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Sample records for izumi tsutomu nakamura

  1. Regional new energy vision for Izumi City; 2001 nendo Izumi shi chiiki shin energy vision

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-02-01

    For promoting the introduction of new energy and for elevating people's consciousness of such in Izumi City, Kagoshima Prefecture, surveys and studies were conducted concerning the energy demand of the city, the amount of new energy resources in existence, and new energy introduction plans, and then a vision was formulated. The city's yearly energy demand is estimated at approximately 4,011,009 GJ, with approximately 61% to be met by oil-based fuels and approximately 31% by electric power. The amount of new energy resources in existence is estimated at 1,633,806 GJ, equivalent to approximately 41% of the amount of demanded energy. Projects for new energy introduction were discussed, which included the introduction of photovoltaic power into Crane Park, Izumi Municipal Lyceum, and city-operated primary and junior high schools; introduction of a wind power system (600 kW) into the Uwaba highland district; installation of hybrid power-lighted outdoor light in the vicinity of Izumi railway station, in parks, and along a jogging road; introduction of a cogeneration system utilizing biomass energy from a sewage treatment plant; use of hybrid cars for official service; promotion of the introduction of photovoltaic power systems into residences; and electric appliance improvement for power conservation. (NEDO)

  2. Nobel Prize 2014: Akasaki, Amano & Nakamura

    Science.gov (United States)

    Heber, Joerg

    2014-11-01

    The 2014 Nobel Prize in Physics has been awarded to Isamu Akasaki, Hiroshi Amano and Shuji Nakamura "for the invention of efficient blue light-emitting diodes which has enabled bright and energy-saving white light sources."

  3. The exoticness and realisability of twisted Haagerup-Izumi modular data

    CERN Document Server

    Evans, David E

    2010-01-01

    The quantum double of the Haagerup subfactor, the first irreducible finite depth subfactor with index above 4, is the most obvious candidate for exotic modular data. We show that its modular data DHg fits into a family $D^\\omega Hg_{2n+1}$, where $n\\ge 0$ and $\\omega\\in \\bbZ_{2n+1}$. We show $D^0 Hg_{2n+1}$ is related to the subfactors Izumi hypothetically associates to the cyclic groups $Z_{2n+1}$. Their modular data comes equipped with canonical and dual canonical modular invariants; we compute the corresponding alpha-inductions etc. In addition, we show there are (respectively) 1, 2, 0 subfactors of Izumi type $Z_7$, $Z_9$ and $Z_3^2$, and find numerical evidence for 2, 1, 1, 1, 2 subfactors of Izumi type $Z_{11},Z_{13},Z_{15},Z_{17},Z_{19}$ (previously, Izumi had shown uniqueness for $Z_3$ and $Z_5$), and we identify their modular data. We explain how DHg (more generally $D^\\omega Hg_{2n+1}$) is a graft of the quantum double DSym(3) (resp. the twisted double $D^\\omega D_{2n+1}$) by affine so(13) (resp. so...

  4. Fandom unbound: Otaku culture in a connected world, edited by Mizuko Ito, Daisuke Okabe, and Izumi Tsuji [book review

    Directory of Open Access Journals (Sweden)

    Nele Noppe

    2015-03-01

    Full Text Available Review of Mizuko Ito, Daisuke Okabe and Izumi Tsuji, eds. Fandom unbound: Otaku culture in a connected world. New Haven, CT: Yale University Press, 2012, Kindle edition, $35; paperback, $38 (352p ISBN 978-0300158649.

  5. Nakamura Ryûtarô’s Anime, Serial Experiments, Lain (1998

    Directory of Open Access Journals (Sweden)

    Tamae KOBAYASHI PRINDLE

    2015-07-01

    Full Text Available This paper introduces Nakamura Ryūtarō’s anime, Serial Experiments, Lain (1998 as a new type of anime, a genre nameable as an “expository anime”, for the reason that it creates a diachronic story out of a synchronic aspect of a certain field of science. The overarching topic of Experiments is electronics, focusing on the comparison between digital and analogue communication systems. Experiments unfolds the rationales, potentials, and effects of the two types of communication systems using the perceptions of the major character, a thirteen-year old girl, Rein, as well as other supporting characters.

  6. Improved fast-rotating black hole evolution simulations with modified Baumgarte-Shapiro-Shibata-Nakamura formulation

    CERN Document Server

    Yo, Hwei-Jang; Lin, Chun-Yu; Pan, Hsing-Po

    2015-01-01

    Different formulations of Einstein's equations used in numerical relativity can affect not only the stability but also the accuracy of numerical simulations. In the original Baumgarte-Shapiro-Shibata-Nakamura (BSSN) formulation, the loss of the angular momentum, $J$, is non-negligible in highly spinning single black hole evolutions. This loss also appears, usually right after the merger, in highly spinning binary black hole simulations, The loss of $J$ may be attributed to some unclear numerical dissipation. Reducing unphysical dissipation is expected to result in more stable and accurate evolutions. In the previous work \\cite{yhlc12} we proposed several modifications which are able to prevent black hole evolutions from the unphysical dissipation, and the resulting simulations are more stable than in the traditional BSSN formulation. Specifically, these three modifications (M1, M2, and M3) enhance the effects of stability, hyperbolicity, and dissipation of the formulation. We experiment further in this work w...

  7. Quasinormal modes in the extreme Kerr limit and asymptotic behavior of the Sasaki-Nakamura transformation

    CERN Document Server

    Nakano, Hiroyuki; Tanaka, Takahiro; Nakamura, Takashi

    2016-01-01

    The Sasaki-Nakamura transformation gives a short-ranged potential and a convergent source term for the master equation of perturbations in the Kerr space-time. In this paper, we study the asymptotic behavior of the transformation, and present a new relaxed necessary and sufficient condition of the transformation to obtain the short-ranged potential in the assumption that the transformation converges in the far distance. Also, we discuss quasinormal mode frequencies which are determined by the information around the peak of the potential in the WKB analysis. Finally, in the extreme Kerr limit, $a/M \\to 1$, where $M$ and $a$ denote the mass and spin parameter of a Kerr black hole, respectively, we find the peak location of the potential, $r_p/M \\lesssim 1 + 1.8 \\,(1-a/M)^{1/2}$ by using the new transformation. The uncertainty of the location is as large as that expected from the equivalence principle.

  8. Dawsonite and other carbonate veins in the Cretaceous Izumi Group, SW Japan: a natural support for fracture self-sealing in mud-stone cap-rock in CGS?

    Energy Technology Data Exchange (ETDEWEB)

    Okuyama, Yasuko; Funatsu, Takahiro; Fujii, Takashi [Institute for Geo-Resources and environment, GSJ, AISI, 1-1-1 Higashi, Central 7, Tsukuba, ibaraki 305-8567 (Japan); Take, Shuji [Kishiwada Nature Club, c/o Kishiwada City Natural History Museum, Sakai-Machi 5-6, Kishiwada, Osaka 596-0072 (Japan)

    2013-07-01

    Dawsonite-bearing carbonate veins are abundant in a compact mud-stone layer of the lower part of the Izumi Group, SW Japan. The mode of occurrence of the veins probably indicates fracturing and mineral sealing associated with upwelling of CO{sub 2}-rich fluid evolved in the reservoir beneath. The carbonate veins studied here can be a natural support to fracturing and healing of mud-stone cap-rock in the CO{sub 2} geological storage. (authors)

  9. Change of Narrative Point of View in the Novels of Kyoka Izumi%泉镜花小说叙事视角的更迭

    Institute of Scientific and Technical Information of China (English)

    宿久高; 孙艳华

    2012-01-01

    The novels of Kyoka Izumi play an important role in novels. During his 47 years of writing career, his narrative point another: initially the omniscient point of view, soon first-person the history of Japanese romantic of view changes from one work to narrative point of view, then omniscient point of view, and again and finally third-person point of view. The first-person narrative point of view in Kyoka' s novels has rich "connotation", while his third-person limited narrative point of view "subverts" the narrative rules of modern fiction. The hidden reasons of the change for narrative point of view are the influence of Japanese literature, the change of his writing style and his aesthetic tropism.%泉镜花的小说在日本浪漫主义小说史上占有极其重要的地位。在泉镜花长达47年的文学创作中,其小说的叙事视角经历了较大的变化过程。泉镜花的小说从上帝式的全知叙事视角起步,不久即与之背离,以第一人称叙事视角取而代之。之后,他曾一度向全知叙事视角回归,但最终还是第三人称限制叙事视角“异军突起”,势拔头筹。泉镜花小说的第一人称叙事视角“内涵”丰富,第三人称限制叙事视角“颠覆”了现代小说的叙事规则。决定其叙事人称更迭的潜因是日本文学大潮的影响、作品风格以及泉镜花自身审美取向的转变。

  10. Relative seismic shaking vulnerability microzonation using an adaptation of the Nakamura Horizontal to Vertical Spectral Ratio Method

    Indian Academy of Sciences (India)

    Michael L Turnbull

    2008-11-01

    An alternative seismic shaking vulnerability survey method to computational intensive theoretical modelling of site response to earthquake, and time consuming test versus reference site horizontal ratio methods, is described. The methodology is suitable for small to large scale engineering investigations. Relative seismic shaking vulnerability microzonation using an adaptation of the Nakamura horizontal to vertical spectral ratio method provides many advantages over alternative methods including: low cost; rapid field phase (100 km2 can easily be covered by a single operator in 5 days); low and flexible instrumentation requirements (a single seismometer and data logger of almost any type is required); field data can be collected at any time during the day or night (the results are insensitive to ambient social noise); no basement rock reference site is required (thus eliminating trigger synchronisation between reference and multiple test site seismographs); rapid software aided analysis; insensitivity to ground-shaking resonance peaks; ability to compare results obtained from non-contiguous survey fields. The methodology is described in detail, and a practical case study is provided, including mapped results. The resulting microzonation maps indicate the relative seismic shaking vulnerability for built structures of different height categories within adjacent zones, with a resolution of approximately 1 km.

  11. Comment on Effects of transverse magnetic field on mixed convection in wall plume of power-law fluids, by Gorla, Lee, Nakamura and Pop, IJES, 1993

    CERN Document Server

    Pantokratoras, Asterios

    2007-01-01

    Comment on Effects of transverse magnetic field on mixed convection in wall plume of power-law fluids, by Rama Subba Reddy Gorla, Jin Kook Lee, Shoichiro Nakamura and Ioan Pop [International Journal of Engineering Science, 31 (1993) 1035-1045]. In the above paper the authors treat the boundary layer mixed convection flow of a power-law fluid along a vertical adiabatic surface in a transverse magnetic field with a steady thermal source at the leading edge. The governing non-similar equations are solved by means of a novel finite difference scheme. However, there are two fundamental errors in this paper and the presented results do not have any practical value.

  12. Caracterización dinámica preliminar de suelos de San Juan de Pasto mediante el método de microtrepidaciones propuesto por Nakamura

    Directory of Open Access Journals (Sweden)

    Hugo Edmundo Coral Moncayo, Andrés Geovanny Hillón Sarmiento, Edith Lorena Narváez Mera

    2011-05-01

    Full Text Available Teniendo  en  cuenta  la  amenaza  sísmica  a  la  que  seencuentra sometida la ciudad de San Juan de Pasto, es devital importancia conocer la respuesta o comportamientode  sus  suelos  frente  a  las  ondas  sísmicas. Para  ello  serealizaron estudios de análisis dinámico de  suelos, quepermitieron obtener la caracterización dinámica de 23 sitiosde  la ciudad. El cálculo de periodos de  resonancia se  realizómediante métodos numéricos (Zeevaert, NSR-98, ademásdel  método  de  microtrepidaciones  propuesto  porNakamura. Mediante el programa ProShake se obtuvieronperiodos de resonancia para los 23 sitios, además de losespectros  elásticos  de  respuesta.  Finalmente,  con  losresultados obtenidos se realizó un diagnóstico preliminaren lo referente al uso de la NSR-98, calculando espectroselásticos de diseño mediante la formulación de la NSR-98, y espectros de diseño en función de las condicioneslocales y de los diferentes niveles de intensidad sísmica;espectros que se muestran en una gráfica comparativa.

  13. Constraint-Preserving Boundary Conditions for the Linearized Baumgarte-Shapiro-Shibata-Nakamura Formulation

    Directory of Open Access Journals (Sweden)

    Alexander M. Alekseenko

    2008-01-01

    the existence of the solution is proved using the properties of the reduced system. A treatment is proposed for the full nonlinear BSSN system to construct constraint-preserving boundary conditions without invoking the second order in time reduction. Energy estimates on the principal part of the BSSN system (which is first order in temporal and second order in spatial derivatives are obtained. Generalizations to the case of nonhomogeneous boundary data are proposed.

  14. Caracterización dinámica preliminar de suelos de San Juan de Pasto mediante el método de microtrepidaciones propuesto por Nakamura

    National Research Council Canada - National Science Library

    Hugo Edmundo Coral Moncayo, Andrés Geovanny Hillón Sarmiento, Edith Lorena Narváez Mera

    2011-01-01

    Teniendo en cuenta la amenaza sísmica a la que se encuentra sometida la ciudad de San Juan de Pasto, es de vital importancia conocer la respuesta o comportamiento de sus suelos frente a las ondas sísmicas...

  15. MICROZONIFICACIÓN SÍSMICA DE LA CIUDAD DE LÁZARO CÁRDENAS MICHOACÁN UTILIZANDO EL MÉTODO DE NAKAMURA

    OpenAIRE

    García Rangel, Gerardo

    2012-01-01

    La ciudad de Lázaro Cárdenas (LC) se encuentra en el sector meridional de la costa del estado de Michoacán, dentro de una de las zonas más sísmicas del país en la que se han originado los sismos de mayor magnitud en la historia de México, como el sismo de 1985 que causó graves daños en la ciudad de México. Entre los años de 1980 a 2000, y en respuesta a un progreso comercial e industrial de la Siderúrgica y Puerto Internacional, esta ciudad presentó crecimientos de 275% y de 33...

  16. Comparative study of bioactivity of collagen scaffolds coated with graphene oxide and reduced graphene oxide

    Directory of Open Access Journals (Sweden)

    Kanayama I

    2014-07-01

    Full Text Available Izumi Kanayama,1 Hirofumi Miyaji,1 Hiroko Takita,2 Erika Nishida,1 Maiko Tsuji,3 Bunshi Fugetsu,4,5 Ling Sun,4,5 Kana Inoue,1 Asako Ibara,1 Tsukasa Akasaka,6 Tsutomu Sugaya,1 Masamitsu Kawanami1 1Department of Periodontology and Endodontology, 2Support Section for Education and Research, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan; 3Mitsubishi Gas Chemical Company, Inc., Tokyo, Japan; 4Division of Frontier Research, Research Department, Creative Research Institution Sousei, 5Graduate School of Environmental Science, 6Department of Biomedical, Dental Materials and Engineering, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Japan Background: Graphene oxide (GO is a single layer carbon sheet with a thickness of less than 1 nm. GO has good dispersibility due to surface modifications with numerous functional groups. Reduced graphene oxide (RGO is produced via the reduction of GO, and has lower dispersibility. We examined the bioactivity of GO and RGO films, and collagen scaffolds coated with GO and RGO. Methods: GO and RGO films were fabricated on a culture dish. Some GO films were chemically reduced using either ascorbic acid or sodium hydrosulfite solution, resulting in preparation of RGO films. The biological properties of each film were evaluated by scanning electron microscopy (SEM, atomic force microscopy, calcium adsorption tests, and MC3T3-E1 cell seeding. Subsequently, GO- and RGO-coated collagen scaffolds were prepared and characterized by SEM and compression tests. Each scaffold was implanted into subcutaneous tissue on the backs of rats. Measurements of DNA content and cell ingrowth areas of implanted scaffolds were performed 10 days post-surgery.Results: The results show that GO and RGO possess different biological properties. Calcium adsorption and alkaline phosphatase activity were strongly enhanced by RGO, suggesting that RGO is effective for osteogenic differentiation. SEM showed that

  17. Main: 1WIV [RPSD[Archive

    Lifescience Database Archive (English)

    Full Text Available da, S.Yokoyama Y.Higuchi, T.Abe, H.Hirota, K.Izumi, M.Yoshida...gment: Uba Domain; Synonym: Ubp14; Engineered: Yes Structural Genomics, Unknown Function Y.Higuchi, T.Abe, H.Hirota, K.Izumi, M.Yoshi

  18. The Effects of Output Task Types on Noticing and Learning of the English Past Counterfactual Conditional

    Science.gov (United States)

    Song, Mi-Jeong; Suh, Bo-Ram

    2008-01-01

    Drawing on the psycholinguistic rationale and empirical research on output (e.g., [Izumi, S., 2002. "Output, input enhancement, and the noticing hypothesis: An experimental study on ESL relativization." "Studies in Second Language Acquisition" 24, 541-577; Izumi, S., Bigelow, M., 2000. "Does output promote noticing and second language…

  19. Preparations of Proceedings Manuscript for NATO-ARW-DIMRP 88 Direct and Inverse Methods in Radar Polarimetry, Bad Windsheim, FRG, 18-24 September 1988

    Science.gov (United States)

    1991-08-30

    is discussed. The next three papers deal with po- larimetric sensing and imaging of "volumetric scattering scenarios" such as on underground radar imaging...SURFACE Hans Hellsten 1137 V-8 POLARIMETRIC SIGNAL PROCESSING IN UNDERGROUND RADAR Tsutomu Suzuki, Ikuo Arai and Tetsuo Hara 1143 V-9... UNDERGROUND RADAR Tsutomu Suzuki, Ikuo Arai and Tetsuo Hara 1143 V-9 THEORETICAL MODELS FOR POLARIMETRIC MICROWAVE REMOTE SENSING OF EARTH TERRAIN

  20. Association of medications for lifestyle-related diseases with reflux esophagitis

    Directory of Open Access Journals (Sweden)

    Asaoka D

    2016-10-01

    Full Text Available Daisuke Asaoka,1 Akihito Nagahara,2 Mariko Hojo,1 Kenshi Matsumoto,1 Hiroya Ueyama,1 Kohei Matsumoto,1 Kentaro Izumi,1 Tsutomu Takeda,1 Hiroyuki Komori,1 Yoichi Akazawa,1 Yuji Shimada,2 Taro Osada,1 Sumio Watanabe1 1Department of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, 2Department of Gastroenterology, Juntendo University Shizuoka Hospital, Shizuoka, Japan Background: Because of a change in lifestyle, especially adoption of westernized eating habits, lifestyle-related diseases have become increasingly prevalent. The aim of this study was to investigate the association of medications for lifestyle-related diseases with reflux esophagitis (RE.Methods: We conducted a hospital-based, cross-sectional retrospective study of consecutive outpatients who received an upper gastrointestinal endoscopy in our department from February 2008 to November 2014, which was performed by one specialist who was a member of the Japan Gastroenterological Endoscopy Society. We investigated the patient profile, Helicobacter pylori (H. pylori infection status, medications for lifestyle-related diseases (including calcium channel blockers, statins, and bisphosphonates, and upper gastrointestinal endoscopic findings (RE, hiatal hernia, Barrett’s mucosa, and endoscopic gastric mucosal atrophy [EGA]. Patients with gastrectomy, peptic ulcer disease, gastric or esophageal malignant disease, and those who used proton pump inhibitors or histamine-2 receptor antagonists were excluded. We divided the subjects into a group without RE (RE(– and a RE (RE(+ group as judged by endoscopy, and investigated the risk factors for RE.Results: Of 1,744 consecutive cases, 590 cases (300 males and 290 females; mean age 60.5±13.2 years were eligible. RE(– and RE(+ cases numbered 507 and 83, respectively. Bivariate analysis showed significant positive associations of RE with male sex, body mass index (BMI, calcium channel blockers, Barrett’s mucosa, hiatal

  1. Kunst vallutab kaubamaja, Tokyo Londoni / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2001-01-01

    Mais Londoni Selfridgesi kaubamajas pakutavast jaapanielamusest. Jaapani kunstnike Masato Nakamura, Nobumichi Tosa, Kiji Mizutani, Hiroyuki Matsukage, Tatsumi Orimoto ja rühmituse Command N esinemisest.

  2. Sample Set (SE): SE34 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available examined. Yukiko Nakamura, Takeshi Ara, Takashi Matsuura, Mitsuo Enomoto, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Kazusa DNA Research Institute Direct Submittion version 1 ...

  3. Kunst vallutab kaubamaja, Tokyo Londoni / Maria-Kristiina Soomre

    Index Scriptorium Estoniae

    Soomre, Maria-Kristiina, 1978-

    2001-01-01

    Mais Londoni Selfridgesi kaubamajas pakutavast jaapanielamusest. Jaapani kunstnike Masato Nakamura, Nobumichi Tosa, Kiji Mizutani, Hiroyuki Matsukage, Tatsumi Orimoto ja rühmituse Command N esinemisest.

  4. Disease: H00058 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available 4:581-91 (2001) PMID:20428114 (ALS12) Maruyama H, Morino H, Ito H, Izumi Y, Kato H, Watanabe Y, Kinoshita Y,...K, Suzuki N, Aoki M, Kawata A, Hirai T, Kato T, Ogasawara K, Hirano A, Takumi T, Kusaka H, Hagiwara K, Kaji

  5. 手外科杂志(美国卷)近期部分文章摘要译文

    Institute of Scientific and Technical Information of China (English)

    马世伟

    2003-01-01

    @@ 1.由屈肌腱滑膜脂肪瘤引发板机腕及腕管综合征1例报告 本文译自(美国卷)2002年第27卷第6期,作者:Hironori Sonoda,Mitsuhiro Takasita,Hirofu-mi Taira, Tsutomu Higashi and Hiroshi Tsumura.文题:Carpal tunnel syndrome and trigger wrist caused bya lipoma arising from flexor tenosynovium a casereport

  6. Baltemi kauaoodatud müügikeskus avas uksed / Eva Kiisler

    Index Scriptorium Estoniae

    Kiisler, Eva

    2007-01-01

    Jaapani kapitalil põhinev AS Balti Ehitusmasin-Baltem avas 22. mail 2007. a. Tallinna külje all Peetri külas ehitusmasinate müügikeskuse, investeerides selle rajamisse ligi 50 miljonit krooni. Vt. samas: Tsutomu Sakurai: Komatsu on käivet kasvatanud tänu uusriikidele. Jaapani ettevõtte Komatsu Europe president räägib Komatsu ja Sumitomo plaanidest Eesti turul

  7. A Preliminary Study of the Osteogenic Potential of a Biodegradable Alloplastic-Osteoinductive Alloimplant

    Science.gov (United States)

    1987-06-01

    Glowacki, J., and Mulliken, J. B.: Demineralized bone implants. Clin. Plast. Surg. 12:233, 1985. 12. Higashi, S., Yamamuro , T., Nakamura, T., Ikada... Yamamuro , T., Nakamura, T. , Ikada, Y., Hyon, p S. H., and Jamshidi, K.: Polymer-hydroxyapatite composites for biodegradable bone fillers

  8. Database Description - JSNP | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available : Hirakawa M, Tanaka T, Hashimoto Y, Kuroda M, Takagi T, Nakamura Y. Journal: Nucleic Acids Research, 30:158...or name(s): Haga H, Yamada R, Ohnishi Y, Nakamura Y, Tanaka T. Journal: Journal of Human Genetics, 2002;47(1

  9. Non-unitary fusion categories and their doubles via endomorphisms

    CERN Document Server

    Evans, David E

    2015-01-01

    We realise non-unitary fusion categories using subfactor-like methods, and compute their quantum doubles and modular data. For concreteness we focus on generalising the Haagerup-Izumi family of Q-systems. For example, we construct endomorphism realisations of the (non-unitary) Yang-Lee model, and non-unitary analogues of one of the even subsystems of the Haagerup subfactor and of the Grossman-Snyder system. We supplement Izumi's equations for identifying the half-braidings, which were incomplete even in his Q-system setting. We conjecture a remarkably simple form for the modular S and T matrices of the doubles of these fusion categories. We would expect all of these doubles to be realised as the category of modules of a rational VOA and conformal net of factors. We expect our approach will also suffice to realise the non-semisimple tensor categories arising in logarithmic conformal field theories.

  10. Biomolecular Mechanism, Cloning, Sequencing and Analysis of Adaptive Reflection cDNAs and Proteins from Squid

    Science.gov (United States)

    2010-05-03

    Mechanism, Adaptive Reflectance, Adaptive Optics, Reflectin, Bragg Reflectors, cDNA, Protien, Squid, Cephalopod, Octopus Daniel E. Morse University of...Tunable Biophotonics: Camouflage and Communication in Squid Inspire New Approaches to Tunable Optical Materials" MCDB Seminar, UCSB 10/09 Invited...Adaptive Camouflage ”, Alison Sweeney, Daniel DeMartini, Michi Izumi, Amanda Holt, and Daniel E. Morse, presented by Alison Sweeney Reliance 21 Materials

  11. Inflammation in Prostate Carcinogenesis: Role of the Tumor Suppressor Par-4

    Science.gov (United States)

    2012-09-01

    disease in its development and response to therapy (2). Therefore, the development of new therapies and better diagnostic techniques will depend on...better diagnostic techniques will depend on increasing our understanding of the molecular basis of this disease. Genetic loss or mutation of tumor...Izumi Y, Piano F, Kemphues KJ, Miwa J, Ohno S. Atypical protein kinase C cooperates with PAR-3 to establish embryonic polarity in Caenorhabditis

  12. Polypharmacy and adverse drug reactions in Japanese elderly taking antihypertensives: a retrospective database study

    OpenAIRE

    Akazawa, Manabu; Sato, Izumi

    2013-01-01

    Izumi Sato,1 Manabu Akazawa21Department of Epidemiology and Statistics, Graduate School of Medicine, The University of Tokyo Tokyo, Japan; 2Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, JapanBackground: The concomitant use of multiple medications by elderly patients with hypertension is a relatively common and growing phenomenon in Japan. This has been attributed to several factors, including treatment guidelines recommending prescription of multiple me...

  13. The Turbulent Fluxes of Momentum and Sensible Heat over the Open Sea during Moderate to Strong Winds.

    Science.gov (United States)

    1979-08-01

    the overall open ocean situation below about 10 m/s. The "best" constant to use is debatable , but it should be in the range 1.1x10-3 to 1.3x1O- 3 . The...Luftschicht uber des aquatiorialen Atlantik. Neteor Forschungsergebnisse, 1, j: 1-26. aimal, J. C., 3. C. lyngaard, T. Izumi and 0. 1. Cots, 1972

  14. Working group report on simulation and in-situ observation of cement paste fluidity

    OpenAIRE

    Asakura, Etsuro; Tanaka, Hisanobu; Shimosaka, Kenichi; Tsukamoto, Katsuo; Komatsu, Ryuichi; Yoshizaki, Izumi; 朝倉 悦郎; 田中 久順; 下坂 建一; 塚本 勝男; 小松 隆一; 吉崎 泉

    2007-01-01

    We are studying the use of cement on the moon as a building material and the control of its properties, especially fluidity. The viscosity of cement paste in the space may be predicted by the general viscosity equation of Hattori and Izumi based on the DLVO (Derjaguin, Landau, Verway, Overbeek) theory that requires some parameters such as the particle friction coefficient, etc. In situ observation of dispersed particles in cement paste will be a key technology to clarify the mechanisms of the...

  15. Engineering of Specific Tissue Inhibitors to Block ADAM Type Metalloprotease-Mediated Mammary Neoplasia

    Science.gov (United States)

    2001-07-01

    ADAM9 cleaves the HB- EGF when PKCd is activated, but neither the wildtype, nor the dominant-negative ADAM9, affects the EGFR transactivation (Izumi et...S. V. Subramanian, M. L. Fitzgerald, M. Bernfield, J. Bi- that accounts for these observations re- not other TIMPs, induce apoptosis (19). e!. Chem...12. D. Pan and G. M. Rubin, Cell90, 271 (1997). fy the cytoplasmic domains of the pro- and induces apoptosis by binding to the Fas 13. C. Cho et a

  16. Taurid swarm exists only in southern branch (STA)

    Science.gov (United States)

    Shiba, Yasuo

    2016-06-01

    I present some features of the Taurid meteor shower in data obtained by the Japanese automatic TV meteor observation `SonotaCo Network' from 2007 to 2015. (i) The Taurid shower is enhanced when the Earth encounters the Taurid swarm center at less than 30 in mean anomaly as described by Asher and Izumi (1998). A little enhancement was detected in 2011 when it was 71 from the center in mean anomaly. (ii) The Taurid meteor swarm exists only in the southern branch (STA) but not in the northern branch (NTA). (iii) The Taurid meteor swarm includes bright meteors more than the annual year components as also described in Asher & Izumi (1998). (iv) The STA swarm orbital period is equal to the 2:7 resonance with Jupiter. This orbital period agrees with the suggestion in Asher & Izumi (1998). However, the NTA orbital period also matches the 2:7 resonance with Jupiter, though no swarm exists. (v) The Taurid swarm longitude of perihelion is constant at 158 over its whole period. (vi) NTA orbit features vary smoothly over the season. No complex structure could be recognized in NTA in this study of observations by small video camera. (vii) The Taurid swarm orbit differs from the annual STA orbit at its peak, but is close to the annual component at the end of swarm activity. (viii) The annual STA component consists of some similar orbital streams.

  17. QTL Information Table: 158 [Q-TARO

    Lifescience Database Archive (English)

    Full Text Available Physiological trait Eating quality white belly SSR C)Interval DHL Reiho Yamadanishiki A RM163 RM31 jsa Yoshi...da, S., Ikegami, M., Kuze, J., Sawada, K., Hashimoto, Z., Ishii, T., Nakamura, C.,

  18. Great Indoors Awards 2007

    Index Scriptorium Estoniae

    2007-01-01

    Hollandis Maastrichtis jagati 17. XI esimest korda rahvusvahelist auhinda The Great Indoors Award. Aasta sisekujundusfirmaks valiti Masamichi Katayama asutatud Wonderwall. Auhinna said veel Zaha Hadid, Heatherwick Studio, Ryui Nakamura Architects ja Item Idem

  19. Efficacy of some essential oils in mice infected with Trypanosoma cruzi

    African Journals Online (AJOL)

    The groups were evaluated by fresh blood test, blood culture, conventional polymerase chain ..... TBZ group presented null values in all five parameters derived from the ..... Valdez RH, Tonin LT, Ueda-Nakamura T, Silva SO, Dias. Filho BP ...

  20. Sample Set (SE): SE32 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available camaldulensis leaf metabolites. 3 replicates data are examined for each sample. Yukiko Nakamura, Takeshi Ara..., Takashi Matsuura, Mitsuo Enomoto, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Kazusa DNA Research Institute Direct Submittion version 1 ...

  1. Sample Set (SE): SE33 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available leaf metabolites. 3 replicates data are examined for each sample. Yukiko Nakamura, Takeshi Ara, Takashi Mats...uura, Mitsuo Enomoto, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Kazusa DNA Research Institute Direct Submittion version 1 ...

  2. Sample Set (SE): SE22 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available green, orange, red) data are examined. Yoko Iijima 1, Yukiko Nakamura 2, Yoshiyuki Ogata 1, Kenichi Tanaka ...3, Nozomu Sakurai 1, Kunihiro Suda 1, Tatsuya Suzuki 1, Hideyuki Suzuki 1, Koei O

  3. Sample Set (SE): SE36 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available metabolites. 3 replicates data are examined for each sample. Yukiko Nakamura, Takeshi Ara, Takashi Matsuura..., Mitsuo Enomoto, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Kazusa DNA Research Institute Direct Submittion version 1 ...

  4. Sample Set (SE): SE35 [Metabolonote[Archive

    Lifescience Database Archive (English)

    Full Text Available s leaf metabolites. 3 replicates data are examined for each sample. Yukiko Nakamura, Takeshi Ara, Takashi Ma...tsuura, Mitsuo Enomoto, Nozomu Sakurai, Hideyuki Suzuki, Daisuke Shibata, Kazusa DNA Research Institute Direct Submittion version 1 ...

  5. Икебана от икенобо / Николай Караев

    Index Scriptorium Estoniae

    Караев, Николай, 1978-

    2010-01-01

    21. septembril toimus Eesti Rahvusraamatukogus ikebana Ikenobō koolkonna demonstratsioonesinemine. Ikebanakunsti tutvustasid professor Midori Yamada ja Ikenobō Kyōto keskuse külalisprofessor Fukuhiro Nakamura

  6. Икебана от икенобо / Николай Караев

    Index Scriptorium Estoniae

    Караев, Николай, 1978-

    2010-01-01

    21. septembril toimus Eesti Rahvusraamatukogus ikebana Ikenobō koolkonna demonstratsioonesinemine. Ikebanakunsti tutvustasid professor Midori Yamada ja Ikenobō Kyōto keskuse külalisprofessor Fukuhiro Nakamura

  7. EDITORIAL: Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010) Invited papers from ISAMMA 2010 (Sendai, Japan, 12-16 July 2010)

    Science.gov (United States)

    Takahashi, M.; Saito, H.

    2011-02-01

    overseas. The programme involved 4 plenary talks, 37 invited talks, 85 contributed talks and 352 posters. All submitted papers were reviewed in order to meet the standards of Journal of Physics D: Applied Physics and Journal of Physics: Conference Series. We are grateful to all participants for their valuable contributions and active discussions. We gratefully acknowledge the financial support of 17 Japanese companies and 7 Japanese foundations. Invited papers from ISAMMA 2010 Contents Current status and recent topics of rare-earth permanent magnets S Sugimoto Alloying effect on the magnetic properties of RFeB-type bulk magnets H W Chang, C C Hsieh, J Y Gan, Y T Cheng, M F Shih and W C Chang Coercivity distributions in Nd-Fe-B sintered magnets produced by the grain boundary diffusion process H Nakamura, K Hirota, T Ohashi and T Minowa Recent progress in high Bs Fe-based nanocrystalline soft magnetic alloys M Ohta and Y Yoshizawa Electric-field effects on magnetic anisotropy in Pd/Fe/Pd(0 0 1) surface Shinya Haraguchi, Masahito Tsujikawa, Junpei Gotou and Tatsuki Oda Gate modulation of spin precession in a semiconductor channel Hyun Cheol Koo, Jae Hyun Kwon, Jonghwa Eom, Joonyeon Chang, Suk Hee Han and Mark Johnson Ferromagnetic resonance of epitaxial Fe nanodots grown on MgO measured using coplanar waveguides M Mizuguchi and K Takanashi Switching phase diagrams of current-induced magnetization switching in asymmetric MgO-based magnetic tunnel junctions Seung-Young Park, Jae-Ho Han, Se-Chung Oh, Jang-Eun Lee, Kyung-Tae Nam, Hyun-Woo Lee, Younghun Jo and Kyung-Jin Lee Temperature dependence of spin-dependent transport properties of Co2MnSi-based current-perpendicular-to-plane magnetoresistive devices Y Sakuraba, K Izumi, S Bosu, K Saito and K Takanashi Adsorbate-induced spin-polarization enhancement of Fe3O4(0 0 1) A Pratt, M Kurahashi, X Sun and Y Yamauchi Antiferromagnetic coupling between spinel ferrite and α-Fe layers in Fe3-δO4/MgO/Fe(0 0 1) epitaxial films Hideto

  8. An Annotated Bibliography of Studies and Reports Produced by the Advanced Decision Architectures Consortium of the Collaborative Technology Alliance from 2001 to 2010

    Science.gov (United States)

    2010-12-01

    Society Conference. Denver, CO. Jones, L. A., & Nakamura, M. (2003). Haptic Displays: The Tactile Vest. In Proceedings of Collaborative Technology...Multimodal Interfaces (ICMI’02). Pittsburgh, PA. Nakamura, M., & Jones, L. (2003). An Actuator for the Tactile Vest - a Torso-Based Haptic Device. In... Tactile Displays. In Proceedings of IEEE Proceedings of the Symposium on Haptic Interfaces for Virtual Environment and Teleoperator Systems, 33-39

  9. Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome

    OpenAIRE

    Tomatsu S; Sawamoto K; Alméciga-Díaz CJ; Shimada T; Bober MB; Chinen Y; Yabe H; Montaño AM; Giugliani R; Kubaski F; Yasuda E; Rodríguez-López A; Espejo-Mojica AJ; Sánchez OF; Mason RW

    2015-01-01

    Shunji Tomatsu,1,2 Kazuki Sawamoto,1 Carlos J Alméciga-Díaz,3 Tsutomu Shimada,1 Michael B Bober,1 Yasutsugu Chinen,4 Hiromasa Yabe,5 Adriana M Montaño,6 Roberto Giugliani,7 Francyne Kubaski,1,8 Eriko Yasuda,1 Alexander Rodríguez-López,3 Angela J Espejo-Mojica,3 Oscar F Sánchez,9 Robert W Mason,1 Luis A Barrera,3 William&a...

  10. nimpu no LACTOBACILLUS RHAMNOSUS GG yoguruto sesshu ni yoru nyujiki soki no cho nai BIFIDOBACTERIUM zokukin keisei sokushin

    OpenAIRE

    小峰, 由美子

    2014-01-01

    主査 : 舘田一博 / タイトル : Maternal consumption of Lactobacillus rhamnosus GG yogurt during pregnancy promotes bifidobacteria growth in intestinal microflora of infants /著者 : Yumiko Komine, Misa Watanabe, Takehiko Soutome, Koichi Uchino, Takako Uchino, Tsutomu Saji /掲載誌 : 東邦医学会雑誌 /巻号・発行年等 : 61(1):3-12, 2014 /本文ファイル: 出版者版 /

  11. nimpu no LACTOBACILLUS RHAMNOSUS GG yoguruto sesshu ni yoru nyujiki soki no cho nai BIFIDOBACTERIUM zokukin keisei sokushin

    OpenAIRE

    小峰, 由美子

    2014-01-01

    主査 : 舘田一博 / タイトル : Maternal consumption of Lactobacillus rhamnosus GG yogurt during pregnancy promotes bifidobacteria growth in intestinal microflora of infants /著者 : Yumiko Komine, Misa Watanabe, Takehiko Soutome, Koichi Uchino, Takako Uchino, Tsutomu Saji /掲載誌 : 東邦医学会雑誌 /巻号・発行年等 : 61(1):3-12, 2014 /本文ファイル: 出版者版 /

  12. ANTEPRIMA 2013米兰家具展

    Institute of Scientific and Technical Information of China (English)

    2013-01-01

    ANTEPRIMA於2013米兰家具展(Salone de Mobile)期间在米兰Corso Como总店橱窗展出了年轻设计师的Uros Mihic独特摺纸创作。20年前.意大利品牌ANTEPRlMA由日藉设计总监Izumi Ogino所创立。这亦是一次完美的中西合璧之作。ANTEPRIMA每年都为米兰家具展与不同单位或设计师合作,

  13. PREFACE Preface

    Science.gov (United States)

    Takahashi, Migaku; Saito, Hitoshi; Yoshimura, Satoru; Takanashi, Koki; Sahashi, Masashi; Tsunoda, Masakiyo

    2011-01-01

    23 countries, with about 40 percent of participants attending from overseas (see figure). The program involved 4 plenary talks (45 minutes each), 37 invited talks (30 minutes), 85 contributed talks (15 minutes), and 352 posters. Pie chart Organizing Committee of ISAMMA 2010 M TakahashiTohoku Univ., Japan, Chairman K TakanashiTohoku Univ., Japan, Chair of the Program Committee H SaitoAkita Univ., Japan, Chair of the Publication Committee M SahashiTohoku Univ., Japan, Chair of the Treasury Committee M TsunodaTohoku Univ., Japan, General Secretary H AkinagaAIST, Japan H FukunagaNagasaki Univ., Japan K HonoNIMS, Japan S IshioAkita Univ., Japan S IwataNagoya Univ., Japan K NakagawaNihon Univ., Japan S NakagawaTokyo Inst. of Tech., Japan T OnoKyoto Univ., Japan Y SuzukiOsaka Univ., Japan M TanakaEhime Univ., Japan T Tanaka Univ. of Tokyo, Japan Program Committee of ISAMMA 2010 K TakanashiTohoku Univ., Japan, ChairS MizukamiTohoku Univ., Japan M MizuguchiTohoku Univ., Japan, Vice-chairH NaganumaTohoku Univ., Japan M DoiTohoku Univ., JapanS NakagawaTokyo Inst. of Tech., Japan A FujitaTohoku Univ., JapanK NakamuraTohoku Univ., Japan K IshiyamaTohoku Univ., JapanK OnoKEK, Japan T KatoNagoya Univ., JapanT OnoKyoto Univ., Japan T KawagoeOsaka Pref. Univ.of Edu., JapanF SatoTohoku Univ., Japan O KitakamiTohoku Univ., JapanM ShiraiTohoku Univ., Japan Y KitamotoTokyo Inst. of Tech., JapanS SugimotoTohoku Univ., Japan F MatsukuraTohoku Univ., JapanM YamaguchiTohoku Univ., Japan C MitsumataHitachi Metals, Japan Publication Committee of ISAMMA 2010 H SaitoAkita Univ., Japan, ChairS MitaniNIMS, Japan S YoshimuraAkita Univ., Japan, Vice-chairH MuraokaTohoku, Japan Y AndoTohoku Univ., JapanM NakanoNagasaki Univ., Japan J AriakeAIT, JapanR NakataniOsaka Univ., Japan H AsanoNagoya Univ., JapanK O'GradyUniv. of York, UK M FutamotoChuo Univ., JapanA SakumaTohoku Univ., Japan J HayakawaHitachi, ARL, JapanT SatoKeio Univ., Japan T HondaKyushu Inst. of Tech., JapanT SatoShinshu Univ., Japan M

  14. Estimation of damping ratio of soil sites using microtremor

    Institute of Scientific and Technical Information of China (English)

    郭迅; 黄玉龍; 袁一凡

    2002-01-01

    It is widely known that the seismic response characteristics of a soil site depends heavily on several key dynamicproperties of the soil stratum, such as predominant frequency and damping ratio. A widely used method for estimating thepredominant frequency of a soil site by using microtremor records, proposed by Nakamura, is investigated to determine itseffectiveness in estimating the damping ratio. The authors conducted some microtremor measurements of soil sites in HongKong and found that Nakamura's method might also be used to estimate the damping ratio of a soil site. Damping ratio datafrom several typical soil sites were obtained from both Nakamura's ratio curves using the half power point method and resonantcolumn tests. Regression analysis indicates that there is a strong correlation between the damping ratios derived from thesetwo different approaches.

  15. Proceedings of the 1997 IEEE International Symposium on Compound Semiconductors (1997) Held in San Diego, California, on 8-11 September 1997

    Science.gov (United States)

    1998-05-01

    the Future’ and Shuji Nakamura from Nichia Chemical Industries who spoke on ’III-V Nitride Based Blue/Green LEDs and LDs’. The chapters are organized...E Pyun and H-M Park 455 An Au/Pt/Ti/WN* ohmic contact to n-InGaAs and its application to AlGaAs/GaAs HBTs 5 H Park, I-H Kim, T-W Lee and M-P Park...Nitride-Based Blue LDs with Modulation-Doped Strained-Layer Superlattices S. Nakamura R&D Department, Nichia Chemical Industries, Ltd., 491 Oka

  16. Background story of the invention of efficient blue InGaN light emitting diodes

    Energy Technology Data Exchange (ETDEWEB)

    Nakamura, Shuji [University of California, Santa Barbara, CA (United States)

    2015-06-15

    Shuji Nakamura discovered p-type doping in Gallium Nitride (GaN) and developed blue, green, and white InGaN based light emitting diodes (LEDs) and blue laser diodes (LDs). His inventions made possible energy efficient, solid-state lighting systems and enabled the next generation of optical storage. Together with Isamu Akasaki and Hiroshi Amano, he is one of the three recipients of the 2014 Nobel Prize in Physics. In his Nobel lecture, Shuji Nakamura gives an overview of this research and the story of his inventions. (copyright 2015 by WILEY-VCH Verlag GmbH and Co. KGaA, Weinheim)

  17. The Distribution, Levels, and Relevance of the Interleukin-1 Family of Cytokines and Receptors in Human Breast Carcinoma-Induced Osteolysis

    Science.gov (United States)

    2005-10-01

    1974;290(16):867-71. 15. Jimi E, Ikebe T, Takahashi N, Hirata M, Suda T, Koga T. Interleukin-1 alpha activates an NF- kappaB-like factor in osteoclast-like...cells. J Biol Chem 1996;271(9):4605-8. 16. Jimi E, Nakamura I, Duong LT, Ikebe T, Takahashi N, Rodan GA, et al. Interleukin 1 induces...TNF alpha. J Dent Res 1999;78(10):1617-23. 19. Jimi E, Nakamura I, Ikebe T, Akiyama S, Takahashi N, Suda T. Activation of NF-kappaB is involved in the

  18. A Facile Synthesis of Two Sesquiterpenes Methyl Ether

    Institute of Scientific and Technical Information of China (English)

    DU Zhen-Ting; ZHANG Yan-Mei; WANG Zi-Kun; WU Tong-Xing; PAN Xin-Fu

    2003-01-01

    @@ Bisabolane sesquiterpenes are a big family of naturally occurring products with significantly biological activities most of which can be separated from Chinese traditional medicines. Parahigginone (1a) was firstly separated as a bisabolane by Shen Y. C. et al. from the Taiwan marine sponges in 1999, [1] it shows very promising antitumor activity.[1] As far as we know, there is no synthetic report on it. Curcuphenol (2a) was a cytotoxic sesquiterpene which was first discovered in Pseudopterogorgia rigida[2,3] which has been synthesized by Frank[2] and Tsutomu[4] before. In order to study the relationship between the structures and the activities, we have synthesized parahiggi none methyl ether (1) and curcuphenol methyl ether (2) in six steps successfully, and the stereoselective synthesis is carried out in progress.

  19. Assessing the Short-Term Effects on Output of Changes in Federal Fiscal Policies (Working Paper Series)

    Science.gov (United States)

    2012-05-01

    in state budget practices , including variations in their balanced-budget requirements; Nakamura and Steinsson (2011) study regional variations in...Balancing Fiscal Policy Risk, Washington, D.C. Appendix 1. Leeper, Eric M. 2010. “Monetary Science, Fiscal Alchemy .” in Macroeconomic Challenges: The

  20. Autocorrelation in queuing network type production systems - revisited

    DEFF Research Database (Denmark)

    Nielsen, Erland Hejn

    -production systems (Takahashi and Nakamura, 1998) establishes that autocorrelation plays definitely a non-negligible role in relation to the dimensioning as well as functioning of Kanban-controlled production flow lines . This must logically either imply that production managers are missing an important aspect...

  1. Bioamines in Stress.

    Science.gov (United States)

    1976-12-01

    Ph.D. Visiting Instructor L.C. Mills , M.D. Professor 3.L. Osterhoim, M.D. Professor JT. Ponessa, Ph.D. Assistant Professor E.A. Reed, Ph.D...Y. Nakamura and J.J. Spitzer. “Arterial Concentration and Cerebral Removal of Metabolites in Fasting Puppies ”. Amer. 5. Physiol. 225 :967—97], , 1973

  2. 76 FR 11351 - Non-Vessel-Operating Common Carrier Negotiated Rate Arrangements

    Science.gov (United States)

    2011-03-02

    ... relieve licensed NVOCCs from the costs and burdens of tariff rate publication. Licensed NVOCCs, to the..., Inc.; M.E. Dey & Co., Inc.; Nakamura (USA) Inc.; CV International; Mohawk Global Logistics; NACA Logistics (USA) Inc. d/b/a Vanguard Logistics Services; BDP Transport, Inc., CaroTrans International, Inc...

  3. HTLV-1 Tax Effects on Cellular Mitotic Regulation

    Science.gov (United States)

    2007-04-12

    2A inhibition, and anticancer activity. Bioorg Med Chem Lett 14:1969-73. 61. Hasegawa, H., H. Sawa , M. J. Lewis, Y. Orba, N. Sheehy, Y. Yamamoto, T...3. Cell 75:653-60. 131. Miyamoto, K., N. Tomita, A. Ishii , T. Nishizaki, K. Kitajima, T. Tanaka, T. Nakamura, S. Watanabe, and T. Oda. 1984

  4. 76 FR 3642 - National Human Genome Research Institute; Notice of Closed Meetings

    Science.gov (United States)

    2011-01-20

    ... applications. Place: Crystal Gateway Marriott, 1700 Jefferson Davis Highway, Arlington, VA 22202. ] Contact... Inn by Marriott, 7335 Wisconsin Avenue, Bethesda, MD. Contact Person: Ken D. Nakamura, PhD, Scientific... applications. Place: Bethesda Residence Inn by Marriott, 7335 Wisconsin Avenue, Bethesda, MD 20814....

  5. A Remark on the Lifshitz Tail for Schrödinger Operator with Random Magnetic Field

    Indian Academy of Sciences (India)

    Shu Nakamura

    2002-02-01

    In this note, we consider the Lifshitz singularity for Schrödinger operator with ergodic random magnetic field. A key estimate is an energy bound for magnetic Schrödinger operators as discussed in Nakamura [8]. Here we remove a technical assumption in [8], namely, the uniform boundedness of the magnetic field.

  6. First-Principles Study of Defects in GaN, AlN and Their Alloys

    Science.gov (United States)

    2010-08-31

    Physics 76, 1363 (1994). [7] F. A. Ponce and D. P. Bour, Nature 386, 351 (1997). [8] S. Nakamura, M. Senoh, S.-i. Nagahama, N. Iwasa, T. Yamada, T...Phys. Rev. Lett. 100 (2008) 167402. [7] K.R. Reyes -Gil, E.A. Reyes -Garcia, D. Raftery, J. Phys. Chem. C 111 (2007) 14579. [8] Motlan, E.M. Goldys

  7. Finite-time Control of One-link Mechanical System

    Science.gov (United States)

    Matoba, Shunsuke; Nakamura, Nami; Nakamura, Hisakazu; Akiba, Hideyuki

    This paper considers finite-time position control of an one-link mechanical system. The system is modeled by discontinuous differential equations. In this paper, we prove that the Nakamura's local homogeneous controller based on a control Lyapunov function is valid to the position control of the robot manipulators, and show the effectiveness of the controller by experiments.

  8. Efficacy of an aspiration device with distal protection for the treatment in acute myocardial infarction

    Institute of Scientific and Technical Information of China (English)

    Naoto Inoue

    2003-01-01

    @@ Hiroshi Fujita Kenji Suzuki Akiko Matsuo Reo Nakamura Tetsuya Tanaka Keiji Inoue Hisayuki Hyogo Takaomi Tokura Objective Percutaneous coronary interventions in the setting of acute myocardial infarction(AMI)have been associated with increased risk of distal embolization and no-reflow phenomenon. To evaluate the efficacy and feasibility of a distal protection using the PercuSurge Guardwire Plus( PSG) in AMI.

  9. Reexamination of Ionospheric Chemistry: High Temperature Kinetics, Internal Energy Dependences, Unusual Isomers, and Corrections

    Science.gov (United States)

    2006-01-01

    C6F6 (9%), CS2 (17%), CF3 I (55%), C3F6 heats of formation. Since the thermochemistry of the neutrals(73%), OCS (59%), Xe (97%), SO2 (55%), 03 (98%), N...Fehsenfeld for 30 S. Matsuoka, H. Nakamura and T. Tamura, J. Chem. Phys., teaching me the joys of ionospheric chemistry and providing 1983, 79, 825. the

  10. Applications of Molecular and Materials Modeling

    Science.gov (United States)

    2002-01-01

    nittalabo-e.html Osaka University, Institute for Protein Research Protein modeling Prof. Haruki Nakamura http://www.protein.osaka- u.ac.jp/kessho/members...band structure of YH3. Phys. Rev. B 61, 16491- 16496. Nagashima, U., S. Obara, K. Murakami , T. Yoshii, S. Shirakawa, T. Amisake, K. Kitamura, O. Kitao

  11. Keemia- ja füüsikapreemiate märksõna on valgus / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2014-01-01

    Nobeli keemiapreemia pälvisid sakslane Stefan Hell ning ameeriklased Eric Betzig ja William Moerner, kes leidsid viisi, kuidas uurida valgusmikroskoobiga eluslooduse pisimaid komponente. Füüsikapreemia pälvisid Jaapani teadlased Isamu Akasaki, Hiroshi Amano ja Shuji Nakamura sinise valgusdioodi leiutamise eest

  12. 75 FR 8977 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-02-26

    ... HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Notice of Closed.... Nakamura, PhD, Scientific Review Officer, Scientific Review Branch, National Human Genome Research...-402-0838. (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome...

  13. 75 FR 67380 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2010-11-02

    ... HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Notice of Closed...: Ken D. Nakamura, PhD, Scientific Review Officer, Scientific Review Branch, National Human Genome... Program Nos. 93.172, Human Genome Research, National Institutes of Health, HHS) Dated: October 26,...

  14. 76 FR 10909 - National Human Genome Research Institute; Notice of Closed Meeting

    Science.gov (United States)

    2011-02-28

    ... HUMAN SERVICES National Institutes of Health National Human Genome Research Institute; Notice of Closed.... Nakamura, PhD, Scientific Review Officer, Scientific Review Branch, National Human Genome Research...-402-0838. (Catalogue of Federal Domestic Assistance Program Nos. 93.172, Human Genome...

  15. Repeatability in Redundant Manipulator Systems

    Science.gov (United States)

    1994-02-22

    IEEE Transactions on Robotics and Automation...34Nonholonomic Motion Planning of Space Robots via a Bi-Directional Approach", IEEE Transactions on Robotics and Automation, Vol. 7, No. 4, pp. 500-514. [12...Nakamura, Y., and Mukherjee, R., 1993, "Exploiting Nonholonomic Redundancy in Free-Flying Space Robots", IEEE Transactions on Robotics and Automation,

  16. Dynamic Coupling of Underactuated Manipulators

    Science.gov (United States)

    1994-08-01

    using dynamic coupling. IEEE Transactions on Robotics and Automation, vol. 7, no. 4, Aug. 1991, pp. 528-534. [2] Bergerman, M.; Xu, Y. Robust control of...equilibrium manifolds. IEEE Transactions on Robotics and Automation, vol. 9, no. 5, Oct. 1993. [8] Nakamura, Y. Advanced robotics: Redundancy and

  17. READINGS IN JAPANESE HISTORY. PART I, SELECTIONS.

    Science.gov (United States)

    YAMAGIWA, JOSEPH K.

    INCLUDED AMONG THE 18 SELECTIONS IN THIS READER FOR ADVANCED STUDENTS OF JAPANESE ARE SUCH ARTICLES AND EXCERPTS FROM BOOKS AS "THE TAIKA REFORMS" BY SAKAMOTO TAROO (1935) AND "THE SYSTEM OF MEASUREMENT OF INCOME BY KOKU AND FEUDALISM" BY NAKAMURA KICIJI (1960). THESE TEXTS ARE REPRODUCED EXACTLY AS THEY APPEARED IN JAPANESE-LANGUAGE PUBLICATIONS…

  18. Disease: H00916 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available H00916 Congenital central hypoventilation syndrome (CCHS) Congenital central hypoventilation...zumi T, Kusuda S, Ogawa Y, Tuchiya K, Yamamoto W, Nakamura T, Hayasaka K Molecular analysis of congenital central hypoventilation...oradrenergic neuronal development is impaired by mutation of the proneural HASH-1 gene in congenital central hypoventilation

  19. Keemia- ja füüsikapreemiate märksõna on valgus / Arko Olesk

    Index Scriptorium Estoniae

    Olesk, Arko, 1981-

    2014-01-01

    Nobeli keemiapreemia pälvisid sakslane Stefan Hell ning ameeriklased Eric Betzig ja William Moerner, kes leidsid viisi, kuidas uurida valgusmikroskoobiga eluslooduse pisimaid komponente. Füüsikapreemia pälvisid Jaapani teadlased Isamu Akasaki, Hiroshi Amano ja Shuji Nakamura sinise valgusdioodi leiutamise eest

  20. Revealing the Functions of Tenascin-C in 3-D Breast Cancer Models Using Cell Biological and In Silico Approaches

    Science.gov (United States)

    2007-03-01

    the malignant phenotype. Cancer Cell 2005;8(3):241-54. 25. Ferguson JE, Schor AM, Howell A, Ferguson MW. Tenascin distribution in the normal human...Sci U S A 2005;102(12):4324-9. 78. Soriano JV, Pepper MS, Nakamura T, Orci L, Montesano R. Hepatocyte growth factor stimulates extensive development

  1. Reference: SURECOREATSULTR11 [PLACE

    Lifescience Database Archive (English)

    Full Text Available Yamaya T, Takahashi H. Identification of a novel cis-acting element conferring sulfur deficiency response in Arabidopsis roots. Plant J. 42: 305-314 (2005). PubMed: 15842617 ... ...SURECOREATSULTR11 Maruyama-Nakashita A, Nakamura Y, Watanabe-Takahashi A, Inoue E,

  2. Numerical Simulation of a Nanosecond Pulse Discharge in Mach 5 Flow

    Science.gov (United States)

    2013-01-01

    Diffusion and Drift of Electrons in Gases, Wiley, New York, 1974. 31Itikawa, Y., Hayashi, M., Ichimura, A., Onda , K., Sakimoto, K., Takayanagi, K., Nakamura...Chemical Reference Data, Vol. 16, 1986, pp. 985–1010. 32Itikawa, Y., Ichimura, A., Onda , K., Sakimoto, K., Takayanagi, K., Hatano, Y., Hayashi, M

  3. Pure Rotational CARS Thermometry Studies of Low Temperature Oxidation Kinetics in Air and Ethene-Air Nanosecond Pulse Discharge Plasmas

    Science.gov (United States)

    2010-01-01

    Electrons in Gases”, Wiley, New York. [25] Itikawa Y, Hayashi M, Ichimura A, Onda K, Sakimoto K, Takayanagi K, Nakamura M, Nishimura M and Takayanagi T...A, Onda K, Sakimoto K, Takayanagi K, Hatano Y, Hayashi M, Nishimura H, and Tsurubichi S, J. 1989 Cross Sections for Collisions of Electrons and

  4. Stability and Index of the Meet Game on a Lattice

    OpenAIRE

    Joseph Abdou

    2012-01-01

    We study the stability and the stability index of the meet game form defined on a meet semilattice. Given any active coalition structure, we show that the stability index relative to the equilibrium, to the beta core and to the exact core is a function of the Nakamura number, the depth of the semilattice and its gap function.

  5. The Preliminary Study on Procurement Biliary Convergence from Donors with Complicated Bile Duct Variant in Emergency Right Lobe Living Donor Liver Transplantation.

    Science.gov (United States)

    Ye, Sheng; Dong, Jia-Hong; Duan, Wei-Dong; Ji, Wen-Bing; Liang, Yu-Rong

    2017-03-01

    The incidence of biliary complications after living donor adult liver transplantation (LDALT) is still high due to the bile duct variation and necessity reconstruction of multiple small bile ducts. The current surgical management of the biliary variants is unsatisfactory. We evaluated the role of a new surgical approach in a complicated hilar bile duct variant (Nakamura type IV and Nakamura type II) under emergent right lobe LDALT for high model for end-stage liver disease score patients. The common hepatic duct (CHD) and the left hepatic duct (LHD) of the donor were transected in a right-graft including short common trunks with right posterior and anterior bile ducts, whereas the LHD of the donor was anastomosed to the CHD and the common trunks of a right-graft bile duct and the recipient CHD was end-to-end anastomosed. Ten of 13 grafts (Nakamura types II, III, and IV) had two or more biliary orifices after right graft lobectomy; seven patients had biliary complications (53.8%). Later, the surgical innovation was carried out in five donors with variant bile duct (four Nakamura type IV and one type II), and, consequently, no biliary or other complications were observed in donors and recipients during 47-53 months of follow-up; significant differences (P right hepatic ducts in a complicated donor bile duct variant may facilitate biliary reconstruction and reduce long-term biliary complications.

  6. Association Between Sexual Health and Delivery Mode

    Directory of Open Access Journals (Sweden)

    Mihyon Song, MD

    2014-12-01

    Conclusion: This study suggests that routine episiotomies at delivery should be avoided to improve postpartum maternal sexual function. Maternal age and cesarean section were found to affect postpartum sexual health. Song M, Ishii H, Toda M, Tomimatsu T, Katsuyama H, Nakamura T, Nakai Y, and Shimoya K. Association between sexual health and delivery mode. Sex Med 2014;2:153–158.

  7. On the permutation combinatorics of worldsheet moduli space

    CERN Document Server

    Freidel, Laurent; Ramgoolam, Sanjaye

    2014-01-01

    Light-cone string diagrams have been used to reproduce the orbifold Euler characteristic of moduli spaces of punctured Riemann surfaces at low genus and with few punctures. Nakamura studied the meromorphic differential introduced by Giddings and Wolpert to characterise light-cone diagrams and introduced a class of graphs related to this differential. These Nakamura graphs were used to parametrise the cells in a light-cone cell decomposition of moduli space. We develop links between Nakamura graphs and realisations of the worldsheet as branched covers. This leads to a development of the combinatorics of Nakamura graphs in terms of permutation tuples. For certain classes of cells, including those of top dimension, there is a simple relation to Belyi maps, which allows us to use results from Hermitian and complex matrix models to give analytic formulae for the counting of cells at arbitrarily high genus. For the most general cells, we develop a new equivalence relation on Hurwitz classes which organises the cell...

  8. Autocorrelation in queuing network type production systems - revisited

    DEFF Research Database (Denmark)

    Nielsen, Erland Hejn

    -production systems (Takahashi and Nakamura, 1998) establishes that autocorrelation plays definitely a non-negligible role in relation to the dimensioning as well as functioning of Kanban-controlled production flow lines . This must logically either imply that production managers are missing an important aspect...

  9. Disease: H01300 [KEGG MEDICUS

    Lifescience Database Archive (English)

    Full Text Available son I, Lord GM, Gibbs JS, Wilkins MR, Ohta-Ogo K, Nakamura K, Girerd B, Coulet F, Soubrier F, Humbert M, Morrell NW, Trembath...R, Phillips JA 3rd, Loyd JE, Nichols WC, Trembath RC Heterozygous germline mutati

  10. Retrospective study on temporal and regional variations of methylmercury concentrations in preserved umbilical cords collected from inhabitants of the Minamata area, Japan.

    Science.gov (United States)

    Sakamoto, Mineshi; Murata, Katsuyuki; Tsuruta, Kazuhito; Miyamoto, Kenichiro; Akagi, Hirokatsu

    2010-09-01

    The present study was conducted to investigate the historical time-course changes and regional distribution of methylmercury concentrations in preserved umbilical cords collected from Minamata-area inhabitants born between 1947 and 1989. The data from Miyazaki, Tottori, Akita, Tsushima (Nagasaki), Fukuoka and Tokyo were used as controls. A total of 325 data were analyzed to estimate the temporal and spatial distribution of methylmercury among inhabitants born in the Minamata area. Elevated methylmercury concentrations (>or=1 microg/g) were mainly observed in inhabitants born between 1947 and 1968. That peak coincided with the peak of acetaldehyde production in Minamata. The methylmercury concentrations started to decrease in keeping with the decline of acetaldehyde production, which ceased in 1968, and thereafter the methylmercury levels gradually decreased to the control levels. Elevated methylmercury concentrations were first observed in the districts of Minamata, followed by Izumi, Tsunagi and Ashikita, indicating the time-course-dependent regional distributions of methylmercury pollution.

  11. On Invariant MASAs for Endomorphisms of the Cuntz Algebras

    CERN Document Server

    Skalski, Jeong Hee Hong Adam

    2010-01-01

    The problem of existence of standard (i.e. product-type) invariant MASAs for endomorphisms of the Cuntz algebra O_n is studied. In particular endomorphisms which preserve the canonical diagonal MASA D_n are investigated. Conditions on a unitary in O_n equivalent to the fact that the corresponding endomorphism preserves D_n are found, and it is shown that they may be satisfied by unitaries which do not normalize D_n. Unitaries giving rise to endomorphisms which leave all standard MASAs invariant and have identical actions on them are characterized. Finally some properties of examples of finite-index endomorphisms of O_n given by Izumi and related to sector theory are discussed and it is shown that they lead to an endomorphism of O_2 associated to a matrix unitary which does not preserve any standard MASA.

  12. On invariant MASAs for endomorphisms of the Cuntz algebras

    DEFF Research Database (Denmark)

    Hong, Jeong Hee; Skalski, Adam; Szymanski, Wojciech

    2010-01-01

    The problem of existence of standard (i.e. product-type) invariant MASAs for endomorphisms of the Cuntz algebras O_n is studied. In particular, endomorphisms which preserve the canonical diagonal MASA D_n are investigated. Conditions on a unitary w equivalent to the fact that the corresponding...... endomorphism λ_w preserves D_n are found, and it is shown that they may be satisfied by unitaries which do not normalize D_n. Unitaries giving rise to endomorphisms which leave all standard MASAs invariant and have identical actions on them are characterized. Finally, some properties of examples of finite......-index endomorphisms of O_n given by Izumi and related to sector theory are discussed and it is shown that they lead to an endomorphism of O_2 associated to a matrix unitary which does not preserve any standard MASA....

  13. 照亮21世纪的新型光源--2014年诺贝尔物理学奖介绍%The new light source shining 21 century:A brief introduction to the Nobel Prize in Physics 2014

    Institute of Scientific and Technical Information of China (English)

    潘笃武

    2014-01-01

    The Nobel Prize in Physics 2014 rewarded to Isamu Akasaki, Hiroshi Amano and Shuji Nakamura as they have invented the blue light-emitting diode (LED). It is a new energy-efficient and environment-friendly light source. The Laureates’research works and achievements are introduced briefly in this article . The physical principle and structure of the blue light-emitting diode are described sketchily.%2014年的诺贝尔物理学奖颁给发明蓝色发光二极管的赤崎勇(Isamu Akasaki)、天野浩(Hiroshi Amano)和中村修二(Shuji Nakamura)。简单介绍了获奖者的研究工作及成就,并简略描述了蓝色发光二极管的物理原理和结构。

  14. Is There Contextuality for a Single Qubit?

    Science.gov (United States)

    Grudka, Andrzej; Kurzyński, Paweł

    2008-04-01

    Cabello and Nakamura have shown [A. Cabello, Phys. Rev. Lett. 90, 190401 (2003)PRLTAO0031-900710.1103/PhysRevLett.90.190401] that the Kochen-Specker theorem can be applied to two-dimensional systems if one uses positive operator-valued measures (POVM). We show that the contextuality in their models is not of the Kochen-Specker type, but it is rather a result of not keeping track of the whole system on which the measurement is performed. This is connected to the fact that there is no one-to-one correspondence between the POVM elements and projectors on the extended Hilbert space, and the same POVM element has to originate from two different projectors when used in Cabello-Nakamura models. Moreover, we propose a hidden-variable formulation of the above models.

  15. JPRS Report, Science & Technology, Japan, 1989 S&T Agency Annual 33

    Science.gov (United States)

    2007-11-02

    34 Isamu Yamashita " Jiro Kondo " Hiroshi Inose " Kunio Kagayama «• Machiro Kawada •• Masakazu Sawa " Eiji Suzuki *’ Saburo Nagakura " Hiromichi...Nagata 10 June 1988 T Toshihiro Ishii 10 June 1988 A Accounting Division Manager Akira Takeda 10 June 1988 T Hiroto Sekida 10 June 1988 A Science...Division Manager Toshihiro Ishii 10 June 1988 M (General Affairs Division Man- ager) Mitsuhiro Nakamura 10 June 1988 A Planning Division Manager

  16. Ultrastructure Processing and Environmental Stability of Advanced Structural and Electronic Materials

    Science.gov (United States)

    1992-08-31

    Chemical & mechanical be- havior of Bioglass coated alumina. J. Biomed. Mater. Res. REFERENCES 10:503; 1976. 13. Kitsugi. T.; Yamamuro , T.: Nakamura...of Orthopedic Kitsuigi. T.: and Yamamuro . T. Ca. P-rich layer formed on Implants. Williams, D. F, ed.. Boca Ralon:CRC Press: high -strength bloactive...Biomedical Maters. Res., 1980, 14, 55-64. 14. Kokubo, T. In Handbook of Bioactive Ceramics, Vol. I, Yamamuro , T., Hench, L. L. and Wilson, J., eds

  17. Evaluating a Novel Sleep-Focused Mind-Body Rehabilitative Program for Veterans with mTBI and Other Polytrauma Symptoms: An RCT Study

    Science.gov (United States)

    2015-09-01

    34 Polytrauma " Symptoms: An RCT Study PRINCIPAL INVESTIGATOR: Yoshio Nakamura, Ph.D. CONTRACTING ORGANIZATION: University of Utah , Salt Lake City, UT 84112...Rehabilitative Program for Veterans with mTBI and Other " Polytrauma " Symptoms: An RCT Study 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S...our recruiting effort. We screened the patient lists obtained from Polytrauma Clinic at VA, sent recruitment letters and made phone calls to follow

  18. Outdoor Synthetic Aperture Acoustic Ground Target Measurements

    Science.gov (United States)

    2010-04-19

    1341 (2003). [11] C. A. Dimarzio, T. Shi, F. J. Blonigen et al., “ Laser -Induced Acoustic Landmine Detection,” The Journal Of The Acoustical Society...High Frequency A/S Coupling For Ap Buried Landmine Detection Using Laser Doppler Vibrometers,” Proc. SPIE 5415(1), 35-41 (2004). [16] Bishop, S... Dolphin Echolocation Clicks For Target Discrimination,” The Journal Of The Acoustical Society Of America 124(1), 657-666 (2008). [20] Y. Nakamura

  19. United States Air Force Summer Research Program -- 1993. Volume 7. Armstrong Laboratory

    Science.gov (United States)

    1993-12-01

    includes; mastitis in cows, pneumonia in gnotobiotic calves, vulvitis and conjunctitivis. Virulent and avirulent strains have been described. (4...Physiology (Heart, Circ. Physiol. 14), H733-H780, 1983. Sunagawa, K., Yamada, A., Senda, Y., Kikuchi, Y., Nakamura, M., Shibahara, T., Nose , Y...guns. The major sheetmetal tasks observed consisted of repairing the following: i) B-52 nose cowls, 2) remove skin - wrap panel B-52, 3) install skin

  20. International Conference on Positron Annihilation (6th) held at the University of Texas at Arlington, April 3-7, 1982. Program and Collected Abstracts.

    Science.gov (United States)

    1983-02-23

    PUFF P-149 Positron Annihilation Studies of Zeolites Encapsulating High Pressure of Krypton YASUO ITO, TAKEMI TAKANO, HIRONAO KOJIMA, SHINGO MATSUOKA...HIRONE NAKAMURA, and TAKAAKI TAMURA P-150 A Study of Positron Annihilation in Cyclodextrins P.K. TSENG, K.S. CHEN, and S.Y. CHUANG P-150A Distribution...1981) and submitted to Nuclear Instruments and Methods J 292 P-149 POSITRON ANNIHILATION STUDIES OF ZEOLITES ENCAPSULATING HIGH PRESSURE OF KRYPTON

  1. Epoprostenol sodium for treatment of pulmonary arterial hypertension

    OpenAIRE

    Saito Y.; Nakamura K; Akagi S; Sarashina T; Ejiri K; Miura A; Ogawa A.; Matsubara H; Ito H

    2015-01-01

    Yukihiro Saito,1 Kazufumi Nakamura,1 Satoshi Akagi,1 Toshihiro Sarashina,1 Kentaro Ejiri,1 Aya Miura,1 Aiko Ogawa,2 Hiromi Matsubara,2 Hiroshi Ito1 1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; 2Division of Cardiology, National Hospital Organization Okayama Medical Center, Okayama, Japan Abstract: The release of endogenous prostacyclin (PGI2) is depressed in patients with pulmonary arterial hyper...

  2. Integration of inhomogeneous cosmological spacetimes in the BSSN formalism

    CERN Document Server

    Mertens, James B; Starkman, Glenn D

    2015-01-01

    We present cosmological-scale numerical simulations of an evolving universe in full general relativity (GR) and introduce a new numerical tool, {\\sc CosmoGRaPH}, which employs the Baumgarte-Shapiro-Shibata-Nakamura (BSSN) formalism on a 3-dimensional grid. Using {\\sc CosmoGRaPH}, we calculate the effect of an inhomogeneous matter distribution on the evolution of a spacetime. We also present the results of a set of standard stability tests to demonstrate the robustness of our simulations.

  3. Stemcell Information: SKIP000648 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学研...究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information Only RIKEN BioResource Center 理化学

  4. Stemcell Information: SKIP000646 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ing and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学研究所バイオリ...ソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information Only RIKEN BioResource Center 理化学

  5. Stemcell Information: SKIP000636 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available FGF ... 3% Negative ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学研究所バイオリソースセンター RI...KEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Available RIKEN BioResource Center 理化学

  6. Database Description - MicrobeDB.jp | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available nter for Information Biology, National Institute of Genetics Journal Search: Crea...tor Name: Yasukazu Nakamura Creator Affiliation: Center for Information Biology, National Institute of Genetics Journal... Search: Creator Name: Ikuo Uchiyama Creator Affiliation: National Institute for Basic Biology Journal...ion Biology, National Institute of Genetics Journal Search: Creator Name: Takatomo Fujisawa Creator Affiliat...ion: Center for Information Biology, National Institute of Genetics Journal Search: Creator Name: Hirokazu C

  7. Sisekujunduse maailmameistrid / Lylian Meister

    Index Scriptorium Estoniae

    Meister, Lylian, 1966-

    2008-01-01

    Hollandis 2007. a. novembris esmakordselt toimunud rahvusvahelisest sisearhitektuurikonkursist The Great Indoors Award. Aasta sisekujundusfirmaks valiti Masamichi Katayama asutatud Wonderwall. Ülejäänud auhinnad said Zaha Hadid Hispaanias asuva R.Lopez de Heredia veinidegusteerimise keskuse kujunduse eest, Heatherwick Studio East Beach Cafe kujunduse eest Inglismaal, Ryui Nakamura Architects Jins Global Standard prillipoe kontseptuaalse lahenduse eest Tokyos ja Item Idem Bernhard Willhelmi moebrändi esindusbutiigi kujunduse eest Tokyos

  8. Hepatoprotective effects of antioxidants in chronic hepatitis C

    Institute of Scientific and Technical Information of China (English)

    Ricardo; Moreno-Otero; María; Trapero-Marugán

    2010-01-01

    We have read with interest the paper published in issue 2, volume 16 of World Journal of Gastroenterology 2010 by Nakamura et al, demonstrating that the antioxidant resveratrol (RVT) enhances hepatitis C virus (HCV) replication, consequently, they conclude that RVT is not a suitable antioxidant therapy for HCV chronic infection. The data raise some concern regarding the use of complementary and alternative medicine since the most frequent supplements taken by these patients are antioxidants or agents that m...

  9. Fast Response Liquid Crystal Mode

    Science.gov (United States)

    2011-04-19

    Journal of Applied Physics , vol. 39, No. 6A, Jun. 1, 2000, pp. 527-530. Hajime...Nakamura, et a!., "Bend Transition in Pi-cell" Journal of Applied Physics , vol. 39, No. 11, Nov. 1, 2000, pp. 6368-6375. "Electro-Optical Performance of a...Characteristic of Fringe-Field Switching Mode Depending on Rubbing Direction," S.H. Hong et a!, Journal of Applied Physics vol. 39, No. 6A, Jun. 1, 2000,

  10. Ultrafast spectroscopy of wide bandgap semiconductor nanostructures

    OpenAIRE

    2015-01-01

    Group III-nitrides have been considered a promising choice for the realization of optoelectronic devices since 1970. Since the first demonstration of the high-brightness blue light-emitting diodes (LEDs) by Shuji Nakamura and coworkers, the fabrication of highly efficient white LEDs has passed successful developments. A serious physical issue still remained, which prevents their use for high power and highly efficient LEDs: the drop of external quantum efficiency (EQE) of III-nitride LEDs whe...

  11. The reasons for triple therapy in stable COPD patients in Japanese clinical practice

    OpenAIRE

    Miyazaki M; Nakamura H; Takahashi S; Chubachi S; Sasaki M.; Haraguchi M; Terai H; Ishii M; Fukunaga K; Tasaka S; Soejima K; Asano K.; Betsuyaku T

    2015-01-01

    Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio COPD Comorbidity Research (K-CCR) group 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, 3Division of Pulmonary Medici...

  12. Spreading Depressions as Secondary Insults after Traumatic Injury to the Human Brain

    Science.gov (United States)

    2012-09-01

    aneurysmal subarachnoid haemorrhage, depolarisations with depression periods longer than 10 min had worse outcomes at discharge and the rate of...is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain 2009; 132: 1866–81. 17 Nakamura H, Strong... Pediatrics ), Harvard Medical School and Children’s Hospital Boston, Boston, MA, USA 1 Hartings JA, Bullock MR, Okonkwo DO, et al. Spreading

  13. The G-Hilbert scheme for 1/r(1,a,r-a)

    CERN Document Server

    Kedzierski, Oskar

    2010-01-01

    Following Craw, Maclagan, Thomas and Nakamura work on Hilbert schemes for abelian groups we give an explicit description of the G-Hilbert scheme for G equal to a cyclic group of order r, acting on C^3 with weights 1,a,r-a. We describe how the combinatorial properties of the fan of G-Hilbert scheme relates to the Euclidean algorithm for b and r-b, where b is an inverse of a modulo r.

  14. Observations on the Synergistic Interactions of Aqueous Oxidizers and Ultraviolet Radiation for Decontamination Applications

    Science.gov (United States)

    1986-05-20

    alkylbenzene sulfonic acids to carbon dioxide and water using UV irradiation and aqueous hypochlorite. Thus, the synergistic effect of high energy...Perhydroxyl Radicals. A Flash Photolysis Study," Cz.7 J. Cbem. 57, 3017-3022 (1979). M. Nakamura and Y.Ogata, "Photolytic Oxidation of AlkylBenzene Sulfonic ...the low concentration of quinine in the test solution, fluorescence is linear with concentration (Ewing, 1969). Since the pH of 2 x 10-4 quinine

  15. Regulation of Survival by IKKe in Inflammatory Breast Cancer Involves EpCAM

    Science.gov (United States)

    2016-02-01

    responses and normalizes inflammatory cytokines in murine myeloproliferative neoplasms. Blood . 2010;115(25):5232-40. 29. Duncan JS, Whittle MC, Nakamura K...high expression, and blue indicates low expression. (B) Immunoblot of IKBKE and β-actin levels across a panel of TNBC cell lines compared with BT474...combination therapy in an aggressive TNBC PDX model. (A) Spider plot depicting the percentage of change in tumor volume of individual WHIM21 tumors treated

  16. Green tea catechins for well-being and therapy: prospects and opportunities

    OpenAIRE

    Miyoshi N; Pervin M; Suzuki T.; Unno K; Isemura M; Nakamura Y.

    2015-01-01

    Noriyuki Miyoshi,1 Monira Pervin,1 Takuji Suzuki,2 Keiko Unno,3 Mamoru Isemura,1 Yoriyuki Nakamura1 1School of Food and Nutritional Sciences, University of Shizuoka, Yada, Shizuoka, Japan; 2Faculty of Education, Art and Science, Yamagata University, Yamagata, Japan; 3School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka, Japan Abstract: Tea is derived from the leaves and buds of Camellia sinensis (Theaceae) plant, and is consumed worldwide. Green tea was discovered in the...

  17. Formation of PBHs binaries and gravitational waves from their merge

    CERN Document Server

    Eroshenko, Yu N

    2016-01-01

    It was shown by (Nakamura et al. 1997) and (Sasaki et al. 2016) that primordial black holes (PBHs) binaries can form effectively at the cosmological stage of radiation dominance, and the merge of PBHs in pairs can explain the gravitational wave burst GW150914. In this paper, the model is re-examined by considering numerically the evolution of the PBHs orbit. We show that the calculations of (Nakamura et al. 1997) and (Sasaki et al. 2016) have rather high accuracy. However, evolution of the orbit gives additional factors. As a result, the rate of gravitational bursts is about five times higher than (Nakamura et al. 1997) and (Sasaki et al. 2016) predicted. The merge rate of PBHs binaries matches the LIGO data if the PBHs constitute f~10^-4-10^-3 fraction of dark matter. We discuss the effect of inflationary density perturbations which produce additional tidal forces on the binaries. The PBH binaries can form also at the stage of matter domination inside small dark matter halos. Under the influence of dynamic f...

  18. Biological nitrate removal from synthetic wastewater using a fungal consortium in one stage bioreactors

    CSIR Research Space (South Africa)

    Greben, HA

    2007-04-01

    Full Text Available reactive porous media barriers: field trials. Ground Water 33 99-111. SHOUN H and TANIMOTO T (1991) Denitrification by the fungus Fusarium oxysporum and involvement of cytochrome P-450 ibn the respiratory nitrite reduction. J. Biol. Chem. 266 11078..., ZHANG L, SHOUN H, KIMURA K, HAMAMOTO M, NAKASE T (1998) Denitrification by yeasts and occurrence of cytochrome P450nor in Trichosporon cutaneum. FEMS Microbiol. Lett. 168 (1) 105-110. WATSUJI T, TAKAyA N, NAKAMURA A and SHOUN H (2003...

  19. Diagnostic dilemma between intestinal Beh(c)et disease and inflammatory bowel disease with pyoderma gangrenosum

    Institute of Scientific and Technical Information of China (English)

    Cem Evereklioglu

    2006-01-01

    @@ TO THE EDITOR I have read with great interest the very recent article titled"Intestinal Beh(c)et's disease with pyoderma gangrenosum:A case report" of Nakamura T et al that was published in your journal. The authors stated that they presented a very rare case of intestinal Beh(c)et's disease with pyoderma gangrenosum in a 16-year old patient. However, I would like to make some important contributions and suggestions to the presented case and have a few questions to ask the authors.

  20. Departures from the Friedmann-Lemaitre-Robertston-Walker Cosmological Model in an Inhomogeneous Universe: A Numerical Examination.

    Science.gov (United States)

    Giblin, John T; Mertens, James B; Starkman, Glenn D

    2016-06-24

    While the use of numerical general relativity for modeling astrophysical phenomena and compact objects is commonplace, the application to cosmological scenarios is only just beginning. Here, we examine the expansion of a spacetime using the Baumgarte-Shapiro-Shibata-Nakamura formalism of numerical relativity in synchronous gauge. This work represents the first numerical cosmological study that is fully relativistic, nonlinear, and without symmetry. The universe that emerges exhibits an average Friedmann-Lemaître-Robertson-Walker (FLRW) behavior; however, this universe also exhibits locally inhomogeneous expansion beyond that expected in linear perturbation theory around a FLRW background.

  1. Focused Ion Beam Fabrication of Graded Channel Field Effect Transistors (FETs) in GaAs and Si

    Science.gov (United States)

    1988-11-21

    Appl. Phys. 22, L444 (1983). (1981). "A. Wagner and T. M. Hall, J. Vac. Sci. Technol. 16, 1871 (1979). 𔃼T. Shiokawa , P. H. Kim, K. Toyoda. and S...Hwang, R. Bliat, M. Koza, H. W. ’T. Shiokawa , P. H. Kim, K. Toyoda, S. Nama, K. Gamo, R. Aihara. and Yoon, and P. Mei, AppI. Phys. Lett. 49, 701 (1986...Vac. Sci. Technol. B 3,67 (1985). ’K. Nakamura, T. Nozaki. T. Shiokawa . K. Toyoda. and S. Namba, Jpn. ŚY. Ochiai, K. Shihoyama. T. Shiokawa , K

  2. Including gauge symmetry in the localization mechanism of massive vector fields

    CERN Document Server

    Guerrero, Rommel

    2013-01-01

    On the four-dimensional sector of an AdS$_5$ warped geometry the standard electromagnetic interaction can be simulated by massive vector fields via the Ghoroku - Nakamura localization mechanism. We incorporate gauge symmetry to this theory by finding the required interaction terms between the vector bosons and the gravitational field of the scenario. The four-dimensional effective theory defined by a Maxwell term and a tower of Stueckelberg fields is obtained after expanding the vector fields on a massive eigenstates basis where the zero mode is uncoupled from the rest of the spectrum. The corrections generated by the massive gauge fields set to the electrostatic potential are also calculated.

  3. Kawasaki Shock Syndrome in a 12-Year-Old Girl Mimicking Septic Shock

    Directory of Open Access Journals (Sweden)

    Vindika Prasad Sinhabahu

    2016-01-01

    Full Text Available Kawasaki disease is diagnosed when fever lasts for more than 5 days with the presence of four out of five of the following clinical features: bilateral conjunctival congestion, changes in the lips and oral cavity, polymorphous exanthem, changes in peripheral extremities, and acute nonpurulent cervical lymphadenopathy (Nakamura et al., 2012. The average age of onset is 2 years and 90% of patients are below 5 years of age. Boys are more affected than girls (Cox and Sallis, 2009. This case report describes an adolescent female who was initially managed as having septic shock and subsequently found to have Kawasaki shock syndrome.

  4. The geometry of the light-cone cell decomposition of moduli space

    Energy Technology Data Exchange (ETDEWEB)

    Garner, David, E-mail: d.p.r.garner@qmul.ac.uk; Ramgoolam, Sanjaye, E-mail: s.ramgoolam@qmul.ac.uk [Centre for Research in String Theory, School of Physics and Astronomy, Queen Mary University of London, Mile End Road, London E1 4NS (United Kingdom)

    2015-11-15

    The moduli space of Riemann surfaces with at least two punctures can be decomposed into a cell complex by using a particular family of ribbon graphs called Nakamura graphs. We distinguish the moduli space with all punctures labelled from that with a single labelled puncture. In both cases, we describe a cell decomposition where the cells are parametrised by graphs or equivalence classes of finite sequences (tuples) of permutations. Each cell is a convex polytope defined by a system of linear equations and inequalities relating light-cone string parameters, quotiented by the automorphism group of the graph. We give explicit examples of the cell decomposition at low genus with few punctures.

  5. Evaluating a Novel Sleep-Focused Mind-body Rehabilitative Program for Veterans. Veterans with mTBI and Other Polytrauma Symptoms: An RCT Study

    Science.gov (United States)

    2013-09-01

    Veterans with mTBI and other “ polytrauma ” symptoms: An RCT study PRINCIPAL INVESTIGATOR: Yoshio Nakamura, Ph.D. CONTRACTING...Veterans with mTBI and other “ polytrauma ” symptoms: An RCT study 5a. CONTRACT NUMBER W81XWH-12-1-0385 5b. GRANT NUMBER W81XWH-12-1-0385...DoD HRPO and started planning study logistics and refined them by meeting with the Polytrauma clinic to inform their personnel about the study and

  6. CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia

    Digital Repository Service at National Institute of Oceanography (India)

    Ravindran, C.; Cheng, Y.-C.; Liang, S.-M.

    -1 gene expression in transgenic mice. J. Leukocyte Biol. 75 (2004) 460–466. [4]. Kuo, C.C., Kuo,C.W., Liang, C.M and Liang, S.M. A transcriptomic and proteomic analysis of the effect of CpG-ODN on human THP-1 monocytic leukemia cells. Proteomics...]. Rollins, B. J. Chemokines. Blood, 190 (1997) 909-928. [26]. Ono, S.J., Nakamura, T., Miyazaki, D., Ohbayashi, M., Dawson, M and Toda, M.. Chemokines: roles in leukocyte development, trafficking, and effector function. J Allergy Clin Immunol., 111...

  7. Hyperbolicity of Scalar Tensor Theories of Gravity

    CERN Document Server

    Salgado, Marcelo; Alcubierre, Miguel; Núñez, Dario

    2008-01-01

    Two first order strongly hyperbolic formulations of scalar tensor theories of gravity (STT) allowing non-minimal couplings (Jordan frame) are presented along the lines of the 3+1 decomposition of spacetime. One is based on the Bona-Masso formulation while the other one employs a conformal decomposition similar to that of Baumgarte-Shapiro-Shibata-Nakamura. A modified Bona-Masso slicing condition adapted to the STT is proposed for the analysis. This study confirms that STT posses a well posed Cauchy problem even when formulated in the Jordan frame.

  8. Second-order Gauge-invariant Cosmological Perturbation Theory 2; Perturbations of energy momentum tensors and equations of motion for matter fields

    CERN Document Server

    Nakamura, Kouji

    2008-01-01

    Some formulae for the perturbations of the matter fields are summarized within the framework of the second-order gauge-invariant cosmological perturbation theory in a four dimensional homogeneous isotropic universe, which is developed in the papers [K. Nakamura, Prog. Theor. Phys. {\\bf 117} (2005), 17.]. We derive the formulae for the perturbations of the energy momentum tensors and equations of motion in the cases of a perfect fluid, an imperfect fluid, and a signle scalar field, and show that all equations are derived in terms of gauge-invariant variables without any gauge fixing.

  9. III-Nitride, SiC and Diamond Materials for Electronic Devices. Symposium Held April 8-12 1996, San Francisco, California, U.S.A. Volume 423.

    Science.gov (United States)

    1996-12-01

    Baliga, IEEE Electron Device Lett. 10, 455 (1989). 3. M. Bhatnagar and B.J. Baliga, IEEE Trans. Electron Devices, 19 4. T.P. Chow and R. Tyagi, IEEE...Nakamura et al. of Nichia Chemical have achieved InGaN multi-quantum well (MQW) structure blue/violet lasing under pulsed current injection [3]. Although...Among these, p-type ohmic contact is considered one of the most important. According to the I-V characteristics of the Nichia laser, the turn-on

  10. Stemcell Information: SKIP000278 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available man bFGF ... Negative ... Yes ... Natsumi Shimizu 清水 なつみ RIKEN BioResource Center 理化学研究所バイオリソースセンタ...ー RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Available--Avai...lable--Available RIKEN BioResource Center--Makoto Yazaki(Nagoya City University)--iPS Academia Japan,Inc. 理化学

  11. Stemcell Information: SKIP000655 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  12. Stemcell Information: SKIP000653 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information O...nly RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0774.

  13. Stemcell Information: SKIP000657 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  14. Stemcell Information: SKIP000645 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available kaline phosphatase staining and immunocytochemistry ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information On...ly RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0774.2

  15. Stemcell Information: SKIP000661 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  16. Stemcell Information: SKIP000656 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  17. Stemcell Information: SKIP000649 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Fujioka 藤岡 剛 RIKEN BioResource Center 理化学研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Na...kamura 中村 幸夫 Information Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 209

  18. Stemcell Information: SKIP000651 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ujioka 藤岡 剛 RIKEN BioResource Center 理化学研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Naka...mura 中村 幸夫 Information Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973

  19. Stemcell Information: SKIP000220 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available 0.1mM 2-Mercaptoethanol+5ng/mL human bFGF ... Yes 46XX(18), 47XX+X(2) ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BRC 理化学...研究所バイオリソースセンター RIKEN BRC 理化学研究所バイオリソースセンター Yukio Nakamura 中村幸夫 Available RIKEN BRC 理化学研究所バイオリ

  20. Stemcell Information: SKIP000660 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  1. Stemcell Information: SKIP000658 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  2. Stemcell Information: SKIP000647 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available staining and immunocytochemistry ... Yes Teratoma formation ... Yes ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Informat...ion Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-

  3. Stemcell Information: SKIP000659 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  4. Stemcell Information: SKIP000641 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Alkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Informati...on Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0

  5. Stemcell Information: SKIP000643 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available kaline phosphatase staining and immunocytochemistry ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information On...ly RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0774.2

  6. Stemcell Information: SKIP000638 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Alkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Informati...on Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0

  7. Stemcell Information: SKIP000654 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available ujioka 藤岡 剛 RIKEN BioResource Center 理化学研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Naka...mura 中村 幸夫 Information Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973

  8. Stemcell Information: SKIP000652 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information O...nly RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0774.

  9. Stemcell Information: SKIP000642 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available kaline phosphatase staining and immunocytochemistry ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information On...ly RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0774.2

  10. Stemcell Information: SKIP000222 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available +5ng/mL human bFGF ... Yes 46XY(20) ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BRC 理化学研究所バイオリソースセンター RIKEN BRC 理化学...研究所バイオリソースセンター Yukio Nakamura 中村幸夫 Available RIKEN BRC 理化学研究所バイオリソースセンター http://www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=HPS0029&type=1 ...

  11. Stemcell Information: SKIP000640 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Alkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Informatio...n Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-07

  12. Stemcell Information: SKIP000637 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available Alkaline phosphatase staining and immunocytochemistry ... Yes ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Informati...on Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-0

  13. Stemcell Information: SKIP000650 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available lkaline phosphatase staining and immunocytochemistry ... No ... Yes ... Tsuyoshi Fujioka 藤岡 剛 RIKEN BioResource Center 理化学...研究所バイオリソースセンター RIKEN BioResource Center 理化学研究所バイオリソースセンター Yukio Nakamura 中村 幸夫 Information... Only RIKEN BioResource Center 理化学研究所バイオリソースセンター ... 20973836 10.1111/j.1749-077

  14. Enzyme treatment to decrease solids and improve digestion of primary sewage sludge

    CSIR Research Space (South Africa)

    Roman, HJ

    2006-05-01

    Full Text Available and Tunnacliffe, 2003), application of bacteriophages (Withey et al., 2005) and increasing the energetic requirements of cell maintenance (Hamoda and Al-attar, 1995). These methods all address the reduction of the biomass component of the DS. However..., Stephenson T (2005). Bacteriophages - potential for application in wastewater treatment processes. Sci. Tot. Environ. 339(1-3): 1-18. Yasui H, Nakamura K, Sakuma S, Iwasaki M and Sakai Y (1996). A full- scale operation of a novel activated sludge process...

  15. REST IN PEACE

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    Keiko Nakamura, 73 and a mem- ber of a Japanese war orphans' delegation, kneels down at a cemetery for adoptive Chinese parents in Fangzheng County, northeast China's Heilongjiang Province, on July 13 dudng a visit to China. More than 4,000 Japanese chil- dren were abandoned by their birth parents during the retreat at the end of World War II in 1945. These orphans were taken in and raised by residents in northeast China, which Japan illegally occupied for over a decade. Most of them relocated to Japan after the two neighbors normalized relations in 1972.

  16. Comparison of clinical features between primary and drug-induced sleep-related eating disorder

    OpenAIRE

    Komada Y; Takaesu Y; Matsui K.; Nakamura M; Nishida S; Kanno M; Usui A; Inoue Y

    2016-01-01

    Yoko Komada,1 Yoshikazu Takaesu,2 Kentaro Matsui,3 Masaki Nakamura,3 Shingo Nishida,3 Meri Kanno,3,† Akira Usui,3 Yuichi Inoue1,3 1Department of Somnology, 2Department of Psychiatry, Tokyo Medical University, 3Japan Somnology Center, Institute of Neuropsychiatry, Tokyo, Japan †Meri Kanno passed away on March 1, 2016 Purpose: The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED). Patients and me...

  17. Investigation of deep levels in bulk GaN

    OpenAIRE

    2014-01-01

    The first gallium nitride (GaN) crystal was grown by hydride vapor phase epitaxy in 1969 by Maruska and Tietjen and since then, there has been an intensive development of the field, especially after the ground breaking discoveries concerning growth and p-type doping of GaN done by the 2014 year Nobel Laureates in Physics, Isamu Akasaki, Hiroshi Amano and Shuji Nakamura. GaN and its alloys with In and Al belong to a semiconductor group which is referred as the III-nitrides. It has outstanding ...

  18. Geometrical design and measurement of light-emitting diode for lighting

    OpenAIRE

    Cheung, Wing-shing; 章永聖

    2015-01-01

    Year 2014 is a milestone in the history of LEDs industry. Isamu Akasaki, Hiroshi Amano and Shuji Nakamura were awarded the Nobel Prize in Physics 2014 for their contribution in the application of “bright and energy-saving white light sources” with invention of efficient blue indium gallium nitrate (InGaN) light-emitting diodes (LED) [1]. This can be treated as an admission of the impotence of LED lighting in the modern human civilization. Although the LED- related technologies had been we...

  19. High-Tc spin superfluidity in antiferromagnets.

    Science.gov (United States)

    Bunkov, Yu M; Alakshin, E M; Gazizulin, R R; Klochkov, A V; Kuzmin, V V; L'vov, V S; Tagirov, M S

    2012-04-27

    We report the observation of the unusual behavior of induction decay signals in antiferromagnetic monocrystals with Suhl-Nakamura interactions. The signals show the formation of the Bose-Einstein condensation (BEC) of magnons and the existence of spin supercurrent, in complete analogy with the spin superfluidity in the superfluid (3)He and the atomic BEC of quantum gases. In the experiments described here, the temperature of the magnon BEC is a thousand times larger than in the superfluid (3)He. It opens a possibility to apply the spin supercurrent for various magnetic spintronics applications.

  20. Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces

    OpenAIRE

    Yang X; Zhu L; Tada S; Zhou D.; Kitajima T; Isoshima T; Yoshida Y; Nakamura M; Yan W.; Ito Y.

    2014-01-01

    Xi Yang,1,2 Liping Zhu,1 Seiichi Tada,1 Di Zhou,3 Takashi Kitajima,1 Takashi Isoshima,1 Yasuhiro Yoshida,1,4 Mariko Nakamura,1,5 Weiqun Yan,2 Yoshihiro Ito1,3 1Nano Medical Engineering Laboratory, RIKEN, Saitama, Japan; 2School of Pharmaceutical Sciences, Jilin University, Jilin, People’s Republic of China; 3Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, Saitama, 4Department of Biomaterials and Bioengineering, Graduate School of Dental Med...

  1. Kultur Kelas Menengah dan Kelahiran ICMI

    Directory of Open Access Journals (Sweden)

    Saiful Mujani

    2014-05-01

    Full Text Available Robert W. Hefner and Mitsuo Nakamura argue that the establishment of the Ikatan Cendikiawan Muslim se-Indonesia (ICMI, or the Muslim Intellectual Society of Indonesia, is a manifestation of the rising Muslim middle class that the cultural foundation of the Muslim middle class and the ICMI is 'renewal Islam' or Islamic neomodernism, which stresses the modern spirit: tolerant, pluralist, moderate, democratic, etc.Copyright (c 2014 by SDI. All right reserved.DOI: 10.15408/sdi.v1i1.872

  2. 潜孔の設置位置がアユの遡上特性に与える影響

    OpenAIRE

    鬼束, 幸樹; 秋山, 壽一郎; 松田, 孝一郎; 寺島, 大輔

    2011-01-01

    Nakamura pointed out that the notch should be placed on one-side compared with alternate to shorten the amount of staying time of fish in a pool. However, there is little information on the suitable orifice location for shorten the amount of staying time of fish in a pool. In this study, orifice location in a pooland-weir fishway is changed alternate or one-side. Behaviors of ayu, Plecoglossus altivelis altivelis, were obtained with the aid of two sets of digital video cameras. It was found t...

  3. Identificación del agente causal de la antracnosis de Sansevieria spp. en Costa Rica

    OpenAIRE

    Pérez León, Gerardo; Chavarría Pérez, Lourdes; Araya Quesada, Julio; Gómez-Alpízar, Luis

    2013-01-01

    Sansevieria spp. (Agavaceae) es una ornamental de follaje originaria de África y Asia. S. trifasciata (St) es la especie con mayor número de cultivares en el mercado de exportación de Costa Rica a Estados Unidos y Holanda. Muestras foliares de S. trifasciata var. “Hahnii” con lesiones circulares y acuosas (algunas alargadas y secas), fueron analizadas. El patógeno recu- perado fue identificado como Colletotrichum sansevieriae Nakamura (CsN) mediante pruebas de patogenicidad, morfología y técn...

  4. Proceedings of the Integrated Ocean Drilling Program Vol. 341: Expedition reports Southern Alaska margin

    Digital Repository Service at National Institute of Oceanography (India)

    Jaeger, J.M.; Gulick, S.P.S.; LeVay, L.J.; Asahi, H.; Bahlburg, H.; Belanger, C.L.; Berbel, G.B.B.; Childress, L.B.; Cowan, E.A.; Drab, L.; Forwick, M.; Fukumura, A.; Ge, S.; Gupta, S.M.; et. al.

    . Ojima, K.D. Ridgway, F. Rodrigues Ribeiro, O.E. Romero, A.L. Slagle, J.S. Stoner, G. St-Onge, I. Suto, M.H. Walczak, and L.L. Worthington2 Chapter contents Abstract . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction...., Gupta, S.M., Kioka, A., Konno, S., März, C.E., Matsuzaki, K.M., McClymont, E.L., Mix, A.C., Moy, C.M., Müller, J., Nakamura, A., Ojima, T., Ridgway, K.D., Rodrigues Ribeiro, F., Romero, O.E., Slagle, A.L.,Stoner, J.S., St-Onge, G., Suto, I., Walczak...

  5. Quantum subgroups of the Haagerup fusion categories

    CERN Document Server

    Grossman, Pinhas

    2011-01-01

    We answer three related questions concerning the Haagerup subfactor and its even parts, the Haagerup fusion categories. Namely we find all simple module categories over each of the Haagerup fusion categories (in other words, we find the `"quantum subgroups" in the sense of Ocneanu), we find all subfactors whose principal even part is one of the Haagerup fusion categories, and we compute the Brauer-Picard groupoid of Morita equivalences of the Haagerup fusion categories. In addition to the two even parts of the Haagerup subfactor, there is exactly one more fusion category which is Morita equivalent to each of them. This third fusion category has six simple objects and the same fusion rules as one of the even parts of the Haagerup subfactor, but has not previously appeared in the literature. We also find the full lattice of intermediate subfactors for every subfactor whose even part is one of these three fusion categories, and we discuss how our results generalize to Izumi subfactors.

  6. Effect of cultivation line and peeling on food composition, taste characteristic, aroma profile, and antioxidant activity of Shiikuwasha (Citrus depressa Hayata) juice.

    Science.gov (United States)

    Asikin, Yonathan; Fukunaga, Hibiki; Yamano, Yoshimasa; Hou, De-Xing; Maeda, Goki; Wada, Koji

    2014-09-01

    Shiikuwasha (Citrus depressa Hayata) juice from four main cultivation lines subjected to two peeling practices (with or without peeling) were discriminated in terms of quality attributes, represented by sugar and organic acid composition, taste characteristic, aroma profile, and antioxidant activity. Shiikuwasha juice from these lines had diverse food compositions; 'Izumi kugani' juice had lower acidity but contained more ascorbic acid than that of other cultivation lines. The composition of volatile aroma components was influenced by fruit cultivation line, whereas its content was affected by peeling process (20.26-53.73 mg L(-1) in whole juice versus 0.82-1.58 mg L(-1) in flesh juice). Peeling also caused Shiikuwasha juice to be less astringent and acidic bitter and to lose its antioxidant activity. Moreover, the total phenolic and ascorbic acid content of Shiikuwasha juice positively influenced its antioxidant activity. Each fruit cultivation line had a distinct food composition, taste characteristic, and aroma profile. Peeling in Shiikuwasha juice production might reduce aftertaste, and thus might improve its palatability. Comprehensive information on the effect of cultivation line and peeling on quality attributes will be useful for Shiikuwasha juice production, and can be applied to juice production of similar small citrus fruits. © 2014 Society of Chemical Industry.

  7. Wilson′s disease masquerading as nonalcoholic steatohepatitis

    Directory of Open Access Journals (Sweden)

    Sabina Mahmood

    2009-01-01

    Full Text Available Background : Wilson′s disease is one of the most common hereditary causes of unclear hepatopathy. Patient & Method: A 34-year old male patient with a history of hyperlipidemia was admitted with symptoms of abdominal pain and slight hematuria. Abnormal liver function tests, ultrasound reports and liver biopsy were suggestive of nonalcoholic steatohepatitis (NASH. The patient received preliminary treatment for NASH. However, on subsequent follow-up, NASH remained unresolved and liver histology showed fibrosis progression from fibrosis stage 1 to stage 3. Results: Biochemical tests revealed that the levels of serum ceruloplasmin were decreased (7mg/dl while the urinary excretion of copper was found to be increased (174.2 μg/day. Wilson′s disease was confirmed by diagnostic mutation analysis involving Direct Sequencing. Heterogeneity in the patient′s ATP7B gene confirmed Wilson′s disease. Administration of D-penicillamine resulted in a decrease in fat deposition in the liver and no further progression in fibrosis after 10 months. Conclusion: Adult patient presenting NASH as first symptoms need to be examined for Wilson′s disease and other metabolic conditions affecting the liver, prior to initiation of treatment. ( Mahmood S, Inada N, Izumi A, Kawanaka M, Kobashi H, Yamada G. Wilson′s disease masquerading as nonalcoholic steatohepatitis.

  8. Successful management of aortic thrombi resulting in spinal cord infarction in a patient with antiphospholipid antibody syndrome and acute cholecystitis

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    Izumi M

    2011-12-01

    Full Text Available Manabu Izumi, Shoko Teraoka, Keisuke Yamashita, Kenji Matsumoto, Tomohiro Muronoi, Yoshimitsu Izawa, Chikara Yonekawa, Masaki Ano, Masayuki SuzukawaDepartment of Emergency and Critical Care Medicine, Jichi Medical University, Tochigi, JapanAbstract: A 74-year-old man with coronary artery disease was suffering from acute nonobstructive cholecystitis and was admitted to a nearby hospital. Dual antiplatelet (aspirin and ticlopidine therapy was discontinued before preparation for surgical resection of the gall bladder. During his time in hospital he was aware of lumbar pain and weakness in both legs. He was transferred to our hospital for further evaluation and therapy. Diffuse intra-aortic thrombi were revealed by computed tomography with contrast media, and magnetic resonance imaging showed spinal cord infarction. However, computed tomography scans of the descending aorta obtained 4 months before admission exhibited no signs of atherosclerotic plaques or intra-aortic thrombi. Laboratory data suggest that antiphospholipid antibody syndrome might have caused these acute multiple intra-arterial thrombi. By restarting dual antiplatelet therapy and increasing the dose of heparin (from 10,000 IU/day to 15,000 IU/day we successfully managed the patient's clinical condition and symptoms. It is important to understand that stopping antiplatelet therapy may rapidly grow thrombi in patients with a hypercoagulative state.Keywords: intra-aortic thrombus, antiphospholipid antibody syndrome, spinal cord infarction

  9. A case of iatrogenic pneumothorax in which chest tube placement could be avoided by intraoperative evaluation with transthoracic ultrasonography

    Directory of Open Access Journals (Sweden)

    Sato I

    2017-07-01

    Full Text Available Izumi Sato, Hirotsugu Kanda, Megumi Kanao-Kanda, Atsushi Kurosawa, Takayuki Kunisawa Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Asahikawa, Hokkaido, Japan Abstract: We report a case of iatrogenic pneumothorax in which chest tube placement was avoided by continuous intraoperative evaluation with transthoracic ultrasonography. A 53-year-old man had undergone a subsegmentectomy. While attempting to place a central venous catheter in the right internal jugular vein after the induction of anesthesia, we identified gas absorption during the puncture and suspected a pneumothorax. Chest X-ray revealed an ~5-mm collapse of the right lung apex. Tension pneumothorax was a concern during surgery because of the long-term positive pressure ventilation, but we decided to start the operation without preventative chest tube placement. During the operation, we regularly observed the midclavicular line of the second intercostal space using ultrasound. The operation was completed uneventfully. In this case, we effectively utilized ultrasound and avoided preventive chest tube placement and the associated complications. Transthoracic ultrasonography could be performed easily and continuously during surgery and was effective for evaluating the progression of an intraoperative pneumothorax. Keywords: transthoracic ultrasonography, iatrogenic pneumothorax, central venous catheterization

  10. Development of fuel alcohol technology. Development of flash fermentation method

    Energy Technology Data Exchange (ETDEWEB)

    1985-08-01

    This is an annual report for 1984 on the development of fuel alcohol fermentation technology. (1) Continuous operation (total 6,000 hours) with a compact fermentation unit (1 l/d alcohol production) increased the productivity up to 1.5 times by a flush fermentation for a high density bacillus. (2) Salt resistance of the bacillus stock for flush fermentation was examined for the selection of the stock to be used in the operation of the test plant. (3) Zaimomonus-mobilis stock was utilized to examine the influence of high-density condition of a light-curing resin on the fermentation characteristics. (4) For a high density bacillus to be loaded in a test plant, a condition for the stable storage for more than 3 months was selected. (5) A test plant with 5 kl/d alcohol production was installed at Izumi Alcohol Plant of NEDO. (6) A unit for preparing high density bacillus granules for loading in the test plant was installed at Kinuura Laboratory of NIKKI K.K..

  11. The Noticing Function of Output in Acquisition of Rhetorical Structure of Contrast Paragraphs of Iranian EFL University Students

    Directory of Open Access Journals (Sweden)

    Soleimani, Hassan

    2008-01-01

    Full Text Available This article is an attempt to contribute to the growing body of research investigating the noticing function of output (cf. Swain 1995 in Izumi/Bigelow 2000: 239, and more specifically the use of output-fronted activities that might prompt FL learners to notice their linguistic problems to facilitate their gain of rhetorical structure of contrast paragraphs in English. Three groups of EFL learners participated in the study. Two groups (the experimental group and comparison group 1 were required to initially produce a paragraph (output 1, then they received a model contrast paragraph to underline, and finally they were asked to produce a contrast paragraph (output 2. For the experimental group, the topic to write was a contrast topic; whereas, the comparison group were to write on a non-contrast topic. The third group (the preemptive comparison group 2 received the teacher's deductive instruction and explanation of contrast paragraphs in English followed by an output to produce a contrast-related paragraph. The results indicated considerable effect of output-fronted activities on learners' noticing the targeted structures and forms. In addition, the output-first-then-input activities were found to be much more effective than pre-emptive input activities.

  12. The Linear Span of Projections in AH Algebras and for Inclusions of C*-Algebras

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    Dinh Trung Hoa

    2013-01-01

    Full Text Available In the first part of this paper, we show that an AH algebra A=lim→(Ai,ϕi has the LP property if and only if every element of the centre of Ai belongs to the closure of the linear span of projections in A. As a consequence, a diagonal AH-algebra has the LP property if it has small eigenvalue variation in the sense of Bratteli and Elliott. The second contribution of this paper is that for an inclusion of unital C*-algebras P⊂A with a finite Watatani index, if a faithful conditional expectation E:A→P has the Rokhlin property in the sense of Kodaka et al., then P has the LP property under the condition thatA has the LP property. As an application, let A be a simple unital C*-algebra with the LP property, α an action of a finite group G onto Aut(A. If α has the Rokhlin property in the sense of Izumi, then the fixed point algebra AG and the crossed product algebra A ⋊α G have the LP property. We also point out that there is a symmetry on the CAR algebra such that its fixed point algebra does not have the LP property.

  13. Seismic reflection survey of the Uemachi fault in Osaka Prefecture; Osaka Uemachi danso no hanshaho danseiha tansa

    Energy Technology Data Exchange (ETDEWEB)

    Sugiyama, Y. [Geological Survey of Japan, Tsukuba (Japan); Yoshizawa, M.; Hirooka, S. [Nikko Exploration and Development Co. Ltd., Tokyo (Japan); Yokota, H.; Ito, S. [Hanshin Consultant Co., Osaka (Japan); Hayashi, K.; Aizawa, H.

    1997-05-27

    Reflection survey is conducted using three traverse lines in Sakai City for confirming the presence of a southward stretch of the Uemachi fault underground along the western periphery of the Uemachi terrace, Osaka, and for elucidating its connection to the Sakamoto fault distributed near Izumi. Another reflection survey is conducted in the bed of Kanzaki river, Osaka, for the confirmation of its connection to the Nembutsuji-zan fault in Senri hillock. It is estimated on the basis of boring data that there exists another flexural structure approximately 3km south of the flexural structure whose presence is confirmed by the Sakai second traverse line. Accordingly, possibilities are high that the southward stretch of the Uemachi fault connects to the Sakamoto fault. The confirmation by the Kanzaki river traverse line of the flexural structure again confirms the continuity between the Uemachi fault and Nembutsuji-zan fault. The above-said findings enable an inference that the three faults of Nembutsuji-zan, Uemachi, and Sakamoto constitute a chain of active faults. Furthermore, there exists an active fault to the south of the Sakamoto fault, which zigzags to the south on the right-hand side as far as the south of the Kumeda pond. Accordingly, the Uemachi fault system as a whole spans approximately 43km from the northern end of the Nembutsuji-zan fault as far as the south of the Kumeda pond. 5 refs., 6 figs.

  14. PREFACE: 3rd International Workshop on Materials Analysis and Processing in Magnetic Fields (MAP3)

    Science.gov (United States)

    Sakka, Yoshio; Hirota, Noriyuki; Horii, Shigeru; Ando, Tsutomu

    2009-07-01

    the journal Science and Technology of Advanced Materials. All articles have been refereed by experts in the field. Both of these journals are fully accessible electronically and can be cited and referenced in the usual way. It is our hope that the reader will enjoy and profit from the MAP3 Proceedings. Hitoshi Wada (Kashiwa, Japan) Chair Eric Beaugon (Grenoble, France) Hans J Schneider-Muntau (Tallahassee, USA) Co-chair Advisory Board Shigeo Asai (Nagoya, Japan) Koichi Kitazawa (Tokyo, Japan) Mitsuhiro Motokawa (Sendai, Japan) Shoogo Ueno (Fukuoka, Japan) Robert Tournier (Grenoble, France) Justin Schwartz (Tallahassee, USA) J C Maan (Nijmegen, Netherland) Scientific Committee Yoshifumi Tanimoto (Hiroshima, Japan) Masuhiro Yamaguchi (Yokohama, Japan) Tsunehisa Kimura (Kyoto, Japan) Yoshio Sakka (Tsukuba Japan) Ryoichi Aogaki (Tokyo, Japan) Jyunji Miyakoshi (Hirosaki, Japan) Kazuo Watanabe (Sendai, Japan) James M Valles Jr. (Providence, USA) Joon Pyo Park (Pohang, Korea) Qiang Wang (Shenyang, China) Nicole Pamme (Hull, UK) Sophie Rivoirard (Grenoble, France) P C M Christianen (Nijmegen, Netherland) Local Organizing Committee Isao Yamamoto Masafumi Yamato Shigeru Horii Norihito Sogoshi Masateru Ikehata Noriyuki Hirota Tsutomu Ando Proceedings Editorial Board Yoshio Sakka Noriyuki Hirota Shigeru Horii Tsutomu Ando Conference photograph

  15. Evaluation of peripheral fundus autofluorescence in eyes with wet age-related macular degeneration

    Directory of Open Access Journals (Sweden)

    Suetsugu T

    2016-12-01

    Full Text Available Tetsuyuki Suetsugu,1,2 Aki Kato,1 Munenori Yoshida,1 Tsutomu Yasukawa,1 Akiko Nishiwaki,1,3 Norio Hasegawa,1 Hideaki Usui,1 Yuichiro Ogura1 1Department of Ophthalmology and Visual Science, Nagoya City University Graduate School of Medical Sciences, 2Department of Ophthalmology, General Kamiiida Daiichi Hospital, 3Nishiwaki Eye Clinic, Nagoya, Aichi, Japan Purpose: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF in wet age-related macular degeneration (AMD using wide-field imaging instrument. Patients and methods: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients, polypoidal choroidal vasculopathy (PCV (22 eyes/20 patients, and retinal angiomatous proliferation (RAP (seven eyes/four patients. Two masked ophthalmologists independently graded the images for mottled, granular, and nummular patterns. Main outcome measures were abnormal peripheral FAF frequencies and relative risks by disease subgroups and treatments. Results: Abnormal peripheral FAF patterns were found in 51.5% of wet AMD eyes compared with 18.8% of control eyes (P<0.001. Mottled, granular, and nummular patterns were found in 45.5%, 31.8%, and 16.7%, respectively, of wet AMD eyes. Each disease subgroup (typical AMD, 54.1%; PCV, 36.4%; and RAP, 85.7% showed significantly higher frequencies of peripheral FAF (P<0.001, P=0.03, and P<0.001, respectively than control eyes (18.8%. There were no significant differences (P=0.76 between the frequencies in untreated and treated eyes. Conclusion: Eyes of Japanese wet AMD patients had a higher abnormal FAF prevalence compared with control eyes. Among the three disease subtypes, abnormal patterns were least prevalent in PCV eyes. Keywords: age-related macular degeneration, fundus autofluorescence, polypoidal choroidal vasculopathy, retinal

  16. Tipepidine in adolescent patients with depression: a 4 week, open-label, preliminary study

    Directory of Open Access Journals (Sweden)

    Sasaki T

    2014-05-01

    Full Text Available Tsuyoshi Sasaki,1,2 Kenji Hashimoto,3 Masumi Tachibana,1 Tsutomu Kurata,1 Hiroshi Kimura,2 Hideki Komatsu,2 Masatomo Ishikawa,2 Tadashi Hasegawa,2 Akihiro Shiina,1 Tasuku Hashimoto,2 Nobuhisa Kanahara,4 Tetsuya Shiraishi,2 Masaomi Iyo1–41Department of Child Psychiatry, Chiba University Hospital, 2Department of Psychiatry, Chiba University Graduate School of Medicine, 3Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 4Division of Medical Treatment and Rehabilitation, Chiba University Center for Forensic Mental Health, Inohana, Chiba, JapanDepression in children and adolescents is a common, recurrent, and debilitating condition associated with increased psychosocial, and medical morbidity and mortality.1The global prevalence of depression in children and adolescents is 1%–2% and 3%–8%, respectively.2 Depressive symptoms are also associated with significant functional impairment in school and the work place (often requiring legal interventions,1–5 and an increased risk for substance abuse and suicide.6–9 Clinical guidelines suggest the use of two selective serotonin reuptake inhibitors (SSRI, namely fluoxetine and escitalopram, both of which are effective with generally acceptable safety profiles in the treatment of adolescent depression.10 Additionally, combination treatment with an SSRI and psychotherapy, typically cognitive behavioral therapy (CBT, has shown benefit in this cohort.10 However, caution is warranted since antidepressants therapy in children and adolescents is associated with increased rates of suicidal ideation11–13 and adverse effects, characterized by excessive emotional arousal or behavioral activation.14 These results highlight the need for new therapies in adolescent patients with depression, particularly therapies with fewer side effects.View original paper by Brent and Maalouf.

  17. Presumed toxoplasmic central retinal artery occlusion and multifocal retinitis with perivascular sheathing

    Directory of Open Access Journals (Sweden)

    Arai H

    2014-04-01

    Full Text Available Haruka Arai,1 Tsutomu Sakai,1 Kiichiro Okano,1 Ranko Aoyagi,1 Ayano Imai,2 Hiroshi Takase,2 Manabu Mochizuki,2 Hiroshi Tsuneoka11Department of Ophthalmology, Jikei University School of Medicine, Tokyo, Japan; 2Department of Ophthalmology and Visual Science, Tokyo Medical and Dental University, Tokyo, JapanAbstract: Central retinal artery occlusion (CRAO and multifocal retinitis with perivascular sheathing are rare in ocular toxoplasmosis. We report a case of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. A healthy 83-year-old male developed left panuveitis. Funduscopic examination of the left eye showed a swollen optic disc and sheathing of the retinal artery with a dense vitreous haze and a white retinal lesion. Serum anti-toxoplasma antibodies were positive in a latex agglutination assay. Vitrectomy was performed to improve visualization of the retinal lesions and for examination of causative microorganisms. A postoperative fundus examination revealed CRAO with optic disc involvement and multifocal retinitis with perivascular sheathing. Qualitative multiplex polymerase chain reaction detected the Toxoplasma gondii B1 gene in ocular fluid from both the aqueous and vitreous humor. The presumed diagnosis of ocular toxoplasmosis was made and treatment was started with prednisone and acetylspiramycin with subsequent improvement. Two months later, the patient developed active retinochoroiditis in the left eye. After 6 weeks of anti-toxoplasma therapy, the disease involuted. Retinal vascular occlusions and multifocal retinitis with perivascular sheathing are rare in toxoplasmosis. This is the first case report of toxoplasmic CRAO and multifocal retinitis with perivascular sheathing. The diagnosis of ocular toxoplasmosis should be considered in patients with retinal artery occlusions and multifocal retinitis with perivascular sheathing associated with inflammation.Keywords: ocular toxoplasmosis, toxoplasma retinochoroiditis

  18. Submucosal tunneling techniques: current perspectives

    Directory of Open Access Journals (Sweden)

    Kobara H

    2014-04-01

    Full Text Available Hideki Kobara,1 Hirohito Mori,1 Kazi Rafiq,2 Shintaro Fujihara,1 Noriko Nishiyama,1 Maki Ayaki,1 Tatsuo Yachida,1 Tae Matsunaga,1 Johji Tani,1 Hisaaki Miyoshi,1 Hirohito Yoneyama,1 Asahiro Morishita,1 Makoto Oryu,1 Hisakazu Iwama,3 Tsutomu Masaki1 1Department of Gastroenterology and Neurology, 2Department of Pharmacology, 3Life Science Research Center, Faculty of Medicine, Kagawa University, Miki-cho, Kita-Gun, Kagawa, Japan Abstract: Advances in endoscopic submucosal dissection include a submucosal tunneling technique, involving the introduction of tunnels into the submucosa. These tunnels permit safer offset entry into the peritoneal cavity for natural orifice transluminal endoscopic surgery. Technical advantages include the visual identification of the layers of the gut, blood vessels, and subepithelial tumors. The creation of a mucosal flap that minimizes air and fluid leakage into the extraluminal cavity can enhance the safety and efficacy of surgery. This submucosal tunneling technique was adapted for esophageal myotomy, culminating in its application to patients with achalasia. This method, known as per oral endoscopic myotomy, has opened up the new discipline of submucosal endoscopic surgery. Other clinical applications of the submucosal tunneling technique include its use in the removal of gastrointestinal subepithelial tumors and endomicroscopy for the diagnosis of functional and motility disorders. This review suggests that the submucosal tunneling technique, involving a mucosal safety flap, can have potential values for future endoscopic developments. Keywords: submucosal endoscopy, submucosal tunneling method, natural orifice transluminal endoscopic surgery, peroral endoscopic myotomy, gastrointestinal subepithelial tumor, functional and motility disorders

  19. The characteristics of keratomycosis by Beauveria bassiana and its successful treatment with antimycotic agents

    Directory of Open Access Journals (Sweden)

    Hiroko Sonoyama

    2008-10-01

    Full Text Available Hiroko Sonoyama1, Kaoru Araki-Sasaki1, Shigeyasu Kazama1, Tsutomu Kawasaki1, Hidenao Ideta1, Atsuko Sunada2, Seishi Asari2, Yoshitsugu Inoue3, Kozaburo Hayashi41Ideta Eye Hospital, Kumamoto, Kumamoto, Japan; 2Department of Laboratory for Clinical Investigation, Osaka University Hospital, Suita, Osaka, Japan; 3Division of Ophthalmology and Visual Science, Department of Medicine of Sensory and Motor Organ, Tottori University, Yonago, Tottori, Japan; 4Immunology and Virology Section Lab, Immunology, NEI, NIH, Bethesda, MD, USAAbstract: Clinical findings and treatment of keratomycosis caused by Beauveria bassiana, an entomopathogenic filamentous fungus, are described for an 80-year-old woman, who was referred to the hospital for ocular pain and redness on the 9th day after an ocular injury caused by the frame of her glasses. She had a long history of recurrent diabetic iritis and continuously used topical antibiotics and corticosteroids. At her first visit, a slit-lamp examination indicated a corneal ulcer confined within the superficial stromal layer, along with a slight infiltration and edema. Only a very few inflammatory cells were seen in the anterior chamber. Direct microscopic examination of corneal scrapings revealed septate fungal hyphae with zig-zag rachis and budding that was subsequently identified as B. bassiana by slide culture. Topical voriconazole with miconazole, pimaricin and oral itraconazole were effective and the lesion disappeared leaving only a mild scar at 2 months. The sensitivity of B. bassiana to various antimycotic agents was confirmed by broth microdilution, agar dilution with the Clinical Laboratory Standard Institute standard, and a disk method using topically applied concentrations. B. bassiana, which exhibits a characteristic appearance in smears and causes superficial keratomycosis, is sensitive to voriconazole with miconazole, pimaricin, and itraconazole.Keywords: Beauveria bassiana, keratomycosis, filamentous

  20. Managing refractory Crohn's disease: challenges and solutions

    Directory of Open Access Journals (Sweden)

    Tanida S

    2015-04-01

    Full Text Available Satoshi Tanida, Keiji Ozeki, Tsutomu Mizoshita, Hironobu Tsukamoto, Takahito Katano, Hiromi Kataoka, Takeshi Kamiya, Takashi Joh Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Aichi Prefecture, Japan Abstract: The goals of treatment for active Crohn's disease (CD are to achieve clinical remission and improve quality of life. Conventional therapeutics for moderate-to-severe CD include 5-aminosalicylic acid, corticosteroids, purine analogs, azathioprine, and 6-mercaptopurine. Patients who fail to respond to conventional therapy are treated with tumor necrosis factor (TNF-α inhibitors such as infliximab and adalimumab, but their efficacy is limited due to primary nonresponse or loss of response. It is suggested that this requires switch to another TNF-α inhibitor, a combination therapy with TNF-α blockade plus azathioprine, or granulocyte and monocyte adsorptive apheresis, and that other therapeutic options having different mechanisms of action, such as blockade of inflammatory cytokines or adhesion molecules, are needed. Natalizumab and vedolizumab are neutralizing antibodies directed against integrin a4 and a4ß7, respectively. Ustekinumab is a neutralizing antibody directed against the receptors for interleukin-12 and interleukin-23. Here, we provide an overview of therapeutic treatments that are effective and currently available for CD patients, as well as some that likely will be available in the near future. We also discuss the advantages of managing patients with refractory CD using a combination of TNF-α inhibitors plus azathioprine or intensive monocyte adsorptive apheresis. Keywords: adalimumab, granulocyte and monocyte adsorptive apheresis, combination therapy, complete remission

  1. Site amplification at five locations in San Francisco, California: A comparison of S waves, codas, and microtremors

    Science.gov (United States)

    Seekins, Linda C.; Wennerberg, Leif; Margheriti, L.; Liu, Hsi-Ping

    1996-01-01

    We compare microtremor data to weak-motion 5-wave and coda recordings at sites in San Francisco in order to clarify the range of applicability of microtremor data to ground-motion prediction. We also compare 5-wave results to coda results. For each type of data, we compute spectral ratios of motions from two soil/rock station pairs and from an uphole/downhole pair in the Marina district. We compute horizontal/vertical ratios (Nakamura's method) at a soil site, a rock site, and the surface and borehole instruments. In the station-pair analyses, microtremor data show amplifications at the same fundamental frequency as S waves, but the frequencies of other peaks do not agree. The amplification at frequencies higher than 2 Hz is greater in the microtremor data. Station-pair ratios of coda data generally show spectral peaks occurring at the same frequencies, but with levels varying from one to four times the amplification from S-wave ratios. Nakamura's method of analyzing microtremors agrees better with S-wave station-pair results than the microtremor station-pair method over a limited frequency band that varies from station to station.

  2. The uncertainty of estimating the thickness of soft sediments with the HVSR method: A computational point of view on weak lateral variations

    Science.gov (United States)

    Bignardi, Samuel

    2017-10-01

    The use of the ratio of microtremor spectra, as computed by the Nakamura's technique, was recently proved successful for the evaluating the thickness of sedimentary covers laying over both shallow and deep rocky bedrocks thus enabling bedrock mapping. The experimental success of such application and its experimental uncertainties are today reported in many publications. To map bedrock, two approaches exist. The first is to assume a constant shear wave velocity profile of the sediments. The second, and most preferable, is Ibs-von Seht and Wohlenberg's, based on correlating Nakamura's curves main peak and wells information. In the latter approach, the main sources of uncertainty addressed by authors, despite the lack of formal proof, comprise local deviations of the subsurface from the assumed model. I first discuss the reliability of the simplified constant velocity approach showing its limitations. As a second task, I evaluate the uncertainty of the Ibs-von Seht and Wohlenberg's approach with focus on local subsurface variations. Since the experimental basis is well established, I entirely focus my investigation on numerical simulations to evaluate to what extent local subsurface deviations from the assumed model may affect the outcome of a bedrock mapping survey. Further, the present investigation strategy suggests that modeling and inversion, through the investigation of the parameters space around the reference model, may reveal a very convenient tool when lateral variations are suspected to exist or when the number of available wells is not sufficient to obtain an accurate frequency-depth regression.

  3. Contribution to the study of nuclear resonance in magnetic media (1963); Contribution a l'etude de la resonance nucleaire dans les milieux magnetique (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Hartmann-Boutron, F. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-06-15

    An attempt is made to interpret the results of nuclear magnetic resonance experiments made by various workers on ferro and ferrimagnetic compounds of the iron group. The problems encountered are the following: effects of the dipolar fields and the hyperfine structure anisotropy; signal intensity; frequency pulling due to the Suhl-Nakamura interaction between nuclear spins ; nuclear relaxation and ferrimagnetic resonance in single domain samples of impure YIG; nuclear relaxation in the Bloch walls of insulators. The results of our calculations are generally in good agreement with experiment. (author) [French] On se propose d'interpreter les resultats d'experiences de resonance magnetique nucleaire fates par divers auteurs sur des composes ferro et ferrimagnetiques du groupe du fer. Les problemes abordes sont les suivants: effets des champs dipolaires et de l'anisotropie de structure hyperfine; intensite des signaux; deplacement de frequence du a l'interaction de Suhl-Nakamura entre spins nucleaires; relaxation nucleaire et resonance ferrimagnetique dans les echantillons monodomaines de grenat de fer et d'yttrium impur; relaxation nucleaire dans les parois de Bloch des isolants. Les resultats des calculs sont generalement en bon accord avec l'experience. (auteur)

  4. A numerical comparison of theories of violent relaxation

    CERN Document Server

    Arad, I

    2005-01-01

    Using N-body simulations with a large set of massless test particles we compare the predictions of two theories of violent relaxation, the well known Lynden-Bell theory and the more recent theory by Nakamura. We derive ``weaken'' versions of both theories in which we use the whole equilibrium coarse-grained distribution function as a constraint instead of the total energy constraint. We use these weaken theories to construct expressions for the conditional probability $K_i(\\tau)$ that a test particle initially at the phase-space coordinate $\\tau$ would end-up in the $i$'th macro-cell at equilibrium. We show that the logarithm of the ratio $R_{ij}(\\tau) \\equiv K_i(\\tau)/K_j(\\tau)$ is directly proportional to the initial phase-space density $f_0(\\tau)$ for the Lynden-Bell theory and inversely proportional to $f_0(\\tau)$ for the Nakamura theory. We then measure $R_{ij}(\\tau)$ using a set of N-body simulations of a system undergoing a gravitational collapse to check the validity of the two theories of violent rel...

  5. Population pharmacokinetics of olprinone in healthy male volunteers

    Directory of Open Access Journals (Sweden)

    Kunisawa T

    2014-03-01

    Full Text Available Takayuki Kunisawa,1 Hidefumi Kasai,2 Makoto Suda,2 Manabu Yoshimura,3 Ami Sugawara,3 Yuki Izumi,3 Takafumi Iida,3 Atsushi Kurosawa,3 Hiroshi Iwasaki3 1Surgical Operation Department, Asahikawa Medical University Hospital, Hokkaido, Japan; 2Clinical Study Management Division, Bell Medical Solutions Inc, Tokyo, Japan; 3Department of Anesthesiology and Critical Care Medicine, Asahikawa Medical University, Hokkaido, Japan Background: Olprinone decreases the cardiac preload and/or afterload because of its vasodilatory effect and increases myocardial contractility by inhibiting phosphodiesterase III. Purpose: The objective of this study was to characterize the population pharmacokinetics of olprinone after a single continuous infusion in healthy male volunteers. Methods: We used 500 plasma concentration data points collected from nine healthy male volunteers for the study. The population pharmacokinetic analysis was performed using the nonlinear mixed effect model (NONMEM® software. Results: The time course of plasma concentration of olprinone was best described using a two-compartment model. The final pharmacokinetic parameters were total clearance (7.37 mL/minute/kg, distribution volume of the central compartment (134 mL/kg, intercompartmental clearance (7.75 mL/minute/kg, and distribution volume of the peripheral compartment (275 mL/kg. The interindividual variability in the total clearance was 12.4%, and the residual error variability (exponential and additive were 22.2% and 0.129 (standard deviation. The final pharmacokinetic model was assessed using a bootstrap method and visual predictive check. Conclusion: We developed a population pharmacokinetic model of olprinone in healthy male adults. The bootstrap method and visual predictive check showed that this model was appropriate. Our results might be used to develop the population pharmacokinetic model in patients. Keywords: phosphodiesterase III inhibitor, men, pharmacokinetic model

  6. Detection of parasitizing coccidia and determination of host crane species, sex and genotype by faecal DNA analysis.

    Science.gov (United States)

    Honma, H; Suyama, Y; Nakai, Y

    2011-11-01

    In Japan, the three main crane species are the endangered red-crowned crane (Grus japonensis) inhabiting Hokkaido, the northernmost island of Japan; the vulnerable hooded crane (Grus monacha); and the vulnerable white-naped crane (Grus vipio). Both the hooded and white-naped cranes migrate in winter to Izumi in Kyushu, the southern island of Japan. In this study, we investigated the cranes and their coccidian parasites, through a targeted molecular approach using faecal DNA to develop a noninvasive method for infectious disease research. To determine the origin of noninvasively collected faecal samples, host species were identified by sequencing a region of approximately 470 bp of the mitochondrial 16S ribosomal RNA gene in the faecal DNA. Furthermore, to avoid sample redundancy, individual determination was performed by fragment analysis using microsatellite and sex-linked markers. For microsatellite genotyping, previously reported markers and markers isolated in this study were examined, and seven loci for red-crowned cranes, eight for hooded cranes and six for white-naped cranes displayed polymorphisms. A low error rate was demonstrated by comparing microsatellite data generated from faecal DNA samples with that generated from feather DNA samples, indicating a high reliability. Polymerase chain reaction-based capillary electrophoresis (PCR-CE), employing genetic markers in the second internal transcribed spacer (ITS2) of nuclear ribosomal DNA, was employed to detect crane coccidia. The sensitivity of detection of PCR-CE using faecal DNA was inferior to that with traditional microscopy; however, our results suggest that PCR-CE can depict crane coccidia diversity with higher resolution and it is a useful tool to characterize community composition of coccidia in detail.

  7. Evolution of the Median Tectonic Line fault zone, SW Japan, during exhumation

    Science.gov (United States)

    Shigematsu, Norio; Kametaka, Masao; Inada, Noriyuki; Miyawaki, Masahiro; Miyakawa, Ayumu; Kameda, Jun; Togo, Tetsuhiro; Fujimoto, Koichiro

    2017-01-01

    Like many crustal-scale fault zones, the Median Tectonic Line (MTL) fault zone in Japan preserves fault rocks that formed across a broad range of physical conditions. We examined the architecture of the MTL at a large new outcrop in order to understand fault behaviours under different crustal levels. The MTL here strikes almost E-W, dips to the north, and juxtaposes the Sanbagawa metamorphic rocks to the south against the Izumi Group sediments to the north. The fault core consists mainly of Sanbagawa-derived fault gouges. The fault zone can be divided into several structural units, including two slip zones (upper and lower slip zones), where the lower slip zone is more conspicuous. Crosscutting relationships among structures and kinematics indicate that the fault zone records four stages of deformation. Microstructures and powder X-ray diffraction (XRD) analyses indicate that the four stages of deformation occurred under different temperature conditions. The oldest deformation (stage 1) was widely distributed, and had a top-to-the-east (dextral) sense of slip at deep levels of the seismogenic zone. Deformation with the same sense of slip, then became localised in the lower slip zone (stage 2). Subsequently, the slip direction in the lower slip zone changed to top-to-the-west (sinistral-normal) (stage 3). The final stage of deformation (stage 4) involved top-to-the-north normal faulting along the two slip zones within the shallow crust (near the surface). The widely distributed stage 1 damage zone characterises the deeper part of the seismogenic zone, while the sets of localised principal slip zones and branching faults of stage 4 characterise shallow depths. The fault zone architecture described in this paper leads us to suggest that fault zones display different behaviours at different crustal levels.

  8. Current Developments in Research on the Teaching of Grammar

    Institute of Scientific and Technical Information of China (English)

    Hossein Nassaji; Sandra Fotos

    2006-01-01

    @@ Continued from Issue 61 Textual Enhancement There are a number of studies that have investigated the effects of textual enhancement on drawing the learner's attention to grammar, and the method has been described as the least explicit and the least intrusive method of focus on form (Doughty & Varela, 1998). It involves highlighting certain features of input that might go unnoticed under normal circumstances by typographically manipulating them through boldfacing, italicizing, underlining, or capitalizing. The assumption is that such manipulations enhance the perceptual saliency of the target structures, and this, hence, increases their chance of being noticed. A related technique is the provision of numerous instances of target linguistic forms in the input, called an input flood (Trahey & While, 1993). Again,the assumption is that frequent exposure to target items enhances their saliency and hence results in noticing the forms (Schmidt, 1990; Sharwood Smith, 1993). Whereas studies by Doughty (1991) and Fotos (1994) reported positive results in terms of awareness of target structures and proficiency gains resulting from textually enhanced structures, a study by White (1998) did not show that learners who received textually enhanced input differed significantly in their ability to use the target structure compared with those who did not.White concluded that the method of enhancement may not have been sufficiently explicit to draw the learners' attention to the type of linguistic features that involved L1-L2 contrasts. Similarly, Leow (2001) investigated the effects of textual enhancement on learning Spanish formal imperatives and found no advantage for enhanced text over unenhanced text.Finally, Izumi (2001) compared two types of focus on form strategies, output and visual input enhancement, on the learning of English relativization by adult ESL learners, finding that those who produced output developed more than those merely received input. However, the visual

  9. Spatial Correlation of Deep Moonquakes and Mare Basalts and Implications for Lunar Present-day Mantle Structure, Magmatism and Thermal Evolution

    Science.gov (United States)

    Muirhead, A. C.; Zhong, S.

    2010-12-01

    In order to understand the evolution and interior dynamics of the Moon, it is necessary to understand the petrogenesis of the mare basalts which dominate the nearside surface. Samples and observations from the Apollo program have helped put constraints on the composition and the geological processes of the mare basalts. Geochemical and petrological studies of lunar samples suggest that this magmatism must have originated from a heterogeneous mantle and were mostly emplaced between 3.85 and 3.0 billion years ago although the depth of the source regions of the mare basalts is poorly constrained by petrological experiments with estimated depths ranging from 100 to 500 km [Shearer et al, 2006]. This leads to different hypotheses with shallow and deep physical processes for mare basalt genesis [Zhong et al, 2000 and Wieczorek and Phillips, 2000]. Another important first order observation from the Apollo era is the presence of moonquakes recorded by the Apollo Seismic Network. Significant work has been done to locate the hypocenters of the moonquakes, especially those deemed deep moonquake clusters [e.g., Nakamura, 1982]. The deep moonquakes (DMQs) were found to occur at depths of 700-900 km in about 300 clusters or “nests” mostly on the nearside [Nakamura 2003, 2005]. Understanding the location and cause of the DMQ will help constrain the current state of the mantle, including the presence of heterogeneties. While it remains unresolved whether the nearside distribution of DMQs is due to biasing effects of the nearside distribution of Apollo seismic stations, it has been suggested that most of the DMQ nests tend to occur near mare basalt terrains [Minshull and Goult, 1988]. In this study, we have correlated the presence of mare basalts with the epicenters of ~100 deep moonquake clusters, using recent remote sensing data of FeO as a proxy for mare basalts [e.g.,Lawrence et al, 2000] and newly compiled locations of DMQs clusters [Nakamura, 2005]. Our results show that

  10. Una nueva evaluación de la Plaza de los Peregrinos de Pachacamac: aportes de la primera campaña 2003 del Proyecto Arqueológico Pachacamac

    Directory of Open Access Journals (Sweden)

    2004-01-01

    Full Text Available UNE NOUVELLE EVALUATION DE LA PLACE DES PELERINS DE PACHACAMAC. APPORT DE LA PREMIERE CAMPAGNE 2003 DU PROJET ARCHEOLOGIQUE PACHACAMAC. Entre les mois de juin et août 2003, le Projet Archéologique Pachacamac, co-dirigé par Izumi Shimada, Rafael Segura Llanos et María Rostworowski de Diez Canseco, a mené sa première campagne de terrain dans le cadre d'un programme de recherche à long terme. Ce projet interdisciplinaire et international a comme objectif principal l'étude des fondations sociales et du contexte naturel du celèbre site de Pachacamac. L'un des objectifs spécifiques de nos travaux en 2003 a été de définir la localisation et l'extension des zones résidentielles au cours du temps, ce grâce a un radar de pénétration des sols et à des fouilles de sondage. Dans cet essai, nous présentons les résultats les plus importants de ces interventions sur la Place des Pèlerins, plus précisement un secteur proche de l'Ushnu inca. Parmi les divers niveaux d'occupation Ychsma qui ont été détecté, certains ont plus particulièrement attiré notre attention, car ils sont associés à des épisodes récurrents de vénération de jarres en céramique, chacune insérée dans des constructions d'adobes ou des enceintes en pierres soigneusement élaborées. En termes généraux, il nous paraît que les données obtenues représentent une opportunité nouvelle de reviser nos conceptions actuelles de la zone considérée comme sacrée, à la lumière de 1 la découverte de diverses offrandes, denses et superposées, associées à des structures en canne de joncs et adobes, également superposées mais spatialement differenciées et 2 la manifestation d'une série de changements importants dans la nature de l'utilisation de la zone au cours du temps. Durante los meses de junio a agosto del año 2003, el Proyecto Arqueológico Pachacamac, bajo la co-dirección de Izumi Shimada, Rafael Segura Llanos y María Rostworowski de Diez Canseco

  11. Local finite-amplitude wave activity as an objective diagnostic of midlatitude extreme weather

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Gang; Lu, Jian; Burrows, Alex D.; Leung, Lai-Yung R.

    2015-12-28

    Midlatitude extreme weather events are responsible for a large part of climate related damage, yet our understanding of these extreme events is limited, partly due to the lack of a theoretical basis for midlatitude extreme weather. In this letter, the local finite-amplitude wave activity (LWA) of Huang and Nakamura [2015] is introduced as a diagnostic of the 500-hPa geopotential height (Z500) to characterizing midlatitude weather events. It is found that the LWA climatology and its variability associated with the Arctic Oscillation (AO) agree broadly with the previously reported blocking frequency in literature. There is a strong seasonal and spatial dependence in the trend13 s of LWA in recent decades. While there is no observational evidence for a hemispheric-scale increase in wave amplitude, robust trends in wave activity can be identified at the regional scales, with important implications for regional climate change.

  12. Successful treatment of two cases of urorectal septum malformation sequence with oligohydramnios and severe respiratory failure

    Directory of Open Access Journals (Sweden)

    Sekiguchi K

    2013-03-01

    Full Text Available Kazuhito Sekiguchi, Daijiro Takahashi, Takehiko Hiroma, Tomohiko Nakamura Division of Neonatology, Nagano Children's Hospital, Nagano, Japan Abstract: Urorectal septum malformation sequence can be diagnosed prenatally. We report herein the successful treatment of severe respiratory failure in two patients with urorectal septum malformation sequence and prenatally diagnosed oligohydramnios. The patients showed significant hypoxic deterioration and persistent pulmonary artery hypertension soon after birth. We used high-frequency ventilation (HFO, nitric oxide (NO, and extracorporeal membrane oxygenation (ECMO. The patients were successfully weaned from ECMO and artificial ventilation and discharged to home. Although termination of the pregnancy has often been selected for fetuses with oligohydramnios-related urorectal septum malformation sequence, our results suggest the opportunity for these fetuses to be treated using respiratory supports including HFO, NO, and ECMO after birth. Keywords: urorectal septum malformation sequence, oligohydramnios, pulmonary hypoplasia

  13. Anti-inflammatory effects of hyaluronan in arthritis therapy: Not just for viscosity

    Directory of Open Access Journals (Sweden)

    Kayo Masuko

    2009-04-01

    Full Text Available Kayo Masuko1, Minako Murata2, Kazuo Yudoh2, Tomohiro Kato1, Hiroshi Nakamura31Department of Biochemistry; 2Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki-shi, Kanagawa, Japan; 3Department of Joint Disease and Rheumatism, Nippon Medical School, Bunkyo-ku, Tokyo, JapanAbstract: Hyaluronic acid (HA has been widely used for viscosupplementation of diseased or aged articular joints. However, recent investigations have revealed the active anti-inflammatory or chondroprotective effect of HA, suggesting its potential role in attenuation of joint damage. In particular, interactions between HA and other inflammatory mediators are attracting interest. This review summarizes several aspects of recent investigations of the anti-inflammatory effects of HA in arthritis.Keywords: hyaluronan, inflammation, chondroprotection

  14. Convective Heat Transfer over a Wall Mounted Cube Using Large Eddy Simulation

    Directory of Open Access Journals (Sweden)

    Habibollah Heidarzadeh

    2012-06-01

    Full Text Available Fluid flow and convective heat transfer over wall mounted cube have been studied numerically using Large Eddy Simulation. Surface of wall mounted cube and plane floor has a constant heat flux. Two subgrid scale models were used in this study; Wall-Adapting Eddy viscosity (WALE and Dynamic Smagorinsky (DS. The numerical results were compared with the experimental data of Nakamura et al [2] that showed DS model has better results toward WALE model. Results contain the plots of time averaged normalized streamwise velocity and Reynolds stress in different positions, Temperature contours, local Nusselt number over the surfaces of cube and some characteristics of flow field and heat transfer. The local convective heat transfer from the surfaces of the cube and plate are directly related to the complexity of flow field.

  15. Numerical study of Spherically Symmetric solutions on a Cosmological Dynamical Background using the BSSN Formalism

    CERN Document Server

    Rekier, Jeremy; Fuzfa, Andre

    2014-01-01

    We present a fully relativistic numerical method for the study of cosmological problems in spherical symmetry. This involves using the Baumgarte-Shapiro-Shibata-Nakamura (BSSN) formalism on a dynamical Friedmann-Lema\\^itre-Robertson-Walker (FLRW) background. The regular and smooth numerical solution at the center of coordinates proceeds in a natural way by relying on the Partially Implicit Runge-Kutta (PIRK) algorithm described in Montero and Cordero-Carri\\'on [arXiv:1211.5930]. We generalize the usual radiative outer boundary condition to the case of a dynamical background. We show the stability and convergence properties of the method in the study of pure gauge dynamics on a de Sitter background and present a simple application to cosmology by reproducing the Lema\\^itre-Tolman-Bondi (LTB) solution for the collapse of pressure-less matter.

  16. Boolean approach to dichotomic quantum measurement theories

    Science.gov (United States)

    Nagata, K.; Nakamura, T.; Batle, J.; Abdalla, S.; Farouk, A.

    2017-02-01

    Recently, a new measurement theory based on truth values was proposed by Nagata and Nakamura [Int. J. Theor. Phys. 55, 3616 (2016)], that is, a theory where the results of measurements are either 0 or 1. The standard measurement theory accepts a hidden variable model for a single Pauli observable. Hence, we can introduce a classical probability space for the measurement theory in this particular case. Additionally, we discuss in the present contribution the fact that projective measurement theories (the results of which are either +1 or -1) imply the Bell, Kochen, and Specker (BKS) paradox for a single Pauli observable. To justify our assertion, we present the BKS theorem in almost all the two-dimensional states by using a projective measurement theory. As an example, we present the BKS theorem in two-dimensions with white noise. Our discussion provides new insight into the quantum measurement problem by using this measurement theory based on the truth values.

  17. A case series of pregnancy- and lactation-associated osteoporosis and a review of the literature

    Directory of Open Access Journals (Sweden)

    Nakamura Y

    2015-09-01

    Full Text Available Yukio Nakamura,1,2 Mikio Kamimura,3 Shota Ikegami,1 Keijiro Mukaiyama,4 Masatoshi Komatsu,1 Shigeharu Uchiyama,1 Hiroyuki Kato11Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, 2Department of Orthopaedic Surgery, Showa Inan General Hospital, Komagane, 3Center of Osteoporosis and Spinal Disorders, Kamimura Clinic, Matsumoto, 4Department of Orthopaedic Surgery, Azumi General Hospital, Azumino, JapanAbstract: The syndrome of pregnancy- and lactation-associated osteoporosis is a rare disorder whose precise etiology and treatment are largely unknown. We herein report two such cases occurring in the early postpartum period that led to multiple fragility compression fractures. Combination therapy of vitamin D and vitamin K enabled a marked gradual increase in bone mineral density.Keywords: fracture, vitamin D, vitamin K, bone mineral density

  18. Spin gap and string order parameter in the ferromagnetic spiral staircase heisenberg ladder: a quantum Monte Carlo study.

    Science.gov (United States)

    Brünger, C; Assaad, F F; Capponi, S; Alet, F; Aristov, D N; Kiselev, M N

    2008-01-11

    We consider a spin-1/2 ladder with a ferromagnetic rung coupling J perpendicular and inequivalent chains. This model is obtained by a twist (theta) deformation of the ladder and interpolates between the isotropic ladder (theta=0) and the SU(2) ferromagnetic Kondo necklace model (theta = pi). We show that the ground state in the (theta, J perpendicular) plane has a finite string order parameter characterizing the Haldane phase. Twisting the chain introduces a new energy scale, which we interpret in terms of a Suhl-Nakamura interaction. As a consequence we observe a crossover in the scaling of the spin gap at weak coupling from delta/J parallel proportional, variant J perpendicular/J parallel for theta theta c. Those results are obtained on the basis of large scale quantum Monte Carlo calculations.

  19. Einstein-Yang-Mills solitons towards new degrees of freedom

    CERN Document Server

    Galtsov, D V

    1998-01-01

    A recent progress in obtaining non-spherical and non-static solitons in the four-dimensional Einstein--Yang--Mills (EYM) theory is discussed, and a non-perturbative formulation of the stationary axisymmetric problem is attempted. First a 2D dilaton gravity model is derived for the spherically symmetric time-dependent configurations. Then a similar Euclidean representation is constructed for the stationary axisymmetric non-circular SU(2) EYM system using the (2+1)+1 reduction scheme suggested by Maeda, Sasaki, Nakamura and Miyama. The crucial role in this reduction is played by the extra terms entering the reduced Yang--Mills and Kaluza--Klein two-forms similarly to Chern--Simons terms in the theories with higher rank antisymmetric tensor fields. We also derive a simple 2D action describing static axisymmetric magnetic EYM configurations and discuss a possibility of existence of cylindrical EYM sphalerons.

  20. McKay correspondence

    CERN Document Server

    Reid, M

    1997-01-01

    This is a rough write-up of my lecture at Kinosaki and two lectures at RIMS workshops in Dec 1996, on work in progress that has not yet reached any really worthwhile conclusion, but contains lots of fun calculations. History of Vafa's formula, how the McKay correspondence for finite subgroups of SL(n,C) relates to mirror symmetry. The main aim is to give numerical examples of how the 2 McKay correspondences (1) conjugacy classes of G homology of resolution (2) representations of G cohomology must work, and to restate my 1992 Conjecture as a *tautology*, like cohomology or K-theory of projective space. Another aim is to give an introduction to Nakamura's results on the Hilbert scheme of G-clusters, following his preprints and his many helpful explanations. This is partly based on joint work with Y. Ito, and has benefited from encouragement and invaluable suggestions of S. Mukai.

  1. Measurement Theory Based on the Truth Values Violates Local Realism

    Science.gov (United States)

    Nagata, Koji

    2017-02-01

    We investigate the violation factor of the Bell-Mermin inequality. Until now, we use an assumption that the results of measurement are ±1. In this case, the maximum violation factor is 2( n-1)/2. The quantum predictions by n-partite Greenberger-Horne-Zeilinger (GHZ) state violate the Bell-Mermin inequality by an amount that grows exponentially with n. Recently, a new measurement theory based on the truth values is proposed (Nagata and Nakamura, Int. J. Theor. Phys. 55:3616, 2016). The values of measurement outcome are either +1 or 0. Here we use the new measurement theory. We consider multipartite GHZ state. It turns out that the Bell-Mermin inequality is violated by the amount of 2( n-1)/2. The measurement theory based on the truth values provides the maximum violation of the Bell-Mermin inequality.

  2. Quantum Cryptography Based on the Deutsch-Jozsa Algorithm

    Science.gov (United States)

    Nagata, Koji; Nakamura, Tadao; Farouk, Ahmed

    2017-09-01

    Recently, secure quantum key distribution based on Deutsch's algorithm using the Bell state is reported (Nagata and Nakamura, Int. J. Theor. Phys. doi: 10.1007/s10773-017-3352-4, 2017). Our aim is of extending the result to a multipartite system. In this paper, we propose a highly speedy key distribution protocol. We present sequre quantum key distribution based on a special Deutsch-Jozsa algorithm using Greenberger-Horne-Zeilinger states. Bob has promised to use a function f which is of one of two kinds; either the value of f( x) is constant for all values of x, or else the value of f( x) is balanced, that is, equal to 1 for exactly half of the possible x, and 0 for the other half. Here, we introduce an additional condition to the function when it is balanced. Our quantum key distribution overcomes a classical counterpart by a factor O(2 N ).

  3. Construções aplicativas em Panará

    Directory of Open Access Journals (Sweden)

    Dourado Luciana

    2002-01-01

    Full Text Available O objetivo desse artigo é analisar a incorporação de posposições (Baker 1988 no verbo da língua Panará (família Jê, tronco Macro-Jê para formar construções aplicativas (Nakamura 1997. O foco da análise são as construções com posposições incorporadas, que mantêm uma cópia foneticamente realizada. Esta análise é baseada na proposta de Nunes (1999, 2001, de acordo com a qual a realização fonética do vestígio da posposição incorporada não compromete a linearização da estrutura, porque a posposição e o verbo hospedeiro podem ser analisados como uma palavra no componente fonológico.

  4. Experiment list: DRX020614 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available all cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC)...totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020614.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DR...X020614.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020614.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020614.20.bed http://dbarchive.biosciencedbc.jp/kyu

  5. Experiment list: DRX020616 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ll cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC) ...otalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020616.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DRX...020616.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020616.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020616.20.bed http://dbarchive.biosciencedbc.jp/kyu

  6. Experiment list: DRX020608 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ll cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC) ...otalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020608.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DRX...020608.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020608.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020608.20.bed http://dbarchive.biosciencedbc.jp/kyu

  7. Experiment list: DRX020615 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ll cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC) ...otalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020615.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DRX...020615.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020615.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020615.20.bed http://dbarchive.biosciencedbc.jp/kyu

  8. Experiment list: DRX020607 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ll cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC) ...otalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020607.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DRX...020607.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020607.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020607.20.bed http://dbarchive.biosciencedbc.jp/kyu

  9. Experiment list: DRX020604 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available all cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC)...totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020604.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DR...X020604.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020604.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020604.20.bed http://dbarchive.biosciencedbc.jp/kyu

  10. Experiment list: DRX020610 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available all cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC)...totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020610.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DR...X020610.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020610.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020610.20.bed http://dbarchive.biosciencedbc.jp/kyu

  11. Experiment list: DRX020606 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available all cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC)...totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020606.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DR...X020606.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020606.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020606.20.bed http://dbarchive.biosciencedbc.jp/kyu

  12. Experiment list: DRX020605 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available all cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC)...totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020605.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DR...X020605.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020605.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020605.20.bed http://dbarchive.biosciencedbc.jp/kyu

  13. Experiment list: DRX020612 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available small cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN B...on-totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020612.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05.../DRX020612.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020612.10.bed http://dba...rchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed20/DRX020612.20.bed http://dbar

  14. Experiment list: DRX020613 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ll cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC) ...otalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020613.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DRX...020613.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020613.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020613.20.bed http://dbarchive.biosciencedbc.jp/kyu

  15. Experiment list: DRX020609 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available all cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BRC)...totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020609.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/DR...X020609.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020609.10.bed http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bed20/DRX020609.20.bed http://dbarchive.biosciencedbc.jp/kyu

  16. Experiment list: DRX020611 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available small cell carcinoma cell line:TC-YIK || sample_provider=Yukio Nakamura (RIKEN BR...n-totalRNA-miRNeasy_Mini-v1.0 || rna_od_260_230=1.85 http://dbarchive.biosciencedbc.jp/kyu...shu-u/hg19/eachData/bw/DRX020611.bw http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed05/...DRX020611.05.bed http://dbarchive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed10/DRX020611.10.bed http://dbar...chive.biosciencedbc.jp/kyushu-u/hg19/eachData/bed20/DRX020611.20.bed http://dbarc

  17. Paraneoplastic retinopathy associated with retroperitoneal liposarcoma

    Directory of Open Access Journals (Sweden)

    Mineo Kondo

    2010-03-01

    Full Text Available Mineo Kondo1, Kumiko Mokuno2, Ai Uemura1, Shu Kachi1, Makoto Nakamura1, Atsuya Kondo3, Hiroko Terasaki11Department of Ophthalmology, Nagoya University Graduate School of Medicine, Nagoya, Japan; 2Department of Ophthalmology, 3Department of Urology, Kariya Toyota General Hospital Kariya, JapanAbstract: We report a case of paraneoplastic retinopathy associated with a retroperitoneal liposarcoma. A 42-year-old man was referred to our hospital with complaints of night blindness and blurred vision in the peripheral field. Electroretinograms showed a progressive amplitude reduction in his both eyes. Abdominal magnetic resonance imaging showed a large retroperitoneal mass, and pathologic examination revealed a dedifferentiated liposarcoma. Western blot analysis showed an antiretinal antibody in the serum of our patient, and his serum reacted with the photoreceptors of a bovine retina. To the best of our knowledge, this is the first case of paraneoplastic retinopathy associated with a liposarcoma.Keywords: paraneoplastic retinopathy, retroperitneal liposarcoma, electroretinogram, cancerassociated retinopathy

  18. Modified alkaline elution allows the measurement of intact apurinic sites in mammalian genomic DNA.

    Science.gov (United States)

    Malvy, C; Lefrançois, M; Bertrand, J R; Markovits, J

    2000-08-01

    The presence of apurinic/apyrimidinic (AP) sites in cell genomes is known to be toxic and mutagenic. These lesions are therefore repaired in cells by efficient enzymatic systems. However, a report (Nakamura and Swenberg, Cancer Res. 59 (1999) 2522-2526) indicates an unexpected high rate of endogenous apurinic/apyrimidinic (AP) sites in genomic DNA in mammalian tissues. The technology used does not allow the authors to distinguish between intact AP sites and 3'cleaved AP sites. The corresponding values range between 2 and 4 sites per million of nucleotides in various human and rat tissues. Using a modified alkaline elution method we show here that the stationary level of intact AP sites is about 0.16 per million of nucleotides in leukemic mouse L1210 cells.

  19. SOHO的中日差异比较——日本设计师中村诚宏的深度解读

    Institute of Scientific and Technical Information of China (English)

    陈雅男

    2012-01-01

    <正>潘石屹的SOHO中国在十年前打造了中国SOHO住宅的新风尚,中村诚宏(Nakamura Nobuhiro)是SOHO中国"建外SOHO"项目的负责设计师之一,他以独特的日本SOHO住宅的设计理念为观照,重点突出了"无中心、多层次、混合就是活力"的特点,"把建外SOHO做成开放的,把一条条街穿插到建筑中去,打破了北京胡同和四合院的封闭概念",构筑了中国首个商住合用的建筑群样式。

  20. Total synthesis of the congested propellane alkaloid (-)-acutumine.

    Science.gov (United States)

    Castle, Steven L

    2014-08-01

    The enantioselective total synthesis of (-)-acutumine is described. The synthetic strategy was inspired by the premise that the cyclohexenone ring could be derived from an aromatic precursor. After successful construction of a propellane model system, an initial attempt to prepare the spirocyclic subunit was thwarted by incorrect regioselectivity in a radical cyclization. A second-generation approach involving a radical-polar crossover reaction was successful, and the chemistry developed in the aforementioned model system was then applied to synthesize the natural product. Key reactions included a phenolic oxidation, a diastereoselective ketone allylation utilizing Nakamura's chiral allylzinc reagent, an anionic oxy-Cope rearrangement, an acid-promoted cyclization of a secondary amine onto an α,β-unsaturated ketal, and a regioselective methyl enol etherification of a 1,3-diketone.

  1. Attack on Digital Multi-Signature Scheme Based on Elliptic Curve Cryptosystem

    Institute of Scientific and Technical Information of China (English)

    Duo Liu; Ping Luo; Yi-Qi Dai

    2007-01-01

    The concept of multisignature, in which multiple signers can cooperate to sign the same message and any verifier can verify the validity of the multi-signature, was first introduced by Itakura and Nakamura.Several multisignature schemes have been proposed since.Chen et al.proposed a new digital multi-signature scheme based on the elliptic curve cryptosystem recently.In this paper, we show that their scheme is insecure, for it is vulnerable to the so-called active attacks, such as the substitution of a "false" public key to a "true" one in a key directory or during transmission.And then the attacker can sign a legal signature which other users have signed and forge a signature himself which can be accepted by the verifier.

  2. Strongly correlated impurity band superconductivity in diamond: X-ray spectroscopic evidence

    Directory of Open Access Journals (Sweden)

    G. Baskaran

    2006-01-01

    Full Text Available In a recent X-ray absorption study in boron doped diamond, Nakamura et al. have seen a well isolated narrow boron impurity band in non-superconducting samples and an additional narrow band at the chemical potential in a superconducting sample. We interpret the beautiful spectra as evidence for upper Hubbard band of a Mott insulating impurity band and an additional metallic 'mid-gap band' of a conducting 'self-doped' Mott insulator. This supports the basic framework of a recent theory of the present author of strongly correlated impurity band superconductivity (impurity band resonating valence bond, IBRVB theory in a template of a wide-gap insulator, with no direct involvement of valence band states.

  3. INCLUDING GAUGE SYMMETRY IN THE LOCALIZATION MECHANISM OF MASSIVE VECTOR FIELDS // INCLUYENDO SIMETRÍA DE CALIBRE EN EL MECANISMO DE LOCALIZACIÓN DE CAMPOS VECTORIALES MASIVOS

    Directory of Open Access Journals (Sweden)

    Rommel Guerrero

    2013-12-01

    Full Text Available On the four-dimensional sector of an AdS5 warped geometry the standard electromagnetic interaction can be simulated by massive vector fields via the Ghoroku - Nakamura localization mechanism. We incorporate gauge symmetry to this theory by finding the required interaction terms between the vector bosons and the gravitational field of the scenario. The fourdimensional effective theory defined by a Maxwell term and a tower of Stueckelberg fields is obtained after expanding the vector fields on a massive eigenstates basis where the zero mode is uncoupled from the rest of the spectrum. The corrections generated by the massive gauge fields set to the electrostatic potential are also calculated. Keywords: Brane worlds, vector fields localization, electrostatic potential. // RESUMEN La interacción electromagnética sobre el sector cuatro-dimensional de una geometría AdS5 warped puede ser simulada por campos vectoriales masivos a través del mecanismo de localización de Ghoroku - Nakamura. En este trabajo incorporamos simetría de calibre a esta teoría hallando los términos de interacción requeridos entre los bosones vectoriales y el campo gravitacional del escenario. Se presenta la teoría efectiva cuatro-dimensional obtenida luego de expandir los campos vectoriales en una base de autofunciones masiva, donde el modo cero se encuentra desacoplado del resto del espectro y en correspondencia con un término de Maxwell mientras que los estados masivos generan una torre de campos de Stueckelberg. Las correcciones al potencial electrostático inducidas por el espectro de campos masivo también son determinadas.

  4. List of participants at SIDE IV meeting, Tokyo, 27 November--1 December 2000

    Science.gov (United States)

    2001-12-01

    Mark J Ablowitz, Vsevolod Adler, Mark Alber, Said Belmehdi, Marco Boiti, Claude Brezinski, R Bullough, Y M Chiang, Theodore Chihara, Peter A Clarkson, Robert Conte, Adam Doliwa, Vladimir Dorodnitsyn, Mitsuaki Eguchi, Claire Gilson, Basil Grammaticos, Valeri Gromak, Rod Halburd, Koji Hasegawa, Jarmo Hietarinta, Ryogo Hirota, Xing Biao Hu, M Idzumi, J Inoguchi, Hiroya Ishikara, Mourad Ismail, Shin Isojima, Kenichi Ito, Yoshiaki Itoh, Masashi Iwasaki, Klara Janglajew, Michio Jimbo, Nalini Joshi, Kenji Kajiwara, Saburo Kakei, Masaru Kamata, Satoshi Kamei, Rinat Kashaev, Shingo Kawai, Taeko Kimijima, K Kimura, Anatol Kirillov, Koichi Kondo, Boris Konopelchenko, Martin Kruskal, Atsuo Kuniba, Wataru Kunishima, Franklin Lambert, Serguei Leble, Decio Levi, Shigeru Maeda, Manuel Manas, Ken-Ichi Maruno, Tetsu Masuda, J Matsukidaira, Atsushi Matsumiya, Shigeki Matsutani, Yukitaka Minesaki, Mikio Murata, Micheline Musette, Atsushi Nagai, Katsuya Nakagawa, Atsushi Nakamula, Akira Nakamura, Yoshimasa Nakamura, Frank Nijhoff, J J C Nimmo, Katsuhiro Nishinari, Michitomo Nishizawa, A Nobe, Masatoshi Noumi, Yaeko Ohsaki, Yasuhiro Ohta, Kazuo Okamoto, Alexandre Orlov, Naoki Osada, Flora Pempinelli, Spiro Pyrlis, Reinout Quispel, Orlando Ragnisco, Alfred Ramani, Jean-Pierre Ramis, Andreas Ruffing, Simon Ruijsenaars, Satoru Saito, Noriko Saitoh, Hidetaka Sakai, Paulo Santini, Narimasa Sasa, Ryu Sasaki, Yoshikatsu Sasaki, Junkichi Satsuma, Sergei Sergeev, Nobuhiko Shinzawa, Evgueni Sklyanin, Juris Suris, Norio Suzuki, Yukiko Tagami, Katsuaki Takahashi, Daisuke Takahashi, Tomoyuki Takenawa, Yoshiro Takeyama, K M Tamizhmani, T Tamizhmani, Kouichi Toda, Morikatsu Toda, Tetsuji Tokihiro, Takayuki Tsuchida, Yohei Tsuchiya, Teruhisa Tsuda, Satoru Tsujimoto, Walter Van Assche, Claude Viallet, Luc Vinet, Shinsuke Watanabe, Yoshihida Watanabe, Ralph Willox, Pavel Winternitz, Yasuhiko Yamada, Yuji Yamada, Jin Yoneda, Haruo Yoshida, Katsuhiko Yoshida, Daisuke Yoshihara, Fumitaka Yura, J

  5. SU-E-T-278: Dose Conformity Index for the Target in a Multitarget Environment

    Energy Technology Data Exchange (ETDEWEB)

    Harikrishnaperumal, Sudahar [Apollo Speciality Hospital, Chennai, Tamil Nadu (India)

    2015-06-15

    Purpose: The existing conformity index formulations are failing when multiple targets present outside the target of interest with same or different dose prescriptions. In the present study a novel methodology is introduced to solve this issue. Methods: The conformity index used by Nakamura et al (Int J Radiat Oncol Biol Phys 2001; 51(5):1313–1319) is taken as the base for this methodology. In this proposal, the prescription isodose volume (PIV) which normally includes the normal tissue and other target regions is restricted as PIV in annular regions of different thickness around the target of interest. The graphical line plotted between the thickness of annular region and the corresponding conformity index, will increase in the beginning and will reach a flat region, then it will increase again. The second increase in the conformity index depends basically on the distance between the targets, dose prescriptions, and size of the targets. The conformity index in the flat region should be the conformity index of the target of interest. This methodology was validated on dual target environment on a skull phantom in Multiplan planning system (Accuray Inc. Sunnyvale, USA) Results: When the surrounding target’s (sphere) size is changed from 1.5cm to 6cm diameter, the conformity index of the target of interest (3cm diameter) changed from 1.09 to 1.25. When the distance between the targets changed from 7.5cm to 2.5cm, the conformity index changed from 1.10 to 1.17. Similarly, when the prescribed dose changed from 25Gy to 50Gy the conformity index changed from 1.09 to 1.42. These values were above 2.0 when Nakamura et al formula was used. Conclusion: The proposed conformity index methodology eliminates the influence of surrounding targets to a greater extend. However, the limitations of this method should be studied further. Application of this method in clinical situations is the future scope.

  6. Biomarker-based detection of asthma–COPD overlap syndrome in COPD populations

    Directory of Open Access Journals (Sweden)

    Tamada T

    2015-10-01

    Full Text Available Tsutomu Tamada,1 Hisatoshi Sugiura,1 Tsuneyuki Takahashi,2 Kazuto Matsunaga,3 Keiji Kimura,4 Uichiro Katsumata,5 Daisuke Takekoshi,1 Toshiaki Kikuchi,1 Ken Ohta,6 Masakazu Ichinose1 1Department of Respiratory Medicine, Tohoku University Graduate School of Medicine, Sendai, 2Nippon Telegraph and Telephone East Corporation Tohoku Hospital, Sendai, 3Division of Respiratory Medicine and Infectious Disease, Graduate School of Medicine, Yamaguchi University, Ube, 4Hiraka General Hospital, Yokote, 5Iwate Prefectural Isawa Hospital, Oshu, 6National Hospital Organization, Tokyo National Hospital, Kiyose, Tokyo, Japan Abstract: Asthma–chronic obstructive pulmonary disease (COPD overlap syndrome (ACOS was proposed by the science committees of both Global Initiative for Asthma (GINA and Global Initiative for Chronic Obstructive Lung Disease (GOLD. However, the definition of ACOS has remained unclear all over the world, and the prevalence rate of ACOS is basically dependent on the patient’s symptoms or the physician’s opinion, based on questionnaire testing. In the current case report, we investigated the prevalence rate of COPD patients with high levels of fractional exhaled nitric oxide (FENO or immunoglobulin E (IgE as candidate markers of ACOS in COPD, as a multicenter, cross-sectional study. Outpatients with COPD were enrolled from Tohoku University Hospital, Sendai, Japan, and five hospitals (Tohoku University Hospital, Sendai, Japan; NTT East Tohoku Hospital, Sendai, Japan; Wakayama Medical University Hospital, Kimiidera, Japan; Hiraka General Hospital, Yokote, Japan; Iwate Prefectural Isawa Hospital, Oshu, Japan with pulmonary physicians from March 1, 2013 to February 28, 2014. When they were estimated using 35 ppb as the cutoff value of FENO, the prevalence rate of ACOS was 16.3% in COPD. When estimated by both FENO and IgE, the high-FENO/high-IgE group was 7.8% in COPD. To the best of our knowledge, this study is the first to detect the

  7. Graphene oxide scaffold accelerates cellular proliferative response and alveolar bone healing of tooth extraction socket

    Directory of Open Access Journals (Sweden)

    Nishida E

    2016-05-01

    Full Text Available Erika Nishida,1 Hirofumi Miyaji,1 Akihito Kato,1 Hiroko Takita,2 Toshihiko Iwanaga,3 Takehito Momose,1 Kosuke Ogawa,1 Shusuke Murakami,1 Tsutomu Sugaya,1 Masamitsu Kawanami11Department of Periodontology and Endodontology, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan; 2Support Section for Education and Research, Hokkaido University Graduate School of Dental Medicine, Sapporo, Japan; 3Laboratory of Histology and Cytology, Hokkaido University Graduate School of Medicine, Sapporo, JapanAbstract: Graphene oxide (GO consisting of a carbon monolayer has been widely investigated for tissue engineering platforms because of its unique properties. For this study, we fabricated a GO-applied scaffold and assessed the cellular and tissue behaviors in the scaffold. A preclinical test was conducted to ascertain whether the GO scaffold promoted bone induction in dog tooth extraction sockets. For this study, GO scaffolds were prepared by coating the surface of a collagen sponge scaffold with 0.1 and 1 µg/mL GO dispersion. Scaffolds were characterized using scanning electron microscopy (SEM, physical testing, cell seeding, and rat subcutaneous implant testing. Then a GO scaffold was implanted into a dog tooth extraction socket. Histological observations were made at 2 weeks postsurgery. SEM observations show that GO attached to the surface of collagen scaffold struts. The GO scaffold exhibited an interconnected structure resembling that of control subjects. GO application improved the physical strength, enzyme resistance, and adsorption of calcium and proteins. Cytocompatibility tests showed that GO application significantly increased osteoblastic MC3T3-E1 cell proliferation. In addition, an assessment of rat subcutaneous tissue response revealed that implantation of 1 µg/mL GO scaffold stimulated cellular ingrowth behavior, suggesting that the GO scaffold exhibited good biocompatibility. The tissue ingrowth area and DNA contents of 1

  8. Long-term effect of galantamine on cognitive function in patients with Alzheimer’s disease versus a simulated disease trajectory: an observational study in the clinical setting

    Directory of Open Access Journals (Sweden)

    Nakagawa R

    2017-04-01

    Full Text Available Ryoko Nakagawa,1 Takashi Ohnishi,1 Hisanori Kobayashi,1 Toshio Yamaoka,2 Tsutomu Yajima,3 Ai Tanimura,4 Toshiya Kato,4 Kazutake Yoshizawa1 1Evidence Generation Department, Medical Affairs Division, 2Clinical Data Management Department, R&D Division, 3Biostatistics Department, Quantitative Science Division, 4Drug Surveillance Department, R&D Division, Janssen Pharmaceutical K.K., Tokyo, Japan Background: Long-term maintenance of cognitive function is an important goal of treatment for Alzheimer’s disease (AD, but evidence about the long-term efficacy of cholinesterase inhibitors is sparse. To evaluate the long-term efficacy and safety of galantamine for AD in routine clinical practice, we conducted a 72-week post-marketing surveillance study. The effect of galantamine on cognitive function was estimated in comparison with a simulated disease trajectory. Patients and methods: Patients with mild-to-moderate AD received flexible dosing of galantamine (16–24 mg/day during this study. Cognitive function was assessed by the mini mental state examination (MMSE and the clinical status was determined by the Clinical Global Impression-Improvement (CGI-I. Changes of the MMSE score without treatment were estimated in each patient using Mendiondo’s model. Generalized linear mixed model analysis was performed to compare the simulated MMSE scores with the actual scores. Results: Of the 661 patients who were enrolled, 642 were evaluable for safety and 554 were assessed for efficacy. The discontinuation rate was 46.73%. Cognitive decline indicated by the mean change of actual MMSE scores was significantly smaller than the simulated decline. Individual analysis demonstrated that >70% of patients had better actual MMSE scores than their simulated scores. Significant improvement of CGI-I was also observed during the observation period. Adverse events occurred in 28.5% of patients and were serious in 8.41%. The reported events generally corresponded with the

  9. Risk factors for osteoporosis in Japan: is it associated with Helicobacter pylori?

    Directory of Open Access Journals (Sweden)

    Asaoka D

    2015-03-01

    Full Text Available Daisuke Asaoka, Akihito Nagahara, Yuji Shimada, Kenshi Matsumoto, Hiroya Ueyama, Kohei Matsumoto, Yuta Nakagawa, Tsutomu Takeda, Ippei Tanaka, Hitoshi Sasaki, Taro Osada, Mariko Hojo, Sumio Watanabe Department of Gastroenterology, University of Juntendo, School of Medicine, Tokyo, Japan Background: A number of diseases and drugs may influence bone mineral density; however, there are few reports concerning the relationship between lifestyle-related diseases and osteoporosis in Japan as determined by multivariate analysis. The aim of this study was to investigate the risk factors for osteoporosis and whether infection by or eradication of Helicobacter pylori is associated with osteoporosis.Methods: Between February 2008 and November 2014, using a cross-sectional study design, we investigated patient profile (age, sex, BMI, alcohol, smoking, H. pylori infection status, comorbidities, internal medicine therapeutic agents (calcium channel blocker, HMG-CoA reductase inhibitors, proton pump inhibitor, serum parameters (Hb, calcium, ΥGTP, bone turn over markers (bone-specific alkaline phosphatase (BAP and collagen type I cross-linked N telopeptide (NTX, findings on dual-energy x-ray absorptiometry (DEXA and upper gastrointestinal endoscopy, and Frequency Scale for the Symptoms of GERD score in consecutive outpatients aged ≥50 years at our hospital. We divided the subjects into an osteoporosis group and a non-osteoporosis group and investigated risk factors for osteoporosis between the two groups by bivariate and multivariate analyses.Results: Of the 255 eligible study subjects, 43 (16.9% had osteoporosis. Bivariate analysis showed that advanced age, female sex, lower body mass index, lower cumulative alcohol intake, lower Brinkman index, H. pylori positivity, lower hemoglobin, bone-specific alkaline phosphatase, lower prevalence of hiatal hernia, and endoscopic gastric mucosal atrophy were related to osteoporosis. Multivariate analysis showed that

  10. Retinal angiomatous proliferation associated with risk alleles of ARMS2/HTRA1 gene polymorphisms in Japanese patients

    Directory of Open Access Journals (Sweden)

    Ohkuma Y

    2013-12-01

    Full Text Available Yasuhiro Ohkuma,1 Takaaki Hayashi,1 Tsutomu Sakai,1 Akira Watanabe,1 Hisashi Yamada,2 Masakazu Akahori,3 Takeshi Itabashi,3 Takeshi Iwata,3 Toru Noda,4 Hiroshi Tsuneoka11Department of Ophthalmology, 2Department of Molecular Genetics, Institute of DNA Medicine, The Jikei University School of Medicine, 3Division of Molecular and Cellular Biology, National Institute of Sensory Organs, 4Division of Ophthalmology, National Hospital Organization Tokyo Medical Center, Tokyo, JapanBackground: The purpose of this study was to investigate the association between ARMS2/HTRA1, CFH, and C3 gene polymorphisms and retinal angiomatous proliferation (RAP, an infrequent and severe form of exudative age-related macular degeneration, which is characterized by intraretinal neovascularization.Methods: Diagnosis of RAP was based on fundus photographs, images of fluorescein and indocyanine green angiographies, and optical coherence tomography findings. Six single nucleotide polymorphisms (SNPs, A69S (rs10490924 in ARMS2, rs11200638 in HTRA1, I62V (rs800292 in CFH, Y402H (rs1061170 in CFH, R80G (rs2230199 in C3, and rs2241394 in C3, were genotyped in eight Japanese patients with RAP.Results: The two SNPs in the ARMS2/HTRA1 were in complete linkage disequilibrium. The frequency of the risk T allele in ARMS2 (the risk A allele in HTRA1 was 93.8% in the RAP patients. The frequency of homozygosity for the risk genotype TT of ARMS2 (the risk genotype AA of HTRA1 was 87.5%. The frequency of the non-risk allele (A of I62V was 100%. The frequencies of risk alleles of Y402H, R80G, and rs2241394 were 12.5%, 0%, and 18.8%, respectively.Conclusion: Our results suggest that the risk alleles of the ARMS2/HTRA1 SNPs may be associated with development of RAP and play a major role in the pathogenesis of intraretinal angiogenesis.Keywords: age-related macular degeneration, retinal angiomatous proliferation, single nucleotide polymorphisms, ARMS2/HTRA1 genes, components of the complement

  11. Transpupillary thermotherapy for atypical central serous chorioretinopathy

    Directory of Open Access Journals (Sweden)

    Kawamura R

    2012-01-01

    Full Text Available Ryosuke Kawamura1,2, Hidenao Ideta1, Hideyuki Hori1, Kenya Yuki2, Tsuyoshi Uno1, Tatsurou Tanabe1, Kazuo Tsubota2, Tsutomu Kawasaki11Ideta Eye Hospital, Kumamoto, Japan; 2Keio University, School of Medicine, Department of Ophthalmology, Tokyo, JapanBackground: Central serous chorioretinopathy (CSC has been traditionally treated with laser photocoagulation. We thought that transpupillary thermotherapy (TTT utilizing a lower temperature than that of conventional laser photocoagulation might minimize permanent retinal and choroidal damage. Studies suggest that undesirable effects on vision due to TTT are minimal even if it is applied to foveal and/or parafoveal lesions when TTT requires a larger irradiation spot. The aim of this study was to evaluate the efficacy of TTT in the management of atypical CSC.Methods: We defined atypical CSC as bullous retinal detachment with diffuse or several leakages, severe leakage with fibrin formation under serous retinal detachment, or leakage within a pigment epithelium detachment. Eight consecutive patients with atypical CSC underwent visual acuity testing, ophthalmic examination, color photography, fluorescein angiography, and optical coherence tomography to evaluate the results of transpupillary thermotherapy. Retreatment of atypical CSC was based on ophthalmic examination, optical coherence tomography, and fluorescein angiography. TTT was performed on the leaking spots shown in fluorescein angiography, with a power of 50–250 mW, spot size of 500–1200 µm, and exposure time of 13–60 seconds to minimize retinal damage.Results: In five of eight affected eyes, serous detachments completely resolved within 1 month after the initial TTT. One eye had persistent subretinal fluid and required a second TTT treatment. Two eyes showed no resolution of CSC and were treated by conventional photocoagulation. Initial best-corrected visual acuity (BCVA ranged from 20/600 to 20/20 (mean, 20/40; median, 20/30. Final BCVA

  12. Tipepidine in children with attention deficit/hyperactivity disorder: a 4-week, open-label, preliminary study

    Directory of Open Access Journals (Sweden)

    Sasaki T

    2014-01-01

    Full Text Available Tsuyoshi Sasaki,1,2 Kenji Hashimoto,3 Masumi Tachibana,1 Tsutomu Kurata,1 Keiko Okawada,1 Maki Ishikawa,1 Hiroshi Kimura,2 Hideki Komatsu,2 Masatomo Ishikawa,2 Tadashi Hasegawa,2 Akihiro Shiina,1 Tasuku Hashimoto,2 Nobuhisa Kanahara,3 Tetsuya Shiraishi,2 Masaomi Iyo1–31Department of Child Psychiatry, Chiba University Hospital, 2Department of Psychiatry, Chiba University Graduate School of Medicine, 3Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, Chiba, JapanBackground: Tipepidine (3-[di-2-thienylmethylene]-1-methylpiperidine has been used solely as a nonnarcotic antitussive in Japan since 1959. The safety of tipepidine in children and adults has already been established. It is reported that tipepidine inhibits G-protein-coupled inwardly rectifying potassium (GIRK-channel currents. The inhibition of GIRK channels by tipepidine is expected to modulate the level of monoamines in the brain. We put forward the hypothesis that tipepidine can improve attention deficit/hyperactivity disorder (ADHD symptoms by modulating monoaminergic neurotransmission through the inhibition of GIRK channels. The purpose of this open-label trial was to confirm whether treatment with tipepidine can improve symptoms in pediatric patients with ADHD.Subjects and methods: This was a 4-week, open-label, proof-of-efficacy pilot study for pediatric subjects with ADHD. Ten pediatric ADHD subjects (70% male; mean age, 9.9 years; combined [inattentive and hyperactive/impulsive] subtype, n=7; inattentive subtype, n=3; hyperimpulsive subtype, n=0 received tipepidine hibenzate taken orally at 30 mg/day for 4 weeks. All subjects were assessed using the ADHD Rating Scale IV (ADHD-RS, Japanese version, and the Das–Naglieri Cognitive Assessment System (DN-CAS, Japanese version.Results: A comparison of baseline scores and 4-week end-point scores showed that all the ADHD-RS scores (total scores, hyperimpulsive subscores, and inattentive subscores

  13. PREFACE: Nanospintronics design and realization

    Science.gov (United States)

    Akai, Hisazumi; Katayama-Yoshida, Hiroshi; Kasai, Hideaki

    2004-12-01

    oral presentations and 44 contributed posters. The conference also has additional financial support from the Asahi Glass Foundation, the Foundation for Promotion of Material Science and Technology of Japan, the Izumi Science and Technology Foundation, the Kansai Research Foundation for Technology Promotion, the Kao Foundation for Arts and Sciences, the Murata Science Foundation, the Nanotechnology Researchers Network Center of Japan, and the Nippon Sheet Glass Foundation for Materials Science and Engineering. The 2nd International Conference on Nanospintronics Design and Realization will be held in Germany, in 2007, and will be organized by Stefan Blügel, Patrick Bruno, and Dieter Weiss. We hope to see you there.

  14. Condensation heat transfer characteristics of vapor flow in vertical small-diameter tube with variable wall temperature

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    [1]Nusselt,W.,Die Oberflchenkondensation des Wasserdampfes,VDI,1916,60: 541-546.[2]Sparrow,E.M.,Gregg,J.L.,A boundary layer treatment of laminar-film condensation,ASME J.Heat Transfer,1959,81: 13-18.[3]Mayhew,Y.R.,Griffiths,D.J.,Philips,J.W.,Effect of vapour drag on laminar film condensation on a vertical surface,Proc.I Mech.E,1965,180: 280-287.[4]Memory,S.B.,Rose,J.W.,Free convection laminar film condensation on a horizontal tube with variable wall temperature,Int.J.Heat Mass Transfer,1991,34: 2775-2778.[5]Suzuki,K.,Hagiwara,Y.,Izumi,H.,A numerical study of forced-convective filmwise condensation in a vertical tube,JSME Int.J.,Ser.II,1990,33(1): 134-140.[6]Shah,M.M.,A general correlation for heat transfer during film condensation inside pipes,Int.J.Heat Mass Transfer,1979,22: 547-556.[7]Reay,D.A.,Compact heat exchangers: a review of current equipment and R&D in the field,Heat Recovery System & CHP,1994,14(5): 459-479.[8]Srinivasan,V.,Shah,R.K.,Condensation in compact heat exchangers,J.Enhanced Heat Transfer,1997,4(4): 237-256.[9]Wadekar,V.V.,Improving industrial heat transfer-compact and non-so-compact heat exchangers,J.Enhanced Heat Transfer,1998,5(1): 53-69.[10]Rohsenow,W.M.,Film Condensation,Applied Mechanics Reviews,1970,23: 487-496.[11]Wang Buxuan,Yu Yufeng,Condensation heat transfer on the external surface of a small-diameter vertical tube (in Chinese),in Collected Papers of Bu-xuan Wang,Beijing: Tsinghua University Press,1992.[12]Henstock,W.H.,Hodgson,T.J.,The interfacial drag and height of the wall layer in annular flows,AIChE J.,1976,22: 990-1000.[13]Wang Buxuan,Du Xiaoze,Study on laminar film-wise condensation for vapor flow in an inclined small/mini-diameter tube,Int.J.Heat Mass Transfer,2000,43(10): 1859-1868.[14]Wang Buxuan,Du Xiaoze,Experimental research on flow condensation heat transfer in mini-diameter tube (in Chinese with English abstract),Chinese J.Engineering Thermophysics,2000

  15. Task-based Language Learning in Bilingual Montessori Elementary Schools: Customizing Foreign Language Learning and Promoting L2 Speaking Skills

    Directory of Open Access Journals (Sweden)

    Jana Winnefeld

    2012-01-01

    Full Text Available Foreign language learning has been a part of German elementary schools for several years now. Montessori schools focusing on individual learning, i.e. mostly independent from the teacher and based on auto-education, interest, and free choice, are also asked to teach an L2. The original lack of a concept of L2 learning for this environment has brought forth different approaches. Bilingual education seems to be feasible and applicable in Montessori education. The downside to this is that even in a bilingual classroom the Montessori way of learning may not allow for very much oral production of the foreign language. The role of L2 production (cf. Swain 1985, 1995, 2005 for language acquisition has been theoretically claimed and empirically investigated. Output can have a positive influence on L2 learning (cf. e.g. Izumi 2002, Keck et al. 2006. This also applies to interaction (cf. Long 1996, where negotiation of meaning and modified output are factors supporting L2 development (cf. e.g. de la Fuente 2002, McDonough 2005. Task-based Language Learning (TBLL presents itself as one way to promote oral language production and to provide opportunities for meaning-negotiation. Especially tasks with required information exchange and a closed outcome have been shown to be beneficial for the elicitation of negotiation of meaning and modified output. This paper argues that TBLL is a promising approach for the facilitation of L2 production and thus the development of speaking skills in a Montessori context. It also hypothesizes that TBLL can be implemented in a bilingual Montessori environment while still making the Montessori way of learning possible. Different tasks on various topics, examples of which are presented in this article, can lay the foundation for this. Offering such tasks in a bilingual Montessori elementary classroom promises to foster language production and the use of communication strategies like negotiation of meaning, both being

  16. Activities of daily living as an additional predictor of complications and outcomes in elderly patients with acute myocardial infarction

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    Nakajima H

    2016-08-01

    Full Text Available Hiroyuki Nakajima,1 Jiro Yoshioka,2 Nobuyuki Totsuka,2 Izumi Miyazawa,2 Tatsuya Usui,2 Nobuyuki Urasawa,2 Takahiro Kobayashi,3 Tomoaki Mochidome4 1Department of Cardiology, Nagano Matsushiro General Hospital, 2Department of Cardiology, Nagano Red Cross Hospital, 3Department of Cardiology, Nagano Municipal Hospital, Nagano, 4Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan Background: Age is an important determinant of outcome in acute myocardial infarction (AMI. However, in clinical settings, there is an occasional mismatch between chronological age and physical age. We evaluated whether activities of daily living (ADL, which reflect physical age, also predict complications and prognosis in elderly patients with AMI.Design: Single-center, observational, and retrospective cohort study.Methods: Preserved ADL and low ADL were defined according to the scale for independence degree of daily living for the disabled elderly by the Japanese Ministry of Health, Labour, and Welfare. We examined 82 consecutive patients aged ≥75 years with AMI who underwent primary percutaneous coronary intervention. Patients were divided into preserved ADL (n=52; mean age, 81.8±4.8 years; male, 59.6% and low ADL (n=30; mean age, 85.8±4.7 years; male, 40.0% groups according to prehospital ADL.Results: The prevalence of Killip class II–IV and in-hospital mortality rate were significantly higher with low ADL compared to that with preserved ADL (23.1% vs 60.0%, P=0.0019; 5.8% vs 30.0%, P=0.0068, respectively. Multivariate analysis showed that ADL was an independent predictor of Killip class II–IV and 1-year mortality after adjusting for age, sex, and other possible confounders (odds ratio 5.11, 95% confidence interval [CI] 1.52–17.2, P=0.0083; hazard ratio 4.32, 95% CI 1.31–14.3, P=0.017, respectively.Conclusion: Prehospital ADL is a significant predictor of heart failure complications and prognosis in elderly

  17. Continuous H/V spectral ratio analysis of ambient noise: a necessity to understand microzonation results obtained by mobile stations

    Science.gov (United States)

    Van Noten, Koen; Lecocq, Thomas

    2016-04-01

    Estimating the resonance frequency (f0) and amplification factor of unconsolidated sediments by H/V spectral ratio (HVSR) analysis of seismic ambient noise has been widely used since Nakamura's proposal in 1989. To measure f0 properly, Nakamura suggested to perform microzonation surveys at night when the artificial microtremor is small and does not fully disrupt the ambient seismic noise. As nightly fieldwork is not always a reasonable demand, we propose an alternative workflow of Nakamura's technique to improve the quality of HVSR results obtained by ambient noise measurements of mobile stations during the day. This new workflow includes the automated H/V calculation of continuous seismic data of a stationary or permanent station installed near the microzonation site for as long as the survey lasts in order to control the error in the HVSR analysis obtained by the mobile stations. In this presentation, we apply this workflow on one year of seismic data at two different case studies; i.e. a rural site with a shallow bedrock depth of 30 m and an urban site (Brussels, capital of Belgium, bedrock depth of 110 m) where human activity is continuous 24h/day. By means of an automated python script, the fundamental peak frequency and the H/V amplitude are automatically picked from H/V spectra that are calculated from 50% overlapping, 30 minute windows during the whole year. Afterwards, the f0 and amplitude picks are averaged per hour/per day for the whole year. In both case studies, the H/V amplitude and the fundamental frequencies range considerable, up to ˜15% difference between the daily and nightly measurements. As bedrock depth is known from boreholes at both sites, we concluded that the nightly picked f0 is the true one. Our results thus suggest that changes in the determined f0 and H/V amplitude are dominantly caused by the human behaviour which is stored in the ambient seismic noise (e.g. later onset of traffic in a weekend, quiet Sundays, differences between

  18. Signatures of cosmic-ray increase attributed to exceptional solar storms inferred from multiple cosmogenic radionuclide records

    Science.gov (United States)

    Mekhaldi, Florian; Muscheler, Raimund; Adolphi, Florian; Svensson, Anders; Aldahan, Ala; Possnert, Göran; McConnell, Joseph R.; Sigl, Michael; Welten, Kees C.; Woodruff, Thomas E.

    2014-05-01

    Miyake et al. (2012, 2013) discovered rapid increases of 14C content in tree rings dated to AD 774-5 and AD 993-4 which they have attributed to cosmic-ray events. These extreme particle events have no counterparts in the instrumental record and have been tentatively associated with solar proton events, supernovae and short gamma-ray bursts, which have very different energy spectra. Cosmogenic radionuclides such as 14C, 10Be and 36Cl arise from the interaction of cosmic rays with atmospheric nitrogen, oxygen and argon. These radio-isotopes are produced through different reaction pathways and vary with different energy dependencies of the production rate cross section. Owing to this, yield functions can be used to determine the energy level of incident particles. However, only 14C has been measured at high resolution to quantify the energy and thus the origin of the outbursts. We present an annually resolved record of 10Be from the NGRIP ice core for the two events. In addition, we also utilized the GRIP ice core 36Cl record in our analysis. Our results show that the differential production of cosmogenic 14C, 10Be and 36Cl is consistent with a solar energy spectrum. Considering the notable increase in radionuclides, the solar storms would have had to be substantially greater than the largest recorded geomagnetic storm, the so-called Carrington event. This challenges our understanding of the sun's dynamics. Furthermore, the events could possibly be of interest for the investigation of potential cosmic ray-cloud linkages (Svensmark & Friis-Christensen, 1997). Alternatively, such outbursts of energetic particles have the potential to deplete atmospheric ozone and alter atmospheric circulation. Ultimately, the magnitude of such particle events draws attention to the perhaps underestimated potential of the sun to cause great damage to modern technologies. References Miyake, F., Masuda, K. & Nakamura, T. Another rapid event in the carbon-14 content of tree rings. Nature

  19. Shakespeare translation in Japan: 1868—1998 Shakespeare translation in Japan: 1868—1998

    Directory of Open Access Journals (Sweden)

    Akiko Sano

    2008-04-01

    Full Text Available Shakespeare was first introduced to Japan in the late nineteenth century, when the country opened its doors to other countries after the seclusion policy of over two hundred years. When the Meiji Restoration Government came into power in 1868, it decided to import the Western culture and technology in order to catch up with the developed countries. Japan’s overall contact with the Western world began. The country’s slogan then became “civilization and enlightenment”, which meant Westernization for “national wealth and military strength”. Shakespeare came to Japan together with other things from Britain during this age of Westernization. The translation of two English books were published in 1871 and 1872 to enlighten the youth of the new age. One was Samuel Smiles’ Self-Help (1859 and the other was John Stuart Mill’s On Liberty (1859. Both books acquired immediate popularity. The translator was Masanao Nakamura who was originally sent by the old Tokugawa Government to Britain to study English. Shakespeare was first introduced to Japan in the late nineteenth century, when the country opened its doors to other countries after the seclusion policy of over two hundred years. When the Meiji Restoration Government came into power in 1868, it decided to import the Western culture and technology in order to catch up with the developed countries. Japan’s overall contact with the Western world began. The country’s slogan then became “civilization and enlightenment”, which meant Westernization for “national wealth and military strength”. Shakespeare came to Japan together with other things from Britain during this age of Westernization. The translation of two English books were published in 1871 and 1872 to enlighten the youth of the new age. One was Samuel Smiles’ Self-Help (1859 and the other was John Stuart Mill’s On Liberty (1859. Both books acquired immediate popularity. The translator was Masanao Nakamura who was

  20. Frontiers in Numerical Relativity

    Science.gov (United States)

    Evans, Charles R.; Finn, Lee S.; Hobill, David W.

    2011-06-01

    Preface; Participants; Introduction; 1. Supercomputing and numerical relativity: a look at the past, present and future David W. Hobill and Larry L. Smarr; 2. Computational relativity in two and three dimensions Stuart L. Shapiro and Saul A. Teukolsky; 3. Slowly moving maximally charged black holes Robert C. Ferrell and Douglas M. Eardley; 4. Kepler's third law in general relativity Steven Detweiler; 5. Black hole spacetimes: testing numerical relativity David H. Bernstein, David W. Hobill and Larry L. Smarr; 6. Three dimensional initial data of numerical relativity Ken-ichi Oohara and Takashi Nakamura; 7. Initial data for collisions of black holes and other gravitational miscellany James W. York, Jr.; 8. Analytic-numerical matching for gravitational waveform extraction Andrew M. Abrahams; 9. Supernovae, gravitational radiation and the quadrupole formula L. S. Finn; 10. Gravitational radiation from perturbations of stellar core collapse models Edward Seidel and Thomas Moore; 11. General relativistic implicit radiation hydrodynamics in polar sliced space-time Paul J. Schinder; 12. General relativistic radiation hydrodynamics in spherically symmetric spacetimes A. Mezzacappa and R. A. Matzner; 13. Constraint preserving transport for magnetohydrodynamics John F. Hawley and Charles R. Evans; 14. Enforcing the momentum constraints during axisymmetric spacelike simulations Charles R. Evans; 15. Experiences with an adaptive mesh refinement algorithm in numerical relativity Matthew W. Choptuik; 16. The multigrid technique Gregory B. Cook; 17. Finite element methods in numerical relativity P. J. Mann; 18. Pseudo-spectral methods applied to gravitational collapse Silvano Bonazzola and Jean-Alain Marck; 19. Methods in 3D numerical relativity Takashi Nakamura and Ken-ichi Oohara; 20. Nonaxisymmetric rotating gravitational collapse and gravitational radiation Richard F. Stark; 21. Nonaxisymmetric neutron star collisions: initial results using smooth particle hydrodynamics

  1. Extreme QCD 2012 (xQCD)

    Science.gov (United States)

    2013-04-01

    Acknowledgements This conference would not have been possible without the generous support from Brookhaven National Laboratory and the George Washington University INS and IMPACT institutes, Columbian College of Arts and Sciences, the Office of Vice-President for Research, and the Department of Physics. We thank them wholeheartedly. We are also very grateful for the support of our colleagues on the local organizing committee, Walter Freeman and Frank Lee, and on the International Advisory Committee: Simon Hands, Tetsuo Hatsuda, Frithjof Karsch, Maria Paola Lombardo, Tereza Mendes, Atsushi Nakamura, Owe Philipsen, Claudia Ratti, Paul Romatschke, Misha Stephanov, and Nu Xu. List of participants Alexandru, Andrei George Washington University Bazavov, Alexei Brookhaven National Laboratory Bloch, Jacques University of Regensburg Braun-Munzinger, Peter EMMI, GSI Breto Rangel, Guillermo CMS/UC Davis D'Elia, Massimo University of Pisa, INFN Dexheimer, Veronica UFSC - Federal University of Santa Catarina Ding, Heng-Tong Brookhaven National Laboratory Dion, Alan Stony Brook University Dumitru, Adrian RBRC and Baruch College, CUNY Freeman, Walter George Washington University Gavai, Rajiv Tata Institute (TIFR), Mumbai Hanada, Masanori KEK Theory Center Hands, Simon Swansea University Hegde, Prasad Brookhaven National Laboratory Heinke, Craig University of Alberta Horvath, Ivan University of Kentucky Karsch, Frithjof Brookhaven National Laboratory Krieg, Stefan Wuppertal University Lattimer, James Stony Brook University Lee, Frank George Washington University Li, Anyi Institute for Nuclear Theory Liu, Keh-Fei University of Kentucky Lombardo, Maria Paola INFN - LNF Lottini, Stefano Goethe University, Frankfurt am Main Maezawa, Yu Brookhaven National Laboratory Miura, Kohtaroh Laboratori Nazionali di Frascati - INFN Monnai, Akihiko The University of Tokyo Mukherjee, Swagato Brookhaven National Laboratory Myers, Joyce University of Groningen Nakamura, Atsushi RIISE, Hiroshima

  2. Supernovae and Gamma-Ray Bursts

    Science.gov (United States)

    Livio, Mario; Panagia, Nino; Sahu, Kailash

    2001-07-01

    Participants; Preface; Gamma-ray burst-supernova relation B. Paczynski; Observations of gamma-ray bursts G. Fishman; Fireballs T. Piran; Gamma-ray mechanisms M. Rees; Prompt optical emission from gamma-ray bursts R. Kehoe, C. Akerlof, R. Balsano, S. Barthelmy, J. Bloch, P. Butterworth, D. Casperson, T. Cline, S. Fletcher, F. Frontera, G. Gisler, J. Heise, J. Hills, K. Hurley, B. Lee, S. Marshall, T. McKay, A. Pawl, L. Piro, B. Priedhorsky, J. Szymanski and J. Wren; X-ray afterglows of gamma-ray bursts L. Piro; The first year of optical-IR observations of SN1998bw I. Danziger, T. Augusteijn, J. Brewer, E. Cappellaro, V. Doublier, T. Galama, J. Gonzalez, O. Hainaut, B. Leibundgut, C. Lidman, P. Mazzali, K. Nomoto, F. Patat, J. Spyromilio, M. Turatto, J. Van Paradijs, P. Vreeswijk and J. Walsh; X-ray emission of Supernova 1998bw in the error box of GRB980425 E. Pian; Direct analysis of spectra of type Ic supernovae D. Branch; The interaction of supernovae and gamma-ray bursts with their surroundings R. Chevalier; Magnetars, soft gamma-ray repeaters and gamma-ray bursts A. Harding; Super-luminous supernova remnants Y. -H. Chu, C. -H. Chen and S. -P. Lai; The properties of hypernovae: SNe Ic 1998bw, 1997ef, and SN IIn 1997cy K. Nomoto, P. Mazzali, T. Nakamura, K. Iwanmoto, K. Maeda, T. Suzuki, M. Turatto, I. Danziger and F. Patat; Collapsars, Gamma-Ray Bursts, and Supernovae S. Woosley, A. MacFadyen and A. Heger; Pre-supernova evolution of massive stars N. Panagia and G. Bono; Radio supernovae and GRB 980425 K. Weiler, N. Panagia, R. Sramek, S. Van Dyk, M. Montes and C. Lacey; Models for Ia supernovae and evolutionary effects P. Hoflich and I. Dominguez; Deflagration to detonation A. Khokhlov; Universality in SN Iae and the Phillips relation D. Arnett; Abundances from supernovae F. -K. Thielemann, F. Brachwitz, C. Freiburghaus, S. Rosswog, K. Iwamoto, T. Nakamura, K. Nomoto, H. Umeda, K. Langanke, G. Martinez-Pinedo, D. Dean, W. Hix and M. Strayer; Sne, GRBs, and the

  3. 3D Geotechnical Soil Model of Nice, France, Inferred from Seismic Noise Measurements, for Seismic Hazard Assessment.

    Science.gov (United States)

    Bertrand, E.; Duval, A.; Castan, M.; Vidal, S.

    2007-12-01

    relationship. We measured ambient vibration at almost 500 points homogeneously distributed in the city of Nice. The recordings were processed according to the Nakamura technique (Nakamura, 1989) obtaining thus the fundamental resonance frequency of the sedimentary infill at each recording point. Adding to this data set some earthquake recordings from the French permanent accelerometric network (RAP) in Nice and a microtremor array recording (Bonnefoy-Claudet, 2004), we were able to better constrain the subsurface model of Nice as well as to extend it where no boreholes were existing. This paper shows the good agreement we observed between geotechnical data and ambient vibration recordings. It particularly points out the contribution of seismological surveys in the subsurface modeling.

  4. PREFACE: International Symposium "Nanoscience and Quantum Physics 2011" (nanoPHYS'11)

    Science.gov (United States)

    Saito, Susumu; Tanaka, Hidekazu; Nakamura, Takashi; Nakamura, Masaaki

    2011-07-01

    authors, the referees, and all the individuals involved in the symposium organization, in particular, all the committee members and secretaries who helped to make this symposium so successful. The organizing committee would like to take this opportunity to thank the invited speakers, the session chairs, and all the attendees for their contribution to the symposium. Susumu Saito, Hidekazu Tanaka, Takashi Nakamura and Masaaki Nakamura, Editors Conference photograph

  5. A comparison between amblyopic and fellow eyes in unilateral amblyopia using spectral-domain optical coherence tomography

    Directory of Open Access Journals (Sweden)

    Araki S

    2014-11-01

    Full Text Available Syunsuke Araki,1 Atsushi Miki,1,2 Tsutomu Yamashita,1,2 Katsutoshi Goto,1,2 Kazuko Haruishi,1 Yoshiaki Ieki,1 Junichi Kiryu1 1Department of Ophthalmology, Kawasaki Medical School, Kurashiki, Japan; 2Department of Sensory Science, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare, Kurashiki, Japan Purpose: To compare the macular retinal thickness and characteristics of optic nerve head (ONH parameters in amblyopic and fellow eyes in patients with unilateral amblyopia.Patients and methods: A total of 21 patients with unilateral amblyopia (14 patients with anisometropic amblyopia, four patients with strabismic amblyopia, and three patients with both were examined using spectral-domain optical coherence tomography. The mean age of the patients was 8.5±3.5 years. The examined parameters included the mean macular (full, inner, and outer, ganglion cell complex and circumpapillary retinal nerve fiber layer (cpRNFL thicknesses, and ONH parameters (rim volume, nerve head volume, cup volume, rim area, optic disc area, cup area, and cup-to-disc area ratio.Results: The amblyopic eyes were significantly more hyperopic than the fellow eyes (P<0.001. Among the macular retinal thickness parameters, the cpRNFL thickness (P<0.01, macular full retinal thickness (3 mm region (P<0.01, and macular outer retinal thickness (1 and 3 mm regions (P<0.05 were significantly thicker in the amblyopic eyes than in the fellow eyes, while the ganglion cell complex thickness, macular full retinal thickness (1 mm region, and macular inner retinal thickness (1 and 3 mm regions were not significantly different. Among the ONH parameters, the rim area was significantly larger and the cup-to-disc area ratio was smaller in the amblyopic eyes than in the fellow eyes (P<0.05. None of the other ONH parameters were significantly different between the investigated eyes. The differences in the cpRNFL thickness and macular outer retinal thickness in the 1 mm

  6. PREFACE: 7th International Conference on Applications of Physics in Financial Analysis

    Science.gov (United States)

    Takayasu, M.; Watanabe, T.; Ikeda, Y.; Takayasu, H.

    2010-04-01

    become interested in such datasets, conducting empirical investigations about various aspects of economic activities. Specifically, they have searched for regularities and 'laws' akin to the ones in natural science, successfully producing fascinating results, as shown in the papers contained in this volume. Each paper submitted for publication in this volume has gone through the refereeing process, and has been revised on the basis of comments and discussion at the conference as well as comments from the anonymous referees. Finally, 19 papers were accepted for publication. The editors are very grateful to the colleagues involved in the refereeing process for their rapid and careful reviewing of the papers. We thank Takayuki Mizuno, Koji Sakai, Hiwon Yoon and Hiroki Matsui for their support for the conference. We appreciate the administrative assistance provided by Yayoi Hatano of Hitotsubashi University, and Masahiko Ozaki, Masato Yamada and Tomoko Kase of RIETI. We are most grateful to the authors for their contributions, as well as to the participants, all of whom made this conference stimulating and enjoyable. Misako Takayasu Tokyo Institute of Technology, Japan Tsutomu Watanabe Hitotsubashi University, Japan RIETI, Japan Yuichi Ikeda Hitachi Research Laboratory, Hitachi Ltd, Japan Hideki Takayasu Sony Computer Science Laboratories, Inc, Japan

  7. PREFACE: 14th International Conference on Micro and Nanotechnology for Power Generation and Energy Conversion Applications (PowerMEMS 2014)

    Science.gov (United States)

    2014-11-01

    create strong networks between researchers. We also provide nice opportunities to experience Japanese nature and culture. The special cruise to see the magnificent whirlpool up close will definitely be one of the highlights. Additionally, we will serve Awaji's traditional performing art, Awaji Ningyo Joruri, which has a history of over 500 years and has been inherited through the generations. There are many individuals we would like to thank for their support in organizing PowerMEMS2014. The TPC, chaired by Takayuki Fujita, have given us their valuable time and best effort in reviewing abstracts. The PowerMEMS School chair Yuji Suzuki and the expert speakers made the School possible. The local organizing committee, led by Kensuke Kanda has provided us with invaluable assistance in preparing the PowerMEMS2014 venue. The financial support from both the Tsutomu Nakauchi Foundation, the Hyogo International Association and the conference sponsors have also been gratefully appreciated. Finally, we would like to thank each of you for attending the conference and bringing your expertise. We wish you all a successful conference and an exciting and relaxing stay in Awaji Island.

  8. A numerical study of magnetohydrodynamic transport of nanofluids over a vertical stretching sheet with exponential temperature-dependent viscosity and buoyancy effects

    Science.gov (United States)

    Akbar, Noreen Sher; Tripathi, Dharmendra; Khan, Zafar Hayat; Bég, O. Anwar

    2016-09-01

    In this paper, a mathematical study is conducted of steady incompressible flow of a temperature-dependent viscous nanofluid from a vertical stretching sheet under applied external magnetic field and gravitational body force effects. The Reynolds exponential viscosity model is deployed. Electrically-conducting nanofluids are considered which comprise a suspension of uniform dimension nanoparticles suspended in viscous base fluid. The nanofluid sheet is extended with a linear velocity in the axial direction. The Buonjiornio model is utilized which features Brownian motion and thermophoresis effects. The partial differential equations for mass, momentum, energy and species (nano-particle concentration) are formulated with magnetic body force term. Viscous and Joule dissipation effects are neglected. The emerging nonlinear, coupled, boundary value problem is solved numerically using the Runge-Kutta fourth order method along with a shooting technique. Graphical solutions for velocity, temperature, concentration field, skin friction and Nusselt number are presented. Furthermore stream function plots are also included. Validation with Nakamura's finite difference algorithm is included. Increasing nanofluid viscosity is observed to enhance temperatures and concentrations but to reduce velocity magnitudes. Nusselt number is enhanced with both thermal and species Grashof numbers whereas it is reduced with increasing thermophoresis parameter and Schmidt number. The model is applicable in nano-material manufacturing processes involving extruding sheets.

  9. Engineering seismological studies in and around Zagazig city, Sharkia, Egypt

    Directory of Open Access Journals (Sweden)

    M. El-Eraki

    2012-12-01

    Full Text Available The aim of this paper is to study the ground vibrations using Nakamura technique to evaluate the relation between the ground conditions and the earthquake characteristics. Microtremor measurements were carried out at 55 sites in and around Zagazig city. The signals were processed using horizontal to vertical spectral ratio (HVSR technique to estimate the fundamental frequencies of the soil deposits and its corresponding H/V amplitude. Seismic measurements were acquired at nine sites for recording the surface waves. The recorded waveforms were processed using the multi-channel analysis of surface waves (MASW method to infer the shear wave velocity profile. The obtained fundamental frequencies were found to be ranging from 0.7 to 1.7 Hz and the maximum H/V amplitude reached 6.4. These results together with the average shear wave velocity in the surface layers were used for the estimation of the thickness of the upper most soft cover layers (depth to bedrock. The sediment thickness generally increases at the northeastern and southwestern parts of the area which is in good agreement with the local geological structure. The results of this work showed the zones of higher potential damage in the event of an earthquake in the study area.

  10. Restoration and Reexamination of Apollo Lunar Dust Detector Data from Original Telemetry Files

    Science.gov (United States)

    McBride, M. J.; Williams, David R.; Hills, H. Kent

    2012-01-01

    We are recovering the original telemetry (Figure I) from the Apollo Dust, Thermal, Radiation Environment Monitor (DTREM) experiment, more commonly known as the Dust Detector, and producing full time resolution (54 second) data sets for release through the Planetary Data System (PDS). The primary objective of the experiment was to evaluate the effect of dust deposition, temperature, and radiation damage on solar cells on the lunar surface. The monitor was a small box consisting of three solar cells and thermistors mounted on the ALSEP (Apollo Lunar Surface Experiments Package) central station. The Dust Detector was carried on Apollo's 11, 12, 14 and 15. The Apollo 11 DTREM was powered by solar cells and only operated for a few months as planned. The Apollo 12, 14, and 15 detectors operated for 5 to 7 years, returning data every 54 seconds, consisting of voltage outputs from the three solar cells and temperatures measured by the three thermistors. The telemetry was received at ground stations and held on the Apollo Housekeeping (known as "Word 33") tapes. made available to the National Space Science Data Center (NSSDC) by Yosio Nakamura (University of Texas Institute for Geophysics). We have converted selected parts of the telemetry into uncalibrated and calibrated output voltages and temperatures.

  11. An improved method for correction of air temperature measured using different radiation shields

    Science.gov (United States)

    Cheng, Xinghong; Su, Debin; Li, Deping; Chen, Lu; Xu, Wenjing; Yang, Meilin; Li, Yongcheng; Yue, Zhizhong; Wang, Zijing

    2014-11-01

    The variation of air temperature measurement errors using two different radiation shields (DTR502B Vaisala, Finland, and HYTFZ01, Huayun Tongda Satcom, China) was studied. Datasets were collected in the field at the Daxing weather station in Beijing from June 2011 to May 2012. Most air temperature values obtained with these two commonly used radiation shields were lower than the reference records obtained with the new Fiber Reinforced Polymers (FRP) Stevenson screen. In most cases, the air temperature errors when using the two devices were smaller on overcast and rainy days than on sunny days; and smaller when using the imported rather than the Chinese shield. The measured errors changed sharply at sunrise and sunset, and reached maxima at noon. Their diurnal variation characteristics were, naturally, related to changes in solar radiation. The relationships between the record errors, global radiation, and wind speed were nonlinear. An improved correction method was proposed based on the approach described by Nakamura and Mahrt (2005) (NM05), in which the impact of the solar zenith angle (SZA) on the temperature error is considered and extreme errors due to changes in SZA can be corrected effectively. Measurement errors were reduced significantly after correction by either method for both shields. The error reduction rate using the improved correction method for the Chinese and imported shields were 3.3% and 40.4% higher than those using the NM05 method, respectively.

  12. Ambient noise H/V spectral ratio in site effects estimation in Fateh jang area, Pakistan

    Institute of Scientific and Technical Information of China (English)

    S.M.Talha Qadri; Bushra Nawaz; S.H.Sajjad; Riaz Ahmad Sheikh

    2015-01-01

    Local geology or local site effect is a crucial component while conducting seismic risk assessment studies.Investigations made by utilization of ambient noise are an effective tool for local site estimation.The present study is conducted to perform site response analysis at 13 different sites within urban settlements of Fateh jang area (Pakistan).The aim of this study was achieved by utilizing Nakamura method or H/V spectral ratio method.Some important local site parameters,e.g.,the fundamental frequencies f0 of soft sediments,amplitudes A0 of corresponding H/V spectral ratios,and alluvium thicknesses over 13 sites within the study area,were measured and analyzed.The results show that the study area reflects low fundamental frequency f0.The fundamental frequencies of the sediments are highly variable and lie in a range of 0.6-13.0 Hz.Similarly,amplification factors at these sites are in the range of 2.0-4.0.

  13. Comparison of Semi-Lagrangian Algorithms for Solving Vlasov-type Equations

    Science.gov (United States)

    Brunner, Stephan

    2005-10-01

    In view of pursuing CRPP's effort in carrying out gyrokinetic simulations using an Eulerian-type approach [M. Brunetti et. al, Comp. Phys. Comm. 163, 1 (2004)], different alternative algorithms have been considered. The issue is to identify the most appropriate time-stepping scheme, both from a point of view of numerical accuracy and numerical efficiency. Our efforts have concentrated on two semi-Lagrangian approaches: The widely used cubic B-spline interpolation scheme, based on the original work of Cheng and Knorr [C. Z. Cheng and G. Knorr, J. Comp. Phys. 22, 330 (1976)], as well as the Cubic Interpolation Propagation (CIP) scheme, based on cubic Hermite interpolation, which has only more recently been applied for solving Vlasov-type equations [T. Nakamura and T. Yabe, Comp. Phys. Comm. 120, 122 (1999)]. The systematic comparison of these algorithms with respect to their basic spectral (diffusion/dispersion) properties, as well as their ability to avoid the overshoot (Gibbs) problem, is first presented. Results from solving a guiding-center model of the two-dimensional Kelvin-Helmholtz instability are then compared. This test problem enables to address some of the key technical issues also met with the more complex gyrokinetic-type equations.

  14. Laser mass spectrometry for DNA fingerprinting for forensic applications

    Energy Technology Data Exchange (ETDEWEB)

    Chen, C.H.; Tang, K.; Taranenko, N.I.; Allman, S.L.; Chang, L.Y.

    1994-12-31

    The application of DNA fingerprinting has become very broad in forensic analysis, patient identification, diagnostic medicine, and wildlife poaching, since every individual`s DNA structure is identical within all tissues of their body. DNA fingerprinting was initiated by the use of restriction fragment length polymorphisms (RFLP). In 1987, Nakamura et al. found that a variable number of tandem repeats (VNTR) often occurred in the alleles. The probability of different individuals having the same number of tandem repeats in several different alleles is very low. Thus, the identification of VNTR from genomic DNA became a very reliable method for identification of individuals. DNA fingerprinting is a reliable tool for forensic analysis. In DNA fingerprinting, knowledge of the sequence of tandem repeats and restriction endonuclease sites can provide the basis for identification. The major steps for conventional DNA fingerprinting include (1) specimen processing (2) amplification of selected DNA segments by PCR, and (3) gel electrophoresis to do the final DNA analysis. In this work we propose to use laser desorption mass spectrometry for fast DNA fingerprinting. The process and advantages are discussed.

  15. Information on subsoil geological structure in the city of Catania (Eastern Sicily) from microtremor measurements

    Energy Technology Data Exchange (ETDEWEB)

    Giampiccolo, E.; Gresta, S.; De Guidi, G. [Catania Univ., Catania (Italy). Dipt. di Scienze Geologiche; Gallipoli, M. R. [Potenza Univ. della Basilicata, Potenza (Italy). Dipt. di Strutture, Geotecnica e Geologia Applicata; Mucciarelli, M. [Consiglio Nazionale delle Ricerche, Istituto di Metodologie Avanzate di Analisi Ambientale, Tito Scalo, PZ (Italy)

    2001-02-01

    Nakamura's technique, or the H/V spectral ratio method, has been applied to microtremor measurements carried out in the urban area of Catania (Eastern Sicily) to obtain information on the geological structure of some sites, and to make a hypothesis on their seismic response. In general, sites located on soft soils or anthropic debris fillings have shown greater amplification at high frequencies (above 1 Hz). However, a strong lateral variation was observed in the frequency band, thus a denser grid of measurement points is necessary for a precise mapping of the resonant frequencies. In the low frequency range, between 0.1 and 1 Hz, a common peak around 0.2 Hz was observed. The fundamental resonant frequency inferred from the main peak in the H/V spectrum has been used to calculate the depth of the interface between the clays and the main reflector on the basis of the shear-wave velocity: it has been estimated as about 700 m.

  16. Information on subsoil geological structure in the city of Catania (Eastern Sicily from microtremor measurements

    Directory of Open Access Journals (Sweden)

    M. R. Gallipoli

    2001-06-01

    Full Text Available Nakamura’s technique, or the H/V spectral ratio method, has been applied to microtremor measurements carried out in the urban area of Catania (Eastern Sicily to obtain information on the geological structure of some sites,and to make a hypothesis on their seismic response. In general, sites located on soft soils or anthropic debris fillings have shown greater amplification at high frequencies (above 1 Hz. However, a strong lateral variation was observed in the frequency band, thus a denser grid of measurement points is necessary for a precise mapping of the resonant frequencies. In the low frequency range, between 0.1 and 1 Hz, a common peak around 0.2 Hz was observed. The fundamental resonant frequency inferred from the main peak in the H/V spectrum has been used to calculate the depth of the interface between the clays and the main reflector on the basis of the shear-wave velocity: it has been estimated as about 700 m.

  17. Relationship between soft stratum thickness and predominant frequency of ground based on microtremor observation data

    Science.gov (United States)

    Chia, Kenny; Lau, Tze Liang

    2017-07-01

    Despite categorized as low seismicity group, until being affected by distant earthquake ground motion from Sumatra and the recent 2015 Sabah Earthquake, Malaysia has come to realize that seismic hazard in the country is real and has the potential to threaten the public safety and welfare. The major concern in this paper is to study the effect of local site condition, where it could amplify the magnitude of ground vibration at sites. The aim for this study is to correlate the thickness of soft stratum with the predominant frequency of soil. Single point microtremor measurements were carried out at 24 selected points where the site investigation reports are available. Predominant period and frequency at each site are determined by Nakamura's method. The predominant period varies from 0.22 s to 0.98 s. Generally, the predominant period increases when getting closer to the shoreline which has thicker sediments. As far as the thickness of the soft stratum could influence the amplification of seismic wave, the advancement of micotremor observation to predict the thickness of soft stratum (h) from predominant frequency (fr) is of the concern. Thus an empirical relationship h =54.917 fr-1.314 is developed based on the microtremor observation data. The empirical relationship will be benefited in the prediction of thickness of soft stratum based on microtremor observation for seismic design with minimal cost compared to conventional boring method.

  18. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach

    Science.gov (United States)

    Parwatiningtyas, Diyan; Ambarsari, Erlin Windia; Marlina, Dwi; Wiratomo, Yogi

    2014-03-01

    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area.

  19. Microtremor measurements at the University of Mississippi campus

    Science.gov (United States)

    Guo, Z.; Aydin, A.

    2011-12-01

    Microtremor measurements provide an efficient means of evaluating the site effect. Simple operation, speed and relatively low cost of this technique promoted its widespread use in research and engineering practice. The measurements of microtremor patterns were made at more than 40 points throughout the campus during several months. Generally, at each point, three recordings each with at least 1 hour duration were obtained. Additionally at three selected points, long term (continuous for 48 hours) measurements were made. H/V spectral ratio was calculated for each points to determine the predominate frequency based on which the site effect evaluation and classification were carried out. The correlation analysis of vertical, North-South and East-West spectra with weather conditions (especially wind speed and direction) were performed for each long-term measurement points. In conclusion, a site effect classification map of the campus was prepared and influence of weather changes on microtremor spectral properties was evaluated. Finn, L.W.D., 1991. Geotechnical Engineering Aspects of Microzonation, Fourth International Conference on Seismic Zonation, Stanford, California, USA, August 1991, 199-259. Nakamura, Y. (1989). A method for dynamic characteristics estimation of subsurface using microtremor on the ground surface, QR of RTRI 30, No. 1, February, 25-33. Sylvette Bonnefoy-Claudet, Stéphane Baize, Luis Fabian Bonilla, et al (2008), Site effect evaluation in the basin of Santiago de Chile using ambient noise measurements, Geophys. J. Int. 1-13.

  20. Disaster risk management in prospect mining area Blitar district, East Java, using microtremor analysis and ANP (analytical network processing) approach

    Energy Technology Data Exchange (ETDEWEB)

    Parwatiningtyas, Diyan, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com; Ambarsari, Erlin Windia, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com; Marlina, Dwi, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com; Wiratomo, Yogi, E-mail: diane.tyas@gmail.com, E-mail: erlinunindra@gmail.com [Department of Physics, Faculty of Engineering, Mathematics and Natural Sciences, Indraprasta PGRI University, Nangka Street No. 58C Tanjung Barat, South Jakarta (Indonesia)

    2014-03-24

    Indonesia has a wealth of natural assets is so large to be managed and utilized, either from its own local government and local communities, especially in the mining sector. However, mining activities can change the state of the surface layer of the earth that have a high impact disaster risk. This could threaten the safety and disrupt human life, environmental damage, loss of property, and the psychological impact, sulking to the rule of law no 24 of 2007. That's why we strive to manage and minimize the risk of mine disasters in the region, how to use the method of calculation of Amplification Factor (AF) from the analysis based microtremor sulking Kanai and Nakamura, and decision systems were tested by analysis of ANP. Based on the amplification factor and Analytical Network Processing (ANP) obtained, some points showed instability in the surface layer of a mining area include the site of the TP-7, TP-8, TP-9, TP-10, (Birowo2). If in terms of structure, location indicated unstable due to have a sloping surface layer, resulting in the occurrence of landslides and earthquake risk is high. In the meantime, other areas of the mine site can be said to be a stable area.

  1. Sensitivity Analysis of Pulsatile Hydromagnetic Biofluid Flow and Heat Transfer with Non Linear Darcy-Forchheimer Drag

    Directory of Open Access Journals (Sweden)

    S. Rawat

    2016-01-01

    Full Text Available In the present paper we examine the pulsatile hydromagnetic flow and heat transfer of a non-Newtonian biofluid through a saturated non-Darcian porous medium channel. The upper plate of the channel is heated and the lower plate is cooled. The Nakamura-Sawada rheological model is employed which provides a higher yield stress than the Casson model. A Darcy-Forchheimer porous medium drag force model is incorporated to simulate blood vessel blockage with deposits in the cardiovascular system. Viscous heating is also included in the energy equation. The governing conservation equations for mass, momentum and energy equation are transformed into a system of nonlinear, coupled ordinary differential equations and these are solved numerically using finite element method. The effect of other important parameters such as magnetohydrodynamic parameter (Nm, Reynolds number (Re, Eckert number (Ec, Darcian parameter (, Forchheimer parameter (NF and Prandtl number on velocity and temperature profiles are studied graphically. Spatial-temporal velocity and temperature profile visualizations are also presented. Numerical results shows that normalized fluid velocity (U increases throughout the channel (-1 < Y < 1 with an increase in Reynolds number, Darcian parameter, steady pressure gradient parameter and rheological parameter; conversely velocity is decreased with the increase in magnetic parameter and Forchheimer quadratic drag parameter. Higher Eckert number (Ec = 3 is also found to have a considerable effect on temperature ( profile. Finite difference numerical computations are also compared with the finite element solutions to verify efficiency and accuracy.

  2. Determinación de los periodos predominantes de los depósitos de suelo de Tunja y Sogamoso usando microtemblores

    Directory of Open Access Journals (Sweden)

    Orlando Rincón Arango

    2010-11-01

    Full Text Available En el estudio fueron evaluados los periodos de losdepósitos de suelo mediante la relación H/V, técnicade Nakamura aplicada a registros de microtemblores;los registros fueron realizados en puntos del área urbanapara las ciudades de Tunja y Sogamoso (Boyacá,Colombia; se incluyó el análisis de estabilidad horariaen suelo y roca para los sitios de instalación deestaciones acelerográficas, se elaboró un mapa deisoperiodos y se establecieron zonas de respuestadinámica similar, comparando los resultados con laszonificaciones previas realizadas y los accidentestopográficos. Además, se analizó la variabilidad de losregistros ante la presencia de tubificación subsuperficial,fenómeno habitual en la ciudad de Tunja, debido a losavanzados procesos de erosión de los depósitos, queha desestabilizado diversas construcciones. Losresultados obtenidos se usaron para determinar los sitiosdonde sería necesario instrumentar, y se trazaron pautaspara el proceso de zonificación definitivo de las ciudades,en la siguiente etapa del proyecto de microzonificación

  3. Bipolar disorder recurrence prevention using self-monitoring daily mood charts: case reports from a 5 year period

    Directory of Open Access Journals (Sweden)

    Yasui-Furukori N

    2017-03-01

    Full Text Available Norio Yasui-Furukori, Kazuhiko Nakamura Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan Abstract: Mood symptoms in bipolar disorders are significantly related to psychosocial events, and the personalized identification of symptom triggers is important. Ecological momentary assessments have been used in paper-and-pencil form to explore emotional reactivity to daily life stress in patients with bipolar disorder. However, there are few data on long-term recurrence prevention effects using ecological momentary assessments. Subjects were three outpatients with bipolar disorder who had a history of at least one admission. They recorded self-monitoring daily mood charts using a 5-point Likert scale. Paper-and-pencil mood charts included mood, motivation, thinking speed, and impulsivity. Additionally, they recorded waking time, bedtime, and medication compliance. Fewer manic or depressive episodes including admissions occurred after self-monitoring daily mood charts compared to patients’ admissions in the past 3 years. This study suggests that self-monitoring daily mood in addition to mood stabilizing medication has some effect on recurrence prevention in follow-up periods of at least 5 years. Further studies with rigorous designs and large sample sizes are needed. Keywords: bipolar disorders, recurrence, self-monitoring, ecological momentary assessments

  4. Gravitational collapse of charged scalar fields

    CERN Document Server

    Torres, Jose M

    2014-01-01

    In order to study the gravitational collapse of charged matter we analyze the simple model of an self-gravitating massless scalar field coupled to the electromagnetic field in spherical symmetry. The evolution equations for the Maxwell-Klein-Gordon sector are derived in the 3+1 formalism, and coupled to gravity by means of the stress-energy tensor of these fields. To solve consistently the full system we employ a generalized Baumgarte-Shapiro-Shibata-Nakamura (BSSN) formulation of General Relativity that is adapted to spherical symmetry. We consider two sets of initial data that represent a time symmetric spherical thick shell of charged scalar field, and differ by the fact that one set has zero global electrical charge while the other has non-zero global charge. For compact enough initial shells we find that the configuration doesn't disperse and approaches a final state corresponding to a sub-extremal Reissner-N\\"ordstrom black hole with $|Q|

  5. Constraint Trajectory Surface-Hopping Molecular Dynamics Simulation of the Photoisomerization of Stilbene

    Directory of Open Access Journals (Sweden)

    Yibo Lei

    2014-01-01

    Full Text Available Combining trajectory surface hopping (TSH method with constraint molecular dynamics, we have extended TSH method from full to flexible dimensional potential energy surfaces. Classical trajectories are carried out in Cartesian coordinates with constraints in internal coordinates, while nonadiabatic switching probabilities are calculated separately in free internal coordinates by Landau-Zener and Zhu-Nakamura formulas along the seam. Two-dimensional potential energy surfaces of ground S0 and excited S1 states are constructed analytically in terms of torsion angle and one dihedral angle around the central ethylenic C=C bond, and the other internal coordinates are all fixed at configuration of the conical intersection. At this conical intersection, the branching ratio from the present simulation is 48 : 52 (33 : 67 initially starting from trans(cis-Stilbene in comparison with experimental value 50 : 50. Quantum yield for trans-to-cis isomerization is estimated as 49% in very good agreement with experimental value of 55%, while quantum yield for cis-to-trans isomerization is estimated as 47% in comparison with experimental value of 35%.

  6. Frustrated quantum-spin system on a triangle coupled with e{sub g} lattice vibrations: correspondence to Longuet-Higgins et al' s Jahn-Teller model

    Energy Technology Data Exchange (ETDEWEB)

    Yamasaki, Hisatsugu [Department of Applied Physics, Osaka City University, Osaka 558-8585 (Japan); Natsume, Yuhei [Graduate School of Science and Technology, Chiba University, Chiba 263-8522 (Japan); Terai, Akira [Department of Applied Physics, Osaka City University, Osaka 558-8585 (Japan); Nakamura, Katsuhiro [Department of Applied Physics, Osaka City University, Osaka 558-8585 (Japan)

    2004-09-01

    We investigate the frustrated quantum three-spin model (S{sub 1},S{sub 2},S{sub 3}) of spin = 1/2 on a triangle, in which spins are coupled with lattice-vibrational modes through the antiferromagnetic exchange interaction depending on distances between spin sites. The present model corresponds to the dynamic Jahn-Teller system E{sub g} - e{sub g} proposed by Longuet-Higgins et al (1958 Proc. R. Soc. A 244 1). This correspondence is revealed by using the transformation to Nakamura-Bishop's bases used in Phys. Rev. Lett. 54 861 (1985). Furthermore, we elucidate the relationship between a chiral order parameter {chi}-circumflex = S{sub 1}{center_dot}(S{sub 2}xS{sub 3}) in the spin system and the electronic orbital angular momentum l-circumflex{sub z} in E{sub g} - e{sub g} vibronic model: the regular oscillatory behaviour of the expectation value <{chi}-circumflex> with increasing energy can be found as in the case of for vibronic structures. The increase of the additional anharmonicity(chaoticity) is found to yield a rapidly decaying irregular oscillation of <{chi}-circumflex>. (letter to the editor)

  7. Study on the applicability of frequency spectrum of micro-tremor and dynamic characteristics of surface ground in Asia area

    Institute of Scientific and Technical Information of China (English)

    CHE Ai-lan; IWATATE Takahiro; ODA Yoshiya; GE Xiu-run

    2006-01-01

    The dynamic characteristics of ground soil using micro-tremor observation in Asia (Zushi and Ogasawara (Japan),Xi'an (China), Manila (Philippines), and Gujarat (India)) are studied. Ground micro-tremor signals were observed and analyzed by fast Fourier transform method (FFT). The response of ground soil to frequency of ground micro-tremor is revealed, and functions with frequency-dependence and frequency-selection of micro-tremor for different foundation soil strata are also researched.The horizontal to vertical spectral ratio (H/V, Nakamura technique) of micro-tremor observed at the surface ground was used to evaluate the site's predominant period. This paper also discusses the application of micro-tremor on site safety evaluation, and gives the observed calculation results obtained at multiple points. The experimental foundation and the deduction process of the method are described in detail. Some problems of the method are pointed out. Potential use of the technique's good expandable nature makes it a useable means for preventing and reducing disaster's harmful effects.

  8. Mineralogy of Stardust Track 112 Particle: Relation to Amoeboid Olivine Aggregates

    Science.gov (United States)

    Komatsu, M.; Fagan, T.; Mikouchi, T.; Miyamoto, M.; Zolensky, M.; Ohsumi, K.

    2012-01-01

    The successful analysis of comet 81P/Wild 2 particles returned by the Stardust mission has revealed that the Wild 2 dust contains abundant silicate grains that are much larger than interstellar grains and appear to have formed in the inner regions of the solar nebula [1]. Wild 2 particles include minerals which are isotopically and mineralogically similar to CAIs [e.g., 2, 3] and chondrules [e.g., 4] in chondrites. In addition, particles similar to amoeboid olivine aggregates (AOAs) also have been discovered [5, 6,7]. C2067,2,112,1 is a terminal particle recovered from track #112 (T112). Nakamura-Messenger et al. [7] showed that the forsterite grain in T112 has O-16 enrichment of approximately 40 0/00 (vs. SMOW) and possibly formed together with AOAs. In this study, we have examined the mineralogy of the T112 particle and compared the possible relationships between T112 and AOAs in primitive meteorites.

  9. A successful case of dose reduction in etizolam dependence using fine granules: a case report

    Directory of Open Access Journals (Sweden)

    Nishii S

    2014-08-01

    Full Text Available Shigeki Nishii,1 Hikaru Hori,1 Toshifumi Kishimoto,2 Jun Nakamura1 1Department of Psychiatry, University of Occupational and Environmental Health, Yahatanishi-ku, Kitakyushu, Fukuoka, Japan; 2Department of Psychiatry, Nara Medical University, Shijocho, Kashihara, Nara, Japan Abstract: The prevalence of benzodiazepine consumption in Japan is one of the highest worldwide. Etizolam is the most abused drug of the benzodiazepine class. The treatment of benzodiazepine dependence is difficult. We report a case of successful dosage reduction in a 24-year-old female patient with etizolam dependence. She was diagnosed with etizolam dependence at the age of 22 years old. We proposed a benzodiazepine dependence treatment that involved replacing etizolam with a long-acting benzodiazepine class drug in conjunction with a long-term weaning plan. However, the patient refused the treatment and insisted that reducing the number of tablets would increase her anxiety. After providing a detailed explanation and receiving consent from the patient, a treatment regimen consisting of fine granules of etizolam mixed with lactose granules was begun with the aim of reducing the percentage of etizolam at a rate of 0.3 mg/week. The treatment of etizolam dependence in this patient was successful. This treatment strategy may be an effective option for patients who are difficult to treat with conventional methods, or who have anxiety regarding the reduction of the amount of the drug itself. Keywords: benzodiazepine, Japan, dependence, etizolam

  10. Effect of Soil Texture on Starch Accumulation and Activities of Key Enzymes of Starch Synthesis in the Kernel of ZM 9023

    Institute of Scientific and Technical Information of China (English)

    WANG Wen-jing; ZHAN Hai-hong

    2008-01-01

    Three kinds of soil texture (clay-loam, mid-loam, and sand-loam soil) were used to study the effects of soil texture on starch accumulating rate and the changes in activities of the key enzymes of starch synthesis in the kernel during grain filling in high gluten content wheat ZM 9023, under conditions of pond culture. The content of starch and its components were measured according to the method of double-wave length described by Bao (1996). ADP-glucose pyrophosphorylase (AGPP) activity was tested according to the method described by Doehlert et al. (1988). Soluble starch synthase (SSS) and starch branching enzyme (SBE) activities were tested according to the method described by Nakamura et al. (1989). The amylose, amylopectin, and total starch accumulating rate in the kernel of ZM 9023 were found to be a single-peak curve in three different soil textures during grain filling, and peaked 20, 15, and 15 d after anthesis, respectively. The activities of the enzymes, AGPP, SSS, and SBE, in the kernel of ZM 9023 had a single-peaked curve, which peaked 20, 15, and 15 d after anthesis, respectively. The activities of the above three enzymes of ZM 9023 were higher in the sand-loam soil. The accumulating peak of amylose formed later compared to that of amylopectin. The sand-loam soil could help high gluten content cultivars to synthesize starch.

  11. Zoom & Whirl Eccentric equatorial orbits around spinning black holes and their evolution under gravitational radiation reaction

    CERN Document Server

    Glampedakis, K; Glampedakis, Kostas; Kennefick, Daniel

    2002-01-01

    We study eccentric equatorial orbits of a test-body around a Kerr black hole under the influence of gravitational radiation reaction. We have adopted a well established two-step approach: assuming that the particle is moving along a geodesic (justifiable as long as the orbital evolution is adiabatic) we calculate numerically the fluxes of energy and angular momentum radiated to infinity and to the black hole horizon, via the Teukolsky-Sasaki-Nakamura formalism. We can then infer the rate of change of orbital energy and angular momentum and thus the evolution of the orbit. The orbits are fully described by a semi-latus rectum $p$ and an eccentricity $e$. We find that while, during the inspiral, $e$ decreases until shortly before the orbit reaches the separatrix of stable bound orbits (which is defined by $p_{s}(e)$), in many astrophysically relevant cases the eccentricity will still be significant in the last stages of the inspiral. In addition, when a critical value $p_{crit}(e)$ is reached, the eccentricity ...

  12. Lupus I Observations from the 2010 Flight of the Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry

    Science.gov (United States)

    Matthews, Tristan G.; Ade, Peter A. R.; Angilè, Francesco E.; Benton, Steven J.; Chapin, Edward L.; Chapman, Nicholas L.; Devlin, Mark J.; Fissel, Laura M.; Fukui, Yasuo; Gandilo, Natalie N.; Gundersen, Joshua O.; Hargrave, Peter C.; Klein, Jeffrey; Korotkov, Andrei L.; Moncelsi, Lorenzo; Mroczkowski, Tony K.; Netterfield, Calvin B.; Novak, Giles; Nutter, David; Olmi, Luca; Pascale, Enzo; Poidevin, Frédérick; Savini, Giorgio; Scott, Douglas; Shariff, Jamil A.; Soler, Juan Diego; Tachihara, Kengo; Thomas, Nicholas E.; Truch, Matthew D. P.; Tucker, Carole E.; Tucker, Gregory S.; Ward-Thompson, Derek

    2014-04-01

    The Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry (BLASTPol) was created by adding polarimetric capability to the BLAST experiment that was flown in 2003, 2005, and 2006. BLASTPol inherited BLAST's 1.8 m primary and its Herschel/SPIRE heritage focal plane that allows simultaneous observation at 250, 350, and 500 μm. We flew BLASTPol in 2010 and again in 2012. Both were long duration Antarctic flights. Here we present polarimetry of the nearby filamentary dark cloud Lupus I obtained during the 2010 flight. Despite limitations imposed by the effects of a damaged optical component, we were able to clearly detect submillimeter polarization on degree scales. We compare the resulting BLASTPol magnetic field map with a similar map made via optical polarimetry. (The optical data were published in 1998 by J. Rizzo and collaborators.) The two maps partially overlap and are reasonably consistent with one another. We compare these magnetic field maps to the orientations of filaments in Lupus I, and we find that the dominant filament in the cloud is approximately perpendicular to the large-scale field, while secondary filaments appear to run parallel to the magnetic fields in their vicinities. This is similar to what is observed in Serpens South via near-IR polarimetry, and consistent with what is seen in MHD simulations by F. Nakamura and Z. Li.

  13. Strontium isotopic ages of the Torinosu-type limestones (latest Jurassic to earliest Cretaceous, Japan): Implication for biocalcification event in northwestern Palaeo-Pacific

    Science.gov (United States)

    Kakizaki, Yoshihiro; Ishikawa, Tsuyoshi; Nagaishi, Kazuya; Tanimizu, Masaharu; Hasegawa, Takashi; Kano, Akihiro

    2012-03-01

    The ages of the Late Jurassic to the Early Cretaceous shallow marine limestones in Japan (the Torinosu-type limestones) were evaluated by Sr isotopic stratigraphy. The 87Sr/86Sr ratios of 17 brachiopods collected from three sections revealed ages that are consistent with the previous assumption based on biostratigraphy. The age of the upper horizon of the Koike Limestone Member (the Soma-Nakamura Group, NE Japan) ranges from 150.6 Ma to 149.2 Ma (the latest Kimmeridgian to the early Tithonian). The limestones from two sections (the Torinosu and Imaidani Group) on Shikoku Island of SW Japan yield the younger ages, which evaluate the depositional rate of the two limestones 6.3-14.5 m/m.y. By applying these rates, the depositional period was estimated for the whole limestone of each section; from 151.1 Ma (the latest Kimmeridgian) to 140.3 Ma (the latest Berriasian) for the Torinosu Group, from 151.5 Ma (the late Kimmeridgian) to 143.0 Ma (the early Berriasian) for the Imaidani Group. These results confirm active carbonate deposition in the shallow fore-arc platform in SW Japan from the Tithonian to the Berriasian. The biocalcification event recognized in relevant age in the Tethyan region was likely expanded to the Palaeo-Pacific. The carbonate deposition in the platform was terminated by sea level fall during the early Valanginian.

  14. Computational solutions for non-isothermal, nonlinear magneto-convection in porous media with hall/ionslip currents and ohmic dissipation

    Directory of Open Access Journals (Sweden)

    O. Anwar Bég

    2016-03-01

    Full Text Available A theoretical and numerical study is presented to analyze the nonlinear, non-isothermal, magnetohydrodynamic (MHD free convection boundary layer flow and heat transfer in a non-Darcian, isotropic, homogenous porous medium, in the presence of Hall currents, Ionslip currents, viscous heating and Joule heating. A power-law variation is used for the temperature at the wall. The governing nonlinear coupled partial differential equations for momentum conservation in the x and z directions and heat conservation, in the flow regime are transformed from an (x, y, z coordinate system to a (ξ,η coordinate system in terms of dimensionless x-direction velocity (∂F/∂η and z-direction velocity (G and dimensionless temperature function (H under appropriate boundary conditions. Both Darcian and Forchheimer porous impedances are incorporated in both momentum equations. Computations are also provided for the variation of the x and z direction shear stress components and also local Nusselt number. Excellent correlation is achieved with a Nakamura tridiagonal finite difference scheme (NTM. The model finds applications in magnetic materials processing, MHD power generators and purification of crude oils.

  15. Scattering and Absorption of Gravitational Plane Waves by Rotating Black Holes

    CERN Document Server

    Dolan, Sam R

    2008-01-01

    In this study, we investigate scattering and absorption of planar gravitational waves by a Kerr black hole in vacuum. We compute cross sections for radiation incident along the rotation axis, and consider both co- and counter-rotating circular polarizations. We show that, if a novel series reduction method is employed, the partial wave approach developed by Matzner and coworkers yields accurate results. Phase shifts are computed via a Sasaki-Nakamura transformation, and spheroidal harmonics via a spectral decomposition method. A catalogue of cross sections is presented for a range of parameters ($M\\omega \\le 4$ and $a \\le 0.99M$). In the long- and short-wavelength regimes we find good agreement with perturbative and semi-classical approximations. We confirm that helicity is not conserved: flux scattered in the backward direction has the opposite polarization to the incident radiation. At low frequencies, fast-rotating holes generate superradiance in the $l = 2$, $m = 2$ mode which enhances the back-scattered ...

  16. HIGH-EFFICIENCY NITRIDE-BASED SOLID-STATE LIGHTING

    Energy Technology Data Exchange (ETDEWEB)

    Paul T. Fini; Shuji Nakamura

    2003-10-30

    In this second annual report we summarize the progress in the second-year period of Department of Energy contract DE-FC26-01NT41203, entitled ''High- Efficiency Nitride-Based Solid-State Lighting''. The two teams, from the University of California at Santa Barbara (Principle Investigator: Dr. Shuji Nakamura) and Rensselaer Polytechnic Institute (led by Dr. N. Narendran), are pursuing the goals of this contract from thin film growth, characterization, and packaging standpoints. The UCSB team has recently made significant progress in the development of light-emitting diodes (LEDs) with AlGaN active regions emitting in the ultraviolet (UV), resonant-cavity LEDs (RCLEDs), as well as lateral epitaxial overgrowth (LEO) techniques to obtain large-area non-polar GaN films with low average dislocation density. The Rensselaer team has benchmarked the performance of commercially available LED systems and has also conducted efforts to develop an optimized RCLED packaging scheme, including development of advanced epoxy encapsulant chemistries.

  17. Nonadiabatic ab initio molecular dynamics study of photoisomerization in N-salicilydenemethylfurylamine (SMFA)

    Science.gov (United States)

    Gao, Ai-Hua; Wang, Mei-Shan

    2017-03-01

    The photoisomerization mechanisms of N-salicilydenemethylfurylamine upon excitation to the first singlet state are investigated by means of surface-hopping dynamics simulations based on the Zhu-Nakamura theory. Due to different orientations of the methyl-furyl part with respect to the salicylaldimine part and different orientations of hydroxy group with respect to the benzene ring, various stable structures are obtained in the optimization. The enol isomer, S0-ENOL-5a, is the most stable conformer. An ultrafast excited-state intramolecular proton transfer is observed after photoexcitation of the most stable enol conformer and then the molecule reaches the excited-state minimum. After the internal conversion around a conical intersection, the system relaxes to either the cis-keto or trans-keto region in the ground state. The potential energy profiles of the ground and the first excited singlet state are also calculated. According to full-dimensional nonadiabatic dynamics simulations and potential energy profiles, the trans-keto and cis-keto photoproducts can be responsible for the photochromic effect of N-salicilydenemethylfurylamine.

  18. Note to Energy Source of Tsunami Earthquake on the Planet Earth

    Science.gov (United States)

    Nakamura, S.

    2012-04-01

    Note to Energy Source of Tsunami Earthquake on the Planet Earth Shigehisa Nakamura Kyoto University, Japan This note concerns to an energyy source of tsunami earthquake. In the case of the earthquake on 11 March 2011, a satellite monitoring by the Geographic Survey Institute informed some spcific pattern of the earth surface displacements just around tothe epicenter of the interested earthquake. The monitoring pattern shows that the pattern of the earth surface displacements must be understood well when the earth surface as a part of the spherical earth crusts with a physical property of a visco-plastic material rather than with a solid plate consisted by rigid material made by the products of the magma in the planet earth. This means that the pattern was appared in a short time of only several minutes, say, two or three munutes after the seismic shock was happened. The pattern of the displacement shows as if it was for a pattern of a visco-plastic fluid flowing to the pit hole force for the at the epicenter out of a conduit of the magma in order to return to the mother magma flow under the spherical crust of the planet earth. This pattern is raising us to find an updateddd model after an advanced reserarch as soon as possible in order to realize what should be a reasonable energy source to see the tsunami earthquake.

  19. Stemcell Information: SKIP000221 [SKIP Stemcell Database[Archive

    Lifescience Database Archive (English)

    Full Text Available N-2A HPS0009 HPS0009 ... -- Male ... -- No Human iPS cell line. ヒトiPS細胞。臍帯由来線維芽細胞(RCB0197 HUC-Fm)由来。 ... SKIP000221 ... Umbilical cord(Fibroblast) 臍帯(線維芽細胞) Normal HiPS-RIKEN-2A HiPS-RIKE...human ES-like -- Retrovirus Retroviral vector pMXs, Oct3/4, Sox2, Klf4, c-Myc ... Yes MEF (X-rays:5000R or MMC) 1-1.5x10^(6) cell.../www2.brc.riken.jp/lab/cell/detail.cgi?cell_no=HPS0009&type=1 ... ...学研究所バイオリソースセンター RIKEN BRC 理化学研究所バイオリソースセンター Yukio Nakamura 中村幸夫 Available RIKEN BRC 理化学研究所バイオリソースセンター http:/

  20. Constraint-preserving boundary conditions in the 3+1 first-order approach

    Science.gov (United States)

    Bona, C.; Bona-Casas, C.

    2010-09-01

    A set of energy-momentum constraint-preserving boundary conditions is proposed for the first-order Z4 case. The stability of a simple numerical implementation is tested in the linear regime (robust stability test), both with the standard corner and vertex treatment and with a modified finite-differences stencil for boundary points which avoids corners and vertices even in Cartesian-like grids. Moreover, the proposed boundary conditions are tested in a strong-field scenario, the Gowdy waves metric, showing the expected rate of convergence. The accumulated amount of energy-momentum constraint violations is similar or even smaller than the one generated by either periodic or reflection conditions, which are exact in the Gowdy waves case. As a side theoretical result, a new symmetrizer is explicitly given, which extends the parametric domain of symmetric hyperbolicity for the Z4 formalism. The application of these results to first-order Baumgarte-Shapiro-Shibata-Nakamura-like formalisms is also considered.

  1. Adding metoclopramide to paroxetine induced extrapyramidal symptoms and hyperprolactinemia in a depressed woman: a case report

    Directory of Open Access Journals (Sweden)

    Igata R

    2016-09-01

    Full Text Available Ryohei Igata, Hikaru Hori, Kiyokazu Atake, Asuka Katsuki, Jun Nakamura Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Japan Abstract: A 54-year-old Japanese woman was diagnosed with major depressive disorder and prescribed paroxetine 20 mg/day. In around May 2013, the patient experienced gastric discomfort, so metoclopramide was prescribed. Beginning on June 4, 2013, the patient was given metoclopramide, 10 mg intravenously, twice per week. On the seventh day after beginning metoclopramide, facial hot flushes, increased sweating, muscle rigidity, and galactorrhea were noted. Extrapyramidal symptoms (EPS rapidly subsided in response to an intramuscular injection of biperiden. Blood biochemical tests revealed an elevated serum prolactin level of 44 ng/mL. After stopping metoclopramide, EPS disappeared. Serum prolactin level decreased to 15 ng/mL after 4 weeks. In our case, although no adverse reactions had previously occurred following the administration of metoclopramide, the patient developed EPS and hyperprolactinemia following the administration of this antiemetic in combination with paroxetine. Paroxetine and metoclopramide are mainly metabolized by CYP2D6, and they are inhibitors for CYP2D6. We report a case with EPS and hyperprolactinemia whose plasma paroxetine and metoclopramide level rapidly increased after the addition of metoclopramide. Our experience warrants the issuing of a precaution that adverse reactions may arise following the coadministration of metoclopramide and paroxetine even at their respective standard dose levels. Keywords: metoclopramide, paroxetine, extrapyramidal symptoms, SSRI, hyperprolactinemia, depression

  2. Laser mass spectrometry for DNA fingerprinting for forensic applications

    Science.gov (United States)

    Chen, C. H. Winston; Tang, Kai; Taranenko, N. I.; Allman, S. L.; Ch'ang, L. Y.

    1994-10-01

    The application of DNA fingerprinting has become very broad in forensic analysis, patient identification, diagnostic medicine, and wildlife poaching, since every individual's DNA structure is identical within all tissues oftheir body. DNA fingerprinting was initiated by the use of restriction fragment length polymorphisms (RFLP). In 1987, Nakamura et aL2 found that a variable number of tandem repeats (VNTR) often occurred in the alleles. The probability of different individuals having the same number of tandem repeats in several different alleles is very low. Thus, the identification of VNTR from genomic DNA became a very reliable method for identification of individuals. Take the Huntington gene as an example, there are CAG trinucleotide repeats. For normal people, the number of CAG repeats is usually between 10 and 40. Since people have chromosomes in pairs, the possibility oftwo individuals having the same VNTR in the Huntington gene is less than one percent, ifwe assume equal distribution for various repeats. When several allels containing VNTR are analyzed for the number of repeats, the possibility of two individuals being exactly identical becomes very unlikely. Thus, DNA fingerprinting is a reliable tool for forensic analysis. In DNA fingerprinting, knowledge of the sequence of tandem repeats and restriction endornuclease sites can provide the basis for identification.

  3. Gravitational Radiation from the radial infall of highly relativistic point particles into Kerr black holes

    CERN Document Server

    Cardoso, V; Cardoso, Vitor; Lemos, Jos\\'e P. S.

    2003-01-01

    In this paper, we consider the gravitational radiation generated by the collision of highly relativistic particles with rotating Kerr black holes. We use the Sasaki-Nakamura formalism to compute the waveform, energy spectra and total energy radiated during this process. We show that the gravitational spectrum for high-energy collisions has definite characteristic universal features, which are independent of the spin of the colliding objects. We also discuss possible connections between these results and the black hole-black hole collision at the speed of light process. With these results at hand, we predict that during the high speed collision of a non-rotating hole with a rotating one, about 35% of the total energy gets converted into gravitational waves. Thus, if one is able to produce black holes at the Large Hadron Collider, 35% of the partons' energy should be emitted during the so called balding phase. This energy will be missing, since we don't have gravitational wave detectors able to measure such amp...

  4. Application of particle-mesh Ewald summation to ONIOM theory

    Science.gov (United States)

    Kobayashi, Osamu; Nanbu, Shinkoh

    2015-11-01

    We extended a particle mesh Ewald (PME) summation method to the ONIOM (our Own N-layered Integrated molecular Orbitals and molecular Mechanics) scheme (PME-ONIOM) to validate the simulation in solution. This took the form of a nonadiabatic ab initio molecular dynamics (MD) simulation in which the Zhu-Nakamura trajectory surface hopping (ZN-TSH) method was performed for the photoisomerization of a (Z)-penta-2,4-dieniminium cation (protonated Schiff base, PSB3) electronically excited to the S1 state in a methanol solution. We also calculated a nonadiabatic ab initio MD simulation with only minimum image convention (MI-ONIOM). The lifetime determined by PME-ONIOM-MD was 3.483 ps. The MI-ONIOM-MD lifetime of 0.4642 ps was much shorter than those of PME-ONIOM-MD and the experimentally determined excited state lifetime. The difference eminently illustrated the accurate treatment of the long-range solvation effect, which destines the electronically excited PSB3 for staying in S1 at the pico-second or the femto-second time scale.

  5. Numerical relativity for D dimensional axially symmetric space-times: formalism and code tests

    CERN Document Server

    Zilhao, Miguel; Sperhake, Ulrich; Cardoso, Vitor; Gualtieri, Leonardo; Herdeiro, Carlos; Nerozzi, Andrea

    2010-01-01

    The numerical evolution of Einstein's field equations in a generic background has the potential to answer a variety of important questions in physics: from applications to the gauge-gravity duality, to modelling black hole production in TeV gravity scenarios, analysis of the stability of exact solutions and tests of Cosmic Censorship. In order to investigate these questions, we extend numerical relativity to more general space-times than those investigated hitherto, by developing a framework to study the numerical evolution of D dimensional vacuum space-times with an SO(D-2) isometry group for D\\ge 5, or SO(D-3) for D\\ge 6. Performing a dimensional reduction on a (D-4)-sphere, the D dimensional vacuum Einstein equations are rewritten as a 3+1 dimensional system with source terms, and presented in the Baumgarte, Shapiro, Shibata and Nakamura (BSSN) formulation. This allows the use of existing 3+1 dimensional numerical codes with small adaptations. Brill-Lindquist initial data are constructed in D dimensions an...

  6. Nonadiabatic ab initio molecular dynamics with PME-ONIOM scheme of photoisomerization reaction between 1,3-cyclohexadiene and 1,3,5-cis-hexatriene in solution phase

    Science.gov (United States)

    Ohta, Ayumi; Kobayashi, Osamu; Danielache, Sebastian O.; Nanbu, Shinkoh

    2017-03-01

    The ultra-fast photoisomerization reactions between 1,3-cyclohexadiene (CHD) and 1,3,5-cis-hexatriene (HT) in both hexane and ethanol solvents were revealed by nonadiabatic ab initio molecular dynamics (AI-MD) with a particle-mesh Ewald summation method and our Own N-layered Integrated molecular Orbital and molecular Mechanics model (PME-ONIOM) scheme. Zhu-Nakamura version trajectory surface hopping method (ZN-TSH) was employed to treat the ultra-fast nonadiabatic decaying process. The results for hexane and ethanol simulations reasonably agree with experimental data. The high nonpolar-nonpolar affinity between CHD and the solvent was observed in hexane solvent, which definitely affected the excited state lifetimes, the product branching ratio of CHD:HT, and solute (CHD) dynamics. In ethanol solvent, however, the CHD solute was isomerized in the solvent cage caused by the first solvation shell. The photochemical dynamics in ethanol solvent results in the similar property to the process appeared in vacuo (isolated CHD dynamics).

  7. Convective heat transfer over a wall mounted cube at different angle of attack using large eddy simulation

    Directory of Open Access Journals (Sweden)

    Heidarzadeh Habibollah

    2014-01-01

    Full Text Available Turbulent fluid flow and convective heat transfer over the wall mounted cube in different flow angle of attack have been studied numerically using Large Eddy Simulation. Cube faces and plate have a constant heat flux. Dynamic Smagorinsky (DS subgrid scale model were used in this study. Angles were in the range 0≤θ≤45 and Reynolds number based on the cube height and free stream velocity was 4200. The numerical simulation results were compared with the experimental data of Nakamura et al [6, 7]. Characteristics of fluid flow field and heat transfer compared for four angles of attack. Flow around the cube was classified to four regimes. Results was represented in the form of time averaged normalized streamwise velocity and Reynolds stress in different positions, temperature contours, local and average Nusselt number over the faces of cube. Local convective heat transfer on cube faces was affected by flow pattern around the cube. The local convective heat transfer from the faces of the cube and plate are directly related to the complex phenomena such as horse shoe vortex, arch vortexes in behind the cube, separation and reattachment. Results show that overall convective heat transfer of cube and mean drag coefficient have maximum and minimum value at θ=0 deg and θ=25 deg respectively.

  8. Pharmacokinetics of sevoflurane uptake into the brain.

    Science.gov (United States)

    Turner, M J; McCulloch, T J; Kennedy, R R; Baker, A B

    2004-12-01

    Two recent studies have examined the pharmacokinetics of sevoflurane in adults. Lu et al.(Pharmacokinetics of sevoflurane uptake into the brain and body, Anaesthesia 2003; 58: 951-6) observed that jugular bulb sevoflurane concentration initially rose unexpectedly rapidly and then approached arterial concentrations unexpectedly slowly, suggesting that a blood-brain diffusion barrier exists. They also observed a large alveolar-arterial sevoflurane gradient, suggesting that an alveolar-arterial diffusion barrier exists. Nakamura et al. (Predicted sevoflurane partial pressure in the brain with an uptake and distribution model: Comparison with the measured value in internal jugular vein blood. Journal of Clinical Monitoring and Computing 1999; 15: 299-305) found no diffusion barriers. We used a computer model to analyse both data sets and show that the observations of Lu et al. can be explained by contamination of jugular samples with extracerebral blood. It is possible that the alveolar-arterial gradients observed by Lu et al. are due to discrepancies in conversions between blood concentrations and gas partial pressures. Our study suggests that there is no blood-brain diffusion barrier for sevoflurane and that the data of Lu et al. must be interpreted with caution.

  9. Hyperprolactinemia during antipsychotics treatment increases the level of coagulation markers

    Directory of Open Access Journals (Sweden)

    Ishioka M

    2015-02-01

    Full Text Available Masamichi Ishioka, Norio Yasui-Furukori, Norio Sugawara, Hanako Furukori, Shuhei Kudo, Kazuhiko Nakamura Department of Neuropsychiatry, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan Objective: The strong association between psychiatric patients who receive antipsychotics and the incidence of venous thromboembolism (VTE is known. Although previous reports suggest that hyperprolactinemia often increases markers of activated coagulation, few studies have examined the direct relationship between the prolactin level elevated by antipsychotics and activated markers of activated coagulation.Method: The participants included 182 patients with schizophrenia (male =89, female =93 who received antipsychotic treatments for at least 3 months. Markers of VTE (D-dimer, fibrin/fibrinogen degradation products, and thrombin–antithrombin complex and serum prolactin concentrations were measured.Results: Prolactin levels were significantly correlated with the logarithmic transformation of the D-dimer (r=0.320, P=0.002 and fibrin/fibrinogen degradation product levels (r=0.236, P=0.026 but not of the thrombin–antithrombin complex level (r=0.117, ns among men. However, no correlations were found between the VTE markers and prolactin levels among women. These results were confirmed using multiple regression analyses that included demographic factors and antipsychotic dosages. Conclusion: The current study indicates that hyperprolactinemia is associated with an increase in markers of activated coagulation among men receiving antipsychotics. This finding clinically implies that monitoring and modulating prolactin levels among men are important to decrease the risk of VTE. Keywords: prolactin, antipsychotics, venous thromboembolism

  10. Revision of the family Sphyriocephalidae Pintner, 1913 (Cestoda: Trypanorhyncha), with the description of Heterosphyriocephalus encarnae n. sp. and redescriptions of two species of Sphyriocephalus.

    Science.gov (United States)

    Dallarés, Sara; Carrassón, Maite; Schaeffner, Bjoern C

    2017-02-01

    The family Sphyriocephalidae Pintner, 1913, which comprises the genera Hepatoxylon Bosc, 1811, Sphyriocephalus Pintner, 1913 and Heterosphyriocephalus Palm, 2004, is revised from newly-collected and museum material. Heterosphyriocephalus encarnae n. sp. is described from the pelagic thresher, Alopias pelagicus Nakamura (Lamniformes: Alopiidae) collected from the Pacific Ocean off Boca del Alamo, Mexico. This species can be readily distinguished from the rest of sphyriocephalids by its small size, low number of proglottids and long velum with a characteristically irregular and folded border, among other features. The tentacles show a distinctive basal armature, and a heteroacanthous typical metabasal armature with heteromorphous hooks. Redescriptions are provided for Sphyriocephalus tergestinus Pintner, 1913 and S. viridis (Wagener, 1854) Pintner 1913 based on novel morphological data. A phylogenetic analysis including the available sequences of sphyriocephalid species plus new generated sequences of S. tergestinus has been performed, from which S. tergestinus is allocated into Heterosphyriocephalus as H. tergestinus n. comb. New dichotomous keys for the determination of genera of Sphyriocephalidae are provided, as well as new generic diagnoses for Sphyriocephalus and Heterosphyriocephalus and keys for the determination of species within both genera. Although the morphology of the genus Hepatoxylon is not addressed in the present study, the available sequence of the type-species has been incorporated in the phylogenetic analysis and its relationship to the other two genera of the family is discussed. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

  11. Observations and Interpretation of Descent and Mixing in the Northern Hemisphere Brewer Dobson Circulation

    Science.gov (United States)

    Gille, J. C.; Karol, S.; Kinnison, D. E.; Yudin, V.; Nardi, B.

    2012-12-01

    In 1929 Brewer proposed that the motions now known as the Brewer-Dobson (BD) circulation were responsible for the observed high values of ozone at high latitudes, far from their low-latitude region of formation. Here data from the High Resolution Dynamics Limb Sounder (HIRDLS) instrument, with 1 km vertical resolution and 100 km along track spacing, are used examine how this circulation creates that distribution and its seasonal variation through the interactions between the overturning motions of the BD circulation and isentropic mixing in the lower and lowermost stratosphere (350-450K). Isopleths of ozone in equivalent latitude-potential temperature coordinates illustrate the high-latitude descent, controlled by diabatic cooling, from September to the lowest altitudes in January and February. This descent creates large gradients along isentropic surfaces, where mixing above ~ 360K is weak at this time. The strength of mixing is taken to be the effective diffusivity Deff as formulated by Nakamura [1996]. By late winter into spring the BD circulation weakens, as does the transport barrier near 35° associated with the sub-tropical jet. These processes allow strong equator-ward mixing, leading to progressively smaller latitudinal ozone gradients on the isentropes, and the rising and flattening of the ozone isopleths. By the end of the summer the isopleths show only small slopes, preparatory for the next cycle. These results for the ozone dynamics are similar, but not identical, to those obtained with NCAR's Whole Atmosphere Community Climate Model (WACCM) Version 4.

  12. Functional specificity of amino acid at position 246 in the tRNA mimicry domain of bacterial release factor 2.

    Science.gov (United States)

    Uno, M; Ito, K; Nakamura, Y

    1996-01-01

    The termination of protein synthesis in bacteria requires codon-specific polypeptide release factors RF-1 (UAG/UAA specific) and RF-2 (UGA/UAA specific). We have proposed that release factors mimic tRNA and recognize the stop codon for polypeptide release (Nakamura et al (1996) Cell 87, 147-150). In contrast to the textbook view, genetic experiments have indicated that Escherichia coli RF-2 terminates translation very weakly at UAA while Salmonella RF-2 decodes this signal efficiently. Moreover, an excess of E coli RF-2 was toxic to cells while an excess of Salmonella RF-2 was not. These two RF-2 proteins are identical except for 16 out of 365 amino acids. Fragment swap experiments and site-directed mutagenesis revealed that a residue at position 246 is solely responsible for these two phenotypes. Upon substituting Ala (equivalent to Salmonella RF-2) for Thr-246 of E coli RF-2, the protein acquired increased release activity for UAA as well as for UGA. These results led us to conclude that E coli RF-2 activity is potentially weak and that the amino acid at position 246 plays a crucial role, not for codon discrimination, but for stop codon recognition or polypeptide release, presumably constituting an essential moiety of tRNA mimicry or interacting with peptidyltransferase centers of the ribosome.

  13. Development of reactor design aid tool using virtual reality technology

    Energy Technology Data Exchange (ETDEWEB)

    Mizuguchi, N. [National Institute for Fusion Science, 322-6 Orochi-cho, Toki, Gifu 509-5292 (Japan)]. E-mail: mizu@nifs.ac.jp; Tamura, Y. [National Institute for Fusion Science, 322-6 Orochi-cho, Toki, Gifu 509-5292 (Japan); Imagawa, S. [National Institute for Fusion Science, 322-6 Orochi-cho, Toki, Gifu 509-5292 (Japan); Sagara, A. [National Institute for Fusion Science, 322-6 Orochi-cho, Toki, Gifu 509-5292 (Japan); Hayashi, T. [National Institute for Fusion Science, 322-6 Orochi-cho, Toki, Gifu 509-5292 (Japan)

    2006-11-15

    A new type of aid system for fusion reactor design, to which the virtual reality (VR) visualization and sonification techniques are applied, is developed. This system provides us with an intuitive interaction environment in the VR space between the observer and the designed objects constructed by the conventional 3D computer-aided design (CAD) system. We have applied the design aid tool to the heliotron-type fusion reactor design activity FFHR2m [A. Sagara, S. Imagawa, O. Mitarai, T. Dolan, T. Tanaka, Y. Kubota, et al., Improved structure and long -life blanket concepts for heliotron reactors, Nucl. Fusion 45 (2005) 258-263] on the virtual reality system CompleXcope [Y. Tamura, A. Kageyama, T. Sato, S. Fujiwara, H. Nakamura, Virtual reality system to visualize and auralize numerical imulation data, Comp. Phys. Comm. 142 (2001) 227-230] of the National Institute for Fusion Science, Japan, and have evaluated its performance. The tool includes the functions of transfer of the observer, translation and scaling of the objects, recording of the operations and the check of interference.

  14. Proceedings of the first symposium on utilization of research reactors and JMTR

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-03-01

    The first symposium on utilization of research reactors (JRR-2, JRR-3M, JRR-4) and Japan Materials Testing Reactor (JMTR) in JAERI was held from September 29th to 30th, 1997 at Sannomaru Hotel, Mito. The purpose of this symposium is to announce contribution to progress of scientific technology as well as to promote future utilization of the research reactors and JMTR. During the symposium, 16 reports were presented on nuclear fuel and material, neutron beam experiment, medical irradiation, radioisotope production and neutron activation analysis. The present status of the research reactors and JMTR were also reported. The special lecture titled `JRR-2 and Medical Irradiation` was given by Mr. Nakamura, former editorial writer of Yomiuri. Finally, panel discussion was carried on `The Role of Research Reactors and JMTR in Scientific Technology for the future` actively by the participants and experts in every field of research reactor utilization. 250 people participated in this symposium from universities, national research institutes, private corporations and JAERI. This proceedings briefly summarizes 16 reports, the content of panel discussion and so forth. (J.P.N.)

  15. Study of weed community in the litchi orchard under different pest control models%荔枝园不同害虫治理模式下杂草群落的研究

    Institute of Scientific and Technical Information of China (English)

    柴素芬; 刘桂林; 李雪翠

    2009-01-01

    采用系统调查的方法,对惠州市惠阳永湖百利宏荔枝同不同害虫治理模式下杂荸群落进行研究.结果表明,与自然区相比,对害虫进行化学防治的化防区内杂草群落结构未发生显著变化.化防区杂草有14个科23个种,自然区有14个科22个种,且2个区的多样性指数和均匀度指数基本一致,但其优势种有所不同.化防区的优势种有酢浆草(Oxalis orniculata L.)、芫荽(Coriandrum sativum Linn.)和繁缕(Stellaria monosperma Buch.-Ham.ex D.Don);而自然区的优势种为酢浆草(Oxalis.orniculata L.)、打板归(Polygonum perfoliatum L.)和少花龙葵(Solariumphoteinoearpum Nakamura).

  16. Detectability of bi-gravity with graviton oscillations using gravitational wave observations

    CERN Document Server

    Narikawa, Tatsuya; Tagoshi, Hideyuki; Tanaka, Takahiro; Kanda, Nobuyuki; Nakamura, Takashi

    2014-01-01

    The gravitational waveforms in the ghost-free bi-gravity theory exhibit deviations from those in general relativity. The main difference is caused by graviton oscillations in the bi-gravity theory. We investigate the prospects for the detection of the corrections to gravitational waveforms from coalescing compact binaries due to graviton oscillations and for constraining bi-gravity parameters with the gravitational wave observations. We consider the bi-gravity model discussed by the De Felice-Nakamura-Tanaka subset of the bi-gravity model, and the phenomenological model in which the bi-gravity parameters are treated as independent variables. In both models, the bi-gravity waveform shows strong amplitude modulation, and there can be a characteristic frequency of the largest peak of the amplitude, which depends on the bi-gravity parameters. We show that there is a detectable region of the bi-gravity parameters for the advanced ground-based laser interferometers, such as Advanced LIGO, Advanced Virgo, and KAGRA....

  17. HIGH-EFFICIENCY NITRIDE-BASED SOLID-STATE LIGHTING

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Paul T. Fini; Prof. Shuji Nakamura

    2002-09-01

    In this annual report we summarize the progress obtained in the first year with the support of DoE contract No.DE-FC26-01NT41203, entitled ''High-Efficiency Nitride-Based Solid-State Lighting''. The two teams, from the University of California at Santa Barbara (Principle Investigator: Dr. Shuji Nakamura) and Rensselaer Polytechnic Institute (led by Dr. N. Narendran), are pursuing the goals of this contract from thin film growth, characterization, and packaging standpoints. The UCSB team has made significant progress in the development of GaN vertical cavity surface-emitting lasers (VCSELs) as well as light-emitting diodes (LEDs) with AlGaN active regions emitting in the ultraviolet (UV). The Rensselaer team has developed target specifications for some of the key parameters for the proposed solid-state lighting system, including a luminous flux requirement matrix for various lighting applications, optimal spectral power distributions, and the performance characteristics of currently available commercial LEDs for eventual comparisons to the devices developed in the scope of this project.

  18. HIGH-EFFICIENCY NITRIDE-BASED SOLID-STATE LIGHTING

    Energy Technology Data Exchange (ETDEWEB)

    Dr. Paul T. Fini; Prof. Shuji Nakamura

    2002-04-30

    In this semiannual report we summarize the progress obtained in the first six months with the support of DoE contract No.DE-FC26-01NT41203, entitled ''High-Efficiency Nitride-Based Solid-State Lighting''. The two teams, from the University of California at Santa Barbara (Principle Investigator: Dr. Shuji Nakamura) and Rensselaer Polytechnic Institute (led by Dr. N. Narendran), are pursuing the goals of this contract from thin film growth, characterization, and packaging standpoints. The UCSB team has made significant progress in the development of GaN vertical cavity surface-emitting lasers (VCSELs) as well as light-emitting diodes (LEDs) with AlGaN active regions emitting in the ultraviolet (UV). The Rensselaer team has developed target specifications for some of the key parameters for the proposed solid-state lighting system, including a luminous flux requirement matrix for various lighting applications, optimal spectral power distributions, and the performance characteristics of currently available commercial LEDs for eventual comparisons to the devices developed in the scope of this project.

  19. Simulation of warpage induced by non-isothermal crystallization of co-polypropylene during the SLS process

    Science.gov (United States)

    Amado, Antonio; Schmid, Manfred; Wegener, Konrad

    2015-05-01

    Polymer processing using Additive Manufacturing Technologies (AM) has experienced a remarkable growth during the last years. The application range has been expanding rapidly, particularly driven by the so-called consumer 3D printing sector. However, for applications demanding higher requirements in terms of thermo-mechanical properties and dimensional accuracy the long established AM technologies such as Selective Laser Sintering (SLS) do not depict a comparable development. The higher process complexity hinders the number of materials that can be currently processed and the interactions between the different physics involved have not been fully investigated. In case of thermoplastic materials the crystallization kinetics coupled to the shrinkage strain development strongly influences the stability of the process. Thus, the current investigation presents a transient Finite Element simulation of the warpage effect during the SLS process of a new developed polyolefin (co-polypropylene) coupling the thermal, mechanical and phase change equations that control the process. A thermal characterization of the material was performed by means of DSC, integrating the Nakamura model with the classical Hoffmann-Lauritzen theory. The viscoelastic behavior was measured using a plate-plate rheometer at different degrees of undercooling and a phase change-temperature superposition principle was implemented. Additionally, for validation porpoises the warpage development of the first sintered layers was captured employing an optical device. The simulation results depict a good agreement with experimental measurements of deformation, describing the high sensitivity of the geometrical accuracy of the sintered parts related to the processing conditions.

  20. LUPUS I observations from the 2010 flight of the Balloon-borne large aperture submillimeter telescope for polarimetry

    Energy Technology Data Exchange (ETDEWEB)

    Matthews, Tristan G.; Chapman, Nicholas L.; Novak, Giles [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) and Department of Physics and Astronomy, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (United States); Ade, Peter A. R.; Hargrave, Peter C.; Nutter, David [Cardiff University, School of Physics and Astronomy, Queens Buildings, The Parade, Cardiff, CF24 3AA (United Kingdom); Angilè, Francesco E.; Devlin, Mark J.; Klein, Jeffrey [Department of Physics and Astronomy, University of Pennsylvania, 209 South 33rd Street, Philadelphia, PA 19104 (United States); Benton, Steven J.; Fissel, Laura M.; Gandilo, Natalie N.; Netterfield, Calvin B. [Department of Astronomy and Astrophysics, University of Toronto, 50 St. George Street Toronto, ON M5S 3H4 (Canada); Chapin, Edward L. [XMM SOC, ESAC, Apartado 78, E-28691 Villanueva de la Cañada, Madrid (Spain); Fukui, Yasuo [Department of Physics, Nagoya University, Nagoya 464-8602 (Japan); Gundersen, Joshua O. [Department of Physics, University of Miami, 1320 Campo Sano Drive, Coral Gables, FL 33146 (United States); Korotkov, Andrei L. [Department of Physics, Brown University, 182 Hope Street, Providence, RI 02912 (United States); Moncelsi, Lorenzo; Mroczkowski, Tony K. [California Institute of Technology, 1200 East California Boulevard, Pasadena, CA 91125 (United States); Olmi, Luca [University of Puerto Rico, Rio Piedras Campus, Physics Department, Box 23343, UPR station, San Juan (Puerto Rico); and others

    2014-04-01

    The Balloon-borne Large Aperture Submillimeter Telescope for Polarimetry (BLASTPol) was created by adding polarimetric capability to the BLAST experiment that was flown in 2003, 2005, and 2006. BLASTPol inherited BLAST's 1.8 m primary and its Herschel/SPIRE heritage focal plane that allows simultaneous observation at 250, 350, and 500 μm. We flew BLASTPol in 2010 and again in 2012. Both were long duration Antarctic flights. Here we present polarimetry of the nearby filamentary dark cloud Lupus I obtained during the 2010 flight. Despite limitations imposed by the effects of a damaged optical component, we were able to clearly detect submillimeter polarization on degree scales. We compare the resulting BLASTPol magnetic field map with a similar map made via optical polarimetry. (The optical data were published in 1998 by J. Rizzo and collaborators.) The two maps partially overlap and are reasonably consistent with one another. We compare these magnetic field maps to the orientations of filaments in Lupus I, and we find that the dominant filament in the cloud is approximately perpendicular to the large-scale field, while secondary filaments appear to run parallel to the magnetic fields in their vicinities. This is similar to what is observed in Serpens South via near-IR polarimetry, and consistent with what is seen in MHD simulations by F. Nakamura and Z. Li.

  1. Usefulness of milnacipran in treating phantom limb pain

    Directory of Open Access Journals (Sweden)

    Matsumoto Y

    2012-11-01

    Full Text Available Yasuhide Nagoshi,1 Akira Watanabe,1 Saiko Inoue,1 Tomoki Kuroda,2 Mitsuo Nakamura,3 Yoshitake Matsumoto,4 Kenji Fukui31Department of Psychiatry (Psychosomatic Medicine, Kyoto First Red Cross Hospital, Kyoto, Japan; 2Gojouyama Hospital, Nara, Japan; 3Department of Psychiatry, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 4Matsumoto Clinic, Kyoto, JapanBackground: Amputation of an extremity often results in the sensation of a “phantom limb” where the patient feels that the limb that has been amputated is still present. This is frequently accompanied by “phantom limb pain”. We report here the use of milnacipran, a serotonin and norepinephrine reuptake inhibitor, to treat phantom limb pain after amputation of injured or diseased limbs in three patients.Methods and results: The severity of phantom pain before and during treatment was quantified using a visual analog scale. In one case, phantom limb pain responded partially to treatment with high doses of paroxetine, and then replacement with milnacipran further improved the pain relief and long-term full pain relief was achieved. In the two other cases, milnacipran was used as first-line treatment and phantom limb pain responded rapidly.Conclusion: These results suggest that milnacipran administration may be useful in phantom limb pain, possibly as a first-line treatment.Keywords: milnacipran, paroxetine, phantom limb pain, selective serotonin reuptake inhibitor (SSRI, serotonin and norepinephrine reuptake inhibitor (SNRI

  2. Masked translation priming asymmetry in Chinese-English bilinguals: making sense of the Sense Model.

    Science.gov (United States)

    Xia, Violet; Andrews, Sally

    2015-01-01

    Masked translation priming asymmetry is the robust finding that priming from a bilingual's first language (L1) to their second language (L2) is stronger than priming from L2 to L1. This asymmetry has been claimed to be task dependent. The Sense Model proposed by Finkbeiner, Forster, Nicol, and Nakamura (2004) claims that the asymmetry is reduced in semantic categorization relative to lexical decision due to a category filtering mechanism that limits the features considered in categorization decisions to dominant, category-relevant features. This paper reports two pairs of semantic categorization and lexical decision tasks designed to test the Sense Model's predictions. The experiments replicated the finding of Finkbeiner et al. that L2-L1 priming is somewhat stronger in semantic categorization than lexical decision, selectively for exemplars of the category. However, the direct comparison of L2-L1 and L1-L2 translation priming across tasks failed to confirm the Sense Model's central prediction that translation priming asymmetry is significantly reduced in semantic categorization. The data therefore fail to support the category filtering account of translation priming asymmetry. Rather, they suggest that pre-activation of conceptual features of the target category provides feedback to lexical forms that compensates for the weak connections between the lexical and conceptual representations of L2 words.

  3. Kölliker-Fuse GABAergic and glutamatergic neurons project to distinct targets.

    Science.gov (United States)

    Geerling, Joel C; Yokota, Shigefumi; Rukhadze, Irma; Roe, Dan; Chamberlin, Nancy L

    2017-06-01

    The Kölliker-Fuse nucleus (KF) is known primarily for its respiratory function as the "pneumotaxic center" or "pontine respiratory group." Considered part of the parabrachial (PB) complex, KF contains glutamatergic neurons that project to respiratory-related targets in the medulla and spinal cord (Yokota, Oka, Tsumori, Nakamura, & Yasui, 2007). Here we describe an unexpected population of neurons in the caudal KF and adjacent lateral crescent subnucleus (PBlc), which are γ-aminobutyric acid (GABA)ergic and have an entirely different pattern of projections than glutamatergic KF neurons. First, immunofluorescence, in situ hybridization, and Cre-reporter labeling revealed that many of these GABAergic neurons express FoxP2 in both rats and mice. Next, using Cre-dependent axonal tracing in Vgat-IRES-Cre and Vglut2-IRES-Cre mice, we identified different projection patterns from GABAergic and glutamatergic neurons in this region. GABAergic neurons in KF and PBlc project heavily and almost exclusively to trigeminal sensory nuclei, with minimal projections to cardiorespiratory nuclei in the brainstem, and none to the spinal cord. In contrast, glutamatergic KF neurons project heavily to the autonomic, respiratory, and motor regions of the medulla and spinal cord previously identified as efferent targets mediating KF cardiorespiratory effects. These findings identify a novel, GABAergic subpopulation of KF/PB neurons with a distinct efferent projection pattern targeting the brainstem trigeminal sensory system. Rather than regulating breathing, we propose that these neurons influence vibrissal sensorimotor function. © 2017 Wiley Periodicals, Inc.

  4. LLE Review Quarterly Report July-September 2000

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-12-01

    This volume of the LLE Review, covering July-September 2000, begins with an article by T. R. Boehly, V. N. Goncharov, O. Gotchev, J. P. Knauer, D. D. Meyerhofer, D. Oron, S. P. Regan, Y. Srebro, W. Seka, D. Shvarts, S. Skupsky, and V.A. Smalyuk, who describe measurements of the effect of beam smoothing and pulse shape on imprinting. (Imprinting is defined as the imposition of pressure perturbations on the target by spatial variations in the laser intensity.) A principal result is the observation of reduced levels of imprint with the higher beam smoothing afforded by 1-THz smoothing by spectral dispersion (SSD). Additional highlights of research presented in this issue are: (1) P. W. McKenty, V. N. Goncharov, R. P. J. Town, S. Skupsky, R. Betti, and R. L. McCrory describe calculations of directly driven ignition capsule performance on the National Ignition Facility (NIF). The authors detail how the various contributors to implosion disruption (laser imprint, power imbalance, and target roughness) affect target performance and final gain. The conclusions are obtained by examining the simulated target evolution with the two-dimensional hydrodynamics computer code ORCHID. (2) D. D. Meyerhofer, J. A. Delettrez, R. Epstein, V. Yu. Glebov, V. N. Goncharov, R. L. Keck, R. L. McCrory, P. W. McKenty, F. J. Marshall, P. B. Radha, S. P. Regan, S. Roberts, W. Seka, S. Skupsky, V. A. Smalyuk, C. Sorce, C. Stoeckl, J. M. Soures, R. P. J. Town, B. Yaakobi, J. D. Zuegel, J. Frenje, C. K. L1,R. D. Petrasso, F. Seguin, K. Fletcher, S. Padalino, C. Freeman, N. Izumi, R. Lerche, T. W. Phillips, and T. C. Sangster describe the results of a series of direct-drive implosions of gas-fusion-fuel-filled plastic shells performed on the OMEGA laser system. The experiments include those performed with 1-THZ SSD and high-quality power balance. (3) V. Yu. Glebov, D. D. Meyerhofer, C. Stoeckl, and J. D. Zuegel describe the technique of measuring secondary neutron yield (DT neutron yield from D

  5. Polypharmacy and adverse drug reactions in Japanese elderly taking antihypertensives: a retrospective database study

    Directory of Open Access Journals (Sweden)

    Sato I

    2013-06-01

    Full Text Available Izumi Sato,1 Manabu Akazawa21Department of Epidemiology and Statistics, Graduate School of Medicine, The University of Tokyo Tokyo, Japan; 2Department of Public Health and Epidemiology, Meiji Pharmaceutical University, Tokyo, JapanBackground: The concomitant use of multiple medications by elderly patients with hypertension is a relatively common and growing phenomenon in Japan. This has been attributed to several factors, including treatment guidelines recommending prescription of multiple medications and a continuing increase in the elderly population with multiple comorbidities.Objective: This study was aimed at investigating the association between polypharmacy, defined as the concomitant use of five or more medications, and risk of adverse drug reaction (ADR in elderly Japanese hypertensive patients to examine the hypothesis that risk of ADR increases with the administration of an increasing number of co-medications.Methods: Using a retrospective cohort design, the data regarding all hypertensive patients aged 65 years or older were extracted from the Risk/Benefit Assessment of Drugs – Analysis and Response Council antihypertensive medication database. The data were reviewed for classification of patients into one of three groups according to drug use at the initiation of therapy – a monotherapy group composed of patients who had taken the investigated drug only, a co-medication group composed of patients who had taken the investigated drug and a maximum of three other medications, and a polypharmacy group composed of patients who had taken the investigated drug and four or more other medications – and determination of the number of ADR events experienced. Estimated rate ratios (RRs and 95% confidence intervals (CIs were calculated using a Poisson regression model adjusted for drug category and patient age and sex. Various sensitivity analyses were performed to confirm the robustness of the study findings.Results: Of 61,661 elderly

  6. iPS-Cinderella Story in Cell Biology

    Directory of Open Access Journals (Sweden)

    Editorial

    2010-01-01

    pluripotency and thus paving the way for use of iPS in humansIn this issue of JSRM we have Dr.Yukio Nakamura writing about Disease specific iPS cells which could serve as tools for understanding the underlying mechanisms of diseases which are less understood so far or which could be used as study models for drug discovery for disease therapy. Adding another positive futuristic step to this is the paper by Kataoka et al., who have shown that the iPS cells could be grown in a three dimensional scaffold in which their earlier studies have shown feasibility of a 200 time passaging of mouse foteal epithelial stem cells and neural stem cells. The strengths of Nakamura et al and that of Kataoka et al combined virtually, we see a much brighter picture for the iPS cells which might be in future much cleaner, be grown in an undifferentiated manner and be stored for long; then instead of cord blood storage all I dream is whenever a child is born we may simply custom make iPS for that child and cryopreserve it; May the dreams come true!Dr. Sheikh Riazuddin’s article about lin-c-kit+ BM-derived stem cells repair Infarcted Heart and Dr.Pravin Potdar’s article about Mesenchymal Stem Cells from adipose tissue give some basic understandings of the possible clinical translations. Happy reading!

  7. Investigations on alluvial deposits through borehole stratigraphy, radiocarbon dating and passive seismic technique (Carnic Alps, NE Italy)

    Science.gov (United States)

    Viero, Alessia; Marchi, Lorenzo; Cavalli, Marco; Crema, Stefano; Fontana, Alessandro; Mozzi, Paolo; Venturini, Corrado

    2016-04-01

    their extent and the maximum depths. Two passive seismic campaigns were carried out near the borehole site and along the But valley at different elevations. The aim was to investigate the depth of the buried bedrock and therefore to indirectly characterize the thickness of alluvial deposits. We calibrated the fundamental frequency of each site by constraining average shear velocity of the alluvial sediments close to the borehole site with known stratigraphy. Eight HVSR (Horizontal to Vertical Spectral Ratio, Nakamura, 1989) were carried out, and thus a first sketch of the buried valley floor along a longitudinal profile of about 5 km was depicted. The values of the derived bedrock depth allow to quantify the differences in thickness between the alluvial deposits and the Moscardo Torrent fan deposits. This information helps to address the contribution of the debris-flow processes in damming the upper But River during the last five centuries. The results confirm the role of debris-flow deposits from the Moscardo Torrent in shaping the morphology of the valley floor of But River and show suitability of an integrated approach, encompassing log stratigraphy, geophysical surveys and analysis of historical documents, for gaining insights on the evolution of alpine valleys. Reference Nakamura, Y., 1989. A method for dynamic characteristic estimation of subsurface using microtremor on the ground surface. Quarterly Report of Railway Technical Research Institute, 30(1): 25-33.

  8. JENIS, UKURAN DAN DAERAH PENANGKAPAN HIU THRESHER (FAMILI ALOPIIDAE YANG TERTANGKAP RAWAI TUNA DI SAMUDERA HINDIA

    Directory of Open Access Journals (Sweden)

    Agustinus Anung Widodo

    2016-03-01

    Full Text Available Sebagai anggota Indian Ocean Tuna Commision (IOTC Indonesia wajib mengadopsi isi Resolusi IOTC 10/12 yang mengatur pengelolaan sumberdaya ikan hiu thresher (famili Alopiidae. Secara spesifik Indonesia belum melaksanakan pengelolaan sumberdaya hiu thresher karena spesies tersebut belum mendapatkan perhatian serius. Tulisan ini bermaksud menyampaikan hasil penelitian tentang ikan hiu thresher (Famili Alopiidae yang tertangkap rawai tuna di Samudera Hindia berbasis di Cilacap. Data diperoleh dari kegiatan pengambilan contoh di pelabuhan tahun 2010, kegiatan observasi di atas kapal rawai tuna bulan Januari 2010 dan laporan statistik PPS Cilacap tahun 2006-2010. Hasil kajian menunjukkan bahwa: (a di perairan Indonesia ada dua spesies dari tiga spesies hiu thresher yang ada di dunia, yaitu hiu monyet atau pelagic thresher (Alopias pelagicus Nakamura 1935 dan hiu paitan atau bigeye thresher (A. superciliosus Lowe 1840. Satu spesies lainnya yang belum pernah ditemukan adalah thinfin thresher (A.vulpinus Bonnaterre1788.  Dilihat dari teknologi rawai tuna yang digunakan, daerah sebaran hiu thresher sama dengan tuna di Samudera Hindia, sehingga sulit untuk menghindari tidak tertangkapnya hiu thresher oleh rawai tuna. Jumlah dari jenis hiu monyet yang tertangkap rawai tuna di Samudera Hindia berkisar 0,1-0,6 % dan hiu paitan berkisar 0,1-1,3 % dari total tangkapan. Ukuran hiu thresher yang tertangkap rawai tuna umumnya ikan yang telah dewasa (berkisar 54-74% dan diduga telah mengalami pemijahan. Hampir semua bagian hiu thresher dimanfaatkan sebagai bahan pangan dan farmasi. Selain dipasarkan di dalam negeri, ikan hiu thresher juga diekspor terutama siripnya ke manca negara dan terbanyak ke China.   As a member of IOTC, Indonesia is obliged to implement all IOTC’s resolutions including resolution 10/12 on the conservation of thresher sharks (Family Alopiidae caught in association with fisheries in the IOTC area of competence. Indonsia has not

  9. Relationship between sleep duration and clustering of metabolic syndrome diagnostic components

    Directory of Open Access Journals (Sweden)

    Katano S

    2011-04-01

    Full Text Available Sayuri Katano1, Yasuyuki Nakamura1,2, Aki Nakamura1, Yoshitaka Murakami3, Taichiro Tanaka4, Toru Takebayashi5, Akira Okayama6, Katsuyuki Miura2, Tomonori Okamura7, Hirotsugu Ueshima2, for HIPOP-OHP Research Group1Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan; 2Department of Health Science, Shiga University of Medical Science, Otsu, Japan; 3Department of Medical Statistics, Shiga University of Medical Science, Otsu, Japan; 4Department of Health Sciences, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo, Japan; 5Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan; 6The First Institute of Health Service, Japan Anti-Tuberculosis Association, Tokyo, Japan; 7Department of Preventive Cardiology, National Cardiovascular Center, Suita, JapanObjective: To examine the relation between sleep duration and metabolic syndrome (MetS.Methods: We examined the baseline data from 4356 healthy workers (3556 men and 800 women aged 19–69 years. The physical activity of each participant was classified according to the International Physical Activity Questionnaire (IPAQ. We defined four components of MetS diagnostic components in this study as follows: 1 high blood pressure (BP systolic BP [SBP] ≥ 130 mmHg, or diastolic BP [DBP] ≥ 85 mmHg, or on medication; 2 dyslipidemia (high-density lipoprotein-cholesterol concentration ,40 mg/dL, or triglycerides concentration ≥150 mg/dL, or on medication; 3 impaired glucose tolerance (fasting blood sugar concentration ≥ 110 mg/dL, or if less than 8 hours after meals ≥ 140 mg/dL, or on medication; and 4 overweight (body mass index [BMI] ≥ 25 kg/m2, or obesity (BMI ≥ 30 kg/m2. There were 680 participants in the group, with sleep duration <6 hours (15.6%.Results: Those who had 0–4 MetS diagnostic components, including overweight, accounted for 2159, 1222, 674, 255, and 46 participants, respectively, in

  10. Book Reviews

    Directory of Open Access Journals (Sweden)

    V. M. Clara van Groenendael

    1986-10-01

    Full Text Available - Dennis Tedlock, Dennis Tedlock, The Spoken Word - Reaction to R. de Ridder’s review of The Spoken Word and Popul Vuh (BKI 142-I, 1986, pp. 179-182. - J.G. de Casparis, Kenneth R. Hall, Maritime trade and state development in early Southeast Asia, Honolulu: University of Hawaii Press, 1985, 368 pp. - M. Hekker, J.E. Ellemers, Indische Nederlanders en gerepatrieerden, Muiderberg: Coutinho, 1985. 159 pp., foto’s., R.E.F. Vaillant (eds. - Tineke Hellwig, Els Postel-Coster, Het omheinde kweekbed; Machtsverhoudingen in de Minangkabause familieroman, Delft: Eburon, 233 pp., 1985. - H.A.J. Klooster, Sartono Kartodirdjo, Modern Indonesia, tradition and transformation. A socio-historical perspective, Yogyakarta: Gadjah Mada University Press, 1984, xii + 299 pp. - Gert J. Oostindie, W.S.M. Hoogbergen, De Boni-oorlogen 1757-1860. Marronage en guerilla [sic] in Oost-Suriname. Utrecht: Rijksuniversiteit 1985. [Bronnen voor de studie van Afro-amerikaanse samenlevingen in de Guyana’s, 528 pp. - P. Pink, V. M. Clara van Groenendael, The Dalang behind the Wayang. The role of the Surakarta and the Yogyakarta dalang in Indonesian-Javanese society, Verhandelingen van het Koninklijk Instituut voor Taal-, Land- en Volkenkunde 114, Dordrecht-Holland/Cinnaminson-U.S.A.: Foris publications, 1985, VIII + 242 pp., 3 maps. - P. Pink, J. Kats, De Wajang Poerwa, een vorm van Javaans Toneel, ingeleid door J.J. Ras en H.A. Poeze, Koninklijk Instituut voor Taal-, Land- en Volkenkunde, Indonesische Herdrukken, Dordrecht-Holland/Cinnaminson-U.S.A.: Foris publications, 1984, XL VIII + VIII + 446 pp. - S. Pompe, Hisako Nakamura, Divorce in Java, Gadjah Mada University Press, Yogyakarta 1983, xxiii + 145 pp. - J.M.C. Pragt, Wim Bakker, Bali verbeeld, Volkenkundig Museum Nusantara, Delft, 1985, 96 p., 120 afb.

  11. False-negative rate, limit of detection and recovery efficiency performance of a validated macrofoam-swab sampling method for low surface concentrations of Bacillus anthracis Sterne and Bacillus atrophaeus spores

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, G. F. [Applied Statistics and Computational Sciences, Pacific Northwest National Laboratory, Richland WA USA; Deatherage Kaiser, B. L. [Chemical and Biological Signature Science Group, Pacific Northwest National Laboratory, Richland WA USA; Amidan, B. G. [Applied Statistics and Computational Sciences, Pacific Northwest National Laboratory, Richland WA USA; Sydor, M. A. [Chemical and Biological Signature Science Group, Pacific Northwest National Laboratory, Richland WA USA; Barrett, C. A. [Analytical Chemistry of Nuclear Materials, Pacific Northwest National Laboratory, Richland WA USA; Hutchison, J. R. [Chemical and Biological Signature Science Group, Pacific Northwest National Laboratory, Richland WA USA

    2016-05-06

    The performance of a macrofoam-swab sampling method was evaluated using Bacillus anthracis Sterne (BAS) and Bacillus atrophaeus Nakamura (BG) spores applied at nine low target amounts (2-500 spores) to positive-control plates and test coupons (2 in × 2 in) of four surface materials (glass, stainless steel, vinyl tile, and plastic). Test results from cultured samples were used to evaluate the effects of surrogate, surface concentration, and surface material on recovery efficiency (RE), false negative rate (FNR), and limit of detection. For RE, surrogate and surface material had statistically significant effects, but concentration did not. Mean REs were the lowest for vinyl tile (50.8% with BAS and 40.2% with BG) and the highest for glass (92.8% with BAS and 71.4% with BG). FNR values ranged from 0 to 0.833 for BAS and 0 to 0.806 for BG; values increased as concentration decreased in the range tested (0.078 to 19.375 CFU/cm2). Surface material also had a statistically significant effect. A FNR-concentration curve was fit for each combination of surrogate and surface material. For both surrogates, the FNR curves tended to be the lowest for glass and highest for vinyl title. The FNR curves for BG tended to be higher than for BAS at lower concentrations, especially for glass. Results using a modified Rapid Viability-Polymerase Chain Reaction (mRV-PCR) analysis method were also obtained. The mRV-PCR results and comparisons to the culture results will be discussed in a subsequent article.

  12. Evaluating Composite Sampling Methods of Bacillus spores at Low Concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Hess, Becky M.; Amidan, Brett G.; Anderson, Kevin K.; Hutchison, Janine R.

    2016-10-13

    Restoring facility operations after the 2001 Amerithrax attacks took over three months to complete, highlighting the need to reduce remediation time. The most time intensive tasks were environmental sampling and sample analyses. Composite sampling allows disparate samples to be combined, with only a single analysis needed, making it a promising method to reduce response times. We developed a statistical experimental design to test three different composite sampling methods: 1) single medium single pass composite: a single cellulose sponge samples multiple coupons; 2) single medium multi-pass composite: a single cellulose sponge is used to sample multiple coupons; and 3) multi-medium post-sample composite: a single cellulose sponge samples a single surface, and then multiple sponges are combined during sample extraction. Five spore concentrations of Bacillus atrophaeus Nakamura spores were tested; concentrations ranged from 5 to 100 CFU/coupon (0.00775 to 0.155CFU/cm2, respectively). Study variables included four clean surface materials (stainless steel, vinyl tile, ceramic tile, and painted wallboard) and three grime coated/dirty materials (stainless steel, vinyl tile, and ceramic tile). Analysis of variance for the clean study showed two significant factors: composite method (p-value < 0.0001) and coupon material (p-value = 0.0008). Recovery efficiency (RE) was higher overall using the post-sample composite (PSC) method compared to single medium composite from both clean and grime coated materials. RE with the PSC method for concentrations tested (10 to 100 CFU/coupon) was similar for ceramic tile, painted wall board, and stainless steel for clean materials. RE was lowest for vinyl tile with both composite methods. Statistical tests for the dirty study showed RE was significantly higher for vinyl and stainless steel materials, but significantly lower for ceramic tile. These results suggest post-sample compositing can be used to reduce sample analysis time when

  13. A Dynamical Origin Of The Leading/trailing Asymmetry In Jupiter's Trojan Swarms?

    Science.gov (United States)

    O'Brien, David P.

    2012-10-01

    The cataloged population of Jupiter Trojans has long shown a puzzling asymmetry between the leading (L4) and trailing (L5) swarms down to the smallest observable sizes. Estimates from the Sloan Digital Sky Survey (SDSS) place the leading/trailing ratio at 1.6 ± 0.1 [1], survey observations with the Subaru telescope give a leading/trailing ratio of around 1.8 [2], and most recently, estimates from the WISE mission give a leading/trailing ratio of 1.4 ± 0.2 [3]. Current models for Trojan capture [eg. 4] predict that the two swarms should begin with roughly equal numbers of bodies, and there is no inherent difference in stability between the leading and trailing swarms in the three-body problem. However, several researchers have proposed that when Saturn is included in the dynamics, the trailing swarm might be less stable than the leading swarm [5-8], and this difference may be able to explain the asymmetry. Here we test that hypothesis with long-term orbital integrations using a wider range of initial conditions than explored by those authors. References: [1] Szabo, G. M. et al., MNRAS 377, 1393-1406 (2007). [2] Nakamura, T. and Yoshida, F., PASJ 60, 293-296 (2008). [3] Grav, T. et al., ApJ 742, 40-49 (2011). [4] Morbidelli, A. et al., Nature 435, 462-465 (2005). [5] Pal, A. and Suli, A., Publications of the Astronomy Department of the Eotvos University (PADEU) 14, 285-292 (2004). [6] Schwarz, R. et al., CMDA 90, 139-148 (2004). [7] Dvorak, R. and Schwarz, R., CMDA 92, 19-28 (2005). [8] Freistetter, F., A&A 453, 353-361 (2006).

  14. Plasmid dependence of Pseudomonas sp. strain NK87 enzymes that degrade 6-aminohexanoate-cyclic dimer.

    Science.gov (United States)

    Kanagawa, K; Negoro, S; Takada, N; Okada, H

    1989-06-01

    A bacterial strain, Pseudomonas sp. strain NK87, that can use 6-aminohexanoate-cyclic dimer as the sole source of carbon and nitrogen was newly isolated from wastewater of a factory which produces nylon-6. Two responsible enzymes, 6-aminohexanoate-cyclic-dimer hydrolase (P-EI) and 6-aminohexanoate-dimer hydrolase (P-EII), were found in the NK87 strain, as is the case with Flavobacterium sp. strain KI72, another 6-aminohexanoate-cyclic-dimer-metabolizing bacterium (H. Okada, S. Negoro, H. Kimura, and S. Nakamura, Nature [London] 306:203-206, 1983). The P-EI enzyme is immunologically identical to the 6-aminohexanoate-cyclic-dimer hydrolase of KI72 (F-EI). However, antiserum against the 6-aminohexanoate-dimer hydrolase purified from KI72 (F-EII) did not react with cell extracts of NK87, indicating that the F-EII and P-EII enzymes are immunologically different. Restriction endonuclease analyses show that the NK87 strain harbors at least six plasmids ranging in size from 20 to 80 kilobase pairs (kbp). The P-EI and P-EII genes were cloned in Escherichia coli. Both the P-EI and F-EI probes strongly hybridized with a 23-kbp plasmid in Southern hybridization analyses. The P-EII probe hybridized specifically with an 80-kbp plasmid, but the F-EII probe hybridized with none of the plasmids harbored in NK87. These results indicate that the P-EI gene and P-EII gene are encoded on the 23-kbp and 80-kbp plasmids, respectively.

  15. Parental bonding and attitudes toward suicide among medical college students in Japan

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    Hashimoto K

    2014-10-01

    Full Text Available Kojiro Hashimoto,1 Norio Sugawara,2 Osamu Tanaka,2 Kazuhiko Nakamura,1 Norio Yasui-Furukori1 1Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, Aomori, Japan; 2Aomori Prefectural Center for Mental Health and Welfare, Aomori, Japan Background: Suicide is a grave public health issue that is responsible for a high mortality rate among individuals aged 15–44 years. Attitudes toward suicide among medical staff members have been associated with appropriate therapeutic responses to suicidal individuals. The aim of this study was to examine the effects of parental rearing on attitudes toward suicide among Japanese medical college students. Methods: We examined the association between parental bonding and attitudes toward suicide in 160 medical college students in Japan. The Parental Bonding Instrument was used to assess the attitudes and behaviors of parents. The attitudes toward suicide were evaluated using the Japanese version of the Attitudes Toward Suicide questionnaire. Results: The mean age of the subjects was 25.2±4.0 years old. The majority of the participants in our study agreed that anyone could commit suicide (88.8% and that suicide is preventable (86.3%. After adjusting for age and sex, multivariate regression analysis revealed that maternal care approached a statistically significant association with the “right to suicide” attitude. Under the same conditions, maternal care was shown to be significantly associated with the “common occurrence” attitude. No other significant relationships were observed between parental bonding and attitudes toward suicide.Conclusion: This study suggests that a higher level of maternal care ensures that children think that suicide occurs less commonly. The promotion of best practices for suicide prevention among medical students is needed. Child rearing support might be associated with suicide prevention.Keywords: attitudes toward suicide, Japanese, medical college

  16. Evaluation of factors influencing stable microbubble test results in preterm neonates at 30–33 gestational weeks

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    Teslova OA

    2012-02-01

    Full Text Available Oxana A Teslova1,2, Takehiko Hiroma1, Elena I Baranovskaya2, Tomohiko Nakamura11Division of Neonatology, Nagano Children's Hospital, Azumino City, Nagano, Japan; 2Department of Obstetrics and Gynecology, Gomel State Medical University, BelarusBackground: The stable microbubble test (SMT is a sensitive and specific means of predicting respiratory distress syndrome in newborns, using quantitative correlations with concentrations of the protein and lipid components of surfactant. We hypothesized that fetal nutrition would affect the synthesis of surfactant components. The objectives of this study were to evaluate aspects of fetal and maternal nutrition influencing SMT results and related to development of respiratory distress syndrome in preterm neonates.Methods: Data from 194 preterm neonates of gestational age 23–36 weeks were analyzed using multivariate regression modeling to identify factors influencing SMT results. After adjusting for gestational age, we compared obstetric, maternal, neonatal, and placental data using analysis of variance in 99 neonates at 30–33 weeks of gestation based on results of the SMT. Receiver-operating-characteristic analysis was performed to characterize factors predictive of respiratory distress syndrome.Results: SMT results were most strongly associated with the concentration of protein in neonatal blood (P < 0.05 and maternal weight gain during pregnancy (P < 0.05. Cutoff values for predicting respiratory distress syndrome were serum protein <4.7 g/L and maternal weight gain <200 g/week.Conclusion: Inadequate maternal weight gain during pregnancy may play a significant role in immaturity of the surfactant system in the lungs and may be a predictor of respiratory distress syndrome in premature babies.Keywords: stable microbubble test, respiratory distress syndrome, protein concentration, gestational weight gain

  17. Inter-sport variability of muscle volume distribution identified by segmental bioelectrical impedance analysis in four ball sports

    Directory of Open Access Journals (Sweden)

    Yamada Y

    2013-04-01

    Full Text Available Yosuke Yamada,1,2 Yoshihisa Masuo,3 Eitaro Nakamura,4 Shingo Oda5 1Laboratory of Sports and Health Science, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Japan Society for the Promotion of Science, Tokyo, Japan; 3Waseda University Research Institute for Elderly Health, Saitama, Japan; 4Department of Sport Science, Kyoto Iken College of Medicine and Health, Kyoto, Japan; 5Faculty of Health and Well-being, Kansai University, Osaka, Japan Abstract: The aim of this study was to evaluate and quantify differences in muscle distribution in athletes of various ball sports using segmental bioelectrical impedance analysis (SBIA. Participants were 115 male collegiate athletes from four ball sports (baseball, soccer, tennis, and lacrosse. Percent body fat (%BF and lean body mass were measured, and SBIA was used to measure segmental muscle volume (MV in bilateral upper arms, forearms, thighs, and lower legs. We calculated the MV ratios of dominant to nondominant, proximal to distal, and upper to lower limbs. The measurements consisted of a total of 31 variables. Cluster and factor analyses were applied to identify redundant variables. The muscle distribution was significantly different among groups, but the %BF was not. The classification procedures of the discriminant analysis could correctly distinguish 84.3% of the athletes. These results suggest that collegiate ball game athletes have adapted their physique to their sport movements very well, and the SBIA, which is an affordable, noninvasive, easy-to-operate, and fast alternative method in the field, can distinguish ball game athletes according to their specific muscle distribution within a 5-minute measurement. The SBIA could be a useful, affordable, and fast tool for identifying talents for specific sports. Keywords: discriminant analysis, cluster and factor analysis, segmental bioelectrical impedance analysis, baseball, lacrosse

  18. The effects of kinematically aligned total knee arthroplasty on stress at the medial tibia

    Science.gov (United States)

    Tian, Y.; Tanaka, Y.; Kuriyama, S.; Ito, H.; Furu, M.; Matsuda, S.

    2017-01-01

    Objectives Little biomechanical information is available about kinematically aligned (KA) total knee arthroplasty (TKA). The purpose of this study was to simulate the kinematics and kinetics after KA TKA and mechanically aligned (MA) TKA with four different limb alignments. Materials and Methods Bone models were constructed from one volunteer (normal) and three patients with three different knee deformities (slight, moderate and severe varus). A dynamic musculoskeletal modelling system was used to analyse the kinematics and the tibiofemoral contact force. The contact stress on the tibial insert, and the stress to the resection surface and medial tibial cortex were examined by using finite element analysis. Results In all bone models, posterior translation on the lateral side and external rotation in the KA TKA models were greater than in the MA TKA models. The tibiofemoral force at the medial side was increased in the moderate and severe varus models with KA TKA. In the severe varus model with KA TKA, the contact stress on the tibial insert and the stress to the resection surface and to the medial tibial cortex were increased by 41.5%, 32.2% and 53.7%, respectively, compared with MA TKA, and the bone strain at the medial side was highest among all models. Conclusion Near normal kinematics was observed in KA TKA. However, KA TKA increased the contact force, stress and bone strain at the medial side for moderate and severe varus knee models. The application of KA TKA for severe varus knees may be inadequate. Cite this article: S. Nakamura, Y. Tian, Y. Tanaka, S. Kuriyama, H. Ito, M. Furu, S. Matsuda. The effects of kinematically aligned total knee arthroplasty on stress at the medial tibia: A case study for varus knee. Bone Joint Res 2017;6:43–51. DOI: 10.1302/2046-3758.61.BJR-2016-0090.R1. PMID:28077396

  19. MHD free convection flow of Eyring–Powell fluid from vertical surface in porous media with Hall/ionslip currents and ohmic dissipation

    Directory of Open Access Journals (Sweden)

    S. Abdul Gaffar

    2016-06-01

    Full Text Available A mathematical study is presented to analyze the nonlinear, non-isothermal, magnetohydrodynamic (MHD free convection boundary layer flow, heat and mass transfer of non-Newtonian Eyring–Powell fluid from a vertical surface in a non-Darcy, isotropic, homogenous porous medium, in the presence of Hall currents and ionslip currents. The governing nonlinear coupled partial differential equations for momentum conservation in the x, and z directions, heat and mass conservation, in the flow regime are transformed from an (x, y, z coordinate system to a (ξ, η coordinate system in terms of dimensionless x-direction velocity (f′ and z-direction velocity (G, dimensionless temperature and concentration functions (θ and ϕ under appropriate boundary conditions. Both Darcian and Forchheimer porous impedances are incorporated in both momentum equations. Computations are also provided for the variation of the x and z direction shear stress components and also heat and mass transfer rates. It is observed that with increasing ɛ, primary velocity, secondary velocity, heat and mass transfer rates are decreased whereas, the temperature, concentration and skin friction are increased. An increasing δ is found to increase primary and secondary velocities, skin friction, heat and mass transfer rates. But the temperature and concentration decrease. Increasing βe and βi are seen to increase primary velocity, skin friction, heat and mass transfer rates whereas secondary velocity, temperature and concentration are decreased. Excellent correlation is achieved with a Nakamura tridiagonal finite difference scheme (NTM. The model finds applications in magnetic materials processing, MHD power generators and purification of crude oils.

  20. Site response assessment at the city of Alkhobar, Eastern Saudi Arabia from microtremor and boring data

    Science.gov (United States)

    Fnais, M. S.

    2014-12-01

    The AlKhobar City affected by distant earthquakes from Zagros fold-fault belt of subduction zone. These earthquakes produced great site effects on the sedimentary layers that in turn significantly influenced earthquake ground motions in the area. Mapping of site response using microtremor measurements compared with geological and borehole data of Alkhobar city is the main target of this work. The resonance frequency and their H/V values have been calculated using Nakamura technique through deployed of seismograph instruments at 113 sites in AlKhobar city for different time periods. The recording length was about one hour with sampling frequency of 100 Hz. Most of the measured sites present three peaks for the resonance frequency; the first peak ranges from 0.33 to 1.03 Hz, the second peak ranges from 1.03 to 1.23 Hz, while the third peak ranges from 1.23-1.73. Tests have been conducted to ensure that these peaks are natural in origin. The northern zones of AlKhobar City have lower values of resonance frequency indicating great thickness of sediments. In contrast, the southern parts of the city have higher values of resonance frequency illustrating shallow depths of the bedrock. Furthermore, twenty of boreholes have been conducted through AlKhobar City to different depth. Standard penetration test (SPT) data has been corrected and used to calculate the resonance frequency at their locations. Borehole results clarified that the resonance frequency values range from 0.27 to 1.95 Hz. These results are correlated well with that of the microtremor measurements. Accordingly, the first peak have been interpreted due to the impedance contrast between the limestone and the overlying sediments, while the third peak is originated from a boundary between the upper most surface layer and the underlying sediments. These results must be applied for earthquake risk mitigation in AlKhobar City.

  1. Rupture Process of the 2003 Bam, Iran, Earthquake: Did Shallow Asperities on a Fresh Fault Cause Extreme Ground Motions?

    Science.gov (United States)

    Miyake, H.; Koketsu, K.; Mostafaei, H.

    2004-12-01

    The Bam, Iran, earthquake on December 26, 2003 caused heavy damage to the city of Bam including the historic heritage of Arg-e-Bam. This Mw6.5 earthquake rupture created fresh faults 5 km westward away from the Bam fault. The Bam strong-motion station recorded 992 gal in the UD component and two directivity pulses in the horizontal components with a dominant frequency of 1 Hz. We inferred the rupture process of the 2003 Bam earthquake from strong motion data observed by BHRC, together with teleseismic data to constrain global features of the source. Waveform inversions using teleseismic data (e.g. Yamanaka, 2003; Yagi, 2003) have suggested the existence of a shallow asperity. Nakamura et al. (2004) estimated aftershock distribution with vertical dipping that superimposed the fresh faults, not the Bam fault. They proposed fault planes consisting N-S alignment with northward branches beneath the city of Bam. Our preliminary analyses show that two directivity pulses are created by northward rupture near the hypocenter and north-eastward rupture beneath the city. Recent earthquakes occurred on immature faults with shallow asperities have also generated localized extreme-strong motions (e.g., 2003 Miyagi-ken Hokubu, Japan, with Mw6.1; 2000 Tottori, Japan, with Mw6.6). Larger fracture energy is expected for shallow asperities on immature faults than those on mature faults. For example, the 2000 Tottori earthquake has several times larger fracture energy than expected by the scaling between seismic moment and fracture energy. When considering the energy budget, are radiated energy from the immature faults enough to generate the extreme ground motions? Detailed source process inversions might be able to answer this question.

  2. Structural modification of Li[Li{sub 0.27}Co{sub 0.20}Mn{sub 0.53}]O{sub 2} by lithium extraction and its electrochemical property as the positive electrode for Li-ion batteries

    Energy Technology Data Exchange (ETDEWEB)

    Kumagai, Naoaki; Kim, Jung-Min; Tsuruta, Syo; Kadoma, Yoshihiro; Ui, Koichi [Department of Frontier Materials and Functional Engineering, Graduate School of Engineering, Iwate University, 4-3-5 Ueda, Morioka, Iwate 020-8551 (Japan)

    2008-06-30

    In our previous report, we have synthesized Li{sub 2}MnO{sub 3}-LiCoO{sub 2} solid solutions and have investigated electrochemical properties [J.-M. Kim, T. Sho, N. Kumagai, Electrochem. Commun. 9 (2007) 103]. These materials have showed a long charge plateau at above 4.5 V during the first charge, which disappears with the subsequent cycles. This phenomenon is usually observed in Li{sub 2}MnO{sub 3} and Li{sub 2}MnO{sub 3}-LiMeO{sub 2} system (Me = Ni{sub 1/2}Mn{sub 1/2} [Z. Lu, D.D. MacNeil, J.R. Dahn, Electrochem. Solid State Lett. 4 (2001) 191], Co [K. Numata, C. Sakaki, S. Yamanaka, Solid State Ionics 117 (1999) 257; Y.J. Park, Y.-S. Hong, X. Wu, M.K. Kim, K.S. Ryu, S.H. Chang, J. Electrochem. Soc. 151 (2004) A720], Fe [M. Tabuchi, A. Nakashima, H. Shigemura, K. Ado, H. Kobayashi, H. Sakaebe, H. Kageyama, T. Nakamura, M. Kohzaki, A. Hirano, R. Kanno, J. Electrochem. Soc. 149 (2002) A509], or Cr [B. Ammundsen, J. Paulsen, Adv. Mater. 13 (2001) 943]). In this study, we investigate the relationship between the first lithium extraction process and the electrochemical property of the synthesized Li[Li{sub 0.27}Co{sub 0.2}Mn{sub 0.53}]O{sub 2} material. The crystal structure and electrochemical performance of the synthesized Li[Li{sub 0.27}Co{sub 0.20}Mn{sub 0.53}]O{sub 2} are modified by the Li{sup +} extraction. (author)

  3. Tyrosine levels are associated with insulin resistance in patients with nonalcoholic fatty liver disease

    Directory of Open Access Journals (Sweden)

    Kawanaka M

    2015-06-01

    Full Text Available Miwa Kawanaka,1 Ken Nishino,1 Takahito Oka,1 Noriyo Urata,1 Jun Nakamura,1 Mitsuhiko Suehiro,1 Hirofumi Kawamoto,1 Yasutaka Chiba,2 Gotaro Yamada1 1Department of General Internal Medicine 2, Kawasaki Hospital, Kawasaki Medical School, Okayama, Japan; 2Clinical Research Center, Kinki University Hospital, Sayama, Japan Objective: Amino acid imbalance is often found in patients with cirrhosis, and this imbalance is associated with insulin resistance. However, the mechanism underlying the relationship between amino acid imbalance and insulin resistance remains unclear. We evaluated serum amino acid concentrations in patients with nonalcoholic fatty liver disease to determine if any of the levels of amino acids were associated with the biochemical markers and fibrosis stage of nonalcoholic steatohepatitis (NASH. Methods: In 137 patients with nonalcoholic fatty liver disease who underwent liver biopsy, plasma levels of branched-chain amino acid (BCAA, tyrosine (Tyr, and the BCAA-to-Tyr ratio values were determined using mass spectroscopy. These values were then assessed for associations with fibrosis stage, anthropometric markers (age, sex, and body mass index, biochemical markers (alanine aminotransferase, aspartate aminotransferase, γ-glutamyl transpeptidase, albumin, platelet count, total cholesterol, triglycerides, low-density lipoprotein cholesterol, and glycosylated hemoglobin, and relevant disease-specific biomarkers (homeostasis model assessment of insulin resistance [HOMA-IR], serum iron, ferritin, leptin, adiponectin, high-sensitivity C-reactive protein, and hyaluronic acid. Results: Serum albumin levels, plasma BCAA levels, and BCAA-to-Tyr ratio values were negatively associated with the fibrosis stage. In contrast, Tyr levels increased with increasing fibrotic staging. Tyr levels were also correlated with HOMA-IR results. Conclusion: Plasma BCAA levels in patients with NASH decreased with increasing liver fibrosis, while Tyr levels

  4. Comparison of DLK incidence after laser in situ keratomileusis associated with two femtosecond lasers: Femto LDV and IntraLase FS60

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    Tomita M

    2013-07-01

    Full Text Available Minoru Tomita,1–3 Yuko Sotoyama,1 Satoshi Yukawa,1 Tadayuki Nakamura1 1Shinagawa LASIK Center, Chiyoda-ku, Tokyo, Japan; 2Department of Ophthalmology, Wenzhou Medical College, Wenzhou, People’s Republic of China; 3Eye Can Cataract Surgery Center, Manila, Philippines Purpose: To compare the incidence of diffuse lamellar keratitis (DLK after laser in situ keratomileusis (LASIK with flap creation using the Femto LDV and IntraLase™ FS60 femtosecond lasers. Methods: A total of 818 consecutive myopic eyes had LASIK performed using either Femto LDV or IntraLase FS60 for flap creation. The same excimer laser, the Allegretto Wave® Eye-Q Laser, was used for correcting refractive errors for all patients. In the preoperative examination, uncorrected distance visual acuity, corrected distance visual acuity, and manifest refraction spherical equivalent were measured. At the postop examination, the same examinations were performed along with a slit-lamp biomicroscopic examination, and patients with DLK were classified into stages. For the statistical analysis of the DLK occurrence rate and the visual and refractive outcomes, the Mann-Whitney’s U-test was used. Results: In the Femto LDV group with 514 eyes, 42 (8.17% had DLK. In the IntraLase FS60 group with 304 eyes, 114 (37.5% had DLK. There was a statistically significant difference in the DLK incidence rate between these groups (P < 0.0001. Both groups had excellent visual and refractive outcomes. Although low levels of DLK were observed for both groups, they did not affect visual acuity. Conclusion: While there were significantly fewer incidences of low level DLK when using Femto LDV, neither femtosecond laser induced high levels of DLK, and any postoperative DLK cleared up within 1 week. Therefore, both lasers provide excellent results, with no clinical differences, and both excel at flap creation for LASIK. Keywords: LASIK, Ziemer, Femto LDV, DLK, IntraLase FS60, femtosecond laser

  5. Analysis shear wave velocity structure obtained from surface wave methods in Bornova, Izmir

    Energy Technology Data Exchange (ETDEWEB)

    Pamuk, Eren, E-mail: eren.pamuk@deu.edu.tr; Akgün, Mustafa, E-mail: mustafa.akgun@deu.edu.tr [Department of Geophysical Engineering, Dokuz Eylul University, Izmir (Turkey); Özdağ, Özkan Cevdet, E-mail: cevdet.ozdag@deu.edu.tr [Dokuz Eylul University Rectorate, Izmir (Turkey)

    2016-04-18

    Properties of the soil from the bedrock is necessary to describe accurately and reliably for the reduction of earthquake damage. Because seismic waves change their amplitude and frequency content owing to acoustic impedance difference between soil and bedrock. Firstly, shear wave velocity and depth information of layers on bedrock is needed to detect this changing. Shear wave velocity can be obtained using inversion of Rayleigh wave dispersion curves obtained from surface wave methods (MASW- the Multichannel Analysis of Surface Waves, ReMi-Refraction Microtremor, SPAC-Spatial Autocorrelation). While research depth is limeted in active source study, a passive source methods are utilized for deep depth which is not reached using active source methods. ReMi method is used to determine layer thickness and velocity up to 100 m using seismic refraction measurement systems.The research carried out up to desired depth depending on radius using SPAC which is utilized easily in conditions that district using of seismic studies in the city. Vs profiles which are required to calculate deformations in under static and dynamic loads can be obtained with high resolution using combining rayleigh wave dispersion curve obtained from active and passive source methods. In the this study, Surface waves data were collected using the measurements of MASW, ReMi and SPAC at the İzmir Bornova region. Dispersion curves obtained from surface wave methods were combined in wide frequency band and Vs-depth profiles were obtained using inversion. Reliability of the resulting soil profiles were provided by comparison with theoretical transfer function obtained from soil paremeters and observed soil transfer function from Nakamura technique and by examination of fitting between these functions. Vs values are changed between 200-830 m/s and engineering bedrock (Vs>760 m/s) depth is approximately 150 m.

  6. Chemical fractionation resulting from the hypervelocity impact process on metallic targets

    Science.gov (United States)

    Libourel, Guy; Ganino, Clément; Michel, Patrick; Nakamura, Akiko

    2016-10-01

    In a regime of hypervelocity impact cratering, the internal energy deposited in target + projectile region is large enough to melt and/or vaporize part of the material involved, which expands rapidly away from the impact site. Fast and energetic impact processes have therefore important chemical consequences on the projectile and target rock transformations during major impact events. Several physical and chemical processes occurred indeed in the short duration of the impact, e.g., melting, coating, mixing, condensation, crystallization, redox reactions, quenching, etc., all concurring to alter both projectile and target composition on the irreversible way.In order to document such hypervelocity impact chemical fractionation, we have started a program of impact experiments by shooting doped (27 trace elements) millimeter–sized basalt projectiles on metallic target using a two stages light gas gun. With impact velocity in the range from 0.25 to 7 km.s-1, these experiments are aimed i) to characterize chemically and texturally all the post-mortem materials (e.g., target, crater, impact melt, condensates, and ejectas), in order ii) to make a chemical mass balance budget of the process, and iii) to relate it to the kinetic energy involved in the hypervelocity impacts for scaling law purpose. Irrespective of the incident velocities, our preliminary results show the importance of redox processes, the significant changes in the ejecta composition (e.g., iron enrichment) and the systematic coating of the crater by the impact melt [1]. On the target side, characterizations of the microstructure of the shocked iron alloys to better constrain the shielding processes. We also show how these results have great implications in our understanding on the current surface properties of small bodies, and chiefly in the case of M-type asteroids. [1] Ganino C, Libourel G, Nakamura AM & Michel P (2015) Goldschmidt Abstracts, 2015 990.

  7. Relationship between quality of life and restless legs syndrome among a community-dwelling population in Japan

    Directory of Open Access Journals (Sweden)

    Kubo K

    2016-04-01

    Full Text Available Kazutoshi Kubo,1 Norio Sugawara,1,2 Ayako Kaneda,1 Ippei Takahashi,3 Kazuhiko Nakamura,1 Shigeyuki Nakaji,3 Norio Yasui-Furukori1 1Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki, 2Department of Psychiatry, Aomori Prefectural Center for Mental Health and Welfare, Aomori, 3Department of Social Medicine, Hirosaki University School of Medicine, Hirosaki, Japan Objectives: Restless legs syndrome (RLS is a sensorimotor disturbance that causes the production of impulses and dysesthesia and makes the patients feel as though they must move their lower extremities. Because the symptoms of RLS in the lower limbs tend to develop at night, RLS could cause sleep disorders. We investigated an association between the symptoms of RLS and the health-related quality of life among community-dwelling individuals in Japan. Methods: In this cross-sectional survey, we enrolled 985 volunteers who participated in the Iwaki Health Promotion Project in 2013. The symptoms of RLS were evaluated by the criteria of the International Restless Legs Syndrome Study Group. The assessments included an interview to obtain sociodemographic data, the second version of the Short Form Health Survey, the Center for Epidemiological Studies Depression scale, and the Pittsburgh Sleep Quality Index. A multiple regression analysis was used to assess the relationship between the symptoms of RLS and subscores of the Short Form Health Survey, Version 2. Results: The overall prevalence of RLS in our participants was 1.0%. We found a significant and negative association between symptoms of RLS and physical functioning, role – physical functioning, bodily pain, social functioning, and the physical composite summary score. Conclusion: After adjusting for confounders such as age, sex, and comorbidity, the burden of RLS appears to be mainly a physical problem. Impaired health-related quality of life among community individuals with RLS emphasizes the importance of

  8. Repeated-Sprint Sequences During Female Soccer Matches Using Fixed and Individual Speed Thresholds.

    Science.gov (United States)

    Nakamura, Fábio Y; Pereira, Lucas A; Loturco, Irineu; Rosseti, Marcelo; Moura, Felipe A; Bradley, Paul S

    2017-07-01

    Nakamura, FY, Pereira, LA, Loturco, I, Rosseti, M, Moura, FA, and Bradley, PS. Repeated-sprint sequences during female soccer matches using fixed and individual speed thresholds. J Strength Cond Res 31(7): 1802-1810, 2017-The main objective of this study was to characterize the occurrence of single sprint and repeated-sprint sequences (RSS) during elite female soccer matches, using fixed (20 km·h) and individually based speed thresholds (>90% of the mean speed from a 20-m sprint test). Eleven elite female soccer players from the same team participated in the study. All players performed a 20-m linear sprint test, and were assessed in up to 10 official matches using Global Positioning System technology. Magnitude-based inferences were used to test for meaningful differences. Results revealed that irrespective of adopting fixed or individual speed thresholds, female players produced only a few RSS during matches (2.3 ± 2.4 sequences using the fixed threshold and 3.3 ± 3.0 sequences using the individually based threshold), with most sequences composing of just 2 sprints. Additionally, central defenders performed fewer sprints (10.2 ± 4.1) than other positions (fullbacks: 28.1 ± 5.5; midfielders: 21.9 ± 10.5; forwards: 31.9 ± 11.1; with the differences being likely to almost certainly associated with effect sizes ranging from 1.65 to 2.72), and sprinting ability declined in the second half. The data do not support the notion that RSS occurs frequently during soccer matches in female players, irrespective of using fixed or individual speed thresholds to define sprint occurrence. However, repeated-sprint ability development cannot be ruled out from soccer training programs because of its association with match-related performance.

  9. Retraction statement: 'Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer' by Yuanfeng Zeng, Huijun Xie, Yudan Qiao, Jianmei Wang, Xiling Zhu, Guoyang He, Yuling Li, Xiaoli Ren, Feifei Wang, Li Liang and Yanqing Ding.

    Science.gov (United States)

    2016-07-01

    The above article in Cancer Science (doi: 10.1111/cas.12768), published online on 26 October 2015 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Yusuke Nakamura, and Wiley Publishing Asia Pty Ltd. The retraction has been agreed as Panels +C3 and +Y27632 of SW480 Mock shown in Figure 2a appear to have been taken from the same image, Panels + C3 and +Y27632 of HT29 FMNL2 shown in Figure 2a appear to have been taken from the same image, Panels shFMNL2-1 and shmDial1-1 in Figure 3a appear to have been taken from the same image, shFMNL2-2 and shmDial1-2 in Figure 3a appear to have been taken from the same image, Panels of shFMNL2-1 + shmDial1-1 and shFMNL2-1 + shmDial1-2 of +LPA appear to have been taken from the same image, gel bands of FLAG in Figure 4e appear to have been have been manipulated by erasing gel bands. Reference Zeng Y, Xie H, Qiao Y, Wang J, Zhu X, He G, Li Y, Ren X, Wang F, Liang L, Ding Y. Formin-like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer. Cancer Sci 2015; 106: 1385-93. doi: 10.1111/cas.12768.

  10. 17Beta-estradiol protects against oxidative stress-induced cell death through the glutathione/glutaredoxin-dependent redox regulation of Akt in myocardiac H9c2 cells.

    Science.gov (United States)

    Urata, Yoshishige; Ihara, Yoshito; Murata, Hiroaki; Goto, Shinji; Koji, Takehiko; Yodoi, Junji; Inoue, Satoshi; Kondo, Takahito

    2006-05-12

    The GSH/glutaredoxin (GRX) system is involved in the redox regulation of certain enzyme activities, and this system protects cells from H2O2-induced apoptosis by regulating the redox state of Akt (Murata, H., Ihara, Y., Nakamura, H., Yodoi, J., Sumikawa, K., and Kondo, T. (2003) J. Biol. Chem. 278, 50226-50233). Estrogens, such as 17beta-estradiol (E2), play an important role in development, growth, and differentiation and appear to have protective effects on oxidative stress mediated by estrogen receptor alpha (ERalpha). However, the role of the ERbeta-mediated pathway in this cytoprotection and the involvement of E2 in the redox regulation are not well understood. In the present study, we demonstrated that E2 protected cardiac H9c2 cells, expressing ERbeta from H2O2-induced apoptosis concomitant with an increase in the activity of Akt. E2 induced the expression of glutaredoxin (GRX) as well as gamma-glutamylcysteine synthetase, a rate-limiting enzyme for the synthesis of GSH. Inhibitors for both gamma-glutamylcysteine synthetase and GRX and ICI182,780, a specific inhibitor of ERs, abolished the protective effect of E2 on cell survival as well as the activity of Akt, suggesting that ERbeta is involved in the cytoprotection and redox regulation by E2. Transcription of the GRX gene was enhanced by E2. The promoter activity of GRX was up-regulated by an ERbeta-dependent element. These results suggest that the GRX/GSH system is involved in the cytoprotective and genomic effects of E2 on the redox state of Akt, a pathway that is mediated, at least in part, by ERbeta. This mechanism may also play an antiapoptotic role in cancer cells during carcinogenesis or chemotherapy.

  11. The Interstellar Gas Dust Streams and Seeds of Life

    Science.gov (United States)

    Oleg, Khavroshkin; Vladislav, Tsyplakov

    Gas dust Streams from Double Stars & Lunar Seismicity. The time series of seismic events were generated as follows: on the ordinate axis the peak amplitudes of events in standard units, on abscissa axis - seismogram durations of the same moonquakes and subsequent time intervals between them were used. Spectrum of the series disclosed time picks on hidden cosmological periodicities of lunar seismicity. A part of results (picks) presents orbital periods of double stars nearest to the Solar system. The explanation of that results is existing gas-dust streams from binary stars systems and interacting of it with lunar surface. Information content of the Nakamura`s Catalog of moonquakes is very rich: from solar-earth tides to clustering among the meteoroid streams [1, 2]. The histograms from meteoroid impacts seismic data revealed the seismic wave responses of the Moon to solar oscillations and the action on the lunar surface by dust-gas plasma of meteoroid streams [3]. The time series of seismic events were generated as follows: on an axis of ordinates - the peak amplitudes of events in standard units, on an abscissa - seismogram durations of the same moonquakes and subsequent time intervals between them were put aside [4]. Spectrum of the series of meteoroid streams seismicity disclosed time picks on orbital periods some planets and their satellites and solar oscillations [4, 5]. The research of peculiarities of histogram envelopes [3] and comparative common analysis solar bursts data and mass meteoroid distribution are confirmed [3, 4] and revealed Forbush`s effect for gas-dust plasma [6]. Hidden astrophysical periodicities of lunar seismicity were obtained early from an analysis of time series [7] which were similarity to series [4]. The path of results of [7] is presented in the Table where picks presents orbital periods of double stars nearest to the Solar system. Hypothesis for explanation of the Table results is existing gas-dust streams from binary stars near

  12. La pesquería de tiburones oceánicos-costeros en los litorales de Colima, Jalisco y Michoacán

    Directory of Open Access Journals (Sweden)

    Angélica Cruz

    2011-06-01

    Full Text Available La pesquería de tiburón es una de las más importantes en el Pacífico mexicano, en la actualidad no se cuentan con los datos de la composición específica de las capturas de las diferentes flotas. En el presente trabajo se describen aspectos biológicos-pesqueros de las especies de tiburón, capturadas por la flota palangrera de mediana altura del puerto de Manzanillo, en un periodo anual de abril 2006-abril 2007, los muestreos se realizaron mensualmente a bordo de estas embarcaciones. La composición de las capturas estuvo representada por nueve especies (n=1 962, de las cuales Carcharhinus falciformis (Bibron, 1839 (88.12% sostiene esta pesquería y en segundo lugar Prionace glauca (Linnaeus, 1758 (8.21%. Las especies poco frecuentes fueron Sphyrna zygaena (Linnaeus, 1758 con (1.78%, Alopias pelagicus (Nakamura, 1935 (0.82%, Carcharhinus longimanus (Poey, 1861 (0.45%, Alopias superciliosus (Lowe, 1839 (0.35%, Carcharhinus leucas (Valenciennes, 1839 (0.1%, Carcharhinus limbatus (Valenciennes, 1839 (0.1% é Isurus oxyrinchus (Rafinesque, 1810 (0.05%. La fecundidad estimada para C. falciformis fue de 3-7 crías/hembra con tallas de 30-45cm LT; 40.57+2.03cm LT y P. glauca con 5-52 crías/hembra, con tallas de 5-18.6cm LT; 11.61±0.21cm LT. Por lo tanto se asume que C. falciformis presenta un ciclo concurrente y P. glauca probablemente un ciclo bianual consecutivo.

  13. Epoprostenol sodium for treatment of pulmonary arterial hypertension

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    Saito Y

    2015-05-01

    Full Text Available Yukihiro Saito,1 Kazufumi Nakamura,1 Satoshi Akagi,1 Toshihiro Sarashina,1 Kentaro Ejiri,1 Aya Miura,1 Aiko Ogawa,2 Hiromi Matsubara,2 Hiroshi Ito1 1Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan; 2Division of Cardiology, National Hospital Organization Okayama Medical Center, Okayama, Japan Abstract: The release of endogenous prostacyclin (PGI2 is depressed in patients with pulmonary arterial hypertension (PAH. PGI2 replacement therapy by epoprostenol infusion is one of the best treatments available for PAH. Here, we provide an overview of the current clinical data for epoprostenol. Epoprostenol treatment improves symptoms, exercise capacity, and hemodynamics, and is the only treatment that has been shown to reduce mortality in patients with idiopathic PAH (IPAH in randomized clinical trials. We have reported that high-dose epoprostenol therapy (>40 ng/kg/min also results in marked hemodynamic improvement in some patients with IPAH. High-dose epoprostenol has a pro-apoptotic effect on PAH-PASMCs via the IP receptor and upregulation of Fas ligand (FasL in vitro. However, long-term intravenous administration of epoprostenol is sometimes associated with catheter-related infections and leads to considerable inconvenience for the patient. In the future, the development of new routes of administration or the development of powerful PGI2 analogs, IP-receptor agonists, and gene and cell-based therapy enhancing PGI2 production with new routes of administration is required. Keywords: pulmonary arterial hypertension, prostacyclin, apoptosis

  14. Higher lung accumulation of intravenously injected organic nanotubes

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    Maitani Y

    2013-01-01

    Full Text Available Yoshie Maitani,1 Yuri Nakamura,1 Masao Kon,1 Emi Sanada,1 Kae Sumiyoshi,1 Natsuki Fujine,1 Masumi Asakawa,2 Masaki Kogiso,2 Toshimi Shimizu21Institute of Medicinal Chemistry, Hoshi University, Tokyo, Japan; 2Nanotube Research Center (NTRC, National Institute of Advanced Industrial Science and Technology (AIST, Tsukuba, JapanAbstract: The size and shape of intravenously injected particles can affect their biodistribution and is of importance for the development of particulated drug carrier systems. In this study, organic nanotubes (ONTs with a carboxyl group at the surface, a length of approximately 2 µm and outer diameter of 70–90 nm, were injected intravenously into tumor-bearing mice. To use ONTs as drug carriers, the biodistribution in selected organs of ONTs postinjection was examined using irinotecan, as an entrapped water-soluble marker inside ONTs, and gadolinium-chelated ONT, as an ONT marker, and compared with that of a 3 µm fluorescently labeled spherical microparticle which was similar size to the length of ONTs. It was found that for irinotecan, its active metabolite and gadolinium-chelated ONTs were highly accumulated in the lung, but to a lower level in the liver and spleen. On the other hand, microparticles deposited less in the lung and more highly in the liver. Moreover, histologic examination showed ONTs distributed more in lung tissues in part, whereas microparticles were present in blood vessels postinjection. These preliminary results support the notion of using negatively charged ONTs as intravascular carriers to maximize accumulation in the lung whilst reducing sequestration by the liver and spleen. This finding suggested that ONTs are potential carriers for lung-targeting drug delivery.Keywords: organic nanotube, lung, biodistribution, microparticle, particle shape

  15. Association of microsatellite polymorphisms of the GPDS1 locus with normal tension glaucoma in the Japanese population

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    Kayo Nakamura

    2009-04-01

    Full Text Available Kayo Nakamura1*, Masao Ota2*, Akira Meguro1, et al1Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Departmentof Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, JapanBackground: To investigate whether the GPDS1 locus, a potential causative locus of pigment-dispersion syndrome, is associated with normal-tension glaucoma (NTG in Japanese patients. Materials and methods: We used polymerase chain reaction amplification with sequencespecific primers to analyze 20 polymorphic microsatellite markers in and around the GPDS1 locus with an automated DNA analyzer and automated fragment detection by fluorescent-based technology. The DNA samples used for these analyses were obtained from ethnicity- and gendermatched patients, including 141 Japanese patients with NTG and 101 healthy controls. Patients exhibiting a comparatively early onset were selected as this suggests that genetic factors may show stronger involvement.Results: One allele of D7S2462 exhibited a frequency that was significantly decreased in NTG cases compared to controls (P = 0.0013, Pc = 0.019, OR = 0.48, 95% CI = 0.30–0.75. Alleles at another six microsatellite loci were positively or negatively associated with NTG, but these associations did not retain statistical significance after Bonferroni correction (P < 0.05, Pc > 0.05.Conclusion: Our study showed a significant association between the GPDS1 locus and NTG, suggesting that there may be some genetic risk factor(s in the development of NTG.Keywords: microsatellite, normal tension glaucoma, glaucoma-related pigment dispersion syndrome, GPDS1, DPP6

  16. A population-based study of the stratum corneum moisture

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    Pires TF

    2016-04-01

    Full Text Available Thiago de Farias Pires,1 Ana Paula Azambuja,2 Andrea Roseli Vançan Russo Horimoto,1 Mary Sanae Nakamura,2 Rafael de Oliveira Alvim,1 José Eduardo Krieger,1 Alexandre Costa Pereira1 1Laboratory of Genetics and Molecular Cardiology, Heart Institute, University of São Paulo Medical School, 2Natura Innovation and Product Technology Ltd., Cajamar, SP, Brazil Background: The stratum corneum (SC has important functions as a bound-water modulator and a primary barrier of the human skin from the external environment. However, no large epidemiological study has quantified the relative importance of different exposures with regard to these functional properties. In this study, we have studied a large sample of individuals from the Brazilian population in order to understand the different relationships between the properties of SC and a number of demographic and self-perceived variables. Methods: One thousand three hundred and thirty-nine individuals from a rural Brazilian population, who were participants of a family-based study, were submitted to a cross-sectional examination of the SC moisture by capacitance using the Corneometer® CM820 and investigated regarding environmental exposures, cosmetic use, and other physiological and epidemiological measurements. Self-perception-scaled questions about skin conditions were also applied. Results: We found significant associations between SC moisture and sex, age, high sun exposure, and sunscreen use frequency (P<0.025. In specific studied sites, self-reported race and obesity were also found to show significant effects. Dry skin self-perception was also found to be highly correlated with the objective measurement of the skin. Other environmental effects on SC moisture are also reported. Keywords: investigative dermatology, stratum corneum moisture, Corneometer, sun exposure, familial data modeling

  17. Enhanced effect of fibroblast growth factor-2-containing dalteparin/protamine nanoparticles on hair growth

    Directory of Open Access Journals (Sweden)

    Takabayashi Y

    2016-05-01

    Full Text Available Yuki Takabayashi,1 Masaki Nambu,1 Masayuki Ishihara,2 Masahiro Kuwabara,1 Koichi Fukuda,2 Shingo Nakamura,2 Hidemi Hattori,2Tomoharu Kiyosawa1 1Department of Plastic and Reconstructive Surgery, 2Division of Biomedical Engineering, Research Institute, National Defense Medical College, Tokorozawa, Saitama, Japan Purpose: Although treatments for alopecia are in high demand, not all treatments are safe and reliable. Dalteparin/protamine nanoparticles (D/P NPs can effectively carry growth factors (GFs such as fibroblast GF (FGF-2. The purpose of this study was to identify the effects of FGF-2-containing D/P NPs (FGF-2&D/P NPs on hair growth.Patients and methods: In this study, the participants were 12 volunteers with thin hair. One milliliter of FGF-2 (100 ng/mL and D/P NPs (56 μg/mL was applied and massaged on the skin of the scalp by the participants twice a day. They were evaluated for 6 months. Participants were photographed using a digital camera for general observation and a hair diagnosis system for measuring hair diameter.Results: The mean diameter of the hairs was significantly higher following the application of FGF-2&D/P NPs for 6 months. Objective improvements in thin hair were observed in two cases. Nine participants experienced greater bounce and hair resilience.Conclusion: The transdermal application of FGF-2&D/P NPs to the scalp can be used as a new treatment for alopecia. Keywords: hair growth, dalteparin/protamine nanoparticles, fibroblast growth factor, transdermal application

  18. Three-Dimensional Structure and Low-Level Features of the North Pacific Storm Track from 1999 to 2005

    Institute of Scientific and Technical Information of China (English)

    FU Gang; BI Wei; GUO Jingtian

    2009-01-01

    A storm track is a region in which synoptic eddy activities are statistically most prevalent and intense. At daily weather charts, it roughly corresponds to the mean trajectories of cyclones and anticyclones. In this paper, the recent QuikSCAT (Quick Scatterometer) satellite sea winds data with a 0.5°×0.5° horizontal resolution, and the NCEP (National Centers for Environmental Prediction) 10-m height Gaussian grid wind data and pressure-level reanalysis data, are employed to document the spatial structure of the North Pacific storm track in winter (January) and summer (July) from 1999 to 2005. The results show that in winter the North Pacific storm track is stronger, and is located in lower latitudes with a distinct zonal distribution. In summer, it is weaker, and is located in higher latitudes. Based on the horizontal distributions of geopotential height variance at various levels, three-dimensional schematic diagrams of the North Pacific storm track in winter and summer are extracted and presented. Analyses of the QuikSCAT wind data indicate that this dataset can depict the low-level storm track features in detail. The double storm tracks over the Southern Oceans found by Nakamura and Shimpo are confirmed. More significantly, two new pairs of low-level storm tracks over the North Pacific and the North Atlantic are identified by using this high-resolution dataset. The pair over the North Pacific is focused in this paper, and is named as the "subtropical storm track" and the "subpolar storm track", respectively. Moreover, statistical analyses of cyclone and anticyclone trajectories in the winters of 1999 to 2005 reveal as well the existence of the low-level double storm tracks over the North Pacific.

  19. False Negative Rates of a Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates via Real-Time PCR

    Energy Technology Data Exchange (ETDEWEB)

    Hutchison, Janine R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Piepel, Gregory F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Amidan, Brett G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sydor, Michael A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Kaiser, Brooke L.D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-06-01

    Surface sampling for Bacillus anthracis spores has traditionally relied on detection via bacterial cultivation methods. Although effective, this approach does not provide the level of organism specificity that can be gained through molecular techniques. False negative rates (FNR) and limits of detection (LOD) were determined for two B. anthracis surrogates with modified rapid viability-polymerase chain reaction (mRV-PCR) following macrofoam-swab sampling. This study was conducted in parallel with a previously reported study that analyzed spores using a plate-culture method. B. anthracis Sterne (BAS) or B. atrophaeus Nakamura (BG) spores were deposited onto four surface materials (glass, stainless steel, vinyl tile, and plastic) at nine target concentrations (2 to 500 spores/coupon; 0.078 to 19.375 colony-forming units [CFU] per cm2). Mean FNR values for mRV-PCR analysis ranged from 0 to 0.917 for BAS and 0 to 0.875 for BG and increased as spore concentration decreased (over the concentrations investigated) for each surface material. FNRs based on mRV-PCR data were not statistically different for BAS and BG, but were significantly lower for glass than for vinyl tile. FNRs also tended to be lower for the mRV-PCR method compared to the culture method. The mRV-PCR LOD95 was lowest for glass (0.429 CFU/cm2 with BAS and 0.341 CFU/cm2 with BG) and highest for vinyl tile (0.919 CFU/cm2 with BAS and 0.917 CFU/cm2 with BG). These mRV-PCR LOD95 values were lower than the culture values (BAS: 0.678 to 1.023 CFU/cm2 and BG: 0.820 to 1.489 CFU/cm2). The FNR and LOD95 values reported in this work provide guidance for environmental sampling of Bacillus spores at low concentrations.

  20. Evaluating Composite Sampling Methods of Bacillus Spores at Low Concentrations

    Science.gov (United States)

    Hess, Becky M.; Amidan, Brett G.; Anderson, Kevin K.; Hutchison, Janine R.

    2016-01-01

    Restoring all facility operations after the 2001 Amerithrax attacks took years to complete, highlighting the need to reduce remediation time. Some of the most time intensive tasks were environmental sampling and sample analyses. Composite sampling allows disparate samples to be combined, with only a single analysis needed, making it a promising method to reduce response times. We developed a statistical experimental design to test three different composite sampling methods: 1) single medium single pass composite (SM-SPC): a single cellulose sponge samples multiple coupons with a single pass across each coupon; 2) single medium multi-pass composite: a single cellulose sponge samples multiple coupons with multiple passes across each coupon (SM-MPC); and 3) multi-medium post-sample composite (MM-MPC): a single cellulose sponge samples a single surface, and then multiple sponges are combined during sample extraction. Five spore concentrations of Bacillus atrophaeus Nakamura spores were tested; concentrations ranged from 5 to 100 CFU/coupon (0.00775 to 0.155 CFU/cm2). Study variables included four clean surface materials (stainless steel, vinyl tile, ceramic tile, and painted dry wallboard) and three grime coated/dirty materials (stainless steel, vinyl tile, and ceramic tile). Analysis of variance for the clean study showed two significant factors: composite method (pmethod compared to the SM-SPC and SM-MPC methods. RE with the MM-MPC method for concentrations tested (10 to 100 CFU/coupon) was similar for ceramic tile, dry wall, and stainless steel for clean materials. RE was lowest for vinyl tile with both composite methods. Statistical tests for the dirty study showed RE was significantly higher for vinyl and stainless steel materials, but lower for ceramic tile. These results suggest post-sample compositing can be used to reduce sample analysis time when responding to a Bacillus anthracis contamination event of clean or dirty surfaces. PMID:27736999

  1. Analysis of Tropical Cyclone Tracks in the North Indian Ocean

    Science.gov (United States)

    Patwardhan, A.; Paliwal, M.; Mohapatra, M.

    2011-12-01

    Cyclones are regarded as one of the most dangerous meteorological phenomena of the tropical region. The probability of landfall of a tropical cyclone depends on its movement (trajectory). Analysis of trajectories of tropical cyclones could be useful for identifying potentially predictable characteristics. There is long history of analysis of tropical cyclones tracks. A common approach is using different clustering techniques to group the cyclone tracks on the basis of certain characteristics. Various clustering method have been used to study the tropical cyclones in different ocean basins like western North Pacific ocean (Elsner and Liu, 2003; Camargo et al., 2007), North Atlantic Ocean (Elsner, 2003; Gaffney et al. 2007; Nakamura et al., 2009). In this study, tropical cyclone tracks in the North Indian Ocean basin, for the period 1961-2010 have been analyzed and grouped into clusters based on their spatial characteristics. A tropical cyclone trajectory is approximated as an open curve and described by its first two moments. The resulting clusters have different centroid locations and also differently shaped variance ellipses. These track characteristics are then used in the standard clustering algorithms which allow the whole track shape, length, and location to be incorporated into the clustering methodology. The resulting clusters have different genesis locations and trajectory shapes. We have also examined characteristics such as life span, maximum sustained wind speed, landfall, seasonality, many of which are significantly different across the identified clusters. The clustering approach groups cyclones with higher maximum wind speed and longest life span in to one cluster. Another cluster includes short duration cyclonic events that are mostly deep depressions and significant for rainfall over Eastern and Central India. The clustering approach is likely to prove useful for analysis of events of significance with regard to impacts.

  2. Inactivation of enzymes and oxidative modification of proteins by stimulated neutrophils.

    Science.gov (United States)

    Oliver, C N

    1987-02-15

    Differentiated, stimulated HL-60 cells and freshly isolated, stimulated neutrophils inactivate glutamine synthetase (L-glutamate:ammonia ligase (ADP-forming), EC 6.3.1.2) either inside or outside of Escherichia coli. Stimulated neutrophils also inactivate at least four endogenous enzymes which are inactivated by mixed-function oxidation (MFO) systems in vitro (L. Fucci, C.N. Oliver, M.J. Coon, and E.R. Stadtman (1983) Proc. Natl. Acad. Sci. USA 80, 1521-1525). The inactivation of glutamine synthetase by stimulated neutrophils exhibits characteristics similar to those previously described using both enzymic and nonenzymic MFO systems (R.L. Levine, C.N. Oliver, R.M. Fulks, and E.R. Stadtman (1981) Proc. Natl. Acad. Sci. USA 78, 2120-2124). Although the reaction occurs in the absence of Fe(III), it is stimulated by added Fe (III). Inactivation required molecular oxygen and is partially inhibited by Mn(II), catalase, superoxide dismutase, and metal chelators, ethylenediaminetetraacetic acid and o-phenanthroline. Both the kinetics and the extent of glutamine synthetase inactivation differ when neutrophils are stimulated with phorbol esters compared with formylated peptides. Glutamine synthetase inactivation catalyzed by MFO systems is accompanied by the formation of protein carbonyl derivatives which form stable hydrazones when treated with 2,4-dinitrophenylhydrazine. Multiple carbonyl derivatives are formed in the soluble protein fraction of stimulated neutrophils and these derivatives collectively exhibit an absorbance spectrum similar to that of glutamine synthetase inactivated by liver microsomal cytochrome P-450 MFO system (K. Nakamura, C.N. Oliver, and E.R. Stadtman (1985) Arch. Biochem. Biophys. 240, 319-329).

  3. Comparison of clinical features between primary and drug-induced sleep-related eating disorder

    Directory of Open Access Journals (Sweden)

    Komada Y

    2016-05-01

    Full Text Available Yoko Komada,1 Yoshikazu Takaesu,2 Kentaro Matsui,3 Masaki Nakamura,3 Shingo Nishida,3 Meri Kanno,3,† Akira Usui,3 Yuichi Inoue1,3 1Department of Somnology, 2Department of Psychiatry, Tokyo Medical University, 3Japan Somnology Center, Institute of Neuropsychiatry, Tokyo, Japan †Meri Kanno passed away on March 1, 2016 Purpose: The aim of this study was to ascertain the clinical characteristics of drug-induced sleep-related eating disorder (SRED. Patients and methods: We retrospectively reviewed the medical records of 30 patients with primary SRED (without any comorbid sleep disorders and who were not taking any possible causative medications, and ten patients with drug-induced SRED (occurrence of SRED episodes after starting nightly medication of sedative drugs, which completely resolved after dose reduction or discontinuation of the sedatives. Results: All patients with drug-induced SRED took multiple types of sedatives, such as benzodiazepines or benzodiazepine receptor agonists. Clinical features of drug-induced SRED compared with primary SRED were as follows: higher mean age of onset (40 years old in drug-induced SRED vs 26 years old in primary SRED, significantly higher rate of patients who had total amnesia during most of their SRED episodes (75.0% vs 31.8%, significantly lower rate of comorbidity of night eating syndrome (0% vs 63.3%, and significantly lower rate of history of sleepwalking (10.0% vs 46.7%. Increased doses of benzodiazepine receptor agonists may be responsible for drug-induced SRED. Conclusion: The clinical features of drug-induced SRED were different from those of primary SRED, possibly reflecting differences in the underlying mechanisms between these two categories of SREDs. Keywords: nocturnal eating syndrome, night eating, eating disorder, hypnotics, amnesia, sleepwalking, benzodiazepine

  4. Numerical relativity for D dimensional axially symmetric space-times: Formalism and code tests

    Science.gov (United States)

    Zilhão, Miguel; Witek, Helvi; Sperhake, Ulrich; Cardoso, Vitor; Gualtieri, Leonardo; Herdeiro, Carlos; Nerozzi, Andrea

    2010-04-01

    The numerical evolution of Einstein’s field equations in a generic background has the potential to answer a variety of important questions in physics: from applications to the gauge-gravity duality, to modeling black hole production in TeV gravity scenarios, to analysis of the stability of exact solutions, and to tests of cosmic censorship. In order to investigate these questions, we extend numerical relativity to more general space-times than those investigated hitherto, by developing a framework to study the numerical evolution of D dimensional vacuum space-times with an SO(D-2) isometry group for D≥5, or SO(D-3) for D≥6. Performing a dimensional reduction on a (D-4) sphere, the D dimensional vacuum Einstein equations are rewritten as a 3+1 dimensional system with source terms, and presented in the Baumgarte, Shapiro, Shibata, and Nakamura formulation. This allows the use of existing 3+1 dimensional numerical codes with small adaptations. Brill-Lindquist initial data are constructed in D dimensions and a procedure to match them to our 3+1 dimensional evolution equations is given. We have implemented our framework by adapting the Lean code and perform a variety of simulations of nonspinning black hole space-times. Specifically, we present a modified moving puncture gauge, which facilitates long-term stable simulations in D=5. We further demonstrate the internal consistency of the code by studying convergence and comparing numerical versus analytic results in the case of geodesic slicing for D=5, 6.

  5. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

    Science.gov (United States)

    Li, Yu; Xu, Shanqin; Giles, Amber; Nakamura, Kazuto; Lee, Jong Woo; Hou, Xiuyun; Donmez, Gizem; Li, Ji; Luo, Zhijun; Walsh, Kenneth; Guarente, Leonard; Zang, Mengwei

    2011-01-01

    Endoplasmic reticulum (ER) stress has been implicated in the pathophysiology of human type 2 diabetes (T2DM). Although SIRT1 has a therapeutic effect on metabolic deterioration in T2DM, the precise mechanisms by which SIRT1 improves insulin resistance remain unclear. Here, we demonstrate that adenovirus-mediated overexpression of SIRT1 in the liver of diet-induced insulin-resistant low-density lipoprotein receptor-deficient mice and of genetically obese ob/ob mice attenuates hepatic steatosis and ameliorates systemic insulin resistance. These beneficial effects were associated with decreased mammalian target of rapamycin complex 1 (mTORC1) activity, inhibited the unfolded protein response (UPR), and enhanced insulin receptor signaling in the liver, leading to decreased hepatic gluconeogenesis and improved glucose tolerance. The tunicamycin-induced splicing of X-box binding protein-1 and expression of GRP78 and CHOP were reduced by resveratrol in cultured cells in a SIRT1-dependent manner. Conversely, SIRT1-deficient mouse embryonic fibroblasts challenged with tunicamycin exhibited markedly increased mTORC1 activity and impaired ER homeostasi and insulin signaling. These effects were abolished by mTORC1 inhibition by rapamycin in human HepG2 cells. These studies indicate that SIRT1 serves as a negative regulator of UPR signaling in T2DM and that SIRT1 attenuates hepatic steatosis, ameliorates insulin resistance, and restores glucose homeostasis, largely through the inhibition of mTORC1 and ER stress.—Li, Y., Xu, S., Giles, A., Nakamura, K., Lee, J. W., Hou, X., Donmez, G., Li, J., Luo, Z., Walsh, K., Guarente, L., Zang, M. Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver. PMID:21321189

  6. Effect of Processing Conditions on the Anelastic Behavior of Plasma Sprayed Thermal Barrier Coatings

    Science.gov (United States)

    Viswanathan, Vaishak

    2011-12-01

    Plasma sprayed ceramic materials contain an assortment of micro-structural defects, including pores, cracks, and interfaces arising from the droplet based assemblage of the spray deposition technique. The defective architecture of the deposits introduces a novel "anelastic" response in the coatings comprising of their non-linear and hysteretic stress-strain relationship under mechanical loading. It has been established that this anelasticity can be attributed to the relative movement of the embedded defects under varying stresses. While the non-linear response of the coatings arises from the opening/closure of defects, hysteresis is produced by the frictional sliding among defect surfaces. Recent studies have indicated that anelastic behavior of coatings can be a unique descriptor of their mechanical behavior and related to the defect configuration. In this dissertation, a multi-variable study employing systematic processing strategies was conducted to augment the understanding on various aspects of the reported anelastic behavior. A bi-layer curvature measurement technique was adapted to measure the anelastic properties of plasma sprayed ceramic. The quantification of anelastic parameters was done using a non-linear model proposed by Nakamura et.al. An error analysis was conducted on the technique to know the available margins for both experimental as well as computational errors. The error analysis was extended to evaluate its sensitivity towards different coating microstructure. For this purpose, three coatings with significantly different microstructures were fabricated via tuning of process parameters. Later the three coatings were also subjected to different strain ranges systematically, in order to understand the origin and evolution of anelasticity on different microstructures. The last segment of this thesis attempts to capture the intricacies on the processing front and tries to evaluate and establish a correlation between them and the anelastic

  7. A Study on the Uncertainty of Flow-Induced Vibration in a Cross Flow over Staggered Tubes

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Ji-Su; Park, Jong-Woon [Dongguk univ, Gyeong Ju (Korea, Republic of); Choi, Hyeon-Kyeong [HanNam University, Daejeon (Korea, Republic of)

    2015-05-15

    Cross-flow in many support columns of very high temperature reactor (VHTR) lower plenum would have FIV issues under high speed flow jetting from the core. For a group of multiple circular cylinders subjected to a cross-flow, three types of potential vibration mechanisms may exist: (1) Vortex-induced vibration (VIV), (2) Fluid-elastic vibration (FEV) and (3) Turbulence-induced vibration (TIV). Kevalahan studied the free vibration of circular cylinders in a tightly packed periodic square inline array of cylinders. Pandey et al. studied the flue gas flow distribution in the Low Temperature Super Heater (LTSH) tube bundles situated in second pass of a utility boiler and the phenomenon of flow induced vibration. Nakamura et al. studied flow instability of cylinder arrays resembling U-bend tubes in steam generators. The FIV evaluation is usually performed with computational fluid dynamic (CFD) analysis to obtain unknown frequency of oscillation of the multiple objects under turbulent flow and thus the uncertainty residing in the turbulence model used should be quantified. In this paper, potential FIV uncertainty arising from the turbulence phenomena are evaluated for a typical cross flow through staggered tube bundles resembling the VHTR lower plenum support columns. Flow induced vibration (FIV) is one of the important mechanical and fatigue issues in nuclear systems. Especially, cross-flow in many support structures of VHTR lower plenum would have FIV issues under highly turbulent jet flows from the core. The results show that the effect of turbulence parameters on FIV is not negligible and the uncertainty is 5 to 10%. Present method can be applied to future FIV evaluations of nuclear systems. More extensive studies on flow induced vibration in a plant scale by using more rigorous computational methods are under way.

  8. Defensive function of persecutory delusion and discrepancy between explicit and implicit self-esteem in schizophrenia: study using the Brief Implicit Association Test

    Directory of Open Access Journals (Sweden)

    Nakamura M

    2014-12-01

    Full Text Available Mitsuo Nakamura,1 Tomomi Hayakawa,2 Aiko Okamura,3 Mutsumi Kohigashi,4 Kenji Fukui,1 Jin Narumoto1 1Department of Psychiatry, Graduate School of Medicine, Kyoto Prefectural University of Medicine, Kyoto, Japan; 2Gojouyama Hospital, Nara, Japan; 3Yashio Hospital, Saitama, Japan; 4Department of Psychiatry, Kyoto Second Red Cross Hospital, Kyoto, Japan Background: If delusions serve as a defense mechanism in schizophrenia patients with paranoia, then they should show normal or high explicit self-esteem and low implicit self-esteem. However, the results of previous studies are inconsistent. One possible explanation for this inconsistency is that there are two types of paranoia, “bad me” (self-blaming paranoia and “poor me” (non-self-blaming paranoia. We thus examined implicit and explicit self-esteem and self-blaming tendency in patients with schizophrenia and schizoaffective disorder. We hypothesized that patients with paranoia would show lower implicit self-esteem and only those with non-self-blaming paranoia would experience a discrepancy between explicit and implicit self-esteem. Methods: Participants consisted of patients with schizophrenia and schizoaffective disorder recruited from a day hospital (N=71. Participants were assessed for psychotic symptoms, using the Brief Psychiatric Rating Scale (BPRS, and self-blaming tendency, using the brief COPE. We also assessed explicit self-esteem, using the Rosenberg Self-Esteem Scale (RSES, implicit self-esteem, using Brief Implicit Association Test (BIAT, and discrepancy between explicit and implicit self-esteem. Results: Contrary to our hypothesis, implicit self-esteem in paranoia and nonparanoia showed no statistical difference. As expected, only patients with non-self-blaming paranoia experienced a discrepancy between explicit and implicit self-esteem; other groups showed no such discrepancy. Conclusion: These results suggest that persecutory delusion plays a defensive role in non

  9. Retraction statement: ‘Formin‐like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer’ by Yuanfeng Zeng, Huijun Xie, Yudan Qiao, Jianmei Wang, Xiling Zhu, Guoyang He, Yuling Li, Xiaoli Ren, Feifei Wang, Li Liang and Yanqing Ding

    Science.gov (United States)

    2016-01-01

    The above article in Cancer Science (doi: 10.1111/cas.12768), published online on 26 October 2015 in Wiley Online Library (http://wileyonlinelibrary.com), has been retracted by agreement between the authors, the journal Editor in Chief, Yusuke Nakamura, and Wiley Publishing Asia Pty Ltd. The retraction has been agreed as Panels +C3 and +Y27632 of SW480 Mock shown in Figure 2a appear to have been taken from the same image, Panels + C3 and +Y27632 of HT29 FMNL2 shown in Figure 2a appear to have been taken from the same image, Panels shFMNL2‐1 and shmDial1‐1 in Figure 3a appear to have been taken from the same image, shFMNL2‐2 and shmDial1‐2 in Figure 3a appear to have been taken from the same image, Panels of shFMNL2‐1 + shmDial1‐1 and shFMNL2‐1 + shmDial1‐2 of +LPA appear to have been taken from the same image, gel bands of FLAG in Figure 4e appear to have been have been manipulated by erasing gel bands. Reference ZengY , XieH , QiaoY , WangJ , ZhuX , HeG , LiY , RenX , WangF , LiangL , DingY . Formin‐like2 regulates Rho/ROCK pathway to promote actin assembly and cell invasion of colorectal cancer. Cancer Sci 2015; 106: 1385–93. doi: 10.1111/cas.12768 26258642 PMID:27420476

  10. Rogue waves: Classification, measurement and data analysis, and hyperfast numerical modeling

    Science.gov (United States)

    Osborne, A. R.

    2010-07-01

    The last twenty years has seen the birth and subsequent evolution of a fundamental new idea in nonlinear wave research: Rogue waves, freak waves or extreme events in the wave field dynamics can often be classified as coherent structure solutions of the requisite nonlinear partial differential wave equations (PDEs). Since a large number of generic nonlinear PDEs occur across many branches of physics, the approach is widely applicable to many fields including the dynamics of ocean surface waves, internal waves, plasma waves, acoustic waves, nonlinear optics, solid state physics, geophysical fluid dynamics and turbulence (vortex dynamics and nonlinear waves), just to name a few. The first goal of this paper is to give a classification scheme for solutions of this type using the inverse scattering transform (IST) with periodic boundary conditions. In this context the methods of algebraic geometry give the solutions of particular PDEs in terms of Riemann theta functions. In the classification scheme the Riemann spectrum fully defines the coherent structure solutions and their mutual nonlinear interactions. I discuss three methods for determining the Riemann spectrum: (1) algebraic-geometric loop integrals, (2) Schottky uniformization and (3) the Nakamura-Boyd approach. I give an overview of several nonlinear wave equations and graph some of their coherent structure solutions using theta functions. The second goal is to discuss how theta functions can be used for developing data analysis (nonlinear Fourier) algorithms; nonlinear filtering techniques allow for the extraction of coherent structures from time series. The third goal is to address hyperfast numerical models of nonlinear wave equations (which are thousands of times faster than traditional spectral methods).

  11. Influences of peers’ and family members’ body shapes on perception of body image and desire for thinness in Japanese female students

    Directory of Open Access Journals (Sweden)

    Mase T

    2015-06-01

    Full Text Available Tomoki Mase,1 Kumiko Ohara,2,3 Chiemi Miyawaki,4 Katsuyasu Kouda,5 Harunobu Nakamura2 1Department of Childhood Education, Kyoto Seibo College, Kyoto, Japan; 2Graduate School of Human Development and Environment, Kobe University, Kobe, Japan; 3Research Fellow of Japan Society for the Promotion of Science, Tokyo, Japan; 4Department of Early Childhood Education, Heian Jogakuin (St Agnes’ College, Kyoto, Japan; 5Department of Public Health, Kinki University Faculty of Medicine, Osakasayama, Japan Purpose: The present study investigated the influence of peers’ and family members’ body shapes on the perception of body image and desire for thinness in Japanese female students.Methods: The study included 342 female, Japanese university students between the ages of 18 years and 22 years. They completed an anonymous questionnaire, which included questions related to anthropometry and body perception. Eating behavior was assessed by the Japanese version of the Eating Attitude Test-26.Results: Many students overestimated their body shape (81.2% of underweight students and 74.6% of normal students and had a desire for thinness (41.0% of underweight students, 88.2% of normal students, and 100% of overweight students. One of the main reasons for the overestimation of their body shape was comparison with others. Participants who were interested in a friend’s body shape were almost three times more likely to have a desire for thinness than those who were not interested in a female friend’s body shape (odds ratio: 3.06, P=0.014.Conclusion: The results indicate a possibility that a female Japanese student’s young female friends’ body shapes, influences her desire for thinness or her perception of her own body shape. Keywords: body perception, body shape, desire for thinness, female students 

  12. Earthquake focal mechanisms and stress field in Si-chuan-Yunnan area determined using P wave po-larity and short period P and S waveform data

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@Based on waveform data, several methods to determine focal mechanisms of small earthquakes were developed since 1980. Kisslinger (1980) and Julian, Foulger (1996) proposed an approach to determine solution by using amplitude ratio of P and S wave. Schwartz (1995) devised a method to determine solutions by the use of polarity data and amplitudes of seismogram envelopes. Amplitudes of short period seismic waves propagating in an inhomogene-ous medium are sensitive to the variation in velocity and Q structure. Nakamura, et al (1999) took medium inhomo-geneity into account in determining focal mechanisms of small earthquakes using waveform data. If the locations of small earthquakes are concentrated in a small region, we can assume that the raypaths from the events to a given station are almost the same. So P and S wave attenuations are independent of event locations. In this case it is con-venient to determine focal mechanisms of these events by using short period P and S wave dataj. Focal mechanism solutions of small earthquakes in 5 regions, i.e., Rongchang, Mabian-Muchuan, Ya¢an, Baoxing and Mianzhu, which are covered by the Chengdu Telemetered Network, are obtained by analyzing the P polarity and short body wave amplitude data recorded in the network since 1992. According to the method proposed by Gephart and Forsyth (1984), based on well determined focal mechanism solutions in 15 sub-zones of Sichuan and Yunnan area, three principal stress tensors s1, s2, and s3, instead of averages of P, B, and T axis of the solutions, are determined to represent the regional stress field distribution.

  13. Reconnection of Magnetic Fields

    Science.gov (United States)

    Birn, J.; Priest, E. R.

    2007-01-01

    Preface; Part I. Introduction: 1.1 The Sun E. R. Priest; 1.2 Earth's magnetosphere J. Birn; Part II. Basic Theory of MHD Reconnection: 2.1 Classical theory of two-dimensional reconnection T. G. Forbes; 2.2 Fundamental concepts G. Hornig; 2.3 Three-dimensional reconnection in the absence of magnetic null points G. Hornig; 2.4 Three-dimensional reconnection at magnetic null points D. Pontin; 2.5 Three-dimensional flux tube reconnection M. Linton; Part III. Basic Theory of Collisionless Reconnection: 3.1 Fundamentals of collisionless reconnection J. Drake; 3.2 Diffusion region physics M. Hesse; 3.3 Onset of magnetic reconnection P. Pritchett; 3.4 Hall-MHD reconnection A. Bhattacharjee and J. Dorelli; 3.5 Role of current-aligned instabilities J. Büchner and W. Daughton; 3.6 Nonthermal particle acceleration M. Hoshino; Part IV. Reconnection in the Magnetosphere: 4.1 Reconnection at the magnetopause: concepts and models J. G. Dorelli and A. Bhattacharjee; 4.2 Observations of magnetopause reconnection K.-H. Trattner; 4.3 On the stability of the magnetotail K. Schindler; 4.4 Simulations of reconnection in the magnetotail J. Birn; 4.5 Observations of tail reconnection W. Baumjohann and R. Nakamura; 4.6 Remote sensing of reconnection M. Freeman; Part V. Reconnection in the Sun's Atmosphere: 5.1 Coronal heating E. R. Priest; 5.2 Separator reconnection D. Longcope; 5.3 Pinching of coronal fields V. Titov; 5.4 Numerical experiments on coronal heating K. Galsgaard; 5.5 Solar flares K. Kusano; 5.6 Particle acceleration in flares: theory T. Neukirch; 5.7 Fast particles in flares: observations L. Fletcher; 6. Open problems J. Birn and E. R. Priest; Bibliography; Index.

  14. Maspin expression and its clinicopathological significance in tumorigenesis and progression of gastric cancer

    Institute of Scientific and Technical Information of China (English)

    Meng-Chun Wang; Yan-Min Yang; Xiao-Han Li; Fang Dong; Yan Li

    2004-01-01

    AIM: To investigate maspin expression in tumorigenesis and progression of gastric cancer and to explore its relevant molecular mechanisms.METHODS: Formalin-fixed and paraffin-embedded tissues from normal mucosa (n=182), dysplasia (n=69), cancer (n=113) of the stomach were studied for maspin expression by immunohistochemistry. Microvessel density (MVD) in gastric cancer was labeled using anti-CD34 antibody. Maspin expression was compared with clinical parameters and MVD of tumors. Caspase-3 expression was also detected in gastric carcinoma by immunohistochemistry. The relationship between Caspase-3 and maspin expression was concerned as well.RESULTS: The positive rates of maspin expression were 79.8%(145/182), 75.4%(52/69) and 50.4%(57/113) in normal mucosa, dysplasia and cancer of the stomach,respectively. Cancer less frequently expressed maspin than normal mucosa and dysplasia (P<0.05). Maspin expression showed a significantly negative association with invasive depth, metastasis, Lauren's and Nakamura's classification (P<0.05), but not with tumor size, Borrmann's classification,growth pattern or TNM staging (P>0.05). The positive rate of Caspase-3 was significantly lower in gastric cancer than in normal gastric mucosa (P<0.05,32.7% vs 50.4%). It was noteworthy that maspin expression was negatively correlated with MVD, but positively correlated with expression of Caspase-3 in gastric cancer (P<0.05).CONCLUSION: Down-regulated maspin expression is a late molecular event in gastric carcinogenesis. Reduced expression of maspin contributes to progression of gastric cancer probably by inhibiting cell adhesion, enhancing cell mobility,decreasing cell apoptosis and facilitating angiogenesis.Additionally altered expression of maspin underlies the molecular mechanism of differentiation of gastric cancer and supports the different histogenetic pathways of intestinal and diffuse gastric cancers. Maspin expression can be considered as an effective and objective

  15. Influences of Fascicle Length During Isometric Training on Improvement of Muscle Strength.

    Science.gov (United States)

    Tanaka, Hiroki; Ikezoe, Tome; Umehara, Jun; Nakamura, Masatoshi; Umegaki, Hiroki; Kobayashi, Takuya; Nishishita, Satoru; Fujita, Kosuke; Araki, Kojiro; Ichihashi, Noriaki

    2016-11-01

    Tanaka, H, Ikezoe, T, Umehara, J, Nakamura, M, Umegaki, H, Kobayashi, T, Nishishita, S, Fujita, K, Araki, K, and Ichihashi, N. Influences of fascicle length during isometric training on improvement of muscle strength. J Strength Cond Res 30(11): 3249-3255, 2016-This study investigated whether low-intensity isometric training would elicit a greater improvement in maximum voluntary contraction (MVC) at the same fascicle length, rather than the joint angle, adopted during training. Sixteen healthy women (21.8 ± 1.5 years) were randomly divided into an intervention group and a control group. Before (Pre) and after (Post) training, isometric plantarflexion MVCs were measured every 10° through the range of ankle joint position from 20° dorsiflexion to 30° plantarflexion (i.e., 6 ankle angles). Medial gastrocnemius fascicle length was also measured at each position, using B-mode ultrasound under 3 conditions of muscle activation: at rest, 30%MVC at respective angles, and MVC. Plantarflexion resistance training at an angle of 20° plantarflexion was performed 3 days a week for 4 weeks at 30%MVC using 3 sets of twenty 3-second isometric contractions. Maximum voluntary contraction in the intervention group increased at 0 and 10° plantarflexion (0°; Pre: 81.2 ± 26.5 N·m, Post: 105.0 ± 21.6 N·m, 10°; Pre: 63.0 ± 23.6 N·m, Post: 81.3 ± 20.3 N·m), which was not the angle used in training (20°). However, the fascicle length adopted in training at 20° plantarflexion and 30%MVC was similar to the value at 0 or 10° plantarflexion at MVC. Low-intensity isometric training at a shortened muscle length may be effective for improving MVC at a lengthened muscle length because of specificity of the fascicle length than the joint angle.

  16. The Experimental Study on the Effect Calcitonin Gene-related Peptide on Bone Resorption Mediated by Interleukin-1

    Institute of Scientific and Technical Information of China (English)

    LIAN; Kai(

    2001-01-01

    [1]Suda T Udagawa I Nakamura T et al.Modulation of osteoclast? Differentiation by local factors.Bone 1995 17(suppl 2) :875[2]Kanehisa J Heersche J N M.Osteoclastic bone resorption:in vitro analysis of the rate of resorption and migration of individual osteoclasts.Bone 1988 9:73[3]高建军.破骨细胞成熟和活化以及骨吸收机制.内分泌学分册 1998 18(2):57[4]Cohen-Solal M E Granlet A M Denne M A et al.Peripheral blood monocyte culture supernatants of menopausel women can induce bone resorption:involvement of cytokines.J Clin Endocrinol Metab 1993 77:1648[5]Kimble R B Vannice J L Bloedow D C et al.Interleukin-1 receptor antagonist decreases bone loss and bone resorption in ovariectomized rats.J Clin Invest 1994 93:1959[6]Horowitz M C.Cytokines and estrogen in bone:Antiosteoporotic ettects.Science 1993 260:626[7]Thomson B M Saklatvala J Chambers T J et al.Osteoblasts mediate interleukin 1 stimulation of bone resorption by rat osteoclasts.J Exp Med 1986 164:104[8]Goltzman D Mitchell J.Interaction of calciton and CGRP at receptor sites in target tissue.Science 1985 227:1343[9]Millet I Vignery A.The neuropeptide CGRP inhibits TNF-α but poorly induces IL-6 production by fetal rat osteoblasts.Cytokine 1997 12(9):999[10]Taichman R S Hauschka P V.Effects of IL-1βand TNF-α on osteoblastic expression of osteocalcin and mineralized extracellular matrix in vitro.Inflammation.1992 16:587

  17. Excimer laser for the treatment of psoriasis: safety, efficacy, and patient acceptability

    Directory of Open Access Journals (Sweden)

    Abrouk M

    2016-12-01

    Full Text Available Michael Abrouk,1 Ethan Levin,2 Merrick Brodsky,1 Jessica R Gandy,1 Mio Nakamura,2 Tian Hao Zhu,3 Benjamin Farahnik,4 John Koo,2 Tina Bhutani2 1Irvine School of Medicine, Irvine, 2Department of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco, 3Department of Dermatology, University of Southern California Keck School of Medicine, Los Angeles, CA, 4Department of Dermatology, University of Vermont College of Medicine, Burlington, VT, USA Introduction: The 308 nm excimer laser is a widely used device throughout the field of dermatology for many diseases including psoriasis. Although the laser has demonstrated clinical efficacy, there is a lack of literature outlining the safety, efficacy, and patient acceptability of the excimer laser. Methods: A literature search on PubMed was used with combinations of the terms “excimer”, “excimer laser”, “308 nm”, “psoriasis”, “protocol”, “safety”, “efficacy”, acceptability”, “side effects”, and “dose”. The search results were included if they contained information pertaining to excimer laser and psoriasis treatment and description of the safety, efficacy, and patient acceptability of the treatment. Results: The 308 nm excimer laser is generally safe and well tolerated with minimal side effects including erythema, blistering, and pigmentary changes. It has a range of efficacies depending on the protocol used with several different treatment protocols, including the induration protocol, the minimal erythema dose protocol, and the newer minimal blistering dose protocol. Conclusion: Although the excimer laser is not a first-line treatment, it remains an excellent treatment option for psoriasis patients and has been demonstrated to be an effective treatment with little to no side effects. Keywords: excimer, laser, 308 nm, psoriasis, safety, efficacy

  18. EDITORIAL: Special issue containing papers presented at the 4th IAEA Technical Meeting on the Theory of Plasma Instabilities Special issue containing papers presented at the 4th IAEA Technical Meeting on the Theory of Plasma Instabilities

    Science.gov (United States)

    Itoh, K.; Wilson, H. R.

    2010-05-01

    The 4th IAEA technical meeting (TM) on the Theory of Plasma Instabilities was held in Kyoto, May 18th--20th 2009, following the first (Seeon), second (Trieste) and third (York) meetings in this series. This IAEA-TM was motivated by the recent advances in theoretical methodology, the rapid progress in observations of laboratory and astrophysical plasmas and the evolution of fusion research as we approach the ITER era. The international advisory committee (IAC) and local organizing committee (LOC), the members of which are listed below, collaborated to define the scope and the content of the scientific programme. Young scientists were actively encouraged to participate in this TM to help stimulate their future research careers and raise their international profiles. Through these young scientists, the IAEA-TM planned to identify the future directions of research. About 90 researchers, from 13 countries and the IAEA, participated in this IAEA-TM, with 72 scientific presentations. The talks and posters generated enthusiastic discussions, contributing to the vibrancy of the meeting. This special issue of Nuclear Fusion consists of a cluster of papers, reporting some of the main contributions to the IAEA-TM. The articles in this cluster are representative of the scientific width of presentations at the meeting, spanning topics from micro-turbulence to large-scale MHD dynamics and from transport to detailed analysis of diagnostics. They demonstrate the quality and depth of the research presented at the conference. List of IAC (alphabetical order): B. Breizman (USA), S. Guenter (Germany), T. S. Hahm (USA), K. Itoh (Japan, Chair of 2009), Ya. I. Kolesnichenko (Ukraine), A. G. Peeters (UK), H. Wilson (UK) List of LOC (alphabetical order): A. Fukuyama, R. Horiuchi, S.-I. Itoh, N. Kasuya, Y. Kishimoto (co-chair), K. Kusano, J. Li, K. Mima, S. Murakami, H. Naitou, N. Nakajima, Y. Nakamura, H. Ohtani, S. Okamura, T. Ozeki, S. Sudo (co-chair), H. Sugama, Y. Todo, S. Tokuda, S

  19. Photochemical dynamics of indolylmaleimide derivatives.

    Science.gov (United States)

    Murakami, Tatsuhiro; Nakazono, Manabu; Kondorskiy, Alexey; Ishida, Toshimasa; Nanbu, Shinkoh

    2012-08-28

    On-the-fly nonadiabatic ab initio molecular dynamics simulations have been carried out for three anionic species of indolylmaleimides (3-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione, IM) to clarify the mechanisms of photochemical reactions. The results are obtained for (i) a monovalent anion with a deprotonated indole NH group (IM(-)'), (ii) a monovalent anion with a deprotonated maleimide NH group (IM(-)'') and (iii) a divalent anion with doubly deprotonated indole and the maleimide NH groups (IM(2-)). Quantum chemical calculations are treated at the three state averaged complete-active space self-consistent field level for 6 electrons in 5 orbitals with the cc-pVDZ basis set (CAS (6, 5) SCF/cc-pVDZ). Molecular dynamics simulations are performed with electronically nonadiabatic transitions included using the Zhu-Nakamura version of the trajectory surface hopping (ZN-TSH) method. It is found that the nonadiabatic transitions occur accompanied by the stretching and shrinking motions of the N(7)-C(8) bond in the case of IM(-)' and the C(11)-N(12) bond in IM(2-) rather than the twisting motion of the dihedral angle. We also found that the ultrafast S(2)→ S(1) nonadiabatic transitions occur through the conical intersection (CoIn) right after photoexcitation to S(2) in IM(-)' and IM(2-). Furthermore, the S(1)→ S(0) nonadiabatic transitions are found to take place in IM(-)'. It is concluded that IM(2-) would mainly contribute to the photoemission, because the S(1)← S(0) and S(2)← S(0) transitions of IM(-)'' are dipole-forbidden transitions and, moreover, IM(2-) is found to be the only species to stay in the S(1) state without non-radiative decay.

  20. Analysis of macular cone photoreceptors in a case of occult macular dystrophy

    Directory of Open Access Journals (Sweden)

    Tojo N

    2013-05-01

    Full Text Available Naoki Tojo Tomoko Nakamura Hironori Ozaki Miyako Oka Toshihiko Oiwake Atsushi HayashiDepartment of Ophthalmology, University of Toyama, Toyama, JapanPurpose: To investigate changes in cone photoreceptors with adaptive optics (AO fundus imaging and spectral domain optical coherence tomography (SD-OCT in a case of occult macular dystrophy (OMD.Patient and methods: Both eyes of a 42-year-old woman diagnosed with OMD were examined. We used an AO fundus camera to obtain images of cone photoreceptors in the macula of the OMD subject and five healthy control subjects. Correlations between the AO images and the SD-OCT images were examined. Cone photoreceptors in eight areas in the macula of OMD and healthy control subjects were analyzed and compared.Results: SD-OCT showed a loss of the cone outer-segment tips line outside of the fovea in both eyes of the subject with OMD. The left eye with decreased visual acuity showed a discontinuous photoreceptor inner-segment and outer-segment line and cone outer-segment tips line at the fovea in SD-OCT and loss of cone mosaics as a dark spot in the AO image. In panoramic AO images and cone-density maps, less cone density was observed in a ring-like region outside the fovea than in the peripheral retina. In most of the areas examined, the cone densities were lower in the OMD eyes than in the healthy control eyes.Conclusions: Cone densities in the macula of the OMD patient were greatly decreased. AO images were found to be useful to evaluate morphologic changes in cone photoreceptors in patients with OMD.Keywords: occult macular dystrophy, adaptive optics, cone photoreceptor, cone analysis, optical coherence tomography

  1. Recollections of My Young Days

    Science.gov (United States)

    MITSUOKA, Tomotari

    2013-01-01

    I was bashful by nature. In elementary school, I was enthusiastic about painting pictures, posters, and calligraphy, and making butterfly specimens and models. When I entered the middle school of Seikei Gakuen, I was fortunate to have good teachers and friends. Prof. Kusatao Nakamura taught us the “Preciousness of the pureness of heart”, which is the principle of my life. After World War II, school classes reopened. I was deeply moved by the lecture of botany by Prof. Fumio Maekawa, and had a notion that I should like to make research my lifework. I went to high school and had the worries of my life. During that time, it was the book Gakusei ni atau by Prof. Eijirou Kawai, and a speech by Prof. Tadao Yanaihara, that sustained my heart. In 1953, I entered the postgraduate course of the University of Tokyo, and received the guidance of Prof. Yuichi Ochi. This matter was decisive for my life. First of all, I developed a new medium, BL agar, for culturing intestinal bacteria, and then I discovered that Bifidus bacteria was one of the predominant organisms in human adults. This discovery became the basis of my research until today. For two years from 1964, I studied abroad in Germany and made good friends, to whom I owe an inestimable debt of gratitude. After returning to Japan, I discovered a number of rules governing the intestinal ecosystem. Thus, a new interdisciplinary field, intestinal bacteriology, was established. Subsequently, I discovered the health effects of fermented milks and oligosaccharides and proposed “biogenics”. I firmly believe that the fruit of creation is granted as a result of endeavoring with a pure heart. PMID:24936370

  2. Recollections of my young days: -the pleasure of creation-.

    Science.gov (United States)

    Mitsuoka, Tomotari

    2013-01-01

    I was bashful by nature. In elementary school, I was enthusiastic about painting pictures, posters, and calligraphy, and making butterfly specimens and models. When I entered the middle school of Seikei Gakuen, I was fortunate to have good teachers and friends. Prof. Kusatao Nakamura taught us the "Preciousness of the pureness of heart", which is the principle of my life. After World War II, school classes reopened. I was deeply moved by the lecture of botany by Prof. Fumio Maekawa, and had a notion that I should like to make research my lifework. I went to high school and had the worries of my life. During that time, it was the book Gakusei ni atau by Prof. Eijirou Kawai, and a speech by Prof. Tadao Yanaihara, that sustained my heart. In 1953, I entered the postgraduate course of the University of Tokyo, and received the guidance of Prof. Yuichi Ochi. This matter was decisive for my life. First of all, I developed a new medium, BL agar, for culturing intestinal bacteria, and then I discovered that Bifidus bacteria was one of the predominant organisms in human adults. This discovery became the basis of my research until today. For two years from 1964, I studied abroad in Germany and made good friends, to whom I owe an inestimable debt of gratitude. After returning to Japan, I discovered a number of rules governing the intestinal ecosystem. Thus, a new interdisciplinary field, intestinal bacteriology, was established. Subsequently, I discovered the health effects of fermented milks and oligosaccharides and proposed "biogenics". I firmly believe that the fruit of creation is granted as a result of endeavoring with a pure heart.

  3. DJ-1 as a potential biomarker for the development of biocompatible multiwalled carbon nanotubes

    Directory of Open Access Journals (Sweden)

    Haniu H

    2011-11-01

    Full Text Available Hisao Haniu1, Tamotsu Tsukahara2, Yoshikazu Matsuda3, Yuki Usui4, Kaoru Aoki5, Masayuki Shimizu5, Nobuhide Ogihara5, Kazuo Hara5, Seiji Takanashi5, Masanori Okamoto5, Norio Ishigaki5, Koichi Nakamura5, Hiroyuki Kato5, Naoto Saito6 1Institute of Carbon Science and Technology, 2Department of Integrative Physiology and Bio-System Control, Shinshu University, Matsumoto, Nagano, 3Clinical Pharmacology Educational Center, Nihon Pharmaceutical University, Ina-machi, Saitama, 4Research Center for Exotic Nanocarbons, 5Department of Orthopaedic Surgery, 6Department of Applied Physical Therapy, Shinshu University School of Health Sciences, Shinshu University, Matsumoto, Nagano, Japan Background: In the present study, we investigated whether DJ-1 could serve as a biomarker for assessing the biocompatibility of multiwalled carbon nanotubes (MWCNTs, using the highly purified carbon nanotube, HTT2800. Methods: Using Western blot analysis, we determined DJ-1 protein levels in two different types of cells (one capable and the other incapable of HTT2800 endocytosis. Using quantitative real-time polymerase chain reaction, we also investigated the ability of purified nanotubes to alter DJ-1 mRNA levels. Results: We demonstrated that the DJ-1 protein concentration was reduced, regardless of the cytotoxic activity of intracellular HTT2800. Furthermore, HTT2800 decreased the DJ-1 mRNA levels in a dose-dependent manner. This decrease in DJ-1 mRNA levels was not observed in the case of Sumi black or cup-stacked carbon nanotubes. Conclusion: These data indicate that modification of DJ-1 expression is caused by the cell response to MWCNTs. We conclude that DJ-1 is a promising candidate biomarker for the development of biocompatible MWCNTs. Keywords: multiwalled carbon nanotubes, DJ-1 protein, Western blot, quantitative real-time polymerase chain reaction

  4. Hydrophilicity of quinolones is not an exclusive factor for decreased activity in efflux-mediated resistant mutants of Staphylococcus aureus.

    Science.gov (United States)

    Takenouchi, T; Tabata, F; Iwata, Y; Hanzawa, H; Sugawara, M; Ohya, S

    1996-08-01

    The elevated expression of the norA gene is responsible for efflux-mediated resistance to quinolones in Staphylococcus aureus (E.Y.W. Ng, M. Trucksis, and D.C. Hooper, Antimicrob. Agents Chemother. 38:1345-1355, 1994). For S. aureus transformed with a plasmid containing the cloned norA gene, SA113(pTUS20) (H. Yoshida, M. Bogaki, S. Nakamura, K. Ubukata, and M. Konno, J. Bacteriol. 172:6942-6949, 1990), and an overexpressed mutant, SA-1199B (G.W. Kaatz, S.M. Seo, and C.A. Ruble, J. Infect. Dis. 163:1080-1086, 1991), the MICs of norfloxacin increased 16 and 64 times compared with its MICs for the recipient and wild-type strains, SA113 and SA-1199, respectively. MICs of CS-940, however, increased only two and eight times, even though these two fluoroquinolones are similarly hydrophilic (apparent logPs of approximately -1). No good correlation was found, among 15 developed and developing quinolones, between the increment ratio in MICs and hydrophobicity (r = 0.61). Analysis of the quantitative structure-activity relationship among 40 fluoroquinolones revealed that the MIC increment ratio was significantly correlated with the bulkiness of the C-7 substituent and bulkiness and hydrophobicity of the C-8 substituent of fluoroquinolones (r = 0.87) and not with its molecular hydrophobicity (r = 0.47). Cellular accumulation of norfloxacin in SA-1199B was significantly lower than that in SA-1199, and it was increased by addition of carbonyl cyanide m-chlorophenyl hydrazone. On the other hand, accumulations of CS-940 in these strains were nearly identical, and they were not affected by addition of the protonophore.

  5. Effect of blonanserin on cognitive and social function in acute phase Japanese schizophrenia compared with risperidone

    Directory of Open Access Journals (Sweden)

    Hori H

    2014-03-01

    Full Text Available Hikaru Hori, Kenji Yamada, Dan Kamada, Yuka Shibata, Asuka Katsuki, Reiji Yoshimura, Jun NakamuraDepartment of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, JapanBackground: This study aims to determine the effectiveness of blonanserin (BNS on the cognitive and social functions of patients with schizophrenia compared with risperidone (RIS during acute-phase (8-week treatment.Methods: A total of 39 schizophrenia inpatients were included in this study. The subjects received either BNS (N=20 or RIS (N=19, and the clinical responses were evaluated periodically. The concomitant use of mood stabilizers was not allowed. Efficacy was assessed with the Positive and Negative Syndrome Scale for schizophrenia. Cognition was assessed using the Brief Assessment of Cognition in Schizophrenia, Japanese-language version. Social function was assessed using the Life Assessment Scale for the Mentally Ill.Results: For both groups, each assessment exhibited a decrease in the mean change from baseline on the Positive and Negative Syndrome Scale. The depression subscale was significantly improved in the BNS group compared with the RIS group at 8 weeks after administration. BNS improved verbal fluency and executive function (cognitive function and daily living and work skills (social function. Compared with the RIS group, BNS was observed to improve daily living.Conclusion: BNS may improve psychotic symptoms, cognitive function, and daily living in patients with acute-phase schizophrenia. BNS may be superior to RIS in the improvement of daily living.Keywords: risperidone, blonanserin, schizophrenia, cognitive function, social function, acute-phase

  6. Recovery Efficiency, False Negative Rate, and Limit of Detection Performance of a Validated Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates

    Energy Technology Data Exchange (ETDEWEB)

    Piepel, Gregory F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hutchison, Janine R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deatherage Kaiser, Brooke L [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Amidan, Brett G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sydor, Michael A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Barrett, Christopher A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-03-31

    The performance of a macrofoam-swab sampling method was evaluated using Bacillus anthracis Sterne (BAS) and Bacillus atrophaeus Nakamura (BG) spores applied at nine low target amounts (2-500 spores) to positive-control plates and test coupons (2 in. × 2 in.) of four surface materials (glass, stainless steel, vinyl tile, and plastic). Test results from cultured samples were used to evaluate the effects of surrogate, surface concentration, and surface material on recovery efficiency (RE), false negative rate (FNR), and limit of detection. For RE, surrogate and surface material had statistically significant effects, but concentration did not. Mean REs were the lowest for vinyl tile (50.8% with BAS, 40.2% with BG) and the highest for glass (92.8% with BAS, 71.4% with BG). FNR values ranged from 0 to 0.833 for BAS and 0 to 0.806 for BG, with values increasing as concentration decreased in the range tested (0.078 to 19.375 CFU/cm2, where CFU denotes ‘colony forming units’). Surface material also had a statistically significant effect. A FNR-concentration curve was fit for each combination of surrogate and surface material. For both surrogates, the FNR curves tended to be the lowest for glass and highest for vinyl title. The FNR curves for BG tended to be higher than for BAS at lower concentrations, especially for glass. Results using a modified Rapid Viability-Polymerase Chain Reaction (mRV-PCR) analysis method were also obtained. The mRV-PCR results and comparisons to the culture results will be discussed in a subsequent report.

  7. Mussel-inspired human gelatin nanocoating for creating biologically adhesive surfaces

    Directory of Open Access Journals (Sweden)

    Yang X

    2014-05-01

    Full Text Available Xi Yang,1,2 Liping Zhu,1 Seiichi Tada,1 Di Zhou,3 Takashi Kitajima,1 Takashi Isoshima,1 Yasuhiro Yoshida,1,4 Mariko Nakamura,1,5 Weiqun Yan,2 Yoshihiro Ito1,3 1Nano Medical Engineering Laboratory, RIKEN, Saitama, Japan; 2School of Pharmaceutical Sciences, Jilin University, Jilin, People’s Republic of China; 3Emergent Bioengineering Materials Research Team, RIKEN Center for Emergent Matter Science, Saitama, 4Department of Biomaterials and Bioengineering, Graduate School of Dental Medicine, Hokkaido University, Hokkaido, 5Dental Hygiene Program, Kibi International College, Okayama, Japan Abstract: Recombinant human gelatin was conjugated with dopamine using carbodiimide as a surface modifier. This dopamine-coupled human gelatin (D-rhG was characterized by 1H-nuclear magnetic resonance, mass spectroscopy, and circular dichroism. D-rhG-coated surface properties were analyzed by physicochemical methods. Additionally, cell attachment and growth on the modified surfaces was assessed using human umbilical endothelial cells. Binding of gelatin onto titanium was significantly enhanced by dopamine conjugation. The thickness of the D-rhG coating depended on the treatment pH; thicker layers were formed at higher pH values, with a maximum thickness of 30 nm. D-rhG enhanced the binding of collagen-binding vascular endothelial growth factor and cell adhesion as compared with gelatin alone, even at the same surface concentration. The D-rhG surface modifier enhanced substrate binding by creating an adhesive nanointerface that increased specific protein binding and cell attachment. Keywords: recombinant human gelatin, dopamine, natural catechols, cell adhesion, cell culture, titanium

  8. Nada: A new code for studying self-gravitating tori around black holes

    Science.gov (United States)

    Montero, Pedro J.; Font, José A.; Shibata, Masaru

    2008-09-01

    We present a new two-dimensional numerical code called Nada designed to solve the full Einstein equations coupled to the general relativistic hydrodynamics equations. The code is mainly intended for studies of self-gravitating accretion disks (or tori) around black holes, although it is also suitable for regular spacetimes. Concerning technical aspects the Einstein equations are formulated and solved in the code using a formulation of the standard 3+1 Arnowitt-Deser-Misner canonical formalism system, the so-called Baumgarte-Shapiro Shibata-Nakamura approach. A key feature of the code is that derivative terms in the spacetime evolution equations are computed using a fourth-order centered finite difference approximation in conjunction with the Cartoon method to impose the axisymmetry condition under Cartesian coordinates (the choice in Nada), and the puncture/moving puncture approach to carry out black hole evolutions. Correspondingly, the general relativistic hydrodynamics equations are written in flux-conservative form and solved with high-resolution, shock-capturing schemes. We perform and discuss a number of tests to assess the accuracy and expected convergence of the code, namely, (single) black hole evolutions, shock tubes, and evolutions of both spherical and rotating relativistic stars in equilibrium, the gravitational collapse of a spherical relativistic star leading to the formation of a black hole. In addition, paving the way for specific applications of the code, we also present results from fully general relativistic numerical simulations of a system formed by a black hole surrounded by a self-gravitating torus in equilibrium.

  9. Determinacion de periodos fundamentales del suelo mediante vibraciones ambientales en el municipio de Humacao, Puerto Rico

    Science.gov (United States)

    Cintron Aponte, Rommel

    La tecnica de Nakamura ha sido utilizada a nivel mundial para determinar periodos fundamentales del suelo. La tecnica consiste en calcular y graficar cocientes espectrales H/V de vibraciones ambientales registradas sobre el suelo. Mediciones de vibraciones ambientales fueron tomadas en 151 lugares dentro del municipio de Humacao, localizado al este de Puerto Rico. Los datos se procesaron utilizando espectros de Fourier y espectros de potencia. La tecnica fue validada al compararla con los resultados de cocientes espectrales H/V de registros de sismos debiles y tambien con una modelacion numerica realizada con datos de un ensayo "downhole". Las graficas de los cocientes espectrales H/V fueron divididas en casos y grupos, los cuales dependen de la facilidad para identificar el periodo fundamental pico y amplitudes en frecuencias menores de 1 Hz, respectivamente. Los resultados obtenidos con ambos espectros fueron comparados y se concluye que los mismos se complementan para proveer resultados mas confiables. Se crearon mapas de periodos fundamentales, factores de amplitud, isoperiodos y clasificacion sismica de sitio. Los mapas de isoperiodos fueron realizados en las zonas mas pobladas sobre depositos de suelo. El mapa de periodos fundamentales del suelo mostro buena correlacion con la geologia local. El mapa de clasificacion sismica derivado de periodos de sitio fue comparado con el mapa de clasificacion sismica derivado de barrenos geotecnicos. El mapa de clasificacion obtenido de periodos puede sobreestimar un poco algunas clasificaciones del suelo. Sin embargo, este mapa puede proveer un estimado aproximado de la velocidad de onda de corte promedio del suelo hasta una profundidad de 100 pies (30 metros).

  10. The role of midlatitude mixing barriers in creating the annual variation of total ozone in high northern latitudes

    Science.gov (United States)

    Gille, John; Karol, Svetlana; Kinnison, Douglas; Lamarque, Jean-Francois; Yudin, Valery

    2014-08-01

    Data from the HIgh Resolution Dynamics Limb Sounder (HIRDLS), the Microwave Limb Sounder (MLS), and the Whole Atmosphere Community Climate Model (WACCM) are used to investigate the annual variation of total column ozone in high northern latitudes. Downward transport of ozone-rich air by the residual mean circulation during autumn and winter bends ozone isopleths down and increases the high-latitude ozone amounts, leading to an ozone maximum at the end of the winter. During the summer months eddy mixing acts to restore pre-fall distributions of ozone. In this study the large-scale mixing in the lower stratosphere is analyzed using Nakamura's (1996) equivalent length formulation with observed and simulated ozone. The analysis of ozone mixing is performed in the tracer equivalent latitude-potential temperature coordinate system. Steep latitudinal gradients of ozone isopleths below about 500 K occur during the winter, where there are minima in the equivalent length, indicating barriers to mixing at 30°N-40°N. This transport barrier allows large ozone maxima to develop poleward of it. The barrier disappears over the summer, permitting latitudinal mixing of the high ozone air. Above 500 K mixing is more effective during the winter, so a large winter maximum does not occur. In both midlatitude and high latitude the lower stratospheric layer from 330 to 500 K doubles its ozone content from autumn to spring, compared with much smaller changes in the layer from 500 to 650 K. Our results confirm that the presence of the winter transport barrier in the lower stratosphere controls the seasonal variation of total ozone.

  11. Erythrodermic psoriasis: pathophysiology and current treatment perspectives

    Directory of Open Access Journals (Sweden)

    Singh RK

    2016-07-01

    Full Text Available Rasnik K Singh,1 Kristina M Lee,2 Derya Ucmak,2 Merrick Brodsky,3 Zaza Atanelov,4 Benjamin Farahnik,5 Michael Abrouk,3 Mio Nakamura,2 Tian Hao Zhu,6 Wilson Liao2 1Department of Medicine, University of California – Los Angeles, David Geffen School of Medicine, Los Angeles, 2Department of Dermatology, University of California – San Francisco, San Francisco, 3Department of Medicine, University of California – Irvine, School of Medicine, Irvine, CA, 4Department of Medicine, New York Medical College, Valhalla, NY, 5Department of Medicine, University of Vermont College of Medicine, Burlington, VT, 6Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA, USA Abstract: Erythrodermic psoriasis (EP is a rare and severe variant of psoriasis vulgaris, with an estimated prevalence of 1%–2.25% among psoriatic patients. The condition presents with distinct histopathologic and clinical findings, which include a generalized inflammatory erythema involving at least 75% of the body surface area. The pathogenesis of EP is not well understood; however, several studies suggest that the disease is associated with a predominantly T helper 2 (Th2 phenotype. Given the morbidity and potential mortality associated with the condition, there is a need for a better understanding of its pathophysiology. The management of EP begins with a comprehensive assessment of the patient’s presentation and often requires multidisciplinary supportive measures. In 2010, the medical board of the US National Psoriasis Foundation published consensus guidelines advocating the use of cyclosporine or infliximab as first-line therapy in unstable cases, with acitretin and methotrexate reserved for more stable cases. Since the time of that publication, additional information regarding the efficacy of newer agents has emerged. We review the latest data with regard to the treatment of EP, which includes biologic therapies such as ustekinumab and

  12. The role of the dorsoanterior striatum in implicit motivation: The case of the need for power

    Directory of Open Access Journals (Sweden)

    Oliver C Schultheiss

    2013-04-01

    Full Text Available Implicit motives like the need for power (nPower scale affective responses to need-specific rewards or punishments and thereby influence activity in motivational-brain structures. In this paper, we review evidence specifically supporting a role of the striatum in nPower. Individual differences in nPower predict (a enhanced implicit learning accuracy, but not speed, on serial-response tasks that are reinforced by power-related incentives (e.g., winning or losing a contest; dominant or submissive emotional expressions in behavioral studies and (b activation of the anterior caudate in response to dominant emotional expressions in brain imaging research. We interpret these findings on the basis of Hikosaka, Nakamura, Sakai, and Nakahara's (2002; Current Opinion in Neurobiology, 12(2, 217-222 model of central mechanisms of motor skill learning. The model assigns a critical role to the dorsoanterior striatum in dopamine-driven learning of spatial stimulus sequences. Based on this model, we suggest that the dorsoanterior striatum is the locus of nPower-dependent reinforcement. However, given the centrality of this structure in a wide range of motivational pursuits, we also propose that activity in the dorsoanterior striatum may not only reflect individual differences in nPower, but also in other implicit motives, like the need for achievement or the need for affiliation, provided that the proper incentives for these motives are present during reinforcement learning. We discuss evidence in support of such a general role of the dorsoanterior striatum in implicit motivation.

  13. Microsystem销售GibbsCAM软件

    Institute of Scientific and Technical Information of China (English)

    2008-01-01

    2008年7月10日,为工模具制造商和零部件制造商提供CAD/CAM完整解决方案的领导者Cimatron有限公司宣布,其子公司Microsystem Srl.公司将在意大利销售先进的加工软件解决方案GibbsCAM,并提供技术支持。GibbsCAM软件解决方案为加工、车、车铣复合、旋转铣削、墓石加工系统、线切割、多刀塔/多主轴机床等提供广泛的CNC编程功能。专门适用于制造业的建模功能性调谐,支持线框、曲面、实体等的创建和操作。GibbsCAM软件采用了直观用户界面,内置结合性与仿真功能,能使制造商提高生产力,提高对客户要求的反应速度。GibbsCAM软件支持先进的供应商的控制器和机床,包括GE Fanuc,Infimatic,西门子,Doosan Infracore,Haas,index,MAG Fadal,Matsuura,Mazak,三菱,Mori Seiki,Nakamura Tome和Tornos等。

  14. Impact of enzyme replacement therapy and hematopoietic stem cell transplantation in patients with Morquio A syndrome

    Directory of Open Access Journals (Sweden)

    Tomatsu S

    2015-04-01

    Full Text Available Shunji Tomatsu,1,2 Kazuki Sawamoto,1 Carlos J Alméciga-Díaz,3 Tsutomu Shimada,1 Michael B Bober,1 Yasutsugu Chinen,4 Hiromasa Yabe,5 Adriana M Montaño,6 Roberto Giugliani,7 Francyne Kubaski,1,8 Eriko Yasuda,1 Alexander Rodríguez-López,3 Angela J Espejo-Mojica,3 Oscar F Sánchez,9 Robert W Mason,1 Luis A Barrera,3 William G Mackenzie,1 Tadao Orii2 1Nemours/Alfred I duPont Hospital for Children, Wilmington, DE, USA; 2Department of Pediatrics, Gifu University, Gifu, Japan; 3Institute for the Study of Inborn Errors of Metabolism, School of Sciences, Pontificia Universidad Javeriana, Bogotá, Colombia; 4Department of Pediatrics, Faculty of Medicine, University of the Ryukyus, Okinawa, 5Department of Cell Transplantation and Regenerative Medicine, Tokai University School of Medicine, Isehara, Japan; 6Department of Pediatrics, Saint Louis University, St Louis, MO, USA; 7Medical Genetics Service/HCPA and Department of Genetics/UFRGS, Porto Alegre, Brazil; 8Department of Biological Sciences, University of Delaware, Newark, DE, 9School of Chemical Engineering, Purdue University, West Lafayette, IN, USA Abstract: Patients with mucopolysaccharidosis IVA (MPS IVA can present with systemic skeletal dysplasia, leading to a need for multiple orthopedic surgical procedures, and often become wheelchair bound in their teenage years. Studies on patients with MPS IVA treated by enzyme replacement therapy (ERT showed a sharp reduction on urinary keratan sulfate, but only modest improvement based on a 6-minute walk test and no significant improvement on a 3-minute climb-up test and lung function test compared with the placebo group, at least in the short-term. Surgical remnants from ERT-treated patients did not show reduction of storage materials in chondrocytes. The impact of ERT on bone lesions in patients with MPS IVA remains limited. ERT seems to be enhanced in a mouse model of MPS IVA by a novel form of the enzyme tagged with a bone

  15. Green tea catechins for well-being and therapy: prospects and opportunities

    Directory of Open Access Journals (Sweden)

    Miyoshi N

    2015-12-01

    Full Text Available Noriyuki Miyoshi,1 Monira Pervin,1 Takuji Suzuki,2 Keiko Unno,3 Mamoru Isemura,1 Yoriyuki Nakamura1 1School of Food and Nutritional Sciences, University of Shizuoka, Yada, Shizuoka, Japan; 2Faculty of Education, Art and Science, Yamagata University, Yamagata, Japan; 3School of Pharmaceutical Sciences, University of Shizuoka, Yada, Shizuoka, Japan Abstract: Tea is derived from the leaves and buds of Camellia sinensis (Theaceae plant, and is consumed worldwide. Green tea was discovered in the People's Republic of China approximately 3,000 BC. Lu Yu (733–803 published a book that describes the history of tea, the techniques, and utensils used for manufacturing, the method of preparation, and drinking of tea in the People's Republic of China. Green tea contains various components with specific health-promoting effects and is believed to exert protective effects against diseases such as cancer, obesity, diabetes, hepatitis, and neurodegenerative diseases. Of the various tea components, the polyphenol catechins have been the subject of extensive investigation. Among the catechins, (--epigallocatechin gallate has the strongest bioactivity in most cases. Caffeine induces alertness, decreases the sensation of fatigue, and has a diuretic effect. Theanine and -aminobutyric acid can lower the blood pressure and regulate brain function. Vitamin C exhibits antiscorbutic activity, prevents cataracts, and may boost the immune system. Majority of the scientific evidence based on cellular and animal experiments as well as a number of human epidemiological and intervention studies indicate that green tea and (--epigallocatechin gallate have beneficial health effects against various diseases. However, conflicting results have also been reported. Since confounding factors could affect the results, future studies should be designed to eliminate such factors for better understanding of the benefits of green tea on human health. Genetic and environmental factors

  16. COMT Val158Met, but not BDNF Val66Met, is associated with white matter abnormalities of the temporal lobe in patients with first-episode, treatment-naïve major depressive disorder: a diffusion tensor imaging study

    Directory of Open Access Journals (Sweden)

    Hayashi K

    2014-06-01

    Full Text Available Kenji Hayashi,1 Reiji Yoshimura,1 Shingo Kakeda,2 Taro Kishi,3 Osamu Abe,4 Wakako Umene-Nakano,1 Asuka Katsuki,1 Hikaru Hori,1 Atsuko Ikenouchi-Sugita,1 Keita Watanabe,2 Satoru Ide,2 Issei Ueda,2 Junji Moriya,2 Nakao Iwata,3 Yukunori Korogi,2 Marek Kubicki,5 Jun Nakamura1 1Department of Psychiatry, 2Department of Radiology, University of Occupational and Environmental Health, Kitakyushu, Japan; 3Department of Psychiatry, Fujita Health University, Toyoake, Japan; 4Department of Radiology, Nihon University School of Medicine, Tokyo, Japan; 5Psychiatry Neuroimaging Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA Abstract: We investigated the association between the Val158Met polymorphism of the catechol-O-methyltransferase (COMT gene, the Val66Met polymorphism of the brain-derived neurotrophic factor (BDNF gene, and white matter changes in patients with major depressive disorder (MDD and healthy subjects using diffusion tensor imaging (DTI. We studied 30 patients with MDD (17 males and 13 females, with mean age ± standard deviation [SD] =44±12 years and 30 sex- and age-matched healthy controls (17 males and 13 females, aged 44±13 years. Using DTI analysis with a tract-based spatial statistics (TBSS approach, we investigated the differences in fractional anisotropy, radial diffusivity, and axial diffusivity distribution among the three groups (patients with the COMT gene Val158Met, those with the BDNF gene Val66Met, and the healthy subjects. In a voxel-wise-based group comparison, we found significant decreases in fractional anisotropy and axial diffusivity within the temporal lobe white matter in the Met-carriers with MDD compared with the controls (P<0.05. No correlations in fractional anisotropy, axial diffusivity, or radial diffusivity were observed between the MDD patients and the controls, either among those with the BDNF Val/Val genotype or among the BDNF Met-carriers. These results suggest an association

  17. [Relationships between perception of Exercise Guidelines 2006, perception of other health promotion policies, and demographic variables].

    Science.gov (United States)

    Harada, Kazuhiro; Takaizumi, Kanae; Shibata, Ai; Oka, Koichiro; Nakamura, Yoshio

    2009-10-01

    According to the interim report of Healthy Japan 21, promoting Exercise Guideline 2006 is one important issue in the fields of physical activity and exercise. However, a previous study indicated that Japanese people rarely were aware of Exercise Guideline 2006 (Higo & Nakamura, 2008). The purpose of the present study was to identify characteristics of those who were aware of the guideline. The subjects were 1,613 Japanese adults (40.2 +/- 12.2 years) recruited by a Japanese social research company. The study designwas cross-sectional, using an internet questionnaire. Regarding the research items, the dependent variable was awareness of Exercise Guideline 2006, and the independent variables included awareness of other health promotion policies such as Healthy Japan 21, the Japanese Nutrition Balance Guide, and the Japanese national policy for preventing metabolic syndrome, as well as demographic variables (e.g., gender, age, BMI, hours per day spent watching TV watching and hours per day with internet usage). Logistic regression analysis was used for this research. Of all subjects, 12.3% answered that they were aware of Exercise Guideline 2006. Those over 50 years old (OR = 2.17; 95% CI = 1.11-4.22), having over 10 million household income (OR = 1.94; 99% CI = 1.05-3.61), an exercise habit (OR = 1.75; 95% CI = 1.07-2.86), an awareness of Healthy Japan 21 (OR = 23.60; 95% CI = 15.26-36.52), the Japanese Nutrition Balance Guide (OR = 5.52; 95% GCI = 3.01-10.13), and the Japanese national policy for preventing metabolic syndrome (OR = 3.41; 95% CI = 2.12-5.48) were significantly more likely to be aware of the guideline. Major findings of this study were: 1) older people are more aware of Exercise Guideline 2006 than their younger counterparts, although level of awareness was generally low; 2) for promotion of Exercise Guideline 2006, targeting those with a low educational background might not be a critical issue; and 3) awareness levels for Exercise Guideline 2006 and

  18. Evaluation of cone function by a handheld non-mydriatic flicker electroretinogram device

    Directory of Open Access Journals (Sweden)

    Nakamura N

    2016-06-01

    Full Text Available Natsuko Nakamura,1 Kaoru Fujinami,1 Yoshinobu Mizuno,2 Toru Noda,2 Kazushige Tsunoda11Laboratory of Visual Physiology, Division of Vision Research, National Institute of Sensory Organs, 2Department of Ophthalmology, National Hospital Organization, National Tokyo Medical Center, Tokyo, JapanPurpose: Full-field electroretinograms (ERGs are used to evaluate retinal function in patients with various types of hereditary and acquired retinal diseases. However, ERG recordings require relatively invasive procedures, including pupillary dilation and the use of contact lens electrodes. Thus, it would be helpful to have a simpler and noninvasive screening method. The purpose of this study was to determine whether a new, handheld, portable ERG device, RETeval™, can be used to screen patients for cone dysfunction.Patients and methods: Thirty-five eyes of 35 patients who had reduced cone responses ascertained by a conventional ERG system using contact lens electrodes were studied. The causative diseases included achromatopsia, cone dystrophy, cone-rod dystrophy, retinitis pigmentosa, choroidal dystrophy, autoimmune retinopathy, and Stargardt disease. The flicker ERGs were recorded with the RETeval™ under undilated conditions with skin electrodes (stimulus strength, 3.0 cd·s/m2; frequency, 28.3 Hz, and the responses were compared to that of 50 healthy eyes. The amplitudes and implicit times of the fundamental component of the flicker ERGs were analyzed in three age groups: Group A, ≤20 years; Group B, 21–40 years; and Group C, ≥41 years.Results: In all of the age groups, the amplitudes of the ERGs were significantly smaller and the implicit times significantly longer in patients with cone dysfunction than in the control eyes. All but one of the patients had flicker amplitudes lower than the mean −2.0 standard deviation of control eyes.Conclusion: The RETeval™ has a potential of being used to screen for cone dysfunction. The entire examination

  19. Tabulation of comet observations.

    Science.gov (United States)

    1991-07-01

    Concerning comets: 1957 III Arend-Roland, 1957 V Mrkos, 1958 III Burnham, 1959 III Bester-Hoffmeister, 1959 VI Alcock, 1959 VIII P/Giacobini-Zinner, 1960 I P/Wild 1, 1960 II Burnham, 1960 III P/Schaumasse, 1960 VIII P/Finlay, 1961 V Wilson-Hubbard, 1961 VIII Seki, 1962 III Seki-Lines, 1962 VIII Humason, 1963 I Ikeya, 1963 III Alcock, 1963 V Pereyra, 1964 VI Tomita-Gerber-Honda, 1964 VIII Ikeya, 1964 IX Everhart, 1979 X Bradfield, 1980 X P/Stephan-Oterma, 1980 XII Meier, 1980 XIII P/Tuttle, 1981 II Panther, 1982 I Bowell, 1982 IV P/Grigg-Skjellerup, 1982 VII P/d'Arrest, 1986 III P/Halley, 1987 IV Shoemaker, 1987 XII P/Hartley 3, 1987 XIX P/Schwassmann-Wachmann 2, 1987 XXIX Bradfield, 1987 XXX Levy, 1987 XXXII McNaught, 1987 XXXIII P/Borrelly, 1987 XXXVI P/Parker-Hartley, 1987 XXXVII P/Helin- Roman-Alu 1, 1988 III Shoemaker-Holt, 1988 V Liller, 1988 VIII P/Ge-Wang, 1988 XI P/Shoemaker-Holt 2, 1988 XIV P/Tempel 2, 1988 XV Machholz, 1988 XX Yanaka, 1988 XXI Shoemaker, 1988 XXIV Yanaka, 1989 III Shoemaker, 1989 V Shoemaker-Holt-Rodriquez, 1989 VIII P/Pons-Winnecke, 1989 X P/Brorsen-Metcalf, 1989 XI P/Gunn, 1989 XIII P/Lovas 1, 1989 XVIII McKenzie-Russell, 1989 XIX Okazaki-Levy-Rudenko, 1989 XX P/Clark, 1989 XXI Helin-Ronan-Alu, 1989 XXII Aarseth-Brewington, 1989h P/Van Biesbroeck, 1989t P/Wild 2, 1989u P/Kearns-Kwee, 1989c1 Austin, 1989e1 Skorichenko-George, 1990a P/Wild 4, 1990b Černis-Kiuchi-Nakamura, 1990c Levy, 1990e P/Wolf-Harrington, 1990f P/Honda-Mrkos-Pajdušáková, 1990g McNaught-Hughes, 1990i Tsuchiya-Kiuchi, 1990n P/Taylor, 1990ο P/Shoemaker-Levy 1, 1991a P/Metcalf-Brewington, 1991b Arai, 1991c P/Swift-Gehrels, 1991d Shoemaker-Levy, 1991e P/Shoemaker-Levy 3, 1991h P/Takamizawa, 1991j P/Hartley 1, 1991k P/Mrkos, 1991l Helin-Lawrence, 1991n P/Faye, 1991q P/Levy, 1991t P/Hartley 2, P/Encke, P/Schwassmann-Wachmann 1.

  20. Detection of directivity in seismic site response from microtremor spectral analysis

    Directory of Open Access Journals (Sweden)

    V. Del Gaudio

    2008-07-01

    Full Text Available Recent observations have shown that slope response to seismic shaking can be characterised by directional variations of a factor of 2–3 or larger, with maxima oriented along local topography features (e.g. maximum slope direction. This phenomenon appears influenced by slope material properties and has occasionally been detected on landslide-prone slopes, where a down-slope directed amplification could enhance susceptibility to seismically-induced landsliding. The exact conditions for the occurrence of directional amplification remain still unclear and the implementation of investigation techniques capable to reveal the presence of such phenomena is desirable. To this purpose we tested the applicability of a method commonly used to evaluate site resonance properties (Horizontal to Vertical Noise Ratio – HVNR or Nakamura's method as reconnaissance technique for the identification of site response directivity. Measurements of the azimuthal variation of H/V spectral ratios (i.e. between horizontal and vertical component of ambient microtremors were conducted in a landslide-prone study area of central Italy where a local accelerometric network had previously provided evidence of directivity phenomena on some slopes. The test results were compared with average H/V spectral ratios obtained for low-to-moderate earthquakes recorded by the accelerometric stations. In general, noise and seismic recordings provided different amplitudes of spectral ratios at similar frequencies, likely because of differences in signal and instrument characteristics. Nevertheless, both kinds of recordings showed that at sites affected by site response directivity major H/V peaks have orientations consistent (within 20°–30° with the direction of maximum shaking energy. Therefore, HVNR appears to be a promising technique for identifying seismic response directivity. Furthermore, in a comparative test conducted on a slope mantled in part by a deep-seated landslide

  1. Preface

    Science.gov (United States)

    Biefeld, Robert M.

    2017-04-01

    This special issue of the Journal of Crystal Growth collects some of the papers presented either orally or as posters at the 18th International Conference on Metalorganic Vapor Phase Epitaxy (ICMOVPE-XVIII) held at the Sheraton San Diego Hotel & Marina in San Diego, California, USA, from July 10 through July 15, 2016. This conference series was initiated in 1981 by the French in Ajaccio and is now held semi-annually with rotation between the USA, Asia, and Europe. The conference is pre-eminent in the field and the papers presented as well as those published in this volume represent the leading edge research in MOVPE done worldwide. This particular conference followed the earlier tradition in emphasizing semiconductor materials. The very successful program, which was organized by Andrew Allerman and Christine Wang, contained 219 papers which included 5 plenary speakers, the Harold M. Manasevit Young Investigator Award speech, 113 oral presentations, 6 rump session talks on future trends in industry, and 94 posters. The conference presentations were led off by Nobel Prize Winner Professor Shuji Nakamura talking about the invention of blue LEDs and the future of solid state lighting. There were ten session on III-nitride growth and devices, four sessions on nanostructures and their characterization, as well as sessions on photovoltaics, growth fundamentals, the growth of III-V's on Si and other materials. The conference brought together 255 participants from 26 countries including Australia, 1, Belgium, 3, Brazil, 1, Canada, 3, China, 11, Czech Republic, 5, Denmark, 2, France, 11, Germany, 41, Hong Kong, 3, India, 2, Ireland, 3, Italy, 1, Japan, 31, Netherlands, 1, Norway, 1, Poland, 2, Republic of Korea, 11, Russian Federation, 2, Saudi Arabia, 3, Spain, 3, Sweden, 2, Switzerland, 3, Taiwan, 12, the United Kingdom, 7, and the USA, 90. It is my pleasure to personally thank the Conference Organizing Committee, the MRS and the exhibitors and sponsors who helped to

  2. Symptom predictors of response to electroconvulsive therapy in older patients with treatment-resistant depression

    Directory of Open Access Journals (Sweden)

    Tominaga K

    2011-07-01

    Full Text Available Keiichiro Tominaga¹, Mioto Okazaki¹, Hisashi Higuchi¹, Itaru Utagawa¹, Etsuko Nakamura², Noboru Yamaguchi¹¹Department of Neuropsychiatry, St Marianna University School of Medicine, Miyamae-ku, Kawasaki City, Kanagawa, ²Tsurukawa Sanatorium Hospital, Machida City, Tokyo, JapanBackground: Electroconvulsive therapy (ECT has been used for treatment-resistant depression. However, predictors of response to ECT have not been adequately studied using the Montgomery and Åsberg Depression Rating Scale, especially in older patients with treatment-resistant depression.Methods: This study included 18 Japanese patients who fulfilled the Diagnostic and Statistical Manual of Mental Disorders Fourth Edition Text Revision criteria for a diagnosis of major depressive disorder or bipolar disorder with a current major depressive episode, and met the definition of treatment-resistant depression outlined by Thase and Rush, scoring ≥21 on the Montgomery and Åsberg Depression Rating Scale. The three-factor model of the Montgomery and Åsberg Depression Rating Scale was used for analysis. Factor 1 was defined by three items, factor 2 by four items, and factor 3 by three items, representing dysphoria, retardation, and vegetative symptoms, respectively. ECT was performed twice a week for a total of six sessions using a Thymatron System IV device with the brief pulse technique. Clinical responses were defined on the basis of a ≥50% decrease in total pretreatment Montgomery and Åsberg Depression Rating Scale scores.Results: The mean pretreatment factor 2 score for responders (n = 7 was significantly lower than that for nonresponders (n = 11. Furthermore, a significant difference in mean factor 3 score between responders and nonresponders was observed one week after six sessions of ECT, indicating a time lag of response. No significant differences were observed for age, number of previous episodes, and duration of the current episode between responders and

  3. Boron isotope systematics during magma-carbonate interaction: an experimental study from Merapi (Indonesia) and Vesuvius (Italy)

    Science.gov (United States)

    Deegan, F. M.; Jolis, E. M.; Troll, V. R.; Freda, C.; Whitehouse, M.

    2011-12-01

    mass transfer in subduction zones, where B is frequently employed as a tracer of deep crustal recycling [8]. [1] Chadwick et al. (2007) J. Petrol. 48, 1793-1812. [2] Deegan et al. (2010) J. Petrol. 51, 1027-1051. [3] Freda et al. (2010) Bull. Volcanol. 73, 241-256. [4] Jolis et al. (2011) in prep. [5] Leeman & Sisson (1996) Rev. Min. 33, 645-707. [6] Ishikawa & Nakamura (1993) Earth Planet Sci. Lett. 117, 567-580. [7] Deegan et al. (2011) Geology Today 27, 63-64. [8] Rose et al. (2001) Science 293, 281-283.

  4. PREFACE Surface Modifications of Diamond and Related Materials (Session D, E-MRS Spring Meeting)

    Science.gov (United States)

    Nebel, Christoph E.

    2010-11-01

    program in proposing invited speakers. Finally, our symposium would not have been successful without the strong involvement and implication of the EMRS headquarter especially P Siffert, T Lippert, S Schoeffter and C Kocher. They will all find here our sincere thanks. Christoph E Nebel (Chair) Fraunhofer-Institute for Applied Solid State Physics (IAF), Germany Takako Nakamura National Institute of Advanced Industrial Science and Technology (AIST), Japan Philippe Bergonzo CEA-LIST, France John Foord University of Oxford, United Kingdom Kian-Ping Loh National University of Singapore, Singapore

  5. Glucosamine-containing supplement improves locomotor functions in subjects with knee pain – a pilot study of gait analysis

    Directory of Open Access Journals (Sweden)

    Kanzaki N

    2016-06-01

    Full Text Available Noriyuki Kanzaki,1 Yuta Otsuka,1 Takayuki Izumo,1 Hiroshi Shibata,1 Hideyuki Nagao,2 Keita Ogawara,3 Hiroshi Yamada,3 Seiji Miyazaki,3 Yutaka Nakamura3 1Institute for Health Care Science, Suntory Wellness Ltd, Seika-cho, Soraku-gun, Kyoto, Japan; 2Research Institute of Sports Medical Science, Tokai University, Hiratsuka, Kanagawa, Japan; 3School of Physical Education, Tokai University, Hiratsuka, Kanagawa, Japan Background: Previously, we demonstrated that glucosamine-containing supplementation was effective for improving locomotor functions, especially walking speed. However, the biomechanical mechanism of efficacy has not been elucidated. This study aimed to address this challenge in subjects with knee pain, using a motion capture system. Methods: An open label study was conducted in 30 Japanese subjects with knee pain. The subjects were administered a daily supplement containing 1,200 mg of glucosamine hydrochloride, 60 mg of chondroitin sulfate, 45 mg of type II collagen peptides, 90 mg of quercetin glycosides, 10 mg of imidazole peptides, 1 mg of proteoglycan, and 5 µg of vitamin D (GCQID. The intervention continued for 16 weeks. Efficacy for locomotor functions involving the knee joint was evaluated mainly using the Japanese Knee Osteoarthritis Measure (JKOM and the 5-question Geriatric Locomotive Function Scale (GLFS-5. To examine the biomechanical mechanism of efficacy for locomotor functions, motions of subjects in a normal walking state were captured. Gait analysis was conducted and efficacy for gait parameters such as normal walking speed, stride length, cadence, and angle of soles was evaluated. Results: GCQID significantly improved total scores on the JKOM and GLFS-5. In gait analysis, normal walking speed, stride length, and angle of soles at the end of the stance phase were all significantly increased, but cadence did not change significantly during the intervention period. There were significant intercorrelations of changes in

  6. Investigations Into Early Magnitude Estimation From Predominant Period, Using Synthetic Rupture Models

    Science.gov (United States)

    Hildyard, M.; Rietbrock, A.

    2007-12-01

    Considerable interest has been shown in a method for estimating predominant period in the time domain (TpMax), first proposed by Nakamura (1988) and currently being developed for other early warning systems (e.g. Lockman and Allen, BSSA, 2005). Issues still exist as to the causes of the scatter evident in empirical work, and how effective the method is for characterising large events whose time to rupture is longer than the few seconds desired to estimate the magnitude. Our work on applying this method to an aftershock dataset motivated us to investigate the method through the use of synthetic rupture models. The rupture model we use prescribes a stress-drop with a prescribed rise-time over a small patch of the fault surface. This stress-drop is propagated to other patches of the fault according to a prescribed rupture rate. The same finite difference model geometry and fault patch size was then used to model events ranging from magnitude 3.7 to 7.2. Moment Magnitude was calculated directly by integrating the resultant slip on the fault, and TpMax was calculated from seismograms recorded on surface 50 km from the centre of the fault. The initial modelling used a homogenous stress drop, rise-time, and rupture rate. A dataset of 165 events, showed a significant increasing relationship between the TpMax calculation and magnitude. Isolating similar events initiating at the same point on the fault, gave a near straight-line trend. Scatter in the relationship is shown to result from variations in the position, initiation point, stress drop, rise time, and rupture velocity. Low frequency filtering was found to significantly affect the TpMax calculations and trends. Without filtering, the relationship saturated from just after magnitude 6, as the time to rupture becomes longer than the window used to calculate TpMax. However, low frequency filtering actually reduces the time to reach a maximum in the calculation, and this can cause the increasing trend to continue into

  7. Dense Ocean Floor Network for Earthquakes and Tsunamis; DONET/ DONET2, Part2 -Development and data application for the mega thrust earthquakes around the Nankai trough-

    Science.gov (United States)

    Kaneda, Y.; Kawaguchi, K.; Araki, E.; Matsumoto, H.; Nakamura, T.; Nakano, M.; Kamiya, S.; Ariyoshi, K.; Baba, T.; Ohori, M.; Hori, T.; Takahashi, N.; Kaneko, S.; Donet Research; Development Group

    2010-12-01

    Yoshiyuki Kaneda Katsuyoshi Kawaguchi*, Eiichiro Araki*, Shou Kaneko*, Hiroyuki Matsumoto*, Takeshi Nakamura*, Masaru Nakano*, Shinichirou Kamiya*, Keisuke Ariyoshi*, Toshitaka Baba*, Michihiro Ohori*, Narumi Takakahashi*, and Takane Hori** * Earthquake and Tsunami Research Project for Disaster Prevention, Leading Project , Japan Agency for Marine-Earth Science and Technology (JAMSTEC) **Institute for Research on Earth Evolution, Japan Agency for Marine-Earth Science and Technology (JAMSTEC) DONET (Dense Ocean Floor Network for Earthquakes and Tsunamis) is the real time monitoring system of the Tonankai seismogenic zones around the Nankai trough southwestern Japan. We were starting to develop DONET to perform real time monitoring of crustal activities over there and the advanced early warning system. DONET will provide important and useful data to understand the Nankai trough maga thrust earthquake seismogenic zones and to improve the accuracy of the earthquake recurrence cycle simulation. Details of DONET concept are as follows. 1) Redundancy, Extendable function and advanced maintenance system using the looped cable system, junction boxes and the ROV/AUV. DONET has 20 observatories and incorporated in a double land stations concept. Also, we are developed ROV for the 10km cable extensions and heavy weight operations. 2) Multi kinds of sensors to observe broad band phenomena such as long period tremors, very low frequency earthquakes and strong motions of mega thrust earthquakes over M8: Therefore, sensors such as a broadband seismometer, an accelerometer, a hydrophone, a precise pressure gauge, a differential pressure gauge and a thermometer are equipped with each observatory in DONET. 3) For speedy detections, evaluations and notifications of earthquakes and tsunamis: DONET system will be deployed around the Tonankai seismogenic zone. 4) Provide data of ocean floor crustal deformations derived from pressure sensors: Simultaneously, the development of data

  8. Insomnia in patients on hemodialysis for a short versus long duration

    Directory of Open Access Journals (Sweden)

    Tomita T

    2016-09-01

    Full Text Available Tetsu Tomita,1 Norio Yasui-Furukori,1 Masaki Oka,1 Takaaki Shimizu,2 Aya Nagashima,2 Kento Mitsuhashi,2 Hisao Saito,3 Kazuhiko Nakamura1 1Department of Neuropsychiatry, Graduate School of Medicine, 2School of Medicine, Hirosaki University, 3Department of Urology, Oyokyo Kidney Research Institute, Hirosaki, Japan Background: Many studies have investigated insomnia and the factors associated with this condition in hemodialysis (HD patients, although the influence of HD duration has not been thoroughly investigated. In the present study, we investigated the factors, especially the duration of HD, associated with insomnia in HD patients.Patients and methods: A total of 138 patients undergoing HD were recruited, and the Japanese version of the Pittsburgh Sleep Quality Index (PSQI was used to assess the quality of sleep. Subjects with a total PSQI score up to 4 and those with a score of at least 5 were identified as normal subjects and subjects with insomnia, respectively. Additionally, we assessed restless legs syndrome, depression using the Center for Epidemiologic Studies Depression Scale, and health-related quality of life (QOL using the Short Form 8 Health Survey. We divided the subjects into two groups according to the median HD duration.Results: The prevalence rate of insomnia was 54.3% among all the subjects. Twenty-one subjects (15.2% had depression, 26 (18.8% had restless legs syndrome, and 75 (54.3% had insomnia. The median HD duration was 4 years. The scores of components 1 and 4 of the PSQI, subjective sleep quality and habitual sleep efficiency, did not show a significant difference between the normal and insomnia groups. The score of component 7, daytime dysfunction, showed a significant difference between the short and long HD duration groups. In multiple regression analysis, the score of the Short Form 8 Health Survey showed a significant association with the PSQI score in the long HD duration group, but no variable showed a

  9. Tsunami preparedness at the resort facilities along the coast of the Ryukyu Islands - their actions against the 27 February 2010 Okinawan and Chilean tsunami warning

    Science.gov (United States)

    Matsumoto, T.

    2010-12-01

    The economy (including tourism) in tropical and subtropical coastal areas, such as Okinawa Prefecture (Ryukyu) is highly relying on the sea. The sea has both “gentle” side to give people healing and “fierce” side to kill people. If we are going to utilise the sea for marine tourism such as constructing resort facilities on the oceanfront, we should know the whole nature of the sea, Tsunami is the typical case of the “fierce” side of the sea. We have already learned a lesson about this issue from the Sumatra tsunami in 2004. Early morning (5:31 am Japanese Standard Time = JST) on 27 February 2010, a M6.9 earthquake occurred near the coast of Okinawa Ryukyu Island Japan, and just after that Japanese Meteorological Agency (JMA) issued a tsunami warning along the coastal area of Okinawa Prefecture. About one hour later the tsunami warning was cancelled. The CMT solution of this earthquake was found to be strike-slip type with NE-SW P-axis. Therefore this did not induce a tsunami. However, in the afternoon on the same day (JST) a M8.6 earthquake occurred off the coast of Chile and soon after that a tsunami warning issued along the Pacific coastal area including Japan and Ryukyu Islands. Indeed maximum 1m tsunami hit the eastern coast of Okinawa Island on 28th February (Nakamura, 2010, personal communication). The author conducted a survey about the actions against the both tsunami after the 27 February tsunami warming to the major resort hotels along the coast of the Ryukyu Islands. A questionnaire was sent to about 20 hotels and 6 hotels replied to the questionnaire. Most of these hotels reported the regular training against tsunami attack, preparation of a disaster prevention manual, close communication with the local fire station authority, evacuation procedure towards high stories of the hotel building etc. It was “winter season” when the tsunami took place. However, if that were “summer season,” the other problem such as how they make the people

  10. Which articles and which topics in the forensic sciences are most highly cited?

    Science.gov (United States)

    Jones, A W

    2005-01-01

    Forensic science is a multidisciplinary field, which covers many branches of the pure, the applied and the biomedical sciences. Writing-up and publishing research findings helps to enhance the reputation of the investigators and the laboratories where the work was done. The number of times an article is cited in the reference lists of other articles is generally accepted as a mark of distinction. Indeed, citation analysis has become widely used in research assessment of individual scientists, university departments and entire nations. This article concerns the most highly cited papers published in the Journal of Forensic Sciences (JFS) between 1956 and 2005. These were identified with the help of Web-of-Science, which is the on-line version of Science Citation Index, produced by Thomson Institute for Scientific Information (Thomson ISI) with head offices in Philadelphia, USA. This database tracks, among other things, the annual citation records of articles published in several thousand scientific journals worldwide. Those JFS articles accumulating 50 or more citations were identified and rank-ordered according to the total number of citations. These articles were also evaluated according to the name of first author, the subject category of the article, the country of origin and the pattern of co-authorship. This search strategy located 46 articles cited between 50 and 292 times since they first appeared in print. The most highly cited paper by far was by Kasai, Nakamura and White (USA and Japan) concerning DNA profiling and the application of the polymerase chain reaction (PCR) in forensic science. Some forensic scientists appeared as first author on two to three highly cited articles, namely Wetli (USA), Budowle (USA) and Comey (USA). When the highly cited articles were sub-divided into subject category, 15 were identified as coming from toxicology, closely followed by criminalistics (14 articles), pathology (nine articles), physical anthropology (five articles

  11. The impact of tidal mixing at the Kuril Straits on the North Pacific: Part 2, Thermohaline adjustment of the intermediate layer

    Science.gov (United States)

    Toyoda, T.; Nakamura, T.; Ishikawa, Y.; Awaji, T.

    2003-04-01

    Recent studies show the importance of strong mixing at the Kuril Straits in freshning the intermediate layer to supply the low salinity water required for the production of the North Pacific Intermediate Water (NPIW) which is distributed over the entire subtropical gyre [Talley, 1991]. Nakamura et al.(2000; 2003) indicate that the strong vertical mixing is driven by a swift tidal flow and suggest that it has the ability to change the fluxes of potential vorticity (PV) and other water properties from the Okhotsk Sea to the North Pacific. Such an effect of tidal mixing at the western boundary is expected to affect the subarctic circulation based on the ventilated thermocline theory [Pedlosky, 1996], as well as the subsurface circulation in the subtropical region. In order to assess the impacts of tidal mixing at the Kurils on the circulation of the North Pacifc, a set of experiments are performed using a global ocean general circulation model. The Okhotsk Sea water flowing into the intermediate layer of the North Pacific becomes colder and fresher at the Kurils by strong vertical mixing. This enhances the supply of low PV water to the North Pacific intermediate layer, particulalrly in spring. Our analysis shows that the dynamical adjustment to the western boundary mixing is conducted by both Kelvin and Rossby waves of 2nd and higher modes. The Kelvin waves propagate along the coast against the Kuroshio current, and split into two components: one propagating along the equator and the other passing through the Indonesian Archipelago. On the other hands, since the higher-mode Rossby waves are affected by the mean flow field, the waves move eastward. This feature differs from the classical thermohaline adjustment proccess of the deep layer (e.g., Kawase 1987), which takes into account the role of Kelvin waves alone in the eastward spreading. The propagation of both types of waves significantly modifies the circulation of the North Pacific intermediate layer

  12. Predisposition for borderline personality disorder with comorbid major depression is associated with that for polycystic ovary syndrome in female Japanese population

    Directory of Open Access Journals (Sweden)

    Kawamura S, Maesawa C, Nakamura K, Nakayama K, Morita M, Hiruma Y, Yoshida T, Sakai A, Masuda T

    2011-11-01

    Full Text Available Satoshi Kawamura1, Chihaya Maesawa2, Koji Nakamura1, Kazuhiko Nakayama1, Michiaki Morita1, Yohei Hiruma1, Tomoyuki Yoshida3, Akio Sakai3, Tomoyuki Masuda41Department of Psychiatry, Tokyo Jikei University school of Medicine, Tokyo, Japan; 2Department of Tumor Biology, Division of Bioscience, center for Advanced Medical science, Iwate Medical University school of Medicine, Morioka, Japan; 3Department of Neuropsychiatry, Iwate Medical University school of Medicine, Morioka, Japan; 4Department of Pathology, Iwate Medical University school of Medicine, Morioka, JapanAbstract: Polycystic ovary syndrome (PCOS is a common lifestyle-related endocrinopathy in women of reproductive age and is associated with several mental health problems. We examined the genotypic distributions of IRS-1 Gly972Arg and CYP11B2 -344T/C, which were previously described as influencing PCOS, and assayed the serum levels of interleukin-6 (IL-6 and tumor necrosis factor-alpha (TNF-α, in a set of female patients with borderline personality disorder (BPD with comorbid major depressive disorder (MDD (n = 50 and age-matched control subjects (n = 100, to investigate the predisposition for BPD with MDD. The results showed that the patients were more frequently IRS-1 972Arg variant allele carriers (P = 0.013; OR 6.68; 95% CI = 1.30-34.43 and homozygous for the CYP11B2 -344C variant allele (P = 0.022; OR = 3.32; 95% CI = 1.18-9.35 than the control subjects. The IL-6 level was significantly higher in the patients than in the controls (P < 0.0001. There was no significant difference in the serum TNF-α level between patients with BPD with MDD and the healthy comparison group (P = 0.5273. In conclusion, the predisposition for BPD with MDD is associated with that for PCOS, in the female Japanese population. An elevated serum IL-6 level is considered to be a possible biomarker of BPD with MDD.Keywords: borderline personality disorder, depression, polycystic ovary syndrome, genetic

  13. Local Schrodinger flow into Kahler manifolds

    Institute of Scientific and Technical Information of China (English)

    DlNG; Weiyue(

    2001-01-01

    [1]Ding, W. Y. , Wang, Y. D. , Schrodinger flows of maps into symplectic manifolds, Science in China, Ser. A, 1998, 41(7): 746.[2]Landau, L. D., Lifshitz, E. M., On the theory of the dispersion of magnetic permeability in ferromagnetic bodies, Phys. Z.Sowj., 1935, 8: 153; reproduced in Collected Papers of L. D. Landau, New York: Pergaman Press, 1965, 101-114.[3]Faddeev, L., Takhtajan, L. A. , Hamiltonian Methods in the Theory of Solitons, Berlin-Heidelberg-New York: Springer-Verlag, 1987.[4]Nakamura, K., Sasada, T., Soliton and wave trains in ferromagnets, Phys. Lett. A, 1974, 48: 321.[5]Zhou, Y. , Guo, B. , Tan, S. , Existence and uniqueness of smooth solution for system of ferromagnetic chain, Science in China, Ser. A, 1991, 34(3): 257.[6]Pang, P. , Wang, H. , Wang, Y. D. , Schrodinger flow of maps into Kahler manifolds, Asian J. of Math. , in press.[7]Wang, H. , Wang, Y. D. , Global inhomogeneous Schrodinger flow, Int. J. Math., 2000, 11: 1079.[8]Pang, P., Wang, H., Wang, Y. D., Local existence for inhomogeneous Schrodinger flow of maps into Kahler manifolds,Acta Math. Sinica, English Series, 2000, 16: 487.[9]Temg, C. L., Uhlenbeck, K., Schrodinger flows on Grassmannians, in Integrable Systems, Geometry and Topology,Somervi11e, MA: International Press, in press.[10]Chang, N., Shatah, J., Uhlenbeck, K., Schrodinger maps, Commun. Pure Appl. Math., 2000, 53: 157.[11]Wang, Y. D., Ferromagnetic chain equation from a closed Riemannian manifold into S2, Int. J. Math., 1995, 6: 93.[12]Wang, Y. D., Heisenberg chain systems from compact manifolds into S2, J. Math. Phys., 1998, 39(1): 363.[13]Sulem, P., Sulem, C., Bardos, C., On the continuous limit for a system of classical spins, Commun. Math. Phys., 1986,107: 431.[14]Aubin, T., Nonlinear Analysis on Manifolds, Monge-Ampère Equations, Berlin-Heidelberg-New York: Springer-Verlag,1982.[15]Eells, J. , Lemaire, L. , Another report on harmonic maps, Bull. London

  14. Book Reviews

    Directory of Open Access Journals (Sweden)

    Gert J. Oostindie

    1987-04-01

    Full Text Available - M.M. van Bruinessen, Ann Kumar, The diary of a Javanese Muslim; Politics and the pesantren 1883-1886, Canberra: Australian National University, Faculty of Asian Studies Monographs, New Series No. 71, 1985. - J.G. de Casparis, John N. Miksic, Archaeological research on the ‘Forbidden Hill’ of Singapore: Excavations at Fort Canning, 1984, Singapore: National Museum, 1985. - Bernhard Dahm, Audrey R. Kahin, Regional dynamics of the Indonesian revolution; Unity from diversity, Honolulu: University of Hawaii Press, 1985. XI + 306 pp. - G.W.J. Drewes, Marcel Bonneff, Pérégrinations javanaises. Les Voyages de R.M.A. Purwalelana; Une vision de Java au XIXe siècle (c.1860-1875, Études insulindiennes/Archipel, 7, Éditions de la Maison des Sciences de l’Homme, Paris, 1986. 384 pp. - C. Fasseur, C.W. Watson, Kerinci. Two historical studies. Occasional paper no.3, University of Kent at Canterbury, 1984, X + 63 pp. - L.G.M. Jaquet, The Kenpeitai in Java and Sumatra; Selections form the authorised history of the Kenpietai by the national federation of Kenpeitai veterans associations. - Pieter ter Keurs, Erhard Schlesier, Me’udana, Südost-Neuguinea, Teil 2, Das soziale Leben, 1983. - Werner Kraus, Mitsuo Nakamura, The crescent arises over the Banyan tree, Yogyakarta: Gadjah Mada University Press, 1983. XI + 223 pp. - J.A. de Moor, Leon Salim, Prisoners of Kota Cane, (Translated and introduced by Audrey R. Kahin, Ithaca, New York: Cornell modern Indonesia project, translation series, no. 66, 1986, 112 pp. - Gert J. Oostindie, Cornelis Ch. Goslinga, The Dutch in the Caribbean and in the Guianas 1680-1791. Assen: Van Gorcum, 1985. xvi + 712 pp., ill. - Gert J. Oostindie, Cornelis Ch. Goslinga, The Dutch in the Caribbean and on the Wild coast 1580-1680. Assen: Van Gorcum, 1971. xvi + 647 pp., ills. - S.O. Robson, J. Joseph Errington, Language and social change in Java: Linguistic reflexes of modernization in a traditional royal polity, Athens, Ohio

  15. Characterization of H/V Spectral Ratios for the Assessment of Slope Stability in the Gas Hydrate-rich Area: an Example from Offshore SW Taiwan

    Science.gov (United States)

    Lin, J. Y.; Tsia, C. H.; Cheng, W. B.; Chin, S. J.; Lin, S. S.; Liang, C. W.

    2015-12-01

    The Nakamura's method, which calculates the ratios between horizontal and vertical component spectra of seismic signals (H/V), is widely used in the inland area. However, few related estimations were performed for the offshore area and little knowledge for the marine sediments were obtained. From 2013 to 2015, three passive ocean bottom seismometer (OBS) experiments were conducted in gas hydrate-rich area offshore SW Taiwan in the aim of acquiring information related to the physical properties of seafloor sediments. The H/V of the seafloor sediments in the three areas were estimated by using the ambient noise and seismic signal recorded by OBSs. The resonance frequency of each site was estimated from the main peak of H/V distribution and a range between 5 and 10 Hz were obtained. Based on the empirical law, this resonance frequency range should correspond to a sediment thickness of approximately several to ten of meters. This estimation is consistent with the thickness of the sedimentary cover imaged by chirp sonar survey, suggesting that the site response of seafloor is dominantly controlled by the unconsolidated sedimentary layer on the top of the sea bed. Remarkably, the H/V ratios obtained in our study area are much larger than that calculated for the inland areas. The magnification can reach as high as 50 to more than 100. This observation infers that the sea water movement might emphasize the horizontal motion of the marine sediments, which is crucial for the slope stability assessment. Moreover, for most stations located in the active margin, no distinct peak is observed for the H/V pattern calculated during earthquakes. However, in the passive margin, the H/V peak calculated from ambient noise and earthquakes is mostly identical. This phenomenon may suggest that relatively unclear sedimentary boundary exist in the active margin environment. Estimating H/V spectral ratios of data recorded by the OBSs deployed in the southwest Taiwan offshore area offers a

  16. Initial hydrodynamic study on a new intraaortic axial flow pump: Dynamic aortic valve

    Institute of Scientific and Technical Information of China (English)

    LI; Guorong

    2001-01-01

    pump: the valvo-pump, in Heart Replacement: Artificial Heart (eds. Akutsu, T., Koyanagi, H.), 4, Tokyo: Springer-Verlag, 1993, 267-272.[13] Mitamura,Y., Nakamura,H., Okamoto,E.et al., Development of the valvo-pump:an axial flow pump implanted at the heart valve position,Artif.Organs,1999,23:566/

  17. Theoretical study of ultraviolet induced photodissociation dynamics of sulfuric acid

    Energy Technology Data Exchange (ETDEWEB)

    Murakami, Tatsuhiro; Ohta, Ayumi; Suzuki, Tomoya; Ikeda, Kumiko [Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-Cho, Chiyoda-ku, Tokyo 102-8554 (Japan); Danielache, Sebastian O. [Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-Cho, Chiyoda-ku, Tokyo 102-8554 (Japan); Earth-Life Science Institute (ELSI), Tokyo Institute of Technology (Japan); Department of Environmental Science and Techonology, Interdisciplinary Graduate School of Science and Engineering, Tokyo Institute of Technology, Yoohama 226-8502 (Japan); Nanbu, Shinkoh, E-mail: shinkoh.nanbu@sophia.ac.jp [Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioi-Cho, Chiyoda-ku, Tokyo 102-8554 (Japan)

    2015-05-01

    Highlights: • Photodissociation dynamics of H{sub 2}SO{sub 4} at low-lying electronically excited states were investigated. • Photochemical processes were simulated by on-the-fly ab initio MD. • Sulfuric acid after the excitation to the S{sub 1} state dissociated to HSO{sub 4}(1{sup 2}A″) + H({sup 2}S). • Sulfuric acid after the excitation to the S{sub 2} state dissociated to HSO{sub 4}(2{sup 2}A″) + H({sup 2}S). • The energy region of the UV spectra where NMD fractionation may occur is predicted. - Abstract: Photodissociation dynamics of sulfuric acid after excitation to the first and second excited states (S{sub 1} and S{sub 2}) were studied by an on-the-fly ab initio molecular dynamics simulations based on the Zhu–Nakamura version of the trajectory surface hopping (ZN-TSH). Forces acting on the nuclear motion were computed on-the-fly by CASSCF method with Dunning’s augmented cc-pVDZ basis set. It was newly found that the parent molecule dissociated into two reaction-channels (i) HSO{sub 4}(1{sup 2}A″) + H({sup 2}S) by S{sub 1}-excitation, and (ii) HSO{sub 4}(2{sup 2}A″) + H({sup 2}S) by S{sub 2}-excitation. The direct dissociation dynamics yield products different from the SO{sub 2} + 2OH fragments often presented in the literature. Both channels result in the same product and differs only in the electronic state of the HSO{sub 4} fragment{sub .} The trajectories running on S{sub 2} do not hop with S{sub 0} and a nonadiabatic transition happens at the S{sub 2}–S{sub 1} conical intersection located at a longer OH bond-length than the S{sub 1}–S{sub 0} intersection producing an electronic excited state (2{sup 2}A″) of HSO{sub 4} product.

  18. Short-term bisphosphonate treatment reduces serum 25(OH vitamin D3 and alters values of parathyroid hormone, pentosidine, and bone metabolic markers

    Directory of Open Access Journals (Sweden)

    Kamimura M

    2017-02-01

    Full Text Available Mikio Kamimura,1 Shigeharu Uchiyama,2 Yukio Nakamura,2,3 Shota Ikegami,2 Keijiro Mukaiyama,2 Hiroyuki Kato2 1Center for Osteoporosis and Spinal Disorders, Kamimura Orthopaedic Clinic, Matsumoto, Japan; 2Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Japan; 3Department of Orthopedic Surgery, Showa-Inan General Hospital, Komagane, Japan Abstract: This study aimed to clarify the effects of short-term bisphosphonate (BP administration in Japanese osteoporotic patients retrospectively. Daily minodronate (MIN at 1 mg/day (MIN group or weekly risedronate (RIS at 17.5 mg/week (RIS group was primarily prescribed for each patient. We analyzed the laboratory data of 35 cases (18 of MIN and 17 of RIS before the start of treatment and at 4 months afterward. The changes in 25(OHD3, whole parathyroid hormone (PTH, serum pentosidine, and the bone turnover markers urinary cross-linked N-telopeptide of type I collagen (NTX, serum tartrate-resistant acid phosphatase (TRACP-5b, bone-specific alkaline phosphatase (BAP, and undercarboxylated osteocalcin were evaluated. Overall, serum 25(OHD3 was significantly decreased from 21.8 to 18.4 ng/mL at 4 months, with a percent change of –14.7%. Whole PTH increased significantly from 23.4 to 30.0 pg/mL, with a percent change of 32.1%. Serum pentosidine rose from 0.0306 to 0.0337 µg/mL, with a percent change of 15.2%. In group comparisons, 25(OHD3 and pentosidine showed comparable changes in both groups after 4 months of treatment, whereas whole PTH became significantly more increased in the MIN group. All bone turnover markers were significantly decreased at 4 months in both groups. Compared with the RIS group, the MIN group exhibited significantly larger value changes for urinary NTX, serum TRACP-5b, and BAP at the study end point. This study demonstrated that serum 25(OHD3 became significantly decreased after only 4 months of BP treatment in Japanese osteoporotic patients and

  19. Mapping sediment thickness of Islamabad city using empirical relationships: Implications for seismic hazard assessment

    Indian Academy of Sciences (India)

    Sarfraz Khan; M Asif Khan

    2016-04-01

    Soft sediments make an important component of the subsurface lithology, especially in areas underlain by river/stream basins. Occupying a position directly above the bedrock up to the land surface, these soft sediments can range in thickness from few centimeters to hundreds of meters. They carry a specialnuisance in seismic hazards, as they serve as a source of seismic amplification that may enhance the seismic shaking of many folds. Determination of the thickness of the soft sediments is therefore crucial in seismic hazard analysis. A number of studies in recent years have demonstrated that frequency andamplitude spectrum obtained from the noise measurements during the recording of natural seismicitycan be used to obtain thickness of soft sediments covering the bedrock. Nakamura (1989) presented atechnique to determine such spectrum using ratio of horizontal to vertical components of the Rayleighwaves. The present study is based on an extensive set of microtremor measurements carried out in theIslamabad city, Pakistan. Fundamental frequencies were obtained from weak motion sensors and TrominoEngy Plus instruments to show that the correlation is clearly valid for a wide range of sediment thickness.A simple formula was derived for the investigated area to determine directly the thickness of sedimentsfrom the main peaks in the H/V spectrum for seismometer and Tromino data separately. A comparisonis made between sediment thicknesses derived from empirical relations developed in this study withthose given in literature to demonstrate a positive correlation. The correlation of instrumental resonantfrequencies with calculated resonant frequencies (theoretical) suggests that the relation derived from thenoise measurements mostly depends on the velocity depth function of the shear wave. The fundamentalfrequency of the main peak of spectral ratio of H/V using the both instruments correlates well withthe thickness of sediments at the site obtained from the borehole data. It

  20. First-principles study of cesium adsorption to weathered micaceous clay minerals

    Science.gov (United States)

    Okumura, Masahiko; Nakamura, Hiroki; Machida, Masahiko

    2014-05-01

    , H. Nakamura, and M. Machida, Mechanism of Strong Affinity of Clay Minerals to Radioactive Cesium : First-Principles Calculation Study for Adsorption of Cesium at Frayed Edge Sites in Muscovite, Journal of the Physical Society of Japan 82, 033802 (2013).

  1. Effects of indacaterol versus tiotropium on respiratory mechanics assessed by the forced oscillation technique in patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Inui N

    2015-06-01

    Full Text Available Naoki Inui,1,2 Sayomi Matsushima,1 Shinpei Kato,1 Hideki Yasui,1 Masato Kohno,1 Tomoyuki Fujisawa,1 Noriyuki Enomoto,1 Yutaro Nakamura,1 Mikio Toyoshima,3 Takafumi Suda1 1Second Division, Department of Internal Medicine, 2Department of Clinical Pharmacology and Therapeutics, Hamamatsu University School of Medicine, Handayama, Hamamatsu, Japan; 3Department of Respiratory Medicine, Hamamatsu Rosai Hospital, Shougen-cho, Hamamatsu, JapanAbstract: The forced oscillation technique (FOT can measure respiratory mechanics and has attracted attention in chronic obstructive pulmonary disease (COPD. We aimed to evaluate the effects of only indacaterol and tiotropium monotherapies on airflow limitation and respiratory impedance. Pulmonary function tests, COPD assessment test (CAT, and multifrequency FOT with MostGraph-01 were performed at the beginning and after 8 weeks of treatment with indacaterol or tiotropium. The resistance index, resistance at 5 Hz (R5, resistance at 20 Hz (R20, reactance index, reactance at 5 Hz (X5, resonant frequency (Fres, and low-frequency reactance area (ALX were determined at whole-breath, inspiratory, and expiratory phases. Eighty-two patients (mean age: 73 years; mean forced expiratory volume in 1 second (FEV1: 61.6%±19.0% predicted were randomized to indacaterol or tiotropium treatment. Both bronchodilators improved airflow limitation, with mean trough improvements in FEV1 of 165 mL and 80 mL in the indacaterol and tiotropium groups, respectively. The CAT score decreased in the indacaterol group (P<0.001; 11.2±6.6 to 7.5±5.6. Compared with tiotropium, indacaterol significantly improved FEV1, percent predicted FEV1, and CAT score (P=0.042, P=0.008, and P=0.027, respectively. For respiratory impedance, indacaterol and tiotropium changed R5, X5, Fres, and ALX at whole-breath, inspiratory, and expiratory phases. In the indacaterol group, the changes in R5, R5–R20, X5, Fres, and ALX were significantly correlated

  2. Velocity and structural model of the Lower Tagus Basin according to the study of environmental seismic noise

    Science.gov (United States)

    Gomes Torres, Ricardo Jorge; Furtado, José Augusto; Gonçalves Silva, Hugo; Borges, José Fernando; Caldeira, Bento; Bezzeghoud, Mourad; Carvalho, João

    2013-04-01

    ] Torres, R.J.G., (2012). Modelo de velocidade da Bacia do Vale do Tejo: uma abordagem baseada no estudo do ruído sísmico ambiental, Master Thesis, Universidade de Évora, 83pp. [3] Nakamura, Y., 1989. A method for dynamic characteristics estimations of subsurface using microtremors on the ground surface, Quarterly Report, RTRI, Japan, v. 30, p. 25-33. [4] J.A. Furtado, Confirmação do modelo da estrutura 3D do Vale Inverior do Tejo a partir de dados de ruído sísmico ambiente, Master Thesis, Universidade de Évora, 136pp, 2010.

  3. Two-Oxide Disequilibrium: A New Geospeedometer Based on Diffusion in Ilmenite

    Science.gov (United States)

    Williams, K. B.; Krawczynski, M. J.; Van Orman, J. A.

    2016-12-01

    -61.[3] Nakamura (1995) Geology 23, 807-810.[4] Venezky & Rutherford (1999) J. Volc. Geo. Res. 89, 213-230.

  4. False Negative Rates of a Macrofoam-Swab Sampling Method with Low Surface Concentrations of Two Bacillus anthracis Surrogates via Real-Time PCR

    Energy Technology Data Exchange (ETDEWEB)

    Hutchison, Janine R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Piepel, Gregory F. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Amidan, Brett G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Sydor, Michael A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Deatherage Kaiser, Brooke L [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2015-05-01

    Surface sampling for Bacillus anthracis spores has traditionally relied on detection via bacterial cultivation methods. Although effective, this approach does not provide the level of organism specificity that can be gained through molecular techniques. False negative rates (FNR) and limits of detection (LOD) were determined for two B. anthracis surrogates with modified rapid viability-polymerase chain reaction (mRV-PCR) following macrofoam-swab sampling. This study was conducted in parallel with a previously reported study that analyzed spores using a plate-culture method. B. anthracis Sterne (BAS) or B. atrophaeus Nakamura (BG) spores were deposited onto four surface materials (glass, stainless steel, vinyl tile, and plastic) at nine target concentrations (2 to 500 spores/coupon; 0.078 to 19.375 colony-forming units [CFU] per cm²). Mean FNR values for mRV-PCR analysis ranged from 0 to 0.917 for BAS and 0 to 0.875 for BG and increased as spore concentration decreased (over the concentrations investigated) for each surface material. FNRs based on mRV-PCR data were not statistically different for BAS and BG, but were significantly lower for glass than for vinyl tile. FNRs also tended to be lower for the mRV-PCR method compared to the culture method. The mRV-PCR LOD₉₅ was lowest for glass (0.429 CFU/cm² with BAS and 0.341 CFU/cm² with BG) and highest for vinyl tile (0.919 CFU/cm² with BAS and 0.917 CFU/cm² with BG). These mRV-PCR LOD₉₅ values were lower than the culture values (BAS: 0.678 to 1.023 CFU/cm² and BG: 0.820 to 1.489 CFU/cm²). The FNR and LOD₉₅ values reported in this work provide guidance for environmental sampling of Bacillus spores at low concentrations.

  5. Association of social support with gratitude and sense of coherence in Japanese young women: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Fujitani T

    2017-06-01

    Full Text Available Tomoko Fujitani,1 Kumiko Ohara,1 Katsuyasu Kouda,2 Tomoki Mase,3 Chiemi Miyawaki,4,5 Katsumasa Momoi,1,6 Yoshimitsu Okita,7 Maki Furutani,1 Harunobu Nakamura1 1Graduate School of Human Development and Environment, Kobe University, Kobe, 2Department of Public Health, Faculty of Medicine, Kindai University, Osaka-Sayama, 3Faculty of Human Development and Education, Kyoto Women’s University, 4Department of Early Childhood Education, Heian Jogakuin College, Kyoto, 5Kagoshima University Research Field in Education, Education, Law, Economics and the Humanities Area, Kagoshima, 6Faculty of Health and Welfare, Tokushima Bunri University, Tokushima, 7Graduate School of Integrated Science and Technology, College of Engineering, Academic Institute, Shizuoka University, Hamamatsu, Shizuoka, Japan Purpose: Recent studies have shown that perceived social support is associated with gratitude and sense of coherence, but evidence for this concept remains scarce. In the present study, we investigated relationships between social support, gratitude, and sense of coherence, focusing on the construct of and source of social support among young women. Methods: The study was conducted in 2014 in Japan. Participants comprised 208 female university students (aged 19.9 ± 1.1 years, who completed a self-administered anonymous questionnaire regarding perceived social support, gratitude, and sense of coherence. Results: Emotional and instrumental social support from acquaintances were found to be lower than those from family and friends. Gratitude was positively correlated with all forms of social support except instrumental social support from acquaintances. However, sense of coherence was positively correlated with both emotional and instrumental social support from family and only emotional social support from acquaintances. Multiple regression analysis showed that ­emotional support from family and emotional support from acquaintances were positively associated

  6. Additive effects of cilnidipine, an L-/N-type calcium channel blocker, and an angiotensin II receptor blocker on reducing cardiorenal damage in Otsuka Long-Evans Tokushima Fatty rats with type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Mori Y

    2014-06-01

    Full Text Available Yutaka Mori,1,2 Shizuka Aritomi,3 Kazumi Niinuma,3 Tarou Nakamura,3 Kenichi Matsuura,1 Junichi Yokoyama,1 Kazunori Utsunomiya1 1Division of Diabetes and Endocrinology, Department of Internal Medicine, The Jikei University School of Medicine, Minato-ku, Japan; 2Department of Clinical Research, National Hospital Organization, Utsunomiya National Hospital, Utsunomiya, Japan; 3Research Center, Ajinomoto Pharmaceuticals Co, Ltd, Kanagawa, Japan Abstract: Cilnidipine (Cil, which is an L-/N-type calcium channel blocker (CCB, has been known to provide renal protection by decreasing the activity of the sympathetic nervous system (SNS and the renin–angiotensin system. In this study, we compared the effects of the combination of Cil and amlodipine (Aml, which is an L-type CCB, with an angiotensin (Ang II receptor blocker on diabetic cardiorenal damage in spontaneously type 2 diabetic rats. Seventeen-week-old Otsuka Long-Evans Tokushima Fatty rats were randomly assigned to receive Cil, Aml, valsartan (Val, Cil + Val, Aml + Val, or a vehicle (eight rats per group for 22 weeks. Antihypertensive potencies were nearly equal among the CCB monotherapy groups and the combination therapy groups. The lowering of blood pressure by either treatment did not significantly affect the glycemic variables. However, exacerbations of renal and heart failure were significantly suppressed in rats administered Cil or Val, and additional suppression was observed in those administered Cil + Val. Although Val increased the renin–Ang system, Aml + Val treatment resulted in additional increases in these parameters, while Cil + Val did not show such effects. Furthermore, Cil increased the ratio of Ang-(1–7 to Ang-I, despite the fact that Val and Aml + Val decreased the Ang-(1–7 levels. These actions of Cil + Val might be due to their synergistic inhibitory effect on the activity of the SNS, and on aldosterone secretion through N-type calcium channel antagonism and Ang II

  7. Ocular hypotensive effects of a Rho-associated protein kinase inhibitor in rabbits

    Directory of Open Access Journals (Sweden)

    Kamaruddin MI

    2017-03-01

    Full Text Available Muhammad Irfan Kamaruddin,1,2 Momoko Nakamura-Shibasaki,1 Yu Mizuno,1 Yoshiaki Kiuchi1 1Department of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 2Department of Ophthalmology, Hasanuddin University, Makassar, South Sulawesi, Indonesia Purpose: Ripasudil is a novel Rho-associated protein kinase inhibitor that is used to treat ocular hypertension. However, the comparison of the intraocular pressure (IOP-lowering effects between ripasudil alone and other ocular hypotensive drugs has not been studied thoroughly. The purpose of this study is to examine the ocular hypotensive effects of 0.4% ripasudil, 2% pilocarpine, 0.5% timolol and 0.1% dorzolamide in rabbits. We also studied the IOP changes when 0.4% ripasudil was combined with 2% pilocarpine, 0.5% timolol or 0.1% dorzolamide. Methods: One drop of saline solution, 0.4% ripasudil, 0.5% timolol, 2% pilocarpine or 1% dorzolamide or a combination of these agents was applied topically to the left eyes of eight healthy albino rabbits. Posttreatment changes in the IOP of albino rabbits were monitored using a rebound tonometer over a 5-h time course. Changes in IOP after application of saline served as the control. One-way analysis of variance and Dunnett’s post hoc tests were used for statistical analyses. Results: After topical instillation, 0.4% ripasudil resulted in significant decreases in IOP at 0.5 and 1 h compared with the control group. Treatment with timolol, pilocarpine or dorzolamide had no significant effect on IOP. Treatment with timolol, pilocarpine or dorzolamide in combination with ripasudil resulted in significant reductions in IOP at 1 h. However, none of these agents enhanced the IOP-lowering effects of ripasudil. Conclusion: Ripasudil has stronger IOP-lowering effects than timolol, pilocarpine or dorzolamide hypotensive agents in our rabbit model. Addition of timolol, pilocarpine or dorzolamide did not enhance

  8. Dermopathy associated with cetuximab and panitumumab: investigation of the usefulness of moisturizers in its management

    Directory of Open Access Journals (Sweden)

    Watanabe S

    2017-09-01

    Full Text Available Shoichi Watanabe,1 Motoki Nakamura,1 Hiroki Takahashi,2 Masayasu Hara,2 Kei Ijichi,3 Daisuke Kawakita,3 Akimichi Morita1 1Department of Geriatric and Environmental Dermatology, 2Department of Gastroenterological Surgery, 3Department of Neuro-otolaryngology, Nagoya City University Graduate School of Medical Science, Nagoya, Japan Aims: Limited data regarding the objective evaluation of skin exsiccation caused by epidermal growth factor receptor (EGFR inhibitors exist. Objective indices were applied to evaluate the usefulness of a moisturizer against skin exsiccation associated with the use of EGFR inhibitors in cancer patients. Patients and methods: Patients with either colorectal or head and neck cancer treated with either cetuximab or panitumumab were randomly assigned 1:2 to the prophylactic-treatment arm, where participants received prophylactical moisturizer treatment (heparinoid preparation, Hirudoid®, or to the symptomatic-treatment arm, where moisturizer was applied after the onset of cutaneous symptoms. Patients were observed for 6 weeks after the start of the administration of EGFR inhibitor. Results: A total of 15 patients were included and assessed: 6 in the prophylactic treatment group and 9 in the symptomatic treatment group. We evaluated the effect of EGFR inhibitors on the physiologic function of the skin. Administration of EGFR inhibitors resulted in a continued reduction in the moisture content of the horny layer and a decrease in cutaneous sebum levels. Skin observation revealed frequent development of an acneiform rash and significantly higher exsiccation and exfoliation scores. Administration of EGFR inhibitor was associated with a decrease in the horny layer moisture content and lower cutaneous sebum levels in the symptomatic treatment group. In contrast, levels of both the indicators were increased in the prophylactic treatment group. Moreover, the EGFR inhibitor-associated increase in exsiccation and exfoliation scores

  9. Simple and accurate scheme to compute electrostatic interaction: Zero-dipole summation technique for molecular system and application to bulk water

    Science.gov (United States)

    Fukuda, Ikuo; Kamiya, Narutoshi; Yonezawa, Yasushige; Nakamura, Haruki

    2012-08-01

    The zero-dipole summation method was extended to general molecular systems, and then applied to molecular dynamics simulations of an isotropic water system. In our previous paper [I. Fukuda, Y. Yonezawa, and H. Nakamura, J. Chem. Phys. 134, 164107 (2011), 10.1063/1.3582791], for evaluating the electrostatic energy of a classical particle system, we proposed the zero-dipole summation method, which conceptually prevents the nonzero-charge and nonzero-dipole states artificially generated by a simple cutoff truncation. Here, we consider the application of this scheme to molecular systems, as well as some fundamental aspects of general cutoff truncation protocols. Introducing an idea to harmonize the bonding interactions and the electrostatic interactions in the scheme, we develop a specific algorithm. As in the previous study, the resulting energy formula is represented by a simple pairwise function sum, enabling facile applications to high-performance computation. The accuracy of the electrostatic energies calculated by the zero-dipole summation method with the atom-based cutoff was numerically investigated, by comparison with those generated by the Ewald method. We obtained an electrostatic energy error of less than 0.01% at a cutoff length longer than 13 Å for a TIP3P isotropic water system, and the errors were quite small, as compared to those obtained by conventional truncation methods. The static property and the stability in an MD simulation were also satisfactory. In addition, the dielectric constants and the distance-dependent Kirkwood factors were measured, and their coincidences with those calculated by the particle mesh Ewald method were confirmed, although such coincidences are not easily attained by truncation methods. We found that the zero damping-factor gave the best results in a practical cutoff distance region. In fact, in contrast to the zero-charge scheme, the damping effect was insensitive in the zero-charge and zero-dipole scheme, in the

  10. Impact of β-blocker selectivity on long-term outcomes in congestive heart failure patients with chronic obstructive pulmonary disease

    Directory of Open Access Journals (Sweden)

    Kubota Y

    2015-03-01

    Full Text Available Yoshiaki Kubota, Kuniya Asai, Erito Furuse, Shunichi Nakamura, Koji Murai, Yayoi Tetsuou Tsukada, Wataru Shimizu Department of Medicine (Division of Cardiology, Nippon Medical School, Bunkyo-ku, Tokyo, Japan Background: Chronic obstructive pulmonary disease (COPD is present in approximately one-third of all congestive heart failure (CHF patients, and is a key cause of underprescription and underdosing of β-blockers, largely owing to concerns about precipitating respiratory deterioration. For these reasons, the aim of this study was to evaluate the impact of β-blockers on the long-term outcomes in CHF patients with COPD. In addition, we compared the effects of two different β-blockers, carvedilol and bisoprolol. Methods: The study was a retrospective, non-randomized, single center trial. Acute decompensated HF patients with COPD were classified according to the oral drug used at discharge into β-blocker (n=86; carvedilol [n=52] or bisoprolol [n=34] and non-β-blocker groups (n=46. The primary endpoint was all-cause mortality between the β-blocker and non-β-blocker groups during a mean clinical follow-up of 33.9 months. The secondary endpoints were the differences in all-cause mortality and the hospitalization rates for CHF and/or COPD exacerbation between patients receiving carvedilol and bisoprolol. Results: The mortality rate was higher in patients without β-blockers compared with those taking β-blockers (log-rank P=0.039, and univariate analyses revealed that the use of β-blockers was the only factor significantly correlated with the mortality rate (hazard ratio: 0.41; 95% confidence interval: 0.17–0.99; P=0.047. Moreover, the rate of CHF and/or COPD exacerbation was higher in patients treated with carvedilol compared with bisoprolol (log-rank P=0.033. In the multivariate analysis, only a past history of COPD exacerbation significantly increased the risk of re-hospitalization due to CHF and/or COPD exacerbation (adjusted hazard

  11. The reasons for triple therapy in stable COPD patients in Japanese clinical practice

    Directory of Open Access Journals (Sweden)

    Miyazaki M

    2015-06-01

    Full Text Available Masaki Miyazaki,1 Hidetoshi Nakamura,1,2 Saeko Takahashi,1 Shotaro Chubachi,1 Mamoru Sasaki,1 Mizuha Haraguchi,1 Hideki Terai,1 Makoto Ishii,1 Koichi Fukunaga,1 Sadatomo Tasaka,1 Kenzo Soejima,1 Koichiro Asano,3 Tomoko Betsuyaku1 On behalf of the Keio COPD Comorbidity Research (K-CCR group 1Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, 2Department of Respiratory Medicine, Saitama Medical University, Saitama, 3Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Kanagawa, Japan Background: Triple combination therapy involving long-acting muscarinic antagonists long-acting β2 agonists, and inhaled corticosteroids has recently become an option for maintenance treatment of COPD. Some add-on clinical trials have reported the benefits of these combinations. However, the process to step up to triple therapy varies for individual cases.Methods: Keio University and affiliated hospitals conducted an observational COPD cohort study, recruiting patients diagnosed as having COPD by pulmonary physicians and those referred for investigation of possible COPD. Their prescription history and clinical course were retrospectively analyzed based on the physicians’ medical records and patient questionnaires. This study was registered with UMIN (UMIN000003470, April 10, 2010.Results: A total of 95 of the 445 COPD patients (21% were treated with inhaled corticosteroids/long-acting β2 agonists/long-acting muscarinic antagonists as maintenance therapy, including 12 in COPD Grade I, 31 in Grade II, 38 in Grade III, and 14 in Grade IV, based on the Global Initiative for Chronic Obstructive Lung Disease spirometric grading. For more than half of the patients on triple therapy, the treatment had been intensified due to unsatisfactory improvement of symptoms, and 32% were treated with triple therapy due to comorbid asthma. In contrast, there were COPD patients whose therapy was

  12. Catechol-O-methyltransferase Val158Met genotype and the clinical responses to duloxetine treatment or plasma levels of 3-methoxy-4-hydroxyphenylglycol and homovanillic acid in Japanese patients with major depressive disorder

    Directory of Open Access Journals (Sweden)

    Atake K

    2015-04-01

    Full Text Available Kiyokazu Atake, Reiji Yoshimura, Hikaru Hori, Asuka Katsuki, Jun Nakamura Department of Psychiatry, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan Purpose: This study investigated the relationships among the plasma levels of catecholamine metabolites, the clinical response to duloxetine treatment, and Val158Met polymorphism of the catechol-O-methyltransferase (COMT gene. Subjects and methods: Sixty-four patients and 30 healthy control subjects were recruited. Major depressive episodes were diagnosed using the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision criteria. The severity of depression was evaluated using the 17-item Hamilton Rating Scale for Depression (HAMD17. Patients whose HAMD17 scores were 15 or greater were enrolled in the study. Blood sampling and clinical evaluation were performed at week 0 and week 8. The levels of plasma catecholamine metabolites were measured using high-performance liquid chromatography with electrochemical detection. Genotyping was performed using direct sequencing. Results: Thirty of 45 patients (67% responded to duloxetine treatment during the 8 weeks of treatment. The baseline plasma levels of 3-methoxy-4-hydroxyphenylglycol (MHPG, but not homovanillic acid (HVA, were lower in patients with major depressive disorder (MDD who had the Val/Val genotype than in patients who were Met-carriers. Patients with MDD and the Val/Val genotype, but not Met carriers, had increased plasma levels of MHPG after 8 weeks of duloxetine treatment. The baseline plasma MHPG levels in healthy control subjects with the Val/Val genotype were significantly higher than those in patients with MDD. Among the subjects in the MDD group with the Val/Val genotype, the plasma MHPG levels increased to the same degree as in the healthy control subjects with the Val/Val genotype after 8 weeks of duloxetine treatment. Conclusion: The

  13. High Prevalence of chronic kidney disease among patients with sleep related breathing disorder (SRBD).

    Science.gov (United States)

    Iseki, Kunitoshi; Tohyama, Kazuyo; Matsumoto, Tsuyoshi; Nakamura, Hiroshi

    2008-02-01

    Sleep apnea syndrome, a sleep-related breathing disorder (SRBD) of which obstructive sleep apnea syndrome (OSAS) is representative, is often associated with obesity, and therefore patients with SRBD might have a high prevalence of chronic kidney disease (CKD). However, the relationship between obesity and the prevalence of CKD has not yet been investigated in a large cohort of patients with SRBD. The Okinawa Nakamura Clinic Sleep Apnea Syndrome (ONSLEEP) registry contains records for all patients evaluated by full-scale polysomnography (PSG) from September 1990 to the end of 2003 (n=5,651). We studied the total of 4,056 (71.8%) of these patients who had an apnea hypopnea index (AHI) of more than 5 events per hour. The glomerular filtration rate (GFR) was estimated using the abbreviated Modification of Diet in Renal Disease equation in the 1,624 patients for whom serum creatinine data was obtained at the time of the PSG. We defined CKD as a GFR of less than 60 mL/min/1.73 m2. The mean age was 49.9+/-13.5 (mean+/-SD) years; the mean body mass index (BMI) was 28.4+/-5.0 (mean+/-SD) kg/m2. We compared the findings with those from participants in the 1993 general screening registry in Okinawa (n=94,267). From among the total 94,267 screening participants, we selected 7,454 subjects who were age- and sex-matched to the experimental group with SRBD; the ratio of cases to controls was thus approximately 1:4. CKD was detected in 496 (30.5%) patients, with SRBD a higher incidence than that in the screened population (9.1%); the adjusted odds ratio (95% confidence interval) was 4.542 (3.922-5.260, p or =30.0 kg/m2); in the controls the values were 8.1%, 10.5%, and 10.6%, respectively. Taken together, these results suggest that surveillance of CKD is warranted among SRBD patients, particularly those who are not obese.

  14. Gravitational waves from a compact star in a circular, inspiral orbit, in the equatorial plane of a massive, spinning black hole, as observed by LISA

    Energy Technology Data Exchange (ETDEWEB)

    Finn, Lee Samuel; Thorne, Kip S.

    2000-12-15

    Results are presented from high-precision computations of the orbital evolution and emitted gravitational waves for a stellar-mass object spiraling into a massive black hole in a slowly shrinking, circular, equatorial orbit. The focus of these computations is inspiral near the innermost stable circular orbit (isco) -- more particularly, on orbits for which the angular velocity {Omega} is 0.03{approx}<{Omega}/{Omega}{sub isco}{<=}1.0. The computations are based on the Teuksolsky-Sasaki-Nakamura formalism, and the results are tabulated in a set of functions that are of order unity and represent relativistic corrections to low-orbital-velocity formulas. These tables can form a foundation for future design studies for the LISA space-based gravitational-wave mission. A first survey of applications to LISA is presented: Signal to noise ratios S/N are computed and graphed as functions of the time-evolving gravitational-wave frequency for the lowest three harmonics of the orbital period, and for various representative values of the hole's mass M and spin a and the inspiraling object's mass {mu}, with the distance to Earth chosen to be r{sub o}=1 Gpc. These S/N's show a very strong dependence on the black-hole spin, as well as on M and {mu}. Graphs are presented showing the range of the {l_brace}M,a,{mu}{r_brace} parameter space, for which S/N>10 at r{sub 0}=1 Gpc during the last year of inspiral. The hole's spin a has a factor of {approx}10 influence on the range of M (at fixed {mu}) for which S/N>10, and the presence or absence of a white-dwarf--binary background has a factor of {approx}3 influence. A comparison with predicted event rates shows strong promise for detecting these waves, but not beyond about 1 Gpc if the inspiraling object is a white dwarf or neutron star. This argues for a modest lowering of LISA's noise floor. A brief discussion is given of the prospects for extracting information from the observed waves.

  15. Application of the H/V and SPAC Method to Estimate a 3D Shear Wave Velocity Model, in the City of Coatzacoalcos, Veracruz.

    Science.gov (United States)

    Morales, L. E. A. P.; Aguirre, J.; Vazquez Rosas, R.; Suarez, G.; Contreras Ruiz-Esparza, M. G.; Farraz, I.

    2014-12-01

    Methods that use seismic noise or microtremors have become very useful tools worldwide due to its low costs, the relative simplicity in collecting data, the fact that these are non-invasive methods hence there is no need to alter or even perforate the study site, and also these methods require a relatively simple analysis procedure. Nevertheless the geological structures estimated by this methods are assumed to be parallel, isotropic and homogeneous layers. Consequently precision of the estimated structure is lower than that from conventional seismic methods. In the light of these facts this study aimed towards searching a new way to interpret the results obtained from seismic noise methods. In this study, seven triangular SPAC (Aki, 1957) arrays were performed in the city of Coatzacoalcos, Veracruz, varying in sizes from 10 to 100 meters. From the autocorrelation between the stations of each array, a Rayleigh wave phase velocity dispersion curve was calculated. Such dispersion curve was used to obtain a S wave parallel layers velocity (VS) structure for the study site. Subsequently the horizontal to vertical ratio of the spectrum of microtremors H/V (Nogoshi and Igarashi, 1971; Nakamura, 1989, 2000) was calculated for each vertex of the SPAC triangular arrays, and from the H/V spectrum the fundamental frequency was estimated for each vertex. By using the H/V spectral ratio curves interpreted as a proxy to the Rayleigh wave ellipticity curve, a series of VS structures were inverted for each vertex of the SPAC array. Lastly each VS structure was employed to calculate a 3D velocity model, in which the exploration depth was approximately 100 meters, and had a velocity range in between 206 (m/s) to 920 (m/s). The 3D model revealed a thinning of the low velocity layers. This proved to be in good agreement with the variation of the fundamental frequencies observed at each vertex. With the previous kind of analysis a preliminary model can be obtained as a first

  16. Local Site Characterization Using HVSR, ReMi, and SPAC, Study Case: Soccer Field At Autonomous University of Santo Domingo, Dominican Republic

    Science.gov (United States)

    Upegui Botero, F. M.; Rojas Mercedes, N.; Huerta-Lopez, C.; Martinez-Cruzado, J. A.; Suárez, L.; Lopez, A. M.; Huerfano Moreno, V.

    2013-12-01

    Earthquake effects are frequently quantified by the energy liberated at the source, and the degree of damage produced in urban areas. The damage of historic events such as the Mw=8.3, September 19, 1985 Mexico City Earthquake was dominated by the amplification of seismic waves due to local site conditions. The assessment of local site effects can be carried out with site response analyses in order to determine the properties of the subsoil such as the dominant period, and the Vs30. The evaluation of the aforementioned properties is through the analysis of ground motion. However, in locations with low seismicity, the most convenient method to assess the site effect is the analysis of ambient vibration measurements. The Spatial Auto Correlation method (SPAC) can be used to determine a Vs30 model from ambient vibration measurements using a triangular array of sensors. Refraction Microtremor (ReMi) considers the phase velocity of the Rayleigh waves can be separated of apparent velocities; the aim of the ReMI method is to obtain the Vs30 model. The HVSR technique or Nakamura's method has been adopted to obtain the resonant frequency of the site from the calculation of ratio between the Fourier amplitude spectra or PSD spectrum of the horizontal and vertical components of ambient vibration. The aim of this work is to compare the results using different techniques to assess local site conditions in the urban area of Santo Domingo, Dominican Republic. The data used was collected during the Pan-American Advance Studies Institute (PASI), Workshop held in Santo Domingo, Dominican Republic from July 14 to 25, 2013. The PASI was sponsored by IRIS Consortium, NSF and DOE. Results obtained using SPAC, and ReMi, show a comparable model of surface waves velocities. In addition to the above, the HVSR method is combined with the stiffness matrices method for layered soils to calculate a model of velocities and the predominant period on the site. As part of this work a comparison with

  17. Similarity of hydrolyzing activity of human and rat small intestinal disaccharidases

    Directory of Open Access Journals (Sweden)

    Oku T

    2011-06-01

    Full Text Available Tsuneyuki Oku¹, Kenichi Tanabe¹, Shigeharu Ogawa², Naoki Sadamori¹, Sadako Nakamura¹¹Graduate School of Human Health Science, University of Nagasaki, Siebold, Nagayo, Japan; ²Juzenkai Hospital, Kagomachi, Nagasaki, JapanBackground: The purpose of this study was to clarify whether it is possible to extrapolate results from studies of the hydrolyzing activity of disaccharidases from rats to humans.Materials and methods: We measured disaccharidase activity in humans and rats using identical preparation and assay methods, and investigated the similarity in hydrolyzing activity. Small intestinal samples without malignancy were donated by five patients who had undergone bladder tumor surgery, and homogenates were prepared to measure disaccharidase activity. Adult rat homogenates were prepared using small intestine.Results: Maltase activity was the highest among the five disaccharidases, followed by sucrase and then palatinase in humans and rats. Trehalase activity was slightly lower than that of palatinase in humans and was similar to that of sucrase in rats. Lactase activity was the lowest in humans, but was similar to that of palatinase in rats. Thus, the hydrolyzing activity of five disaccharidases was generally similar in humans and rats. The relative activity of sucrose and palatinase versus maltase was generally similar between humans and rats. The ratio of rat to human hydrolyzing activity of maltase, sucrase, and palatinase was 1.9–3.1, but this was not a significant difference. Leaf extract from Morus alba strongly inhibited the activity of maltase, sucrase, and palatinase, but not trehalase and lactase, and the degree of inhibition was similar in humans and rats. L-arabinose mildly inhibited sucrase activity, but hardly inhibited the activity of maltase, palatinase, trehalase and lactase in humans and rats. The digestibility of 1-kestose, galactosylsucrose, and panose by small intestinal enzymes was very similar between humans and

  18. Combining biologic and phototherapy treatments for psoriasis: safety, efficacy, and patient acceptability

    Directory of Open Access Journals (Sweden)

    Farahnik B

    2016-07-01

    Full Text Available Benjamin Farahnik,1 Viraat Patel,2 Kourosh Beroukhim,3 Tian Hao Zhu,4 Michael Abrouk,2 Mio Nakamura,5 Rasnik Singh,3 Kristina Lee,5 Tina Bhutani,5 John Koo5 1University of Vermont College of Medicine, Burlington, VT; 2School of Medicine, University of California, Irvine, 3David Geffen School of Medicine, University of California, Los Angeles, 4University of Southern California Keck School of Medicine, Los Angeles, 5Department of Dermatology, Psoriasis and Skin Treatment Center, University of California, San Francisco, CA, USA Background: The efficacy and safety of biologic and phototherapy in treating moderate-to-severe psoriasis is well known. However, some patients may not respond well to biologic agents or phototherapy on their own and may require combination therapy. Skillfully combining a biologic agent and phototherapy may provide an additive improvement without much increase in risks.Objective: To summarize the current state of evidence for the efficacy and safety of combining biologics with phototherapy in the treatment of moderate-to-severe plaque psoriasis.Methods: We conducted an extensive search on Pubmed database for English language literature that evaluated the use of a combination of biologic and phototherapy for the treatment of moderate-to-severe psoriasis through January 2016. The search included the following keywords: psoriasis, etanercept, adalimumab, infliximab, ustekinumab, biologics, phototherapy, and combination therapy.Results: The primary literature included randomized controlled trials, a head-to-head study, open-label controlled and uncontrolled trials, case series, and case reports. Etanercept was used in over half of the reported cases, but other biologic agents used included ustekinumab, adalimumab, and infliximab. The vast majority of phototherapy was narrowband ultraviolet B (NBUVB radiation. Most cases reported enhanced improvement with combination therapy. Serious adverse events throughout the study duration

  19. New approaches in geological studies of tsunami deposits

    Science.gov (United States)

    Szczucinski, Witold

    2017-04-01

    ., Nishimura Y., Kokociński M., Majewski W., Nakamura Y., Pawlowski J., 2016. Ancient sedimentary DNA reveals past tsunami deposits. Marine Geology 381: 29-33.

  20. Recovery of an evolving magnetic flux rope in the solar wind: Decomposing spatial and temporal variations from single-spacecraft data

    Science.gov (United States)

    Hasegawa, H.; Sonnerup, B.; Hu, Q.; Nakamura, T.

    2013-12-01

    We present a novel single-spacecraft data analysis method for decomposing spatial and temporal variations of physical quantities at points along the path of a spacecraft in spacetime. The method is designed for use in the reconstruction of slowly evolving two-dimensional, magneto-hydrostatic structures (Grad-Shafranov equilibria) in a space plasma. It is an extension of the one developed by Sonnerup and Hasegawa [2010] and Hasegawa et al. [2010], in which it was assumed that variations in the time series of data, recorded as the structures move past the spacecraft, are all due to spatial effects. In reality, some of the observed variations are usually caused by temporal evolution of the structure during the time it moves past the observing spacecraft; the information in the data about the spatial structure is aliased by temporal effects. The purpose here is to remove this time aliasing from the reconstructed maps of field and plasma properties. Benchmark tests are performed by use of synthetic data taken by a virtual spacecraft as it traverses, at a constant velocity, a slowly growing magnetic flux rope in a two-dimensional magnetohydrodynamic simulation of magnetic reconnection. These tests show that the new method can better recover the spacetime behavior of the flux rope than does the original version, in which time aliasing effects had not been removed. An application of the new method to a solar wind flux rope, observed by the ACE spacecraft, suggests that it was evolving in a significant way during the ~17 hour interval of the traversal. References Hasegawa, H., B. U. Ö. Sonnerup, and T. K. M. Nakamura (2010), Recovery of time evolution of Grad-Shafranov equilibria from single-spacecraft data: Benchmarking and application to a flux transfer event, J. Geophys. Res., 115, A11219, doi:10.1029/2010JA015679. Sonnerup, B. U. Ö., and H. Hasegawa (2010), On slowly evolving Grad-Shafranov equilibria, J. Geophys. Res., 115, A11218, doi:10.1029/2010JA015678. Magnetic

  1. IDENTIFICACIÓN DEL AGENTE CAUSAL DE LA ANTRACNOSIS DE Sansevieria spp. EN COSTA RICA

    Directory of Open Access Journals (Sweden)

    Gerardo P\\u00E9rez-Le\\u00F3n

    2013-01-01

    Full Text Available Sansevieria spp. (Agavaceae es una ornamental de follaje originaria de África y Asia. S. trifasciata (St es la especie con mayor número de cultivares en el mercado de exportación de Costa Rica a Estados Unidos y Holanda. Muestras foliares de S. trifasciata var. “Hahnii” con lesiones circulares y acuosas (algunas alargadas y secas, fueron analizadas. El patógeno recuperado fue identificado como Colletotrichum sansevieriae Nakamura (CsN mediante pruebas de patogenicidad, morfología y técnicas moleculares. Los aislamientos mono-hifales presentaron coloración crema, crecimiento postrado y escasa producción de conidios. La patogenicidad de CsN se evaluó en 7 variedades de St; Sansevieriasp., var., jiboia; S. cylindrica y las ornamentalesCodiaeum variegatum, Cordelyne terminalis y Dracaena deremensis, mediante 2 sistemas deinoculación: plantas en maceta (invernaderoy hojas separadas (laboratorio; con ambos sereprodujeron los síntomas de la enfermedad. Cinco de las variedades de S. trifasciata desarrollaron síntomas, “Hahnii” la más susceptible. Ninguna de las otras ornamentales presentósíntomas. CsN fue re-aislado de hojas inoculadas (postulados de Koch. La amplificación mediante PCR de la región ITS con los iniciadores ITS5 e ITS4 produjo un fragmento de aproximadamente 600pb, cuya secuencia de nucleótidos fue idéntica para los aislamientos mono-hifales. En el Banco de Genes, la secuencia alineó con accesiones de CsN de Australia y USA, con un índice de simi laridad del 99 al 100%. El análisis filogenético, con base en la región ITS2, agrupó (99% valor debootstrap los aislamientos costarricenses con elaislamiento tipo CsN de Japón y los de Australia y USA. Hasta donde se conoce, éste es el primer informe de la antracnosis de Sansevieria en C. R.

  2. Development of Strain-Induced Quantum Well Intermixing Technique on InGaP/InAlGaP Laser Structures and Demonstration of First Orange Laser Diode

    KAUST Repository

    Al-Jabr, Ahmad Ali

    2016-08-01

    Laser Diodes (LD) have numerous applications for industry, military, medicine and communications. The first visible LD was invented in 1962 by Nick Holonyak, emitted at 710 nm (red). In 1990s, Shuji Nakamura invented the blue and green Light Emitting Diodes (LED) and later LDs. The production of LDs emitting between 532- 632 nm has been severely lagging behind the rest of the visible spectrum. Yellow and orange LDs are still not accessible due to the lack of successfully grown material with high optical efficiency. AlGaInP is the quaternary compound semiconductor used to grow green to red LEDs and red LDs. At a material composition that is supposed to lase below 630 nm, the optical efficiency becomes low due to the oxygen-related defects associated with high Al content. The quantum well intermixing (QWI) is a post-growth process that is applied to laser structure to tune the wavelength of laser. Until now, there are limited reports on successful intermixing of InGaP/InAlGaP laser structures while maintaining the crystal quality. In this work, we introduced a novel intermixing process that utilizes the high strain induced by the dielectric film during annealing to initiate the intermixing. We deposited SiO2 capping by plasma-enhanced chemical vapor deposition (PECVD) onto the InGaP/InAlGaP laser structure emitting at 635 nm, and then annealed the structure up to 950 Celsius for different periods of time, resulting in an astonishing 100 nm blueshift. This blueshift allowed us to produce an unprecedented shorter wavelength orange lasers emitting at 608 nm. For low degree of intermixing, we have noticed an increase in the intensity of the photoluminescence (PL) signal. The improvement in the PL signal was translated to a reduction in threshold current. We implemented the technique on an LED structure with Al-rich QWs emitting at 590 nm. Significant increase in the PL intensity (20 folds) was observed. By analyzing the improved structure, we observed reduction in oxygen

  3. How to draw down CO2 from severe Hadean to habitable Archean?

    Science.gov (United States)

    Zhelezinskaia, I.; Ding, S.; Mulyukova, E.; Martirosyan, N.; Johnson, A.; West, J. D.; Kolesnichenko, M.; Saloor, N.; Moucha, R.

    2015-12-01

    -191. [4] Kasting & Ackerman (1986). Science, 234(4782), 1383-1385. [5] Marty (2013). Science, 342(6154), 101-104. [6] Shibuya et al. (2012). EPSL, 321, 64-73. [7] Nakamura & Kato (2004). Geoch. et Cosm. Acta, 68(22), 4595-4618. [8] Hargraves (1986). Geology, 14(9), 750-752. [9] Valley et al. (2014), Nature Geoscience 7, 219-223

  4. Geoscience Program for High School Education: the Liceo Magrini Microzonation Experience (Liceo Scientifico Statale "Luigi Magrini", Gemona del Friuli, Udine, Italy)

    Science.gov (United States)

    Barnaba, Carla; Contessi, Elisa; Girardi, Mariarosa

    2013-04-01

    elaborated the collected data, following standard procedures (i.e. Nakamura technique) used in seismology for such kind of investigations. Their findings proved that during a seismic event the effect at sites can be different at depending on theri resonance frequency site. After finding the resonance frequency they observed that common features can be found on soft soil site, with low amplifications in the frequency band 1-2 Hz, while rock site show flat response for all frequencies. That is in agreement with what is already known from literature.

  5. Efficacy and visual prognostic factors of intravitreal bevacizumab as needed for macular edema secondary to central retinal vein occlusion

    Directory of Open Access Journals (Sweden)

    Hirose M

    2014-11-01

    Full Text Available Miki Hirose, Wataru Matsumiya, Shigeru Honda, Makoto NakamuraDepartment of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Chuo-ku, Kobe, Hyogo, JapanPurpose: Our aim was to investigate the efficacy and prognostic factors of intraocular injections of bevacizumab as needed in patients with macular edema secondary to central retinal vein occlusion (CRVO.Methods: This is a retrospective study including 28 eyes of 27 consecutive patients with macular edema due to CRVO and followed for at least 6 months. The mean age of the patients was 66.3 years. The patients underwent an intravitreal injection of bevacizumab (1.25 mg at the initial visit. Retreatments were performed when macular edema was persistent or worsened (as-needed regimen. The primary outcome measure was the mean change in best-corrected visual acuity (BCVA. The change in central retinal thickness (CRT was evaluated as the secondary outcome. Finally, the factors useful for predicting BCVA outcome were determined.Results: The mean number of injections was 1.8 over a period of 6 months. The mean BCVA (logarithm of minimum angle of resolution was significantly improved at 1 (-0.097, 3 (-0.14, and 6 months (-0.25 after the initial injection (P<0.05, <0.01, and <0.001, respectively. The mean CRT was also improved significantly at 1 (-250.4, 3 (-150.0, and 6 months (-187.2 (P<0.001 each. Earlier treatment and better improvement in BCVA at 1 month after the initial treatment were the prognostic factors significantly associated with better visual outcomes at 6 months (P=0.047 and 0.029, respectively.Conclusion: Intravitreal injection of bevacizumab as needed significantly improved visual acuity and macular edema in CRVO patients. Time before the treatment and early response to the treatment were important factors for the visual outcome.Keywords: central retinal vein occlusion, bevacizumab, macular edema, efficacy, prognostic factor, pro re nata regimen

  6. Spectral ratios of ambient noise based on the diffuse field theory: Improved inversion of H/V in layered media using analytical properties of Green functions

    Science.gov (United States)

    Sanchez-Sesma, F. J.; Perton, M.; Piña, J.; Luzón, F.; Garcia-Jerez, A.; Rodriguez-Castellanos, A.

    2013-12-01

    It is well know the popularity of H/V spectral ratio to extract the dominant frequency of soil sites for microzonation studies (Nakamura, 1989). It is relatively easy to make measurements as only one station is needed. Despite its success, this approach had not solid theoretical basis until a proposal to link ambient noise vibrations with diffuse field theory was made (Sánchez-Sesma et al, 2011a). Based on this theory the average spectral density of a given motion of a point, also called directional energy density (Perton et al, 2009), is proportional to the imaginary part of Green function precisely at the observation point. The proportionality implies that vector components are all multiplied by the current spectral level of the diffuse illumination. Appropriate normalization is crucial to make the experimental spectral ratios closer to the theoretical counterpart. According to this theory the square of H/V is twice the ratio of ImG11 and ImG33, where ImG11 and ImG33 are the imaginary part of Green functions at the load point for horizontal and vertical components, respectively. From ImG11 it could be possible through Fourier analysis to extract pseudo reflections and thus constrain the inversion of soil profile. We propose to assess ImG11 removing the influence of illumination spectrum using the H/V spectral ratio and an estimate of ImG33 (obtained from a priori model) by means of ImG11=0.5(H/V)2*ImG33. It has been found that ImG33 is less sensitive to details of stratigraphy. In fact, the most relevant property is the Poisson ratio of the uppermost layer which controls the slope in high frequency (Sánchez-Sesma et al, 2011b). Pseudo-reflection seismograms are thus obtained from Fourier transform, back to time domain, of i{ImG11-ImG11HSS}, where ImG11HSS is the imaginary part of Green functions at the load point for horizontal load at the surface of a half-space with the properties of the uppermost layer. With the obtained model ImG33 can be updated and the

  7. PREFACE: Tenth International Conference on Topics in Astroparticle and Underground Physics (TAUP2007)

    Science.gov (United States)

    Inoue, Kunio; Suzuki, Atsuto; Mitsui, Tadao

    2008-07-01

    The tenth meeting of the TAUP Workshop Series, TAUP 2007, was organized by the Research Center for Neutrino Science, Tohoku University. In TAUP 2007 all the various aspects of Astroparticle Physics have been covered, from Cosmology and Dark Constituents, to Gravitational Waves, to Neutrino Physics and Astrophysics, to High Energy Astrophysics, to Cosmic Rays and Gamma-Rays Astronomy. New and important scientific results were presented and debated in the plenary review talks and in a very large number of contributions in topical parallel sessions. As editors of these proceedings, we hope that this volume, which contains most of the talks and contributions presented at TAUP 2007, will provide a detailed state-of-the-art account of the various facets of Astroparticle Physics. We thank all the invited speakers, conveners, and contributors who made this possible. Full coverage of the transparencies presented at the conference can be found on the website http://www.awa.tohoku.ac.jp/taup2007. The TAUP 2007 Organizing Committee thanks IUPAP/PaNAGIC, Sendai Tourism and Convention Bureau, COE program: Exploring New Science by Bridging Particle-Matter Hierarchy, SEIKO EG&G, and REPIC corporation for sponsoring the Conference, and Sendai Civic Auditorium, where the meeting was held, for their hospitality. We wish to thank Alessandro Bottino, Junpei Shirai, Fumihiko Suekane, David Sinclair, Takaaki Kajita, Takeo Moroi, Masaki Mori, Masahiro Kawasaki, Yoshihito Gando, Sei Yoshida, Kyoko Tamae, Sanshiro Enomoto, Alexandre Kozlov, Yasuhiro Kishimoto, Itaru Shimizu, Kengo Nakamura, Haruo Ikeda, and Kyo Nakajima for their invaluable contribution in the scientific shaping of the conference and in the preparation of the present volume. The Organizing Committee is grateful to the members of the International Advisory Committee and of the TAUP Steering Committee for assistance and advice on the scientific program. Very special thanks are due to Ms Rika Bizen, Mr Fujio Miura, Ms Akemi

  8. PREFACE: The 16th International Symposium on Boron, Borides and Related Materials (ISBB 2008)

    Science.gov (United States)

    Tanaka, Takaho

    2009-07-01

    supported by Tokyo University of Science, Suwa and foundations including, the Kajima Foundation, Foundation for Promotion of Material Science and Technology of Japan and Nippon Sheet Glass Foundation for Materials Science and Engineering, as well as companies including JFE Steel Corporation, Shincron Co, Ltd, Toyo Kohan Co, Ltd, Fukuda Metal Foil and Powder Co, Ltd, Japan New Metals Co, Ltd, H C Starck Ltd and Fritsch Japan Co, Ltd. Editors Chair Takaho Tanaka (National Institute for Materials Science, Japan) Vice chairs Koun Shirai (Osaka University, Japan) Kaoru Kimura (The University of Tokyo, Japan) Ken-ichi Takagi (Tokyo City University, Japan) Touetsu Shishido (Tohoku University, Japan) Shigeru Okada (Kokushikan University) Hideaki Itoh (Nagoya University,Japan) Katsumitsu Nakamura (Nihon University, Japan) Organizing committee of ISBB 2008 K Takagi Chairman (Tokyo City University) T Tanaka Program Committee Chairman (National Institute for Materials Science) K Kimura Secretary (The University of Tokyo) J Akimitsu (Aoyama University)K Shirai (Osaka University) H Itoh (Nagoya University)T Shishido (Tohoku University) K Nakamura (Nihon University)K Soga (Tokyo University of Science) K Nishiyama (Tokyo University of Science, Suwa)M Takeda (Nagaoka University of Technology) S Okada (Kokushikan University)Y Yamazaki (Toyo Kohan Co, Ltd) International Scientific Committee 0f ISBB (2008-2011) K Takagi Chairman (Japan) B Albert (Germany) J-F Halet (France) M Takeda (Japan) M Antadze (Georgia) H Hillebrecht (Germany) T Tanaka (Japan) J Bauer (France) W Jung (Germany) R Telle (Germany) I Boustani (Germany) K Kimura (Japan) M Trenary (USA) D Emin (USA) T Mori (Japan) O Tsagareishvili (Georgia) M Engler (Germany) P D Ownby (USA) H Werheit (Germany) N Frage (Israel) P Rogl (Austria) G Will (Germany) Yu Grin (Germany) S Shalamberidze (Georgia) O Yucel (Turkey) V N Gurin (Russia) N Shitsevalova (Ukraine) G Zhang (China)

  9. Geology, mineralization and geochemistry of the Aqkand Cu occurrence (north of Zanjan, Tarom-Hashtjin zone

    Directory of Open Access Journals (Sweden)

    Maryam Feyzi

    2017-02-01

    , fluorite and chlorite are present in the gangue minerals that represent vein-veinlet, breccia, vug infill, replacement, colloform, cockade, crustiform and plumose textures. Comparison of Chondrite normalized (Nakamura, 1974 REE patterns of Eocene fresh and barren andesitic basalt lavas, Oligocene rhyolitic-rhyodacitic lavas and the mineralized samples at Aqkand indicate that ore-forming fluids are probably related to Oligocene rhyolitic-rhyodacitic lavas. However, leaching of some elements from the host andesitic basalt lavas may have also been involved in mineralization. The geological, mineralogical, geochemical, textural and structural characteristics of the Aqkand occurrence reveals that copper mineralization at Aqkand is an example of epithermal base metal mineralization within the Tarom-Hashtjin zone. Acknowledgements The authors are grateful to the University of Zanjan Grant Commission for research funding. Mr. A.A. Atashnema is also appreciated for his help during the field work. Journal of Economic Geology reviewers and editor are also thanked for their constructive suggestions on alterations to the manuscript. References Davies, R.G., 1977. Geological map of Bandar-e-Anzali, scale 1:250,000. Geological Survey of Iran. Faridi, M. and Anvari, A., 2000. Geological map of Hashtjin, scale 1:100,000. Geological Survey of Iran. Hirayama, K., Samimi, M., Zahedi, M. and Hushmand-Zadeh, A., 1966. Geology of the Tarom District, Western Part (Zanjan area north-west Iran, Geological Survey of Iran, Tehran, Report 8, 31 pp. Nakamura, N., 1974. Determination of REE, Ba, Fe, Mg, Na and K in carbonaceous and ordinary Chondrites. Geochimica et Cosmochimica Acta, 38(5: 755–773.

  10. Petrography, Geochemistry and Petrogenesis of Volcanic Rocks, NW Ghonabad, Iran

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    Sedigheh Zirjanizadeh

    2016-07-01

    .6mmin size. Trachyte is characterized by trachytic texture. Ninety percent of the rock consists of sanidine. In trachytes, 3 to 5% hornblende ( 0.3 mm is replaced by carbonates. Rhyolites contain quartz, plagioclase, sanidine, and biotite phenocrysts in a microcrystalline to glassy groundmass. Rhyodacitehas phenocrysts, some glomerophyric, consisting of quartz, 2 to 3% (0.1-0.5 mm, plagioclase 7 to 10% (0.2- 0.8 mm, hornblende 5% and biotite 1%. Up to 15% of sanidineis altered to clay minerals. Crystal tuff and lithic-crystal tuff are distributed overa large area. Using the Zr/TiO2 and Nb/Y diagram of Winchester and Fold (1977, samples are designated as rhyolite, dacite and sub-alkaline basalt. In the Co vs. Th diagram of Hastie et al. (2007, samples plot in the shoshonitic and high calc-alkaline, rhyolite, dacite and andesite-basalt fields. The REE patterns and trace element contents of the volcanic samples show: (1 LREE/HREE enrichment ((La/Yb N = 0.3 to 15.27, (2 Low negative Eu anomaly (ave.Eu*/Eu=0.2-0.85, (3 depletion in Ba, Sr, K2O, Zr and Ti (Lower continental crust-normalized spider diagram from Taylor and McLennan, 1985 and Chondrite-normalized diagram from Nakamura, 1974. Rhyolites show the most extreme negative Eu anomaly (Eu/Eu* = 0.2-0.3 compared with 0.65–0.85 for volcanic elsewhere and also show considerably differences in the contents of Rb,Sr,K,Ti,Zr,Hf,Ce. These differences are related to greater magmatic differentiation or derivation from the other sources. The Sr and Nd isotopic ratios of these volcanic rocks are: 87Sr/86Sr = 0.70699 to 0.71014 and 143Nd/144Nd =0.512144 to 0.512539. Assuming an age of 60 Ma, the initial 87Sr/86Sr ratios vary from 0.70671 to 0.71066 and initial 143Nd/144Nd values vary from 0.512098 0.51249 (εNdi = -9.1 to 0.51249 (εNdi = -1.4.In the εNdi versus (87Sr/86Sri diagram, the samples plot in the field typical of magmas that are of crustal origin or, at least, that underwent important processes of crustal assimilation

  11. Characterization of site-effects in the urban area of Canakkale, Turkey, using ambient noise measurements

    Science.gov (United States)

    Demirci, Alper; Bekler, Tolga; Karagöz, Özlem

    2010-05-01

    The local site conditions can cause variations in the ground motion during the earthquake events. These local effects can be estimated by Nakamura method (1989) which is based on the analysis and treatment of earth vibration records by calculating the ratio of horizontal spectrum to vertical spectrum (H/V). This approach uses ambient noises and aids to estimate the dynamic soil conditions like fundamental vibration period and soil amplification of the surface layers, to characterize the seismic hazard during earthquakes and to provide detailed information for seismic microzonation in small scale urban areas. Due to these advantages, the method has been frequently used by a great number of seismologists and engineers. In this study, we aimed at explaining the soil conditions in Çanakkale and Kepez basins by using H/V technique. Çanakkale and Kepez (NW, Turkey) have fairly complex tectonic structure and have been exposed to serious earthquake damages in historical and instrumental period. Active faults, which have influence on the Çanakkale and Kepez settlements, are the Yenice-Gönen fault, Saroz-Gaziköy fault and Etili fault. It is well known that, these faults have produced high magnitude earthquakes such as 7.2 in 1912 and 7.3 in 1953. The surface geology of the surveyed area is covered by quaternary aged sediments. Sarıçay river, which originates from the eastern hilly area, accumulates sediment deposits and forms this alluvial basin. Considering the geological conditions, ambient noises were recorded at 88 measurement points which were selected to provide good coverage of the study area. All records were acquired during the midnight (between 1:00 am and 6:00 am) to reduce the artificial effects in the urban area. Taking into account the effects of undesirable traffic and industrial noises in the vicinity of measurements stations, record lengths were chosen in the range of 25-75 minutes with the sampling rate of 100 Hz. Once the required signal processes

  12. Book Reviews

    Directory of Open Access Journals (Sweden)

    Redactie KITLV

    2002-04-01

    University Press, xiv + 299 pp. [Yale Southeast Asia studies monograph 48.] 1999 -Bernice de Jong Boers, Peter Just, Dou Donggo justice; Conflict and morality in an Indonesian society. Lanham, Maryland: Rowman and Littlefield, 2001, xi + 263 pp. -Nico J.G. Kaptein, Howard M. Federspiel, Islam and ideology in the emerging Indonesian state; The Persatuan Islam (PERSIS, 1923 to 1957. Leiden: Brill, 2001, xii + 365 pp. -Gerrit Knaap, Els M. Jacobs, Koopman in Azië; De handel van de Verenigde Oost-Indische Compagnie tijdens de 18de eeuw. Zutphen: Walburg Pers, 2000, 304 pp. -Toon van Meijl, Bruce M. Knauft, From primitive to postcolonial in Melanesia and anthropology. Ann Arbor: University of Michigan Press, 1999, x + 320 pp. -Jennifer Nourse, Juliette Koning ,Women and households in Indonesia; Cultural notions and social practices. Richmond, Surrey: Curzon, 2000, xiii + 354 pp., Marleen Nolten, Janet Rodenburg (eds -Sandra Pannell, Clayton Fredericksen ,Altered states; Material culture transformations in the Arafura region. Darwin: Northern Territory University Press, 2001, xiv + 160 pp., Ian Walters (eds -Anne Sofie Roald, Alijah Gordon, The propagation of Islam in the Indonesian-Malay archipelago. Kuala Lumpur: Malaysian sociological research institute, 2001, xxv + 472 pp. -M.J.C. Schouten, Mary Taylor Huber ,Gendered missions; Women and men in missionary discourse and practice. Ann Arbor: The University of Michigan Press, 1999, x + 252 pp., Nancy C. Lutkehaus (eds -Karel Steenbrink, Nakamura Mitsuo ,Islam and civil society in Southeast Asia. Singapore: Institute of Southeast Asian studies, 2001, 211 pp., Sharon Siddique, Omar Farouk Bajunid (eds -Heather Sutherland, Robert Cribb, Historical atlas of Indonesia, Richmond, Surrey: Curzon, 2000, x + 256 pp. -Sikko Visscher, Lee Kam Hing ,The Chinese in Malaysia. Kuala Lumpur: Oxford University Press, 2000, xxix + 418 pp., Tan Chee-Beng (eds -Edwin Wieringa, Jane Drakard, A kingdom of words; Language and power in Sumatra. Kuala

  13. Investigation of the association between the GLC3A locus and normal tension glaucoma in Japanese patients by microsatellite analysis

    Directory of Open Access Journals (Sweden)

    M Kamio

    2009-01-01

    Full Text Available M Kamio1*, A Meguro1*, M Ota2, N Nomura1, K Kashiwagi3, F Mabuchi3, H Iijima3, K Kawase4, T Yamamoto4, M Nakamura5, A Negi5, T Sagara6, T Nishida6, M Inatani7, H Tanihara7, M Aihara8, M Araie8, T Fukuchi9, H Abe9, T Higashide10, K Sugiyama10, T Kanamoto11, Y Kiuchi11, A Iwase12, S Ohno13, H Inoko14, N Mizuki11Department of Ophthalmology, Yokohama City University School of Medicine, Yokohama, Kanagawa, Japan; 2Department of Legal Medicine, Shinshu University School of Medicine, Matsumoto, Nagano, Japan; 3Department of Ophthalmology, University of Yamanashi, Faculty of Medicine, Yamanashi, Japan; 4Department of Ophthalmology, Gifu University Graduate School of Medicine, Gifu, Japan; 5Department of Surgery, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Hyogo, Japan; 6Department of Ophthalmology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan; 7Department of Ophthalmology and Visual Science, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan; 8Department of Ophthalmology, University of Tokyo School of Medicine, Tokyo, Japan; 9Division of Ophthalmology and Visual Science, Graduated School of Medical and Dental Sciences, Niigata University, Niigata, Japan; 10Department of Ophthalmology and Visual Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan; 11Department of Ophthalmology and Visual Science, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan; 12Department of Ophthalmology, Tajimi Municipal Hospital, Tajimi, Gifu, Japan; 13Department of Ophthalmology, Hokkaido University School of Medicine, Sapporo, Japan; 14Department of Genetic Information, Division of Molecular Life Science, Tokai University School of Medicine, Isehara, Kanagawa, Japan; *These authors contributed equally to this reportPurpose: To investigate whether the GLC3A locus harboring the CYP1B1 gene is associated with normal tension glaucoma

  14. Use of Lagrangian transport models and Sterilized High Volume Sampling to pinpoint the source region of Kawasaki disease and determine the etiologic agent

    Science.gov (United States)

    Curcoll Masanes, Roger; Rodó, Xavier; Anton, Jordi; Ballester, Joan; Jornet, Albert; Nofuentes, Manel; Sanchez-Manubens, Judith; Morguí, Josep-Anton

    2015-04-01

    quartz filters and sterilized polycarbonate membrane filters were used on sampling. Sterility conditions were required in all the processes from the preparation of the equipment, the sampling, and the later manipulation of the filter and instrumentation. The methodology used to find the possible etiological agents sources for KD cases in Japan has been extrapolated to other regions worldwide as Catalonia. In Catalonia, in the last 10 years, an average of 40 cases of KD per year are detected. Taking in consideration that in Catalonia there is a lack of a predominant strong wind or synoptic situation with high energy associated, the possible source regions of etiological agents could be much more closer to the receptors than in Japan. Therefore we have used higher resolution models for the backward simulations and a different sampling methodology based on ground measurements. References Rodó X, Curcoll R, Robinson M, Ballester J, Burns JC, Cayan,...Morguí J-A (2014) Tropospheric winds from northeastern China carry the etiologic agent of Kawasaki disease from its source to Japan. Proceedings of the National Academy of Science of the U S A, 11(22), 7952-4957 Rodo X, Ballester J, Cayan D, Melish M, Nakamura Y, et al (2011) Association of Kawasaki disease with tropospheric wind patterns. Nature Scientific Reports 1, Article Number 152 doi: 10.1038/srep00152 Stohl A, Forster C, Frank A, Seibert P, Wotawa G (2005) Technical note: The Lagrangian particle dispersion model FLEXPART version 6.2. Atmos Chem Phys 5:2461-2474

  15. Reasons for encounter and diagnoses of new outpatients at a small community hospital in Japan: an observational study

    Directory of Open Access Journals (Sweden)

    Takeshima T

    2014-06-01

    Full Text Available Taro Takeshima,1,2 Maki Kumada,3,4 Junichi Mise,5 Yoshinori Ishikawa,6 Hiromichi Yoshizawa,4 Takashi Nakamura,3,4 Masanobu Okayama,1 Eiji Kajii11Division of Community and Family Medicine, Center for Community Medicine, Jichi Medical University, Shimotsuke, Japan; 2Department of Healthcare Epidemiology, School of Public Health in the Graduate School of Medicine, Kyoto University, Kyoto, Japan; 3Division of The Project for Integration of Community Health, Center for Community Medicine, Jichi Medical University, Shimotsuke, Japan; 4Department of General Internal Medicine, Chikusei City Hospital, Chikusei, Japan; 5Division of Human Resources Development for Community Medicine, Center for Community Medicine, Jichi Medical University, Shimotsuke, Japan; 6Department of Surgery, Chikusei City Hospital, Chikusei, JapanPurpose: Although many new patients are seen at small hospitals, there are few reports of new health problems from such hospitals in Japan. Therefore, we investigated the reasons for encounter (RFE and diagnoses of new outpatients in a small hospital to provide educational resources for teaching general practice methods.Methods: This observational study was conducted at the Department of General Internal Medicine in a small community hospital between May 6, 2010 and March 11, 2011. We classified RFEs and diagnoses according to component 1, “Symptoms/Complaints”, and component 7, “Diagnosis/Diseases”, of the International Classification of Primary Care, 2nd edition (ICPC-2. We also evaluated the differences between RFEs observed and common symptoms from the guidelines Model Core Curriculum for Medical Students and Goals of Clinical Clerkship.Results: We analyzed the data of 1,515 outpatients. There were 2,252 RFEs (1.49 per encounter and 170 ICPC-2 codes. The top 30 RFE codes accounted for 80% of all RFEs and the top 55 codes accounted for 90%. There were 1,727 diagnoses and 196 ICPC-2 codes. The top 50 diagnosis codes accounted for

  16. Relationships between fat deposition in the liver and skeletal muscle and insulin sensitivity in Japanese individuals: a pilot study

    Directory of Open Access Journals (Sweden)

    Eiichi Yoshimura

    2011-01-01

    Full Text Available Eiichi Yoshimura1,2, Hideaki Kumahara3, Takuro Tobina4, Sakiko Matono1, Akira Kiyonaga4, Miyuki Kimura5, Hiroshi Tsukikawa6, Shinya Kono6, Takashi Etou5, Shin Irie5, Keizo Anzai7, Hiroaki Tanaka41Graduate School of Sports and Health Science, Fukuoka University, Fukuoka, Japan; 2Faculty of Medicine, Fukuoka University, Fukuoka, Japan; 3Faculty of Nutrition Sciences, Nakamura Gakuen University, Fukuoka, Japan; 4Faculty of Sports and Health Science, Fukuoka University, Fukuoka, Japan; 5Kyushu Clinical Pharmacology Research Clinic, Fukuoka, Japan; 6PS Clinic, Fukuoka, Japan; 7Saga University Hospital, Saga, JapanPurpose: To evaluate the relationships between insulin sensitivity (IS, body fat accumulation, and aerobic capacity in middle- to older-aged Japanese participants with visceral adiposity.Participants and methods: Aerobic capacity was measured during an incremental ramp exercise test. Computed tomography was used to measure visceral (VFA and subcutaneous (SFA fat area, the fat in liver-to-spleen ratio (L/S, and low-density skeletal muscle area (LDMA. IS was assessed using euglycemic-hyperinsulinemic clamps.Results: A total of 11 males and 9 females, age 58 ± 9 years (mean ± standard deviation, body mass index 29 ± 4.1 kg/m2, and VFA 190 ± 53 cm2 participated in this study. In unadjusted models, VFA, LDMA, and L/S were significantly correlated with IS, which remained in adjusted models for LDMA and L/S, but not for VFA. In multiple stepwise regression analysis including sex, age, body fat, VFA, SFA, alcohol consumption, and aerobic capacity (oxygen uptake at the lactate threshold, L/S, and LDMA accounted for 70% of the total variance in IS. Percentage body fat and SFA, but not VFA, were significantly correlated with high molecular-weight adiponectin levels (r = 0.58, P < 0.01 and r = 0.54, P < 0.05, respectively. IS and L/S were significantly and negatively correlated with tumor necrosis factor-α (r = -0.67 and -0.63, respectively; both P

  17. Trace-Element Constraints on Origin of SiO2-bearing Clasts in Ordinary Chondrites

    Science.gov (United States)

    Misawa, K.; Kanazawa, M.; Bridges, J. C.; Nakamura, N.; Hutchison, R.

    1995-09-01

    produced by igneous fractionation controlled by the plagioclase component. Extensive olivine extraction followed plagioclase crystallization from the residua may be able to explain the REE pattern of CB8 [5, 6]. However, simple fractional crystallization or extraction of partial melting liquid from a chondritic source could explain neither large fractionation of La/Lu nor enrichment of Eu relative to Sr observed in CB1, CB4, and CB7. Detailed fractionation processes occurred on a parent body still remain unsolved. References: [1] Olsen E. J. et al. (1981) EPSL, 56, 82-88. [2] Brigham C. A. et al. (1986) GCA, 50, 1655-1666. [3] Nakamura N. et al. (1990) EPSL, 99, 290-302. [4] Bridges J. C. et al. (1993) Meteoritics, 28, 329-330. [5] Bridges J. C. et al. (1994) Meteoritics, 29, 448-449. [6] Bridges J. C. et al. (1995) Meteoritics, submitted. [7] Ruzicka A. et al. (1995) Meteoritics, 30, 57-70.

  18. Effect of chain extension on rheology and tensile properties of PHB and PHB-PLA blends

    Science.gov (United States)

    Bousfield, Glenn

    Poly(3-hydroxybutyrate), referred to as PHB, is a bacterially-synthesized and biodegradable polymer which is being considered as a substitute for non-biodegradable bulk polymers like polypropylene. PHB is naturally extremely isotactic and naturally has a very high degree of crystallinity, resulting in a stiff but brittle material. The stability of PHB crystals also means that the melting point of the polymer is approximately 170°C, high with respect to similar polymers. For instance, the melting point of poly(4-hydroxybutyrate) is only 53°C (Saito, Nakamura, Hiramitsu, & Doi, 1996). Above 170°C, PHB is subject to a thermomechanical degradation mechanism, meaning that the polymer cannot be melted without degrading. One possible solution to the problem of degradation is to add a chain extender to the molten polymer to increase average molecular weight to counteract the molecular weight lost to degradation. In this work, a variety of chain extenders (JoncrylRTM ADR 4368-C, pyromellitic dianhydride, hexamethylene diisocyanate, polycarbodiimide) were compounded with a random copolymer of 98 mol% 3-hydroxybutyrate and 2 mol% 3-hydroxyvalerate (referred to as PHB) in concentrations ranging from 0.25% to 4%, to determine which chain extender functionality worked best with PHB. Molecular weight change was inferred from torque monitored during compounding, and from complex viscosity determined from parallel-plate rheology. None of the chain extenders changed the rate of degradation of PHB, although Joncryl increased the complex viscosity of the polymer. PHB was also blended with Poly(L-lactic acid), referred to as PLLA in PHB/PLLA ratios of 100/0, 75/25, 50/50, 25/75 and 0/100, to determine the effect of blending on the thermal stability of PHB. Again, thermal stability was determined by monitoring torque during compounding and by measuring complex viscosity through parallel-plate rheology. Blends in which PHB was the more abundant phase, as well as the 50% PHB/50% PLA

  19. Tectonic background of a unique hydrogen-rich Kairei Hydrothermal Field, Central Indian Ridge: Results from Taiga Project

    Science.gov (United States)

    Okino, K.; Nakamura, K.; Morishita, T.; SATO, H.; Sato, T.; Mochizuki, N.; Okamura, K.; Fukuba, T.; Sunamura, M.

    2012-12-01

    The Central Indian Ridge (CIR) is slow~intermediate spreading systems and its southern end forms a R-R-R triple junction with SWIR and SEIR. The southern CIR shows slow-spreading morphology, where the axial valley develops along the ridge crest and an oceanic core complex has been reported near the triple junction. Kairei Hydrothermal Field (KHF) is unique hydrothermal system, located at the southern end of CIR. The fluids venting from the KHF are characterized by its high concentration of hydrogen with low methane/hydrogen ratio, and a hydrogen-based hyperthermophilic subsurface lithoautotrophic microbial ecosystem was confirmed (Takai et al., 2004). The KHF lies on basaltic lava area on the shoulder of ridge axial wall, being different from other hydrogen-rich hydrothermal fields hosted by ultramafic rocks. We selected this area as an integrated site for the Taiga Project, and conducted series of research cruises to characterize this unique system and to understand how the tectonic setting controls the fluid and ecosystem. We discover that the KHF itself is located above basaltic lava field but gabbro and ultramafic rocks are widely exhumed around the KHF. Besides a previously known oceanic core complex, small oceanic core complexes exist just east of the KHF (Kumagai et al., 2008) and the NTO massif north of the KHF shows peridotite exposure on its top. The unique fluid geochemistry of the KHF can be attributed to serpentinization of troctolites around or beneath the KHF and subsequent hydrothermal reactions with basaltic wall rocks (Nakamura et al., 2009). We also find several small hills where we collect deep crustal and mantle rocks. These hills suggesting melt-limited environment extend mainly along 2nd order segment boundary from the axial valley to 30km off-axis, i.e. ~1.7 Ma. The regional surface geophysical mapping and deep-tow magnetic profiling show high mantle Bouguer anomaly and prominent asymmetric spreading in the southernmost CIR segment. These

  20. Microzonation Studies In District of Dikili, Izmir (Turkey) In The Context of Social Responsibility by Using GIS Tecniques

    Science.gov (United States)

    Karabulut, Savas; Cinku, Mualla; Tezel, Okan; Hisarli, Mumtaz; Ozcep, Ferhat; Tun, Muammer; Avdan, Ugur; Ozel, Oguz; Acikca, Ahmet; Aygordu, Ozan; Benli, Aral; Kesisyan, Arda; Yilmaz, Hakan; Varici, Cagri; Ozturkan, Hasan; Ozcan, Cuneyt; Kivrak, Ali

    2015-04-01

    bearing capacity, soil amplification), c) The basin structure and possible fault of the Dikili district, d) Risk analysis on cultivated areas due to salty water injection, e) The tectonic activity of the study area from Miocene to present. During this study a number of measurements were carried out to solve the problems defined above. These measurements include; microtremor single station (H/V) method according to Nakamura's technique, which is applied at 222 points. The results provide maps of soil fundamental frequency, soil amplification and soil sedimentary thickness by using developed amprical relationships. Spatial Autocorrelation Technique (SPAC) was carried out in 11 sites with Guralp CG-5 seismometer to predict the shear wave velocity-depth model towards the sismological bedrock. Multi-channel analysis of Surface Wave (MASW), Microtremor Array Method (MAM) and Seismic Refraction Method were applied at 121 sites with SARA-Doremi Seismograph. The soil liquefaction-induced settlements are determined in the frame of shallow soil engineering problems. Vertical Electrical Sounding (VES) was carried out to define the presence of saltly and drinkable and hot/cold underground water, the location of possible faults and the bedrock depth which was estimated with a Scientrex Saris Resistivity Equipment. To define the areas which are influenced by salty water, induced polarization (IP) method was applied at 34 sites. The basin structure and the probably faults of the study area were determined by applying gravity measurements on 248 points with a CG-5 Autogravity meter. Evaluation of the combined data is very important for producing microzonation maps. We therefore integrated all of the data into the GIS database and prepared large variety of maps.

  1. IHG: an Integrated Hydrological-Geotechnical model for large landslides' susceptibility assessments

    Science.gov (United States)

    Passalacqua, R.; Bovolenta, R.

    2012-04-01

    70 positions and, additionally, an array set-up of six seismic stations allowed the study of the Rayleigh and Love wave dispersion. Thus, by using the well known Nakamura's technique, the overall spread of the bedrock depths was finally obtained. Because of a rather large territorial dimension, the relevant issues were into finding the most proper techniques to assess an affordable but reliable site recognition over all its extension, as well as to spatially distribute both the loose-soils' depths information and the pertinent geotechnical/hydrological parameters, which are usually gathered at spot locations. The entire sets of data were spatially distributed, by selecting the appropriate interpolators among those normally available within a Geographical Information System (GIS) platform. GIS is a very useful and effective tool to integrate and analyze georeferenced information, thus allowing wide scale monitoring, management, planning, and supporting risk analyses. In particular, the overall model was developed using a free-open-source GIS environment (GRASS), which permit the direct implementation of additional features, which can then be re-used and updated by its worldwide Users' Community. The whole watershed was tested, in order to better understand the zone from the hydrological point of view. The steady groundwater table was obtained by applying a suitable model to the extensive zone. Within this Conference, the Authors shall present the details of the most recent research development which have been attained on this site's model. It consist into the on-GIS implementation of an Integrated Hydrological-Geotechnical method of analysis (IHG), which allows to obtain (1) the groundwater's level variations, due to selected rain histories, and (2) the spatially distributed susceptibility of the loose-soils' deposit to slide. The IHG model's behavior shows a good conceptual fit with the ground level's movements, which were rendered by a Permanent Scatterers

  2. Immunization of rabbits with synthetic peptides derived from a highly conserved β-sheet epitope region underneath the receptor binding site of influenza A virus

    Directory of Open Access Journals (Sweden)

    Ideno S

    2013-11-01

    Full Text Available Shoji Ideno,1,3 Kaoru Sakai,1 Mikihiro Yunoki,2–4 Ritsuko Kubota-Koketsu,3,5 Yuji Inoue,3 Shota Nakamura,6 Teruo Yasunaga,6 Yoshinobu Okuno,5 Kazuyoshi Ikuta3 1Infectious Pathogen Research Section, Central Research Laboratory, Research and Development Division, Japan Blood Products Organization, Kobe, Japan; 2Research and Development Promotion Section, Research and Development Division, Japan Blood Products Organization, Tokyo, Japan; 3Department of Virology, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan; 4Department of Veterinary Microbiology, School of Veterinary Medicine, Rakuno Gakuen University, Ebetsu, Hokkaido, Japan; 5Kanonji Institute, The Research Foundation for Microbial Diseases of Osaka University, Kanonji, Kagawa, Japan; 6Department of Genome Informatics, Genome Information Research Center, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan Background: There is increasing concern about the speed with which health care providers can administer prophylaxis and treatment in an influenza pandemic. Generally, it takes several months to manufacture an influenza vaccine by propagation of the virus in chicken eggs or cultured cells. Newer, faster protocols for the production of vaccines that induce broad-spectrum immunity are therefore highly desirable. We previously developed human monoclonal antibody B-1 that shows broadly neutralizing activity against influenza A virus H3N2. B-1 recognizes an epitope region that includes an antiparallel β-sheet structure underneath the receptor binding site of influenza hemagglutinin (HA. In this study, the efficacy of a synthetic peptide vaccine derived from this epitope region against influenza A was evaluated. Materials and methods: Two peptides were synthesized, the upper and lower peptides. These peptides comprise amino acid residues 167–187 and 225–241, respectively, of the B-1 epitope region of HA, which is involved in

  3. SCAPS, a two-dimensional ion detector for mass spectrometer

    Science.gov (United States)

    Yurimoto, Hisayoshi

    2014-05-01

    , 82-85. [2] Takayanagi et al. (1999) Proc. 1999 IEEE workshop on Charge-Coupled Devices and Advanced Image Sensors, 159-162. [3] Kunihiro et al. (2001) Nucl. Instrum. Methods Phys. Res. Sec. A 470, 512-519. [4] Nagashima et al. (2001) Surface Interface Anal. 31, 131-137. [5] Takayanagi et al. (2003) IEEE Trans. Electron Dev. 50, 70- 76. [6] Sakamoto and Yurimoto (2006) Surface Interface Anal. 38, 1760-1762. [7] Yamamoto et al. (2010) Surface Interface Anal. 42, 1603-1605. [8] Sakamoto et al. (2012) Jpn. J. Appl. Phys. 51, 076701. [9] Yurimoto et al. (2003) Appl. Surf. Sci. 203-204, 793-797. [10] Nagashima et al. (2004) Nature 428, 921-924. [11] Kunihiro et al. (2005) Geochim. Cosmochim. Acta 69, 763-773. [12] Nakamura et al. (2005) Geology 33, 829-832. [13] Sakamoto et al. (2007) Science 317, 231-233. [14] Greenwood et al. (2008) Geophys. Res. Lett., 35, L05203. [15] Greenwood et al. (2011) Nature Geoscience 4, 79-82. [16] Park et al. (2012) Meteorit. Planet. Sci. 47, 2070-2083. [17] Hashiguchi et al. (2013) Geochim. Cosmochim. Acta. 122, 306-323.

  4. Study of ion implanted Al0.25Ga0.75As/GaAs by Raman spectroscopy

    Institute of Scientific and Technical Information of China (English)

    LIU; Pijun

    2001-01-01

    [1]Ramam, A., Chua, S. J., Luminescence anomaly in band gap tailored In0.35(GaxAl1-x)0.47As quaternary alloy growth by molecular beam epitaxy, J. Cryst. Growth, 1997, 175: 1294.[2]Xu, X. G., Huang, B. B., Ren, H. W. et al., Study on the stability of GaAs/AlGaAs superlattice structure, Acta Physica Sinica (Overseas Edition), 1995, 4: 47.[3]Yoon, S. F., Miao, Y. B., Radhakrishnan, K., Some characteristic of silicon-doped In0.52Al0.48As grown lattice-matched on InP substrates by molecular beam epitaxy, Thin. Solid Films, 1996, 287: 284.[4]Nakamura, K., Fuyuki, T., Matsunami, H., Strain in GaP films heteroepitaxially grown in Si by Metalorganic Chemical Vapor Deposition, Jan. J. Appl. Phys., 1998, 37: 4231.[5]Sadao Adachi, GaAs, AlAs, and AlxGa1-xAs: Material parameters for use in research and device applications, J. Appl. Phys., 1985, 58: R1.[6]Attolini, G., Francesio, L., Franzosi, P. et al., Raman scattering study of residual strain in GaAs/InP heterostructures, J. Appl. Phys., 1994, 75: 4156.[7]Helmy, A. S., Bryce, A. C., Ironside, C. N. et al., Raman spectroscopy for characterizing compositional intermixing in GaAs/AlGaAs heterostructures, Appl. Phys. Lett., 1999, 74: 3978.[8]Jencic, I., Bench, M. W., Robertson, I. M. et al., A comparison of the amorphization induced in AlxGa1-xAs and GaAs by heavy-ion irradiation, J. Appl. Phys., 1991, 69: 1287.[9]Wickboldt, P., Anastassakis, E., Sauer, R. et al., Raman phonon piezospectroscopy in GaAs: Infrared measurements, Phys. Rev. B, 1987, 35: 1362.[10]Leng, J., Qian, Y., Chen, P. et al., Disorder activated optical modes and the phonon dispersion of AlxGa1-xAs lattice vibration, Solid State Commun., 1989, 69: 311.[11]Wagner, A., Koidl, P., Newman, P. G., Resonance effects in Raman scattering by dopant-induced local vibrational modes in III-V semiconductors, Appl. Phys. Lett., 1991, 59: 1729.[12]Masayuki Sugiura, Masato Kishi, Takashi Katoda, In situ observation of the strain

  5. Using the D-Wave 2X Quantum Computer to Explore the Formation of Global Terrorist Networks

    Energy Technology Data Exchange (ETDEWEB)

    Ambrosiano, John Joseph [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Roberts, Randy Mark [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Sims, Benjamin Hayden [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2017-05-15

    Social networks with signed edges (+/-) play an important role in an area of social network theory called structural balance. In these networks, edges represent relationships that are labeled as either friendly (+) or hostile (-). A signed social network is balanced only if all cycles of three or more nodes in the graph have an odd number of hostile edges. A fundamental property of a balanced network is that it can be cleanly divided into 2 factions, where all relationships within each faction are friendly, and all relationships between members of different factions are hostile. The more unbalanced a network is, the more edges will fail to adhere to this rule, making factions more ambiguous. Social theory suggests unbalanced networks should be unstable, a finding that has been supported by research on gangs, which shows that unbalanced relationships are associated with greater violence, possibly due to this increased ambiguity about factional allegiances (Nakamura et al). One way to estimate the imbalance in a network, if only edge relationships are known, is to assign nodes to factions that minimize the number of violations of the edge rule described above. This problem is known to be computationally NP-hard. However, Facchetti et al. have pointed out that it is equivalent to an Ising model with a Hamiltonian that effectively counts the number of edge rule violations. Therefore, finding the assignment of factions that minimizes energy of the equivalent Ising system yields an estimate of the imbalance in the network. Based on the Ising model equivalence of the signed-social network balance problem, we have used the D-Wave 2X quantum annealing computer to explore some aspects of signed social networks. Because connectivity in the D-Wave computer is limited to its particular native topology, arbitrary networks cannot be represented directly. Rather, they must be “embedded” using a technique in which multiple qubits are chained together with special weights to

  6. Geophysic data interperetation of Passo della Morte landslide: Eastern Italian Alps

    Science.gov (United States)

    Zoppe', G.; Costa, G.; Marcato, G.; Forte, E.

    2012-04-01

    seismic site effects and the directivity in seismic site response of the rock mass have been investigated through the use of Nakamura (1989) method. In particular have been estimated the resonance frequencies and the polarization directions of seismic energy in three selected sites. All sites have shown a clear evidence of polarization in the direction of N/NW-S/SE and E/NE-W/SW, compatible with the maximum slope inclination and with the limestone stratification direction outcropping in this area. In order to define the stratigraphic and geological characteristics of the materials involved, have been performed a GPR investigation and an active seismic survey. The first has been useful to identify vertical and horizontal variations of the lithotypes present, most associated with different degrees of rock fracturing and fluid content. The seismic investigation has permitted to identify a reflective layer and to determine the propagation velocity of compression and shear waves of the two layers found.

  7. The influence of population on the economic efficiency of the metropolitan governance

    Directory of Open Access Journals (Sweden)

    Yuriy V. Pavlov

    2017-01-01

    Full Text Available Research purpose. In order to implement the optimal metropolitan governance model, it is important to understand the conditions under which this or that model is economically effective. There is a need to develop a quantitatively justified methodology for choosing the optimal metropolitan governance model for different types of metropolitan areas. It has been emphasized in some federal documents of Russia, for example, in the “Recommendations for the selection of pilot projects for approbation and improvement of mechanisms for managing the development of metropolitan areas in the Russian Federation”.Materials and methods. Domestic researchers (N. Zubarevich, K. Gonchar, etc. and foreign researchers (Glaeser Edward L., Nakamura, Ciccone A., Hall R., etc. carried out the study of quantitative relationships between the economic growth of cities and the characteristics of cities.However, for metropolitan areas, the analysis of the relationship has not yet been implemented between the outpacing economic growth of the metropolitan area relative to the average country values (labor productivity and GDP per capita, the institutional factor (the type of metropolitan governance model, andthe non-institutional factor (population size. To identify the dependencies we are interested in, we used the OECD statistical database and OECD researches to identify the metropolitan governance model in the sample of metropolitan areas in the world. The sample in this research was 87 metropolitan areas in Europe and was divided into groups, depending on the population and the introduced metropolitan governance model. For each group, a correlation-regression analysis was performed and a weighted average was calculated from the indexes of the economic growth. As the leading index of the economic growth, labor productivity was used, as the final - GDP per capita. Then a comparison was made between the real value of economic growth in each surveyed metropolitan area and

  8. EDITORIAL: LED light sources (light for the future) LED light sources (light for the future)

    Science.gov (United States)

    Grandjean, N.

    2010-09-01

    Generating white light from electricity with maximum efficacy has been a long quest since the first incandescent lamp was invented by Edison at the end of the 19th century. Nowadays, semiconductors are making reality the holy grail of converting electrons into photons with 100% efficiency and with colours that can be mixed for white light illumination. The revolution in solid-state lighting (SSL) dates to 1994 when Nakamura reported the first high-brightness blue LED based on GaN semiconductors. Then, white light was produced by simply combining a blue dye with a yellow phosphor. After more than a decade of intensive research the performance of white LEDs is quite impressive, beating by far the luminous efficacy of compact fluorescent lamps. We are likely close to replacing our current lighting devices by SSL lamps. However, there are still technological and fabrication cost issues that could delay large market penetration of white LEDs. Interestingly, SSL may create novel ways of using light that could potentially limit electricity saving. Whatever the impact of SSL, it will be significant on our daily life. The purpose of this special cluster issue is to produce a snapshot of the current situation of SSL from different viewing angles. In an introductory paper, Tsao and co-workers from Sandia National Laboratories, present an energy-economics perspective of SSL considering societal changes and SSL technology evolution. In a second article, Narukawa et al working at Nichia Corporation—the pioneer and still the leading company in SSL—describe the state of the art of current research products. They demonstrate record performance with white LEDs exhibiting luminous efficacy of 183 lm W-1 at high-current injection. Then, a series of topical papers discuss in detail various aspects of the physics and technology of white LEDs Carrier localization in InGaN quantum wells has been considered the key to white LEDs' success despite the huge density of defects. A

  9. High-Efficiency Nitride-Based Solid-State Lighting

    Energy Technology Data Exchange (ETDEWEB)

    Paul T. Fini; Shuji Nakamura

    2005-07-30

    In this final technical progress report we summarize research accomplished during Department of Energy contract DE-FC26-01NT41203, entitled ''High-Efficiency Nitride-Based Solid-State Lighting''. Two teams, from the University of California at Santa Barbara (Principle Investigator: Dr. Shuji Nakamura) and the Lighting Research Center at Rensselaer Polytechnic Institute (led by Dr. N. Narendran), pursued the goals of this contract from thin film growth, characterization, and packaging/luminaire design standpoints. The UCSB team initially pursued the development of blue gallium nitride (GaN)-based vertical-cavity surface-emitting lasers, as well as ultraviolet GaN-based light emitting diodes (LEDs). In Year 2, the emphasis shifted to resonant-cavity light emitting diodes, also known as micro-cavity LEDs when extremely thin device cavities are fabricated. These devices have very directional emission and higher light extraction efficiency than conventional LEDs. Via the optimization of thin-film growth and refinement of device processing, we decreased the total cavity thickness to less than 1 {micro}m, such that micro-cavity effects were clearly observed and a light extraction efficiency of over 10% was reached. We also began the development of photonic crystals for increased light extraction, in particular for so-called ''guided modes'' which would otherwise propagate laterally in the device and be re-absorbed. Finally, we pursued the growth of smooth, high-quality nonpolar a-plane and m-plane GaN films, as well as blue light emitting diodes on these novel films. Initial nonpolar LEDs showed the expected behavior of negligible peak wavelength shift with increasing drive current. M-plane LEDs in particular show promise, as unpackaged devices had unsaturated optical output power of {approx} 3 mW at 200 mA drive current. The LRC's tasks were aimed at developing the subcomponents necessary for packaging UCSB's light

  10. Analysis of the Moonquakes Database

    Science.gov (United States)

    Nefedyev, Yuri; Varaksina, Natalia; Zabbarova, Regina

    As know the moonquakes, discovered during the Apollo landing missions in the late 1960s to early 1970s, occur in isolated nests at depths about halfway to the center of the Moon. In spite of some previous efforts however, what causes them and what they tell us about the deep interior of the Moon remain as open questions (Y.Nakamura, 2007). In this report we set a target to compare physical basis earthquakes and moonquakes in order to use new methods of analysis developed for earthquakes. The discussion about the connection of poles motion and uneven rotation with seismic carried on actively in 60-70s of the last century (Yatskiv J.S., Mironov N.T., Korsun A.A. and Tarada V.K. Poles motion and uneven rotation of the Earth “Astronomy” (“Science and Technology Results”) 1976, 12, (pt. 1,2) ). As a rule, the earthquakes impact on the pole motion was under review, in particular, the issue of the seismic excitation of Chandler polar motion. The strongest earthquakes can cause the Earth’s crust movement indeed, reallocate oceanic mass can change the rotation axis position within the Earth. The conflicting results were obtained the conclusion was drawn that the accuracy of the observations were insufficient for solving this problem. Since then, the accuracy of observations has increased significantly, two strong earthquakes were in 2003-2004 years, in Gorny Altai (September 27, 2003) and near the Sumatra island (December 25, 2004). The magnitude of both earthquakes reached 9. The first of them was extraordinary in spite of being almost unnoticed because of under-populated district. The shocks of similar to such power can be with a frequency of once in 150 years, according to the Geophysics Institute of the Siberian RAS Branch data. The second was disastrous and led to many victims in Southeast Astra. This is the fifth powerful earthquake, which was recorded on the Earth since 1990, and the most strong after the natural calamity, which had been in Alaska in 1964

  11. Using sparse photometric data sets for asteroid lightcurve studies

    Science.gov (United States)

    Warner, Brian D.; Harris, Alan W.

    2011-12-01

    With the advent of wide-field imagers, it has become possible to conduct a photometric lightcurve survey of many asteroids simultaneously, either for that single purpose (e.g., Dermawan, B., Nakamura, T., Yoshida, F. [2011]. Publ. Astron. Soc. Japan 63, S555-S576; Masiero, J., Jedicke, R., Ďurech, J., Gwyn, S., Denneau, L., Larsen, J. [2009]. Icarus 204, 145-171), or as a part of a multipurpose survey (e.g., Pan-STARRS, LSST). Such surveys promise to yield photometric data for many thousands of asteroids, but these data sets will be “sparse” compared to most of those taken in a “targeted” mode directed to one asteroid at a time. We consider the potential limitations of sparse data sets using different sampling rates with respect to specific research questions that might be addressed with lightcurve data. For our study we created synthetic sparse data sets similar to those from wide-field surveys by generating more than 380,000 individual lightcurves that were combined into more than 47,000 composite lightcurves. The variables in generating the data included the number of observations per night, number of nights, noise, and the intervals between observations and nights, in addition to periods ranging from 0.1 to 400 h and amplitudes ranging from 0.1 to 2.0 mag. A Fourier analysis pipeline was used to find the period for each composite lightcurve and then review the derived period and period spectrum to gauge how well an automated analysis of sparse data sets would perform in finding the true period. For this part of the analysis, a normally distributed noise level of 0.03 mag was added to the data, regardless of amplitude, thus simulating a relatively high SNR for the observations. For the second part of the analysis, a smaller set of composite curves was generated with fixed core parameters of eight observations per night, 8 nights within a 14-day span, periods ranging from 2 to 6 h, and an amplitude of either 0.3 mag or 0.4 mag. Individual data sets using

  12. EDITORIAL: Enhance your outlook with Compound Semiconductor

    Science.gov (United States)

    Bedrock, Claire

    2007-12-01

    An overwhelming proportion of the articles published in this journal come under the heading of applied research. In this field research findings impact tomorrow's products, and so it's important to keep tabs on these developments. Grant applications, for example, can carry extra weight when the potential benefits to industry are outlined alongside the gains to fundamental science. What's more, it's just plain interesting to track how key breakthroughs in understanding can drive improvements in commercial devices. Within our publication group we offer free resources that can help you keep pace with trends in part of this sector. Compound Semiconductor magazine and its associated website, compoundsemiconductor.net, cover III-V, III-N, SiC and SiGe research in academia and industry, alongside all the business news and key manufacturing technology. A high proportion of our authoritative and timely content is exclusive, and you can access it for free by completing a simple registration procedure at compoundsemiconductor.net. Three examples of feature articles published this year in Compound Semiconductor include: • Non-polar GaN reaches tipping point by Steven DenBaars, Shuji Nakamura and Jim Speck from the University of California, Santa Barbara. Although conventional GaN LEDs are a great commercial success, they suffer from an intrinsic weakness—internal electric fields that pull apart the electrons and holes and ultimately limit efficiency. However, this problem can be overcome by growing nitrides on alternate crystal planes. Although early attempts were unsuccessful, due to high defect densities in the epilayers, this is not the case with growth on the latest Mitsubishi substrates that can lead to external quantum efficiencies of 45%. In this article the authors describe the development of their non-polar material, and their promising results for LEDs and laser diodes. • Inverting the triple junction improves efficiency and flexibility by Paul Sharps and

  13. Estimates of geodynamic state and structure of the local crust on the base of microseismic noise analysis

    Science.gov (United States)

    Loktev, D.; Spivak, A.

    2013-05-01

    A method for obtaining estimates of geodynamic state of the local crust and rock masses on the base of microseismic noise analysis is discussed. Microseismic noise is considered as a superposition of background microvibrations and a discrete component in the form of weak microseismic pulses generated by relaxational processes in the medium [1]. Currently active tectonic faults can be identified as zones with clustered sources of microseismic pulses and more intense amplitude variations of background microvibrations in tidal waves and baric variations in the atmosphere [2,3]. The presence of underground nonheterogeneities (i.e. contrasts in mechanic properties) and their scales are obtained from analysis of spectral characteristics of microseismic noise [4]. In the epicentral zone of an underground inhomogeneity we evidence characteristic quasi-chromatic pulses, stronger spectral density of local noise at high frequencies (more than 10 Hz) as well as maximum of spatial distribution of horizontal to vertical component spectral noise ratio (Nakamura parameter). The size of structural elements (blocks) of the Earth's crust is estimated by peak frequencies of momochromatic components of the spectrum on the base of the elaborated analytical model [1]. Parameters of weak pulses generated by relaxation (such as max velocity of oscillations, dominating (observed) period, etc.) yield estimates of differential movements of structural blocks in the medium as well as max stresses in the latter [5,6]. Examples are given to illustrate application of the proposed method to locating and mapping fault zones and underground nonheterogeneities in the Earth's crust, as well as to estimating scales of active structural blocks and their mobility potential when assessing places for nuclear atomic plants and underground nuclear waste storages. The method has also been successfully used for ranging hillsides of South Alps in terms of their liability to landslides. [1]. A.A. Spivak, S

  14. Synthesis, Properties and Structure of a Novel Unsymmetrical Bis (phenoxo) Bridged Binuclear Copper (

    Institute of Scientific and Technical Information of China (English)

    LU; Tong-bu

    2001-01-01

    [1]Koga T. , Furutachi H. , Nakamura T. , et al. , Inorg. Chem. , 37, 989(1998)[2]Koolhaas G. J. A. A. , Driessen W.L. , Reedijk J. , et al. , J. Chem. Soc. , Chem. Commun., 5. 517(1995)[3]Collinson S. R. , Fenton D. E. , Coord. Chem. Rev. , 148, 19(1996)[4]Coughlin P. K. , Dewan J. C. , Lippard S. J. , et al. , J. Am. Chem. Soc. , 101, 265(1979)[5]Drew M. G. B., McCann M., Nelson S. M., J. Chem. Soc., Dalton Trans., 9, 1 868(1981),[6]Drew M. G. B. , J. Chem. Soc. , Chem. Commun. , 7, 1 122(1980)[7]Pierre J. -L. , Chautemps P. , Refaif S. , et al. , J. Am. Chem. Soc. , 117, 1 965(1995)[8]Mao Z. W., Chen M. Q., Tan X. S., et al., Inorg. Chem., 34, 2 889(1995)[9]Lu Q. , Luo Q. H., Dai A. B., J. Chem. Soc., Chem. Commun., 4, 1 429(1990)[10]Okawa H. , Nishio J. , Ohba M. , et al. , Inorg. Chem., 32, 2 949(1993)[11]Yonemura M. , Matsumuro Y. , Furutachi H. , et al. , Inorg. Chem. , 36, 2 711(1997)[12]Furutachi H. , Okawa H. , Inorg. Chem. , 36, 3 911(1997)[13]Karunakaran S. , Kandaswamy M. , J. Chem. Soc. , Dalton Trans. , 10, 1 595(1994)[14]Marappan M., Narayanan V. , Kandaswamy M. , J. Chem. Soc. , Dalton Trans. , 20, 3 405(1998)[15]Sheldrick G. M. SHELXTL (Revision 5.03), System of Computer Programs for X-ray Structure Determination,University of Cambridge, 1993[16]Hong S. H., Applications of Spectra Methods in Organic Chemistry[M], Science Press, Beijing, 56(1980)[17]Lu T. B. , Gan X. M. , Tang N. , et al. , Chemical Research in Chinese Universities, 9, 319(1992)[18]Gan X. M. , Liang Z.J., Lu T. B. , et al. , Chemical Research in Chinese Universities, 12(4), 332(1996)[19]Lu T. B. , Li X, Y. , Mao Z. W. , et al. , Polyhedron, 17, 75(1998)[20]Yokoi H. , Sai M. , Isobe T. , et al. , Bull. Chem. Soc. Jpn. , 45, 2 189(1972)[21]Simmons C. J., Lundeen M. , Seff K. , Inorg. Chem. , 17, 1 429(1978)[22]Dehand J. , Jordanow J. , Keck F. , et al. , Inorg. Chem. , 18, 1 543(1979)[23

  15. Meteoritic and Geologic Context of the Chelyabinsk Near-Earth Asteroid Air Burst (Invited)

    Science.gov (United States)

    Kring, D. A.; Swindle, T. D.; Zolensky, M. E.

    2013-12-01

    LL-type material, similar to that re-covered from the 540-m-long Itokawa asteroid [6]. Both of those NEA were derived from one or more parent bodies >100 km diameter(s). Over 5,000 samples from an LL-chondrite parent body(ies) exist. Collisional events at 4.35-3.9 Ga are well-documented and several younger events have been suggested [7]. Whether one of those events or a separate event is responsible for the impact melt in Chelyabinsk is, as yet, unclear, but Ar-Ar analyses of the clasts and melt within Chelyabinsk are underway. References: [1] Grieve R. A. F. and Kring D. A. 2007. Comet/Asteroid Impacts & Human Society, pp. 3-24. [2] http://neo.jpl.nasa.gov/news/fireball_130301.html. [3] Consolmagno G. J. et al. 2008. Chemie der Erde 68:1-29. [4] Fuji-wara A. et al. 2006. Science 312:1330-1334. [5] Kring D. A. et al. 1996. Journal of Geophysical Research 101:29353-29371. [6] Nakamura T. et al. 2011. Science 333:1113-1116. [7] Swindle T. D. et al. 2013. In 40Ar/39Ar Dating: from Geochronology to Thermochronology, Archaeology to Planetary Science, in press.

  16. The human apoE7 and apoE4 transgenic mice models

    Institute of Scientific and Technical Information of China (English)

    SUN; Mingzeng; (

    2001-01-01

    [1]Weisgraber, K. H., Apolipoprotein E: Structure-function relationships, Adv. Pro. Chem., 1994, 45: 249-302.[2]Center, G. F., Paoletti, E. G., Apolipoprotein function in health and disease: Insights from natural mutations, Europ. J. Clin. Invest., 1996, 26: 733-746.[3]Browner, J. D., van Dormal, J. J., Muskiet, A. J., Clinical chemistry of common apolipoproteins, J. Chromat. B, 1996, 678: 623-641.[4]Maeda, H., Nakamura, H., Shozo, K. et al., Identification of human apolipoprotein E variant gene: Apolipoprotein E7 (Glu244, 245 Lys244, 245), J. Biochm., 1989, 105: 51-54.[5]Taylor, J. M., Downstream regulatory elements stimulate expression of the human plipoprotein E gene in the liver and suppress expression in the kidney of transgenic mice, Transassoc. Am. Physicians, 1990, 103: 119-128.[6]Smith, J. D., Plump, A. S., Breslow, J. L. et al., Accumulation of human apolipoprotein E in the plasma of transgenic mice, J. Biol. Chem., 1990, 265(25): 14709-14712.[7]Tazio, S., Lee, Y. L., Ji, Z. S. et al., Type III hyperlipoproteinemic phenotype in transgenic mice expressing dysfunctional apolipoprotein E, J. Clin. Invest., 1993, 92(3): 1497-1503.[8]Arn, M. J., Maagdenberg, M., Hofker, M. N. et al., Transgenic mice carrying the apolipoprotein E3-Leiden gene exhibit hyperlipoproteinemia, The J. Biol. Chem., 1993, 268(14): 10540-10545.[9]Qi, Z. H., Ru, K., Sun, M. Z. et al., The gene expression of pME in mouse NIH/3T3 cells and construction of the h-apoE transgenic mice, Chinese Biochem. J., 1997, 13(1): 24-28.[10]Sambrook, J., Fritsch, E. F., Maniatis, T., Molecular Cloning, A Laboratory Manual, New York: CSH Press, 1989, 81.[11]Hogan, B. L., Manipulation the mouse embryo, A Laboratory Manual, New York: CSH Press, 1989, 89.[12]Wandell, M. R., Rall, S. C., Brennan, S. Jr et al., Apolipoprotein E2-Dunedin (228 Arg-Cys): Anapolipoprotein E2 variant with normal receptor-binding activity, J. Lip. Res., 1990, 31: 534-543.[13

  17. Evaluation of effects of fenestrating decompression of jaw cysts in teenagers%青少年颌骨囊肿开窗减压术的疗效观察

    Institute of Scientific and Technical Information of China (English)

    徐文华; 程继光; 王元银; 王银龙

    2014-01-01

    目的:评价开窗减压术治疗青少年牙源性颌骨囊肿的疗效。方法30例9~18岁的青少年颌骨囊肿病例,行开窗减压术,每日行囊腔冲洗。于术后1、3、6个月复诊,行曲面断层片检查,观察和分析囊肿的长径变化、囊肿周围骨质骨化过程及囊腔内牙胚萌出情况,并参照Nakamura的疗效评价标准对治疗效果进行评价。结果术后1、3和6个月,囊腔逐渐被新生骨替代,颌骨生长发育及牙胚的萌出未受影响。疗效评价显示3个时间组整体或两两比较,均有显著性差异。术后6个月观察,19例(63.3%)颌骨囊肿行开窗减压术后疗效评价为优,9例(30%)评价为良,2例(6.7%)评价为疗效差,总有效率为93.3%。随访至术后1年时,18例患者囊腔消失,无需进一步治疗,12例患者在囊腔缩小的基础上继行囊肿刮治术,无1例复发。结论开窗减压术是治疗青少年颌骨囊肿的是一项安全、有效、适合推广的技术方法。%Objective To evaluate curative effect of fenestrating decompression on jaw cyst in teenagers .Methods Thirty cases were treated with fenestrating decompression and followed up by 1 month,3 months and 6 months after operation .Clinical symptoms and ra-diographical findings were analyzed according to Nakamura's method.Results The cysts cavity had been gradually replaced by the new born bones .The growth of jaw and eruption of dental germ were uninfluenced .There was significant difference between every two groups.Six months after operation, the effect of fenestrating decompression was evaluated as extremely effective (63.3%), moderately effective (30%), and poorly effective (6.7%).And the total effective rate was 93.3%.One year's follow up showed that the cystic lesions disappeared in 18 cases and enucleation was taken in the other 12 cases while the cavity became narrow and small .There was no recurrence.Conclusions The

  18. PREFACE: 15th International Conference on the Physics of Highly Charged Ions

    Science.gov (United States)

    Zou, Yaming; Hutton, Roger

    2011-07-01

    , under the Chairmanship of Professors Thomas Stoehlker and Joachim Ullrich. We wish them all the best with their plans and look forward to meeting you all again in 2012. Committees, Exhibitors and Sponsors HCI2010 International Advisory Committee F Aumayr (Austria) T Azuma (Japan) P Beiersdorfer (USA) J Burgdoerfer (Austria) A Cassimi (France) H Cederquist (Sweden) J Costello (Ireland) F Currell (UK) R Hoekstra (Holland) X Ma (China) F Martín (Spain) A Mueller (German) N Nakamura (Japan) M Pajek (Poland) R Rivarola (Argentina) Z Rudzikas (Lithuania) V Shabaev (Russia) R Schuch (Sweden) T Stoehlker (Germany) J Tanis (USA) L Tribedi (India) K Tokési (Hungary) J Ullrich (Germany) D Vernhet (France) Y Zou (China) T Zouros (Greece) HCI2010 Local Organizing Committee Co-chairs: Yaming Zou and Roger Hutton (Fudan university) Secretaries: Baoren Wei and Yunqing Fu (Fudan University) Treasurers: Xiuqing Xu and Daoli Xu (Shanghai Nuclear Society) Members Chongyang Chen (Shanghai) Jianmin Yuan (Changsha) Jun Yan (Beijing) Chenzhong Dong (Lanzhou) Xiaohong Cai (Lanzhou) Xinwen Ma (Lanzhou) Xuru Duan (Sichuan) Baohan Zhang (Sichuan) Exhibitors Andor Technology andor.com Shanghai Kelin Technology Development Co. Ltd chnkelin.com Varian Inc. varianinc.com Sponsors Natural Science Foundation of China International Union of Pure and Applied Physics (IUPAP) Fudan University

  19. Space weathering of asteroids: Lessons from Itokawa for future observations

    Science.gov (United States)

    Sasaki, Sho; HIroi, Takahiro

    2016-07-01

    -phase deposition processes on the optical, chemical, and magnetic properties of the lunar regolith, Moon, 13 (1975), 339-353 2) Keller L. P. and McKay D. S.: Science, 261 (1993), 1305-1307. 3) Pieters C. M., et al. Meteorit.: Planet. Sci., 35 (2000), 1101-1107. 4) Yamada, M., et al.: Earth Planets Space 51 (1999), 1255-1265. 5) Sasaki, S., et al.: Nature 410 (2001), 555-557. 6) Brunetto, R., et al.: Icarus 180 (1995), 546-554. 10) Brunetto, R., Loeffler, M. J., Nesvorny, D., Sasaki, S., and Strazzulla, G.: Asteroid Surface Alteration by Space Weathering Processes, in Asteroid IV, Univ. Arizona Press (2015). 11) Hirata, N., et al.: Icarus 200 (2009), 486-502. 12) Ishiguro, M.: Scattered light correction of Hayabusa/AMICA data and quantitative spectral comparisons of Itokawa, Pub. Astron. Soc. Japan, 66 (2014), 55 13) Noguchi, T., et al.: Icarus 206 (2010), 319-326. 14) Nakamura, T., et al.: Science 333 (2011), 1113-1116. 15] Tsuchiyama, A., et al.: Science 333 (2011), 1125-1128. [6) Noguchi, T., et al.: Science 333 (2011), 1121-1125. 17) Noguchi, T., et al.: Meteorit. Planet. Sci., 49 (2014), 188-214. 18) Matsumoto, T. et al. Icarus (2015) 257, 230. 19) Noble S. K. et al. (2011) Meteorit. Planet. Sci., 45 (2011), 2007.

  20. PREFACE: 14th International Conference on the Physics of Highly Charged Ions (HCI 2008)

    Science.gov (United States)

    Azuma, Toshiyuki; Nakamura, Nobuyuki; Yamada, Chikashi

    2009-07-01

    Physics of Highly Charged Ions will be held in Shanghai under the organization of Professor Y Zou of Fudan University and her colleagues. We wish the organizers of HCI2010 all possible success and are looking forward to meeting you all in Shanghai. Toshiyuki Azuma, Nobuyuki Nakamura and Chikashi Yamada Editors

  1. 带肝中静脉的活体右半肝移植供者Ⅳ段肝静脉分型对术后残肝淤血和再生的影响%The effect of segment Ⅳ hepatic vein's anatomy on remnant liver congestion and regeneration in right lobe liver graft donors with inclusion of the MHV

    Institute of Scientific and Technical Information of China (English)

    蒋文涛; 马楠; 王洪海; 张骊; 郭庆军; 潘澄; 邓永林; 郑虹; 朱志军

    2013-01-01

    Objective To investigate the effect of segment Ⅳ hepatic vein's type on the early remnant liver congestion and regeneration in right lobe living-related liver graft donors (LDLT) with the inclusion of middle hepatic vein (MHV).Methods Between October 2008 and April 2010,44 LDLT with MHV were performed.According to the type of Nakamura,we classified the segment Ⅳ hepatic vein by means of IQQA-MSCT and verified in operartion.We measured the volume of remnant liver by means of IQQA-MSCT and judged the congestion of segment Ⅳ through postoperative CT scan.Results IQQAMSCT was an effective method to construct and sort segment Ⅳ hepatic vein,which was verified by operartion.The ratio of serious segment Ⅳ congestion was 3.8% in type Ⅰ,40.0% in type Ⅱ,37.5% in type Ⅲ,and the difference was significant (x2 =9.004,P =0.007).Two weeks post operation,the volume of segments Ⅰ-Ⅲ in type Ⅰ was smaller than in type Ⅱ (F =7.977,P =0.01) and type Ⅲ (F =7.977,P =0.032),the volume of segment Ⅳ in type Ⅰ was bigger than in type Ⅱ (F =6.541,P =0.005) and type Ⅲ (F =6.541,P =0.014) conversely.The regeneration rate of segment Ⅳ in type Ⅰ was bigger than in type Ⅱ (F =4.14,P =0.027) and type Ⅲ (F =4.14,P =0.04),on the contrary,the regeneration rate of segments Ⅰ-Ⅲ in type Ⅰ was smaller than in in type Ⅱ (F =5.577,P =0.005) and type Ⅲ (F =5.577,P =0.047).But the regeneration rate of remnant liver was not different between the three groups (F =1.831,P =0.173).Conclusions IQQA-MSCT was an effective method to evaluate the donor in LDLT.The type of segment Ⅳ hepatic vein affected the remnant liver's congestion and regeneration.The segment Ⅳ hepatic vein's anatomy was significantly related with the postoperative congestion and regeneration of the remnant liver,which was compensated by the regeneration of segments Ⅰ-Ⅲ.%目的 了解带肝中静脉活体右半肝移植供者Ⅳ段肝静脉分型对术后残肝淤血

  2. La pesquería de tiburones oceánicos-costeros en los litorales de Colima, Jalisco y Michoacán

    Directory of Open Access Journals (Sweden)

    Angélica Cruz

    2011-06-01

    Full Text Available La pesquería de tiburón es una de las más importantes en el Pacífico mexicano, en la actualidad no se cuentan con los datos de la composición específica de las capturas de las diferentes flotas. En el presente trabajo se describen aspectos biológicos-pesqueros de las especies de tiburón, capturadas por la flota palangrera de mediana altura del puerto de Manzanillo, en un periodo anual de abril 2006-abril 2007, los muestreos se realizaron mensualmente a bordo de estas embarcaciones. La composición de las capturas estuvo representada por nueve especies (n=1 962, de las cuales Carcharhinus falciformis (Bibron, 1839 (88.12% sostiene esta pesquería y en segundo lugar Prionace glauca (Linnaeus, 1758 (8.21%. Las especies poco frecuentes fueron Sphyrna zygaena (Linnaeus, 1758 con (1.78%, Alopias pelagicus (Nakamura, 1935 (0.82%, Carcharhinus longimanus (Poey, 1861 (0.45%, Alopias superciliosus (Lowe, 1839 (0.35%, Carcharhinus leucas (Valenciennes, 1839 (0.1%, Carcharhinus limbatus (Valenciennes, 1839 (0.1% é Isurus oxyrinchus (Rafinesque, 1810 (0.05%. La fecundidad estimada para C. falciformis fue de 3-7 crías/hembra con tallas de 30-45cm LT; 40.57+2.03cm LT y P. glauca con 5-52 crías/hembra, con tallas de 5-18.6cm LT; 11.61±0.21cm LT. Por lo tanto se asume que C. falciformis presenta un ciclo concurrente y P. glauca probablemente un ciclo bianual consecutivo.Fishery of oceanic and coastal sharks in Colima, Jalisco and Michoacán. Shark fishery is one of the most important activities in the Mexican Pacific coast, nevertheless, there is few data available about the specific captures done by the fleet along the coast. This study describes fishery biology aspects of the shark species catched by the semi-industrial long-line fleet of Manzanillo. Monthly samplings were made on board of these vessels during an annual period from April 2006 to April 2007. Captured species composition (n=1 962 organisms was represented by nine species. The one

  3. Effects of Piracetam on Pediatric Breath Holding Spells: A Randomized Double Blind Controlled Trial

    Directory of Open Access Journals (Sweden)

    Ali ABBASKHANIAN

    2013-01-01

    events in children and adolescents. Pediatrics. 2002 Oct:110(4:e46. Kolkiran A, Tutar E, Atalay S, Deda G, Cin S. Autonomic nervous system functions in children with breath-holding spells and effects of iron deficiency. Acta Pediatric. 2005 Sep;94(9:1227-31.Hüdaoglu O, Dirik E, Yiş U, et al. Parental attitude of mothers, iron deficiency anemia, and breath-holding spells. Pediatr Neurol. 2006:Jul;35(1:18-20.Ahmad Bhat M, Ali W, Mohidin K, Sultana M. Prospective study of severe breath holding spells and role of iron. J Pediatr Neurol. 2007;5(1:27-32.Lombroso CT, Lerman P. Breath holding spells (cyanotic and pallid infantile syncope. Pediatrics. 1967 Apr;39(4:563-81.Gouliaev AH, Senning A. Piracetam and other structurally related nootropics. Brain Res Rev. 1994 May;19(20:180-222.Azam M, Bhatti N, Shahab N. Piracetam in severe breath holding spells. Int J Pschyiatry Med. 2008;38(2:195-201.Garg RK. Piracetam  for the treatment of breath holding spells. Indian Pediatrics.1998 Oct;35(10:1034-5.Donma MM. Clinical efficacy of piracetam in treatment of breath holding spells. Pediatr Neurol. 1998 Jan;18(1:41-5.Murata R, Matsuoka O, Hattori H, Kawawaki H, Nakajima S, Nakamura M et al. Efficacy of Kan-baku-taiso-to (TJ-72 on breath-holding spells in children. Am J Chin Med. 1988;16(3-4:155-8.Kelly AM, Porter CJ, Mc Goon MD, Espinosa RE, Osborn MJ, Hayes DL. Breath-holding spells associated with significant bradycardia: successful treatment with permanent pacemaker implantation. Pediatrics. 2001 Sep;108(3:698-702.McWilliam RC, Stephenson JB. Atropine treatment of reflex anoxic seizures. Arch Dis Child. 1984 May;59(5:473-5.Ashrafi MR, Mohammadi M, Shervin Badve R.        Efficacy of piracetam in treatment of breath-holding spells Iran J Pediatr. 2002;12(4:33-6.Daoud AS, Batieha A, al-Sheyyab M, Abuekteish F, Hijazi S. Effectiveness of iron therapy on breath-holding spells. J Pediatr. 1997 Apr;130(4:547-50.Ziaullah Nawaz S, Shah S, Talaat A. Iron deficiency anemia as a cause

  4. The Best Time for EEG Recording in Febrile Seizure

    Directory of Open Access Journals (Sweden)

    Parvaneh KARIMZADEH

    2014-01-01

    seizures. Arch Pediatr Adolesc Med 1997;151(4:371-8.Nelson KB, Ellenberg JH. Predictors of epilepsy in children who have experienced febrile seizures. N Engl J Med 1976;295(19:1029-33.Anonymous. Practice parameter: the neurodiagnostic evaluation of the child with a first simple febrile seizure. American Academy of Pediatrics. Provisional Committee on Quality Improvement, Subcommittee on Febrile Seizures. Pediatrics 1996;97(5:769-72; discussion:773-5.Rosman NP. Evaluation of the child who convulses with fever. Paediatr Drugs 2003;5(7:457-61.Kanemura H, Mizorogi S, Aoyagi K, Sugita K, Aihara M. EEG characteristics predict subsequent epilepsy in children with febrile seizure. Brain Dev 2012;34(4:302-7.Yamatogi Y, Ohtahara S. EEG in febrile convulsions. Am J EEG Techno1 1990;30:267-80.Aicardi J, Chevrie JJ. The significance of electroencephalographic paroxysms in children less than 3 years of age. Epilepsia 1973;14(1:47-55.Tsuboi T. Seizures of childhood: a population-based and clinic based study. Acta Neurol Scand Suppl 1986;110:1-237.Maytal J, Steele R, Eviatar L, Novak G. The value of early postictal EEG in children with complex febrile seizures. Epilepsia 2000;41(2:219-21.Joshi C, Wawrykow T, Patrick J, Prasad A. Do clinical variables predict an abnormal EEG in patients with complex febrile seizures? Seizure 2005;14(6:429-34.Lennox-Buchthal M. Febrile convulsions: a reappraisal. Electroencephalogr Clin Neurophysiol 1973;32:Suppl:1-138.Frantzen E, Lennox-Buchtal MA, Nygraad A. Longitudinal EEG and clinical study of children with febrile convulsions. Electroencephalogr Clin Neurophysiol 1968;24(3:197-212.Kajitani T, Ueoka K, Nakamura M, Kumanomidou Y. Febrile convulsions and rolandic discharges. Brain Dev 1981;3(4:351-9.Sofijanov N, Emoto S, Kuturec M, Dukovski M, Duma F, Ellenberg JH, et al. Febrile seizures: clinical characteristics and initial EEG. Epilepsia 1992;33(1:52-7.

  5. Generation of high reactive fluids by rapid clinopyroxene-seawater interaction: An experimental study at 425 °C, 40 and 100 MPa

    Science.gov (United States)

    Beermann, Oliver; Garbe-Schönberg, Dieter; Schächinger, Steffen; Arzi, Lisa; Holzheid, Astrid

    2014-05-01

    experiments significant amounts (~10-20 rel. %) of secondary mineral phases, i.e. talc, the serpentine-group minerals lizardite, antigorite, and chrysotile, and minor abundances of pyrrhotite and pentlandite were formed primarily on Cpx even after short run durations of 3 hours. Our results show that intense leaching of Ca, REEs, transition and trace metals only occurred with Cpx and only in the seawater experiments. Leaching was caused by rapid precipitation of the intitial seawater Mg (1400 ppm) on Cpx, which generated HCl(aq) with pH (25 °C) hydrothermalism, as it is evident from MAR 5° S fluids. This kind of hydrothermalism is expected to be not uncommon in particular at the slow-spreading MAR [9], and the high element fluxes here, most probably caused by seawater-pyroxene interactions, should be taken into account when modelling global chemical fluxes of MOR hydrothermalism. References: [1] German C. R., Thurnherr A. M., Knoery J., Charlou J.-L., Jean-Babtiste P., and Edmonds H. N. (2010) Deep Sea Res. 157, 518-527. [2] Schmidt K., Garbe-Schönberg D., Bau M., and Koschinsky A. (2010) Geochim. Cosmochim. Acta 74, 4058-4077. [3] Saito M. A., Noble A. E., Tagliabue A., Goepfert T. G., Lamborg C. H., and Jenkins W. J. (2013) Nat. Geosci. 5, 775-779. [4] German C. R., Bennett S. A., Connelly D. P., Evans A. J., Murton B. J., Parson L. M., Prien R. D., Ramirez-Llodra E., Jakuba M., Shank T. M., Yoerger D. R., Baker E. T., Walker S. L., and Nakamura K. (2008) Earth. Planet. Sci. Lett. 273, 332-344. [5] Haase K. M., Petersen S., Koschinsky A., and M64/1, M68/1 Scient. Parties (2007) Geochem. Geophys. Geosyst. 8, Q11002, doi: 10.1029/2006GC001509. [6] Koschinsky A., Garbe-Schönberg D., Sander S., Schmidt K., Gennerich H. H., and Strauss H. (2008) Geology 36, 615-618. [7] Elderfield H. and Schultz A. (1996) Annu. Rev. Earth Planet. Sci., 24, 191-224. [8] German C. R., Thurnherr A. M., Knoery J., Charlou J.-L., Jean-Baptiste P., and Edmonds H. N. (2010) Deep Sea Res. 157, 518

  6. PREFACE: Progress in the ITER Physics Basis

    Science.gov (United States)

    Ikeda, K.

    2007-06-01

    fundamental to its completion. I am pleased to witness the extensive collaborations, the excellent working relationships and the free exchange of views that have been developed among scientists working on magnetic fusion, and I would particularly like to acknowledge the importance which they assign to ITER in their research. This close collaboration and the spirit of free discussion will be essential to the success of ITER. Finally, the PIPB identifies issues which remain in the projection of burning plasma performance to the ITER scale and in the control of burning plasmas. Continued R&D is therefore called for to reduce the uncertainties associated with these issues and to ensure the efficient operation and exploitation of ITER. It is important that the international fusion community maintains a high level of collaboration in the future to address these issues and to prepare the physics basis for ITER operation. ITPA Coordination Committee R. Stambaugh (Chair of ITPA CC, General Atomics, USA) D.J. Campbell (Previous Chair of ITPA CC, European Fusion Development Agreement—Close Support Unit, ITER Organization) M. Shimada (Co-Chair of ITPA CC, ITER Organization) R. Aymar (ITER International Team, CERN) V. Chuyanov (ITER Organization) J.H. Han (Korea Basic Science Institute, Korea) Y. Huo (Zengzhou University, China) Y.S. Hwang (Seoul National University, Korea) N. Ivanov (Kurchatov Institute, Russia) Y. Kamada (Japan Atomic Energy Agency, Naka, Japan) P.K. Kaw (Institute for Plasma Research, India) S. Konovalov (Kurchatov Institute, Russia) M. Kwon (National Fusion Research Center, Korea) J. Li (Academy of Science, Institute of Plasma Physics, China) S. Mirnov (TRINITI, Russia) Y. Nakamura (National Institute for Fusion Studies, Japan) H. Ninomiya (Japan Atomic Energy Agency, Naka, Japan) E. Oktay (Department of Energy, USA) J. Pamela (European Fusion Development Agreement—Close Support Unit) C. Pan (Southwestern Institute of Physics, China) F. Romanelli (Ente per le

  7. PREFACE: Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009) Selected contributions from the 3rd Theory Meets Industry International Workshop, TMI2009 (Nagoya, Japan, 11-13 November 2009)

    Science.gov (United States)

    Tanaka, Isao; Hafner, Jürgen; Wimmer, Erich; Asahi, Ryoji

    2010-09-01

    . Lectures and poster presentations were thus solicited from leading international academic and industrial researchers. The large audience that attended responded to the high quality of the talks with pertinent questions and lively discussions. The third workshop, TMI2009, was held over three days from 11-13 November, 2009, at the Nagoya International Center, Nagoya, Japan. Invited talks were given by 23 speakers from 9 countries from both the academic and industry sectors. The speakers were Ryoji Asahi (Toyota Central R&D Labs, Japan), Tomas Bucko (University of Vienna, Austria), Gábor Csányi (University of Cambridge, UK), Alessandro De Vita (King's College London, UK), Bernard Delley (Paul Scherrer Institute, Switzerland), Christophe Domain (EDF, France), George Fitzgerald (Accelrys, USA), Takeo Fujiwara (University of Tokyo, Japan), Jürgen Hafner (University of Vienna, Austria), Masaya Ishida (Sumitomo Chemicals, Japan), Werner Janse Van Rensburg (Sasol Technology, South Africa), Masanori Kohyama (AIST, Japan), Takao Kotani (Tottori University, Japan), Georg Kresse (University of Vienna, Austria), Katsuyuki Matsunaga (Kyoto University, Japan), Stefan Müller (University of Erlangen-Nuremberg, Germany), Shin-ichiro Nakamura (Mitsubishi Chemicals, Japan), Fumiyasu Oba (Kyoto University, Japan), Tamio Oguchi (Hiroshima University, Japan), Pascal Raybaud (IFP, France), Isao Tanaka (Kyoto University/JFCC, Japan), Göran Wahnström (Chalmers University of Technology, Sweden), and Erich Wimmer (Materials Design Inc., USA). There were 40 poster presentations in total. The workshop was attended by approximately 120 participants with approximately 50 per cent from industry. The invited talks covered advances in ab initio solid-state calculations and their practical use in industry. Presentations outlining the progress made in treating large and complex systems, as well as more accurate and efficient calculation methods, were given from the theory side. Examples of the use of ab

  8. Chiral Dynamics 2006

    Science.gov (United States)

    Ahmed, Mohammad W.; Gao, Haiyan; Weller, Henry R.; Holstein, Barry

    2007-10-01

    of singular potentials and power counting / M.P. Valderrrama. The challenge of calculating Baryon-Baryon scattering from lattice QCD / S.R. Beane. Precise absolute np scattering cross section and the charged [Pie symbol] NN coupling constant / S. E. Vigdor. Probing hadronic parity violation using few nucleon systems / S.A. Page. Extracting the neutron-neutron scattering length from neutron-deuteron breakup / C.R. Howell. Extraction of [equationl] from [Pie symbol]-d --> [equation] / A. Grudestig. The three- and four-body system with large scattering length / L. Platter. 3N and 4N systems and the Ay puzzle / T. Clegg. Recent progress in nuclear lattice simulations with effective field theory / D. Lee. Few-body studies at KVI / J.G. Messchendorp. Results of three nucleon experiments from RIKEN / K. Sekiguchi. A new opportunity to measure the total photoabsorption cross section of helium / P. T. Debevec. Three-body photodisintegration of 3He with double polarizations / X. Zong. Large two-pion exchange contributions to the pp --> pp[Pie symbol]0 reaction / F. Myhrer. Towards a systematic theory of nuclear forces / E. Epelbaum. Ab initio calculations of eletromagnetic reactions in light nuclei / W. Leidemann. Electron scattering from a polarized deuterium target at BLAST / R. Fatemi. Neutron-neutron scattering length from the reaction [equation] / V. Lensky. Renormalization group analysis of nuclear current operators / S.X. Nakamura. Recent results and future plans at MAX-LAB / K.G. Fissum. Nucleon polarizabilities from deutron compton scattering, and its lessons for chiral power counting / H. W. Grie hammer. Compton scattering on HE-3 / D. Choudhury -- pt. D. Hadron structure and Meson-Baryon interactions. Summary of the working group on Hadron structure and Meson-Baryon interactions / G. Feldman and T.R. Hemmert. Finite volume effects: lattice meets CHPT / G. Schierholz. Lattice discretization errors in chiral effective field theories / B.C. Tiburzi. SU(3)-breaking

  9. PREFACE: Dynamics of low-dimensional systems Dynamics of low-dimensional systems

    Science.gov (United States)

    Bernasconi, M.; Miret-Artés, S.; Toennies, J. P.

    2012-03-01

    Chulkov Surface phonons on Pb(111) I Yu Sklyadneva, R Heid, K-P Bohnen, P M Echenique and E V Chulkov Using evidence from nanocavities to assess the vibrational properties of external surfaces G F Cerofolini, F Corni, S Frabboni, G Ottaviani, E Romano, R Tonini and D Narducci Magnetic properties and relaxation dynamics of a frustrated Ni7 molecular nanomagnet E Garlatti, S Carretta, M Affronte, E C Sañudo, G Amoretti and P Santini A theoretical study of rotational and translational diffusion dynamics of molecules with a six-fold point symmetry adsorbed on a hexagonal lattice by neutron scattering I Calvo-Almazán, S Miret-Artés and P Fouquet Vibrational dynamics and surface structure of Bi(111) from helium atom scattering measurements M Mayrhofer-Reinhartshuber, A Tamtögl, P Kraus, K H Rieder and W E Ernst Double and triple ionization of silver clusters by electron impactAvik Halder, Anthony Liang, Chunrong Yin and Vitaly V Kresin Scattering of O2 from a graphite surface W W Hayes, Junepyo Oh, Takahiro Kondo, Keitaro Arakawa, Yoshihiko Saito, Junji Nakamura and J R Manson Zero-phonon lines of systems with different dimensions and unconventional vibronic interactions V Hizhnyakov A kinetic Monte Carlo approach to investigate antibiotic translocation through bacterial porins Matteo Ceccarelli, Attilio V Vargiu and Paolo Ruggerone Quantum Zeno and anti-Zeno effects in surface diffusion of interacting adsorbates H C Peñate-Rodrìguez, R Martìnez-Casado, G Rojas-Lorenzo, A S Sanz and S Miret-Artés Weakly bound finite systems: (4He)N-Rb2(3Σu), clustering structures from a quantum Monte Carlo approach D López-Durán, R Rodrìguez-Cantano, T González-Lezana, G Delgado-Barrio, P Villarreal, E Yurtsever and F A Gianturco Multiphonon atom-surface scattering from corrugated surfaces: derivation of the inelastic scattering spectrum for diffraction statesBranko Gumhalter Probing the non-pairwise interactions between CO molecules moving on a Cu(111) surfacePepijn R Kole, Holly

  10. REPORT FROM THE ORGANIZERS: The 25th International Conference on Low Temperature Physics

    Science.gov (United States)

    Kes, Peter

    2009-03-01

    recipients of the most important prize in low temperature physics, the Fritz London Memorial Prize 2008, were Yuriy M Bunkov (Institute Neël, Grenoble), Vladimir V Dmitriev, and Igor A Fomin (both Kapitza Institute, Moscow). They got the prize for their discovery and understanding of the 'Phase Coherent Spin Precession and Spin Superfluidity of 3He-B'. The Simon Prize 2008 of The Physical Society went to Yasunobu Nakamura and Jaw-Shen Tsai (NEC Laboratories, Tsukuba) for their 'Pioneering demonstration of quantum coherent behaviour in a macroscopic object and for their subsequent explorations of quantum coherent physics in a series of novel superconducting devices'. The Nicholas Kurti European Science Prize (sponsored by Oxford Instruments) was awarded to Lieven Vandersypen (Delft University of Technology) for his 'Ground-breaking work on the coherent control of nuclear and electron spins, with possible application to quantum information processing'. Finally, the first IUPAP Young Scientist Prizes in Low Temperature Physics went to Kostya Novoselov (University of Manchester) for his 'Contribution in the discovery of graphene and for pioneering studies of its extraordinary properties', to Dai Aoki (Tohuko University, Sendai) for his 'Discovery of novel heavy fermion superconductivity in actinide compounds', and to Viktor Tsepelin (Lancaster University) for 'The development of new experimental techniques and key discoveries in the fields of 3He crystals and quantum turbulence'. All prize recipients got the opportunity to present their work in an invited oral contribution. As is common practice nowadays all announcements, registrations, paper submissions and communications regarding program and practical matters were done electronically, either by email or via internet. Nevertheless, the program book was still printed and handed out to all participants at registration and they received an electronic version on a USB stick as well. The stick also contained all the submitted

  11. Report from the organizers Report from the organizers

    Science.gov (United States)

    Kes, Peter

    2009-04-01

    conferences time is reserved for prize ceremonies. The recipients of the most important prize in low temperature physics, the Fritz London Memorial Prize 2008, were Yuriy M Bunkov (Institute Néel, Grenoble), Vladimir V Dmitriev, and Igor A Fomin (both Kapitza Institute, Moscow). They got the prize for their discovery and understanding of the 'phase coherent spin precession and spin superfluidity of 3He-B'. The Simon Prize 2008 of The Physical Society went to Yasunobu Nakamura and Jaw-Shen Tsai (NEC Laboratories, Tsukuba) for their 'pioneering demonstration of quantum coherent behaviour in a macroscopic object and for their subsequent explorations of quantum coherent physics in a series of novel superconducting devices'. The Nicholas Kurti European Science Prize (sponsored by Oxford Instruments) was awarded to Lieven Vandersypen (Delft University of Technology) for his 'ground-breaking work on the coherent control of nuclear and electron spins, with possible application to quantum information processing'. Finally, the first IUPAP Young Scientist Prizes in Low Temperature Physics went to Kostya Novoselov (University of Manchester) for his 'contribution in the discovery of graphene and for pioneering studies of its extraordinary properties', to Dai Aoki (Tohuko University, Sendai) for his 'discovery of novel heavy fermion superconductivity in actinide compounds', and to Viktor Tsepelin (Lancaster University) for 'the development of new experimental techniques and key discoveries in the fields of 3He crystals and quantum turbulence'. All prize recipients got the opportunity to present their work in an invited oral contribution. As is common practice nowadays all announcements, registrations, paper submissions and communications regarding program and practical matters were done electronically, either by email or via the internet. Nevertheless, the program book was still printed and handed out to all participants at registration and they received an electronic version on a USB

  12. PREFACE: International Conference on Inverse Problems 2010

    Science.gov (United States)

    Hon, Yiu-Chung; Ling, Leevan

    2011-03-01

    Sciences, South KoreaYu Jiang, Hokkaido University, JapanDe-Xing Kong, Zhejiang University, ChinaOlga Krivorotko, Novosibirsk State University, RussiaPhilipp Küegler, Austrian Academy of Sciences, AustriaKiwoon Kwon, Dongguk University, South KoreaChun-Kong Law, National Sun Yat-sen University, TaiwanJune-Yub Lee, Ewha Womans University, South KoreaMing Li, City University of Hong Kong, HKSARMikyoung Lim, Korea Advanced Institute of Science and Technology (KAIST), South KoreaJijun Liu, Southeast University, ChinaXiaodong Liu, Chinese Academy of Sciences, ChinaFuming Ma, Jilin University, ChinaHang Ma, Shanghai University, ChinaValdemar Melicher, Ghent University, BelgiumGen Nakamura, Hokkaido University, JapanLong Tuan Nguyen, Ruhr-Universitat Bochum, GermanyEtibar Panakhov, Firat University, TurkeyRobert Plato, University of Siegen, GermanyJean-Pierre Puel, The University of Tokyo, JapanHans-Jürgen Reinhardt, University of Siegen, GermanyMaxim Shishlenin, Sobolev Institute of Mathematics, RussiaIlya Silvestrov, Institute of Petroleum Geology and Geophysics SB RAS, RussiaMourad Sini, Austrian Academy of Sciences, AustriaJán Sládek, Slovak Academy of Sciences, SlovakiaZhijun Tan, Sun Yat-sen University, ChinaQuan-Fang Wang, The Chinese University of Hong Kong, HKSARWenyan Wang, The University of Tokyo, JapanPihua Wen, Queen Mary, University of London, UKZhihai Xiang, Tsinghua University, ChinaXiang-Tuan Xiong, Northwest Normal University, ChinaDinghua Xu, Zhejiang Sci-Tech University, ChinaYongzhi Steve Xu, University of Louisville, USAJiaqing Yang, Chinese Academy of Sciences, ChinaJian Zhang, Sichuan Normal University, ChinaYing Zhang, Fudan University, ChinaTing Zhou, University of Washington, USAJianxin Zhu, Zhejiang University, China Advisory BoardH Thomas Banks, North Carolina State University, USATony F Chan, The Hong Kong University of Science and Technology, HKSARHeinz W Engl, Johannes Kepler Universitát Linz, AustriaRainer Kress, Georg-August-Universitát G

  13. EDITORIAL: From reciprocal space to real space in surface science From reciprocal space to real space in surface science

    Science.gov (United States)

    Bartels, Ludwig; Ernst, Karl-Heinz

    2012-09-01

    Triest.let's finish—aus basta Some move atoms around to hear how they sound.Karl-Heinz Rieder, Erice, 6 April 1998 From reciprocal space to real space in surface science contents From reciprocal space to real space in surface scienceLudwig Bartels and Karl-Heinz Ernst Karl-Heinz Reider: the quiet pioneerGiorgio Benedek Scattering of CO and N2 molecules by a graphite surfaceJunepyo Oh, Takahiro Kondo, Keitaro Arakawa, Yoshihiko Saito, Junji Nakamura, W W Hayes and J R Manson Helium, neon and argon diffraction from Ru(0001)M Minniti, C Díaz, J L Fernández Cuñado, A Politano, D Maccariello, F Martín, D Farías and R Miranda Enhanced charge transfer in a monolayer of the organic charge transfer complex TTF-TNAP on Au(111)T R Umbach, I Fernandez-Torrente, J N Ladenthin, J I Pascual and K J Franke Extended pattern recognition scheme for self-learning kinetic Monte Carlo simulationsSyed Islamuddin Shah, Giridhar Nandipati, Abdelkader Kara and Talat S Rahman Acetylene on Cu(111): imaging a molecular surface arrangement with a constantly rearranging tipYeming Zhu, Jonathan Wyrick, Kamelia D Cohen, Katie Marie Magnone, Connor Holzke, Daniel Salib, Quan Ma, Dezheng Sun and Ludwig Bartels Coulomb attraction during the carpet growth mode of NaClFriederike Matthaei, Sarah Heidorn, Konrad Boom, Cord Bertram, Ali Safiei, Jörg Henzl and Karina Morgenstern Molecular self-assembly on an insulating surface: interplay between substrate templating and intermolecular interactionsMarkus Kittelmann, Philipp Rahe and Angelika Kühnle Vertical manipulation of native adatoms on the InAs(111)A surfaceJ Yang, C Nacci, J Martínez-Blanco, K Kanisawa and S Fölsch Charge transfer between isomer domains on n+-doped Si(111)-2 × 1: energetic stabilizationR M Feenstra, G Bussetti, B Bonanni, A Violante, C Goletti, P Chiaradia, M G Betti and C Mariani Probing the properties of metal-oxide interfaces: silica films on Mo and Ru supportsLeonid Lichtenstein, Markus Heyde, Stefan Ulrich, Niklas Nilius

  14. Transmission eigenvalues

    Science.gov (United States)

    Cakoni, Fioralba; Haddar, Houssem

    2013-10-01

    iterative least square method to identify the spherically stratified index of refraction from transmission eigenvalues. On the characterization of transmission eigenvalues in terms of far-field measurements, a promising new result is obtained by Kirsch and Lechleiter [21] showing how one can identify the transmission eigenvalues using the eigenvalues of the scattering operator which are available in terms of measured scattering data. In the paper by Kleefeld [22], an accurate method for computing transmission eigenvalues based on a surface integral formulation of the interior transmission problem and numerical methods for nonlinear eigenvalue problems is proposed and numerically validated for the scalar problem in three dimensions. On the other hand, the paper by Sun and Xu [23] investigates the computation of transmission eigenvalues for Maxwell's equations using a standard iterative method associated with a variational formulation of the interior transmission problem with an emphasis on the effect of anisotropy on transmission eigenvalues. From the perspective of using transmission eigenvalues in non-destructive testing, the paper by Cakoni and Moskow [24] investigates the asymptotic behavior of transmission eigenvalues with respect to small inhomogeneities. The paper by Nakamura and Wang [25] investigates the linear sampling method for the time dependent heat equation and analyses the interior transmission problem associated with this equation. Finally, in the paper by Finch and Hickmann [26], the spectrum of the interior transmission problem is related to the unique determination of the acoustic properties of a body in thermoacoustic imaging. We hope that this collection of papers will stimulate further research in the rapidly growing area of transmission eigenvalues and inverse scattering theory.

  15. Geochemical study of boron isotopes in the process of loess weathering

    Institute of Scientific and Technical Information of China (English)

    ZHAO; Zhiqi; (

    2003-01-01

    ., Atmospheric carbon dioxide concentrations over the past 60 million years, Nature, 2000, 406: 695-699.[25]Liu Tungsheng, Loess and Environment (in Chinese), Beijing: Science Press, 1985, 191-302.[26]Gu Zhaoyan, Lal, D., Guo Zhengtang et al., 10Be geochemical characteristics of loess and redclay on the Loess Plateau, Quaternary Research (in Chinese), 2000, 20(5): 409-423.[27]Liu Tungsheng, Loess and Environment (in Chinese), Bejing: Science Pres, 1985, 1-481.[28]Zhao Zhiqi, Liu Congqiang, Xiao Yinkai, Separation of boron in acid-soluble phases in loess and paleosol deposits and its isotopic determination, Geochimica (in Chinese), 2000, 29(4): 351-357.[29]Xiao, Y. K., Beary, E. S., Fassett, J. D., An improved method for the high-precision isotopic measurement of boron by thermal ionization masses spectrometry, Int'l. J. Mass Spect. and Ion Proc., 1988, 85: 203-213.[30]Spivack, A. J., Edmond, J. M., Determination of boron isotope ratios by thermal ionization mass spectrometry of the dicesium metaborate cation, Anal. Chem., 1986, 58: 31-35.[31]Kiss, E., Ion-exchange separation and spectrophotometric determination of boron in geological materials, Anal. Chem. Acta, 1988, 211: 243-256.[32]Liu Tungsheng, Loess and Environment (in Chinese), Beijing: Science Press, 1985, 44-106.[33]Liu Congqiang, Zhao Zhiqi, Xiao Yinkai, Boron isotopic composition of loess and its implication for climatic tracing, Quaternary Research (in Chinese), 2000, 20(4): 394.[34]Taylor, S. R., Mclennan, S. M., Mcculloch, M. T., Geochemistry of loess, continental crustal composition and crustal model age, Geochim. Cosmochim. Acta, 1983, 47: 1897-1905.[35]Liu, C. Q., Masuda, A., Okada, A. et al., A geochemical study of loess and desert sand in northern China: Implications for continental crust weathering and composition, Chemical Geology, 1996, 106: 359-374.[36]Ishikawa, T., Nakamura, E., Boron isotope systematics of marine sediment, Earth Planet Sci. Lett., 1993, 117

  16. REE and

    Institute of Scientific and Technical Information of China (English)

    LIU; Jihua

    2005-01-01

    elements in the sedimentary cycle: A summary, Chemistry Geology, 1974, 14: 285-304.[13]Piper, D. Z., Rare earth elements in ferromanganese nodules and other marine phase, Geochim. Cosmochim. Acta, 1974, 38: 1007-1023.[14]Fleet, A. J., Aqueous and sedimentary geochemistry of rare earth elements, in Rare Earth Elements Geochemistry (ed. Henderson, P.), Amsterdam: Elsevier, 1984, 343-421.[15]Faure, G., Principles of Isotope Geology, New York: John Wiley & Sons, 1986, 117-248.[16]Tlig, S., Steinberg, M., Distribution of rare earth elements (REE) in size fractions of recent sediments of the Indian Ocean, Chemical Geology, 1982, 37: 317-333.[17]Toyoda, K., Nakamura, Y., Masuda, A., Rare earth elements of Pacific pelagic sediments, Geochim. Cosmochim. Acta, 1990, 54: 1093-1103.[18]Liu Jihua, Liang Hongfeng, Xia Ning et al., REE geochemistry of fractions less than 2 μm in pelagic sediments from the eastern Pacific, Geochimica (in Chinese), 1998, 27(1): 49-58.[19]Goldstein, S., O'Nions, R. K., Nd and Sr isotopic relationships in pelagic clay and ferromanganese deposits, Nature, 1981, 292: 324-327.[20]Jones, C. E., Halliday, A. N., Rea D. K. et al., Neodymium isotopic variations in North Pacific modern silicate sediment and the insignificance of detrital REE contributions to seawater, Earth Planet Sci. Lett., 1994, 127: 55-66.[21]Dean, W. E., Leinen, M., Stow, D. A. V., Classification of deep-sea fine-grained sediments, Journal of Sedimentary Petrology, 1985, 55: 250-256.[22]Biscaye, P. E., Mineralogy and sedimentation of recent deep-sea clay in the Atlantic Ocean and adjacent seas and oceans, Geological Society of American Bulletin, 1965, 76: 803-832.[23]Wang Zhonggang, Yu Xueyuan, Zhao Zhenhua et al., Rare Earth Element Geochemistry (in Chinese), Beijing: Science Press, 1989, 88-93.[24]Haskin, L. A., Haskin, M. A., Frey, F. A. et al., Relative and absolute terrestrial abundances of the rare earths, in: Origin and Distribution of

  17. PREFACE: Rutherford Centennial Conference on Nuclear Physics

    Science.gov (United States)

    Freeman, Sean

    2012-09-01

    Dobacewski (Warsaw, Poland) G Dracoulis (ANU, Australia) S J Freedman (LBL, USA) M Hass (Weizmann Institute, Israel) M Huyse (Leuven, Belgium) P Jones (Birmingham, UK) D Khao (Hanoi, Vietnam) R Krücken (Munich, Germany) K Langanke (Darmstadt, Germany) C Lister (Argonne, USA) G A Miller (University of Washington, USA) D Morrissey (MSU, USA) T Motobayashi (RIKEN, Japan) S Nagamiya (J-PARC, Japan) W Nazarewicz (ORNL, USA) S Mullins (iThemba, South Africa) T Nakamura (Tokyo, Japan) P Roussel Chomaz (GANIL, France) R Ribas (Sao Paolo, Brazil) M Vanderhaeghen (Mainz, Germany) U Wiedner (Uppsala, Sweden) F Xu (Peking University, China) Q Zhao (IHEP, Bejing) W Zajc (Columbia, USA)

  18. PREFACE: Nanosafe2010: International Conference on Safe Production and Use of Nanomaterials

    Science.gov (United States)

    Sentein, Carole; Schuster, Frédéric; Tardif, François

    2011-07-01

    ESevertsov Inst. of Ecology and Evolution, RU KÜCK AUniv. Bremen, DE KUO Y-MChung Hwa University, TW KVITEK LPalacky Univ., CZ LABILLE JCEREGE, FR LAMMINEN EDekati, FI LARUE CCEA, FR LE BIHAN OINERIS, FR LE DUR DEcomesure, FR LECERF PCILAS, FR LEGRAND MCordouan, FR LELONG CUJF CEA, FR LIMOUSIN SINERIS, FR LINDELOEV JGEA Process Engineering, DK LIU P PChina Jiliang University, CN LIU WCEREGE, FR MACHEREY A-CCNRS, FR MAGGA YCEA, FR MAHLENDORF FUniversity Duisburg-Essen, DE MANIER NINERIS, FR MANZO LUniv. Pavia, IT MARCHETTO ACEA, FR MARCONE GUNICAMP, BR MARI DEPFL, CH MARIE-DESVERGNE CCEA, FR MARIE-LOUISE APSA Peugeot-Citroen, FR MARMUSE LNano-H S.A.S., FR MARRA JPhilips Research Aerasense, NL MASION ACEREGE, FR MATEI EPolitehnica University Bucharest, RO MATSUI YKyoto Univ., JP MATZKE MUniv. Gothenburg, SE MAYNE-L'HERMITE MCEA, FR MELINTE G ABabes-Bolyai University, RO MERINO CGrupo Antolin Ingenieria, ES MICHAUD-SORET ICEA, FR MICHELETTI CJRC, IT MONTIGEL EBasler Versicherungen, CH MONTOYA ERAMEM, ES MOSSUZ VCEA, FR MOTELLIER SCEA, FR MOTZKUS CLNE, FR MUIR BNaneum, GB NAKAMURA KJAPAN NUS CO., JP NEUBAUER NKarlsruhe Institute of Technologie, DE NEUMEISTER LBG ETEM, DE NGUYEN TNIST, US NIORT NINTERTEK, FR NOIRTIN AINTERTEK, FR NOWACK BEmpa, CH NYEMBE DUniv. Johannesburg, ZA Ó CLAONADH NDublin Institute of Technology, IE OBERDÖRSTER GUniv. Rochester, US OGURA IAIST, JP OSTIGUY CIRSST, CA OTSUKA KJFE Techno-Research Corp., JP OUF F-XIRSN, FR OUSACI SALMA, FR PAGET VCEA, FR PAILLEUX MEcole des Mines de Saint Etienne, FR PANDARD PINERIS, FR PANZER OEuropean Research Services, DE PARISELLI FCNRS, FR PERLET JNANO Magazine, GB PETERS RRIKILT, NL PETIT A-NCEA, FR PETKOVIC JNational Institute of Biology, SI PIMENOFF JBeneq, FI PINAULT MCEA, FR PIRET J-PUniv. Namur, BE PONTONE RTekna Plasma Systems, FR POURCHEZ JEcole des Mines de Saint Etienne, FR PRAETORIUS AETH Zurich, CH PRAT OCEA, FR PREVENSLIK TQED Radiations, CN PREVOST CIRSN, FR PROY HUART DFrance Nature Environnement, FR PUI

  19. Ejecta emplacement: from distal to proximal

    Science.gov (United States)

    Artemieva, N.

    2008-09-01

    ballistically and included rheologic models for Newtonian or Bingham materials based on observations (runout distance, height of the distal ridge). Our model establishes better initial conditions for ejecta flow formation and provide estimates for the properties of fluidized ejecta directly on the basis of the particles/gas ratio, particle size, and temperaturedensity conditions in the ejecta. Venus. Ejecta deposition on Venus is substantially non-ballistic due to thick Venusian atmosphere. Some of impact craters are surrounded by "dark halos" [26- 28], others have unique dark parabolas, representing surficial deposits of loose material lifted during crater formation [29-30]. Methods of two-phase hydrodynamics may be useful to describe mechanism of their formation. References [1] Dobrovolskis A. (1981) Icarus 47, 203-219. [2] Cintala M.J., et al. (1999) M&PS. 34, 605-623. [3] Oberbeck V.R. (1975) Rev. Geophys. Space Phys. 13, 337-362. [4] Dressler et al. (2004) M&PS 39, 857- 878. [5] Hörz F. et al. (1983) Rev Geophys.Space Phys. 21, 1667-1725. [6] Valentine G.A. and Wohletz K.H. (1989) JGR 94, 1867-1887. [7] Dobran F. and Neri A. (1993) JGR 98, 4231-4259. [8] Neri A. et al. (2003) JGR 108, doi:10.1029/ 2001JB000508. [9] Boothroyd R.G. (1971) Flowing gas-solids suspension, Chapman and Hall Ltd, London. [10] Shuvalov V.V. (1999) Shock waves 9, 381-390. [11] Nakamura A. and Fujiwara A. (1991) Icarus 92, 132- 146. [12] Grady D.E. and Kipp M.E. (1980) Int. J. Rock Mech. Min. Sci. Geomech. Abstr. 17, 147-157. [13] Melosh H.J. et al. (1992) JGR 97, 14735-14759. [14] Gault, D.E. et al. (1963) NASA TND-1767. [15] Vickery A.M. (1986) Icarus 67, 224-236. [16] Melosh H.J. (1984) Icarus 59, 234-260. [17] Shuvalov V.V. (2002) LPSC-33, abstr.#1259. [18] Stöffler et al. (2002) M&PS 37, 1893-1908. [19] Melosh H.J. and Artemieva N.A. (2004) LPSC-35, abstr. #1723. [20] Osinski et al. (2004) Meteoritics Planet. Sci. 39, 1655-1683. [21] Ivanov B.A. et al. (1997) LPSC 28, 637-638. [22] Garvin J

  20. PREFACE: XVth International Conference on Calorimetry in High Energy Physics (CALOR2012)

    Science.gov (United States)

    Akchurin, Nural

    2012-12-01

    /Saclay Irfu/SPP FRANCAVILLA, Paolo IFAE Barcelona GATAULLIN, Marat California Institute of Technology GATTO, Corrado INFN-Napoli GAUDIO, Gabriella INFN-Pavia GERMANI, Stefano INFN-Perugia Goldenzweig, Pablo University of Rochester GRAF, Norman SLAC National Accelerator Laboratory GROOM, Don Lawrence Berkeley Lab GUARDINCERRI, Elena Los Alamos National Laboratory HAUPTMAN, John Iowa State University HENRIQUES, Ana CERN HUANG, Jin Los Alamos National Laboratory HU, Tao IHEP-Beijing, CAS JIANG, Xiaodong Los Alamos National Laboratory JUI, Charles University of Utah KAPUSTINSKY, Jon Los Alamos National Laboratory KIBILKO, Mark SE Technical Sales, Inc. KIRSCHENMANN, Henning University of Hamburg KISTENEV, Edouard Brookhaven National Laboratory KLIMEK, Pawel Stockholm Universitet KROEGER, Robert University of Mississippi LECOQ, Paul CERN LEE, Sehwook Texas Tech University LEE, Sung-Won Texas Tech University LIVAN, Michele Pavia University LUTZ, Benjamin DESY MAGILL, Stephen Argonne National Laboratory MATHIS, Mark College of William and Mary MATTHEWS, John University of Utah MENKE, Sven Max-Planck-Institut fuer Physik MOULSON, Matthew INFN-Frascati NAGEL, Martin Max-Planck-Institut fuer Physik NAKAMURA, Isamu KEK NEMECEK, Stanislav FZU AVCR Praha NESSI-TEDALDI, Francesca ETH Zurich NOVOTNY, Rainer 2nd Physics Institute, University Giessen OREGLIA, Mark University of Chicago PERLOFF, Alexx Texas A&M University PETYT, David Rutherford Appleton Laboratory RAHMAT, Rahmat University of Mississippi RAMILLI, Marco Hamburg Universitaet ROSIER LEES, Sylvie LAPP- IN2P3-CNRS RUTHERFOORD, John University of Arizona SAKUMA, Tai Texas A&M University SANTIAGO CERQUEIRA, Augusto Federal University of Juiz de Fora SARRA, Ivano INFN-Frascati SEIDEL, Sally University of New Mexico SEIFERT, Frank TU Dresden, Germany SHAMIM, Mansoora University of Oregon SIMON, Frank Max-Planck-Institute for Physics STAFFAN, Paul Wiener Plein and Baus, Corp Dr. STAROVOITOV, Pavel DESY TABARELLI DE FATIS, Tommaso