WorldWideScience

Sample records for involves timely production

  1. All energy production involves danger

    International Nuclear Information System (INIS)

    Pleym, H.

    1976-01-01

    s pointed out that while the protective ozone layer in the upper atmosphere is threatened by supersonic air traffic and releases of freon, there is an increase in the concentration of ozone in the biosphere. The biological effect of ozone in forming free radicals is similar to the biological effect of ionising rad radiation, and the normal atmospheric concentration of ozone produces 3600 times the number of free radicals per person per year as does a background radiation of 100 mrem per year. It is also pointed out that the limits for sulphur oxides and nitrogen oxides in the atmosphere are 100 and 5 times the background levels respectively, while the limit for radioactive release is 1/100 th of the background level. The transmission of solar energy from space stations by microwave is also thought to be dubious due to possible biological effects of such radiation. In conclusion a balanced view on the biological and environmental hazards of power generation from all sources, and not only nuclear, is called for. (JIW)

  2. Top Management Involvement in New Product Development

    DEFF Research Database (Denmark)

    Felekoglu, Burcu; Maier, Anja; Moultrie, James

    2010-01-01

    a broader conceptual space than this participation. This paper reviews the literature on top management involvement in new product development (NPD) and discusses relevance of different theoretical perspectives from other disciplines such as management, organisational behaviour and communication to analyse......Involvement of top managers in new product development (NPD) is a critical factor affecting NPD performance and frequently considered to be the participation of top management to certain activities in NPD or their NPD related behaviours. However, “Top management involvement in NPD” occupies...... antecedents, realisation and consequences of top management involvement in NPD. It is argued that top management has different involvement at different NPD levels: organisation level and project level. Resulting from this literature review, a tentative framework for top management involvement in NPD...

  3. Managing supplier involvement in new product development: a portfolio approach

    NARCIS (Netherlands)

    Wynstra, Finn; ten Pierick, E.

    2000-01-01

    Supplier involvement in new product development projects has become an increasingly popular method for improving project effectiveness (product costs and quality) and project efficiency (development costs and time). One of the key issues in managing this involvement is determining which type of

  4. Real time production optimization

    Energy Technology Data Exchange (ETDEWEB)

    Saputelli, Luigi; Otavio, Joao; Araujo, Turiassu; Escorcia, Alvaro [Halliburton, Houston, TX (United States). Landmark Division

    2004-07-01

    Production optimization encompasses various activities of measuring, analyzing, modeling, prioritizing and implementing actions to enhance productivity of a field. We present a state-of-the-art framework for optimizing production on a continuous basis as new sensor data is acquired in real time. Permanently acquired data is modeled and analyzed in order to create predictive models. A model based control strategy is used to regulate well and field instrumentation. The optimum field operating point, which changes with time, satisfies the maximum economic return. This work is a starting point for further development in automatic, intelligent reservoir technologies which get the most out of the abilities of permanent, instrumented wells and remotely activated downhole completions. The strategy, tested with history-matched data from a compartmentalised giant field, proved to reduce operating costs while increasing oil recovery by 27% in this field. (author)

  5. Exploring purchasing involvement in product development

    NARCIS (Netherlands)

    Wynstra, J.Y.F.; Weggeman, M.C.D.P.; Weele, van A.J.

    2003-01-01

    With increasing outsourcing and the growing importance of product innovation as a means for creating competitive advantage, the integration of purchasing and product development processes has become a key issue for many firms. Although, consequently, the integration of purchasing and suppliers in

  6. Time management strategies for research productivity.

    Science.gov (United States)

    Chase, Jo-Ana D; Topp, Robert; Smith, Carol E; Cohen, Marlene Z; Fahrenwald, Nancy; Zerwic, Julie J; Benefield, Lazelle E; Anderson, Cindy M; Conn, Vicki S

    2013-02-01

    Researchers function in a complex environment and carry multiple role responsibilities. This environment is prone to various distractions that can derail productivity and decrease efficiency. Effective time management allows researchers to maintain focus on their work, contributing to research productivity. Thus, improving time management skills is essential to developing and sustaining a successful program of research. This article presents time management strategies addressing behaviors surrounding time assessment, planning, and monitoring. Herein, the Western Journal of Nursing Research editorial board recommends strategies to enhance time management, including setting realistic goals, prioritizing, and optimizing planning. Involving a team, problem-solving barriers, and early management of potential distractions can facilitate maintaining focus on a research program. Continually evaluating the effectiveness of time management strategies allows researchers to identify areas of improvement and recognize progress.

  7. Warped product space-times

    Science.gov (United States)

    An, Xinliang; Wong, Willie Wai Yeung

    2018-01-01

    Many classical results in relativity theory concerning spherically symmetric space-times have easy generalizations to warped product space-times, with a two-dimensional Lorentzian base and arbitrary dimensional Riemannian fibers. We first give a systematic presentation of the main geometric constructions, with emphasis on the Kodama vector field and the Hawking energy; the construction is signature independent. This leads to proofs of general Birkhoff-type theorems for warped product manifolds; our theorems in particular apply to situations where the warped product manifold is not necessarily Einstein, and thus can be applied to solutions with matter content in general relativity. Next we specialize to the Lorentzian case and study the propagation of null expansions under the assumption of the dominant energy condition. We prove several non-existence results relating to the Yamabe class of the fibers, in the spirit of the black-hole topology theorem of Hawking–Galloway–Schoen. Finally we discuss the effect of the warped product ansatz on matter models. In particular we construct several cosmological solutions to the Einstein–Euler equations whose spatial geometry is generally not isotropic.

  8. Real-time image fusion involving diagnostic ultrasound

    DEFF Research Database (Denmark)

    Ewertsen, Caroline; Săftoiu, Adrian; Gruionu, Lucian G

    2013-01-01

    The aim of our article is to give an overview of the current and future possibilities of real-time image fusion involving ultrasound. We present a review of the existing English-language peer-reviewed literature assessing this technique, which covers technical solutions (for ultrasound...

  9. User Involvement as a Configurable Integrated Product Delivery

    DEFF Research Database (Denmark)

    Vibæk, Kasper Sánchez

    2009-01-01

    as a configurable integrated product delivery then the architect can – using slightly provocatively a term from the production industry – be seen a configuration manager of processes shaping our physical surroundings. Products focusing on standardisation and mass customisation of the building process rather than......Integrated product deliveries as known from the product industry are beginning to emerge in construction. These are normally considered as physical systems that can be configured and customised for a specific delivery to form part of a unique construction project and help to reduce the complexity...... relevant field for development of customisable integrated product deliveries in construction. This development and its causes challenge the traditional role of the architect as the centre point in the creation of physical wholes or entireties. If user involvement, as argued, can be considered...

  10. What drives consumer involvement? The relative impact of product category and product attribute

    DEFF Research Database (Denmark)

    de Barcellos, Marcia Dutra; Kügler, Jens Oliver; Scholderer, Joachim

    2009-01-01

    , foods, household appliances, alcoholic beverages) and on two involvement dimensions (interest and importance). The results indicate that in three of the four super-categories the predominant source of variation in product involvement were the attributes of the products, not the product category...... they belong to. Only for foods, the traditional conceptualisation of involvement held. The findings suggest that parts of previous research on involvement may have to be re-interpreted and that future research should adopt more complex conceptualisations of involvement. From a managerial point of view...

  11. Consumers’ versatile buying behavior irrespective to high and low involvement products

    OpenAIRE

    Hasan, Syed Akif; Subhani, Muhammad Imtiaz; Osman, Ms. Amber

    2012-01-01

    The consumers of today are impulse and cautious buyers at the same time. This study basically comprehends the concept of non-linearity towards the consumer purchase behavior for either high or low involvement of products. The research was interesting to note the consumption patterns of different product classes. The peculiarity of this study found the same non-linearity wavelengths between the high and low involvement products’ that was shaped by the consumers buying intention and actions. AD...

  12. A model of the supplier involvement in the product innovation

    Directory of Open Access Journals (Sweden)

    Kumar Manoj

    2017-01-01

    Full Text Available In this paper we examine the product innovation in a supply chain by a supplier and derive a model for a supplier’s product innovation policy. The product innovation of a supplier can contribute to the long-term competitiveness for the supply chain, and as it is for many supply chains a major factor, it should be considered in the development of strategies for a supplier. Here, we evaluate the effectiveness of supplier product innovation as a strategic tool to enhance the competitiveness and viability of supply chain. This paper explores the dynamic research performance of a supplier with endogenous time preference under a given arrangement of product innovation. We find that the optimal effort level and the achieved product innovation obey a saddle point path, or show tremendous fluctuations even without introducing the stochastic nature of product innovative activity. We also find that the fluctuation frequency is largely dependent both on the supplier’s characteristics such as supplier’s product innovative ability and on the nature of product innovation process per se. Short-run analyses are also made on the effect of supply chain cooperation in the product innovation process.

  13. Collaborative innovation: Internal and external involvement in new product development

    DEFF Research Database (Denmark)

    Timenes Laugen, Bjørge; Lassen, Astrid Heidemann

    2011-01-01

    Industry and academia alike are increasingly becoming aware of the fact that innovation does not take place in isolated cells or functions within the firm. During the last the years the term open innovation has emphasized the importance of internal and external collaboration in order to increase...... strategic priorities influence the degree of external and internal involvement in the NPD process, moderated by contextual factors. Results based on analyses of 584 companies from the International Manufacturing Strategy Survey (IMSS) 2005 indicate that suppliers are heavily involved in the NPD process...... in firms in B2C markets aiming at increasing the innovation volume. For B2B companies the reverse picture emerges. However, when the aim is to increase the radicality of new products, suppliers and customers are heavily involved for firms in B2B markets. Further, market uncertainty, and to some extent...

  14. Participatory methods for initiating manufacturing employees' involvement in product innovation

    DEFF Research Database (Denmark)

    Jensen, Anna Rose Vagn; Jensen, Christian Schou; Broberg, Ole

    2016-01-01

    approach that we apply to two case companies, this paper presents an empirical study of how to initiate involvement of manufacturing employees in R&D activities. We have used participatory methods from design thinking that has the ability to create relations between employees from different backgrounds......Employee-driven innovation has the potential to improve product innovation by involving employees as innovative resources. However, it can be a challenge to turn the potential into a reality of collaboration practices across organizational structures and culture. Through an interactive research...... and through a series of facilitated workshops we have investigated how these methods can initiate employee involvement. We see that participatory methods can improve understanding and relation between R&D and manufacturing departments, and thereby support a creative collaboration and emergence of employee...

  15. The Timing Effects of Reward, Business Longevity, and Involvement on Consumers’ Responses to a Reward Program

    Directory of Open Access Journals (Sweden)

    Badri Munir Sukoco

    2015-06-01

    Full Text Available Managers could elicit customers’ repeat purchase behavior through a well-designed reward program. This study examines two extrinsic cues - business longevity and timing effects of reward – to determine the consumers’ perceived risk and intention to participate in this kind of program. Moreover, this study discusses how different levels of involvement might interact with these two cues. An experiment with a 2 (business longevity: long vs. short x 2 (timing of reward: delayed vs. immediate x 2 (involvement: high vs. low between-subject factorial design is conducted to validate the proposed research hypotheses. The results show that an immediate reward offered by an older, more established, firm for a highly-involved product, make loyalty programs less risky and consequently attract consumers to participate. Interestingly, immediate rewards that are offered by older firms for a product that customers are less involved in has the opposite effects. Managerial and academic implications are further presented in this study.

  16. Worker's perceptions of time, time-use-attitudes and productivity

    OpenAIRE

    E. Ben-Baruch; C. P. H. Myburgh; E. C. Anderssen

    1991-01-01

    Decreasing productivity and increasing wage demands are singled out as being crucial problems facing the economy of South Africa. Changes in the time perceptions and time-use-attitudes of workers could play a decisive role in increasing productivity. The relationships between time perception, needs, motivation and productivity are analysed. Culture, tradition, economy, and environment lend a specific significance to these variables. Workers in a technological society should be guided to adapt...

  17. Time-optimal control of infinite order distributed parabolic systems involving time lags

    Directory of Open Access Journals (Sweden)

    G.M. Bahaa

    2014-06-01

    Full Text Available A time-optimal control problem for linear infinite order distributed parabolic systems involving constant time lags appear both in the state equation and in the boundary condition is presented. Some particular properties of the optimal control are discussed.

  18. A comparative study of Swedish generation Y decision-making style between high involvement and low involvement products.

    OpenAIRE

    Pakdeejirakul, Warangkhana; Agosi, Micheal

    2013-01-01

    Title A comparative study of Swedish generation Y decision-making style between high involvement and low involvement products. Research questions  How does product involvement influence consumer decision-making styles in Generation Y of Swedish nationals for the two selected products?  To what level does the model proposed by Sproles and Kendall in 1986 now apply to the modern-day Generation Y in Sweden as they decide on both of the selected products? Purpose The purpose of this research unde...

  19. Benefits of mass customized products: moderating role of product involvement and fashion innovativeness.

    Science.gov (United States)

    Park, Minjung; Yoo, Jungmin

    2018-02-01

    The objective of this study was to explore impacts and benefits of mass customized products on emotional product attachment, favorable attitudes toward a mass customization program, and the ongoing effect on loyalty intentions. This study further investigated how benefits, attachment, attitudes, and loyalty intentions differed as a function of involvement and fashion innovativeness. 290 female online shoppers in South Korea participated in an online survey. Results of this study revealed that perceived benefits positively influenced emotional product attachment and attitudes toward a mass customization program. In addition, attachment positively influenced attitudes, which in turn affected loyalty intentions. This study also found that benefits, attachment, attitudes, and loyalty intentions were all higher in highly involved consumers (high fashion innovators) than those in less involved consumers (low fashion innovators). This study concludes with theoretical and practical implications for mass customization programs.

  20. Benefits of mass customized products: moderating role of product involvement and fashion innovativeness

    Directory of Open Access Journals (Sweden)

    Minjung Park

    2018-02-01

    Full Text Available The objective of this study was to explore impacts and benefits of mass customized products on emotional product attachment, favorable attitudes toward a mass customization program, and the ongoing effect on loyalty intentions. This study further investigated how benefits, attachment, attitudes, and loyalty intentions differed as a function of involvement and fashion innovativeness. 290 female online shoppers in South Korea participated in an online survey. Results of this study revealed that perceived benefits positively influenced emotional product attachment and attitudes toward a mass customization program. In addition, attachment positively influenced attitudes, which in turn affected loyalty intentions. This study also found that benefits, attachment, attitudes, and loyalty intentions were all higher in highly involved consumers (high fashion innovators than those in less involved consumers (low fashion innovators. This study concludes with theoretical and practical implications for mass customization programs.

  1. The Impacts of Country-of-origin, Product Involvement, and Product Familiarity on Product Evaluation

    OpenAIRE

    Nugroho, Sahid Susilo; Rostiani, Rokhima; Gitosudarmo, Indriyo

    2014-01-01

    One of the most interesting phenomena in global business is the existence of a product’scountry-of-origin (COO). COO as an informational cue has been proven to affect consumer’spurchasing decisions in terms of their perception towards the product’s attributes as well astheir overall evaluation of the product. The objective of this study is to investigate the impacts ofcountry-of-origin on product evaluation in the Indonesian market by considering consumers’product familiarity and consumers’ p...

  2. Issues Involved in Developing Ada Real-Time Systems

    Science.gov (United States)

    1989-02-15

    expensive modifications to the compiler or Ada runtime system to fit a particular application. Whether we can solve the problems of programming real - time systems in...lock in solutions to problems that are not yet well understood in standards as rigorous as the Ada language. Moreover, real - time systems typically have

  3. Consumer perceptions of food products involving genetic modification

    DEFF Research Database (Denmark)

    Grunert, Klaus G.; Lähteenmäki, L.; Nielsen, Niels Asger

    2001-01-01

    Product descriptions of cheese, candy and salmon products were presented to samples of respondents in four Nordic countries. The descriptions represented various applications of genetic modification (GM), varied along a "distance" dimension and a "what is modified" dimension, and were presented...... along with a conventionally produced product. Respondents ranked the products according to preference, and their perceptions were ascertained by the laddering method. Results indicate that respondents regard "non-GM" as a value in itself, and associate the use of GM with a host of negative consequences...... were product specific....

  4. Worker's perceptions of time, time-use-attitudes and productivity

    Directory of Open Access Journals (Sweden)

    E. Ben-Baruch

    1991-06-01

    Full Text Available Decreasing productivity and increasing wage demands are singled out as being crucial problems facing the economy of South Africa. Changes in the time perceptions and time-use-attitudes of workers could play a decisive role in increasing productivity. The relationships between time perception, needs, motivation and productivity are analysed. Culture, tradition, economy, and environment lend a specific significance to these variables. Workers in a technological society should be guided to adapt to and live by the value system needed to uphold productivity. Opsomming Voortdurende afnemende produktiwiteit teenoor looneise wat styg, is een van die kritieke probleme waarmee die Suid-Afrikaanse ekonomie gekonfronteer word. Die verandering van werkers se tydpersepsie en verandering van houdinge teenoor die benutting van tyd kan deurslaggewend in die verhoging van produktiwiteit wees. In die lig hiervan is die verwantskap tussen tydpersepsie, behoeftes, motivering en prodrktiwiteit ondersoek. In die ontleding word aandag geskenk aan die invloed wat kultuur, tradisie, ekonomie en die omgewing op hierdie veranderlikes het. Opieiding in 'n tegnologiese samelewmg behoort daarop gerig te wees om 'n waardesisteem by werkers te laat ontwikkel wat produktiwiteit kan bevorder.

  5. Time-ordered products and Schwinger functions

    International Nuclear Information System (INIS)

    Eckmann, J.P.; Epstein, H.

    1979-01-01

    It is shown that every system of time-ordered products for a local field theory determines a related system of Schwinger functions possessing an extended form of Osterwalder-Schrader positivity and that the converse is true provided certain growth conditions are satisfied. This is applied to the phi 3 4 theory and it is shown that the time-ordered functions and S-matrix elements admit the standard perturbation series as asymptotic expansions. (orig.) [de

  6. Early user involvement in designing intelligent products and environments

    NARCIS (Netherlands)

    Kuijt-Evers, L.; Steen, M.

    2008-01-01

    A literature review was conducted on user involvement in design. The focus of the review was on how researchers and designers attempt to cooperate with end-users, with the goal of making a better match with end-users’ needs and preferences. The main goal of the research was to get insight in which

  7. Pricing and Timing Strategies for New Product Using Agent-Based Simulation of Behavioural Consumers

    OpenAIRE

    Keeheon Lee; Hoyeop Lee; Chang Ouk Kim

    2014-01-01

    In this study, we are interested in the problem of determining the pricing and timing strategies of a new product by developing an agent-based product diffusion simulation. In the proposed simulation model, agents imitate behavioural consumers, who are reference dependent and risk averse in the evaluation of new products and whose interactions create word-of-mouth regarding new products. Pricing and timing strategies involve the timing of a new product release, the timing of providing a disco...

  8. Short time ahead wind power production forecast

    International Nuclear Information System (INIS)

    Sapronova, Alla; Meissner, Catherine; Mana, Matteo

    2016-01-01

    An accurate prediction of wind power output is crucial for efficient coordination of cooperative energy production from different sources. Long-time ahead prediction (from 6 to 24 hours) of wind power for onshore parks can be achieved by using a coupled model that would bridge the mesoscale weather prediction data and computational fluid dynamics. When a forecast for shorter time horizon (less than one hour ahead) is anticipated, an accuracy of a predictive model that utilizes hourly weather data is decreasing. That is because the higher frequency fluctuations of the wind speed are lost when data is averaged over an hour. Since the wind speed can vary up to 50% in magnitude over a period of 5 minutes, the higher frequency variations of wind speed and direction have to be taken into account for an accurate short-term ahead energy production forecast. In this work a new model for wind power production forecast 5- to 30-minutes ahead is presented. The model is based on machine learning techniques and categorization approach and using the historical park production time series and hourly numerical weather forecast. (paper)

  9. Short time ahead wind power production forecast

    Science.gov (United States)

    Sapronova, Alla; Meissner, Catherine; Mana, Matteo

    2016-09-01

    An accurate prediction of wind power output is crucial for efficient coordination of cooperative energy production from different sources. Long-time ahead prediction (from 6 to 24 hours) of wind power for onshore parks can be achieved by using a coupled model that would bridge the mesoscale weather prediction data and computational fluid dynamics. When a forecast for shorter time horizon (less than one hour ahead) is anticipated, an accuracy of a predictive model that utilizes hourly weather data is decreasing. That is because the higher frequency fluctuations of the wind speed are lost when data is averaged over an hour. Since the wind speed can vary up to 50% in magnitude over a period of 5 minutes, the higher frequency variations of wind speed and direction have to be taken into account for an accurate short-term ahead energy production forecast. In this work a new model for wind power production forecast 5- to 30-minutes ahead is presented. The model is based on machine learning techniques and categorization approach and using the historical park production time series and hourly numerical weather forecast.

  10. Farming Systems Involving Fruit Crops Production And Research In ...

    African Journals Online (AJOL)

    Research interventions to expand the scope of the farmers have shown that greater efficiency of land utilization is exhibited. New areas of research for the evaluation, as well as suggests consideration for intercropping with fruit trees are suggested. The current challenges to fruit production were also identified, while the ...

  11. Fission product retention during faults involving steam generator tube rupture

    International Nuclear Information System (INIS)

    Rodliffe, R.S.

    1983-08-01

    In some PWR fault conditions, such as stuck open safety relief valve in the secondary circuit or main steam line break, the release of fission products to the atmosphere may be increased by the leakage of primary coolant into the secondary circuit following steam generator tube rupture. The release may be reduced by retention either within the primary circuit or within the affected steam generator unit (SGU). The mechanisms leading to retention are reviewed and quantified where possible. The parameters on which any analysis will be most critically dependent are identified. Fission product iodine and caesium may be retained in the secondary side of a SGU either by partition to retained water or by droplet deposition on surfaces and subsequent evaporation to dryness. Two extreme simplifications are considered: SGU 'dry', i.e. the secondary side is steam filled, and SGU 'wet', i.e. the tube bundle is covered with water. Consideration is given to: the distribution of fission products between gaseous and aerosol forms; mechanisms for droplet formation, deposition and resuspension; fission product retention during droplet or film evaporation primary coolant mixing and droplet scrubbing in a wet SGU; and the performance of moisture separators and steam driers. (author)

  12. Agency and civic involvement in news production via Facebook commentary

    DEFF Research Database (Denmark)

    Eberholst, Mads Kæmsgaard; Hartley, Jannie Møller

    Social media services such as Facebook, Twitter and Youtube, where users create and share content, has become a large part of most peoples everyday digital life and equally media companies has realised that these services plays a great role in peoples news con-sumption pattern. On these services...... users can contribute to the publication process, in theory broadening the diversity of public debate. This paper explores user involvement on the Facebook pages of Danish mainstream online newspapers in November 2012 and investigate the hypothesises that user interactivity gives audiences greater power...

  13. Narrative transportation and product involvement : how narrativity factors are used to enchance transportive experience in advertising for high vs. low involvement products

    OpenAIRE

    Phusapan, Panida

    2013-01-01

    This paper examines and presents how narrativity factors are used to enhance consumers‟ transportive experience when advertising for high and low involvement products. It specifically looks at processing experiences among Thai online consumers when viewing TV commercials available on a YouTube channel. The paper brings the theory of product involvement into a field of narrative transportation. Results show that narrativity factors should be used with the right balance across all narrativity l...

  14. Production, staff, working time and financial planning

    Directory of Open Access Journals (Sweden)

    Orlando Boiteux

    2009-07-01

    Full Text Available Aggregate planning can be a tool for coordinating the tactical decisions belonging to some functional areas of a company. This potential has been limited due to methodological and technical reasons, but nowadays it is possible to solve very sophisticated models integrating, with a high level of detail, a great number of decisions of several functional areas and that permit to include new management schemes. In this paper, a production, staff, working time and cash management model is introduced.

  15. Molecular mechanisms involved in the production of chromosomal aberrations. I

    International Nuclear Information System (INIS)

    Natarajan, A.T.; Obe, G.

    1978-01-01

    Chinese hamster ovary cells (CHO) were X-irradiated in G2 stage of the cell cycle and immediately treated, in the presence of inactivated Sendai virus, with Neurospora endonuclease (E.C. 3.1.4.), an enzyme which is specific for cleaving single-stranded DNA. With this treatment, the frequencies of all types of chromosome aberrations increased when compared to X-irradiated controls. These results are interpreted as due to the conversion of some of the X-ray induced single-stranded DNA breaks into double-strand breaks by this enzyme. Similar enhancement due to this enzyme was found following treatment with methyl methanesulfonate (MMS) and bleomycin, but not following UV and mitomycin C. Addition of Micrococcus endonuclease and Neurospora endonuclease to the cells did not alter the frequencies of aberrations induced by UV. The introduction of enzymes with specific DNA-repair function offers possibilities to probe into the molecular events involved in the formation of structural chromosome aberrations induced by different classes of physical and chemical mutagens. (Auth.)

  16. Moderating Role of Product Involvement on the Relationship Between Brand Personality and Brand Loyalty

    OpenAIRE

    SUDDIN LADA; SAMSINAR MD. SIDIN; KENNY TEOH GUAN CHENG

    2014-01-01

    Drawing from observations by consumer behavior theorists and product involvement studies, the present study seeks to investigate the moderating role of product involvement on the relationship between brand personality and brand loyalty. A total of 958 respondents participated in this study. They completed a 14-items questionnaire to measure product involvement, and a 32-items and 16-items questionnaire to measure brand personality and brand loyalty respectively. Results suggest that the effec...

  17. The purchase decision process and involvement of the elderly regarding nonprescription products.

    Science.gov (United States)

    Reisenwitz, T H; Wimbish, G J

    1997-01-01

    The elderly or senior citizen is a large and growing market segment that purchases a disproportionate amount of health care products, particularly nonprescription products. This study attempts to examine the elderly's level of involvement (high versus low) and their purchase decision process regarding nonprescription or over-the-counter (OTC) products. Frequencies and percentages are calculated to indicate level of involvement as well as purchase decision behavior. Previous research is critiqued and managerial implications are discussed.

  18. Attitudinal and behavioral response to coo cues for low involvement product

    OpenAIRE

    Khalique, Muhammad; Chan, Angelina Wan Sian; de Run, Ernest Cyril

    2012-01-01

    A considerable number of empirical studies on country-of-origin had indicated its influence on consumer product evaluation as well as purchase intention. Previous research also suggests the outcomes of country-of-origin effect differ by product type investigated in addition to countries selected for examination. The main crux of this study to explore the role that country-of-origin cue plays on Malaysian consumer’s product evaluation as well as purchase intention of a low involvement product ...

  19. Factors influencing first-time fathers' involvement in their wives' pregnancy and childbirth: A correlational study.

    Science.gov (United States)

    Xue, Weilin Lynn; He, Hong-Gu; Chua, Ying Jie; Wang, Wenru; Shorey, Shefaly

    2018-03-20

    To examine factors influencing first-time fathers' involvement in their wives' pregnancy and childbirth in Singapore. A cross-sectional descriptive correlational study was conducted in a public tertiary hospital in Singapore. A total of 182 first-time fathers whose wives were hospitalized at four obstetric wards were recruited from November 2015 to January 2016. Data were collected by three newly developed and validated instruments, namely Father's Involvement in Pregnancy and Childbirth, Father's Informational and Sources of Support, and Father's Attitude Towards Involvement in Pregnancy and Childbirth, as well as the 16-item Couple Satisfaction Index and Family of Origin Questionnaire. The participants were generally involved in their wives' pregnancy and childbirth, with 35.2% being highly involved. There was no significant difference in fathers' levels of involvement between or among any sociodemographic subgroups. Significant Spearman's correlations were found between fathers' levels of involvement and levels of informational support as well as fathers' attitudes towards involvement. However, the logistic regression showed the level of informational support was the only significant factor that influenced first-time fathers' high levels of involvement in their wives' pregnancy and childbirth. The study revealed the importance of providing sufficient informational support to first-time fathers so that they can be highly involved in their wife's pregnancy and childbirth. Future studies can develop technology-based intervention programmes to improve fathers' involvement in their wife's pregnancy and childbirth. Healthcare professionals should examine and improve the existing informational support for first-time fathers and ensure its relevance and convenient access. Copyright © 2018 Elsevier Ltd. All rights reserved.

  20. Time, science and consensus: the different times involving scientific research, political decision and public opinion

    Directory of Open Access Journals (Sweden)

    José Aparecido de

    2010-01-01

    Full Text Available This essay analyses the asymmetrical relationship between the time of scientific research and the time of the different segments interested in their results, focusing mainly on necessity to establish technical consensus about the fields of science that require rigorous investigations and texts. In the last years, civil society sectors - mainly scientific journalism, legislative power, and public opinion - has shown growing interest in participating of the decision making process that regulates science routes. In this study, we analyzed the decision making process of the Biosafety Law, as it allows research with embryonic stem cells in Brazil. The results allow us to conclude that this asymmetrical relationship between the different times (of science, scientific disclosure, public opinion, and public power contribute to the maturing of the dialog on scientific policies, as well as to the establishment of a consensus concerning science routes, which aims at the democratization of scientific work.

  1. Improving productivity through more effective time management.

    Science.gov (United States)

    Arnold, Edwin; Pulich, Marcia

    2004-01-01

    Effective time management has become increasingly important for managers as they seek to accomplish objectives in today's organizations, which have been restructured for efficiency while employing fewer people. Managers can improve their ability to manage time effectively by examining their attitudes toward time, analyzing time-wasting behaviors, and developing better time management skills. Managers can improve their performance and promotion potential with more effective time utilization. Strategies for improving time management skills are presented.

  2. Has patients' involvement in the decision-making process changed over time?

    NARCIS (Netherlands)

    Brink-Muinen, A. van den; Dulmen, A.M. van; Haes, H.C.J.M. de; Visser, A.P.; Schellevis, F.G.; Bensing, J.M.

    2006-01-01

    Objective: To get insight into the changes over time of patients' involvement in the decision-making process, and into the factors contributing to patients' involvement and general practitioners' (GPs) communication related to the Medical Treatment Act (MTA) Issues: information about treatment,

  3. Has patients’ involvement in the decision-making process changed over time?

    NARCIS (Netherlands)

    Brink-Muinen, A. van den; Dulmen, S.M. van; Haes, H.C.J.M. de; Visser, A.P.; Schellevis, F.G.; Bensing, J.

    2006-01-01

    Objective To get insight into the changes over time of patients’ involvement in the decision-making process, and into the factors contributing to patients’ involvement and general practitioners’ (GPs) communication related to the Medical Treatment Act (MTA) issues: information about treatment,

  4. Understanding the benefits of product-service system for involved parties in remanufacturing

    International Nuclear Information System (INIS)

    Priyono, A.

    2017-01-01

    This study aims to analyse the benefit provided by interested parties in remanufacturing including manufacturing companies, original equipment manufacturers and customers. Existing studies examining Produc-Service System (PSS) focus on relationship between two parties, either between OEMs and customers or between remanufacturers with customers. This study attempts to fill the gap by investigating how the PSS offers benefit to OEMs, remanufacturers and customers. Methodology: This research used case study method to examine the practice of PSS in remanufacturing companies. Qualitative approach was employed to analyse emerging problems in the case companies and the researcher collaborate with the involved parties to create new knowledge. Thus, this process can offer theoretical insights as well as practical insights. Findings: All parties involved in PSS consistently gain benefit from adopting the practice. From the perspective of remanufacturers, the major benefit of remanufacturers adopting PSS is that it can help reduce the uncertainties regarding time, quantity and quality of returned cores. Due to reduced uncertainties, remanufacturers gain benefit from higher profitability and more environmental friendly products. These benefits provide multiplier effects to both customers and OEMs. Practical implications: This study offers benefits to managers in the sense that it provides guidance for managers of remanufacturers to better manage remanufacturing operation so that it becomes more environmentally friendly and economically profitable. Originality/value: It is the first time that the benefits of PSS to support remanufacturing are viewed from integrative perspective – i.e. manufacturers, remanufacturers, and customers.

  5. Understanding the benefits of product-service system for involved parties in remanufacturing

    Directory of Open Access Journals (Sweden)

    Anjar Priyono

    2017-05-01

    Full Text Available Purpose: This study aims to analyse the benefit provided by interested parties in remanufacturing including manufacturing companies, original equipment manufacturers and customers. Existing studies examining Produc-Service System (PSS focus on relationship between two parties, either between OEMs and customers or between remanufacturers with customers. This study attempts to fill the gap by investigating how the PSS offers benefit to OEMs, remanufacturers and customers. Methodology: This research used case study method to examine the practice of PSS in remanufacturing companies. Qualitative approach was employed to analyse emerging problems in the case companies and the researcher collaborate with the involved parties to create new knowledge. Thus, this process can offer theoretical insights as well as practical insights. Findings: All parties involved in PSS consistently gain benefit from adopting the practice. From the perspective of remanufacturers, the major benefit of remanufacturers adopting PSS is that it can help reduce the uncertainties regarding time, quantity and quality of returned cores. Due to reduced uncertainties, remanufacturers gain benefit from higher profitability and more environmental friendly products. These benefits provide multiplier effects to both customers and OEMs. Practical implications: This study offers benefits to managers in the sense that it provides guidance for managers of remanufacturers to better manage remanufacturing operation so that it becomes more environmentally friendly and economically profitable. Originality/value: It is the first time that the benefits of PSS to support remanufacturing are viewed from integrative perspective – i.e. manufacturers, remanufacturers, and customers.

  6. Understanding the benefits of product-service system for involved parties in remanufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Priyono, A.

    2017-07-01

    This study aims to analyse the benefit provided by interested parties in remanufacturing including manufacturing companies, original equipment manufacturers and customers. Existing studies examining Produc-Service System (PSS) focus on relationship between two parties, either between OEMs and customers or between remanufacturers with customers. This study attempts to fill the gap by investigating how the PSS offers benefit to OEMs, remanufacturers and customers. Methodology: This research used case study method to examine the practice of PSS in remanufacturing companies. Qualitative approach was employed to analyse emerging problems in the case companies and the researcher collaborate with the involved parties to create new knowledge. Thus, this process can offer theoretical insights as well as practical insights. Findings: All parties involved in PSS consistently gain benefit from adopting the practice. From the perspective of remanufacturers, the major benefit of remanufacturers adopting PSS is that it can help reduce the uncertainties regarding time, quantity and quality of returned cores. Due to reduced uncertainties, remanufacturers gain benefit from higher profitability and more environmental friendly products. These benefits provide multiplier effects to both customers and OEMs. Practical implications: This study offers benefits to managers in the sense that it provides guidance for managers of remanufacturers to better manage remanufacturing operation so that it becomes more environmentally friendly and economically profitable. Originality/value: It is the first time that the benefits of PSS to support remanufacturing are viewed from integrative perspective – i.e. manufacturers, remanufacturers, and customers.

  7. Patient involvement in a scientific advisory process: setting the research agenda for medical products.

    NARCIS (Netherlands)

    Elberse, J.E.; Pittens, C.A.C.M.; de Cock Buning, J.T.; Broerse, J.E.W.

    2012-01-01

    Patient involvement in scientific advisory processes could lead to more societally relevant advice. This article describes a case study wherein the Health Council of the Netherlands involved patient groups in an advisory process with a predefined focus: setting a research agenda for medical products

  8. Influence of dispatching rules on average production lead time for multi-stage production systems.

    Science.gov (United States)

    Hübl, Alexander; Jodlbauer, Herbert; Altendorfer, Klaus

    2013-08-01

    In this paper the influence of different dispatching rules on the average production lead time is investigated. Two theorems based on covariance between processing time and production lead time are formulated and proved theoretically. Theorem 1 links the average production lead time to the "processing time weighted production lead time" for the multi-stage production systems analytically. The influence of different dispatching rules on average lead time, which is well known from simulation and empirical studies, can be proved theoretically in Theorem 2 for a single stage production system. A simulation study is conducted to gain more insight into the influence of dispatching rules on average production lead time in a multi-stage production system. We find that the "processing time weighted average production lead time" for a multi-stage production system is not invariant of the applied dispatching rule and can be used as a dispatching rule independent indicator for single-stage production systems.

  9. CONSUMER INVOLVEMENT IN BUYING DECISIONS – THE EXAMPLE OF THREE FOOD PRODUCTS IN CROATIA

    Directory of Open Access Journals (Sweden)

    Jerko MARKOVINA

    2005-01-01

    Full Text Available The goal of this research was to create an instrument suitable for the measurement of consumer involvement construct and to verify its metric characteristics. The involvement scale was tested on a sample of 283 consumers of wine, cheese and honey. The statistical analysis of results showed satisfactory validity and reliability of the instrument. High level of consumer involvement was found for wine and cheese, whereas consumer involvement for honey was somewhat lower. These results show that consumers, when buying wine, cheese and honey, do not make their buying decisions impulsively, but they search for the additional information about the products. The scale used in this article can also be used to measure involvement levels for different food and other products in the Croatian market.

  10. Production Planning with Load Dependent Lead Times

    DEFF Research Database (Denmark)

    Pahl, Julia

    2005-01-01

    Lead times impact the performance of the supply chain significantly. Although there is a large literature concerning queuing models for the analysis of the relationship between capacity utilization and lead times, and there is a substantial literature concerning control and order release policies...... that take lead times into consideration, there have been only few papers describing models at the aggregate planning level that recognize the relationship between the planned utilization of capacity and lead times. In this paper we provide an in-depth discussion of the state-of-the art in this literature......, with particular attention to those models that are appropriate at the aggregate planning level....

  11. EFFECTIVE SAVINGS IN PRODUCTION TIMES AND COST

    African Journals Online (AJOL)

    ES OBE

    lamination process itself [5,6,7]. The purpose of this work is to fully expose, by means of experimental data, the ... takes staff to laminate such work piece (in cases of handlay-up processes) and machines. (for resin injection .... The unfinished layer of mat being laminated usually result in laminate products with rough surfaces ...

  12. Technical investigation of a pyrophoric event involving corrosion products from HEU ZPPR fuel plates

    International Nuclear Information System (INIS)

    Totemeier, T. C.

    2000-01-01

    A pyrophoric event recently occurred which involved corrosion products collected from highly-enriched uranium (HEU) fuel plates used in the Zero Power Physics Reactor (ZPPR). This paper summarizes the event and its background, and presents the results of an investigation into its source and mechanism. The investigation focused on characterization of corrosion product samples similar to those involved in the event using thermo-gravimetric analysis (TGA). Burning curve TGA tests were performed to measure the ignition temperature and hydride fractions of corrosion products in several different conditions to assess the effects of passivation treatment and long-term storage on chemical reactivity. The hydride fraction and ignition temperature of the corrosion products were found to be strongly dependent on the corrosion extent of the source metal. The results indicate that the energy source for the event was a considerable quantity of uranium hydride present in the corrosion products, but the specific ignition mechanism could not be identified

  13. Consumer involvement with products: comparison of PII and NIP scales in the Brazilian context

    Directory of Open Access Journals (Sweden)

    Victor Manoel Cunha de Almeida

    2014-05-01

    Full Text Available This study aims to evaluate the extent to which two scales of consumer involvement with products converge: PII (Personal Involvement Inventory, by Zaichkowsky (1994, and NIP (New Involvement Profile, by Jain and Srinivasan (1990. The literature review encompasses the main studies on measuring the involvement of consumers with products. Data was collected through a survey that was applied to a nonprobabilistic quota sample of undergraduate students from different institutions across the state of Rio de Janeiro. A total of 1,122 questionnaires were collected, of which 1,025 (91.4% were considered valid. In order to investigate the different levels of consumer involvement through different product categories, four products were used – sneakers, mobile phone, sports drinks and soft drinks. ANOVA and post hoc tests were used to verify the existence of significant difference on answers among product groups. This study’s substantive hypothesis, the degree of convergence between the classification results of the PII and NIP scales, was verified in two ways: through Spearman’s non-parametric correlation test and through the observation of the scales’ similar classification proportion rates. The scores’ independence was evaluated through the nonparametric Chi-Square test. Results show high classification convergence. The main contribution of this study is thus to empirically test the PII and NIP scales in the Brazilian context. Furthermore, the convergence of the scores of these scales suggests the possibility of comparing results of studies, using either scale.

  14. THE EFFECT OF BRAND LOYALTY OF INVOLVEMENT TO PRODUCTS: THE SAMPLE OF MOBILE PHONE

    OpenAIRE

    Armagan, Ece; Akel, Gokhan

    2017-01-01

    Brands in a highly competitive environment is consideredas the main assets of businesses, businesses that create brand loyalty ensuresthat there is a long period of time. In order to ensure brand loyalty alsoconsumers’ involvement need to be investigated. Brand loyalty is also a greatbenefit in understanding consumers' level of involvement on the brand. Theproduct involvement required to understand consumer behavior is an importantfactor on brand loyalty. In this study, the effect of the...

  15. Product involvement and consumer food-elicited emotional associations: Insights from emoji questionnaires.

    Science.gov (United States)

    Jaeger, Sara R; Lee, Pui-Yee; Ares, Gastón

    2018-04-01

    Individual differences in food-related consumer behaviour are well documented, but lack thorough exploration in relation to product-elicited emotional associations. In this research, focus is directed to product involvement as a factor that modulates emotional associations to tasted products (dried fruit, n = 4) and written descriptions of consumption situations (drinking red wine, cooking dinner using seafood). Emoji questionnaires were used (as check-all-that-apply questions: CATA), and across two studies with consumers in New Zealand (n = 352) and China (n = 450), higher levels of involvement were associated with more positive emotional associations. For example, consumers with higher involvement for dried fruit used emoji with positive meanings (e.g., face savouring delicious food (), smiling face with heart-shaped eyes () and smiling face with smiling eyes () more frequently than those with lower levels of involvement. Conversely, emoji with negative or neutral meanings (e.g., confused face (), confounded face (), neutral face ()), were more frequently used by consumers with lower levels of product involvement. The number of significant differences between the samples of dried fruit were lower in the less involved consumer segment, and these consumers, on average, used less emoji to characterise the samples. A similar pattern of results were established for the written stimuli, which were used with Chinese consumers. For example, in the segment with greater involvement with seafood, associations to emoji with positive meanings were higher when responding to the situation "cooking dinner using frozen seafood as one of the ingredients." In the case of "drinking French red wine," the strategy used to define segments (median vs. triadic split of summed involvement scores) additionally influenced the results, and bigger differences were established when comparing more discrete segments (two extreme groups following triadic split). Copyright © 2018

  16. THE EFFECT OF DISSOLVED WORKPLACE ROMANCES ON THE PSYCHOSOCIAL FUNCTIONING AND PRODUCTIVITY OF THE EMPLOYEES INVOLVED

    Directory of Open Access Journals (Sweden)

    Verhoef, Hendrika

    2015-09-01

    Full Text Available This paper reports on research that explored the effects of dissolved romances on the psychosocial functioning and productivity of the employees involved at an industrial clothing factory in Cape Town in 2012-2013. Also explored is the consequent need for appropriate intervention through the existing Employee Assistance Programme (EAP. A qualitative research approach is applied. The main conclusion confirms the overall negative effect of the breakdown of workplace romances on the psychosocial functioning and productivity of the employees involved in the workplace and gives an indication of how the EAP could most effectively respond to this phenomenon. Mediation as a possible strategy is recommended to deal with workplace romances.

  17. Quality & timely delivery of products and services

    Energy Technology Data Exchange (ETDEWEB)

    Scott, K.; Shabbir, K. [WorleyParsons, Toronto, ON (Canada)

    2015-07-01

    This paper discusses quality and timely delivery of services. The approach is to support our customers, to ensure quality, schedule and cost predictability with no compromise to safety, to avoid optimistic project schedules and conservative cost estimates. It is important to maintain a strategic focus in helping to improve the customer's assets and improve the methodology to improve assets.

  18. Quality & timely delivery of products and services

    International Nuclear Information System (INIS)

    Scott, K.; Shabbir, K.

    2015-01-01

    This paper discusses quality and timely delivery of services. The approach is to support our customers, to ensure quality, schedule and cost predictability with no compromise to safety, to avoid optimistic project schedules and conservative cost estimates. It is important to maintain a strategic focus in helping to improve the customer's assets and improve the methodology to improve assets.

  19. Effects of deceptive packaging and product involvement on purchase intention: an elaboration likelihood model perspective.

    Science.gov (United States)

    Lammers, H B

    2000-04-01

    From an Elaboration Likelihood Model perspective, it was hypothesized that postexposure awareness of deceptive packaging claims would have a greater negative effect on scores for purchase intention by consumers lowly involved rather than highly involved with a product (n = 40). Undergraduates who were classified as either highly or lowly (ns = 20 and 20) involved with M&Ms examined either a deceptive or non-deceptive package design for M&Ms candy and were subsequently informed of the deception employed in the packaging before finally rating their intention to purchase. As anticipated, highly deceived subjects who were low in involvement rated intention to purchase lower than their highly involved peers. Overall, the results attest to the robustness of the model and suggest that the model has implications beyond advertising effects and into packaging effects.

  20. Internal dosimetry from IPEN workers involved in the medical radioisotopes production

    International Nuclear Information System (INIS)

    Cesar, R.B.P.; Mesquita, C.H. de

    1988-01-01

    The internal dose from IPEN workers involved in the medical radioisotopes products is related. In the workers population, six groups were classified: development and research, routine production, quality control, package, radioprotection supervision and maintenance. The internal doses were calculated according to the methodology described by the ICRP-30, using resuls from a whole-body counter. The results described were obtained from 970 whole-body radioactivity measurements during the last three years (1985 a 1987). (author) [pt

  1. TIME MANAGEMENT - AN INSTRUMENT TO IMPROVE PRODUCTIVITY

    Directory of Open Access Journals (Sweden)

    Johan Nortje

    2012-01-01

    Full Text Available

    ENGLISH ABSTRACT: TIME is an Important element in any persons life as a plannlng mechanlsm to meaningfully organIse activities, or to ensure that a oroject runs WIth but also as a generator of destructive forces over it is lost. In the process of growth and progress ln a dynamIC everchanging envIronment. tIme not only becomes dearer to management, but also $carcet-, and an era of "time poverty" is experienced by many. A varIety of uncontrollable factors may be the cause of such problems, but a danger eXIsts that those factors over which control may be exercised could be lost within the uncontrol labie ones. The objective of this artIcle on tIme management is then to assist in identIfying those "barriers" which lead to "time pover'ty", how to avoid and prevent tIme wastage and apply methods, and make use of ways to promote the effective use of tIme.

    AFRIKAANSE OPSOMMING: TYD is 'n belangrlke faktor In dIe lewe van dIe mens enersyds dlen dlt as 'n beplannlngsmeganlsme am jOU daaglikse aktiwitelte slnvol te orden of am 'n pro.lek met preS1Sle te laat verloop, maar andersvds kan dlt ook vernietigende kragte genereer lndlen 'n mens daaroor beheer verloor. In die proses van groel en voorultgang In 'n dinamles veranderende omgewlng, raak dIe tyd van bestuur nle aIleen kosbaarder n ie, maarook skaar'ser en 'n era van' tydarmoede' word deur ba i e ervaar·. ' n Verskel denhe 1d van onbehee rbare faktore mag hiervoor verantwoordeilk wees, maar dIe gevaar bestaan dat die mens dle greep op dIe beheerbare faktore mag verloor. Die DOEL met hierdle artlkel oor tydsbestuur IS jU1S om behulpsaam te wees met dIe ldentiflsering van "slaggate" wat tot'tydat-moede" aanlelding gee. hoe am tydverkwlstlng te voorkom of te hanteer en die toepassing van metodes en gebruik van hulpmiddels om effektiewe tydsbestuur te bevorder.

  2. Relevance and feasibility of women's involvement in promoting sustainable food production and security in Southern Africa

    Directory of Open Access Journals (Sweden)

    Never Assan

    2014-09-01

    Full Text Available Harnessing women’s potential for food production and security has been a challenge in Southern Africa. The face of food production in Southern Africa is often female, but more often than not, their roles are generally undervalued and constrained by gender inequalities and limitations on their access to resources, services, and market opportunities. This chapter explores how women involvement in food production can have a positive impact on food security in Southern Africa. The gender aspect of food security assume significance, as it is widely recognized that women are the custodian of food production in many communities in Southern Africa. There is a tendency of men and women participating unevenly in food production, have unequal access to productive resources and exhibit different levels of engagement in rural, urban and home-based food production. Despite this anomaly, there is still a common understanding that food production needs to be increased in order to cope with the increased human population and achieving food security in the region. With this in mind, food production and security have emerged as key development targets in Southern Africa. This has propelled the urgent need for promoting food production, reducing food insecurity and poverty reduction in its totality. One of the factors contributing to perpetual low food production and insecurity has been gender discrimination and/or lack of participation of women in agricultural programs and projects. In this chapter there is an attempt to describe the impact of gender-based discrimination on food production and its implication on food security. The indispensable role and challenges faced by women in food production are highlighted. The need to invest in education and training of women to support food production systems in order to accrue maximum benefit is acknowledged. In this regard, it is imperative that planning and implementation of any food production programs focusing on

  3. Humor and Comparatives in Ads for High- and Low-Involvement Products.

    Science.gov (United States)

    Wu, Bob T. W.; And Others

    1989-01-01

    Investigates the effectiveness of humor in advertising, comparative advertising, and consumer involvement with the product. Finds that humorous ads are more eye catching but less impressive and less sufficient in information than nonhumorous ads. Finds the performance of comparative ads is generally negative and especially so in the high…

  4. Managing Supplier Involvement in New Product Development: A Multiple-Case Study

    NARCIS (Netherlands)

    F.E.A. van Echtelt (Ferrie); J.Y.F. Wynstra (Finn); A.J. van Weele (Arjan); G.M. Duysters (Geert)

    2006-01-01

    textabstractExisting studies of supplier involvement in new product development have mainly focused on project-related short-term processes and success-factors. This study validates and extends an existing exploratory framework, which comprises both long-term strategic processes and short-term

  5. Managing supplier involvement in new product development : a multiple-case study

    NARCIS (Netherlands)

    Echtelt, van F.E.A.; Wynstra, J.Y.F.; Weele, van A.J.; Duysters, G.M.

    2008-01-01

    Existing studies of supplier involvement in new product development have mainly focused on project-related short-term processes and success factors. This study validates and extends an existing exploratory framework, which comprises both long-term strategic processes and short-term operational

  6. Being Involved in the Country: Productive Ageing in Different Types of Rural Communities

    Science.gov (United States)

    Davis, Sandra; Crothers, Natalie; Grant, Jeanette; Young, Sari; Smith, Karly

    2012-01-01

    Productive ageing recognises the contribution of older people to economic, social and cultural growth and helps build a sustainable community. Being involved in community life is good for individuals and good for society. However, we know very little about the participation of and contribution by people aged 50 and over in rural communities. This…

  7. ABC transporters from Aspergillus nidulans are involved in protection against cytotoxic agents and antibiotic production

    NARCIS (Netherlands)

    Andrade, A.C.; Nistelrooy, van J.G.M.; Peery, R.B.; Skatrud, P.L.; Waard, de M.A.

    2000-01-01

    This paper describes the characterization of atrC and atrD (ABC transporters C and D), two novel ABC transporter-encoding genes from the filamentous fungus Aspergillus nidulans, and provides evidence for the involvement of atrD in multidrug transport and antibiotic production. BLAST analysis of the

  8. Influence of involvement and motivation to correction on product evaluation: Asymmetry for strong and weak brands

    Directory of Open Access Journals (Sweden)

    Styśko-Kunkowska Małgorzata A.

    2014-12-01

    Full Text Available In previous research, studies on motivated correction in the evaluation of branded products are rare. This experimental study with 246 participants examined how the motivation to correct the impact of brand knowledge influences the product evaluation of actual strong and weak brands in low and high involvement situations. As predicted, asymmetry between the strong and weak brands was observed. After the induction of the motivation to correction, the smaller brand effect occurred only in the cases of low involvement and the weak (negative brand. The effect of motivated correction was smaller than the effect of high involvement; therefore, the overall results suggest that conscious explicit motivation to correction evokes correction only in cases of weak brands under certain circumstances. However, this impact is not as strong as the influence of high motivation or a strong brand, even though explicit instructions are given to avoid the negative influence of the brand.

  9. Effect of herd cues and product involvement on bidder online choices.

    Science.gov (United States)

    Chen, Yi-Fen; Wang, Ya-Ju

    2010-08-01

    Previous works have shown that consumers are influenced by others in decision making. Herd behavior is common in situations in which consumers infer product quality from other consumer choices and incorporate that information into their own decision making. This research presents two studies examining herd effect and the moderating role of product involvement on bidder choices in online auctions. The two studies addressed the influence on bidder online choices of herd cues frequently found in online auctions, including feedback ratings and number of questions and answers. The experimental results demonstrated that bidders use online herd cues when making decisions in online auctions. Additionally, the effects of herd cues on bidder online choices were stronger in high-involvement than low-involvement participants. Results and implications are discussed.

  10. Developmental changes in brain activation involved in the production of novel speech sounds in children.

    Science.gov (United States)

    Hashizume, Hiroshi; Taki, Yasuyuki; Sassa, Yuko; Thyreau, Benjamin; Asano, Michiko; Asano, Kohei; Takeuchi, Hikaru; Nouchi, Rui; Kotozaki, Yuka; Jeong, Hyeonjeong; Sugiura, Motoaki; Kawashima, Ryuta

    2014-08-01

    Older children are more successful at producing unfamiliar, non-native speech sounds than younger children during the initial stages of learning. To reveal the neuronal underpinning of the age-related increase in the accuracy of non-native speech production, we examined the developmental changes in activation involved in the production of novel speech sounds using functional magnetic resonance imaging. Healthy right-handed children (aged 6-18 years) were scanned while performing an overt repetition task and a perceptual task involving aurally presented non-native and native syllables. Productions of non-native speech sounds were recorded and evaluated by native speakers. The mouth regions in the bilateral primary sensorimotor areas were activated more significantly during the repetition task relative to the perceptual task. The hemodynamic response in the left inferior frontal gyrus pars opercularis (IFG pOp) specific to non-native speech sound production (defined by prior hypothesis) increased with age. Additionally, the accuracy of non-native speech sound production increased with age. These results provide the first evidence of developmental changes in the neural processes underlying the production of novel speech sounds. Our data further suggest that the recruitment of the left IFG pOp during the production of novel speech sounds was possibly enhanced due to the maturation of the neuronal circuits needed for speech motor planning. This, in turn, would lead to improvement in the ability to immediately imitate non-native speech. Copyright © 2014 Wiley Periodicals, Inc.

  11. Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement

    Science.gov (United States)

    Alrashdan, Yazan A.; Alkhouri, Hatem; Chen, Emily; Lalor, Daniel J.; Poniris, Maree; Henness, Sheridan; Brightling, Christopher E.; Burgess, Janette K.; Armour, Carol L.; Ammit, Alaina J.

    2012-01-01

    CXCL10 (IP10) is involved in mast cell migration to airway smooth muscle (ASM) bundles in asthma. We aimed to investigate the role of cytokine-induced MAPK activation in CXCL10 production by ASM cells from people with and without asthma. Confluent growth-arrested ASM cells were treated with inhibitors of the MAPKs ERK, p38, and JNK and transcription factor NF-κB, or vehicle, and stimulated with IL-1β, TNF-α, or IFN-γ, alone or combined (cytomix). CXCL10 mRNA and protein, JNK, NF-κB p65 phosphorylation, and Iκ-Bα protein degradation were assessed using real-time PCR, ELISA, and immunoblotting, respectively. Cytomix, IL-1β, and TNF-α induced CXCL10 mRNA expression more rapidly in asthmatic than nonasthmatic ASM cells. IL-1β and/or TNF-α combined with IFN-γ synergistically increased asthmatic ASM cell CXCL10 release. Inhibitor effects were similar in asthmatic and nonasthmatic cells, but cytomix-induced release was least affected, with only JNK and NF-κB inhibitors halving it. Notably, JNK phosphorylation was markedly less in asthmatic compared with nonasthmatic cells. However, in both, the JNK inhibitor SP600125 reduced JNK phosphorylation and CXCL10 mRNA levels but did not affect CXCL10 mRNA stability or Iκ-Bα degradation. Together, the JNK and NF-κB inhibitors completely inhibited their CXCL10 release. We concluded that, in asthmatic compared with nonasthmatic ASM cells, JNK activation was reduced and CXCL10 gene expression was more rapid following cytomix stimulation. However, in both, JNK activation did not regulate early events leading to NF-κB activation. Thus JNK and NF-κB provide independent therapeutic targets for limiting CXCL10 production and mast cell migration to the ASM in asthma. PMID:22387292

  12. Essential time management how to become more productive and effective

    CERN Document Server

    Hilder, Brett

    2011-01-01

    Time is a resource like any other. Using your time effectively can transform your personal productivity and determine your level of success. Moreover, it can change your level of job satisfaction and confidence.

  13. Electric Car Users’ Time of Charging Problem under Peak Load Pricing When Delay in Charging Time Involves Uncertain Cost

    DEFF Research Database (Denmark)

    Fetene, Gebeyehu Manie

    The problem of peak load arises when demand fluctuates over time while the pro- duction technology is not flexible (or making it flexible is economically inefficient) and/or when a product is non-storable (or storage cost is huge). Peak load is a com- mon problem in consumption of public utilities......, on the one hand, observed cost saving benefit of postponing the time of charging to off-peak lower fee of charging and, on the other hand, the cost of delay in departure time for planned trips and uncertain cost of late charging associated with likelihood occur- rence of unanticipated trip before the car...... of electricity. The electric vehicle (EV) users choice of time of charging problem under PLP is different from that of general households using energy for house appliances since there is uncertain cost to the former as- sociated with likelihood occurrence of unanticipated trips such as visiting hospital...

  14. Heuristics for the Economic Production Quantity Problem under Restrictions on Production and Maintenance Time

    Directory of Open Access Journals (Sweden)

    Qi Xu

    2016-01-01

    Full Text Available This paper proposes an economic production quantity problem with the maximal production run time and minimal preventive maintenance time over a finite planning horizon. The objective is to find the efficient production and maintenance policy to minimize the total cost composed of production, maintenance, shortages, and holding costs under the restriction on the production run time and the preventive maintenance time. The production and maintenance decisions include the production and maintenance frequencies and the production run and the maintenance time. The variability and the boundedness of the production run and maintenance time make the problem difficult to solve. Two heuristic algorithms are developed using different techniques based on the optimal properties of the relaxed problem. The performance comparison between the two algorithms is illustrated by numerical examples. The numerical results show that, for the most part, there exists a heuristic algorithm which is more effective than the other.

  15. Production planning of a perishable product with lead time and non-stationary demand

    NARCIS (Netherlands)

    Pauls-Worm, K.G.J.; Haijema, R.; Hendrix, E.M.T.; Rossi, R.; Vorst, van der J.G.A.J.

    2012-01-01

    We study a production planning problem for a perishable product with a fixed lifetime, under a service-level constraint. The product has a non-stationary stochastic demand. Food supply chains of fresh products like cheese and several crop products, are characterised by long lead times due to

  16. Buyer-Supplier Collaboration in New Product Development - Reduction of Ramp-up time for high-tech products

    OpenAIRE

    Nielsen, Halvor Eid

    2015-01-01

    Product development has always been a key activity to gain competitive advantage. Especially in technology based industry, such as the maritime subsea industry. Due to increasing globalization and high competition from low cost countries, companies need to streamline the supply chain and development in order to get new product out on the market fast and efficient. Involving suppliers in the development have shown great effect on reduced development time and cost while increasing quality of...

  17. Understanding the differentiating impacts of the communication strategies of a high involvement service (investment advisory services) and a high involvement product (precious jewellery) on customer satisfaction and loyalty.

    OpenAIRE

    Gupta, Gauri

    2009-01-01

    While marketing literature has largely focused on high and low involvement purchases and the positive relationship between customer satisfaction and loyalty; the differentiating impacts of communication strategies for a high involvement service and a high involvement product on customer satisfaction and loyalty has received little academic attention. Consequently, this study examines the differentiating impacts of the communication strategies for investment advisory services and precious jewe...

  18. Influence of Employee Involvement in Total Productive Maintenance Practices on Job Characteristics: The Malaysian Scenario

    Directory of Open Access Journals (Sweden)

    Aizzat Mohd. Nasurdin

    2005-09-01

    Full Text Available The main goal of this study is to examine whether the extent of involvement in Total Productive Maintenance (TPM practices has a positive effect on job characteristics. Data was gathered from a sample of 184 respondents derived from manufacturing companies in Malaysia. Results from the regression analyses revealed that the extent of employee’s involvement in TPM practices is positively related to the five core job dimensions (skill variety, task identity, task significance, autonomy, and feedback. Theoretical and managerial implications of the findings are discussed.

  19. Certain fractional integral formulas involving the product of generalized Bessel functions.

    Science.gov (United States)

    Baleanu, D; Agarwal, P; Purohit, S D

    2013-01-01

    We apply generalized operators of fractional integration involving Appell's function F 3(·) due to Marichev-Saigo-Maeda, to the product of the generalized Bessel function of the first kind due to Baricz. The results are expressed in terms of the multivariable generalized Lauricella functions. Corresponding assertions in terms of Saigo, Erdélyi-Kober, Riemann-Liouville, and Weyl type of fractional integrals are also presented. Some interesting special cases of our two main results are presented. We also point out that the results presented here, being of general character, are easily reducible to yield many diverse new and known integral formulas involving simpler functions.

  20. Certain Fractional Integral Formulas Involving the Product of Generalized Bessel Functions

    Science.gov (United States)

    Baleanu, D.; Agarwal, P.; Purohit, S. D.

    2013-01-01

    We apply generalized operators of fractional integration involving Appell's function F 3(·) due to Marichev-Saigo-Maeda, to the product of the generalized Bessel function of the first kind due to Baricz. The results are expressed in terms of the multivariable generalized Lauricella functions. Corresponding assertions in terms of Saigo, Erdélyi-Kober, Riemann-Liouville, and Weyl type of fractional integrals are also presented. Some interesting special cases of our two main results are presented. We also point out that the results presented here, being of general character, are easily reducible to yield many diverse new and known integral formulas involving simpler functions. PMID:24379745

  1. Least-squares methods involving the H{sup -1} inner product

    Energy Technology Data Exchange (ETDEWEB)

    Pasciak, J.

    1996-12-31

    Least-squares methods are being shown to be an effective technique for the solution of elliptic boundary value problems. However, the methods differ depending on the norms in which they are formulated. For certain problems, it is much more natural to consider least-squares functionals involving the H{sup -1} norm. Such norms give rise to improved convergence estimates and better approximation to problems with low regularity solutions. In addition, fewer new variables need to be added and less stringent boundary conditions need to be imposed. In this talk, I will describe some recent developments involving least-squares methods utilizing the H{sup -1} inner product.

  2. Investigation of large α production in reactions involving weakly bound 7Li

    Science.gov (United States)

    Pandit, S. K.; Shrivastava, A.; Mahata, K.; Parkar, V. V.; Palit, R.; Keeley, N.; Rout, P. C.; Kumar, A.; Ramachandran, K.; Bhattacharyya, S.; Nanal, V.; Palshetkar, C. S.; Nag, T. N.; Gupta, Shilpi; Biswas, S.; Saha, S.; Sethi, J.; Singh, P.; Chatterjee, A.; Kailas, S.

    2017-10-01

    The origin of the large α -particle production cross sections in systems involving weakly bound 7Li projectiles has been investigated by measuring the cross sections of all possible fragment-capture as well as complete fusion using the particle-γ coincidence, in-beam, and off-beam γ -ray counting techniques for the 7Li+93Nb system at near Coulomb barrier energies. Almost all of the inclusive α -particle yield has been accounted for. While the t -capture mechanism is found to be dominant (˜70 % ), compound nuclear evaporation and breakup processes contribute ˜15 % each to the inclusive α -particle production in the measured energy range. Systematic behavior of the t capture and inclusive α cross sections for reactions involving 7Li over a wide mass range is also reported.

  3. Micro wholesaling businesses involved in the sector of confectionary products - strategies of survival and growth

    OpenAIRE

    Raptopoulos, PS

    2011-01-01

    It can be argued that the problematic situation where micro Greek wholesaling businesses find themselves has been a result of the strong presence of supermarkets and superstores in the last years. The researcher attempts to picture the current market reality that constitutes the background of the Thesis by posing the main research question: "How can micro Greek wholesaling businesses involved in the confectionary products' sector identify and implement suitable survival and growth strategies ...

  4. Characterization of uranium corrosion products involved in the March 13, 1998 fuel manufacturing facility pyrophoric event

    International Nuclear Information System (INIS)

    Totemeier, T.C.

    1999-01-01

    Uranium metal corrosion products from ZPPR fuel plates involved in the March 13, 1998 pyrophoric event in the Fuel Manufacturing Facility at Argonne National Laboratory-West were characterized using thermo-gravimetric analysis, X-ray diffraction, and BET gas sorption techniques. Characterization was performed on corrosion products in several different conditions: immediately after separation from the source metal, after low-temperature passivation, after passivation and extended vault storage, and after burning in the pyrophoric event. The ignition temperatures and hydride fractions of the corrosion product were strongly dependent on corrosion extent. Corrosion products from plates with corrosion extents less than 0.7% did not ignite in TGA testing, while products from plates with corrosion extents greater than 1.2% consistently ignited. Corrosion extent is defined as mass of corrosion products divided by the total mass of uranium. The hydride fraction increased with corrosion extent. There was little change in corrosion product properties after low-temperature passivation or vault storage. The burned products were not reactive and contained no hydride; the principal constituents were UO 2 and U 3 O 7 . The source of the event was a considerable quantity of reactive hydride present in the corrosion products. No specific ignition mechanism could be conclusively identified. The most likely initiator was a static discharge in the corrosion product from the 14th can as it was poured into the consolidation can. The available evidence does not support scenarios in which the powder in the consolidation can slowly self-heated to the ignition point, or in which the powder in the 14th can was improperly passivated

  5. Characterization of uranium corrosion products involved in the March 13, 1998 fuel manufacturing facility pyrophoric event.

    Energy Technology Data Exchange (ETDEWEB)

    Totemeier, T.C.

    1999-04-26

    Uranium metal corrosion products from ZPPR fuel plates involved in the March 13, 1998 pyrophoric event in the Fuel Manufacturing Facility at Argonne National Laboratory-West were characterized using thermo-gravimetric analysis, X-ray diffraction, and BET gas sorption techniques. Characterization was performed on corrosion products in several different conditions: immediately after separation from the source metal, after low-temperature passivation, after passivation and extended vault storage, and after burning in the pyrophoric event. The ignition temperatures and hydride fractions of the corrosion product were strongly dependent on corrosion extent. Corrosion products from plates with corrosion extents less than 0.7% did not ignite in TGA testing, while products from plates with corrosion extents greater than 1.2% consistently ignited. Corrosion extent is defined as mass of corrosion products divided by the total mass of uranium. The hydride fraction increased with corrosion extent. There was little change in corrosion product properties after low-temperature passivation or vault storage. The burned products were not reactive and contained no hydride; the principal constituents were UO{sub 2} and U{sub 3}O{sub 7}. The source of the event was a considerable quantity of reactive hydride present in the corrosion products. No specific ignition mechanism could be conclusively identified. The most likely initiator was a static discharge in the corrosion product from the 14th can as it was poured into the consolidation can. The available evidence does not support scenarios in which the powder in the consolidation can slowly self-heated to the ignition point, or in which the powder in the 14th can was improperly passivated.

  6. Metaproteomics and ultrastructure characterization of Komagataeibacter spp. involved in high-acid spirit vinegar production.

    Science.gov (United States)

    Andrés-Barrao, Cristina; Saad, Maged M; Cabello Ferrete, Elena; Bravo, Daniel; Chappuis, Marie-Luise; Ortega Pérez, Ruben; Junier, Pilar; Perret, Xavier; Barja, François

    2016-05-01

    Acetic acid bacteria (AAB) are widespread microorganisms in nature, extensively used in food industry to transform alcohols and sugar alcohols into their corresponding organic acids. Specialized strains are used in the production of vinegar through the oxidative transformation of ethanol into acetic acid. The main AAB involved in the production of high-acid vinegars using the submerged fermentation method belong to the genus Komagataeibacter, characterized by their higher ADH stability and activity, and higher acetic acid resistance (15-20%), compared to other AAB. In this work, the bacteria involved in the production of high-acid spirit vinegar through a spontaneous acetic acid fermentation process was studied. The analysis using a culture-independent approach revealed a homogeneous bacterial population involved in the process, identified as Komagataeibacter spp. Differentially expressed proteins during acetic acid fermentation were investigated by using 2D-DIGE and mass spectrometry. Most of these proteins were functionally related to stress response, the TCA cycle and different metabolic processes. In addition, scanning and transmission electron microscopy and specific staining of polysaccharide SDS-PAGE gels confirmed that Komagataeibacter spp. lacked the characteristic polysaccharide layer surrounding the outer membrane that has been previously reported to have an important role in acetic acid resistance in the genus Acetobacter. Copyright © 2015 Elsevier Ltd. All rights reserved.

  7. Flexibility of production systems and prepare-finish time

    Directory of Open Access Journals (Sweden)

    Vukićević Milan R.

    2006-01-01

    Full Text Available One of the specificities of the large-serial and mass production is the almost neglected percentage of prepare-finish time in the production cycle. In the conditions of today dominant discontinuous production, it becomes a significant element of the production cycle. The eastern (Japan doctrine of increasing the flexibility of the production systems, is based inter alia also on the extreme reduction of the prepare-finish time. For this reason, the aim of this study was to identify the types and percentages of individual jobs within the group of prepare-finish jobs. The sample consisted of 3 (three production systems for the production of joinery, with the discontinuous production system. The research shows that the percentage of time of the jobs installation of work instruments, regulation of processing regime, and removal of work instruments is extremely long and that it ranges between 11.83% and 18.93% of the shift time. The reasons of the high percentage of these jobs are the wide range of products and the absence of the rationalisation of prepare-finish jobs. Within the efforts to minimize the effects of disruption and to increase the flexibility of the production systems, the rationalisation of prepare-finish jobs is the unavoidable condition.

  8. An ecological approach to prospective and retrospective timing of long durations: a study involving gamers.

    Directory of Open Access Journals (Sweden)

    Simon Tobin

    Full Text Available To date, most studies comparing prospective and retrospective timing have failed to use long durations and tasks with a certain degree of ecological validity. The present study assessed the effect of the timing paradigm on playing video games in a "naturalistic environment" (gaming centers. In addition, as it involved gamers, it provided an opportunity to examine the effect of gaming profile on time estimation. A total of 116 participants were asked to estimate prospectively or retrospectively a video game session lasting 12, 35 or 58 minutes. The results indicate that time is perceived as longer in the prospective paradigm than in the retrospective one, although the variability of estimates is the same. Moreover, the 12-minute session was perceived as longer, proportionally, than the 35- and 58-minute sessions. The study also revealed that the number of hours participants spent playing video games per week was a significant predictor of time estimates. To account for the main findings, the differences between prospective and retrospective timing are discussed in quantitative terms using a proposed theoretical framework, which states that both paradigms use the same cognitive processes, but in different proportions. Finally, the hypothesis that gamers play more because they underestimate time is also discussed.

  9. The Effect of Religiosity on Product Involvement in a Muslim Society

    Directory of Open Access Journals (Sweden)

    Dursun Yener

    2014-03-01

    Full Text Available Religion has an important place in social life. It does not only affect the structure of society by shaping behavior and attitudes of people but also is affected from the social construct. Since religion has been perceived as a taboo subject, the number of researches about the relationship between religiosity and marketing are limited. Most of existing papers is relevant to Christianity and other religions. This study aims to present the effect of religiosity on product involvement using Allport’s intrinsic/extrinsic religious orientation scale (ROS in a Muslim sample. Three different product categories were selected (food, cosmetics and cleaning products to analyze. Sample size of the research is 282 people which were selected by convenience sampling method. In metho dology part, correlation and regression analyses and ANOVA and independent sample t-test were used. As a result, participants' level of involvement for each product group is differentiated according to their religiosity orientation. Since the scale was app lied on a Muslim sample in Turkey, the study is also important.

  10. Production and Comprehension of Time Reference in Korean Nonfluent Aphasia

    Science.gov (United States)

    Lee, Jiyeon; Kwon, Miseon; Na, Hae Ri; Bastiaanse, Roelien; Thompson, Cynthia K.

    2015-01-01

    Objectives Individuals with nonfluent agrammatic aphasia show impaired production and comprehension of time reference via verbal morphology. However, cross-linguistic findings to date suggest inconsistent evidence as to whether tense processing in general is impaired or time reference to the past is selectively difficult in this population. This study examined production and comprehension of time reference via verb morphology in Korean-speaking individuals with nonfluent aphasia. Methods A group of 9 healthy controls and 8 individuals with nonfluent aphasia (5 for the production task) participated in the study. Sentence priming production and auditory sentence to picture matching tasks were used, parallel with the previous cross-linguistic experiments in English, Chinese, Turkish, and others. Results The participants with nonfluent aphasia showed different patterns of impairment in production and comprehension. In production, they were impaired in all time references with errors being dominated by substitution of incorrect time references and other morpho-phonologically well-formed errors, indicating a largely intact morphological affixation process. In comprehension, they showed selective impairment of the past, consistent with the cross-linguistic evidence from English, Chinese, Turkish, and others. Conclusion The findings suggest that interpretation of past time reference poses particular difficulty in nonfluent aphasia irrespective of typological characteristics of languages; however, in production, language-specific morpho-semantic functions of verbal morphology may play a significant role in selective breakdowns of time reference. PMID:26290861

  11. GC of catalytic reactions products involved in the promising fuel synthesis

    Energy Technology Data Exchange (ETDEWEB)

    Zheivot, V.; Sazonova, N. [Russian Academy of Sciences, Novosibirsk (Russian Federation). Boreskov Inst. of Catalysis

    2012-09-15

    Catalytic reactions involved in the synthesis of the promising kinds of novel fuel and products formed in these reactions were systematized according to the resulting fuel type. Generalization of the retention of the substances comprising these products is presented. Chromatograms exhibiting their separation on chromatographic materials with the surface of different chemical properties are summarized. We propose procedures for gas-chromatographic analysis of the catalytic reactions products formed in the synthesis of hydrogen, methanol, dimethyl ether and hydrocarbons as a new generation of fuel alternative to petroleum and coal. For partial oxidation of methane into synthesis gas, on-line determination of the components obtained in the reaction was carried out by gas chromatography and gas analyzer based on different physicochemical methods (IR spectroscopy and electrochemical methods). Similarity of the results obtained using these methods is demonstrated. (orig.)

  12. A comparison of five elicitation techniques for elicitation of attributes of low involvement products

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Nielsen, Niels Asger

    1999-01-01

    of dimensions directed from theories of consumer buying behaviour. Although a number of differences between the techniques are identified in the study, the main findings are that the robustness of the different techniques for attribute elicitation is considerable Udgivelsesdato: JUN......The critical first step for most instruments used in analysing consumer choice and motivation is the identification of product attributes which are important to the consumer and for which there are differences among the available product alternatives. A number of techniques, ranging from...... the complex elicitation of idiosyncratic attributes or simpler picking procedures, has been developed to elicitate such attributes. The purpose of the study presented here is to com-pare attributes of a low involvement product, viz. vegetable oil, elicited by five different techniques on a number...

  13. The time of day effects of warm temperature on flowering time involve PIF4 and PIF5

    Science.gov (United States)

    Thines, Bryan C.; Duarte, Maritza I.; Harmon, Frank G.

    2014-01-01

    Warm temperature promotes flowering in Arabidopsis thaliana and this response involves multiple signalling pathways. To understand the temporal dynamics of temperature perception, tests were carried out to determine if there was a daily window of enhanced sensitivity to warm temperature (28 °C). Warm temperature applied during daytime, night-time, or continuously elicited earlier flowering, but the effects of each treatment were unequal. Plants exposed to warm night (WN) conditions flowered nearly as early as those in constant warm (CW) conditions, while treatment with warm days (WD) caused later flowering than either WN or CW. Flowering in each condition relied to varying degrees on the activity of CO , FT , PIF4 , and PIF5 , as well as the action of unknown genes. The combination of signalling pathways involved in flowering depended on the time of the temperature cue. WN treatments caused a significant advance in the rhythmic expression waveform of CO, which correlated with pronounced up-regulation of FT expression, while WD caused limited changes in CO expression and no stimulation of FT expression. WN- and WD-induced flowering was partially CO independent and, unexpectedly, dependent on PIF4 and PIF5 . pif4-2, pif5-3, and pif4-2 pif5-3 mutants had delayed flowering under all three warm conditions. The double mutant was also late flowering in control conditions. In addition, WN conditions alone imposed selective changes to PIF4 and PIF5 expression. Thus, the PIF4 and PIF5 transcription factors promote flowering by at least two means: inducing FT expression in WN and acting outside of FT by an unknown mechanism in WD. PMID:24574484

  14. Evaluation of the stages involved in cold ischemia time in renal transplants in Chile.

    Science.gov (United States)

    Elgueta, S; Fuentes, C; Arenas, A; Labraña, C; Gajardo, J G; Lopez, M; Hernandez, J; Rodriguez, H; Rodriguez, L

    2010-01-01

    Cold ischemia time (CIT) is one of the factors that determine the evolution of a renal transplant; taking measures to reduce this time requires knowledge of its stages. The objective of this study was to evaluate the times in the stages that determine CIT in renal transplants. We analyzed 108 donors and 201 kidney transplantations performed in Chile in 2008, establishing the CIT for the kidney transplanted by the center that extracted the kidneys (local kidney) and for the kidney transplanted in another center (shared kidney). Average CIT was 18.8 hours: namely, 16.9 hours for local and 20.2 hours for shared kidneys (P = .0001484). CIT for cases in which samples were sent to histocompatibility laboratory prior to nephrectomy was 7.3 hours less than for those sent postnephrectomy. The mean time between the allocation of the kidney and the transplant was 7.3 hours; 5.6 hours for local kidneys and 8.4 hours for shared kidneys (P = .000007124). We identified the stages at which intervention is possible to reduce the CIT, mainly for shared kidneys. All involved parties should make an effort to reduce this time.

  15. Study on the Control Strategy of Shifting Time Involving Multigroup Clutches

    Directory of Open Access Journals (Sweden)

    Zhen Zhu

    2016-01-01

    Full Text Available This paper focuses on the control strategy of shifting time involving multigroup clutches for a hydromechanical continuously variable transmission (HMCVT. The dynamic analyses of mathematical models are presented in this paper, and the simulation models are used to study the control strategy of HMCVT. Simulations are performed in Simulation X platform to investigate the shifting time of clutches under different operating conditions. On this basis, simulation analysis and test verification of two typical conditions, which play the decisive roles for the shifting quality, are carried out. The results show that there are differences in the shifting time of the two typical conditions. In the shifting process from the negative transmission of hydromechanical ranges to the positive transmission of hydromechanical ranges, the control strategy based on the shifting time is switching the clutches of shifting mechanism firstly and then disengaging a group of clutches of planetary gear mechanism and engaging another group of the clutches of planetary gear mechanism lastly. In the shifting process from the hydraulic range to the hydromechanical range, the control strategy based on the shifting time is switching the clutches of hydraulic shifting mechanism and planetary gear mechanism at first and then engaging the clutch of shifting mechanism.

  16. Analysis of the enzyme network involved in cattle milk production using graph theory.

    Science.gov (United States)

    Ghorbani, Sholeh; Tahmoorespur, Mojtaba; Masoudi Nejad, Ali; Nasiri, Mohammad; Asgari, Yazdan

    2015-06-01

    Understanding cattle metabolism and its relationship with milk products is important in bovine breeding. A systemic view could lead to consequences that will result in a better understanding of existing concepts. Topological indices and quantitative characterizations mostly result from the application of graph theory on biological data. In the present work, the enzyme network involved in cattle milk production was reconstructed and analyzed based on available bovine genome information using several public datasets (NCBI, Uniprot, KEGG, and Brenda). The reconstructed network consisted of 3605 reactions named by KEGG compound numbers and 646 enzymes that catalyzed the corresponding reactions. The characteristics of the directed and undirected network were analyzed using Graph Theory. The mean path length was calculated to be4.39 and 5.41 for directed and undirected networks, respectively. The top 11 hub enzymes whose abnormality could harm bovine health and reduce milk production were determined. Therefore, the aim of constructing the enzyme centric network was twofold; first to find out whether such network followed the same properties of other biological networks, and second, to find the key enzymes. The results of the present study can improve our understanding of milk production in cattle. Also, analysis of the enzyme network can help improve the modeling and simulation of biological systems and help design desired phenotypes to increase milk production quality or quantity.

  17. Production Time Loss Reduction in Sauce Production Line by Lean Six Sigma Approach

    Science.gov (United States)

    Ritprasertsri, Thitima; Chutima, Parames

    2017-06-01

    In all industries, time losses, which are incurred in processing are very important. As a result, losses are incurred in productivity and cost. This research aimed to reduce lost time that occurs in sauce production line by using the lean six sigma approach. The main objective was to reduce the time for heating sauce which causes a lot of time lost in the production line which affects productivity. The methodology was comprised of the five-phase improvement model of Six Sigma. This approach begins with defining phase, measuring phase, analysing phase, improving phase and controlling phase. Cause-and-effect matrix and failure mode and effect analysis (FMEA) were adopted to screen the factors which affect production time loss. The results showed that the percentage of lost time from heating sauce reduced by 47.76%. This increased productivity to meet the plan.

  18. Attributes of low involvement products: A comparison of five elicitation techniques and a test of their nomological validity

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Nielsen, Niels Asger; Grunert, Klaus G.

    attributes, which are important to consumers, is the critical first step in the majority of consumer behavior studies. 2. A number of techniques, ranging from the complicated elicitation of idiosyncratic attributes, to simpler techniques, as picking from a pre-specified list of attributes, has been developed...... negatively to the abstraction level and the number of attributes involved in the choice task. 4. The purpose of the study presented in this paper is to: (a) compare different elicitation techniques on a number of different criteria, such as: importance to consumers, ability to discriminate between brands......, predictive ability, time use, and number of attributes elicited; and to (b) test the nomological validity of the basic assumptions regarding attributes and consumer choices for a low involvement product (veg oil). 5. The study presented is part of the project Rape seed oil for human consumption. Although...

  19. Involvement of purinergic signaling on nitric oxide production by neutrophils stimulated with Trichomonas vaginalis.

    Science.gov (United States)

    Frasson, Amanda Piccoli; De Carli, Geraldo Attilio; Bonan, Carla Denise; Tasca, Tiana

    2012-03-01

    Trichomonas vaginalis is a parasite from the human urogenital tract that causes trichomonosis, the most prevalent non-viral sexually transmitted disease. The neutrophil infiltration has been considered to be primarily responsible for cytological changes observed at infection site, and the chemoattractants can play an important role in this leukocytic recruitment. Nitric oxide (NO) is one of the most widespread mediator compounds, and it is implicated in modulation of immunological mechanisms. Extracellular nucleotides and nucleosides are signaling molecules involved in several processes, including immune responses and control of leukocyte trafficking. Ectonucleoside triphosphate diphosphohydrolase members, ecto-5'-nucleotidase, and adenosine deaminase (ectoADA) have been characterized in T. vaginalis. Herein, we investigated the effects of purinergic system on NO production by neutrophils stimulated with T. vaginalis. The trophozoites were able to induce a high NO synthesis by neutrophils through iNOS pathway. The extracellular nucleotides ATP, ADP, and ATPγS (a non-hydrolyzable ATP analog) showed no significant change in NO secretion. In contrast, adenosine and its degradation product, inosine, promoted a low production of the compound. The immunosuppressive effect of adenosine upon NO release by neutrophils occurred due to adenosine A(2A) receptor activation. The ecto-5'-nucleotidase activity displayed by T. vaginalis was shown to be important in adenosine generation, indicating the efficiency of purinergic cascade. Our data suggest the influence of purinergic signaling, specifically adenosinergic system, on NO production by neutrophils in T. vaginalis infection, contributing to the immunological aspects of disease.

  20. Effect of Resident Involvement on Operative Time and Operating Room Staffing Costs.

    Science.gov (United States)

    Allen, Robert William; Pruitt, Mark; Taaffe, Kevin M

    The operating room (OR) is a major driver of hospital costs; therefore, operative time is an expensive resource. The training of surgical residents must include time spent in the OR, but that experience comes with a cost to the surgeon and hospital. The objective of this article is to determine the effect of surgical resident involvement in the OR on operative time and subsequent hospital labor costs. The Kruskal-Wallis statistical test is used to determine whether or not there is a difference in operative times between 2 groups of cases (with residents and without residents). This difference leads to an increased cost in associated hospital labor costs for the group with the longer operative time. Cases were performed at Greenville Memorial Hospital. Greenville Memorial Hospital is part of the larger healthcare system, Greenville Health System, located in Greenville, SC and is a level 1 trauma center with up to 33 staffed ORs. A total of 84,997 cases were performed at the partnering hospital between January 1st, 2011 and July 31st, 2015. Cases were only chosen for analysis if there was only one CPT code associated with the case and there were more than 5 observations for each group being studied. This article presents a comprehensive retrospective analysis of 29,134 cases covering 246 procedures. The analysis shows that 45 procedures took significantly longer with a resident present in the room. The average increase in operative time was 4.8 minutes and the cost per minute of extra operative time was determined to be $9.57 per minute. OR labor costs at the partnering hospital was found to be $2,257,433, or $492,889 per year. Knowing the affect on operative time and OR costs allows managers to make smart decisions when considering alternative educational and training techniques. In addition, knowing the connection between residents in the room and surgical duration could help provide better estimates of surgical time in the future and increase the predictability of

  1. 29 CFR 570.64 - Occupations involved in the manufacture of brick, tile, and kindred products (Order 13).

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Occupations involved in the manufacture of brick, tile, and... Detrimental to Their Health or Well-Being § 570.64 Occupations involved in the manufacture of brick, tile, and... term clay construction products shall mean the following clay products: Brick, hollow structural tile...

  2. 29 CFR 570.63 - Occupations involved in the operation of paper-products machines, scrap paper balers, and paper...

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Occupations involved in the operation of paper-products machines, scrap paper balers, and paper box compactors (Order 12). 570.63 Section 570.63 Labor Regulations... involved in the operation of paper-products machines, scrap paper balers, and paper box compactors (Order...

  3. A continuous-time control model on production planning network ...

    African Journals Online (AJOL)

    A continuous-time control model on production planning network. DEA Omorogbe, MIU Okunsebor. Abstract. In this paper, we give a slightly detailed review of Graves and Hollywood model on constant inventory tactical planning model for a job shop. The limitations of this model are pointed out and a continuous time ...

  4. Effect of Retention Time on Biogas Production from Poultry ...

    African Journals Online (AJOL)

    A study was carried out on different retention times in the anaerobic fermentation of slurry from poultry droppings and cassava peels. The system adopted in this work was batch-type. Daily gas production fell slightly from 130 to 32 litres as retention time was increased from 10 to 40 days for poultry droppings. For cassava ...

  5. Torrefaction of agricultural by-products: Effects of temperature and time on energy yields

    Science.gov (United States)

    Agricultural by-products, such as apple, grape, olive, and tomato pomaces as well as almond and walnut shells, were torrefied at different temperatures and times. Torrefaction of biomass involves heating in an inert atmosphere to remove volatile components for improved grindability and increased ene...

  6. Time Domain Partitioning of Electricity Production Cost Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Barrows, C. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hummon, M. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jones, W. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Hale, E. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2014-01-01

    Production cost models are often used for planning by simulating power system operations over long time horizons. The simulation of a day-ahead energy market can take several weeks to compute. Tractability improvements are often made through model simplifications, such as: reductions in transmission modeling detail, relaxation of commitment variable integrality, reductions in cost modeling detail, etc. One common simplification is to partition the simulation horizon so that weekly or monthly horizons can be simulated in parallel. However, horizon partitions are often executed with overlap periods of arbitrary and sometimes zero length. We calculate the time domain persistence of historical unit commitment decisions to inform time domain partitioning of production cost models. The results are implemented using PLEXOS production cost modeling software in an HPC environment to improve the computation time of simulations while maintaining solution integrity.

  7. Identification of the glutaminase genes of Aspergillus sojae involved in glutamate production during soy sauce fermentation.

    Science.gov (United States)

    Ito, Kotaro; Koyama, Yasuji; Hanya, Yoshiki

    2013-01-01

    Glutaminase, an enzyme that catalyzes the conversion of L-glutamine to L-glutamate, enhances the umami taste in soy sauce. The Aspergillus sojae genome contains 10 glutaminase genes. In this study, we estimated that approximately 60% of the glutamate in soy sauce is produced through the glutaminase reaction. To determine which glutaminase is involved in soy sauce glutamate production, we prepared soy sauces using single and multiple glutaminase gene disruptants of A. sojae. The glutamate concentration in soy sauce prepared using the ΔgahA-ΔgahB-ΔggtA-Δgls disruptant was approximately 60% lower than that in the control strain, whereas it was decreased by approximately 20-30% in the ΔgahA-ΔgahB disruptant. However, the glutamate concentration was unchanged in the soy sauces prepared using the ΔgahA-ΔggtA-Δgls and ΔgahB-ΔggtA-Δgls disruptants. These results indicate that four glutaminases are involved in glutamate production in soy sauce, and that the peptidoglutaminase activities of GahA and GahB increase the glutamate concentration in soy sauce.

  8. Evidence for the involvement of 5-lipoxygenase products in ethanol-induced intestinal plasma protein loss

    International Nuclear Information System (INIS)

    Beck, I.T.; Boyd, A.J.; Dinda, P.K.

    1988-01-01

    In this study the authors investigated whether the products of 5-lipoxygenase (5-LO) were involved in the jejunal microvascular injury induced by intraluminal ethanol (ETH). A group of rabbits was given orally a selective inhibitor of 5-LO in two 10-mg doses, 24, and 2 h before the experiments. A jejunal segment was perfused with a control solution (control segment) and an adjacent segment with an ETH-containing solution (ETH-perfused segment). In a series of experiments, they measured 5-LO activity of the jejunal segments of both groups using the generation of leukotriene B 4 (LTB 4 ) as an index. In a second series of experiments, they determined the ETH-induced intraluminal protein loss, which was taken as a measure of mucosal microvascular damage. The ETH-induced increase in protein loss was significantly lower in the treated than in the untreated group. These findings suggest that products of 5-LO are involved in the ETH-induced jejunal microvascular injury

  9. Bifurcation and complex dynamics of a discrete-time predator-prey system involving group defense

    Directory of Open Access Journals (Sweden)

    S. M. Sohel Rana

    2015-09-01

    Full Text Available In this paper, we investigate the dynamics of a discrete-time predator-prey system involving group defense. The existence and local stability of positive fixed point of the discrete dynamical system is analyzed algebraically. It is shown that the system undergoes a flip bifurcation and a Neimark-Sacker bifurcation in the interior of R+2 by using bifurcation theory. Numerical simulation results not only show the consistence with the theoretical analysis but also display the new and interesting dynamical behaviors, including phase portraits, period-7, 20-orbits, attracting invariant circle, cascade of period-doubling bifurcation from period-20 leading to chaos, quasi-periodic orbits, and sudden disappearance of the chaotic dynamics and attracting chaotic set. The Lyapunov exponents are numerically computed to characterize the complexity of the dynamical behaviors.

  10. Discrete-Time Filter Synthesis using Product of Gegenbauer Polynomials

    OpenAIRE

    N. Stojanovic; N. Stamenkovic; I. Krstic

    2016-01-01

    A new approximation to design continuoustime and discrete-time low-pass filters, presented in this paper, based on the product of Gegenbauer polynomials, provides the ability of more flexible adjustment of passband and stopband responses. The design is achieved taking into account a prescribed specification, leading to a better trade-off among the magnitude and group delay responses. Many well-known continuous-time and discrete-time transitional filter based on the classical polynomial approx...

  11. The proteins of Fusobacterium spp. involved in hydrogen sulfide production from L-cysteine.

    Science.gov (United States)

    Basic, Amina; Blomqvist, Madeleine; Dahlén, Gunnar; Svensäter, Gunnel

    2017-03-14

    Hydrogen sulfide (H 2 S) is a toxic foul-smelling gas produced by subgingival biofilms in patients with periodontal disease and is suggested to be part of the pathogenesis of the disease. We studied the H 2 S-producing protein expression of bacterial strains associated with periodontal disease. Further, we examined the effect of a cysteine-rich growth environment on the synthesis of intracellular enzymes in F. nucleatum polymorphum ATCC 10953. The proteins were subjected to one-dimensional (1DE) and two-dimensional (2DE) gel electrophoresis An in-gel activity assay was used to detect the H 2 S-producing enzymes; Sulfide from H 2 S, produced by the enzymes in the gel, reacted with bismuth forming bismuth sulfide, illustrated as brown bands (1D) or spots (2D) in the gel. The discovered proteins were identified with liquid chromatography - tandem mass spectrometry (LC-MS/MS). Cysteine synthase and proteins involved in the production of the coenzyme pyridoxal 5'phosphate (that catalyzes the production of H 2 S) were frequently found among the discovered enzymes. Interestingly, a higher expression of H 2 S-producing enzymes was detected from bacteria incubated without cysteine prior to the experiment. Numerous enzymes, identified as cysteine synthase, were involved in the production of H 2 S from cysteine and the expression varied among Fusobacterium spp. and strains. No enzymes were detected with the in-gel activity assay among the other periodontitis-associated bacteria tested. The expression of the H 2 S-producing enzymes was dependent on environmental conditions such as cysteine concentration and pH but less dependent on the presence of serum and hemin.

  12. Highly reconfigurable production systems controlled by real-time agents

    OpenAIRE

    Schütz, D.;Schraufstetter, M.;Folmer, J.;Vogel-Heuser, B.;Gmeiner, T.;Shea, K.

    2017-01-01

    Flexible plant components can significantly increase the flexibility of manufacturing systems and enable concepts like mass-customized production. This paper presents an approach for production planning and execution for flexible manufacturing system components, based on software agents. The agents are implemented directly on a PLC, making them capable of real-time operation. Additionally, a service-interface contributes to the vertical integration of the approach into the higher level planni...

  13. Goods-Time Elasticity of Substitution in Health Production.

    Science.gov (United States)

    Du, Juan; Yagihashi, Takeshi

    2017-11-01

    We examine how inputs for health production, in particular, medical care and health-enhancing time, are combined to improve health. The estimated elasticity of substitution from a constant elasticity of substitution production function is significantly less than one for the working-age population, rejecting the unit elasticity of substitution used in previous studies. Copyright © 2016 John Wiley & Sons, Ltd. Copyright © 2016 John Wiley & Sons, Ltd.

  14. A stochastic surplus production model in continuous time

    DEFF Research Database (Denmark)

    Pedersen, Martin Wæver; Berg, Casper Willestofte

    2017-01-01

    surplus production model in continuous time (SPiCT), which in addition to stock dynamics also models the dynamics of the fisheries. This enables error in the catch process to be reflected in the uncertainty of estimated model parameters and management quantities. Benefits of the continuous-time state......Surplus production modelling has a long history as a method for managing data-limited fish stocks. Recent advancements have cast surplus production models as state-space models that separate random variability of stock dynamics from error in observed indices of biomass. We present a stochastic......-space model formulation include the ability to provide estimates of exploitable biomass and fishing mortality at any point in time from data sampled at arbitrary and possibly irregular intervals. We show in a simulation that the ability to analyse subannual data can increase the effective sample size...

  15. Timing of product introduction in network economies under heterogeneous demand

    DEFF Research Database (Denmark)

    Winther, Christian Dahl

    This paper studies the introduction of a new and incompatible technology in a spatial market with network externalities. In competition with an established network, the entrant chooses how long to do research and a level of product differentiation, which determine the adoption patterns of consumers...... level of product differentiation that should be chosen by the sponsor of the new technology in equilibrium. Third, the formal relationship between these variables are derived under compatibility.  Fourth, the entering firm's problem is solved by numerical methods to gain insight into the optimal linkage...... between research time and product design....

  16. An Evolutionary Genomic Approach to Identify Genes Involved in Human Birth Timing

    Science.gov (United States)

    Orabona, Guilherme; Morgan, Thomas; Haataja, Ritva; Hallman, Mikko; Puttonen, Hilkka; Menon, Ramkumar; Kuczynski, Edward; Norwitz, Errol; Snegovskikh, Victoria; Palotie, Aarno; Fellman, Vineta; DeFranco, Emily A.; Chaudhari, Bimal P.; McGregor, Tracy L.; McElroy, Jude J.; Oetjens, Matthew T.; Teramo, Kari; Borecki, Ingrid; Fay, Justin; Muglia, Louis

    2011-01-01

    Coordination of fetal maturation with birth timing is essential for mammalian reproduction. In humans, preterm birth is a disorder of profound global health significance. The signals initiating parturition in humans have remained elusive, due to divergence in physiological mechanisms between humans and model organisms typically studied. Because of relatively large human head size and narrow birth canal cross-sectional area compared to other primates, we hypothesized that genes involved in parturition would display accelerated evolution along the human and/or higher primate phylogenetic lineages to decrease the length of gestation and promote delivery of a smaller fetus that transits the birth canal more readily. Further, we tested whether current variation in such accelerated genes contributes to preterm birth risk. Evidence from allometric scaling of gestational age suggests human gestation has been shortened relative to other primates. Consistent with our hypothesis, many genes involved in reproduction show human acceleration in their coding or adjacent noncoding regions. We screened >8,400 SNPs in 150 human accelerated genes in 165 Finnish preterm and 163 control mothers for association with preterm birth. In this cohort, the most significant association was in FSHR, and 8 of the 10 most significant SNPs were in this gene. Further evidence for association of a linkage disequilibrium block of SNPs in FSHR, rs11686474, rs11680730, rs12473870, and rs1247381 was found in African Americans. By considering human acceleration, we identified a novel gene that may be associated with preterm birth, FSHR. We anticipate other human accelerated genes will similarly be associated with preterm birth risk and elucidate essential pathways for human parturition. PMID:21533219

  17. Norm-times : a design for production time and variability reduction for Faes Cases

    NARCIS (Netherlands)

    Karandeinos, Georgios

    2008-01-01

    This project deals with the production process of Faes Cases business unit. This company is producing custom-made packaging and sells standard solutions with customized interior. During the last years, it was observed that the throughput time of the production is increasing and is hard to forecast

  18. An economic production model for time dependent demand with rework and multiple production setups

    Directory of Open Access Journals (Sweden)

    S.R. Singh

    2014-04-01

    Full Text Available In this paper, we present a model for time dependent demand with multiple productions and rework setups. Production is demand dependent and greater than the demand rate. Production facility produces items in m production setups and one rework setup (m, 1 policy. The major reason of reverse logistic and green supply chain is rework, so it reduces the cost of production and other ecological problems. Most of the researchers developed a rework model without deteriorating items. A numerical example and sensitivity analysis is shown to describe the model.

  19. Neural correlates of time versus money in product evaluation

    Directory of Open Access Journals (Sweden)

    Sebastian eLehmann

    2012-10-01

    Full Text Available The common saying time is money reflects the widespread belief in many people’s everyday life that time is valuable like money. Psychologically and neurophysiologically, however, these concepts seem to be quite different. This research replicates prior behavioral investigations by showing that merely mentioning time (compared to merely mentioning money leads participants to evaluate a product more positively. Beyond this finding, the present functional magnetic resonance imaging (fMRI experiment provides novel insight into the neurophysiological underpinnings of this behavioral effect by showing that more positive product evaluations in the time primes (compared to money primes are preceded by increased activation in the insula. Our data, therefore, support the idea of a time mindset that is different from a money mindset. Studies on the functional neuroanatomy of the insula have implicated this brain area in distinct but related psychological phenomena such as urging, addiction, loss aversion, and love. These functions imply greater personal connection between the consumer and a target subject or object and, thus, help explain why time-primed consumers rate products more positively.

  20. Private sector involvement in times of armed conflict: What are the constraints for trading medical equipment?

    Science.gov (United States)

    Schmidt, Georg

    Today, healthcare facilities are highly dependent on the private sector to keep their medical equipment functioning. Moreover, private sector involvement becomes particularly important for the supply of spare parts and consumables. However, in times of armed conflict, the capacity of the corporate world appears to be seriously hindered. Subsequently, this study researches the influence of armed conflict on the private medical equipment sector. This study follows a qualitative approach by conducting 19 interviews with representatives of the corporate world in an active conflict zone. A semistructured interview guide, consisting of 10 questions, was used to examine the constraints of this sector. The results reveal that the lack of skilled personnel, complicated importation procedures, and a decrease in financial capacity are the major constraints faced by private companies dealing in medical equipment in conflict zones. Even when no official sanctions and embargoes for medical items exist, constraints for trading medical equipment are clearly recognizable. Countries at war would benefit from a centralized structure that deals with the importation procedures for medical items, to assist local companies in their purchasing procedures. A high degree of adaption is needed to continue operating, despite the emerging constraints of armed conflict. Future studies might research the constraints for manufacturers outside the conflict to export medical items to the country of war.

  1. Yeast genes involved in regulating cysteine uptake affect production of hydrogen sulfide from cysteine during fermentation.

    Science.gov (United States)

    Huang, Chien-Wei; Walker, Michelle E; Fedrizzi, Bruno; Gardner, Richard C; Jiranek, Vladimir

    2017-08-01

    An early burst of hydrogen sulfide (H2S) produced by Saccharomyces cerevisiae during fermentation could increase varietal thiols and therefore enhance desirable tropical aromas in varieties such as Sauvignon Blanc. Here we attempted to identify genes affecting H2S formation from cysteine by screening yeast deletion libraries via a colony colour assay on media resembling grape juice. Both Δlst4 and Δlst7 formed lighter coloured colonies and produced significantly less H2S than the wild type on high concentrations of cysteine, likely because they are unable to take up cysteine efficiently. We then examined the nine known cysteine permeases and found that deletion of AGP1, GNP1 and MUP1 led to reduced production of H2S from cysteine. We further showed that deleting genes involved in the SPS-sensing pathway such as STP1 and DAL81 also reduced H2S from cysteine. Together, this study indirectly confirms that Agp1p, Gnp1p and Mup1p are the major cysteine permeases and that they are regulated by the SPS-sensing and target of rapamycin pathways under the grape juice-like, cysteine-supplemented, fermentation conditions. The findings highlight that cysteine transportation could be a limiting factor for yeast to generate H2S from cysteine, and therefore selecting wine yeasts without defects in cysteine uptake could maximise thiol production potential. © FEMS 2017. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  2. The peak of oil production-Timings and market recognition

    International Nuclear Information System (INIS)

    Almeida, Pedro de; Silva, Pedro D.

    2009-01-01

    Energy is essential for present societies. In particular, transportation systems depend on petroleum-based fuels. That world oil production is set to pass a peak is now a reasonably accepted concept, although its date is far from consensual. In this work, we analyze the true expectations of the oil market participants about the future availability of this fundamental energy source. We study the evolution through time of the curves of crude oil futures prices, and we conclude that the market participants, among them the crude oil producers, already expect a near-term peak of oil production. This agrees with many technical predictions for the date of peak production, including our own, that point to peak dates around the end of the present decade. If this scenario is confirmed, it can cause serious social and economical problems because societies will have little time to perform the necessary adjustments

  3. Effect of Retention Time on Biogas Production from Poultry ...

    African Journals Online (AJOL)

    JPC

    Daily gas production fell slightly from 130 to 32 litres as retention time was ... The continuing energy crisis has reawakened interest in the anaerobic ... and hydrogen sulfide (H2S2): 0.3 vol.%. ..... Nigerian Journal of Solar Energy 15: 80 – 85.

  4. The Times Higher Education Ranking Product: Visualising Excellence through Media

    Science.gov (United States)

    Stack, Michelle L.

    2013-01-01

    This paper will examine the Times Higher Education's (THE) World University Rankings as a corporate media product. A number of empirical studies have critiqued the methodology of the THE, yet individuals, Higher Education Institutions (HEIs) and governments continue to use them for decision-making. This paper analyses the influence of…

  5. The Triggers, Timing and Speed of New Product Price Landings

    NARCIS (Netherlands)

    C. Hernández-Mireles (Carlos); D. Fok (Dennis); Ph.H.B.F. Franses (Philip Hans)

    2008-01-01

    textabstractMany high-tech products and durable goods exhibit exactly one significant price cut some time after their launch. We call this sudden transition from high to low prices the price landing. In this paper we present a new model that describes two important features of price landings: their

  6. Designing life-time recycling loops for elastomer products

    NARCIS (Netherlands)

    Noordermeer, Jacques; Dierkes, Wilma; Blume, Anke; Dijkhuis, Kuno; van Hoek, Hans; Reuvekamp, Louis; Saiwari, Siti

    2017-01-01

    With depletion of natural resources and growing awareness of the limited capabilities of the globe to cope with pollution, the need to design life-time recycling loops for all types of products is steadily increasing. Rubber articles of all sorts and the need for a proper disposal of these at the

  7. Real-Time Tropospheric Delay Estimation using IGS Products

    Science.gov (United States)

    Stürze, Andrea; Liu, Sha; Söhne, Wolfgang

    2014-05-01

    The Federal Agency for Cartography and Geodesy (BKG) routinely provides zenith tropospheric delay (ZTD) parameter for the assimilation in numerical weather models since more than 10 years. Up to now the results flowing into the EUREF Permanent Network (EPN) or E-GVAP (EUMETNET EIG GNSS water vapour programme) analysis are based on batch processing of GPS+GLONASS observations in differential network mode. For the recently started COST Action ES1206 about "Advanced Global Navigation Satellite Systems tropospheric products for monitoring severe weather events and climate" (GNSS4SWEC), however, rapid updates in the analysis of the atmospheric state for nowcasting applications require changing the processing strategy towards real-time. In the RTCM SC104 (Radio Technical Commission for Maritime Services, Special Committee 104) a format combining the advantages of Precise Point Positioning (PPP) and Real-Time Kinematic (RTK) is under development. The so-called State Space Representation approach is defining corrections, which will be transferred in real-time to the user e.g. via NTRIP (Network Transport of RTCM via Internet Protocol). Meanwhile messages for precise orbits, satellite clocks and code biases compatible to the basic PPP mode using IGS products are defined. Consequently, the IGS Real-Time Service (RTS) was launched in 2013 in order to extend the well-known precise orbit and clock products by a real-time component. Further messages e.g. with respect to ionosphere or phase biases are foreseen. Depending on the level of refinement, so different accuracies up to the RTK level shall be reachable. In co-operation of BKG and the Technical University of Darmstadt the real-time software GEMon (GREF EUREF Monitoring) is under development. GEMon is able to process GPS and GLONASS observation and RTS product data streams in PPP mode. Furthermore, several state-of-the-art troposphere models, for example based on numerical weather prediction data, are implemented. Hence, it

  8. The Influence of Brand Associations on Brand Loyalty in Accordance with Product Involvement

    Directory of Open Access Journals (Sweden)

    Canan Eryigit

    2013-01-01

    Full Text Available The purpose of this study is to examine whether the influence of brand associations on brand loyalty differ for high involved and low involved consumers. The study is conducted on the followers of professional football teams. The results of the Chow test revealed that influence of brand associations on brand loyalty differ for high involved and low involved consumers. The affects of attributes are greater for high involved consumers rather than low involved consumers. The affect of brand attitude is greater for low involved consumers rather than low involved consumers.

  9. Discrete-Time Filter Synthesis using Product of Gegenbauer Polynomials

    Directory of Open Access Journals (Sweden)

    N. Stojanovic

    2016-09-01

    Full Text Available A new approximation to design continuoustime and discrete-time low-pass filters, presented in this paper, based on the product of Gegenbauer polynomials, provides the ability of more flexible adjustment of passband and stopband responses. The design is achieved taking into account a prescribed specification, leading to a better trade-off among the magnitude and group delay responses. Many well-known continuous-time and discrete-time transitional filter based on the classical polynomial approximations(Chebyshev, Legendre, Butterworth are shown to be a special cases of proposed approximation method.

  10. Analysis of labor employment assessment on production machine to minimize time production

    Science.gov (United States)

    Hernawati, Tri; Suliawati; Sari Gumay, Vita

    2018-03-01

    Every company both in the field of service and manufacturing always trying to pass efficiency of it’s resource use. One resource that has an important role is labor. Labor has different efficiency levels for different jobs anyway. Problems related to the optimal allocation of labor that has different levels of efficiency for different jobs are called assignment problems, which is a special case of linear programming. In this research, Analysis of Labor Employment Assesment on Production Machine to Minimize Time Production, in PT PDM is done by using Hungarian algorithm. The aim of the research is to get the assignment of optimal labor on production machine to minimize time production. The results showed that the assignment of existing labor is not suitable because the time of completion of the assignment is longer than the assignment by using the Hungarian algorithm. By applying the Hungarian algorithm obtained time savings of 16%.

  11. Time-ordered product expansions for computational stochastic system biology

    International Nuclear Information System (INIS)

    Mjolsness, Eric

    2013-01-01

    The time-ordered product framework of quantum field theory can also be used to understand salient phenomena in stochastic biochemical networks. It is used here to derive Gillespie’s stochastic simulation algorithm (SSA) for chemical reaction networks; consequently, the SSA can be interpreted in terms of Feynman diagrams. It is also used here to derive other, more general simulation and parameter-learning algorithms including simulation algorithms for networks of stochastic reaction-like processes operating on parameterized objects, and also hybrid stochastic reaction/differential equation models in which systems of ordinary differential equations evolve the parameters of objects that can also undergo stochastic reactions. Thus, the time-ordered product expansion can be used systematically to derive simulation and parameter-fitting algorithms for stochastic systems. (paper)

  12. Modality effects in Second Life: the mediating role of social presence and the moderating role of product involvement.

    Science.gov (United States)

    Jin, Seung-A Annie

    2009-12-01

    The rapid growth of virtual worlds is one of the most recent Internet trends. Some distinguishing features of virtual environments include the employment of avatars and multimodal communication among avatars. This study examined the effects of the modality (text vs. audio) of message presentation on people's evaluation of spokes-avatar credibility and the informational value of promotional messages in avatar-based advertising inside 3D virtual environments. An experiment was conducted in the virtual Apple retail store inside Second Life, the most popular and fastest growing virtual world. The author designed a two-group (textual advertisement vs. auditory advertisement) comparison experiment by manipulating the modality of conveying advertisement messages. The author also created a spokes-avatar that represents a real-life organization (Apple) and presents promotional messages about its innovative product, the iPhone. Data analyses showed that (a) textual modality (vs. auditory modality) resulted in greater source expertise, informational value of the advertisement message, and social presence; and that (b) high product involvement (vs. low product involvement) resulted in a more positive attitude toward the product, higher buying intention, and a higher level of perceived interactivity. In addition to the main effects of product involvement and modality, results showed significant interaction between involvement and modality. Modality effects were stronger for people with low product involvement than for those with high product involvement, thus confirming the moderating effects of product involvement. Results of a path analysis also showed that social presence mediated the effects of modality on the perceived informational value of the advertisement message.

  13. Evaluation of cochlear involvement by distortion product otoacoustic emission in Behçet's disease.

    Science.gov (United States)

    Dagli, Muharrem; Eryilmaz, Adil; Tanrikulu, Salih; Aydin, Acar; Gonul, Muzeyyen; Gul, Ulker; Gocer, Celil

    2008-09-01

    The aim of this study was to investigate cochlear involvement in patients with Behçet's disease. Twenty-six Behçet's disease patients (52 ears) and 24 sex and age-matched healthy control subjects (48 ears) were included in the study. Pure-tone audiometry at frequencies 250, 500, 1000, 2000, 4000, 6000 Hz, immittance measures including tympanometry and acoustic reflex testing and DPOAE (distortion product otoacoustic emission) testing were performed in the patients and controls. A sensorineural hearing loss was found in eight patients (30.7%) as it was bilateral in five and unilateral in three patients. Although no typical audiometric configuration was found, one patient had a flat type audiogram, and the others had a high frequency hearing loss. The DPOAE responses of the patients and controls were significantly different in all frequencies (p<0.05). These results indicate that cochlea is affected by damage of outer hair cells in Behçet's disease.

  14. COUNTRY OF ORIGIN, BRAND IMAGE AND HIGH INVOLVEMENT PRODUCT TOWARDS CUSTOMER PURCHASE INTENTION: EMPIRICAL EVIDENCE OF EAST MALAYSIAN CONSUMER

    Directory of Open Access Journals (Sweden)

    Mohd Amirul Adenan

    2018-03-01

    Full Text Available This research strives to understand East Malaysian consumers’ purchase intention when being exposed to the effects of brand image and country of origin (COO image in the case of high involvement pro­ducts. Self-administered questionnaires were collected from 225 consumers in East Malaysia. The result of this study shows that East Malaysian consumers’ put a large importance on brand and country of origin image in high involvement products as they are more involved in information searching and decision ma­king when purchases these products. Implication and future research also discussed.

  15. Improving wheat productivity through source and timing of nitrogen fertilization

    International Nuclear Information System (INIS)

    Jan, M.T.; Khan, A.; Afridi, M.Z.; Arif, M.; Khan, M.J.; Farhatullah; Jan, D.; Saeed, M.

    2011-01-01

    Efficient nitrogen (N) fertilizer management is critical for the improved production of wheat (Triticum aestivum L.) and can be achieved through source and timing of N application. Thus, an experiment was carried out at the Research Farm of KPK Agricultural University Peshawar during 2005-06 to test the effects of sources and timing of N application on yield and yield components of wheat. Nitrogen sources were ammonium (NH/sub 4/) and nitrate (NO/sub 3/) applied at the rate of 100 kg ha/sup -1/ at three different stages i.e., at sowing (S1), tillering (S2) and boot stage (S3). Ammonium N increased yield component but did not affect the final grain yield. Split N application at sowing, tillering and boot stages had increased productive tillers m-2, and thousand grains weight, whereas grain yield was higher when N was applied at tillering and boot stages. Nitrogen fertilization increased 20% grain yield compared to control regardless of N application time. It was concluded from the experiment that split application of NH/sub 4/-N performed better than full dose application and/or NO/sub 3/-N for improved wheat productivity and thus, is recommended for general practice in agro-climatic conditions of Peshawar. (author)

  16. Stake holder involvement in the Canadian review process for uranium production projects in Northern Saskatchewan

    International Nuclear Information System (INIS)

    Underhill, D.

    2004-01-01

    This report describes the Canadian environmental review process for uranium production projects as a case study for the purpose of understanding the nature and value of stakeholder involvement in the management of radiological hazards. While the Canadian review process potentially applies to any development, this case study focuses on the assessment of the uranium projects of northern Saskatchewan conducted during the 1990's. It describes the environmental assessment (EA) conducted in the 1990's for six new uranium facilities (including mines and mills and related tailings disposal sites) planned in northern Saskatchewan. Both the Canadian federal and the Saskatchewan provincial government have extensive environmental review processes that must under law be complete before any major industrial development judged to have potential environmental impacts is undertaken within their respective territories. However, even in those instances where no clear potential environmental impacts are evident, Canadian law mandates 'if public concern about the proposal is such that a public review is desirable, the initiating department shall refer the proposal to the Minister for review by a Panel'. (Wh95) As a stakeholder under law, in both Canada and Saskatchewan, the public plays an important role in the environmental review process. To encourage participation and assist the public in its review the two governments may provide funding (as done in this review) to assist qualified individuals or groups to participant in the review process. The first section of this case study sets the scene. It describes the Saskatchewan uranium mining story, focusing on how the importance of the public stakeholder evolved to become a major component, under law, in the EA process for new uranium mines. This increase in stakeholder involvement opportunities coincided with heightened public concern for the socio-economic impacts of the projects. In the late 1980's both governments were advised by

  17. Antecedents and effects of consumer involvement in fish as a product group

    DEFF Research Database (Denmark)

    Juhl, Hans Jørn; Poulsen, Carsten Stig

    2000-01-01

    important to marketing strategies. However, the potential effects of involvement did not differ between the segments. Rather, the customer's involvement ensures that sign value and utility have effects such as greater enjoyment of shopping and higher frequency of usage....

  18. Supplier's involvement and success of radical new product development in new ventures

    NARCIS (Netherlands)

    Song, Michael; Di Benedetto, Anthony

    2008-01-01

    Supplier involvement is essential to a new venture seeking to develop a radical innovation. Despite this, prior literature has not adequately addressed supplier involvement in radical innovation, nor what the antecedents to increased supplier involvement are. We build and test a conceptual model of

  19. Fluoroscopically guided transforaminal epidural steroid injections at a quaternary-care teaching institution: effect of trainee involvement and patient body mass index on fluoroscopy time and patient dose

    International Nuclear Information System (INIS)

    Tiegs-Heiden, C.A.; Murthy, N.S.; Geske, J.R.; Diehn, F.E.; Schueler, B.A.; Wald, J.T.; Kaufmann, T.J.; Lehman, V.T.; Carr, C.M.; Amrami, K.K.; Morris, J.M.; Thielen, K.R.; Maus, T.P.

    2016-01-01

    Aim: To investigate whether there are differences in fluoroscopy time and patient dose for fluoroscopically guided lumbar transforaminal epidural steroid injections (TFESIs) performed by staff radiologists versus with trainees and to evaluate the effect of patient body mass index (BMI) on fluoroscopy time and patient dose, including their interactions with other variables. Materials and methods: Single-level lumbar TFESIs (n=1844) between 1 January 2011 and 31 December 2013 were reviewed. Fluoroscopy time, reference point air kerma (K_a_,_r), and kerma area product (KAP) were recorded. BMI and trainee involvement were examined as predictors of fluoroscopy time, K_a_,_r, and KAP in models adjusted for age and gender in multivariable linear models. Stratified models of BMI groups by trainee presence were performed. Results: Increased age was the only significant predictor of increased fluoroscopy time (p<0.0001). K_a_,_r and KAP were significantly higher in patients with a higher BMI (p<0.0001 and p=0.0009). When stratified by BMI, longer fluoroscopy time predicted increased K_a_,_r and KAP in all groups (p<0.0001). Trainee involvement was not a statistically significant predictor of fluoroscopy time or K_a_,_r in any BMI category. KAP was lower with trainees in the overweight group (p=0.0009) and higher in male patients for all BMI categories (p<0.02). Conclusion: Trainee involvement did not result in increased fluoroscopy time or patient dose. BMI did not affect fluoroscopy time; however, overweight and obese patients received significantly higher K_a_,_r and KAP. Male patients received a higher KAP in all BMI categories. Limiting fluoroscopy time and good collimation practices should be reinforced in these patients. - Highlights: • Trainee involvement did not contribute to increased fluoroscopy time or dose. • BMI did not affect fluoroscopy time. • Overweight and obese patients received significantly higher Ka,r and KAP.

  20. Job Involvement of Part-Time Faculty: Exploring Associations with Distributive Justice, Underemployment, Work Status Congruence, and Empowerment

    Science.gov (United States)

    Seo, Jae Young

    2013-01-01

    For decades, higher education institutions have been increasingly reliant upon part-time faculty. As the role of part-time faculty in colleges and universities has evolved and gained prominence, it is increasingly important to gain a deeper understanding of their perceptions of job involvement considered as potential predictor of turnover and…

  1. Public involvement in the priority setting activities of a wait time management initiative: a qualitative case study.

    Science.gov (United States)

    Bruni, Rebecca A; Laupacis, Andreas; Levinson, Wendy; Martin, Douglas K

    2007-11-16

    As no health system can afford to provide all possible services and treatments for the people it serves, each system must set priorities. Priority setting decision makers are increasingly involving the public in policy making. This study focuses on public engagement in a key priority setting context that plagues every health system around the world: wait list management. The purpose of this study is to describe and evaluate priority setting for the Ontario Wait Time Strategy, with special attention to public engagement. This study was conducted at the Ontario Wait Time Strategy in Ontario, Canada which is part of a Federal-Territorial-Provincial initiative to improve access and reduce wait times in five areas: cancer, cardiac, sight restoration, joint replacements, and diagnostic imaging. There were two sources of data: (1) over 25 documents (e.g. strategic planning reports, public updates), and (2) 28 one-on-one interviews with informants (e.g. OWTS participants, MOHLTC representatives, clinicians, patient advocates). Analysis used a modified thematic technique in three phases: open coding, axial coding, and evaluation. The Ontario Wait Time Strategy partially meets the four conditions of 'accountability for reasonableness'. The public was not directly involved in the priority setting activities of the Ontario Wait Time Strategy. Study participants identified both benefits (supporting the initiative, experts of the lived experience, a publicly funded system and sustainability of the healthcare system) and concerns (personal biases, lack of interest to be involved, time constraints, and level of technicality) for public involvement in the Ontario Wait Time Strategy. Additionally, the participants identified concern for the consequences (sustainability, cannibalism, and a class system) resulting from the Ontario Wait Times Strategy. We described and evaluated a wait time management initiative (the Ontario Wait Time Strategy) with special attention to public

  2. Public involvement in the priority setting activities of a wait time management initiative: a qualitative case study

    Directory of Open Access Journals (Sweden)

    Laupacis Andreas

    2007-11-01

    Full Text Available Abstract Background As no health system can afford to provide all possible services and treatments for the people it serves, each system must set priorities. Priority setting decision makers are increasingly involving the public in policy making. This study focuses on public engagement in a key priority setting context that plagues every health system around the world: wait list management. The purpose of this study is to describe and evaluate priority setting for the Ontario Wait Time Strategy, with special attention to public engagement. Methods This study was conducted at the Ontario Wait Time Strategy in Ontario, Canada which is part of a Federal-Territorial-Provincial initiative to improve access and reduce wait times in five areas: cancer, cardiac, sight restoration, joint replacements, and diagnostic imaging. There were two sources of data: (1 over 25 documents (e.g. strategic planning reports, public updates, and (2 28 one-on-one interviews with informants (e.g. OWTS participants, MOHLTC representatives, clinicians, patient advocates. Analysis used a modified thematic technique in three phases: open coding, axial coding, and evaluation. Results The Ontario Wait Time Strategy partially meets the four conditions of 'accountability for reasonableness'. The public was not directly involved in the priority setting activities of the Ontario Wait Time Strategy. Study participants identified both benefits (supporting the initiative, experts of the lived experience, a publicly funded system and sustainability of the healthcare system and concerns (personal biases, lack of interest to be involved, time constraints, and level of technicality for public involvement in the Ontario Wait Time Strategy. Additionally, the participants identified concern for the consequences (sustainability, cannibalism, and a class system resulting from the Ontario Wait Times Strategy. Conclusion We described and evaluated a wait time management initiative (the Ontario

  3. Consumer input into health care: Time for a new active and comprehensive model of consumer involvement.

    Science.gov (United States)

    Hall, Alix E; Bryant, Jamie; Sanson-Fisher, Rob W; Fradgley, Elizabeth A; Proietto, Anthony M; Roos, Ian

    2018-03-07

    To ensure the provision of patient-centred health care, it is essential that consumers are actively involved in the process of determining and implementing health-care quality improvements. However, common strategies used to involve consumers in quality improvements, such as consumer membership on committees and collection of patient feedback via surveys, are ineffective and have a number of limitations, including: limited representativeness; tokenism; a lack of reliable and valid patient feedback data; infrequent assessment of patient feedback; delays in acquiring feedback; and how collected feedback is used to drive health-care improvements. We propose a new active model of consumer engagement that aims to overcome these limitations. This model involves the following: (i) the development of a new measure of consumer perceptions; (ii) low cost and frequent electronic data collection of patient views of quality improvements; (iii) efficient feedback to the health-care decision makers; and (iv) active involvement of consumers that fosters power to influence health system changes. © 2018 The Authors Health Expectations published by John Wiley & Sons Ltd.

  4. Real time information management for improving productivity in metallurgical complexes

    International Nuclear Information System (INIS)

    Bascur, O.A.; Kennedy, J.P.

    1999-01-01

    Applying the latest information technologies in industrial plants has become a serious challenge to management and technical teams. The availability of real time and historical operations information to identify the most critical part of the processing system from mechanical integrity is a must for global plant optimization. Expanded use of plant information on the desktop is a standard tool for revenue improvement, cost reduction, and adherence to production constraints. The industrial component desktop supports access to information for process troubleshooting, continuous improvement and innovation by plant and staff personnel. Collaboration between groups enables the implementation of an overall process effectiveness index based on losses due to equipment availability, production and product quality. The key to designing technology is to use the Internet based technologies created by Microsoft for its marketplace-office automation and the Web. Time derived variables are used for process analysis, troubleshooting and performance assessment. Connectivity between metallurgical complexes, research centers and their business system has become a reality. Two case studies of large integrated mining/metallurgical complexes are highlighted. (author)

  5. Time series analysis of gold production in Malaysia

    Science.gov (United States)

    Muda, Nora; Hoon, Lee Yuen

    2012-05-01

    Gold is a soft, malleable, bright yellow metallic element and unaffected by air or most reagents. It is highly valued as an asset or investment commodity and is extensively used in jewellery, industrial application, dentistry and medical applications. In Malaysia, gold mining is limited in several areas such as Pahang, Kelantan, Terengganu, Johor and Sarawak. The main purpose of this case study is to obtain a suitable model for the production of gold in Malaysia. The model can also be used to predict the data of Malaysia's gold production in the future. Box-Jenkins time series method was used to perform time series analysis with the following steps: identification, estimation, diagnostic checking and forecasting. In addition, the accuracy of prediction is tested using mean absolute percentage error (MAPE). From the analysis, the ARIMA (3,1,1) model was found to be the best fitted model with MAPE equals to 3.704%, indicating the prediction is very accurate. Hence, this model can be used for forecasting. This study is expected to help the private and public sectors to understand the gold production scenario and later plan the gold mining activities in Malaysia.

  6. TIME MANAGEMENT AND ITS IMPLEMENTATION AT PRODUCTION COMPANIES

    Directory of Open Access Journals (Sweden)

    Yurii Safonov

    2017-11-01

    Full Text Available The purpose and objectives. Time management is still not a very popular element in many enterprises, while its implementation significantly increases staff productivity and, ultimately, the effectiveness of the company. For this reason, the purpose of the article is to promote time management in a business environment by providing specific tools, principles, methods and systems, and to show its importance to the company and describe the influence of time management for the enterprise. Methods. The study used a generalization, systematization, empirical research, systematic and logical approach to the development of theoretical and methodological provisions for instrumental support management performance of the industrial enterprise. Results. Time management is one of the most important strategic tools of the modern manager. It can help both existing companies and companies that are just launched (the project. Practical implications. The current goal of time management as a mechanism to improve the efficiency of the company. Value/originality. To implement it, the company offered a popular time management system, allowing the company to increase the effectiveness of its activities.

  7. Reducing the throughput time of the diagnostic track involving CT scanning with computer simulation

    International Nuclear Information System (INIS)

    Lent, Wineke A.M. van; Deetman, Joost W.; Teertstra, H. Jelle; Muller, Sara H.; Hans, Erwin W.; Harten, Wim H. van

    2012-01-01

    Introduction: To examine the use of computer simulation to reduce the time between the CT request and the consult in which the CT report is discussed (diagnostic track) while restricting idle time and overtime. Methods: After a pre implementation analysis in our case study hospital, by computer simulation three scenarios were evaluated on access time, overtime and idle time of the CT; after implementation these same aspects were evaluated again. Effects on throughput time were measured for outpatient short-term and urgent requests only. Conclusion: The pre implementation analysis showed an average CT access time of 9.8 operating days and an average diagnostic track of 14.5 operating days. Based on the outcomes of the simulation, management changed the capacity for the different patient groups to facilitate a diagnostic track of 10 operating days, with a CT access time of 7 days. After the implementation of changes, the average diagnostic track duration was 12.6 days with an average CT access time of 7.3 days. The fraction of patients with a total throughput time within 10 days increased from 29% to 44% while the utilization remained equal with 82%, the idle time increased by 11% and the overtime decreased by 82%. The fraction of patients that completed the diagnostic track within 10 days improved with 52%. Computer simulation proved useful for studying the effects of proposed scenarios in radiology management. Besides the tangible effects, the simulation increased the awareness that optimizing capacity allocation can reduce access times.

  8. Reducing the throughput time of the diagnostic track involving CT scanning with computer simulation

    Energy Technology Data Exchange (ETDEWEB)

    Lent, Wineke A.M. van, E-mail: w.v.lent@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); University of Twente, IGS Institute for Innovation and Governance Studies, Department of Health Technology Services Research (HTSR), Enschede (Netherlands); Deetman, Joost W., E-mail: j.deetman@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); Teertstra, H. Jelle, E-mail: h.teertstra@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); Muller, Sara H., E-mail: s.muller@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); Hans, Erwin W., E-mail: e.w.hans@utwente.nl [University of Twente, School of Management and Governance, Dept. of Industrial Engineering and Business Intelligence Systems, Enschede (Netherlands); Harten, Wim H. van, E-mail: w.v.harten@nki.nl [Netherlands Cancer Institute - Antoni van Leeuwenhoek Hospital (NKI-AVL), P.O. Box 90203, 1006 BE Amsterdam (Netherlands); University of Twente, IGS Institute for Innovation and Governance Studies, Department of Health Technology Services Research (HTSR), Enschede (Netherlands)

    2012-11-15

    Introduction: To examine the use of computer simulation to reduce the time between the CT request and the consult in which the CT report is discussed (diagnostic track) while restricting idle time and overtime. Methods: After a pre implementation analysis in our case study hospital, by computer simulation three scenarios were evaluated on access time, overtime and idle time of the CT; after implementation these same aspects were evaluated again. Effects on throughput time were measured for outpatient short-term and urgent requests only. Conclusion: The pre implementation analysis showed an average CT access time of 9.8 operating days and an average diagnostic track of 14.5 operating days. Based on the outcomes of the simulation, management changed the capacity for the different patient groups to facilitate a diagnostic track of 10 operating days, with a CT access time of 7 days. After the implementation of changes, the average diagnostic track duration was 12.6 days with an average CT access time of 7.3 days. The fraction of patients with a total throughput time within 10 days increased from 29% to 44% while the utilization remained equal with 82%, the idle time increased by 11% and the overtime decreased by 82%. The fraction of patients that completed the diagnostic track within 10 days improved with 52%. Computer simulation proved useful for studying the effects of proposed scenarios in radiology management. Besides the tangible effects, the simulation increased the awareness that optimizing capacity allocation can reduce access times.

  9. Role of Weed Emergence Time for the Relative Seed Production in Maize

    Directory of Open Access Journals (Sweden)

    Stefano Benvenuti

    2007-03-01

    Full Text Available Trials were carried out in 2000 and 2001 to investigate the effect of weed emergence time on weed seed production in a maize field. Datura stramonium L., Solanum nigrum L. and Abutilon theophrasti Medicus were selected for their importance as summer weeds. Emergence time was found to be crucial since delay would involve an unfavourable light environment determined by crop canopy elongation and resulting shade production. Only the early emergence of D. stramonium and A. theophrasti showed the capacity to exposing their leaves over the crop canopy. Generally the weed seed production under shade conditions decreased for the reduction of the fruit per plant since the number of seed per plant showed only a light reduction. However, while D. stramonium and A. theophrasti compete with the crop by increasing height, Solanum nigrum tends to adjust to shade without excessive reduction in number of seeds produced. Thus in D. stramonium and A. theophrasti late emergence reduced seed production to only 15%, while S. nigrum maintained 25% of the seed production level generally observed with greater light exposure. This environmental adaptation was confirmed by the less marked decrease in S. nigrum harvest index. Agroecological involvements are discussed.

  10. Role of Weed Emergence Time for the Relative Seed Production in Maize

    Directory of Open Access Journals (Sweden)

    Stefano Benvenuti

    Full Text Available Trials were carried out in 2000 and 2001 to investigate the effect of weed emergence time on weed seed production in a maize field. Datura stramonium L., Solanum nigrum L. and Abutilon theophrasti Medicus were selected for their importance as summer weeds. Emergence time was found to be crucial since delay would involve an unfavourable light environment determined by crop canopy elongation and resulting shade production. Only the early emergence of D. stramonium and A. theophrasti showed the capacity to exposing their leaves over the crop canopy. Generally the weed seed production under shade conditions decreased for the reduction of the fruit per plant since the number of seed per plant showed only a light reduction. However, while D. stramonium and A. theophrasti compete with the crop by increasing height, Solanum nigrum tends to adjust to shade without excessive reduction in number of seeds produced. Thus in D. stramonium and A. theophrasti late emergence reduced seed production to only 15%, while S. nigrum maintained 25% of the seed production level generally observed with greater light exposure. This environmental adaptation was confirmed by the less marked decrease in S. nigrum harvest index. Agroecological involvements are discussed.

  11. Identifying genes involved in the interaction of Aggregatibacter actinomycetemcomitans with Maillard reaction products (MRP)

    Science.gov (United States)

    Jaha, Raniah Abdulmohsen

    Aggregatibacter (Actinobacillus) actinomycelemcomitcrns is a gram-negative bacterium that is a facultative anaerobe which can grow in either aerobic or anaerobic conditions. The bacteria cause localized aggressive periodontitis that can result in the loss of teeth and endocarditis, which is an infection of the heart valves. A rich medium is an essential requirement for its growth. There arc some difficulties associated with growing the bacteria as they easily switch from the rough to smooth phenotype under no specific conditions. The bacteria start to lose viability after about 19 hours of growth in broth or about three days on plates. Colonies in the dense part of the streak on plates die earlier. It was shown that acid secreted by the colonies is responsible for the loss of viability as the bacteria are extremely sensitive to low pH. Autoclaving the growth medium for A. actinomycetemcomitans causes the bacteria to grow slowly because of the formation of Maillard reaction products (MRPs). A method has been developed to make the A. actinomycetemcomitans growth medium using the microwave instead of the autoclave. This method produces much less of the inhibitory product since the heating time is only six minutes, compared to more than an hour when using the autoclave. Two approaches were sought in this research. The first approach was the identification of genes responsible for the interaction between the MRP and A. actinomycetemcomitans. The gene responsible for this interaction was found to be a Lys M protein which is found in many genes responsible for the cell wall integrity. The second approach was to develop a new drug made of glucose and lysine with a minimum inhibitory concentration as 75mM.

  12. Time-explicit methods for joint economical and geological risk mitigation in production optimization

    DEFF Research Database (Denmark)

    Christiansen, Lasse Hjuler; Capolei, Andrea; Jørgensen, John Bagterp

    2016-01-01

    Real-life applications of production optimization face challenges of risks related to unpredictable fluctuations in oil prices and sparse geological data. Consequently, operating companies are reluctant to adopt model-based production optimization into their operations. Conventional production...... of mitigating economical and geological risks. As opposed to conventional strategies that focus on a single long-term objective, TE methods seek to reduce risks and promote returns over the entire reservoir life by optimization of a given ensemble-based geological risk measure over time. By explicit involvement...... of time, economical risks are implicitly addressed by balancing short-term and long-term objectives throughout the reservoir life. Open-loop simulations of a two-phase synthetic reservoir demonstrate that TE methods may significantly improve short-term risk measures such as expected return, standard...

  13. Method for Hot Real-Time Sampling of Gasification Products

    Energy Technology Data Exchange (ETDEWEB)

    Pomeroy, Marc D [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-09-29

    The Thermochemical Process Development Unit (TCPDU) at the National Renewable Energy Laboratory (NREL) is a highly instrumented half-ton/day pilot scale plant capable of demonstrating industrially relevant thermochemical technologies from lignocellulosic biomass conversion, including gasification. Gasification creates primarily Syngas (a mixture of Hydrogen and Carbon Monoxide) that can be utilized with synthesis catalysts to form transportation fuels and other valuable chemicals. Biomass derived gasification products are a very complex mixture of chemical components that typically contain Sulfur and Nitrogen species that can act as catalysis poisons for tar reforming and synthesis catalysts. Real-time hot online sampling techniques, such as Molecular Beam Mass Spectrometry (MBMS), and Gas Chromatographs with Sulfur and Nitrogen specific detectors can provide real-time analysis providing operational indicators for performance. Sampling typically requires coated sampling lines to minimize trace sulfur interactions with steel surfaces. Other materials used inline have also shown conversion of sulfur species into new components and must be minimized. Sample line Residence time within the sampling lines must also be kept to a minimum to reduce further reaction chemistries. Solids from ash and char contribute to plugging and must be filtered at temperature. Experience at NREL has shown several key factors to consider when designing and installing an analytical sampling system for biomass gasification products. They include minimizing sampling distance, effective filtering as close to source as possible, proper line sizing, proper line materials or coatings, even heating of all components, minimizing pressure drops, and additional filtering or traps after pressure drops.

  14. Family involvement in timely detection of changes in health of nursing homes residents: A qualitative exploratory study.

    Science.gov (United States)

    Powell, Catherine; Blighe, Alan; Froggatt, Katherine; McCormack, Brendan; Woodward-Carlton, Barbara; Young, John; Robinson, Louise; Downs, Murna

    2018-01-01

    To explore family perspectives on their involvement in the timely detection of changes in their relatives' health in UK nursing homes. Increasingly, policy attention is being paid to the need to reduce hospitalisations for conditions that, if detected and treated in time, could be managed in the community. We know that family continue to be involved in the care of their family members once they have moved into a nursing home. Little is known, however, about family involvement in the timely detection of changes in health in nursing home residents. Qualitative exploratory study with thematic analysis. A purposive sampling strategy was applied. Fourteen semi-structured one-to-one interviews with family members of people living in 13 different UK nursing homes. Data were collected from November 2015-March 2016. Families were involved in the timely detection of changes in health in three key ways: noticing signs of changes in health, informing care staff about what they noticed and educating care staff about their family members' changes in health. Families suggested they could be supported to detect timely changes in health by developing effective working practices with care staff. Families can provide a special contribution to the process of timely detection in nursing homes. Their involvement needs to be negotiated, better supported, as well as given more legitimacy and structure within the nursing home. Families could provide much needed support to nursing home nurses, care assistants and managers in timely detection of changes in health. This may be achieved through communication about their preferred involvement on a case-by-case basis as well as providing appropriate support or services. © 2017 The Authors. Journal of Clinical Nursing Published by John Wiley & Sons Ltd.

  15. Consumer perception of food products involving genetic modification: Results from a qualitative study in four Nordic countries

    DEFF Research Database (Denmark)

    Grunert, Klaus G.; Lähteenmäki, Liisa; Nielsen, Niels Asger

    2000-01-01

    1. The present study addresses consumer acceptance of food products involving the use of different applications of genetic modification in four Nordic countries. Three food products were used as examples: hard cheese, hard candy, and salmon. Three types of applications of genetic modification were...... in the final product has a clear impact on consumer acceptance. When the GM material is present and viable/able to function, acceptance is lowest. 5. The type of application of genetic modification has an impact on consumer acceptance as well, but it differs across products. Still, there is a clear tendency...

  16. Closed-form expressions for time-frequency operations involving Hermite functions

    NARCIS (Netherlands)

    Korevaar, C.W.; Oude Alink, M.S.; de Boer, Pieter-Tjerk; Kokkeler, Andre B.J.; Smit, Gerardus Johannes Maria

    2016-01-01

    The product, convolution, correlation, Wigner distribution function (WDF) and ambiguity function (AF) of two Hermite functions of arbitrary order n and m are derived and expressed as a bounded, weighted sum of n+m Hermite functions. It was already known that these mathematical operations performed

  17. Analytical model for advective-dispersive transport involving flexible boundary inputs, initial distributions and zero-order productions

    Science.gov (United States)

    Chen, Jui-Sheng; Li, Loretta Y.; Lai, Keng-Hsin; Liang, Ching-Ping

    2017-11-01

    A novel solution method is presented which leads to an analytical model for the advective-dispersive transport in a semi-infinite domain involving a wide spectrum of boundary inputs, initial distributions, and zero-order productions. The novel solution method applies the Laplace transform in combination with the generalized integral transform technique (GITT) to obtain the generalized analytical solution. Based on this generalized analytical expression, we derive a comprehensive set of special-case solutions for some time-dependent boundary distributions and zero-order productions, described by the Dirac delta, constant, Heaviside, exponentially-decaying, or periodically sinusoidal functions as well as some position-dependent initial conditions and zero-order productions specified by the Dirac delta, constant, Heaviside, or exponentially-decaying functions. The developed solutions are tested against an analytical solution from the literature. The excellent agreement between the analytical solutions confirms that the new model can serve as an effective tool for investigating transport behaviors under different scenarios. Several examples of applications, are given to explore transport behaviors which are rarely noted in the literature. The results show that the concentration waves resulting from the periodically sinusoidal input are sensitive to dispersion coefficient. The implication of this new finding is that a tracer test with a periodic input may provide additional information when for identifying the dispersion coefficients. Moreover, the solution strategy presented in this study can be extended to derive analytical models for handling more complicated problems of solute transport in multi-dimensional media subjected to sequential decay chain reactions, for which analytical solutions are not currently available.

  18. Employee Involvement and Organizational Citizenship: Implications for Labor Law Reform and "Lean Production."

    Science.gov (United States)

    Cappelli, Peter; Rogovsky, Nikolai

    1998-01-01

    Organizational citizenship--behavior that promotes organizations without explicit reward--was measured in a survey of 512 employees and 91 supervisors. Involvement in work organization increased citizenship behavior indirectly by changing job characteristics. Involvement in decisions about employment practices had little or no effect. (SK)

  19. Means-End Chains for low involvement food products: A study of Danish consumers' cognitions regarding different applications of vegetable oil

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Nielsen, Niels Asger; Grunert, Klaus G.

    to the use of laddering with low involvement products (Durgee, 1986), the neglecting of the situational factor when doing laddering interviews (eg, Pieters, Steenkamp, & Wedel, 1992), and the lack of a from means-ends chains to constructs which ar e closer to the actual behaviour of consumers (Grunert......In recent years, means-end chains and the laddering technique as a way to measure them have become popular in consumer reserach. At the same time, however, a substantial amount of critique regarding the validity of the theory as well as the method been publsihed. Some of this critique relates...... & Gruenert, 1995). This paper reports on a study in which laddering was used to measure means-end chains for a low involvement product, explicitly controlling for situational factors. Also, a possible way of linking means-ends data to overall product percpetions is presented. The study is part of the Danish...

  20. Production of pizza dough with reduced fermentation time

    Directory of Open Access Journals (Sweden)

    Simone Limongi

    2012-12-01

    Full Text Available The aim of this study was to reduce the fermentation time of pizza dough by evaluating the development of the dough during fermentation using a Chopin® rheofermentometer and verifying the influence of time and temperature using a 2² factorial design. The focus was to produce characteristic soft pizza dough with bubbles and crispy edges and soft in the center. These attributes were verified by the Quantitative Descriptive Analysis (QDA. The dough was prepared with the usual ingredients, fermented at a temperature range from 27 to 33 ºC for 30 to 42 minutes, enlarged, added with tomato sauce, baked, and frozen. The influence of the variables time and temperature on the release of carbon dioxide (H'm was confirmed with positive and significant effect, using a rheofermentometer, which was not observed for the development or maximum height of the dough (Hm. The same fermentation conditions of the experimental design were used for the production of the pizza dough in the industrial process; it was submitted to Quantitative Descriptive Analysis (QDA, in which the samples were described by nine attributes. The results showed that some samples had the desired characteristics of pizza dough, demonstrated by the principal component analysis (PCA, indicating a 30 % fermentation time reduction when compared to the conventional process.

  1. New Product Development in an Emerging Economy: Analysing the Role of Supplier Involvement Practices by Using Bayesian Markov Chain Monte Carlo Technique

    Directory of Open Access Journals (Sweden)

    Kanagi Kanapathy

    2014-01-01

    Full Text Available The research question is whether the positive relationship found between supplier involvement practices and new product development performances in developed economies also holds in emerging economies. The role of supplier involvement practices in new product development performance is yet to be substantially investigated in the emerging economies (other than China. This premise was examined by distributing a survey instrument (Jayaram’s (2008 published survey instrument that has been utilised in developed economies to Malaysian manufacturing companies. To gauge the relationship between the supplier involvement practices and new product development (NPD project performance of 146 companies, structural equation modelling was adopted. Our findings prove that supplier involvement practices have a significant positive impact on NPD project performance in an emerging economy with respect to quality objectives, design objectives, cost objectives, and “time-to-market” objectives. Further analysis using the Bayesian Markov Chain Monte Carlo algorithm, yielding a more credible and feasible differentiation, confirmed these results (even in the case of an emerging economy and indicated that these practices have a 28% impact on variance of NPD project performance. This considerable effect implies that supplier involvement is a must have, although further research is needed to identify the contingencies for its practices.

  2. Employee self-rated productivity and objective organizational production levels: effects of worksite health interventions involving reduced work hours and physical exercise.

    Science.gov (United States)

    von Thiele Schwarz, Ulrica; Hasson, Henna

    2011-08-01

    To investigate how worksite health interventions involving a 2.5-hour reduction of weekly working hours with (PE) or without (RWH) mandatory physical exercise affects productivity. Six workplaces in dental health care were matched and randomized to three conditions (PE, RWH and referents). Employees' (N = 177) self-rated productivity and the workplaces' production levels (number of patients) were examined longitudinally. Number of treated patients increased in all conditions during the intervention year. While RWH showed the largest increase in this measure, PE showed significant increases in self-rated productivity, that is, increased quantity of work and work-ability and decreased sickness absence. A reduction in work hours may be used for health promotion activities with sustained or improved production levels, suggesting an increased productivity since the same, or higher, production level can be achieved with lesser resources.

  3. Deformation analysis of polymers composites: rheological model involving time-based fractional derivative

    DEFF Research Database (Denmark)

    Zhou, H. W.; Yi, H. Y.; Mishnaevsky, Leon

    2017-01-01

    A modeling approach to time-dependent property of Glass Fiber Reinforced Polymers (GFRP) composites is of special interest for quantitative description of long-term behavior. An electronic creep machine is employed to investigate the time-dependent deformation of four specimens of dog-bond-shaped......A modeling approach to time-dependent property of Glass Fiber Reinforced Polymers (GFRP) composites is of special interest for quantitative description of long-term behavior. An electronic creep machine is employed to investigate the time-dependent deformation of four specimens of dog......-bond-shaped GFRP composites at various stress level. A negative exponent function based on structural changes is introduced to describe the damage evolution of material properties in the process of creep test. Accordingly, a new creep constitutive equation, referred to fractional derivative Maxwell model...... by the fractional derivative Maxwell model proposed in the paper are in a good agreement with the experimental data. It is shown that the new creep constitutive model proposed in the paper needs few parameters to represent various time-dependent behaviors....

  4. Extension of the time-average model to Candu refueling schemes involving reshuffling

    International Nuclear Information System (INIS)

    Rouben, Benjamin; Nichita, Eleodor

    2008-01-01

    Candu reactors consist of a horizontal non-pressurized heavy-water-filled vessel penetrated axially by fuel channels, each containing twelve 50-cm-long fuel bundles cooled by pressurized heavy water. Candu reactors are refueled on-line and, as a consequence, the core flux and power distributions change continuously. For design purposes, a 'time-average' model was developed in the 1970's to calculate the average over time of the flux and power distribution and to study the effects of different refueling schemes. The original time-average model only allows treatment of simple push-through refueling schemes whereby fresh fuel is inserted at one end of the channel and irradiated fuel is removed from the other end. With the advent of advanced fuel cycles and new Candu designs, novel refueling schemes may be considered, such as reshuffling discharged fuel from some channels into other channels, to achieve better overall discharge burnup. Such reshuffling schemes cannot be handled by the original time-average model. This paper presents an extension of the time-average model to allow for the treatment of refueling schemes with reshuffling. Equations for the extended model are presented, together with sample results for a simple demonstration case. (authors)

  5. SACE_5599, a putative regulatory protein, is involved in morphological differentiation and erythromycin production in Saccharopolyspora erythraea.

    Science.gov (United States)

    Kirm, Benjamin; Magdevska, Vasilka; Tome, Miha; Horvat, Marinka; Karničar, Katarina; Petek, Marko; Vidmar, Robert; Baebler, Spela; Jamnik, Polona; Fujs, Štefan; Horvat, Jaka; Fonovič, Marko; Turk, Boris; Gruden, Kristina; Petković, Hrvoje; Kosec, Gregor

    2013-12-17

    Erythromycin is a medically important antibiotic, biosynthesized by the actinomycete Saccharopolyspora erythraea. Genes encoding erythromycin biosynthesis are organized in a gene cluster, spanning over 60 kbp of DNA. Most often, gene clusters encoding biosynthesis of secondary metabolites contain regulatory genes. In contrast, the erythromycin gene cluster does not contain regulatory genes and regulation of its biosynthesis has therefore remained poorly understood, which has for a long time limited genetic engineering approaches for erythromycin yield improvement. We used a comparative proteomic approach to screen for potential regulatory proteins involved in erythromycin biosynthesis. We have identified a putative regulatory protein SACE_5599 which shows significantly higher levels of expression in an erythromycin high-producing strain, compared to the wild type S. erythraea strain. SACE_5599 is a member of an uncharacterized family of putative regulatory genes, located in several actinomycete biosynthetic gene clusters. Importantly, increased expression of SACE_5599 was observed in the complex fermentation medium and at controlled bioprocess conditions, simulating a high-yield industrial fermentation process in the bioreactor. Inactivation of SACE_5599 in the high-producing strain significantly reduced erythromycin yield, in addition to drastically decreasing sporulation intensity of the SACE_5599-inactivated strains when cultivated on ABSM4 agar medium. In contrast, constitutive overexpression of SACE_5599 in the wild type NRRL23338 strain resulted in an increase of erythromycin yield by 32%. Similar yield increase was also observed when we overexpressed the bldD gene, a previously identified regulator of erythromycin biosynthesis, thereby for the first time revealing its potential for improving erythromycin biosynthesis. SACE_5599 is the second putative regulatory gene to be identified in S. erythraea which has positive influence on erythromycin yield. Like bld

  6. TAEKWONDO TECHNIQUES AND COMPETITION CHARACTERISTICS INVOLVED IN TIME-LOSS INJURIES

    Directory of Open Access Journals (Sweden)

    Konstantinos Beis

    2007-10-01

    Full Text Available The purpose of this study was to assess time-loss injuries in young and adult taekwondo athletes. Participants were 2739 children (11-13 years, Junior (14-17 years and adult males and females (18 years and older competing in the national Greek championships. Injury data were collected by project staff with all diagnoses made by the tournament physician. Odds ratios were computed as well as 95% confidence intervals around the injury rates. The female Juniors had a higher time-loss injury rate (Fisher's Exact Test p = 0.033 than their adult counterparts. However, they were not at a higher risk of incurring a time-loss injury: OR = 0.143, 95% CI: 0.018-1.124. Collapsed over age, the females as a group recorded more time-loss injuries [11.36/1,000 A-E (95% CI: 6.25-16.47 versus 7.40/1,000 A-E (95% CI: 4.44-10.36], but this was not significant (OR = 0.703, 95% CI: 0.383-1.293. In the Juniors, the boys only incurred time-loss injuries to the head and neck. There was no difference in the Junior girls in the distribution of time-loss injuries across body region, although they were at higher risk of sustaining an injury to the head and neck (OR = 1.510, 95% CI: 0.422-5.402 but this was not statistically significant. Although there were no statistical differences among age groups within gender, the Junior boys and girls (11-13 years sustained more cerebral concussions. The Junior boys were at a higher risk of incurring a cerebral concussion than the boys (OR = 7.871, 95% CI: 0.917-67.583, Fisher's Exact Test p = 0.036. In the males, there was no difference between the men and Junior boys in injury rate for swing kicks compared to other techniques (OR = 2.000, 95% CI = 0.397-28.416. There also was no difference between the men and boys (OR = 4.800, 95% CI: 0.141-58.013. To help reduce the incidence of time-loss injuries in taekwondo, especially cerebral concussions, it is suggested for coaches to emphasize blocking skills. Educating referees, coaches and

  7. Productivity analysis to overcome the limited availability of production time in SME FBS

    Science.gov (United States)

    Nurhasanah, N.; Jingga; Aribowo, B.; Gayatri, AM; Mardhika, DA; Tanjung, WN; Suri, QA; Safitri, R.; Supriyanto, A.

    2017-12-01

    Good industrial development should pay attention to the human factor as the main driver. Condition of work procedures, work area, and environment can affect the production result because if not optimal, the production will run slowly. If the work system is less than optimal, the productivity will do so, the operator will work uncomfortably and be easy to undergo work fatigue, even it can cause work accidents. Thus, the optimal and ergonomic arrangement of the the overall work system mechanism and work environment design is required for workers to work well, regularly, safely and comfortably with the aim of improving work productivity. This research measures the performance in textile SME (Small and Medium Enterprise) located in Sukabumi which is SME FBS which produces children’s clothing. This performance measurement is aimed at improving the competitiveness of the textile IKM so that it has the equal competitiveness with other SMEs or with textile industries that already have their name in market. Based on the method of hour standard time and TOC calculation at 2 FBS CMT (Cut-Make-Trim) in Sukabumi, which are the CMT Margaluyu Village and CMT Purabaya Village, the result is that the standard time of shirt work on CMT Margaluyu Village is less than that of CMT Desa Purabaya. It can be seen that more effective in SME FBS production is by process method.

  8. Productivity improvement: Implementation and analysis of clustering technique in manufacturing of timing gearbox cover

    Directory of Open Access Journals (Sweden)

    Satbir Singh

    2016-04-01

    Full Text Available Productivity is an indicator of efficiency with which resources, both human and material, are transformed into useful services and goods. The vital purpose of the prevailing work was to analyze the factors involved in the improvement of productivity in all its types such as material, capital, labor, machine and total productivity at the plant. This was obtained by decreasing the manufacturing cost per component by reducing its cycle time and increasing the monthly production rate. The experimentation revealed that using proposed processes and improved tooling, monthly production rate has increased by 16.2% due to reduced cycle time, the number of defected components i.e. rejection rate has reduced up to 2%. A reduction of 6.78% in manufacturing cost per component was recorded. Tooling cost has reduced by more than 12%. Saving up to 50% in inspection cost has been recorded due to close dimensional tolerances and high surface finish achieved on components. An increase of 4.84% was recorded in total productivity.

  9. Parent-adolescent joint projects involving leisure time and activities during the transition to high school.

    Science.gov (United States)

    Marshall, Sheila K; Young, Richard A; Wozniak, Agnieszka; Lollis, Susan; Tilton-Weaver, Lauree; Nelson, Margo; Goessling, Kristen

    2014-10-01

    Leisure research to date has generally overlooked planning and organizing of leisure time and activities between parents and adolescents. This investigation examined how a sample of Canadian adolescents and their parents jointly constructed and acted on goals related to adolescents' leisure time during the move from elementary to high school. Using the Qualitative Action-Project Method, data were collected over an 8-10 month period from 26 parent-adolescent dyads located in two urban sites, through video-taped conversations about leisure time, video recall interviews, and telephone monitoring interviews. Analysis of the data revealed that the joint projects of the 26 dyads could be grouped into three clusters: a) governance transfer or attempts to shift, from parent to adolescent, responsibility over academic demands, organizing leisure time, and safety with peers, b) balancing extra-curricular activities with family life, academics, and social activities, and c) relationship adjustment or maintenance. Crown Copyright © 2014. Published by Elsevier Ltd. All rights reserved.

  10. Higher order multi-term time-fractional partial differential equations involving Caputo-Fabrizio derivative

    Directory of Open Access Journals (Sweden)

    Erkinjon Karimov

    2017-10-01

    Full Text Available In this work we discuss higher order multi-term partial differential equation (PDE with the Caputo-Fabrizio fractional derivative in time. Using method of separation of variables, we reduce fractional order partial differential equation to the integer order. We represent explicit solution of formulated problem in particular case by Fourier series.

  11. Higher order multi-term time-fractional partial differential equations involving Caputo-Fabrizio derivative

    OpenAIRE

    Erkinjon Karimov; Sardor Pirnafasov

    2017-01-01

    In this work we discuss higher order multi-term partial differential equation (PDE) with the Caputo-Fabrizio fractional derivative in time. Using method of separation of variables, we reduce fractional order partial differential equation to the integer order. We represent explicit solution of formulated problem in particular case by Fourier series.

  12. Intramuscular tendon involvement on MRI has limited value for predicting time to return to play following acute hamstring injury.

    Science.gov (United States)

    van der Made, Anne D; Almusa, Emad; Whiteley, Rod; Hamilton, Bruce; Eirale, Cristiano; van Hellemondt, Frank; Tol, Johannes L

    2018-01-01

    Hamstring injury with intramuscular tendon involvement is regarded as a serious injury with a delay in return to play (RTP) of more than 50 days and reinjury rates up to 63%. However, this reputation is based on retrospective case series with high risk of bias. Determine whether intramuscular tendon involvement is associated with delayed RTP and elevated rates of reinjury. MRI of male athletes with an acute hamstring injury was obtained within 5 days of injury. Evaluation included standardised MRI scoring and scoring of intramuscular tendon involvement. Time to RTP and reinjury rate were prospectively recorded. Out of 70 included participants, intramuscular tendon disruption was present in 29 (41.4%) injuries. Injuries without intramuscular tendon disruption had a mean time to RTP of 22.2±7.4 days. Injuries with Injuries with full-thickness disruption took longer to RTP compared with injuries without disruption (p=0.025). Longitudinal intramuscular tendon disruption was not significantly associated with time to RTP. Waviness was present in 17 (24.3%) injuries. Mean time to RTP for injuries without and with waviness was 22.6±7.5 and 30.2±10.8 days (p=0.014). There were 11 (15.7%) reinjuries within 12 months, five (17.2%) in the group with intramuscular tendon disruption and six (14.6%) in the group without intramuscular tendon disruption. Time to RTP for injuries with full-thickness disruption of the intramuscular tendon and waviness is significantly longer (by slightly more than 1 week) compared with injuries without intramuscular tendon involvement. However, due to the considerable overlap in time to RTP between groups with and without intramuscular tendon involvement, its clinical significance for the individual athlete is limited. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  13. Assimilation of LAI time-series in crop production models

    Science.gov (United States)

    Kooistra, Lammert; Rijk, Bert; Nannes, Louis

    2014-05-01

    Agriculture is worldwide a large consumer of freshwater, nutrients and land. Spatial explicit agricultural management activities (e.g., fertilization, irrigation) could significantly improve efficiency in resource use. In previous studies and operational applications, remote sensing has shown to be a powerful method for spatio-temporal monitoring of actual crop status. As a next step, yield forecasting by assimilating remote sensing based plant variables in crop production models would improve agricultural decision support both at the farm and field level. In this study we investigated the potential of remote sensing based Leaf Area Index (LAI) time-series assimilated in the crop production model LINTUL to improve yield forecasting at field level. The effect of assimilation method and amount of assimilated observations was evaluated. The LINTUL-3 crop production model was calibrated and validated for a potato crop on two experimental fields in the south of the Netherlands. A range of data sources (e.g., in-situ soil moisture and weather sensors, destructive crop measurements) was used for calibration of the model for the experimental field in 2010. LAI from cropscan field radiometer measurements and actual LAI measured with the LAI-2000 instrument were used as input for the LAI time-series. The LAI time-series were assimilated in the LINTUL model and validated for a second experimental field on which potatoes were grown in 2011. Yield in 2011 was simulated with an R2 of 0.82 when compared with field measured yield. Furthermore, we analysed the potential of assimilation of LAI into the LINTUL-3 model through the 'updating' assimilation technique. The deviation between measured and simulated yield decreased from 9371 kg/ha to 8729 kg/ha when assimilating weekly LAI measurements in the LINTUL model over the season of 2011. LINTUL-3 furthermore shows the main growth reducing factors, which are useful for farm decision support. The combination of crop models and sensor

  14. Crowdsourcing ideas : Involving ordinary users in the ideation phase of new product development

    NARCIS (Netherlands)

    Schemmann, Brita; Herrmann, Andrea M.; Chappin, Maryse M H; Heimeriks, Gaston J.

    2016-01-01

    The different roles of users in new product development (NPD) have been extensively described. Currently online idea crowdsourcing, via long-term open idea calls, is increasingly being used by companies to collect new product ideas from ordinary users. Such open idea calls can result in thousands of

  15. On a higher order multi-term time-fractional partial differential equation involving Caputo-Fabrizio derivative

    OpenAIRE

    Pirnapasov, Sardor; Karimov, Erkinjon

    2017-01-01

    In the present work we discuss higher order multi-term partial differential equation (PDE) with the Caputo-Fabrizio fractional derivative in time. We investigate a boundary value problem for fractional heat equation involving higher order Caputo-Fabrizio derivatives in time-variable. Using method of separation of variables and integration by parts, we reduce fractional order PDE to the integer order. We represent explicit solution of formulated problem in particular case by Fourier series.

  16. On the stability analysis of a general discrete-time population model involving predation and Allee effects

    International Nuclear Information System (INIS)

    Merdan, H.; Duman, O.

    2009-01-01

    This paper presents the stability analysis of equilibrium points of a general discrete-time population dynamics involving predation with and without Allee effects which occur at low population density. The mathematical analysis and numerical simulations show that the Allee effect has a stabilizing role on the local stability of the positive equilibrium points of this model.

  17. Implementation of Releasing Time to Care - the productive ward.

    Science.gov (United States)

    Wilson, Gwyneth

    2009-07-01

    This paper describes the implementation of the NHS Institute for Innovation and Improvement Productive Ward - releasing time to care programme. It will discuss the benefits and key successes and provides advice for those wishing to implement the programme. In Lord Darzi's Next Stage Review, he advocates an ambitious vision of patient centred - clinician led, locally driven NHS. The Releasing Time to Care programme is a unique opportunity for everyone working within the NHS to improve effectiveness, safety and reliability of the services we provide. Whilst being situated within a National Health Service policy environment learning from this work can be translated nationally and internationally, as the principles underpin the provision of high quality care. Evaluation is currently in relation to each of the 15 modules rather than as the programme as a whole. It uses various methods including audit, observation, activity follow through, satisfaction surveys and process mapping. Each month data is colated for each of the 11 metrics which has shown a reduction in falls, drug administration errors and improvement in the recording of patient observations. One of the key issues is that an essential component for the success of the programme lies in the tangible support of the Trust Board/Board of Directors. Evidence shows that this programme improves patient satisfaction as it enables the provision of an increase in direct patient care by staff and subsequently improved clinical and safety outcomes. Ward Sister/Charge Nurse development includes Leadership, Project management and Lean Methodology techniques. The Releasing Time to Care programme is a key component of the Next Stage Review. It will create productive organisations by being a catalyst for the transformation of Trust services, enabling staff to spend more time caring for patients and users. This release in time will result in better outcomes and subsequent improvement with patient and staff satisfaction and

  18. Gauge fields in nonlinear group realizations involving two-dimensional space-time symmetry

    International Nuclear Information System (INIS)

    Machacek, M.E.; McCliment, E.R.

    1975-01-01

    It is shown that gauge fields may be consistently introduced into a model Lagrangian previously considered by the authors. The model is suggested by the spontaneous breaking of a Lorentz-type group into a quasiphysical two-dimensional space-time and one internal degree of freedom, loosely associated with charge. The introduction of zero-mass gauge fields makes possible the absorption via the Higgs mechanism of the Goldstone fields that appear in the model despite the fact that the Goldstone fields do not transform as scalars. Specifically, gauge invariance of the Yang-Mills type requires the introduction of two sets of massless gauge fields. The transformation properties in two-dimensional space-time suggest that one set is analogous to a charge doublet that behaves like a second-rank tensor in real four-dimensional space time. The other set suggests a spin-one-like charge triplet. Via the Higgs mechanism, the first set absorbs the Goldstone fields and acquires mass. The second set remains massless. If massive gauge fields are introduced, the associated currents are not conserved and the Higgs mechanism is no longer fully operative. The Goldstone fields are not eliminated, but coupling between the Goldstone fields and the gauge fields does shift the mass of the antisymmetric second-rank-tensor gauge field components

  19. Exploring Mediating and Moderating Influences on the Links between Cycle Time, Proficiency in Entry Timing and New Product Profitability

    NARCIS (Netherlands)

    Langerak, F.; Hultink, E.J.; Griffin, A.

    2006-01-01

    Development cycle time is the elapsed time from the beginning of idea generation to the moment that the new product is ready for market introduction. Market entry timing is contingent upon the new product’s cycle time. Only when the product is completed can a firm decide whether and when to enter

  20. Increased Production of Hydrogen Peroxide by Lactobacillus delbrueckii subsp. bulgaricus upon Aeration: Involvement of an NADH Oxidase in Oxidative Stress

    Science.gov (United States)

    Marty-Teysset, C.; de la Torre, F.; Garel, J.-R.

    2000-01-01

    The growth of Lactobacillus delbrueckii subsp. bulgaricus (L. delbrueckii subsp. bulgaricus) on lactose was altered upon aerating the cultures by agitation. Aeration caused the bacteria to enter early into stationary phase, thus reducing markedly the biomass production but without modifying the maximum growth rate. The early entry into stationary phase of aerated cultures was probably related to the accumulation of hydrogen peroxide in the medium. Indeed, the concentration of hydrogen peroxide in aerated cultures was two to three times higher than in unaerated ones. Also, a similar shift from exponential to stationary phase could be induced in unaerated cultures by adding increasing concentrations of hydrogen peroxide. A significant fraction of the hydrogen peroxide produced by L. delbrueckii subsp. bulgaricus originated from the reduction of molecular oxygen by NADH catalyzed by an NADH:H2O2 oxidase. The specific activity of this NADH oxidase was the same in aerated and unaerated cultures, suggesting that the amount of this enzyme was not directly regulated by oxygen. Aeration did not change the homolactic character of lactose fermentation by L. delbrueckii subsp. bulgaricus and most of the NADH was reoxidized by lactate dehydrogenase with pyruvate. This indicated that NADH oxidase had no (or a very small) energetic role and could be involved in eliminating oxygen. PMID:10618234

  1. Methods and Techniques. Student Involvement in the Production of Teaching Aids.

    Science.gov (United States)

    Fernau, C.

    1984-01-01

    Indicates that teaching materials used in industrialized countries are not appropriate and often cannot be adapted for the use in developing countries. Having students help with production of teaching aids increases their motivation for using them. (JOW)

  2. Health and productivity of commuter railroad employees involved in critical incidents.

    Science.gov (United States)

    2011-02-15

    ABSTRACTThe effects of accidentstermed Critical Incidentson the health and productivity of rail transit workers have not been fully investigated. Anecdotal evidence suggests lasting effects of these incidents. Surveys were obtained from 363 com...

  3. Means-end chains for low involvement products: A study of Danish consumers' cognitions regarding different applications of vegetable oil

    DEFF Research Database (Denmark)

    Bech-Larsen, Tino; Nielsen, Niels Asger; Grunert, Klaus G.

    value maps', which are normally used for analysing laddering data, have been criticised for being questionable representations of raw data. 3. This paper reports on a study in which laddering was used to measure means-end chains for a low involvement product (vegetable oil), explicitly controlling....... 2. Some of the critique relates to the use of laddering with low involvement products, neglect of the situational factor when making laddering interviews, and the lack of a link from means-ends chains to constructs which are closer to the actual behaviour of consumers. Furthermore 'hierarchical...... for the situation. Also, a possible way of linking means-ends data to overall product perceptions and alternat the 'hierarchical value map' analysis are presented. 4. The study presented is part of the Danish research project Rape seed oil for human consumption. Although modern Danish rape seed oil has nutritional...

  4. Customer Involvement in the Development of New Sustainable Products: A Review of the Literature

    OpenAIRE

    Natalia Moreira; Trevor Wood-Harper

    2015-01-01

    The acceptance of sustainable products by the final consumer is still one of the challenges of the industry, which constantly seeks alternative approaches to successfully be accepted in the global market. A large set of methods and approaches have been discussed and analysed throughout the literature. Considering the current need for sustainable development and the current pace of consumption, the need for a combined solution towards the development of new products became c...

  5. Development and capital investment tasks involved in the production of charge transfer equipment

    International Nuclear Information System (INIS)

    Simon, Sandor

    1983-01-01

    Stringent requirements had to be considered in the course of the production development of charge transfer equipment. The production of structures demanding extremely high endurance was based on extensive co-operation. Special alloys were needed for parts and bearings, special heat-treatment was required at certain sections for large dimensions etc. Appropriate mashine stock, assembly and test hall have been built for assembling and testing the equipment with both 440 and 100 MW.(Sz.J.)

  6. Involving consumers in product design through collaboration: the case of online role-playing games.

    Science.gov (United States)

    Yeh, Shu-Yu

    2010-12-01

    The release of software attributes to users by software designers for the creation of user-designed forms is regarded as a producer-consumer collaboration, leading consumers to expend significant effort on a specific product. This article identifies such software/product attributes within online role-playing games and then explores how consumers' prior experience affects the evaluation of such attributes. In this article, product attributes comprise customized, content, and interactive externality-sensitive and complementary externality-sensitive attributes, with the value of each attribute being greater for experts than for novices. In Study 1, data were collected and analyzed for the purpose of identifying such features in online role-playing games. The results can also be generalized to convergent products, such as TV games that have been redesigned as online games or mobile games found in Study 2. For the introduction of a convergent product to be successful, our research suggests that the potential market-segment focus should be on knowledgeable consumers who accept such products more readily.

  7. Involvement of DNA polymerase δ in DNA repair synthesis in human fibroblasts at late times after ultraviolet irradiation

    International Nuclear Information System (INIS)

    Dresler, S.L.; Gowans, B.J.; Robinson-Hill, R.M.; Hunting, D.J.

    1988-01-01

    DNA repair synthesis following UV irradiation of confluent human fibroblasts has a biphasic time course with an early phase of rapid nucleotide incorporation and a late phase of much slower nucleotide incorporation. The biphasic nature of this curve suggests that two distinct DNA repair systems may be operative. Previous studies have specifically implicated DNA polymerase δ as the enzyme involved in DNA repair synthesis occurring immediately after UV damage. In this paper, the authors describe studies of DNA polymerase involvement in DNA repair synthesis in confluent human fibroblasts at late times after UV irradiation. Late UV-induced DNA repair synthesis in both intact and permeable cells was found to be inhibited by aphidicolin, indicating the involvement of one of the aphidicolin-sensitive DNA polymerases, α or δ. In permeable cells, the process was further analyzed by using the nucleotide analogue (butylphenyl)-2'-deoxyguanosine 5'-triphosphate, which inhibits DNA polymerase α several hundred times more strongly than it inhibits DNA polymerase δ. The (butylphenyl)-2'-deoxyguanosine 5'-triphosphate inhibition curve for late UV-induced repair synthesis was very similar to that for polymerase δ. It appears that repair synthesis at late time after UV irradiation, like repair synthesis at early times, is mediated by DNA polymerase δ

  8. Room for manoeuvre in time of the workforce in dairy production systems

    Directory of Open Access Journals (Sweden)

    Joel Carneiro dos Santos Filho

    2012-12-01

    Full Text Available The objective of this study was to characterize and to analyze the room for manoeuvre in time in dairy production systems (DPS. Two interviews were conducted in twenty DPS in the Northern region of Paraná, Brazil, with the following objectives: to know the management and practices involving the herd, the land area and the commercialization; and to qualify and evaluate the work organization. In order to build the variables, the repertory grid method was used, and for the typology, the graphic methodology of Bertin adapted to small samples was used. The results showed that the room for manoeuvre in time of the DPS, quantified in hours available per year, varied between the farmers and was related to routine work and seasonal work durations, as well as the autonomy of farmers to perform both works. The routine work was related to the number of cows, but was also explained by the herd management, by the transport equipment for the feed and by the workforce composition. Four types of work organization were identified between sampled DPS, based on room for manoeuvre in time and how they were built. Knowing the room for manoeuvre time and its variables, it is possible to guide the farmers to adjust their dairy production system in order to have more time available for other activities or to develop the dairy production system.

  9. Time-dependent histamine release from stored human blood products

    DEFF Research Database (Denmark)

    Nielsen, Hans Jørgen; Edvardsen, L; Vangsgaard, K

    1996-01-01

    storage. Whole blood (six units), plasma-reduced whole blood (six units), and plasma- and buffy coat-reduced (saline-adenine-glucose-mannitol) (SAGM) blood (six units) from unpaid healthy donors were stored in the blood bank for 35 days at 4 degrees C. Plasma histamine and total cell-bound histamine......Perioperative transfusion of whole blood has been shown to amplify trauma-induced immunosuppression, which could be attenuated by perioperative administration of histamine2 receptor antagonists. Supernatants from different blood products were, therefore, analysed for histamine content during.......0 (range 176.0-910.0) nmol/l in whole blood and 475.0 (range 360.0-1560.0) nmol/l in plasma-reduced whole blood, while it was undetectable in SAGM blood. Spontaneous histamine release increased in a time-dependent manner from a median of 6.7 (range 2.2-17.4) nmol/l at the time of storage to 175.0 (range 33...

  10. New developments in THz-time domain spectroscopy involving ML-VECSELs

    Science.gov (United States)

    Apostolopoulos, Vasilis; Tropper, Anne C.; Keenlyside, Benjamin; Chen-Sverre, Theo; Woods, Jonathan R. C.

    2018-02-01

    The THz time domain spectrometer (THz-TDS) has revolutionized the adoption of THz science in fields such as medicine, material characterization, pharmaceutical research and biology among others. Traditionally a THz-TDS was based on a titanium sapphire laser, while most of the commercially sold spectrometers today adopt fiber lasers. Vertical External Cavity Surface emitting lasers or VECSELs have potential to be the future laser of choice for the implementation of THz spectrometers, as they are small, low-cost, low noise and high repetition rate. Here I will outline the progress in our laboratory and the general community concerning VECSEL-THz technology and I will account the problems that have to be solved for the VECSEL-THz technology to succeed.

  11. The timing of drug funding announcements relative to elections: a case study involving dementia medications.

    Directory of Open Access Journals (Sweden)

    Sudeep S Gill

    Full Text Available Following initial regulatory approval of prescription drugs, many factors may influence insurers and health systems when they decide whether to add these drugs to their formularies. The role of political pressures on drug funding announcements has received relatively little attention, and elections represent an especially powerful form of political pressure. We examined the temporal relationship between decisions to add one class of drugs to publicly funded formularies in Canada's ten provinces and elections in these jurisdictions.Dates of provincial formulary listings for cholinesterase inhibitors, which are drugs used to treat Alzheimer's disease and related dementias, were compared to the dates of provincial elections. Medical journal articles, media reports, and proceedings from provincial legislatures were reviewed to assemble information on the chronology of events. We tested whether there was a statistically significant increase in the probability of drug funding announcements within the 60-day intervals preceding provincial elections.Decisions to fund the cholinesterase inhibitors were made over a nine-year span from 1999 to 2007 in the ten provinces. In four of ten provinces, the drugs were added to formularies in a time period closely preceding a provincial election (P = 0.032; funding announcements in these provinces were made between 2 and 47 days prior to elections. Statements made in provincial legislatures highlight the key role of political pressures in these funding announcements.Impending elections appeared to affect the timing of drug funding announcements in this case study. Despite an established structure for evidence-based decision-making, drug funding remains a complex process open to influence from many sources. Awareness of such influences is critical to maintain effective drug policy and public health decision-making.

  12. The timing of drug funding announcements relative to elections: a case study involving dementia medications.

    Science.gov (United States)

    Gill, Sudeep S; Gupta, Neeraj; Bell, Chaim M; Rochon, Paula A; Austin, Peter C; Laupacis, Andreas

    2013-01-01

    Following initial regulatory approval of prescription drugs, many factors may influence insurers and health systems when they decide whether to add these drugs to their formularies. The role of political pressures on drug funding announcements has received relatively little attention, and elections represent an especially powerful form of political pressure. We examined the temporal relationship between decisions to add one class of drugs to publicly funded formularies in Canada's ten provinces and elections in these jurisdictions. Dates of provincial formulary listings for cholinesterase inhibitors, which are drugs used to treat Alzheimer's disease and related dementias, were compared to the dates of provincial elections. Medical journal articles, media reports, and proceedings from provincial legislatures were reviewed to assemble information on the chronology of events. We tested whether there was a statistically significant increase in the probability of drug funding announcements within the 60-day intervals preceding provincial elections. Decisions to fund the cholinesterase inhibitors were made over a nine-year span from 1999 to 2007 in the ten provinces. In four of ten provinces, the drugs were added to formularies in a time period closely preceding a provincial election (P = 0.032); funding announcements in these provinces were made between 2 and 47 days prior to elections. Statements made in provincial legislatures highlight the key role of political pressures in these funding announcements. Impending elections appeared to affect the timing of drug funding announcements in this case study. Despite an established structure for evidence-based decision-making, drug funding remains a complex process open to influence from many sources. Awareness of such influences is critical to maintain effective drug policy and public health decision-making.

  13. Fatty acid biosynthesis is involved in the production of hepatitis B virus particles

    International Nuclear Information System (INIS)

    Okamura, Hitomi; Nio, Yasunori; Akahori, Yuichi; Kim, Sulyi; Watashi, Koichi; Wakita, Takaji; Hijikata, Makoto

    2016-01-01

    Hepatitis B virus (HBV) proliferates in hepatocytes after infection, but the host factors that contribute to the HBV lifecycle are poorly understood at the molecular level. We investigated whether fatty acid biosynthesis (FABS), which was recently reported to contribute to the genomic replication of hepatitis C virus, plays a role in HBV proliferation. We examined the effects of inhibitors of the enzymes in the FABS pathway on the HBV lifecycle by using recombinant HBV-producing cultured cells and found that the extracellular HBV DNA level, reflecting HBV particle production, was decreased by treatment with inhibitors suppressed the synthesis of long-chain saturated fatty acids with little cytotoxicity. The reduced HBV DNA level was reversed when palmitic acid, which is the product of fatty acid synthase (FAS) during FABS, was used simultaneously with the inhibitor. We also observed that the amount of intracellular HBV DNA in the cells was increased by FAS inhibitor treatment, suggesting that FABS is associated with HBV particle production but not its genome replication. This suggests that FABS might be a potent target for anti-HBV drug with a mode of action different from current HBV therapy. -- Highlights: •Inhibitors of ACC1 and FAS but not SCD1 decreased production of extracellular HBV DNA. •Products of FABS, long chain fatty acids, increased production of extracellular HBV DNA. •FAS inhibitor increased intracellular levels of HBV DNA and HBcAg. •FABS was suggested to contribute to HBV particle production without significant relation with secretory pathway of the cells.

  14. Fatty acid biosynthesis is involved in the production of hepatitis B virus particles

    Energy Technology Data Exchange (ETDEWEB)

    Okamura, Hitomi [Laboratory of Human Tumor Viruses, Institute for Virus Research, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507 (Japan); Graduate School of Biostudies, Kyoto University, Yoshida-Konoecho, Sakyoku, Kyoto 606-8501 (Japan); Nio, Yasunori, E-mail: yasunori.nio@takeda.com [Takeda Pharmaceutical Company Limited, Pharmaceutical Research Division, 26-1, Muraoka-Higashi 2-Chome, Fujisawa, Kanagawa 251-8555 (Japan); Akahori, Yuichi [Laboratory of Human Tumor Viruses, Institute for Virus Research, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507 (Japan); Graduate School of Biostudies, Kyoto University, Yoshida-Konoecho, Sakyoku, Kyoto 606-8501 (Japan); Kim, Sulyi [Laboratory of Human Tumor Viruses, Institute for Virus Research, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507 (Japan); Watashi, Koichi [Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640 (Japan); Department of Applied Biological Science, Tokyo University of Sciences, Noda 278-8510 (Japan); CREST, Japan Science and Technology Agency (JST), Saitama 332-0012 (Japan); Wakita, Takaji [Department of Virology II, National Institute of Infectious Diseases, Tokyo 162-8640 (Japan); Hijikata, Makoto, E-mail: mhijikat@virus.kyoto-u.ac.jp [Laboratory of Human Tumor Viruses, Institute for Virus Research, Kyoto University, 53 Kawaharacho, Shogoin, Sakyoku, Kyoto 606-8507 (Japan); Graduate School of Biostudies, Kyoto University, Yoshida-Konoecho, Sakyoku, Kyoto 606-8501 (Japan)

    2016-06-17

    Hepatitis B virus (HBV) proliferates in hepatocytes after infection, but the host factors that contribute to the HBV lifecycle are poorly understood at the molecular level. We investigated whether fatty acid biosynthesis (FABS), which was recently reported to contribute to the genomic replication of hepatitis C virus, plays a role in HBV proliferation. We examined the effects of inhibitors of the enzymes in the FABS pathway on the HBV lifecycle by using recombinant HBV-producing cultured cells and found that the extracellular HBV DNA level, reflecting HBV particle production, was decreased by treatment with inhibitors suppressed the synthesis of long-chain saturated fatty acids with little cytotoxicity. The reduced HBV DNA level was reversed when palmitic acid, which is the product of fatty acid synthase (FAS) during FABS, was used simultaneously with the inhibitor. We also observed that the amount of intracellular HBV DNA in the cells was increased by FAS inhibitor treatment, suggesting that FABS is associated with HBV particle production but not its genome replication. This suggests that FABS might be a potent target for anti-HBV drug with a mode of action different from current HBV therapy. -- Highlights: •Inhibitors of ACC1 and FAS but not SCD1 decreased production of extracellular HBV DNA. •Products of FABS, long chain fatty acids, increased production of extracellular HBV DNA. •FAS inhibitor increased intracellular levels of HBV DNA and HBcAg. •FABS was suggested to contribute to HBV particle production without significant relation with secretory pathway of the cells.

  15. New product development projects evaluation under time uncertainty

    Directory of Open Access Journals (Sweden)

    Thiago Augusto de Oliveira Silva

    2009-12-01

    Full Text Available The development time is one of the key factors that contribute to the new product development success. In spite of that, the impact of the time uncertainty on the development has been not fully exploited, as far as decision supporting models to evaluate this kind of projects is concerned. In this context, the objective of the present paper is to evaluate the development process of new technologies under time uncertainty. We introduce a model which captures this source of uncertainty and develop an algorithm to evaluate projects that incorporates Monte Carlo Simulation and Dynamic Programming. The novelty in our approach is to thoroughly blend the stochastic time with a formal approach to the problem, which preserves the Markov property. We base our model on the distinction between the decision epoch and the stochastic time. We discuss and illustrate the applicability of our model through an empirical example.O tempo de desenvolvimento é um dos fatores-chave que contribuem para o sucesso do desenvolvimento de novos produtos. Apesar disso, o impacto da incerteza de tempo no desenvolvimento tem sido pouco considerado em modelos de avaliação e valoração deste tipo de projetos. Neste contexto, este trabalho tem como objetivo avaliar projetos de desenvolvimento de novas tecnologias mediante o tempo incerto. Introduzimos um modelo capaz de captar esta fonte de incerteza e desenvolvemos um algoritmo para a valoração do projeto que integra Simulação de Monte Carlo e Programação Dinâmica. A novidade neste trabalho é conseguir integrar meticulosamente o tempo estocástico a uma estrutura formal para tomada de decisão que preserva a propriedade de Markov. O principal ponto para viabilizar este fato é distinção entre o momento de revisão e o tempo estocástico. Ilustramos e discutimos a aplicabilidade deste modelo por meio de um exemplo empírico.

  16. The impact of product experience, product involvement and verbal processing style on consumers' cognitive structure with regard to fresh fish

    DEFF Research Database (Denmark)

    Sørensen, Elin; Grunert, Klaus G.; Nielsen, Niels Asger

    1996-01-01

    central cognitive categories like values. A means-end chain consists of concrete product attributes, abstract product attributes, functional consequences, psychosocial consequences, instrumental values, a terminal values. 2) The most common method of measuring means-end chains has been the laddering...... interview technique. Laddering is a semi-qualitative technique which is open for the respondent's own answers without flooding the interviewer with data, as do other qualitative techniques. The results from the laddering interviews are coded and usually presented in a so-called hierarchical value map. 3...... were interviewed. Respondents were asked to rank four meat types, ie, (1) a fresh, whole, gutted plaice, (2) a package of frozen fish fillets, (3) a whole, frozen chicken, and (4) a package of fresh pork chops, according to how likely it would be that they would use them for a hot meal on a work...

  17. Eucalyptus ESTs involved in the production of 9-cis epoxycarotenoid dioxygenase, a regulatory enzyme of abscisic acid production

    Directory of Open Access Journals (Sweden)

    Iraê A. Guerrini

    2005-01-01

    Full Text Available Abscisic acid (ABA regulates stress responses in plants, and genomic tools can help us to understand the mechanisms involved in that process. FAPESP, a Brazilian research foundation, in association with four private forestry companies, has established the FORESTs database (https://forests.esalq.usp.br. A search was carried out in the Eucalyptus expressed sequence tag database to find ESTs involved with 9-cis epoxycarotenoid dioxygenase (NCED, the regulatory enzyme for ABA biosynthesis, using the basic local BLAST alignment tool. We found four clusters (EGEZLV2206B11.g, EGJMWD2252H08.g, EGBFRT3107F10.g, and EGEQFB1200H10.g, which represent similar sequences of the gene that produces NCED. Data showed that the EGBFRT3107F10.g cluster was similar to the maize (Zea mays NCED enzyme, while EGEZLV2206B11.g and EGJMWD2252H08.g clusters were similar to the avocado (Persea americana NCED enzyme. All Eucalyptus clusters were expressed in several tissues, especially in flower buds, where ABA has a special participation during the floral development process.

  18. Forming the face of green products : Mood boards and early consumer involvement in ship interior design

    NARCIS (Netherlands)

    Murto, P.; Ahola, M.; Person, F.E.O.K.

    2013-01-01

    In this paper, we study mood boards and the process by which they can be used to understand consumer inferences about environmental sustainability in the early stages of green product development. As a component of a research project on sustainable ship design, we created mood boards showcasing

  19. Involvement of Syk kinase in TNF-induced nitric oxide production by airway epithelial cells

    International Nuclear Information System (INIS)

    Ulanova, Marina; Marcet-Palacios, Marcelo; Munoz, Samira; Asfaha, Samuel; Kim, Moo-Kyung; Schreiber, Alan D.; Befus, A. Dean

    2006-01-01

    We have recently found that Syk is widely expressed in lung epithelial cells (EC) and participates in β1 integrin signaling. In this study, we assessed the role of Syk in regulation of NO production. Stimulation of human bronchial EC line HS-24 by TNF caused an increased expression of inducible nitric oxide synthase (iNOS). Inhibition of Syk using siRNA or piceatannol down-regulated the iNOS expression and reduced NO production. This effect occurred in EC simultaneously stimulated via β1 integrins, suggesting that TNF and β1 integrins provide co-stimulatory signals. Inhibition of Syk down-regulated TNF-induced p38 and p44/42 MAPK phosphorylation and nuclear translocation of p65 NF-κB. Thus, TNF-induced activation of pro-inflammatory signaling in EC leading to enhanced expression of iNOS and NO production was dependent on Syk. Syk-mediated signaling regulates NO production at least partly via activating the MAPK cascade. Understanding the role of Syk in airway EC may help in developing new therapeutic tools for inflammatory lung disorders

  20. The New Production of Users: Changing Innovation Collectives and Involvement Strategies

    NARCIS (Netherlands)

    Hyysalo, Sampsa; Jensen, Torben Elgaard; Oudshoorn, Nelly E.J.

    2016-01-01

    Behind the steady stream of new products, technologies, systems and services in our modern societies there is prolonged and complicated battle around the role of users. How should designers get to know the users’ interests and needs? Who should speak for the users? How may designers collaborate with

  1. Association between the time perspective and type of involvement in bullying among adolescents: A cross-sectional study in Japan.

    Science.gov (United States)

    Mizuta, Akiko; Okada, Eisaku; Nakamura, Mieko; Yamaguchi, Hisayoshi; Ojima, Toshiyuki

    2018-04-01

    To examine the association between the types of involvement in bullying and the time perspective among Japanese adolescents. A questionnaire was conducted among Japanese junior high school students at eight public schools that were located in two cities in Shizuoka Prefecture, Japan. Shirai's Experiential Time Perspective Scale was used, which comprises four subscales: goal-directedness, hopefulness, self-fulfillment, and acceptance of the past. An analysis of covariance was applied, with the time-perspective subscales as the objective variable, type of involvement in bullying as a fixed factor, and grade, family structure, and economic status as the covariates. The analysis sample included 2630 adolescents (valid response rate: 88.6%). The bullying rate of the boys was 10.8% and 4.1% for the girls, for the male victims it was 10.1% and 14.5% for the female victims, and for both the bully and the victim, it was 8.5% and 5.4%, respectively. The students who were not involved in bullying had the highest scores of hopefulness, self-fulfillment, and acceptance of the past. For both sexes, bullying was significantly associated with hopefulness, self-fulfillment, and acceptance of the past. Goal-directedness was not associated with the type of involvement in bullying. The victims of bullying had low time perspectives of hopefulness, self-fulfillment, and acceptance of the past. Providing support that increases hopefulness, self-fulfillment, and acceptance of the past might help to prevent pessimistic decision-making, such as that seen in cases of suicide. © 2017 Japan Academy of Nursing Science.

  2. Economic Evaluations for the Carbon Dioxide-involved Production of High-value Chemicals

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Ji Hyun; Lee, Dong Woog; Jang, Se Gyu; Kwak, No-Sang; Lee, In Young; Jang, Kyung Ryoung; Shim, Jae-Goo [KEPCO Research Institute, Daejon (Korea, Republic of); Choi, Jong Shin [Korea East-West Power Co. LTD, Seoul (Korea, Republic of)

    2014-06-15

    Economic evaluation of the manufacturing technology of high-value chemicals through the carbonation reaction of carbon dioxide contained in the flue gas was performed, and analysis of the IRR (Internal Rate of Return) and whole profit along the production plan of the final product was conducted. Through a carbonation reaction with sodium hydroxide that is generated from electrolysis and by using carbon dioxide in the combustion gas that is generated in the power plant, it is possible to get a high value products such as sodium bicarbonate compound and also to reduce the carbon dioxide emission simultaneously. The IRR (Internal Rate of Return) and NPV (Net Present Value) methods were used for the economic evaluation of the process which could handle carbon dioxide of 100 tons per day in the period of the 20 years of plant operation. The results of economic evaluation showed that the IRR of baseline case of technology was 67.2% and the profit that obtained during the whole operation period (20 years) was 346,922 million won based on NPV value. When considering ETS due to the emissions trading enforcement that will be activated in 2015, the NPV was improved to a 6,000 million won. Based on this results, it could be concluded that this CO2 carbonation technology is an cost-effective technology option for the reduction of greenhouse gas.

  3. Economic Evaluations for the Carbon Dioxide-involved Production of High-value Chemicals

    International Nuclear Information System (INIS)

    Lee, Ji Hyun; Lee, Dong Woog; Jang, Se Gyu; Kwak, No-Sang; Lee, In Young; Jang, Kyung Ryoung; Shim, Jae-Goo; Choi, Jong Shin

    2014-01-01

    Economic evaluation of the manufacturing technology of high-value chemicals through the carbonation reaction of carbon dioxide contained in the flue gas was performed, and analysis of the IRR (Internal Rate of Return) and whole profit along the production plan of the final product was conducted. Through a carbonation reaction with sodium hydroxide that is generated from electrolysis and by using carbon dioxide in the combustion gas that is generated in the power plant, it is possible to get a high value products such as sodium bicarbonate compound and also to reduce the carbon dioxide emission simultaneously. The IRR (Internal Rate of Return) and NPV (Net Present Value) methods were used for the economic evaluation of the process which could handle carbon dioxide of 100 tons per day in the period of the 20 years of plant operation. The results of economic evaluation showed that the IRR of baseline case of technology was 67.2% and the profit that obtained during the whole operation period (20 years) was 346,922 million won based on NPV value. When considering ETS due to the emissions trading enforcement that will be activated in 2015, the NPV was improved to a 6,000 million won. Based on this results, it could be concluded that this CO2 carbonation technology is an cost-effective technology option for the reduction of greenhouse gas

  4. The gene bap, involved in biofilm production, is present in Staphylococcus spp. strains from nosocomial infections.

    Science.gov (United States)

    Potter, Amina; Ceotto, Hilana; Giambiagi-Demarval, Marcia; dos Santos, Kátia Regina Netto; Nes, Ingolf F; Bastos, Maria do Carmo de Freire

    2009-06-01

    This study analyzed ten strains of coagulase-negative staphylococci (CNS) involved in nosocomial infections in three Brazilian hospitals. Their antibiotic susceptibility profile showed that most strains exhibited multiple antibiotic resistance and possessed the mecA gene. The ability of these strains to adhere to polystyrene microtiter plates was also tested and nine of them proved to be biofilm producers at least in one of the three conditions tested: growth in TSB, in TSB supplemented with NaCl, or in TSB supplemented with glucose. The presence of the bap gene, which codes for the biofilm-associated protein (Bap), was investigated in all ten strains by PCR. AU strains were bop-positive and DNA sequencing experiments confirmed that the fragments amplified were indeed part of a bap gene. The presence of the icaA gene, one of the genes involved in polysaccharide intercellular adhesin (PIA) formation, was also detected by PCR in eight of the ten strains tested. The two icaA-negative strains were either weak biofilm producer or no biofilm producer, although they were bop-positive. To our knowledge, this is the first report demonstrating the presence of the bap gene in nosocomial isolates of CNS, being also the first report on the presence of this gene in Staphylococcus haemolyticus and S. cohnii.

  5. Workload assessment on foundry SME to enhance productivity using full time equivalent

    Directory of Open Access Journals (Sweden)

    Sari Amarria Dila

    2018-01-01

    Full Text Available Aluminium SME aims to increase the production amount by producing wok as much as 300 Units. The problem is workload analysis of operator on the wok production line in the wok foundry SME as well as the production cycle-making cycle time and analyze the workload received by the operator when producing 300 woks using the full time equivalent (FTE method. This study aims to measure the workload of each division worker in the production process with a total of 13 workers observed. This study provides a work division recommendation based on the workload that has been carefully examined. This research involves percentage of workload effectiveness and the wages of workers. In lathe division have overload workload. While the printing division, melting inspection division, packaging and transportation division including normal workload category and the percentage of good work effectiveness. The result provides recommendations for the addition of 2 workers in each division that includes the category of overload of the lathe division with the number of initial workers as many as 13 workers to 15 workers. In the last stage perform a simulation by comparing the system of prefix work and proposal. The simulation results obtained with the initial work system to get an average of 223 woks / day. Meanwhile, for the proposed work system to get an average output of 291 woks.

  6. CONSUMER INVOLVEMENT AND BRAND SENSITIVITY OF UNIVERSITY STUDENTS IN THEIR CHOICE OF FASHION PRODUCTS

    OpenAIRE

    Ersun, A. Nur; Yıldırım, Figen

    2015-01-01

    The purpose of this study is to better understand the interest of university students in fashion products and to ascertain how different social variables explain variance in their brand sensitivity.Fashion happens to be a relevant and powerful force in our lives. At every level of society, people greatly care about the way they look, which affects both their self –esteem and the way other people interacr with them. For young adults wearing fashion brands seems to be a way of feeling adequate....

  7. The HP0256 gene product is involved in motility and cell envelope architecture of Helicobacter pylori

    LENUS (Irish Health Repository)

    Douillard, Francois P

    2010-04-08

    Abstract Background Helicobacter pylori is the causative agent for gastritis, and peptic and duodenal ulcers. The bacterium displays 5-6 polar sheathed flagella that are essential for colonisation and persistence in the gastric mucosa. The biochemistry and genetics of flagellar biogenesis in H. pylori has not been fully elucidated. Bioinformatics analysis suggested that the gene HP0256, annotated as hypothetical, was a FliJ homologue. In Salmonella, FliJ is a chaperone escort protein for FlgN and FliT, two proteins that themselves display chaperone activity for components of the hook, the rod and the filament. Results Ablation of the HP0256 gene in H. pylori significantly reduced motility. However, flagellin and hook protein synthesis was not affected in the HP0256 mutant. Transmission electron transmission microscopy revealed that the HP0256 mutant cells displayed a normal flagellum configuration, suggesting that HP0256 was not essential for assembly and polar localisation of the flagella in the cell. Interestingly, whole genome microarrays of an HP0256 mutant revealed transcriptional changes in a number of genes associated with the flagellar regulon and the cell envelope, such as outer membrane proteins and adhesins. Consistent with the array data, lack of the HP0256 gene significantly reduced adhesion and the inflammatory response in host cells. Conclusions We conclude that HP0256 is not a functional counterpart of FliJ in H. pylori. However, it is required for full motility and it is involved, possibly indirectly, in expression of outer membrane proteins and adhesins involved in pathogenesis and adhesion.

  8. Cyclin Y Is Involved in the Regulation of Adipogenesis and Lipid Production.

    Directory of Open Access Journals (Sweden)

    Weiwei An

    Full Text Available A new member of the cyclin family cyclin Y (CCNY is involved in the regulation of various physiological processes. In this study, the role of CCNY in energy metabolism was characterized. We found that compared with wild-type (WT mice, Ccny knockout (KO mice had both lower body weight and lower fat content. The Ccny KO mice also had a higher metabolic rate, resisted the stress of a high-fat diet, and were sensitive to calorie restriction. The expression levels of UCP1 and PGC1α were significantly higher in the brown adipose tissue (BAT of the Ccny KO mice than that of the WT littermate controls, whereas there was no significant difference in BAT weight between the WT and the Ccny KO mice. In addition, the down-regulation of Ccny resulted in suppression of white adipocyte differentiation both in vivo and in vitro, while the expression of Ccny was up-regulated by C/EBPα. Furthermore, both hepatocytes and HepG2 cells that were depleted of Ccny were insensitive to insulin stimulation, consistent with the significant inhibition of insulin sensitivity in the liver of the Ccny KO mice, but no significant changes in WAT and muscle, indicating that CCNY is involved in regulating the hepatic insulin signaling pathway. The hepatic insulin resistance generated by Ccny depletion resulted in down-regulation of the sterol-regulatory element-binding protein (SREBP1 and fatty acid synthase (FASN. Together, these results provide a new link between CCNY and lipid metabolism in mice, and suggest that inhibition of CCNY may offer a therapeutic approach to obesity and diabetes.

  9. Production trials involving use of the FAMACHA© system for haemonchosis in sheep : preliminary results

    Directory of Open Access Journals (Sweden)

    J.A. Van Wyk

    2008-09-01

    Full Text Available In three trials conducted on two separate farms the production of sheep treated for naturally acquired haemonchosis using the FAMACHA© system of targeted selective treatment (TST (i.e. to treat only those animals unable to manage unaided in the face of heavy Haemonchus challenge was compared to that of suppressively drenched sheep in the same flock. As expected by the research team who developed and evaluated the FAMACHA© system, TST did result in some loss in production. However, despite high levels of worm challenge in two of the trials and the fact that the comparison was with suppressive drenching which is not sustainable, the total effect was relatively small in relation to the important advantage of using the TST as regards reduced selection for anthelmintic resistance (AR. Concerning the sustainability of worm control, it is concluded that the development of drug resistance to anthelmintics leaves sheep and goat farmers in South Africa no choice but to use methods of TST such as FAMACHA©. The FAMACHA© system can also be a useful clinical aid for early on-farm detection of AR by farmers; the degree of improvement in the colour of the ocular mucous membrane from pale to red in individually drenched anaemic animals over a period of 7-14 days can give a good indication of the efficacy of the compound(s used.

  10. Bioethanol production involving recombinant C. thermocellum hydrolytic hemicellulase and fermentative microbes.

    Science.gov (United States)

    Das, Saprativ P; Ravindran, Rajeev; Ahmed, Shadab; Das, Debasish; Goyal, Dinesh; Fontes, Carlos M G A; Goyal, Arun

    2012-07-01

    The enhancement of the biomass productivity of Escherichia coli cells harbouring the truncated 903 bp gene designated as glycoside hydrolase family 43 (GH43) from Clostridium thermocellum showing hemicellulase activity along with its further use in simultaneous saccharification and fermentation (SSF) process is described. (Phosphoric acid) H(3)PO(4)-acetone treatment and ammonia fibre expansion (AFEX) were the pretreatment strategies employed on the leafy biomass of mango, poplar, neem and asoka among various substrates owing to their high hemicellulose content. GH43 showed optimal activity at a temperature of 50 °C, pH 5.4 with stability over a pH range of 5.0-6.2. A 4-fold escalation in growth of the recombinant E. coli cells was observed when grown using repeated batch strategy in LB medium supplemented with glucose as co-substrate. Candida shehatae utilizing pentose sugars was employed for bioethanol production. AFEX pretreatment proved to be better over acid-acetone technique. The maximum ethanol concentration (1.44 g/L) was achieved for AFEX pretreated mango (1%, w/v) followed by poplar with an ethanol titre (1.32 g/L) in shake flask experiments. A 1.5-fold increase in ethanol titre (2.11 g/L) was achieved with mango (1%, w/v) in a SSF process using a table top 2-L bioreactor with 1 L working volume.

  11. Effects of Time-Compressed Speech Training on Multiple Functional and Structural Neural Mechanisms Involving the Left Superior Temporal Gyrus.

    Science.gov (United States)

    Maruyama, Tsukasa; Takeuchi, Hikaru; Taki, Yasuyuki; Motoki, Kosuke; Jeong, Hyeonjeong; Kotozaki, Yuka; Nakagawa, Seishu; Nouchi, Rui; Iizuka, Kunio; Yokoyama, Ryoichi; Yamamoto, Yuki; Hanawa, Sugiko; Araki, Tsuyoshi; Sakaki, Kohei; Sasaki, Yukako; Magistro, Daniele; Kawashima, Ryuta

    2018-01-01

    Time-compressed speech is an artificial form of rapidly presented speech. Training with time-compressed speech (TCSSL) in a second language leads to adaptation toward TCSSL. Here, we newly investigated the effects of 4 weeks of training with TCSSL on diverse cognitive functions and neural systems using the fractional amplitude of spontaneous low-frequency fluctuations (fALFF), resting-state functional connectivity (RSFC) with the left superior temporal gyrus (STG), fractional anisotropy (FA), and regional gray matter volume (rGMV) of young adults by magnetic resonance imaging. There were no significant differences in change of performance of measures of cognitive functions or second language skills after training with TCSSL compared with that of the active control group. However, compared with the active control group, training with TCSSL was associated with increased fALFF, RSFC, and FA and decreased rGMV involving areas in the left STG. These results lacked evidence of a far transfer effect of time-compressed speech training on a wide range of cognitive functions and second language skills in young adults. However, these results demonstrated effects of time-compressed speech training on gray and white matter structures as well as on resting-state intrinsic activity and connectivity involving the left STG, which plays a key role in listening comprehension.

  12. Two Genomic Regions Involved in Catechol Siderophore Production by Erwinia carotovora

    Science.gov (United States)

    Bull, Carolee T.; Ishimaru, Carol A.; Loper, Joyce E.

    1994-01-01

    Two regions involved in catechol biosynthesis (cbs) of Erwinia carotovora W3C105 were cloned by functional complementation of Escherichia coli mutants that were deficient in the biosynthesis of the catechol siderophore enterobactin (ent). A 4.3-kb region of genomic DNA of E. carotovora complemented the entB402 mutation of E. coli. A second genomic region of 12.8 kb complemented entD, entC147, entE405, and entA403 mutations of E. coli. Although functions encoded by catechol biosynthesis genes (cbsA, cbsB, cbsC, cbsD, and cbsE) of E. carotovora were interchangeable with those encoded by corresponding enterobactin biosynthesis genes (entA, entB, entC, entD, and entE), only cbsE hybridized to its functional counterpart (entE) in E. coli. The cbsEA region of E. carotovora W3C105 hybridized to genomic DNA of 21 diverse strains of E. carotovora but did not hybridize to that of a chrysobactin-producing strain of Erwinia chrysanthemi. Strains of E. carotovora fell into nine groups on the basis of sizes of restriction fragments that hybridized to the cbsEA region, indicating that catechol biosynthesis genes were highly polymorphic among strains of E. carotovora. PMID:16349193

  13. Microbial communities involved in methane production from hydrocarbons in oil sands tailings.

    Science.gov (United States)

    Siddique, Tariq; Penner, Tara; Klassen, Jonathan; Nesbø, Camilla; Foght, Julia M

    2012-09-04

    Microbial metabolism of residual hydrocarbons, primarily short-chain n-alkanes and certain monoaromatic hydrocarbons, in oil sands tailings ponds produces large volumes of CH(4) in situ. We characterized the microbial communities involved in methanogenic biodegradation of whole naphtha (a bitumen extraction solvent) and its short-chain n-alkane (C(6)-C(10)) and BTEX (benzene, toluene, ethylbenzene, and xylenes) components using primary enrichment cultures derived from oil sands tailings. Clone libraries of bacterial 16S rRNA genes amplified from these enrichments showed increased proportions of two orders of Bacteria: Clostridiales and Syntrophobacterales, with Desulfotomaculum and Syntrophus/Smithella as the closest named relatives, respectively. In parallel archaeal clone libraries, sequences affiliated with cultivated acetoclastic methanogens (Methanosaetaceae) were enriched in cultures amended with n-alkanes, whereas hydrogenotrophic methanogens (Methanomicrobiales) were enriched with BTEX. Naphtha-amended cultures harbored a blend of these two archaeal communities. The results imply syntrophic oxidation of hydrocarbons in oil sands tailings, with the activities of different carbon flow pathways to CH(4) being influenced by the primary hydrocarbon substrate. These results have implications for predicting greenhouse gas emissions from oil sands tailings repositories.

  14. Active pharmaceutical ingredient (API) production involving continuous processes – A process system engineering (PSE)-assisted design framework

    DEFF Research Database (Denmark)

    Cervera Padrell, Albert Emili; Skovby, Tommy; Kiil, Søren

    2012-01-01

    and fermentation-based products. The method exploits the synergic combination of continuous flow technologies (e.g., microfluidic techniques) and process systems engineering (PSE) methods and tools for faster process design and increased process understanding throughout the whole drug product and process...... kg of product – was reduced to half of its initial value, with potential for further reduction. The case-study includes reaction steps typically used by the pharmaceutical industry featuring different characteristic reaction times, as well as L–L separation and distillation-based solvent exchange...

  15. Hopf bifurcations of a ratio-dependent predator–prey model involving two discrete maturation time delays

    International Nuclear Information System (INIS)

    Karaoglu, Esra; Merdan, Huseyin

    2014-01-01

    Highlights: • A ratio-dependent predator–prey system involving two discrete maturation time delays is studied. • Hopf bifurcations are analyzed by choosing delay parameters as bifurcation parameters. • When a delay parameter passes through a critical value, Hopf bifurcations occur. • The direction of bifurcation, the period and the stability of periodic solution are also obtained. - Abstract: In this paper we give a detailed Hopf bifurcation analysis of a ratio-dependent predator–prey system involving two different discrete delays. By analyzing the characteristic equation associated with the model, its linear stability is investigated. Choosing delay terms as bifurcation parameters the existence of Hopf bifurcations is demonstrated. Stability of the bifurcating periodic solutions is determined by using the center manifold theorem and the normal form theory introduced by Hassard et al. Furthermore, some of the bifurcation properties including direction, stability and period are given. Finally, theoretical results are supported by some numerical simulations

  16. Real Time Part Input Control of a Pull Production System by Finding IF-THEN Rules

    Science.gov (United States)

    Ramli, Rizauddin; Yamamoto, Hidehiko; Abu Qudeiri, Jaber

    This paper considers the part input problem of a production system where two Flexible Transfer Lines (FTLs) consisting of an up-stream production line and a down-stream production line while operating under Just In Time (JIT) production management. The up-stream production line processes the raw material after receiving them from suppliers, and after processing them, delivers the processed product to a down-stream production line via a conveyer. In this paper, we have proposed a novel idea for a part input real time control system, known as Algorithm for Real Time Control of Part Input Systems (ARTCOPS). The algorithm is useful when FTLs are in operation under a production order that is different from the pre-decided production schedule. Simulations of virtual production systems have been carried out to verify that ARTCOPS is useful in real time control, although the production orders are different from the pre-decided production scheduling.

  17. Involving Freight Transport Actors in Production of Knowledge - Experience with Future Workshop Methodology

    DEFF Research Database (Denmark)

    Jespersen, Per Homann; Drewes, Lise

    2005-01-01

    the experience and knowledge of actors in the freight transport sector are included directly in a scientific process in order to develop future and strategic studies. Future research is often produced as desktop research and presented as the results of scientists’ forecasting and scenario building...... in the format of a future workshop included freight transport stakeholders in the research process in order to produce knowledge meeting scientific quality criteria and at the same time in a form suitable for improving the problem solving capabilities of the participants....

  18. The Burkholderia cepacia rpoE gene is not involved in exopolysaccharide production and onion pathogenicity.

    Science.gov (United States)

    Devescovi, Giulia; Venturi, Vittorio

    2006-03-01

    Burkholderia cepacia was originally described as the causative agent of bacterial rot of onions, and it has now emerged as an important opportunistic pathogen causing severe chronic lung infections in patients having cystic fibrosis. Burkholderia cepacia is now classified into nine very closely related species (previously designated as genomovars), all of which have been isolated from both environmental and clinical sources and are collectively known as the B. cepacia complex. The alternative extracytoplasmic function sigma factor, sigmaE, has been determined in several bacterial species as making substantial contributions to bacterial survival under stress conditions. Here, we report the identification and characterization of the rpoE gene, encoding sigmaE, of B. cepacia. It is highly similar to sigmaE of other bacteria, including Escherichia coli and Pseudomonas aeruginosa. Studies using an rpoE knockout mutant of B. cepacia revealed that many stress adaptations, including osmotic, oxidative, desiccation, carbon, and nitrogen stress, were independent of sigmaE. Similarly, biofilm formation; production of exopolysaccharides, N-acyl homoserine lactones, and several exoenzymes; and onion pathogenicity were not affected by the absence of sigmaE. In contrast, sigmaE contributed to the adaptation to heat stress and phosphate starvation.

  19. Bioethanol production from leafy biomass of mango (Mangifera indica) involving naturally isolated and recombinant enzymes.

    Science.gov (United States)

    Das, Saprativ P; Ravindran, Rajeev; Deka, Deepmoni; Jawed, Mohammad; Das, Debasish; Goyal, Arun

    2013-01-01

    The present study describes the usage of dried leafy biomass of mango (Mangifera indica) containing 26.3% (w/w) cellulose, 54.4% (w/w) hemicellulose, and 16.9% (w/w) lignin, as a substrate for bioethanol production from Zymomonas mobilis and Candida shehatae. The substrate was subjected to two different pretreatment strategies, namely, wet oxidation and an organosolv process. An ethanol concentration (1.21 g/L) was obtained with Z. mobilis in a shake-flask simultaneous saccharification and fermentation (SSF) trial using 1% (w/v) wet oxidation pretreated mango leaves along with mixed enzymatic consortium of Bacillus subtilis cellulase and recombinant hemicellulase (GH43), whereas C. shehatae gave a slightly higher (8%) ethanol titer of 1.31 g/L. Employing 1% (w/v) organosolv pretreated mango leaves and using Z. mobilis and C. shehatae separately in the SSF, the ethanol titers of 1.33 g/L and 1.52 g/L, respectively, were obtained. The SSF experiments performed with 5% (w/v) organosolv-pretreated substrate along with C. shehatae as fermentative organism gave a significantly enhanced ethanol titer value of 8.11 g/L using the shake flask and 12.33 g/L at the bioreactor level. From the bioreactor, 94.4% (v/v) ethanol was recovered by rotary evaporator with 21% purification efficiency.

  20. Transcriptional regulation of genes involved in terpenoid índole alkaloid production in Catharanthus roseus seedlings

    Directory of Open Access Journals (Sweden)

    Pedro J. Rocha

    2002-07-01

    Full Text Available Catharanthus roseus (L. G Don is a medicinal plant that produces a variety of terpenoid indole alkaloids (TIAs, some of which display pharmacological activity. C. roseus plants and cell cultures have been used to elucidate the TIAs biosynthetic pathway. A considerable number or enzymes have also been characterised, and their respective genes cloned. TIAs production in C. roseus plant and cell cultures is highly regulated at transcriptional-, develop-mental-, and environmental-level. Studies into TIAs biosynthetic gene regulation have been carried out using cell cultures. However, regulation in plants is almost unknown. Here, biosynthetic genes idc, strl, d4h and dat expres-sion levels are qualitatively examined in a developmental series of C. roseus seedlings. The effect of water- and light-stress and methyl jasmonate (MeJa and acetyl salicylic acid (ASA elicitation is also examined. Comparison between seedlings and cell cultures strongly suggests that TIAs biosynthetic gene transcriptional regulation is different in C.roseus plants and cell cultures.

  1. Space-time dependence between energy sources and climate related energy production

    Science.gov (United States)

    Engeland, Kolbjorn; Borga, Marco; Creutin, Jean-Dominique; Ramos, Maria-Helena; Tøfte, Lena; Warland, Geir

    2014-05-01

    and solar power production and their co-fluctuation at small time scales. The multi-scale nature of the variability is less studied, i.e., the potential adverse or favorable co-fluctuation at intermediate time scales involving water scarcity or abundance, is less present in the literature.Our review points out that it could be especially interesting to promote research on how the pronounced large-scale fluctuations in inflow to hydropower (intra-annual run-off) and smaller scale fluctuations in wind- and solar-power interact in an energy system. There is a need to better represent the profound difference between wind-, solar- and hydro-energy sources. On the one hand, they are all directly linked to the 2-D horizontal dynamics of meteorology. On the other hand, the branching structure of hydrological systems transforms this variability and governs the complex combination of natural inflows and reservoir storage.Finally, we note that the CRE production is, in addition to weather, also influenced by the energy system and market, i.e., the energy transport and demand across scales as well as changes of market regulation. The CRE production system lies thus in this nexus between climate, energy systems and market regulations. The work presented is part of the FP7 project COMPLEX (Knowledge based climate mitigation systems for a low carbon economy; http://www.complex.ac.uk)

  2. Consumer Attitudes Toward Advertisement and Brand, Based on the Number of Endorsers and Product Involvement: An Experimental Study

    Directory of Open Access Journals (Sweden)

    Tanti Handriana

    2017-12-01

    Full Text Available Utilizing endorsers in the advertising industry to promote products is currently on the rise, and employing celebrities as the endorsers is still the marketers’ favorite method. This study aims to analyze the influence of the number of endorsers and the product’s involvement on the consumers’ attitude towards the advertisement and the brand. The research’s approach used a 2x2 factorial experimental design. A total of 120 undergraduate students, who were further divided into 4 groups, were selected as the respondents of this study. The results show the differences in consumer attitudes towards advertisements and the brand, based on the number of endorsers and the product’s involvement. The study also reveals that if there is low involvement with the product, multiple celebrity endorsements will generate a better consumers’ attitude towards it than a single celebrity endorsement. Multiple celebrity endorsements will also generate a better attitude among the consumers towards the brand than a single celebrity endorsement will produce.

  3. Are part-time workers less productive and underpaid?

    OpenAIRE

    Garnero, Andrea

    2016-01-01

    About one in five workers across OECD countries is employed part-time, and the share has been steadily increasing since the beginning of the economic and financial crisis in 2007. Part-time options play an important economic role by providing more flexible working arrangements for both workers and firms. Part-time employment has also contributed substantially to increasing the employment rate, especially among women. However, part-time work comes at a cost of lower wages for workers, mainly b...

  4. Deletion of genes involved in glutamate metabolism to improve poly-gamma-glutamic acid production in B. amyloliquefaciens LL3.

    Science.gov (United States)

    Zhang, Wei; He, Yulian; Gao, Weixia; Feng, Jun; Cao, Mingfeng; Yang, Chao; Song, Cunjiang; Wang, Shufang

    2015-02-01

    Here, we attempted to elevate poly-gamma-glutamic acid (γ-PGA) production by modifying genes involved in glutamate metabolism in Bacillus amyloliquefaciens LL3. Products of rocR, rocG and gudB facilitate the conversion from glutamate to 2-oxoglutarate in Bacillus subtillis. The gene odhA is responsible for the synthesis of a component of the 2-oxoglutarate dehydrogenase complex that catalyzes the oxidative decarboxylation of 2-oxoglutarate to succinyl coenzyme A. In-frame deletions of these four genes were performed. In shake flask experiments the gudB/rocG double mutant presented enhanced production of γ-PGA, a 38 % increase compared with wild type. When fermented in a 5-L fermenter with pH control, the γ-PGA yield of the rocR mutant was increased to 5.83 g/L from 4.55 g/L for shake flask experiments. The gudB/rocG double mutant produced 5.68 g/L γ-PGA compared with that of 4.03 g/L for the wild type, a 40 % increase. Those results indicated the possibility of improving γ-PGA production by modifying glutamate metabolism, and identified potential genetic targets to improve γ-PGA production.

  5. The optimal production-run time for a stock-dependent imperfect production process

    Directory of Open Access Journals (Sweden)

    Jain Divya

    2013-01-01

    Full Text Available This paper develops an inventory model for a hypothesized volume flexible manufacturing system in which the production rate is stock-dependent and the system produces both perfect and imperfect quality items. The demand rate of perfect quality items is known and constant, whereas the demand rate of imperfect (non-conforming to specifications quality items is a function of discount offered in the selling price. In this paper, we determine an optimal production-run time and the optimal discount that should be offered in the selling price to influence the sale of imperfect quality items produced by the manufacturing system. The considered model aims to maximize the net profit obtained through the sales of both perfect and imperfect quality items subject to certain constraints of the system. The solution procedure suggests the use of ‘Interior Penalty Function Method’ to solve the associated constrained maximization problem. Finally, a numerical example demonstrating the applicability of proposed model has been included.

  6. Cycle for fuel elements. Uranium production, programs for nuclear power stations and capital expenditure involved

    International Nuclear Information System (INIS)

    Andriot, J.; Gaussens, J.

    1958-01-01

    A number of different possible programs for nuclear power stations of various types are presented in this survey. These programs are established in relation to the use of uranium and thorium in amounts similar to those that shall probably be produced in France during the next fifteen years. As it is possible to draw plans for nuclear power stations in which several processes exist simultaneously, an unlimited number of variations being thinkable, this survey is limited to successive analysis of the results obtained by use of only one of each of the following three systems: - system natural uranium-graphite, - system natural uranium-heavy water, -system enriched uranium-pressurised light water. All schemes are considered as assemblages of these three simple systems. The effects of plutonium recycling are also considered for each system. The electric power installed and the capacity of stations situated up-stream and down-stream have been calculated by this method and an attempt has been made to establish the sum to be invested during the fifteen years necessary for the launching of the programs scheduled. A table of timing for the investments groups the results obtained. Considering the fact that French availabilities in capital shall not be unlimited during the coming years, this way of presenting the results seems to be interesting. (author) [fr

  7. Different frontal involvement in ALS and PLS revealed by Stroop event-related potentials and reaction times

    Directory of Open Access Journals (Sweden)

    Ninfa eAmato

    2013-12-01

    Full Text Available BACKGROUND: A growing body of evidence suggests a link between cognitive and pathological changes in amyotrophic lateral sclerosis (ALS and in frontotemporal lobar dementia (FTLD. Cognitive deficits have been investigated much less extensively in primary lateral sclerosis (PLS than in ALS. OBJECTIVE: to investigate bioelectrical activity to Stroop test, assessing frontal function, in ALS, PLS and control groups. METHODS: 32 non-demented ALS patients, 10 non-demented PLS patients and 27 healthy subjects were included. Twenty-nine electroencephalography (EEG channels with binaural reference were recorded during covert Stroop task performance, involving mental discrimination of the stimuli and not vocal or motor response. Group effects on event related potentials (ERPs latency were analyzed using statistical multivariate analysis. Topographic analysis was performed using low resolution brain electromagnetic tomography (LORETA. RESULTS: ALS patients committed more errors in the execution of the task but they were not slower, whereas PLS patients did not show reduced accuracy, despite a slowing of reaction times (RTs. The main ERP components were delayed in ALS, but not in PLS, compared with controls. Moreover, RTs speed but not ERP latency correlated with clinical scores. ALS had decreased frontotemporal activity in the P2, P3 and N4 time windows compared to controls. CONCLUSION: These findings suggest a different pattern of psychophysiological involvement in ALS compared with PLS. The former is increasingly recognized to be a multisystems disorder, with a spectrum of executive and behavioural impairments reflecting frontotemporal dysfunction. The latter seems to mainly involve the motor system, with largely spared cognitive functions. Moreover, our results suggest that the covert version of the Stroop task used in the present study, may be useful to assess cognitive state in the very advanced stage of the disease, when other cognitive tasks are not

  8. Multivariate Time Series Analysis for Optimum Production Forecast ...

    African Journals Online (AJOL)

    FIRST LADY

    (Amstrong, 1994, Bates, 1969, Newbold and Granger, 1974 and Whinkler and Makridakis ... distinct, essential components of inventory management while the random production is first ... To achieve this goal, model parameters are estimated or ... important regression model in forecasting of that nature, hence this study.

  9. Liver upregulation of genes involved in cortisol production and action is associated with metabolic syndrome in morbidly obese patients.

    Science.gov (United States)

    Torrecilla, Esther; Fernández-Vázquez, Gumersindo; Vicent, David; Sánchez-Franco, Franco; Barabash, Ana; Cabrerizo, Lucio; Sánchez-Pernaute, Andrés; Torres, Antonio J; Rubio, Miguel Angel

    2012-03-01

    Hepatic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which converts cortisone (inactive) to cortisol, is downregulated in obesity. However, this compensation fails in obese with metabolic abnormalities, such as diabetes. To further characterize the tissue-specific cortisol regeneration in obesity, we have investigated the mRNA expression of genes related to local cortisol production, i.e., 11β-HSD1, hexose-6-phosphate dehydrogenase (H6PDH) and cortisol action, glucocorticoid receptor (GR) and a cortisol target gene, phosphoenolpyruvate carboxykinase (PEPCK) in the liver, and visceral (VAT) and subcutaneous (SAT) adipose tissues from morbidly obese patients with and without metabolic syndrome (MS). Fifty morbidly obese patients undergoing bariatric surgery, 14 men (mean age, 41.3 ± 3.5 years; BMI, 48.0 ± 3.6 kg/m(2)) and 36 women (mean age, 44.6 ± 1.9 years; BMI, 44.9 ± 1.2 kg/m(2)), were classified as having MS (MS+, n = 20) or not (MS-, n = 30). Tissue mRNA levels were measured by real-time polymerase chain reaction. Hepatic mRNA levels of these genes were higher in obese patients with MS (11β-HSD1, P = 0.002; H6PDH, P = 0.043; GR, P = 0.033; PEPCK, P = 0.032) and positively correlated with the number of clinical characteristics that define the MS. The expression of the four genes positively correlated among them. In contrast to the liver, these genes were not differently expressed in VAT or SAT, when MS+ and MS- obese patients were compared. Coordinated liver-specific upregulation of genes involved in local cortisol regeneration and action support the concept that local hepatic hypercortisolism contributes to development of MS in morbidly obese patients.

  10. The problem of the involvement of the off-balance reserves of the metallic ores into the production process

    Directory of Open Access Journals (Sweden)

    V. I. Golik

    2017-12-01

    Full Text Available The underground mining of the ore deposits by means of the intensive methods of the traditional technologies is characterized by the loss of the reserves, which are off-balance for the technologies applied. The experience, which was accumulated by the state-of-the-art enterprises before the economic reforms and the crisis indicates, that it is possible to decrease the loss of metals. This can be assumed by means of involving the off-balance reserves into the production process with the metal lixiviation during closed work. The purpose of the present-day research is the substantiation of the technical possibility and economic reasonability of the lixiviation of metals from the off-balance reserves and poorly balance ores. The correct estimation of the perspectives of those combined technology is still one of the purposes. It is a matter of fact that combining traditional technologies of the underground mining with new ones concerned with the creation of the effective lixiviation of metals from ores can be carried out with the two-stage processing. It happens when the excavation of some amount of the balance reserves creates the compensational space for crushing off-balance reserves. Involving off-balance ores into the production process solves a set of the mining production problems. For example, the fullness of mineral resources usage, the strengthening of the resource base, the reduction of load of the environment and the security of works. The involvement of the off-balance reserves into the development in the course of the revaluation of the resources and in the technological facilities of the development in the context of the growth of the scale of production reduces the production price to the competitive level. The field of application of these results is in the mining enterprises which extract solid metal-containing ores by means of the underground mining. These ores are mostly of the nonferrous, rare and precious metals, which are easily

  11. Trace Metal Requirements for Microbial Enzymes Involved in the Production and Consumption of Methane and Nitrous Oxide

    Science.gov (United States)

    Glass, Jennifer B.; Orphan, Victoria J.

    2011-01-01

    Fluxes of greenhouse gases to the atmosphere are heavily influenced by microbiological activity. Microbial enzymes involved in the production and consumption of greenhouse gases often contain metal cofactors. While extensive research has examined the influence of Fe bioavailability on microbial CO2 cycling, fewer studies have explored metal requirements for microbial production and consumption of the second- and third-most abundant greenhouse gases, methane (CH4), and nitrous oxide (N2O). Here we review the current state of biochemical, physiological, and environmental research on transition metal requirements for microbial CH4 and N2O cycling. Methanogenic archaea require large amounts of Fe, Ni, and Co (and some Mo/W and Zn). Low bioavailability of Fe, Ni, and Co limits methanogenesis in pure and mixed cultures and environmental studies. Anaerobic methane oxidation by anaerobic methanotrophic archaea (ANME) likely occurs via reverse methanogenesis since ANME possess most of the enzymes in the methanogenic pathway. Aerobic CH4 oxidation uses Cu or Fe for the first step depending on Cu availability, and additional Fe, Cu, and Mo for later steps. N2O production via classical anaerobic denitrification is primarily Fe-based, whereas aerobic pathways (nitrifier denitrification and archaeal ammonia oxidation) require Cu in addition to, or possibly in place of, Fe. Genes encoding the Cu-containing N2O reductase, the only known enzyme capable of microbial N2O conversion to N2, have only been found in classical denitrifiers. Accumulation of N2O due to low Cu has been observed in pure cultures and a lake ecosystem, but not in marine systems. Future research is needed on metalloenzymes involved in the production of N2O by enrichment cultures of ammonia oxidizing archaea, biological mechanisms for scavenging scarce metals, and possible links between metal bioavailability and greenhouse gas fluxes in anaerobic environments where metals may be limiting due to sulfide

  12. Functional Characterization of NAC and MYB Transcription Factors Involved in Regulation of Biomass Production in Switchgrass (Panicum virgatum.

    Directory of Open Access Journals (Sweden)

    Ruiqin Zhong

    Full Text Available Switchgrass is a promising biofuel feedstock due to its high biomass production and low agronomic input requirements. Because the bulk of switchgrass biomass used for biofuel production is lignocellulosic secondary walls, studies on secondary wall biosynthesis and its transcriptional regulation are imperative for designing strategies for genetic improvement of biomass production in switchgrass. Here, we report the identification and functional characterization of a group of switchgrass transcription factors, including several NACs (PvSWNs and a MYB (PvMYB46A, for their involvement in regulating secondary wall biosynthesis. PvSWNs and PvMYB46A were found to be highly expressed in stems and their expression was closely associated with sclerenchyma cells. Overexpression of PvSWNs and PvMYB46A in Arabidopsis was shown to result in activation of the biosynthetic genes for cellulose, xylan and lignin and ectopic deposition of secondary walls in normally parenchymatous cells. Transactivation and complementation studies demonstrated that PvSWNs were able to activate the SNBE-driven GUS reporter gene and effectively rescue the secondary wall defects in the Arabidopsis snd1 nst1 double mutant, indicating that they are functional orthologs of Arabidopsis SWNs. Furthermore, we showed that PvMYB46A could activate the SMRE-driven GUS reporter gene and complement the Arabidopsis myb46 myb83 double mutant, suggesting that it is a functional ortholog of Arabidopsis MYB46/MYB83. Together, these results indicate that PvSWNs and PvMYB46A are transcriptional switches involved in regulating secondary wall biosynthesis, which provides molecular tools for genetic manipulation of biomass production in switchgrass.

  13. Cofactor and CO2 donor regulation involved in reductive routes for polymalic acid production by Aureobasidium pullulans CCTCC M2012223.

    Science.gov (United States)

    Zou, Xiang; Tu, Guangwei; Zan, Zhanquan

    2014-10-01

    Polymalic acid (PMA) is a water-soluble polyester with many attractive properties for biomedical application. Its monomer L-malic acid is widely used in the food industry and also a potential C4 platform chemical. Cofactor and CO2 donor involved in the reductive routes were investigated for PMA production by Aureobasidium pullulans. Biotin as the key cofactor of pyruvate carboxylase was favor for the PMA biosynthesis. Na2CO3 as CO2 donor can obviously improved PMA titer when compared with no CO2 supplier NaOH, and also exhibit more advantages than the other donor CaCO3 because of its water-soluble characteristic. A combinational process with addition of biotin 70 mg/L and Na2CO3 as the CO2 donor was scaled-up in 50 L fermentor, achieving the high product 34.3 g/L of PMA and productivity of 0.41 g/L h. This process provides an efficient and economical way for PMA and malic acid production, and is promising for industrial application.

  14. Future enhancements to 3D printing and real time production

    Science.gov (United States)

    Landa, Joseph; Jenkins, Jeffery; Wu, Jerry; Szu, Harold

    2014-05-01

    The cost and scope of additive printing machines range from several hundred to hundreds of thousands of dollars. For the extra money, one can get improvements in build size, selection of material properties, resolution, and consistency. However, temperature control during build and fusing predicts outcome and protects the IP by large high cost machines. Support material options determine geometries that can be accomplished which drives cost and complexity of printing heads. Historically, 3D printers have been used for design and prototyping efforts. Recent advances and cost reduction sparked new interest in developing printed products and consumables such as NASA who is printing food, printing consumer parts (e.g. cell phone cases, novelty toys), making tools and fixtures in manufacturing, and recursively print a self-similar printer (c.f. makerbot). There is a near term promise of the capability to print on demand products at the home or office... directly from the printer to use.

  15. Transcriptome and Gene Ontology (GO) Enrichment Analysis Reveals Genes Involved in Biotin Metabolism That Affect L-Lysine Production in Corynebacterium glutamicum.

    Science.gov (United States)

    Kim, Hong-Il; Kim, Jong-Hyeon; Park, Young-Jin

    2016-03-09

    Corynebacterium glutamicum is widely used for amino acid production. In the present study, 543 genes showed a significant change in their mRNA expression levels in L-lysine-producing C. glutamicum ATCC21300 than that in the wild-type C. glutamicum ATCC13032. Among these 543 differentially expressed genes (DEGs), 28 genes were up- or downregulated. In addition, 454 DEGs were functionally enriched and categorized based on BLAST sequence homologies and gene ontology (GO) annotations using the Blast2GO software. Interestingly, NCgl0071 (bioB, encoding biotin synthase) was expressed at levels ~20-fold higher in the L-lysine-producing ATCC21300 strain than that in the wild-type ATCC13032 strain. Five other genes involved in biotin metabolism or transport--NCgl2515 (bioA, encoding adenosylmethionine-8-amino-7-oxononanoate aminotransferase), NCgl2516 (bioD, encoding dithiobiotin synthetase), NCgl1883, NCgl1884, and NCgl1885--were also expressed at significantly higher levels in the L-lysine-producing ATCC21300 strain than that in the wild-type ATCC13032 strain, which we determined using both next-generation RNA sequencing and quantitative real-time PCR analysis. When we disrupted the bioB gene in C. glutamicum ATCC21300, L-lysine production decreased by approximately 76%, and the three genes involved in biotin transport (NCgl1883, NCgl1884, and NCgl1885) were significantly downregulated. These results will be helpful to improve our understanding of C. glutamicum for industrial amino acid production.

  16. Time-dependent histamine release from stored human blood products

    DEFF Research Database (Denmark)

    Nielsen, Hans Jørgen; Edvardsen, L; Vangsgaard, K

    1996-01-01

    .0 (range 176.0-910.0) nmol/l in whole blood and 475.0 (range 360.0-1560.0) nmol/l in plasma-reduced whole blood, while it was undetectable in SAGM blood. Spontaneous histamine release increased in a time-dependent manner from a median of 6.7 (range 2.2-17.4) nmol/l at the time of storage to 175.0 (range 33...

  17. Productions of invisible: considerations about time and training of teachers

    Directory of Open Access Journals (Sweden)

    Alice Dalmaso

    2013-01-01

    Full Text Available This paper aims to approach, even though in a briefly way, the subject of invention in the training of teachers. In order to do this, we will make a brief overview on Virgínia Kastrup contributions about this issue. One of the questions is the time - through Henri Bergson’s duration concept and its using in training theme. From this point, we will try to deconstruct a view about the identity reference in contemporaneity toward to multiple and open ways of existence. In the inventive movements of the processuality, the time is considered as an expression of human being individuation. It means to last refer to an immediacy of being, of being time, which are modulable and mutant, always in a creation process. In a movement of building a body which leaves an identity reference – that is opposite of self-transformation – necessarily we report us to the relation between the idea of time as duration and the individuation principle by Gilberto Simondon. With these concepts and their possible resonance in the discussion about formative politics, we can develop a view over the invisible to training of teachers and over the learners and another ways of operating in the world. The invention as a lever direct us to a field of possibilities to conceive and experience another time (and space which is producer of subjectivity, singularities and differences.

  18. Managing product complexity: It`s just a matter of time

    Energy Technology Data Exchange (ETDEWEB)

    Hinckley, C.M.

    1998-06-01

    It has long been the goal of designers to identify a robust measure of product complexity to guide product decisions. Using Design for Assembly evaluations from over 225 assemblies and subassemblies, alternative measures of product complexity are identified and compared. Time is shown to be the most consistently predicted, useful, and fungible measure. The distribution of assembly times for a product can be modeled by Pareto`s law. This leads to a new, more effective product design guideline and a predictive tool that enables rapid and accurate prediction of assembly times for redesigned products without having to repeat DFMA analysis.

  19. Reaction Time of Motor Responses in Two-Stimulus Paradigms Involving Deception and Congruity with Varying Levels of Difficulty

    Directory of Open Access Journals (Sweden)

    Jennifer M. C. Vendemia

    2005-01-01

    Full Text Available Deception research has focused on identifying peripheral nervous system markers while ignoring cognitive mechanisms underlying those markers. Cognitive theorists argue that the process of deception may involve such constructs as attentional capture, working memory load, or perceived incongruity with memory, while psychophysiologists argue for stimulus salience, arousal, and emotion. Three studies were conducted to assess reaction time (RT in relation to deception, response congruity, and preparedness to deceive. Similar to a semantic verification task, participants evaluated sentences that were either true or false, and then made truthful or deceptive evaluations of the sentence’s base truth-value. Findings indicate that deceptive responses have a longer RT than truthful responses, and that this relationship remains constant across response type and preparedness to deceive. The authors use these findings in preliminary support of a comprehensive cognitive model of deception.

  20. The productivity and cost-efficiency of models for involving nurse practitioners in primary care: a perspective from queueing analysis.

    Science.gov (United States)

    Liu, Nan; D'Aunno, Thomas

    2012-04-01

    To develop simple stylized models for evaluating the productivity and cost-efficiencies of different practice models to involve nurse practitioners (NPs) in primary care, and in particular to generate insights on what affects the performance of these models and how. The productivity of a practice model is defined as the maximum number of patients that can be accounted for by the model under a given timeliness-to-care requirement; cost-efficiency is measured by the corresponding annual cost per patient in that model. Appropriate queueing analysis is conducted to generate formulas and values for these two performance measures. Model parameters for the analysis are extracted from the previous literature and survey reports. Sensitivity analysis is conducted to investigate the model performance under different scenarios and to verify the robustness of findings. Employing an NP, whose salary is usually lower than a primary care physician, may not be cost-efficient, in particular when the NP's capacity is underutilized. Besides provider service rates, workload allocation among providers is one of the most important determinants for the cost-efficiency of a practice model involving NPs. Capacity pooling among providers could be a helpful strategy to improve efficiency in care delivery. The productivity and cost-efficiency of a practice model depend heavily on how providers organize their work and a variety of other factors related to the practice environment. Queueing theory provides useful tools to take into account these factors in making strategic decisions on staffing and panel size selection for a practice model. © Health Research and Educational Trust.

  1. Joint optimization of economic production quantity and preventive maintenance with considering multi-products and reserve time

    International Nuclear Information System (INIS)

    Liu, Xuejuan; Wang, Binrong

    2017-01-01

    Purpose: We deal with the problem of the joint determination of optimal economic production quantity (EPQ) and optimal preventive maintenance (PM) for a system that can produce multiple products alternately. The objective is to find the optimal number of production cycles and the PM policy simultaneously by minimizing the cost model. Design/methodology/approach: Considering the products go through the system in a sequence and a complete run of all products forms a production cycle. In each cycle, beyond production time we also consider some reserve time for maintenance and setup, shortage and overproduction may occur. We study the integrated problem based on two PM policies, and explain the situation with the other PM policies. The delay – time concept is used to model PM decisions. Findings: Using the integrated EPQ and PM model, we can calculate the optimal production planning and PM schedule simultaneously, especially we consider multiple products in each production cycle, which is more practical and economic than previous works. Originality/value: In modern companies, the production planning and maintenance schedule share the same system, and traditional research about two activities is separated, that always generate conflicts, such as inadequate or excessive maintenance, and shortages, etc., so we develop the integrated EPQ and PM model to avoid these undesirable effects.

  2. Joint optimization of economic production quantity and preventive maintenance with considering multi-products and reserve time

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xuejuan; Wang, Binrong

    2017-07-01

    Purpose: We deal with the problem of the joint determination of optimal economic production quantity (EPQ) and optimal preventive maintenance (PM) for a system that can produce multiple products alternately. The objective is to find the optimal number of production cycles and the PM policy simultaneously by minimizing the cost model. Design/methodology/approach: Considering the products go through the system in a sequence and a complete run of all products forms a production cycle. In each cycle, beyond production time we also consider some reserve time for maintenance and setup, shortage and overproduction may occur. We study the integrated problem based on two PM policies, and explain the situation with the other PM policies. The delay – time concept is used to model PM decisions. Findings: Using the integrated EPQ and PM model, we can calculate the optimal production planning and PM schedule simultaneously, especially we consider multiple products in each production cycle, which is more practical and economic than previous works. Originality/value: In modern companies, the production planning and maintenance schedule share the same system, and traditional research about two activities is separated, that always generate conflicts, such as inadequate or excessive maintenance, and shortages, etc., so we develop the integrated EPQ and PM model to avoid these undesirable effects.

  3. Wireless Time Tracking Improves Productivity at CSU Long Beach.

    Science.gov (United States)

    Charmack, Scott; Walsh, Randy

    2002-01-01

    Describes California State University Long Beach's implementation of new maintenance management software, which integrated maintenance, inventory control, and key control and allows technicians to enter and receive information through handheld wireless devices for more accurate time accounting. The school estimates a 10 percent increase in…

  4. The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production.

    Science.gov (United States)

    Aerts, David; Hauer, Esther E; Ohm, Robin A; Arentshorst, Mark; Teertstra, Wieke R; Phippen, Christopher; Ram, Arthur F J; Frisvad, Jens C; Wösten, Han A B

    2018-03-01

    Aspergillus niger secretes proteins throughout the colony except for the zone that forms asexual spores called conidia. Inactivation of flbA that encodes a regulator of G-protein signaling results in colonies that are unable to reproduce asexually and that secrete proteins throughout the mycelium. In addition, the ΔflbA strain shows cell lysis and has thinner cell walls. Expression analysis showed that 38 predicted transcription factor genes are differentially expressed in strain ΔflbA. Here, the most down-regulated predicted transcription factor gene, called fum21, was inactivated. Growth, conidiation, and protein secretion were not affected in strain Δfum21. Whole genome expression analysis revealed that 63 and 11 genes were down- and up-regulated in Δfum21, respectively, when compared to the wild-type strain. Notably, 24 genes predicted to be involved in secondary metabolism were down-regulated in Δfum21, including 10 out of 12 genes of the fumonisin cluster. This was accompanied by absence of fumonisin production in the deletion strain and a 25% reduction in production of pyranonigrin A. Together, these results link FlbA-mediated sporulation-inhibited secretion with mycotoxin production.

  5. Detecting Chaos from Agricultural Product Price Time Series

    Directory of Open Access Journals (Sweden)

    Xin Su

    2014-12-01

    Full Text Available Analysis of the characteristics of agricultural product price volatility and trend forecasting are necessary to formulate and implement agricultural price control policies. Taking wholesale cabbage prices as an example, a multiple test methodology has been adopted to identify the nonlinearity, fractality, and chaos of the data. The approaches used include the R/S analysis, the BDS test, the power spectra, the recurrence plot, the largest Lyapunov exponent, the Kolmogorov entropy, and the correlation dimension. The results show that there is chaos in agricultural wholesale price data, which provides a good theoretical basis for selecting reasonable forecasting models as prediction techniques based on chaos theory can be applied to forecasting agricultural prices.

  6. Time-resolved production and detection of reactive atoms

    International Nuclear Information System (INIS)

    Grossman, L.W.; Hurst, G.S.

    1977-09-01

    Cesium iodide in the presence of a buffer gas was dissociated with a pulsed ultraviolet laser, which will be referred to as the source laser. This created a population of atoms at a well defined time and in a compact, well defined volume. A second pulsed laser, with a beam that completely surrounded that of the first, photoionized the cesium after a known time delay. This laser will be referred to as the detector laser. It was determined that for short time delays, all of the cesium atoms were easily ionized. When focused, the source laser generated an extremely intense fluence. By accounting for the beam intensity profile it was shown that all of the molecules in the central portion of the beam can be dissociated and detected. Besides proving the feasibility of single-molecule detection, this enabled a determination of the absolute photodissociation cross section as a function of wavelength. Initial studies of the time decay of the cesium signal at low argon pressures indicated a non-exponential decay. This was consistent with a diffusion mechanism transporting cesium atoms out of the laser beam. Therefore, it was desired to conduct further experiments using a tightly focused source beam, passing along the axis of the detector beam. The theoretical behavior of this simple geometry accounting for diffusion and reaction is easily calculated. A diffusion coefficient can then be extracted by data fitting. If reactive decay is due to impurities constituting a fixed percentage of the buffer gas, then two-body reaction rates will scale linearly with pressure and three-body reaction rates will scale quadratically. Also, the diffusion coefficient will scale inversely with pressure. At low pressures it is conceivable that decay due to diffusion would be sufficiently rapid that all other processes can be neglected. Extraction of a diffusion coefficient would then be quite direct. Finally, study of the reaction of cesium and oxygen was undertaken

  7. Working parents: what factors are involved in their ability to take time off from work when their children are sick?

    Science.gov (United States)

    Heymann, S J; Toomey, S; Furstenberg, F

    1999-08-01

    A series of studies has demonstrated that sick children fare better when their parents are present. To examine working conditions that determine whether parents can spend time with and become involved in the care of their children when they are sick. Survey with a multivariate analysis of factors influencing parental care of sick children. Mixed-income urban working parents aged 26 to 29 years participating in the Baltimore Parenthood Study. Only 42% of working parents in our sample cared for their young children when they became sick. A multivariate logistic regression analysis was conducted to predict which parents stayed at home when their children were sick. Those parents who had either paid sick or vacation leave were 5.2 times as likely to care for their children themselves when they were sick. Of parents with less than a high school education, 17% received paid leave, compared with 57% of parents with a general equivalency diploma, 76% of parents with a high school diploma, and 92% of parents with more than a high school education (Pparents were unable to care for their sick children themselves is important for pediatric care. While low-income children are more likely to face marked health problems and to be in need of parental care, they are more likely to live in households in which parents lack paid leave and cannot afford to take unpaid leave.

  8. On solving wave equations on fixed bounded intervals involving Robin boundary conditions with time-dependent coefficients

    Science.gov (United States)

    van Horssen, Wim T.; Wang, Yandong; Cao, Guohua

    2018-06-01

    In this paper, it is shown how characteristic coordinates, or equivalently how the well-known formula of d'Alembert, can be used to solve initial-boundary value problems for wave equations on fixed, bounded intervals involving Robin type of boundary conditions with time-dependent coefficients. A Robin boundary condition is a condition that specifies a linear combination of the dependent variable and its first order space-derivative on a boundary of the interval. Analytical methods, such as the method of separation of variables (SOV) or the Laplace transform method, are not applicable to those types of problems. The obtained analytical results by applying the proposed method, are in complete agreement with those obtained by using the numerical, finite difference method. For problems with time-independent coefficients in the Robin boundary condition(s), the results of the proposed method also completely agree with those as for instance obtained by the method of separation of variables, or by the finite difference method.

  9. System-theoretic analysis of due-time performance in production systems

    Directory of Open Access Journals (Sweden)

    David Jacobs

    1995-01-01

    Full Text Available Along with the average production rate, the due-time performance is an important characteristic of manufacturing systems. Unlike the production rate, the due-time performance has received relatively little attention in the literature, especially in the context of large volume production. This paper is devoted to this topic. Specifically, the notion of due-time performance is formalized as the probability that the number of parts produced during the shipping period reaches the required shipment size. This performance index is analyzed for both lean and mass manufacturing environments. In particular, it is shown that, to achieve a high due-time performance in a lean environment, the production system should be scheduled for a sufficiently small fraction of its average production rate. In mass production, due-time performance arbitrarily close to one can be achieved for any scheduling practice, up to the average production rate.

  10. Shift level analysis of cable yarder availability, utilization, and productive time

    Science.gov (United States)

    James R. Sherar; Chris B. LeDoux

    1989-01-01

    Decision makers, loggers, managers, and planners need to understand and have methods for estimating utilization and productive time of cable logging systems. In making an accurate prediction of how much area and volume a machine will log per unit time and the associated cable yarding costs, a reliable estimate of the availability, utilization, and productive time of...

  11. Pro-inflammatory stimulation of meniscus cells increases production of matrix metalloproteinases and additional catabolic factors involved in osteoarthritis pathogenesis

    Science.gov (United States)

    Stone, Austin V.; Loeser, Richard F.; Vanderman, Kadie S.; Long, David L.; Clark, Stephanie C.; Ferguson, Cristin M.

    2014-01-01

    Objective Meniscus injury increases the risk of osteoarthritis; however, the biologic mechanism remains unknown. We hypothesized that pro-inflammatory stimulation of meniscus would increase production of matrix-degrading enzymes, cytokines and chemokines which cause joint tissue destruction and could contribute to osteoarthritis development. Design Meniscus and cartilage tissue from healthy tissue donors and total knee arthroplasties was cultured. Primary cell cultures were stimulated with pro-inflammatory factors [IL-1β, IL-6, or fibronectin fragments (FnF)] and cellular responses were analyzed by real-time PCR, protein arrays and immunoblots. To determine if NF-κB was required for MMP production, meniscus cultures were treated with inflammatory factors with and without the NF-κB inhibitor, hypoestoxide. Results Normal and osteoarthritic meniscus cells increased their MMP secretion in response to stimulation, but specific patterns emerged that were unique to each stimulus with the greatest number of MMPs expressed in response to FnF. Meniscus collagen and connective tissue growth factor gene expression was reduced. Expression of cytokines (IL-1α, IL-1β, IL-6), chemokines (IL-8, CXCL1, CXCL2, CSF1) and components of the NF-κB and tumor necrosis factor (TNF) family were significantly increased. Cytokine and chemokine protein production was also increased by stimulation. When primary cell cultures were treated with hypoestoxide in conjunction with pro-inflammatory stimulation, p65 activation was reduced as were MMP-1 and MMP-3 production. Conclusions Pro-inflammatory stimulation of meniscus cells increased matrix metalloproteinase production and catabolic gene expression. The meniscus could have an active biologic role in osteoarthritis development following joint injury through increased production of cytokines, chemokines, and matrix-degrading enzymes. PMID:24315792

  12. Biochemical and molecular characterization of Coriolopsis rigida laccases involved in transformation of the solid waste from olive oil production.

    Science.gov (United States)

    Díaz, Rosario; Saparrat, Mario C N; Jurado, Miguel; García-Romera, Inmaculada; Ocampo, Juan Antonio; Martínez, María Jesús

    2010-09-01

    Two laccase isoenzymes were purified and characterized from the basidiomycete Coriolopsis rigida during transformation of the water-soluble fraction of "alpeorujo" (WSFA), a solid residue derived from the olive oil production containing high levels of toxic compounds. Zymogram assays of laccases secreted by the fungus growing on WSFA and WSFA supplemented with glucose showed two bands with isoelectric points of 3.3 and 3.4. The kinetic studies of the two purified isoenzymes showed similar affinity on 2,6-dimethoxyphenol and 2,2'-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid), used as phenolic and non-phenolic model substrate, respectively. The molecular mass of both proteins was 66 kDa with 9% N-linked carbohydrate. Physico-chemical properties of the purified laccases from media containing WSFA were similar to those obtained from medium with glucose as the main carbon source. In-vitro studies performed with the purified laccases revealed a 42% phenol reduction of WSFA, as well as changes in the molecular mass distribution. These findings indicate that these laccases are involved in the process of transformation, via polymerization by the oxidation of phenolic compounds present in WSFA. A single laccase gene, containing an open reading frame of 1,488 bp, was obtained in PCR amplifications performed with cDNA extracted from mycelia grown on WSFA. The product of the gene shares 90% identity (95% similarity) with a laccase from Trametes trogii and 89% identity (95% similarity) with a laccase from Coriolopsis gallica. This is the first report on purification and molecular characterization of laccases directly involved in the transformation of olive oil residues.

  13. Holdup time measurement by radioactive tracers in pulp production

    International Nuclear Information System (INIS)

    Roetzer, H.; Donhoffer, D.

    1988-12-01

    A batch of pulp was to be labelled before passing two bleaching towers of a pulp plant. Activated glass fibres were used as a tracer, which contained 24-Na with a half-life of 15 hours. It was shown in laboratory tests, that the glass fibres were suitable for transport studies of wood pulp. For use in the tests the fibres were activated and suspended in water. Due to the small diameter of the fibres (2-5 micrometers) this suspension shows physical properties very similar to the pulp. For detection six scintillation probes were mounted at different positions outside the bleaching tower. Radiation protection during the test was very easy due to the low total activity of the tracer material. Residence time distributions for both towers were measured. The successful tracer experiments show, that the method of labelling is suited for investigations of material transport in the pulp and paper industry. 3 figs., 11 refs., 2 tabs. (Author)

  14. Feasibility of an energy conversion system in Canada involving large-scale integrated hydrogen production using solid fuels

    International Nuclear Information System (INIS)

    Gnanapragasam, Nirmal V.; Reddy, Bale V.; Rosen, Marc A.

    2010-01-01

    A large-scale hydrogen production system is proposed using solid fuels and designed to increase the sustainability of alternative energy forms in Canada, and the technical and economic aspects of the system within the Canadian energy market are examined. The work investigates the feasibility and constraints in implementing such a system within the energy infrastructure of Canada. The proposed multi-conversion and single-function system produces hydrogen in large quantities using energy from solid fuels such as coal, tar sands, biomass, municipal solid waste (MSW) and agricultural/forest/industrial residue. The proposed system involves significant technology integration, with various energy conversion processes (such as gasification, chemical looping combustion, anaerobic digestion, combustion power cycles-electrolysis and solar-thermal converters) interconnected to increase the utilization of solid fuels as much as feasible within cost, environmental and other constraints. The analysis involves quantitative and qualitative assessments based on (i) energy resources availability and demand for hydrogen, (ii) commercial viability of primary energy conversion technologies, (iii) academia, industry and government participation, (iv) sustainability and (v) economics. An illustrative example provides an initial road map for implementing such a system. (author)

  15. Identification of lipases involved in PBAN stimulated pheromone production in Bombyx mori using the DGE and RNAi approaches.

    Directory of Open Access Journals (Sweden)

    Mengfang Du

    Full Text Available BACKGROUND: Pheromone biosynthesis activating neuropeptide (PBAN is a neurohormone that regulates sex pheromone synthesis in female moths. Bombyx mori is a model organism that has been used to explore the signal transduction pattern of PBAN, which is mediated by a G-protein coupled receptor (GPCR. Although significant progress has been made in elucidating PBAN-regulated lipolysis that releases the precursor of the sex pheromone, little is known about the molecular components involved in this step. To better elucidate the molecular mechanisms of PBAN-stimulated lipolysis of cytoplasmic lipid droplets (LDs, the associated lipase genes involved in PBAN- regulated sex pheromone biosynthesis were identified using digital gene expression (DGE and subsequent RNA interference (RNAi. RESULTS: Three DGE libraries were constructed from pheromone glands (PGs at different developed stages, namely, 72 hours before eclosion (-72 h, new emergence (0 h and 72 h after eclosion (72 h, to investigate the gene expression profiles during PG development. The DGE evaluated over 5.6 million clean tags in each PG sample and revealed numerous genes that were differentially expressed at these stages. Most importantly, seven lipases were found to be richly expressed during the key stage of sex pheromone synthesis and release (new emergence. RNAi-mediated knockdown confirmed for the first time that four of these seven lipases play important roles in sex pheromone synthesis. CONCLUSION: This study has identified four lipases directly involved in PBAN-stimulated sex pheromone biosynthesis, which improve our understanding of the lipases involved in releasing bombykol precursors from triacylglycerols (TAGs within the cytoplasmic LDs.

  16. A Review of Just-In-Time Scheduling for Production and Logistics

    OpenAIRE

    田村, 隆善

    1999-01-01

    The Just-In-Time (JIT) production has been developed as a subsystem of the "whole" Toyota production system (TPS). Currently JIT or JIT production means the TPS especially in foreign countries. It is recognized that JIT is a key concept for enterprises competing in the diversified-products market. The technologies used in JIT are comprehensive and include technologies to design, install and control a production system, which are classified into three categories : hardware, information and sof...

  17. OPTIMIZATION OF TIMES AND COSTS OF PROJECT OF HORIZONTAL LAMINATOR PRODUCTION USING PERT/CPM TECHNICAL

    Directory of Open Access Journals (Sweden)

    Fernando Henrique Lermen

    2016-09-01

    Full Text Available The PERT/CPM is a technique widely used in both the scheduling and in the project feasibility in terms of cost control and time.  In order to optimize time and costs involved in production, the work presented here aims to apply the PERT/CPM technique in the production project of the Horizontal Laminator, a machine used to cut polyurethane foam blocks in the mattresses industries. For the application of PERT/CPM technique in the project of Horizontal Laminator production were identified the activities that compose the project, the dependence between them, the normal and accelerated durations and the normal and accelerated costs. In this study, deterministic estimates for the duration of the activities were considered. The results show that the project can be completed in 520 hours at a total cost of R$7,042.50, when all activities are performed in their normal durations.  When all the activities that compose the critical path are accelerated, the project can be completed in 333.3 hours at a total cost of R$9,263.01. If the activities slacks have been exploited, it can obtain a final total cost of R$6,157.8, without changing the new duration of the project. It is noteworthy that the final total cost of the project if the slacks are used, will be lower than the initial cost. Regarding the initial cost of the project, after the application of the PERT/CPM technique, it presents a decrease of 12.56% of the total project cost.

  18. System-theoretic analysis of due-time performance in production systems

    OpenAIRE

    Jacobs David; Meerkov Semyon M.

    1995-01-01

    Along with the average production rate, the due-time performance is an important characteristic of manufacturing systems. Unlike the production rate, the due-time performance has received relatively little attention in the literature, especially in the context of large volume production. This paper is devoted to this topic. Specifically, the notion of due-time performance is formalized as the probability that the number of parts produced during the shipping period reaches the required shipme...

  19. Effects of Variable Production Rate and Time-Dependent Holding Cost for Complementary Products in Supply Chain Model

    Directory of Open Access Journals (Sweden)

    Mitali Sarkar

    2017-01-01

    Full Text Available Recently, a major trend is going to redesign a production system by controlling or making variable the production rate within some fixed interval to maintain the optimal level. This strategy is more effective when the holding cost is time-dependent as it is interrelated with holding duration of products and rate of production. An effort is made to make a supply chain model (SCM to show the joint effect of variable production rate and time-varying holding cost for specific type of complementary products, where those products are made by two different manufacturers and a common retailer makes them bundle and sells bundles to end customers. Demand of each product is specified by stochastic reservation prices with a known potential market size. Those players of the SCM are considered with unequal power. Stackelberg game approach is employed to obtain global optimum solution of the model. An illustrative numerical example, graphical representation, and managerial insights are given to illustrate the model. Results prove that variable production rate and time-dependent holding cost save more than existing literature.

  20. Lactic acid bacteria involved in cocoa beans fermentation from Ivory Coast: Species diversity and citrate lyase production.

    Science.gov (United States)

    Ouattara, Hadja D; Ouattara, Honoré G; Droux, Michel; Reverchon, Sylvie; Nasser, William; Niamke, Sébastien L

    2017-09-01

    Microbial fermentation is an indispensable process for high quality chocolate from cocoa bean raw material. lactic acid bacteria (LAB) are among the major microorganisms responsible for cocoa fermentation but their exact role remains to be elucidated. In this study, we analyzed the diversity of LAB in six cocoa producing regions of Ivory Coast. Ribosomal 16S gene sequence analysis showed that Lactobacillus plantarum and Leuconostoc mesenteroides are the dominant LAB species in these six regions. In addition, other species were identified as the minor microbial population, namely Lactobacillus curieae, Enterococcus faecium, Fructobacillus pseudoficulneus, Lactobacillus casei, Weissella paramesenteroides and Weissella cibaria. However, in each region, the LAB microbial population was composed of a restricted number of species (maximum 5 species), which varied between the different regions. LAB implication in the breakdown of citric acid was investigated as a fundamental property for a successful cocoa fermentation process. High citrate lyase producer strains were characterized by rapid citric acid consumption, as revealed by a 4-fold decrease in citric acid concentration in the growth medium within 12h, concomitant with an increase in acetic acid and lactic acid concentration. The production of citrate lyase was strongly dependent on environmental conditions, with optimum production at acidic pH (pHfermentation. This study reveals that one of the major roles of LAB in the cocoa fermentation process involves the breakdown of citric acid during the early stage of cocoa fermentation through the activity of citrate lyase. Copyright © 2017 Elsevier B.V. All rights reserved.

  1. Involvement of Acetobacter orientalis in the production of lactobionic acid in Caucasian yogurt ("Caspian Sea yogurt") in Japan.

    Science.gov (United States)

    Kiryu, T; Kiso, T; Nakano, H; Ooe, K; Kimura, T; Murakami, H

    2009-01-01

    Lactobionic acid was first found in a Caucasian fermented milk product popularly known as "Caspian Sea yogurt" in Japan. The presence of lactobionic acid in the fermented milk was indicated by the results of both high-performance anion-exchange chromatographic analysis with pulsed amperometric detection and mass spectrometric analysis. Thereafter, the acid was purified from the yogurt and analyzed by nuclear magnetic resonance. A substantial amount of lactobionic acid was found to be accumulated in the upper layer of the yogurt, especially within 10 mm from the surface. A total of 45 mg of lactobionic acid per 100 g of the upper yogurt layer was collected after 4 d of fermentation. The annual intake of lactobionic acid in individuals consuming 100 g of the yogurt every day would be 0.5 to 1.0 g. A lactose-oxidizing bacterium was isolated from the fermented milk and was identified as Acetobacter orientalis. Washed A. orientalis cells oxidized monosaccharides such as d-glucose at considerable rates, although their activities for substrates such as lactose, maltose, and cellobiose were much lower. When A. orientalis cells were cultivated in cow's milk, they exhibited lactose-oxidizing activity, suggesting that this bacterium was the main organism involved in the production of lactobionic acid in the yogurt.

  2. Biotin in microbes, the genes involved in its biosynthesis, its biochemical role and perspectives for biotechnological production.

    Science.gov (United States)

    Streit, W R; Entcheva, P

    2003-03-01

    Biotin (vitamin H) is one of the most fascinating cofactors involved in central pathways in pro- and eukaryotic cell metabolism. Since its original discovery in 1901, research has led to the discovery of the complete biotin biosynthesis pathways in many different microbes and much work has been done on the highly intriguing and complex biochemistry of biotin biosynthesis. While humans and animals require several hundred micrograms of biotin per day, most microbes, plants and fungi appear to be able to synthesize the cofactor themselves. Biotin is added to many food, feed and cosmetic products, creating a world market of 10-30 t/year. However, the majority of the biotin sold is synthesized in a chemical process. Since the chemical synthesis is linked with a high environmental burden, much effort has been put into the development of biotin-overproducing microbes. A summary of biotin biosynthesis and its biological role is presented; and current strategies for the improvement of microbial biotin production using modern biotechnological techniques are discussed.

  3. Assessment of the occupational exposure of the workers involved in the 123I production at the IEN/CNEN-RJ

    International Nuclear Information System (INIS)

    Araujo, Francisco de

    2005-01-01

    123 I is a gamma emitter used for diagnosis in Nuclear Medicine. Since 1998 it is produced in the Institute of Nuclear Energy (IEN) and supplied to the Clinics and Hospitals located in the city of Rio de Janeiro. The annual production is in the approximately of 0,74 TBq (20 Ci), which represents a risk of external and internal exposure to the workers involved in this activity. A survey of external doses in the period of 1994 to 2004 was carried out based on the individual registries available in the CONEXO Data Base operated by the Institute of Radiation Protection and Dosimetry (IRD). It was verified an increase of the external exposure associated to the production curve. However, the individual doses are all bellow the annual limits established by the regulatory board. On the other hand, the variation of doses among individuals involved in the same tasks suggests the possibility of optimization of procedures. Regarding internal exposure it was calculated a decision factor above 1mSv for the practice, which justifies the need for internal monitoring. An evaluation of the process based on the results of in vivo thyroid monitoring in the period of 2000 to 2004 was carried out to identify the steps which represent higher risk of internal exposure. The available data indicate that the laboratory of quality control is the critical step in terms of internal contamination. This conclusion can be justified by the high volatility of iodine which is manipulated in the form of a liquid open source during this step. With the aim of optimizing monitoring procedures for the control of occupationally exposed workers in the production of 123 I, in vivo and in vitro bioassay methods were developed to identify and quantify internal contamination by such radionuclide, using the detection systems available at the Bioassay Laboratory and at the In Vivo Measurements Laboratory. The techniques developed present sensitivity compatible with the derived registry level associated to the

  4. ASPECTS REGARDING THE SETTING OF TIME STANDARDS FOR THE PRODUCTION AND SEWING OPERATIONS

    Directory of Open Access Journals (Sweden)

    SECAN Cristina

    2014-05-01

    Full Text Available This paper presents the technological process of manufacture of a shoe for women in IL system in order to establish the time and the production norm in the processing-sewing procedure. The sequence of operations is presented in a case study that analyzed how can be obtained the upper assembly of a footwear product that later becomes integral part into the finished product. Drawing up the technological process is done considering both the manual operations and the manual-mechanical operations for processing and assembling the parts that make the whole upper assembly by gluing the parts, by seaming and securing the joints. The type of equipment chosen to carry out operations is influencing through its productivity the necessary material calculated and hence the labour force required. The amount of time consists of time needed for preparation-finishing time, operative time, time of working place service and time of regulated interruptions. These periods of times were determined basically by timing assistance of the manufacturing process throughout its development. Production norm is calculated on the basis of the standard time, taking into account that it represents the amount of products manufactured in a work shift In order to improve the process by reducing the time of production and the number of workers engaged we are considering the automation of the manufacturing process by using modern methods using laser cutting or cutting under running water, automatic sewing machines, strip conveyor belts with pace imposed etc.

  5. The YJR127C/ZMS1 gene product is involved in glycerol-based respiratory growth of the yeast Saccharomyces cerevisiae.

    Science.gov (United States)

    Lu, Lin; Roberts, George G; Oszust, Cynthia; Hudson, Alan P

    2005-10-01

    A putative yeast mitochondrial upstream activating sequence (UAS) was used in a one-hybrid screening procedure that identified the YJR127C ORF on chromosome X. This gene was previously designated ZMS1 and is listed as a transcription factor on the SGD website. Real time RT-PCR assays showed that expression of YJR127C/ZMS1 was glucose-repressible, and a deletion mutant for the gene showed a growth defect on glycerol-based but not on glucose- or ethanol-based medium. Real time RT-PCR analyses identified severely attenuated transcript levels from GUT1 and GUT2 to be the source of that growth defect, the products of GUT1 and GUT2 are required for glycerol utilization. mRNA levels from a large group of mitochondria- and respiration-related nuclear genes also were shown to be attenuated in the deletion mutant. Importantly, transcript levels from the mitochondrial OLI1 gene, which has an associated organellar UAS, were attenuated in the DeltaYJR127C mutant during glycerol-based growth, but those from COX3 (OXI2), which lacks an associated mitochondrial UAS, were not. Transcriptome analysis of the glycerol-grown deletion mutant showed that genes in several metabolic and other categories are affected by loss of this gene product, including protein transport, signal transduction, and others. Thus, the product of YJR127C/ZMS1 is involved in transcriptional control for genes in both cellular genetic compartments, many of which specify products required for glycerol-based growth, respiration, and other functions.

  6. Dlf1, a WRKY transcription factor, is involved in the control of flowering time and plant height in rice.

    Directory of Open Access Journals (Sweden)

    Yuhui Cai

    Full Text Available Flowering time and plant height are important agronomic traits for crop production. In this study, we characterized a semi-dwarf and late flowering (dlf1 mutation of rice that has pleiotropic effects on these traits. The dlf1 mutation was caused by a T-DNA insertion and the cloned Dlf1 gene was found to encode a WRKY transcription factor (OsWRKY11. The dlf1 mutant contains a T-DNA insertion at the promoter region, leading to enhanced accumulation of Dlf1 transcripts, resulting in a semidominant mutation. The dlf1 mutation suppressed the transcription of Ehd2/RID1/OsId1 and its downstream flowering-time genes including Hd1, Ehd1 and Hd3a under both long-day (LD and short-day (SD conditions. Knock-down of Dlf1 expression exhibited early flowering at LD condition related to the wild-type plants. Accumulation of Dlf1 mRNA was observed in most tissues, and two splicing forms of Dlf1 cDNAs were obtained (OsWRKY11.1 and OsWRKY11.2. These two proteins showed transactivation activity in yeast cells. Dlf1 protein was found to be localized in the nucleus. Enhanced expression of OsWRKY11.2 or its 5' truncated gene showed similar phenotypes to the dlf1 mutant, suggesting that it might function as a negative regulator. We conclude that Dlf1 acts as a transactivator to downregulate Ehd2/RID1/OsId1 in the signal transduction pathway of flowering and plays an important role in the regulation of plant height in rice.

  7. Study of obligations defined in agreements between parties involved in clinical trials of medicinal products in Bulgaria.

    Science.gov (United States)

    N Getov, Ilko; Gocheva-Hristova, Tanya; Lebanova, Hristina V; Grigorov, Evgeni E

    2012-08-01

    To analyse and assess the legislative and contractual obligations of the parties involved in the conduct of clinical trials, with identification of the needs for comprehensive contractual regulation of their rights and responsibilities. This survey has been carried out by means of review, analysis of comprehensiveness, comparative legislative analysis and assessment of compliance with the legislation of sample of investigator and site agreements governing the process of conducting clinical trials. The survey comprises analyses of contractual relations between the sponsor of the study and the investigator, and between the sponsor of the study and the trial site, respectively, relevant to clinical trials which are actually conducted in Bulgaria at the time of and following the survey. Comparative method based on pre-defined structured indices was employed to outline the major variances in the volume of responsibilities and obligations of the said parties to the clinical trial, as regulated by the investigator and site agreements. The analysis of comprehensiveness showed evident omissions in the regulation of relations and interactions between the parties to the agreements. The detailed contractual regulation providing for the statutory obligations and responsibilities of the parties involved in the conduct of clinical trials is a good guarantee for proper understanding of the obligations of each party and for compliance with their relevant responsibilities in view of protecting the rights of the participants in the clinical trials - patients or healthy volunteers.

  8. Tricyclic Antidepressant Amitriptyline-induced Glial Cell Line-derived Neurotrophic Factor Production Involves Pertussis Toxin-sensitive Gαi/o Activation in Astroglial Cells.

    Science.gov (United States)

    Hisaoka-Nakashima, Kazue; Miyano, Kanako; Matsumoto, Chie; Kajitani, Naoto; Abe, Hiromi; Okada-Tsuchioka, Mami; Yokoyama, Akinobu; Uezono, Yasuhito; Morioka, Norimitsu; Nakata, Yoshihiro; Takebayashi, Minoru

    2015-05-29

    Further elaborating the mechanism of antidepressants, beyond modulation of monoaminergic neurotransmission, this study sought to elucidate the mechanism of amitriptyline-induced production of glial cell line-derived neurotrophic factor (GDNF) in astroglial cells. Previous studies demonstrated that an amitriptyline-evoked matrix metalloproteinase (MMP)/FGF receptor (FGFR)/FGFR substrate 2α (FRS2α)/ERK cascade is crucial for GDNF production, but how amitriptyline triggers this cascade remains unknown. MMP is activated by intracellular mediators such as G proteins, and this study sought to clarify the involvement of G protein signaling in amitriptyline-evoked GDNF production in rat C6 astroglial cells (C6 cells), primary cultured rat astrocytes, and normal human astrocytes. Amitriptyline-evoked GDNF mRNA expression and release were inhibited by pertussis toxin (PTX), a Gα(i/o) inhibitor, but not by NF449, a Gα(s) inhibitor, or YM-254890, a Gαq inhibitor. The activation of the GDNF production cascade (FGFR/FRS2α/ERK) was also inhibited by PTX. Deletion of Gα(ο1) and Gα(i3) by RNAi demonstrated that these G proteins play important roles in amitriptyline signaling. G protein activation was directly analyzed by electrical impedance-based biosensors (CellKey(TM) assay), using a label-free (without use of fluorescent proteins/probes or radioisotopes) and real time approach. Amitriptyline increased impedance, indicating Gα(i/o) activation that was suppressed by PTX treatment. The impedance evoked by amitriptyline was not affected by inhibitors of the GDNF production cascade. Furthermore, FGF2 treatment did not elicit any effect on impedance, indicating that amitriptyline targets PTX-sensitive Gα(i/o) upstream of the MMP/FGFR/FRS2α/ERK cascade. These results suggest novel targeting for the development of antidepressants. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  9. The changing nicotine products landscape: time to outlaw sales of combustible tobacco products?

    Science.gov (United States)

    Hefler, Marita

    2018-01-01

    Combustible tobacco products are unique both for the extraordinary harm they cause, and the fact that more than 50 years after these harms became known, they continue to be widely and legally available globally. However, the rapid evolution of the nicotine product marketplace in recent years warrants a re-assessment of the viability of phasing out commercial sales of combustible tobacco, and presents an opportunity to end the exceptionalism of combustible tobacco being permitted for sale. © Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.

  10. "Everybody Gotta Have a Dream": Rap-centered Aspirations among Young Black Males Involved in Rap Music Production - A Qualitative Study.

    Science.gov (United States)

    Foster, B Brian

    Youth express diverse desires for their educational and occupational futures. Sometimes these aspirations are directed towards somewhat unconventional careers such as rapping and other types of involvement in rap music production. Although many studies have examined traditional educational and occupational aspirations, less is known about the factors that give rise to rap-centered aspirations and how individuals pursue them, particularly as they transition to early adulthood. Drawing on 54 semi- and unstructured interviews with 29 black young men involved in rap music production, I find that rap-centered aspirations are shaped by a range of factors, most notably feedback regarding one's rap skills, access to recording and production equipment, and the financial means to maintain involvement in rap music production while also ensuring personal and family economic stability. The young men in the study attached different meanings to their aspirations and sometimes recast their motivations for participating in rap music production in response to various social and economic factors.

  11. OMPS Near Real-time Products Available Through NASA LANCE (Land Atmosphere Near Real-time Capability for EOS)

    Science.gov (United States)

    Warnock, A.; Durbin, P. B.; Cechini, M. F.; Masuoka, E.

    2017-12-01

    Near real-time (NRT) images from the NASA Ozone Mapping and Profiler Suite (OMPS) for sulfur dioxide, total column ozone and aerosol index products are now available through NASA's online Land Atmosphere Near real-time Capability for EOS (LANCE) system. Color palettes, image dimensions and data ranges have been aligned with the corresponding OMI products, allowing for direct comparison of OMPS NRT images with OMI NRT images already available in NASA Worldview. The images are delivered to LANCE within hours of satellite observation. LANCE NRT imagery can be interactively viewed through Worldview and the Global Imagery Browse Services (GIBS).

  12. Influence of production time on quality and height of yield of crisp lettuce

    International Nuclear Information System (INIS)

    Odziemkowski, S.; Gajc-Wolska, J.; Skapski, H.

    1998-01-01

    The cultivar of crisp lettuce Saladin, was grown in the field in 10 production terms starting from spring to autumn in 1993-95. The highest average weight of head of crisp lettuce was obtained in earlier terms of production. The head weight at the time of harvest depended on the amount of solar radiation during the time of lettuce head formation

  13. Accelerated stress testing in a time-driven product development process

    NARCIS (Netherlands)

    Lu, Y.; Loh, H.T.; Brombacher, A.C.; Ouden, den P.H.

    2000-01-01

    In order to compete in the market, companies have to produce the right products with a shorter time to market and at lower costs than before. Shorter time to market requires the product development process (PDP) to change the way of working from the classical ‘wait and react’ to anticipating and

  14. Quality Improvement, Inventory Management, Lead Time Reduction and Production Scheduling in High-Mix Manufacturing Environments

    Science.gov (United States)

    2017-01-13

    Quality Improvement , Inventory Management, Lead Time Reduction and Production Scheduling in High-mix Manufacturing Environments by Sean Daigle B.S...Mechanical Engineering Chairman, Department Committee on Graduate Theses 2 Quality Improvement , Inventory Management, Lead Time Reduction and... Production Scheduling in High-mix Manufacturing Environments by Sean Daigle Submitted to the Department of Mechanical Engineering on January 13, 2017, in

  15. Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation.

    Science.gov (United States)

    Liu, Shing Hwa; Sheu, Wayne Huey Herng; Lee, Maw Rong; Lee, Wen Jane; Yi, Yu Chiao; Yang, Tzung Jie; Jen, Jen Fon; Pan, Hung Chuan; Shen, Chin Chang; Chen, Wen Bao; Tien, Hsing Ru; Sheu, Meei Ling

    2013-06-01

    N(ε)-carboxymethyllysine (CML), a major advanced glycation end product, plays a crucial role in diabetes-induced vascular injury. The roles of protein tyrosine phosphatases and vascular endothelial growth factor (VEGF) receptors in CML-related endothelial cell injury are still unclear. Human umbilical vein endothelial cells (HUVECs) are a commonly used human EC type. Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury. CML significantly inhibited cell proliferation and induced apoptosis and reduced VEGFR-2 activation in parallel with the increased SHP-1 protein expression and activity in HUVECs. Adding recombinant VEGF increased forward biological effects, which were attenuated by CML. The effects of CML on HUVECs were abolished by SHP-1 siRNA transfection. Exposure of HUVECs to CML also remarkably escalated the integration of SHP-1 with VEGFR-2. Consistently, SHP-1 siRNA transfection and pharmacological inhibitors could block this interaction and elevating [(3)H]thymidine incorporation. CML also markedly activated the NADPH oxidase and ROS production. The CML-increased SHP-1 activity in HUVECs was effectively attenuated by antioxidants. Moreover, the immunohistochemical staining of SHP-1 and CML was increased, but phospho-VEGFR-2 staining was decreased in the aortic endothelium of streptozotocin-induced and high-fat diet-induced diabetic mice. We conclude that a pathway of tyrosine phosphatase SHP-1-regulated VEGFR-2 dephosphorylation through NADPH oxidase-derived ROS is involved in the CML-triggered endothelial cell dysfunction/injury. These findings suggest new insights into the development of therapeutic approaches to reduce diabetic vascular complications. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  16. Genome Wide Re-Annotation of Caldicellulosiruptor saccharolyticus with New Insights into Genes Involved in Biomass Degradation and Hydrogen Production.

    Science.gov (United States)

    Chowdhary, Nupoor; Selvaraj, Ashok; KrishnaKumaar, Lakshmi; Kumar, Gopal Ramesh

    2015-01-01

    _0437 and Csac_0424 encode for glycoside hydrolases (GH) and are proposed to be involved in the decomposition of recalcitrant plant polysaccharides. Similarly, HPs: Csac_0732, Csac_1862, Csac_1294 and Csac_0668 are suggested to play a significant role in biohydrogen production. Function prediction of these HPs by using our integrated approach will considerably enhance the interpretation of large-scale experiments targeting this industrially important organism.

  17. Genome Wide Re-Annotation of Caldicellulosiruptor saccharolyticus with New Insights into Genes Involved in Biomass Degradation and Hydrogen Production.

    Directory of Open Access Journals (Sweden)

    Nupoor Chowdhary

    suggest that Csac_0437 and Csac_0424 encode for glycoside hydrolases (GH and are proposed to be involved in the decomposition of recalcitrant plant polysaccharides. Similarly, HPs: Csac_0732, Csac_1862, Csac_1294 and Csac_0668 are suggested to play a significant role in biohydrogen production. Function prediction of these HPs by using our integrated approach will considerably enhance the interpretation of large-scale experiments targeting this industrially important organism.

  18. Products cooked in preheated versus non-preheated ovens. Baking times, calculated energy consumption, and product quality compared.

    Science.gov (United States)

    Odland, D; Davis, C

    1982-08-01

    Plain muffins, yellow cake, baked custard, apple pie, tuna casserole, frozen tuna casserole, cheese soufflé, and meat loaf were baked in preheated and non-preheated standard gas, continuous-clean gas, standard electric, and self-cleaning electric ovens. Products generally required 5 min. or less extra baking time when cooked in non-preheated rather than in preheated ovens. The variability in baking times often was less between preheated and non-preheated ovens than among oven types. Calculated energy consumption values showed that usually less energy was required to bake products in non-preheated than in preheated ovens; savings averaged about 10 percent. Few significant differences were found in physical measurements or eating quality either between preheated and non-preheated ovens or among oven types. Overall, for the products tested, findings confirmed that preheating the oven is not essential for good product quality and, therefore, is an unnecessary use of energy.

  19. Transcription elongation factors are involved in programming hormone production in pituitary neuroendocrine GH4C1 cells.

    Science.gov (United States)

    Fujita, Toshitsugu; Piuz, Isabelle; Schlegel, Werner

    2010-05-05

    Transcription elongation of many eukaryotic genes is regulated. Two negative transcription elongation factors, 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB) sensitivity-inducing factor (DSIF) and negative elongation factor (NELF) are known to stall collaboratively RNA polymerase II promoter proximally. We discovered that DSIF and NELF are linked to hormone expression in rat pituitary GH4C1 cells. When NELF-E, a subunit of NELF or Spt5, a subunit of DSIF was stably knocked-down, prolactin (PRL) expression was increased both at the mRNA and protein levels. In contrast, stable knock-down of only Spt5 abolished growth hormone (GH) expression. Transient NELF-E knock-down increased coincidentally PRL expression and enhanced transcription of a PRL-promoter reporter gene. However, no direct interaction of NELF with the PRL gene could be demonstrated by chromatin immuno-precipitation. Thus, NELF suppressed PRL promoter activity indirectly. In conclusion, transcription regulation by NELF and DSIF is continuously involved in the control of hormone production and may contribute to neuroendocrine cell differentiation. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.

  20. LaeA and VeA are involved in growth morphology, asexual development, and mycotoxin production in Alternaria alternata.

    Science.gov (United States)

    Estiarte, N; Lawrence, C B; Sanchis, V; Ramos, A J; Crespo-Sempere, A

    2016-12-05

    Alternaria alternata is a common filamentous fungus that contaminates various fruits, grains and vegetables causing important economic losses to farmers and the food industry. A. alternata is a mycotoxigenic mould, which may jeopardize human and animal health. Two of the most common A. alternata mycotoxins found in food and feed are alternariol and alternariol monomethyl ether. In this study we examined the role of LaeA and VeA, two regulatory proteins belonging to the velvet family, which have been described to be involved in several functions in many fungi including secondary metabolism. We found that deletion of laeA and veA genes, respectively, greatly reduced sporulation and strongly compromised mycotoxin production, both in vitro or during pathogenesis of tomato fruits. We have also studied how the loss of laeA and veA may affect expression of genes related to alternariol and alternariol monomethyl ether biosynthesis (pksJ and altR), and to melanin biosynthesis (cmrA, pksA). Copyright © 2016 Elsevier B.V. All rights reserved.

  1. INNOVATIVE TECHNIQUES USED BY EPA, SCDHEC, AND DOE TO INCREASE STAKEHOLDER AND PUBLIC INVOLVEMENT IN THE CLEANUP OF NUCLEAR PRODUCTION FACILITIES

    International Nuclear Information System (INIS)

    Mccollum, L

    2007-01-01

    This paper will describe the importance of public and stakeholder involvement to the decisions being made at Savannah River Site (SRS) regarding the cleanup of major production facilities. For over a decade the Department of Energy (DOE), the U.S. Environmental Protection Agency (EPA) and the South Carolina Department of Health and Environmental Control (SCDHEC) have operated under a three party agreement (known as the Federal Facilities Agreement or FFA) to clean up the SRS from the remnants of the Cold War plutonium production at SRS. During this time, the 3 agencies have consulted with the surrounding and impacted public to gain stakeholder input on the decisions concerning the clean up of various wastes at the SRS. The primary instrument of public input has been and remains the SRS Community Advisory Board (CAB). Much progress has been made over the years in cleaning up the SRS and the CAB has provided invaluable stakeholder input. Many planned decisions have been modified and changed as a result of the input of the CAB. Recently, DOE has decided to move forward with the Decommissioning of excess facilities at the SRS. These facilities include many buildings involved in the various missions of radioactive isotope production at the SRS, including the reactors and the plutonium processing facilities. The discussions of the 3 agencies on how to best accomplish this work have always included discussions about how to best involve and receive input from all stakeholders. The innovative way the 3 agencies have worked together through the public involvement format has application nationally and DOE-Complex wide. The decisions made will impact the surrounding community and the country for years. Multiple meetings with the CAB and other stakeholders will be required and it will be incumbent on the 3 agencies to reach out to and involve all interested parties. At least 3 different approaches could be used for stakeholder involvement. (1) a typical CERCLA ''proposed plan

  2. The Involved Ostrich

    DEFF Research Database (Denmark)

    Davies, Andrea; Dobscha, Susan; Geiger, Susi

    2008-01-01

    that the transition into parenthood can be difficult for men due to their lack of a physical connection to the pregnancy, a perception that the baby industry is not designed for them, the continuance of male stereotypes in the media, and also the time available to men to become involved in consumption activities......-natal data. Data revealed that men, according to their partner’s perceptions, used consumption as a virtual umbilical cord, although levels of consumption involvement varied from co-involvement for most purchases, to limited involvement, and/or involvement for ‘large’ items, particularly travel systems...... and technical items. This research also revealed that men partook in highly masculinized forms of “nesting,” and in general shunned pregnancy book reading; although some did engage in “research” activities such as searching the internet for product safety information. We conclude from this study...

  3. Real-time product attribute control to manufacture antibodies with defined N-linked glycan levels.

    Science.gov (United States)

    Zupke, Craig; Brady, Lowell J; Slade, Peter G; Clark, Philip; Caspary, R Guy; Livingston, Brittney; Taylor, Lisa; Bigham, Kyle; Morris, Arvia E; Bailey, Robert W

    2015-01-01

    Pressures for cost-effective new therapies and an increased emphasis on emerging markets require technological advancements and a flexible future manufacturing network for the production of biologic medicines. The safety and efficacy of a product is crucial, and consistent product quality is an essential feature of any therapeutic manufacturing process. The active control of product quality in a typical biologic process is challenging because of measurement lags and nonlinearities present in the system. The current study uses nonlinear model predictive control to maintain a critical product quality attribute at a predetermined value during pilot scale manufacturing operations. This approach to product quality control ensures a more consistent product for patients, enables greater manufacturing efficiency, and eliminates the need for extensive process characterization by providing direct measures of critical product quality attributes for real time release of drug product. © 2015 American Institute of Chemical Engineers.

  4. Synthetic addiction extends the productive life time of engineered Escherichia coli populations

    DEFF Research Database (Denmark)

    Rugbjerg, Peter; Sarup-Lytzen, Kira; Nagy, Mariann

    2018-01-01

    range of genetic variants that disrupt the biosynthetic capacity of the engineered organism. Synthetic product addiction that couples high-yield production of a desired metabolite to expression of nonconditionally essential genes could offer a solution to this problem by selectively favoring cells...... with biosynthetic capacity in the population without constraining the medium. We constructed such synthetic product addiction by controlling the expression of two nonconditionally essential genes with a mevalonic acid biosensor. The product-addicted production organism retained high-yield mevalonic acid production...... through 95 generations of cultivation, corresponding to the number of cell generations required for >200-m3 industrial-scale production, at which time the nonaddicted strain completely abolished production. Using deep DNA sequencing, we find that the product-addicted populations do not accumulate genetic...

  5. Effects of oncoming target velocities on rapid force production and accuracy of force production intensity and timing.

    Science.gov (United States)

    Ohta, Yoichi

    2017-12-01

    The present study aimed to clarify the effects of oncoming target velocities on the ability of rapid force production and accuracy and variability of simultaneous control of both force production intensity and timing. Twenty male participants (age: 21.0 ± 1.4 years) performed rapid gripping with a handgrip dynamometer to coincide with the arrival of an oncoming target by using a horizontal electronic trackway. The oncoming target velocities were 4, 8, and 12 m · s -1 , which were randomly produced. The grip force required was 30% of the maximal voluntary contraction. Although the peak force (Pf) and rate of force development (RFD) increased with increasing target velocity, the value of the RFD to Pf ratio was constant across the 3 target velocities. The accuracy of both force production intensity and timing decreased at higher target velocities. Moreover, the intrapersonal variability in temporal parameters was lower in the fast target velocity condition, but constant variability in 3 target velocities was observed in force intensity parameters. These results suggest that oncoming target velocity does not intrinsically affect the ability for rapid force production. However, the oncoming target velocity affects accuracy and variability of force production intensity and timing during rapid force production.

  6. The AMP-activated protein kinase is involved in the regulation of ketone body production by astrocytes.

    Science.gov (United States)

    Blázquez, C; Woods, A; de Ceballos, M L; Carling, D; Guzmán, M

    1999-10-01

    The possible role of the AMP-activated protein kinase (AMPK), a highly conserved stress-activated kinase, in the regulation of ketone body production by astrocytes was studied. AMPK activity in rat cortical astrocytes was three times higher than in rat cortical neurons. AMPK in astrocytes was shown to be functionally active. Thus, incubation of astrocytes with 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR), a cell-permeable activator of AMPK, stimulated both ketogenesis from palmitate and carnitine palmitoyltransferase I. This was concomitant to a decrease of intracellular malonyl-CoA levels and an inhibition of acetyl-CoA carboxylase/fatty acid synthesis and 3-hydroxy-3-methylglutaryl-CoA reductase/cholesterol synthesis. Moreover, in microdialysis experiments AICAR was shown to stimulate brain ketogenesis markedly. The effect of chemical hypoxia on AMPK and the ketogenic pathway was studied subsequently. Incubation of astrocytes with azide led to a remarkable drop of fatty acid beta-oxidation. However, activation of AMPK during hypoxia compensated the depression of beta-oxidation, thereby sustaining ketone body production. This effect seemed to rely on the cascade hypoxia --> increase of the AMP/ATP ratio --> AMPK stimulation --> acetyl-CoA carboxylase inhibition --> decrease of malonyl-CoA concentration --> carnitine palmitoyltransferase I deinhibition --> enhanced ketogenesis. Furthermore, incubation of neurons with azide blunted lactate oxidation, but not 3-hydroxybutyrate oxidation. Results show that (a) AMPK plays an active role in the regulation of ketone body production by astrocytes, and (b) ketone bodies produced by astrocytes during hypoxia might be a substrate for neuronal oxidative metabolism.

  7. Tetraplex PCR assay involving double gene-sites discriminates beef and buffalo in Malaysian meat curry and burger products.

    Science.gov (United States)

    Hossain, M A Motalib; Ali, Md Eaqub; Hamid, Sharifah Bee Abd; Hossain, S M Azad; Asing; Nizar, Nina Naquiah Ahmad; Uddin, Mohammad Nasir; Ali, Lokman; Asaduzzaman, Md; Akanda, Md Jahurul Haque

    2017-06-01

    Replacement of beef by buffalo and vice versa is frequent in global markets, but their authentication is challenging in processed foods due to the fragmentation of most biomarkers including DNA. The shortening of target sequences through use of two target sites might ameliorate assay reliability because it is highly unlikely that both targets will be lost during food processing. For the first time, we report a tetraplex polymerase chain reaction (PCR) assay targeting two different DNA regions in beef (106 and 120-bp) and buffalo (90 and 138-bp) mitochondrial genes to discriminate beef and buffalo in processed foods. All targets were stable under boiling, autoclaving and microwave cooking conditions. A survey in Malaysian markets revealed 71% beef curries contained buffalo but there was no buffalo in beef burgers. The assay detected down to 0.01ng DNA and 1% meat in admixed and burger products. Copyright © 2016 Elsevier Ltd. All rights reserved.

  8. Damage of polyesters by the atmospheric free radical oxidant NO3 •: a product study involving model systems

    Science.gov (United States)

    Goeschen, Catrin

    2013-01-01

    Summary Manufactured polymer materials are used in increasingly demanding applications, but their lifetime is strongly influenced by environmental conditions. In particular, weathering and ageing leads to dramatic changes in the properties of the polymers, which results in decreased service life and limited usage. Despite the heavy reliance of our society on polymers, the mechanism of their degradation upon exposure to environmental oxidants is barely understood. In this work, model systems of important structural motifs in commercial high-performing polyesters were used to study the reaction with the night-time free radical oxidant NO3 • in the absence and presence of other radical and non-radical oxidants. Identification of the products revealed ‘hot spots’ in polyesters that are particularly vulnerable to attack by NO3 • and insight into the mechanism of oxidative damage by this environmentally important radical. It is suggested that both intermediates as well as products of these reactions are potentially capable of promoting further degradation processes in polyesters under environmental conditions. PMID:24204400

  9. Choice of foods: Allocation of time and money, household production and market services

    DEFF Research Database (Denmark)

    Bonke, Jens

    1992-01-01

    of meals as a case of household production with four kinds of input: the food products bought, the time used for shopping, cooking, and washing up, ho capital like kitchen appliances, and human capital like cooking skills. Maximum welfare will result when these inputs are optimised given the household...... somewhat in the same period, the overall disposable time for households has been going down. At the same time, incomes have been rising. Rational economic behaviour would imply that households react to these changed constraints by employing time-saving and time-buying strategies in meal preparation. 4......'s constraints of disposable income and disposable time. 3. In recent decades, women's participation in the labour market has increased significantly, with non-employed women becoming employed part-time, and part-time employed women becoming employed full-time. Even though men's working time has decreased...

  10. Active pharmaceutical ingredient (API) production involving continuous processes--a process system engineering (PSE)-assisted design framework.

    Science.gov (United States)

    Cervera-Padrell, Albert E; Skovby, Tommy; Kiil, Søren; Gani, Rafiqul; Gernaey, Krist V

    2012-10-01

    A systematic framework is proposed for the design of continuous pharmaceutical manufacturing processes. Specifically, the design framework focuses on organic chemistry based, active pharmaceutical ingredient (API) synthetic processes, but could potentially be extended to biocatalytic and fermentation-based products. The method exploits the synergic combination of continuous flow technologies (e.g., microfluidic techniques) and process systems engineering (PSE) methods and tools for faster process design and increased process understanding throughout the whole drug product and process development cycle. The design framework structures the many different and challenging design problems (e.g., solvent selection, reactor design, and design of separation and purification operations), driving the user from the initial drug discovery steps--where process knowledge is very limited--toward the detailed design and analysis. Examples from the literature of PSE methods and tools applied to pharmaceutical process design and novel pharmaceutical production technologies are provided along the text, assisting in the accumulation and interpretation of process knowledge. Different criteria are suggested for the selection of batch and continuous processes so that the whole design results in low capital and operational costs as well as low environmental footprint. The design framework has been applied to the retrofit of an existing batch-wise process used by H. Lundbeck A/S to produce an API: zuclopenthixol. Some of its batch operations were successfully converted into continuous mode, obtaining higher yields that allowed a significant simplification of the whole process. The material and environmental footprint of the process--evaluated through the process mass intensity index, that is, kg of material used per kg of product--was reduced to half of its initial value, with potential for further reduction. The case-study includes reaction steps typically used by the pharmaceutical

  11. Time delays between core power production and external detector response from Monte Carlo calculations

    International Nuclear Information System (INIS)

    Valentine, T.E.; Mihalczo, J.T.

    1996-01-01

    One primary concern for design of safety systems for reactors is the time response of external detectors to changes in the core. This paper describes a way to estimate the time delay between the core power production and the external detector response using Monte Carlo calculations and suggests a technique to measure the time delay. The Monte Carlo code KENO-NR was used to determine the time delay between the core power production and the external detector response for a conceptual design of the Advanced Neutron Source (ANS) reactor. The Monte Carlo estimated time delay was determined to be about 10 ms for this conceptual design of the ANS reactor

  12. Design of Real Time Data Acquisition System Framework for Production Workshop Based on OPC Technology

    Directory of Open Access Journals (Sweden)

    Yue-xin Yang

    2017-01-01

    Full Text Available In this paper, the low level of production management information in a hydraulic torque converter enterprise is presented. It is needed to develop a digital assembly shop MES to solve this problem. There is a high demand for the real-time data acquisition of the production line in the digital assembly shop MES. According to the actual needs of MES in digital assembly workshop, a real time data acquisition system framework based on OPC technology and database technology is proposed. The framework can be used to meet the actual needs of the real time monitoring system and production business information processing in MES.

  13. Balancing development costs and sales to optimize the development time of product line additions

    NARCIS (Netherlands)

    Langerak, F.; Griffin, A.; Hultink, E.J.

    2010-01-01

    Development teams often use mental models to simplify development time decision making because a comprehensive empirical assessment of the trade-offs across the metrics of development time, development costs, proficiency in market-entry timing, and new product sales is simply not feasible.

  14. Faculty Time Allocations and Research Productivity: Gender, Race, and Family Effects.

    Science.gov (United States)

    Bellas, Marcia L.; Toutkoushian, Robert K.

    1999-01-01

    A study using data from 14,614 full-time faculty examined total work hours, research productivity, and allocation of work time among teaching, research, and service. The study found variation in time expenditures and research output influenced by gender, race/ethnicity, and marital/parental status, but findings were also sensitive to definitions…

  15. Modulation of macrophage Ia expression by lipopolysaccharide: Stem cell requirements, accessory lymphocyte involvement, and IA-inducing factor production

    International Nuclear Information System (INIS)

    Wentworth, P.A.; Ziegler, H.K.

    1989-01-01

    The mechanism of induction of murine macrophage Ia expression by lipopolysaccharide (LPS) was studied. Intraperitoneal injection of 1 microgram of LPS resulted in a 3- to 10-fold increase in the number of IA-positive peritoneal macrophages (flow cytometry and immunofluorescence) and a 6-to 16-fold increase by radioimmunoassay. The isolated lipid A moiety of LPS was a potent inducer of macrophage Ia expression. Ia induction required a functional myelopoietic system as indicated by the finding that the response to LPS was eliminated in irradiated (900 rads) mice and reinstated by reconstitution with bone marrow cells. Comparison of LPS-induced Ia expression in normal and LPS-primed mice revealed a faster secondary response to LPS. The memory response could be adoptively transferred to normal mice with nonadherent spleen cells prepared 60 days after LPS injection. Spleen cells prepared 5 days after LPS injection caused Ia induction in LPS-nonresponder mice; such induction was not observed in irradiated (900 rads) recipients. The cell responsible for this phenomenon was identified as a Thy-1+, immunoglobulin-negative nonadherent cell. The biosynthesis and expression of Ia were not increased by direct exposure of macrophages to LPS in vitro. Small amounts of LPS inhibited Ia induction by gamma interferon. LPS showed positive regulatory effects on Ia expression by delaying the loss of Ia expression on cultured macrophages and by stimulating the production of Ia-inducing factors. Supernatants from cultured spleen cells stimulated with LPS in vitro contained antiviral and Ia-inducing activity that was acid labile, indicating that the active factor is gamma interferon. We conclude that induction of Ia expression by LPS in vivo is a bone-marrow-dependent, radiation-sensitive process which involves the stimulation of a gamma interferon-producing accessory lymphocyte and a delay in Ia turnover

  16. Involvement of major components from Sporothrix schenckii cell wall in the caspase-1 activation, nitric oxide and cytokines production during experimental sporotrichosis.

    Science.gov (United States)

    Gonçalves, Amanda Costa; Maia, Danielle Cardoso Geraldo; Ferreira, Lucas Souza; Monnazzi, Luis Gustavo Silva; Alegranci, Pâmela; Placeres, Marisa Campos Polesi; Batista-Duharte, Alexander; Carlos, Iracilda Zeppone

    2015-02-01

    Sporotrichosis is a chronic infection caused by the dimorphic fungus Sporothrix schenckii, involving all layers of skin and the subcutaneous tissue. The role of innate immune toll-like receptors 2 and 4 in the defense against this fungus has been reported, but so far, there were no studies on the effect of cell wall major components over the cytosolic oligo-merization domain (NOD)-like receptors, important regulators of inflammation and responsible for the maturation of IL-1β and IL-18, whose functions are dependents of the caspase-1 activation, that can participate of inflammasome. It was evaluated the percentage of activation of caspase-1, the production of IL-1β, IL-18, IL-17, IFN-γ and nitric oxide in a Balb/c model of S. schenckii infection. It was observed a decreased activity of caspase-1 during the fourth and sixth weeks of infection accompanied by reduced secretion of the cytokines IL-1β, IL-18 and IL-17 and high production of nitric oxide. IFN-γ levels were elevated during the entire time course of infection. This temporal reduction in caspase-1 activity coincides exactly with the reported period of fungal burden associated with a transitory immunosuppression induced by this fungus and detected in similar infection models. These results indicate the importance of interaction between caspase-1, cytokines IL-1β and IL-18 in the host defense against S. schenckii infection, suggesting a participation the inflammasome in this response.

  17. Optimization of nutritional and non-nutritional factors involved for production of antimicrobial compounds from Lactobacillus pentosus SJ65 using response surface methodology

    Directory of Open Access Journals (Sweden)

    Appukuttan Saraniya

    2014-01-01

    Full Text Available Bacteriocins from lactic acid bacteria are ribosomal synthesized antibacterial proteins/ peptides having wide range of applications. Lactobacillus pentosus SJ65, isolated from fermented Uttapam batter (used to prepare south Indian pan cake, produces bacteriocin having a broad spectrum of activity against pathogens. Optimization studies are of utmost important to understand the source of utilization and the conditions to enhance the production of metabolites. In the present study, an attempt was made to identify the parameters involved for maximal production of antimicrobial compounds especially bacteriocin from the isolate L. pentosus SJ65. Initially, optimal conditions, such as incubation period, pH, and temperature were evaluated. Initial screening was done using methodology onevariable-at-a-time (OVAT for various carbon and nitrogen sources. Further evaluation was carried out statistically using Plackett-Burman design and the variables were analyzed using response surface methodology using central composite design. The optimum media using tryptone or soy peptone, yeast extract, glucose, triammonium citrate, MnSO4, dipotassium hydrogen phosphate and tween 80 produced maximum bacteriocin activity.

  18. Intramuscular tendon involvement on MRI has limited value for predicting time to return to play following acute hamstring injury

    NARCIS (Netherlands)

    van der Made, Anne D.; Almusa, Emad; Whiteley, Rod; Hamilton, Bruce; Eirale, Cristiano; van Hellemondt, Frank; Tol, Johannes L.

    2018-01-01

    Background Hamstring injury with intramuscular tendon involvement is regarded as a serious injury with a delay in return to play (RTP) of more than 50 days and reinjury rates up to 63%. However, this reputation is based on retrospective case series with high risk of bias. Objective Determine whether

  19. Fathers' Involvement with Their Preschool-Age Children: How Fathers Spend Time with Their Children in Different Family Structures

    Science.gov (United States)

    Halme, Nina; Astedt-Kurki, Paivi; Tarkka, Marja-Terttu

    2009-01-01

    The purpose of this study was to describe how fathers (n = 263) spent time with their preschool-age children and to compare it in different family structures. Data were gathered by structured questionnaires. The instrument included five categories of variables for the time spent: the quantity of time, physical activities, fathers' attitude towards…

  20. Novel dark fermentation involving bioaugmentation with constructed bacterial consortium for enhanced biohydrogen production from pretreated sewage sludge

    Energy Technology Data Exchange (ETDEWEB)

    Kotay, Shireen Meher; Das, Debabrata [Department of Biotechnology, Indian Institute of Technology, Kharagpur (India)

    2009-09-15

    The present study summarizes the observations on various nutrient and seed formulation methods using sewage sludge that have been aimed at ameliorating the biohydrogen production potential. Pretreatment methods viz., acid/base treatment, heat treatment, sterilization, freezing-thawing, microwave, ultrasonication and chemical supplementation were attempted on sludge. It was observed that pretreatment was essential not only to reduce the needless, competitive microbial load but also to improve the nutrient solublization of sludge. Heat treatment at 121 C for 20 min was found to be most effective in reducing the microbial load by 98% and hydrolyzing the organic fraction of sludge. However, this pretreatment alone was either not sufficient or inconsistent in developing a suitable microbial consortium for hydrogen production. Hydrogen yield was found to improve 1.5-4 times upon inoculation with H{sub 2}-producing microorganisms. A defined microbial consortium was developed consisting of three established bacteria viz., Enterobacter cloacae IIT-BT 08, Citrobacter freundii IIT-BT L139 and Bacillus coagulans IIT-BT S1. Following pretreatments soluble proteins and lipids (the major component of the sludge) were also found to be consumed besides carbohydrates. This laid out the concurrent proteolytic/lipolytic ability of the developed H{sub 2}-producing consortium. 1:1:1 v/v ratio of these bacteria in consortium was found to give the maximum yield of H{sub 2} from sludge, 39.15 ml H{sub 2}/g COD{sub reduced}. 15%v/v dilution and supplementation with 0.5%w/v cane molasses prior to heat treatment was found to further improve the yield to 41.23 ml H{sub 2}/g COD{sub reduced}. (author)

  1. Study of relationship between time overrun and productivity on construction sites

    Directory of Open Access Journals (Sweden)

    Ameh, Oko John

    2011-12-01

    Full Text Available The history of the construction industry worldwide is full of projects that were completed with significant time and cost overruns. In an attempt to reverse this trend, this study aims at establishing the relationship between time overrun and labour productivity on construction sites in Lagos, Nigeria. 43 technical and management staff of some medium and large construction firms based in Lagos, Nigeria were sampled and administered a questionnaire survey. The questionnaire contained 18 causes of project time overrun and 14 causes of low labour productivity which had been identified from the literature reviewed. With these a relationship between project time overrun and low labour productivity was established. Both descriptive and inferential statistics were used in analyzing the data. Results indicate that inadequate funds for the project, inadequate planning before project takeoff, inadequate tools and equipment and delay in delivery of material top the list of major causes of time overrun while the use of wrong construction methods, inadequate construction materials and inaccurate drawing/specification are the key factors causing low labour productivity on construction sites. Significant negative relationship was found between time overrun and labour productivity in construction sites in Nigeria. The study concludes by recommending that early appointment of project managers could ensure proper management of both the human and material resources that could guarantee improved productivity and ultimately save projects from time overrun.

  2. Animal DNA identification in food products and animal feed by real time polymerase chain reaction method

    Directory of Open Access Journals (Sweden)

    Людмила Мар’янівна Іщенко

    2016-11-01

    Full Text Available Approbation of diagnostic tests for species identification of beef, pork and chicken by real time polymerase chain reaction method was done. Meat food, including heat treated and animal feed, was used for research. The fact of inconsistencies was revealed for product composition of some meat products that is marked by manufacturer 

  3. Order Level Inventory Models for Deteriorating Seasonable/Fashionable Products with Time Dependent Demand and Shortages

    OpenAIRE

    Skouri, K.; Konstantaras, I.

    2009-01-01

    An order level inventory model for seasonable/fashionable products subject to a period of increasing demand followed by a period of level demand and then by a period of decreasing demand rate (three branches ramp type demand rate) is considered. The unsatisfied demand is partially backlogged with a time dependent backlogging rate. In addition, the product deteriorates with a time dependent, namely, Weibull, deterioration rate. The model is studied under the following different replenishment p...

  4. Design of Real Time Data Acquisition System Framework for Production Workshop Based on OPC Technology

    OpenAIRE

    Yue-xin Yang; Gong-chang Ren

    2017-01-01

    In this paper, the low level of production management information in a hydraulic torque converter enterprise is presented. It is needed to develop a digital assembly shop MES to solve this problem. There is a high demand for the real-time data acquisition of the production line in the digital assembly shop MES. According to the actual needs of MES in digital assembly workshop, a real time data acquisition system framework based on OPC technology and database technology is proposed. The framew...

  5. The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production

    DEFF Research Database (Denmark)

    Aerts, David; Hauer, Esther E.; Ohm, Robin A.

    2018-01-01

    , including 10 out of 12 genes of the fumonisin cluster. This was accompanied by absence of fumonisin production in the deletion strain and a 25% reduction in production of pyranonigrin A. Together, these results link FlbA-mediated sporulation-inhibited secretion with mycotoxin production....

  6. Influence of the Time Perspective on New Product Development Success Indicators

    DEFF Research Database (Denmark)

    Kazerouni, Afrooz M.; Achiche, Sofiane; Hisarciklilar, Onur

    2011-01-01

    Understanding the underlying reasons for new product development success is central to effective new product management. However, difficulties related to estimating to what extent the objectives are being fulfilled and assessing the trade-offs between different project goals makes the new product...... of this research is to determine the appropriate sets of metrics to be used for assessing success during each phase of a product lifecycle. A practical case study was carried out by investigating 28 companies from Canadian and Danish industries. The companies are various industrial sectors. The data collection...... as they change depending on where a product is in its lifecycle. The influence of this time perspective on success indicators of new product developments has not been explored very extensively. In this paper, we investigate the success criteria during different phases of the product lifecycle. The goal...

  7. Precipitation Analysis at Fine Time Scales Using Multiple Satellites: Real-time and Research Products and Applications

    Science.gov (United States)

    Adler, Robert; Huffman, George; Bolvin, David; Nelkin, Eric; Curtis, Scott; Pierce, Harold

    2004-01-01

    Quasi-global precipitation analyses at fine time scales (3-hr) are described. TRMM observations (radar and passive microwave) are used to calibrate polar-orbit microwave observations from SSM/I (and other satellites instruments, including AMSR and AMSU) and geosynchronous IR observations. The individual data sets are then merged using a priority order based on quality to form the Multi-satellite Precipitation Analysis (MPA). Raingauge information is used to help constrain the satellite-based estimates over land. The TRMM standard research product (Version 6 3B-42 of the TRMM products) will be available for the entire TRMM period (January 1998-present) in 2004. The real-time version of this merged product has been produced over the past two years and is available on the U.S. TRMM web site (trmm.gsfc.nasa.gov) at 0.25" latitude-longitude resolution over the latitude range from 5O"N-5O0S. Validation of daily totals indicates good results, with limitations noted in mid-latitude winter over land and regions of shallow, orographic precipitation. Various applications of these estimates are described, including: 1) detecting potential floods in near real-time; 2) analyzing Indian Ocean precipitation variations related to the initiation of El Nino; 3) determining characteristics of the African monsoon; and 4) analysis of diurnal variations.

  8. Precipitation Analysis at Fine Time Scales using TRMM and Other Satellites: Real-time and Research Products and Applications

    Science.gov (United States)

    Adler, Robert; Huffman, George; Bolvin, David; Nelkin, Eric; Curtis, Scott; Pierce, Harold; Gu, Guo-Jon

    2004-01-01

    Quasi-global precipitation analyses at fine time scales (3-hr) are described. TRMM observations (radar and passive microwave) are used to calibrate polar-orbit microwave observations from SSM/I (and other satellites instruments, including AMSR and AMSU) and geosynchronous IR observations. The individual data sets are then merged using a priority order based on quality to form the TRMM Multi-satellite Precipitation Analysis (MPA). Raingauge information is used to help constrain the satellite-based estimates over land. The TRMM standard research product (Version 6 3B-42 of the TRMM products) will be available for the entire TRMM period (January 1998-present) by the end of 2004. The real-time version of this merged product has been produced over the past two years and is available on the U.S. TRMM web site (trmm.gsfc.nasa.gov) at 0.25" latitude-longitude resolution over the latitude range from 5O0N-50"S. Validation of daily totals indicates good results, with limitations noted in mid-latitude winter over land and regions of shallow, orographic precipitation. Various applications of these estimates are described, includmg: 1) detecting potential floods in near real-time; 2) analyzing Indian Ocean precipitation variations related to the initiation of El Nino; 3) determining characteristics of the African monsoon; and 4) analysis of diurnal variations.

  9. Music and Sound Elements in Time Estimation and Production of Children with Attention Deficit/Hyperactivity Disorder (ADHD

    Directory of Open Access Journals (Sweden)

    Luiz Rogerio Jorgensen Carrer

    2015-09-01

    Full Text Available ADHD involves cognitive and behavioral aspects with impairments in many environments of children and their families’ lives. Music, with its playful, spontaneous, affective, motivational, temporal and rhythmic dimensions can be of great help for studying the aspects of time processing in ADHD. In this article we studied time processing with simple sounds and music in children with ADHD with the hypothesis that children with ADHD have a different performance when compared with children with normal development in tasks of time estimation and production. The main objective was to develop sound and musical tasks to evaluate and correlate the performance of children with ADHD, with and without methylphenidate, compared to a control group with typical development. The study involved 36 participants age 6 to 14 years, recruited at NANI-Unifesp/SP, sub-divided into three groups with 12 children in each. Data was collected through a musical keyboard using Logic Audio Software 9.0 on the computer that recorded the participant's performance in the tasks. Tasks were divided into sections: spontaneous time production, time estimation with simple sounds and time estimation with music. Results: 1. Performance of ADHD groups in temporal estimation of simple sounds in short time intervals (30 ms were statistically lower than control group (p<0,05; 2. In the task comparing musical excerpts of the same duration (7s, ADHD groups considered the tracks longer when the musical notes had longer durations, while in the control group, the duration was related to the density of musical notes in the track. The positive average performance observed in the three groups in most tasks perhaps indicates the possibility that music can, in some way, positively modulate the symptoms of inattention in ADHD.

  10. Fathers' child care involvement and children's age in Spain: a time use study on differences by education and mothers' employment

    NARCIS (Netherlands)

    Gracia, P.

    2014-01-01

    Using time-diary data from the ‘2003 Spanish Time Use Survey’ (N = 2,941), I analysed two critical questions related to child development and gender equity. First, how do fathers of different levels of education adjust their parenting activities to their children’s developmental needs? Second, how

  11. Cortisol production patterns in young children living with birth parents vs children placed in foster care following involvement of Child Protective Services.

    Science.gov (United States)

    Bernard, Kristin; Butzin-Dozier, Zachary; Rittenhouse, Joseph; Dozier, Mary

    2010-05-01

    To examine differences in waking to bedtime cortisol production between children who remained with birth parents vs children placed in foster care following involvement of Child Protective Services (CPS). Between-subject comparison of cortisol patterns among 2 groups of children. Children referred from the child welfare system. Three hundred thirty-nine children aged 2.9 to 31.4 months who were living with birth parents (n = 155) or placed in foster care (n = 184) following CPS involvement as well as 96 unmatched children from low-risk environments. Main Exposures Involvement by CPS and foster care. Main Outcome Measure Salivary cortisol samples obtained at waking and bedtime for children on 2 days. Child Protective Services-involved children who continued to live with birth parents and CPS-involved children placed in foster care differed in cortisol production, with children living with their birth parents showing flatter slopes in waking to bedtime values. Continuing to live with birth parents following involvement of CPS is associated with greater perturbation to the diurnal pattern of cortisol production than living with foster parents. Foster care may have a regulating influence on children's cortisol among children who have experienced maltreatment.

  12. Productivity for librarians how to get more done in less time

    CERN Document Server

    Hines, Samantha

    2010-01-01

    Productivity for Librarians provides tips and tools for organizing, prioritizing and managing time along with reducing stress. The book presents a resources guide for continued learning about and exploration of productivity in relation to individual circumstances featuring motivation, procrastination and time management guidelines. Addressing the unique challenges faced by librarians, the author supplies a balanced view of a variety of tools and techniques for dealing with overwork and stress.there are many books on productivity, but none specifically targeted at library workers. We face uniqu

  13. Characterizing Global Flood Wave Travel Times to Optimize the Utility of Near Real-Time Satellite Remote Sensing Products

    Science.gov (United States)

    Allen, G. H.; David, C. H.; Andreadis, K. M.; Emery, C. M.; Famiglietti, J. S.

    2017-12-01

    Earth observing satellites provide valuable near real-time (NRT) information about flood occurrence and magnitude worldwide. This NRT information can be used in early flood warning systems and other flood management applications to save lives and mitigate flood damage. However, these NRT products are only useful to early flood warning systems if they are quickly made available, with sufficient time for flood mitigation actions to be implemented. More specifically, NRT data latency, or the time period between the satellite observation and when the user has access to the information, must be less than the time it takes a flood to travel from the flood observation location to a given downstream point of interest. Yet the paradigm that "lower latency is always better" may not necessarily hold true in river systems due to tradeoffs between data latency and data quality. Further, the existence of statistical breaks in the global distribution of flood wave travel time (i.e. a jagged statistical distribution) would represent preferable latencies for river-observation NRT remote sensing products. Here we present a global analysis of flood wave velocity (i.e. flow celerity) and travel time. We apply a simple kinematic wave model to a global hydrography dataset and calculate flow wave celerity and travel time during bankfull flow conditions. Bankfull flow corresponds to the condition of maximum celerity and thus we present the "worst-case scenario" minimum flow wave travel time. We conduct a similar analysis with respect to the time it takes flood waves to reach the next downstream city, as well as the next downstream reservoir. Finally, we conduct these same analyses, but with regards to the technical capabilities of the planned Surface Water and Ocean Topography (SWOT) satellite mission, which is anticipated to provide waterbody elevation and extent measurements at an unprecedented spatial and temporal resolution. We validate these results with discharge records from paired

  14. The impact of product configurators on lead times in engineering-oriented companies

    DEFF Research Database (Denmark)

    Haug, Anders; Hvam, Lars; Mortensen, Niels Henrik

    2011-01-01

    This paper presents a study of how the use of product configurators affects business processes of engineering-oriented companies. A literature study shows that only a minor part of product configuration research deals with the effects of product configuration, and that the ones that do are mostly...... vague when reporting the effects of configurator projects. Only six cases were identified, which provide estimates of the actual size of lead time reduction achieved from product configurators. To broaden this knowledge, this paper presents the results of a study of 14 companies concerning the impact...

  15. Radioactive characterization of the main materials involved in the titanium dioxide production process and their environmental radiological impact.

    Science.gov (United States)

    Mantero, J; Gazquez, M J; Bolivar, J P; Garcia-Tenorio, R; Vaca, F

    2013-06-01

    A study about the distribution of several radionuclides from the uranium and the thorium series radionuclides along the production process of a typical NORM industry devoted to the production of titanium dioxide has been performed. With this end the activity concentrations in raw materials, final product, co-products, and wastes of the production process have been determined by both gamma-ray and alpha-particle spectrometry. The main raw material used in the studied process (ilmenite) presents activity concentrations of around 300 Bq kg(-1) for Th-series radionuclides and 100 Bq kg(-1) for the U-series ones. These radionuclides in the industrial process are distributed in the different steps of the production process according mostly to the chemical behaviour of each radioelement, following different routes. As an example, most of the radium remains associated with the un-dissolved material waste, with activity concentrations around 3 kBq kg(-1) of (228)Ra and around 1 kBq kg(-1) of (226)Ra, while the final commercial products (TiO2 pigments and co-products) contain negligible amounts of radioactivity. The obtained results have allowed assessing the possible public radiological impact associated with the use of the products and co-products obtained in this type of industry, as well as the environmental radiological impact associated with the solid residues and liquid generated discharges. Copyright © 2013 Elsevier Ltd. All rights reserved.

  16. Use of dwell time concept in fission product inventory assessment for CANDU reactors

    International Nuclear Information System (INIS)

    Bae, C.J.; Choi, J.H.; Hwang, H.R.; Seo, J.T.

    2003-01-01

    A realistic approach in calculating the initial fission product inventory within the CANFLEX-NU fuel has been assessed for its applicability to the single channel event safety analysis for CANDU reactors. This approach is based on the dwell time concept in which the accident is assumed to occur at the dwell time when the summation of fission product inventory for all isotopes becomes largest. However, in the current conservative analysis, the maximum total inventory and the corresponding gap inventory for each isotope are used as the initial fission product inventories regardless of the accident initiation time. The fission product inventory analysis has been performed using ELESTRES code considering power histories and burnup of the fuel bundles in the limiting channel. The analysis results showed that the total fission product inventory is found to be largest at 20% dwell time. Therefore, the fission product inventory at 20% dwell time can be used as the initial condition for the single channel event for the CANDU 6 reactors. (author)

  17. Assessment of Multiple GNSS Real-Time SSR Products from Different Analysis Centers

    Directory of Open Access Journals (Sweden)

    Zhiyu Wang

    2018-03-01

    Full Text Available The real-time State Space Representation (SSR product of the GNSS (Global Navigation Satellite System orbit and clock is one of the most essential corrections for real-time precise point positioning (PPP. In this work, the performance of current SSR products from eight analysis centers were assessed by comparing it with the final product and the accuracy of real-time PPP. Numerical results showed that (1 the accuracies of the GPS SSR product were better than 8 cm for the satellite orbit and 0.3 ns for the satellite clock; (2 the accuracies of the GLONASS (GLObalnaya NAvigatsionnaya Sputnikovaya Sistema SSR product were better than 10 cm for orbit RMS (Root Mean Square and 0.6 ns for clock STD (Standard Deviation; and (3 the accuracies of the BDS (BeiDou Navigation Satellite System and Galileo SSR products from CLK93 were about 14.54 and 4.42 cm for the orbit RMS and 0.32 and 0.18 ns for the clock STD, respectively. The simulated kinematic PPP results obtained using the SSR products from CLK93 and CLK51 performed better than those using other SSR products; and the accuracy of PPP based on all products was better than 6 and 10 cm in the horizontal and vertical directions, respectively. The real-time kinematic PPP experiment carried out in Beijing, Tianjin, and Shijiazhuang, China indicated that the SSR product CLK93 from Centre National d’Etudes Spatiales (CNES had a better performance than CAS01. Moreover, the PPP with GPS + BDS dual systems had a higher accuracy than those with only a GPS single system.

  18. Computational procedure of optimal inventory model involving controllable backorder rate and variable lead time with defective units

    Science.gov (United States)

    Lee, Wen-Chuan; Wu, Jong-Wuu; Tsou, Hsin-Hui; Lei, Chia-Ling

    2012-10-01

    This article considers that the number of defective units in an arrival order is a binominal random variable. We derive a modified mixture inventory model with backorders and lost sales, in which the order quantity and lead time are decision variables. In our studies, we also assume that the backorder rate is dependent on the length of lead time through the amount of shortages and let the backorder rate be a control variable. In addition, we assume that the lead time demand follows a mixture of normal distributions, and then relax the assumption about the form of the mixture of distribution functions of the lead time demand and apply the minimax distribution free procedure to solve the problem. Furthermore, we develop an algorithm procedure to obtain the optimal ordering strategy for each case. Finally, three numerical examples are also given to illustrate the results.

  19. Re-orientating time in product design : a phenomenology-inspired perspective

    NARCIS (Netherlands)

    Stienstra, J.T.; Hengeveld, B.J.; Hummels, C.C.M.

    2015-01-01

    This paper presents a work in progress design case that is used to exemplify how a phenomenology-inspired perspective on time can impact the design of highly interactive systems and products. The design presents a calendar with a re-orientated layout that is based on a bodily relationship with time,

  20. Estimating primary production from oxygen time series: A novel approach in the frequency domain

    NARCIS (Netherlands)

    Cox, T.J.S.; Maris, T.; Soetaert, K.; Kromkamp, J.C.; Meire, P.; Meysman, F.J.R.

    2015-01-01

    Based on an analysis in the frequency domain of the governing equation of oxygen dynamics in aquatic systems, we derive a new method for estimating gross primary production (GPP) from oxygen time series. The central result of this article is a relation between time averaged GPP and the amplitude of

  1. Allocation and Productivity of Time in New Ventures of Female and Male Entrepreneurs

    NARCIS (Netherlands)

    I. Verheul (Ingrid); M.A. Carree (Martin); A.R. Thurik (Roy)

    2007-01-01

    textabstractThis paper investigates time allocation decisions in new ventures of female and male entrepreneurs using a model that distinguishes between effects of preferences and productivity on the number of working hours. Using data of 1,158 entrepreneurs we find that the preference for work time

  2. Allocation and productivity of time in new ventures of female and male entrepreneurs

    NARCIS (Netherlands)

    I. Verheul (Ingrid); M.A. Carree (Martin); A.R. Thurik (Roy)

    2009-01-01

    textabstractThis paper investigates time allocation decisions in new ventures of female and male entrepreneurs using a model that distinguishes between effects of preferences and productivity on the number of working hours. Using data of 1,158 entrepreneurs we find that the preference for work time

  3. Analysis of the Main Factors Influencing Food Production in China Based on Time Series Trend Chart

    Institute of Scientific and Technical Information of China (English)

    Shuangjin; WANG; Jianying; LI

    2014-01-01

    Based on the annual sample data on food production in China since the reform and opening up,we select 8 main factors influencing the total food production( growing area,application rate of chemical fertilizer,effective irrigation area,the affected area,total machinery power,food production cost index,food production price index,financial funds for supporting agriculture,farmers and countryside),and put them into categories of material input,resources and environment,and policy factors. Using the factor analysis,we carry out the multi-angle analysis of these typical influencing factors one by one through the time series trend chart. It is found that application rate of chemical fertilizer,the growing area of food crops and drought-affected area become the key factors affecting food production. On this basis,we set forth the corresponding recommendations for improving the comprehensive food production capacity.

  4. Single product lot-sizing on unrelated parallel machines with non-decreasing processing times

    Science.gov (United States)

    Eremeev, A.; Kovalyov, M.; Kuznetsov, P.

    2018-01-01

    We consider a problem in which at least a given quantity of a single product has to be partitioned into lots, and lots have to be assigned to unrelated parallel machines for processing. In one version of the problem, the maximum machine completion time should be minimized, in another version of the problem, the sum of machine completion times is to be minimized. Machine-dependent lower and upper bounds on the lot size are given. The product is either assumed to be continuously divisible or discrete. The processing time of each machine is defined by an increasing function of the lot volume, given as an oracle. Setup times and costs are assumed to be negligibly small, and therefore, they are not considered. We derive optimal polynomial time algorithms for several special cases of the problem. An NP-hard case is shown to admit a fully polynomial time approximation scheme. An application of the problem in energy efficient processors scheduling is considered.

  5. On the lag time between internal strain and basement involved thrust induced exhumation: The case of the Colombian Eastern Cordillera

    Science.gov (United States)

    Mora, Andrès; Blanco, Vladimir; Naranjo, Julian; Sanchez, Nelson; Ketcham, Richard A.; Rubiano, Jorge; Stockli, Daniel F.; Quintero, Isaid; Nemčok, Michal; Horton, Brian K.; Davila, Hamblet

    2013-07-01

    Thrust sheets accumulate internal strain before they start moving along discrete fault planes. However, there are no previous studies evaluating the time difference between initiation of strain and fault displacement. In this paper we use observations from the Eastern Cordillera of Colombia to evaluate this interval. We utilize multiple thermochronometers and paleothermometers to refine the timing of deformation. Based on these new data we build time-temperature path estimates that together with geometric outcrop-based structural analysis and fluid inclusions allow us to assign relative timing to features associated with strain, such as cleavage, veins and certain types of fractures, and compare that with the timing of thrusting. We find that cleavage was only formed close to maximum paleotemperatures, almost coeval with the onset of thrust-induced denudation by the Late Oligocene. The corresponding structural level of fold-related veins suggest that they were formed later but still when the country rocks were at temperatures higher than 160 °C, mostly during the Early Miocene and still coexisted with the latest stages of cleavage formation. Our data show that the main period of strain hardening was short (probably a few million years) and occurred before first-order basement thrusting was dominant, but was associated with second-order folding.

  6. The Role of Knowledge Acquisition in Facilitating Customer Involvement in Product Development: Examining the Mediation Effect of Absorptive Capacity

    Science.gov (United States)

    Dahiyat, Samer E.; Al-Zu'bi, Zu'bi M. F.

    2012-01-01

    Knowledge management has often been linked to product development, innovation, and customisation. In particular, effective exploitation of customer knowledge, through engaging customers in a process of co-creation of products, exemplifies such a link. Accordingly, this research aims to identify those dimensions of knowledge management activities…

  7. Leisure-time Physical Activity and Sedentary Behaviour in Older People: The Influence of Sport Involvement on Behaviour Patterns in Later Life.

    Science.gov (United States)

    Gayman, Amy M; Fraser-Thomas, Jessica; Spinney, Jamie E L; Stone, Rachael C; Baker, Joseph

    2017-01-01

    Given the dramatic demographic change underway in most industrialized nations, the health of older adults is a major concern, particularly given the prevalence of sedentary behaviours and physical inactivity among ageing populations. Researchers have suggested sport participation in later life promotes other health-related behaviours, however, these relationships are poorly understood. It is possible for individuals to be classified as sufficiently active and still spend most of their day involved in sedentary pursuits. Moreover, there is little information on older sport participants' use of time compared to leisurely active or inactive peers and whether type of physical activity involvement is associated with differences in older adults' behaviour patterns. With this in mind, data from 1,723 respondents (65 years and older) who completed the sport module of the 2010 Canadian General Social Survey-Time Use were used to investigate the influence of physical activity involvement (competitive sport vs. non-competitive sport vs. physically active leisure vs. inactivity) on time spent in leisure-time physical activity and sedentary behaviours. Results indicated that competitive sport participants spent less time engaging in sedentary behaviours compared to the physically active leisure or inactive respondents; however, sport participants (both competitive and non-competitive) also spent less time engaging in leisure-time physical activities than the physically active leisure group. Implications of these findings to assumptions related to the activity levels of older sport participants, suggestions for future research, and considerations for sport-related interventions aimed at enhancing health in older adulthood are discussed.

  8. An economic production model for deteriorating items and time dependent demand with rework and multiple production setups

    Science.gov (United States)

    Uthayakumar, R.; Tharani, S.

    2017-12-01

    Recently, much emphasis has given to study the control and maintenance of production inventories of the deteriorating items. Rework is one of the main issues in reverse logistic and green supply chain, since it can reduce production cost and the environmental problem. Many researchers have focused on developing rework model, but few of them have developed model for deteriorating items. Due to this fact, we take up productivity and rework with deterioration as the major concern in this paper. In this paper, a production-inventory model with deteriorative items in which one cycle has n production setups and one rework setup (n, 1) policy is considered for deteriorating items with stock-dependent demand in case 1 and exponential demand in case 2. An effective iterative solution procedure is developed to achieve optimal time, so that the total cost of the system is minimized. Numerical and sensitivity analyses are discussed to examine the outcome of the proposed solution procedure presented in this research.

  9. NADPH-dependent glutamate dehydrogenase in Penicillium chrysogenum is involved in regulation of beta-lactam production

    DEFF Research Database (Denmark)

    Thykær, Jette; Kildegaard, Kanchana Rueksomtawin; Noorman, H.

    2008-01-01

    was detected in either of the Delta gdhA strains. Supplementation with glutamate restored growth but no beta-lactam production was detected for the constructed strains. Cultures with high ammonium concentrations (repressing conditions) and with proline as nitrogen source (de-repressed conditions) showed......The interactions between the ammonium assimilatory pathways and beta-lactam production were investigated by disruption of the NADPH-dependent glutamate dehydrogenase gene (gdhA) in two industrial beta-lactam-producing strains of Penicillium chrysogenum. The strains used were an adipoyl-7-ADCA...... continued beta-lactam production for the reference strains whereas the Delta gdhA strains remained non-productive under all conditions. By overexpressing the NAD-dependent glutamate dehydrogenase, the specific growth rate could be restored, but still no beta-lactam production was detected. The results...

  10. The Effect Of Resting Time To Work Productivity On Surya Hutani Jaya Company

    Directory of Open Access Journals (Sweden)

    Purbawati

    2015-08-01

    Full Text Available Purbawati Rachmat M Ruslim Y B.D.A.S.Simarangkir. 2016. The Effect of resting time to work produktivity to the activity of Seedling Eucalyptus Pellitawith mini cutting.Productivity is the ratio between the output and the input. Rated productivity indicates how effectively the production process has been empowered to increase the output and how efficiently are also sources of input has been successfully saved. Many factors can affect productivity example is the resting time factor. In this study which examined is how the influence of rest periods of the Productivity and how much the standard output produced by the female labor force.Research conducted on women workers who are working at the cutting shoots cutting house.Nurseries with mini cutting process is done by cutting the of the leaves on each leaf so that the remaining 2 to 3 pairs of strands shoots that have undergone a process of cutting in its leaves called ready plant bud shoot. Ready plant bud is the output of this research while the input is the time used to do the cutting. This study aims to determine the influence of rest periods of the productivity of female workers and to determine the standard output produced by the female labor force. Data processing method used is the partial productivity measurement methods and measurement methods of working time. The results stated that the amount of labor productivity of women without giving time off is 0.0911 shoots second -1 whereas labor productivity by granting time off for 5 minutes every hour C1 by granting a 10 minute break every two hours C2 by granting time off for 30 minutes per one working day C3 by granting time off for 60 minutes per one working day C4 and the provision of rest periods combined mixed which is 5 minutes every hour and 60 minutes per one working day C5 respectively is 00908 shoots second -1 0.0761 shoots second-1 0.0972 shoots second-1 0.0857 shoots second-1 and 0.0860 shoots second -1. The calculation output

  11. Delimbing and Cross-cutting of Coniferous Trees–Time Consumption, Work Productivity and Performance

    Directory of Open Access Journals (Sweden)

    Arcadie Ciubotaru

    2018-04-01

    Full Text Available This research established the time consumption, work time structure, and productivity for primary processing in felling areas of coniferous trees felled with a chainsaw. Delimbing and partial cross-cutting were taken into consideration. The research was conducted in a mixed spruce and fir tree stand situated in the Carpathian Mountains. The team of workers consisted of a chainsaw operator and assistant with over 10 years of experience. The results indicated a total time of 536.32 s·m−3 (1145.26 s·tree−1, work performance (including delays of 6.716 m3·h−1 (3.14 tree·h−1, and work productivity (without delays of 35.459 m3·h−1 (16.58 tree·h−1. The chainsaw productivity during tree cross-cutting was 82.29 cm2·s−1. Delimbing accounted for 96.18% of the real work time, while cross-cutting accounted for 3.82%. The time consumption for delimbing and cross-cutting, as well as the work productivity and performance in the primary processing of coniferous trees in the felling area, were influenced by the breast height diameter, stem length, and tree volume, while the chainsaw productivity was influenced by the diameter of the cross-cut sections. The relationships between the aforementioned dependent and independent variables were determined by simple and linear multiple regression equations.

  12. Multilevel Production Systems with Dependent Demand with Uncertainty of Lead Times

    Directory of Open Access Journals (Sweden)

    Haibatolah Sadeghi

    2016-01-01

    Full Text Available This study considers a multilevel assembly system with several components in each sublevel. It is assumed that actual lead time for all components is probabilistic; and periodic order quantity (POQ policy for ordering is utilized. If at a certain level a job is not received at the expected time, a delay is incurred at the delivery of production at this level and this may result in backorders of the finished product. It is assumed in this case that a fixed percentage of the shortage is backlogged and other sales are lost. In the real situation, some but not all customers will wait for backlogged components during a period of shortage, such as for fashionable commodities or high-tech products with the short product life cycle. The objective of this study is to find the planned lead time and periodicity for the total components in order to minimize the expected fixed ordering, holding, and partial backlogging costs for the finished product. In this study, it is assumed that a percentage of components at each level are scrap. A general mathematical model is suggested and the method developed can be used for optimization planned lead time and periodicity for such an MRP system under lead time uncertainties.

  13. Improving Post-Hurricane Katrina Forest Management with MODIS Time Series Products

    Science.gov (United States)

    Lewis, Mark David; Spruce, Joseph; Evans, David; Anderson, Daniel

    2012-01-01

    Hurricane damage to forests can be severe, causing millions of dollars of timber damage and loss. To help mitigate loss, state agencies require information on location, intensity, and extent of damaged forests. NASA's MODerate Resolution Imaging Spectroradiometer (MODIS) Normalized Difference Vegetation Index (NDVI) time series data products offers a potential means for state agencies to monitor hurricane-induced forest damage and recovery across a broad region. In response, a project was conducted to produce and assess 250 meter forest disturbance and recovery maps for areas in southern Mississippi impacted by Hurricane Katrina. The products and capabilities from the project were compiled to aid work of the Mississippi Institute for Forest Inventory (MIFI). A series of NDVI change detection products were computed to assess hurricane induced damage and recovery. Hurricane-induced forest damage maps were derived by computing percent change between MODIS MOD13 16-day composited NDVI pre-hurricane "baseline" products (2003 and 2004) and post-hurricane NDVI products (2005). Recovery products were then computed in which post storm 2006, 2007, 2008 and 2009 NDVI data was each singularly compared to the historical baseline NDVI. All percent NDVI change considered the 16-day composite period of August 29 to September 13 for each year in the study. This provided percent change in the maximum NDVI for the 2 week period just after the hurricane event and for each subsequent anniversary through 2009, resulting in forest disturbance products for 2005 and recovery products for the following 4 years. These disturbance and recovery products were produced for the Mississippi Institute for Forest Inventory's (MIFI) Southeast Inventory District and also for the entire hurricane impact zone. MIFI forest inventory products were used as ground truth information for the project. Each NDVI percent change product was classified into 6 categories of forest disturbance intensity. Stand age

  14. Time-frequency analysis to a particular type of scattering problems involving metallic-polymer tubing structures.

    Science.gov (United States)

    Elhanaoui, Abdelkader; Aassif, Elhoucein; Maze, Gérard; Décultot, Dominique

    2018-01-01

    In this paper, recent studies of backscattered acoustic signals in thinner steel-polymer tubing structures have been presented. Reassigned smoothed pseudo Wigner-Ville (rspWV) analysis has been adopted in order to diminish the cross-term effect, and achieve high resolution spectral. Vibration modes, which are associated to the resonances of circumferential waves, have been determined by using the modal isolation plan representation. At normalized frequencies below 140, an appreciable influence from the polymer coating thickness on the A 0 + and S 0 modes has been noticed. Furthermore, the trajectory of the A 0 - wave has been modified in the normalized frequency band 40-42. Group velocity curves of the A 0 - wave have, then, been graphically illustrated. The findings have shown a particular curvature change at reduced frequency 41 in the case of an immersed two-layer tube in water. Studies of acoustic backscattering involving steel-polymer tubing structures have confirmed the significant coupling of A 0 + and S 0 waves. Besides, the disappearance of the A 0 + resonance trajectory has been observed; which is a very important phenomenon to understand. Copyright © 2017 Elsevier B.V. All rights reserved.

  15. Real-time PCR detection of Ochroconis lascauxensis involved in the formation of black stains in the Lascaux Cave, France.

    Science.gov (United States)

    Martin-Sanchez, Pedro M; Bastian, Fabiola; Alabouvette, Claude; Saiz-Jimenez, Cesareo

    2013-01-15

    A real-time Polymerase Chain Reaction (PCR) assay was developed to detect and quantify Ochroconis lascauxensis in the Lascaux Cave in France. This fungus is the principal causal agent of the black stains threatening the Paleolithic paintings of this UNESCO World Heritage Site. The black stains outbreak could not be stopped in spite of using intensive biocide treatments. A sensitive and time-saving protocol is needed for determining the extent of the colonization. Sets of primers that target the ITS and RPB2 regions were designed and evaluated for specificity against O. lascauxensis. Genomic DNA extracted from five species of Ochroconis and 13 other fungal species frequently isolated from caves were used to test the specificity of each primer set. The specific and sensitive real-time PCR assay using the primers 347F/493R targeting a 147-bp fragment from the RPB2 gene was useful for quantifying the presence of O. lascauxensis in the stains on the walls, sediments and air of the cavity. The results confirmed the association of this fungus with the black stains and its wide dissemination in all cave compartments. The suitability of this method for monitoring fungal outbreaks in cave environments is discussed. Copyright © 2012 Elsevier B.V. All rights reserved.

  16. A mixed-method analysis of free-time involvement and motivation among adolescents in Cape Town, South Africa

    Science.gov (United States)

    Palen, Lori-Ann; Caldwell, Linda L.; Smith, Edward A.; Gleeson, Sarah L.; Patrick, Megan E.

    2012-01-01

    Using focus group (N = 114) and survey (N = 946) data, this study employed Self-Determination Theory (SDT) as an organizing framework to examine free-time use and motivation among predominantly mixed-race adolescents from one area in South Africa. Adolescents reported participating in a broad range of activities, with socializing, media use, sports, risk behaviour, and performing arts being most frequently mentioned. All of the motivation types proposed by SDT were spontaneously mentioned by focus group participants. Free time was most strongly characterized by intrinsic motivations, such as competence, relatedness, and positive affect. Activities were also seen as a way to achieve outside goals. With few exceptions, multiple motivations were identified for the same activities, and specific motivations were reported across multiple activity types. The findings suggest that positive motivational experiences were not limited to a specific subset of activities. However, future longitudinal research on participation, motivation, and outcomes is needed to determine the developmental implications of different forms of free-time motivation. PMID:23055820

  17. Use of a free-jet expansion, molecular beam mass spectrometer to understand processes involving volatile corrosion products

    International Nuclear Information System (INIS)

    Jacobson, N.S.

    1997-01-01

    Many high-temperature corrosion processes generate volatile products in addition to condensed phase products. Examples of these volatile products are chlorides, oxychlorides, and certain oxides and hydroxyl species. One of the best techniques to identify high temperature vapor molecules is mass spectrometry. Most mass spectrometers operate in high vacuum and are generally used to examine processes ocurring at greatly reduced pressures. However, a free-jet expansion, molecular beam mass spectrometer system allows direct sampling of volatile corrosion products. This instrument is described. Several examples from our studies on chlorination/oxidation of metals and ceramics are discussed. In addition, reactions of Cr 2 O 3 , SiO 2 , and Al 2 O 3 with water vapor, which produce volatile hydroxyl species are discussed. (orig.)

  18. Real-Time Shop-Floor Production Performance Analysis Method for the Internet of Manufacturing Things

    Directory of Open Access Journals (Sweden)

    Yingfeng Zhang

    2014-04-01

    Full Text Available Typical challenges that manufacturing enterprises are facing now are compounded by lack of timely, accurate, and consistent information of manufacturing resources. As a result, it is difficult to analyze the real-time production performance for the shop-floor. In this paper, the definition and overall architecture of the internet of manufacturing things is presented to provide a new paradigm by extending the techniques of internet of things (IoT to manufacturing field. Under this architecture, the real-time primitive events which occurred at different manufacturing things such as operators, machines, pallets, key materials, and so forth can be easily sensed. Based on these distributed primitive events, a critical event model is established to automatically analyze the real-time production performance. Here, the up-level production performance analysis is regarded as a series of critical events, and the real-time value of each critical event can be easily calculated according to the logical and sequence relationships among these multilevel events. Finally, a case study is used to illustrate how to apply the designed methods to analyze the real-time production performance.

  19. Pair production in an electric field in a time-dependent gauge

    International Nuclear Information System (INIS)

    Barut, A.O.; Duru, I.H.

    1989-07-01

    A new nonperturbative method of calculation of the pair production in a constant electric field is presented in which the propagator is evaluated entirely by path-integration in a time-dependent potential. This gauge and the path integration correctly define all the normalizations. As a by-product we get also the Unruh formula since the constant electric field provides an accelerated frame. (author). 11 refs

  20. Analysis of phosphatidylcholine oxidation products in human plasma using quadrupole time-of flight mass spectrometry

    OpenAIRE

    Adachi, Junko; Asano, Migiwa; Yoshioka, Naoki; Nushida, Hideyuki; Ueno, Yasuhiro

    2006-01-01

    We report here an application of the previous method for the analysis ofphosphatidylcholine (PC) and lysophosphatidylcholine (lysoPC) oxidation products inhuman plasma using quadrupole time of flight (Q-TOF) mass spectrometry withelectrospray ionization. We separated these products using an HPLC C8 column witha gradient of methanol and 10 mM aqueous ammonium acetate. Monohydroperoxides,epoxyhydroxy derivatives, oxo derivatives, and trihydroxides of palmitoyl-linoleoyl(C16:0/C18:2) PC and stea...

  1. Pair production of Dirac particles in a d + 1-dimensional noncommutative space-time

    Energy Technology Data Exchange (ETDEWEB)

    Ousmane Samary, Dine [Perimeter Institute for Theoretical Physics, Waterloo, ON (Canada); University of Abomey-Calavi, International Chair in Mathematical Physics and Applications (ICMPA-UNESCO Chair), Cotonou (Benin); N' Dolo, Emanonfi Elias; Hounkonnou, Mahouton Norbert [University of Abomey-Calavi, International Chair in Mathematical Physics and Applications (ICMPA-UNESCO Chair), Cotonou (Benin)

    2014-11-15

    This work addresses the computation of the probability of fermionic particle pair production in d + 1-dimensional noncommutative Moyal space. Using Seiberg-Witten maps, which establish relations between noncommutative and commutative field variables, up to the first order in the noncommutative parameter θ, we derive the probability density of vacuum-vacuum pair production of Dirac particles. The cases of constant electromagnetic, alternating time-dependent, and space-dependent electric fields are considered and discussed. (orig.)

  2. String Chopping and Time-ordered Products of Linear String-localized Quantum Fields

    Science.gov (United States)

    Cardoso, Lucas T.; Mund, Jens; Várilly, Joseph C.

    2018-03-01

    For a renormalizability proof of perturbative models in the Epstein-Glaser scheme with string-localized quantum fields, one needs to know what freedom one has in the definition of time-ordered products of the interaction Lagrangian. This paper provides a first step in that direction. The basic issue is the presence of an open set of n-tuples of strings which cannot be chronologically ordered. We resolve it by showing that almost all such string configurations can be dissected into finitely many pieces which can indeed be chronologically ordered. This fixes the time-ordered products of linear field factors outside a nullset of string configurations. (The extension across the nullset, as well as the definition of time-ordered products of Wick monomials, will be discussed elsewhere).

  3. Harbor porpoise clicks do not have conditionally minimum time bandwidth product

    DEFF Research Database (Denmark)

    Beedholm, Kristian

    2008-01-01

    The hypothesis that odontocete clicks have minimal time frequency product given their delay and center frequency values is tested by using an in-phase averaged porpoise click compared with a pure tone weighted with the same envelope. These signals have the same delay and the same center frequency...... values but the time bandwidth product of the artificial click is only 0.76 that of the original. Therefore signals with the same parameters exist that have a lower time bandwidth product. The observation that porpoise clicks are in fact minimum phase is confirmed for porpoise clicks and this property...... is argued to be incompatible with optimal reception, if auditory filters are also minimum phase....

  4. Product Knowledge and Product Involvement as Moderators of the Effects of Information on Purchase Decisions: A Case Study Using the Perfect Information Frontier Approach.

    Science.gov (United States)

    Bei, Lien-Ti; Widdows, Richard

    1999-01-01

    Using a 2x2x2 factorial design, data from 282 respondents illustrate that people with more product knowledge ("experts") are more likely to be persuaded by complex than simple product information. "Novices" reacted similarly to simple and complex information. The type of information provided influences purchasing decisions. (SK)

  5. It's All about Timing: The Involvement of Kir4.1 Channel Regulation in Acute Ischemic Stroke Pathology

    Directory of Open Access Journals (Sweden)

    Meagan Milton

    2018-02-01

    Full Text Available An acute ischemic stroke is characterized by the presence of a blood clot that limits blood flow to the brain resulting in subsequent neuronal loss. Acute stroke threatens neuronal survival, which relies heavily upon proper function of astrocytes. Neurons are more susceptible to cell death when an astrocyte is unable to carry out its normal functions in supporting the neuron in the area affected by the stroke (Rossi et al., 2007; Takano et al., 2009. For example, under normal conditions, astrocytes initially swell in response to changes in extracellular osmotic pressure and then reduce their regulatory volume in response to volume-activated potassium (K+ and chloride channels (Vella et al., 2015. This astroglial swelling may be overwhelmed, under ischemic conditions, due to the increased levels of glutamate and extracellular K+ (Lai et al., 2014; Vella et al., 2015. The increase in extracellular K+ contributes to neuronal damage and loss through the initiation of harmful secondary cascades (Nwaobi et al., 2016. Reducing the amount of extracellular K+ could, in theory, limit or prevent neuronal damage and loss resulting in an improved prognosis for individuals following ischemic stroke. Kir4.1, an inwardly rectifying K+ channel, has demonstrated an ability to regulate the rapid reuptake of this ion to return the cell to basal levels allowing it to fire again in rapid transmission (Sibille et al., 2015. Despite growing interest in this area, the underlying mechanism suggesting that neuroprotection could occur through modification of the Kir4.1 channel's activity has yet to be described. The purpose of this review is to examine the current literature and propose potential underlying mechanisms involving Kir4.1, specially the mammalian target of rapamycin (mTOR and/or autophagic pathways, in the pathogenesis of ischemic stroke. The hope is that this review will instigate further investigation of Kir4.1 as a modulator of stroke pathology.

  6. A double-edged sword: the effects of challenge and hindrance time pressure on new product development teams

    NARCIS (Netherlands)

    Chong, D.S.F.; van Eerde, W.; Chai, K.H.; Rutte, C.G.

    2011-01-01

    Bringing new products to market requires team effort. New product development teams often face demanding schedules and high deliverable expectations, making time pressure a common experience at the workplace. Past literature have generally associated the relationship between time pressure and

  7. Order Level Inventory Models for Deteriorating Seasonable/Fashionable Products with Time Dependent Demand and Shortages

    Directory of Open Access Journals (Sweden)

    K. Skouri

    2009-01-01

    Full Text Available An order level inventory model for seasonable/fashionable products subject to a period of increasing demand followed by a period of level demand and then by a period of decreasing demand rate (three branches ramp type demand rate is considered. The unsatisfied demand is partially backlogged with a time dependent backlogging rate. In addition, the product deteriorates with a time dependent, namely, Weibull, deterioration rate. The model is studied under the following different replenishment policies: (a starting with no shortages and (b starting with shortages. The optimal replenishment policy for the model is derived for both the above mentioned policies.

  8. Part-time Work, Wages and Productivity:Evidence from Belgian Matched Panel Data

    OpenAIRE

    Garnero, Andrea; Kampelmann, Stephan; Rycx, François

    2013-01-01

    The authors use matched employer-employee panel data on Belgian private-sector firms to estimate the relationship between wage/productivity differentials and the firm’s labor composition in terms of part-time and sex. Findings suggest that the groups of women and part-timers generate employer rents, but also that the origin of these rents differs (relatively lower wages for women, relatively higher productivity for part-timers). Interactions between gender and part-time suggest that the posit...

  9. Analysis of oil-pipeline distribution of multiple products subject to delivery time-windows

    Science.gov (United States)

    Jittamai, Phongchai

    This dissertation defines the operational problems of, and develops solution methodologies for, a distribution of multiple products into oil pipeline subject to delivery time-windows constraints. A multiple-product oil pipeline is a pipeline system composing of pipes, pumps, valves and storage facilities used to transport different types of liquids. Typically, products delivered by pipelines are petroleum of different grades moving either from production facilities to refineries or from refineries to distributors. Time-windows, which are generally used in logistics and scheduling areas, are incorporated in this study. The distribution of multiple products into oil pipeline subject to delivery time-windows is modeled as multicommodity network flow structure and mathematically formulated. The main focus of this dissertation is the investigation of operating issues and problem complexity of single-source pipeline problems and also providing solution methodology to compute input schedule that yields minimum total time violation from due delivery time-windows. The problem is proved to be NP-complete. The heuristic approach, a reversed-flow algorithm, is developed based on pipeline flow reversibility to compute input schedule for the pipeline problem. This algorithm is implemented in no longer than O(T·E) time. This dissertation also extends the study to examine some operating attributes and problem complexity of multiple-source pipelines. The multiple-source pipeline problem is also NP-complete. A heuristic algorithm modified from the one used in single-source pipeline problems is introduced. This algorithm can also be implemented in no longer than O(T·E) time. Computational results are presented for both methodologies on randomly generated problem sets. The computational experience indicates that reversed-flow algorithms provide good solutions in comparison with the optimal solutions. Only 25% of the problems tested were more than 30% greater than optimal values and

  10. Real-Time Tropospheric Product Establishment and Accuracy Assessment in China

    Science.gov (United States)

    Chen, M.; Guo, J.; Wu, J.; Song, W.; Zhang, D.

    2018-04-01

    Tropospheric delay has always been an important issue in Global Navigation Satellite System (GNSS) processing. Empirical tropospheric delay models are difficult to simulate complex and volatile atmospheric environments, resulting in poor accuracy of the empirical model and difficulty in meeting precise positioning demand. In recent years, some scholars proposed to establish real-time tropospheric product by using real-time or near-real-time GNSS observations in a small region, and achieved some good results. This paper uses real-time observing data of 210 Chinese national GNSS reference stations to estimate the tropospheric delay, and establishes ZWD grid model in the country wide. In order to analyze the influence of tropospheric grid product on wide-area real-time PPP, this paper compares the method of taking ZWD grid product as a constraint with the model correction method. The results show that the ZWD grid product estimated based on the national reference stations can improve PPP accuracy and convergence speed. The accuracy in the north (N), east (E) and up (U) direction increase by 31.8 %,15.6 % and 38.3 %, respectively. As with the convergence speed, the accuracy of U direction experiences the most improvement.

  11. Analysis of the times involved in processing and communication in a lower limb simulation system controlled by SEMG

    Science.gov (United States)

    Profumieri, A.; Bonell, C.; Catalfamo, P.; Cherniz, A.

    2016-04-01

    Virtual reality has been proposed for different applications, including the evaluation of new control strategies and training protocols for upper limb prostheses and for the study of new rehabilitation programs. In this study, a lower limb simulation environment commanded by surface electromyography signals is evaluated. The time delays generated by the acquisition and processing stages for the signals that would command the knee joint, were measured and different acquisition windows were analysed. The subjective perception of the quality of simulation was also evaluated when extra delays were added to the process. The results showed that the acquisition window is responsible for the longest delay. Also, the basic implemented processes allowed for the acquisition of three signal channels for commanding the simulation. Finally, the communication between different applications is arguably efficient, although it depends on the amount of data to be sent.

  12. Optimal Consumer Electronics Product Take-Back Time with Consideration of Consumer Value

    Directory of Open Access Journals (Sweden)

    Yi-Tse Fang

    2017-03-01

    Full Text Available Rapid economic growth in recent years has transformed our lifestyle to massively produce, consume, and dispose of products, especially for consumer electronics. This change has put great threat to our environment and caused natural resource depletion. Moreover, short product life cycles and quick replacements of consumer electronics create enormous electronic wastes (e-wastes. Without proper waste management, immense environmental damage is expected. In this empirical study, we notice that lots of valuable materials that can still be recycled from these used consumer electronics are left unused at home instead of being recycled at the appropriate time, which causes a low collection rate and a decrease in residual value for the used products. Therefore, it is important for the government and the recyclers to handle them efficiently by increasing the used product take-back rate. Our study develops an assessment model for customer value based on the idea of value engineering and the perspective of product life cycle. We also explore the relationship between product value and the total cost of ownership with an evaluation of their time variation, considering different usage modes for various consumer groups and different recycling award schemes (fixed and variable recycling awards. Proper take-back management is likely to create a win-win situation both for consumers and environmental protection. This study regards the notebook computer as an example to determine the optimal time for recycling laptops based on usage patterns and provides consumers a reference for when to replace their used product. The results from our modeling firstly clearly indicate that consumers with higher frequency of usage have shorter take back times and higher maximum consumer value. Secondly, a variable recycling award scheme with higher maximum consumer value is more practical than a fixed recycling award scheme.

  13. Household production and consumption over the life cycle: National Time Transfer Accounts in 14 European countries

    Directory of Open Access Journals (Sweden)

    Lili Vargha

    2017-03-01

    Full Text Available Background: While the importance of unpaid household labour is recognised in total economic output, little is known about the demographics of household production and consumption. Objective: Our goal is to give a comprehensive estimation on the value of household production and its consumption by age and gender and analyse nonmarket economic transfers in 14 European countries based on publicly available harmonised data. Methods: We introduce a novel imputation method of harmonised European time use (HETUS data to the European Union Statistics on Income and Living Conditions (EU-SILC in order to assign time spent on home production to consumers in households and estimate time transfers. Moreover, monetary values are attributed to household production activities using data on earnings from the Structure of Earnings Survey (SES. Results: We show that the nonmarket economic life cycle of men differs from that of women. The gender gap in household production is not evenly distributed over the life cycle. Women of working age contribute the most in net terms, while the main beneficiaries of household goods and services are children and to a lesser extent adult men. These patterns are similar across countries, with variations in the gender- and age-specific levels of home production and consumption. Conclusions: In Europe, in the national economy, intergenerational flows are important in sustaining both childhood and old age. In contrast, in the household economy, intergenerational transfers flow mostly towards children. Contribution: We add a new focus to the research on household production: While keeping the gender aspect, we demonstrate the importance of the life cycle component in household production.

  14. Involvement of Physical Parameters in Medium Improvement for Tannase Production by Aspergillus niger FETL FT3 in Submerged Fermentation

    OpenAIRE

    Darah, I.; Sumathi, G.; Jain, K.; Hong, Lim Sheh

    2011-01-01

    Aspergillus niger FETL FT3, a local extracellular tannase producer strain that was isolated from one of dumping sites of tannin-rich barks of Rhizophora apiculata in Perak, Malaysia. This fungus was cultivated in 250 mL Erlenmeyer flask under submerged fermentation system. Various physical parameters were studied in order to maximize the tannase production. Maximal yield of tannase production, that is, 2.81 U per mL was obtained on the fourth day of cultivation when the submerged fermentation...

  15. A systematic literature review of Releasing Time to Care: The Productive Ward.

    Science.gov (United States)

    Wright, Stella; McSherry, Wilfred

    2013-05-01

    This systematic review provides an overview of the literature published on Releasing Time to Care: The Productive Ward between 2005 and June 2011. Releasing Time to Care: The Productive Ward programme was developed by the NHS Institute for Innovation and Improvement and launched in England in 2007. The programme comprises thirteen modules that aim to increase time for direct patient care, improve the patient and staff experience and make changes to the ward environment to improve efficiency. A systematic literature review. The terms 'Releasing Time to Care' and 'Productive Ward' were applied to key healthcare databases; CINAHL, Medline, Science Direct, ProQuest, Health Business Elite, British Nursing Index, Embase, Health Management Information Consortium and PsychInfo. All papers were read and subject to a quality assessment. The literature search identified 95 unique sources. A lack of research on The Productive Ward programme meant it was necessary to include non-empirical literature. In total, 18 articles met the inclusion criteria. Seven key themes were identified: the patient and staff experience, direct care time, patient safety, financial impact, embedding and sustainability, executive support and leadership, and common barriers and determinants of success. It also highlighted areas that require further exploration such as long-term sustainability of the programme and consistent data measurement between organisations. The review tentatively reports how The Productive Ward programme has been used to transform nursing practice for the benefit of patients and frontline staff, and how it resulted in cost savings. The literature review identified a potential positive results bias in the current literature whereby favourable outcomes were reported. This paper summarises the types of evidence and current literature on The Productive Ward providing a reference for frontline staff implementing the programme. © 2013 Blackwell Publishing Ltd.

  16. Online Time Series Analysis of Land Products over Asia Monsoon Region via Giovanni

    Science.gov (United States)

    Shen, Suhung; Leptoukh, Gregory G.; Gerasimov, Irina

    2011-01-01

    Time series analysis is critical to the study of land cover/land use changes and climate. Time series studies at local-to-regional scales require higher spatial resolution, such as 1km or less, data. MODIS land products of 250m to 1km resolution enable such studies. However, such MODIS land data files are distributed in 10ox10o tiles, due to large data volumes. Conducting a time series study requires downloading all tiles that include the study area for the time period of interest, and mosaicking the tiles spatially. This can be an extremely time-consuming process. In support of the Monsoon Asia Integrated Regional Study (MAIRS) program, NASA GES DISC (Goddard Earth Sciences Data and Information Services Center) has processed MODIS land products at 1 km resolution over the Asia monsoon region (0o-60oN, 60o-150oE) with a common data structure and format. The processed data have been integrated into the Giovanni system (Goddard Interactive Online Visualization ANd aNalysis Infrastructure) that enables users to explore, analyze, and download data over an area and time period of interest easily. Currently, the following regional MODIS land products are available in Giovanni: 8-day 1km land surface temperature and active fire, monthly 1km vegetation index, and yearly 0.05o, 500m land cover types. More data will be added in the near future. By combining atmospheric and oceanic data products in the Giovanni system, it is possible to do further analyses of environmental and climate changes associated with the land, ocean, and atmosphere. This presentation demonstrates exploring land products in the Giovanni system with sample case scenarios.

  17. MOPITT Near Real-Time Data for LANCE: Automatic Quality Assurance and Comparison to Operational Products

    Science.gov (United States)

    Martinez-Alonso, S.; Deeter, M. N.; Worden, H. M.; Ziskin, D.

    2017-12-01

    Terra-MOPITT (the Measurements of Pollution in the Troposphere instrument) near real-time (NRT) carbon monoxide (CO) products have been selected for distribution through NASA's LANCE (the Land, Atmosphere Near Real-Time Capability for EOS). MOPITT version 7 NRT data will be made publicly available within 3 hours from observation. The retrieval process is the same for both MOPITT NRT and operational products, albeit for the former it is constrained to use ancillary data available within the latency time. Among other requirements, LANCE NRT products must be examined for quality assurance (QA) purposes and relative errors between NRT and operational products must be quantified. Here we present an algorithm for automatic MOPITT NRT QA aimed to identify artifacts and separate those from anomalously high but real CO values. The algorithm is based on a comparison to the statistics of MOPITT operational products. We discuss the algorithm's performance when tested by applying it to three MOPITT datasets: a known (and corrected) artifact in version 4 operational data, anomalously high CO values in operational data during the 2015 Indonesia fires, and actual NRT data. Last, we describe results from a quantitative comparison between MOPITT NRT data and their operational counterparts.

  18. Continuous-Time Classical and Quantum Random Walk on Direct Product of Cayley Graphs

    International Nuclear Information System (INIS)

    Salimi, S.; Jafarizadeh, M. A.

    2009-01-01

    In this paper we define direct product of graphs and give a recipe for obtaining probability of observing particle on vertices in the continuous-time classical and quantum random walk. In the recipe, the probability of observing particle on direct product of graph is obtained by multiplication of probability on the corresponding to sub-graphs, where this method is useful to determining probability of walk on complicated graphs. Using this method, we calculate the probability of continuous-time classical and quantum random walks on many of finite direct product Cayley graphs (complete cycle, complete K n , charter and n-cube). Also, we inquire that the classical state the stationary uniform distribution is reached as t → ∞ but for quantum state is not always satisfied. (general)

  19. Assessment of MODIS NDVI time series data products for detecting forest defoliation by gypsy moth outbreaks

    Science.gov (United States)

    Joseph P. Spruce; Steven Sader; Robert E. Ryan; James Smoot; Philip Kuper; al. et.

    2011-01-01

    This paper discusses an assessment of Moderate Resolution Imaging Spectroradiometer (MODIS) time-series data products for detecting forest defoliation from European gypsy moth (Lymantria dispar). This paper describes an effort to aid the United States Department of Agriculture (USDA) Forest Service in developing and assessing MODIS-based gypsy moth defoliation...

  20. Covariance of time-ordered products implies local commutativity of fields

    International Nuclear Information System (INIS)

    Greenberg, O.W.

    2006-01-01

    We formulate Lorentz covariance of a quantum field theory in terms of covariance of time-ordered products (or other Green's functions). This formulation of Lorentz covariance implies spacelike local commutativity or anticommutativity of fields, sometimes called microscopic causality or microcausality. With this formulation microcausality does not have to be taken as a separate assumption

  1. The Impact of NPD Strategy, Product Strategy, and NPD Processes on Percieved Cycle Time

    NARCIS (Netherlands)

    Parry, Mark E.; Song, Michael; Song, Michael; de Weerd-Nederhof, Petronella C.; Visscher, Klaasjan

    2009-01-01

    Studies of new product development (NPD) have identified a variety of factors that influence cycle time, but most of these findings are based on case studies of individual firms. The few empirical studies that have attempted to examine the generalizability of these findings have tended to focus on

  2. Modelling maintenance practice of production plant using the delay-time concept

    NARCIS (Netherlands)

    Christer, A.H.; Wang, Wenbin; Baker, R.D.; Sharp, J.

    1995-01-01

    In this paper we present a study carried out for a copper products manufacturing company, developing and applying the delay-time modelling technique to model and thus optimize preventive maintenance (PM) of the plant. A key machine in the plant is used to illustrate the modelling process and

  3. Organisation of working time: Implications for productivity and working conditions. Overview Report

    NARCIS (Netherlands)

    Goudswaard, A.; Dhondt, S.; Vergeer, R.; Oeij, P.; Leede, J. de; Adrichem, K. van C; Csizmadia, P.; Makó, C.; Illésy, M.; Tóth, A.

    2012-01-01

    Companies in search of improved productivity use a wide range of approaches, from financial incentives and skills upgrading and training to increased autonomy of individuals and teams. Working time flexibility has the added advantage in that it can benefit both workers and employers: it gives

  4. Body size and the timing of egg production in parasitoid wasps.

    NARCIS (Netherlands)

    Ellers, J.; Jervis, M.

    2003-01-01

    In insects several key fitness-related variables are positively correlated with intraspecific variation in body size, but little is known about size-related variation in the timing of egg production within species. Female insects are known to vary in the degree to which they concentrate egg

  5. Quantum and classical strong direct product theorems and optimal time-space tradeoffs

    NARCIS (Netherlands)

    H. Klauck (Hartmut); R. Spalek (Robert); R. M. de Wolf (Ronald)

    2007-01-01

    textabstractA strong direct product theorem says that if we want to compute $k$ independent instances of a function, using less than $k$ times the resources needed for one instance, then our overall success probability will be exponentially small in $k$. We establish such theorems for the

  6. RD networks and regional knowledge production in Europe : Evidence from a space-time model

    NARCIS (Netherlands)

    Wanzenböck, Iris; Piribauer, Philipp

    2018-01-01

    In this study we estimate space-time impacts of the embeddedness in R&D networks on regional knowledge production using a dynamic spatial panel data model with non-linear effects for 229 European NUTS 2 regions in the period 1998–2010. Embeddedness refers to the positioning in networks where nodes

  7. Time characteristics of distortion product otoacoustic emissions recovery function after moderate sound exposure

    DEFF Research Database (Denmark)

    de Toro, Miguel Angel Aranda; Ordoñez, Rodrigo Pizarro; Hammershøi, Dorte

    2006-01-01

    Exposure to sound of moderate level temporarily attenuates the amplitude of distortion product otoacoustic emissions (DPOAEs). These changes are similar to the changes observed in absolute hearing thresholds after similar sound exposures. To be able to assess changes over time across a broad...

  8. Leisure-time Physical Activity and Sedentary Behaviour in Older People: The Influence of Sport Involvement on Behaviour Patterns in Later Life

    Directory of Open Access Journals (Sweden)

    Amy M. Gayman

    2017-05-01

    Full Text Available Given the dramatic demographic change underway in most industrialized nations, the health of older adults is a major concern, particularly given the prevalence of sedentary behaviours and physical inactivity among ageing populations. Researchers have suggested sport participation in later life promotes other health-related behaviours, however, these relationships are poorly understood. It is possible for individuals to be classified as sufficiently active and still spend most of their day involved in sedentary pursuits. Moreover, there is little information on older sport participants’ use of time compared to leisurely active or inactive peers and whether type of physical activity involvement is associated with differences in older adults’ behaviour patterns. With this in mind, data from 1,723 respondents (65 years and older who completed the sport module of the 2010 Canadian General Social Survey–Time Use were used to investigate the influence of physical activity involvement (competitive sport vs. non-competitive sport vs. physically active leisure vs. inactivity on time spent in leisure-time physical activity and sedentary behaviours. Results indicated that competitive sport participants spent less time engaging in sedentary behaviours compared to the physically active leisure or inactive respondents; however, sport participants (both competitive and non-competitive also spent less time engaging in leisure-time physical activities than the physically active leisure group. Implications of these findings to assumptions related to the activity levels of older sport participants, suggestions for future research, and considerations for sport-related interventions aimed at enhancing health in older adulthood are discussed.

  9. Effects of pollination timing and distance on seed production in a dioecious weed Silene latifolia

    Science.gov (United States)

    Anderson, Jay F.; Duddu, Hema S. N.; Shirtliffe, Steven J.; Benaragama, Dilshan; Syrovy, Lena D.; Stanley, Katherine A.; Haile, Teketel A.

    2015-11-01

    Silene latifolia Poir. (white cockle or white campion) is an important invasive weed in North American agriculture. It exhibits dioecy, therefore, both male and female plants are required in order for seed production to occur. However, dioecious species being invasive is not common because of their limitations in pollination and subsequent seed production. The objective of this study is to determine the effect of pollination timing and distance on seed production of Silene latifolia. A series of experiments including pollination exclusion, timing and pollination distance were conducted in 2009 and 2010 at or around Saskatoon, Saskatchewan. For pollination exclusion, exclosures were built around the natural female plants for exclosure, sham-exclosure, and male and female combined treatments. Pollination timing was studied by applying exclosure, non-exclosure, night-exclosure, and day-exclosure treatments to individual female plants. Female plants were transplanted along a linear interval at six different distances from the pollen source to study the effect of pollination distance. S. latifolia was exclusively insect-pollinated and pollination occurred both day and night; however, in one year, pollination occurred mainly at night. Female plants that were in the range of 0-4 m from a compatible pollen source experienced no limitation to pollination. However, when the distance was increased further up to 128 m, pollination levels and subsequent seed production were declined. Moreover, there were differences in seed production between years suggesting that pollination was affected by the environmental conditions during pollination and the crop that white cockle was grown in. These experiments indicate that seed production in S. latifolia is limited by insect-pollination. Although there was pollination limitation for seed production at greater distances from a pollen source, the high fecundity rate (3000-18000 seeds per plant) resulted in a large seed output. Thus, we

  10. Strategic WIP Inventory Positioning for Make-to-Order Production with Stochastic Processing Times

    Directory of Open Access Journals (Sweden)

    Jingjing Jiang

    2017-01-01

    Full Text Available It is vital for make-to-order manufacturers to shorten the lead time to meet the customers’ requirements. Holding work-in-process (WIP inventory at more stations can reduce the lead time, but it also brings about higher inventory holding cost. Therefore, it is important to seek out the optimal set of stations to hold WIP inventory to minimize the total inventory holding cost, while meeting the required due date for the final product at the same time. Since the problem with deterministic processing times at the stations has been addressed, as a natural extension, in this study, we address the problem with stochastic processing times, which is more realistic in the manufacturing environment. Assuming that the processing times follow normal distributions, we propose a solution procedure using genetic algorithm.

  11. Simvastatin attenuates acrolein-induced mucin production in rats: involvement of the Ras/extracellular signal-regulated kinase pathway.

    Science.gov (United States)

    Chen, Ya-Juan; Chen, Peng; Wang, Hai-Xia; Wang, Tao; Chen, Lei; Wang, Xun; Sun, Bei-Bei; Liu, Dai-Shun; Xu, Dan; An, Jing; Wen, Fu-Qiang

    2010-06-01

    Airway mucus overproduction is a cardinal feature of airway inflammatory diseases, such as chronic obstructive pulmonary disease and cystic fibrosis. Since the small G-protein Ras is known to modulate cellular functions in the lung, we sought to investigate whether the Ras inhibitor simvastatin could attenuate acrolein-induced mucin production in rat airways. Rats were exposed to acrolein for 12 days, after first being pretreated intragastrically for 24 h with either simvastatin alone or simvastatin in combination with mevalonate, which prevents the isoprenylation needed for Ras activation. Lung tissue was analyzed for extracellular signal-regulated kinase (ERK) activity, goblet cell metaplasia and mucin production. To analyze the effect of simvastatin on mucin production in more detail, acrolein-exposed human airway epithelial NCI-H292 cells were pretreated with simvastatin alone or together with mevalonate. Culture medium was collected to detect mucin secretion, and cell lysates were examined for Ras-GTPase activity and epidermal growth factor receptor (EGFR)/ERK phosphorylation. In vivo, simvastatin treatment dose-dependently suppressed acrolein-induced goblet cell hyperplasia and metaplasia in bronchial epithelium and inhibited ERK phosphorylation in rat lung homogenates. Moreover, simvastatin inhibited Muc5AC mucin synthesis at both the mRNA and protein levels in the lung. In vitro, simvastatin pretreatment attenuated the acrolein-induced significant increase in MUC5AC mucin expression, Ras-GTPase activity and EGFR/ERK phosphorylation. These inhibitory effects of simvastatin were neutralized by mevalonate administration both in vitro and in vivo. Our results suggest that simvastatin may attenuate acrolein-induced mucin protein synthesis in the airway and airway inflammation, possibly by blocking ERK activation mediated by Ras protein isoprenylation. Thus, the evidence from the experiment suggests that human trials are warranted to determine the potential

  12. Involvement of Physical Parameters in Medium Improvement for Tannase Production by Aspergillus niger FETL FT3 in Submerged Fermentation.

    Science.gov (United States)

    Darah, I; Sumathi, G; Jain, K; Hong, Lim Sheh

    2011-01-01

    Aspergillus niger FETL FT3, a local extracellular tannase producer strain that was isolated from one of dumping sites of tannin-rich barks of Rhizophora apiculata in Perak, Malaysia. This fungus was cultivated in 250 mL Erlenmeyer flask under submerged fermentation system. Various physical parameters were studied in order to maximize the tannase production. Maximal yield of tannase production, that is, 2.81 U per mL was obtained on the fourth day of cultivation when the submerged fermentation was carried out using liquid Czapek-Dox medium containing (percent; weight per volume) 0.25% NaNO(3), 0.1% KH(2)PO(4), 0.05% MgSO(4) ·7H(2)O, 0.05% KCl, and 1.0% tannic acid. The physical parameters used initial medium pH of 6.0, incubation temperature of 30°C, agitation speed of 200 rpm and inoculums size of 6 × 10(6) spores/ ml. This research has showed that physical parameters were influenced the tannase production by the fungus with 156.4 percent increment.

  13. Chloride stress triggers maturation and negatively affects the postharvest quality of persimmon fruit. Involvement of calyx ethylene production.

    Science.gov (United States)

    Besada, Cristina; Gil, Rebeca; Bonet, Luis; Quiñones, Ana; Intrigliolo, Diego; Salvador, Alejandra

    2016-03-01

    In recent years many hectares planted with persimmon trees in E Spain have been diagnosed with chloride toxicity. An effect of this abiotic stress on fruit quality has been reported in different crops. However, the impact of chloride stress on persimmon fruit quality is unknown. The harvest and postharvest quality of persimmons harvested from trees that manifest different intensities of chloride toxicity foliar symptoms was evaluated herein. Our results revealed that fruits from trees under chloride stress conditions underwent chloride accumulation in the calyx, which was more marked the greater the salt stress intensity trees were exposed to. Increased chloride concentrations in the calyx stimulated ethylene production in this tissue. In the fruits affected by slight and moderate chloride stress, calyx ethylene production accelerated the maturity process, as reflected by increased fruit colour and diminished fruit firmness. In the fruits under severe chloride stress, the high ethylene levels in the calyx triggered autocatalytic ethylene production in other fruit tissues, which led fruit maturity to drastically advance. In these fruits effectiveness of CO2 deastringency treatment was not complete and fruit softening enhanced during the postharvest period. Moreover, chloride stress conditions had a marked effect on reducing fruit weight, even in slightly stressed trees. Copyright © 2016 Elsevier Masson SAS. All rights reserved.

  14. Production Cells in Construction: Considering Time, Space and Information Linkages to Seek Broader Implementations

    Directory of Open Access Journals (Sweden)

    Renato Nunes Mariz

    2013-01-01

    Full Text Available The use of production cells in manufacturing has achieved many benefits, motivating researchers to apply them in the construction environment. The aim of this research is to identify time, space, and information linkages in construction’s production cells applications, seeking opportunities for broader implementations. We adopted a literature review approach focusing on cases in the Brazilian construction sector that addressed cell applications. Subsequently, comparative tables of these publications were prepared, analyzing the consideration of time, space, and information linkages, as well as identified results. The article pointed out that there is a gap in publications that address the application of a production cell in almost all construction flows, except the job site flow, reflecting the tendency of most companies of applying lean concepts firstly in physical flows. By analyzing these aspects (group of features that enhance the use of the cell, it was found that “material flow and pull systems” and “operators interaction” were the aspects most often considered, but mostly partially. Few cases reported the use of “flexibility” and “equipment maintenance”. No case reported comprehensive considerations of the three important linkages of time, space, and information. Space was the linkage better considered compared to time and information linkages. Lead time reduction, cost savings and increased productivity were among the greatest benefits reported from the applications of production cells. There is also a positive correlation between the linkages coverage and the number of benefits obtained. Further research is suggested in order to investigate the results of a more comprehensive application considering all linkages.

  15. Real time evolution at finite temperatures with operator space matrix product states

    International Nuclear Information System (INIS)

    Pižorn, Iztok; Troyer, Matthias; Eisler, Viktor; Andergassen, Sabine

    2014-01-01

    We propose a method to simulate the real time evolution of one-dimensional quantum many-body systems at finite temperature by expressing both the density matrices and the observables as matrix product states. This allows the calculation of expectation values and correlation functions as scalar products in operator space. The simulations of density matrices in inverse temperature and the local operators in the Heisenberg picture are independent and result in a grid of expectation values for all intermediate temperatures and times. Simulations can be performed using real arithmetics with only polynomial growth of computational resources in inverse temperature and time for integrable systems. The method is illustrated for the XXZ model and the single impurity Anderson model. (paper)

  16. Real time evolution at finite temperatures with operator space matrix product states

    Science.gov (United States)

    Pižorn, Iztok; Eisler, Viktor; Andergassen, Sabine; Troyer, Matthias

    2014-07-01

    We propose a method to simulate the real time evolution of one-dimensional quantum many-body systems at finite temperature by expressing both the density matrices and the observables as matrix product states. This allows the calculation of expectation values and correlation functions as scalar products in operator space. The simulations of density matrices in inverse temperature and the local operators in the Heisenberg picture are independent and result in a grid of expectation values for all intermediate temperatures and times. Simulations can be performed using real arithmetics with only polynomial growth of computational resources in inverse temperature and time for integrable systems. The method is illustrated for the XXZ model and the single impurity Anderson model.

  17. Involvement of the anterior cingulate cortex in time-based prospective memory task monitoring: An EEG analysis of brain sources using Independent Component and Measure Projection Analysis.

    Directory of Open Access Journals (Sweden)

    Gabriela Cruz

    Full Text Available Time-based prospective memory (PM, remembering to do something at a particular moment in the future, is considered to depend upon self-initiated strategic monitoring, involving a retrieval mode (sustained maintenance of the intention plus target checking (intermittent time checks. The present experiment was designed to explore what brain regions and brain activity are associated with these components of strategic monitoring in time-based PM tasks.24 participants were asked to reset a clock every four minutes, while performing a foreground ongoing word categorisation task. EEG activity was recorded and data were decomposed into source-resolved activity using Independent Component Analysis. Common brain regions across participants, associated with retrieval mode and target checking, were found using Measure Projection Analysis.Participants decreased their performance on the ongoing task when concurrently performed with the time-based PM task, reflecting an active retrieval mode that relied on withdrawal of limited resources from the ongoing task. Brain activity, with its source in or near the anterior cingulate cortex (ACC, showed changes associated with an active retrieval mode including greater negative ERP deflections, decreased theta synchronization, and increased alpha suppression for events locked to the ongoing task while maintaining a time-based intention. Activity in the ACC was also associated with time-checks and found consistently across participants; however, we did not find an association with time perception processing per se.The involvement of the ACC in both aspects of time-based PM monitoring may be related to different functions that have been attributed to it: strategic control of attention during the retrieval mode (distributing attentional resources between the ongoing task and the time-based task and anticipatory/decision making processing associated with clock-checks.

  18. A framework for public involvement at the design stage of NHS health and social care research: time to develop ethically conscious standards.

    Science.gov (United States)

    Pandya-Wood, Raksha; Barron, Duncan S; Elliott, Jim

    2017-01-01

    Researchers who conduct studies in health and social care are encouraged to involve the public as early as possible in the process of designing their studies. Before their studies are allowed to start researchers must seek approval from a Research Ethics Committee, which will assess whether the study is going to be safe and ethical for patients or healthy volunteers to take part in. The process of ethical review does not consider how researchers work with patients and the public early on to design their studies. Furthermore, there is no requirement for researchers to seek ethical approval for public involvement. However, in our work advising researchers about public involvement we have found that the ways in which researchers involve the public in the design of their studies are sometimes unintentionally unethical, and this is the focus of our paper. We have observed ten areas where ethical issues may arise because of the actions researchers may or may not take and which might consequently have a negative impact. Therefore, we have used these observations to develop a "framework" to help researchers and the public work together at the early design stage in ways that are ethical. Our intention for the framework is to help researchers be mindful of these ten areas and how easily ethical issues can arise. The framework suggests some ways to overcome the potential issues in each of the ten areas. The ten areas are: 1) Allocating sufficient time for public involvement; 2) Avoiding tokenism; 3) Registering research design stage public involvement work with NHS Research & Development Trust Office at earliest opportunity; 4) Communicating clearly from the outset; 5) Entitling public contributors to stop their involvement for any unstated reasons; 6) Operating fairness of opportunity; 7) Differentiating qualitative research methods and public involvement activities; 8) Working sensitively; 9) Being conscious of confidentiality and 10) Valuing, acknowledging and rewarding

  19. The effect of trainee involvement on procedure and list times: A statistical analysis with discussion of current issues affecting orthopaedic training in UK.

    Science.gov (United States)

    Wilson, T; Sahu, A; Johnson, D S; Turner, P G

    2010-02-01

    Training surgeons adds time to the duration of procedures and operation lists. This is not accounted for in the finance received to perform the operation by the hospital in the Payment by Results (PbR) system. To find out: 1. The effect on the duration of a procedure and the number of procedures performed on the list when a trainee is involved. 2. The percentage of orthopaedic cases with trainee involvement. 3. The effect of European working time directive (EWTD) on the trainee involvement in cases from theatre data in 2008 versus logbook data from 2004 - 2008. Data was taken from two different sources. Firstly, the Operating Room Information System (ORMIS) and patient operation notes. The second source was a consultant's logbook comprising 227 primary total knee replacements performed between 2004 and 2008. The data produced trends suggesting trainees took longer to perform procedures than consultants. In orthopaedic operations, 92% of cases had trainees present and of these 17% of cases were performed by trainees in 2008. Before the implementation of the EWTD, trainees performed more procedures when compared with current logbook data (38% versus 17% cases). Time taken by a trainee to perform the procedure under direct consultant supervision was significantly higher in comparison to procedures performed by a consultant alone (P = < 0.0001). Analysing the ORMIS and logbook data gave similar conclusions. Hospitals should be given financial recognition for training. In this debate, we should remain focused on the provision of quality training for the next generation of surgeons.

  20. ANALYZING THE POSTPONEMENT OF TIME PRODUCTION SYSTEMS IN MAKE-TO-STOCK AND SEASONAL DEMAND

    Directory of Open Access Journals (Sweden)

    Paulo Cesar Chagas Rodrigues

    2011-12-01

    Full Text Available The supply chain management, postponement and demand management functions are of strategic importance to the economic success of organizations because they influence the production process, when viewed in isolation and empirically may hinder understanding of their behavior. The aim of this paper is to analyze the influence of the postponement in an enterprise production system with make-to-stock and with seasonal demand. The research method used was a case study, the instruments of data collection were semi-structured interviews, documentary analysis and site visits. This research is restricted to analysis of the influence that different levels of delay and the company's position in the supply chain have on the practice of demand management in the productive segment graphic, product spiral notebook and also in relation to geographical focus (region of the state São Paulo, in which it will seek to interview the managers and directors. As a way to support the research on the analysis of case study and the final considerations will be discussed the following issues: supply chain management, postponement, demand management and production system make-to-stock. The demand management can be understood as a practice that allows you to manage and coordinate the supply chain in reverse, i.e. the consumer to the supplier, in which consumers trigger actions for the supply of products can make the process more efficient. The purpose of managing the supply chain is able to allow the addition of value, exceeding the expectations of consumers, it is necessary to develop a relationship with suppliers and customers win-win. The postponement strategy must fit the characteristics of the turbulent environment within the markets along with demands that require variety of customized products and services and reasonable costs, aiming to support decision making. The postponement of time can be a way to soften the increase in inventory of finished product in the company

  1. Pattern of leisure-time physical activity involvement of Academic and non-Academic staff in tertiary Institutions in Ondo State, Nigeria

    OpenAIRE

    Ajibua M.A.; Alla J.B

    2012-01-01

    Leisure signifies individual’s choice to spend his/her discretionary time fulfilling certain interest or needs or performing a gratifying experience for the sake of wellness or personal development. The aim of this study was to look into the pattern of leisure-time physical activity involvement among academic and non-academic staff in tertiary institution in Ondo State. For the purpose of the study, 40 academic and 40 non-academic staff were selected from the five Government-owned tertiary in...

  2. Use of Real Time Satellite Infrared and Ocean Color to Produce Ocean Products

    Science.gov (United States)

    Roffer, M. A.; Muller-Karger, F. E.; Westhaver, D.; Gawlikowski, G.; Upton, M.; Hall, C.

    2014-12-01

    Real-time data products derived from infrared and ocean color satellites are useful for several types of users around the world. Highly relevant applications include recreational and commercial fisheries, commercial towing vessel and other maritime and navigation operations, and other scientific and applied marine research. Uses of the data include developing sampling strategies for research programs, tracking of water masses and ocean fronts, optimizing ship routes, evaluating water quality conditions (coastal, estuarine, oceanic), and developing fisheries and essential fish habitat indices. Important considerations for users are data access and delivery mechanisms, and data formats. At this time, the data are being generated in formats increasingly available on mobile computing platforms, and are delivered through popular interfaces including social media (Facebook, Linkedin, Twitter and others), Google Earth and other online Geographical Information Systems, or are simply distributed via subscription by email. We review 30 years of applications and describe how we develop customized products and delivery mechanisms working directly with users. We review benefits and issues of access to government databases (NOAA, NASA, ESA), standard data products, and the conversion to tailored products for our users. We discuss advantages of different product formats and of the platforms used to display and to manipulate the data.

  3. Molecular quantification of lactic acid bacteria in fermented milk products using real-time quantitative PCR.

    Science.gov (United States)

    Furet, Jean-Pierre; Quénée, Pascal; Tailliez, Patrick

    2004-12-15

    Real-time quantitative PCR assays were developed for the absolute quantification of lactic acid bacteria (LAB) (Streptococcus thermophilus, Lactobacillus delbrueckii, L. casei, L. paracasei, L. rhamnosus, L. acidophilus and L. johnsonii) in fermented milk products. The results of molecular quantification and classic bacterial enumeration did not differ significantly with respect to S. thermophilus and the species of the L. casei group which were detected in the six commercial fermented products tested, thus showing that DNA extraction was efficient and that genomic DNA solutions were free of PCR inhibitors. For L. delbrueckii, the results of bacterial enumeration were generally lower by a factor 10 to 100 than those of PCR quantification, suggesting a loss of viability during storage of the dairy products at 1-8 degrees C for most of the strains in this species. Real-time quantitative assays enabled identification of the species of lactic acid bacterial strains initially present in commercial fermented milk products and their accurate quantification with a detection threshold of 10(3) cells per ml of product.

  4. Secondary analysis of a marketing research database reveals patterns in dairy product purchases over time.

    Science.gov (United States)

    Van Wave, Timothy W; Decker, Michael

    2003-04-01

    Development of a method using marketing research data to assess food purchase behavior and consequent nutrient availability for purposes of nutrition surveillance, evaluation of intervention effects, and epidemiologic studies of diet-health relationships. Data collected on household food purchases accrued over a 13-week period were selected by using Universal Product Code numbers and household characteristics from a marketing research database. Universal Product Code numbers for 39,408 dairy product purchases were linked to a standard reference for food composition to estimate the nutrient content of foods purchased over time. Two thousand one hundred sixty-one households located in Victoria, Texas, and surrounding communities who were active members of a frequent shopper program. Demographic characteristics of sample households and the nutrient content of their dairy product purchases were analyzed using frequency distribution, cross tabulation, analysis of variance, and t test procedures. A method for using marketing research data was successfully used to estimate household purchases of specific foods and their nutrient content from a marketing database containing hundreds of thousands of records. Distribution of dairy product purchases and their concomitant nutrients between Hispanic and non-Hispanic households were significant (P<.01, P<.001, respectively) and sustained over time. Purchase records from large, nationally representative panels of shoppers, such as those maintained by major market research companies, might be used to accomplish detailed longitudinal epidemiologic studies or surveillance of national food- and nutrient-purchasing patterns within and between countries and segments of their respective populations.

  5. Heavy Metals and Radioactive Characterization of the Main Materials Involved in the HC-FeMn Alloy Production Process

    Energy Technology Data Exchange (ETDEWEB)

    Badran, H. [Taif University (Saudi Arabia); Bakr, H.; Elnimr, T. [Tanta University (Egypt); Sharshar, T. [Kafrelsheikh University (Egypt)

    2014-07-01

    Natural occurring radioactive materials (NORM) are always present in association with a variety of elements in the geological formations. The extraction of non-radioactive minerals from the mineral matrices may lead to the buildup of NORM in wastes and/or end product with different concentrations of uranium and thorium daughters, depending on extraction procedures, initial concentrations and chemical forms of the NORM in the mineral matrices. Gamma-ray spectrometry was used for the quantitative assessment of radionuclides and the associated radiation hazards at the high carbon Ferromanganese alloy (HC-FeMn) production plant in Abu Zenima (West Sinai, Egypt). The low grad Mn from Um Bogma is mixed with Norwegian Mn to improve its quality. While the Egyptian raw Mn is richer in {sup 238}U, Cu and Zn, the Norwegian raw Mn is richer in {sup 40}K and Mn. The mixing process leads to increasing concentrations of {sup 226}Ra and Zn. Enhanced concentrations of Mn, Cu and Zn were also found in the waste. The radioactivity concentrations of {sup 226}Ra, {sup 232}Th and {sup 40}K in different raw materials used in the alloy formation process, HC-FeMn alloy, waste and other mining products produced by the same company are also determined. The estimated range of the total activities of wastes produced annually by the extraction process are 8.7-17.3, 0.7-1.3 and 6.7-13.4 GBq for {sup 226}Ra, {sup 232}Th and {sup 40}K, respectively. The calculated absorbed dose rate and the annual effective dose equivalent in waste dumps with these increased fractions of NORM are 225 nGy/h and 276 mSv, respectively. This investigation does not recommend the use of the waste in housing construction or as filling materials in the area where houses may be built on or near the tailing piles. Document available in abstract form only. (authors)

  6. Observation of double charm production involving open charm in pp collisions at $\\sqrt{s}$=7 TeV

    CERN Document Server

    Aaij, R; Adeva, B; Adinolfi, M; Adrover, C; Affolder, A; Ajaltouni, Z; Albrecht, J; Alessio, F; Alexander, M; Ali, S; Alkhazov, G; Alvarez Cartelle, P; Alves Jr, A A; Amato, S; Amhis, Y; Anderson, J; Appleby, R B; Aquines Gutierrez, O; Archilli, F; Artamonov, A; Artuso, M; Aslanides, E; Auriemma, G; Bachmann, S; Back, J J; Balagura, V; Baldini, W; Barlow, R J; Barschel, C; Barsuk, S; Barter, W; Bates, A; Bauer, C; Bauer, Th; Bay, A; Bediaga, I; Belogurov, S; Belous, K; Belyaev, I; Ben-Haim, E; Benayoun, M; Bencivenni, G; Benson, S; Benton, J; Bernet, R; Bettler, M -O; van Beuzekom, M; Bien, A; Bifani, S; Bird, T; Bizzeti, A; Bjørnstad, P M; Blake, T; Blanc, F; Blanks, C; Blouw, J; Blusk, S; Bobrov, A; Bocci, V; Bondar, A; Bondar, N; Bonivento, W; Borghi, S; Borgia, A; Bowcock, T J V; Bozzi, C; Brambach, T; van den Brand, J; Bressieux, J; Brett, D; Britsch, M; Britton, T; Brook, N H; Brown, H; Büchler-Germann, A; Burducea, I; Bursche, A; Buytaert, J; Cadeddu, S; Callot, O; Calvi, M; Calvo Gomez, M; Camboni, A; Campana, P; Carbone, A; Carboni, G; Cardinale, R; Cardini, A; Carson, L; Carvalho Akiba, K; Casse, G; Cattaneo, M; Cauet, Ch; Charles, M; Charpentier, Ph; Chiapolini, N; Ciba, K; Cid Vidal, X; Ciezarek, G; Clarke, P E L; Clemencic, M; Cliff, H V; Closier, J; Coca, C; Coco, V; Cogan, J; Collins, P; Comerma-Montells, A; Contu, A; Cook, A; Coombes, M; Corti, G; Couturier, B; Cowan, G A; Currie, R; D'Ambrosio, C; David, P; David, P N Y; De Bonis, I; De Bruyn, K; De Capua, S; De Cian, M; De Miranda, J M; De Paula, L; De Simone, P; Decamp, D; Deckenhoff, M; Degaudenzi, H; Del Buono, L; Deplano, C; Derkach, D; Deschamps, O; Dettori, F; Dickens, J; Dijkstra, H; Diniz Batista, P; Domingo Bonal, F; Donleavy, S; Dordei, F; Dosil Suárez, A; Dossett, D; Dovbnya, A; Dupertuis, F; Dzhelyadin, R; Dziurda, A; Easo, S; Egede, U; Egorychev, V; Eidelman, S; van Eijk, D; Eisele, F; Eisenhardt, S; Ekelhof, R; Eklund, L; Elsasser, Ch; Elsby, D; Esperante Pereira, D; Falabella, A; Färber, C; Fardell, G; Farinelli, C; Farry, S; Fave, V; Fernandez Albor, V; Ferro-Luzzi, M; Filippov, S; Fitzpatrick, C; Fontana, M; Fontanelli, F; Forty, R; Francisco, O; Frank, M; Frei, C; Frosini, M; Furcas, S; Gallas Torreira, A; Galli, D; Gandelman, M; Gandini, P; Gao, Y; Garnier, J-C; Garofoli, J; Garra Tico, J; Garrido, L; Gascon, D; Gaspar, C; Gauld, R; Gauvin, N; Gersabeck, M; Gershon, T; Ghez, Ph; Gibson, V; Gligorov, V V; Göbel, C; Golubkov, D; Golutvin, A; Gomes, A; Gordon, H; Grabalosa Gándara, M; Graciani Diaz, R; Granado Cardoso, L A; Graugés, E; Graziani, G; Grecu, A; Greening, E; Gregson, S; Gui, B; Gushchin, E; Guz, Yu; Gys, T; Hadjivasiliou, C; Haefeli, G; Haen, C; Haines, S C; Hampson, T; Hansmann-Menzemer, S; Harji, R; Harnew, N; Harrison, J; Harrison, P F; Hartmann, T; He, J; Heijne, V; Hennessy, K; Henrard, P; Hernando Morata, J A; van Herwijnen, E; Hicks, E; Holubyev, K; Hopchev, P; Hulsbergen, W; Hunt, P; Huse, T; Huston, R S; Hutchcroft, D; Hynds, D; Iakovenko, V; Ilten, P; Imong, J; Jacobsson, R; Jaeger, A; Jahjah Hussein, M; Jans, E; Jansen, F; Jaton, P; Jean-Marie, B; Jing, F; John, M; Johnson, D; Jones, C R; Jost, B; Kaballo, M; Kandybei, S; Karacson, M; Karbach, T M; Keaveney, J; Kenyon, I R; Kerzel, U; Ketel, T; Keune, A; Khanji, B; Kim, Y M; Knecht, M; Koopman, R F; Koppenburg, P; Korolev, M; Kozlinskiy, A; Kravchuk, L; Kreplin, K; Kreps, M; Krocker, G; Krokovny, P; Kruse, F; Kruzelecki, K; Kucharczyk, M; Kudryavtsev, V; Kvaratskheliya, T; La Thi, V N; Lacarrere, D; Lafferty, G; Lai, A; Lambert, D; Lambert, R W; Lanciotti, E; Lanfranchi, G; Langenbruch, C; Latham, T; Lazzeroni, C; Le Gac, R; van Leerdam, J; Lees, J -P; Lefèvre, R; Leflat, A; Lefrançois, J; Leroy, O; Lesiak, T; Li, L; Li Gioi, L; Lieng, M; Liles, M; Lindner, R; Linn, C; Liu, B; Liu, G; von Loeben, J; Lopes, J H; Lopez Asamar, E; Lopez-March, N; Lu, H; Luisier, J; Mac Raighne, A; Machefert, F; Machikhiliyan, I V; Maciuc, F; Maev, O; Magnin, J; Malde, S; Mamunur, R M D; Manca, G; Mancinelli, G; Mangiafave, N; Marconi, U; Märki, R; Marks, J; Martellotti, G; Martens, A; Martin, L; Martín Sánchez, A; Martinelli, M; Martinez Santos, D; Massafferri, A; Mathe, Z; Matteuzzi, C; Matveev, M; Maurice, E; Maynard, B; Mazurov, A; McGregor, G; McNulty, R; Meissner, M; Merk, M; Merkel, J; Miglioranzi, S; Milanes, D A; Minard, M -N; Molina Rodriguez, J; Monteil, S; Moran, D; Morawski, P; Mountain, R; Mous, I; Muheim, F; Müller, K; Muresan, R; Muryn, B; Muster, B; Mylroie-Smith, J; Naik, P; Nakada, T; Nandakumar, R; Nasteva, I; Needham, M; Neufeld, N; Nguyen, A D; Nguyen-Mau, C; Nicol, M; Niess, V; Nikitin, N; Nikodem, T; Nomerotski, A; Novoselov, A; Oblakowska-Mucha, A; Obraztsov, V; Oggero, S; Ogilvy, S; Okhrimenko, O; Oldeman, R; Orlandea, M; Otalora Goicochea, J M; Owen, P; Pal, B K; Palacios, J; Palano, A; Palutan, M; Panman, J; Papanestis, A; Pappagallo, M; Parkes, C; Parkinson, C J; Passaleva, G; Patel, G D; Patel, M; Paterson, S K; Patrick, G N; Patrignani, C; Pavel-Nicorescu, C; Pazos Alvarez, A; Pellegrino, A; Penso, G; Pepe Altarelli, M; Perazzini, S; Perego, D L; Perez Trigo, E; Pérez-Calero Yzquierdo, A; Perret, P; Perrin-Terrin, M; Pessina, G; Petrolini, A; Phan, A; Picatoste Olloqui, E; Pie Valls, B; Pietrzyk, B; Pilař, T; Pinci, D; Plackett, R; Playfer, S; Plo Casasus, M; Polok, G; Poluektov, A; Polycarpo, E; Popov, D; Popovici, B; Potterat, C; Powell, A; Prisciandaro, J; Pugatch, V; Puig Navarro, A; Qian, W; Rademacker, J H; Rakotomiaramanana, B; Rangel, M S; Raniuk, I; Raven, G; Redford, S; Reid, M M; dos Reis, A C; Ricciardi, S; Richards, A; Rinnert, K; Roa Romero, D A; Robbe, P; Rodrigues, E; Rodrigues, F; Rodriguez Perez, P; Rogers, G J; Roiser, S; Romanovsky, V; Rosello, M; Rouvinet, J; Ruf, T; Ruiz, H; Sabatino, G; Saborido Silva, J J; Sagidova, N; Sail, P; Saitta, B; Salzmann, C; Sannino, M; Santacesaria, R; Santamarina Rios, C; Santinelli, R; Santovetti, E; Sapunov, M; Sarti, A; Satriano, C; Satta, A; Savrie, M; Savrina, D; Schaack, P; Schiller, M; Schindler, H; Schleich, S; Schlupp, M; Schmelling, M; Schmidt, B; Schneider, O; Schopper, A; Schune, M -H; Schwemmer, R; Sciascia, B; Sciubba, A; Seco, M; Semennikov, A; Senderowska, K; Sepp, I; Serra, N; Serrano, J; Seyfert, P; Shapkin, M; Shapoval, I; Shatalov, P; Shcheglov, Y; Shears, T; Shekhtman, L; Shevchenko, O; Shevchenko, V; Shires, A; Silva Coutinho, R; Skwarnicki, T; Smith, N A; Smith, E; Sobczak, K; Soler, F J P; Solomin, A; Soomro, F; Souza De Paula, B; Spaan, B; Sparkes, A; Spradlin, P; Stagni, F; Stahl, S; Steinkamp, O; Stoica, S; Stone, S; Storaci, B; Straticiuc, M; Straumann, U; Subbiah, V K; Swientek, S; Szczekowski, M; Szczypka, P; Szumlak, T; T'Jampens, S; Teodorescu, E; Teubert, F; Thomas, C; Thomas, E; van Tilburg, J; Tisserand, V; Tobin, M; Tolk, S; Topp-Joergensen, S; Torr, N; Tournefier, E; Tourneur, S; Tran, M T; Tsaregorodtsev, A; Tuning, N; Ubeda Garcia, M; Ukleja, A; Uwer, U; Vagnoni, V; Valenti, G; Vazquez Gomez, R; Vazquez Regueiro, P; Vecchi, S; Velthuis, J J; Veltri, M; Viaud, B; Videau, I; Vieira, D; Vilasis-Cardona, X; Visniakov, J; Vollhardt, A; Volyanskyy, D; Voong, D; Vorobyev, A; Vorobyev, V; Voss, H; Waldi, R; Wandernoth, S; Wang, J; Ward, D R; Watson, N K; Webber, A D; Websdale, D; Whitehead, M; Wiedner, D; Wiggers, L; Wilkinson, G; Williams, M P; Williams, M; Wilson, F F; Wishahi, J; Witek, M; Witzeling, W; Wotton, S A; Wyllie, K; Xie, Y; Xing, F; Xing, Z; Yang, Z; Young, R; Yushchenko, O; Zangoli, M; Zavertyaev, M; Zhang, F; Zhang, L; Zhang, W C; Zhang, Y; Zhelezov, A; Zhong, L; Zvyagin, A

    2012-01-01

    The production of $J/\\psi$ mesons accompanied by open charm, and of pairs of open charm hadrons are observed in pp collisions at a centre-of-mass energy of 7 TeV using an integrated luminosity of $355pb^{-1}$ collected with the LHCb detector. Model independent measurements of absolute cross-sections are given together with ratios to the measured $J/\\psi$ and open charm cross-sections. The properties of these events are studied and compared to theoretical predictions.

  7. Shelf Life of Food Products: From Open Labeling to Real-Time Measurements.

    Science.gov (United States)

    Corradini, Maria G

    2018-03-25

    The labels currently used on food and beverage products only provide consumers with a rough guide to their expected shelf lives because they assume that a product only experiences a limited range of predefined handling and storage conditions. These static labels do not take into consideration conditions that might shorten a product's shelf life (such as temperature abuse), which can lead to problems associated with food safety and waste. Advances in shelf-life estimation have the potential to improve the safety, reliability, and sustainability of the food supply. Selection of appropriate kinetic models and data-analysis techniques is essential to predict shelf life, to account for variability in environmental conditions, and to allow real-time monitoring. Novel analytical tools to determine safety and quality attributes in situ coupled with modern tracking technologies and appropriate predictive tools have the potential to provide accurate estimations of the remaining shelf life of a food product in real time. This review summarizes the necessary steps to attain a transition from open labeling to real-time shelf-life measurements.

  8. Implementation of Lean System on Erbium Doped Fibre Amplifier Manufacturing Process to Reduce Production Time

    Science.gov (United States)

    Maneechote, T.; Luangpaiboon, P.

    2010-10-01

    A manufacturing process of erbium doped fibre amplifiers is complicated. It needs to meet the customers' requirements under a present economic status that products need to be shipped to customers as soon as possible after purchasing orders. This research aims to study and improve processes and production lines of erbium doped fibre amplifiers using lean manufacturing systems via an application of computer simulation. Three scenarios of lean tooled box systems are selected via the expert system. Firstly, the production schedule based on shipment date is combined with a first in first out control system. The second scenario focuses on a designed flow process plant layout. Finally, the previous flow process plant layout combines with production schedule based on shipment date including the first in first out control systems. The computer simulation with the limited data via an expected value is used to observe the performance of all scenarios. The most preferable resulted lean tooled box systems from a computer simulation are selected to implement in the real process of a production of erbium doped fibre amplifiers. A comparison is carried out to determine the actual performance measures via an analysis of variance of the response or the production time per unit achieved in each scenario. The goodness of an adequacy of the linear statistical model via experimental errors or residuals is also performed to check the normality, constant variance and independence of the residuals. The results show that a hybrid scenario of lean manufacturing system with the first in first out control and flow process plant lay out statistically leads to better performance in terms of the mean and variance of production times.

  9. EFFECT OF AGING TIME TOWARD CRYSTALLINITY OF PRODUCTS IN SYNTHESIS OF MESOPOROUS SILICATES MCM-41

    Directory of Open Access Journals (Sweden)

    Suyanta Suyanta

    2010-12-01

    Full Text Available Researches about the effects of aging time toward crystallinity of products in the synthesis of mesoporous silicates MCM-41 have been done. MCM-41 was synthesized by hydrothermal treatment to the mixture of sodium silicate, sodium hydroxide, cetyltrimetylammoniumbromide (CTMAB and aquadest in the molar ratio of 8Na2SiO3 : CTMAB : NaOH : 400H2O. Hydrothermal treatment was carried out at 110 °C in a teflon-lined stainless steel autoclave heated in the oven, with variation of aging time, i.e.: 4, 8, 12, 16, 24, 36, 48, and 72 h respectively. The solid phase were filtered, then washed with deionised water, and dried in the oven at 100 °C for 2 h. The surfactant CTMAB was removed by calcinations at 550 °C for 10 h with heating rate 2 °C/min. The as-synthesized and calcined powders were characterized by using FTIR spectroscopy and X-ray diffraction method. The relative crystallinity of products was evaluated based on the intensity of d100 peaks. The best product was characterized by using N2 physisorption method in order to determine the specific surface area, mean pore diameter, lattice parameter, and pore walls thickness. It was concluded that the relative crystallinity of the products was sensitively influenced by the aging time. The highest relative crystallinity was achieved when used 36 h of aging time in hydrothermal treatment. In this optimum condition the product has 946.607 m2g-1 of specific surface area, 3.357 nm of mean pore diameter, 4.533 nm of lattice parameter, and 1.176 nm of pore walls thickness.

  10. SpxA1 involved in hydrogen peroxide production, stress tolerance and endocarditis virulence in Streptococcus sanguinis.

    Directory of Open Access Journals (Sweden)

    Lei Chen

    Full Text Available Streptococcus sanguinis is one of the most common agents of infective endocarditis. Spx proteins are a group of global regulators that negatively or positively control global transcription initiation. In this study, we characterized the spxA1 gene in S. sanguinis SK36. The spxA1 null mutant displayed opaque colony morphology, reduced hydrogen peroxide (H(2O(2 production, and reduced antagonistic activity against Streptococcus mutans UA159 relative to the wild type strain. The ΔspxA1 mutant also demonstrated decreased tolerance to high temperature, acidic and oxidative stresses. Further analysis revealed that ΔspxA1 also exhibited a ∼5-fold reduction in competitiveness in an animal model of endocarditis. Microarray studies indicated that expression of several oxidative stress genes was downregulated in the ΔspxA1 mutant. The expression of spxB and nox was significantly decreased in the ΔspxA1 mutant compared with the wild type. These results indicate that spxA1 plays a major role in H(2O(2 production, stress tolerance and endocarditis virulence in S. sanguinis SK36. The second spx gene, spxA2, was also found in S. sanguinis SK36. The spxA2 null mutant was found to be defective for growth under normal conditions and showed sensitivity to high temperature, acidic and oxidative stresses.

  11. SpxA1 involved in hydrogen peroxide production, stress tolerance and endocarditis virulence in Streptococcus sanguinis.

    Science.gov (United States)

    Chen, Lei; Ge, Xiuchun; Wang, Xiaojing; Patel, Jenishkumar R; Xu, Ping

    2012-01-01

    Streptococcus sanguinis is one of the most common agents of infective endocarditis. Spx proteins are a group of global regulators that negatively or positively control global transcription initiation. In this study, we characterized the spxA1 gene in S. sanguinis SK36. The spxA1 null mutant displayed opaque colony morphology, reduced hydrogen peroxide (H(2)O(2)) production, and reduced antagonistic activity against Streptococcus mutans UA159 relative to the wild type strain. The ΔspxA1 mutant also demonstrated decreased tolerance to high temperature, acidic and oxidative stresses. Further analysis revealed that ΔspxA1 also exhibited a ∼5-fold reduction in competitiveness in an animal model of endocarditis. Microarray studies indicated that expression of several oxidative stress genes was downregulated in the ΔspxA1 mutant. The expression of spxB and nox was significantly decreased in the ΔspxA1 mutant compared with the wild type. These results indicate that spxA1 plays a major role in H(2)O(2) production, stress tolerance and endocarditis virulence in S. sanguinis SK36. The second spx gene, spxA2, was also found in S. sanguinis SK36. The spxA2 null mutant was found to be defective for growth under normal conditions and showed sensitivity to high temperature, acidic and oxidative stresses.

  12. Pattern of leisure-time physical activity involvement of Academic and non-Academic staff in tertiary Institutions in Ondo State, Nigeria

    Directory of Open Access Journals (Sweden)

    Ajibua M.A.

    2012-01-01

    Full Text Available Leisure signifies individual’s choice to spend his/her discretionary time fulfilling certain interest or needs or performing a gratifying experience for the sake of wellness or personal development. The aim of this study was to look into the pattern of leisure-time physical activity involvement among academic and non-academic staff in tertiary institution in Ondo State. For the purpose of the study, 40 academic and 40 non-academic staff were selected from the five Government-owned tertiary institutions in the state using convenience sampling techniques. Thus, total respondents were 400. The instrument employed in the study was a structured and validated questionnaire, Pattern of Leisure Involvement Questionnaire (PLIQ to collect information on the pattern of leisure-time physical activity involvement among staff. The reliability test of the instrument was carried out by obtaining Cronbach’s Alpha statistic which is a measure of how reliable and consistent the instrument was. The result showed that Cronbach’s Alpha was 0.896. Since the value was above 0.5 which was the average, it showed that the research instrument was reliable and consistent. The information gathered from the subjects through the questionnaire was analyzedusing descriptive (mean, standard deviation and standard error and inferential statistics (t-test. The findings showed that academic and non-academic staff in tertiary institutions in Ondo State participate in leisure-time physical activity differently. It thus suggested that variety of leisure-time physical activities must be provided for members of tertiary institutions so that some groups will not be taken care of, while others will be isolated.

  13. Portable inference engine: An extended CLIPS for real-time production systems

    Science.gov (United States)

    Le, Thach; Homeier, Peter

    1988-01-01

    The present C-Language Integrated Production System (CLIPS) architecture has not been optimized to deal with the constraints of real-time production systems. Matching in CLIPS is based on the Rete Net algorithm, whose assumption of working memory stability might fail to be satisfied in a system subject to real-time dataflow. Further, the CLIPS forward-chaining control mechanism with a predefined conflict resultion strategy may not effectively focus the system's attention on situation-dependent current priorties, or appropriately address different kinds of knowledge which might appear in a given application. Portable Inference Engine (PIE) is a production system architecture based on CLIPS which attempts to create a more general tool while addressing the problems of real-time expert systems. Features of the PIE design include a modular knowledge base, a modified Rete Net algorithm, a bi-directional control strategy, and multiple user-defined conflict resolution strategies. Problems associated with real-time applications are analyzed and an explanation is given for how the PIE architecture addresses these problems.

  14. Fusion of product and process data: Batch-mode and real-time streaming

    Energy Technology Data Exchange (ETDEWEB)

    Vincent De Sapio; Spike Leonard

    1999-12-01

    In today's DP product realization enterprise it is imperative to reduce the design-to-fabrication cycle time and cost while improving the quality of DP parts (reducing defects). Much of this challenge resides in the inherent gap between the product and process worlds. The lack of seamless, bi-directional flow of information prevents true concurrency in the product realization world. This report addresses a framework for product-process data fusion to help achieve next generation product realization. A fundamental objective is to create an open environment for multichannel observation of process date, and subsequent mapping of that data onto product geometry. In addition to the sensor-based observation of manufacturing processes, model-based process data provides an important complement to empirically acquired data. Two basic groups of manufacturing models are process physics, and machine kinematics and dynamics. Process physics addresses analytical models that describe the physical phenomena of the process itself. Machine kinematic and dynamic models address the mechanical behavior of the processing equipment. As a secondary objective, an attempt has been made in this report to address part of the model-based realm through the development of an open object-oriented library and toolkit for machine kinematics and dynamics. Ultimately, it is desirable to integrate design definition, with all types of process data; both sensor-based and model-based. Collectively, the goal is to allow all disciplines within the product realization enterprise to have a centralized medium for the fusion of product and process data.

  15. Joint Optimization of Economic Production Quantity and Preventive Maintenance with Considering Multi-Products and Reserve Time

    OpenAIRE

    Liu, Xuejuan; Wang, Binrong

    2017-01-01

    Purpose: We deal with the problem of the joint determination of optimal economic production quantity (EPQ) and optimal preventive maintenance (PM) for a system that can produce multiple products alternately. The objective is to find the optimal number of production cycles and the PM policy simultaneously by minimizing the cost model. Design/methodology/approach: Considering the products go through the system in a sequence and a complete run of all products forms a production cy...

  16. Ranking factors involved in product design using a hybrid model of Quality Function Deployment, Data Envelopment Analysis and TOPSIS technique

    Directory of Open Access Journals (Sweden)

    Davood Feiz

    2014-08-01

    Full Text Available Quality function deployment (QFD is one such extremely important quality management tool, which is useful in product design and development. Traditionally, QFD rates the design requirements (DRs with respect to customer requirements, and aggregates the rating to get relative importance score of DRs. An increasing number of studies emphasize on the need to incorporate additional factors, such as cost and environmental impact, while calculating the relative importance of DRs. However, there are different methodologies for driving the relative importance of DRs, when several additional factors are considered. TOPSIS (technique for order preferences by similarity to ideal solution is suggested for the purpose of the research. This research proposes new approach of TOPSIS for considering the rating of DRs with respect to CRs, and several additional factors, simultaneously. Proposed method is illustrated using by step-by-step procedure. The proposed methodology was applied for the Sanam Electronic Company in Iran.

  17. A cluster merging method for time series microarray with production values.

    Science.gov (United States)

    Chira, Camelia; Sedano, Javier; Camara, Monica; Prieto, Carlos; Villar, Jose R; Corchado, Emilio

    2014-09-01

    A challenging task in time-course microarray data analysis is to cluster genes meaningfully combining the information provided by multiple replicates covering the same key time points. This paper proposes a novel cluster merging method to accomplish this goal obtaining groups with highly correlated genes. The main idea behind the proposed method is to generate a clustering starting from groups created based on individual temporal series (representing different biological replicates measured in the same time points) and merging them by taking into account the frequency by which two genes are assembled together in each clustering. The gene groups at the level of individual time series are generated using several shape-based clustering methods. This study is focused on a real-world time series microarray task with the aim to find co-expressed genes related to the production and growth of a certain bacteria. The shape-based clustering methods used at the level of individual time series rely on identifying similar gene expression patterns over time which, in some models, are further matched to the pattern of production/growth. The proposed cluster merging method is able to produce meaningful gene groups which can be naturally ranked by the level of agreement on the clustering among individual time series. The list of clusters and genes is further sorted based on the information correlation coefficient and new problem-specific relevant measures. Computational experiments and results of the cluster merging method are analyzed from a biological perspective and further compared with the clustering generated based on the mean value of time series and the same shape-based algorithm.

  18. Implementation of anion-receptor macrocycles in supramolecular tandem assays for enzymes involving nucleotides as substrates, products, and cofactors.

    Science.gov (United States)

    Florea, Mara; Nau, Werner M

    2010-03-07

    A supramolecular tandem assay for direct continuous monitoring of nucleotide triphosphate-dependent enzymes such as potato apyrase is described. The underlying principle of the assay relies on the use of anion-receptor macrocycles in combination with fluorescent dyes as reporter pairs. A combinatorial approach was used to identify two complementary reporter pairs, i.e. an amino-gamma-cyclodextrin with 2-anilinonaphtalene-6-sulfonate (ANS) as dye (fluorescence enhancement factor of 17 upon complexation) and a polycationic cyclophane with 8-hydroxy-1,3,6-pyrene trisulfonate (HPTS) as dye (fluorescence decrease by a factor of more than 2000), which allow the kinetic monitoring of potato apyrase activity at different ATP concentration ranges (microM and mM) with different types of photophysical responses (switch-ON and switch-OFF). Competitive fluorescence titrations revealed a differential binding of ATP (strongest competitor) versus ADP and AMP, which constitutes the prerequisite for monitoring enzymatic conversions (dephosphorylation or phosphorylation) involving nucleotides. The assay was tested for different enzyme and substrate concentrations and exploited for the screening of activating additives, namely divalent transition metal ions (Ni(2+), Mg(2+), Mn(2+), and Ca(2+)). The transferability of the assay could be demonstrated by monitoring the dephosphorylation of other nucleotide triphosphates (GTP, TTP, and CTP).

  19. Target life time of laser ion source for low charge state ion production

    Energy Technology Data Exchange (ETDEWEB)

    Kanesue,T.; Tamura, J.; Okamura, M.

    2008-06-23

    Laser ion source (LIS) produces ions by irradiating pulsed high power laser shots onto the solid state target. For the low charge state ion production, laser spot diameter on the target can be over several millimeters using a high power laser such as Nd:YAG laser. In this case, a damage to the target surface is small while there is a visible crater in case of the best focused laser shot for high charge state ion production (laser spot diameter can be several tens of micrometers). So the need of target displacement after each laser shot to use fresh surface to stabilize plasma is not required for low charge state ion production. We tested target lifetime using Nd:YAG laser with 5 Hz repetition rate. Also target temperature and vacuum condition were recorded during experiment. The feasibility of a long time operation was verified.

  20. Investigation of the Time Evolution and Species Production in a 2-Dimensional Packed Bed Reactor

    Science.gov (United States)

    Engeling, Kenneth; Kruszelnicki, Juliusz; Kushner, Mark; Foster, John

    2016-09-01

    Plasma production in microporous media has potential to enable a number of technologies ranging from flameless combustion to environmental hazard mitigation addressing air borne pollutants. Packed bed reactors (PBRs) is one such technology that relies on plasma production in microporous media. The physics of plasma production and transport in such media however remains poorly understood. In order to better understand the plasma propagation and plasma driven chemical reaction within microporous media, absorption spectroscopy and time-resolved imaging diagnostics are being utilized. We report on plasma driven species formation and plasma discharge spatial structure and evolution characteristics found in the 2-dimensional representation of a PBR. Work supported by US DOE Office of Fusion Energy Science and the National Science Foundation.

  1. Exact and Heuristic Solutions to Minimize Total Waiting Time in the Blood Products Distribution Problem

    Directory of Open Access Journals (Sweden)

    Amir Salehipour

    2012-01-01

    Full Text Available This paper presents a novel application of operations research to support decision making in blood distribution management. The rapid and dynamic increasing demand, criticality of the product, storage, handling, and distribution requirements, and the different geographical locations of hospitals and medical centers have made blood distribution a complex and important problem. In this study, a real blood distribution problem containing 24 hospitals was tackled by the authors, and an exact approach was presented. The objective of the problem is to distribute blood and its products among hospitals and medical centers such that the total waiting time of those requiring the product is minimized. Following the exact solution, a hybrid heuristic algorithm is proposed. Computational experiments showed the optimal solutions could be obtained for medium size instances, while for larger instances the proposed hybrid heuristic is very competitive.

  2. Expertise, Time, Money, Mentoring, and Reward: Systemic Barriers That Limit Education Researcher Productivity-Proceedings From the AAMC GEA Workshop.

    Science.gov (United States)

    Yarris, Lalena M; Juve, Amy Miller; Artino, Anthony R; Sullivan, Gail M; Rougas, Steven; Joyce, Barbara; Eva, Kevin

    2014-09-01

    To further evolve in an evidence-based fashion, medical education needs to develop and evaluate new practices for teaching, learning, and assessment. However, educators face barriers in designing, conducting, and publishing education research. To explore the barriers medical educators face in formulating, conducting, and publishing high-quality medical education research, and to identify strategies for overcoming them. A consensus workshop was held November 5, 2013, at the Association of American Medical Colleges annual meeting. A working group of education research experts and educators completed a preconference literature review focusing on barriers to education research. During the workshop, consensus-based and small group techniques were used to refine the broad themes into content categories. Attendees then ranked the most important barriers and strategies for overcoming them with the highest potential impact. Barriers participants faced in conducting quality education research included lack of (1) expertise, (2) time, (3) funding, (4) mentorship, and (5) reward. The strategy considered most effective in overcoming these barriers involved building communities of education researchers for collaboration and networking, and advocating for education researchers' interests. Other suggestions included trying to secure increased funding opportunities, developing mentoring programs, and encouraging mechanisms to ensure protected time. Barriers to education research productivity clearly exist. Many appear to result from feelings of isolation that may be overcome with systemic efforts to develop and enable communities of practice across institutions. Finally, the theme of "reward" is novel and complex and may have implications for education research productivity.

  3. Research on the time optimization model algorithm of Customer Collaborative Product Innovation

    Directory of Open Access Journals (Sweden)

    Guodong Yu

    2014-01-01

    Full Text Available Purpose: To improve the efficiency of information sharing among the innovation agents of customer collaborative product innovation and shorten the product design cycle, an improved genetic annealing algorithm of the time optimization was presented. Design/methodology/approach: Based on the analysis of the objective relationship between the design tasks, the paper takes job shop problems for machining model and proposes the improved genetic algorithm to solve the problems, which is based on the niche technology and thus a better product collaborative innovation design time schedule is got to improve the efficiency. Finally, through the collaborative innovation design of a certain type of mobile phone, the proposed model and method were verified to be correct and effective. Findings and Originality/value: An algorithm with obvious advantages in terms of searching capability and optimization efficiency of customer collaborative product innovation was proposed. According to the defects of the traditional genetic annealing algorithm, the niche genetic annealing algorithm was presented. Firstly, it avoided the effective gene deletions at the early search stage and guaranteed the diversity of solution; Secondly, adaptive double point crossover and swap mutation strategy were introduced to overcome the defects of long solving process and easily converging local minimum value due to the fixed crossover and mutation probability; Thirdly, elite reserved strategy was imported that optimal solution missing was avoided effectively and evolution speed was accelerated. Originality/value: Firstly, the improved genetic simulated annealing algorithm overcomes some defects such as effective gene easily lost in early search. It is helpful to shorten the calculation process and improve the accuracy of the convergence value. Moreover, it speeds up the evolution and ensures the reliability of the optimal solution. Meanwhile, it has obvious advantages in efficiency of

  4. Influence of capacity- and time-constrained intermediate storage in two-stage food production systems

    DEFF Research Database (Denmark)

    Akkerman, Renzo; van Donk, Dirk Pieter; Gaalman, Gerard

    2007-01-01

    In food processing, two-stage production systems with a batch processor in the first stage and packaging lines in the second stage are common and mostly separated by capacity- and time-constrained intermediate storage. This combination of constraints is common in practice, but the literature hardly...... of systems like this. Contrary to the common sense in operations management, the LPT rule is able to maximize the total production volume per day. Furthermore, we show that adding one tank has considerable effects. Finally, we conclude that the optimal setup frequency for batches in the first stage...... pays any attention to this. In this paper, we show how various capacity and time constraints influence the performance of a specific two-stage system. We study the effects of several basic scheduling and sequencing rules in the presence of these constraints in order to learn the characteristics...

  5. Tensor-product preconditioners for higher-order space-time discontinuous Galerkin methods

    Science.gov (United States)

    Diosady, Laslo T.; Murman, Scott M.

    2017-02-01

    A space-time discontinuous-Galerkin spectral-element discretization is presented for direct numerical simulation of the compressible Navier-Stokes equations. An efficient solution technique based on a matrix-free Newton-Krylov method is developed in order to overcome the stiffness associated with high solution order. The use of tensor-product basis functions is key to maintaining efficiency at high-order. Efficient preconditioning methods are presented which can take advantage of the tensor-product formulation. A diagonalized Alternating-Direction-Implicit (ADI) scheme is extended to the space-time discontinuous Galerkin discretization. A new preconditioner for the compressible Euler/Navier-Stokes equations based on the fast-diagonalization method is also presented. Numerical results demonstrate the effectiveness of these preconditioners for the direct numerical simulation of subsonic turbulent flows.

  6. Tensor-Product Preconditioners for Higher-Order Space-Time Discontinuous Galerkin Methods

    Science.gov (United States)

    Diosady, Laslo T.; Murman, Scott M.

    2016-01-01

    space-time discontinuous-Galerkin spectral-element discretization is presented for direct numerical simulation of the compressible Navier-Stokes equat ions. An efficient solution technique based on a matrix-free Newton-Krylov method is developed in order to overcome the stiffness associated with high solution order. The use of tensor-product basis functions is key to maintaining efficiency at high order. Efficient preconditioning methods are presented which can take advantage of the tensor-product formulation. A diagonalized Alternating-Direction-Implicit (ADI) scheme is extended to the space-time discontinuous Galerkin discretization. A new preconditioner for the compressible Euler/Navier-Stokes equations based on the fast-diagonalization method is also presented. Numerical results demonstrate the effectiveness of these preconditioners for the direct numerical simulation of subsonic turbulent flows.

  7. Puerarin exerts antipyretic effect on lipopolysaccharide-induced fever in rats involving inhibition of pyrogen production from macrophages.

    Science.gov (United States)

    Yao, Xiu-Juan; Yin, Ji-Ai; Xia, Yu-Feng; Wei, Zhi-Feng; Luo, Yu-Bin; Liu, Mei; Feleder, Carlos; Dai, Yue

    2012-05-07

    Puerarin is the most abundant isoflavonoid in Radix Puerariae (Gegen), which has been prescribed as a medicinal herb for treating fever in China for a long history. The present study aimed at evaluating the antipyretic effect of puerarin and revealing the related mechanisms. Lipopolysaccharide (LPS)-induced fever in rats was used to assess the antipyretic effect of puerarin. After an intraperitoneal injection of LPS (100μg/kg), body temperature was tested every 30min up to 8h. Different doses of puerarin (25, 50, 100mg/kg) were intraperitoneally administered 30min before LPS injection. In vitro, LPS-stimulated RAW 264.7 cells were treated with various concentrations of puerarin (25-200μM). The pyrogenic mediators, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), prostaglandin E(2) (PGE(2)) and nitric oxide (NO), were examined on both transcription and expression levels. Furthermore, the influences of the activation of nuclear factor-kappa B (NF-κB) and the phosphorylation of mitogen-activated protein kinases (MAPKs) by puerarin were assayed by western blot. The intraperitoneal administration of puerarin at test doses clearly demonstrated apparent antipyretic effect through the declines in body temperature elevated by LPS in rats. The in vitro data showed that puerarin inhibited the production of IL-1β, TNF-α, IL-6, PGE(2) and NO; moreover, the RT-PCR analysis and the western blot analysis indicated that puerarin regulated the transcriptional level via suppression of NF-κB activation and blockade of MAPK signal pathway. In summary, the antipyretic property of puerarin might result, at least in part, from an inhibition of endogenous pyrogen production and expression. Taken in this sense, our findings provide an explanation for puerarin acting as an important constituent in Gegen, thus, provide scientific basis for the wide use of Radix Puerariae in China as a traditional antipyretic. Copyright © 2012 Elsevier Ireland

  8. Delay times between harvesting or collection of food products and consumption for use in radiological assessments

    International Nuclear Information System (INIS)

    Jones, A L; Sherwood, J C

    2009-01-01

    From a radiological protection point of view, the inclusion of delay times when carrying out assessments of dose from consumption of foods should be considered. A review of delay times has been carried out to update a report published in 1983, to take account of changes and modernisations in industrial food processes, together with changes in diet and popularity of different foods in the United Kingdom. The new review considered more foods and data for existing foods have been reconsidered to check whether manufacturing processes or procedures have changed the shelf-life of any products. For some foods there have been changes made to the recommended delay times because of changes in manufacture or handling of the fresh foodstuff. A discussion is also included on the appropriate use of delay times in dose assessments.

  9. Protective effect of Galectin-9 in murine model of lung emphysema: Involvement of neutrophil migration and MMP-9 production

    Science.gov (United States)

    Horio, Yuko; Ichiyasu, Hidenori; Kojima, Keisuke; Saita, Naoki; Migiyama, Yohei; Iriki, Toyohisa; Fujii, Kazuhiko; Niki, Toshiro; Hirashima, Mitsuomi; Kohrogi, Hirotsugu

    2017-01-01

    Purpose Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction and pulmonary emphysema. Persistent inflammation and remodeling of the lungs and airways result in reduced lung function and a lower quality of life. Galectin (Gal)-9 plays a crucial role as an immune modulator in various diseases. However, its role in the pathogenesis of pulmonary emphysema is unknown. This study investigates whether Gal-9 is involved in pulmonary inflammation and changes in emphysema in a porcine pancreatic elastase (PPE)-induced emphysema model. Materials and methods Gal-9 was administered to mice subcutaneously once daily from 1 day before PPE instillation to day 5. During the development of emphysema, lung tissue and bronchoalveolar lavage fluid (BALF) were collected. Histological and cytological findings, concentrations of chemokines and matrix metalloproteinases (MMPs) in the BALF, and the influence of Gal-9 treatment on neutrophils were analyzed. Results Gal-9 suppressed the pathological changes of PPE-induced emphysema. The mean linear intercept (Lm) of Gal-9-treated emphysema mice was significantly lower than that of PBS-treated emphysema mice (66.1 ± 3.3 μm vs. 118.8 ± 14.8 μm, respectively; p emphysema progressed significantly compared with that in wild–type (WT) mice (108.7 ± 6.58 μm vs. 77.19 ± 6.97 μm, respectively; p emphysema by inhibiting the infiltration of neutrophils and decreasing MMPs levels. Exogenous Gal-9 could be a potential therapeutic agent for COPD. PMID:28704475

  10. The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects.

    LENUS (Irish Health Repository)

    Lyng, F M

    2006-04-01

    Much evidence now exists regarding radiation-induced bystander effects, but the mechanisms involved in the transduction of the signal are still unclear. The mitogen-activated protein kinase (MAPK) pathways have been linked to growth factor-mediated regulation of cellular events such as proliferation, senescence, differentiation and apoptosis. Activation of multiple MAPK pathways such as the ERK, JNK and p38 pathways have been shown to occur after exposure of cells to radiation and a variety of other toxic stresses. Previous studies have shown oxidative stress and calcium signaling to be important in radiation-induced bystander effects. The aim of the present study was to investigate MAPK signaling pathways in bystander cells exposed to irradiated cell conditioned medium (ICCM) and the role of oxidative metabolism and calcium signaling in the induction of bystander responses. Human keratinocytes (HPV-G cell line) were irradiated (0.005-5 Gy) using a cobalt-60 teletherapy unit. The medium was harvested 1 h postirradiation and transferred to recipient HPV-G cells. Phosphorylated forms of p38, JNK and ERK were studied by immunofluorescence 30 min-24 h after exposure to ICCM. Inhibitors of the ERK pathway (PD98059 and U0126), the JNK pathway (SP600125), and the p38 pathway (SB203580) were used to investigate whether bystander-induced cell death could be blocked. Cells were also incubated with ICCM in the presence of superoxide dismutase, catalase, EGTA, verapamil, nifedipine and thapsigargin to investigate whether bystander effects could be inhibited because of the known effects on calcium homeostasis. Activated forms of JNK and ERK proteins were observed after exposure to ICCM. Inhibition of the ERK pathway appeared to increase bystander-induced apoptosis, while inhibition of the JNK pathway appeared to decrease apoptosis. In addition, reactive oxygen species, such as superoxide and hydrogen peroxide, and calcium signaling were found to be important modulators of

  11. Organisation of working time: Implications for productivity and working conditions. Overview Report

    OpenAIRE

    Goudswaard, A.; Dhondt, S.; Vergeer, R.; Oeij, P.; Leede, J. de; Adrichem, K. van C; Csizmadia, P.; Makó, C.; Illésy, M.; Tóth, A.

    2012-01-01

    Companies in search of improved productivity use a wide range of approaches, from financial incentives and skills upgrading and training to increased autonomy of individuals and teams. Working time flexibility has the added advantage in that it can benefit both workers and employers: it gives workers more control over their work–life balance and allows companies to adjust more easily to changing economic circumstances. Eurofound research studied five companies in manufacturing and retail in B...

  12. Relating lab to life: Decrements in attention over time predict math productivity among children with ADHD.

    Science.gov (United States)

    Fosco, Whitney D; Hawk, Larry W

    2017-02-01

    A child's ability to sustain attention over time (AOT) is critical in attention-deficit/hyperactivity disorder (ADHD), yet no prior work has examined the extent to which a child's decrement in AOT on laboratory tasks relates to clinically-relevant behavior. The goal of this study is to provide initial evidence for the criterion validity of laboratory assessments of AOT. A total of 20 children with ADHD (7-12 years of age) who were enrolled in a summer treatment program completed two lab attention tasks (a continuous performance task and a self-paced choice discrimination task) and math seatwork. Analyses focused on relations between attention task parameters and math productivity. Individual differences in overall attention (OA) measures (averaged across time) accounted for 23% of the variance in math productivity, supporting the criterion validity of lab measures of attention. The criterion validity was enhanced by consideration of changes in AOT. Performance on all laboratory attention measures deteriorated as time-on-task increased, and individual differences in the decrement in AOT accounted for 40% of the variance in math productivity. The only variable to uniquely predict math productivity was from the self-paced choice discrimination task. This study suggests that attention tasks in the lab do predict a clinically-relevant target behavior in children with ADHD, supporting their use as a means to study attention processes in a controlled environment. Furthermore, this prediction is improved when attention is examined as a function of time-on-task and when the attentional demands are consistent between lab and life contexts.

  13. Monitoring Volatile Organic Compounds (VOCs) in real-time on oil and natural gas production sites

    Science.gov (United States)

    Lupardus, R.; Franklin, S. B.

    2017-12-01

    Oil and Natural Gas (O&NG) development, production, infrastructure, and associated processing activities can be a substantial source of air pollution, yet relevant data and real-time quantification methods are lacking. In the current study, O&NG fugitive emissions of Volatile Organic Compounds (VOCs) were quantified in real-time and used to determine the spatial and temporal windows of exposure for proximate flora and fauna. Eleven O&NG sites on the Pawnee National Grassland in Northeastern Colorado were randomly selected and grouped according to production along with 13 control sites from three geographical locations. At each site, samples were collected 25 m from the wellhead in NE, SE, and W directions. In each direction, two samples were collected with a Gasmet DX4040 gas analyzer every hour from 8:00 am to 2:00 pm (6 hours total), July to October, 2016 (N=864). VOC concentrations generally increased during the 6 hr. day with the exception of N2O and were predominately the result of O&NG production and not vehicle exhaust. Thirteen of 24 VOCs had significantly different levels between production groups, frequently above reference standards and at biologically relevant levels for flora and fauna. The most biologically relevant VOCs, found at concentrations exceeding time weighted average permissible exposure limits (TWA PELs), were benzene and acrolein. Generalized Estimating Equations (GEEs) measured the relative quality of statistical models predicting benzene concentrations on sites. The data not only confirms that O&NG emissions are impacting the region, but also that this influence is present at all sites, including controls. Increased real-time VOC monitoring on O&NG sites is required to identify and contain fugitive emissions and to protect human and environmental health.

  14. Steps of Supercritical Fluid Extraction of Natural Products and Their Characteristic Times

    OpenAIRE

    Sovová, H. (Helena)

    2012-01-01

    Kinetics of supercritical fluid extraction (SFE) from plants is variable due to different micro-structure of plants and their parts, different properties of extracted substances and solvents, and different flow patterns in the extractor. Variety of published mathematical models for SFE of natural products corresponds to this diversification. This study presents simplified equations of extraction curves in terms of characteristic times of four single extraction steps: internal diffusion, exter...

  15. Clinical evaluation of marketed orthodontic products: are researchers behind the times? A meta-epidemiological study

    Directory of Open Access Journals (Sweden)

    Jadbinder Seehra

    2017-05-01

    Full Text Available Abstract Background The role of marketing and industry in the treatment decisions of orthodontists has received increasing attention in recent years with clinical research typically undertaken subsequent to established use of these devices and often failing to confirm the promise of manufacturers’ claims. This meta-epidemiological study was undertaken to assess the proportion of clinical trials in orthodontics evaluating commercially marketed products and to evaluate the direction of the results of these studies. Methods Electronic searching was undertaken to identify randomized controlled trials (RCTs published over a 5-year period (1 January 2012 to 31 December 2016. Data obtained included the type of marketed intervention, direction of effect and declaration of both industry sponsorship and conflict of interest. Results Eighty-four RCTs published in 23 scientific journals were included with the highest percentage in the American Journal of Dentofacial Orthopedics (AJO-DO (23.8%, followed by the European Journal of Orthodontics (EJO (14.3%, Journal of Orthodontics (JO (10.7% and Angle Orthodontist (AO (10.7%. Overall, 45% (38/84 of clinical trials assessed involved analysis of marketed products after their introduction. Interventions to improve oral health or circumvent the risk of iatrogenic damage, such as white spot lesions, were most commonly assessed (15.8%, with the relative merits of non-surgical adjuncts (14.1% and other orthodontic auxiliaries (13.1% also frequently evaluated. In 44% of RCTs, a positive effect of the marketed intervention was not reported. Industry sponsorship of the research was declared in 9.5% RCTs. No significant associations between the direction of the effect and both declaration of industry sponsorship (p = 0.56 and conflict of interest (p = 0.96 were detected. Moreover, for marketed and non-marketed products, no significant associations for both declaration of industry sponsorship (p = 0.44 and

  16. Petunia hybrida CAROTENOID CLEAVAGE DIOXYGENASE7 is involved in the production of negative and positive branching signals in petunia.

    Science.gov (United States)

    Drummond, Revel S M; Martínez-Sánchez, N Marcela; Janssen, Bart J; Templeton, Kerry R; Simons, Joanne L; Quinn, Brian D; Karunairetnam, Sakuntala; Snowden, Kimberley C

    2009-12-01

    One of the key factors that defines plant form is the regulation of when and where branches develop. The diversity of form observed in nature results, in part, from variation in the regulation of branching between species. Two CAROTENOID CLEAVAGE DIOXYGENASE (CCD) genes, CCD7 and CCD8, are required for the production of a branch-suppressing plant hormone. Here, we report that the decreased apical dominance3 (dad3) mutant of petunia (Petunia hybrida) results from the mutation of the PhCCD7 gene and has a less severe branching phenotype than mutation of PhCCD8 (dad1). An analysis of the expression of this gene in wild-type, mutant, and grafted petunia suggests that in petunia, CCD7 and CCD8 are coordinately regulated. In contrast to observations in Arabidopsis (Arabidopsis thaliana), ccd7ccd8 double mutants in petunia show an additive phenotype. An analysis using dad3 or dad1 mutant scions grafted to wild-type rootstocks showed that when these plants produce adventitious mutant roots, branching is increased above that seen in plants where the mutant roots are removed. The results presented here indicate that mutation of either CCD7 or CCD8 in petunia results in both the loss of an inhibitor of branching and an increase in a promoter of branching.

  17. Transcript Quantification of Genes Involved in Steviol Glycoside Biosynthesis in Stevia rebaudiana Bertoni by Real-Time Polymerase Chain Reaction (RT-PCR).

    Science.gov (United States)

    Modi, Arpan; Kumar, Nitish; Narayanan, Subhash

    2016-01-01

    Stevia (Stevia rebaudiana Bertoni) is a medicinal plant having sweet, diterpenoid glycosides known as steviol glycosides which are 200-300 times sweeter than sucrose (0.4 % solution). They are synthesized mainly in the leaves via plastid localized 2-C-methyl-D-erythrose-4-phosphate pathway (MEP pathway). Fifteen genes are involved in the formation of these glycosides. In the present protocol, a method for the quantification of transcripts of these genes is shown. The work involves RNA extraction and cDNA preparation, and therefore, procedures for the confirmation of DNA-free cDNA preparation have also been illustrated. Moreover, details of plant treatments are not mentioned as this protocol may apply to relative gene expression profile in any medicinal plant with any treatment. The treatments are numbered as T0 (Control), T1, T2, T3, and T4.

  18. An integrated production inventory model of deteriorating items subject to random machine breakdown with a stochastic repair time

    Directory of Open Access Journals (Sweden)

    Huynh Trung Luong

    2016-11-01

    Full Text Available In a continuous manufacturing environment where production and consumption occur simultaneously, one of the biggest challenges is the efficient management of production and inventory system. In order to manage the integrated production inventory system economically it is necessary to identify the optimal production time and the optimal production reorder point that either maximize the profit or minimize the cost. In addition, during production the process has to go through some natural phenomena like random breakdown of machine, deterioration of product over time, uncertainty in repair time that eventually create the possibility of shortage. In this situation, efficient management of inventory & production is crucial. This paper addresses the situation where a perishable (deteriorated product is manufactured and consumed simultaneously, the demand of this product is stable over the time, machine that produce the product also face random failure and the time to repair this machine is also uncertain. In order to describe this scenario more appropriately, the continuously reviewed Economic Production Quantity (EPQ model is considered in this research work. The main goal is to identify the optimal production uptime and the production reorder point that ultimately minimize the expected value of total cost consisting of machine setup, deterioration, inventory holding, shortage and corrective maintenance cost.

  19. Time-dependent radiolytic product concentrations in the water flow of a spinning wheel target

    International Nuclear Information System (INIS)

    Burns, W.G.; Goodall, J.A.B.

    1989-01-01

    Using the Harwell Facsimile computer simulation package, values of water radiolytic product concentrations, for both transient radicals and stable molecules were calculated for a single revolution of the cooling water at 75 0 C in a spallation neutron source target wheel irradiated with 1000 MeV protons and consequential secondary radiation. The radiation was pulsed except for part of the γ radiation, which was continuous. The stable product concentrations at first rose and eventually came to steady values before the end of the revolution. Comparison with results for steady radiation suggested that with the mixed radiation molecular products from the more densely ionizing radiation were largely destroyed by the radicals from the more lightly ionizing radiation. The distribution of the dose rate in time and space also tended to give a lower extent of radiolysis than calculated for uniform irradiation at the arithmetic mean dose rate. The effect of a second revolution on the diluted products showed a smaller increase in product concentrations than for the first revolution. The Authors consider that the extent of radiolysis should be manageable. (author)

  20. Influence of water activity, temperature and time on mycotoxins production on barley rootlets.

    Science.gov (United States)

    Ribeiro, J M M; Cavaglieri, L R; Fraga, M E; Direito, G M; Dalcero, A M; Rosa, C A R

    2006-02-01

    The objective of this study was to determine the ochratoxin (OT) and aflatoxin (AF) production by three strains of Aspergillus spp. under different water activities, temperature and incubation time on barley rootlets (BR). Aspergillus ochraceus and Aspergillus flavus were able to produce mycotoxins on BR. Aspergillus ochraceus produced ochratoxin A (OTA) at 0.80 water activity (a(w)), at 25 and 30 degrees C as optimal environmental conditions. The OTA production varies at different incubation days depending on a(w). Aflatoxin B(1) (AFB1) accumulation was obtained at 25 degrees C, at 0.80 and 0.95 a(w), after 14 and 21 incubation days respectively. Temperature was a critical factor influencing OTA and AFB(1) production. This study demonstrates that BR support OTA and AFB(1) production at relatively low water activity (0.80 a(w)) and high temperatures (25-30 degrees C). The study of ecophysiological parameters and their interactions would determine the prevailing environmental factors, which enhance the mycotoxin production on BR used as animal feed.

  1. A Time Series Analysis of Global Soil Moisture Data Products for Water Cycle Studies

    Science.gov (United States)

    Zhan, X.; Yin, J.; Liu, J.; Fang, L.; Hain, C.; Ferraro, R. R.; Weng, F.

    2017-12-01

    Water is essential for sustaining life on our planet Earth and water cycle is one of the most important processes of out weather and climate system. As one of the major components of the water cycle, soil moisture impacts significantly the other water cycle components (e.g. evapotranspiration, runoff, etc) and the carbon cycle (e.g. plant/crop photosynthesis and respiration). Understanding of soil moisture status and dynamics is crucial for monitoring and predicting the weather, climate, hydrology and ecological processes. Satellite remote sensing has been used for soil moisture observation since the launch of the Scanning Multi-channel Microwave Radiometer (SMMR) on NASA's Nimbus-7 satellite in 1978. Many satellite soil moisture data products have been made available to the science communities and general public. The soil moisture operational product system (SMOPS) of NOAA NESDIS has been operationally providing global soil moisture data products from each of the currently available microwave satellite sensors and their blends. This presentation will provide an update of SMOPS products. The time series of each of these soil moisture data products are analyzed against other data products, such as precipitation and evapotranspiration from other independent data sources such as the North America Land Data Assimilation System (NLDAS). Temporal characteristics of these water cycle components are explored against some historical events, such as the 2010 Russian, 2010 China and 2012 United States droughts, 2015 South Carolina floods, etc. Finally whether a merged global soil moisture data product can be used as a climate data record is evaluated based on the above analyses.

  2. Cycle Time Optimization of Chamomile Package 120 MI Product at Blow Molding Process

    Directory of Open Access Journals (Sweden)

    Yuni Hermawan

    2012-11-01

    Full Text Available Chamomile is a package which is applied for cosmetic. In industry this package is being processed by blow molding. Thereare many parameters that influence cycle time during production; in this project only three of them were varied, i.e. blowingpressure, blowing time and stopping time. Each parameter is determined three chosen level. Middle level is taken fromstandard setting of machining which is being used by industry. Top and bottom level is randomized. Three stopping time are0.1, 0.55, and 1.0 second. Blowing time are 10.5, 11.5 and 12.5 second. Where as, blowing pressures is 4, 5 and 6 bar.Combination of among levels is based on Box Behnken design. Those three parameters are called variable process. In theother hand, variable responses are cycle time and net weight. Each combination is replicated 5 times and then averaged. Thedata then is processed by using Minitab version 14th. Square regression of the model for cycle time is ?CT = 21,1300 - 0,0912X1 + 0,2000 X2 + 0,6313 X3 + 0,6100 X12 + 0,6975 X22 – 0,1000 X1 X2 – 0,1725 X1 X3 + 0,1100 X2 X3 and Net = 19,2933 –0,0088 X1 + 0,0175 X2 + 0,0712 X3 + 0,0133 X 21 + 0.0158 X22- 0.0217 X 23 + 0.0125 X1X2 - 0,0150 X1 X3 for product netweight. Where X1 is blowing pressure, X2 is blowing time and X3 is stopping time.The model developed then tested by lack offit testing, variance by ANOVA and R square. Second stage of model testing is residual test. Three tests are carry out, i.e.identically test and independency test and normality. Optimization of both values, cycle time and net weight, are searched byResponse Surface Method. By the method it is found that the optimum condition of cycle time is 20.5 seconds and net weightis 19.19 grams. The optimum condition is achieved when stopping is 0.1 second, blowing time 11.35 second and blowingpressure 5.1 bars.

  3. Productivity

    DEFF Research Database (Denmark)

    Spring, Martin; Johnes, Geraint; Hald, Kim Sundtoft

    Productivity is increasingly critical for developed economies. It has always been important: as Paul Krugman puts it, “Productivity isn’t everything, but in the long run it is almost everything. A country’s ability to improve its standard of living over time depends almost entirely on its ability...... to raise its output per worker”(Krugman, 1994). Analyses of productivity have, by and large, been the preserve of economists. Operations Management (OM) is rooted in a similar concern for the efficient use of scarce resources; Management Accounting (MA) is concerned with the institutionalised measurement...... and management of productivity. Yet the three perspectives are rarely connected. This paper is a sketch of a literature review seeking to identify, contrast and reconcile these three perspectives. In so doing, it aims to strengthen the connections between policy and managerial analyses of productivity....

  4. Improved α-amylase production by Aspergillus oryzae after a double deletion of genes involved in carbon catabolite repression.

    Science.gov (United States)

    Ichinose, Sakurako; Tanaka, Mizuki; Shintani, Takahiro; Gomi, Katsuya

    2014-01-01

    In filamentous fungi, the expression of secretory glycoside hydrolase encoding genes, such as those for amylases, cellulases, and xylanases, is generally repressed in the presence of glucose. CreA and CreB have been observed to be regulating factors for carbon catabolite repression. In this study, we generated single and double deletion creA and/or creB mutants in Aspergillus oryzae. The α-amylase activities of each strain were compared under various culture conditions. For the wild-type strain, mRNA levels of α-amylase were markedly decreased in the later stage of submerged culture under inducing conditions, whereas this reduced expression was not observed for single creA and double creA/creB deletion mutants. In addition, α-amylase activity of the wild-type strain was reduced in submerged culture containing high concentrations of inducing sugars, whereas all constructed mutants showed higher α-amylase activities. In particular, the α-amylase activity of the double deletion mutant in a medium containing 5% starch was >10-fold higher than that of the wild-type strain under the same culture conditions. In solid-state cultures using wheat bran as a substrate, the α-amylase activities of single creA and double deletion mutants were >2-fold higher than that of the wild-type strain. These results suggested that deleting both creA and creB resulted in dramatic improvements in the production of secretory glycoside hydrolases in filamentous fungi.

  5. Updating Landsat time series of surface-reflectance composites and forest change products with new observations

    Science.gov (United States)

    Hermosilla, Txomin; Wulder, Michael A.; White, Joanne C.; Coops, Nicholas C.; Hobart, Geordie W.

    2017-12-01

    The use of time series satellite data allows for the temporally dense, systematic, transparent, and synoptic capture of land dynamics over time. Subsequent to the opening of the Landsat archive, several time series approaches for characterizing landscape change have been developed, often representing a particular analytical time window. The information richness and widespread utility of these time series data have created a need to maintain the currency of time series information via the addition of new data, as it becomes available. When an existing time series is temporally extended, it is critical that previously generated change information remains consistent, thereby not altering reported change statistics or science outcomes based on that change information. In this research, we investigate the impacts and implications of adding additional years to an existing 29-year annual Landsat time series for forest change. To do so, we undertook a spatially explicit comparison of the 29 overlapping years of a time series representing 1984-2012, with a time series representing 1984-2016. Surface reflectance values, and presence, year, and type of change were compared. We found that the addition of years to extend the time series had minimal effect on the annual surface reflectance composites, with slight band-specific differences (r ≥ 0.1) in the final years of the original time series being updated. The area of stand replacing disturbances and determination of change year are virtually unchanged for the overlapping period between the two time-series products. Over the overlapping temporal period (1984-2012), the total area of change differs by 0.53%, equating to an annual difference in change area of 0.019%. Overall, the spatial and temporal agreement of the changes detected by both time series was 96%. Further, our findings suggest that the entire pre-existing historic time series does not need to be re-processed during the update process. Critically, given the time

  6. Global, real-time ionosphere specification for end-user communication and navigation products

    Science.gov (United States)

    Tobiska, W.; Carlson, H. C.; Schunk, R. W.; Thompson, D. C.; Sojka, J. J.; Scherliess, L.; Zhu, L.; Gardner, L. C.

    2010-12-01

    Space weather’s effects upon the near-Earth environment are due to dynamic changes in the energy transfer processes from the Sun’s photons, particles, and fields. Of the space environment domains that are affected by space weather, the ionosphere is the key region that affects communication and navigation systems. The Utah State University (USU) Space Weather Center (SWC) is a developer and producer of commercial space weather applications. A key system-level component for providing timely information about the effects of space weather is the Global Assimilation of Ionospheric Measurements (GAIM) system. GAIM, operated by SWC, improves real-time communication and navigation systems by continuously ingesting up to 10,000 slant TEC measurements every 15-minutes from approximately 500 stations. Using a Kalman filter, the background output from the physics-based Ionosphere Forecast Model (IFM) is adjusted to more accurately represent the actual ionosphere. An improved ionosphere leads to more useful derivative products. For example, SWC runs operational code, using GAIM, to calculate and report the global radio high frequency (HF) signal strengths for 24 world cities. This product is updated every 15 minutes at http://spaceweather.usu.edu and used by amateur radio operators. SWC also developed and provides through Apple iTunes the widely used real-time space weather iPhone app called SpaceWx for public space weather education. SpaceWx displays the real-time solar, heliosphere, magnetosphere, thermosphere, and ionosphere drivers to changes in the total electron content, for example. This smart phone app is tip of the “iceberg” of automated systems that provide space weather data; it permits instant understanding of the environment surrounding Earth as it dynamically changes. SpaceWx depends upon a distributed network that connects satellite and ground-based data streams with algorithms to quickly process the measurements into geophysical data, incorporate those

  7. LAI, FAPAR and FCOVER products derived from AVHRR long time series: principles and evaluation

    Science.gov (United States)

    Verger, A.; Baret, F.; Weiss, M.; Lacaze, R.; Makhmara, H.; Pacholczyk, P.; Smets, B.; Kandasamy, S.; Vermote, E.

    2012-04-01

    Continuous and long term global monitoring of the terrestrial biosphere has draught an intense interest in the recent years in the context of climate and global change. Developing methodologies for generating historical data records from data collected with different satellite sensors over the past three decades by taking benefits from the improvements identified in the processing of the new generation sensors is a new central issue in remote sensing community. In this context, the Bio-geophysical Parameters (BioPar) service within Geoland2 project (http://www.geoland2.eu) aims at developing pre-operational infrastructures for providing global land products both in near real time and off-line mode with long time series. In this contribution, we describe the principles of the GEOLAND algorithm for generating long term datasets of three key biophysical variables, leaf area index (LAI), Fraction of Absorbed Photosynthetic Active Radiation (FAPAR) and cover fraction (FCOVER), that play a key role in several processes, including photosynthesis, respiration and transpiration. LAI, FAPAR and FCOVER are produced globally from AVHRR Long Term Data Record (LTDR) for the 1981-2000 period at 0.05° spatial resolution and 10 days temporal sampling frequency. The proposed algorithm aims to ensure robustness of the derived long time series and consistency with the ones developed in the recent years, and particularly with GEOLAND products derived from VEGETATION sensor. The approach is based on the capacity of neural networks to learn a particular biophysical product (GEOLAND) from reflectances from another sensor (AVHRR normalized reflectances in the red and near infrared bands). Outliers due to possible cloud contamination or residual atmospheric correction are iteratively eliminated. Prior information based on the climatology is used to get more robust estimates. A specific gap filing and smoothing procedure was applied to generate continuous and smooth time series of decadal

  8. Computations of concentration of radon and its decay products against time. Computer program; Obliczanie koncentracji radonu i jego produktow rozpadu w funkcji czasu. Program komputerowy

    Energy Technology Data Exchange (ETDEWEB)

    Machaj, B. [Institute of Nuclear Chemistry and Technology, Warsaw (Poland)

    1996-12-31

    This research is aimed to develop a device for continuous monitoring of radon in the air, by measuring alpha activity of radon and its short lived decay products. The influence of alpha activity variation of radon and its daughters on the measured results is of importance and requires a knowledge of this variation with time. Employing the measurement of alpha radiation of radon and of its short lived decay products, require knowledge of radon concentration variation and its decay products against the time. A computer program in Turbo Pascal language was therefore developed performing the computations employing the known relations involved, the program being adapted for IBM PC computers. The presented program enables computation of activity of {sup 222}Rn and its daughter products: {sup 218}Po, {sup 214}Pb, {sup 214}Bi and {sup 214}Po every 1 min within the period of 0-255 min for any state of radiation equilibrium between the radon and its daughter products. The program permits also to compute alpha activity of {sup 222}Rn + {sup 218}Po + {sup 214}Po against time and the total alpha activity at selected interval of time. The results of computations are stored on the computer hard disk in ASCII format and are used a graphic program e.g. by DrawPerfect program to make diagrams. Equations employed for computation of the alpha activity of radon and its decay products as well as the description of program functions are given. (author). 2 refs, 4 figs.

  9. Molecular mechanisms involved in the production of chromosomal aberrations. I. Utilization of Neurospora endonuclease for the study of aberration production in G2 stage of the cell cycle

    Energy Technology Data Exchange (ETDEWEB)

    Natarajan, A T; Obe, G [Rijksuniversiteit Leiden (Netherlands). J.A. Cohen Inst. voor Radiopathologie en Stralingsbescherming

    1978-10-01

    Chinese hamster ovary cells (CHO) were X-irradiated in G2 stage of the cell cycle and immediately treated, in the presence of inactivated Sendai virus, with Neurospora endonuclease (E.C. 3.1.4.), an enzyme which is specific for cleaving single-stranded DNA. With this treatment, the frequencies of all types of chromosome aberrations increased when compared to X-irradiated controls. These results are interpreted as due to the conversion of some of the X-ray induced single-stranded DNA breaks into double-strand breaks by this enzyme. Similar enhancement due to this enzyme was found following treatment with methyl methanesulfonate (MMS) and bleomycin, but not following UV and mitomycin C. Addition of Micrococcus endonuclease and Neurospora endonuclease to the cells did not alter the frequencies of aberrations induced by UV. The introduction of enzymes with specific DNA-repair function offers possibilities to probe into the molecular events involved in the formation of structural chromosome aberrations induced by different classes of physical and chemical mutagens.

  10. Functional characterization of a three-component regulatory system involved in quorum sensing-based regulation of peptide antibiotic production in Carnobacterium maltaromaticum

    Directory of Open Access Journals (Sweden)

    Quadri Luis EN

    2006-10-01

    Full Text Available Abstract Background Quorum sensing is a form of cell-to-cell communication that allows bacteria to control a wide range of physiological processes in a population density-dependent manner. Production of peptide antibiotics is one of the processes regulated by quorum sensing in several species of Gram-positive bacteria, including strains of Carnobacterium maltaromaticum. This bacterium and its peptide antibiotics are of interest due to their potential applications in food preservation. The molecular bases of the quorum sensing phenomenon controlling peptide antibiotic production in C. maltaromaticum remain poorly understood. The present study was aimed at gaining a deeper insight into the molecular mechanism involved in quorum sensing-mediated regulation of peptide antibiotic (bacteriocin production by C. maltaromaticum. We report the functional analyses of the CS (autoinducer-CbnK (histidine protein kinase-CbnR (response regulator three-component regulatory system and the three regulated promoters involved in peptide antibiotic production in C. maltaromaticum LV17B. Results CS-CbnK-CbnR system-dependent activation of carnobacterial promoters was demonstrated in both homologous and heterologous hosts using a two-plasmid system with a β-glucuronidase (GusA reporter read-out. The results of our analyses support a model in which the CbnK-CbnR two-component signal transduction system is necessary and sufficient to transduce the signal of the peptide autoinducer CS into the activation of the promoters that drive the expression of the genes required for production of the carnobacterial peptide antibiotics and the immunity proteins that protect the producer bacterium. Conclusions The CS-CbnK-CbnR triad forms a three-component regulatory system by which production of peptide antibiotics by C. maltaromaticum LV17B is controlled in a population density-dependent (or cell proximity-dependent manner. This regulatory mechanism would permit the bacterial

  11. The diagnosis of microorganism involved in infective endocarditis (IE by polymerase chain reaction (PCR and real-time PCR: A systematic review

    Directory of Open Access Journals (Sweden)

    Reza Faraji

    2018-02-01

    Full Text Available Broad-range bacterial rDNA polymerase chain reaction (PCR followed by sequencing may be identified as the etiology of infective endocarditis (IE from surgically removed valve tissue; therefore, we reviewed the value of molecular testing in identifying organisms' DNA in the studies conducted until 2016. We searched Google Scholar, Scopus, ScienceDirect, Cochrane, PubMed, and Medline electronic databases without any time limitations up to December 2016 for English studies reporting microorganisms involved in infective endocarditis microbiology using PCR and real-time PCR. Most studies were prospective. Eleven out of 12 studies used valve tissue samples and blood cultures while only 1 study used whole blood. Also, 10 studies used the molecular method of PCR while 2 studies used real-time PCR. Most studies used 16S rDNA gene as the target gene. The bacteria were identified as the most common microorganisms involved in infective endocarditis. Streptococcus spp. and Staphylococcus spp. were, by far, the most predominant bacteria detected. In all studies, PCR and real-time PCR identified more pathogens than blood and tissue cultures; moreover, the sensitivity and specificity of PCR and real-time PCR were more than cultures in most of the studies. The highest sensitivity and specificity were 96% and 100%, respectively. The gram positive bacteria were the most frequent cause of infective endocarditis. The molecular methods enjoy a greater sensitivity compared to the conventional blood culture methods; yet, they are applicable only to the valve tissue of the patients undergoing cardiac valve surgery.

  12. The diagnosis of microorganism involved in infective endocarditis (IE) by polymerase chain reaction (PCR) and real-time PCR: A systematic review.

    Science.gov (United States)

    Faraji, Reza; Behjati-Ardakani, Mostafa; Moshtaghioun, Seyed Mohammad; Kalantar, Seyed Mehdi; Namayandeh, Seyedeh Mahdieh; Soltani, Mohammadhossien; Emami, Mahmood; Zandi, Hengameh; Firoozabadi, Ali Dehghani; Kazeminasab, Mahmood; Ahmadi, Nastaran; Sarebanhassanabadi, Mohammadtaghi

    2018-02-01

    Broad-range bacterial rDNA polymerase chain reaction (PCR) followed by sequencing may be identified as the etiology of infective endocarditis (IE) from surgically removed valve tissue; therefore, we reviewed the value of molecular testing in identifying organisms' DNA in the studies conducted until 2016. We searched Google Scholar, Scopus, ScienceDirect, Cochrane, PubMed, and Medline electronic databases without any time limitations up to December 2016 for English studies reporting microorganisms involved in infective endocarditis microbiology using PCR and real-time PCR. Most studies were prospective. Eleven out of 12 studies used valve tissue samples and blood cultures while only 1 study used whole blood. Also, 10 studies used the molecular method of PCR while 2 studies used real-time PCR. Most studies used 16S rDNA gene as the target gene. The bacteria were identified as the most common microorganisms involved in infective endocarditis. Streptococcus spp. and Staphylococcus spp. were, by far, the most predominant bacteria detected. In all studies, PCR and real-time PCR identified more pathogens than blood and tissue cultures; moreover, the sensitivity and specificity of PCR and real-time PCR were more than cultures in most of the studies. The highest sensitivity and specificity were 96% and 100%, respectively. The gram positive bacteria were the most frequent cause of infective endocarditis. The molecular methods enjoy a greater sensitivity compared to the conventional blood culture methods; yet, they are applicable only to the valve tissue of the patients undergoing cardiac valve surgery. Copyright © 2017. Published by Elsevier Taiwan.

  13. Coproduct and star product in field theories on Lie-algebra noncommutative space-times

    International Nuclear Information System (INIS)

    Amelino-Camelia, Giovanni; Arzano, Michele

    2002-01-01

    We propose a new approach to field theory on κ-Minkowski noncommutative space-time, a popular example of Lie-algebra space-time. Our proposal is essentially based on the introduction of a star product, a technique which is proving to be very fruitful in analogous studies of canonical noncommutative space-times, such as the ones recently found to play a role in the description of certain string-theory backgrounds. We find to be incorrect the expectation, previously reported in the literature, that the lack of symmetry of the κ-Poincare coproduct should lead to interaction vertices that are not symmetric under exchanges of the momenta of identical particles entering the relevant processes. We show that in κ-Minkowski the coproduct and the star product must indeed treat momenta in a nonsymmetric way, but the overall structure of interaction vertices is symmetric under exchange of identical particles. We also show that in κ-Minkowski field theories it is convenient to introduce the concepts of 'planar' and 'nonplanar' Feynman loop diagrams, again in close analogy with the corresponding concepts previously introduced in the study of field theories in canonical noncommutative space-times

  14. Time and temperature dependence of cascade induced defect production in in situ experiments and computer simulation

    International Nuclear Information System (INIS)

    Ishino, Shiori

    1993-01-01

    Understanding of the defect production and annihilation processes in a cascade is important in modelling of radiation damage for establishing irradiation correlation. In situ observation of heavy ion radiation damage has a great prospect in this respect. Time and temperature dependence of formation and annihilation of vacancy clusters in a cascade with a time resolution of 30 ms has been studied with a facility which comprises a heavy ion accelerator and an electron microscope. Formation and annihilation rates of defect clusters have been separately measured by this technique. The observed processes have been analysed by simple kinetic equations, taking into account the sink effect of surface and the defect clusters themselves together with the annihilation process due to thermal emission of vacancies from the defect clusters. Another tool to study time and temperature dependence of defect production in a cascade is computer simulation. Recent results of molecular dynamics calculations on the temperature dependence of cascade evolution are presented, including directional and temperature dependence of the lengths of replacement collision sequences, temperature dependence of the process to reach thermal equilibrium and so on. These results are discussed under general time frame of radiation damage evolution covering from 10 -15 to 10 9 s, and several important issues for the general understanding have been identified. (orig.)

  15. New products from the power merchant to customer with time measurements and load management

    International Nuclear Information System (INIS)

    Solem, Gerd; Doorman, Gerard; Grande, Ove S.

    2003-01-01

    The main aim is to develop products from the power merchants that improve the consumer flexibility. For the development of the products the basis is that the consumption is measured by hours and that a connection to a load management scheme is present. Calculations for four products are made where the risk exposure is different for the customer and the supplier. The four products are ''Spot price with mark-up'', ''The combination of constant price and spot price'', ''Constant price with disconnection'' and ''Effect subscription''. The customers are exposed to the spot price in the first two products and may through disconnection reduce the costs by adapting to the market signals. Remote disconnection of parts of the consumption may be offered as a service jointly by the network companies and the power suppliers through a two-way communication but it is not realistic that the customers may pay much for this. ''Spot price with mark-up'' implies that the customer carries the entire risk while constant price may place considerable risk at the power supplier by long high consumption combined with high spot prices. '' Constant price with disconnection'' gives the power supplier the possibilities of reducing the risks. A disconnection possibility that is committing to the customers may be part of the product specification. The customers may be offered a discount calculated out from the costs for alternative price securing. Also '' Effect subscription'' reduces the merchant risks considerably at the disconnection of the consumption. The ''combined product of constant and spot price'' may be interesting from the supplier's viewpoint due to considerable risk reductions compared to solely using the constant price. The product gives the customers a guaranteed price for a part of the product and has an additional possibility of adapting the consumption to the market signals. The network company routines for handling of the hour values are a large challenge. It is important to

  16. Time-invariant PT product and phase locking in PT -symmetric lattice models

    Science.gov (United States)

    Joglekar, Yogesh N.; Onanga, Franck Assogba; Harter, Andrew K.

    2018-01-01

    Over the past decade, non-Hermitian, PT -symmetric Hamiltonians have been investigated as candidates for both a fundamental, unitary, quantum theory and open systems with a nonunitary time evolution. In this paper, we investigate the implications of the former approach in the context of the latter. Motivated by the invariance of the PT (inner) product under time evolution, we discuss the dynamics of wave-function phases in a wide range of PT -symmetric lattice models. In particular, we numerically show that, starting with a random initial state, a universal, gain-site location dependent locking between wave-function phases at adjacent sites occurs in the PT -symmetry-broken region. Our results pave the way towards understanding the physically observable implications of time invariants in the nonunitary dynamics produced by PT -symmetric Hamiltonians.

  17. Optimal batch production strategies under continuous price decrease and time discounting

    Directory of Open Access Journals (Sweden)

    Mandal S.

    2007-01-01

    Full Text Available Single price discount in unit cost for bulk purchasing is quite common in reality as well as in inventory literature. However, in today's high-tech industries such as personal computers and mobile industries, continuous decrease in unit cost is a regular phenomenon. In the present paper, an attempt has been made to investigate the effects of continuous price decrease and time-value of money on optimal decisions for inventoried goods having time-dependent demand and production rates. The proposed models are developed over a finite time horizon considering both shortages and without shortages in inventory. Numerical examples are taken to illustrate the developed models and to examine the sensitivity of model parameters.

  18. Creation and clinical application of real-time dose monitor using dose area product meter

    International Nuclear Information System (INIS)

    Matsubara, Kosuke; Uoyama, Yoshinori; Iida, Hiroji; Mizushima, Takashi

    2004-01-01

    The management of patient dose has become more of an issue in recent years. Dose can be determined non-invasively and in real time through the use of a dose area product meter, but it is the area dose value that is obtained. Therefore, we created a program that estimates entrance skin dose (ESD) in real time from area dose values obtained during procedures. We used Microsoft Visual C++ 6.0 (Standard Edition) for the programming language and C language for the programming environment. The value was a maximum 285.4 mGy at ileus tube insertion when measuring ESD for radiography of the digestive organ and non-vascular type interventional radiology (IVR) using the created program and seeking the average according to the procedures. The program that we created can be considered valid for monitoring ESD correctly and in real time. (author)

  19. Global Near Real-Time Satellite-based Flood Monitoring and Product Dissemination

    Science.gov (United States)

    Smith, M.; Slayback, D. A.; Policelli, F.; Brakenridge, G. R.; Tokay, M.

    2012-12-01

    Flooding is among the most destructive, frequent, and costly natural disasters faced by modern society, with several major events occurring each year. In the past few years, major floods have devastated parts of China, Thailand, Pakistan, Australia, and the Philippines, among others. The toll of these events, in financial costs, displacement of individuals, and deaths, is substantial and continues to rise as climate change generates more extreme weather events. When these events do occur, the disaster management community requires frequently updated and easily accessible information to better understand the extent of flooding and better coordinate response efforts. With funding from NASA's Applied Sciences program, we have developed, and are now operating, a near real-time global flood mapping system to help provide critical flood extent information within 24-48 hours after flooding events. The system applies a water detection algorithm to MODIS imagery received from the LANCE (Land Atmosphere Near real-time Capability for EOS) system at NASA Goddard. The LANCE system typically processes imagery in less than 3 hours after satellite overpass, and our flood mapping system can output flood products within ½ hour of acquiring the LANCE products. Using imagery from both the Terra (10:30 AM local time overpass) and Aqua (1:30 PM) platforms allows an initial assessment of flooding extent by late afternoon, every day, and more robust assessments after accumulating imagery over a longer period; the MODIS sensors are optical, so cloud cover remains an issue, which is partly overcome by using multiple looks over one or more days. Other issues include the relatively coarse scale of the MODIS imagery (250 meters), the difficulty of detecting flood waters in areas with continuous canopy cover, confusion of shadow (cloud or terrain) with water, and accurately identifying detected water as flood as opposed to normal water extents. We have made progress on some of these issues

  20. SMOS near-real-time soil moisture product: processor overview and first validation results

    Science.gov (United States)

    Rodríguez-Fernández, Nemesio J.; Muñoz Sabater, Joaquin; Richaume, Philippe; de Rosnay, Patricia; Kerr, Yann H.; Albergel, Clement; Drusch, Matthias; Mecklenburg, Susanne

    2017-10-01

    Measurements of the surface soil moisture (SM) content are important for a wide range of applications. Among them, operational hydrology and numerical weather prediction, for instance, need SM information in near-real-time (NRT), typically not later than 3 h after sensing. The European Space Agency (ESA) Soil Moisture and Ocean Salinity (SMOS) satellite is the first mission specifically designed to measure SM from space. The ESA Level 2 SM retrieval algorithm is based on a detailed geophysical modelling and cannot provide SM in NRT. This paper presents the new ESA SMOS NRT SM product. It uses a neural network (NN) to provide SM in NRT. The NN inputs are SMOS brightness temperatures for horizontal and vertical polarizations and incidence angles from 30 to 45°. In addition, the NN uses surface soil temperature from the European Centre for Medium-Range Weather Forecasts (ECMWF) Integrated Forecast System (IFS). The NN was trained on SMOS Level 2 (L2) SM. The swath of the NRT SM retrieval is somewhat narrower (˜ 915 km) than that of the L2 SM dataset (˜ 1150 km), which implies a slightly lower revisit time. The new SMOS NRT SM product was compared to the SMOS Level 2 SM product. The NRT SM data show a standard deviation of the difference with respect to the L2 data of Organisation for the Exploitation of Meteorological Satellites (EUMETSAT) multicast service (EUMETCast).

  1. Mathematical supply-chain modelling: Product analysis of cost and time

    International Nuclear Information System (INIS)

    Easters, D J

    2014-01-01

    Establishing a mathematical supply-chain model is a proposition that has received attention due to its inherent benefits of evolving global supply-chain efficiencies. This paper discusses the prevailing relationships found within apparel supply-chain environments, and contemplates the complex issues indicated for constituting a mathematical model. Principal results identified within the data suggest, that the multifarious nature of global supply-chain activities require a degree of simplification in order to fully dilate the necessary factors which affect, each sub-section of the chain. Subsequently, the research findings allowed the division of supply-chain components into sub-sections, which amassed a coherent method of product development activity. Concurrently, the supply-chain model was found to allow systematic mathematical formulae analysis, of cost and time, within the multiple contexts of each subsection encountered. The paper indicates the supply-chain model structure, the mathematics, and considers how product analysis of cost and time can improve the comprehension of product lifecycle management

  2. Relative planting times on the production components in sesame/cowpea bean intercropping in organic system

    Directory of Open Access Journals (Sweden)

    Afrânio César de Araújo

    2013-12-01

    Full Text Available Aiming at better land use, small farmers usually plant sesame and cowpea bean intercropped with other crops. The aim of this work was to analyze and quantify the influence of four relative planting times of the cowpea bean in intercropping with sesame from the standpoint of their production components, plant productivity and the index of land equivalent ratio (LER. The field experiment was conducted in a randomized blocks with four treatments and four replicates. The treatments were the sesame and the cowpea bean in intercropping with the cowpea bean planted at the same time, 7, 14 and 21days after than the sesame. A greater part of the production components of both the sesame as well the cowpea bean was affected by the intercropping and significant differences were noted among the treatments in a larger part of the parameters. As the planting of the cowpea bean became more distant from that of the sesame, the yield of the Pedaliaceae increased and the yield of the Fabaceae decreased. The results for LER findings on the other hand suggest that in the sesame/cowpea bean intercropping, when the Fabaceae is planted seven days after the sesame, there is better use of the land and a largest possibility to the producer earning a profit.

  3. Mathematical supply-chain modelling: Product analysis of cost and time

    Science.gov (United States)

    Easters, D. J.

    2014-03-01

    Establishing a mathematical supply-chain model is a proposition that has received attention due to its inherent benefits of evolving global supply-chain efficiencies. This paper discusses the prevailing relationships found within apparel supply-chain environments, and contemplates the complex issues indicated for constituting a mathematical model. Principal results identified within the data suggest, that the multifarious nature of global supply-chain activities require a degree of simplification in order to fully dilate the necessary factors which affect, each sub-section of the chain. Subsequently, the research findings allowed the division of supply-chain components into sub-sections, which amassed a coherent method of product development activity. Concurrently, the supply-chain model was found to allow systematic mathematical formulae analysis, of cost and time, within the multiple contexts of each subsection encountered. The paper indicates the supply-chain model structure, the mathematics, and considers how product analysis of cost and time can improve the comprehension of product lifecycle management.

  4. Paralinguistic mechanisms of production in human "beatboxing": a real-time magnetic resonance imaging study.

    Science.gov (United States)

    Proctor, Michael; Bresch, Erik; Byrd, Dani; Nayak, Krishna; Narayanan, Shrikanth

    2013-02-01

    Real-time magnetic resonance imaging (rtMRI) was used to examine mechanisms of sound production by an American male beatbox artist. rtMRI was found to be a useful modality with which to study this form of sound production, providing a global dynamic view of the midsagittal vocal tract at frame rates sufficient to observe the movement and coordination of critical articulators. The subject's repertoire included percussion elements generated using a wide range of articulatory and airstream mechanisms. Many of the same mechanisms observed in human speech production were exploited for musical effect, including patterns of articulation that do not occur in the phonologies of the artist's native languages: ejectives and clicks. The data offer insights into the paralinguistic use of phonetic primitives and the ways in which they are coordinated in this style of musical performance. A unified formalism for describing both musical and phonetic dimensions of human vocal percussion performance is proposed. Audio and video data illustrating production and orchestration of beatboxing sound effects are provided in a companion annotated corpus.

  5. Time-bound product returns and optimal order quantities for mass merchandisers

    Science.gov (United States)

    Yu, Min-Chun; Goh, Mark

    2012-01-01

    The return guidelines for a mass merchandiser usually entail a grace period, a markdown on the original price and the condition of the returned items. This research utilises eight scenarios formed from the variation of possible return guidelines to model the cost functions of single-product categories for a typical mass merchandiser. Models for the eight scenarios are developed and solved with the objective of maximising the expected profit so as to obtain closed form solutions for the associated optimal order quantity. An illustrative example and sensitivity analysis are provided to demonstrate the applicability of the model. Our results show that merchandisers who allow for returns within a time window, albeit with a penalty cost imposed and the returned products being recoverable, should plan for larger order amounts as such products do not affect the business. Similarly, the merchandisers who allow for returns beyond a grace period and without any penalty charges, but where the returned products are irrecoverable, should manage their stocks in this category more judiciously by ordering as little as possible so as to limit the number of returns and carefully consider the effects of their customer satisfaction-guaranteed policies, if any.

  6. Simulation model for improved production planning and control through quality, cycle time and batch size management

    Directory of Open Access Journals (Sweden)

    Kotevski Živko

    2015-01-01

    Full Text Available Production planning and control (PPC systems are the base of all production facilities. In today's surroundings, having a good PPC system generates lots of benefits for the companies. But, having an excellent PPC system provides great competitive advantage and serious reduction of cost in many fields. In order to get to a point of having excellent PPC, the companies turn more and more to the newest software tools, for simulations as an example. Considering today's advanced computer technology, by using the simulations in this area, companies will have strong asset when dealing with different kinds of wastes, delays, overstock, bottlenecks and generally loss of time. This model is applicable in almost all production facilities. Taking into account the different scrap percentages for the pieces that form the end product, a detailed model and analysis were made in order to determine the optimal starting parameters. At first all the conditions of the company were determined, conceptual model was created along with all assumptions. Then the model was verified and validated and at the end a cost benefit analysis was conducted in order to have clear results.

  7. NASA Langley Atmospheric Science Data Centers Near Real-Time Data Products

    Science.gov (United States)

    Davenport, T.; Parker, L.; Rinsland, P. L.

    2014-12-01

    Over the past decade the Atmospheric Science Data Center (ASDC) at NASA Langley Research Center has archived and distributed a variety of satellite mission data sets. NASA's goal in Earth science is to observe, understand, and model the Earth system to discover how it is changing, to better predict change, and to understand the consequences for life on Earth. The ASDC has collaborated with Science Teams to accommodate emerging science users in the climate and modeling communities. The ASDC has expanded its original role to support operational usage by related Earth Science satellites, support land and ocean assimilations, support of field campaigns, outreach programs, and application projects for agriculture and energy industries to bridge the gap between Earth science research results and the adoption of data and prediction capabilities for reliable and sustained use in Decision Support Systems (DSS). For example; these products are being used by the community performing data assimilations to regulate aerosol mass in global transport models to improve model response and forecast accuracy, to assess the performance of components of a global coupled atmospheric-ocean climate model, improve atmospheric motion vector (winds) impact on numerical weather prediction models, and to provide internet-based access to parameters specifically tailored to assist in the design of solar and wind powered renewable energy systems. These more focused applications often require Near Real-Time (NRT) products. Generating NRT products pose their own unique set challenges for the ASDC and the Science Teams. Examples of ASDC NRT products and challenges will be discussed.

  8. Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes

    International Nuclear Information System (INIS)

    Gonzalez-Rubio, Sandra; Linares, Clara I.; Bello, Rosario I.; Gonzalez, Raul; Ferrin, Gustavo; Hidalgo, Ana B.; Munoz-Gomariz, Elisa; Rodriguez, Blanca A.; Barrera, Pilar; Ranchal, Isidora; Duran-Prado, Mario; Aguilar-Melero, Patricia; De la Mata, Manuel; Muntane, Jordi

    2010-01-01

    The intracellular oxidative stress has been involved in bile acid-induced cell death in hepatocytes. Nitric oxide (NO) exerts cytoprotective properties in glycochenodeoxycholic acid (GCDCA)-treated hepatocytes. The study evaluated the involvement of Ca 2+ on the regulation of NO synthase (NOS)-3 expression during N-acetylcysteine (NAC) cytoprotection against GCDCA-induced cell death in hepatocytes. The regulation of Ca 2+ pools (EGTA or BAPTA-AM) and NO (L-NAME or NO donor) production was assessed during NAC cytoprotection in GCDCA-treated HepG2 cells. The stimulation of Ca 2+ entrance was induced by A23187 in HepG2. Cell death, Ca 2+ mobilization, NOS-1, -2 and -3 expression, AP-1 activation, and NO production were evaluated. GCDCA reduced intracellular Ca 2+ concentration and NOS-3 expression, and enhanced cell death in HepG2. NO donor prevented, and L-NAME enhanced, GCDCA-induced cell death. The reduction of Ca 2+ entry by EGTA, but not its release from intracellular stores by BAPTA-AM, enhanced cell death in GCDCA-treated cells. The stimulation of Ca 2+ entrance by A23187 reduced cell death and enhanced NOS-3 expression in GCDCA-treated HepG2 cells. The cytoprotective properties of NAC were related to the recovery of intracellular Ca 2+ concentration, NOS-3 expression and NO production induced by GCDCA-treated HepG2 cells. The increase of NO production by Ca 2+ -dependent NOS-3 expression during NAC administration reduces cell death in GCDCA-treated hepatocytes.

  9. Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez-Rubio, Sandra; Linares, Clara I; Bello, Rosario I [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); Gonzalez, Raul; Ferrin, Gustavo [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREH o Ciberehd) (Spain); Hidalgo, Ana B [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); Munoz-Gomariz, Elisa [Department of Biostatistics, Reina Sofia University Hospital, Cordoba (Spain); Rodriguez, Blanca A [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); Barrera, Pilar; Ranchal, Isidora [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREH o Ciberehd) (Spain); Duran-Prado, Mario [Instituto de Parasitologia y Biomedicina Lopez Neyra, CSIC, Granada (Spain); CIBER Fisiopatologia de la Obesidad y Nutricion CB06/03, Instituto de Salud Carlos III, Ministerio de Sanidad y Consumo (Spain); Aguilar-Melero, Patricia [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); De la Mata, Manuel [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREH o Ciberehd) (Spain); Muntane, Jordi [Liver Research Unit, Reina Sofia University Hospital, Cordoba (Spain); Centro de Investigacion Biomedica en Red de Enfermedades Hepaticas y Digestivas (CIBEREH o Ciberehd) (Spain)

    2010-01-15

    The intracellular oxidative stress has been involved in bile acid-induced cell death in hepatocytes. Nitric oxide (NO) exerts cytoprotective properties in glycochenodeoxycholic acid (GCDCA)-treated hepatocytes. The study evaluated the involvement of Ca{sup 2+} on the regulation of NO synthase (NOS)-3 expression during N-acetylcysteine (NAC) cytoprotection against GCDCA-induced cell death in hepatocytes. The regulation of Ca{sup 2+} pools (EGTA or BAPTA-AM) and NO (L-NAME or NO donor) production was assessed during NAC cytoprotection in GCDCA-treated HepG2 cells. The stimulation of Ca{sup 2+} entrance was induced by A23187 in HepG2. Cell death, Ca{sup 2+} mobilization, NOS-1, -2 and -3 expression, AP-1 activation, and NO production were evaluated. GCDCA reduced intracellular Ca{sup 2+} concentration and NOS-3 expression, and enhanced cell death in HepG2. NO donor prevented, and L-NAME enhanced, GCDCA-induced cell death. The reduction of Ca{sup 2+} entry by EGTA, but not its release from intracellular stores by BAPTA-AM, enhanced cell death in GCDCA-treated cells. The stimulation of Ca{sup 2+} entrance by A23187 reduced cell death and enhanced NOS-3 expression in GCDCA-treated HepG2 cells. The cytoprotective properties of NAC were related to the recovery of intracellular Ca{sup 2+} concentration, NOS-3 expression and NO production induced by GCDCA-treated HepG2 cells. The increase of NO production by Ca{sup 2+}-dependent NOS-3 expression during NAC administration reduces cell death in GCDCA-treated hepatocytes.

  10. Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced alteration of colonic transit time in conscious fed rats

    Directory of Open Access Journals (Sweden)

    Ritter Michael

    2005-02-01

    Full Text Available Abstract Background Feeding related peptides have been shown to be additionally involved in the central autonomic control of gastrointestinal functions. Recent studies have shown that ghrelin, a stomach-derived orexigenic peptide, is involved in the autonomic regulation of GI function besides feeding behavior. Pharmacological evidence indicates that ghrelin effects on food intake are mediated by neuropeptide Y in the central nervous system. Methods In the present study we examine the role of ghrelin in the central autonomic control of GI motility using intracerobroventricular and IP microinjections in a freely moving conscious rat model. Further the hypothesis that a functional relationship between NPY and ghrelin within the CNS exists was addressed. Results ICV injections of ghrelin (0.03 nmol, 0.3 nmol and 3.0 nmol/5 μl and saline controls decreased the colonic transit time up to 43%. IP injections of ghrelin (0.3 nmol – 3.0 nmol kg-1 BW and saline controls decreased colonic transit time dose related. Central administration of the NPY1 receptor antagonist, BIBP-3226, prior to centrally or peripherally administration of ghrelin antagonized the ghrelin induced stimulation of colonic transit. On the contrary ICV-pretreatment with the NPY2 receptor antagonist, BIIE-0246, failed to modulate the ghrelin induced stimulation of colonic motility. Conclusion The results suggest that ghrelin acts in the central nervous system to modulate gastrointestinal motor function utilizing NPY1 receptor dependent mechanisms.

  11. Calibration of environmental monitors operating on time integrating principles for radon/thoron decay products

    International Nuclear Information System (INIS)

    Bigu, J.; Grenier, M.

    1982-03-01

    An environmental radiation monitor for radon decay products has been tested under laboratory controlled conditions. The instrument is of a quasi-time-integrating type and was tested in conjunction with a radon 'box' calibration facility. It has been found that the instrument appreciably underestimates the radon daughter Working Level (WL). This is attributed to plate-out of decay products in the monitor sampling head. The difference between monitor reading and the WL by grab-sampling was higher for low aerosol concentrations. Plate-out on the instrument detector and sampling head, and contamination effects have been observed for the thoron case. There is partial agreement between experimental results and theoretical expectation. The monitor is slow to react to sudden changes in radiation level. The instrument should prove quite useful in the routine monitoring of surface and underground environments provided some suggested changes in the instrument are introduced

  12. Productivity and time use during occupational therapy and nutrition/dietetics clinical education: a cohort study.

    Directory of Open Access Journals (Sweden)

    Sylvia Rodger

    Full Text Available BACKGROUND: Currently in the Australian higher education sector higher productivity from allied health clinical education placements is a contested issue. This paper will report results of a study that investigated output changes associated with occupational therapy and nutrition/dietetics clinical education placements in Queensland, Australia. Supervisors' and students' time use during placements and how this changes for supervisors compared to when students are not present in the workplace is also presented. METHODOLOGY/PRINCIPAL FINDINGS: A cohort design was used with students from four Queensland universities, and their supervisors employed by Queensland Health. There was an increasing trend in the number of occasions of service delivered when the students were present, and a statistically significant increase in the daily mean length of occasions of service delivered during the placement compared to pre-placement levels. CONCLUSIONS/SIGNIFICANCE: A novel method for estimating productivity and time use changes during clinical education programs for allied health disciplines has been applied. During clinical education placements there was a net increase in outputs, suggesting supervisors engage in longer consultations with patients for the purpose of training students, while maintaining patient numbers. Other activities were reduced. This paper is the first time these data have been shown in Australia and form a sound basis for future assessments of the economic impact of student placements for allied health disciplines.

  13. IL-1β Suppresses the Formation of Osteoclasts by Increasing OPG Production via an Autocrine Mechanism Involving Celecoxib-Related Prostaglandins in Chondrocytes

    Directory of Open Access Journals (Sweden)

    Yusuke Watanabe

    2009-01-01

    Full Text Available Elevated interleukin (IL-1 concentrations in synovial fluid have been implicated in joint bone and cartilage destruction. Previously, we showed that IL-1β stimulated the expression of prostaglandin (PG receptor EP4 via increased PGE2 production. However, the effect of IL-1β on osteoclast formation via chondrocytes is unclear. Therefore, we examined the effect of IL-1β and/or celecoxib on the expression of macrophage colony-stimulating factor (M-CSF, receptor activator of NF-κB ligand (RANKL, and osteoprotegerin (OPG in human chondrocytes, and the indirect effect of IL-1β on osteoclast-like cell formation using RAW264.7 cells. OPG and RANKL expression increased with IL-1β; whereas M-CSF expression decreased. Celecoxib blocked the stimulatory effect of IL-1β. Conditioned medium from IL-1β-treated chondrocytes decreased TRAP staining in RAW264.7 cells. These results suggest that IL-1β suppresses the formation of osteoclast-like cells via increased OPG production and decreased M-CSF production in chondrocytes, and OPG production may increase through an autocrine mechanism involving celecoxib-related PGs.

  14. Can High-involvement Innovation Practices improve Productivity and the Quality of Working-life simultaneously? Management and Employee Views on Comparison

    Directory of Open Access Journals (Sweden)

    Elise Ramstad

    2015-01-01

    Full Text Available This paper examines the association of high-involvement innovation practices (HIIPs and simultaneous improvement of productivity and the quality of working life (QWL. HIIPs refer to work, managerial, and organizational practices that are intended for supporting continuous improvement and broad participation. The data are based on the evaluation surveys carried out by the Finnish Workplace Development Programme TYKES (2004–2010. TYKES was a governmental programme for promoting simultaneous improvements in productivity and the QWL in workplaces through changes in work, managerial, and organizational practices. Information obtained via two different surveys has been combined for the purposes of this article: a survey on HIIPs within a work organization (HIIP and a self-assessment survey of project outcomes (SA. The survey material comprises altogether 253 responses from 163 different workplaces. The analysis provides evidence in favor of a view that publicly funded workplace development projects constitute appropriate means to support productivity and the QWL simultaneously. The results provide evidence that HIIPs, including decentralized decision making, competence development, internal cooperation, and external cooperation, are of importance when trying to gain better results in both productivity and the QWL from both management and employees’ point of view. In addition, the development process itself, that is, how the practices are implemented and good skills in project management, is highlighted. Concerning the supervisor’s supportive role in employees’ innovation activities, the picture is more mixed and surprising.

  15. Fast Estimation Method of Space-Time Two-Dimensional Positioning Parameters Based on Hadamard Product

    Directory of Open Access Journals (Sweden)

    Haiwen Li

    2018-01-01

    Full Text Available The estimation speed of positioning parameters determines the effectiveness of the positioning system. The time of arrival (TOA and direction of arrival (DOA parameters can be estimated by the space-time two-dimensional multiple signal classification (2D-MUSIC algorithm for array antenna. However, this algorithm needs much time to complete the two-dimensional pseudo spectral peak search, which makes it difficult to apply in practice. Aiming at solving this problem, a fast estimation method of space-time two-dimensional positioning parameters based on Hadamard product is proposed in orthogonal frequency division multiplexing (OFDM system, and the Cramer-Rao bound (CRB is also presented. Firstly, according to the channel frequency domain response vector of each array, the channel frequency domain estimation vector is constructed using the Hadamard product form containing location information. Then, the autocorrelation matrix of the channel response vector for the extended array element in frequency domain and the noise subspace are calculated successively. Finally, by combining the closed-form solution and parameter pairing, the fast joint estimation for time delay and arrival direction is accomplished. The theoretical analysis and simulation results show that the proposed algorithm can significantly reduce the computational complexity and guarantee that the estimation accuracy is not only better than estimating signal parameters via rotational invariance techniques (ESPRIT algorithm and 2D matrix pencil (MP algorithm but also close to 2D-MUSIC algorithm. Moreover, the proposed algorithm also has certain adaptability to multipath environment and effectively improves the ability of fast acquisition of location parameters.

  16. Effect of cycle time on polyhydroxybutyrate (PHB) production in aerobic mixed cultures.

    Science.gov (United States)

    Ozdemir, Sebnem; Akman, Dilek; Cirik, Kevser; Cinar, Ozer

    2014-03-01

    The aim of this study was to investigate the effect of cycle time on polyhydroxybutyrate (PHB) production under aerobic dynamic feeding system. The acetate-fed feast and famine sequencing batch reactor was used to enrich PHB accumulating microorganism. Sequencing batch reactor (SBR) was operated in four different cycle times (12, 8, 4, and 2 h) fed with a synthetic wastewater. The system performance was determined by monitoring total dissolved organic carbon, dissolved oxygen, oxidation-reduction potential, and PHB concentration. In this study, under steady-state conditions, the feast period of the SBR was found to allow the PHB storage while a certain part of stored PHB was used for continued growth in famine period. The percentage PHB storages by aerobic microorganism were at 16, 18, 42, and 55% for the 12, 8, 4, and 2-h cycle times, respectively. The PHB storage was increased as the length of the cycle time was decreased, and the ratio of the feast compared to the total cycle length was increased from around 13 to 33% for the 12 and 2-h cycle times, respectively.

  17. Can increasing adult vaccination rates reduce lost time and increase productivity?

    Science.gov (United States)

    Rittle, Chad

    2014-12-01

    This article addresses limited vaccination coverage by providing an overview of the epidemiology of influenza, pertussis, and pneumonia, and the impact these diseases have on work attendance for the worker, the worker's family, and employer profit. Studies focused on the cost of vaccination programs, lost work time, lost employee productivity and acute disease treatment are discussed, as well as strategies for increasing vaccination coverage to reduce overall health care costs for employers. Communicating the benefits of universal vaccination for employees and their families and combating vaccine misinformation among employees are outlined. Copyright 2014, SLACK Incorporated.

  18. Global, Daily, Near Real-Time Satellite-based Flood Monitoring and Product Dissemination

    Science.gov (United States)

    Slayback, D. A.; Policelli, F. S.; Brakenridge, G. R.; Tokay, M. M.; Smith, M. M.; Kettner, A. J.

    2013-12-01

    provide better spatial resolution, this typically comes at the cost of being less timely. Since late 2011, this system has been providing daily flood maps of the global non-antarctic land surface. These data products are generated in raster and vector formats, and provided freely on our website. To better serve the disaster response community, we have recently begun providing the products via live OGC (Open Geospatial Consortium) services, allowing easy access in a variety of platforms (Google Earth, desktop GIS software, mobile phone apps). We are also working with the Pacific Disaster Center to bring our product into their Disaster Alert system (including a mobile app), which will help simplify product distribution to the disaster management community.

  19. Resonant e+e- production by time-varying electromagnetic field

    International Nuclear Information System (INIS)

    Farakos, K.; Koutsoumbas, G.; Tiktopoulos, G.

    1990-01-01

    As pointed out by Cornwall and Tiktopoulos (CT) strong, time-varying electric fields may produce e + e - pairs in a resonant fashion. This effect could be related to the sharp peaks in the e + e - spectrum observed in the GSI heavy-ion collision experiments. We attempt to go beyond the case of spatially uniform fields discussed by CT. We find that resonant e + e - production indeed takes place for electric fields derived from four-potentials of the form A 1 =A 2 =A 0 =0, A 3 =δ(t)b(x 3 ) provided by b(x) has discontinuities with a jump at least equal to π. (orig.)

  20. A continuous time inventory model for a product recovery system with multiple options

    NARCIS (Netherlands)

    Kleber, R.; Minner, S.; Kiesmüller, G.P.

    2002-01-01

    Increasing environmental consciousness, limited availability of natural resources to manufacture new products, recovery quotas to avoid disposal, manufacturers assigned to be responsible for used products, and materials value of components included in returned products are incentives for product

  1. Trends in Deaths Involving Heroin and Synthetic Opioids Excluding Methadone, and Law Enforcement Drug Product Reports, by Census Region - United States, 2006-2015.

    Science.gov (United States)

    O'Donnell, Julie K; Gladden, R Matthew; Seth, Puja

    2017-09-01

    Opioid overdose deaths quadrupled from 8,050 in 1999 to 33,091 in 2015 and accounted for 63% of drug overdose deaths in the United States in 2015. During 2010-2015, heroin overdose deaths quadrupled from 3,036 to 12,989 (1). Sharp increases in the supply of heroin and illicitly manufactured fentanyl (IMF) are likely contributing to increased deaths (2-6). CDC examined trends in unintentional and undetermined deaths involving heroin or synthetic opioids excluding methadone (i.e., synthetic opioids)* by the four U.S. Census regions during 2006-2015. Drug exhibits (i.e., drug products) obtained by law enforcement and reported to the Drug Enforcement Administration's (DEA's) National Forensic Laboratory Information System (NFLIS) that tested positive for heroin or fentanyl (i.e., drug reports) also were examined. All U.S. Census regions experienced substantial increases in deaths involving heroin from 2006 to 2015. Since 2010, the South and West experienced increases in heroin drug reports, whereas the Northeast and Midwest experienced steady increases during 2006-2015. † In the Northeast, Midwest, and South, deaths involving synthetic opioids and fentanyl drug reports increased considerably after 2013. These broad changes in the U.S. illicit drug market highlight the urgent need to track illicit drugs and enhance public health interventions targeting persons using or at high risk for using heroin or IMF.

  2. IP3 production in the hypersensitive response of lemon seedlings against Alternaria alternata involves active protein tyrosine kinases but not a G-protein

    Directory of Open Access Journals (Sweden)

    XIMENA ORTEGA

    2005-01-01

    Full Text Available IP3 increase and de novo synthesis of scoparone are produced in the hypersensitive response (HR of lemon seedlings against the fungus Alternaria alternata. To elucidate whether a G-protein and/or a protein tyrosine kinase (PTK are involved in signal transduction leading to the production of such a defensive response, we studied the HR in this plant system after treatment with G-protein activators alone and PTK inhibitors in the presence of fungal conidia. No changes in the level of IP3 were detected in response to the treatment with the G-protein activators cholera toxin or mastoparan, although the HR was observed in response to these compounds as determined by the scoparone synthesis. On the contrary, the PTK inhibitors lavendustin A and 2,5-dihidroxy methyl cinnamate (DHMC not only prevented the IP3 changes observed in response to the fungal inoculation of lemon seedlings but also blocked the development of the HR. These results suggest that the IP3 changes observed in response to A. alternata require a PTK activity and are the result of a G-protein independent Phospholipase C activity, even though the activation of a G-protein can also lead to the development of a HR. Therefore, it appears that more than one signaling pathway may be activated for the development of HR in lemon seedlings: one involving a G-protein and the other involving a PTK-dependent PLC.

  3. Reported implementation lessons from a national quality improvement initiative; Productive Ward: Releasing Time to Care™. A qualitative, ward-based team perspective.

    Science.gov (United States)

    White, Mark; Butterworth, Tony; Wells, John S G

    2017-10-01

    To explore the experiences of participants involved in the implementation of the Productive Ward: Releasing Time to Care™ initiative in Ireland, identifying key implementation lessons. A large-scale quality improvement programme Productive Ward: Releasing Time to Care™ was introduced nationwide into Ireland in 2011. We captured accounts from ward-based teams in an implementation phase during 2013-14 to explore their experiences. Semi-structured, in-depth interviews with a purposive sample of 24 members of ward-based teams from nine sites involved in the second national phase of the initiative were conducted. Interviews were analysed and coded under themes, using a seven-stage iterative process. The predominant theme identified was associated with the implementation and management of the initiative and included: project management; training; preparation; information and communication; and participant's negative experiences. The most prominent challenge reported related to other competing clinical priorities. Despite the structured approach of Productive Ward: Releasing Time to Care™, it appears that overstretched and busy clinical environments struggle to provide the right climate and context for ward-based teams to engage and interact actively with quality improvement tools, methods and activities. Findings highlight five key aspects of implementation and management that will help facilitate successful adoption of large-scale, ward-based quality improvement programmes such as Productive Ward: Releasing Time to Care™. Utilising pre-existing implementation or quality frameworks to assess each ward/unit for 'readiness' prior to commencing a quality improvement intervention such as Productive Ward: Releasing Time to Care™ should be considered. © 2017 John Wiley & Sons Ltd.

  4. The Dubna double-arm time-of-flight spectrometer for heavy-ion reaction products

    International Nuclear Information System (INIS)

    Schilling, K.D.; Gippner, P.; Seidel, W.; Stary, F.; Will, E.; Heidel, K.; Lukyanov, S.M.; Penionzhkevich, Yu.E.; Salamatin, V.S.; Sodan, H.; Chubarian, G.G.

    1986-05-01

    The double-arm time-of-flight spectrometer DEMAS designed for the detection and identification of heavy-ion reaction products at incident energies below 10 MeV/amu is presented. Based on the kinematic coincidence method, the relevant physical information is obtained from the measurement of the two correlated velocity vectors of the binary fragments. Construction and performance of the different detector systems applied to measure the time-of-flight values, the position coordinates and the kinetic energies of both fragments are presented in detail. The description of the data acquisition and analysing procedures is followed by the discussion of some experimental examples to demonstrate the spectrometer performance. A mass resolution of typically 4 - 5 amu (fwhm) is routinely achieved. (author)

  5. Choice of foods: Allocation of time and money, household production and market services ­ Part II

    DEFF Research Database (Denmark)

    Bonke, Jens

    1993-01-01

    Executive summary: 1. This is the second report on a study investigating how demand for food products with varying degrees of convenience depends on disposable income and disposable time. 2. Both absolute and relative expenditures on convenient food decrease with disposable time and increase...... in Denmark. This contrasts with Sweden, where higher education leads to more expenditure on fast food. This may indicate a slower pace of modernisation of eating habits in Denmark than in Sweden. 6. Ownership of microwave ovens and dishwashers means more expenditure on fast meals. Ownership of a freezer...... means reduced expenses on most kinds of foodstuffs, possibly due to obtaining quantity discounts. 7. Ownership of household appliances and hiring domestic help decreases the probability of eating out. 8. Singles spend money on meals away from home more frequently than couples, whereas the spending...

  6. Development of Aa New Time Temperature Indicator for Enzymatic Validation of Pasteurization of Meat Products.

    Science.gov (United States)

    Brizio, Ana Paula Dutra Resem; Prentice, Carlos

    2015-06-01

    This paper presents the development of a new smart time-temperature indicator (TTI) of pasteurization whose operating principle is based on the complexation reaction between starch and iodine, and the subsequent action of an amylase on this complex causing its discoloration at a rate dependent on time and temperature of the medium. Laboratory simulations and tests in a manufacturing plant evaluated different enzyme concentrations in the TTI prototypes when exposed to pasteurization conditions. The results showed that the color response of the indicators was visually interpreted as adaptive to measurement using appropriate equipment, with satisfactory reliability in all conditions studied. The TTI containing 6.5% amylase was one whose best results were suited for use in validating the cooking of hams. When attached to the primary packaging of the product, this TTI indicated the pasteurization process inexpensively, easily, accurately, and nondestructively. © 2015 Institute of Food Technologists®

  7. Status of IGS Ultra-Rapid Products for Real-Time Applications

    Science.gov (United States)

    Ray, J.; Griffiths, J.

    2008-12-01

    Since November 2000 the International GNSS Service (IGS) has produced Ultra-rapid (IGU) products for near real-time and real-time applications. They include GPS orbits, satellite clocks, and Earth rotation parameters for a sliding 48-hr period. The first day of each update is based on the most recent GPS observational data from the IGS hourly tracking network. At the time of release, these observed products have an initial latency of 3 hr. The second day of each update consists of predictions. So the predictions between about 3 and 9 hr into the second half are relevant for true real-time uses. Originally updated twice daily, the IGU products since April 2004 have been issued four times per day, at 3, 9, 15, and 21 UTC. Up to seven Analysis Centers (ACs) contribute to the IGU combinations: Astronomical Institute of the University of Berne (AIUB), European Space Operations Center (ESOC), Geodetic Observatory Pecny (GOP), GeoForschungsZentrum (GFZ) Potsdam, Natural Resources Canada (NRC), Scripps Insitution of Oceanography (SIO), U.S. Naval Observatory (USNO). This redundancy affords a high measure of reliability and enhanced orbit accuracy. IGU orbit precision has improved markedly since late 2007. This is due to a combination of factors: decommissioning of the old, poorly behaved PRN29 in October 2007; upgraded procedures implemented by GOP around the same time, by SIO in spring 2008, and by USNO in June 2008; better handling of maneuvered satellites at the combination level starting June 2008; and stricter AC rejection criteria since July 2008. As a consequence, the weighted 1D RMS residual of the IGU orbit predictions over their first 6 hr is currently about 20 to 30 mm (after a Helmert transformation) compared to the IGS Rapid orbits, averaged over the constellation. The median residual is about 15 to 20 mm. When extended to the full 24 hr prediction period, the IGU orbit errors approximately double. Systematic rotational offsets are probably more important than

  8. A Preliminary Examination of the Second Generation CMORPH Real-time Production

    Science.gov (United States)

    Joyce, R.; Xie, P.; Wu, S.

    2017-12-01

    The second generation CMORPH (CMORPH2) has started test real-time production of 30-minute precipitation estimates on a 0.05olat/lon grid over the entire globe, from pole-to-pole. The CMORPH2 is built upon the Kalman Filter based CMORPH algorithm of Joyce and Xie (2011). Inputs to the system include rainfall and snowfall rate retrievals from passive microwave (PMW) measurements aboard all available low earth orbit (LEO) satellites, precipitation estimates derived from infrared (IR) observations of geostationary (GEO) and LEO platforms, and precipitation simulations from the NCEP operational global forecast system (GFS). Inputs from the various sources are first inter-calibrated to ensure quantitative consistencies in representing precipitation events of different intensities through PDF calibration against a common reference standard. The inter-calibrated PMW retrievals and IR-based precipitation estimates are then propagated from their respective observation times to the target analysis time along the motion vectors of the precipitating clouds. Motion vectors are first derived separately from the satellite IR based precipitation estimates and the GFS precipitation fields. These individually derived motion vectors are then combined through a 2D-VAR technique to form an analyzed field of cloud motion vectors over the entire globe. The propagated PMW and IR based precipitation estimates are finally integrated into a single field of global precipitation through the Kalman Filter framework. A set of procedures have been established to examine the performance of the CMORPH2 real-time production. CMORPH2 satellite precipitation estimates are compared against the CPC daily gauge analysis, Stage IV radar precipitation over the CONUS, and numerical model forecasts to discover potential shortcomings and quantify improvements against the first generation CMORPH. Special attention has been focused on the CMORPH behavior over high-latitude areas beyond the coverage of the first

  9. The effect of organic loading rate and retention time on hydrogen production from a methanogenic CSTR.

    Science.gov (United States)

    Pakarinen, O; Kaparaju, P; Rintala, J

    2011-10-01

    The possibility of shifting a methanogenic process for hydrogen production by changing the process parameters viz., organic loading rate (OLR) and hydraulic retention time (HRT) was evaluated. At first, two parallel semi-continuously fed continuously stirred tank reactors (CSTR) were operated as methanogenic reactors (M1 and M2) for 78 days. Results showed that a methane yield of 198-218 L/kg volatile solids fed (VS(fed)) was obtained when fed with grass silage at an OLR of 2 kgVS/m³/d and HRT of 30 days. After 78 days of operation, hydrogen production was induced in M2 by increasing the OLR from 2 to 10 kgVS/m³/d and shortening the HRT from 30 to 6 days. The highest H₂ yield of 42 L/kgVS(fed) was obtained with a maximum H₂ content of 24%. The present results thus demonstrate that methanogenic process can be shifted towards hydrogen production by increasing the OLR and decreasing HRT. Copyright © 2011 Elsevier Ltd. All rights reserved.

  10. Electric energy production and environmental licensing: citizenship in Brazil in time of ecological crisis

    International Nuclear Information System (INIS)

    Bettencourt, Marcia Pires da Luz

    2017-01-01

    The choices of energy sources gain relevance in the face of the ecological crisis which has a central questioning on the modes of production and consumption and that stems from a system which changes everything into merchandise. On one hand, brazilian electricity generation has the advantage of using clean energy in great part of its composition, at least in discourse. On the other hand, though, there are high social and environmental costs, especially for communities living near the regions where projects for the electricity sector are built. This research aimed to identify and analyse different modes society takes part in the process of choosing energy sources for electricity generation in Brazil. It discusses the links between the ecological crisis and the production of electrical energy; how the institutional mechanisms for social participation on issues related to the production of electric power in Brazil work; and, how civil society participates in environmental licensing in the National Environment Council (CONAMA). A set of related approaches to the nature of the ecological crisis and the forms of social participation was adopted in the theoretical framework and an analysis of the electric sector panorama in Brazil has been drawn up. In order to investigate the forms society participates in issues related to the composition of the brazilian electricity matrix, the methodology comprised a documentary analysis and a case study. They included three categories of actors: (1) CONAMA's councilors, (2) experts from the Field; and (3) actors involved in the diagnosis study, planning and management of the electricity sector. The research identified inconsistencies, ambiguities and other relevant issues about the participation of society in the production of electrical energy. Such issues are related to: deficiencies in the mechanisms for information access; lack of transparency and patterns in internal documents; lack of social participation in the elaboration of

  11. Detecting subsurface fluid leaks in real-time using injection and production rates

    Science.gov (United States)

    Singh, Harpreet; Huerta, Nicolas J.

    2017-12-01

    CO2 injection into geologic formations for either enhanced oil recovery or carbon storage introduces a risk for undesired fluid leakage into overlying groundwater or to the surface. Despite decades of subsurface CO2 production and injection, the technologies and methods for detecting CO2 leaks are still costly and prone to large uncertainties. This is especially true for pressure-based monitoring methods, which require the use of simplified geological and reservoir flow models to simulate the pressure behavior as well as background noise affecting pressure measurements. In this study, we propose a method to detect the time and volume of fluid leakage based on real-time measurements of well injection and production rates. The approach utilizes analogies between fluid flow and capacitance-resistance modeling. Unlike other leak detection methods (e.g. pressure-based), the proposed method does not require geological and reservoir flow models to simulate the behavior that often carry significant sources of uncertainty; therefore, with our approach the leak can be detected with greater certainty. The method can be applied to detect when a leak begins by tracking a departure in fluid production rate from the expected pattern. The method has been tuned to detect the effect of boundary conditions and fluid compressibility on leakage. To highlight the utility of this approach we use our method to detect leaks for two scenarios. The first scenario simulates a fluid leak from the storage formation into an above-zone monitoring interval. The second scenario simulates intra-reservoir migration between two compartments. We illustrate this method to detect fluid leakage in three different reservoirs with varying levels of geological and structural complexity. The proposed leakage detection method has three novelties: i) requires only readily-available data (injection and production rates), ii) accounts for fluid compressibility and boundary effects, and iii) in addition to

  12. REDUCTION OF MORTADELLA COOKING TIME AND EVALUATION OF THE FINAL PRODUCT QUALITY

    Directory of Open Access Journals (Sweden)

    Diones Orsolin

    2015-10-01

    Full Text Available In food industry, the cooking is one of the most important processes for the conservation and quality assurance of the final product, especially mortadella. However, this process requires high investment in modern equipment besides having energy and steam expenses.. In this context, the objective of this study was to propose a cooking method of mortadella produced with pork and chicken, by reducing time and increasing temperature inside the baking oven. Evaluations of behavior of water activity, pH and texture of the mortadella were carried out throughout shelf life. From the results, we found that both pork and chicken mortadella that were cooked by the current process and those that passed through the cooking process with reduced time showed no significant differences at the level of 95% confidence for the analyzed characteristics. Therefore, all treatments had similar values and can be considered within the established standards of product quality for both water activity and for pH and texture.

  13. Time series from hyperion to track productivity in pivot agriculture in saudi arabia

    KAUST Repository

    Houborg, Rasmus

    2017-12-13

    The hyperspectral satellite sensing capacity is expected to increase substantially in the near future with the planned deployment of hyperspectral systems by both space agencies and commercial companies. These enhanced observational resources will offer new and improved ways to monitor the dynamics and characteristics of terrestrial ecosystems. This study investigates the utility of time series of hyperspectral imagery, acquired by Hyperion onboard EO-1, for quantifying variations in canopy chlorophyll (Chlc), plant productivity, and yield over an intensive farming area in the desert of Saudi Arabia. Chlc is estimated on the basis of predictive multi-variate empirical models established via a machine learning approach using a training dataset of in-situ measured target variables and explanatory hyperspectral indices. Resulting time series of Chlc are translated into Gross Primary Productivity (GPP) and Yield based on semi-empirical relationships, and evaluated against ground-based observations. Results indicate significant benefit in utilizing the full suite of hyperspectral indices over multi-spectral indices constructible from Landsat-8 and Sentinel-2.

  14. The effect of temperature and Pasteurization time on Staphylococcus aureus isolates from dairy products

    Science.gov (United States)

    Yaniarti, Maria Nia; Amarantini, Charis; Budiarso, Tri Yahya

    2017-11-01

    Staphylococcus aureus is a potential pathogenic bacterial cause of disease in humans and animals due to the ability of adhesion to epithelial tissue. Many cases of food poisoning are caused by S. aureus bacteria. Therefore, the purpose of this study was to determine the effect of temperature and time on the growth of S. aureus isolates from milk products. The samples are derived from previous research namely pasteurized milk, street vendor and café milk, milk powder, and sweetened condensed milk products. The treatment temperatures and times studied were temperature 60 °C, 65 °C, 70 °C, 75 °C, 80 °C, and 30, 35, 40, 45, 50, 55, and 60 minutes. The results show that at temperatures of 60 °C and 65 °C, S. aureus isolates did not grow at 60 minutes. All isolates of S. aureus died when the temperatures were increased to 70 °C and 80 °C, at 50 and 20 minutes, respectively.

  15. Time series from hyperion to track productivity in pivot agriculture in saudi arabia

    KAUST Repository

    Houborg, Rasmus; McCabe, Matthew; Angel, Yoseline; Middleton, Elizabeth M.

    2017-01-01

    The hyperspectral satellite sensing capacity is expected to increase substantially in the near future with the planned deployment of hyperspectral systems by both space agencies and commercial companies. These enhanced observational resources will offer new and improved ways to monitor the dynamics and characteristics of terrestrial ecosystems. This study investigates the utility of time series of hyperspectral imagery, acquired by Hyperion onboard EO-1, for quantifying variations in canopy chlorophyll (Chlc), plant productivity, and yield over an intensive farming area in the desert of Saudi Arabia. Chlc is estimated on the basis of predictive multi-variate empirical models established via a machine learning approach using a training dataset of in-situ measured target variables and explanatory hyperspectral indices. Resulting time series of Chlc are translated into Gross Primary Productivity (GPP) and Yield based on semi-empirical relationships, and evaluated against ground-based observations. Results indicate significant benefit in utilizing the full suite of hyperspectral indices over multi-spectral indices constructible from Landsat-8 and Sentinel-2.

  16. A Timed Colored Petri Net Simulation-Based Self-Adaptive Collaboration Method for Production-Logistics Systems

    OpenAIRE

    Zhengang Guo; Yingfeng Zhang; Xibin Zhao; Xiaoyu Song

    2017-01-01

    Complex and customized manufacturing requires a high level of collaboration between production and logistics in a flexible production system. With the widespread use of Internet of Things technology in manufacturing, a great amount of real-time and multi-source manufacturing data and logistics data is created, that can be used to perform production-logistics collaboration. To solve the aforementioned problems, this paper proposes a timed colored Petri net simulation-based self-adaptive colla...

  17. The effect of stricter licensing on road traffic injury events involving 15 to 17-year-old moped drivers in Sweden: A time series intervention study.

    Science.gov (United States)

    Bonander, Carl; Andersson, Ragnar; Nilson, Finn

    2015-10-01

    This study aimed to evaluate and quantify the effect of the introduction of the AM driving license on non-fatal moped-related injuries in Sweden. With the introduction of the new license category in October 2009, prospective moped drivers are now required to pass a mandatory theory test following a practical and theoretical course. In addition, obtaining a license to operate a moped is now considerably more costly. Time series intervention analysis on monthly aggregated injury data (1st Jan 2007-31st Dec 2013) was performed using generalized additive models for location, shape and scale (GAMLSS) to quantify the effect size on injury events involving teenage (15-17 years) moped drivers, while controlling for trend and seasonality. Exposure was adjusted for by using the number of registered mopeds in traffic as a proxy. The introduction of AM license was associated with a 41% reduction in the rate of injury events involving 15-year-old moped drivers (IRR 0.59 [95% CI: 0.48-0.72]), and a 39% and 36% decrease in those involving 16-year-old (IRR 0.61 [95% CI: 0.48-0.79]) and 17-year-old drivers (IRR 0.64 [95% CI: 0.46-0.90]), respectively. The effect in the 15-year-old stratum was decreased roughly by half after adjusting for exposure, but remained significant, and the corresponding estimates in the other age groups did not change noticeably. This study provides quasi-experimental evidence of an effect on non-fatal moped-related injuries as a result of stricter licensing rules. Only part of the effect could be explained by a reduction in the number of mopeds in traffic, indicating that other mechanisms must be studied to fully understand the cause of the reduction in injuries. Copyright © 2015 Elsevier Ltd. All rights reserved.

  18. Rational and timely haemostatic interventions following cardiac surgery - coagulation factor concentrates or blood bank products.

    Science.gov (United States)

    Tang, Mariann; Fenger-Eriksen, Christian; Wierup, Per; Greisen, Jacob; Ingerslev, Jørgen; Hjortdal, Vibeke; Sørensen, Benny

    2017-06-01

    Cardiac surgery may cause a serious coagulopathy leading to increased risk of bleeding and transfusion demands. Blood bank products are commonly first line haemostatic intervention, but has been associated with hazardous side effect. Coagulation factor concentrates may be a more efficient, predictable, and potentially a safer treatment, although prospective clinical trials are needed to further explore these hypotheses. This study investigated the haemostatic potential of ex vivo supplementation of coagulation factor concentrates versus blood bank products on blood samples drawn from patients undergoing cardiac surgery. 30 adults were prospectively enrolled (mean age=63.9, females=27%). Ex vivo haemostatic interventions (monotherapy or combinations) were performed in whole blood taken immediately after surgery and two hours postoperatively. Fresh-frozen plasma, platelets, cryoprecipitate, fibrinogen concentrate, prothrombin complex concentrate (PCC), and recombinant FVIIa (rFVIIa) were investigated. The haemostatic effect was evaluated using whole blood thromboelastometry parameters, as well as by thrombin generation. Immediately after surgery the compromised maximum clot firmness was corrected by monotherapy with fibrinogen or platelets or combination therapy with fibrinogen. At two hours postoperatively the coagulation profile was further deranged as illustrated by a prolonged clotting time, a reduced maximum velocity and further diminished maximum clot firmness. The thrombin lagtime was progressively prolonged and both peak thrombin and endogenous thrombin potential were compromised. No monotherapy effectively corrected all haemostatic abnormalities. The most effective combinations were: fibrinogen+rFVIIa or fibrinogen+PCC. Blood bank products were not as effective in the correction of the coagulopathy. Coagulation factor concentrates appear to provide a more optimal haemostasis profile following cardiac surgery compared to blood bank products. Copyright © 2017

  19. Breastfeeding Initiation and Duration in First-Time Mothers: Exploring the Impact of Father Involvement in the Early Post-Partum Period

    Directory of Open Access Journals (Sweden)

    Theresa Hunter

    2014-12-01

    Full Text Available Background: The early post-partum period is a crucial time for breastfeeding support. Mothers who have physical and emotional support during this period are more likely to be successful in breastfeeding. This study examined the relationship between father involvement and support for breast feeding initiation and duration in first-time mothers. Methods: Overall, 146 women who attended a childbirth education class or breastfeeding course at BABS were asked to fill out the Childbirth Experiences Survey, which explored key topics such as (1 breastfeeding initiation, (2 early post-partum breastfeeding, (3 breastfeeding plan, (4 post-partum breastfeeding support and (5 breast feeding duration. This was a voluntary self-reported questionnaire. The surveys were completed by the mothers during the post-partum period. Results: 45.9% (n=67 of mothers received helped from their husband or partner with breastfeeding while in the hospital, while 54.1% (n=79 of mothers did not receive support from their partners. Mothers who received early post-partum breastfeeding support were more likely to continue breastfeeding after leaving the hospital. Conclusion: First-time mothers who identified as having breastfeeding support from their partners, the infant’s father, during the early post-partum period were more likely to initiate breastfeeding and had longer breastfeeding durations.

  20. Product evolution: how new (types of) products come about & develop over time into families of advanced versions

    NARCIS (Netherlands)

    Ehlhardt, Huub

    2016-01-01

    This thesis presents a Theory of Product Evolution which builds on the work of many scholars who have described evolutionary patterns in innovation processes. It challenges the popular notion that we owe the availability of products solely to genius inventors. Instead arguments are presented to show

  1. Factors associated with regulatory action involving investigation of illnesses associated with Shiga toxin-producing Escherichia coli in products regulated by the Food Safety and Inspection Service.

    Science.gov (United States)

    Green, Alice L; Seys, Scott; Douris, Aphrodite; Levine, Jeoff; Robertson, Kis

    2014-07-01

    We described characteristics of the Escherichia coli O157 and Escherichia coli non-O157 illness investigations conducted by the United States Department of Agriculture's Food Safety and Inspection Service (FSIS) during the 5-year period from 2006 through 2010. We created a multivariable logistic regression model to determine characteristics of these investigations that were associated with FSIS regulatory action, which was defined as having occurred if a product recall occurred or if FSIS personnel performed an environmental health assessment (Food Safety Assessment) at the implicated establishment. During this period, FSIS took regulatory action in 38 of 88 (43%) investigations. Illness investigations in which FoodNet states were involved were more likely to result in regulatory action. Illness investigations in which state and local traceback, or FSIS traceback occurred were more likely to result in regulatory action. Reasons for lack of action included evidence of cross-contamination after the product left a regulated establishment, delayed notification, lack of epidemiological information, and insufficient product information.

  2. Increased production of biomass-degrading enzymes by double deletion of creA and creB genes involved in carbon catabolite repression in Aspergillus oryzae.

    Science.gov (United States)

    Ichinose, Sakurako; Tanaka, Mizuki; Shintani, Takahiro; Gomi, Katsuya

    2018-02-01

    In a previous study, we reported that a double gene deletion mutant for CreA and CreB, which constitute the regulatory machinery involved in carbon catabolite repression, exhibited improved production of α-amylase compared with the wild-type strain and single creA or creB deletion mutants in Aspergillus oryzae. Because A. oryzae can also produce biomass-degrading enzymes, such as xylolytic and cellulolytic enzymes, we examined the production levels of those enzymes in deletion mutants in this study. Xylanase and β-glucosidase activities in the wild-type were hardly detected in submerged culture containing xylose as the carbon source, whereas those enzyme activities were significantly increased in the single creA deletion (ΔcreA) and double creA and creB deletion (ΔcreAΔcreB) mutants. In particular, the ΔcreAΔcreB mutant exhibited >100-fold higher xylanase and β-glucosidase activities than the wild-type. Moreover, in solid-state culture, the β-glucosidase activity of the double deletion mutant was >7-fold higher than in the wild-type. These results suggested that deletion of both creA and creB genes could also efficiently improve the production levels of biomass-degrading enzymes in A. oryzae. Copyright © 2017 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

  3. Involvement of PI3K/AKT and MAPK Pathways for TNF-α Production in SiHa Cervical Mucosal Epithelial Cells Infected with Trichomonas vaginalis.

    Science.gov (United States)

    Yang, Jung-Bo; Quan, Juan-Hua; Kim, Ye-Eun; Rhee, Yun-Ee; Kang, Byung-Hyun; Choi, In-Wook; Cha, Guang-Ho; Yuk, Jae-Min; Lee, Young-Ha

    2015-08-01

    Trichomonas vaginalis; induces proinflammation in cervicovaginal mucosal epithelium. To investigate the signaling pathways in TNF-α production in cervical mucosal epithelium after T. vaginalis infection, the phosphorylation of PI3K/AKT and MAPK pathways were evaluated in T. vaginalis-infected SiHa cells in the presence and absence of specific inhibitors. T. vaginalis increased TNF-α production in SiHa cells, in a parasite burden-dependent and incubation time-dependent manner. In T. vaginalis-infected SiHa cells, AKT, ERK1/2, p38 MAPK, and JNK were phosphorylated from 1 hr after infection; however, the phosphorylation patterns were different from each other. After pretreatment with inhibitors of the PI3K/AKT and MAPK pathways, TNF-α production was significantly decreased compared to the control; however, TNF-α reduction patterns were different depending on the type of PI3K/MAPK inhibitors. TNF-α production was reduced in a dose-dependent manner by treatment with wortmannin and PD98059, whereas it was increased by SP600125. These data suggested that PI3K/AKT and MAPK signaling pathways are important in regulation of TNF-α production in cervical mucosal epithelial SiHa cells. However, activation patterns of each pathway were different from the types of PI3K/MAPK pathways.

  4. Domain-general involvement of the posterior frontolateral cortex in time-based resource-sharing in working memory: An fMRI study.

    Science.gov (United States)

    Vergauwe, Evie; Hartstra, Egbert; Barrouillet, Pierre; Brass, Marcel

    2015-07-15

    Working memory is often defined in cognitive psychology as a system devoted to the simultaneous processing and maintenance of information. In line with the time-based resource-sharing model of working memory (TBRS; Barrouillet and Camos, 2015; Barrouillet et al., 2004), there is accumulating evidence that, when memory items have to be maintained while performing a concurrent activity, memory performance depends on the cognitive load of this activity, independently of the domain involved. The present study used fMRI to identify regions in the brain that are sensitive to variations in cognitive load in a domain-general way. More precisely, we aimed at identifying brain areas that activate during maintenance of memory items as a direct function of the cognitive load induced by both verbal and spatial concurrent tasks. Results show that the right IFJ and bilateral SPL/IPS are the only areas showing an increased involvement as cognitive load increases and do so in a domain general manner. When correlating the fMRI signal with the approximated cognitive load as defined by the TBRS model, it was shown that the main focus of the cognitive load-related activation is located in the right IFJ. The present findings indicate that the IFJ makes domain-general contributions to time-based resource-sharing in working memory and allowed us to generate the novel hypothesis by which the IFJ might be the neural basis for the process of rapid switching. We argue that the IFJ might be a crucial part of a central attentional bottleneck in the brain because of its inability to upload more than one task rule at once. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Time Biases in laser ranging measurements; impacts on geodetic products (Reference Frame and Orbitography)

    Science.gov (United States)

    Belli, A.; Exertier, P.; Lemoine, F. G.; Chinn, D. S.; Zelensky, N. P.

    2017-12-01

    The GGOS objectives are to maintain a geodetic network with an accuracy of 1 mm and a stability of 0.1 mm per year. For years, the laser ranging technique, which provide very accurate absolute distances to geodetic targets enable to determine the scale factor as well as coordinates of the geocenter. In order to achieve this goal, systematic errors appearing in the laser ranging measurements must be considered and solved. In addition to Range Bias (RB), which is the primary source of uncertainty of the technique, Time Bias (TB) has been recently detected by using the Time Transfer by Laser Link (T2L2) space instrument capability on-board the satellite Jason-2. Instead of determining TB through the precise orbit determination that is applied to commonly used geodetic targets like LAGEOS to estimate global geodetic products, we have developed, independently, a dedicated method to transfer time between remote satellite laser ranging stations. As a result, the evolving clock phase shift to UTC of around 30 stations has been determined under the form of time series of time bias per station from 2008 to 2016 with an accuracy of 3-4 ns. It demonstrated the difficulty, in terms of Time & Frequency used technologies, to locally maintain accuracy and long term stability at least in the range of 100 ns that is the current requirement for time measurements (UTC) for the laser ranging technique. Because some laser ranging stations oftently exceed this limit (from 100 ns to a few μs) we have been studying these effects first on the precision orbit determination itself, second on the station positioning. We discuss the impact of TB on LAGEOS and Jason-2 orbits, which appears to affect the along-track component essentially. We also investigate the role of TB in global geodetic parameters as the station coordinates. Finally, we propose to provide the community with time series of time bias of laser ranging stations, under the form of a data- handling-file in order to be included in

  6. Restricting access time at pasture and time of grazing allocation for Holstein dairy cows: Ingestive behaviour, dry matter intake and milk production

    NARCIS (Netherlands)

    Mattiauda, D.A.; Tamminga, S.; Gibb, M.J.; Soca, P.; Bentancur, O.; Chilibroste, P.

    2013-01-01

    The objective of this study was to assess the effects of restricting access time to pasture and time of grazing allocation on grazing behaviour, daily dry matter intake (DMI), rumen fermentation, milk production and composition in dairy cows. Twenty-one autumn-calving Holstein cows were assigned to

  7. SMOS near-real-time soil moisture product: processor overview and first validation results

    Directory of Open Access Journals (Sweden)

    N. J. Rodríguez-Fernández

    2017-10-01

    Full Text Available Measurements of the surface soil moisture (SM content are important for a wide range of applications. Among them, operational hydrology and numerical weather prediction, for instance, need SM information in near-real-time (NRT, typically not later than 3 h after sensing. The European Space Agency (ESA Soil Moisture and Ocean Salinity (SMOS satellite is the first mission specifically designed to measure SM from space. The ESA Level 2 SM retrieval algorithm is based on a detailed geophysical modelling and cannot provide SM in NRT. This paper presents the new ESA SMOS NRT SM product. It uses a neural network (NN to provide SM in NRT. The NN inputs are SMOS brightness temperatures for horizontal and vertical polarizations and incidence angles from 30 to 45°. In addition, the NN uses surface soil temperature from the European Centre for Medium-Range Weather Forecasts (ECMWF Integrated Forecast System (IFS. The NN was trained on SMOS Level 2 (L2 SM. The swath of the NRT SM retrieval is somewhat narrower (∼ 915 km than that of the L2 SM dataset (∼ 1150 km, which implies a slightly lower revisit time. The new SMOS NRT SM product was compared to the SMOS Level 2 SM product. The NRT SM data show a standard deviation of the difference with respect to the L2 data of < 0.05 m3 m−3 in most of the Earth and a Pearson correlation coefficient higher than 0.7 in large regions of the globe. The NRT SM dataset does not show a global bias with respect to the L2 dataset but can show local biases of up to 0.05 m3 m−3 in absolute value. The two SMOS SM products were evaluated against in situ measurements of SM from more than 120 sites of the SCAN (Soil Climate Analysis Network and the USCRN (US Climate Reference Network networks in North America. The NRT dataset obtains similar but slightly better results than the L2 data. In summary, the NN SMOS NRT SM product exhibits performances similar to those of the Level 2 SM product

  8. Anesthesia preparation time is not affected by the experience level of the resident involved during his/her first month of adult cardiac surgery.

    Science.gov (United States)

    Broussard, David M; Couch, Michael C

    2011-10-01

    This study was designed to answer the question of whether the experience level of the resident on his/her first month of adult cardiothoracic anesthesiology has an impact on operating room efficiency in a large academic medical center. Traditionally, the resident's 1st month of cardiac anesthesia had been reserved for the clinical anesthesia (CA)-2 year of training. This study analyzed the impact on operating room efficiency of moving the 1st month of cardiac anesthesia into the CA-1 year. The authors hypothesized that there would be no difference in anesthesia preparation times (defined as the interval between "in-room" and "anesthesia-ready" times) between CA-1 and CA-2 residents on their 1st month of cardiac anesthesia. This study was retrospective and used an electronic anesthesia information management system database. This study was conducted on care provided at a single 450-bed academic medical center. This study included 12 residents in their 1st month of cardiac anesthesia. The anesthesia preparation time (defined as the interval between "in-room" and "anesthesia-ready" times) was measured for cases involving residents on their first month of cardiac anesthesia. Anesthesia preparation times for 6 CA-1 resident months and 6 CA-2 resident months (100 adult cardiac procedures in total) were analyzed (49 for the CA-1 residents and 51 for the CA-2s). There were no differences in preparation time between CA-1 and CA-2 residents as a group (p = 0.8169). The CA-1 residents had an unadjusted mean (±standard error) of 51.1 ± 3.18 minutes, whereas the CA-2 residents' unadjusted mean was 50.2 ± 2.41 minutes. Adjusting for case mix (valves v coronary artery bypass graft surgery), the CA-1 mean was 49.1 ± 5.22 minutes, whereas the CA-2 mean was 49.1 ± 4.54 minutes. These findings suggest that operating room efficiency as measured by the anesthesia preparation time may not be affected by the level of the resident on his/her 1st month of adult cardiac anesthesia

  9. Real-Time Data Processing Systems and Products at the Alaska Earthquake Information Center

    Science.gov (United States)

    Ruppert, N. A.; Hansen, R. A.

    2007-05-01

    The Alaska Earthquake Information Center (AEIC) receives data from over 400 seismic sites located within the state boundaries and the surrounding regions and serves as a regional data center. In 2007, the AEIC reported ~20,000 seismic events, with the largest event of M6.6 in Andreanof Islands. The real-time earthquake detection and data processing systems at AEIC are based on the Antelope system from BRTT, Inc. This modular and extensible processing platform allows an integrated system complete from data acquisition to catalog production. Multiple additional modules constructed with the Antelope toolbox have been developed to fit particular needs of the AEIC. The real-time earthquake locations and magnitudes are determined within 2-5 minutes of the event occurrence. AEIC maintains a 24/7 seismologist-on-duty schedule. Earthquake alarms are based on the real- time earthquake detections. Significant events are reviewed by the seismologist on duty within 30 minutes of the occurrence with information releases issued for significant events. This information is disseminated immediately via the AEIC website, ANSS website via QDDS submissions, through e-mail, cell phone and pager notifications, via fax broadcasts and recorded voice-mail messages. In addition, automatic regional moment tensors are determined for events with M>=4.0. This information is posted on the public website. ShakeMaps are being calculated in real-time with the information currently accessible via a password-protected website. AEIC is designing an alarm system targeted for the critical lifeline operations in Alaska. AEIC maintains an extensive computer network to provide adequate support for data processing and archival. For real-time processing, AEIC operates two identical, interoperable computer systems in parallel.

  10. Time course of the involvement of the right anterior superior temporal gyrus and the right fronto-parietal operculum in emotional prosody perception.

    Directory of Open Access Journals (Sweden)

    Marjolijn Hoekert

    Full Text Available In verbal communication, not only the meaning of the words convey information, but also the tone of voice (prosody conveys crucial information about the emotional state and intentions of others. In various studies right frontal and right temporal regions have been found to play a role in emotional prosody perception. Here, we used triple-pulse repetitive transcranial magnetic stimulation (rTMS to shed light on the precise time course of involvement of the right anterior superior temporal gyrus and the right fronto-parietal operculum. We hypothesized that information would be processed in the right anterior superior temporal gyrus before being processed in the right fronto-parietal operculum. Right-handed healthy subjects performed an emotional prosody task. During listening to each sentence a triplet of TMS pulses was applied to one of the regions at one of six time points (400-1900 ms. Results showed a significant main effect of Time for right anterior superior temporal gyrus and right fronto-parietal operculum. The largest interference was observed half-way through the sentence. This effect was stronger for withdrawal emotions than for the approach emotion. A further experiment with the inclusion of an active control condition, TMS over the EEG site POz (midline parietal-occipital junction, revealed stronger effects at the fronto-parietal operculum and anterior superior temporal gyrus relative to the active control condition. No evidence was found for sequential processing of emotional prosodic information from right anterior superior temporal gyrus to the right fronto-parietal operculum, but the results revealed more parallel processing. Our results suggest that both right fronto-parietal operculum and right anterior superior temporal gyrus are critical for emotional prosody perception at a relatively late time period after sentence onset. This may reflect that emotional cues can still be ambiguous at the beginning of sentences, but become

  11. Involvement of adenosine monophosphate-activated protein kinase in the influence of timed high-fat evening diet on the hepatic clock and lipogenic gene expression in mice.

    Science.gov (United States)

    Huang, Yan; Zhu, Zengyan; Xie, Meilin; Xue, Jie

    2015-09-01

    A high-fat diet may result in changes in hepatic clock gene expression, but potential mechanisms are not yet elucidated. Adenosine monophosphate-activated protein kinase (AMPK) is a serine/threonine protein kinase that is recognized as a key regulator of energy metabolism and certain clock genes. Therefore, we hypothesized that AMPK may be involved in the alteration of hepatic clock gene expression under a high-fat environment. This study aimed to examine the effects of timed high-fat evening diet on the activity of hepatic AMPK, clock genes, and lipogenic genes. Mice with hyperlipidemic fatty livers were induced by orally administering high-fat milk via gavage every evening (19:00-20:00) for 6 weeks. Results showed that timed high-fat diet in the evening not only decreased the hepatic AMPK protein expression and activity but also disturbed its circadian rhythm. Accordingly, the hepatic clock genes, including clock, brain-muscle-Arnt-like 1, cryptochrome 2, and period 2, exhibited prominent changes in their expression rhythms and/or amplitudes. The diurnal rhythms of the messenger RNA expression of peroxisome proliferator-activated receptorα, acetyl-CoA carboxylase 1α, and carnitine palmitoyltransferase 1 were also disrupted; the amplitude of peroxisome proliferator-activated receptorγcoactivator 1α was significantly decreased at 3 time points, and fatty liver was observed. These findings demonstrate that timed high-fat diet at night can change hepatic AMPK protein levels, activity, and circadian rhythm, which may subsequently alter the circadian expression of several hepatic clock genes and finally result in the disorder of hepatic lipogenic gene expression and the formation of fatty liver. Copyright © 2015 Elsevier Inc. All rights reserved.

  12. Time course of the involvement of the right anterior superior temporal gyrus and the right fronto-parietal operculum in emotional prosody perception.

    Science.gov (United States)

    Hoekert, Marjolijn; Bais, Leonie; Kahn, René S; Aleman, André

    2008-05-21

    In verbal communication, not only the meaning of the words convey information, but also the tone of voice (prosody) conveys crucial information about the emotional state and intentions of others. In various studies right frontal and right temporal regions have been found to play a role in emotional prosody perception. Here, we used triple-pulse repetitive transcranial magnetic stimulation (rTMS) to shed light on the precise time course of involvement of the right anterior superior temporal gyrus and the right fronto-parietal operculum. We hypothesized that information would be processed in the right anterior superior temporal gyrus before being processed in the right fronto-parietal operculum. Right-handed healthy subjects performed an emotional prosody task. During listening to each sentence a triplet of TMS pulses was applied to one of the regions at one of six time points (400-1900 ms). Results showed a significant main effect of Time for right anterior superior temporal gyrus and right fronto-parietal operculum. The largest interference was observed half-way through the sentence. This effect was stronger for withdrawal emotions than for the approach emotion. A further experiment with the inclusion of an active control condition, TMS over the EEG site POz (midline parietal-occipital junction), revealed stronger effects at the fronto-parietal operculum and anterior superior temporal gyrus relative to the active control condition. No evidence was found for sequential processing of emotional prosodic information from right anterior superior temporal gyrus to the right fronto-parietal operculum, but the results revealed more parallel processing. Our results suggest that both right fronto-parietal operculum and right anterior superior temporal gyrus are critical for emotional prosody perception at a relatively late time period after sentence onset. This may reflect that emotional cues can still be ambiguous at the beginning of sentences, but become more apparent half

  13. RhMKK9, a rose MAP KINASE KINASE gene, is involved in rehydration-triggered ethylene production in rose gynoecia.

    Science.gov (United States)

    Chen, Jiwei; Zhang, Qian; Wang, Qigang; Feng, Ming; Li, Yang; Meng, Yonglu; Zhang, Yi; Liu, Guoqin; Ma, Zhimin; Wu, Hongzhi; Gao, Junping; Ma, Nan

    2017-02-23

    Flower opening is an important process in the life cycle of flowering plants and is influenced by various endogenous and environmental factors. Our previous work demonstrated that rose (Rosa hybrida) flowers are highly sensitive to dehydration during flower opening and the water recovery process after dehydration induced ethylene production rapidly in flower gynoecia. In addition, this temporal- and spatial-specific ethylene production is attributed to a transient but robust activation of the rose MAP KINASE6-ACC SYNTHASE1 (RhMPK6-RhACS1) cascade in gynoecia. However, the upstream component of RhMPK6-RhACS1 is unknown, although RhMKK9 (MAP KINASE KINASE9), a rose homologue of Arabidopsis MKK9, could activate RhMPK6 in vitro. In this study, we monitored RhMKK2/4/5/9 expression, the potential upstream kinase to RhMPK6, in rose gynoecia during dehydration and rehydration. We found only RhMKK9 was rapidly and strongly induced by rehydration. Silencing of RhMKK9 significantly decreased rehydration-triggered ethylene production. Consistently, the expression of several ethylene-responsive genes was down regulated in the petals of RhMKK9-silenced flowers. Moreover, we detected the DNA methylation level in the promoter and gene body of RhMKK9 by Chop-PCR. The results showed that rehydration specifically elevated the DNA methylation level on the RhMKK9 gene body, whereas it resulted in hypomethylation in its promoter. Our results showed that RhMKK9 possibly acts as the upstream component of the RhMKK9-RhMPK6-RhACS1 cascade and is responsible for water recovery-triggered ethylene production in rose gynoecia, and epigenetic DNA methylation is involved in the regulation of RhMKK9 expression by rehydration.

  14. Reservoir characterization using production data and time-lapse seismic data

    Energy Technology Data Exchange (ETDEWEB)

    Dadashpour, Mohsen

    2009-12-15

    The most commonly encountered, and probably the most challenging task in reservoir engineering, is to describe the reservoir accurately and efficiently. An accurate description of a reservoir is crucial to the management of production and efficiency of oil recovery. Reservoir modeling is an important step in a reservoir's future performance, which is in direct proportion to reservoir management, risk analysis and making key economic decisions. The purpose of reservoir modeling is to not only build a model that is consistent with currently available data, but to build one that gives a good prediction of its future behavior. Updating a reservoir model to behave as closely as possible to the real reservoir is called history matching, and the estimation of reservoir properties using this method is known as parameter estimation problem, which is an inversion process. Parameter estimation is a time consuming and non-unique problem with a large solution space. Saturation and pressure changes, and porosity and permeability distributions are the most common parameters to estimate in the oil industry. These parameters must be specified in every node within a petroleum reservoir simulator. These parameters will be adjusted until the model prediction data match the observation data to a sufficient degree. The solution space reduction in this project is done by adding time-lapse seismic data as a new set of dynamic data to the traditional production histories. Time-lapse (or 4D) seismic consists of two or more 3D seismic surveys shot at different calendar times. Time-lapse seismic surveys produce images at different times in a reservoir's history. The seismic response of a reservoir may change due to changes in pressure, fluid saturation and temperature. These changes in seismic images due to a variation in saturation and pressure can be used as additional observation data. Time-lapse seismic data are dynamical measurements which have a high resolution in the

  15. Production of the 2400 kb Duchenne muscular dystrophy (DMD) gene transcript; transcription time and cotranscriptional splicing

    Energy Technology Data Exchange (ETDEWEB)

    Tennyson, C.N.; Worton, R.G. [Univ. of Toronto and the Hospital for Sick Children, Ontario (Canada)

    1994-09-01

    The largest known gene in any organism is the human DMD gene which has 79 exons that span 2400 kb. The extreme nature of the DMD gene raises questions concerning the time required for transcription and whether splicing begins before transcription is complete. DMD gene transcription is induced as cultured human myoblasts differentiate to form multinucleated myotubes, providing a system for studying the kinetics of transcription and splicing. Using quantitative RT-PCR, transcript accumulation was monitored from four different regions within the gene following induction of expression. By comparing the accumulation of transcripts from the 5{prime} and 3{prime} ends of the gene we have shown that approximately 12 hours are required to transcribe 1770 kb of the gene, extrapolating to a time of 16 hours for the transcription unit expressed in muscle. Comparison of accumulation profiles for spliced and total transcript demonstrated that transcripts are spliced at the 5{prime} end before transcription is complete, providing strong evidence for cotranscriptional splicing of DMD gene transcripts. Finally, the rate of transcript accumulation was reduced at the 3{prime} end of the gene relative to the 5{prime} end, perhaps due to premature termination of transcription complexes as they traverse this enormous transcription unit. The lag between transcription initiation and the appearance of complete transcripts could be important in limiting transcript production in dividing cells and to the timing of mRNA appearance in differentiating muscle.

  16. CARBON CRYOGEL MICROSPHERE FOR ETHYL LEVULINATE PRODUCTION: EFFECT OF CARBONIZATION TEMPERATURE AND TIME

    Directory of Open Access Journals (Sweden)

    MUZAKKIR M. ZAINOL

    2016-07-01

    Full Text Available The side products of biomass and bio-fuel industry have shown potential in producing carbon catalyst. The carbon cryogel was synthesized from ligninfurfural mixture based on the following details: 1.0 of lignin to furfural (L/F ratio, 1.0 of lignin to water (L/W ratio, and 8M of acid concentration. The lignin-furfural sol-gel mixture, initially prepared via polycondensation reaction at 90 °C for 30 min, was followed by freeze drying and carbonization process. Effects of carbonization temperature and time were investigated on the total acidity and surface area of the carbon cryogel. Furthermore, the effects of these parameters were studied on the ethyl levulinate yield through esterification reaction of levulinic acid in ethanol. The esterification reaction was conducted at reflux temperature, 10 h of reaction time, 19 molar ratio of ethanol to levulinic acid, and 15.0 wt.% carbon cryogel loading. Based on the carbonization temperature and time studies, the carbon cryogel carbonized at 500 °C and 4 h exhibited good performance as solid acid catalyst. Large total surface area and acidity significantly influenced the catalytic activity of carbon cryogel with 80.0 wt.% yield of ethyl levulinate. Thus, carbon cryogel is highly potential as acid catalyst for the esterification of levulinic acid with ethanol.

  17. Technology for Intensive Poultry Production as a Source of Odour Emissions with Time-Varying Intensity

    Directory of Open Access Journals (Sweden)

    Kuneš Radim

    2017-12-01

    Full Text Available The technology for intensive broiler breeding using deep litter method provides convenient conditions for production of odour substances inside the barn. As a consequence, there are relatively high odour emissions in the breeding area and its surrounding, which has significant impacts on the life quality of both people and animals. The amount of produced emissions increases in time because it is closely related to the amount of poultry droppings accumulated in litter inside the barn. This paper deals with changes in odour intensity depending on time measured since the beginning of broiler fattening. Odour intensity was measured by methods of dynamic olfactometry. The estimated values gradually increased from 45 ouE·m-3 to the highest value of 259 ouE·m-3, which was determined in the final fattening phase (broilers’ age 33 days. The calculated odour substances emission values were in range from 0.02 ouE·s-1·bird-1 at the beginning of fattening up to 0.10 ouE·s-1·bird-1 in the final fattening phase. Odour emissions increased five times during the fattening period.

  18. Near-extreme system condition and near-extreme remaining useful time for a group of products

    International Nuclear Information System (INIS)

    Wang, Hai-Kun; Li, Yan-Feng; Huang, Hong-Zhong; Jin, Tongdan

    2017-01-01

    When a group of identical products is operating in field, the aggregation of failures is a catastrophe to engineers and customers who strive to develop reliable and safe products. In order to avoid a swarm of failures in a short time, it is essential to measure the degree of dispersion from different failure times in a group of products to the first failure time. This phenomenon is relevant to the crowding of system conditions near the worst one among a group of products. The group size in this paper represents a finite number of products, instead of infinite number or a single product. We evaluate the reliability of the product fleet from two aspects. First, we define near-extreme system condition and near-extreme failure time for offline solutions, which means no online observations. Second, we apply them to a continuous degradation system that breaks down when it reaches a soft failure threshold. By using particle filtering in the framework of prognostics and health management for a group of products, we aim to estimate near-extreme system condition and further predict the remaining useful life (RUL) using online solutions. Numerical examples are provided to demonstrate the effectiveness of the proposed method. - Highlights: • The aggregation of failures is measured for a group of identical products. • The crowding of failures is quantitated by the near-extreme evaluations. • Near-extreme system condition are given for offline solutions. • Near-extreme remaining useful time are provided for online solutions.

  19. Recent Advances in the Study of Marine Microbial Biofilm: From the Involvement of Quorum Sensing in Its Production up to Biotechnological Application of the Polysaccharide Fractions

    Directory of Open Access Journals (Sweden)

    Paola Di Donato

    2016-05-01

    Full Text Available The present review will explore the most relevant findings on marine microbial biofilm, with particular attention towards its polysaccharide fraction, namely exopolysaccharide (EPS. EPSs of microbial origin are ubiquitous in nature, possess unique properties and can be isolated from the bacteria living in a variety of habitats, including fresh water or marine environments, extreme environments or different soil ecosystems. These biopolymers have many application in the field of biotechnology. Several studies showed that the biofilm formation is closely related to quorum sensing (QS systems, which is a mechanism relying on the production of small molecules defined as “autoinducers” that bacteria release in the surrounding environment where they accumulate. In this review, the involvement of microbial chemical communication, by QS mechanism, in the formation of marine biofilm will also be discussed.

  20. A Drosophila Genome-Wide Screen Identifies Regulators of Steroid Hormone Production and Developmental Timing

    DEFF Research Database (Denmark)

    Thomas Danielsen, E.; E. Møller, Morten; Yamanaka, Naoki

    2016-01-01

    Steroid hormones control important developmental processes and are linked to many diseases. To systematically identify genes and pathways required for steroid production, we performed a Drosophila genome-wide in vivo RNAi screen and identified 1,906 genes with potential roles in steroidogenesis...... and developmental timing. Here, we use our screen as a resource to identify mechanisms regulating intracellular levels of cholesterol, a substrate for steroidogenesis. We identify a conserved fatty acid elongase that underlies a mechanism that adjusts cholesterol trafficking and steroidogenesis with nutrition...... and developmental programs. In addition, we demonstrate the existence of an autophagosomal cholesterol mobilization mechanism and show that activation of this system rescues Niemann-Pick type C1 deficiency that causes a disorder characterized by cholesterol accumulation. These cholesterol-trafficking mechanisms...