltech.edu [Institute for Quantum Information and Matter, California Institute of Technology, Pasadena, California 91125 (United States); Furrer, Fabian, E-mail: furrer@eve.phys.s.u-tokyo.ac.jp [Department of Physics, Graduate School of Science, University of Tokyo, Tokyo, Japan and Institute for Theoretical Physics, Leibniz University Hanover, Hanover (Germany); Scholz, Volkher B., E-mail: scholz@phys.ethz.ch [Institute for Theoretical Physics, ETH Zurich, Zurich (Switzerland)

    2016-01-15

    We discuss information-theoretic concepts on infinite-dimensional quantum systems. In particular, we lift the smooth entropy formalism as introduced by Renner and collaborators for finite-dimensional systems to von Neumann algebras. For the smooth conditional min- and max-entropy, we recover similar characterizing properties and information-theoretic operational interpretations as in the finite-dimensional case. We generalize the entropic uncertainty relation with quantum side information of Tomamichel and Renner and discuss applications to quantum cryptography. In particular, we prove the possibility to perform privacy amplification and classical data compression with quantum side information modeled by a von Neumann algebra.

  8. Dr. Space the life of Wernher von Braun

    CERN Document Server

    Ward, Bob

    2013-01-01

    Written by veteran aerospace journalist Bob Ward, who spent years investigating his subject, this biography presents a revealing but even-handed portrait of the father of modern rocketry. As he chronicles Wernher von Braun's life, Ward explodes many myths and misconceptions about the controversial genius who was a hero to some, a villain to others. The picture of von Braun that emerges is of a brilliant scientist with limitless curiosity and a drive to achieve his goals at almost any price from, developing the world's first ballistic missile used against the Allies in World War II to help

  9. KK -theory and spectral flow in von Neumann algebras

    DEFF Research Database (Denmark)

    Kaad, Jens; Nest, Ryszard; Rennie, Adam

    2012-01-01

    We present a definition of spectral flow for any norm closed ideal J in any von Neumann algebra N. Given a path of selfadjoint operators in N which are invertible in N/J, the spectral flow produces a class in Ko (J). Given a semifinite spectral triple (A, H, D) relative to (N, t) with A separable......, we construct a class [D] ¿ KK1 (A, K(N)). For a unitary u ¿ A, the von Neumann spectral flow between D and u*Du is equal to the Kasparov product [u] A[D], and is simply related to the numerical spectral flow, and a refined C* -spectral flow....

  10. Bildnisse mit Berg: Goethe und Alexander von Humboldt

    Directory of Open Access Journals (Sweden)

    Renato Giuseppe Mazzolini

    2004-04-01

    Full Text Available Article in German, translated by Wolfgang Böker, Abstracts in English and GermanBoth Alexander von Humboldt and Johann Wolfgang von Goethe have been portrayed in their later years anachronistically before the background of a mountain that had been of high significance in their earlier biography and carreer. For Goethe this was the Vesuvio, and for Humboldt the Chimborazo. This paper examines the numerous conceptual and formal parallels between the two paintings which make it probable that the Goethe portrait served as a blueprint for the portrait of Humboldt.

  11. Kryoballon-Pulmonalvenenisolation zur Behandlung von paroxysmalem Vorhofflimmern

    Directory of Open Access Journals (Sweden)

    Fürnkranz A

    2010-01-01

    Full Text Available Die vollständige elektrische Isolation der Pulmonalvenen vom Vorhofmyokard mittels Katheterablation wird mit weltweit zunehmender Häufigkeit zur Behandlung von Vorhofflimmern eingesetzt. Die vorherrschende Ablationsstrategie besteht in der Anlage zirkumferenzieller Läsionen um die rechten und linken Pulmonalvenenostien unter Verwendung von Hochfrequenzstrom. Aufgrund der hohen technischen Ansprüche, welche diese Prozedur an den interventionellen Rhythmologen stellt, wurde mit der Kryoballon-Technologie ein Verfahren entwickelt, welches die Pulmonalvenenisolation mit einer oder wenigen Energie-Applikationen ermöglicht. Vor- und Nachteile dieser relativ jungen Technologie werden in dieser Übersicht im Vergleich zum Standardverfahren dargestellt.

  12. Eine einfache Synthese von a-Styrylenolethern und Arylacetaldehyden aus Benzylalkoholen

    OpenAIRE

    1982-01-01

    Die Umsetzung von Benzylalkohol in Dimethylsulfoxid mit Kaliumhydroxid unter Bildung von (E)--(Benzyloxy)styrol (1a) wird beschrieben. Für diese Reaktion wird ein Mechanismus vorgeschlagen, der durch Isotopenmarkierung und Einsatz von Zwischenstufen belegt wird. Die Reaktion wird zu einer präparativen Methode für die Homologisierung aromatischer Aldehyde zu Aryl-acetaldehyden bzw. ihren Enolethern ausgebaut.

  13. Die grossen Physiker und ihre Entdeckungen von den fallenden Körpern zu den Quarks

    CERN Document Server

    Segrè, Emilio

    1998-01-01

    Von Galileo Galilei bis zu Richard Feynman und Murray Gell-Mann - von den fallenden Körpern zu den Quarks: Der Physiknobelpreisträger Emilio Segre hat seine ganz persönliche Geschichte der Physik geschrieben. Er erzählt von den großen Gestalten und deren wichtigen Entdeckungen mit großer Anschaulichkeit und Lebendigkeit.

  14. Muuga / Mary von Grünewaldt ; tõlk. Mati Sirkel

    Index Scriptorium Estoniae

    Grünewaldt, Mary von

    2004-01-01

    Leo Zoegelt ostetud Muuga mõisahoone korrastamisest ja uue hoone ehitamisest C. T. von Neffi kunstikogu paigutamise tarbeks. Tütre mälestused. Tõlgitud raamatust: Skizzen und Bilder aus dem Leben Carl Timoleon von Neff / Mary von Grünewaldt. Darmstadt, 1887

  15. Muuga / Mary von Grünewaldt ; tõlk. Mati Sirkel

    Index Scriptorium Estoniae

    Grünewaldt, Mary von

    2004-01-01

    Leo Zoegelt ostetud Muuga mõisahoone korrastamisest ja uue hoone ehitamisest C. T. von Neffi kunstikogu paigutamise tarbeks. Tütre mälestused. Tõlgitud raamatust: Skizzen und Bilder aus dem Leben Carl Timoleon von Neff / Mary von Grünewaldt. Darmstadt, 1887

  16. Von-Neumann and Beyond: Memristor Architectures

    KAUST Repository

    Naous, Rawan

    2017-05-01

    An extensive reliance on technology, an abundance of data, and increasing processing requirements have imposed severe challenges on computing and data processing. Moreover, the roadmap for scaling electronic components faces physical and reliability limits that hinder the utilization of the transistors in conventional systems and promotes the need for faster, energy-efficient, and compact nano-devices. This work thus capitalizes on emerging non-volatile memory technologies, particularly the memristor for steering novel design directives. Moreover, aside from the conventional deterministic operation, a temporal variability is encountered in the devices functioning. This inherent stochasticity is addressed as an enabler for endorsing the stochastic electronics field of study. We tackle this approach of design by proposing and verifying a statistical approach to modelling the stochastic memristors behaviour. This mode of operation allows for innovative computing designs within the approximate computing and beyond Von-Neumann domains. In the context of approximate computing, sacrificing functional accuracy for the sake of energy savings is proposed based on inherently stochastic electronic components. We introduce mathematical formulation and probabilistic analysis for Boolean logic operators and correspondingly incorporate them into arithmetic blocks. Gate- and system-level accuracy of operation is presented to convey configurability and the different effects that the unreliability of the underlying memristive components has on the intermediary and overall output. An image compression application is presented to reflect the efficiency attained along with the impact on the output caused by the relative precision quantification. In contrast, in neuromorphic structures the memristors variability is mapped onto abstract models of the noisy and unreliable brain components. In one approach, we propose using the stochastic memristor as an inherent source of variability in

  17. Diagnosis and classification of von Willebrand disease: a review of the differential utility of various functional von Willebrand factor assays.

    Science.gov (United States)

    Favaloro, Emmanuel J

    2011-10-01

    von Willebrand disease (VWD) is considered to be the most common inherited bleeding disorder. VWD is diagnosed following a clinical and physical review, with personal and familial evidence of (primarily mucocutaneous) bleeding, and confirmed by laboratory testing. The latter typically entails initial plasma testing of factor VIII coagulant, von Willebrand factor (VWF) protein ('antigen') and VWF function which has classically been assessed using the ristocetin cofactor (VWF:RCo) assay. More recent attention has focussed on other functional VWF assays, such as collagen binding and so-called 'VWF activity' assays, as possible replacements to the VWF:RCo, or as supplementary tests of VWF 'function'. Additional laboratory testing can comprise a battery of confirmatory and VWD-type assisting assays, including VWF:multimer and von Willebrand factor VIII binding. This review aims to update knowledge of current VWD diagnostics with a particular emphasis on 'functional' VWF assays.

  18. Active packaging for fresh-cut broccoli using 1-methylcyclopropene in biodegradable sachet/ Embalagem ativa para brócolis minimamente processado utilizando 1-metilciclopropeno em sachê biodegradável

    Directory of Open Access Journals (Sweden)

    Marta de Toledo Benassi

    2006-07-01

    Full Text Available Fresh-cut broccoli florets were packed in polypropylene pots containing a sachet with 1- methylcyclopropene (1-MCP and sealed with biodegradable starch-based film. Broccoli was stored for 8 days at 12oC and after this time the color and the texture of the product were similar of the fresh broccoli, with no off-flavor development or decay. Active packaging with 1-MCP in a sachet was efficient to extent shelf life of broccoli florets retarding yellowing and vitamin C losses. It is an alternative of 1-MCP treatment for fresh-cut products and besides, the sachet can absorbs condensed water reducing spoilage and off-odor development.Brócolis minimamente processados foram embalados em bandejas de polipropileno com sachê contendo 1-metilciclopropeno (1-MCP e selado com filme biodegradável de amido. Os brócolis foram armazenados por 8 dias a 12oC e após este tempo a cor e a textura mantiveram-se similares às do produto fresco, sem desenvolvimento de odor não característico ou podridão. A embalagem ativa contendo 1-MCP na forma de sachê foi eficiente no aumento da vida de prateleira de brócolis, retardando o amarelecimento e a perda de vitamina C. Esta é uma alternativa para o tratamento com 1-MCP para produtos minimamente processados e além disso, o sachê pode absorver a água condensada, reduzindo a deterioração e o desenvolvimento de odor não característico.

  19. Common HEXB polymorphisms reduce serum HexA and HexB enzymatic activities, potentially masking Tay-Sachs disease carrier identification.

    Science.gov (United States)

    Vallance, Hilary; Morris, Tara J; Coulter-Mackie, Marion; Lim-Steele, Joyce; Kaback, Michael

    2006-02-01

    A DNA-proven Tay-Sachs disease (TSD) carrier and his brother were found to have serum percent Hexosaminidase A (%HexA) enzymatic activities in the non-carrier range, while the leukocyte %HexA profiles clearly identified them as TSD heterozygotes. Both their serum HexA and HexB enzymatic activities were below reference range, suggesting inheritance of mutations in both the HEXA (alpha-subunit) and HEXB (beta-subunit) genes. DNA sequencing revealed that both individuals, carried the common HEXA 1277_1278insTATC mutation, and two common HEXB polymorphisms: [619A>G (+) delTG]. To determine if these HEXB polymorphisms reduce HexA and HexB enzymatic activities, 69 DNA samples from subjects previously screened enzymatically in both serum and leukocytes for TSD carrier status were selected for either high, mid-range or low serum Total Hex (defined as the sum of HexA and HexB) activities and were tested for the HEXB mutations. Further, three additional TSD carriers ascertained by the atypical pattern of normal serum %HexA but carrier leukocyte %HexA, were found to have the [delTG (+) 619A>G] genotype. In addition, the frequency of the [delTG (+) 619A>G] genotype was significantly higher (P G] haplotype in the Ashkenazi Jewish population (approximately 10%), up to 10% of TSD carriers may have normal serum %HexA values with low total Hex. Accordingly, serum %HexA should not be the sole criterion used for carrier status determination. Where total Hex activity is reduced, further testing with leukocyte Hex profiles is indicated.

  20. Two novel exonic point mutations in HEXA identified in a juvenile Tay-Sachs patient: role of alternative splicing and nonsense-mediated mRNA decay.

    Science.gov (United States)

    Levit, A; Nutman, D; Osher, E; Kamhi, E; Navon, R

    2010-06-01

    We have identified three mutations in the beta-hexoseaminidase A (HEXA) gene in a juvenile Tay-Sachs disease (TSD) patient, which exhibited a reduced level of HEXA mRNA. Two mutations are novel, c.814G>A (p.Gly272Arg) and c.1305C>T (p.=), located in exon 8 and in exon 11, respectively. The third mutation, c.1195A>G (p.Asn399Asp) in exon 11, has been previously characterized as a common polymorphism in African-Americans. Hex A activity measured in TSD Glial cells, transfected with HEXA cDNA constructs bearing these mutations, was unaltered from the activity level measured in normal HEXA cDNA. Analysis of RT-PCR products revealed three aberrant transcripts in the patient, one where exon 8 was absent, one where exon 11 was absent and a third lacking both exons 10 and 11. All three novel transcripts contain frameshifts resulting in premature termination codons (PTCs). Transfection of mini-gene constructs carrying the c.814G>A and c.1305C>T mutations proved that the two mutations result in exon skipping. mRNAs that harbor a PTC are detected and degraded by the nonsense-mediated mRNA decay (NMD) pathway to prevent synthesis of abnormal proteins. However, although NMD is functional in the patient's fibroblasts, aberrant transcripts are still present. We suggest that the level of correctly spliced transcripts as well as the efficiency in which NMD degrade the PTC-containing transcripts, apparently plays an important role in the phenotype severity of the unique patient and thus should be considered as a potential target for drug therapy.

  1. Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay–Sachs mouse models

    Directory of Open Access Journals (Sweden)

    Z.K. Timur

    2015-09-01

    Full Text Available Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA−/− mice, depleted of the β-Hexosaminidase A iso-enzyme, remain asymptomatic up to 1 year of age because of a metabolic bypass by neuraminidase(s. These enzymes remove a sialic acid residue converting GM2 to GA2, which is further degraded by the still intact β-Hexosaminidase B iso-enzyme into lactosylceramide. A previously identified ganglioside metabolizing neuraminidase, Neu4, is abundantly expressed in the mouse brain and has activity against gangliosides like GM2 in vitro. Neu4−/− mice showed increased GD1a and decreased GM1 ganglioside in the brain suggesting the importance of the Neu4 in ganglioside catabolism. Mice with targeted disruption of both HexA and Neu4 genes showed accumulating GM2 ganglioside and epileptic seizures with 40% penetrance, indicating that the neuraminidase Neu4 is a modulatory gene, but may not be the only neuraminidase contributing to the metabolic bypass in HexA−/− mice. Therefore, we elucidated the biological role of neuraminidase-1 in ganglioside degradation in mouse. Analysis of HexA−/−Neu1−/− and HexA−/−Neu4−/−Neu1−/− mice models showed significant contribution of neuraminidase-1 on B-series ganglioside degradation in the brain. Therefore, we speculate that other neuraminidase/neuraminidases such as Neu2 and/or Neu3 might be also involved in the ganglioside degradation pathway in HexA−/− mice.

  2. Neuraminidase-1 contributes significantly to the degradation of neuronal B-series gangliosides but not to the bypass of the catabolic block in Tay-Sachs mouse models.

    Science.gov (United States)

    Timur, Z K; Akyildiz Demir, S; Marsching, C; Sandhoff, R; Seyrantepe, V

    2015-09-01

    Tay–Sachs disease is a severe lysosomal storage disorder caused by mutations in the HEXA gene coding for α subunit of lysosomal β-Hexosaminidase A enzyme, which converts GM2 to GM3 ganglioside. HexA(−/−) mice, depleted of the β-Hexosaminidase A iso-enzyme, remain asymptomatic up to 1 year of age because of a metabolic bypass by neuraminidase(s). These enzymes remove a sialic acid residue converting GM2 to GA2, which is further degraded by the still intact β-Hexosaminidase B iso-enzyme into lactosylceramide. A previously identified ganglioside metabolizing neuraminidase, Neu4, is abundantly expressed in the mouse brain and has activity against gangliosides like GM2in vitro. Neu4(−/−) mice showed increased GD1a and decreased GM1 ganglioside in the brain suggesting the importance of the Neu4 in ganglioside catabolism. Mice with targeted disruption of both HexA and Neu4 genes showed accumulating GM2 ganglioside and epileptic seizures with 40% penetrance, indicating that the neuraminidase Neu4 is a modulatory gene, but may not be the only neuraminidase contributing to the metabolic bypass in HexA(−/−) mice. Therefore, we elucidated the biological role of neuraminidase-1 in ganglioside degradation in mouse. Analysis of HexA(−/−) Neu1(−/−) and HexA(−/−) Neu4(−/−) Neu1(−/−) mice models showed significant contribution of neuraminidase-1 on B-series ganglioside degradation in the brain. Therefore, we speculate that other neuraminidase/neuraminidases such as Neu2 and/or Neu3 might be also involved in the ganglioside degradation pathway in HexA(−/−) mice.

  3. El “Liber Pontificalis de Agnello de Rávena”(s. IX), la génesis del valor histórico y de la didáctica de los “monumentos” en la “Literatura artística de Julius von Schlosser.

    OpenAIRE

    Arjones Fernández, A.

    2005-01-01

    La Nueva Historia del Arte, la Escuela de Viena, supone una renovación para la didáctica de la Historia del Arte en la medida en que reconoce "otras" utilidades al patrimonio cultural, entonces denominado "monumento". El Liber Pontificalis de Agnello fue considerado una fuente documental, la Nueva Historia del Arte concedió a este documento la condición de fuente documental para la Historia del Arte. Este trabajo se expuso en el Simposio de los códices medievales a los libros de artista: c...

  4. El “Liber Pontificalis de Agnello de Rávena”(s. IX), la génesis del valor histórico y de la didáctica de los “monumentos” en la “Literatura artística de Julius von Schlosser.

    OpenAIRE

    Arjones Fernández, A.

    2005-01-01

    La Nueva Historia del Arte, la Escuela de Viena, supone una renovación para la didáctica de la Historia del Arte en la medida en que reconoce "otras" utilidades al patrimonio cultural, entonces denominado "monumento". El Liber Pontificalis de Agnello fue considerado una fuente documental, la Nueva Historia del Arte concedió a este documento la condición de fuente documental para la Historia del Arte. Este trabajo se expuso en el Simposio de los códices medievales a los libros de artista: c...

  5. ‘A dialogue about the art of portraiture’ Originally published as ‘Gespräch von der Bildniskunst’, Österreichische Rundschau, Volume 6, 1906, 502—516, and republished: Julius Schlosser, Präludien Vorträge und Aufsätze, Berlin: Bard 1927, 227—247. Translated with an introduction by Karl Johns

    Directory of Open Access Journals (Sweden)

    Julius Schlosser

    2011-12-01

    Full Text Available In an unusually popular and readable dialogue form, Schlosser alludes to the classical education he takes for granted in any reader approaching his favourite ‘thorny’ questions from aesthetics and history. These involve the problems of naturalism, impressionism, portrait likeness, psychology of perception and numerous others being bandied around academic circles at the turn of the century. It is of further interest in directly referring critically to his recently deceased friend (Alois Riegl, and being written just at a moment in his career when Schlosser had been casting around the ideas of Ernst Brücke, Konrad Lange, even Henri Bergson, but had discovered the recent contribution of Benedetto Croce, which would colour his approach with an increasing intensity for the remainder of his life. He became what might be seen as the archetypical art historical theorist, but continues to distinguish himself from his successors by his greater consistency.

  6. Einfluss von Umweltbedingungen und Entwicklungsstadium auf Ertragsparameter und sekundäre Pflanzeninhaltsstoffe von Zitronenmelisse (Melissa officinalis L.

    Directory of Open Access Journals (Sweden)

    Russo, Marco

    2014-09-01

    Full Text Available Um die Qualität von Arznei- und Gewürzpflanzen langfristig sichern zu können, ist eine genauere Kenntnis der sie beeinflussenden Faktoren von Interesse. Am Beispiel der Zitronenmelisse (Melissa officinalis L. wurden in zwei Feldversuchen an unterschiedlichen Standorten die Einflüsse der Faktoren Lichtintensität, Sorte und Erntezeitpunkt auf Ertragsparameter sowie sekundäre Pflanzeninhaltsstoffe untersucht. Es konnten teilweise deutliche Effekte der unterschiedlichen Lichtbedingungen auf die Gesamtphenole und die antioxidative Kapazität beobachtet werden, die zum Teil signifikanten Wechselwirkungen zwischen den Prüffaktoren unterlagen.

  7. Tay-Sachs disease in an Arab family due to c.78G>A HEXA nonsense mutation encoding a p.W26X early truncation enzyme peptide.

    Science.gov (United States)

    Haghighi, Alireza; Masri, Amira; Kornreich, Ruth; Desnick, Robert J

    2011-12-01

    Tay-Sachs disease (TSD), a pan-ethnic, autosomal recessive, neurodegenerative, lysosomal disease, results from deficient β-hexosaminidase A activity due to β-hexosaminidase α-subunit (HEXA) mutations. Prenatal/premarital carrier screening programs in the Ashkenazi Jewish community have markedly reduced disease occurrence. We report the first Jordanian Arab TSD patient diagnosed by deficient β-hexosaminidase A activity. HEXA mutation analysis revealed homozygosity for a nonsense mutation, c.78G>A (p.W26X). Previously reported in Arab patients, this mutation is a candidate for TSD screening in Arab populations. Copyright © 2011 Elsevier Inc. All rights reserved.

  8. Der gespielte Ernst des Lebens: Bestandsaufnahme und Potenziale von Serius Games (for Health

    Directory of Open Access Journals (Sweden)

    Claudia Lampert

    2009-03-01

    Full Text Available Serious Games werden aktuell im Zusammenhang mit den positiven Potenzialen von Computerspielen in verschiedenen Kontexten diskutiert. Im vorliegenden Beitrag werden die Entwicklung und der Forschungsstand des relativ neuen Konzeptes skizziert und gegenüber anderen Lernkonzepten wie Edutainment, Digital Game-Based Learning und E-learning abgegrenzt. Das Spektrum von Serious Games wird am Beispiel von zwei Spielen aus dem Gesundheitsbereich (Re-Mission und Fatworld dargestellt und die Potenziale und Grenzen von Serious Games (for Health erörtert. Da bislang nur wenige empirische Befunde zur Wirkung von Serious Games vorliegen, plädieren die Autoren für eine umfassende Grundlagen- und Wirkungsforschung.

  9. The education of Ehrenfried Walther von Tschirnhaus (1651-1708).

    Science.gov (United States)

    Adler, Jacob

    2015-02-01

    Ehrenfried Walther von Tschirnhaus, mathematician, inventor, and correspondent of Spinoza, is often thought to have studied medicine at Leiden, though documentation of this fact has been lacking. Tschirnhaus' medical education is here documented, along with the nature of his medical practice.

  10. C. J. Ebhardi ja Balthasar von Campenhauseni projektid / Toivo Meikar

    Index Scriptorium Estoniae

    Meikar, Toivo, 1947-

    2005-01-01

    Lisatud: C. J. Ebhardi Eesti- ja Liivimaa metsa- ja jahiseaduse projekt (valmis hiljemalt aastaks 1770), lk. 199-222 ; Härra maanõuniku parun von Campenhauseni ettepanekud kõikide metsade nõuetekohaseks korralduseks (4. juuli 1778), lk. 223-233

  11. Enfermedad de Von Gierke: Reporte de tres casos

    Directory of Open Access Journals (Sweden)

    Echeverri O.

    2001-06-01

    Full Text Available La enfermedad de Von Gierke es un defecto en la glucosa 6 fosfatasa, degrada el glucógeno en el hígado, riñón e intestino. Asociada con hipoglicemia, acidosis láctica e hiperuricemia.

  12. von Braun Examines Bendix Mobility Test Article (MTA)

    Science.gov (United States)

    1965-01-01

    Marshall Space Flight Center (MSFC) director, Wernher von Braun, and a visitor, examine one concept of a possible Lunar Roving Vehicle (LRV) built by the Bendix Corporation. The data provided by the MTA helped in designing the LRV, developed under the direction of MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions.

  13. Rezension: Kafka von David Zane Mairowitz u. Robert Crumb

    Directory of Open Access Journals (Sweden)

    Johanna Lenhart

    2015-12-01

    Full Text Available Die inzwischen schon fast als Klassiker gehandelte Comicadaption von Franz Kafkas Leben und Werk wird zwanzig Jahre nach Erscheinen neu aufgelegt. Johanna Lenhart rezensierte für die MEDIENIMPULSE die visuelle Einführung des Autorenduos Crumb/Mairowitz in Kafkas Welt.

  14. Mollusken aus posttertiären Schichten von Celebes

    NARCIS (Netherlands)

    Schepman, M.M.

    1912-01-01

    Die im Folgenden behandelten Mollusken stammen aus der Nähe von Kajoe ragi auf Celebes, woselbst sie durch R. FENNEMA aus denselben Schichten ausgelesen wurden, aus denen früher durch J. G. DE MAN einige brachyure Krebse beschrieben sind. Es darf deswegen betreffs näherer Angaben über die Herkunft

  15. Lernen von las Cuencas / Aprendiendo de las Cuencas

    DEFF Research Database (Denmark)

    Allen, Nacho Ruiz; López Arraiza, Sara

    2015-01-01

    Lernen von las Cuencas / Aprendiendo de las Cuencas (Learning from las Cuencas) research project, awarded with the EU Prize for Cultural Heritage / Europa Nostra Awards 2015, provides a new perspective of industrial cultural landscapes. Despite being focused on a local environment, the coal minin...

  16. Characterizing ξ-Lie Multiplicative Isomorphisms on Von Neumann Algebras

    Directory of Open Access Journals (Sweden)

    Yamin Song

    2014-01-01

    Full Text Available Let ℳ and be von Neumann algebras without central summands of type I1. Assume that ξ∈ℂ with ξ≠1. In this paper, all maps Φ:ℳ→ satisfying ΦAB-ξBA=ΦAΦB-ξΦBΦ(A are characterized.

  17. Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure

    Science.gov (United States)

    Joldersma, Clarence W.

    2011-01-01

    In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

  18. Bemerkungen zu Alexander von Humboldts Russland-Tagebuch

    Directory of Open Access Journals (Sweden)

    Petra Werner

    2008-04-01

    Full Text Available Article in German, Abstracts in English and GermanIn this study the fragment of Alexander von Humboldt’s Siberian personal diary of 1829 is introduced. The evaluation is focussed on Humboldt’s remarks about mineral resources, especially gold and diamonds. Also mentioned are results which Humboldt recorded about geographical, botanical, meteorological, zoological and ethnological questions.

  19. Professor Oberth and Dr. von Braun at ARS Banquet

    Science.gov (United States)

    1961-01-01

    Dr. Wernher von Braun holds the coveted Hermarn Oberth award presented to him by Professor Oberth during the banquet hosted by the Alabama Section of the American Rocket Society (ARS), on October 19, 1961. The Oberth award was given for outstanding technical contributions to the field of astronautics or for the promotion and advancement of astronautical sciences.

  20. Ernst von Glasersfeld's Radical Constructivism and Truth as Disclosure

    Science.gov (United States)

    Joldersma, Clarence W.

    2011-01-01

    In this essay Clarence Joldersma explores radical constructivism through the work of its most well-known advocate, Ernst von Glasersfeld, who combines a sophisticated philosophical discussion of knowledge and truth with educational practices. Joldersma uses Joseph Rouse's work in philosophy of science to criticize the antirealism inherent in…

  1. Krahv Alexander von Keyserling / Sirje Kivimäe

    Index Scriptorium Estoniae

    Kivimäe, Sirje, 1947-

    2002-01-01

    Alexander Friedrich Michael Lebrecht Arthur Nicolaus James von Keyserlingi (1815-1891) elust ja teaduslikest ekspeditsioonidest Venemaal ning tegevusest Eestis Raikküla mõisnikuna, loodusteadlasena, Eestimaa rüütelkonna peamehena, eesti talupoegade olukorra parandajana, Tartu õpperingkonna kuraatorina, maanõunikuna, tema pereelust ja lastest

  2. Mollusken aus posttertiären Schichten von Celebes

    NARCIS (Netherlands)

    Schepman, M.M.

    1912-01-01

    Die im Folgenden behandelten Mollusken stammen aus der Nähe von Kajoe ragi auf Celebes, woselbst sie durch R. FENNEMA aus denselben Schichten ausgelesen wurden, aus denen früher durch J. G. DE MAN einige brachyure Krebse beschrieben sind. Es darf deswegen betreffs näherer Angaben über die Herkunft d

  3. Sakslased tulevad! Ärevad ajad Tallinnas Von Krahli Teatris

    Index Scriptorium Estoniae

    2001-01-01

    Von Krahli Teater ja Showcase Beat Le Mot valmistuvad oma esimeseks koostööprojektiks - lavastuseks "Pirates", kus osalevad mõlema teatri näitlejad ja tehnikud. Ühisprojekti toetavad Goethe Instituut, Hamburgi Linnavalitsus ja Eesti Kultuurkapital

  4. Manuelle Montage von Großgeräten

    Science.gov (United States)

    Lotter, Bruno

    Die manuelle Montage von Großgeräten — wie. z. B. Maschinen, Traktoren, Haushaltsgeräte, PKW-Motoren, LKW-Achsen, Schaltschränke usw. — wird in ihrer Montagestruktur vorrangig durch das Produktgewicht, die Produktabmessung und die Produktionsrate bestimmt.

  5. Linckia rosenbergi Von Martens, a Synonym of L. laevigata (L.)

    NARCIS (Netherlands)

    Engel, H.

    1942-01-01

    When Clark (1921) cleared the genus Linckia from superfluous synonyms, he could give no opinion on Linckia rosenbergi Von Martens 1866, p. 63 from Amboina. The unique holotype was in the Berlin Museum and hence not easily accessible to him, the species had not been described again. In his key Clark

  6. Alexander von Humboldt als astronomischer Arbeiter, Diskussionspartner und Ideengeber

    Directory of Open Access Journals (Sweden)

    Oliver Schwarz

    2014-12-01

    Full Text Available Auf welche Weise sich unsere Einschätzung des wissenschaftlichen Wirkens Alexander von Humboldts auf Grundlage der beständig voranschreitenden Erschließung seiner Handschriften verändern konnte und welche aktuellen wissenschaftshistorischen Fragestellungen dadurch aufgeworfen wurden, verdeutlicht Oliver Schwarz an Beispielen aus der Astronomie.

  7. KK -theory and spectral flow in von Neumann algebras

    DEFF Research Database (Denmark)

    Kaad, Jens; Nest, Ryszard; Rennie, Adam

    2012-01-01

    We present a definition of spectral flow for any norm closed ideal J in any von Neumann algebra N. Given a path of selfadjoint operators in N which are invertible in N/J, the spectral flow produces a class in Ko (J). Given a semifinite spectral triple (A, H, D) relative to (N, t) with A separable...

  8. Von Kármán between Aachen and Pasadena

    Science.gov (United States)

    Krause, Egon; Kalkmann, Ulrich

    2013-05-01

    In the Introduction the reader is referred back to the academic ceremonials held after Theodore von Kármán's death in Aachen in May 1963. His work as the first director of the Aerodynamisches Institut (Institute of Aerodynamics) of the RWTH Aachen University of Technology from 1913 on and his initiative to re-establish international cooperation after World War I, resulting in the International Union of Theoretical and Applied Mechanics (IUTAM), are commented on. The following chapter describes von Kármán's relation to his former teacher Ludwig Prandtl. Some of von Kármán's scientific contributions during his time in Aachen are briefly reviewed. Thereafter, his first contacts to the California Institute of Technology are covered. Finally, the scientific and political circumstances, which led to von Kármán's decision to leave Germany in the early thirties, are elucidated in some detail. The English translation of the titles of the Aachen papers is given in Appendix I.

  9. On prime non-primitive von Neumann regular algebras

    CERN Document Server

    Abrams, Gene; Rangaswamy, Kulumani M

    2011-01-01

    Let $E$ be any directed graph, and $K$ any field. We classify those graphs $E$ for which the Leavitt path algebra $L_K(E)$ is primitive. As a consequence, we obtain classes of examples of von Neumann regular prime rings which are not primitive.

  10. Von Willebrand factor deficiency reduces liver fibrosis in mice

    NARCIS (Netherlands)

    Joshi, Nikita; Kopec, Anna K.; Ray, Jessica L.; Cline-Fedewa, Holly; Groeneveld, Dafna J.; Lisman, Ton; Luyendyk, James P.

    2017-01-01

    Liver diseases are associated with complex changes in the hemostatic system and elevated levels of the platelet adhesive protein Von Willebrand factor (VWF) are reported in patients with acute and chronic liver damage. Although elevated levels of VWF are associated with fibrosis in the general popul

  11. C. J. Ebhardi ja Balthasar von Campenhauseni projektid / Toivo Meikar

    Index Scriptorium Estoniae

    Meikar, Toivo, 1947-

    2005-01-01

    Lisatud: C. J. Ebhardi Eesti- ja Liivimaa metsa- ja jahiseaduse projekt (valmis hiljemalt aastaks 1770), lk. 199-222 ; Härra maanõuniku parun von Campenhauseni ettepanekud kõikide metsade nõuetekohaseks korralduseks (4. juuli 1778), lk. 223-233

  12. Active von Willebrand factor in thrombotic thrombocytopenic purpura and malaria

    NARCIS (Netherlands)

    Groot, E.

    2009-01-01

    Thrombotic thrombocytopenic purpura (TTP) and malaria are two diseases of distinct origin. TTP is a rare disorder caused by a deficiency of the von Willebrand factor (VWF) cleaving protease ADAMTS13. Malaria is a poverty-related disease caused by protozoan parasites from the genus Plasmodium. TTP an

  13. von Hippel-Lindau development in children and adolescents

    DEFF Research Database (Denmark)

    Launbjerg, Karoline; Bache, Iben; Galanakis, Michael

    2017-01-01

    The autosomal dominant von Hippel-Lindau disease (vHL) is associated with a lifelong risk of tumor development, especially retinal and CNS hemangioblastomas, pheochromocytoma, and renal cell carcinoma. Knowledge of paediatric vHL development is limited, and current surveillance guidelines are based...

  14. Gorgonaria von Konakry, Liberia, Goldküste und Angola

    NARCIS (Netherlands)

    Stiasny, G.

    1937-01-01

    Ich berichte hier über die Ergebnisse der Untersuchung einiger westafrikanischer Gorgonaria aus dem Äquatorialgebiet. In den Sammlungen des Rijksmuseum van Natuurlijke Historie, Leiden, befinden sich zahlreichie Exemplare von Liberia, der Goldküste und Angola. Angeschlossen wird eine kurze Beschreib

  15. Subklinische Hyperthyreose - eine vernachlässigte Ursache von Vorhofflimmern

    Directory of Open Access Journals (Sweden)

    Scheibner P

    2001-01-01

    Full Text Available Die manifeste Hyperthyreose ist eine der häufigsten und wichtigsten extrakardialen Ursachen für Vorhofflimmern, wobei die Inzidenz von Vorhofflimmern bei manifester Hyperthyreose etwa 15-20 % erreicht. Demgegenüber ist eine klare Assoziation zwischen latenter Hyperthyreose und Vorhofflimmern weniger etabliert. Allgemein akzeptierte Richtlinien für eine Therapie der latenten Hyperthyreose, vor allem im Hinblick auf ihre mögliche arrhythmogene Potenz, liegen gegenwärtig nicht vor. Unsere Daten zeigen klar, daß die Prävalenz von Vorhofflimmern durch das Vorliegen einer subklinischen Hyperthyreose in ähnlichem Ausmaß erhöht wird wie durch manifeste Hyperthyreose. Es ist daher zu fordern, daß auch nach einer latenten Hyperthyreose als Ursache von Vorhofflimmern gefahndet wird. Beim Nachweis einer subklinischen Schilddrüsenüberfunktion sollte diese, insbesondere bei älteren Patienten, konsequent therapiert werden, um das hyperthyreoseinduzierte Auftreten von Vorhofflimmern und seiner Komplikationen zu vermeiden.

  16. Treasure in the Library Attic: Von Ranke at Syracuse.

    Science.gov (United States)

    Coville, Bruce

    1984-01-01

    Traces history of private library of German scholar, Leopold von Ranke, which was purchased by Syracuse University in 1888. Efforts of librarian Charles W. Bennett in 1870s and Professor James Powell beginning in late 1960s, and restoration and cataloging of collection are highlighted. Items from the collection are noted. (EJS)

  17. Lars von Triers fornyelse af filmen 1984-2014

    DEFF Research Database (Denmark)

    Thomsen, Bodil Marie Stavning

    Bogen undersøger Lars von Triers affektskabende og etisk involverende stil med udgangspunkt i hans værker over en 30-årig periode (1984-2014). Centralt i bogens læsninger står væsentlige analytiske begreber som det haptiske, det affektive, det diagrammatiske og det signaletiske materiale, der med...

  18. von Braun Examines Bendix Mobility Test Article (MTA)

    Science.gov (United States)

    1965-01-01

    Marshall Space Flight Center (MSFC) director, Wernher von Braun, and a visitor, examine one concept of a possible Lunar Roving Vehicle (LRV) built by the Bendix Corporation. The data provided by the MTA helped in designing the LRV, developed under the direction of MSFC. The LRV was designed to allow Apollo astronauts a greater range of mobility during lunar exploration missions.

  19. Von Hippel-Lindau disease (vHL)

    DEFF Research Database (Denmark)

    Binderup, Marie Louise Mølgaard; Bisgaard, Søs Marie Luise; Harbud, Vibeke

    2013-01-01

    These clinical guidelines outline the criteria and recommendations for diagnostic and genetic work-up of families suspected of von Hippel-Lindau disease (vHL), as well as recommendations for prophylactic surveillance for vHL patients. The guideline has been composed by the Danish Coordination Gro...

  20. Wernher von Braun: Reflections on His Contributions to Space Exploration

    Science.gov (United States)

    Goldman, Arthur E.

    2012-01-01

    In 1950, Dr. Wernher von Braun and approximately 100 of his team members came to Huntsville, Alabama, to begin work with the Army on what would later become America's historic space program. He would later serve as the first director of the Marshall Space Flight Center and led the development of the Saturn V launch vehicle that launched seven crewed American mission to the moon, as well as America s first space station, Skylab. Von Braun is best known for his team s technical achievements. He realized his dream of exploring outer space by helping place humans on the moon. His engineering and managerial talent during the Apollo era had contributed to a technological revolution. He was by all accounts a good engineer, but he was only one among many. What set Von Braun apart were his charisma, his vision, and his leadership skills. He inspired loyalty and dedication in the people around him. He understood the importance of communicating his vision to his team, to political and business leaders and the public. Today, the Marshall Center continues his vision by pursuing engineering and scientific projects that will continue to open space to exploration. This presentation will discuss Von Braun's impact on Huntsville, the Marshall Center, the nation and the world and look at his contributions in context of where world space exploration is today.