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  1. Erythroblastopénie induite par la grossesse: à propos d'un cas et ...

    African Journals Online (AJOL)

    Erythroblastopénie induite par la grossesse: à propos d'un cas et revue de la littérature. Drissi Jihad, Kouach Jaouad, Moussaoui Driss, Dehayni Mohamed. Abstract. L'érythroblastopénie induite par la grossesse est une entité pathologique exceptionnelle dont seuls quelques cas isolés ont été décrits dans la littérature ...

  2. Approche numérique de la plasticité induite par transformation ...

    African Journals Online (AJOL)

    H. Hoang et al. 80. Approche numérique de la plasticité induite par transformation diffusionnelle : investigations dans le cas de l'interaction plasticité classique TRIP. Ha Hoang ... d'une phase parente pré-écrouie, d'après ce qu'ont montré Taleb et Petit-Grostabussiat. Ceci a ...... Transformations in Ferrous Alloys : Some.

  3. Priapisme induit par la chlorpromazine: A propos de deux cas

    African Journals Online (AJOL)

    I. Marrag

    stratégies thérapeutiques par les cliniciens permet de préserver la vie sexuelle des patients, souvent touchée par la prescription des traitements psychotropes. Consentement. Le consentement des patients etait demande et approuve. Assentiment du comité d'étique. La comité d'éthique a approuvé ce travail sans qu'il est ...

  4. Priapisme induit par la chlorpromazine: A propos de deux cas

    Directory of Open Access Journals (Sweden)

    I. Marrag

    2016-06-01

    Le priapisme veineux est une urgence urologique. Il constitue un des effets secondaires des neuroleptiques parmi les quels la chlorpromazine. Cet effet iatrogène, qui est rare mais grave, doit être connu par les cliniciens afin d’être mieux prévenu pour éviter les séquelles érectiles.

  5. Erythroblastopénie induite par la grossesse: à propos d'un cas et revue de la literature

    Science.gov (United States)

    Jihad, Drissi; Jaouad, Kouach; Driss, Moussaoui; Mohamed, Dehayni

    2016-01-01

    L’érythroblastopénie induite par la grossesse est une entité pathologique exceptionnelle dont seuls quelques cas isolés ont été décrits dans la littérature anglaise. L'objectif de ce travail est d'analyser les caractéristiques de cette pathologie extrêmement rare à travers la description d'un nouveau cas d’érythroblastopénie induite par la grossesse, et à travers l’étude des 17 cas antérieurement rapportés. PMID:27642487

  6. Encuesta de parásitos intestinales en 615 escolares del Rímac

    Directory of Open Access Journals (Sweden)

    Luis Gonzales-Mugaburu

    1956-12-01

    Full Text Available El examen microscópico de una sola muestra de heces de cada uno de 615 escolares del Rímac, ha mostrado: 1. El elevado porcentaje de protozoarios intestinales encontrados, sugiere una alta contaminación fecal. 2. La alta frecuencia de H. nana 166 (27.0% constituye un problema al que hay que prestar atención. 3. El hallazgo de Strongyloides stercoralis y Ancylostoma o Necator sólo en sujetos que habían estado algún tiempo en la Selva del Perú, sugiere una vez más, que dichos parásitos no son transmitidos en esta parte de la Costa. 4. La presencia de tres casos de Isospora belli nos indica que esta coccidia es más frecuente de lo que se suponía.

  7. Approche numérique de la plasticité induite par transformation ...

    African Journals Online (AJOL)

    ﺔﯿﮭﺘﻨﻣ ﺮﺻﺎﻨﻋ ؛يرﺎﺸﺘﻧا لﻮﺤﺗ ؛ﻲﻜﯿﻧﺎﻜﯿﻣوﺮﻜﯿﻣ ﻞﯿﻜﺸﺗ ؛ﺾﯾﺮﺤﺘﻟﺎﺑ ﺔﻧاﺪ . Résumé. Le phénomène mécanique appelé TRIP (Transformation Induced Plasticity), correspondant à une déformation permanente induite par une transformation de phase, peut apparaître lors d'une transformation sous chargement extérieur comme lorsque la phase ...

  8. Douleurs induites par les soins: la réalité au Centre Hospitalier Universitaire de Befelatanana Antananarivo, Madagascar

    Science.gov (United States)

    Mahavivola, Ernestho-Ghoud Indretsy; Olivah, Razanaparany Miarisoa Mireille; Mihary, Dodo; Hendriniaina, Rakotoharivelo; Lalao, Randriamboavonjy Rado; Henintsoa, Rakotonirainy Oliva; Fahafahantsoa, Rapelanoro Rabenja

    2014-01-01

    La douleur induite par les soins correspond à la douleur survenant lors des actes à visé diagnostique et/ou thérapeutique. A notre connaissance, nous n'avons pas encore des données disponibles pour les douleurs induites par les soins à l'Hôpital de Befelatanana. Nos objectifs étaient de décrire le profil épidémiologique de la douleur induite par les soins, d'identifier les principaux facteurs influençant sur l'intensité de la douleur et leurs retentissements chez les patients. Il s'agissait d'une étude rétrospective, transversale type un jour donné menée dans les douze services de Médecines au Centre Hospitalier Universitaire de Befelatanana en Novembre 2013. Cent deux patients ont été retenus dans l’étude et trois cent vingt trois actes douloureux étaient enregistrés. La fréquence de la douleur induite par les soins était de 69,86%. Le genre féminin prédominait dans 52% des cas (n = 53) avec un sex-ratio à 0,92. L’âge moyen était de 46 ans. Les ponctions vasculaires étaient l'acte prédominant dans 49,54% (n = 109) des cas. Les infirmiers réalisaient les soins dans 47,05% (n = 48) des cas. L'information verbale était la mesure préventive utilisée dans 57,84% des cas (n = 59). Le transport par marche à pied et au dos représentait 16,67% des cas (n = 17). Les patients naïfs des gestes étaient plus anxieux. Ces patients gardaient de mauvais souvenir dans 64,71% des cas (n = 66). La fréquence de douleur induite par les soins était trop élevée. Un effort important est nécessaire pour réduire la douleur induite par les soins PMID:25932071

  9. Detección de parásitos intestinales en agua y alimentos de Trujillo, Perú

    OpenAIRE

    Gregorio Pérez-Cordón; María J. Rosales; Renzo A. Valdez; Franklin Vargas-Vásquez; Ofelia Cordova

    2008-01-01

    Detectamos distintas especies de parásitos intestinales, tanto protozoos como helmintos, presentes en muestras de agua provenientes de acequias y pozos (Giardia lamblia, Blastocystis hominis, Entamoeba coli, Cyclospora cayetanensis, Cryptosporidium spp. y Balantidium coli), así como en alimentos crudos y cocidos (Giardia lamblia, Cyclospora cayetanensis., Endolimax nana, Iodamoeba butschlii y Blastocystis hominis Fasciola hepatica y Ascaris lumbricoides) recolectadas en varios distritos de la...

  10. Detección de parásitos intestinales en agua y alimentos de Trujillo, Perú

    Directory of Open Access Journals (Sweden)

    Gregorio Pérez-Cordón

    2008-01-01

    Full Text Available Detectamos distintas especies de parásitos intestinales, tanto protozoos como helmintos, presentes en muestras de agua provenientes de acequias y pozos (Giardia lamblia, Blastocystis hominis, Entamoeba coli, Cyclospora cayetanensis, Cryptosporidium spp. y Balantidium coli, así como en alimentos crudos y cocidos (Giardia lamblia, Cyclospora cayetanensis., Endolimax nana, Iodamoeba butschlii y Blastocystis hominis Fasciola hepatica y Ascaris lumbricoides recolectadas en varios distritos de la provincia de Trujillo, Perú.

  11. Prevalencia de microsporidios y otros parásitos intestinales en pacientes con infección por VIH, Bogotá, 2001.

    OpenAIRE

    Astrid Carolina Flórez; Dabeiba Adriana García; Ligia Moncada; Mauricio Beltrán

    2003-01-01

    Los parásitos intestinales oportunistas son protozoos que causan diarrea en pacientes infectados con el virus de inmunodeficiencia humana (VIH). Para determinar la prevalencia de microsporidios y otros parásitos oportunistas intestinales en pacientes infectados con el VIH con síntomas gastrointestinales y sistémicos, se estudiaron 115 pacientes que durante el 2001 consultaron al Hospital Santa Clara (33,0%), Clínica San Pedro-ISS (20,0%), Hospital Simón Bolívar (14,8%), San José (13,9%), Cent...

  12. Protection des ions organiques contre les dommages induits a l'ADN par les electrons de basse energie

    Science.gov (United States)

    Dumont, Ariane

    Il a ete demontre que les electrons de basse energie (EBE) peuvent induire des cassures simple brin (CSB) a l'ADN, via la formation d'anions transitoires qui decroissent par attachement dissociatif, ou dans d'autres etats electroniques dissociatifs menant a la fragmentation. Afin d'effectuer une etude complete des effets des electrons de basse energie sur la matiere biologique, il est necessaire de comprendre leur mecanismes d'interaction non seulement avec l'ADN, mais avec les constituants de son environnement. Les histones sont une composante importante de l'environnement moleculaire de l'ADN. Leur charge positive leur permet de s'associer aux groupements phosphate anionique de l'ADN. Le role principal de ces proteines basiques consiste a organiser l'ADN et l'empaqueter afin de former la chromatine. Les cations sont une autre composante importante de la cellule; ils jouent un role dans la stabilisation de la conformation B de l'ADN in vitro par leurs interactions avec les petits et grands sillons de l'ADN, ainsi qu'avec le groupement phosphate charge negativement. Avec les histones, ils participent egalement a la compaction de l'ADN pour former la chromatine. Cette etude a pour but de comprendre comment la presence d'ions organiques (sous forme de Tris et d'EDTA) a proximite de l'ADN modifie le rendement de cassures simple brin induit par les electrons de basse energie. Le Tris et l'EDTA ont-ete choisis comme objet d'etude, puisqu'en solution, ils forment le tampon standard pour solubiliser l'ADN dans les experiences in vitro (10mM Tris, 1mM EDTA). De plus, la molecule Tris possede un groupement amine alors que l'EDTA possede 4 groupements carboxyliques. Ensembles, ils peuvent se comporter comme un modele simple pour les acides amines. Le ratio molaire de 10 :1 de Tris par rapport a l'EDTA a pour but d'imiter le comportement des histones qui sont riches en arginine et lysine, acides amines possedant un groupement amine charge positivement additionnel. Des films d

  13. Parásitos intestinales, desnutrición y condiciones de vida de niños en Urabá (Colombia): soledad y olvido

    OpenAIRE

    Jaime Carmona-Fonseca; Adriana Correa-Botero

    2013-01-01

    AntecedentesLas parasitosis intestinales y el hambre y la desnutrición son manifestación de las desigualdades prevalecientes en salud, determinadas por inequidad social, económica y política. Estos problemas de salud pública tienen elevada frecuencia mundial y poco se hace por resolverlos, a pesar de existir los conocimientos y herramientas científico-tecnológicos para hacerlo.ObjetivoMedir las prevalencias de desnutrición y parásitos intestinales patógenos en niños del Urabá Antioqueño, en C...

  14. El sentido de las enfermedades por parásitos intestinales en poblaciones americanas, identificando dilemas bioéticos

    Directory of Open Access Journals (Sweden)

    María del Pilar Díaz Murillo

    2013-01-01

    Full Text Available Objetivo: Identificar sentidos que pueblos del continente americano le asignan a las parasitosis intestinales y plantear posibles conflictos o dilemas en las tomas de decisiones en diferentes actividades de salud producto del encuentro de valores distintos, campo de acción de la bioética. Metodología: Revisión bibliográfica de artículos sobre parasitosis intestinales que cumplieran los criterios de inclusión establecidos y suministraran aportes para la comprensión hermenéutica de las parasitosis intestinales y permitieran identificar dilemas bioéticos para actividades en salud resultantes del contacto entre las visiones émica y ética (de la biomedicina. Resultados: La construcción social de las parasitosis intestinales influye en su percepción de causalidad, nocividad y como problema de salud, lo cual afecta las acciones que la gente emprenda ante ellas. Se advierte que tales construcciones sociales pueden no coincidir con la perspectiva biomédica. Se observó que en algunas poblaciones la construcción social del cuerpo se relaciona con la percepción de efectos benéficos de los parásitos. La gente reconoce factores de riesgo pero esto no necesariamente conduce a comportamientos preventivos. Algunos estudios reconocen que la educación ha sido de tipo informativo, sin participación comunitaria, lo cual impide que la gente se identifique con ella y se sienta motivada a transformar su realidad. Se identificaron diversos dilemas bioéticos producto del contacto entre visiones de las poblaciones, y la biomedicina. Conclusiones: La aproximación émica permite entender la lógica de la población sobre las parasitosis intestinales e identificar disyuntivas bioéticas. Aunque la gente reconozca los riesgos de infección, la falta de comprensión de la perspectiva émica de los parasitismos por parte del personal de salud y las deficientes condiciones de vida permiten que no se produzcan transformaciones que incidan en la disminuci

  15. Réponse au stress induit par le transport chez la truite arc-en-ciel (Oncorhynchus mykiss

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    ROUGER Y.

    1998-07-01

    Full Text Available La réponse au stress induit par le transport a été étudiée chez des truites arc-en-ciel immatures d'un poids moyen de 200 g. D'une manière globale, les valeurs de l'hématocrite, de l'osmolarité du plasma sanguin, du Cortisol et de la testostérone sont significativement plus élevées chez les poissons transportés que chez les témoins non transportés, alors que les niveaux de gonadostimuline (GTH1 et d'hormone de croissance ne diffèrent pas suivant les lots. L'analyse du comportement en "open field" des individus de chaque lot montre que les poissons transportés s'immobilisent en moyenne après un temps significativement plus long que les témoins. L'étude des performances zootechniques de chaque lot pendant les deux mois suivant l'expérience indique que le lot transporté récupère rapidement.

  16. Une occlusion intestinale aiguë par un os de poulet | Mahmoudi ...

    African Journals Online (AJOL)

    L'ingestion de corps étranger (CE) peut causer de multiples complications parfois graves. Il s'agit le plus souvent d'un accident survenant chez des enfants, parfois chez des malades psychiatriques. Chez les adultes, l'accident est favorisé par des mauvaises habitudes alimentaires (repas trop rapide, quintes de toux ou ...

  17. El sentido de las enfermedades por parásitos intestinales en poblaciones americanas, identificando dilemas bioéticos

    OpenAIRE

    María del Pilar Díaz Murillo; Nohora Aidée Ramírez Sánchez; Samuel David Osorio García

    2013-01-01

    Objetivo: Identificar sentidos que pueblos del continente americano le asignan a las parasitosis intestinales y plantear posibles conflictos o dilemas en las tomas de decisiones en diferentes actividades de salud producto del encuentro de valores distintos, campo de acción de la bioética. Metodología: Revisión bibliográfica de artículos sobre parasitosis intestinales que cumplieran los criterios de inclusión establecidos y suministraran aportes para la comprensión hermenéutica de las parasito...

  18. Prevalencia de microsporidios y otros parásitos intestinales en pacientes con infección por VIH, Bogotá, 2001.

    Directory of Open Access Journals (Sweden)

    Astrid Carolina Flórez

    2003-09-01

    Full Text Available Los parásitos intestinales oportunistas son protozoos que causan diarrea en pacientes infectados con el virus de inmunodeficiencia humana (VIH. Para determinar la prevalencia de microsporidios y otros parásitos oportunistas intestinales en pacientes infectados con el VIH con síntomas gastrointestinales y sistémicos, se estudiaron 115 pacientes que durante el 2001 consultaron al Hospital Santa Clara (33,0%, Clínica San Pedro-ISS (20,0%, Hospital Simón Bolívar (14,8%, San José (13,9%, Central de la Policía (6,1%, Compensar (5,2%, Liga de Lucha contra el Sida (2,6%, Hospital San Ignacio (2,6% y Hospital Militar (1,7%. La edad promedio fue de 36 años con un rango de 18 a 71 años; 14 eran mujeres y 101 hombres. La metodología empleada fue la recolección por paciente de dos muestras de materia fecal seriadas para montaje directo, concentración, coloración de Zielh Neelsen modificada para diagnóstico de coccidios intestinales y coloraciones de cromotropo modificada, Gramcromotropo y calcoflúor para diagnóstico de microsporidios. La prevalencia de oportunistas fue de 10,4 % para Cryptosporidium sp. En cuanto a microsporidios, se encontró que de 29% de positividad con cromotropo modificada como tamizaje, tan sólo 3,5% de las muestras se confirmaron como positivas con técnicas de calcoflúor y Gram-cromotropo. La prevalencia general de parásitos intestinales fue de 59,1%, de los cuales los principales patógenos fueron Blastocystis hominis con 25,2% y Entamoeba histolytica con 13%. En otros estudios con pacientes inmunosuprimidos por el VIH en Colombia, se han encontrado prevalencias de Cryptosporidium sp. menores que la hallada en esta investigación.

  19. Parásitos intestinales en monos congo Alouatta palliata (Primates: Cebidae de Costa Rica

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    Misael Chinchilla Carmona

    2005-09-01

    Full Text Available Se estudiaron las heces de 102 monos de la especie Alouatta palliata (monos aulladores o congos de las siguientes regiones de Costa Rica. Valle Central: San Ramón (Alajuela; Pacífico Central: Isla Chira y Parque Manuel Antonio (Puntarenas; Pacífico Norte: Palo Verde, Playa Potrero, Nicoya (Guanacaste y Caribe: Cahuita (Limón. Los animales capturados fueron anestesiados con dardos conteniendo Telazol®. La mayoría defecaron espontáneamente o se les estimulaba a defecar. Las muestras se estudiaron en el laboratorio en forma directa en solución salina (0.85% y una solución de yodo o teñidas con hematoxilina para identificar los parásitos correspondientes. El material fue cultivado en el medio de Dobell para determinar la presencia de amebas y flagelados. Se encontraron helmintos de los géneros Trypanoxyuris, Strongyloides y Controrchis y protozoarios de los géneros Endolimax, Entamoeba, Trichomonas y Giardia. Los porcentajes de infección por protozoarios oscilaron entre 16.7% y 80% y se encontraron helmintos en un 3.4% a un 80% de los animales de acuerdo con la zona estudiada. No se encontraron diferencias importantes de parasitosis relacionadas con el sexo pero si existió mayor infección en los animales más jóvenes. Se establece la relación entre los índices de infección y algunos parámetros tales como las áreas estudiadas, el peso de los animales y el contacto con el ser humano.Intestinal parasites in howler monkeys Alouatta palliata (Primates: Cebidae of Costa Rica. Fecal samples of 102 howler monkeys (Alouatta palliata from several sites of Costa Rica were studied for intestinal parasites. The zones studied were: Central Valley (San Ramón, Alajuela, Central Pacific (Chomes and Manuel Antonio National Park, Puntarenas, North Pacific (Palo Verde Park and Playa Potrero, Guanacaste, Chira Island in the Nicoya Gulf and Caribean area (Cahuita, Limón. Animals were anesthetized with dards containing Telazol in order to collect

  20. Stress-Induced Seismic Anisotropy Revisited Nouveau regard sur l'anisotropie sismique induite par les contraintes

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    Rasolofosaon P.

    2006-12-01

    S-wave polarized in the coordinate planes. The nearly exhaustive collection of experimental data on seismic anisotropy in rocks (considered as transverse isotropic by Thomsen (1986 show that elliptical anisotropy is more an exception than a rule. Since stress-induced anisotropy is essentially elliptical when restricted to transversely isotropic media, as a consequence this work clearly shows that stress can be practically excluded as a unique direct cause of elastic anisotropy in rocks. Ce résumé contient des formules (*** qui ne peuvent s'afficher à l'écran Un principe général esquissé par P. Curie (1894 concernant l'influence de la symétrie sur les phénomènes physiques dit, en langage actuel, que le groupe de symétrie des causes est un sous-groupe du groupe de symétrie des effets. Par exemple, en ce qui concerne l'anisotropie sismique induite par les contraintes, la symétrie la plus complexe présentée par un milieu initialement isotrope, sous contrainte triaxiale, est orthorhombique ou orthotrope, caractérisée par trois plans de symétrie orthogonaux deux à deux (Nur, 1971. À d'autres égards, Schwartz et al. (1994 ont montré que deux modèles de roches très différents, un modèle fissuré et un modèle granulaire faiblement consolidé, conduisent toujours à une anisotropie elliptique quand ils sont soumis à une contrainte uniaxiale. La question posée est la suivante : est-ce que ce résultat est vrai pour tous les modèles de roches ? et, plus généralement, est-ce que les roches initialement isotropes, quand elles sont soumises à une contrainte triaxiale, forment un sous-ensemble bien défini des milieux orthorhombiques ? Sous l'hypothèse d'hyperélasticité isotrope non linéaire du troisième ordre (c'est-à-dire absence d'hystérésis, et existence d'une fonction d'énergie élastique développée au troisième ordre dans les composantes de la déformation, il est démontré que l'anisotropie de l'onde qP induite par les contraintes est toujours

  1. Parásitos intestinales, desnutrición y condiciones de vida de niños en Urabá (Colombia: soledad y olvido

    Directory of Open Access Journals (Sweden)

    Jaime Carmona-Fonseca

    2013-12-01

    Full Text Available AntecedentesLas parasitosis intestinales y el hambre y la desnutrición son manifestación de las desigualdades prevalecientes en salud, determinadas por inequidad social, económica y política. Estos problemas de salud pública tienen elevada frecuencia mundial y poco se hace por resolverlos, a pesar de existir los conocimientos y herramientas científico-tecnológicos para hacerlo.ObjetivoMedir las prevalencias de desnutrición y parásitos intestinales patógenos en niños del Urabá Antioqueño, en Colombia, y analizarlas según las condiciones de vida imperantes.MetodologíaEl estudio se hizo en Turbo (Urabá, en menores de 15 años, con diseño descriptivo prospectivo (encuesta de prevalencia. Los niños se captaron en sus casas o escuelas. Se hicieron exámenes coprológico, hemograma, ferritina, retinol, proteína C reactiva.ResultadosSe evaluaron 1600 niños y hallamos: desnutrición crónica en 25%; hemoglobina menor de 11 g/dL en 45%; ferritina y retinol bajos en 20% y 26%, respectivamente; parásitos intestinales patógenos en 87%.ConclusionesLos hallazgos, analizados en función de información disponible, revelan peor situación sanitaria y social de los niños y familias de Urabá, comparada con el panorama general de Antioquia. Desnutrición, anemia y deficiencias de hierro y vitamina A están presentes en una proporción muy alta. Parásitos, hambre y desnutrición coexisten en los menores de 15 años de Urabá. Las condiciones de vida vigente en Urabá generan y mantienen las condiciones descritas, al tiempo que impiden mejorarlas y resolver los problemas.

  2. Characterization and pharmacological modulation of intestinal inflammation induced by ionizing radiation; Caracterisation et modulation pharmacologique de l'inflammation intestinale induite par les rayonnements ionisants

    Energy Technology Data Exchange (ETDEWEB)

    Gremy, O

    2006-12-15

    The use of radiation therapy to treat abdominal and pelvic malignancies inevitably involves exposure of healthy intestinal tissues which are very radiosensitive. As a result, most patients experience symptoms such as abdominal pain, nausea and diarrhea. Such symptoms are associated with acute damage to intestine mucosa including radio-induced inflammatory processes. With a rat model of colorectal fractionated radiation, we have shown a gradual development of a colonic inflammation during radiation planning, without evident tissue injury. This radio-induced inflammation is characterized not only by the sur expressions of pro-inflammatory cytokines and chemokines, a NF-kB activation, but also by a repression of anti-inflammatory cytokines and the nuclear receptors PPARa and RXRa, both involved in inflammation control. This early inflammation is associated with a discreet neutrophil recruitment and a macrophage accumulation. Macrophages are still abnormally numerous in tissue 27 weeks after the last day of irradiation. Inflammatory process is the most often related to a specific immune profile, either a type Th1 leading to a cellular immune response, or a type Th2 for humoral immunity. According to our studies, a unique abdominal radiation in the rat induces an ileum inflammation and an immune imbalance resulting in a Th2-type profile. Inhibiting this profile is important as its persistence promotes chronic inflammation, predisposition to bacterial infections and fibrosis which is the main delayed side-effect of radiotherapy. The treatment of rats with an immuno-modulator compound, the caffeic acid phenethyl ester (C.A.P.E.), have the potential to both reduce ileal mucosal inflammation and inhibit the radio-induced Th2 status. In order to search new therapeutic molecular target, we has been interested in the PPARg nuclear receptor involved in the maintenance of colon mucosal integrity. In our abdominal irradiation model, we have demonstrated that the prophylactic treatment with a PPARg synthetic ligand, the so-called 5-aminosalicylic acid (5-ASA), protects against the development of the acute mucosal colon inflammation. This pharmacological drug restrains radio-induced expression of pro inflammatory molecular actors such as TNFa, MCP-1 and iNOS, it also limits the repression of nuclear receptors involved in inflammation control such as PPARg, and reduces the radio-induced accumulation of macrophages. These results could give some leads to find therapeutic drug to limit radio-induced early mucosal and consequently, to improve patients' comfort during and after the radiotherapy schedule. (author)

  3. Etiologies et pronostic des occlusions intestinales aigues ...

    African Journals Online (AJOL)

    Celle-ci était corrélée statistiquement à la nécrose intestinale (p=0,01) et au retard d'admission (p=0,04). Les étiologies des OIA sont multiples et dominées par les hernies étranglées. La morbi-mortalité élevée qu'elles entrainent pourrait être évitée par la prise en charge précoce avant l'installation d'une nécrose intestinale ...

  4. Presencia de parásitos intestinales en muestras de heces de empleados administrativos de una universidad privada.

    OpenAIRE

    Avelar, Verónica María; Santos Herrera, René Guillermo

    2014-01-01

    El presente trabajo consistió, en la recolección y análisis parasitológico de las muestras de heces provenientes de los empleados del área administrativa de una universidad privada durante el mes de septiembre del 2013. Las muestras fueron identificadas por edad,fecha,lugar de residencia y área de trabajo al que pertenece cada uno de los empleados.Todos los participantes dieron su aval de ser incluidos en el estudio a través de la firma de consentimiento informado.La metodología utilizada par...

  5. Alimentation animale et valeur nutritionnelle induite sur les produits dérivés consommés par l’homme : Les lipides sont-ils principalement concernés ?

    Directory of Open Access Journals (Sweden)

    Bourre Jean-Marie

    2003-09-01

    Full Text Available Dans quelle mesure la nourriture reçue par les animaux induit-elle une modification (amélioration ou au contraire dégradation de la valeur nutritionnelle des aliments qui en sont issus pour la nourriture de l’homme ? La réponse à cette question varie selon la nature des nutriments (vitamines, minéraux, acides gras poly-insaturés indispensables des graisses, acides aminés indispensables des protéines, et aussi de l’espèce considérée. Le problème est de rechercher l’impact réel des formulations des rations utilisées dans les élevages sur la valeur nutritionnelle des produits (viandes, lait et laitages, fromages et œufs, etc., et donc leur influence sur la santé du consommateur, évidemment dans un sens favorable. Les acides gras poly-insaturés oméga-3 (ω3 bénéficient de deux grands axes de valorisation. Le premier réside dans leur importance quantitative et leurs rôles dans le cadre de la mise en place et du maintien de divers organes, le cerveau au premier chef. Le second se trouve dans la prévention de diverses pathologies, les maladies cardio-vasculaires occupant une place prépondérante \\; avec, depuis peu, les maladies neuro-psychiatriques, stress, dépression et démence. Compte tenu des implications en termes de maladies, cardio-cérébro-vasculaires entre autres, le contrôle de la nature des acides gras constitutifs des graisses représente donc un enjeu considérable en ce qui concerne les viandes issues d’animaux terrestres, maritimes et aériens, du lait, des laitages, fromages et des œufs. Car la qualité des graisses données en nourriture animale détermine fondamentalement la valeur nutritionnelle des aliments qui en sont dérivés, pour la consommation humaine. Bien évidemment, il est relativement difficile de modifier la composition en acides gras des phospholipides constitutifs des membranes biologiques intégrées dans la multitude de types cellulaires, dont la spécificité est largement

  6. ETUDE DE L'EFFET DE QUELQUES FACTEURS SUR LA CYTOTOXICITE INDUITE PAR L'AMPHOTERICINE B ASSOCIEE AUX LIPOPROTEINES DU SERUM SANGUIN CHEZ DES CELLULES DE GLOBULES ROUGES HUMAINES

    OpenAIRE

    BOUCHERIT, ATMANI Zahia

    2014-01-01

    toxiques. Dans le cadre de l'élaboration d'une stratégie de développement de cette molécule visant à augmenter l'index thérapeutique tout en réduisant la toxicité, nous avons étudié l'effet de quelques facteurs sur la cytotoxicité induite par l'amphotéricine B associée à des lipoprotéines du sérum sanguin chez le globule rouge humain (modèle universel de cellules animales supérieures). Dans notre travail nous avons abordé d'une part, les effets des caractéristiques des lipoprot...

  7. Prevalencia de parásitos intestinales en niños de diferentes niveles de educación del distrito de San Marcos, Ancash, Perú.

    Directory of Open Access Journals (Sweden)

    Eleuterio Jacinto

    2012-10-01

    Full Text Available Objetivo: Investigar la prevalencia de parasitosis intestinal en estudiantes del Distrito de San Marcos, en el departamento de Ancash, Perú. Material y métodos: Se analizaron en total 1303 muestras de heces de niños de nivel inicial, primario y secundario, mediante examen directo. Resultados: Se encontró uno o más parásitos intestinales en 65,0% de los estudiantes. De las 845 muestras positivas para parásitos, se encontró un parasito en 82,0% dos en18,0% predominando los protozoarios sobre los helmintos. Los enteroparásitos patógenos encontrados según su frecuencia fueron: Giardia lamblia 23,7%, Ascaris lumbricoides 16,9% e Hymenolepis nana 9,6%. La frecuencia del enteroparásito no patógeno Entamoeba coli fue 31,8%. Conclusiones: Existe un alto índice de parasitismo en la población rural de la sierra de Ancash, lo que estaría en relación con las deficientes condiciones de saneamiento ambiental en esta zona, por lo que es necesario que en los colegios de la zona, se dé educación sobre higiene personal y además, mejorar las condiciones de saneamiento.

  8. Technique de la membrane induite pour la reconstruction des pertes ...

    African Journals Online (AJOL)

    humérus par la technique de la membrane induite au moyen d'une fibula non vascularisée avec apport de substitut osseux complémentaire chez une adolescente de 14 ans. Un incident cicatriciel a été observé sur le site de prélèvement.

  9. Epidemiología y diagnóstico de Calodium hepaticum y parásitos intestinales en áreas remotas amazónicas

    OpenAIRE

    Queiroga Gonçalves, Alessandra

    2014-01-01

    [spa] Introducción: Las infecciones por parásitos transmitidos por vía fecal-oral son frecuentes en áreas remotas de la Amazonia. No obstante, la epidemiología de estos parásitos en la Amazonia y la validez de técnicas de laboratorio tradicionales empleadas en el diagnóstico permanecen hasta hoy poco estudiadas. Objetivos: Estudio 1: Estudiar la dinámica de la transmisión de Calodium hepaticum en una comunidad rural del municipio de Presidente Figueiredo, estado del Amazonas, Brasil; Estudio ...

  10. Numerical analysis of resonances induced by s wave neutrons in transmission time-of-flight experiments with a computer IBM 7094 II; Methodes d'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol et automatisation de ces methodes sur ordinateur IBM 7094 II

    Energy Technology Data Exchange (ETDEWEB)

    Corge, Ch. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1969-01-01

    Numerical analysis of transmission resonances induced by s wave neutrons in time-of-flight experiments can be achieved in a fairly automatic way on an IBM 7094/II computer. The involved computations are carried out following a four step scheme: 1 - experimental raw data are processed to obtain the resonant transmissions, 2 - values of experimental quantities for each resonance are derived from the above transmissions, 3 - resonance parameters are determined using a least square method to solve the over determined system obtained by equalling theoretical functions to the correspondent experimental values. Four analysis methods are gathered in the same code, 4 - graphical control of the results is performed. (author) [French] L'automatisation, sur ordinateur IBM 7094/II, de l'analyse des resonances induites par les neutrons s dans les experiences de transmission par temps de vol a ete accomplie en la decomposant selon un schema articule en quatre phases: 1 - le traitement des donnees experimentales brutes pour obtenir les transmissions interfero-resonnantes, 2 - la determination des grandeurs d'analyse a partir des transmissions precedentes, 3 - l'analyse proprement dite des resonances dont les parametres sont obtenus par la resolution d'un systeme surabondant. Quatre methodes d'analyse sont groupees en un meme programme, 4 - la procedure de verification graphique. (auteur)

  11. Concordancia entre los métodos de flotación con sulfato de zinc y sedimentación centrífuga para el diagnóstico de parásitos intestinales

    Directory of Open Access Journals (Sweden)

    Elizabete de Jesus Inês

    2016-12-01

    Full Text Available Introducción. El diagnóstico de infecciones parasitarias intestinales depende de la carga de parásitos, la densidad de la gravedad específica de los huevos/ooquistes/quistes de parásitos y de la densidad y viscosidad de los reactivos de flotación o sedimentación usados para procesar las heces. Objetivo. Evaluar la concordancia entre el método de flotación de sulfato de zinc y la sedimentación por centrifugación en la recuperación de helmintos y protozoos en muestras fecales de niños. Materiales y métodos. Las muestras fecales de 330 niños de las guarderías fueron evaluadas por las técnicas de flotación con sulfato de zinc y de sedimentación por centrifugación. Las frecuencias de detección de parásitos por cada método fueron determinadas y se evaluó la concordancia entre las técnicas de diagnóstico por el índice Kappa, con intervalos de confianza del 95%. Resultados. La flotación fecal con sulfato de zinc diagnosticó significativamente más casos de infección por Trichuris trichiura en comparación con la sedimentación por centrifugación (39/330; 11,8% versus 13/330; 3,9%, p<0,001, con un bajo acuerdo entre los métodos Kappa = 0,264 (95% IC, 0,102-0,427. Además, todas las muestras positivas para huevos de Enterobius vermicularis (n=5 y larvas de Strongyloides stercoralis (n=3 fueron diagnosticados solamente por sulfato de zinc. El método de flotación también detectó la mayor parte de las muestras positivas de Giardia duodenalis (74/83; 89,1% versus 67/83; 80,0%. En contraste, la sedimentación identificó con mayor frecuencia los protozoos Blastocystis spp. (38/46; 82,6% que el método ZS (33/46; 71,7%, aunque no se observaron diferencias estadísticamente significativas, con un considerable acuerdo entre los métodos para la identificación de ambos parásitos, Kappa=0,697 (95% CI, 0,691-0,859 and Kappa=0,675 (95% CI, 0,537-0,801, respectivamente. Conclusiones. Este estudio mostró que la flotación centr

  12. Synthèse de matériaux hybrides polymère-argile par polymérisation photo-induite

    Science.gov (United States)

    Benfarhi, S.; Decker, C.; Keller, L.; Zahouily, K.; Bendaikha, T.

    2005-05-01

    L'objectif de cette étude est de synthétiser des matériaux nanocomposites très résistants par un procédé rapide et non polluant, la polymérisation réticulante Pour celà, nous avons incorporé de l'argile préalablement rendue organophile dans des résines multifonctionnelles. Des phyllosilicates (bentonite, montmorillonite) ont été traitées par divers sels d'ammonium pour les rendre organophiles et ainsi compatibles avec la matrice polymère. La polymérisation de la résine lors de l'exposition au rayonnement ultraviolet a été suivie in situ à l'aide de la spectroscopie infrarouge résolue dans le temps. Dans tous les cas, l'argile organophile n'influence pas ou très peu la cinétique de la réaction de photopolymérisation. Le matériau nanocomposite ainsi obtenu est parfaitement transparent, insoluble dans les solvants organiques et présente des propriétés mécaniques nettement améliorées par rapport à la résine seule et au microcomposite, pour un taux de charges compris entre 2 et 5%. L'addition de nanoparticules permet entre autre de réduire de manière efficace la brillance de revêtements UV (plus de 50% pour une résine chargée à 2%). L'association intime de la charge et du liant organique à l'échelle moléculaire confère enfin à ce matériau des propriétés barrières (aux gaz et àl'eau) supérieures celles de la matrice polymère photoréticulée.

  13. Utilisation de l'essai comete et du biomarqueur gamma-H2AX pour detecter les dommages induits a l'ADN cellulaire par le 5-bromodeoxyuridine post-irradiation

    Science.gov (United States)

    La Madeleine, Carole

    Ce memoire est presente a la Faculte de medecine et des sciences de la sante de l'Universite de Sherbrooke en vue de l'obtention du grade de maitre es sciences (M.Sc.) en radiobiologie (2009). Un jury a revise les informations contenues dans ce memoire. Il etait compose de professeurs de la Faculte de medecine et des sciences de la sante soit : Darel Hunting PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Leon Sanche PhD, directeur de recherche (departement de medecine nucleaire et radiobiologie), Richard Wagner PhD, membre du programme (departement de medecine nucleaire et radiobiologie) et Guylain Boissonneault PhD, membre exterieur au programme (departement de biochimie). Le 5-bromodeoxyuridine (BrdU), un analogue halogene de la thymidine reconnu depuis les annees 60 comme etant un excellent radiosensibilisateur. L'hypothese la plus repandue au sujet de l'effet radio sensibilisant du BrdU est qu'il augmente le nombre de cassures simple et double brin lorsqu'il est incorpore dans l'ADN de la cellule et expose aux radiations ionisantes. Toutefois, de nouvelles recherches semblent remettre en question les observations precedentes. Ces dernieres etudes ont confirme que le BrdU est un bon radiosensibilisateur, car il augmente les dommages radio-induits dans l'ADN. Mais, c'est en etant incorpore dans une region simple brin que le BrdU radiosensibilise l'ADN. Ces recherches ont egalement revele pour la premiere fois un nouveau type de dommages produits lors de l'irradiation de l'ADN contenant du BrdU : les dimeres interbrins. Le but de ces travaux de recherche est de determiner si la presence de bromodeoxyuridine dans l'ADN augmente l'induction de bris simple et / ou double brin chez les cellules irradiees en utilisant de nouvelles techniques plus sensibles et specifiques que celles utilisees auparavant. Pour ce faire, les essais cometes et la detection des foci H2AX phosphorylee pourraient permettre d'etablir les effets engendres par

  14. Occlusion intestinale aigue révélant un lymphome T digestif associé ...

    African Journals Online (AJOL)

    La patiente était mise sous chimiothérapie (CHOEP) et régime sans gluten avec une réponse complète au traitement. L'EATL est une complication rare de la MC qui peut être révélée par une occlusion intestinale. Son pronostic peut être amélioré par une prise en charge précoce associant chirurgie et chimiothérapie.

  15. Tratamiento de la parasitosis intestinales frecuentes en Colombia

    Directory of Open Access Journals (Sweden)

    David Botero

    1981-12-01

    Full Text Available En la úitima década se han obtenido importantes avances en el tratamiento de las parasitosis intestinales (1. 2. La droga ideal, efectiva en dosis única contra todos o la mayoría de los parásitos del intestino, de bajo costo y sin toxicidad, todavía no se ha logrado. El enorme número de personas parasitadas, la mayoría de bajos recursos económicos y eluso de tratamientos en masa como medida de salud pública, hacen necesaria la obtención de nuevos medicamentos apropiados para este fin (3. Mencionaremos inicialmente las parasitósis y las drogas recomendadas y nos referiremos posteriormente a las drogas con más detalle.

  16. Étude des matrices sol-gel en film mince par détection de molécule unique en champ large : diffusion moléculaire et agrégation photo-induite

    Science.gov (United States)

    Nutarelli, D.; Débarre, A.; Jaffiol, R.; Julien, C.; Richard, A.; Tchénio, P.; Chaput, F.; Boilot, J. P.

    2004-11-01

    La fluorescence de molécules de colorant dans des matrices sol-gel en film mince a été étudiée par détection de molécule unique. Outre les phénomènes de photo-blanchiment et de clignotement, un processus de photo-agrégation a été observé. Ce phénomène, dont la dynamique dépend de la présence d'oxygène, de l'intensité du laser d'excitation et de la température, montre l'existence de deux classes de molécules dans l'échantillon. Des molécules immobiles et d'autres qui diffusent. L'analyse de la dynamique d'agrégation permettra de dégager certaines caractéristiques du mécanisme de photo-agrégation et d'appréhender le rôle joué par la matrice sol-gel dans ce processus.

  17. Prevalencia de helmintos intestinales en caninos del departamento del Quindío.

    Directory of Open Access Journals (Sweden)

    María Isabel Giraldo

    2005-09-01

    Full Text Available Introducción. Los helmintos intestinales son agentes patógenos que afectan animales domésticos y que a través de ellos pueden infectar humanos. Objetivo. El objetivo del trabajo fue determinar la prevalencia de helmintos intestinales en perros con dueño del departamento del Quindío. Materiales y métodos. Estudio descriptivo prospectivo. Se aplicó una encuesta epidemiológica a los propietarios de los perros. Se recolectaron muestras de heces de los caninos registrados en la jornada de vacunación antirrábica del 2003 en el departamento del Quindío. Las muestras de materia fecal frescas fueron analizadas utilizando la técnica de diagnóstico de Ritchie. Resultados. Se analizaron 324 muestras de heces caninas; el 67,6% de los perros eran de razas puras y el 32,4% razas mestizas. Se encontró una prevalencia del 22,2%; Ancylostoma caninum fue el parásito más frecuente, 13,9%. También se observó Trichuris vulpis, 4,3%; Toxocara canis, 2,5%, y Strongyloides stercoralis, 4,0%. El 2,46% de las mascotas se encontraron multiparasitadas. Conclusión. La frecuencia de helmintos intestinales en el departamento del Quindío fue de 22,2% y la presencia de estos parásitos coincide con factores como la edad y la permanencia del canino en la calle, entre otros. Por esta razón, es necesario establecer programas de vigilancia y prevención en la población humana y canina.

  18. Etiologies et pronostic des occlusions intestinales aigues mécaniques à l’Hôpital National de Zinder: étude transversale sur 171 patients

    Science.gov (United States)

    Adamou, Harissou; Magagi, Ibrahim Amadou; Habou, Oumarou; Magagi, Amadou; Maazou, Halidou; Adamou, Mansour; Harouna, Yacouba

    2016-01-01

    L’occlusion intestinale aigue (OIA) mécanique, représente l’une des pathologies les plus fréquentes en chirurgie digestive d’urgence. L’objectif de cette étude était de décrire les aspects étiologiques et pronostiques des occlusions intestinales aigues mécaniques à l’Hôpital National de Zinder (HNZ), Niger. Il s’agissait d’une étude transversale sur 24 mois (Janvier 2013 à Décembre 2014) ayant inclus tous les patients opérés pour OIA. Les occlusions intestinales mécaniques représentaient 24,50% (n=171) des urgences chirurgicales digestives (n=622). L’âge médian était à 25 ans (extrêmes: 1 jour et 95 ans). Le sexe ratio était à 3,5 en faveur des hommes. Les enfants représentaient 38,60% (n=66). Le siège de l’obstacle était sur le grêle dans 60,82% (n=104), colique dans 21,63%(n=37) et mixte dans 17,54% (n=30). Le mécanisme par strangulation constituait 88,89% (n=152) dont les hernies étranglées avec 49,70% (n=85) et les invaginations intestinales aigues avec 19,88% (n=34) des patients. Les malformations ano-rectales et les tumeurs constituaient les principales étiologies par obstruction avec respectivement 7,02% (n=12) et 3,51% (n=6). Une résection intestinale était faite dans 52 cas (30,41%). Les complications septiques prédominaient (n=39/53), dont la suppuration pariétale (n=23). Le séjour moyen était de 7,82 jours. La mortalité globale était 11,70% (n=20). Celle-ci était corrélée statistiquement à la nécrose intestinale (p=0,01) et au retard d’admission (p=0,04). Les étiologies des OIA sont multiples et dominées par les hernies étranglées. La morbi-mortalité élevée qu’elles entrainent pourrait être évitée par la prise en charge précoce avant l’installation d’une nécrose intestinale. PMID:27800103

  19. (TRIP) induit par une transformation martensitique dans l'acier ...

    African Journals Online (AJOL)

    Les opérations de soudage des aciers s'accompagnent de phénomènes thermiques, métallurgiques et mécaniques. Ces phénomènes induisent inévitablement des champs de contraintes internes dont le rôle peut être déterminant sur la qualité, la tenue mécanique et la durée de vie de notre matériau. Notre travail vise ...

  20. Priapisme induit par la chlorpromazine: A propos de deux cas ...

    African Journals Online (AJOL)

    Priapism is a rare but serious side effect seen with many -adrenergic antagonists, including both typical and atypical antipsychotics. We report here two cases of priapism associated with chlorpromazine. The first one concerns a young man who was admitted for a manic episode in the context of bipolar disorder. The second ...

  1. Hernie paraduodénale gauche: une cause rare d'occlusion intestinale

    Science.gov (United States)

    Alila, Mohammed; Marouni, Abdelouahab; Toughrai, Imane

    2017-01-01

    Nous rapportons l'observation de deux cas présentant une occlusion intestinale aiguë. L'intervention en urgence a trouvé une hernie para-duodénale gauche obstructive à l'origine d'un volvulus, avec nécrose des anses grêles incarcérées pour un patient, traité par résection anastomose en un temps et un grêle souffrant mais viable pour le deuxième malade, traité par la réduction du grêle incarcéré et l'obturation de l'orifice herniaire. Nous discutons à l'occasion de ces observations les particularités diagnostiques et thérapeutiques de cette affection rare. PMID:29138668

  2. Hernie interne supravésicale, cause rare d'occlusion intestinale aiguë

    Science.gov (United States)

    Adamou, Harissou; Habou, Oumarou; Adakal, Ousseini; Magagi, Ibrahim Amadou

    2015-01-01

    La hernie interne supravésicale est rare et se développe au niveau de la fossette supravésicale. Son diagnostic est très souvent fait à l'occasion d'une laparotomie pour occlusion intestinale. Dans ce travail, nous rapportons le cas d'un patient âgé de 49 ans admis aux urgences chirurgicales de l'HNZ pour syndrome occlusif. La laparotomie réalisée a permis de découvrir une anse grêle incarcérée dans une hernie interne supravésicale. Le geste chirurgical a consisté en une résection du sac associée à une fermeture en points séparés et les suites opératoires ont été simples. Devant toute occlusion intestinale aiguë, il faut avoir à l'esprit que la hernie interne supravésicale peut en être une cause inhabituelle. PMID:26401208

  3. Recherche d’alcaloïdes dans les plantes consommées par Pan paniscus et celles utilisées pour le traitement des maladies gastro-intestinales par Homo sapiens à LuiKotale (Parc National de la Salonga en RD Congo)

    OpenAIRE

    Kitengie Matshimba, Gaby; Fruth, Barbara; Bondjengo Ikombe, Nono; Musibono, Dieudonné; Lubini, Constantin; Hohmann, Gottfried

    2014-01-01

    Les plantes comme d’autres êtres vivants ont développé un certain nombre de mécanismes pour se protéger contre les prédateurs et les infections. Les métabolites secondaires sont considérés comme des moyens de défense des plantes contre les herbivores. Servant d’antidotes, dans certains cas, ils peuvent être ingérés pour l'automédication chez les animaux. Depuis 2002, nous avons étudié l'utilisation des plantes par les bonobos (Pan paniscus, Pp) et les humains (Homo sapiens, Hs) à LuiKotale, e...

  4. Prevalencia de parasitosis intestinales en unidades educativas de Ciudad Bolívar, Venezuela

    Directory of Open Access Journals (Sweden)

    José Antonio Nastasi Miranda

    2015-07-01

    Full Text Available Introducción: Las parasitosis intestinales a nivel mundial son un problema de salud pública que afecta a los países en las zonas tropicales. Un grupo muy vulnerable a padecer este tipo de infección son los niños. El objetivo de la presente investigación fue determinar la prevalencia general de parásitos intestinales en las Unidades Educativas de Ciudad Bolívar, entre los años 2009 - 2013. Materiales y Métodos: Fueron obtenidos los trabajos de grado sobre el tema del Departamento de Parasitología y Microbiología y así se recolectaron datos sobre edad, sexo, tipo de parasito, especies y asociaciones parasitarias y poder calcular así dicha prevalencia general. Resultados: Se encontró una prevalencia general de 63,1% sin predilección por la edad o sexo. Los tipos de parásitos más prevalentes fueron los protozoarios con 83,5%. Las especies más prevalentes fueron Blastocystis spp con 39,7%, Entamoeba coli con 15,3%, y Giardia intestinalis con 13,4%. Las asociaciones parasitarias más frecuentes Blastocystis spp con Endolimax nana (21,1% y Blastocystis spp con Entamoeba coli. (7,4%. Discusión: Los resultados de este estudio guardan relación con estudios realizados a nivel nacional como internacional, con respecto a las prevalencias de parasitosis, el predominio de protozoarios sobre helmintos en los últimos años, y la indistinción de la infección parasitaria con respecto al género. Conclusiones: La prevalencia aquí estudiada a manera general es alta, se recomienda seguir haciendo este tipo de estudios en escuelas para denotar el impacto de estas infecciones en niños y la consecuencia que esto conlleva.  Cómo citar este artículo: Nastasi JA. Prevalencia de parasitosis intestinales en unidades educativas de Ciudad Bolívar, Venezuela. Rev Cuid. 2015; 6(2:1077-84. http://dx.doi.org/10.15649/cuidarte.v6i2.181

  5. Prevalencia de helmintos intestinales en gatos domésticos del departamento del Quindío, Colombia

    Directory of Open Access Journals (Sweden)

    Diana Marcela Echeverry

    2012-05-01

    Full Text Available Introducción. Las enfermedades producidas por helmintos están ampliamente distribuidas en elmundo y muchas de ellas se consideran zoonosis. Los animales de compañía cumplen un papeltrascendental en la transmisión a los humanos. Objetivo. Determinar la prevalencia de helmintos intestinales en gatos del departamento del Quindío. Materiales y métodos. Se estudiaron 121 gatos domésticos del departamento del Quindío, delos cuales se registraron los datos de sexo, edad y condición corporal. Se recolectaron heces y seprocesaron mediante las técnicas de Ritchie modificada y de Kato-Katz. Resultados. De los 121 gatos, 42,14 % (IC95%: 33,35-50,94 y 45,45 % (IC95%: 36,58-54,32 resultaronparasitados con alguna especie de helminto adulto según la presencia de huevos en sus heces,mediante las técnicas de Ritchie y de Kato-Katz, respectivamente. Toxocara cati fue el parásito másprevalente (Ritchie: 37,2 %; Kato-Katz: 43 %, seguido por Ancylostoma spp. (Ritchie: 7,43 %; Kato-Katz: 5,78 % y Aelurostrongylus abstrusus (Ritchie: 0,82 %.Sesenta y cinco (53,71 % gatos eran hembras y 56 (46,28 % eran machos; la prevalencia de infecciónfue similar en ambos sexos. Los felinos mayores de 4 años de edad presentaron mayor prevalenciade parásitos (81,8 %, seguidos por los de 1 a 4 años (48,8 % y, por último, por los menores de unaño (28,6 %. Se encontró una buena condición corporal en 77,68 % y este grupo presentó menorfrecuencia de helmintos intestinales. Conclusión. La prevalencia de helmintos intestinales en gatos domésticos del departamento delQuindío fue de 43,8 %, lo que hace necesario establecer programas de vigilancia y prevención en lapoblación humana y felina.   doi: http://dx.doi.org/10.7705/biomedica.v32i3.439

  6. Distribución espacial de las parasitosis intestinales en la ciudad de La Plata, Argentina

    Directory of Open Access Journals (Sweden)

    María I Gamboa

    2014-10-01

    Full Text Available El análisis de las parasitosis a diferentes escalas (regional, local se facilita por el Geographic Information System (GIS, que permite identificar áreas con distinto grado de vulnerabilidad. El objetivo del trabajo fue analizar la distribución espacial de las parasitosis intestinales en el partido de La Plata, estableciendo su relación con las condiciones socio-ambientales para identificar áreas con diferente riesgo epidemiológico. Se completó una encuesta epidemiológica y se tomaron muestras seriadas de materia fecal, analizadas por la técnica de Ritchie. Se calcularon niveles de precariedad y vulnerabilidad (Iv, y se compararon con los resultados parasitológicos. Se analizaron parasitológica y ambientalmente 653 personas, de las cuales 585 (89.6% eran niños y 68 (10.4% adultos. El análisis indicó que los más vulnerables (Iv = 3-4 estaban en el sector con menor acceso a servicios de infraestructura urbana. El índice se encontró fuertemente asociado a la prevalencia total de parasitosis intestinales y a las 4 especies patógenas asociadas a la contaminación fecal del ambiente: Trichuris trichiura, Ascaris lumbricoides, Hymenolepis nana y Giardia lamblia (p < 0.01. Enterobius vermicularis, parásito no vinculado a la condición sanitaria de sus hospedadores, no se asoció al Iv. Hubo asociación estadística entre precariedad y parasitosis y se halló que a mayor Iv mayor frecuencia de parasitosis (p < 0.01. El uso de GIS permitió zonificar las variables socioambientales en un gradiente creciente de condiciones desfavorables y su relación con la presencia de especies patógenas. La continuidad de estos estudios en diferentes regiones de Argentina contribuye a la determinación de áreas en riesgo sanitario.

  7. Seasonal fluctuations in prevalence of dog intestinal parasites in public squares of Mar del Plata city, Argentina and its risk for humans Estacionalidad en la prevalencia de parásitos intestinales caninos en plazas públicas de Mar del Plata, Argentina, y su riesgo para la salud humana

    Directory of Open Access Journals (Sweden)

    V. Andresiuk

    2007-12-01

    Full Text Available The aim of this work is to analyze whether there is a seasonal prevalence of parasites in dog feces from public squares in Mar del Plata city, Argentina, and to evaluate the climatic conditions that promote the development of parasites and allow the transmission to people. The study was performed in 21 squares from June 2001 to May 2002. Samples were processed by the Willis technique. Differences in prevalence of parasites were examined for significance by the Chisquare test. Climatic data were obtained from the Library of the National Meteorological Service of Argentina. Total parasitic prevalence was higher in winter than in summer. The prevalence of Ancylostoma spp. was higher in the summer-autumn period. For Toxocara canis, the prevalence was higher in winter whereas for Trichuris vulpis, it was higher in winter, spring and summer. This work shows high prevalence of total parasites throughout the year. For Ancylostoma spp., summer and autumn might be the seasons with higher sanitary risk. On the other hand, T. canis could present the higher risk to people in winter and, T. vulpis, would be transmitted throughout the whole year. The seasonal variation in prevalence of dog parasites results in continuous exposure to people visiting the squares, not only Mar del Plata residents but also tourists from other regions of Argentina and the world, with at least one species of parasite with sanitary risk.El objetivo de este trabajo es analizar la variación estacional de la prevalencia de los parásitos presentes en las heces caninas halladas en plazas públicas de la ciudad de Mar del Plata y evaluar aquellas condiciones climáticas que promueven su desarrollo y permiten su transmisión a la gente. El estudio se realizó en 21 plazas desde junio de 2001 hasta mayo de 2002. Las muestras fueron procesadas con la técnica de Willis. Se utilizó el test de c² para comparar la prevalencia de los diferentes parásitos. Los datos climáticos fueron

  8. Les invaginations intestinales chez l'adulte: à propos de 17 cas ...

    African Journals Online (AJOL)

    Les invaginations intestinales chez l'adulte: à propos de 17 cas. Elhattabi Khalid, Bensardi Fatimazahra, Khaiz Driss, Fadil Abdelaziz, Raouah Abdellatif, Lefriyekh Rachid, Benissa Nadia, Berrada Saad, Zerouali Ouariti Najib ...

  9. Evidence of a genetic instability induced by the incorporation of a DNA precursor marked with tritium; Mise en evidence d'une instabilite genetique induite par l'incorporation d'un precurseur de L'ADN marque au tritium

    Energy Technology Data Exchange (ETDEWEB)

    Saintigny, Y.; Laurent, D.; Lahayel, J.B. [CEA Fontenay-aux-Roses, IRCM-LRTS, U967 - CEA/INSERM/Universites Paris 7 and Paris-11, 92 (France); Roche, St.; Meynard, D.; Lopez, B.S. [CEA Fontenay-aux-Roses, LMR - UMR 217 - CEA/CNRS, Institut de Radiobiologie Cellulaire et moleculaire, Direction des Sciences du Vivant, 92 (France)

    2009-07-01

    The authors report a molecular geno-toxicology investigation which allowed molecular events induced par intracellular incorporation of tritium to be studied, and the genetic instability resulting from a chronic exposure even at low dose to be analysed. For this purpose, they developed cell models (hamster tumorous cells and human fibroblasts) in which they know how to incorporate given quantities of marked nucleotides in the DNA. They show that the incorporation of tritium, even with doses which are said to be non toxic, causes a prolonged exposure of the cell to a genotoxic stress, and maybe a genetic instability due to a too great number of recombination events

  10. Características de la infección por geohelmintos intestinales en escolares primarios de la provincia de Las Tunas

    Directory of Open Access Journals (Sweden)

    Rebeca M. Laird Pérez

    2014-08-01

    Full Text Available Se realizó un estudio transversal descriptivo, en el período comprendido entre los meses de septiembre y diciembre de 2004, con el objetivo de caracterizar la infección por geohelmintos intestinales en escolares de la enseñanza primaria de la provincia de Las Tunas. Se estudiaron 1 342 escolares pertenecientes a 35 escuelas de los estratos urbano y rural de los ocho municipios de la provincia. De cada escolar se procesó una muestra de heces por los procedimientos Directo y Kato Katz y se practicó el método de Harada Moris cuando se observaron huevos de ancylostomídeos. A los escolares parasitados por geohelmintos se les determinó su condición clínica. Se obtuvo una prevalencia general de la infección por geohelmintos intestinales del 16,2%, con predominio de la intensidad general de la infección ligera. Los gusanos trichúridos fueron los más observados, asociados a la mayoría de las infecciones con intensidades ligeras y moderadas. Prevaleció el estado clínico asintomático con muy poca morbilidad específica, siendo el dolor abdominal y la diarrea no disentérica los síntomas más frecuentes. Se caracterizó a la provincia de Las Tunas como una zona hipoendémica de geohelmintos intestinales y se recomienda identificar los determinantes de la infección por estos parásitos en la población escolar

  11. Parasitosis intestinales en Argentina: principales agentes causales encontrados en la población y en el ambiente

    Directory of Open Access Journals (Sweden)

    María M Juárez

    Full Text Available Las parasitosis intestinales se encuentran ampliamente distribuidas en el mundo, con mayor prevalencia en los países en desarrollo. Principalmente afectan a los niños, en los que además provocan disminución del desarrollo físico y mental, situación que puede potenciarse enormemente cuando se suma a un estado nutricional deficiente. La Organización Mundial de la Salud las considera una de las principales causas de morbilidad, estrechamente ligada a la pobreza y relacionada con inadecuada higiene personal, incorrecta manipulación de los alimentos crudos, falta de servicios sanitarios, falta de provisión de agua potable y contaminación fecal del ambiente. Algunas enfermedades parasitarias se vinculan con condiciones de transmisión que existen universalmente, por lo que son cosmopolitas, mientras que otras tienen distribución geográfica variable. En los últimos años, debido a la globalización, el movimiento de personas de zonas endémicas a regiones no endémicas ha permitido la diseminación de ciertas parasitosis. Y aunque también influyen en la frecuencia de algunas de estas enfermedades las costumbres de los pueblos, las condiciones ambientales son un factor determinante para la supervivencia de los parásitos. En nuestro país, debido a la diversidad de suelos y condiciones climáticas que existen, es posible hallar variedad de agentes causales de estas parasitosis. El objetivo de este trabajo fue realizar una revisión bibliográfica de los agentes parasitarios causantes de enfermedades entéricas encontrados en la República Argentina, tanto en materia fecal de personas como en el ambiente, ya que la contaminación parasitaria de este último constituye un indicador directo del riesgo de infección por parásitos intestinales.

  12. FERTILIDAD Y EMBARAZO EN PACIENTES CON ENFERMEDADES INFLAMATORIAS INTESTINALES

    Directory of Open Access Journals (Sweden)

    ANDRÉS YARUR U., DR.

    2015-09-01

    Full Text Available Las Enfermedades Inflamatorias Intestinales (EII son entidades crónicas del tracto digestivo, que afectan frecuentemente a pacientes en edad reproductiva. Debido a las características de estas enfermedades y su tratamiento, existen múltiples desafíos. En este artículo, revisamos la evidencia más reciente con respecto a fertilidad y embarazo en pacientes con EII. En general, existe evidencia de que pacientes con EII tienen una mayor tasa de complicaciones durante el embarazo con respecto a pacientes sin EII. Sin embargo, esta diferencia está directamente asociada al grado de actividad de la enfermedad. La mayor parte de los fármacos hoy usados en el tratamiento de EII son considerados seguros durante el embarazo y se recomienda continuarlos, sobre todo considerando que el mayor riesgo de complicaciones está asociado a una enfermedad activa. Sin embargo es importante considerar las opciones caso a caso. Las dos grandes excepciones son metotrexato y talidomida que están completamente contraindicadas. La recomendación más importante es educar a toda paciente con EII en edad reproductiva, explicando que el embarazo debe llevarse a cabo cuando la enfermedad esté controlada y que la probabilidad de complicaciones está relacionada con el grado de actividad y severidad de la EII. Los médicos tratantes deben educar a las pacientes, enfatizando el seguimiento de los controles y tratamiento.

  13. Prevalencia de helmintos intestinales en caninos del departamento del Quindío.

    OpenAIRE

    María Isabel Giraldo; Nora Lizeth García; Jhon Carlos Castaño

    2005-01-01

    Introducción. Los helmintos intestinales son agentes patógenos que afectan animales domésticos y que a través de ellos pueden infectar humanos. Objetivo. El objetivo del trabajo fue determinar la prevalencia de helmintos intestinales en perros con dueño del departamento del Quindío. Materiales y métodos. Estudio descriptivo prospectivo. Se aplicó una encuesta epidemiológica a los propietarios de los perros. Se recolectaron muestras de heces de los caninos registrados en la jornada de vacunaci...

  14. Pneumatose kystique iléale révélée par un volvulus du grêle

    Directory of Open Access Journals (Sweden)

    Khalid Aït Taleb

    2010-08-01

    Full Text Available La pneumatose kystique intestinale est une pathologie rare qui se caractérise par la présence de kystes gazeux dans la paroi intestinale. Elle est asymptomatique ou pauci symptomatique, et le plus souvent découverte lors d’un examen d’imagerie ou d’endoscopie. Nous rapportons un cas de pneumatose iléale compliquée d’un volvulus sur bride chez un patient jamais opéré auparavant.

  15. Syndrome d´Apple-Peel avec nécrose intestinale | Khattala | Pan ...

    African Journals Online (AJOL)

    Syndrome d´Apple-Peel avec nécrose intestinale. Khalid Khattala, Youssef Bouabdallah. Abstract. Pan African Medical Journal 2012; 13:63. Full Text: EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT · DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT · AJOL African Journals Online. HOW TO USE AJOL.

  16. Une surstructure de α-Ge, type diamant, induite par un dopage d'antimoine

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    Adrian Gómez Herrero

    2017-05-01

    Full Text Available Single crystals of antimony-doped germanium, Ge1–xSbx+0.01 (x ≃ 0.0625, were grown by chemical transport reaction. The alloy crystallizes as a superstructure of diamond-type α-Ge. All atoms in the asymmetric unit lie on special positions and are characterized by strong covalent bonds. The antimony atoms substitute for one germanium atom at full occupancy at Wyckoff position 4a (site symmetry -43m, and are also at an adjacent tetrahedral interstitial site with partially occupation (16% at position 4c (or 4d (site symmetry -43m. The structural model does not show close Sb...Sb contacts, and suggests that the interstitial antimony atoms move between the two adjacent tetrahedral sites.

  17. Une surstructure de α-Ge, type diamant, induite par un dopage d'anti-moine.

    Science.gov (United States)

    Herrero, Adrian Gómez; Hammoudi, Lamia; Kars, Mohammed; Roisnel, Thierry; Otero-Diáz, L Carlos

    2017-05-01

    Single crystals of anti-mony-doped germanium, Ge 1- x Sb x +0.01 ( x ≃ 0.0625), were grown by chemical transport reaction. The alloy crystallizes as a superstructure of diamond-type α-Ge. All atoms in the asymmetric unit lie on special positions and are characterized by strong covalent bonds. The anti-mony atoms substitute for one germanium atom at full occupancy at Wyckoff position 4 a (site symmetry -43 m ), and are also at an adjacent tetra-hedral inter-stitial site with partially occupation (16%) at position 4 c (or 4 d ) (site symmetry -43 m ). The structural model does not show close Sb⋯Sb contacts, and suggests that the inter-stitial anti-mony atoms move between the two adjacent tetra-hedral sites.

  18. Réponse glycémique induite par quatre boissons alcoolisées ...

    African Journals Online (AJOL)

    Après avis éthique, 40 sujets (24 hommes, 16 femmes), volontaires, ont été sélectionnés parmi les étudiants de l'Université de Parakou (Bénin) et répartis en 4 groupes de 10. Chaque groupe de sujets a consommé 1000 KJ de l'une des quatre boissons (tchoukoutou, sodabi, vin de palme frais, vin de palme fermenté) seule ...

  19. Hydronéphrose géante sur rein ectopique pelvien révélée par un ...

    African Journals Online (AJOL)

    Les auteurs rapportent un cas d'hydronéphrose majeure sur un rein gauche ectopique en position pelvienne, chez un patient de 17 ans, révélé par une occlusion intestinale aigüe. Un drainage premier par néphrostomie per-cutanée écho-guidée a permis de soulager la patient. Le traitement définitif a consisté en une ...

  20. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    Directory of Open Access Journals (Sweden)

    Graciela Teresa Navone

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p < 0,01; defecación a cielo abierto, ausencia de calzado y ancilostomídeos (p < 0,01; el tipo de vivienda y los helmintos en general (p < 0,01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  1. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    Directory of Open Access Journals (Sweden)

    Navone Graciela Teresa

    2006-01-01

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p < 0,01; defecación a cielo abierto, ausencia de calzado y ancilostomídeos (p < 0,01; el tipo de vivienda y los helmintos en general (p < 0,01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  2. Métastases gastro-intestinales du cancer du sein: à propos de 2 cas ...

    African Journals Online (AJOL)

    Le cancer du sein est le cancer le plus fréquent chez la femme, notamment au Maroc, avec un taux de mortalité élevé. Les métastases gastro- intestinales d'un carcinome canalaire du sein sont rares. Leur diagnostic est difficile du fait de la nature non spécifique des symptômes. Nous rapportons deux observations ...

  3. La hernie diaphragmatique de Bochdalek étranglée: cause rare d’occlusion intestinale

    Science.gov (United States)

    Abdelhalim, Mahmoudi; Mohamed, Rami; Khalid, Khattala; Souad, Dahri; Abderrahmane, Afifi My; Youssef, Bouabdallah

    2012-01-01

    La Hernie diaphragmatique de Bochdalek étranglée comme cause d’occlusion intestinale est très rare. Nous rapportons le cas d’un enfant de 18 mois ayant une hernie à manifestation tardive découverte au stade d’occlusion intestinale. L’enfant s’est présenté dans un tableau d’occlusion intestinale. La radiographie thoracoabdominale a montré la présence de clartés digestives en intrathoracique avec des niveaux hydroaeriques. L’exploration chirurgicale a objectivé une hernie postéro latérale gauche de Bochdalek avec étranglement du colon transverse et du grand épiploon. Le geste a consisté en la réduction des organes herniés avec fermeture du défect diaphragmatique. L’évolution est favorable avec un recul de 2 ans. PMID:22593784

  4. Occlusion par hernie interne transmesenterique congénitale: à propos de deux cas

    Science.gov (United States)

    Ouedraogo, Souleymane; Ouedraogo, Salam; Kambire, Jean Luc; Zida, Maurice; Sanou, Adama

    2017-01-01

    La hernie interne à travers un défect du mésentère ou hernie transmésentérique est une cause rare d'occlusion intestinale aiguë. Son diagnostic est le plus souvent réalisé en per opératoire. La connaissance de ses particularités cliniques permet d'envisager le diagnostic préopératoire. Nous présentons 2 cas d'occlusion intestinale aiguë causée par une hernie transmésentérique congénitale chez 2 adultes. Nous discutons des particularités cliniques de cette forme rare de hernie interne. PMID:28904661

  5. Folie induite: relato de um caso à margem das classificações atuais Folie induite: report of a case outside of the actual classifications

    Directory of Open Access Journals (Sweden)

    Fernando Toledo da Cunha

    2008-01-01

    Full Text Available Na classificação de Gralnick, de 1942, a folie à deux é dividida em quatro subtipos básicos: folie imposée, folie communiquée, folie simultannée e folie induite. O último termo se refere à adição de novas idéias delirantes por paciente previamente psicótico sob influência de outro paciente. Relatamos um caso de folie induite ocorrido entre mãe e filho primariamente psicóticos (transtorno delirante e esquizofrenia, respectivamente, que passaram a compartilhar delírios de natureza persecutória e sexual. Casos de folie à deux geralmente correspondem ao transtorno psicótico induzido (DSM-IV-TR ou transtorno delirante induzido (CID-10. No entanto, o paciente deste relato não pode receber tais diagnósticos, já que nos critérios validados atualmente percebe-se a exigência de que o parceiro induzido não possua um transtorno psicótico anterior ao início do compartilhamento do delírio. Consideramos que o presente relato exemplifica a insuficiência das modernas classificações nesta área. Casos de folie induite podem necessitar de manejo distinto dos demais casos de psicose compartilhada ou não compartilhada. Sugerimos que os critérios diagnósticos correntes poderiam ser revisados para incluir condições psiquiátricas como essa.In the Gralnick classification of 1942 the term folie à deux is classically divided into four basic subtypes: folie imposée, folie communiquée, folie simultannée and folie induite. This last one refers to the addiction of new delusions in a previous psychotic patient, under the influence of another patient. We report a case of folie induite that occurred between mother and son, both diagnosed previously with psychotic disorders (delusional disorder and schizophrenia, respectively, who started to share persecutory and sexual delusions. Cases of folie à deux generally correspond to the induced psychotic disorder in the DSM-IV-TR or the induced delusional disorder in the ICD-10. However, our

  6. Asociación de las poliaminas con enfermedades inflamatorias intestinales. Influencia sobre el epitelio y la motilidad intestinal.

    OpenAIRE

    Flórez Escanciano, Blanca Henar

    2014-01-01

    Las poliaminas son unas moléculas catiónicas con múltiples funciones relacionadas con el desarrollo del epitelio intestinal y alteraciones del sistema inmunitario, ambos aspectos se encuentran afectados en los pacientes con enfermedades inflamatorias intestinales. Dichas poliaminas podrían ejercer un papel importante en la fisiología de las enfermedades inflamatorias intestinales y ser útiles como posibles marcados diagnósticos, por lo que determinamos mediante HPLC aminas biógenas de pacient...

  7. Control de la calidad del diagnóstico coproparasitológico de geohelmintos intestinales en la provincia Las Tunas

    Directory of Open Access Journals (Sweden)

    Rebeca Margarita Laird Pérez

    2015-11-01

    Full Text Available Con el objetivo de evaluar la calidad del diagnóstico coproparasitológico de los geohelmintos intestinales, se realizó un control de la calidad externo activo en la provincia de Las Tunas, de abril a junio de 2012. Se evaluaron las habilidades de 22 profesionales de la Atención Primaria de Salud, para realizar el procedimiento de Kato Katz, la identificación parasitaria e informe de resultados y se les midió el nivel de conocimientos sobre aspectos de interés del diagnóstico de estos gusanos. Se realizaron evaluaciones cualitativas de cada parámetro y se estableció un esquema general de calificación. Las principales deficiencias se presentaron en el informe de resultados, específicamente en la identificación de las especies antropozoonóticas (72,7% evaluados de regular, mientras que la mayoría tuvo resultados favorables en la realización de Kato Katz (54,5% excelente y 27,2% bien y en el nivel de conocimientos (13,6% excelente y 54,5% bien.

  8. Perforation iléo-caecale par corps étranger ingéré chez l'enfant. A ...

    African Journals Online (AJOL)

    iléon à 6 centimètres de la jonction iléo caecale, et l'autre sur le caecum. Ces perforations étaient dues à la nécrose intestinale par trois piles boutons rondes plates et aimantées, dont deux étaient accolées. La fermeture des perforations était ...

  9. Automation on computer of the partial area method in the analysis of resonances induced by 'S' neutrons 2. with an interference term and extension of the method to the treatment of multi resonances (1963); Automatisation sur ordinateur de la methode des aires partielles dans l'analyse des resonances induites par les neutrons ''S''. 2, avec terme d'interference et extension de la methode au traitement des multiresonances (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Bianchi, G.; Corge, C.R. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    This report deals with the numerical analysis on an I.B.M. 7090 computer of transmission resonances induced by 's' wave neutrons in time of flight experiments. The analysis method used is the partial area one. In this second part the interference term is taken into account. Modifications have been made in the programs and subroutines described in the first part, to determine the resonant transmissions from experimental raw data, and the relating partial areas. Also programs and subroutines are thoroughly described, which estimate the resonance parameters. The field of the partial area method has been extended to cover the case where several resonances have to be treated simultaneously, provided they do not interfere. (authors) [French] Le pretent rapport a pour objet l'analyse numerique sur ordinateur I.B.M. 7090 des resonances dues aux neutrons ''s'' dans les experiences de transmission par temps de vol, la methode d'analyse utilisee etant la methode dea aires partielles. Dans cette deuxieme partie il a ete tenu compte du terme d'interference. On y trouvera une description des amenagements apportes aux programmes et sous-programmes decrits dans la premiere partie pour determiner les transmissions interfero-resonnantes a partir des donnees experimentales brutes et les aires partielles afferentes. Sont egalement decrits les programmes et sous-programmes necessaires au calcul des parametres caracteristiques des resonances. Le domaine d'application de la methode a ete etendu au traitement simultane de plusieurs resonances groupees n'interferant pas entre elles. (auteurs)

  10. Effet thérapeutique de l’extrait aqueux de Globularia alypum suite à une insulinotoxicité induite in vitro sur les cardiomyocytes de Rattus norvegicus. [Therapeutic effect of aqueous extract of Globularia alypum following in vitro insulin induced toxicity on Rattus norvegicus cardiomyocytes

    Directory of Open Access Journals (Sweden)

    Leila SMAIL

    2017-07-01

    Full Text Available Introduction. L’insulino‐résistance, marquée par une réaction inflammatoire via la production de TNF‐α et par l’hyperinsulinémie compensatoire, conduit à long terme à l’installation d’une glucolipotoxicité et du diabète de type 2. Objectif. Dans cette étude, les effets d’un extrait aqueux de Globularia alypum (Ga a été analysé in vitro, suite à un stress induit sur le cardiomyocyte de Rattus norvegicus. Matériel et Méthodes. Le stress a été induit par addition d’une dose élevée d’insuline (10 UI/ mL. Les taux de prolifération ont été déterminés par comptage et les contenus cellulaires en monoxyde d’azote (NO, en malondialdéhyde (MDA et en catalase ont été évalués. Résultats. En présence de la dose élevée d’insuline, les cardiomyocytes ont montré une diminution de la survie cellulaire, un déséquilibre du statut redox en faveur d’une augmentation de NO et de MDA et d’une diminution d’une enzyme du système antioxydant, la catalase. Suite à l’action de l’extrait de Ga, il a été noté une amélioration du taux de prolifération cellulaire, une diminution du taux de No et de MDA ainsi qu’une augmentation de l’activité de la catalase. Conclusion. L’état de stress induit sur le cardiomyocyte par l’insulino‐résistance, mimé par la dose élevée d’insuline, entraîne des altérations physiologiques et biochimiques. Ces dernières, précurseurs de mort cellulaire par apoptose sont atténuées après addition d’un extrait de Globularia alypum, lequel pourrait constituer une cible thérapeutique en aval de l’installation du DT2.

  11. Intestinal parasitoses and environmental factors in a rural population of Argentina, 2002-2003 Parasitosis intestinales y factores ambientales en una población rural de Argentina, 2002-2003

    Directory of Open Access Journals (Sweden)

    Juan A. Basualdo

    2007-08-01

    Full Text Available We evaluate the prevalence of intestinal parasites in 504 people and the degree of association between environmental variables and parasites found in population, soil and water in a rural area of Argentina during 2002-2003. A structured survey was used to evaluate the environmental variables and fecal-human, soil and water samples were analyzed. The prevalence of parasites was 45.4%. Most prevalent protozoa were Blastocystis hominis (27.2% and Giardia lamblia (6.9%, while the most prevalent helminth was Ascaris lumbricoides (3.8%. The analyzed environmental variables showing association (p Hemos evaluado la prevalencia de parásitos intestinales en 504 personas y el grado de asociación entre las variables ambientales y los parásitos intestinales hallados en la población, el suelo y el agua de una zona rural de Argentina durante 2002-2003. Se utilizó una encuesta estructurada para relevar las variables ambientales y se examinaron muestras fecales humanas, de agua y de suelo. La prevalencia parasitaria fue de 45,4%. Los protozoos prevalentes fueron Blastocystis hominis (27,2% y Giardia lamblia (6,9%, mientras que el helminto mas prevalente fue Ascaris lumbricoides (3,8%. Las variables ambientales analizadas que mostraron asociación (p < 0,05 con la presencia de parásitos en la población fueron: casa de cartón-chapa o de madera con piso de tierra, bomba de agua domiciliaria o comunitaria, canilla fuera de la casa o pública y pozo ciego o letrina. Elementos parasitarios fueron hallados en el 82,3% de las muestras de suelo y en el 84,2% de las muestras de agua. En ambas muestras fueron hallados parásitos que también se encontraron en las personas. En este trabajo hemos hallado deficientes condiciones sanitarias asociadas con la presencia de parásitos en las personas y hemos evidenciado que el suelo y el agua contaminada fueron la fuente de esos parasitos.

  12. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

    OpenAIRE

    Juan Carlos Fernández Méndez; José Andrés Pérez Vidal; Berta Fernández Méndez

    2010-01-01

    En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mo...

  13. Guías para el tratamiento de las parasitos intestinales frecuentes en Colombia

    Directory of Open Access Journals (Sweden)

    David Botero R.

    1983-12-01

    Full Text Available Si bien es cierto que no existe droga ideal en ninguna de las ramas de la medicina es necesario destacar que en los últimos años se han obtenido importantes avances en el tratamiento de las parasitosis intestinales (1,2. Es así como hoy se cuenta con antiparasitarios de dosis única, altos grados de efectividad y muy buena tolerancia. Para no citar sino un ejemplo, recordemos cómo los tricocéfalos, hasta hace poco tiempo de difícil tratamiento. hoy pueden ser controlados eficazmente con solo una dosis de medicamento. Tan importantes avances facilitan indudablemente los tratamientos antihelmínticos comunitarios como medida de salud pública. y se convierten en herramienta valiosísima en cualquier plan encaminado a mejorar efectivamente la salud de la comunidad (3.

  14. Parasitosis intestinales en relación con la cultura higiénica de poblaciones rurales de Catamarca.

    Directory of Open Access Journals (Sweden)

    Monferrán, M. C.

    2003-01-01

    Full Text Available Los estudios realizados sobre prevalencia de parasitosis intestinales humanas en comunidades urbanas y rurales en la provincia de Catamarca, revela altos índices. Las causas son múltiples, entre las que se encuentran factores ecológicos y sociales. Las condiciones climáticas imperantes en una zona geográfica resultaran favorables o no a la presentación de algunas parasitosis como por ejemplo las geohelmintiasis.Se atribuye igual importancia a la educación, vivienda, alimentación, recursos económicos, falta de higiene, contaminación ambiental, etc.. Se realizan estudios de prevalencia de parasitosis intestinales en pobladores de dos regiones climáticamente diferentes de nuestra provincia como son los Dptos. La Paz y Paclín detectándose en algunas comunidades índices altos de hasta el 81 %.También se ha notado la influencia climática regional sobre la distribución de las parasitosis intestinales .En La Paz, existe un predominio de las protozoosis y en Paclín las geohelmintiasis son frecuentes y diversas. Las parasitosis detectadas estarían relacionadas en un alto grado a la denominada cultura higiénica, pues las prácticas de la higiene individual y familiar, la deposición de sus excretas, la convivencia con animales domésticos, el manejo de sus rebaños, son costumbres regionales que se han transmitido por generaciones e influyen notablemente en la difusión y la conservación de estos altos índices de parasitosis intestinales en detrimento de la salud de los habitantes.

  15. Radiotherapy-induced pemphigus: a case report; Pemphigus induit par radiotherapie: a propos d'un cas

    Energy Technology Data Exchange (ETDEWEB)

    Mseddi, M.; Bouassida, S.; Khemakhem, M.; Marrekchi, S.; Abdelmaksoud, W.; Hadjtaieb, H.; Turki, H.; Zahaf, A. [Centre Hospitalier Universitaire Hedi-Chaker, Service de Dermatologie, Sfax (Tunisia)

    2005-03-15

    A 61-year-old male patient suffering from squamous cell carcinoma of the lower lip developed pemphigus vulgaris two months after exposure to radiotherapy. Skin lesions were initially localised to the face and neck and later extended over other skin areas. The eruption are improved with gluco-steroid therapy, which were stopped after six months. Pemphigus induced by radiotherapy is rare, latency before the onset of the vesiculo-bullous eruption is variable. Clinical, histological and immunological characteristics are similar to those of other types of pemphigus. (author)

  16. Estado nutricional y parasitosis intestinales en niños residentes en zonas urbana, periurbana y rural del partido de Brandsen (Buenos Aires, Argentina

    Directory of Open Access Journals (Sweden)

    Cesani Rossi, María Florencia

    2007-01-01

    Full Text Available El presente estudio tuvo como objeto analizar el estado nutricional y las parasitosis intestinales en niños de 3 a 6 años de edad, residentes en zonas urbanas (U, periurbanas (PU y rurales (R del partido de Brandsen. La muestra quedó constituida por 600 niños (302 varones y 298 mujeres. Los valores P85#P95 definieron sobrepeso y >P95 obesidad. Se tomaron muestras de materia fecal seriada y escobillado anal que fueron analizadas mediante técnicas de concentración por sedimentación (Ritchie y flotación (Willis. Los datos fueron asociados con las características socioambientales de cada zona. PU presentó prevalencias de baja talla para la edad y parasitosis significativamente mayores que U (p<0.01. Se registraron 7 especies parásitas en U, 8 en PU y 4 en R, siendo Enterobius vermicularis, Blastocystis hominis y Giardia lamblia las especies más abundantes. También el poliparasitismo fue mayor en PU. Aunque el sobrepeso y la obesidad fueron elevados en las tres zonas, las mayores prevalencias se registraron en PU y R respecto de U (p<0.01. La coexistencia de desnutrición y sobrepeso-obesidad, podría vincularse con los cambios experimentados en las costumbres alimentarias y los modos de vida de estas poblaciones en el contexto de la transición nutricional. La zona periurbana presenta las peores condiciones socio-ambientales para el crecimiento y la salud de los niños en edad preescolar.

  17. The origin of cholesterol in chyle demonstrated by nuclear indicator methods; Origines du cholesterol du chyle mises en evidence par la methode des indicateurs nucleaires

    Energy Technology Data Exchange (ETDEWEB)

    Vyas, M

    1962-07-01

    In order to obtain information about the mechanism of the intestinal absorption of cholesterol, rats having a lymphatic abdominal fistula are used. The animals receive either 4-{sup 14}C- cholesterol subcutaneously or orally, or the 1-{sup 14}C acetate. The study of the specific radio-activities of the cholesterol in chyle, in serum, in the lining, and in the intestinal contents makes it possible to define the roles played by the transfer cholesterol from the serum, by the cholesterol synthesised intestinally, and by the absorption cholesterol, in the formations of the lymph and of the chylomicrons. A new theory is proposed for the mechanism of cholesterol absorption. (author) [French] Pour obtenir des renseignements concernant le mecanisme de l'absorption intestinale du cholesterol, on utilise des rats porteurs d'une fistule lymphatique abdominale. Les animaux recoivent soit du cholesterol 4-{sup 14}C par voie sous-cutanee ou par voie orale, soit de l'acetate 1-{sup 14}C. L'etude des radioactivites specifiques du cholesterol du chyle, du serum, de la paroi et du contenu intestinal permet de preciser les roles joues par le cholesterol de transfert d'origine serique, par le cholesterol de synthese intestinale et par le cholesterol d'absorption, dans la formation de la lymphe et des chylomicrons. Une theorie nouvelle concernant le mecanisme de l'absorption du cholesterol est proposee. (auteur)

  18. Intestinal parasitic infections, cysticercosis and hydatic diseases Parasitosis intestinales, cisticercosis e hidatidosis

    Directory of Open Access Journals (Sweden)

    David Botero

    1990-03-01

    Full Text Available

    This paper offers an up to date review of the intestinal parasitic infections, cysticercosis and hydatic disease found In Colombia. Their main epidemiological, clinical, preventive and therapeutic features are presented, to provide the reader with a current view of their public health Importance, prevalence and impact on morbidity and mortality.

    Se presenta una revisión actualizada sobre las parasitosis intestinales, la cisticercosis y la hidatidosis en Colombia, con una breve descripción de la prevalencia, las características epidemiológicas, los efectos sobre la salud y algunos aspectos de control y tratamiento. Con esta revisión se busca tener información resumida sobre las parasitosis que se encuentran en Colombia y su mayor o menor Importancia en salud pública. TambIén se pretende ofrecer una Idea del nivel de gravedad de estas entidades como causas de morbilidad y mortalidad en este país. 

  19. Kerosene detection using laser induced fluorescence imaging for aeronautical engines application; Detection du kerozene par imagerie de fluorescence induite par laser, pour application sur foyer aeronautique

    Energy Technology Data Exchange (ETDEWEB)

    Baranger, Ph.

    2004-10-15

    The new concepts of aeronautical engines, developed to follow the evolution of the European standards of pollution, are generally based on an improvement of the processes of liquid fuel injection and mixture in the combustion chamber. There is currently no model mature enough to work without experimental validation. The purpose of this thesis is to assess the possibility of measuring the kerosene (Jet A1) vapour distribution by PLIF (Planar Laser Induced Fluorescence). That measurement technique must quantitatively image the instantaneous concentrations fields of the vaporized fuel in a spray. The implementation of such a technique needs an experimental spectroscopic study, which was realized on the vapour of fuel. First of all, this study allowed us to determine the properties of the kerosene fluorescence spectrum versus physical parameters such as temperature, pressure or gas mixture composition, especially in presence of oxygen molecules. Then, it was shown that the fluorescence spectrum of the fuel could be reproduce in all physical conditions by a single mixture of four aromatics. Their photophysical properties were also analyzed. Following this spectroscopic study, a phenomenological model for the fluorescence of the gaseous fuel was set up. This model led us to a protocol for an optical diagnostic on this fuel vapour. An experiment was set up to test the implementation and the limits of this technique in simple laboratory conditions. This experiment confirmed that this is indeed a promising technique for the diagnostic of the fuel vapour in aeronautical engine. (author)

  20. Amorphization of silicon via electronic processes induced by irradiation with fullerenes; Amorphisation du silicium par processus electroniques induits par irradiation avec des fullerenes

    Energy Technology Data Exchange (ETDEWEB)

    Canut, B.; Bonardi, N.; Ramos, S.M.M. [Universite Claude Bernard, Dept. de Physique des Materiaux, UMR CNRS, 69 - Lyon (France); Della Negra, S. [Institut de Physique Nucleaire, (IN2P3/CNRS) 91 - Orsay (France)

    1999-07-01

    For the first time it is shown that single crystalline silicon is sensitive to collective electronic excitations. Irradiations with C{sub 60} clusters accelerated in the 10 MeV range induce the formation of amorphous latent tracks in this material. This result has never been observed with high energy heavy ions, it means that what may matter is the very high electronic energy density deposited in the silicon by the incident cluster. TEM (transmission electronic microscopy) analysis of irradiated samples have enable us to measure surface damage cross-sections: 55 nm{sup 2} and 87 nm{sup 2} for irradiations with C{sub 60}{sup 2+} beams and C{sub 60}{sup 3+} beams accelerated respectively to 30 and 40 MeV. (A.C.)

  1. Structure physico-chimique et résistance à la fissuration des bitumes routiers : Thèse de Malo Le Guern au Laboratoire Central des Ponts et Chaussées en partenariat avec Total : Etude des bitumes purs : Influence du vieillissement en laboratoire par 25 heures de PAV

    OpenAIRE

    LE GUERN, Malo

    2008-01-01

    Le bitume peut être caractérisé par différentes méthodes physico-chimiques. Lors du cycle d'utilisation (stockage, enrobage, sur site), le liant subit des vieillissements physiques et chimiques. Dans ce rapport, nous étudions les différences entre les caractéristiques physicochimiques des bitumes purs de natures différentes, sélectionnés pour la thèse, ainsi que les modifications induites par un vieillissement de 25 heures de vieillissement par l'essai de « Pressure Aging Vessel » (PAV), e...

  2. Parasitosis intestinales en relación con la cultura higiénica de poblaciones rurales de Catamarca.

    OpenAIRE

    Monferrán, M. C.

    2003-01-01

    Los estudios realizados sobre prevalencia de parasitosis intestinales humanas en comunidades urbanas y rurales en la provincia de Catamarca, revela altos índices. Las causas son múltiples, entre las que se encuentran factores ecológicos y sociales. Las condiciones climáticas imperantes en una zona geográfica resultaran favorables o no a la presentación de algunas parasitosis como por ejemplo las geohelmintiasis.Se atribuye igual importancia a la educación, vivienda, alimentación, recursos eco...

  3. Parasitosis intestinales en Argentina: Principales agentes causales encontrados en la población y/o en el ambiente

    OpenAIRE

    Juarez, Maria Mercedes; Rajal, Verónica Beatriz

    2015-01-01

    Las parasitosis intestinales se encuentran ampliamente distribuidas en el mundo, con mayor prevalencia en los países en desarrollo. Principalmente afectan a los niños en los que además provocan disminución del desarrollo físico y mental; situación que puede potenciarse enormemente cuando se suma a un estado nutricional deficiente. La Organización Mundial de la Salud las considera una de las principales causas de morbilidad, estrechamente ligada a la pobreza y relacionada con inadecuada higien...

  4. Parasitosis intestinales en poblaciones Mbya-Guaraní de la provincia de Misiones

    Directory of Open Access Journals (Sweden)

    Zonta, María Lorena

    2005-01-01

    Full Text Available El objetivo del trabajo consiste en describir las enteroparasitosis más frecuentes en dos comunidades Mbyá Guaraní de Misiones, Argentina: Kaaguy Poty (KP e Yvy Pytá (YP y su asociación con el estado nutricional y los factores ambientales y culturales que caracterizan a éstas poblaciones. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí (TA y la población urbana más cercana: Aristóbulo del Valle (AV. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se relevaron variables antropométricas (peso y estatura. Se analizaron también muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 88.5%(KP, 88.7%(YP, 96.1% (TA y 82%(AV estuvieron parasitados. De ellos, el 74.3% presentaron poliparasitosis. El 80.6 % de los individuos estaban desnutridos y más del 90% de ellos parasitados. Los datos se procesaron mediante pruebas de chi cuadrado. Los resultados mostraron asociación entre el uso de letrinas y Giardia lamblia (p<0.01; defecación a cielo abierto, ausencia de calzado y Ancilostomídeos (p<0.01 y entre el tipo de vivienda y la presencia de helmintos (p<0.01. En el suelo se hallaron formas parasitarias, sugiriendo la relación entre la contaminación del entorno ambiental y la elevada prevalencia de parasitosis intestinales en las poblaciones estudiadas.

  5. Amélioration de microalgues à vocation énergétique par pression de sélection continue

    OpenAIRE

    Bonnefond , Hubert

    2015-01-01

    The world faces an unprecedented environmental crisis, led by the action always more marked with the man on its environment. From the beginning of the industrial era, the massive use of the fossil fuels, caused a global climatic disorder.; Le monde fait face à une crise environnementale sans précédent, induite par l’action toujours plus marquée de l’homme sur son milieu. Depuis le début de l’ère industrielle, l’utilisation massive des énergies fossiles, a provoqué un dérèglement climatique pl...

  6. Disminución de enfermedades infecciosas intestinales relacionada al acceso a servicios de agua y desagüe en el Perú, 2002-2009

    Directory of Open Access Journals (Sweden)

    Fernando Arenas-Significación

    2011-12-01

    Full Text Available Introducción: En el Perú, las enfermedades infecciosas intestinales ocupan el tercer lugar en causas de morbilidad registradas en consulta externa. Por otro lado, el acceso a agua y desagüe existió en 74,7% y 62,8%, respectivamente. Objetivos: Determinar la correlación del acceso de agua potable y desagüe con las consultas por enfermedades infecciosas intestinales. Diseño: Estudio ecológico de series de tiempo. Institución: Facultad de Medicina de San Fernando, Universidad Nacional Mayor de San Marcos, Lima, Perú. Material: Registros del Ministerio de Salud y del Instituto Nacional de Estadística e Informática, Lima, Perú. Métodos: A partir de los registros del Ministerio de Salud (MINSA de las causas de morbilidad en consulta externa y datos del Instituto Nacional de Estadística e Informática (INEI, se realizó un estudio ecológico de serie de tiempo, del periodo 2002 al 2009. Se analizó los resultados con el coeficiente rho de Spearman. Principales medidas de resultados: Coeficientes de correlación. Resultados: Se obtuvo un rho = -0,810 y p = 0,015 para la relación entre acceso a agua potable y enfermedades infecciosas intestinales. Se obtuvo un rho = -0,714 y p = 0,047 para la relación entre el acceso a desagüe y enfermedades infecciosas intestinales. Interpretación: Se encontró correlación entre el porcentaje de acceso de agua potable y desagüe y el porcentaje de consultas externas por enfermedades infecciosas intestinales, en el periodo del 2002 al 2009, en el Perú.

  7. Arrêt cardiocirculatoire par accidents d’électrisations: intérêt du défibrillateur semi-automatique

    Science.gov (United States)

    Siah, S.; Fouadi, F.E.; Ababou, K.; Ihrai, I.; Drissi, N.K.

    2011-01-01

    Summary Les brûlures par accidents électriques sont graves car elles peuvent entraîner le décès par arrêt cardiocirculatoire. Les arrêts cardiocirculatoires induits par le courant de basse tension sont en règle générale dûs à une fibrillation ventriculaire, plutôt de bon pronostic si la chaîne des secours est efficace. Il faut donner la priorité à la défibrillation systématique d’emblée en utilisant un défibrillateur semi-automatique. La défibrillation électrique est susceptible de procurer immédiatement une restauration de l’activité circulatoire spontanée. PMID:21991238

  8. Influenţa microflorei intestinale asupra variaţiei titrelor de anticorpi postvaccinali contra pseudopestei aviare

    Directory of Open Access Journals (Sweden)

    STARCIUC Nicolae

    2016-06-01

    Full Text Available The investigations are based on determining the influence of intestinal microflora variation on the level of postvaccination antibody titers against Newcastle disease. Thus, several chicken groups were vaccinated and implicitly, there were taken samples for making subsequent serological tests in order to determine the antibody titers and also intestinal lavages to determine microflora. As a result, it was determined that the variation of qualitative intestinal microflora is insignificant and the level of maternal antibody titers against Newcastle disease, at the age of one day, is quite high and it is able to protect chickens up to the age of 15-20 days, when the first vaccination is recommended. Rezumat. Investigaţiile se bazează pe determinarea influenţei variaţiei microflorei intestinale asupra nivelului titrelor de anticorpi postvaccinali împotriva bolii Newcastle. Astfel, mai multe loturi de pui au fost supuse vaccinării, implicit s-au recoltat probe pentru testele serologice ulterioare de determinare a titrelor de anticorpi şi lavaje prelevate de la nivel intestinal, pentru determinarea microflorei. S-a stabilit că variaţia microflorei intestinale calitativă este nesemnificativă şi că nivelul titrelor de anticorpi maternali contra pseudopestei aviare, la vârsta de o zi, este destul de mare, capabil să protejeze puii de găină până la o vârstă de aproximativ 15-20 de zile, atunci când se recomandă prima vaccinare la pui.

  9. Estudio Transversal sobre la Relación entre Neuroticismo y Curso Clínico en Pacientes con Enfermedades Inflamatorias Intestinales

    Directory of Open Access Journals (Sweden)

    Juan Carlos Fernández Méndez

    2010-01-01

    Full Text Available En el presente trabajo se analiza la relación que existe entre neuroticismo y diversas condiciones médicas que hacen referencia al curso clínico de las enfermedades inflamatorias intestinales. Para desarrollar la investigación se tomaron medidas en neuroticismo mediante el Inventario de Personalidad de Eysenck a 106 participantes diagnosticados de colitis ulcerosa y enfermedad de Crohn. Los resultados reflejaron que la muestra global de pacientes con enfermedades inflamatorias intestinales mostraba valores en neuroticismo que se hallaban dentro de la normalidad; sin embargo, se pudo verificar que los valores diferían dependiendo del curso clínico de la patología. El estudio sugiere que las variaciones en neuroticismo son considerables cuando se analizan los datos de la muestra general y cuando se tienen en cuenta diversas condiciones del curso clínico.

  10. Fast neutron dosimetry and spectrometry using radioactivation (1963); Dosimetrie et spectrometrie des neutrons rapides par radioactivation (1963)

    Energy Technology Data Exchange (ETDEWEB)

    Lamberieux, J. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1963-07-01

    The author first recalls rapidly a few generalities concerning induced radioactivity detectors and gives, in an appendix, tables summarizing the properties of detector elements which may be used in radioprotection. The excitation functions found in the literature and also given. The technological characteristics of the detectors used are given, together with the counting methods. The many advantages of activation dosimetry for strong or periodic neutron fluxes and for those in the presence of {gamma}-radiation are stressed. The main problem in activation dosimetry is, however, the calculation of the dose absorbed from the results of the measurements. It is shown how the dose is expressed, fairly accurately, as a function of the radioactivities induced in a series of detectors. As an example, the spectrometry and the dosimetry of the neutron flux emitted by a Po-Be source are presented. (author) [French] L'auteur fait d'abord un bref rappel des generalites sur les detecteurs a radioactivite induite, accompagne, en annexe, des tableaux resumant les proprietes d'elements detecteurs utilisables en radioprotection. Les fonctions d'excitation trouvees dans la litterature y sont egalement annexees. On donne ensuite les caracteristiques technologiques des detecteurs employes ainsi que les methodes de comptage utilisees. On souligne les nombreux avantages de la dosimetrie par activation dans les flux de neutrons intenses ou periodiques et en presence de rayonnement {gamma}. Il reste que le probleme central de la dosimetrie par activation est le calcul de la dose absorbee a partir des resultats de mesure. On montre comment la dose s'exprime, de maniere approchee, en fonction des radioactivites induites dans une serie de detecteurs. A titre d'exemple, la spectrometrie et la dosimetrie du flux de neutrons emis par une source de Po-Be sont presentees. (auteur)

  11. Stratégie de modulation pour la réduction de la tension de mode commun générée par un variateur de vitesse à redresseur MLI

    OpenAIRE

    MESSAOUDI, Mehdi; VIDET, Arnaud; Idir, Nadir; VANG, Heu; BOULHARTS, Hocine

    2014-01-01

    Dans le domaine de la variation de vitesse, les perturbations conduites de mode commun sont les plus difficiles à maîtriser du fait des multiples chemins de propagation possibles. Ces perturbations peuvent être réduites à l'aide de filtres passifs qui sont généralement très volumineux. Une solution pour réduire la taille de ces filtres consiste à réduire les perturbations de mode commun à la source, à savoir la tension de mode commun induite par le convertisseur. C'est dans cette optique que ...

  12. Identificación de Parásitos Gastrointestinales en dos Especies de Delfines en Cautiverio del Acuario y Museo del Mar el Rodadero ubicado en Santa Marta‚ Magdalena -resumen-

    OpenAIRE

    Dave Wehdeking-Hernández; J Rodríguez; C Zuluaga; Luis Barrios; Julio Mejía

    2014-01-01

    Las infecciones parasitarias en animales tienen distribución mundial y se caracterizan por una sintomatología intestinal inespecífica; por procesos clínicos que pueden ser agudos‚ sub agudos y crónicos. La epidemiologia de las parasitosis intestinales es muy variada‚ depende del tipo de parásito‚ del área geográfica‚ del estado general del hospedero y de los hábitos poblacionales. Teniendo en cuenta que los delfines son uno de los principales atractivos del acuario‚ se estableció un protocolo...

  13. Morbilidad y mortalidad por enfermedades infecciosas intestinales (001-009: Cuba, 1980-1999

    Directory of Open Access Journals (Sweden)

    Raúl L. Riverón Corteguera

    2000-06-01

    Full Text Available En los últimos 20 años la mortalidad por enfermedades infecciosas intestinales en menores de 5 años en el mundo se ha reducido de manera significativa; sin embargo, en 1998 se registraron en el nivel mundial 2,2 millones de defunciones en los menores de 5 años. En la actualidad todavía la mortalidad seconsidera un problema de salud muy serio, sobre todo en los países subdesarrollados. En Cuba, la mortalidad por estas enfermedades en los menores de 5 años se ha reducido de manera notable, aunque la morbilidad constituye un problema importante de salud en ciertos meses del año por las alzas estacionales de la enfermedad. Este artículo muestra los resultados del trabajo desplegado a partir de 1980 en el cual se puso en ejecución el Programa Mundial de Control de las Enfermedades Diarreicas por la Organización Mundial de la Salud, que en Cuba es una continuación del Programa Nacional de Lucha contra la Gastroenteritis que se inició en 1962. Los datos de morbilidad se ofrecen desde 1985 según diferentes grupos de edades. Las reducciones en la morbilidad han sido discretas; en los menores de 1 año fue del 30,8 %; en el grupo de 1 a 4 años, 8,0 %; en los menores de 5 años del 20,1 %; en los de 5 a 14 años del 3,5 % y en los menores de 15 años del 15,8 %. Las tasas de mortalidad disminuyeron en el período de 1980 a 1999 en el 91,0 % en los menores de un año; el 50,0 % en los niños de 1 a 4 años; 85,7 % en menores de 5 años; en 66,7 % en el grupo de 5 a 14 años, y en 81,1 % en los menores de 15 años. Los elementos fundamentales que han contribuido a esta disminución en la mortalidad por enfermedades diarreas han sido, en primer lugar el uso de las sales de rehidratación oral, en la prevención y tratamiento de la deshidratación, el uso racional de antimicrobianos, el incremento de la lactancia materna exclusiva, la capacitación de los recursos humanos, el tratamiento intensivo por parte de nuestros profesionales de la salud

  14. Les activités de gestion d’alerte épidémiologique : les transformations induites par l’utilisation d’un système de surveillance en temps réel Alert Management Activity: Cognitive and team activity modifications due to the use of an early warning system Las actividades de gestión de alerta epidemiológica : las transformaciones inducidas por la utilización de un sistema de vigilancia en tiempo real

    Directory of Open Access Journals (Sweden)

    Charlotte Gaudin

    2012-05-01

    Full Text Available Cet article présente une recherche en psychologie cognitive et ergonomique visant à analyser l’activité de gestion d’une alerte épidémiologique. Gérer une alerte épidémiologique est une activité médicale distribuée et complexe consistant en la gestion d’un environnement dynamique puisque l’épidémie évolue et se propage rapidement si aucune action n’est entreprise pour la contrôler. Plus précisément, deux types de situation sont analysées : (1 l’activité traditionnelle de gestion d’alerte et (2 cette même activité lorsqu’elle est assistée par un système informatique, en l’occurrence le système ASTER (ou Alerte et Surveillance en TEmps Réel. Les résultats obtenus sont ensuite discutés au niveau cognitif et au niveau des activités collectives consécutivement à l’introduction et à l’utilisation d’un système technique.This paper presents a study that investigated the management of epidemiological alerts. Alert management is a complex, distributed medical activity. It can be compared to the largest category of dynamic environment management. Two activities were examined. First, we analyzed traditional alert management activity with the MAD method (observations and interviews. Second, we analyzed and characterized alert management activities when supported by the computerized ASTER system (Alerte et Surveillance en TEmps Réel, alert and monitoring in real time. The second analysis was conducted with EORCA method, which is used to describe collective and complex activities. The results highlight various modifications to both the cognitive activity and team activities which were due to the use of the ASTER system.Este artículo presenta una investigación en psicología cognitiva y ergonómica cuyo objetivo es analizar la actividad de gestión de una alerta epidemiológica. Manejar una alerta epidemiológica es una actividad médica distribuida y compleja que consiste en la gestión de un ambiente

  15. Adiestramiento en el diagnóstico de las parasitosis intestinales en la red de laboratorios de Cuba

    Directory of Open Access Journals (Sweden)

    Núñez Fidel Angel

    2001-01-01

    Full Text Available En 1997, se desarrolló un proyecto nacional de adiestramiento integral para el diagnóstico de las parasitosis intestinales, el que incluyó 4 cursos; uno com carácter nacional, y otros 3 en las provincias centrales, orientales y occidentales. Al comparar los errores diagnósticos, vimos que Cryptosporidium parvum, Cyclospora cayetanensis y los leucocitos mostraron un porcentaje significativamente menor de fallas después del curso que al comienzo (p 0,05. Por otra parte, al comparar las medias de las puntuaciones antes y después de los cursos, se encontró un aumento significativo en el curso de las provincias centrales (p<0,05, en las occidentales (p < 0,01, y en la totalidad (p < 0,01, lo que demonstró la efectividad a corto plazo de esta intervención. Sin embargo, pensamos que estas actividades de educación continuada deberian seguirse junto com programas nacionales para el control de la calidad.

  16. Adiestramiento en el diagnóstico de las parasitosis intestinales en la red de laboratorios de Cuba

    Directory of Open Access Journals (Sweden)

    Fidel Angel Núñez

    Full Text Available En 1997, se desarrolló un proyecto nacional de adiestramiento integral para el diagnóstico de las parasitosis intestinales, el que incluyó 4 cursos; uno com carácter nacional, y otros 3 en las provincias centrales, orientales y occidentales. Al comparar los errores diagnósticos, vimos que Cryptosporidium parvum, Cyclospora cayetanensis y los leucocitos mostraron un porcentaje significativamente menor de fallas después del curso que al comienzo (p 0,05. Por otra parte, al comparar las medias de las puntuaciones antes y después de los cursos, se encontró un aumento significativo en el curso de las provincias centrales (p<0,05, en las occidentales (p < 0,01, y en la totalidad (p < 0,01, lo que demonstró la efectividad a corto plazo de esta intervención. Sin embargo, pensamos que estas actividades de educación continuada deberian seguirse junto com programas nacionales para el control de la calidad.

  17. FooPar

    DEFF Research Database (Denmark)

    Hargreaves, F. P.; Merkle, D.

    2013-01-01

    We present FooPar, an extension for highly efficient Parallel Computing in the multi-paradigm programming language Scala. Scala offers concise and clean syntax and integrates functional programming features. Our framework FooPar combines these features with parallel computing techniques. Foo...

  18. suPAR

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Wachtell, Kristian

    2015-01-01

    The fundamental role of inflammation in cardiovascular disease (CVD) has prompted interest in numerous biomarkers that detect subclinical levels of inflammation. Soluble urokinase plasminogen activator receptor (suPAR) is a novel biomarker that correlates significantly with cardiovascular events...... comprehensive review of suPAR in CVD and explore its function and usefulness in predicting cardiovascular events....

  19. Par Pond water balance

    International Nuclear Information System (INIS)

    Hiergesell, R.A.; Dixon, K.L.

    1996-06-01

    A water budget for the Par Pond hydrologic system was established in order to estimate the rate of groundwater influx to Par Pond. This estimate will be used in modeling exercises to predict Par Pond reservoir elevation and spillway discharge in the scenario where Savannah River water is no longer pumped and discharged into Par Pond. The principal of conservation of mass was used to develop the water budget, where water inflow was set equal to water outflow. Components of the water budget were identified, and the flux associated with each was determined. The water budget was considered balanced when inflow and outflow summed to zero. The results of this study suggest that Par Pond gains water from the groundwater system in the upper reaches of the reservoir, but looses water to the groundwater system near the dam. The rate of flux of groundwater from the water table aquifer into Par Pond was determined to be 13 cfs. The rate of flux from Par Pond to the water table aquifer near the dam was determined to be 7 cfs

  20. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales

    OpenAIRE

    Navone Graciela Teresa; Gamboa María Inés; Oyhenart Evelia Edith; Orden Alicia Bibiana

    2006-01-01

    Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Rit...

  1. Dinámica para la identificación de las formas parasitarias microscópicas de los geohelmintos intestinales

    OpenAIRE

    Rebeca Margarita Laird Pérez; Alexander Morales Fontaine

    2015-01-01

    Las estadísticas sobre geohelmintos intestinales, a partir del examen parasitológico de las heces, constituye la espina dorsal de los programas para el control de estos gusanos, pues a partir de ellas se obtiene información útil para la toma de decisiones; no obstante, existen insuficiencias cognoscitivas y en las habilidades para la identificación de formas microscópicas de geohelmintos por parte del personal del laboratorio, así como deficiencias didácticas en el abordaje bibliográfico sobr...

  2. Study of structural modifications induced by ion implantation in austenitic stainless steel; Etude des modifications structurales induites par implantation ionique dans les aciers austenitiques

    Energy Technology Data Exchange (ETDEWEB)

    Dudognon, J

    2006-12-15

    Ion implantation in steels, although largely used to improve the properties of use, involves structural modifications of the surface layer, which remain still prone to controversies. Within this context, various elements (N, Ar, Cr, Mo, Ag, Xe and Pb) were implanted (with energies varying from 28 to 280 keV) in a 316LVM austenitic stainless steel. The implanted layer has a thickness limited to 80 nm and a maximum implanted element concentration lower than 10 % at. The analysis of the implanted layer by grazing incidence X ray diffraction highlights deformations of austenite lines, appearance of ferrite and amorphization of the layer. Ferritic phase which appears at the grain boundaries, whatever the implanted element, is formed above a given 'threshold' of energy (produced of fluency by the energy of an ion). The formation of ferrite as well as the amorphization of the implanted layer depends only on energy. In order to understand the deformations of austenite diffraction lines, a simulation model of these lines was elaborated. The model correctly describes the observed deformations (broadening, shift, splitting) with the assumption that the expansion of the austenitic lattice is due to the presence of implanted element and is proportional to the element concentration through a coefficient k'. This coefficient only depends on the element and varies linearly with its radius. (author)

  3. Multicharged Ion-induced simple molecule fragmentation dynamics; Dynamique de la fragmentation de molecules simples induite par impact d'ion multicharge

    Energy Technology Data Exchange (ETDEWEB)

    Tarisien, M

    2003-10-01

    The aim of this work is to study the dynamics of swift multicharged ion-induced fragmentation of diatomic (CO) and triatomic (CO{sub 2}) molecules. Performed at the GANIL facility, this study used the Recoil Ion Momentum Spectroscopy technique (RIMS), which consists of a time-of-flight mass spectrometer, coupled with a multi-hit capability position sensitive detector (delay line anode). The high-resolution measurement of the kinetic energy distribution released (KER) during the CO fragmentation points out the limitation of the Coulomb Explosion Model, revealing, for example, the di-cation CO{sub 2}{sup +} electronic state contribution in the case of C{sup +}/O{sup +} fragmentation pathway. Furthermore, the multi-ionization cross section dependence with the orientation of the internuclear axis of CO is compared with a geometrical model calculation. Finally, different behaviours are observed for the dissociation dynamics of a triatomic molecule (CO{sub 2}). While triple ionization leads mainly to a synchronous concerted fragmentation dynamics, a weak fraction of dissociating molecule follows a sequential dynamics involving CO{sub 2}{sup +} metastable states. In the case of double ionization, (CO{sub 2}){sup 2+} di-cation dissociation dynamics is asynchronously concerted and has been interpreted using a simple model involving an asymmetrical vibration of the molecule. (author)

  4. Irradiation induced surface segregation in concentrated alloys: a contribution; Contribution a l`etude de la segregation de surface induite par irradiation dans les alliages concentres

    Energy Technology Data Exchange (ETDEWEB)

    Grandjean, Y.

    1996-12-31

    A new computer modelization of irradiation induced surface segregation is presented together with some experimental determinations in binary and ternary alloys. The model we propose handles the alloy thermodynamics and kinetics at the same level of sophistication. Diffusion is described at the atomistic level and proceeds vis the jumps of point defects (vacancies, dumb-bell interstitials): the various jump frequencies depend on the local composition in a manner consistent with the thermodynamics of the alloy. For application to specific alloys, we have chosen the simplest statistical approximation: pair interactions in the Bragg Williams approximation. For a system which exhibits the thermodynamics and kinetics features of Ni-Cu alloys, the model generates the behaviour parameters (flux and temperature) and of alloy composition. Quantitative agreement with the published experimental results (two compositions, three temperatures) is obtained with a single set of parameters. Modelling austenitic steels used in nuclear industry requires taking into account the contribution of dumbbells to mass transport. The effects of this latter contribution are studied on a model of Ni-Fe. Interstitial trapping on dilute impurities is shown to delay or even suppress the irradiation induced segregation. Such an effect is indeed observed in the experiments we report on Fe{sub 50}Ni{sub 50} and Fe{sub 49}Ni{sub 50}Hf{sub 1} alloys. (author). 190 refs.

  5. Déterminants moléculaires de la néphrotoxicité induite par le tacrolimus après transplantation rénale

    OpenAIRE

    Van Der Hauwaert , Cynthia

    2014-01-01

    Although widely prescribed in kidney transplantation, Tacrolimus use is limited by its nephrotoxic effects. Indeed, Tacrolimus contributes to the development of renal interstitial fibrosis lesions and tubular atrophy with a large variability between patients. Among the mechanisms involved in fibrogenesis, the epithelial-mesenchymal transition (EMT) has been proposed. EMT is a dynamic process by which a polarized epithelial cell loses its epithelial markers (E-cadherin, cytokeratin, membrane &...

  6. Channel flow induced by wall injection of fluid and particles; Ecoulement induit par injection parietale de fluide et de particules dans un conduit

    Energy Technology Data Exchange (ETDEWEB)

    Feraille, Th.; Casalis, G. [Aerodynamics and Energetics Modeling Dept., 31 - Toulouse (France)

    2003-12-01

    The Taylor flow is the laminar single phase flow induced by gas injection through porous walls, and is assumed to represent the flow inside solid propellant motors. Such a flow is intrinsically unstable, and the generated instabilities are probably responsible for the thrust oscillations observed in the aforesaid motors. However particles are embedded in the propellants usually used, and are released in the fluid by the lateral walls during the combustion, so that there are two heterogeneous phases in the flow. The purpose of this paper is to study the influence of these particles on stability by comparison with stability results from the single phase studies, in a plane two-dimensional configuration. The particles are supposed to be chemically inert and of a uniform size. In order to carry out a linear stability study for this flow modified by the presence of particles, the mean particle velocity field is first determined, assuming that only the gas exerts forces on the particles. This field is sought in a self similar form, which imposes a limit on the size of the particles. However, the particle mass concentration cannot be obtained in a self similar form, but can only, be described by a partial differential equation. The mean flow characteristics being determined, the spectrum of the discretized linear stability operator shows first that particle addition does not trigger any new 'dangerous' modes compared with the single phase flow case. It also shows that the most amplified mode in the case of the single phase flow remains the most amplified mode in the case of the two phase flow. Moreover, the addition of particles acts continuously upon stability results, behaving linearly with respect to the particle mass concentration when the latter is small. The linear correction to the monophasic mode, as well as the evolution of the modes with weak values of the particle mass concentration at the wall, are shown to be proportional to the ejection velocity of the particles. Then, the evolution of the Eigenmodes from a given injection speed of the particles to another one is deduced by affinity, all other parameters being fixed. With a fixed Stokes number, stability results for a finite Reynolds number and results for the inviscid flow bring together when augmenting the particle mass concentration at the wall. Therefore, by knowing single phase flow results and the evolution of stability characteristics of the two phase flow in the inviscid case, it it easy to determine whether particle-laden Taylor flow is more or less stable than the monophasic Taylor flow for large particle mass concentration. (authors)

  7. The hematopoietic syndrome induced by an accidental radiation: evaluation and treatments; Le syndrome h atopoietique induit par une irradiation accidentelle: evaluation et traitements possibles

    Energy Technology Data Exchange (ETDEWEB)

    Bertho, J.M. [Institut de Radioprotection et de Surete Nucleaire (IRSN/DRPH/SRBE), Lab. de Therapie Cellulaire et de Radioprotection Accidentelle 92 - Fontenay-aux-Roses (France)

    2006-04-15

    The accidental radiation-induced hematopoietic syndrome remains difficult to treat, mainly due to the heterogeneity of irradiation. As a result, there always remains an area of active hematopoiesis that was partly protected from irradiation. The choice of a therapeutic strategy must be based upon the estimate of radiation damage to the bone marrow. This can be achieved by the use of biological indicators of radiation dose or damage such as the follow up of Flt3 ligand concentration in the blood. The possible therapeutic strategies remain limited, either stem cell transplantation or supportive care. A new approach based upon autologous cell therapy was proposed and the results highlighted new insight about the radiation-induced multiple organ disease syndrome. Other recent results from our lab suggested that among the possible therapeutic strategies, the stimulation of residual hematopoiesis by the mean of cytokines such as G-CSF is one of the most interesting strategies. These new data highlight the notion of residual hematopoiesis but also the fact that regulation mechanisms of residual hematopoiesis are not well understood. (author)

  8. Mécanismes et fonctions de la voie d'ARN interférence induite par ARN double brin chez Paramecium tetraurelia

    OpenAIRE

    Carradec , Quentin

    2014-01-01

    The ciliate Paramecium tetraurelia is an interesting model to study the diversity and evolution of RNA interference (RNAi) pathways. One of the vegetative RNAi pathways is induced by feeding cells with bacteria producing double-stranded RNA (dsRNA) homologous to a given gene, which is then post-transcriptionally silenced through the production of 23-nt siRNAs. A forward genetic screen allowed us to obtain Mendelian mutants deficient in dsRNA-induced RNAi, and mutated genes were identified by ...

  9. Treatment of radioinduced skin burns by adult stem cells;Traitement des brulures cutanees radio-induites par cellules souches adultes

    Energy Technology Data Exchange (ETDEWEB)

    Lataillade, J.J.; Prat, M. [Hopital Militaire Percy, Centre de Transfusion Sanguine des Armees, Dept. Recherches et Therapies Cellulaires, 92 - Clamart (France); Gourmelon, P. [Institut de Radioprotection et de Surete Nucleaire (IRSN), 92 - Fontenay-aux-Roses (France); Bey, E. [Hopital Militaire Percy, Service de Chirurgie Plastique, 92 - Clamart (France)

    2009-12-15

    In the area of skin injuries caused by ionizing radiations; the recent opportunity give us the the possibility to manage victims of radiation accidents with skin acute symptoms of irradiation. The approach of cell therapy developed for these patients could be in a second time, used for other types of injuries as thermal burns and the injuries linked to overexposure in radiotherapy. In spite of the diversity of approaches of allogeneic and autologous transplantation, the prognosis of deep and extended radioinduced burns is not completely satisfying because of inflammatory recurrences, origin of graft failures. The stem cells have been used in association. The stem cells were got from sampling of autologous bone marrow after an expansion in vitro from 15 to 17 days. The cultures were realised in medium with 8% of platelet lysate (clinical grade). The cells have been given by injection in complement of epidermis auto graft. A spectacular effect was noticed the day after the injection, but disappearing in some days encouraging to realize supplementary injections. An effect of the quickness and the quality of the graft success is appeared significant too. no necrosis recurrence for the patients after four years for the first one of them. We think that the stem cells participate to the local control of inflammation. (N.C.)

  10. Study of the mechanisms induced by a ionizing particle on simple structures; Etude des mecanismes de base induits par une particule ionisante sur des structures simples

    Energy Technology Data Exchange (ETDEWEB)

    Hubert, G.; Palau, J.M.; Roche, Ph.; Sagnes, B.; Gasiot, J. [Montpellier-2 Univ., CEM2, 34 (France); Calvet, M.C. [Aerospatiale Espace et Defense, 78 - Les Muraux (France)

    1999-07-01

    Ion induced currents in a diode and a semiconductor bar are compared. A short track, located inside the structure, and a long track passing through it are considered. The involved mechanisms are analysed in order to explain why the observed effects are very similar. (authors)

  11. Le rôle majeur du canal potassique TREK-1 dans la protection neuronale induite par les oméga-3

    Directory of Open Access Journals (Sweden)

    Heurteaux Catherine

    2005-01-01

    Full Text Available The nutritional interest of polyunsaturated fatty acids from omega-3, that are mainly present in vegetal and fish oils is now validated by the scientific community. Their beneficial effects have first been reported in coronary heart diseases. Many neurological and chronic diseases are often related to deficiencies in omega-3 and omega-6 and their derivatives. Polyunsaturated fatty acids from omega-3 family are essential to brain growth and neuronal preserving (foetuses, children, old people as well as visual and cognitive functions. They are recently considered as factors of improvement in some mental diseases. Today, polyunsaturated fatty acids could play a key role in the prevention and/or or the treatment of cerebral diseases. With the development of in vitro and in vivo experimental models, it is now possible to demonstrate the omega-3-induced neuronal protection against major pathologies such as epileptic seizures and cerebral ischemia. The molecular mechanism of neuronal protection induced by omega-3 is now clarified. The omega-3 target would be a potassium channel, TREK-1, which belongs to the new family of 2-P domain potassium channels (K-2P. The discovery of the physiopathological role of these K-2P channels can represent an important therapeutical challenge not only in cerebrovascular diseases, but also in psychiatry.

  12. Swift heavy ion irradiation effects in {alpha} poly(vinylidene fluoride); Etude des effets induits par les ions lourds energetiques dans le poly(fluorure de vinylidene)

    Energy Technology Data Exchange (ETDEWEB)

    Le Bouedec, A

    1999-11-29

    The goal of this study is to characteristic and to localised defects created in {alpha} Poly (vinylidene fluoride) after swift heavy ion irradiations. PVDF films are irradiated with several Swift Heavy Ions (SHI), in the electronic stopping power (dE/dx){sub e}, in order to study the influence of irradiation parameters (absorbed dose, ion). These irradiated films are studied by different analysis techniques such as FTIR, ESR (X and Q band) spectroscopies and DSC. The crystalline level of PVDF is about 50% and we follow it destruction and amorphization as the absorbed dose increase by DSC and FTIR studies. The variation of the various FTIR bands allow us to observe the unsaturations induced by SHI radiations. Two sets of defects are observed: those which yield is sensitive to an increase of (dE/dx){sub e} and those that are not. A spatial distribution of the various defects within the talent track is provided and defects that are difficult to create are the closest of the ion path. The different kind of radicals created after irradiations are studied by ESR spectroscopy. Alkyl, peroxy and polyenyl radicals are detected after SHI radiations like after electron or {gamma} irradiations. Their yield of creation is independent of (dE/dx){sub e} and their localised in the crystalline zone or/and at the interfacial zone between crystalline and amorphous one. An other kind of radicals is created only after SHI radiations that are specific of the SHI-polymer interaction. We observe that these radicals are localised on a carbon cluster, in the core of the latent track for low doses and highly sensitive at the (dE/dx){sub e} of the ion. (author)

  13. Étude des dommages induits dans l'ADN par irradiation laser X-UV à 21.2 nm

    Science.gov (United States)

    Cassou, K.; Ros, D.; Kazamias, S.; Klisnick, A.; Jamelot, G.; Guilbaud, O.; Rus, B.; Kozlová, M.; Polan, J.; Präg, A. R.; Stupka, M.; Eot-Houllier, G.; Sage, E.; Begusová, M.; Stísová, V.; Du Penhoat, M.-A. H.; Touati, A.; Chétioui, A.

    2005-06-01

    We report the preliminary result of the application of the collisional Ne-like soft x-ray laser as radiation source to induce DNA damage. The goal of this experiment was a test bed study of the damage yields induced by soft x-ray radiation in dried plasmid DNA sample. The saturated Ne-like soft x-ray laser available at the PALS facility, delivering several millijoules in a single 100 ps pulse at 21.2 nm was used to irradiate two different plasmids: pSP189 and pBS. The study is centered on the dose effect leading to single and double strand break in DNA.

  14. Caractéristiques moléculaires de l'immunité des plantes induite par les rhizobactéries non pathogènes

    Directory of Open Access Journals (Sweden)

    Thonart P.

    2008-01-01

    Full Text Available Molecular characteristics of the rhizobacteria-triggered plant immunity. Recognition of certain non-pathogenic rhizobacteria by plants can trigger a systemic resistance reaction that renders the host less susceptible to subsequent infection by a virulent agent. Used in combination with other approaches, this induced systemic resistance (ISR phenomenon is considered as a promising strategy for plant disease control both in greenhouse cultures and under field conditions. This review emphasizes the molecular aspects of this three-step process involving sequentially the perception by plant cells of elicitors produced by the inducing agents that initiates the phenomenon, signal transduction that is needed to propagate the induced state systemically through the plant and expression of defense mechanisms sensu stricto that limit or inhibit pathogen penetration into the host tissues. The current state of knowledge about rhizobacteria-stimulated ISR is discussed in parallel with the better characterized systemic acquired resistance induced by incompatible pathogens.

  15. L'analyse par activation de neutrons de réacteur

    Science.gov (United States)

    Meyer, G.

    2003-02-01

    Quand les neutrons traversent la matière, certains sont transmis sans interaction, les autres interagissent avec le milieu traversé par diffusion et par absorption. Ce phénomène d'absorption est utilisé pour se protéger des neutrons, mais aussi pour les détecter; il peut également être utilisé pour identifier les noyaux “absorbants" et ainsi analyser le milieu traversé. En effet par différentes réactions nucléaires (n,γ), (n,p), (n,α), (n,fission), on obtient des noyaux résiduels qui sont souvent radioactifs; on dit que l'échantillon est “activé". Si l'on connaît le rendement d'activation et donc le pourcentage de noyaux ainsi “transmutés", les mesures de radioactivité induite vont permettre de déterminer la composition de l'échantillon irradié. Cette méthode dite d'analyse par activation neutronique est pratiquée depuis la découverte du neutron. Elle a permis grâce à sa sélectivité et à sa sensibilité d'avoir accès au domaine des traces et des ultra-traces dans des champs d'application très divers comme la métallurgie, l'archéologie, la biologie, la géochimie etc...

  16. Parasitosis intestinales en poblaciones Mbyá-Guaraní de la Provincia de Misiones, Argentina: aspectos epidemiológicos y nutricionales Intestinal parasitosis in Mbyá-Guaraní populations from Misiones Province, Argentina: epidemiological and nutritional aspects

    Directory of Open Access Journals (Sweden)

    Graciela Teresa Navone

    2006-05-01

    Full Text Available Se describieron las enteroparasitosis más frecuentes en dos comunidades Mbyá-Guaraní de Misiones, Argentina: Kaaguy Poty e Yvy Pytá. Las parasitosis intestinales se asociaron con el estado nutricional de los individuos infectados y los factores ambientales y culturales que caracterizan a las poblaciones estudiadas. Los resultados se compararon con los obtenidos en una población aborigen vecina, Takuapí, y la población urbana más cercana: Aristóbulo del Valle. Se utilizaron las técnicas de Ritchie, Willis y Kato Katz para las muestras fecales. Se analizaron los parámetros antropométricos y se procesaron muestras de tierra. De un total 296 individuos en las cuarto poblaciones, 100 (87,7%, 63 (88,7%, 49 (96,1% y 50 (82% estuvieron parasitados en Kaaguy Poty, Yvy Pytá, Takuapí, y Aristóbulo del Valle respectivamente. El 84% de los individuos parasitados estuvieron poliparasitados. El 43% de los individuos medidos presentaron desnutrición y el 87% de ellos estaban parasitados. Hubo asociación entre el uso de letrinas y Giardia lamblia (p Intestinal parasite infestation in indigenous Mbyá-Guaraní communities in Misiones, Argentina, was described and associated with nutritional status and environmental and cultural factors. The results were compared with those from Takuapí, a neighboring indigenous population, and the nearest urban population, Aristóbulo del Valle. The Ritchie, Willis, and Kato Katz techniques were used to analyze the stool samples. Anthropometric parameters were analyzed and earth samples processed. From a total sample of 296 individuals analyzed in the four populations, 100 (87.7%, 63 (88.7%, 49 (96.1%, and 50 (82% were infested in Kaaguy Poty, Yvy Pytá, Takuapí, and Aristóbulo del Valle, respectively. 84% of infested individuals had multiple parasites. The 43% of the individuals presented malnutrition, and 87% of these were infested. There was an association between use of latrines and Giardia lamblia (p < 0

  17. Application of the laser induced fluorescence to the investigation of highly magnetized plasmas, heated by ion cyclotron resonance; Fluorescence induite par laser sur des plasmas fortement magnetises, chauffes par resonnance cyclotron ionique

    Energy Technology Data Exchange (ETDEWEB)

    Pailloux, A. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. des Procedes d`Enrichissement]|[Universite Louis Pasteur, 67 - Strasbourg (France)

    1997-12-31

    This work has been achieved in the frame of isotopic separation studies by in cyclotron resonance. For this purpose, in a highly magnetized (2 to 3 Tesla) and non-collisional (10{sup 12} ions/cm{sup 3}) plasma, composed of metallic ions, a wave near the ion cyclotron frequency is thrown in order to heat selectively a given species. A laser induced fluorescence (LIP) has been developed on barium and gadolinium plasmas. The Larmor gyration of ions greatly modifies the interaction, which has been modelled through the time-dependent Schroedinger equation. The obtained excitation probably has been integrated over all the ions excited in the measurement volume in order to check that the LIF still leads to the distribution function of ion velocities. The influence of the Larmor motion of ions on the spectral distribution of LIF has been derived both theoretically and experimentally. The LIF diagnostics has been achieved with a dye O`ring laser. The barium ion has been excited on the transition 6142 angstrom, using rhodamine 6G dye, and the gadolinium ion on the pseudo-triplet 3861 angstrom, using exalite dye. Data treatment has been developed taking into account the Zeeman effect and the different heating of isotopes. The ionic temperature (from 1 eV to some hundreds eV) has been measured as a function of radiofrequency heating. Our experimental results are in good agreement with the selective heating theory. Also, the ion velocity distribution function has been found locally Maxwellian. And the behaviour of the plasma has been studied as a function of control parameters of the plasma source. (author) 62 refs.

  18. Study of the production of neutron-rich isotope beams issuing from fissions induced by fast neutrons; Etude de la production de faisceaux riches en neutrons par fission induite par neutrons rapides

    Energy Technology Data Exchange (ETDEWEB)

    Lau, Ch

    2000-09-15

    This work is a contribution to the PARRNe project (production of radioactive neutron-rich isotopes). This project is based on the fission fragments coming from the fission of 238-uranium induced by fast neutrons. The fast neutron flux is produced by the collisions of deutons in a converter. Thick targets of uranium carbide and liquid uranium targets have been designed in order to allow a quick release of fission fragments. A device, able to trap on a cryogenic thimble rare gas released by the target, has allowed the production of radioactive nuclei whose half-life is about 1 second. This installation has been settled to different deuton accelerators in the framework of the European collaboration SPIRAL-2. A calibration experiment has proved the feasibility of fixing an ISOL-type isotope separator to a 15 MV tandem accelerator, this installation can provide 500 nA deutons beams whose energy is 26 MeV and be a valuable tool for studying fast-neutron induced fission. Zinc, krypton, rubidium, cadmium, iodine, xenon and cesium beams have been produced in this installation. The most intense beams reach 10000 nuclei by micro-coulomb for 26 MeV deutons. An extra gain of 2 magnitude orders can be obtained by using a more specific ion source and by increasing the thickness of the target. Another extra gain of 2 magnitude orders involves 100 MeV deutons.

  19. suPAR: the molecular crystal ball

    DEFF Research Database (Denmark)

    Thunø, Maria; Macho, Betina; Eugen-Olsen, Jesper

    2009-01-01

    soluble urokinase Plasminogen Activator Receptor (suPAR) levels reflect inflammation and elevated suPAR levels are found in several infectious diseases and cancer. suPAR exists in three forms; suPAR(I-III), suPAR(II-III) and suPAR(I) which show different properties due to structural differences. ...

  20. Contribution to the study of detonation initiation by shock in solid explosives (1961); Contribution a l'etude de l'initiation de la detonation par choc dans les explosifs solides (1961)

    Energy Technology Data Exchange (ETDEWEB)

    Fauquignon, C. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1961-05-15

    When a shock wave is induced in an explosive, it can initiate chemical reactions which lead more or less rapidly to a stable detonation state. In this study more particular attention was paid to the transition phase, in which has been evaluated the increases in the wave velocity, the pressure, and the electrical conductivity. The influence of the nature of the medium in front of the wave and in contact with the explosive has also been the subject of an experimental study designed to determine the extent to which its nature can be ignored and, subsequently, to characterise the initiation conditions using only the shock intensity induced in the explosive. Finally, the results were generalized for various explosive compositions and led to the development of a possible mechanism for shock initiation. (author) [French] Lorsqu'une onde de choc est induite dans un explosif, elle peut y amorcer des reactions chimiques qui conduisent plus ou moins rapidement a un regime de detonation stable. Dans cette etude, on s'est interesse plus particulierement a la phase transitoire dans laquelle on a evalue l'accroissement de la vitesse d'onde, de la pression et de la conductibilite electrique. L'influence du milieu amont, au contact de l'explosif, a egalement fait l'objet de recherches experimentales de facon a determiner dans quelle mesure on pouvait s'affranchir de sa nature et, par suite, caracteriser les conditions d'initiation par la seule intensite du choc induit dans l'explosif. Enfin, les resultats ont ete generalises a diverses compositions explosives et ont conduit a l'elaboration d'un schema possible du mecanisme de l'initiation par choc. (auteur)

  1. Parálisis cerebral :

    OpenAIRE

    Giral Lamenca, Mónica

    2015-01-01

    Se aborda el tema de la parálisis cerebral definiendo qué es, clasificando los tipos de parálisis dependiendo de la afectación y las características principales. Se explican algunos de sus tratamientos, se dan sistemas alternativos y/o aumentativos de comunicación para un alumno con PC (parálisis cerebral).

  2. Radioinduced intestinal fibrosis: from molecular mechanisms to therapy applications. Contribution of the TGF--{beta}1, of the CTGF and of the transduction pathway of the Rho/ROCK signal; La fibrose intestinale radio-induite: des mecanismes moleculaires aux applications therapeutiques. Roles du TGF-{beta}1, du CTGF et de la voie de transduction du signal Rho/ROCK

    Energy Technology Data Exchange (ETDEWEB)

    Haydont, V

    2006-12-15

    Delayed radiation enteritis is an intestinal fibrosis induced by accidental or therapeutic radiation for pelvic and abdominal cancer treatments. Studies of molecular mechanisms involved in the development and maintenance of fibrosis have showed the respective contribution of CTGF, low TGF-{beta}1 concentrations and Rho/ROCK pathway. Thus, based on the relationship between CTGF, TGF-{beta}1 and Rho pathway, 2 therapeutics strategies have been develop. First, a pravastatin curative gift leads to a fibro-lysis involving an inhibition of Rho and in cascade a reduction of CTGF expression and extracellular matrix deposition. The data suggest that reversal of established radiation fibrosis in the gut is possible. Second, a pravastatin prophylactic gift prevents the installation of a chronic fibrosis but does not protect the tumor. On the base of these results, the radiation therapy department of the Institut Gustave Roussy will soon initiate 2 clinical trials. (author)

  3. Prevalencia de microsporidios intestinales y otros enteroparásitos en pacientes con VIH positivo de Maracaibo, Venezuela

    OpenAIRE

    Zulbey Rivero-Rodríguez; Amparo Hernández; Ángela Bracho; Solneumar Salazar; Rafael Villalobos

    2013-01-01

    Introducción. Desde 1985, los microsporidios se consideran parásitos causantes de infecciones emergentes y oportunistas en individuos inmunocomprometidos en todo el mundo. Objetivo. Detectar la presencia de microsporidios y otros enteroparásitos en pacientes con VIH/sida del Servicio Autónomo Hospital Universitario de Maracaibo (SAHUM), donde no existían estudios previos en este campo. Materiales y métodos. Las muestras fecales se analizaron mediante examen directo, método de concentr...

  4. Physique et modélisation d’interactions instationnaires onde de choc/couche limite autour de profils d’aile transsoniques par simulation numérique

    OpenAIRE

    Grossi, Fernando

    2014-01-01

    L’interaction onde de choc/couche limite en écoulement transsonique autour de profils aérodynamiques est étudiée numériquement utilisant différentes classes de modélisation de la turbulence. Les approches utilisées sont celles de modèles URANS et de méthodes hybrides RANS-LES. L’emploi d’une correction de compressibilité pour les fermetures à une équation est aussi évalué. Premièrement, la séparation intermittente induite par le choc sur un profil supercritique en conditions d’incidence proc...

  5. Datation par thermoluminescence

    Directory of Open Access Journals (Sweden)

    1976-01-01

    Full Text Available Depuis 1953, de nombreux chercheurs se sont intéressés à la datation par thermoluminescence de minéraux anciennement brûlés ou cuits. Dans ce travail, après avoir rappelé quelques principes physiques de la thermoluminescence, on présente cette méthode de datation en mettant l'accent sur le mécanisme thermoluminescent dans une poterie. Ainsi la dose d'irradiation reçue par le matériau étant proportionnelle au temps écoulé depuis le 'zéro archéologique', il est possible de déterminer 'la dose archéologique' et d'en déduire l'âge de l'échantillon après avoir calculé la dose d'irradiation annuelle. La réalisation pratique d'un tel ensemble de mesure est cependant très ardue. Dans un prochain article, E. A. Decamps et A. Roman montreront des résultats relatifs à la thermoluminescence d'échantillons de quartz naturels, purs et dopés et la mise au point d'une nouvelle méthode de datation. Desde 1953, muchos investigadores se han interesado en la datación por termoluminiscencia de minerales antiguamente quemados o cocidos. Dentro de este trabajo, luego de haber recordado algunos principios físicos de la termoluminiscencia, se presenta este método de datación poniendo mayor atención en el mecanismo termoluminescente en una vasija de metal o de barro. Siendo proporcional la dosis de irradiación recibida al tiempo transcurrido desde el 'cero arqueológico', es posible determinar 'la dosis arqueológica', y deducir la edad de la muestra luego de haber calculado la dosis de irradiación anual. La realización práctica de un trabajo de tal dimensión es sin embargo muy ardua. En un próximo artículo, E. A. Decamps y A. Román presentarán los resultados relativos a la termoluminiscencia de muestras de cuarzo naturales, puras y dopadas y la elaboración de un nuevo método de datación. Since 1953, a number of scientists have been concerned with the use of thermoluminescence for the dating of burned or fired minerals

  6. Prevalencia de microsporidios intestinales y otros enteroparásitos en pacientes con VIH positivo de Maracaibo, Venezuela

    Directory of Open Access Journals (Sweden)

    Zulbey Rivero-Rodríguez

    2013-12-01

    Full Text Available Introducción. Desde 1985, los microsporidios se consideran parásitos causantes de infecciones emergentes y oportunistas en individuos inmunocomprometidos en todo el mundo. Objetivo. Detectar la presencia de microsporidios y otros enteroparásitos en pacientes con VIH/sida del Servicio Autónomo Hospital Universitario de Maracaibo (SAHUM, donde no existían estudios previos en este campo. Materiales y métodos. Las muestras fecales se analizaron mediante examen directo, método de concentración con formol-éter, coloración de Kinyoun y coloración Gram-cromotropo rápida. Se realizaron PCR separadas para diferenciar Entamoeba histolytica o Entamoeba dispar, cuando se observó el complejo E. histolytica/dispar al microscopio. Mediante historia clínica se obtuvo información del paciente. Resultados. De los 56 individuos participantes, 38 (67,86 % presentaron alguna especie parasitaria comensal o patógena en su muestra fecal. Predominaron los individuos portadores de especies parásitas patógenas (26/38. Fueron diagnosticados protozoos como Isospora belli (17,65 %, Blastocystis spp. (17,65 %, Cryptosporidium spp. (7,84 %, complejo Entamoeba histolytica/dispar (5,88 %, Entamoeba coli (3,92 %, Giardia lamblia (3,92 %, Endolimax nana (3,92 %, Cyclospora cayetanensis (3,92 % y Chilomastix mesnili (1,96 %. Entre los helmintos, Ascaris lumbricoides, Trichuris trichiura y Strongyloides stercoralis, presentaron un porcentaje de 27,27 % cada uno, e Hymenolepis nana, de 18,18 %. Solo se detectó E. histolytica en uno de los tres casos que presentaron el complejo al examen microscópico. Mediante Gram-cromotropo, 17 muestras evidenciaron esporas del filo Microsporidia, lo que equivale a un 33,33 % de prevalencia. Conclusión. Los microsporidios pueden ocupar el primer lugar de prevalencia en pacientes con VIH positivo, cuando se utilizan técnicas diagnósticas específicas.   doi: http://dx.doi.org/10.7705/biomedica.v33i4.1468

  7. Le déficit immunitaire commun variable à révélation tardive par des manifestations digestives: à propos d’un cas

    Science.gov (United States)

    Ezzaitouni, Fatima; Thiyfa, Youssef; Tahiri, Mohamed; Haddad, Fouad; Hliwa, Wafaa; Bellabah, Ahmed; Badre, Wafaa

    2017-01-01

    Le déficit immunitaire commun variable (DICV) est une pathologie rare, il s’agit d’un déficit constitutionnel de l'immunité humorale caractérisé par des infections bactériennes à répétition, et par une fréquence accrue de tumeurs, de maladies auto-immunes ou granulomateuses. Les manifestations gastro-intestinales sont très variables et parfois révélatrices d’un déficit immunitaire commun variable. Nous rapportons le cas d’un patient âgé de 31 ans, ayant comme antécédent des infections respiratoires à répétition depuis le bas âge, compliquées d’une dilatation des bronches, qui présente depuis 3 ans une diarrhée glaireuse récurrente, chez qui l’ensemble du bilan étiologique est en faveur d’un DICV avec une manifestation auto-immune (vitiligo). Le traitement a consisté en une perfusion mensuelle d’immunoglobulines (Ig) avec une bonne évolution. Le recul actuel est de deux ans. PMID:29184600

  8. Parasitosis intestinales y factores socio-sanitarios en niños del área rural del distrito de Los Baños del Inca, Cajamarca-Perú

    OpenAIRE

    Rodríguez-Ulloa, Claudia; Rivera-Jacinto, Marco; Saucedo-Duran, Edith; Rojas-Huamán, Yessica; Valdivia-Meléndez, Nayeli; Cabanillas-Vásquez, Quely; Blanco-Burga, Hebert

    2011-01-01

    Sr. Editor: La parasitosis intestinal, de alta incidencia en los niños, es un importante problema de salud pública en Cajamarca, y agrupadas dentro de las enfermedades infecciosas intestinales constituyen una de las diez primeras causas de morbilidad y de mortalidad en este grupo poblacional (1). La alta ruralidad de la región cajamarquina es favorable, desde el punto de vista epidemiológico, socioeconómico y ecológico, para que los niños adquieran infecciones parasitarias con mayor frecuenci...

  9. Mecanismos moleculares implicados en el efecto protector de los polifenoles de la dieta frente al estrés oxidativo y la inflamación: estudio en células intestinales y animales de experimentación

    OpenAIRE

    Rodríguez Ramiro, Ildefonso

    2012-01-01

    El estrés oxidativo parece ser una de las causas implicadas en el origen de numerosas patologías y enfermedades intestinales. Los desequilibrios redox producidos en la mucosa intestinal pueden dar lugar a daños oxidativos y a una disfunción en las vías de señalización celular iniciando diversos procesos patológicos. En los últimos años la prevención nutricional de las enfermedades ha empezado a tomar una gran importancia. Así, ha surgido un gran interés por investigar los efectos biológ...

  10. Participación comunitaria en el control de las parasitosis intestinales en una localidad rural de Argentina Community participation in the control of intestinal parasitoses at a rural site in Argentina

    OpenAIRE

    Betina C. Pezzani; Marta C. Minvielle; María L. Ciarmela; María C. Apezteguía; Juan A. Basualdo

    2009-01-01

    OBJETIVOS: Diseñar, implementar y evaluar un plan complejo de acciones dirigido a reducir las parasitosis en una localidad rural de la provincia de Buenos Aires, Argentina, con la participación de la comunidad. MÉTODOS: El trabajo se realizó en General Mansilla, provincia de Buenos Aires, Argentina, en tres etapas. 1) Se evaluó la situación epidemiológica inicial de las parasitosis intestinales en la comunidad mediante análisis coproparasitológico seriado y de escobillado anal en una muestra ...

  11. UTILITATEA UNOR GENURI DE BACTERII INTESTINALE ŞI SEMNIFICAŢIA LOR ÎN SĂNĂTĂTEA ORGANISMULUI

    Directory of Open Access Journals (Sweden)

    Maria TIMOŞCO

    2017-03-01

    Full Text Available În cadrul investigaţiilor ce vizează izolarea şi identificarea monotulpinilor de lactobacterii intestinale s-a constatat că acestea reprezintă lactobacterii în diversă formă (bacili şi coci ce aparţin familiilor Lactobailliaceae şi Streptococcaceae şi genurilor: Lactobacillus (33,29%, Lactococcus (19,32%, Streptococcus (22,51% şi Enterococcus (24,86%. Conform activităţii antagoniste şi  capacităţii adezive sporite, acestea au demonstrat utilitate esenţială pentru organism. Cercetările în experimente model (pe purcei sugari au depistat deosebire esenţială între nivelul cantitativ şi calitativ al bacteriilor din genurile Lactobacillus şi Enterococcus la animale cu simptome de disfuncţii diareice (diminuare cu 22,46, 26,71 şi 22,44% şi creştere cu 20,50, 18,47 şi 16,86% respectiv vârstei de 7, 15 şi 30 de zile, comparativ cu cele sănătoase. Concomitent, s-a dovedit că mărirea numărului de enterococi a avut caracter diferenţiat, pentru că s-a evidenţiat creştere numai la specia de Enterococcus fecalis, iar la specia Enterococcus faecium – diminuare. Prin aceasta s-a confirmat opinia despre rolul semnificativ al  lactobacteriilor în sănătatea organismului, deoarece în cazul patologiei intestinale are loc diminuarea cantitativă a celor cu proprietăţi utile şi sporirea celor de categorie condiţionat patogenă.THE UTILITY SOME GENERES OF GUT BACTERIA AND THEIR SIGNIFICANCE IN THE ORGANISM HEALTHThe studies directed of isolation and to identify mono strains of intestinal lactobacteria have found these represent lactobacteria in diverse form (bacilli and cocci that belong families Lactobailliaceae and Streptococcaceae and genres: Lactobacillus (33,29%, Lactococcus (19,32%, Streptococcus (22,51% and Enterococcus (24,86%. According antagonistic activity and greater adhesive capacities they demonstrated essential utility for the organism. Research in model experiments (the piglets detected essential

  12. Dinámica para la identificación de las formas parasitarias microscópicas de los geohelmintos intestinales

    Directory of Open Access Journals (Sweden)

    Rebeca Margarita Laird Pérez

    2015-11-01

    Full Text Available Las estadísticas sobre geohelmintos intestinales, a partir del examen parasitológico de las heces, constituye la espina dorsal de los programas para el control de estos gusanos, pues a partir de ellas se obtiene información útil para la toma de decisiones; no obstante, existen insuficiencias cognoscitivas y en las habilidades para la identificación de formas microscópicas de geohelmintos por parte del personal del laboratorio, así como deficiencias didácticas en el abordaje bibliográfico sobre aspectos de interés para la identificación parasitaria, lo cual contribuye al reporte de errores en el laboratorio. Con vistas a contribuir al mejor diagnóstico de estos agentes parasitarios se elaboró el presente artículo, en el período de enero a marzo de 2013. Se realizó una amplia revisión bibliográfica y se diseñó una dinámica de identificación con énfasis en los detalles morfo-biológicos. Se concluye en la importancia del estudio del número y características de las cubiertas y contenido ovular en los inconvenientes de reportar las especies del género Trichuris, si no se emplean oculares micrométricos, en la utilidad de considerar la posible presencia de especies antropozoonóticas y de realizar el diagnóstico diferencial con los huevos y las larvas de otros helmintos presentes en las heces, con los que se comparten similitudes morfológicas.

  13. The ParB-parS Chromosome Segregation System Modulates Competence Development in Streptococcus pneumoniae

    NARCIS (Netherlands)

    Attaiech, Laetitia; Minnen, Anita; Kjos, Morten; Gruber, Stephan; Veening, Jan-Willem

    UNLABELLED: ParB proteins bind centromere-like DNA sequences called parS sites and are involved in plasmid and chromosome segregation in bacteria. We previously showed that the opportunistic human pathogen Streptococcus pneumoniae contains four parS sequences located close to the origin of

  14. Propriétés structurales et électrochimiques de couches minces de V2O5 élaborées par dépôt chimique de couches atomiques en phase vapeur (ALCVD)

    Science.gov (United States)

    Mantoux, A.; Badot, J.-C.; Baffier, N.; Farcy, J.; Pereira-Ramos, J.-P.; Lincot, D.; Groult, H.

    2002-04-01

    Les couches minces de V2O5 ont été élaborées par dépôt chimique de couches atomiques en phase vapeur (ALCVD). La diffraction des rayons X a mis en évidence le phénomène d'orientation préférentielle selon l'axe cristallographique c de V2O5 déposé sur le substrat titane. La microscopie électronique à transmission a permis de visualiser un grain de V2O5 ainsi que l'interface avec le substrat. La spectroscopie de photoélectrons induits par rayons X a permis de montrer que les couches directement issues de la synthèse par ALCVD (sans recuit ultérieur) sont partiellement réduites, de l'ordre de 10 % de V^{4+} en surface. Les mesures électrochimiques ont montré que les couches minces de V2O5, obtenues sur le support titane, étaient de très bonne qualité en terme de réversibilité, de cyclabilité et de bilan faradique (0,92 F/mol pour un potentiel d'arrêt de 3 volts et 1,6 F/mol pour un potentiel d'arrêt de 2,2 volts vs Li/Li^+).

  15. Vision par ordinateur: outils fondamentaux

    OpenAIRE

    Horaud, Radu; Monga, Olivier

    1995-01-01

    National audience; Cet ouvrage présente les outils fondamentaux de la vision par ordinateur dans un langage mathématique accessible aux étudiants de niveau DEUG en mathématiques ou informatique. Il donne également de nombreux exemples d'utilisation de la vision par ordinateur dans deux domaines de technologie de pointe : la robotique et l'imagerie médicale. Cette deuxième édition largement augmentée est un manuel de référence. Les outils fondamentaux sont présentés dans un langage mathématiqu...

  16. The determination of iodine in biological media using radioactivation analysis (1962); Dosage de l'iode dans les milieux biologiques au moyen de l'analyse par radioactivation (1962)

    Energy Technology Data Exchange (ETDEWEB)

    Comar, D. [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

    1962-06-15

    The object of this study is to show that the application of radioactivation analysis to the determination of iodine in biological media makes it possible to measure iodine concentrations of the order of 0.0001 {mu}g. After a review of the chemical methods with a mention of the difficulties they present, the optimum conditions for the determination of iodine in biological liquids are given. Three methods are described: - the first consists of a chemical treatment which liberates the protein bound iodine in an inorganic form. After distillation this iodine is irradiated in a flux of thermal neutrons. The induced radioactivity is compared to that of a standard sample irradiated in the same conditions by {gamma} spectrometry. - the second method which is of more general application consists in irradiating the sample and then extracting the iodine; its induced radio-activity is then measured by {beta}-counting. - the third method measures the iodine directly in the thyroid tissue by anti-compton spectrometry. The sensitivity, the reproducibility and the accuracy are discussed. Some applications are described: determination of iodine in its various organic forms in serum, determination of iodine in urines, in food-stuffs, etc., in the thyroid tissue, etc. (author) [French] Le but de cette etude est de montrer que l'analyse par radioactivation appliquee au dosage de l'iode dans les milieux biologiques permet de mesurer des taux d'iode de l'ordie de 0,0001 {mu}g. Apres avoir rappele le principe des methodes chimiques et montre les difficultes de leur mise en oeuvre, il est etabli les conditions optima pour realiser le dosage de l'iode dans les liquides biologiques. Trois methodes sont decrites; - la premiere consiste a pratiquer un traitement chimique liberant l'iode proteique sous forme minerale. Apres distillation cet iode est irradie dans un flux de neutrons thermiques. La radioactivite induite est mesuree comparativement a celle d

  17. Some applications of neutron activation analysis in plant biology and agronomy; Quelques applications de l'analyse par radioactivation neutronique en biologie vegetale et en agronomie

    Energy Technology Data Exchange (ETDEWEB)

    Fourcy, A. [Commissariat a l' Energie Atomique, Grenoble (France). Centre d' Etudes Nucleaires

    1966-06-01

    Plants materials are not so commonly analysed by radioactivation than biological extracts of medical importance. With help of concrete examples, applications of neutrons activation analysis to the determination of some metals (Mn, Cu, Co, Fe, Zn, and K) in plant materials, are proposed. Samples are activated in a swimming-pool reactor at the thermal flux of 5.10{sup 12} n.cm{sup -2}s{sup -1} for a time varying between few minutes and several days according to the element being analysed. The induced radioactivity is measured by spectrometry, with radiochemical separation ( Cu, Co, Fe, Zn and K) or without separation in best cases (Mn,Cu, K). Described dosages are related to: manganese in a graminaceous plant, copper in vine treatments, cobalt, iron and zinc in animal feeding, potassium in a radiological experiment. (author) [French] Les produits vegetaux sont beaucoup moins souvent soumis a l'analyse par activation que les extraits biologiques d'interet medical. En s'appuyant sur des cas concrets, nous proposons des applications de l'analyse par activation neutronique au dosage de differents metaux (Mn, Cu, Co, Fe, Zn, et K) dans la matiere vegetale. Les echantillons sont actives en pile piscine au flux thermique de 5.10{sup 12} n.cm{sup -2} s{sup -1} pendant des temps variant de quelques minutes a plusieurs jours selon les elements a analyser. le comptage de la radioactivite induite est effectue par spectrometrie gamma apres separation radiochimique (Cu, Co, Fe, Zn, et K) ou sans separation dans les cas favorables (Mn, Cu, K). Les dosages decrits concernent: le manganese dans une graminee, le cuivre en viticulture, le cobalt, le fer, et le zinc dans un aliment du betail, le potassium dans une experience de radioecologie. (auteur)

  18. Par Pond Fish, Water, and Sediment Chemistry

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond.

  19. Par Pond Fish, Water, and Sediment Chemistry

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-06-01

    The objectives of this report are to describe the Par Pond fish community and the impact of the drawdown and refill on the community, describe contaminant levels in Par Pond fish, sediments, and water and indicate how contaminant concentrations and distributions were affected by the drawdown and refill, and predict possible effects of future water level fluctuations in Par Pond

  20. Ionisation and dissociation of water induced by swift multicharged ions; Etude de l'ionisation et de la dissociation d'H{sub 2}O induites par collision avec des ions multicharges rapides

    Energy Technology Data Exchange (ETDEWEB)

    Legendre, S

    2006-02-15

    Ionization and dissociation of water molecules and water clusters induced by 11.7 MeV/A Ni{sup 25+} ions were carried out by imaging techniques. Branching ratios, ionisation cross sections and Kinetic Energy Released distributions have been measured together with fragmentation dynamics studies. Multiple ionization represents approximately 30% of the ionizing events. Double ionization produces in significant way atomic oxygen, considered as a possible precursor of the large production of HO{sub 2} radical in liquid water radiolysis by ions of high Linear Energy Transfer. We evidence a strong selectivity of bond breakage in the case of ion-induced HOD fragmentation. Once the molecule doubly ionized, the breakage of the O-H bond is found 6.5 times more probable than that of the O-D bond. A semi-classical calculation simulating the fragmentation dynamics on the potential energy surface of the ground-state of di-cation H{sub 2}O{sup 2+} makes possible to as well reproduce the preferential nature of the breakage of the O-H bond as the position and the shift of the kinetic energy distributions. First results concerning interaction with water clusters are also reported. Measurements in coincidence are carried out giving access to correlation, with the distributions in energy and angle of the emitted fragments. Mass spectrum points fast intra-cluster proton transfer, leading to the emission of protonated clusters. (author)

  1. Electron emission following collisions between multi-charged ions and D{sub 2} molecules; Etude de l'emission electronique induite par impact d'ion multicharge sur la molecule D{sub 2}

    Energy Technology Data Exchange (ETDEWEB)

    Laurent, G

    2004-05-15

    Dissociative ionisation mechanisms induced in collisions involving a highly charged ion (S{sup 15+}, 13.6 MeV/u) and a molecular deuterium target, have been studied through momentum vector correlations of both the D{sup +} fragments and the electrons produced. An experimental apparatus has been developed in order to detect in coincidence all the charged particles produced during the collision. The measurement of their momentum vectors, which allows one to determine both their kinetic energy and direction of emission with respect to the projectile one, combines Time of Flight, Position Sensitive Detection, and multi-coincidence techniques. The correlation of the fragment and electron kinetic energies enables not only to determine branching ratios between the dissociative ionisation pathways, but also to separate unambiguously kinetic energy distributions of fragments associated to each process. Finally, the angular distributions of ejected electrons, as a function of the orientation of the molecular axis with respect to the projectile direction, are deduced from the spatial correlation. Measurements are compared to theoretical angular distributions obtained using the CDW-EIS (Continuum Distorted Wave-Eikonal Initial State) method. (author)

  2. Pathologies des hélicases et vieillissement précoce : modèle d'étude par dérivation de cellules souches pluripotentes induites (iPS)

    OpenAIRE

    Gatinois , Vincent

    2017-01-01

    Helicases process the double-stranded DNA dissociation. They are involved in replication, DNA repair and maintenance of telomeres. In human, 3 helicases display mutations responsible for clinical syndromes: WRN for the Werner syndrome, BLM for the Bloom syndrome and RECQL4 for the Rothmund-Thomson syndrome. All these diseases cause premature ageing and high risk of cancer. Molecular and cellular mechanisms involved in these diseases are not well defined. Particularly, little is known concerni...

  3. Alteration of the digestive motility linked with radiation-induced inflammatory processes in rats; Alterations de la motricite digestive associees aux processus inflammatoires induits par les rayonnements ionisants chez le rat

    Energy Technology Data Exchange (ETDEWEB)

    Picard, C

    2000-12-01

    Exposure to ionizing radiation, whether accidental or for medical reasons, may lead to gastro-intestinal injury, characterized by nausea, vomiting, diarrhea and abdominal cramps. The aetiology of radiation-induced diarrhea remains to date unclear. In this study, we have investigated the acute effects of a 10 Gy abdominal irradiation on rat digestive functions. The objective of the first study was to evaluate the role of sensory afferent neurons, capsaicin-sensitive, on morphological changes and the inflammatory response following exposure. Three days after irradiation, we observed an inflammatory response characterized by neutrophils infiltration and mast cells de-granulation. No effect of capsaicin pre-treatment was seen on these parameters. However, neutrophils infiltration was increased as early as one day after irradiation in capsaicin-treated rats. No difference in severity of diarrhea was observed after denervation nor in morphological changes. These data demonstrate that abdominal irradiation results in diarrhea concomitant with an inflammatory response, and that sensory innervation does not play a major protective role. The objective of the rest of the work was in the first instance to characterize radiation-induced alterations of intestinal and colonic motility leading to diarrhea and secondly to evaluate the role of serotonin in such disorders. Perturbations in intestinal (MMC) and colonic (LSB) motor profiles were observed from the first day onwards. Migrating motor complexes (MMC) were completely disrupted at three days at the same time as the onset of diarrhea. In addition to inhibition of LSB, colonic fluid absorptive capacity was decreased and serotonin colonic tissue levels were increased three days after irradiation. Radiation-induced diarrhea was reduced by treatment with an antagonist of 5-HT{sub 3} receptors, granisetron, as were alterations of colonic motility and serotonin tissue levels. However, this treatment did not significantly ameliorate fluid absorption on three days. These two studies show that a 10 Gy abdominal irradiation markedly affects intestinal and colonic motility both of which contribute to the ensuing diarrhea, and a role for serotonin via 5-HT{sub 3} receptors. In conclusion, these results demonstrate functional modifications without marked alterations of intestinal and colonic morphology. These changes are concomitant with an inflammatory response which does not appear to involve afferent nerves. However, serotonin plays an important role in the inhibition of colonic motility and in consequence in the establishment of diarrhea. (author)

  4. Characterization of ionizing radiation effects in MOS structures by study of bipolar operation; Caracterisation des effets induits par irradiations ionisantes dans des structures MOS a partir de leur fonctionnement en regime bipolaire

    Energy Technology Data Exchange (ETDEWEB)

    Bakhtiar, H. [Univ. Teknologi Malaysia, Dept. of Physics, Johor (Malaysia); Picard, C.; Brisset, C. [CEA Saclay, Lab. d' Electronique et de Technologie de l' Informatique, LETI, 91 - Gif-sur-Yvette (France); Bakhtiar, H.; Hoffmann, A.; Charles, J.P. [Metz Univ., LICM-CLOES-Supelec, 57 (France)

    1999-07-01

    This work presents an original method to characterize radiation effects of micronic transistors. The characterization includes a study of the transistor substrate-drain junction and current gain variation of the bipolar transistor (drain-substrate-source as emitter-base-collector) for different gate voltages. (author000.

  5. Experimental analysis of recombination and neutralization of radiation-induced charges, using isochronal annealing; Mise en evidence experimentale, a l'aide de recuits isochrones, des mecanismes de recombinaison et de neutralisation de la charge induite par les radiations

    Energy Technology Data Exchange (ETDEWEB)

    Quittard, O.; Brisset, C.; Joffre, F. [CEA Saclay, Lab. d' Electronique et de Technologie de l' Informatique, LETI, 91 - Gif-sur-Yvette (France); Oudea, C. [Aerospatiale, Service YY/CT, 78 - Les Mureaux (France); Saigne, F.; Dusseau, L.; Fesquet, J.; Gasiot, J. [Montpellier-2 Univ., CEM2, 34 (France)

    1999-07-01

    The experimental analysis described in this paper made use of the isochronal principle to carry out qualitative and quantitative studies of both aspects of the RICN mechanism (radiation-induced charge neutralization) : recombination and compensation. (authors)

  6. Etude de nouveaux biomarqueurs de toxicité induite par des micropolluants (benzo(a)pyrène et phtalate de bis(2-ethylhexyle)) sur des modèles de placenta humain

    OpenAIRE

    Wakx, Anaïs

    2014-01-01

    Prenatal exposure to pollutants is commonly evaluated using placenta as a barrier between mother and fetus. Here, we consider placenta as a target organ for toxic agents. To achieve this, we selected a trophoblastic cell model, which is adapted to toxicological studies. In clinical studies, pregnancy pathologies are associated to changes in human placental lactogen (hPL) and human chorionic gonadotropin (hCG) secretions. Our in vitro work links exposure to micropollutants (mono(2-ethylhexyl)p...

  7. Characterisation in vivo of ways of induced deaths by p53, in the male germinal cells; Caracterisation in vivo des voies de mort induites par la p53, dans les cellules germinales males

    Energy Technology Data Exchange (ETDEWEB)

    Coureuil, M

    2006-10-15

    The male germinal cells constitute a heterogeneous cell population including pre-meiotic proliferating cells (spermatogonia) and meiotic cells and post meiotic cells in differentiation (spermatocytes and spermatids). We study the involvement in vivo of the p53 protein in the death of these cells with the help of two models, (1) a transgenic model of infertility, MTp53, in which the p53 is over expressed in the differentiated cells and induced their death, (2) the response of these cells to gamma irradiation, where only the spermatogonia die by apoptosis dependent of p53. We showed that the caspases (cysteine-aspartic proteases) are involved in the terminal differentiation of normal germinal cells. But in the MTp53 model, the p53 induces the death of differentiated cells via the activation of calpains and not of caspases. We studied the response of spermatogonia, to gamma irradiation by a transcriptomic approach, by DNA chips and semi-quantitative RT-PCR. we showed that the puma and dr5 genes are induced by the p53 after irradiation. more, the study of mice invalidated for trail ( the dr5 ligand) or for puma, allowed to demonstrate that the two effectors are essential to the activation of intrinsic and extrinsic ways of apoptosis. (N.C.)

  8. Muscular fixing of the H.M.D.P. {sup 99m}Tc induced by a statin, rosuvastatin or crestor: clinical case; Fixation musculaire du HMDP Tc99m induite par une statine, la rosuvastatine ou Crestor: cas clinique

    Energy Technology Data Exchange (ETDEWEB)

    Bourahla, K.; Hassler, S.; Schneegans, O.; Gyen, L.N. [CLCC Paul-Strauss, Service de medecine nucleaire, 67 - Strasbourg (France)

    2010-07-01

    Myositis induced by statins in treatment for hypercholesterolemia is a special clinical entity that may be encountered during an exploration by bone scintigraphy. We present the case of a muscle fixing observed in bone scan in a patient treated with rosuvastatin (Crestor). Muscular extra bone fixing of hydroxy-methane diphosphonate (H.M.D.P.) {sup 99m}T in patients referred for staging of prostate carcinoma, patients sometimes also treated for high cholesterol may be iatrogenic due to taking statins. A simple history may then allow its identification, although it remains asymptomatic. (N.C.)

  9. Study of the neutron background noise generated by muons in the Edelweiss-2 experiment; Etude du bruit de fond neutron induit par les muons dans l'experience EDELWEISS-2

    Energy Technology Data Exchange (ETDEWEB)

    Chabert, L

    2004-07-01

    This thesis contributes to the Edelweiss experiment whose aim is to detect interactions between neutralinos and target nuclei. Bolometers used in Edelweiss combine the detection of phonons with the detection of electric charges generated by the energy deposition. This double detection enables us to discard background signals due to electronic interactions and soon detection sensitivity of the experiment will be limited by the neutron background noise due to residual cosmic muons. This work is dedicated to a detailed study of muon inelastic interactions and the consequent production of neutrons. Simulations show that the expected neutron flux is so high that the direct detection of muons is required in order to link it to the neutron signal issued by the bolometer. Results from simulations show that plastic scintillators might be the main components of the muon detector.

  10. Localized corrosion of carbon steels due to sulfate-reducing bacteria. Development of a specific sensor; Corrosion localisee des aciers au carbone induite par des bacteries sulfato-reductrices. Developpement d'un capteur specifique

    Energy Technology Data Exchange (ETDEWEB)

    Monfort Moros, N.

    2001-11-01

    This work concerns the microbiologically influenced corrosion of carbon steels in saline anaerobic media (3% of NaCl) containing sulfato-reducing bacteria (Desulfovibrio gabonensis, DSM 10636). In these media, extreme localised corrosion occurs by pitting under the bio-film covering the metallic substrate. A sensor with concentric electrodes was designed to initiate the phenomenon of bio-corrosion, recreating the favourable conditions for growth of a corrosion pit, and then measuring the corrosion current maintained by bacterial activity. The pit initiation was achieved through either of two methods. The electrochemical conditioning involved driving the potential difference between inner and outer electrodes to values corresponding to a galvanic corrosion that can be maintained by the bacterial metabolism. The mechanical process involved removal of a portion of the bio-film by scratching, yielding galvanic potential differences equivalent to that found by the conditioning technique. This protocol was found to be applicable to a bio-corrosion study on industrial site for the monitoring of the metallic structures deterioration (patent EN 00/06114, May 2000). Thereafter, a fundamental application uses the bio-corrosion sensor for Electrochemical Impedance Spectroscopy (EIS), Electrochemical Noise Analysis (ENA) and current density cartography by the means of micro-electrodes. Thus, the EIS technique reveals the importance of the FeS corrosion products for initiation of bio-corrosion start on carbon steel. In addition, depending on the method used to create a pit, the ENA gives rise to supplementary processes (gaseous release) disturbing the bio-corrosion detection. The beginning of a bio-corrosion process on a clean surface surrounded with bio-film was confirmed by the current density cartography. These different results establish the sensor with concentric electrodes as an indispensable tool for bio-corrosion studies, both in the laboratory and on industrial sites. (author)

  11. Caractérisation de l'interaction entre la glycoprotéine d'enveloppe gp120 du VIH-1 et les héparanes sulfate : importance des changements conformationnels induits par la liaison à CD4

    OpenAIRE

    Crublet , Elodie

    2008-01-01

    During viral entry, HIV surface glycoprotein gp120 binds to CD4, thereby anchoring the virus to the host cell surface. This interaction induces conformational changes within gp120 that expose CD4-induced (CD4i) epitope, the binding site for coreceptors (usually a member of the chemokine receptor family). In addition, HIV binds to heparan sulphate (HS), an abundant cell surface polysaccharide, through several domains of gp120, including CD4i. Thus, it may be possible to inhibit HIV binding to ...

  12. État des connaissances et incertitudes sur le changement climatique induit par les activités humainesScientific basis and uncertainties of human induced climate change

    Science.gov (United States)

    Duplessy, Jean-Claude

    2001-12-01

    During the 20th century, the mean temperature of the air at the ground level has increased by 0.6±0.2 °C and the warmest air temperatures occurred after 1980. These were significantly warmer than those of the last millennium. Simultaneously, rain and drought, cold and heat wave frequencies have changed, mountain glaciers retreated and the sea-level increased by ˜10 cm. This warming was at least in part induced by human activities and will continue during the next decades. Its amplitude will depend on the rate of greenhouse gas and sulphate aerosols emissions, i.e. on energetic scenarios. Pending scientific uncertainties include cloud variations and interactions between the physical parts of the climate system and the biogeochemical cycles and the biosphere.

  13. Redox reactions induced by hydrogen in deep geological nuclear waste disposal; Transformations mineralogiques et geochimiques induites par la presence d'hydrogene dans un site de stockage de dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Truche, L.

    2009-10-15

    The aim of this study is to evaluate the abiotic hydrogen reactivity in deep geological nuclear waste storage. One crucial research interest concerns the role of H{sub 2} as a reducing agent for the aqueous/mineral oxidised species present in the site. Preliminary batch experiments carried out with Callovo-Oxfordian argillite, synthetic pore water and H{sub 2} gas lead to an important H{sub 2}S production, in only few hours at 250 C to few months at 90 C. In order to explore whether H{sub 2}S can originate from sulphate or pyrite (few percents of the argillite) reduction we performed dedicated experiments. Sulphate reduction experimented in di-phasic systems (water+gas) at 250-300 C and under 4 to 16 bar H{sub 2} partial pressure exhibits a high activation energy (131 kJ/mol) and requires H{sub 2}S initiation and low pH condition as already observed in other published TSR experiments. The corresponding half-life is 210,000 yr at 90 C (thermal peak of the site). On the contrary, pyrite reduction into pyrrhotite by H{sub 2} occurs in few days at temperature as low as 90 C at pH buffered by calcite. The rate of the reaction could be described by a diffusion-like rate law in the 90-180 C temperature interval. The obtained results suggest that pyrite reduction is a process controlled both by the H{sub 2} diffusion across the pyrrhotite pits increasing during reaction progress and the reductive dissolution of pyrite. These new kinetics data can be applied in computation modelling, to evaluate the degree and extent of gas pressure buildup by taking into account the H{sub 2} reactive geochemistry. (author)

  14. Oxydation des protéines et des lipides dans les fromages induite par la lumière : incidence de la teneur en matière grasse et des conditions d'emballage

    OpenAIRE

    Kastrup Dalsgaard, Trine; Sørensen, John; Bakman, Mette; Vognsen, Lene; Nebel, Caroline; Albrechtsen, Rita; Nielsen, Jacob H.

    2010-01-01

    International audience; Photo-oxidation of cheese products has become an issue due to the fact that packaging of cheeses in transparent materials is very frequently used. The present study aimed to investigate the effect of fat content and availability of oxygen on light-induced oxidation in cheese, as we expected that the fat content would affect the oxidation pathways. Two different model cheeses with 5.4% and 18% fat were packed in air and in vacuum, respectively. The contents of protein (...

  15. MUST, a set of strip detectors for studying radioactive beams induced reactions; MUST, un ensemble de detecteurs a pistes pour l`etude des reactions induites par faisceaux radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Blumenfeld, Y.; Barbier, A.; Beaumel, D.; Charlet, D.; Clavelin, J.F.; Douet, R.; Engrand, M.; Lebon, S.; Lelong, P.; Lesage, A.; Leven, V.; Lhenry, I.; Marechal, F.; Petizon, L.; Pouthas, J.; Richard, A.; Rougier, D.; Soulet, C.; Suomijaervi, T.; Volkov, P.; Voltolini, G. [Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire; Auger, F.; Ottini, S.; Alamanos, N. [CEA Centre d`Etudes de Saclay, 91 - Gif-sur-Yvette (France). Dept. d`Astrophysique, de la Physique des Particules, de la Physique Nucleaire et de l`Instrumentation Associee; Sauvestre, J.E.; Bonnereau, B.; Champion, L.; Delbourgo-Salvador, P.; Ethvignot, T.; Szmigiel, M. [CEA Centre d`Etudes de Bruyeres-le-Chatel, 91 (France)

    1996-12-31

    This report states the specificity of light particles elastic scattering, and the need of detecting recoil protons to improve angular resolution. Then the development of a specific MUST strip detector is detailed: 60 strips detectors with Si O sub 2 dielectric, that yield 500 ps time resolution, and Si (Li) detectors following next. A versatile data acquisition system has been developed too, with CAMAC interface to suit to any experimental plant. (D.L.). 27 refs.

  16. Incidence de l’action chaleur sur les symptômes induits par la maladie du « Green crinkle » sur le cultivar de pommier Golden Delicious (M. x domestica Borkh.)

    OpenAIRE

    Lemoine, Jacques

    1987-01-01

    L’intensité et la fréquence des symptômes de la maladie du « Green crinkle » sur les fruits de la variété de pommier ’Golden Delicious’ varient d’une année à l’autre. Les symptômes sont soit de faibles déformations des fruits (« Green crinkle ») soit de fortes déformations accompagnées de nécroses (« Star crack »). Une étude conduite pendant 7 années en conditions naturelles a mis en évidence le rôle de l’action chaleur au cours des deux premiers mois de la vie du fruit, sur la sévérité d...

  17. Sub-micron indent induced plastic deformation in copper and irradiated steel; Deformation plastique induite par l'essai d'indentation submicronique, dans le cuivre et l'acier 316L irradie

    Energy Technology Data Exchange (ETDEWEB)

    Robertson, Ch

    1999-07-01

    In this work we aim to study the indent induced plastic deformation. For this purpose, we have developed a new approach, whereby the indentation curves provides the mechanical behaviour, while the deformation mechanisms are observed thanks to Transmission Electron Microscopy (TEM). In order to better understand how an indent induced dislocation microstructure forms, numerical modeling of the indentation process at the scale of discrete dislocations has been worked out as well. Validation of this modeling has been performed through direct comparison of the computed microstructures with TEM micrographs of actual indents in pure Cu (001]. Irradiation induced modifications of mechanical behaviour of ion irradiated 316L have been investigated, thanks to the mentioned approach. An important hardening effect was reported from indentation data (about 50%), on helium irradiated 316L steel. TEM observations of the damage zone clearly show that this behaviour is associated with the presence of He bubbles. TEM observations of the indent induced plastic zone also showed that the extent of the plastic zone is strongly correlated with hardness, that is to say: harder materials gets a smaller plastic zone. These results thus clearly established that the selected procedure can reveal any irradiation induced hardening in sub-micron thick ion irradiated layers. The behaviour of krypton irradiated 316L steel is somewhat more puzzling. In one hand indeed, a strong correlation between the defect cluster size and densities on the irradiation temperature is observed in the 350 deg. C - 600 deg. C range, thanks to TEM observations of the damage zone. On the other hand, irradiation induced hardening reported from indentation data is relatively small (about 10%) and shows no dependence upon the irradiation temperature (within the mentioned range). In addition, it has been shown that the reported hardening vanishes following appropriate post-irradiation annealing, although most of the TEM identified clusters seems not to be affected by such thermal treatment. In order to rationalize these results, we suggest that krypton irradiation induced hardening is produced by defect clusters more unstable and smaller than those mentioned. (author)

  18. Conception et développement d'outils immunologiques pour suivre et caractériser les réponses immunitaires induites par les vaccins contre l'allergie

    OpenAIRE

    Wambre , Eric

    2008-01-01

    Type I allergy either results from a pathological inappropriate Th2 immune response or from the defective induction of immune tolerance to otherwise harmless antigen : the allergen. Recent advances have underlined the major role played by allergen-specific CD4+ T cells in the control of allergic response. However, immunological mechanisms involved remain to be better documented and could provide important information regarding peripheral tolerance induction observed in healthy individuals. Ex...

  19. Recherche documentaire par titrage automatique

    OpenAIRE

    Lopez , Cédric; Prince , Violaine; Roche , Mathieu

    2011-01-01

    Nous proposons dans cet article un système facilitant la recherche d'information dans un ensemble de documents textuels, basé sur le titrage (et sous-titrage) automatique. Ce dernier peut se révéler crucial, par exemple, dans le cadre de la problématique de l'accessibilité des pages web (norme W3C). Notre processus de titrage automatique consiste à extraire des syntagmes nominaux pertinents dans les textes, pouvant constituer des titres ou sous-titres candidats. Une approche originale combina...

  20. Tratamiento cognitivo-conductual protocolizado en grupo de las enfermedades inflamatorias intestinales Protocolized cognitive-behavioural group therapy for inflammatory bowel disease

    Directory of Open Access Journals (Sweden)

    M. A. Díaz Sibaja

    2007-10-01

    Full Text Available Introducción: los pacientes con enfermedades inflamatorias intestinales presentan una mayor tasa de alteraciones psicopatológicas que la población normal, predominantemente ansiedad y depresión. Objetivo: el principal objetivo de este estudio fue diseñar, poner en práctica y validar un programa de tratamiento psicológico protocolizado, basado en el modelo de competencias y con una metodología psicoeducativa, en el que se incluyeron los siguientes módulos de intervención: información de la enfermedad, modelo de afrontamiento, solución de problemas, técnicas de relajación, entrenamiento en habilidades sociales, técnicas de distracción y técnicas de reestructuración cognitiva. Todas estás técnicas fueron adaptadas a la problemática característica de la enfermedad inflamatoria intestinal. Método: la muestra estuvo constituida por 57 pacientes diagnosticados de enfermedad inflamatoria intestinal de la Asociación de Enfermos de Crohn y Colitis Ulcerosa de España. La muestra se distribuyó aleatoriamente en dos grupos experimentales, 33 formaron parte del programa de tratamiento en grupo y 24 fueron asignados al grupo control en lista de espera. Las variables emocionales medidas fueron: ansiedad y depresión. Resultados: los resultados reflejaron una mejoría clínica y estadísticamente significativa en las variables de ansiedad (p Introduction: patients affected by inflammatory bowel disease have a high rate of psychiatric disorders such as depression and anxiety. Objective: the main goal of this study was to design, to put into practice, and to validate a protocolized psychological treatment program based on the coping model, and a psycho-educational methodology in which the following intervention modules were included- illness information, coping model, problem solving techniques, relaxation, social skill training, distraction, and cognitive restructuring techniques. All these techniques were adapted to the characteristic

  1. SECHAGE DE PRODUITS GRANULAIRES PAR DESHYDRATATION PAR DETENTES SUCCESSIVES (DDS)

    OpenAIRE

    Abdulla , Galal; Mellouk , Hamid; Belghit , Abdelhamid; Allaf , Karim

    2009-01-01

    International audience; Dans cette étude, nous avons évalué les performances d'un nouveau procédé de séchage dans le cas du liège en granulés. Ce procédé (La déshydratation par détentes successives : DDS) consiste à soumettre le matériau liège dans une chambre hermétique aux variations cycliques de la pression. Chaque cycle est composé d'une compression et d'une décompression. La phase de compression est réalisée en injectant de l'air comprimé à température ambiante provenant d'un compresseur...

  2. Micro-ion beam analysis of physico-chemical reactions in vitro induced by nano-structured sol-gel derived bioactive glasses; Caracterisation par micro-faisceau d'ions des reactions physico-chimiques induites in vitro par des verres bioactifs nanostructures elabores par la methode sol-gel

    Energy Technology Data Exchange (ETDEWEB)

    Lao, J

    2007-07-15

    The study of bioactive glasses is a multi-field area of research aiming at a major goal: the development of new generation biomaterials that would be able to bond with host tissues through the formation of a strong interfacial bond, together with helping the body heal itself through the stimulation of specific cellular responses. Thus clinical applications of bioactive glasses mainly concern dental surgery and orthopedics, for filling osseous defects. For this purpose, we have elaborated bioactive glasses in the binary SiO{sub 2}-CaO system, ternary SiO{sub 2}-CaO-P{sub 2}O{sub 5} system, and for the first time, to our knowledge, strontium-doped SiO{sub 2}-CaO-SrO and SiO{sub 2}-CaO-P{sub 2}O{sub 5}-SrO glasses. The materials were elaborated using the sol-gel process, which allowed the synthesis of nano-porous materials with great purity and homogeneity. The bio-activity of the glasses was clearly demonstrated in vitro: in contact with biological fluids, the whole lot of mate-rials were able to induce the formation of a Ca-P-Mg layer a few microns thick at their surface. Our work is characterized by the use of PIXE-RBS nuclear microprobes to study the bioactive glass/biological fluids interface. Thanks to these methods we obtained chemical maps that made possible the analysis of major and trace elements concentrations at the interface. Moreover, quantitative information regarding the local reactivity of glasses were acquired. These data are important to evaluate the kinetics and amplitude of the physico-chemical reactions involved in the bio-activity process. Thus, we highlighted that the binary glass is the highest reactive regarding the dissolution of the glassy matrix as well as the first appearance of the Ca-P rich layer. However the Ca/P atomic ratio calculated at the glass/biological fluids interface decreases slowly, indicating that the Ca-P-Mg layer encounters difficulties to be changed into a more stable apatitic phase. For the P-containing glasses, the de-alkalinization of the matrix and the formation of the calcium phosphate layer are delayed. However, calculation of the interfacial Ca/P ratios along with supersaturation studies of the biological medium demonstrate that the Ca-P-Mg layer is quickly changed into an apatitic phase. Concerning the Sr-doped glasses, we highlighted that the dissolution of the material decreased and that the Ca-P-Mg layer was formed on a reduced depth. Nevertheless, according to the rapid decrease of the Ca/P ratio, there is evidence that the layer is more quickly changed into apatite, We also demonstrated that traces of Sr are both present at the glass/biological fluids interface and diffused in the biological medium. Knowing the positive effects of Sr on the cellular activity and on the bone modelling process, it might result in an improved bio-activity for the Sr-doped glasses in contact with a living system. (author)

  3. La preuve par le nombre

    Directory of Open Access Journals (Sweden)

    Hélène Verdier

    2012-04-01

    Full Text Available S’il en était besoin, la question des usages et de la finalité des résultats de l’inventaire général pourrait être abordée par le nombre : nombre d’œuvres répertoriées, de communes inventoriées, de clichés photographiques réalisés, de dossiers, de consultations des notices dans les bases de données… Les additions aujourd’hui sont éloquentes, mais elles laissent dans l’ombre le rôle de l’inventaire qui, en mettant en œuvre une démarche systématique de connaissance, participe à l’ identificatio...

  4. Par Pond vegetation status Summer 1995 -- Summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1996-01-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the newly emergent, shoreline aquatic plant communities of Par Pond began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level. These surveys continued in July, September, and late October, 1995. Communities similar to the pre-drawdown, Par Pond aquatic plant communities are becoming re-established. Emergent beds of maidencane, lotus, waterlily, and watershield are extensive and well developed. Cattail occurrence continued to increase during the summer, but large beds common to Par Pond prior to the drawdown have not formed. Estimates from SPOT HRV, remote sensing satellite data indicated that as much as 120 hectares of emergent wetlands vegetation may have been present along the Par Pond shoreline by early October, 1995. To track the continued development of macrophytes in Par Pond, future surveys throughout 1996 and 1997, along with the continued evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  5. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis...

  6. ¡París!

    Directory of Open Access Journals (Sweden)

    Beatriz Caballero

    2003-01-01

    Full Text Available El día no le alcanzaba para caminarlo. Conocía cada puente, cada calle,plaza, museo, rincón, iglesia, café, y la mesa con el mejor ángulo para mirar siempre una iglesia, ojalá Saint-Germain-des-Pres, o Notre-Dame. Siempre contaba la impresión que le había causado a Bolívar ver allí cuando el papa coronó a Napoleón. Él se iba para la oficina todos los días, Luis a un taller a pintar, Antonio a estudiar ciencias políticas, yo al colegio y mamá hacía las cosas prácticas. Aprendíamos francés todos al tiempo y por la noche nos contábamos lo nuevo que cada uno había aprendido. Mamá después, cuando ya se quería volver, decía que París nos había maleado a todos. Estaba en pleno furor el cine francés de la "nueva ola", pero ella sólo me llevaba a ver películas de vaqueros pues no se fiaba de la clasificación de los periódicos.

  7. étude par AFM dynamique.

    African Journals Online (AJOL)

    user

    Rwanda Journal Volume 20, Series C, 2011 : Mathematical Sciences, Engineering and Technology. 53. - un tube piézoélectrique assurant le déplacement relatif, dans les trois directions x, y, z de l'espace, de la pointe par rapport à l'échantillon. L'acquisition des données s'effectue par asservissement de la position de la.

  8. Adiestramiento en el diagnóstico de las parasitosis intestinales en la red de laboratorios de Cuba Training for diagnosis of intestinal parasites in the national laboratory system in Cuba

    Directory of Open Access Journals (Sweden)

    Fidel Angel Núñez

    2001-06-01

    Full Text Available En 1997, se desarrolló un proyecto nacional de adiestramiento integral para el diagnóstico de las parasitosis intestinales, el que incluyó 4 cursos; uno com carácter nacional, y otros 3 en las provincias centrales, orientales y occidentales. Al comparar los errores diagnósticos, vimos que Cryptosporidium parvum, Cyclospora cayetanensis y los leucocitos mostraron un porcentaje significativamente menor de fallas después del curso que al comienzo (p 0,05. Por otra parte, al comparar las medias de las puntuaciones antes y después de los cursos, se encontró un aumento significativo en el curso de las provincias centrales (pA national training project in the diagnosis of intestinal parasites was conducted in 1997. An initial national course was followed respectively by courses in the Central, Eastern, and Western Provinces. Our results showed that Cryptosporidium parvum, Cyclospora cayetanensis, and leukocytes showed a significantly lower percentage of errors after the training than before (p 0.05. Furthermore, when comparing scores before and after training, a significant increase in median scores appeared in the Central Provinces (p < 0.05, Western Provinces (p < 0.01, and in the entire series (p < 0.01. The results showed the effectiveness of this intervention; these periodic mandatory training courses should be developed together with national programs for quality assessment in Parasitology.

  9. Comparación de varias técnicas coproparasitológicas para el diagnóstico de geohelmintiasis intestinales Comparison of several coproparasitological techniques for diagnosis of soil-transmitted helminthiasis

    Directory of Open Access Journals (Sweden)

    Fidel Ángel Núñez-Fernández

    1991-10-01

    Full Text Available Se procesan "a ciegas" 511 muestras de heces por las técnicas de Kato-Katz, Willis, Ritchie y directo. Al comparar los resultados obtenidos en el diagnóstico de Trichuris trichiura, Necator americanus y Ascaris lumbricoides, vimos que la de Kato-Katz fué más sensible, revelando el mayor número de casos, siguiéndole en orden sucesivo, el Willis, el Ritchie, y el examen directo. Si se tiene en cuenta que el método de Kato-Katz es además cuantitativo, podemos recomendar-lo como técnica de elección para el diagnóstico de las geohelmintiasis intestinales.Five hundred and eleven samples of feces were examined by several coproparasilological techniques: Kalo-Katz, Willis, Ritchie and direct wet mount. It was found that Kato-Katz was the most reliable technique for the diagnosis of Trichuris trichiura, Necator americanus, and Ascaris lumbricoides, demonstrating the largest number of cases. Willis, Ritchie and direct wet mount were effective in that order. Taking into account that Kato-Katz is a quantitative method, it should be recommended in the diagnosis of soil-transmitted helminthiasis.

  10. C9.A/14 steelwork joints de poutres par plaque frontale : assemblages par gousset

    CERN Document Server

    2015-01-01

    Les Tables de résistances ultimes des assemblages boulonnés par plaque frontale et par gousset, complétées par une description des modèles de calcul et des exemples d’application, ont pour but de faciliter la tâche de l'ingénieur et du constructeur. Cette première partie C9.A/14 contient les chapitres suivants: - Joints de poutres par plaque frontale en acier S235 et S355 - Assemblages par gousset en acier S235 et S355 Les Tables contiennent des données relatives à la géométrie ainsi que les valeurs de calcul correspondantes des résistances ultimes des assemblages ; elles remplacent le chapitre « Assemblages par plaques frontales et boulons HR » des anciennes Tables C9.1 de 1983 / 2002. Le calcul de ces assemblages par plaque frontale est basé sur les hypothèses du modèle de la méthode des composants décrite dans la norme SN EN 1993-1-8. Les vérifications sont effectuées selon la norme SIA 263:2013. Les assemblages par gousset remplacent les assemblages par double cornière, (telle...

  11. Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis

    NARCIS (Netherlands)

    Lin, Cong; von der Thüsen, Jan; Daalhuisen, Joost; ten Brink, Marieke; Crestani, Bruno; van der Poll, Tom; Borensztajn, Keren; Spek, C. Arnold

    2015-01-01

    Idiopathic pulmonary fibrosis is the most devastating diffuse fibrosing lung disease of unknown aetiology. Compelling evidence suggests that both protease-activated receptor (PAR)-1 and PAR-2 participate in the development of pulmonary fibrosis. Previous studies have shown that bleomycin-induced

  12. Parálisis criptogénica del III par craneal

    Directory of Open Access Journals (Sweden)

    Albia Josefina Pozo Alonso

    Full Text Available La parálisis aislada del tercer par craneal no es frecuente en los niños. Entre las causas que la originan se encuentran las congénitas, traumáticas, infecciosas, tumorales, vasculares, tóxicas y desmielinizantes. Se presenta un paciente de 3 años de edad con el diagnóstico de una oftalmoplejía aguda dolorosa del tercer par craneal, cuya etiología no se pudo demostrar. El cuadro clínico desapareció de forma espontánea y no ha presentado recurrencias después de 3 años de seguimiento. Se concluye que ante un paciente con parálisis del tercer par craneal es necesario realizar una exhaustiva evaluación con el propósito de precisar las diversas causas que la provocan.

  13. Le stockage thermique par chaleur latente

    OpenAIRE

    Martin, F.; Nicolas, Jacques

    1988-01-01

    L'article présente le principe du stockage d'énergie par transformation de phase ainsi que les matériaux employés (composés organiques, sels hydratés et matériaux à transformation solide-solide) et les différents types d'échangeurs. Peer reviewed

  14. Coinfection pulmonaire par pneumocystis jirovecii et pseudomonas ...

    African Journals Online (AJOL)

    Sous traitement, l'évolution a été favorable. Les coinfections morbides sont relativement fréquentes chez les patients vivant avec le VIH. Devant une symptomatologie respiratoire du sujet vivant avec le VIH, il faut savoir rechercher en plus du Bacille de Koch, Pneumocystis jirovecii et Pseudomonas aeruginosa par un ...

  15. PAR-TERRA directs homologous sex chromosome pairing.

    Science.gov (United States)

    Chu, Hsueh-Ping; Froberg, John E; Kesner, Barry; Oh, Hyun Jung; Ji, Fei; Sadreyev, Ruslan; Pinter, Stefan F; Lee, Jeannie T

    2017-08-01

    In mammals, homologous chromosomes rarely pair outside meiosis. One exception is the X chromosome, which transiently pairs during X-chromosome inactivation (XCI). How two chromosomes find each other in 3D space is not known. Here, we reveal a required interaction between the X-inactivation center (Xic) and the telomere in mouse embryonic stem (ES) cells. The subtelomeric, pseudoautosomal regions (PARs) of the two sex chromosomes (X and Y) also undergo pairing in both female and male cells. PARs transcribe a class of telomeric RNA, dubbed PAR-TERRA, which accounts for a vast majority of all TERRA transcripts. PAR-TERRA binds throughout the genome, including to the PAR and Xic. During X-chromosome pairing, PAR-TERRA anchors the Xic to the PAR, creating a 'tetrad' of pairwise homologous interactions (Xic-Xic, PAR-PAR, and Xic-PAR). Xic pairing occurs within the tetrad. Depleting PAR-TERRA abrogates pairing and blocks initiation of XCI, whereas autosomal PAR-TERRA induces ectopic pairing. We propose a 'constrained diffusion model' in which PAR-TERRA creates an interaction hub to guide Xic homology searching during XCI.

  16. Nuclear structure of weakly bound radioactive nuclei through elastic and and inelastic scattering on proton. Impacts of the couplings induced by these exotic nuclei on direct reactions; Structure de noyaux radioactifs faiblement lies par diffusions elastiques et inelastiques sur proton. Effets des couplages induits par ces noyaux exotiques sur les reactions directes

    Energy Technology Data Exchange (ETDEWEB)

    Lapoux, V

    2005-09-15

    Information on the structure, spectroscopy and target interaction potentials of exotic nuclei can be inferred by interpreting measured data from direct reactions on proton such as elastic or inelastic scattering of proton (p,p') or one-nucleon transfer reaction (p,d). A series of experimental results has been obtained at the GANIL facilities on the setting composed of the MUST telescope array used for the detection of light charged-particles and of CATS beam detectors. This setting aims at measuring reactions on light proton or deuteron targets through reverse kinematics. Particularly, results on C{sup 10}, C{sup 11} and on direct reactions with the He{sup 8} beam of Spiral are presented. The first chapter is dedicated to the description of the most important theories concerning the nucleus. The experimental tools used to probe the nucleus are reported in the second chapter. The third and fourth chapters present the framework that has allowed us to analyse results from (p,p') and (p,d) reactions on weakly bound exotic nuclei. The last chapter is dedicated to the description of future experimental programs. (A.C.)

  17. Properties of point defects either native or induced by irradiation in the 3C and 6H polytypes of silicon carbide determined by positron annihilation and EPR; Proprietes des defauts ponctuels natifs et induits par irradiation dans les polytypes 3C et 6H du carbure de silicium determinees par annihilation de positons et RPE

    Energy Technology Data Exchange (ETDEWEB)

    Kerbiriou, X

    2006-02-15

    Potential applications of silicon carbide (SiC) in micro-electronics have justified many studies on point defects, which play an important role in the electrical compensation. Moreover, this material has many assets to take part in the fissile materials confining in the gas cooled reactors of the future (4. generation). In this thesis, we have used Electronic Paramagnetic Resonance and Positron Annihilation Spectroscopy to study the properties of point defects (nature, size, charge state, migration and agglomeration during annealing), either native or induced by irradiation with various particles (H{sup +}, e{sup -}, carbon ions), in the 3C and 6H polytypes of SiC. The positron annihilation study of native defects in 6H-SiC has shown the presence of a strong concentration of non-vacancy traps of acceptor type, which are not present in the 3C-SiC crystals. The nature of the defects detected after irradiation with low energy electrons (190 keV) depends on the polytype. Indeed, while silicon Frenkel pairs and carbon mono-vacancies are detected in the 6H crystals, only carbon mono-vacancies are detected in the 3C crystals. We propose that these differences concerning the populations of detected point defects result from different values of the silicon displacement threshold energy for the two polytypes (approximately 20 eV for 6H and 25 V for 3C). In addition, the irradiations with 12 MeV protons and 132 MeV carbon ions have created silicon mono-vacancies as well as VSi-VC di-vacancies. Neither the particle (protons or ions carbon), nor the polytype (3C or 6H) influence the nature of the generated defects. Finally the study of the annealing of 6H-SiC monocrystals irradiated with 12 MeV protons have revealed several successive processes. The most original result is the agglomeration of the silicon mono-vacancies with the VSi-VC di-vacancies which leads to the formation of VSi-VC-VSi tri-vacancies. (author)

  18. Analysis methods of neutrons induced resonances in the transmission experiments by time-of-flight and automation of these methods on IBM 7094 II computer; Methode d'analyse des resonances induites par les neutrons dans les experiences de transmission par temps-de-vol et automatisation de ces methodes sur ordinateur IBM-7094 II

    Energy Technology Data Exchange (ETDEWEB)

    Corge, C

    1967-07-01

    The neutron induced resonances analysis aims to determine the neutrons characteristics, leading to the excitation energies, de-excitation probabilities by gamma radiation emission, by neutron emission or by fission, their spin, their parity... This document describes the methods developed, or adapted, the calculation schemes and the algorithms implemented to realize such analysis on a computer, from data obtained during time-of-flight experiments on the linear accelerator of Saclay. (A.L.B.)

  19. Régulation de la colite induite par DSS et de la carcinogenèse du côlon associée à l'inflammation par les cils primaires des cellules mésenchymateuses du côlon

    OpenAIRE

    Tang, Ruizhi

    2017-01-01

    Glycylation, a posttranslational modification of microtubules, is crucial in the maintenance of PC. Our group previously identified an unexpected role of the tubulin glycylase TTLL3 in the regulation of colon homeostasis and tumorigenesis. Specifically, a decreased number of primary cilia (PC) was observed in mice deficient for the glycylase TTLL3, which is the only glycyclase expressed in the colon. TTLL3-/- mice display no obvious abnormalities in the steady state. However, when exposed to ...

  20. Centromere pairing by a plasmid-encoded type I ParB protein

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Löwe, Jan; Gerdes, Kenn

    2007-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes two trans-acting proteins, ParA and ParB, and two cis-acting sites, parC1 and parC2, to which ParB binds cooperatively. ParA is related to MinD and oscillates in helical structures and thereby positions ParB/parC-carrying plasmids regularly...

  1. Pars plana Baerveldt tube insertion with pars plana vitrectomy for refractory glaucoma

    Directory of Open Access Journals (Sweden)

    Anton M Kolomeyer

    2012-01-01

    Conclusions: Pars plana Baerveldt tube implantation with PPV can preserve vision, reduce IOP, and decrease the number of glaucoma medications necessary to achieve target IOP in patients with recalcitrant glaucoma.

  2. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — ABSTRACT: Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign...

  3. Copenhagen uPAR prostate cancer (CuPCa) database

    DEFF Research Database (Denmark)

    Lippert, Solvej; Berg, Kasper D; Høyer-Hansen, Gunilla

    2016-01-01

    AIM: Urokinase plasminogen activator receptor (uPAR) plays a central role during cancer invasion by facilitating pericellular proteolysis. We initiated the prospective 'Copenhagen uPAR Prostate Cancer' study to investigate the significance of uPAR levels in prostate cancer (PCa) patients. METHODS......: Plasma samples and clinical data from patients with newly diagnosed PCa have been collected prospectively. The uPAR forms have been measured in plasma using time-resolved fluorescence immunoassays. RESULTS: The level of intact uPAR(I-III) did not differ. Plasma uPAR(I-III) + uPAR(II-III) levels and u......PAR(I) levels were significantly higher in hormone-naive and castrate-resistant patients compared with patients with localized disease (both: p PCa....

  4. SAFARI 2000 PAR Measurements, Kalahari Transect, Botswana, Wet Season 2000

    Data.gov (United States)

    National Aeronautics and Space Administration — Ceptometer data from a Decagon AccuPAR (Model PAR-80) were collected at four sites in Botswana during the SAFARI 2000 Kalahari Transect Wet Season Campaign (March,...

  5. The inflammatory marker suPAR after cardiac arrest

    DEFF Research Database (Denmark)

    Rundgren, Malin; Lyngbaek, Stig; Fisker, Helle

    2015-01-01

    . This pilot study aimed at investigating suPAR levels in relation to outcome after CA and mild induced hypothermia. METHODS: suPAR levels were measured at 6, 36, and 72 hours in patients treated with hypothermia after CA. suPAR levels were analyzed in relation to survival after 6 months. Receiver operating...

  6. Molecular Mechanisms of Par-4-Induced Apoptosis in Prostate Cancer

    National Research Council Canada - National Science Library

    Ladias, John A

    2007-01-01

    .... Phosphorylation of Par-4 by Akt1 results in inhibition of apoptosis. To obtain insights into the mechanisms of Par-4 selective killing of prostate cancer cells, we expressed the human Par-4 SAC domain in bacteria and purified it to homogeneity...

  7. Macrophage Migration Inhibitory Factor Mediates PAR-Induced Bladder Pain.

    Directory of Open Access Journals (Sweden)

    Dimitrios E Kouzoukas

    Full Text Available Macrophage migration inhibitory factor (MIF, a pro-inflammatory cytokine, is constitutively expressed in urothelial cells that also express protease-activated receptors (PAR. Urothelial PAR1 receptors were shown to mediate bladder inflammation. We showed that PAR1 and PAR4 activator, thrombin, also mediates urothelial MIF release. We hypothesized that stimulation of urothelial PAR1 or PAR4 receptors elicits release of urothelial MIF that acts on MIF receptors in the urothelium to mediate bladder inflammation and pain. Thus, we examined the effect of activation of specific bladder PAR receptors on MIF release, bladder pain, micturition and histological changes.MIF release was measured in vitro after exposing immortalized human urothelial cells (UROtsa to PAR1 or PAR4 activating peptides (AP. Female C57BL/6 mice received intravesical PAR1- or PAR4-AP for one hour to determine: 1 bladder MIF release in vivo within one hour; 2 abdominal hypersensitivity (allodynia to von Frey filament stimulation 24 hours after treatment; 3 micturition parameters 24 hours after treatment; 4 histological changes in the bladder as a result of treatment; 5 changes in expression of bladder MIF and MIF receptors using real-time RT-PCR; 6 changes in urothelial MIF and MIF receptor, CXCR4, protein levels using quantitative immunofluorescence; 7 effect of MIF or CXCR4 antagonism.PAR1- or PAR4-AP triggered MIF release from both human urothelial cells in vitro and mouse urothelium in vivo. Twenty-four hours after intravesical PAR1- or PAR4-AP, we observed abdominal hypersensitivity in mice without changes in micturition or bladder histology. PAR4-AP was more effective and also increased expression of bladder MIF and urothelium MIF receptor, CXCR4. Bladder CXCR4 localized to the urothelium. Antagonizing MIF with ISO-1 eliminated PAR4- and reduced PAR1-induced hypersensitivity, while antagonizing CXCR4 with AMD3100 only partially prevented PAR4-induced hypersensitivity

  8. Deltagerinvolveret organisationsudvikling med PAR som metode

    DEFF Research Database (Denmark)

    Sparre, Mogens

    2017-01-01

    about the organization in an management group with a Participatory Action Research (PAR) case study? The article deals with a Phenomenological case study, where the researcher, with a PAR approach method, creates a research design with the purpose to influence the participant’s “Subjective perception......When a leader wants to initiate or influence some necessary changes in the organization, he must be aware of the fact that the subjects that form the organization create their own meaning about actions the manager wants implemented. This article confronts the assumption that people are by nature...... resistant to change. The quite widespread narrative of resistance to change, is believed to originate from the many top-down driven change projects implemented by the top management or/and external consultants. Is it possible to create a desired change in the form of the inter-subjective perception building...

  9. Les Brulures Chimiques Par Le Laurier Rose

    OpenAIRE

    Bakkali, H.; Ababou, M.; Nassim Sabah, T.; Moussaoui, A.; Ennouhi, A.; Fouadi, F.Z.; Siah, S.; Ihrai, H.

    2010-01-01

    Le laurier rose ou Nerium oleander est un arbuste qui pousse naturellement dans les régions méditerranéennes. Au Maroc on le trouve dans les lieux humides. Il est réputé par ses risques de toxicité systémique en cas d'empoisonnement à cause de la présence de deux alcaloïdes, surtout l'oléandrine. La littérature illustre des cas d'utilisation locale des feuilles de cette plante contre la gale, les hémorroïdes et les furoncles. Nous rapportons deux cas de brûlures chimiques par le laurier rose ...

  10. [Ambroise Paré in French literature].

    Science.gov (United States)

    Dumaitre, P

    1995-01-01

    The 16th century by its passionate side has been the favourite one of authors of historical novels in which among the heroes of "cloak and dagger stories" appears sometime Ambroise Paré. Alexandre Dumas (the father) has shown him at the court of Charles IX in La Reine Margot (1845) where he does not however play a great role. On the contrary, Balzac in Le Martyr calviniste (1842) has given him a capital part close to the dying François II, whom he intended to trepanize but had to give up this idea as a consequence of the opposition of the queen-mother Catherine de Médicis. In the present century, Robert Merle in Paris ma bonne ville (Fortune de France, 3, 1980) shows Paré at the time of the Saint Barthélemy.

  11. Par Pond refill water quality sampling

    Energy Technology Data Exchange (ETDEWEB)

    Koch, J.W. II; Martin, F.D.; Westbury, H.M.

    1996-08-01

    This study was designed to document anoxia and its cause in the event that the anoxia caused a fish kill. However, no fish kill was observed during this study, and dissolved oxygen and nutrient concentrations generally remained within the range expected for southeastern reservoirs. Par Pond water quality monitoring will continue during the second summer after refill as the aquatic macrophytes become reestablished and nutrients in the sediments are released to the water column.

  12. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  13. PAR1 antagonists inhibit thrombin-induced platelet activation whilst leaving the PAR4-mediated response intact.

    Science.gov (United States)

    Judge, Heather M; Jennings, Lisa K; Moliterno, David J; Hord, Edward; Ecob, Rosemary; Tricoci, Pierluigi; Rorick, Tyrus; Kotha, Jayaprakash; Storey, Robert F

    2015-01-01

    Thrombin-induced platelet activation is initiated by PAR1 and PAR4 receptors. Vorapaxar, a PAR1 antagonist, has been assessed in patients with acute coronary syndromes (ACS) and stable atherosclerotic disease in addition to standard-of-care treatment. In clinical trials, vorapaxar has been observed to reduce the frequency of ischaemic events in some subgroups though in others has increased the frequency of bleeding events. Among patients undergoing CABG surgery, which is associated with excess thrombin generation, bleeding was not increased. The aim of these studies was to investigate the effects of selective PAR1 antagonism on thrombin-induced platelet activation in patients receiving vorapaxar or placebo in the TRACER trial and to explore the roles of PAR1 and PAR4 in thrombin-induced platelet activation in healthy volunteers. ACS patients receiving vorapaxar or placebo in the TRACER trial were studied at baseline and 4 hours, 1 and 4 months during drug administration. Thrombin-induced calcium mobilisation in platelet-rich plasma was assessed by flow cytometry. In vitro studies were performed in healthy volunteers using the PAR1 antagonist SCH79797 or PAR4 receptor desensitisation. Vorapaxar treatment significantly inhibited thrombin-induced calcium mobilisation, leaving a residual, delayed response. These findings were consistent with calcium mobilisation mediated via the PAR4 receptor and were reproduced in vitro using SCH79797. PAR4 receptor desensitization, in combination with SCH79797, completely inhibited thrombin-induced calcium mobilisation confirming that the residual calcium mobilisation was mediated via PAR4. In conclusion vorapaxar selectively antagonises the PAR1-mediated component of thrombin-induced platelet activation, leaving the PAR4-mediated response intact, which may explain why vorapaxar is well tolerated in patients undergoing CABG surgery since higher thrombin levels in this setting may override the effects of PAR1 antagonism through PAR4

  14. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    -acting region of approximately 200 bp, called parC1, located between the two par loci. An additional cis-acting region, parC2, is located downstream of the parAB operon of par2. Here we show that ParR of par1 and ParB of par2 bind cooperatively to unrelated sets of direct repeats in parC1 to form the cognate...... partition and promoter repression complexes. Surprisingly, ParB repressed transcription of the noncognate par operon, indicating cross-talk and possibly epistasis between the two systems. The par promoters, P1 and P2, affected each other negatively. The DNA binding activities of ParR and ParB correlated...

  15. Accouchement par forceps: indications et pronostic materno-foetal ...

    African Journals Online (AJOL)

    L'accouchement par voie basse, peut être parfois compromis par des facteurs maternels, foetaux ou materno-foetaux nécessitant des moyens thérapeutiques comme le forceps pour achever l'accouchement par voie naturelle. Le forceps, une méthode qui n'est pas sans risque pour la mère et le nouveau-né. Nous avons ...

  16. Participación comunitaria en el control de las parasitosis intestinales en una localidad rural de Argentina Community participation in the control of intestinal parasitoses at a rural site in Argentina

    Directory of Open Access Journals (Sweden)

    Betina C. Pezzani

    2009-12-01

    Full Text Available OBJETIVOS: Diseñar, implementar y evaluar un plan complejo de acciones dirigido a reducir las parasitosis en una localidad rural de la provincia de Buenos Aires, Argentina, con la participación de la comunidad. MÉTODOS: El trabajo se realizó en General Mansilla, provincia de Buenos Aires, Argentina, en tres etapas. 1 Se evaluó la situación epidemiológica inicial de las parasitosis intestinales en la comunidad mediante análisis coproparasitológico seriado y de escobillado anal en una muestra de 522 personas. 2 Se implementaron dos intervenciones: el tratamiento farmacológico de las personas parasitadas y la educación sanitaria de la población con la participación activa de divulgadores locales. 3 El tratamiento antiparasitario se evaluó mediante análisis coproparasitológico de seguimiento de todas las personas tratadas; la intervención educativa se evaluó mediante una encuesta y análisis coproparasitológico a personas que solo habían participado en el plan de educación sanitaria. RESULTADOS: La frecuencia de parasitosis intestinal fue de 58,2%; del total, 43,9% por protozoos y 35,2% por helmintos. Los patógenos más frecuentes fueron Enterobius vermicularis, Blastocystis hominis y Giardia lamblia. El tratamiento antiparasitario redujo la parasitosis intestinal a 15,1% (P OBJECTIVES: To design, implement, and evaluate a complex plan of actions aimed at reducing parasitoses in a rural town in the province of Buenos Aires, Argentina, with the involvement of the community. METHODS: The project took place in General Mansilla, Buenos Aires province, in three stages. First, the initial epidemiological situation of intestinal parasitoses in the community was assessed by analyzing for parasites a series of stool samples and anal swabs taken from a sample of 522 individuals. Second, interventions were implemented: the pharmacological treatment of the infected individuals, and health education for the public involving local promoters

  17. The urokinase receptor (uPAR) and the uPAR-associated protein (uPARAP/Endo180)

    DEFF Research Database (Denmark)

    Behrendt, Niels

    2004-01-01

    processes involve a highly organized interplay between proteases and their cellular binding sites as well as specific substrates and internalization receptors. This review article is focused on two components, the urokinase plasminogen activator receptor (uPAR) and the uPAR-associated protein (uPARAP, also...... designated Endo180), that are considered crucially engaged in matrix degradation. uPAR and uPARAP have highly diverse functions, but on certain cell types they interact with each other in a process that is still incompletely understood. uPAR is a glycosyl-phosphatidylinositol-anchored glycoprotein...

  18. Taare Zameen Par and dyslexic savants

    Science.gov (United States)

    Chakravarty, Ambar

    2009-01-01

    The film Taare Zameen Par (Stars upon the Ground) portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ‘disinhibits’ the nondominant parietal lobe, unmasking talents—artistic or otherwise—in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations. PMID:20142854

  19. Taare Zameen Par and dyslexic savants

    Directory of Open Access Journals (Sweden)

    Chakravarty Ambar

    2009-01-01

    Full Text Available The film Taare Zameen Par (Stars upon the Ground portrays the tormented life at school and at home of a child with dyslexia and his eventual success after his artistic talents are discovered by his art teacher at the boarding school. The film hints at a curious neurocognitive phenomenon of creativity in the midst of language disability, as exemplified in the lives of people like Leonardo da Vinci and Albert Einstein, both of whom demonstrated extraordinary creativity even though they were probably affected with developmental learning disorders. It has been hypothesized that a developmental delay in the dominant hemisphere most likely ′disinhibits′ the nondominant parietal lobe, unmasking talents-artistic or otherwise-in some such individuals. It has been suggested that, in remedial training, children with learning disorders be encouraged to develop such hidden talents to full capacity, rather than be subjected to the usual overemphasis on the correction of the disturbed coded symbol operations.

  20. Investigation of APS PAR Vertical Beam Instability

    CERN Document Server

    Yao, Chihyuan; Sereno, Nicholas S; Yang Bing Xin

    2005-01-01

    The Advanced Photon Source (APS) particle accumulator ring (PAR) is a 325-MeV storage ring that collects and compresses linac pulse trains into a single bunch for booster injection. A vertical beam instability has been observed when only a single linac bunch is injected and the total beam charge is from 0.15 to 0.7 nC. The instability starts about 80 ms after the injection, lasts about 160 ms, and is highly reproducible. We performed spectral measurement and time-resolved imaging with both a gated-intensified camera and a streak camera in order to characterize this instability. Initial analysis of the data indicates that the instability is due to ion trapping. A stable lattice was established as result of the investigation. This report summarizes the experimental results and gives some preliminary analysis.

  1. PAR1 activation affects the neurotrophic properties of Schwann cells.

    Science.gov (United States)

    Pompili, Elena; Fabrizi, Cinzia; Somma, Francesca; Correani, Virginia; Maras, Bruno; Schininà, Maria Eugenia; Ciraci, Viviana; Artico, Marco; Fornai, Francesco; Fumagalli, Lorenzo

    2017-03-01

    Protease-activated receptor-1 (PAR1) is the prototypic member of a family of four G-protein-coupled receptors that signal in response to extracellular proteases. In the peripheral nervous system, the expression and/or the role of PARs are still poorly investigated. High PAR1 mRNA expression was found in the rat dorsal root ganglia and the signal intensity of PAR1 mRNA increased in response to sciatic nerve transection. In the sciatic nerve, functional PAR1 receptor was reported at the level of non-compacted Schwann cell myelin microvilli of the nodes of Ranvier. Schwann cells are the principal population of glial cells of the peripheral nervous system which myelinate axons playing an important role during axonal regeneration and remyelination. The present study was undertaken in order to determine if the activation of PAR1 affects the neurotrophic properties of Schwann cells. Our results suggest that the stimulation of PAR1 could potentiate the Schwann cell ability to favour nerve regeneration. In fact, the conditioned medium obtained from Schwann cell cultures challenged with a specific PAR1 activating peptide (PAR1 AP) displays increased neuroprotective and neurotrophic properties with respect to the culture medium from untreated Schwann cells. The proteomic analysis of secreted proteins in untreated and PAR1 AP-treated Schwann cells allowed the identification of factors differentially expressed in the two samples. Some of them (such as macrophage migration inhibitory factor, matrix metalloproteinase-2, decorin, syndecan 4, complement C1r subcomponent, angiogenic factor with G patch and FHA domains 1) appear to be transcriptionally regulated after PAR1 AP treatment as shown by RT-PCR. Copyright © 2017 Elsevier Inc. All rights reserved.

  2. TMS suppression of right pars triangularis, but not pars opercularis, improves naming in aphasia

    Science.gov (United States)

    Naeser, Margaret A.; Martin, Paula I.; Theoret, Hugo; Kobayashi, Masahito; Fregni, Felipe; Nicholas, Marjorie; Tormos, Jose M.; Steven, Megan S.; Baker, Errol H.; Pascual-Leone, Alvaro

    2011-01-01

    This study sought to discover if an optimum 1 cm2 area in the non-damaged right hemisphere (RH) was present, which could temporarily improve naming in chronic, nonfluent aphasia patients when suppressed with repetitive transcranial magnetic stimulation (rTMS). Ten minutes of slow, 1 Hz rTMS was applied to suppress different RH ROIs in eight aphasia cases. Picture naming and response time (RT) were examined before, and immediately after rTMS. In aphasia patients, suppression of right pars triangularis (PTr) led to significant increase in pictures named, and significant decrease in RT. Suppression of right pars opercularis (POp), however, led to significant increase in RT, but no change in number of pictures named. Eight normals named all pictures correctly; similar to aphasia patients, RT significantly decreased following rTMS to suppress right PTr, versus right POp. Differential effects following suppression of right PTr versus right POp suggest different functional roles for these regions. PMID:21864891

  3. Een jongeman met intestinale polyposis en epistaxis

    NARCIS (Netherlands)

    Menko, Fred H.; Jacobs, Maarten A. J. M.; Mager, Johannes J.; Nicolaï, Jan J.; Mensenkamp, Arjen R.; Aalfs, Cora M.

    2014-01-01

    Germline mutations in the SMAD4 gene lead to both juvenile polyposis syndrome and hereditary haemorrhagic telangiectasia (HHT). A 23-year-old man underwent colectomy with ileo-anal pouch anastomosis at the age of 12 due to colorectal juvenile polyposis. At follow-up, recurrent juvenile polyps in the

  4. Bacterial mitosis: partitioning protein ParA oscillates in spiral-shaped structures and positions plasmids at mid-cell

    DEFF Research Database (Denmark)

    Ebersbach, Gitte; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2004-01-01

    The par2 locus of Escherichia coli plasmid pB171 encodes oscillating ATPase ParA, DNA binding protein ParB and two cis-acting DNA regions to which ParB binds (parC1 and parC2). Three independent techniques were used to investigate the subcellular localization of plasmids carrying par2. In cells w...

  5. ParABS system in chromosome partitioning in the bacterium Myxococcus xanthus.

    Directory of Open Access Journals (Sweden)

    Antonio A Iniesta

    Full Text Available Chromosome segregation is an essential cellular function in eukaryotic and prokaryotic cells. The ParABS system is a fundamental player for a mitosis-like process in chromosome partitioning in many bacterial species. This work shows that the social bacterium Myxococcus xanthus also uses the ParABS system for chromosome segregation. Its large prokaryotic genome of 9.1 Mb contains 22 parS sequences near the origin of replication, and it is shown here that M. xanthus ParB binds preferentially to a consensus parS sequence in vitro. ParB and ParA are essential for cell viability in M. xanthus as in Caulobacter crescentus, but unlike in many other bacteria. Absence of ParB results in anucleate cells, chromosome segregation defects and loss of viability. Analysis of ParA subcellular localization shows that it clusters at the poles in all cells, and in some, in the DNA-free cell division plane between two chromosomal DNA masses. This ParA localization pattern depends on ParB but not on FtsZ. ParB inhibits the nonspecific interaction of ParA with DNA, and ParA colocalizes with chromosomal DNA only when ParB is depleted. The subcellular localization of ParB suggests a single ParB-parS complex localized at the edge of the nucleoid, next to a polar ParA cluster, with a second ParB-parS complex migrating after the replication of parS takes place to the opposite nucleoid edge, next to the other polar ParA cluster.

  6. The protein kinase SIK downregulates the polarity protein Par3

    DEFF Research Database (Denmark)

    Vanlandewijck, Michael; Dadras, Mahsa Shahidi; Lomnytska, Marta

    2018-01-01

    that SIK can potentially phosphorylate the polarity complex protein Par3, an established regulator of tight junction assembly. SIK associates with Par3, and induces degradation of Par3 that can be prevented by proteasomal and lysosomal inhibition or by mutation of Ser885, a putative phosphorylation site...... protein. HighSIKmRNA expression also correlates with lower chance for survival in various carcinomas. In specific human breast cancer samples, aneuploidy of tumor cells best correlated with cytoplasmic SIK distribution, and SIK expression correlated with TGFβ/Smad signaling activity and low...... or undetectable expression of Par3. Our model suggests that SIK can act directly on the polarity protein Par3 to regulate tight junction assembly....

  7. Recombination in the human Pseudoautosomal region PAR1.

    Directory of Open Access Journals (Sweden)

    Anjali G Hinch

    2014-07-01

    Full Text Available The pseudoautosomal region (PAR is a short region of homology between the mammalian X and Y chromosomes, which has undergone rapid evolution. A crossover in the PAR is essential for the proper disjunction of X and Y chromosomes in male meiosis, and PAR deletion results in male sterility. This leads the human PAR with the obligatory crossover, PAR1, to having an exceptionally high male crossover rate, which is 17-fold higher than the genome-wide average. However, the mechanism by which this obligatory crossover occurs remains unknown, as does the fine-scale positioning of crossovers across this region. Recent research in mice has suggested that crossovers in PAR may be mediated independently of the protein PRDM9, which localises virtually all crossovers in the autosomes. To investigate recombination in this region, we construct the most fine-scale genetic map containing directly observed crossovers to date using African-American pedigrees. We leverage recombination rates inferred from the breakdown of linkage disequilibrium in human populations and investigate the signatures of DNA evolution due to recombination. Further, we identify direct PRDM9 binding sites using ChIP-seq in human cells. Using these independent lines of evidence, we show that, in contrast with mouse, PRDM9 does localise peaks of recombination in the human PAR1. We find that recombination is a far more rapid and intense driver of sequence evolution in PAR1 than it is on the autosomes. We also show that PAR1 hotspot activities differ significantly among human populations. Finally, we find evidence that PAR1 hotspot positions have changed between human and chimpanzee, with no evidence of sharing among the hottest hotspots. We anticipate that the genetic maps built and validated in this work will aid research on this vital and fascinating region of the genome.

  8. Effects of thrombin, PAR-1 activating peptide and a PAR-1 antagonist on umbilical artery resistance in vitro

    Directory of Open Access Journals (Sweden)

    Elliott John T

    2005-02-01

    Full Text Available Abstract Background The non-thrombotic effects of thrombin in cardiovascular tissues, as mediated via the protease activated receptors (PARs, and particularly PAR-1, have been the focus of much recent research. The aims of this study were to evaluate the effects of thrombin, a specific PAR-1 activating peptide (PAR1-AP, and a PAR-1 antagonist on human umbilical artery tone in vitro. Methods Human umbilical artery samples were obtained from 17 women at term. Arterial rings were suspended under physiologic conditions for isometric recording. The in vitro effects of thrombin (0.5 units/mL to 3 units/mL, PAR1-AP TFLLR-NH2 [10(-9 to 10(-6 M], and PAR-1 antagonist (N-trans cinnamoyl- p-fluoroPhe-p-guanidinoPhe-Leu-Arg-Orn-NH2 [10(-9 M to 10(-5 M] on umbilical artery tone were measured. Results Both thrombin and TFLLR-NH2 exerted a potent cumulative vasodilatory effect on human umbilical artery resistance (P 0.05. Conclusion These findings highlight a potential role for thrombin and PAR-1 receptors in vascular regulation of feto-placental blood flow in normal pregnancy, and in association with the vascular lesions associated with IUGR and pre-eclampsia.

  9. Movement and equipositioning of plasmids by ParA filament disassembly

    DEFF Research Database (Denmark)

    Ringgaard, Simon; van Zon, Jeroen; Howard, Martin

    2009-01-01

    Bacterial plasmids encode partitioning (par) loci that confer stable plasmid inheritance. We showed previously that, in the presence of ParB and parC encoded by the par2 locus of plasmid pB171, ParA formed cytoskeletal-like structures that dynamically relocated over the nucleoid. Simultaneously......, the par2 locus distributed plasmids regularly over the nucleoid. We show here that the dynamic ParA patterns are not simple oscillations. Rather, ParA nucleates and polymerizes in between plasmids. When a ParA assembly reaches a plasmid, the assembly reaction reverses into disassembly. Strikingly......, plasmids consistently migrate behind disassembling ParA cytoskeletal structures, suggesting that ParA filaments pull plasmids by depolymerization. The perpetual cycles of ParA assembly and disassembly result in continuous relocation of plasmids, which, on time averaging, results in equidistribution...

  10. Limnological database for Par Pond: 1959 to 1980

    Energy Technology Data Exchange (ETDEWEB)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem.

  11. Limnological database for Par Pond: 1959 to 1980

    International Nuclear Information System (INIS)

    Tilly, L.J.

    1981-03-01

    A limnological database for Par Pond, a cooling reservoir for hot reactor effluent water at the Savannah River Plant, is described. The data are derived from a combination of research and monitoring efforts on Par Pond since 1959. The approximately 24,000-byte database provides water quality, primary productivity, and flow data from a number of different stations, depths, and times during the 22-year history of the Par Pond impoundment. The data have been organized to permit an interpretation of the effects of twenty years of cooling system operations on the structure and function of an aquatic ecosystem

  12. PSD-Constrained PAR Reduction for DMT/OFDM

    Science.gov (United States)

    Andgart, Niklas; Krongold, Brian S.; Ödling, Per; Johansson, Albin; Börjesson, Per Ola

    2004-12-01

    Common to all DMT/OFDM systems is a large peak-to-average ratio (PAR), which can lead to low power efficiency and nonlinear distortion. Tone reservation uses unused or reserved tones to design a peak-canceling signal to lower the PAR of a transmit block. In DMT ADSL systems, the power allocated to these tones may be limited due to crosstalk issues with many users in one twisted pair bundle. This PSD limitation not only limits PAR reduction ability, but also makes the optimization problem more challenging to solve. Extending the recently proposed active set tone reservation method, we develop an efficient algorithm with performance close to the optimal solution.

  13. Protease-activated receptor (PAR2, but not PAR1, is involved in collateral formation and anti-inflammatory monocyte polarization in a mouse hind limb ischemia model.

    Directory of Open Access Journals (Sweden)

    Lisa G van den Hengel

    Full Text Available AIMS: In collateral development (i.e. arteriogenesis, mononuclear cells are important and exist as a heterogeneous population consisting of pro-inflammatory and anti-inflammatory/repair-associated cells. Protease-activated receptor (PAR1 and PAR2 are G-protein-coupled receptors that are both expressed by mononuclear cells and are involved in pro-inflammatory reactions, while PAR2 also plays a role in repair-associated responses. Here, we investigated the physiological role of PAR1 and PAR2 in arteriogenesis in a murine hind limb ischemia model. METHODS AND RESULTS: PAR1-deficient (PAR1-/-, PAR2-deficient (PAR2-/- and wild-type (WT mice underwent femoral artery ligation. Laser Doppler measurements revealed reduced post-ischemic blood flow recovery in PAR2-/- hind limbs when compared to WT, while PAR1-/- mice were not affected. Upon ischemia, reduced numbers of smooth muscle actin (SMA-positive collaterals and CD31-positive capillaries were found in PAR2-/- mice when compared to WT mice, whereas these parameters in PAR1-/- mice did not differ from WT mice. The pool of circulating repair-associated (Ly6C-low monocytes and the number of repair-associated (CD206-positive macrophages surrounding collaterals in the hind limbs were increased in WT and PAR1-/- mice, but unaffected in PAR2-/- mice. The number of repair-associated macrophages in PAR2-/- hind limbs correlated with CD11b- and CD115-expression on the circulating monocytes in these animals, suggesting that monocyte extravasation and M-CSF-dependent differentiation into repair-associated cells are hampered. CONCLUSION: PAR2, but not PAR1, is involved in arteriogenesis and promotes the repair-associated response in ischemic tissues. Therefore, PAR2 potentially forms a new pro-arteriogenic target in coronary artery disease (CAD patients.

  14. Positron Accumulator Ring (PAR) power supply

    International Nuclear Information System (INIS)

    Fathizadeh, M.

    1995-01-01

    The Positron Accumulator Ring (PAR) consists of 8 dipole magnets connected in series. These magnets are energized via one 12-pulse dc power supply. The power supply consists of four phase controlled half-wave wye group converters. Each of the two half-wave converters are connected through an interphase transformer to obtain a full-wave converter with 120 degrees conduction. The input voltage for these two half-wave converters are 180 degrees apart. The two full-wave converters are connected in parallel through a third interphase transformer. This type of connection of the converters not only provides the required output current, it also improves the input power factor of the power supply. The output of the wye group converters is filtered through a passive L-R-C filter to reduce the ripple content of the output current. At low current values of the power supply the current ripple is high, thus a large filter is needed, which adds to the cost of the power supply, however at high output current levels, the current ripple is less severe. The large size of the filter can be reduced by adding an anti-parallel rectifier diode(D1) to the output of the power supply. A freewheeling diode(D2) is connected before the choke to circulate the current once the power supply is turned off. In order to measure the current in the magnet a high precision, low drift, zero flux current transductor is used. This transductor senses the magnet current which provides a feedback signal to control the gating of the converter's thyristors. A true 14 bit Digital to Analog Converter (DAC) is programmed by the control computer for the required current value, providing a reference for the current regulator. Fast correction of the line transients is provided by a relatively fast voltage loop controlled by a high gain slow response current loop

  15. Parálisis cerebral Cerebral palsy

    Directory of Open Access Journals (Sweden)

    Jorge Malagon Valdez

    2007-01-01

    Full Text Available El término parálisis cerebral (PC engloba a un gran número de síndromes neurológicos clínicos, de etiología diversa. Estos síndromes se caracterizan por tener una sintomatología común: los trastornos motores. Algunos autores prefieren manejar términos como "encefalopatía fija", "encefalopatías no evolutivas". Se mencionan la utilidad de programas de intervención temprana y métodos especiales de rehabilitación, así como el manejo de las deficiencias asociadas como la epilepsia, deficiencia mental, trastornos del lenguaje, audición, visión, déficit de la atención que mejoran el pronóstico de manera significativa. El pronóstico también depende de la gravedad del padecimiento y de las manifestaciones asociadas.The term cerebral palsy (CP, is used for a great number of clinical neurological syndromes. The syndromes are characterized by having a common cause, motor defects. It is important, because they can cause a brain damage by presenting motor defects and some associated deficiencies, such as mental deficiency, epilepsy, language and visual defects and pseudobulbar paralysis, with the nonevolving fact. Some authors prefer using terms such as "non-evolving encephalopathies". In the treatment the utility of prevention programs of early stimulation and special rehabilitation methods, and treatment of associated deficiencies such as epilepsy, mental deficiency, language, audition and visual problems, and the attention deficit improve the prognosis in an important way. The prognosis depends on the severity of the disease and the associated manifestations.

  16. Radiation retinopathy; Les retinopathies radio-induites

    Energy Technology Data Exchange (ETDEWEB)

    Lumbroso, L.; Desjardins, L. [Institut Curie, Serv. d' Ophtalmologie, 75 - Paris (France); Dendale, R.; Fourquet, A. [Institut Curie, Serv. de Radiotherapie, 75 - Paris (France)

    2002-09-01

    Radiation retinopathy is a retinal micro-angiopathy, observed after irradiation of the eye. It can rarely lead to neo-vascular glaucoma and enucleation due to pain. It is due to a progressive retinal capillary then vascular occlusion. Total irradiation dose, dose fraction, and surface of the irradiated retina seem to be strong predictive factors for radiation retinopathy. Patients who underwent an irradiation near the eye (skull base tumors, nasal and paranasal tumors, or brain tumors) should be followed by periodic ophthalmologic examination to detect and treat when necessary the non perfusion areas. (authors)

  17. First-in-human uPAR PET

    DEFF Research Database (Denmark)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive...... of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with (64)Cu...... for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of (64)Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment...

  18. La preuve apportée par les sciences

    Directory of Open Access Journals (Sweden)

    1997-04-01

    Full Text Available A propos d´une enquête menée par deux immunologistes de l´Université de Göteborg, rapportée par la très sérieuse revue Nature, le journal Le Monde n´hésitait pas à titrer : " La preuve du sexisme apportée par les sciences ". Les auteurs avaient en effet pu démontrer, irréfutables tests statistiques à l´appui, que, pour obtenir une bourse de post-doctorat offerte par le Swedisch Medical Research Council, les femmes devaient être deux fois et demie plus productives que les hommes ! Nous voulons...

  19. Croissance epitaxiale de GaAs sur substrats de Ge par epitaxie par faisceaux chimiques

    Science.gov (United States)

    Belanger, Simon

    La situation energetique et les enjeux environnementaux auxquels la societe est confrontee entrainent un interet grandissant pour la production d'electricite a partir de l'energie solaire. Parmi les technologies actuellement disponibles, la filiere du photovoltaique a concentrateur solaire (CPV pour concentrator photovoltaics) possede un rendement superieur et mi potentiel interessant a condition que ses couts de production soient competitifs. La methode d'epitaxie par faisceaux chimiques (CBE pour chemical beam epitaxy) possede plusieurs caracteristiques qui la rendent interessante pour la production a grande echelle de cellules photovoltaiques a jonctions multiples a base de semi-conducteurs III-V. Ce type de cellule possede la meilleure efficacite atteinte a ce jour et est utilise sur les satellites et les systemes photovoltaiques a concentrateur solaire (CPV) les plus efficaces. Une des principales forces de la technique CBE se trouve dans son potentiel d'efficacite d'utilisation des materiaux source qui est superieur a celui de la technique d'epitaxie qui est couramment utilisee pour la production a grande echelle de ces cellules. Ce memoire de maitrise presente les travaux effectues dans le but d'evaluer le potentiel de la technique CBE pour realiser la croissance de couches de GaAs sur des substrats de Ge. Cette croissance constitue la premiere etape de fabrication de nombreux modeles de cellules solaires a haute performance decrites plus haut. La realisation de ce projet a necessite le developpement d'un procede de preparation de surface pour les substrats de germanium, la realisation de nombreuses sceances de croissance epitaxiale et la caracterisation des materiaux obtenus par microscopie optique, microscopie a force atomique (AFM), diffraction des rayons-X a haute resolution (HRXRD), microscopie electronique a transmission (TEM), photoluminescence a basse temperature (LTPL) et spectrometrie de masse des ions secondaires (SIMS). Les experiences ont permis

  20. Prise en charge des intoxications par envenimation chez les enfants ...

    African Journals Online (AJOL)

    Les signes cliniques étaient dominés par les douleurs (98%) suivies des hémorragies (73,80%) pour les morsures de serpent, la douleur pour les piqures de scorpion (100%) et les oedèmes pour les piqures d'abeilles (100%). Les cas de morsure de serpent ont été traités par le sérum antivenimeux polyvalent. Conclusion: ...

  1. Analysis of ParB-centromere interactions by multiplex SPR imaging reveals specific patterns for binding ParB in six centromeres of Burkholderiales chromosomes and plasmids.

    Directory of Open Access Journals (Sweden)

    Flavien Pillet

    Full Text Available Bacterial centromeres-also called parS, are cis-acting DNA sequences which, together with the proteins ParA and ParB, are involved in the segregation of chromosomes and plasmids. The specific binding of ParB to parS nucleates the assembly of a large ParB/DNA complex from which ParA-the motor protein, segregates the sister replicons. Closely related families of partition systems, called Bsr, were identified on the chromosomes and large plasmids of the multi-chromosomal bacterium Burkholderia cenocepacia and other species from the order Burkholeriales. The centromeres of the Bsr partition families are 16 bp palindromes, displaying similar base compositions, notably a central CG dinucleotide. Despite centromeres bind the cognate ParB with a narrow specificity, weak ParB-parS non cognate interactions were nevertheless detected between few Bsr partition systems of replicons not belonging to the same genome. These observations suggested that Bsr partition systems could have a common ancestry but that evolution mostly erased the possibilities of cross-reactions between them, in particular to prevent replicon incompatibility. To detect novel similarities between Bsr partition systems, we have analyzed the binding of six Bsr parS sequences and a wide collection of modified derivatives, to their cognate ParB. The study was carried out by Surface Plasmon Resonance imaging (SPRi mulitplex analysis enabling a systematic survey of each nucleotide position within the centromere. We found that in each parS some positions could be changed while maintaining binding to ParB. Each centromere displays its own pattern of changes, but some positions are shared more or less widely. In addition from these changes we could speculate evolutionary links between these centromeres.

  2. Frequency of intestinal parasites and evaluation of methods for their diagnosis in a marginal community of Medellin, Colombia = Frecuencia de parásitos intestinales y evaluación de métodos para su diagnóstico en una comunidad marginal de Medellín, Colombia

    Directory of Open Access Journals (Sweden)

    Jaiberth Antonio Cardona Arias

    2013-07-01

    Full Text Available Background: Intestinal parasitism is still a public health problem. It has not been thoroughly studied in Medellin, Colombia. Objective: To determine the prevalence of intestinal parasites in residents of a marginal community in Medellin and to evaluate the validity, efficiency and reliability of direct examination in its diagnosis. Methods: Cross-sectional study and evaluation of diagnostic tests. Data were collected from a primary information source. Proportions with their confidence intervals were calculated; non-parametric statistical tests and analysis of sensitivity, specificity, predictive values, negative likelihood ratio and kappa were done. Results: Prevalence of parasites, according to the results of the concentration test, was 74.4%. Evaluation was done for intestinal parasites in general and for the following categories: protozoa, helminthes, commensals and pathogens. Sensitivity war over 68%, specificity and positive predictive value were 100%, negative predictive value was over 74%, negative likelihood ratio was less than 0.32, kappa was greater than 0.77 and efficiency was over 90%. Conclusion: Prevalence of intestinal parasitism is as high as it was three decades ago; its solution needs prompt and effective intervention of health authorities. The tests available for its study, including direct examination of stools, are of high diagnostic value.

  3. Attenuated vasodilator effectiveness of protease-activated receptor 2 agonist in heterozygous par2 knockout mice.

    Directory of Open Access Journals (Sweden)

    John C Hennessey

    Full Text Available Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo. However, there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET mice. The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout animals. In our study we aimed to determine the effects of intermediary par2 gene zygosity on vascular tissue responses to PAR2 activation. Specifically, we compared the vasodilator effectiveness of the PAR2 activating peptide 2-furoyl-LIGRLO-amide in aortas of wild-type PAR2 homozygous (PAR2-WT and PAR2-HET mice. In myographs under isometric tension conditions, isolated aortic rings were contracted by alpha 1-adrenoeceptor agonist (phenylephrine, and thromboxane receptor agonist (U46619 and then relaxation responses by the additions of 2-furoyl-LIGRLO-amide, acetylcholine, and nitroprusside were recorded. A Schild regression analysis of the inhibition by a PAR2 antagonist (GB-83 of PAR2 agonist-induced aortic ring relaxations was used to compare receptor expression in PAR2-WT to PAR2-HET. PAR2 mRNA in aortas was measured by quantitative real-time PCR. In aortas contracted by either phenylephrine or U46619, the maximum relaxations induced by 2-furoyl-LIGRLO-amide were less in PAR2-HET than in the gender-matched PAR2-WT. GB-83 was 3- to 4-fold more potent for inhibition of 2fly in PAR2-HET than in PAR2-WT. PAR2 mRNA content of aortas from PAR2-HET was not significantly different than in PAR2-WT. Acetylcholine- and nitroprusside-induced relaxations of aortas from PAR2-HET were not significantly different than in PAR2-WT and PAR2 knockout. An interesting secondary finding was that relaxations induced by agonists of PAR2 and muscarinic receptors were larger in females than in males. We conclude that the lower PAR2-mediated responses in PAR2-HET aortas are consistent with evidence of a lower quantity of functional

  4. Une terreur par l’image

    Directory of Open Access Journals (Sweden)

    Annie DULONG

    2011-09-01

    Full Text Available Si d’autres événements — Hiroshima, la découverte des camps de concentration, la chute du mur de Berlin — ont, au cours du XXe siècle, marqué suffisamment l’imaginaire pour trouver leur réponse dans des œuvres d’art, le 11 septembre 2001 pose la question de la fictionnalisation autrement : il ne s’agit plus tant de combler les manques de la représentation, liés à l’absence d’images ou au délai dans leur dévoilement, mais bien de composer avec l’omniprésence d’une représentation martelée à la télévision et sur Internet. Que cette représentation soit partielle, tronquée et qu’il lui manque la présence des corps, ces grands absents des photographies et des images tournées par les journalistes, ne change rien au fait que c’est avec le trop-plein que les artistes doivent maintenant négocier.Cet article s’intéresse aux romans qui traitent l’événement de front au lieu de l’aborder sur un mode mineur, et a pour objectif de tracer un portrait de la représentation des médias dans les romans du 11 septembre 2001. Ces romans, outre le fait qu’ils traitent des événements de New York, ont comme point commun un personnage, ou décor : les médias, représentés par la télévision, l’Internet, les photographies de presse, interviennent dans les récits d’une manière significative et témoignent de la force brute des images. À travers une étude de certains des mécanismes à l’œuvre dans The Writing on the Wall (Lynne Sharon Schwartz, Extremely Loud and Incredibly Close (Jonathan Safran Foer, Falling Man (Don DeLillo et A Disorder Peculiar to the Country (Ken Kalfus, il s’agira de proposer des réponses à ces quelques questions : quel rôle les médias jouent-ils, et comment participent-ils au récit ? Quelle pression les images exercent-elles sur les personnages ? Que révèlent les personnages enfants dans leur rapport aux médias ? Quelle critique, finalement, les romans

  5. Serum suPAR in patients with FSGS: trash or treasure?

    NARCIS (Netherlands)

    Maas, R.J.H.; Deegens, J.K.J.; Wetzels, J.F.M.

    2013-01-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both

  6. Par Pond vegetation status Summer 1995 -- June survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-06-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the shoreline aquatic plant communities in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level, indicated that much of the original plant communities and the intermediate shoreline communities present on the exposed sediments have been lost. The extensive old-field and emergent marsh communities that were present on the exposed shoreline during the drawdown have been flooded and much of the pre-drawdown Par Pond aquatic plant communities have not had sufficient time for re-establishment. The shoreline does, however, have extensive beds of maidencane which extend from the shoreline margin to areas as deep as 2 and perhaps 3 meters. Scattered individual plants of lotus and watershield are common and may indicate likely directions of future wetland development in Par Pond. In addition, within isolated coves, which apparently received ground water seepage and/or stream surface flows during the period of the Par Pond draw down, extensive beds of waterlilies and spike rush are common. Invasion of willow and red maple occurred along the lake shoreline as well. Although not absent from this survey, evidence of the extensive redevelopment of the large cattail and eel grass beds was not observed in this first survey of Par Pond. Future surveys during the growing seasons of 1995, 1996, and 1997 along with the evaluation of satellite date to map the areal extent of the macrophyte beds of Par Pond are planned

  7. Par Pond vegetation status Summer 1995 -- September survey descriptive summary

    International Nuclear Information System (INIS)

    Mackey, H.E. Jr.; Riley, R.S.

    1995-09-01

    The water level of Par Pond was lowered approximately 20 feet in mid-1991 in order to protect downstream residents from possible dam failure suggested by subsidence on the downstream slope of the dam and to repair the dam. This lowering exposed both emergent and nonemergent macrophyte beds to drying conditions resulting in extensive losses. A survey of the emergent shoreline aquatic plant communities began in June 1995, three months after the refilling of Par Pond to approximately 200 feet above mean sea level and continued with this mid-September survey. Communities similar to the pre-drawdown Par Pond aquatic plant communities are becoming re-established; especially, beds of maidencane, lotus, waterlily, and watershield are now extensive and well established. Cattail occurrence continues to increase, but large beds common to Par Pond prior to the drawdown have not formed. Future surveys during the late growing seasons of 1995, and throughout 1996 and 1997, along with the evaluation of satellite data to map the areal extent of the macrophyte beds of Par Pond, are planned

  8. Plasma suPAR is lowered by smoking cessation

    DEFF Research Database (Denmark)

    Eugen-Olsen, Jesper; Ladelund, Steen; Sørensen, Lars Tue

    2016-01-01

    , in smokers, predictive of long-term lung cancer development. Whether smoking cessation impacts the suPAR level is unknown. MATERIALS AND METHODS: Forty-eight smokers were randomized into three groups of 16: (i) continued to smoke 20 cigarettes per day, (ii) refrained from smoking and used transdermal...... nicotine patches and (iii) refrained from smoking and used placebo patches. Nonsmokers were included for comparison. suPAR and C-reactive protein (CRP) levels were measured by ELISA. RESULTS: At baseline, the suPAR level was significantly higher in the 48 smokers (median 3·2 ng mL, IQR (2·5-3·9)) than...... in 46 never smokers (1·9 ng/mL (1·7-2·2)). In smokers randomized to smoking cessation, suPAR levels after 4 weeks of stopping were decreased and no longer significantly different from the never smokers values. SuPAR decreased in both those who received a placebo as well as nicotine patch. Interestingly...

  9. Towards precision measurements of parity violation in cesium: construction of a new experiment using an active detection method by induced emission; Vers des mesures precises de violation de la parite dans le cesium: construction d'une experience nouvelle utilisant une detection active par emission induite

    Energy Technology Data Exchange (ETDEWEB)

    Jacquier, Ph

    1991-04-15

    Experiments that show the breaking of parity invariance in atoms can be considered as valid tests of the electroweak theory complementary to those made at high energies. The accurate measurement of the weak charge of a cesium nucleus would bring useful information on radiative corrections. The experiment, that is proposed in this work concerns the strongly forbidden 6S-7S transition of cesium at 540 nm, aims at reaching an accuracy of 1% for this measurement. Cesium atoms are first excited from 6S level to 7S level by a pulsed laser (10 ns) in the presence of a longitudinal electrical field. Then they are detected through induced emission by a probe laser set on 7S-6P(3/2) transition at 1.470 {mu}m. The transitory amplification of the probe beam can be over 100%.The vapour presents a strong plane dichroism due to the alignment of 7S level through the linear polarization of the pumping beam. The weak interaction in the atom makes this alignment tilt by a small angle (1 to 10 micro-radians) that the measurement of the polarization of the amplified probe enables us to determine. In this work we have described the 3 steps we have passed through: the test with a transverse field and a continuous laser beam, the use of a pulsed laser, and the setting of a longitudinal configuration. Preliminary results show that the experiment will be useful and feasible.

  10. Caractérisation numérique et expérimentale du champ magnétique B.F. généré par des systèmes électrotechniques en vue de la modélisation des courants induits dans le corps humain

    OpenAIRE

    Scorretti , Riccardo

    2003-01-01

    In the daily life, we are exposed to electromagnetic fields. One of the sources of these fields is the natural environment, but they are also dues to the increasing number of electrical appliances. Thus one is more and more concerned with the issue of the effects of this exposure on human health. The low frequency magnetic fields generate induced currents into the human body. These currents may produce some minor, reversible effects (phosphenes) for J=100mA/m2. On the other hand, the long-ter...

  11. One-nucleon transfer reactions induced by secondary beam of {sup 11}Be: study of the nuclear structure of the exotic nuclei {sup 11}Be and {sup 10}Li; Reactions de transfert d'un nucleon induites par un faisceau secondaire de {sup 11}Be: etude de la structure des noyaux exotiques {sup 11}Be et {sup 10}Li

    Energy Technology Data Exchange (ETDEWEB)

    Pita, S

    2000-09-01

    The structure of the neutron rich light nuclei {sup 11}Be and {sup 10}Li has been investigated by means of one nucleon transfer reactions. The experiments have been carried out at GANIL in inverse kinematics using {sup 11}Be secondary beams. The {sup 11}Be(p,d){sup 10}Be reaction bas been studied at 35.3 MeV/u. The {sup 10}Be ejectiles were analyzed by the spectrometer SPEG, and coincident deuterons were detected in the position sensitive silicon detector CHARISSA. Transfer cross sections to 0{sup +}{sub 1} and 2{sup +}{sub 1}, states in {sup 10}Be were measured up to {theta}{sub CM} = 16 deg. and compared to DWBA and CRC predictions. The effects of neutron-cure couplings on reaction form factors have been studied by solving coupled equations in the framework of a vibrational model. It is shown that the rate of core excitation {sup 10}Be{sub 2+} in the {sup 11}Be{sub gs} wave function is overestimated by a standard analysis with form factors given by the usual Separation Energy prescription. The former model predicts a rate of core excitation of 16% and leads to theoretical cross sections which are in good agreement with the experimental data. The aim of the {sup 11}Be(d,{sup 3}He){sup 10}Li experiment, realized at 37 MeV/u, was to measure the distribution of the 2s neutron strength in the unbound nucleus {sup 10}Li. The energy spectrum was deduced from the {sup 3}He energy and angle measured by the silicon strip detector array MUST. An asymmetric peak is clearly observed near the threshold, with a maximum at -S{sub n} = 130 keV. This constitutes a direct proof of the inversion of 2s and 1p{sub 1/2} shells in {sup 10}Li, which was until now a controversial question in spite of many experimental efforts. On the other band the analysis of the {sup 11}Be(d,t){sup 10}Be reaction studied in the same experiment confirms the results obtained in the {sup 11}Be(p,d){sup 10}Be reaction concerning the {sup 11}Be{sub gs} structure. This work shows the interest and feasibility of studies of the shell properties of exotic nuclei using transfer reactions induced by radioactive beams and constitutes the beginning of a program devoted to this kind of experiment. (author)

  12. Measurement of double differential cross sections for light charged particles production in neutron induced reaction at 62.7 MeV on lead target; Mesures des sections efficaces doublement differentielles de production de particules chargees legeres lors de reactions induites par neutrons de 62.7 MeV sur cible de plomb

    Energy Technology Data Exchange (ETDEWEB)

    Kerveno, M

    2000-09-27

    In order to develop new options for nuclear waste management, studies are carrying out on the perfecting of hybrid systems (sub-critical reactor driven by accelerator). This thesis work takes place more precisely in the framework of nuclear data linked to hybrid systems development. Increasing the upper limit energy value (from 20 to 150 MeV) of data bases supposes that theoretical codes could have sufficient predictive power in this energy range. Thus it's necessary to measure new cross sections to constrain these codes. The experiment, performed at Louvain-la-Neuve Cyclotron, aims to determine the double differential cross sections for light charged particles production in neutron induced reactions at 62.7 MeV on natural lead target. The detection device consists of 6 NE102-CsI telescopes. Time of flight measurements are used to reconstruct the neutron energy spectra. The general framework (hybrid systems and associated nuclear data problematic) in which this work takes place is presented in a first part. The experimental set up used for our measurements is described in a second part. The three following parts are dedicated to the data analysis and double differential cross sections extraction. The particle discrimination, the energy calibration of detectors as the different corrections applied to the experimental spectra are related in details. And finally a comparative study between our experimental results and some theoretical predictions is presented. (author)

  13. Dérégulations épigénétiques induites par la protéine fusion BRD4-NUT et caractérisation de la proteine NUT au cours de la spermatogenèse et dans les cancers

    OpenAIRE

    Reynoird , Nicolas

    2010-01-01

    Nowadays, it is clear that cancer cannot be reduced only to genetic abberations, and that a new parameter has to be considered, epigenetic. During my thesis, I have characterized the fusion protein BRD4-NUT, which results of a t(15;19) translocation observed in NUT midline carcinoma (NMC), highly aggressive and lethal. BRD4 contains a double bromodomain to interact with acetylated chromatin, thus recruting different complexes on chromatin. NUT is a protein of unknown function, specifically ex...

  14. Study of deuterons induced nuclear reactions on light elements (N, Al and Si): Application to containment materials of radioactive wastes; Etude des reactions nucleaires induites par des deuterons sur des elements legers (N, Al, Si): application aux materiaux de confinement des dechets radioactifs

    Energy Technology Data Exchange (ETDEWEB)

    Pellegrino, St

    2004-03-01

    Nuclear reaction analysis is well adapted to the quantification of light element. Profiles of concentration in order to follow elements migration into materials can be undertaken. This technique is used to study the behavior of the future matrices for nuclear waste containment. This technique is isotopic, characterized by a good signal-to-background ratio and a very low detection limit. The probability of a nuclear reaction is linked to a parameter called 'cross section' we have to know in order to carry out quantitative analysis. We have determined excitation curves for nitrogen, aluminium and silicon. These experiments were done with deuterons from 0.5 to 2 MeV. Two methods for the cross section characterization are presented and are in agreement with each other. The second one reduces uncertainty. Data are incorporated in the simulation software SIMNRA. We have compared the results obtained on different samples when we use data in literature or data of the study. We have noticed a great fit improvement with the data of this study. The new cross sections of this work will be integrated in the general data base SIGMABASE. Applications on materials such as Si{sub 3}N{sub 4}, nano-metric powders, WCN and nuclear glass YLaMgSiAlON studied for radioactive waste containment are also presented. (author)

  15. Intergranular brittle fracture of a low alloy steel induced by grain boundary segregation of impurities: influence of the microstructure; Rupture intergranulaire fragile d'un acier faiblement allie induite par la segregation d'impuretes aux joints de grains: influence de la microstructure

    Energy Technology Data Exchange (ETDEWEB)

    Raoul, St

    1999-07-01

    The study contributes to improve the comprehension of intergranular embrittlement induced by the phosphorus segregation along prior austenitic grain boundaries of low alloy steels used in pressurized power reactor vessel. A part of this study was performed using a A533 steel which contains chemical fluctuations (ghost lines) with two intensities. Axi-symmetrically notched specimens were tested and intergranular brittle de-cohesions were observed in the ghost lines. The fracture initiation sites observed on fracture surfaces were identified as MnS inclusions. A bimodal statistic obtained in a probabilistic model of the fracture is explained by the double population of ghost lines' intensities. A metallurgical study was performed on the same class of steel by studying the influence of the microstructure on the susceptibility to temper embrittlement. Brittle fracture properties of such microstructures obtained by dilatometric experiments were tested on sub-sized specimens to measure the V-notched fracture toughness. Fraction areas of brittle fracture modes were determined on surface fractures. A transition of the fracture mode with the microstructure is observed. It is shown that tempered microstructures of martensite and lower bainite are more susceptible to intergranular embrittlement than tempered upper bainitic microstructure. The intergranular fracture is the most brittle mode. The analysis of crystalline mis-orientations shows a grain boundary structure appreciably more coherent for tempered microstructures of martensite and lower bainite. The higher density of randomgrain boundaries is susceptible to drag the phosphorus in the upper bainitic matrix and to make the quantity of free phosphorus decreasing. Microstructure observations show a difference in the size and the spatial distribution of carbides, essentially cementite, between tempered martensite and upper bainite. It can explain the bigger susceptibility of this last microstructure to cleavage mode. (author)

  16. Measurement of cross-sections of fission reactions induced by neutrons on actinides from the thorium cycle at n-TOF facility; Mesures de sections efficaces de fission induite par neutrons sur des actinides du cycle du thorium a n-TOF

    Energy Technology Data Exchange (ETDEWEB)

    Ferrant, L

    2005-09-01

    In the frame of innovating energy source system studies, thorium fuel cycle reactors are considered. Neutron induced fission cross section on such cycle involved actinides play a role in scenario studies. To feed them, data bases are built with experimental results and nuclear models. For some nuclei, they are not complete or in disagreement. In order to complete these data bases, we have built an original set up, consisting in an alternation of PPACs (Parallel Plate Avalanche Chamber) and ultra - thin targets, which we installed on n-TOF facility. We describe detectors, set up, and the particular care brought to target making and characterization. Fission products in coincidence are detected with precise time measurement and localization with delay line read out method. We contributed, within the n-TOF collaboration, to the CERN brand new intense spallation neutron source characterization, based on time of flight measurement, and we describe its characteristics and performances. We were able to measure such actinide fission cross sections as {sup 232}Th, {sup 234}U, {sup 233}U, {sup 237}Np, {sup 209}Bi, and {sup nat}Pb relative to {sup 235}U et {sup 238}U standards, using an innovative acquisition system. We took advantage of the lame accessible energy field, from 0.7 eV to 1 GeV, combined with the excellent energy resolution in this field. Data treatment and analysis advancement are described to enlighten performance and limits of the obtained results. (author)

  17. Study of uranium dioxyde sputtering induced by multicharged heavy ions at low and very low kinetic energy: projectile charge effect; Etude de la pulverisation du dioxyde d'uranium induite par des ions lourds multicharges de basse et tres basse energie cinetique; effet de la charge du projectile

    Energy Technology Data Exchange (ETDEWEB)

    Haranger, F

    2003-12-01

    Ion beam irradiation of a solid can lead to the emission of neutral or ionized atoms, molecules or clusters from the surface. This comes as a result of the atomic motion in the vicinity of the surface, induced by the transfer of the projectile energy. Then, the study of the sputtering process appears as a means to get a better understanding of the excited matter state around the projectile trajectory. In the case of slow multicharged ions, a strong electronic excitation can be achieved by the projectile neutralization above the solid surface and / or its deexcitation below the surface. Parallel to this, the slowing down of such ions is essentially related to elastic collision with the target atoms. The study of the effect of the initial charge state of slow multicharged ions, in the sputtering process, has been carried out by measuring the absolute angular distributions of emission of uranium atoms from a uranium dioxide surface. The experiments have been performed in two steps. First, the emitted particles are collected onto a substrate during irradiation. Secondly, the surface of the collectors is analyzed by Rutherford Backscattering Spectrometry (RBS). This method allows the characterization of the emission of neutrals, which are the vast majority of the sputtered particles. The results obtained provide an access to the evolution of the sputtering process as a function of xenon projectile ions charge state. The measurements have been performed over a wide kinetic energy range, from 81 down to 1.5 keV. This allowed a clear separation of the contribution of the kinetic energy and initial projectile charge state to the sputtering phenomenon. (author)

  18. Cooperative photo-induced effects: from photo-magnetism under continuous irradiation to ultra-fast phenomena - study through optical spectroscopy and X-ray diffraction; Effets photo-induits cooperatifs: du photomagnetisme sous irradiation continue aux phenomenes ultrarapides - etude par spectroscopie optique et diffraction X

    Energy Technology Data Exchange (ETDEWEB)

    Glijer, D

    2006-12-15

    The control with ultra-short laser pulses of the collective and concerted transformation of molecules driving a macroscopic state switching on an ultra-fast time scale in solid state opens new prospects in materials science. The goal is to realize at the material level what happens at the molecular level in femto-chemistry. These processes are highly cooperative and highly non-linear, leading to self-amplification and self-organization within the material, a so-called photo-induced phase transition with a new long range order (structural, magnetic, ferroelectric,...). Two families of molecular compounds have been studied here: first of all, spin transition materials changing from a diamagnetic state over to a paramagnetic state under the effect of temperature or under continuous laser excitation. It concerns photo-active molecular bi-stability prototype materials in solid state, whose switching has been studied during X-ray diffraction, optical reflectivity and magnetism experiments. Then we have studied charge-transfer molecular systems, prototype compounds for ultrafast photo-induced phase transitions: insulator-metal, neutral-ionic....As well as ultrafast optical experiments, time-resolved X ray crystallography is a key technique in order to follow at the atomic level the different steps of the photo-induced transformation and thus to observe the involved mechanisms. We have underlined a process of photo-formation of one-dimensional nano-domains of lattice-relaxed charge-transfer excitations, governing the photo-induced phase transition of the molecular charge-transfer complex TTF-CA by the first time-resolved diffuse scattering measurements. Moreover, a new femtosecond laser-plasma source and a optical pump-probe spectroscopy set-up with a highly sensitive detecting system have been developed in this work. The results presented here will be an illustration of the present scientific challenges existing on the one hand with the development of projects of major scale (new ultrafast sources) and on the other hand with ultrafast photo-switching. (author)

  19. Monte-Carlo simulation of primary stochastic effects induced at the cellular level in boron neutron capture therapy; Simulation Monte-Carlo des effets stochastiques primaires induits au niveau cellulaire lors de la therapie par capture de neutrons sur le {sup 10}B

    Energy Technology Data Exchange (ETDEWEB)

    Cirioni, L.; Patau, J.P.; Nepveu, F. [Universite Paul Sabatier, 31 - Toulouse (France)

    1998-04-01

    A Monte Carlo code is developed to study the action of particles in Boron Neutron Capture Therapy (BNCT). Our aim is to calculate the probability of dissipating a lethal dose in cell nuclei. Cytoplasmic and nuclear membranes are considered as non-concentric ellipsoids. All geometrical parameters may be adjusted to fit actual configurations. The reactions {sup 10}B(n,{gamma} {alpha}){sup 7}Li and {sup 14}N(n,p) {sup 14}C create heavy ions which slow clown losing their energy. Their trajectories can be simulated taking into account path length straggling. The contribution of each reaction to the deposited dose in different cellular compartments can be studied and analysed for any distribution of {sup 10}B. (authors)

  20. Micro-seismicity induced by hydrocarbon production: contribution to localization of events and identification of the source mechanisms through the use of dynamic friction models; Contribution a la localisation des evenements et l'identification des mecanismes au foyer en micro-sismicite induite par l'exploitation d'hydrocarbures. Utilisation des modeles de frottement dynamique

    Energy Technology Data Exchange (ETDEWEB)

    Mohammedi, H.

    2002-11-01

    Oil production or any injection of fluid in a geological medium is likely to impose variations of stresses which might generate micro-seismicity. We examine whether the use of dynamic friction models could allow for a better determination of mechanics on the fault plane from borehole seismometers. We sought to identify the friction law model from seismogram observation. Before dealing with this inverse problem, we examined the direct problem generating synthetic seismograms at virtual stations, on the basis of a postulated friction law using the FD3D earthquake simulation code and the AXITRA radiation computation code. Treatment of two different laws, one of which is an original variation of the Dietrich-Ruina law, leads to similar seismograms. This might indicate that systematic inversion for the friction law only from seismogram observation might reveal difficult. (authors)

  1. Root uptake of uranium (6) in solution by a higher plant: speciation in hydroponic solution, bioavailability, micro-localisation and biological effects induced; Transfert racinaire de l'uranium (6) en solution chez une plante superieure: speciation en solution hydroponique, prise en charge par la plante, microlocalisation et effets biologiques induits

    Energy Technology Data Exchange (ETDEWEB)

    Laroche, L

    2005-01-15

    Uranium exists naturally in the environment, usually present in trace quantities. In soil solution and oxic conditions, uranium is present in the +VI oxidation state and forms a large number of inorganic and organic complexes. The exposure medium, an artificial soil solution, was designed in such a way as to control the uranium species in solution. The geochemical speciation code JCHESS was used to calculate the uranium aqueous species concentration and to define the domains of interest, each of them characterized by a limited number of dominant U species. These domains were defined as follows: pH 4.9 with uranyl ions as dominant species, pH 5.8 with hydroxyl complexes and pH 7 where carbonates play a major role. For each pH, short-duration (5 hours of exposure) well-defined laboratory experiments were carried out with Phaseolus vulgaris as plant model. The effect of competitive ions such as Ca{sup 2+} or the presence of ligands such as phosphate or citrate on root assimilation efficiency was explored. Results have shown that uranium transfer was not affected by the presence of calcium, phosphate or citrate (but was decreased of 60% with citrate (10 {mu}M) at pH 5.8) in our experimental conditions. Moreover, observation in Transmission Electronic Microscopy (TEM), equipped with an EDAX probe, have shown that uranium was associated with granules rich in phosphorus and that there were some chloroplast anomalies. Finally, the presence of uranium affects root CEC by reducing it and stimulates root elongation at low uranium concentrations (100 nM, 400 nM and 2 {mu}M at pHs 4.9, 5.8 and 7 respectively) and inhibits it at high uranium concentrations. (author)

  2. In vitro modulation of radiation-induced FAS-related apoptosis in CD34{sup +} progenitor cells by combination cytokines; Reduction de l'apoptose radio-induite impliquant le recepteur FAS au niveau des cellules hematopoietiques CD34{sup +} par une combinaison de cytokines

    Energy Technology Data Exchange (ETDEWEB)

    Drouet, M.; Mathieu, J.; Grenier, N.; Soutif, A.; Herodin, F

    1998-07-01

    Combination cytokines such as SCF, Flt-3 ligand, IL-3 and thrombopoietin can modulate Fas mRNA expression by in vitro irradiated CD34{sup +} cells which results in a moderate decrease of apoptotic ratio and an improved rate of clonogenicity of the irradiated progenitors. (authors)

  3. Investigation of double strand breaks induced by alpha particle irradiation using C.N.B.G. microbeam in human keratinocytes; Mise en evidence de cassures double brin de l'ADN induites par irradiation de keratinocytes humains en microfaisceau alpha

    Energy Technology Data Exchange (ETDEWEB)

    Pouthier, Th

    2006-12-15

    To understand the mechanisms of interaction of ionizing radiation with living tissues exposed to low and protracted doses remains a major issue for risk evaluation. The response cannot be found in epidemiological studies because the only available data concern accidental exposures to high doses of radiation. The natural exposure represents the main source of exposure in the daily life, just before the medical sources (radiology, radiotherapy). In addition, this kind of exposure is very difficult to reproduce in vitro by irradiating cell lines. The method per preference is based on random irradiation of cell populations. The mean number of particles having traversed cells is then calculated on the basis of Poisson statistics. In addition to inevitable multiple impacts, the numerous potential intracellular targets (nuclei, cytoplasm), the indirect effects induced by the impact of particles on neighbouring cells or simply the extracellular targets, constitute phenomena that make more complex the interpretation of experimental data. A charged particle microbeam was developed at C.E.N.B.G. to perform the targeted irradiation of individual cells with a targeting precision of a few microns. It is possible to deliver a counted number of alpha particles down to the ultimate dose of one alpha per cell, to target predetermined cells and then to observe the response of the neighbouring cells. This facility has been validated during this work on human keratinocyte cells expressing a recombinant nuclear fluorescent protein (histone H2B-GFP). The combination of ion micro-beams with confocal microscopy and numeric quantitative analysis allowed the measurement of DNA double strand breaks via the phosphorylation of the histone H2A.X in individual cells. The mechanisms of DNA reparation and apoptosis induction were also in the scope of those studies. The experimental results obtained during this thesis validate the methodology we have developed by demonstrating the targeting reproducibility and the dose control. A dose-effect relationship has been also investigated as a function of time. (author)

  4. Measurement of the fission cross section induced by fast neutrons of the {sup 232}Th/{sup 233}U nuclei within the innovating fuel cycles framework; Mesure de la section efficace de fission induite par neutrons rapides des noyaux {sup 232}Th/{sup 233}U dans le cadre des cycles de combustible innovants

    Energy Technology Data Exchange (ETDEWEB)

    Grosjean, C

    2005-03-15

    The thorium-U{sup 233} fuel cycle might provided safer and cleaner nuclear energy than the present Uranium/Pu fuelled reactors. Over the last 10 years, a vast campaign of measurements has been initiated to bring the precision of neutron data for the key nuclei (Th{sup 232}, Pa{sup 233} and U{sup 233}) at the level of those for the U-Pu cycle. This is the framework of these measurements, the energy dependent neutron induced fission cross section of Th{sup 232} and U{sup 233} has been measured from 1 to 7 MeV with a target accuracy lesser than 5 per cent. These measurements imply the accurate determination of the fission rate, the number of the target nuclei as well as the incident neutron flux impinging on the target, the latter has been obtained using the elastic scattering (n,p). The cross section of which is very well known in a large neutron energy domain ({approx} 0,5 % from 1 eV to 50 MeV) compared to the U{sup 235}(n,f) reaction. This technique has been applied for the first time to the Th{sup 232}(n,f) and U{sup 233}(n,f) cases. A Hauser-Feshbach statistical model has been developed. It consists of describing the different decay channels of the compound nucleus U{sup 234} from 0,01 to 10 MeV neutron energy. The parameters of this model were adjusted in order to reproduce the measured fission cross section of U{sup 233}. From these parameters, the cross sections from the following reactions could be extracted: inelastic scattering U{sup 233}(n,n'), radiative capture U{sup 233}(n,{gamma}) and U{sup 233}(n,2n). These cross sections are still difficult to measure by direct neutron reactions. The calculated values have allowed us to fill the lack of experimental data for the major fissile nucleus of the thorium cycle. (author)

  5. Mesures de taux de production d'éléments gazeux et volatiles lors de réactions induites par des protons de 1 et 1,4 GeV sur des cibles épaisses de plomb-bismuth liquides

    CERN Document Server

    Tall, Yoro

    2008-01-01

    The integrated project EUROTRANS (European Research Programme for the Transmutation of High Level Nuclear Waste in an Accelerator Driven System) of the 6th Euratom Framework Programme aims to demonstrate the transmutation of radioactive waste in ADS (Accelerator Driven Sub-critical system). It will carry out a first advanced design of an experimental facility to demonstrate the technical feasibility of transmutation, and will produce a conceptual design of an industrial facility dedicated to transmutation. An ADS consists of three fundamental elements: the accelerator of protons, the sub-critical core and the spallation target which one molten lead-bismuth concept is studied by the SUBATECH (physique SUBAtomique et des TECHnologies associées) laboratory in Nantes. The irradiation of molten lead-bismuth target with energetic proton beam generates volatile and radioactive residues. In order to determine experimentally the production rates of gas and volatile elements following a spallation reaction in a lead-b...

  6. Couches Minces de Titanate de Baryum Par Depot Organometallique

    Science.gov (United States)

    Ousi Benomar, Wahib

    1993-01-01

    Nous avons demontre la possibilite de realiser des couches minces de titanate de baryum par depot organometallique. Les films sont obtenus apres dissolution d'organometalliques choisis dans un solvant et une cuisson a une temperature determinee par thermogravimetrie. Apres un second traitement thermique a des temperatures plus elevees, les echantillons presentent une structure polycristalline tetragonale; les cristallites sont observes par microscopie electronique a balayage. La mesure de la constante dielectrique a permis de mettre en evidence une transition de phase de la structure tetragonale a la structure cubique a une temperature d'environ 125^circC. Les mesures d'indice ont ete effectuees. On note une augmentation de l'indice de refraction des films avec la temperature indiquant une meilleure densification des films. Nous avons aussi montre qu'il etait possible d'utiliser ce materiau en tant que guide d'onde optique pour pouvoir exploiter ses proprietes electrooptiques dans l'avenir.

  7. Ambroise Paré and 16th century neurosurgery.

    Science.gov (United States)

    Banerjee, Anirban Deep; Nanda, Anil

    2011-04-01

    The luminousness of Ambroise Paré, the surgeon-statesman, has withstood the ravages of time as the mark of a man, a hero, a surgeon-par-excellence, and above all, a benevolent philosopher. A self-made individual, his tryst with the art of surgery emanated from the literally non-stop battlefields of 16th century feudal Europe. Although a maverick in the medical world of his times; he rose from the humblest origins to the highest echelons solely as a result of his own genius and diligence. Among his mammoth contributions to the renaissance of surgery, Paré did perform many procedures which we see as neurosurgical, especially in the realms of neurotrauma and paediatric neurosurgery; the present vignette is an attempt to elucidate the same.

  8. [Ambroise Paré, his death and his historians].

    Science.gov (United States)

    Dumaître, P

    2001-01-01

    Ambroise Paré died December the 20th., 1590. What happened after his death and what are we knowing about his life? Never forgotten, though a lack of care, we were waiting till the XIXth. century to get recollection upon a subject sustained only by accounts of his travels. After Percy, a surgeon who tried to write Paré's biography through the "Biographie universelle ancienne et moderne, de Michaud (1822)" and some second rank authors, Malgaigne is the first who inside a printing of the "Oeuvres complétes de Paré (1840-41)" has a fine look upon the question, though his work is incomplete and allows many mistakes. Doctors Chéreau and Jal, an historian, analysing civil status records, gave new information enlarged by doctors Le Paulmier, Turner and the U.S. native Janet Doe.

  9. Pars Plana Vitrectomy in Treatment of Lens Injury

    Directory of Open Access Journals (Sweden)

    Remzi Avcı

    2013-01-01

    Full Text Available Lens injury due to traumas may present as loss of capsule integrity, cataract, lens subluxation, or lens luxation. In addition, lens subluxation and lens luxation may occur in pseudophakic patients due to trauma. Clear corneal, scleral or sclero-corneal phacoemulsification surgery, pars plana vitrectomy, pars plana vitrectomy with phaco-fragmentation, or pars plana vitrectomy with removal through corneal incision techniques are used in the treatment of lens injury due to traumas. Intraocular lens can be implanted in the bag, sulcus, or anterior chamber during the surgery. Depending on the circumstances, scleral fixated intraocular lenses or iris-claw lenses may also be preferred. Rehabilitation of such patients is not of a great concern today, with the advanced level of vitreoretinal surgery and cataract surgery techniques and with the current state of technology. (Turk J Ophthalmol 2013; 43: 51-4

  10. OXYDATION DU CYCLOHEXANE PAR COMPLEXE DE RUTHÉNIUM

    OpenAIRE

    HAMOUDI, Badreddine

    2008-01-01

    Le complexe RuCl2(PPh3)3 a été préparé dans le but de son application sur la réaction d’oxydation du cyclohexane en cyclhexanol et cyclohexanone. Les analyses par chromatographie en phase gaz sur la phase organique montrent la production de l’alcool et la cétone dans le cas du t-BuOOH comme oxydant, ce qui n’est le cas avec l’eau oxygénée et l’oxygène moléculaire. La réaction a été effectuée dans différents solvants, où l’eau a apportée une meilleure conversion par rapport a...

  11. Protease activated receptor-2 (PAR2): possible target of phytochemicals.

    Science.gov (United States)

    Kakarala, Kavita Kumari; Jamil, Kaiser

    2015-09-01

    The use of phytochemicals either singly or in combination with other anticancer drugs comes with an advantage of less toxicity and minimal side effects. Signaling pathways play central role in cell cycle, cell growth, metabolism, etc. Thus, the identification of phytochemicals with promising antagonistic effect on the receptor/s playing key role in single transduction may have better therapeutic application. With this background, phytochemicals were screened against protease-activated receptor 2 (PAR2). PAR2 belongs to the superfamily of GPCRs and is an important target for breast cancer. Using in silico methods, this study was able to identify the phytochemicals with promising binding affinity suggesting their therapeutic potential in the treatment of breast cancer. The findings from this study acquires importance as the information on the possible agonists and antagonists of PAR2 is limited due its unique mechanism of activation.

  12. PSD-Constrained PAR Reduction for DMT/OFDM

    Directory of Open Access Journals (Sweden)

    Krongold Brian S

    2004-01-01

    Full Text Available Common to all DMT/OFDM systems is a large peak-to-average ratio (PAR, which can lead to low power efficiency and nonlinear distortion. Tone reservation uses unused or reserved tones to design a peak-canceling signal to lower the PAR of a transmit block. In DMT ADSL systems, the power allocated to these tones may be limited due to crosstalk issues with many users in one twisted pair bundle. This PSD limitation not only limits PAR reduction ability, but also makes the optimization problem more challenging to solve. Extending the recently proposed active set tone reservation method, we develop an efficient algorithm with performance close to the optimal solution.

  13. La régulation des réseaux numériques par le contrat

    OpenAIRE

    Assoko, Héraclès Mayé

    2006-01-01

    Le développement des réseaux numériques dans la société moderne continue de susciter de nombreuses interrogations tenant essentiellement à l’encadrement juridique des activités y prenant place. La dimension planétaire du réseau Internet et la multiplicité de ses acteurs opère un dessaisissement des États dont les législations inadaptées apparaissent incompatibles avec l’évolution technologique des réseaux numériques. L’Internet induit donc une modification substantielle dans la normalisati...

  14. Keratometric alterations following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy.

    Science.gov (United States)

    Citirik, Mehmet; Batman, Cosar; Bicer, Tolga; Zilelioglu, Orhan

    2009-09-01

    To assess the alterations in keratometric astigmatism following the 25-gauge transconjunctival sutureless pars plana vitrectomy versus the conventional pars plana vitrectomy. Sixteen consecutive patients were enrolled into the study. Conventional vitrectomy was applied to eight of the cases and 25-gauge transconjunctival sutureless vitrectomy was performed in eight patients. Keratometry was performed before and after the surgery. In the 25-gauge transconjunctival sutureless pars plana vitrectomy group, statistically significant changes were not observed in the corneal curvature in any post-operative follow-up measurement (p > 0.05); whereas in the conventional pars plana vitrectomy group, statistically significant changes were observed in the first postoperative day (p = 0.01) and first postoperative month (p = 0.03). We noted that these changes returned to baseline in three months (p = 0.26). Both 25-gauge transconjunctival sutureless and conventional pars plana vitrectomy are effective surgical modalities for selected diseases of the posterior segment. Surgical procedures are critical for the visual rehabilitation of the patients. The post-operative corneal astigmatism of the vitrectomised eyes can be accurately determined at least two months post-operatively.

  15. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    present models for spectral and PAR (photosynthetically active radiation) attenuation in two contrasting Greenlandic fjords, Godthåbsfjord (SW Greenland) and Young Sound (NE Greenland). The fjords differ in the character and concentrations of optically active components present: dissolved organic material...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  16. Ejercicios activos en la parálisis facial

    OpenAIRE

    Bohoyo Aramburu, Cristina

    2013-01-01

    Diseño: Se trata de una revisión bibliográfica en la que se incluyen revisiones sistemáticas y artículos sobre el tratamiento de la parálisis facial mediante ejercicios faciales, que en su conjunto engloban lo que se denomina la “mímicoterapia”. Objetivos: el objetivo principal es determinar la eficacia de los ejercicios faciales activos en el tratamiento de la parálisis de Bell. El objetivo secundario es describir dichos ejercicios. Métodos: se ha realizado una búsqueda mediante la base d...

  17. Peptide-Based Optical uPAR Imaging for Surgery

    DEFF Research Database (Denmark)

    Juhl, Karina; Christensen, Anders; Persson, Morten

    2016-01-01

    Near infrared intra-operative optical imaging is an emerging technique with clear implications for improved cancer surgery by enabling a more distinct delineation of the tumor margins during resection. This modality has the potential to increase the number of patients having a curative radical......-AE105 tumor uptake by a bolus injection of the natural uPAR ligand pro-uPA, and finally 3) the histological colocalization of ICG-AE105 fluorescence and immunohistochemical detected human uPAR on resected tumor slides. Taken together, our data supports the potential use of this probe for intra...

  18. Den eneste ene - hvordan etniske minoritetsunge i Danmark danner par

    DEFF Research Database (Denmark)

    Singla, Rashmi

    Rapporten handler om etniske unges måde at danne par på. Rapporten er baseret på en større empirisk undersøgelse gennemført af forfatteren i 2003 og er desuden inspireret af forfatterens egen ph.d.-afhandling: "Ungdom, etnicitet og psychosocial intervention" (2000, Københavns Universitet). Rappor...

  19. Parasitisme des champs semenciers de cacaoyers par les ...

    African Journals Online (AJOL)

    SARAH

    30 janv. 2015 ... J. Appl. Biosci. Parasitisme des champs semenciers de cacaoyers par les loranthaceae dans la localité de Nkoemvone (sud Cameroun). 7795 to the various clones, Phragmanthera capitata was the most abundant Loranthaceae; the level of parasitism of cacao trees is more important at the cacao trees of ...

  20. La lecture de Merleau-Ponty par Renaud Barbaras

    Czech Academy of Sciences Publication Activity Database

    Pechar, Jiří

    2015-01-01

    Roč. 11, č. 2 (2015), s. 1-6 ISSN 1336-6556 Institutional support: RVO:67985955 Keywords : Merleau-Ponty * Husserl * phenomenology * linguistics of Ferdinand de Saussure Subject RIV: AA - Philosophy ; Religion http://www.ostium.sk/sk/la-lecture-de-merleau-ponty-par-renaud-barbaras/

  1. Approximation point par point pour la resolution du probleme de ...

    African Journals Online (AJOL)

    Approximation point par point pour la resolution du probleme de dirichlet dans un disque pour l'equation elliptique du second ordre a coefficients constants dans le cas ou les racines de l'equation caracteristique sont distinctes. AMJ Tchalla, K Tcharie ...

  2. Parálisis Facial en Enfermedad de Lyme

    OpenAIRE

    Gilberto Eduardo Marrugo Pardo; Melissa Vargas Márquez

    2015-01-01

    Presentamos el caso de un paciente de 23 meses de edad quien desarrollo parálisis facial unilateral secundaria a Enfermedad de Lyme sin síntomas otológicos previos y en Colombia que es considerada área no endémica.

  3. Ankaferd Blood Stopper induces apoptosis and regulates PAR1 and ...

    African Journals Online (AJOL)

    Mine Mumcuoglu

    2014-12-16

    Dec 16, 2014 ... b. , Nejat Akar c a LOSEV the Foundation for Children with Leukemia, Cancer Genetics Research Laboratory, Ankara, Turkey b LOSEV the Foundation for Children with Leukemia, .... 2 × 106 cells were counted and seeded into 25 cm2 flasks. .... ports the idea that there is a link between increases in PAR1.

  4. Efficacite et tolerance du captopril par voie sublinguale dans la ...

    African Journals Online (AJOL)

    insuffisance rénale chronique étaient les deux principales causes d'échec thérapeutique. Conclusion : Le captopril par voie sublinguale est donc aussi efficace chez le noir africain que chez le caucasien. Dans le contexte de pays en voie de ...

  5. Indications and Visual Outcome of First Hundred Pars Plana ...

    African Journals Online (AJOL)

    tulyasys

    Objective: To review the indications and visual outcome of the first one hundred pars plana vitrectomies performed at the newly established ... pre and postoperative visual acuity, indication for surgery and associated systemic or ocular co-morbidities of first hundred ..... Source of Support: Nil, Conflict of Interest: None declared.

  6. Indications and visual outcome of first hundred pars plana ...

    African Journals Online (AJOL)

    Conclusion: Rhegmatogenous retinal detachment and vitreous hemorrhage are the major indications for pars plana vitrectomy in this environment. As vitreoretinal disorders have become more common in this part of the world, there would be a corresponding increase in demand for vitreoretinal services. There is therefore a ...

  7. Radiative transfer code: Application to the calculation of PAR

    Indian Academy of Sciences (India)

    solar radiation as vector flux rather than PAR leads to an underestimate of the primary production up to ... The production of carbon in the ocean, the so-called .... ments, bchla, are very difficult to measure experimen- tally. Usually, we use a bio-optical model to derive bchla from the concentration of chlorophyll ''a'' pigment.

  8. parC Mutations in Fluoroquinolone-Resistant Borrelia burgdorferi

    OpenAIRE

    Galbraith, Kendal M.; Ng, Amanda C.; Eggers, Betsy J.; Kuchel, Craig R.; Eggers, Christian H.; Samuels, D. Scott

    2005-01-01

    We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent, Borrelia burgdorferi. Mutations in parC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.

  9. Parálisis Facial en Enfermedad de Lyme

    Directory of Open Access Journals (Sweden)

    Gilberto Eduardo Marrugo Pardo

    2015-01-01

    Full Text Available Presentamos el caso de un paciente de 23 meses de edad quien desarrollo parálisis facial unilateral secundaria a Enfermedad de Lyme sin síntomas otológicos previos y en Colombia que es considerada área no endémica.

  10. The Pars Triangularis in Dyslexia and ADHD: A Comprehensive Approach

    Science.gov (United States)

    Kibby, Michelle Y.; Kroese, Judith M.; Krebbs, Hillery; Hill, Crystal E.; Hynd, George W.

    2009-01-01

    Limited research has been conducted on the structure of the pars triangularis (PT) in dyslexia despite functional neuroimaging research finding it may play a role in phonological processing. Furthermore, research to date has not examined PT size in ADHD even though the right inferior frontal region has been implicated in the disorder. Hence, one…

  11. Apoplejía pituitaria con parálisis del III par craneal: Reporte de caso

    Directory of Open Access Journals (Sweden)

    Miguel Pinto Valdivia

    2011-10-01

    Full Text Available Se describe el caso de un varón de 65 años de edad, sin antecedentes patológicos de importancia, que acudió a emergencia del Hospital Nacional Cayetano Heredia por presentar cefalea intensa y ptosis palpebral izquierda. El examen físico mostró parálisis aislada del III par craneal izquierdo. Los análisis de laboratorio mostraron hiponatremia e hipopituitarismo y la resonancia magnética nuclear un adenoma pituitario con áreas de hemorragia e invasión de los senos cavernosos. El tratamiento incluyó glucocorticoides y descompresión quirúrgica transesfenoidal. La anatomía patológica confirmó el diagnóstico de infarto hemorrágico de un adenoma pituitario. El paciente fue dado de alta con terapia sustitutiva de levotiroxina y prednisona. La ptosis palpebral izquierda se recuperó en forma parcial. La apoplejía pituitaria es un síndrome clínico producido por un proceso expansivo dentro de la silla turca, secundario a hemorragia o infarto de un adenoma pituitario, que se caracteriza por cefalea, déficit visual, oftalmoplejía y alteración del nivel de conciencia. Este proceso expansivo puede comprimir los pares craneales en los senos cavernosos, produciendo diferentes grados de parálisis de los músculos oculomotores. La parálisis aislada del III par craneal es rara.(Rev Med Hered 2011;22:186-189.

  12. First (18)F-labeled ligand for PET imaging of uPAR

    DEFF Research Database (Denmark)

    Persson, Morten; Liu, Hongguang; Madsen, Jacob

    2013-01-01

    Urokinase-type plasminogen activator receptor (uPAR) is overexpressed in human prostate cancer and uPAR has been found to be associated with metastatic disease and poor prognosis. AE105 is a small linear peptide with high binding affinity to uPAR. We synthesized an N-terminal NOTA-conjugated vers...

  13. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    DEFF Research Database (Denmark)

    Bache, Michael; Bosco, Filippo; Brøgger, Anna Line

    2013-01-01

    of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable...

  14. Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.

    Science.gov (United States)

    Rwibasira Rudinga, Gamariel; Khan, Ghulam Jilany; Kong, Yi

    2018-02-14

    Cardiovascular diseases (CVDs) are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs), including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR). Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  15. Protease-Activated Receptor 4 (PAR4: A Promising Target for Antiplatelet Therapy

    Directory of Open Access Journals (Sweden)

    Gamariel Rwibasira Rudinga

    2018-02-01

    Full Text Available Cardiovascular diseases (CVDs are currently among the leading causes of death worldwide. Platelet aggregation is a key cellular component of arterial thrombi and major cause of CVDs. Protease-activated receptors (PARs, including PAR1, PAR2, PAR3 and PAR4, fall within a subfamily of seven-transmembrane G-protein-coupled receptors (GPCR. Human platelets express PAR1 and PAR4, which contribute to the signaling transduction processes. In association with CVDs, PAR4 not only contributes to platelet activation but also is a modulator of cellular responses that serve as hallmarks of inflammation. Although several antiplatelet drugs are available on the market, they have many side effects that limit their use. Emerging evidence shows that PAR4 targeting is a safer strategy for preventing thrombosis and consequently may improve the overall cardiac safety profile. Our present review summarizes the PAR4 structural characteristics, activation mechanism, role in the pathophysiology of diseases and understanding the association of PAR4 targeting for improved cardiac protection. Conclusively, this review highlights the importance of PAR4 antagonists and its potential utility in different CVDs.

  16. Design, construction, and wire calibration of PAR BPM striplines

    International Nuclear Information System (INIS)

    Sellyey, W.; Barr, D.; Erwin, L.

    1994-01-01

    The Positron Accumulator Ring (PAR) is part of the APS injection system. It receives 24 30-ns FWHM bursts of 450-MeV positrons, and compresses them into 6-nC, 290-ps rms bunches. Striplines were selected as beam position monitors (BPMs) to assure that good position sensitivity is achieved. This paper will describe the design, construction, and wire calibration of the 16 PAR BPMs. It will be demonstrated that all relevant stripline parameters can be determined by solving the two-dimensional LaPlace equation. This was done numerically using the electrostatic part of the PE2D computer program. The construction of the units will be briefly discussed. Wire calibration data on one of the final units will be compared with theory at four frequencies

  17. A Pipeline for PAR-CLIP Data Analysis.

    Science.gov (United States)

    Jens, Marvin

    2016-01-01

    Photo-activatable ribonucleoside cross-linking and immunoprecipitation (PAR-CLIP) is a method to detect binding sites of RNA-binding proteins (RBPs) transcriptome-wide. This chapter covers the computational analysis of the high-throughput sequencing reads generated from PAR-CLIP experiments. It explains how the reads are mutated due to UV cross-linking and how to appropriately pre-process and align them to a reference sequence. Aligned reads are then aggregated into clusters which represent putative RBP-binding sites. Mapping artifacts are a source of false positives, which can be controlled by means of a mapping decoy and adaptive quality filtering of the read clusters. A step-by-step explanation of this procedure is given. All necessary tools are open source, including the scripts presented and used in this chapter.

  18. Démarginalisation des travailleurs pauvres par le droit | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Démarginalisation des travailleurs pauvres par le droit. Cette subvention appuiera une étude approfondie de la situation, des revendications et des combats juridiques des travailleurs pauvres (plus particulièrement des femmes) membres de l'économie non structurée au Ghana, au Pérou et en Thaïlande. On aura recours à ...

  19. Contribution de la tomographie par coherence optique au diagnostic ...

    African Journals Online (AJOL)

    La tomographie par cohérence optique (OCT) est devenue un outil diagnostique très important en neurophtalmologie. Dans un grand nombre de cas, le profil OCT apporte à la fois une aide diagnostique et une évaluation de l'importance de la neuropathie optique. Parmi les étiologies de la neuropathie optique, il y a la ...

  20. Inondations dans la banlieue de Dakar : vers une adaptation par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Inondations dans la banlieue de Dakar : vers une adaptation par des améliorations du bâti, des infrastructures et de la gouvernance locale. La gestion des inondations représente un des défis majeurs du continent africain en regard des changements climatiques. Une urbanisation effrénée, un étalement urbain hors de ...

  1. Traitement De La Peripneumonie Contagieuse Bovine Par L ...

    African Journals Online (AJOL)

    Traitement De La Peripneumonie Contagieuse Bovine Par L'oxyteTracycline Longe Action Et Transmission Experimentale de la Maladie A Partir de Bovins Traites. ... Tous les 14 animaux ont séroconverti et l'analyse post-mortem a montré la présence des lésions chroniques dont des séquestres pulmonaires chez 4 d'entre ...

  2. Candido: Uma Leitura Paródica de Candide

    Directory of Open Access Journals (Sweden)

    Maria Gloria Cusumano Mazzi

    2010-12-01

    Full Text Available O presente artigo estuda a leitura paródica que Leonardo Sciascia (1921-1989 faz de Voltaire (1694-1778 mediante o cotejo das obras: o hipertexto Candido ovvero Un sogno fatto in Sicilia (1977 e o hipotexto Candide ou l’optimisme (1759. Apresenta ainda outra possibilidade de leitura, ou seja, Candido como metáfora da própria intertextualidade.

  3. Solution volumes finis polynomiale par morceaux pour les ...

    African Journals Online (AJOL)

    Nous présentons dans ce papier un concept de solution volumes finis continue pour des problèmes de diffusion-convection avec des données régulières. Nous comparons dans certains cas particuliers la solution proposée avec la solution volumes finis classiques (qui est une fonction constante par morceaux) et la ...

  4. Epuration des effluents industriels par électroflottation Belkacem ...

    African Journals Online (AJOL)

    d'absorption atomique SAA (Shimadzu,. Japan) [26,27]. 3. RESULTATS ET DISCUSSIONS. En électroflottation avec des électrodes en aluminium, l'anode émet les ions Al3+. , causant la neutralisation de la charge extérieure des particules (du potentiel zêta) dans l'eau. La cathode produit le gaz. H2. (par électrolyse), ayant ...

  5. Tuberculose lymphonodale cervicale chez les enfants vaccines par ...

    African Journals Online (AJOL)

    La tuberculose ganglionnaire cervicale est une localisation extrapulmonaire relativement fréquente chez l'enfant. Elle pose essentiellement des difficultés de prévention. L'objectif de ce travail est d'étudier les particularités diagnostiques et thérapeutiques chez des enfants vaccinés par le BCG. Matériel et méthodes: Nôtre ...

  6. La parálisis cerebral en el contexto escolar /

    OpenAIRE

    Rodríguez Gimeno, Ignacio

    2012-01-01

    Se analiza el concepto de parálisis cerebral, los diferentes tipos y sus características. También las adaptaciones que se deben realizar a nivel de centro, de aula, y a nivel individual para estos alumnos, conocer los diferentes sistemas alternativos y aumentativos de comunicación y aplicar las ayudas técnicas que precisa este alumnado

  7. MYRINGOPLASTIE PAR LA TECHNIQUE DES BOUTONNIÈRES

    African Journals Online (AJOL)

    Le but de ce travail est de rapporter nos résultatsde myringoplastie par la technique des boutonnières, chez des patients porteurs ... (4,08%), la latéralisation dans 1 cas (2,04%), le blunting ou comblement de l'angle antérieur tympano-méatal dans 1 cas. (2,04%) ..... permettent qu'un contact limité entre le greffon et les reli-.

  8. Adoption d'innovations agricoles par le truchement de services ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    L'agriculture est le fer de lance de nombreuses économies en développement, mais la capacité des petits agriculteurs privés de ressources à adopter des innovations agricoles est freinée par le manque d'accès à des services financiers adéquats. Des experts internationaux estiment qu'il existe un manque à gagner ...

  9. Facteurs predictifs de mortalite par accident vasculaire cerebral ...

    African Journals Online (AJOL)

    Description Les AVC constituent un problème de santé publique avec une mortalité élevée. Objectif Identifier les facteurs prédictifs de mortalité par accidents vasculaires cérébraux à la Clinique Neurologique du CHU de Fann, Dakar. Méthodes Il s'agit d'une étude rétrospective du 1er Janvier 2001 au 01 Novembre 2003 ...

  10. Protease activated receptors (PARS) mediation in gyroxin biological activity

    International Nuclear Information System (INIS)

    Silva, Jose Alberto Alves da

    2009-01-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH 2 , respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  11. La modélisation par Reverse Monte Carlo (RMC)

    Science.gov (United States)

    McGreevy, R. L.

    2003-09-01

    La technique de modélisation par Reverse Monte Carlo (RMC) est une méthode générale de modélisation structurale à partir d'un ensemble de données expérimentales. Cette méthode étant très souple, elle peut s'appliquer à de nombreux types de données. Jusqu'à présent ces applications comprennent : la diffraction des neutrons (y compris la substitution isotopique), la diffraction des rayons X (y compris la diffusion anomale), la diffraction des électrons, la RMN (les techniques d'angle magique et de 2ème moment) et l'EXAFS. Les systèmes étudiés sont également d'une grande variété : liquides, verres, polymères, cristaux et matériaux magnétiques, par exemple. Ce cours présente les bases de la méthode RMC en signalant certaines des idées fausses répandues. L'accent sera mis sur le fait que les modèles structuraux obtenus par RMC ne sont ni'uniques' ni 'exacts' ; cependant ils sont souvent utiles à la compréhension soit de la structure du système, soit des relations entre structure et autres propriétés physiques.

  12. Macroinvertebrates of Par Pond and Pond B: Final report, January 1984-June 1985

    Energy Technology Data Exchange (ETDEWEB)

    Kondratieff, B.C.; Chimney, M.J.; Painter, W.B.

    1985-08-01

    This document reports on the Par Pond and Pond B macroinvertebrate sampling program from January 1984 through June 1985. It includes data on quantitative and qualitative benthic sampling, quantitative meroplankton sampling and quarterly diel sample. The basic objectives were to: (1) characterize the benthic and meroplankton macroinvertebrate communities of Par Pond and Pond B, with respect to taxonomic composition and diversity, density and relative abundance of functional feeding groups; (2) assess the impact of thermal discharges on the macroinvertebrate community of Par Pond; (3) assess the impact and significance of entrainment losses of macroinvertebrate meroplankton from Par Pond; and (4) compare Par Pond macroninvertebrate communities with those in Pond B.

  13. Expression of Partitioning Defective 3 (Par-3 for Predicting Extrahepatic Metastasis and Survival with Hepatocellular Carcinoma

    Directory of Open Access Journals (Sweden)

    Jun-Yang Liou

    2013-01-01

    Full Text Available Partitioning defective 3 (Par-3, a crucial component of partitioning-defective complex proteins, controls cell polarity and contributes to cell migration and cancer cell epithelial-to-mesenchymal transition. However, the clinical relevance of Par-3 in tumor progression and metastasis has not been well elucidated. In this study, we investigated the impact and association of Par-3 expression and clinical outcomes with hepatocellular carcinoma (HCC. We first confirmed that Par-3 was abundantly expressed in HCC cell lines by Western blot analysis. We used immunohistochemistry to analyze the association of Par-3 expression and clinicopathological characteristics in primary and subsequent metastatic tumors of patients with HCC. Par-3 was overexpressed in 47 of 111 (42.3% primary tumors. Increased expression of Par-3 in primary tumors predicted an increased five-year cumulative incidence of extrahepatic metastasis. In addition, multivariate analysis revealed that Par-3 overexpression was an independent risk factor of extrahepatic metastasis. Increased Par-3 expression in primary tumors was associated with poor five-year overall survival rates and was an independent prognostic factor on Cox regression analysis. In conclusion, we show for the first time that increased Par-3 expression is associated with distant metastasis and poor survival rates in patients with HCC. Par-3 may be a novel prognostic biomarker and therapeutic target for HCC.

  14. Proteinase-Activated Receptor 1 (PAR1) regulates leukemic stem cell functions.

    Science.gov (United States)

    Bäumer, Nicole; Krause, Annika; Köhler, Gabriele; Lettermann, Stephanie; Evers, Georg; Hascher, Antje; Bäumer, Sebastian; Berdel, Wolfgang E; Müller-Tidow, Carsten; Tickenbrock, Lara

    2014-01-01

    External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  15. Proteinase-Activated Receptor 1 (PAR1 regulates leukemic stem cell functions.

    Directory of Open Access Journals (Sweden)

    Nicole Bäumer

    Full Text Available External signals that are mediated by specific receptors determine stem cell fate. The thrombin receptor PAR1 plays an important role in haemostasis, thrombosis and vascular biology, but also in tumor biology and angiogenesis. Its expression and function in hematopoietic stem cells is largely unknown. Here, we analyzed expression and function of PAR1 in primary hematopoietic cells and their leukemic counterparts. AML patients' blast cells expressed much lower levels of PAR1 mRNA and protein than CD34+ progenitor cells. Constitutive Par1-deficiency in adult mice did not affect engraftment or stem cell potential of hematopoietic cells. To model an AML with Par1-deficiency, we retrovirally introduced the oncogene MLL-AF9 in wild type and Par1-/- hematopoietic progenitor cells. Par1-deficiency did not alter initial leukemia development. However, the loss of Par1 enhanced leukemic stem cell function in vitro and in vivo. Re-expression of PAR1 in Par1-/- leukemic stem cells delayed leukemogenesis in vivo. These data indicate that Par1 contributes to leukemic stem cell maintenance.

  16. Nuclear movement during myotube formation is microtubule and dynein dependent and is regulated by Cdc42, Par6 and Par3

    OpenAIRE

    Cadot, Bruno; Gache, Vincent; Vasyutina, Elena; Falcone, Sestina; Birchmeier, Carmen; Gomes, Edgar R

    2012-01-01

    Mono-nucleated myoblasts fuse to form multi-nucleated myotubes. After the fusion, the myoblast nucleus moves towards the centre of the myotube. This movement is driven by microtubules and dynein, and is regulated by Cdc42, Par6 and Par3.

  17. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All ...

  18. The double par locus of virulence factor pB171: DNA segregation is correlated with oscillation of ParA

    DEFF Research Database (Denmark)

    Ebersbach, G; Gerdes, K; Charbon, Gitte Ebersbach

    2001-01-01

    Prokaryotic plasmids and chromosomes encode partitioning (par) loci that segregate DNA to daughter cells before cell division. Recent database analyses showed that almost all known par loci encode an ATPase and a DNA-binding protein, and one or more cis-acting regions where the proteins act. All...

  19. Serum suPAR in patients with FSGS: trash or treasure?

    Science.gov (United States)

    Maas, Rutger J H; Deegens, Jeroen K J; Wetzels, Jack F M

    2013-07-01

    The urokinase-type plasminogen activator receptor (uPAR) has important functions in cell migration. uPAR can be shed from the cell membrane resulting in soluble uPAR (suPAR). Further cleavage gives rise to shorter fragments with largely unknown functions. Recent studies have demonstrated that both overexpression of uPAR on podocytes and the administration of suPAR cause proteinuria in mice. The common pathogenic mechanism involves the activation of podocyte β3-integrin. Increased activation of β3-integrin is also observed in patients with focal and segmental glomerulosclerosis (FSGS). These observations form the basis for the hypothesis that suPAR may be the circulating factor causing FSGS. A recent study fosters this idea by demonstrating increased suPAR levels in the serum of patients with FSGS and reporting an association with recurrence after transplantation and response to plasmapheresis. However, this study was heavily biased, and subsequent studies have given conflicting results. Although the experimental work is very suggestive, at present there is no proof that any known human suPAR fragment causes FSGS in humans. We therefore suggest that the measurement of suPAR using currently available assays has absolutely no value at the present time in decision-making in routine clinical practice.

  20. Structures of actin-like ParM filaments show architecture of plasmid-segregating spindles.

    Science.gov (United States)

    Bharat, Tanmay A M; Murshudov, Garib N; Sachse, Carsten; Löwe, Jan

    2015-07-02

    Active segregation of Escherichia coli low-copy-number plasmid R1 involves formation of a bipolar spindle made of left-handed double-helical actin-like ParM filaments. ParR links the filaments with centromeric parC plasmid DNA, while facilitating the addition of subunits to ParM filaments. Growing ParMRC spindles push sister plasmids to the cell poles. Here, using modern electron cryomicroscopy methods, we investigate the structures and arrangements of ParM filaments in vitro and in cells, revealing at near-atomic resolution how subunits and filaments come together to produce the simplest known mitotic machinery. To understand the mechanism of dynamic instability, we determine structures of ParM filaments in different nucleotide states. The structure of filaments bound to the ATP analogue AMPPNP is determined at 4.3 Å resolution and refined. The ParM filament structure shows strong longitudinal interfaces and weaker lateral interactions. Also using electron cryomicroscopy, we reconstruct ParM doublets forming antiparallel spindles. Finally, with whole-cell electron cryotomography, we show that doublets are abundant in bacterial cells containing low-copy-number plasmids with the ParMRC locus, leading to an asynchronous model of R1 plasmid segregation.

  1. Envenimation mortelle par morsure de serpent chez une femme ...

    African Journals Online (AJOL)

    Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l'évolution a été marquée par l'installation d'un oedème cervico-facial nécessitant une trachéotomie en urgence, et une mort foetale in utero avec troubles de l'hémostase responsable du décès maternel dans un ...

  2. Hemangioma capilar de la parótida. Abordaje transoral

    OpenAIRE

    Sarra, Luis Domingo; Rodríguez, Juan Carlos; San Martino, Julio Alberto

    2014-01-01

    Los hemangiomas de la parótida son frecuentes en niños, representando aproximadamente el 50% de los tumores de dicha glándula durante el primer año de vida. Como contrapartida, estos tumores vasculares son extremadamente raros en pacientes adultos y solo se publican unos pocos casos aislados en la literatura, donde se mencionan las dificultades en el diagnóstico diferencial con los tumores primarios de las glándulas salivales. Presentamos un caso en una paciente adulta que consultó por una...

  3. Cartographie par carroyage et précision spatiale

    Directory of Open Access Journals (Sweden)

    Patrice LANGLOIS

    1998-03-01

    Full Text Available Dans le cadre d'une cartographie par carroyage, on étudie la désagrégation de variables zonales, en revenant sur l'hypothèse de l'équirépartition spatiale des populations. L'objectif est d'approcher des règles différenciées de désagrégation des variables en fusionnant des plans d'information de nature morphologique, topologique et environnementale.

  4. David Kasner, MD, and the Road to Pars Plana Vitrectomy

    Directory of Open Access Journals (Sweden)

    Christopher F. Blodi

    2016-01-01

    Full Text Available David Kasner, MD (1927–2001, used his extensive dissections of eye bank eyes and experiences in teaching cataract surgery to resident physicians to realize that excision of vitreous when present in the anterior chamber of eyes undergoing cataract surgery was preferable to prior intraoperative procedures. Noting that eyes tolerated his maneuvers, he then performed planned subtotal open-sky vitrectomies; first on a traumatized eye in 1961, then on two eyes of patients with amyloidosis (1966–1967. The success of these operations was noted by others, most particularly Robert Machemer, MD. Kasner's work directly led to further surgical developments, including closed pars plana vitrectomy.

  5. Predicting spectral and PAR light attenuation in Greenlandic coastal waters

    DEFF Research Database (Denmark)

    Murray, Ciarán; Markager, Stiig; Stedmon, Colin

    The spectral quality and penetration of light are key parameters controlling the productivity of Greenlandic fjords. Solar elevation and sea ice play an important role, but during the increasing ice free period and summer months in particular, light is also regulated by water constituents. We...... (CDOM), phytoplankton pigments and inorganic particles. These differences are due in part to hydrography and to the sources of meltwater: respectively, fjord-terminating and land-terminating glaciers. We present a model to explain the variation in spectral and PAR irradiance in terms of the variation...

  6. fortification des farines tropicales par l'introduction de proteines ...

    African Journals Online (AJOL)

    chiches, fève et haricot commun) est améliorée par l'extrusion. L'amidon de niébé extrudé à 180. °C possède une meilleure digestibilité que celui de niébé cru. CONCLUSION. Ce travail visait principalement la diversification des produits alimentaires à partir d'un mélange de farines de céréales locales, de légumineuses.

  7. Uveal neovascularization at the ora serrata and pars plana.

    Science.gov (United States)

    Kaba, F; el Baba, F; Green, W R

    1987-03-01

    Thirty-two eyes with uveal neovascularization at the ora serrata and pars plana were studied histopathologically. Chronic retinal detachment of various etiologies was the most frequently associated feature, present in 65% of the patients. In three eyes, the neovascularization took the form of an angiomatous lesion, whereas in the others, capillaries, arterioles, and venules were present. A history of glaucoma was found in 60% of the patients. Other associated findings included choroidal rupture, vitreous hemorrhage, and a history of cryotherapy. Uveal neovascularization at the ora serrata should be considered in the differential diagnosis of retinal angiomas, retinal telangiectasia, malignant melanoma, adult Coats's disease, peripheral proliferative retinopathies, and vitreous hemorrhage.

  8. Par-4-mediated recruitment of Amida to the actin cytoskeleton leads to the induction of apoptosis

    International Nuclear Information System (INIS)

    Boosen, Meike; Vetterkind, Susanne; Koplin, Ansgar; Illenberger, Susanne; Preuss, Ute

    2005-01-01

    Par-4 (prostate apoptosis response-4) sensitizes cells to apoptotic stimuli, but the exact mechanisms are still poorly understood. Using Par-4 as bait in a yeast two-hybrid screen, we identified Amida as a novel interaction partner, a ubiquitously expressed protein which has been suggested to be involved in apoptotic processes. Complex formation of Par-4 and Amida occurs in vitro and in vivo and is mediated via the C-termini of both proteins, involving the leucine zipper of Par-4. Amida resides mainly in the nucleus but displays nucleo-cytoplasmic shuttling in heterokaryons. Upon coexpression with Par-4 in REF52.2 cells, Amida translocates to the cytoplasm and is recruited to actin filaments by Par-4, resulting in enhanced induction of apoptosis. The synergistic effect of Amida/Par-4 complexes on the induction of apoptosis is abrogated when either Amida/Par-4 complex formation or association of these complexes with the actin cytoskeleton is impaired, indicating that the Par-4-mediated relocation of Amida to the actin cytoskeleton is crucial for the pro-apoptotic function of Par-4/Amida complexes in REF52.2 cells. The latter results in enhanced phosphorylation of the regulatory light chain of myosin II (MLC) as has previously been shown for Par-4-mediated recruitment of DAP-like kinase (Dlk), suggesting that the recruitment of nuclear proteins involved in the regulation of apoptotic processes to the actin filament system by Par-4 represents a potent mechanism how Par-4 can trigger apoptosis

  9. Decreased Expression of the Polarity Regulatory PAR Complex Predicts Poor Prognosis of the Patients with Colorectal Adenocarcinoma

    Directory of Open Access Journals (Sweden)

    Min-Kyung Yeo

    2018-02-01

    Full Text Available Partitioning defective (Par proteins regulate cell polarity and differentiation. Par3, Par6β, and protein kinase Cζ (PKCζ, which are PAR complex members, have been shown to be associated with oncogenesis and progression. Herein, we report the expression pattern and clinical relevance of Par3, Par6β, and PKCζ in colorectal adenocarcinoma (CRAC. A total of 393 primary CRACs, 41 primary-metastatic CRAC pairs, 41 adenomas with low-grade dysplasia, and 41 nontumor colorectal tissue samples were examined by immunohistochemistry and Western blot assays for Par3, Par6β, and PKCζ protein expressions. The association Par3, Par6β, and PKCζ expressions and clinicopathologic factors, including patient survival, was evaluated. Primary CRACs and adenomas demonstrated higher levels of Par3, Par6β, and PKCζ than in nontumor colorectal epithelia. The expressions of Par3, Par6β, and PKCζ were higher in primary CRACs as compared to adenomas or in metastatic CRACs. Among primary CRACs, decreased Par3 expression was found to correlate with a high proliferation rate and poor histologic differentiation, decreased PKCζ expression was correlated with pathologic TNM stage (I-II vs III-IV and lymph node metastasis, and decreased Par6β and PKCζ expressions were correlated with shortened overall survivals. In metastatic CRACs, decreased PKCζ expression was correlated with a shortened metastasis-free survival. While increased Par3, Par6β, and PKCζ expressions were implicated in tumorigenesis, decreased expressions of Par3, Par6β, and PKCζ were found to be associated with worse clinicopathologic factors in CRAC. In particular, the results of our study suggest that PKCζ down-expression is an independent poor prognostic and metastatic factor for CRAC.

  10. PhyloPars: estimation of missing parameter values using phylogeny.

    Science.gov (United States)

    Bruggeman, Jorn; Heringa, Jaap; Brandt, Bernd W

    2009-07-01

    A wealth of information on metabolic parameters of a species can be inferred from observations on species that are phylogenetically related. Phylogeny-based information can complement direct empirical evidence, and is particularly valuable if experiments on the species of interest are not feasible. The PhyloPars web server provides a statistically consistent method that combines an incomplete set of empirical observations with the species phylogeny to produce a complete set of parameter estimates for all species. It builds upon a state-of-the-art evolutionary model, extended with the ability to handle missing data. The resulting approach makes optimal use of all available information to produce estimates that can be an order of magnitude more accurate than ad-hoc alternatives. Uploading a phylogeny and incomplete feature matrix suffices to obtain estimates of all missing values, along with a measure of certainty. Real-time cross-validation provides further insight in the accuracy and bias expected for estimated values. The server allows for easy, efficient estimation of metabolic parameters, which can benefit a wide range of fields including systems biology and ecology. PhyloPars is available at: http://www.ibi.vu.nl/programs/phylopars/.

  11. Stress reactions involving the pars interarticularis in young athletes

    International Nuclear Information System (INIS)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    1981-01-01

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated

  12. Stress reactions involving the pars interarticularis in young athletes

    Energy Technology Data Exchange (ETDEWEB)

    Jackson, D.W.; Wiltse, L.L.; Dingeman, R.D.; Hayes, M.

    A stress reaction involving the pars interarticularis of the lumbar spine was confirmed in seven young athletes with a positive technetium pyrophosphate bone scan. No pars defects were detectable on their lumbosacral roentgenograms, which included oblique views. The return to normal levels of radioactive uptake on repeat bone scans correlated closely with their clinical course. If the bony reaction is recognized early, it may heal at a subroentgenographic level and prevent the development of lumbar spondylolysis. These early lesions usually show unilateral increased uptake at one lumbar level on the bone scan and, initially, the athlete localizes the pain to the corresponding unilateral lumbar paraspinous area. The ''one-legged hyperextension test'' is positive on the ipsilateral side and aggravates the pain. Treatment consists of avoiding the aggravating activities and resting. The average time for return to pain-free competition was 7.3 months. These developing defects may be the source of considerable prolonged disability in the young athlete, particularly if undiagnosed and untreated.

  13. Paracrine Apoptotic Effect of p53 Mediated by Tumor Suppressor Par-4

    Directory of Open Access Journals (Sweden)

    Ravshan Burikhanov

    2014-01-01

    Full Text Available The guardian of the genome, p53, is often mutated in cancer and may contribute to therapeutic resistance. Given that p53 is intact and functional in normal tissues, we harnessed its potential to inhibit the growth of p53-deficient cancer cells. Specific activation of p53 in normal fibroblasts selectively induced apoptosis in p53-deficient cancer cells. This paracrine effect was mediated by p53-dependent secretion of the tumor suppressor Par-4. Accordingly, the activation of p53 in normal mice, but not p53−/− or Par-4−/− mice, caused systemic elevation of Par-4, which induced apoptosis of p53-deficient tumor cells. Mechanistically, p53 induced Par-4 secretion by suppressing the expression of its binding partner, UACA, which sequesters Par-4. Thus, normal cells can be empowered by p53 activation to induce Par-4 secretion for the inhibition of therapy-resistant tumors.

  14. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Au Botswana, ce sont les jeunes femmes qui sont le plus touchées par les nouvelles infections par le VIH. Le présent projet a pour but de réduire le nombre de nouveaux cas d'infection par le VIH, en particulier chez les femmes de 15 à 29 ans. Bien que l'on recense des cas de VIH/sida dans la plupart des régions du ...

  15. Magnetic activity and radial velocity filtering of young Suns: the weak-line T-Tauri stars Par 1379 and Par 2244

    Science.gov (United States)

    Hill, C. A.; Carmona, A.; Donati, J.-F.; Hussain, G. A. J.; Gregory, S. G.; Alencar, S. H. P.; Bouvier, J.; The Matysse Collaboration

    2017-12-01

    We report the results of our spectropolarimetric monitoring of the weak-line T-Tauri stars (wTTSs) Par 1379 and Par 2244, within the MaTYSSE (Magnetic Topologies of Young Stars and the Survival of close-in giant Exoplanets) programme. Both stars are of a similar mass (1.6 and 1.8 M⊙) and age (1.8 and 1.1 Myr), with Par 1379 hosting an evolved low-mass dusty circumstellar disc, and with Par 2244 showing evidence of a young debris disc. We detect profile distortions and Zeeman signatures in the unpolarized and circularly polarized lines for each star, and have modelled their rotational modulation using tomographic imaging, yielding brightness and magnetic maps. We find that Par 1379 harbours a weak (250 G), mostly poloidal field tilted 65° from the rotation axis. In contrast, Par 2244 hosts a stronger field (860 G) split 3:2 between poloidal and toroidal components, with most of the energy in higher order modes, and with the poloidal component tilted 45° from the rotation axis. Compared to the lower mass wTTSs, V819 Tau and V830 Tau, Par 2244 has a similar field strength, but is much more complex, whereas the much less complex field of Par 1379 is also much weaker than any other mapped wTTS. We find moderate surface differential rotation of 1.4× and 1.8× smaller than Solar, for Par 1379 and Par 2244, respectively. Using our tomographic maps to predict the activity-related radial velocity (RV) jitter, and filter it from the RV curves, we find RV residuals with dispersions of 0.017 and 0.086 km s-1 for Par 1379 and Par 2244, respectively. We find no evidence for close-in giant planets around either star, with 3σ upper limits of 0.56 and 3.54 MJup (at an orbital distance of 0.1 au).

  16. Effect of a physical activity intervention on suPAR levels

    DEFF Research Database (Denmark)

    Rohde, Christopher; Polcwiartek, Christoffer; Andersen, Eivind

    2018-01-01

    OBJECTIVES: Soluble urokinase-type plasminogen activator receptor (suPAR) is a novel inflammatory marker, associated with lifestyle diseases and mortality risk. No studies have investigated whether physical activity may reduce suPAR levels using a randomized controlled design. DESIGN AND METHODS:.......219-0.215). Similar results were found for CRP levels. CONCLUSION: There was no change in suPAR levels after regular exercise compared to a control group implying that suPAR rather reflects underlying harmful inflammatory responses associated with disease development....

  17. IGF-II receptors in luminal and basolateral membranes isolated from pars convoluta and pars recta of rabbit proximal tubule

    DEFF Research Database (Denmark)

    Jacobsen, Christian; Jessen, H; Flyvbjerg, A

    1995-01-01

    The binding of 125I-labeled insulin-like growth factor-II (125I-IGF-II) to luminal and basolateral membrane vesicles isolated from pars convoluta and the straight part (pars recta) of rabbit proximal tubule was investigated. Analyses of the binding data by use of the general stoichiometric binding...... equation revealed, that in all preparations IGF-II was bound to one high-affinity binding site and other sites with lower affinities. The specificity of the high-affinity 125I-IGF-II binding to the membrane vesicles assessed by displacement by unlabeled IGF-II, IGF-I and insulin showed that IGF-I displaced...... 125I-IGF-II in the range 22.5-47.9 nM (IC50) whereas insulin did not effect 125I-IGF-II binding at all. beta-Galactosidase inhibited the 125I-IGF-II binding with half-maximal inhibition of 20-30 nM beta-galactosidase. D-Mannose 6-phosphate increased the binding of 125I-IGF-II and reversed...

  18. Patterns of axonal branching of neurons of the substantia nigra pars reticulata and pars lateralis in the rat.

    Science.gov (United States)

    Cebrián, Carolina; Parent, André; Prensa, Lucía

    2005-11-21

    Axons from neurons of the rat substantia nigra pars reticulata (SNr) and pars lateralis (SNl) were traced after injecting their cell body with biotinylated dextran amine. Thirty-two single axons were reconstructed from serial sagittal sections with a camera lucida, whereas four other SNr axons were reconstructed in the coronal plane to determine whether they innervate the contralateral hemisphere. Four distinct types of SNr projection neurons were identified based on their main axonal targets: type I neurons that project to the thalamus; type II neurons that target the thalamus, the superior colliculus (SC), and the pedunculopontine tegmental nucleus (PPTg); type III neurons that project to the periaqueductal gray matter and the thalamus; and type IV neurons that target the deep mesencephalic nucleus (DpMe) and the SC. The axons of the SNl showed the same branching patterns as SNr axons of types I, II, and IV. The coronal reconstructions demonstrated that SNr neurons innervate the thalamus, the SC, and the DpMe bilaterally. At the thalamic level, SNr and SNl axons targeted preferentially the ventral medial, ventral lateral, paracentral, parafascicular, and mediodorsal nuclei. Axons reaching the SC arborized selectively within the deep layers of this structure. Our results reveal that the SNr and SNl harbor several subtypes of projection neurons endowed with a highly patterned set of axon collaterals. This organization allows single neurons of these output structures of the basal ganglia to exert a multifaceted influence on a wide variety of diencephalic and midbrain structures. (c) 2005 Wiley-Liss, Inc.

  19. Un « gouvernement des journalistes par le Pouvoir politique » par défaut ?

    Directory of Open Access Journals (Sweden)

    Matthieu Lardeau

    2013-12-01

    Full Text Available Cet article présente les interactions de deux mouvements concomitants apparusprincipalement dans les décennies 1950 à 1970 dans le champ de la presse française : d’un côté les initiatives – consécutives à la démarche pionnière, en 1951, de création de la première Société des journalistes (SDJ au sein du Monde – menées par les journalistes de rédactions de quotidiens pour créer des SDJ dont la destination peut aller jusqu’à gouverner les journaux; de l’autre côté, les « réponses » apportées par les Pouvoirs politique et public pour contenir ces initiatives visant à étendre le pouvoir des journalistes dans la gestion et la gouvernance de leurs journaux. Cette étude exploratoire repose principalement sur l’analyse de deux types de littérature, souvent déconsidérés ou négligés par le champ académique, en dépit de leur grande richesse : (1 la littérature professionnelle, ayant pour principaux auteurs les journalistes et managers de presse (Périer Daville, Boegner, Pigasse, etc., florissante depuis 1944 et singulièrement durant les décennies 1960 et 1970 ; (2 la littérature grise constituée notamment par des rapports publics rédigés par des institutions comme les services du Premier ministre (commissions Lindon de 1970 et Serisé de 1972, le Conseil économique et social, etc. Nos principaux résultats montrent que les propositions ou actions menées par les journalistes (1 restent le plus souvent inexploitées in concreto par les journalistes eux-mêmes; (2 entrent le plus souvent en opposition avec les politiques de nouveaux actionnaires ou directions de journaux et avec les projets des autorités politiques et publiques qui cherchent à encadrer l’autonomie de la profession journalistique pour mieux gouverner celle-ci ; (3 combien in fine les représentants des différents acteurs impliqués s’accordent pour contenir l’émergence d’un « gouvernement des journalistes » par les

  20. Cancro em mogno africano no estado do Pará

    Directory of Open Access Journals (Sweden)

    Célia Regina Tremacoldi

    2013-06-01

    Full Text Available Sintomas de cancro foram observados em plantios de mogno africano, no município de Dom Eliseu, Pará. Os fungos associados aos tecidos sintomáticos foram identificados como Lasiodiplodia theobromae e Fusarium subglutinans. Culturas puras desses fungos foram testadas quanto à patogenicidade em mudas de mogno africano sadias. Apenas L. theobromae produziu cancro, por meio de inoculação por ferimento e alta umidade. A confirmação de L. theobromae como agente causal do cancro ocorreu após o reisolamento do fungo a partir das plantas inoculadas em casa de vegetação, concluindo a primeira verificação do postulado de Koch para esse patossistema.

  1. Hemangioma capilar de la parótida. Abordaje transoral

    Directory of Open Access Journals (Sweden)

    Luis Domingo Sarra

    2014-10-01

    Presentamos un caso en una paciente adulta que consultó por una masa en la región parotídea y parálisis facial periférica con el mayor componente tumoral que se manifestaba en la cavidad oral. La ecografía mostró una masa sólida. La punción aspiración con aguja fina fue negativa con material hemático en 2 oportunidades. No tuvimos sospecha de la presencia de un tumor de origen vascular, por lo que no fue solicitada una RMN. El caso fue resuelto a través de un abordaje quirúrgico poco utilizado, tras obtener una biopsia por congelación negativa.

  2. Parálisis cerebral. Tratamiento ortopodológico

    OpenAIRE

    Querol Martínez, Esther; Crespo Martínez, Artur; Concustell Gonfaus, Josep; Sacristán Valero, Sergi; Concustell Fargas, Olga; Carrera Casanova, Ana

    2005-01-01

    Después de varios años de experiencia en la aplicación de las férulas estabilizadoras del sistema aquileocalcáneo plantar FESAP) en pacientes con parálisis cerebral, creemos que deberían ser el tratamiento ortopodológico de elección del pie equino en niños con miopatías y lesiones neurológlcas de la unidad motora, del sistema piramidal o extrapiramidal, tanto por su perfecta adaptación a la morfología de la extremidad inferior como por sus caracteristicas funcionales y sus acciones fisio1ógic...

  3. Myopathy in horses with pituitary pars intermedia dysfunction (Cushing's disease).

    Science.gov (United States)

    Aleman, M; Watson, J L; Williams, D C; LeCouteur, R A; Nieto, J E; Shelton, G D

    2006-11-01

    Fifteen horses with pituitary pars intermedia dysfunction were studied. The horses were of various breeds and between 15 and 28 years of age. Control horses matched for breed and age were studied for comparison. Evaluations included complete blood cell count and serum biochemical analysis, electromyography, and gluteus medius muscle biopsies for histochemical, morphometric, and ultrastructural analysis. No differences were found between groups of horses on routine laboratory analysis or electromyography. We demonstrated that muscle wasting in diseased horses was the result of atrophy of types 2A and 2B muscle fibers and loss of type 2B myofibers. Mild non-specific non-inflammatory myopathic alterations such as myofiber size variation, internal nuclei, perimysial, endomysial and sarcoplasmic fat accumulation were observed. At the ultrastructural level, subsarcolemmal mitochondrial accumulation and increased lipid droplets were evident. Similar to other species, this study confirmed atrophy of type 2 fibers as the cause of muscle mass loss in horses with Cushing's disease.

  4. IMPROVEMENT OF PRODUCTION PLANNING IN COMPANY PARS KOMPONENTY

    Directory of Open Access Journals (Sweden)

    René Klega

    2014-03-01

    Full Text Available The article analyzes the current status of production planning in company Pars Komponenty s.r.o., proposes a new method of planning based on application of the principle of MRP. It is a discrete type of production with high complexity of BOM and MTO (Make-to-Order and ETO (Engineering-to-Order from the point of decoupling point. The original planning system plans according to production capacity backward without collisions, but for a given type of production does not work in practice. Planning system was analyzed and the main problems were identified, which were high work in progress and material stocks. This article target is to propose a new planining system based on the inclusion of time reserves of purchased material items. New planning system was tested in practise with benefit in reducing both the material inventory and work in progress.

  5. Paternal age related schizophrenia (PARS): Latent subgroups detected by k-means clustering analysis.

    Science.gov (United States)

    Lee, Hyejoo; Malaspina, Dolores; Ahn, Hongshik; Perrin, Mary; Opler, Mark G; Kleinhaus, Karine; Harlap, Susan; Goetz, Raymond; Antonius, Daniel

    2011-05-01

    Paternal age related schizophrenia (PARS) has been proposed as a subgroup of schizophrenia with distinct etiology, pathophysiology and symptoms. This study uses a k-means clustering analysis approach to generate hypotheses about differences between PARS and other cases of schizophrenia. We studied PARS (operationally defined as not having any family history of schizophrenia among first and second-degree relatives and fathers' age at birth ≥ 35 years) in a series of schizophrenia cases recruited from a research unit. Data were available on demographic variables, symptoms (Positive and Negative Syndrome Scale; PANSS), cognitive tests (Wechsler Adult Intelligence Scale-Revised; WAIS-R) and olfaction (University of Pennsylvania Smell Identification Test; UPSIT). We conducted a series of k-means clustering analyses to identify clusters of cases containing high concentrations of PARS. Two analyses generated clusters with high concentrations of PARS cases. The first analysis (N=136; PARS=34) revealed a cluster containing 83% PARS cases, in which the patients showed a significant discrepancy between verbal and performance intelligence. The mean paternal and maternal ages were 41 and 33, respectively. The second analysis (N=123; PARS=30) revealed a cluster containing 71% PARS cases, of which 93% were females; the mean age of onset of psychosis, at 17.2, was significantly early. These results strengthen the evidence that PARS cases differ from other patients with schizophrenia. Hypothesis-generating findings suggest that features of PARS may include a discrepancy between verbal and performance intelligence, and in females, an early age of onset. These findings provide a rationale for separating these phenotypes from others in future clinical, genetic and pathophysiologic studies of schizophrenia and in considering responses to treatment. Copyright © 2011 Elsevier B.V. All rights reserved.

  6. Determination of tritium by counting; Dosage du tritium par comptage

    Energy Technology Data Exchange (ETDEWEB)

    Schott, R.; Froment, G.; Pinson, J.; Genty, C. [Commissariat a l' Energie Atomique, Bruyeres-le-Chatel (France). Centre d' Etudes

    1968-07-01

    Ionisation chamber assay of tritium in any gaseous mixture is a simple, fast and accurate method. We used the method of relative determination by comparison to a standard rather than the method of absolute assay in which case the constants are known with too little accuracy. The efficiency of the chamber was studied in connection to the pressure inside the chamber and its total volume. The calibration is linear in the range we are taking into account (1 to 80 millicuries). The reproducibility of the method is good: 13 runs gave a coefficient of variation of 1.6 per cent. The relative accuracy was found equal to {+-} 1.3 per cent. To end the paper, we describe in detail the apparatus and the ways of proceedings. (authors) [French] Le comptage du tritium par chambre d'ionisation est une methode simple, rapide et precise pour determiner la teneur en tritium d'un melange gazeux quelconque. Nous avons prefere utiliser la methode de determination relative par rapport a un etalon car, dans le cas d'une determination absolue, les constantes sont connues avec une trop grande incertitude. L'efficacite de la chambre a ete etudiee en fonction de la variation de la pression d'argon a l'interieur de la chambre et du volume total, de cette derniere. L'etalonnage s'est revele lineaire dans le domaine de mesures qui nous interessaient (1 a 80 millicuries). La reproductibillte de la methode est tres bonne, le coefficient de variation pour une serie de 13 essais etant de 1,6 pour cent, quant a la precision relative, elle a ete evaluee a {+-} 1,3 pour cent. Pour terminer, nous donnons une description detaillee de l'appareillage utilise et du mode operatoire suivi. (auteurs)

  7. Clinical outcomes of pars plicata anterior vitrectomy: 2-year results

    Directory of Open Access Journals (Sweden)

    Priya Narang

    2015-01-01

    Full Text Available Purpose: To demonstrate the safety and outcome of a surgical approach that uses pars plicata site for anterior vitrectomy during phacoemulsification procedure complicated by posterior capsule rupture and residual cortical matter. Design: Single center, retrospective, interventional, noncomparative study. Materials and Methods: Medical records of a consecutive series of 35 eyes of 35 patients who underwent pars plicata anterior vitrectomy (PPAV were reviewed. The main outcome measures were corrected and uncorrected distance visual acuity (CDVA, UDVA, early and late postoperative complications and intraocular pressure (IOP. Ultrasound biomicroscopic (UBM evaluation of sclerotomy site and spectral domain optical coherence tomography analysis for central macular thickness (CMT was performed. The final visual outcome at 2 years was evaluated. Results: At 2 years follow-up, the mean postoperative UDVA (logarithm of the minimum angle of resolution [logMAR] and CDVA (logMAR was 0.49 ± 0.26 and 0.19 ± 0.14, respectively. There was no significant change in the IOP (P = 0.061 and the mean CMT at 2 years was 192.5 ± 5.54 mm. The postoperative UBM image of the sclerotomy site at 8 weeks demonstrated a clear wound without any vitreous adhesion or incarceration. Intraoperative hyphema was seen in 1 (2.8% case and postoperative uveitis was seen in 2 (5.7% cases, which resolved with medications. No case of an iatrogenic retinal break or retinal detachment was reported. Conclusions: PPAV enables a closed chamber approach, allows thorough cleanup of vitreous in the pupillary plane and anterior chamber and affords better access to the subincisional and retropupillary cortical remnant with a significant visual outcome and an acceptable complication rate.

  8. [The course of zonular fibers in the area of pars plicata corporis cilaris pars plana, ora serrata and retina. Eectron microsocpic study].

    Science.gov (United States)

    Roll, P; Reich, M E; Hofmann, H

    1975-01-01

    The course of zonular fibers in the area of pars plicata corporis ciliaris could be shown down to the pigmented epithelial layer and its basement membrane. S ingle fibrils enter in a connection with the plasma membrane in allinvestigated parts. Fibrils could be observed in the cytoplasm of the ora serrata. For the other areas (pars plicata corporis ciliaris, parsplana) this can be suggested too.

  9. Effect of pre-drying and par-frying conditions on the crispness of French fries

    NARCIS (Netherlands)

    Loon, W.A.M.; Visser, J.E.; Linssen, J.P.H.; Somsen, D.J.; Klok, H.J.; Voragen, A.G.J.

    2007-01-01

    An experimental design was used to study the effect of pre-drying (to 10, 15 and 20% weight loss) and par-frying conditions (160, 170 and 180 °C) on the crispness of French fries. Par-frying time was adjusted with a software program to obtain equal moisture content and internal texture for all

  10. Human bronchial epithelial cells express PAR-2 with different sensitivity to thermolysin.

    Science.gov (United States)

    Ubl, Joachim J; Grishina, Zoryana V; Sukhomlin, Tatiana K; Welte, Tobias; Sedehizade, Fariba; Reiser, Georg

    2002-06-01

    Protease-activated receptor-2 (PAR-2) plays a role in inflammatory reactions in airway physiology. Proteases cleaving the extracellular NH(2) terminus of receptors activate or inactivate PAR, thus possessing a therapeutic potential. Using RT-PCR and immunocytochemistry, we show PAR-2 in human airway epithelial cell lines human bronchial epithelial (HBE) and A549. Functional expression of PAR-2 was confirmed by Ca(2+) imaging studies using the receptor agonist protease trypsin. The effect was abolished by soybean trypsin inhibitor and mimicked by the specific PAR-2 peptide agonist SLIGKV. Amplitude and duration of PAR-2-elicited Ca(2+) response in HBE and A549 cells depend on concentration and time of agonist superfusion. The response is partially pertussis toxin (PTX) insensitive, abolished by the phospholipase C inhibitor U-73122, and diminished by the inositol 1,4,5-trisphosphate receptor antagonist 2-aminoethoxydiphenyl borate. Cathepsin G altered neither the resting Ca(2+) level nor PAR-2-elicited Ca(2+) response. Thermolysin, a prototypic bacterial metalloprotease, induced a dose-dependent Ca(2+) response in HBE, but not A549, cells. In both cell lines, thermolysin abolished the response to a subsequent trypsin challenge but not to SLIGKV. Thus different epithelial cell types express different PAR-2 with identical responses to physiological stimuli (trypsin, SLIGKV) but different sensitivity to modifying proteases, such as thermolysin.

  11. Urokinase-type plasminogen activator receptor (uPAR) as a promising new imaging target

    DEFF Research Database (Denmark)

    Persson, Morten; Kjaer, Andreas

    2013-01-01

    modalities such as optical imaging, magnetic resonance imaging, single photon emission computer tomography (SPECT) and positron emission topography (PET). In this review, we will discuss recent advances in the development of uPAR-targeted imaging ligands according to imaging modality. In addition, we...... will discuss the potential future clinical application for uPAR imaging as a new imaging biomarker....

  12. PET imaging of urokinase-type plasminogen activator receptor (uPAR) in prostate cancer

    DEFF Research Database (Denmark)

    Skovgaard, Dorthe; Persson, Morten; Kjaer, Andreas

    2016-01-01

    , which can provide the required quantitative information on the uPAR expression profile, without the need for invasive procedures and the risk of missing the target due to tumor heterogeneity. These observations support non-invasive PET imaging of uPAR in PC as a clinically relevant diagnostic...

  13. Réduction du risque d'infection par le VIH au Botswana - essais ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    sida qui ont entraîné une diminution des taux d'infection par le VIH, ... Le projet sera piloté par le CIET Trust et la National AIDS Coordinating Agency, qui travailleront en étroite collaboration avec le ministère de la Santé et le ministère des ...

  14. Effect of Par Frying on Composition and Texture of Breaded and Battered Catfish

    Science.gov (United States)

    Catfish is often consumed as a breaded and battered fried product; however, baking is considered a healthier alternative to frying. One method of improving the texture properties of baked products is to par fried prior to baking. The objective of this study was to examine the effect of par frying ...

  15. Solar PAR and UVR modify the community composition and photosynthetic activity of sea ice algae.

    Science.gov (United States)

    Enberg, Sara; Piiparinen, Jonna; Majaneva, Markus; Vähätalo, Anssi V; Autio, Riitta; Rintala, Janne-Markus

    2015-10-01

    The effects of increased photosynthetically active radiation (PAR) and ultraviolet radiation (UVR) on species diversity, biomass and photosynthetic activity were studied in fast ice algal communities. The experimental set-up consisted of nine 1.44 m(2) squares with three treatments: untreated with natural snow cover (UNT), snow-free (PAR + UVR) and snow-free ice covered with a UV screen (PAR). The total algal biomass, dominated by diatoms and dinoflagellates, increased in all treatments during the experiment. However, the smaller biomass growth in the top 10-cm layer of the PAR + UVR treatment compared with the PAR treatment indicated the negative effect of UVR. Scrippsiella complex (mainly Scrippsiella hangoei, Biecheleria baltica and Gymnodinium corollarium) showed UV sensitivity in the top 5-cm layer, whereas Heterocapsa arctica ssp. frigida and green algae showed sensitivity to both PAR and UVR. The photosynthetic activity was highest in the top 5-cm layer of the PAR treatment, where the biomass of the pennate diatom Nitzschia frigida increased, indicating the UV sensitivity of this species. This study shows that UVR is one of the controlling factors of algal communities in Baltic Sea ice, and that increased availability of PAR together with UVR exclusion can cause changes in algal biomass, photosynthetic activity and community composition. © FEMS 2015. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  16. Spectral variations of UV-A and PAR solar radiation in estuarine waters of Goa

    Digital Repository Service at National Institute of Oceanography (India)

    Talaulikar, M.; Suresh, T.; Silveira, N.; Desa, E.; Matondkar, S.G.P.; Lotlikar, A.

    radiation (400 to 700 nm), PAR and ultraviolet radiation in the range 350-400 nm (UV-A) are presented here. The mean PAR values at the surface were 327 W/m sup(2) and reduced to 84 W/m sup(2) at first optical depth, Z sub(90) (m) in water. The first optical...

  17. Participatory Action Research (PAR) cum Action Research (AR) in Teacher Professional Development: A Literature Review

    Science.gov (United States)

    Morales, Marie Paz E.

    2016-01-01

    This paper reviews Participatory Action Research as an approach to teacher professional development. It maps the origins of Participatory Action Research (PAR) and discusses the benefits and challenges that have been identified by other researchers in utilizing PAR approaches in conducting research. It draws ideas of combining the features of…

  18. A Bipolar Spindle of Antiparallel ParM Filaments Drives Bacterial Plasmid Segregation

    DEFF Research Database (Denmark)

    Gayathri, P; Fujii, T; Møller-Jensen, Jakob

    2012-01-01

    To ensure their stable inheritance by daughter cells during cell division, bacterial low copy-number plasmids make simple DNA segregating machines that use an elongating protein filament between sister plasmids. In the ParMRC system of Escherichia coli R1 plasmid, ParM, an actin-like protein, forms...

  19. Narrative Identities and the Plebiscite in Pará: An Analysis of the Front Pages for O Liberal and Diário do Pará

    Directory of Open Access Journals (Sweden)

    Alda Cristina Silva da Costa

    2017-05-01

    Full Text Available On December 11, 2011, a plebiscite was held in Pará proposing to create two separatist states, Carajás and Tapajós, out of the state of Pará. The public voted against both projects. This article analyzes the narrative identities found on the front pages of O Liberal and Diário do Pará newspapers about the plebiscite in Pará. Depth Hermeneutics (DH, as proposed by Thompson (2011, was used as the methodological reference. DH emphasizes the object of analysis as a meaningful symbolic construction requiring interpretation. Narrative analysis, as proposed by Motta (2007, was the main research technique used to highlight the movement of construction of journalistic (discursive characters. The narrative identities built by the two newspapers showed that both were against the creation of the new states, but for very different reasons. The flag of Pará was the main object used to induce the idea of unity. Em 11 de dezembro de 2011, o plebiscito no Pará propôs a criação dos estados de Carajás e de Tapajós a partir da divisão do estado do Pará. O resultado da consulta pública foi negativo aos dois projetos. O artigo analisa as identidades narrativas constituídas pelas primeiras páginas dos jornais O Liberal e Diário do Pará sobre o plebiscito no Pará. Utilizou-se como referencial metodológico a Hermenêutica em Profundidade (HP, proposta por Thompson (2011. A HP evidencia o fato de que o objeto de análise é uma construção simbólica significativa, que exige uma interpretação. Como principal técnica de pesquisa, a análise narrativa, proposta por Motta (2007, com ênfase no movimento de construção de personagens jornalísticas (discursivas. As identidades narrativas construídas pelos dois jornais indicaram que ambos eram contrários à criação dos novos estados, porém por motivos divergentes. A bandeira do Pará foi o principal elemento utilizado para evocar a ideia de unidade. En 11 de diciembre de 2011, el plebiscito en

  20. Effect of simvastatin and ezetimibe on suPAR levels and outcomes

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Forman, Julie L

    2018-01-01

    -lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using...... and Ezetimibe treatment impeded the progression of the time-related increase in plasma suPAR levels. Year-1 suPAR was associated with all-cause mortality, MCE, and AVE irrespective of baseline levels (SEAS study: NCT00092677)....... cardiovascular events (MCE) composed of ischemic cardiovascular events (ICE) and aortic valve related events (AVE). RESULTS: After 4.3 years of follow-up, suPAR levels had increased by 9.2% (95% confidence interval [CI]: 7.0%-11.5%) in the placebo group, but only by 4.1% (1.9%-6.2%) in the group with lipid...

  1. par genes in Mycobacterium bovis and Mycobacterium smegmatis are arranged in an operon transcribed from "SigGC" promoters

    Directory of Open Access Journals (Sweden)

    Casart Yveth

    2008-03-01

    Full Text Available Abstract Background The ParA/Soj and ParB/Spo0J proteins, and the cis-acting parS site, participate actively in chromosome segregation and cell cycle progression. Genes homologous to parA and parB, and two putative parS copies, have been identified in the Mycobacterium bovis BCG and Mycobacterium smegmatis chromosomes. As in Mycobacterium tuberculosis, the parA and parB genes in these two non-pathogenic mycobacteria are located near the chromosomal origin of replication. The present work focused on the determination of the transcriptional organisation of the ~6 Kb orf60K-parB region of M. bovis BCG and M. smegmatis by primer extension, transcriptional fusions to the green fluorescence protein (GFP and quantitative RT-PCR. Results The parAB genes were arranged in an operon. However, we also found promoters upstream of each one of these genes. Seven putative promoter sequences were identified in the orf60K-parB region of M. bovis BCG, whilst four were identified in the homologous region of M. smegmatis, one upstream of each open reading frame (ORF. Real-time PCR assays showed that in M. smegmatis, mRNA-parA and mRNA-parB levels decreased between the exponential and stationary phases. In M. bovis BCG, mRNA-parA levels also decreased between the exponential and stationary phases. However, parB expression was higher than parA expression and remained almost unchanged along the growth curve. Conclusion The majority of the proposed promoter regions had features characteristic of Mycobacterium promoters previously denoted as Group D. The -10 hexamer of a strong E. coli σ70-like promoter, located upstream of gidB of M. bovis BCG, overlapped with a putative parS sequence, suggesting that the transcription from this promoter might be regulated by the binding of ParB to parS.

  2. Facteurs de risque de mortalité par tuberculose pulmonaire

    Science.gov (United States)

    Janah, Hicham; Souhi, Hicham; Kouismi, Hatim; Mark, Karima; Zahraoui, Rachida; Benamor, Jouda; Soualhi, Mona; Bourkadi, Jamal Eddine

    2014-01-01

    La tuberculose est une maladie infectieuse transmissible provoquée par myco-bacterium tuberculosis (bacille de Koch ou BK). Elle représente, selon les estimations del'Organisation Mondiale de la Santé (OMS), l'une des pathologies infectieuses causant le plus de décès au niveau mondial avec plus de 1 million de décès par an. Pour déterminer les facteurs de risque de mortalité au cours de la tuberculose pulmonaire à microscopie positive nous avons mené une étude rétrospective portant sur tous les cas de tuberculose pulmonaire à microscopie positive et qui étaient décédés au cours de leur hospitalisation. Cette étude a colligé 1803 cas de tuberculose sur une période de 2 ans et demi dont 46 sont décédés. La prévalence de décès est de 2,55%. La population se répartit en 32 hommes et 14 femmes. L’âge moyen était de 53ans ± 17 ans. Le tabagisme était retrouvé chez la moitié des cas. Une comorbidité était retrouvée dans 43%, avec 17% de diabète. Le délai de diagnostic avait une médiane de 60 jours avec percentile (30j; 105j). La symptomatologie clinique était dominée par la toux, la dyspnée et les expectorations soit respectivement: 97,8%, 69,6% et 67,4% des cas. Sur le plan radiologique les lésions étaient diffuses et bilatérales dans 76,1% des cas. Tous les patients étaient mis sous SRHZ. 11% avaient présenté une toxicité aux antibacillaires (de type hépatiques dans 3 cas et neurologiques dans 2 cas). Le délai médian de décès était de 8,5 jours (5j; 17j). Les causes de décès retrouvées étaient: Une hépatite fulminante (3 cas), une décompensation acido-cétosique (3 cas), un SDRA (2 cas), des hémoptysies foudroyantes (2 cas), et respectivement un cas secondaire à une décompensation de BPCO, une décompensation cardiaque, une hypoglycémie et un tableau d'anasarque. Cette étude suggère que le terrain, le retard diagnostique et les effets secondaires du traitement sont les principaux facteurs de risque de

  3. Efectos de la desnutrición sobre la colagenización de anastomosis intestinales: análisis de procolágeno y telopéptido carboxiterminal mediante radioinmunoanálisis Role of malnutrition in intestinal anastomosis collagenization: an analysis of procollagen (PINP and carboxyterminal telopeptide (ICTP by radioimmunoassay

    Directory of Open Access Journals (Sweden)

    J. M. Álamo

    2007-02-01

    Full Text Available Introducción: diversos factores influyen en la cicatrización correcta de las suturas intestinales tras la práctica de una resección intestinal. Uno de los factores más implicados es el estado nutricional del paciente. Objetivos: evaluar la influencia de la desnutrición inducida sobre la viabilidad de una anastomosis intestinal primaria mediante el análisis del procolágeno (PINP como marcador de la síntesis de colágeno I, y del telopéptido carboxiterminal del colágeno I (ICTP como marcador de la destrucción del mismo. Métodos: 40 ratas Wistar y material de radioinmunoensayo. Métodos: diseñamos 2 grupos de ratas, 20 animales por cada grupo: grupo control (A y grupo "desnutrición" (B. Se analiza PINP e ICTP mediante RIA sobre tejido colónico homogeneizado, preanastomótico y anastomótico. Resultados: existen unos niveles menores de PINP en el colon de las ratas del grupo B comparado con el colon del grupo A (0,3620 y 0,4340 µg/g respectivamente (p = 0,032. Hay un mayor nivel de ICTP analizado en el colon del grupo B (0,9545 en contraposición a 0,8460 µg/g en el grupo A (p = 0,875. En las anastomosis del grupo B existe una menor síntesis de PINP en comparación con el grupo A (0,376 y 0,468 µg/g respectivamente, p = 0,002. Conclusiones: la anastomosis colónica incrementa los niveles de PINP e ICTP en el tejido cicatricial (p = 0,000; la malnutrición reduce la colagenización de las anastomosis (p = 0,000.Introduction: some clinical, anatomo-pathological, and technical factors influence the correct healing of intestinal suture following an intestinal resection. One of the most influential factors is patient nutritional status. Objectives: to evaluate the influence of malnutrition on the viability of primary intestinal anastomosis by the analysis of collagen I deposition. Methods: 40 Wistar rats, radioimmunoassay material. We used 2 groups of rats, 20 animals in each group: a control group (A and a "malnutrition" group (B

  4. Urine suPAR levels compared with plasma suPAR levels as predictors of post-consultation mortality risk among individuals assumed to be TB-negative: a prospective cohort study

    DEFF Research Database (Denmark)

    Rabna, Paulo; Andersen, Andreas; Wejse, Christian

    2010-01-01

    -suPAR was measured using a commercial ELISA (suPARnostic®). We found that U-suPAR carried significant prognostic information on mortality for HIV-infected subjects with an area under the ROC curve of 0.75. For HIV-negative individuals, little or no prognostic effect was observed. However, in both HIV positives...... and negatives, the predictive effect of U-suPAR was found to be inferior to that of P-suPAR....

  5. Evaluation des bassins par modélisation intégrée en deux dimensions des transferts techniques, de l'écoulement des fluides, de la genèse et de la migration des hydrocarbures Basin Evaluation by Integrated Two-Dimensional Modeling of Heat Transfer, Fluid Flow, Hydrocarbon Generation, and Migration

    Directory of Open Access Journals (Sweden)

    Chenet P. Y.

    2006-11-01

    Full Text Available Le modèle de bassin exposé dans cet article décrit les phénomènes physiques et chimiques qui contrôlent la formation d'accumulations commerciales, dans le cadre évolutif d'un bassin sédimentaire affecté par la subsidence : transfert de chaleur, compaction et écoulement de l'eau, génèse des hydrocarbures, migration diphasique de l'eau et des hydrocarbures. Le modèle tient compte des variations de conductivité et des phénomènes thermiques transitoires pour reconstituer les paléo-températures. Des validations quantitatives de la reconstitution des paléo-températures et du modèle cinétique de formation des hydrocarbures peuvent être obtenues par comparaison avec les températures actuelles et les données géochimiques. Les écoulements et les surpressions induits par la compaction sont décrits en couplant une loi de compaction avec la loi de Darcy, classique pour les écoulements de l'eau, en ajoutant un critère de fracturation hydraulique naturelle. Ceci permet de modéliser les pressions anormales dans des séquences deltaïques récentes (delta de la Mahakam, comme dans des bassins liés à des rifts anciens (mer du Nord. Une adaptation de la loi de Darcy aux écoulements diphasiques permet de reproduire la migration primaire et la migration secondaire. En particulier, le modèle permet d'étudier le rôle des pressions anormales et l'influence des failles sur la migration et le piégeage. Nos résultats confirment que les modèles de bassins peuvent contribuer à synthétiser les données géologiques, géophysiques et géochimiques dans un schéma cohérent. En précisant l'évaluation pétrolière, ces modèles constituent une des principales voies pour améliorer l'efficacité de l'exploration. The basin model discussed in this paper describes the physical and chemical phenomena that control the formation of commercial accumulations of hydrocarbons in the moving framework of a subsiding sedimentary basin : heat

  6. La limitation de l’ontologie par la logique

    Directory of Open Access Journals (Sweden)

    John J. Drummond

    2009-02-01

    Full Text Available Cet article maintient que l’intérêt de Husserl pour le développement d’une logique pure en tant que théorie de la science limite sa conception de l’ontologie. L’ontologie formelle est, pour Husserl, une théorie formelle des objets de connaissance, dont les catégories fondamentales sont celles de substance, propriété et relation. En outre, les ontologies régionales évoluent au sein des limites catégorielles définies par l’ontologie formelle. Mais une telle ontologie laisse de côté les activités et les processus de tout genre, parmi lesquels le plus important est celui de l’ « avoir à l’esprit ». La phénoménologie transcendantale, en revanche, s’occupe de l’être-conscient-du-monde, un être-conscient qui est cependant inséparable de l’être-dans-le-monde. Cette phénoménologie se situe sur le même terrain ontologique que l’ontologie fondamentale de Heidegger. Mais alors, bien que la notion husserlienne d’ontologie soit limitée par le rôle dominant attribué à la logique en tant que théorie de la science et à la connaissance vraie qui lui est propre, il y a plus d’ontologie chez Husserl que dans son « ontologie ».This paper argues that Husserl’s concern with the development of pure logic as a theory of science limits his conception of ontology. Formal ontology is, for Husserl, a formal theory of the objects of cognition, and its fundamental categories are substantiality, property, and relation. Moreover, regional ontologies work within the categorial boundaries defined by formal ontology. Lost from view in this ontology are activities and processes of various kinds, of which “minding” is the most significant. Husserl’s transcendental phenomenology is an account of being-conscious-of-the-world, a being-conscious, however, that is inseparable from being-in-a-world.  This phenomenology is aimed at the same ontological terrain as Heidegger’s fundamental ontology. Hence, while

  7. Evaluation de la qualite osseuse par les ondes guidees ultrasonores =

    Science.gov (United States)

    Abid, Alexandre

    La caracterisation des proprietes mecaniques de l'os cortical est un domaine d'interet pour la recherche orthopedique. En effet, cette caracterisation peut apporter des informations primordiales pour determiner le risque de fracture, la presence de microfractures ou encore depister l'osteoporose. Les deux principales techniques actuelles de caracterisation de ces proprietes sont le Dual-energy X-ray Absorptiometry (DXA) et le Quantitative Computed Tomogaphy (QCT). Ces techniques ne sont pas optimales et presentent certaines limites, ainsi l'efficacite du DXA est questionnee dans le milieu orthopedique tandis que le QCT necessite des niveaux de radiations problematiques pour en faire un outil de depistage. Les ondes guidees ultrasonores sont utilisees depuis de nombreuses annees pour detecter les fissures, la geometrie et les proprietes mecaniques de cylindres, tuyaux et autres structures dans des milieux industriels. De plus, leur utilisation est plus abordable que celle du DXA et n'engendrent pas de radiation ce qui les rendent prometteuses pour detecter les proprietes mecaniques des os. Depuis moins de dix ans, de nombreux laboratoires de recherche tentent de transposer ces techniques au monde medical, en propageant les ondes guidees ultrasonores dans les os. Le travail presente ici a pour but de demontrer le potentiel des ondes guidees ultrasonores pour determiner l'evolution des proprietes mecaniques de l'os cortical. Il commence par une introduction generale sur les ondes guidees ultrasonores et une revue de la litterature des differentes techniques relatives a l'utilisation des ondes guidees ultrasonores sur les os. L'article redige lors de ma maitrise est ensuite presente. L'objectif de cet article est d'exciter et de detecter certains modes des ondes guides presentant une sensibilite a la deterioration des proprietes mecaniques de l'os cortical. Ce travail est realise en modelisant par elements finis la propagation de ces ondes dans deux modeles osseux

  8. Profiling gene expression induced by protease-activated receptor 2 (PAR2 activation in human kidney cells.

    Directory of Open Access Journals (Sweden)

    Jacky Y Suen

    Full Text Available Protease-Activated Receptor-2 (PAR2 has been implicated through genetic knockout mice with cytokine regulation and arthritis development. Many studies have associated PAR2 with inflammatory conditions (arthritis, airways inflammation, IBD and key events in tumor progression (angiogenesis, metastasis, but they have relied heavily on the use of single agonists to identify physiological roles for PAR2. However such probes are now known not to be highly selective for PAR2, and thus precisely what PAR2 does and what mechanisms of downstream regulation are truly affected remain obscure. Effects of PAR2 activation on gene expression in Human Embryonic Kidney cells (HEK293, a commonly studied cell line in PAR2 research, were investigated here by comparing 19,000 human genes for intersecting up- or down-regulation by both trypsin (an endogenous protease that activates PAR2 and a PAR2 activating hexapeptide (2f-LIGRLO-NH(2. Among 2,500 human genes regulated similarly by both agonists, there were clear associations between PAR2 activation and cellular metabolism (1,000 genes, the cell cycle, the MAPK pathway, HDAC and sirtuin enzymes, inflammatory cytokines, and anti-complement function. PAR-2 activation up-regulated four genes more than 5 fold (DUSP6, WWOX, AREG, SERPINB2 and down-regulated another six genes more than 3 fold (TXNIP, RARG, ITGB4, CTSD, MSC and TM4SF15. Both PAR2 and PAR1 activation resulted in up-regulated expression of several genes (CD44, FOSL1, TNFRSF12A, RAB3A, COPEB, CORO1C, THBS1, SDC4 known to be important in cancer. This is the first widespread profiling of specific activation of PAR2 and provides a valuable platform for better understanding key mechanistic roles of PAR2 in human physiology. Results clearly support the development of both antagonists and agonists of human PAR2 as potential disease modifying therapeutic agents.

  9. Envenimation mortelle par morsure de serpent chez une femme enceinte

    Directory of Open Access Journals (Sweden)

    Abdelkarim Shimi

    2011-02-01

    Full Text Available En Afrique, la prise en charge des envenimations vipérines demeure un problème majeur de santé publique avec un taux de mortalité qui reste élevé.La survenue d’une envenimation vipérine au cours de la grossesse est un événement rare, et grave du fait des conséquences maternelles et fatales qui en découlent. Les auteurs rapportent un cas de morsure de serpent au niveau de la face chez une femme enceinte, dont l’évolution a été marquée par l’installation d’un œdème cervico-facial nécessitant une trachéotomie en urgence, et une mort fatale in utero avec troubles de l’hémostase responsable du décès maternel dans un tableau de choc hémorragique.

  10. Lamellar pathology in horses with pituitary pars intermedia dysfunction.

    Science.gov (United States)

    Karikoski, N P; Patterson-Kane, J C; Singer, E R; McFarlane, D; McGowan, C M

    2016-07-01

    Hoof lamellar pathology in horses with pituitary pars intermedia dysfunction (PPID) has not been described previously. To describe the histomorphometry and pathological lesions in hoof lamellar tissue of animals that had PPID with or without concurrent laminitis, with reference to age-matched controls. We hypothesised that lamellar lesions consistent with laminitis would be associated with PPID, even in animals without current or historical laminitis. Prospective case-control study. Mid-dorsal hoof histological sections were obtained post mortem from the forelimbs of 16 PPID-affected animals either with (n = 6) or without laminitis (n = 10) and 10 age- and breed-matched controls. Sections were examined by a blinded veterinary pathologist. The length and width of 10 primary epidermal lamellae were measured using image analysis software. The morphology and pathology of primary and secondary epidermal lamellae were then typed or graded in axial, middle and abaxial regions. Fasting serum insulin, plasma adrenocorticotropin and blood glucose concentration were measured from blood samples taken prior to euthanasia. All animals with PPID and laminitis had fasting hyperinsulinaemia (median 74.1 miu/l, interquartile range 49.9-349.5 miu/l) whereas PPID animals without laminitis had serum insulin concentrations below the upper limit of the reference range (morphological alteration and pathology consistent with laminitis. © 2015 EVJ Ltd.

  11. Monitoreo de parásitos en efluentes domiciliarios

    Directory of Open Access Journals (Sweden)

    Semenas Liliana

    1999-01-01

    Full Text Available OBJETIVO: Evaluar la presencia de parásitos en efluentes semisólidos y líquidos en distintas localidades de la Patagonia argentina considerando que ésta es una de las restricciones para su uso. MÉTODOS: Las muestras tomadas en 4 Plantas de Tratamiento de Efluentes Domiciliarios se analizaron siguiendo las normativas de Environmental Protection Agency, Organización Mundial de la Salud, Standard Methods for Examination of Water and Wastewater y de algunas clasificaciones. RESULTADOS: Solamente 2 de las 6 muestras de semisólidos analizadas tenían huevos de Ascaris lumbricoides no viables. De las 10 muestras líquidas, solamente 2 no tenían huevos mientras las restantes tenían patógenos de las categorías I (Giardia sp., Hymenolepis diminuta y Enterobius vermicularis y III (Ascaris lumbricoides, Ancylostoma duodenale y Trichuris trichiura. CONCLUSIONES: Todas las muestras de semisólidos analizadas fueron aptas para su uso como fertilizantes porque no se registró en ninguna de ellas la presencia de huevos viables de Ascaris lumbricoides y solamente 6 de las muestras líquidas fueron aptas para riego por carecer de huevos o por ser su concentración igual o inferior a 1 huevo por litro.

  12. Characterization of ParTI Phoswiches Using Charged Pion Beams

    Science.gov (United States)

    Churchman, Emily; Zarrella, Andrew; Youngs, Michael; Yennello, Sherry

    2017-09-01

    The Partial Truncated Icosahedron (ParTI) detector array consists of 15 phoswiches. Each phoswich is made of two scintillating components - a thallium-doped cesium iodide (CsI(Tl)) crystal and an EJ-212 scintillating plastic - coupled to a photomultiplier tube. Both materials have different scintillation times and are sensitive to both charged and neutral particles. The type of particle and amount of energy deposited determine the shape of the scintillation pulse as a function of time. By integrating the fast and slow signals of the scintillation pulses, a ``Fast vs. Slow Integration'' plot can be created that produces particle identification lines based on the energy deposited in the scintillating materials. Four of these phoswiches were taken to the Paul Scherrer Institute (PSI) in Switzerland where π + , π-, and proton beams were scattered onto the phoswiches to demonstrate their particle identification (PID) capabilities. Using digitizers to record the detector response waveforms, pions can also be identified by the characteristic decay pulse of the muon daughters.

  13. Hunger amidst plenty along the coast of Pará

    Directory of Open Access Journals (Sweden)

    Ivete Nascimento

    2006-08-01

    Full Text Available In this work one analyzes some referring questions to the new significações of the temporality constructed socially enters the artisan fishing of the coast, in the city of Maracanã, using as boundary-maker the concepts the concepts of abundance and famitura the one that they send themselves to the speech in way of life of the past and the gift. It will see as the typical way of life of the rescued past of the memory of old and the meaning of the abundance in the time of the fishing-farmer, the counterpoint with the concept of famitura of the fishing-exclusive of the gift, where the loss surpasses the scope of the strict survival reaching the proper way of life with the weakness of solidarity. This analysis will be given mecanicamente in the conceptual field of the time measured for the tasks and of the time chronometered for the clock. The intensive field work ocurred on Fortaleza of the Mocooca community incorporating data gotten a long the author's experience in the fish artisan thematic of the Pará coast.

  14. Gastro-intestinale klachten bij meningokokkeninfectie: Opkomst van serogroep W

    NARCIS (Netherlands)

    Wunderink, H F; Vlasveld, I N; Knol, M J; van der Ende, A; van Essen, E H R; Kuijper, E J

    2017-01-01

    Meningococcal disease usually presents as meningitis and/or septicaemia, but can also present as pneumonia or arthritis. Since 2000, a worldwide increase in meningococcal disease is reported which is caused by a new virulent clone of serogroup W (MenW:cc11). This subtype is more likely to give an

  15. 45 original article prevalences des infections intestinales de ...

    African Journals Online (AJOL)

    boaz

    46 water, food and person to person especially with poor basic hygiene or lack of sanitation (3). Intestinal parasitic infections have been linked with increased malnutritional anaemia, protein-energy malnutrition and growth deficit in children (4, 5). Intestinal protozoan's infestation is most common among school age children ...

  16. Statut nutritionnel et parasitoses (intestinales et urinaires) chez les ...

    African Journals Online (AJOL)

    ... d'y associer un traitement efficace contre les parasites intestinaux et urinaires. Mots-cles: Enfant, Ecole, Statut nutritionnel, IMC pour age, parasitoses, Burkina Faso. Nutritional status and parasites (intestinal and urinary) infections among school-age children in Burkina Faso: case study of Yamtenga, Koubri and Daguilma ...

  17. Characterization of a dodecapeptide containing a dominant epitope of Par j 1 and Par o 1, the major allergens of P. judaica and P. officinalis pollen.

    Science.gov (United States)

    Menna, T; Cassese, G; Di Modugno, F; Chersi, A; Buono, C; Ruffilli, A

    1999-10-01

    The pollen of Parietaria, a weed of the Urticaceae family, is a major cause of respiratory allergy in Europe, where the most common species are P. judaica and P. officinalis. Previously, we reported that a beta-galactosidase fusion protein (6a-BG) expressing a 26-bp cDNA fragment (6a cDNA) contained a dominant IgE-binding epitope (6a epitope) of the major allergens Par o 1 and Par j 1. The present study aimed to define the amino-acid sequence containing the 6a epitope. We analyzed the reactivity of anti-Par o 1 antibodies affinity purified from allergic patient sera with: 1) a panel of synthetic peptides deduced from the 6a nucleotide sequence using different reading frames 2) glutathione S-transferase (GST) fusion proteins containing selected peptides. The peptide NSARARADSCRI (p102) specifically bound anti-Par o 1 antibodies affinity purified from allergic patient sera or from rabbit anti-Par o 1 antiserum (ELISA). The related peptide NSARAGTSSCRI (p101) reacted to human but not to rabbit, anti-Par o 1 antibodies. GST fusion proteins containing p101 (GST 3.5) or p102 (GST 3.2) extensively inhibited the binding between Par o 1 and IgE or IgG antibodies from an allergic patient serum pool according to a dose-response curve. Percent inhibition of IgE antibodies binding obtained by absorbing a solution (50 microl) of affinity-purified antibodies with 5 microg of GST 3.2 or with 1.2 mg of GST 3.5 was 69% and 66%, respectively. In conclusion, the results of the present study indicate that the amino-acid sequences NSARARADSCRI (p102) and NSARAGTSSCRI (p101) contain the dominant epitope of Par o 1 and Par j 1 for human IgE and IgG antibodies indicated as 6a epitope. Moreover, the study shows that the epitope is conserved in recombinant molecules containing these peptides, irrespective of the fused polypeptide (beta-galactosidase or GST). The knowledge of the amino-acid sequence of this dominant epitope is important in therapeutic approaches to the development of allergen

  18. Effects of solar PAR and UV radiation on tropical biofouling communities

    KAUST Repository

    Dobretsov, SV

    2010-03-08

    We investigated the effect of solar ultraviolet radiation (UVR) and photosynthetically active radiation (PAR) on the development of tropical micro- and macrofouling communities for 30 d. The experimental design involved 3 treatments: full spectrum (PAR+UVR), PAR only, and minimal light (reduced PAR and UVR). Terminal restriction fragment length polymorphism analysis demonstrated that different light conditions resulted in the formation of highly different microbial communities. The lowest densities of bacteria were found under the full spectrum treatment, while the lowest densities of diatoms were found in the minimal light treatment. Macrofouling communities consisted of 13 species and differed among light treatments. In the presence of UVR, communities had low species diversity, evenness, and richness, while in minimal light and PAR treatments, communities had high species diversity, evenness, and richness. Similarity percentage (SIMPER) analysis revealed that the tubeworm Hydroides elegans, the alga Ulva (Enteromorpha) sp., and the bivalve Perna viridis were the species responsible for most of the dissimilarities in macrofouling communities among treatments. While densities of H. elegans were similar in the PAR and minimal light treatments, this polychaete had higher growth rates under minimal light conditions. We conclude that UVR and PAR directly control the development of shallow micro- and macrofouling communities by inhibiting the recruitment and growth of sensitive species and promoting the growth of resistant species, but also that these forms of solar radiation influence the surface cues available to competent larvae by altering the development of the microbial community.

  19. Blocking PAR2 alleviates bladder pain and hyperactivity via TRPA1 signal

    Directory of Open Access Journals (Sweden)

    Chen Daihui

    2016-01-01

    Full Text Available Bladder disorders associated with interstitial cystitis are frequently characterized by increased contractility and pain. The goals of this study were to examine 1 the effects of blocking proteinase-activated receptor-2 (PAR2 on the exaggerated bladder activity and pain evoked by cystitis and 2 the underlying mechanisms responsible for the role of PAR2 in regulating cystic sensory activity. The protein expression of PAR2 was amplified in rats with cystitis by inducing it with systemic administration of cyclophosphamide (CYP as compared with control rats. Blocking PAR2 by intrathecal infusion of PAR2 antagonist FSLLRY-NH2 attenuated bladder hyperactivity and pain. In addition, blocking PAR2 attenuated the transient receptor potential A1 (TRPA1 signal pathway, whereas inhibition of the TRPA1 decreased bladder hyperactivity and pain. The data revealed specific signaling pathways leading to CYP-induced bladder hyperactivity and pain, including the activation of PAR2 and TRPA1. Inhibition of these pathways alleviates cystic pain. Targeting one or more of these signaling molecules may present new opportunities for treatment and management of overactive bladder and pain often observed in cystitis.

  20. Caractérisation par ellipsométrie spectroscopique de films minces de tellurure de bismuth obtenus par voie électrochimique

    Science.gov (United States)

    Zimmer, A.; Stein, N.; Boulanger, C.; Johann, L.

    2004-12-01

    Des films de tellurure de bismuth (Bi2Te3) d’épaisseur proche de 1 mm ont été développés par voie électrochimique. Leurs indices optiques ont été déterminés par ellipsométrie spectroscopique (SE). Le domaine spectral des indices optiques s’étend de 400 nm à 1300 nm. L’ellipsométrie spectroscopique à angle d’incidence variable (VASE) a été utilisée pour corréler les données SE. Cette partie a été complétée par des analyses par microscopie à force atomique (AFM) qui ont permis de déterminer la rugosité des films. A partir de ces résultats et en associant l’absorption fondamentale des films de Bi2Te3 à une transition indirecte, l’énergie de bande interdite a été évaluée à 0,3 eV. Par ailleurs des mesures associant ellipsométrie spectroscopique à temps réel et électrochimie ont pu être réalisées. Ainsi les premiers instants de croissance ont été observés.

  1. Expression of prostate apoptosis response (Par-4) is associated with progesterone receptor in breast cancer.

    Science.gov (United States)

    Zapata-Benavides, Pablo; Méndez-Vázquez, José L; González-Rocha, Talina R; Zamora-Avila, Diana E; Franco-Molina, Moises A; Garza-Garza, Raúl; Rodriguez-Padilla, Cristina

    2009-10-01

    The prostate apoptosis response (Par-4) gene encodes a proapoptotic protein that selectively induces apoptosis in cancer cells after diverse apoptotic stimuli. Par-4 expression and its association with other biomarkers have not been reported in breast cancer. The purpose of this study was to determine Par-4 expression in breast cancer samples and its association with other biomarkers and clinical factors (T-stage, age, nodal status). Paraffin-embedded section samples of breast cancer were evaluated by immunohistochemical analysis to determine Par-4, estrogen receptor (ER), progesterone receptor (PgR), c-erbB2, Ki67, p53 and bcl-2 expression. The correlation between Par-4 and the other biomarkers and clinical factors was determined by multivariate analysis. Thirty five percent (n=21) of samples were PAR-4 positive and 64.4% (n=38) were negative. The hormonal status was 64% ER positive (n=38), 35% ER-negative (n=21) and 40.7% PgR positive (n=24), 59.3% PgR negative (n=35). The majority (90%) of the samples presented clear cytoplasmic localization and a small portion (10%) was cytoplasmic and nuclear. Univariate analysis indicates that the Par-4 expression has a significant inverse association (p=0.04) only with expression of PgR and not with the other variables analyzed. Normal breast tissue analyzed was negative for Par-4 immunostaining. Our results suggest that, in breast cancer, Par-4 plays a similar tumor suppressor gene role as reported in endometrial carcinoma. 2009. Published by Elsevier Inc.

  2. The urokinase receptor (uPAR facilitates clearance of Borrelia burgdorferi.

    Directory of Open Access Journals (Sweden)

    Joppe W R Hovius

    2009-05-01

    Full Text Available The causative agent of Lyme borreliosis, the spirochete Borrelia burgdorferi, has been shown to induce expression of the urokinase receptor (uPAR; however, the role of uPAR in the immune response against Borrelia has never been investigated. uPAR not only acts as a proteinase receptor, but can also, dependently or independently of ligation to uPA, directly affect leukocyte function. We here demonstrate that uPAR is upregulated on murine and human leukocytes upon exposure to B. burgdorferi both in vitro as well as in vivo. Notably, B. burgdorferi-inoculated C57BL/6 uPAR knock-out mice harbored significantly higher Borrelia numbers compared to WT controls. This was associated with impaired phagocytotic capacity of B. burgdorferi by uPAR knock-out leukocytes in vitro. B. burgdorferi numbers in vivo, and phagocytotic capacity in vitro, were unaltered in uPA, tPA (low fibrinolytic activity and PAI-1 (high fibrinolytic activity knock-out mice compared to WT controls. Strikingly, in uPAR knock-out mice partially backcrossed to a B. burgdorferi susceptible C3H/HeN background, higher B. burgdorferi numbers were associated with more severe carditis and increased local TLR2 and IL-1beta mRNA expression. In conclusion, in B. burgdorferi infection, uPAR is required for phagocytosis and adequate eradication of the spirochete from the heart by a mechanism that is independent of binding of uPAR to uPA or its role in the fibrinolytic system.

  3. MMP-1/PAR-1 signal transduction axis and its prognostic impact in esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Hong-hua Peng

    2012-01-01

    Full Text Available The matrix metalloprotease-1 (MMP-1/protease-activated receptor-1 (PAR-1 signal transduction axis plays an important role in tumorigenesis. To explore the expression and prognostic value of MMP-1 and PAR-1 in esophageal squamous cell carcinoma (ESCC, we evaluated the expression of two proteins in resected specimens from 85 patients with ESCC by immunohistochemistry. Sixty-two (72.9% and 58 (68.2% tumors were MMP-1- and PAR-1-positive, respectively, while no significant staining was observed in normal esophageal squamous epithelium. MMP-1 and PAR-1 overexpression was significantly associated with tumor node metastasis (TNM stage and regional lymph node involvement. Patients with MMP-1- and PAR-1-positive tumors, respectively, had poorer disease-free survival (DFS than those with negative ESCC (P = 0.002 and 0.003, respectively. Univariate analysis showed a significant relationship between TNM stage [hazard ratio (HR = 2.836, 95% confidence interval (CI = 1.866-4.308], regional lymph node involvement (HR = 2.955, 95%CI = 1.713-5.068, MMP-1 expression (HR = 2.669, 95%CI = 1.229-6.127, and PAR-1 expression (HR = 1.762, 95%CI = 1.156-2.883 and DFS. Multivariate analysis including the above four parameters identified TNM stage (HR = 2.035, 95%CI = 1.167-3.681, MMP-1 expression (HR = 2.109, 95%CI = 1.293-3.279, and PAR-1 expression (HR = 1.967, 95%CI = 1.256-2.881 as independent and significant prognostic factors for DFS. Our data suggest for the first time that MMP-1 and PAR-1 were both overexpressed in ESCC and are novel predictors of poor patient prognosis after curative resection. The MMP-1/PAR-1 signal transduction axis might be a new therapeutic target for future therapies tailored against ESCC.

  4. Wetting Alteration of Solid Surfaces by Crude Oils and Their Asphaltenes Modification de la mouillabilité des surfaces solides par les pétroles bruts et leurs asphaltènes

    Directory of Open Access Journals (Sweden)

    Buckley J. S.

    2006-12-01

    éparer du pétrole en réaction à des modifications du pouvoir solvant du pétrole. Du fait qu'ils changent de taille, les asphaltènes peuvent être considérés soit comme des macromolécules, soit comme des colloïdes. Leur influence sur la mouillabilité peut varier selon que le régime est plutôt moléculaire ou plutôt colloïdal. En tant que macromolécules, les asphaltènes et les autres constituants du pétrole possédant des fonctions polaires peuvent s'adsorber sur les surfaces minérales. Il est établi que de nombreux pétroles différents modifient la mouillabilité de surfaces silicatées sèches de façon similaire. En présence d'eau, toutefois, les résultats de l'exposition de surfaces à différentes huiles peuvent être fort complexes, en fonction de la distribution de l'eau, des compositions de l'huile et de l'eau, et de la minéralogie des surfaces. Les indices d'acidité et de basicité, ainsi que les relations entre ces deux paramètres procurent une mesure de la faculté d'une huile donnée à modifier la mouillabilité par des mécanismes ioniques. En tant que colloïdes, les asphaltènes peuvent modifier la mouillabilité par un mécanisme supplémentaire. Au voisinage du seuil de précipitation, le changement de mouillabilité intervient par précipitation superficielle à cause de l'agrégation des asphaltènes colloïdaux à l'interface, qui peut précéder la floculation d'ensemble. L'influence des asphaltènes sur la mouillabilité dépend donc fortement de l'environnement dans lequel ils se trouvent. L'indice de réfraction du mélange est une mesure utile pour quantifier la stabilité des asphaltènes dans un pétrole brut et donc, aussi, pour séparer les contributions moléculaire et colloïdale dans les changements de mouillabilité induits par les asphaltènes.

  5. Provenance of the oil in par-fried French fries after finish frying.

    Science.gov (United States)

    Al-Khusaibi, Mohammed; Gordon, Michael H; Lovegrove, Julie A; Niranjan, Keshavan

    2012-01-01

    Frozen par-fried French fries are finish-fried either by using the same type of oil used for par frying, or a different type. The nutritive quality of the final oil contained in the product depends on the relative amounts and the fatty acid (FA) composition of the oils used for par frying and finish frying. With the aim of understanding the provenance of the oil in the final product, par-fried French fries-either purchased ready or prepared in the laboratory-were finish fried in oils different from the ones used for par frying. The moisture content, oil content, and FA compositions of the par-fried and finish-fried products were experimentally determined, and the relative amounts of each of the oils present in the final product were calculated using the FAs as markers and undertaking a mass balance on each component FA. The results demonstrate that 89% to 93% of the total oil in the final product originates from the finish-frying step. The study also shows that a significant proportion of the oil absorbed during par frying is expelled from the product during finish frying. Further, the expulsion of par-frying oil was found to occur in the early stages of the finish-frying step. Experiments involving different combinations of par-frying and finish-frying oils showed that the relative proportions of the 2 oils did not depend on the individual fatty acid profiles. This study concludes that any positive health benefits of using an oil having a favorable FA profile for par frying, can potentially be lost, if the oil used for finish frying has a less favorable composition. This paper estimates the relative amounts of oil in French fries that have been fried in 2 stages-a par-frying step and a finish-frying step-which is commonly practiced in food service establishments as well as homes. The 2 key conclusions are: (1) nearly 90% of the oil content of the final product is the one used for finish frying; that is, a processor may use very good oil for par frying but if the

  6. Influence of P-Reactor operation on the aquatic ecology of Par Pond: a literature review

    International Nuclear Information System (INIS)

    Wilde, E.W.; Tilly, L.J.

    1985-02-01

    Par Pond is a 1012 hectare reservoir that was constructed in 1958 to provide cooling water for Savannah River nuclear reactors. The purpose of this report is to summarize all known studies on the Par Pond system and point out demonstrable or probable effects that can be correlated with reactor operations. Reactor operation effects the Par Pond ecosystem through: (1) pumping, (2) thermal alteration, and (3) the addition of Savannah River makeup water. The influence of each of these factors is discussed. 108 references, 24 figures, 34 tables. (MF)

  7. Profils des enfants infectes par le vih en debut du traitement ...

    African Journals Online (AJOL)

    But : Décrire les profils des enfants infectés par le VIH au début du traitement antirétroviral. Matériels et méthode: Les dossiers des enfants infectés par le VIH dans la région maritime ont été analysés de mai 2008 à février 2010 par le comité thérapeutique. Résultats: Parmi les 96 dossiers analysés, 66,67% venaient du ...

  8. Les dispensées par fantaisie en éducation physique et sportive ...

    African Journals Online (AJOL)

    Cette étude vise à comprendre les raisons avancées par les élèves dispensés par fantaisie des cours d'EPS, pour justifier leur attitude et principalement leur forfait. Une enquête par questionnaire écrit a été menée dans 13 établissements publics de la ville de Porto-Novo au Bénin. Au total, 203 élèves parmi les 771 élèves ...

  9. Thrombin induces rapid PAR1-mediated non-classical FGF1 release

    International Nuclear Information System (INIS)

    Duarte, Maria; Kolev, Vihren; Soldi, Raffaella; Kirov, Alexander; Graziani, Irene; Oliveira, Silvia Marta; Kacer, Doreen; Friesel, Robert; Maciag, Thomas; Prudovsky, Igor

    2006-01-01

    Thrombin induces cell proliferation and migration during vascular injury. We report that thrombin rapidly stimulated expression and release of the pro-angiogenic polypeptide fibroblast growth factor 1 (FGF1). Thrombin failed to induce FGF1 release from protease-activated receptor 1 (PAR1) null fibroblasts, indicating that this effect was dependent on PAR1. Similarly to thrombin, FGF1 expression and release were induced by TRAP, a specific oligopeptide agonist of PAR1. These results identify a novel aspect of the crosstalk between FGF and thrombin signaling pathways which both play important roles in tissue repair and angiogenesis

  10. Structure and ligand interactions of the urokinase receptor (uPAR)

    DEFF Research Database (Denmark)

    Kjaergaard, Magnus; Hansen, Line V.; Jacobsen, Benedikte

    2008-01-01

    The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the serine protease uPA. This tight interaction (KD less than 1 n...... on disulfide connectivities, and they adopt a characteristic three-finger fold. Interestingly, the gene for uPAR is localized in a cluster of 6 homologous genes encoding proteins with multiple LU-domains. The structural biology of uPAR will be reviewed with special emphasis on its multidomain composition...

  11. Data on the regulation of moesin and merlin by the urokinase receptor (uPAR: Model explaining distal activation of integrins by uPAR

    Directory of Open Access Journals (Sweden)

    Bernard Degryse

    2017-12-01

    Full Text Available The data presented herein are connected to our research article (doi: 10.1016/j.biocel.2017.04.012 [1], in which we investigated the functional connections between the urokinase receptor (uPAR, and the ezrin/radixin/moesin (ERM proteins, moesin and merlin [1]. Firstly, a model of action is proposed that enlightens how uPAR regulates distal integrins. In addition, data show the effects of expressing wild-type moesin or permanently active T558D mutant of moesin on angiogenesis and morphology of human aortic endothelial cells (HAEC. Additional data compare the effects of urokinase (uPA, the main ligand of uPAR on the same cells. Lastly, we provide technical data demonstrating the effects of specific siRNA for moesin and merlin on moesin and merlin expression, respectively. Keywords: Urokinase receptor, Moesin, Merlin, Angiogenesis, siRNA

  12. Cross section measurements of the processes occurring in the fragmentation of H{sub n}{sup +} (3 {<=} n {<=} 35) hydrogen clusters induced by high speed (60 keV/u) collisions on helium atoms; Mesure des sections efficaces des differents processus intervenant dans la fragmentation d`agregats d`hydrogene H{sub n}{sup +} (3 {<=} n {<=} 35) induite par collision a haute vitesse (60 keV/u) sur un atome d`helium

    Energy Technology Data Exchange (ETDEWEB)

    Louc, Sandrine [Inst. de Physique Nucleaire, Lyon-1 Univ., 69 - Villeurbanne (France)

    1997-09-15

    Different processes involved in the fragmentation of ionised hydrogen clusters H{sub 3} + (H{sub 2}){sub (n-3)/2} (n = 5-35) have been studied in the same experiment: the fragmentation of the cluster is induced by the collision with an helium atom at high velocity ({approx_equal} c/100). The collision is realised in reversed kinematic - clusters are accelerated - which allows the detection of neutral and charged fragments. The different channels of fragmentation are identified by using coincidence techniques. For all the cluster sizes studied the capture cross sections of one electron of the target by the cluster is equal to the capture cross section of the H{sub 3}{sup +} ion. In the same way, the dissociation cross section of the H{sub 3}{sup +} core of the cluster does not depend on cluster size. These fragmentation processes are due to the interaction of H{sub 3}{sup +} core of the cluster and the helium atom without ionization of another component of the cluster. On the contrary, the cross sections of loss of one, two and three molecules by the cluster and the dissociation cross section of the cluster in all its molecular components depends strongly on the cluster size. This dependence is different from the one measured for the metastable decay of the cluster. Thus, the process of loss of molecules induced by a collision should correspond to a different dissociation mechanism. In regard of the singularities observed for the size dependence, the H{sub 9}{sup +}, H{sub 15}{sup +}, H{sub 19}{sup +} and H{sub 29}{sup +} clusters could be the `core` of the biggest clusters. These observation are in agreement with the size effects of smaller magnitude observed for the dissociation cross section (all the processes). The values of the cross section for the process of at least one ionization of the cluster indicate that about 80% of the fragmentation events result from this process. (author) 114 refs., 74 figs., 9 tabs.

  13. Potential interest to combine an intensity modulated conformal radiotherapy (I.M.C.R.T.) with a daily repositioning on intra-prostate implants to reduce sexual toxicity induced by exclusive irradiation of prostate cancers; Interets potentiels de combiner une radiotherapie de conformation avec modulation d'intensite (RCMI) avec un repositionnement journalier sur implants intraprostatiques pour reduire la toxicite sexuelle induite par l'irradiation exclusive des cancers de prostate

    Energy Technology Data Exchange (ETDEWEB)

    Chapet, O.; Sotton, M.P.; Vial, L.; Belliere, A.; Ardiet, J.M.; Mornex, F.; Sentenac, I.; Romestaing, P. [Centre Hospitalier Lyon-Sud, Dept. de Radiotherapie-oncologie, 69 - Pierre-Benite (France); Bouffard, J. [Centre Hospitalier Lyon-Sud, Service de Radiologie, 69 - Pierre-Benite (France)

    2007-11-15

    A reduction in margins defining the forecast target volume thanks to a daily repositioning on intra prostate implants would reduce the doses delivered to the penis bulb, corpora cavernosa penis and a. pudendae internae left and right. An optimization of the I.M.C.R.T. on the same anatomical structures amplifies this earnings. The combination of the two could improve the sexual preservation and be proposed for patients with favourable stage prostate cancer. A study of Phase 2 begins soon. (N.C.)

  14. Measurements of gas and volatile element production rates from an irradiated molten lead and lead-bismuth spallation target with proton beams of 1 and 1.4 GeV; Mesures de taux de production d'elements gazeux et volatiles lors de reactions induites par des protons de 1 et 1,4 GeV sur des cibles epaisses de plomb et plomb-bismuth liquides

    Energy Technology Data Exchange (ETDEWEB)

    Tall, Y

    2008-03-15

    The integrated project EUROTRANS (European Research Programme for the Transmutation of High Level Nuclear Waste in an Accelerator Driven System) of the 6. EURATOM Framework Programme aims to demonstrate the transmutation of radioactive waste in ADS (Accelerator Driven Sub-critical system). It will carry out a first advanced design of an experimental facility to demonstrate the technical feasibility of transmutation, and will produce a conceptual design of an industrial facility dedicated to transmutation. An ADS consists of three fundamental elements: the accelerator of protons, the sub-critical core and the spallation target. SUBATECH (physique Sub-Atomique et des Technologies associees) laboratory is involved to the study of the chosen liquid lead-bismuth as a spallation ADS target. The irradiation of liquid lead-bismuth target with energetic proton beam generates in addition to neutrons, volatile and radioactive residues. In order to determine experimentally the production rates of gas and volatile elements following a spallation reaction in a lead-bismuth target, the experiment IS419 was performed at the ISOLDE facility at CERN (Centre Europeen de la Recherche Nucleaire). This experiment constitutes the frame of the thesis whose main objective is to assess and study the production and release rates of many gas and volatile element from the irradiated lead-bismuth target with an energetic proton beam. The obtained data are compared to Monte Carlo simulation code (MCNPX) results in order to test the intranuclear cascade model of Bertini and of Cugnon, and the evaporation options of Dresner and Schmidt. (author)

  15. Incidence of endophthalmitis after 23-gauge pars plana vitrectomy.

    Science.gov (United States)

    Lin, Zhong; Feng, Xiaofen; Zheng, Liya; Moonasar, Nived; Shen, Lijun; Wu, Ronghan; Chen, Feng

    2018-01-23

    Endophthalmitis is a rare but severe complication following PPV. The incidence of endophthalmitis varies between 20-gauge, 23-gauge, and 25-gauge incisions. The incidence and clinical features of endophthalmitis after 23-gauge PPV in an eye hospital in China was reported in this study. Data of the eyes that underwent 23-gauge PPV from January 2011 to December 2014 at the Eye Hospital of Wenzhou Medical University was retrospectively collected. All the information was obtained from the electronic medical system. The exclusion criteria included: (1) preoperative diagnosis of endophthalmitis; (2) history of vitrectomy; (3) intraocular surgery within 6 months; (4) history of ocular penetrating trauma; (5) sutures for any of the 3 sclerotomy incisions; (6) patients with cancer, acquired immune deficiency syndrome, or taking drugs that may influence the immune system. The diagnosis of endophthalmitis was based on clinical characteristics and/or culture results from an operative sample. Three thousand nine hundred seventy nine eyes that underwent 23-gauge PPV surgery were included in this study. Among these eyes, 3 eyes developed endophthalmitis after surgery, giving an incidence of 0.075% (3/3979). The period in which endophthalmitis developed ranged from 1 to 5 days post-operation. The visual acuity decreased to hand motions or light perception postoperatively. The culture of aqueous and vitreous of the 2 eyes revealed Staphylococcus epidermidis and enterococcus faecalis respectively, however was negative for the third eye. All 3 eyes had a favorable response to the treatment of vitreous tap and intravitreal antibiotics injection. Two eyes gained visual acuity of 0.05 and 0.5, respectively at the final visit. Endophthalmitis is a rare but sight-threatening complication after 23-gauge pars plana vitrectomy. The peak duration of onset was within 5 days post-operation, with gram positive cocci being the common pathogenic organism.

  16. La relecture du romancero par les vihuelistes de la Renaissance

    Directory of Open Access Journals (Sweden)

    Pascal Martel

    1999-01-01

    Full Text Available Les romances espagnols de la Reconquête relataient sur le mode épique des faits passés sur une mélodie récurrente qui servait surtout d’outil mnémotechnique pour réciter de longues narrations. Lorsque Diego Pisador reprend un romance, il n’en prend que quelques vers : du coup, le rapport entre les mots et les notes se fait plus étroit. D’un poème épique, il élabore une amplification lyrique, une véritable composition musicale, opère un véritable changement d’esthétique : le passage de la longue narration sur un thème musical bref et récurrent qui caractérisait le romance médiéval de la Reconquista, à une forme musico-littéraire plus brève mais plus élaborée, propre à introduire la vibration lyrique dans la matière épique. Familier de la Cour, il entend ainsi servir les desseins politiques de Philippe Il à qui il dédie son œuvre : le compositeur vihueliste qu’était Pisador en effet participe à l’effort de l’intégration du Maure poursuivi par la politique de la Maison d’Autriche. Mais les noces n’eurent pas lieu et les Maures furent au contraire expulsés en 1609. L’analyse de cette chanson nous donne l’occasion de découvrir les moyens employés par le musicien pour se livrer à une véritable amplification lyrique d’un simple récit par la musique. La chanson savante n’est pas non plus une composition dans laquelle la mélodie traduirait simplement en musique le texte poétique de façon tout à fait parallèle : la musique n’est pas qu’une répétition, sous une autre forme, de la parole, ou bien l’image sonore d’un texte. Musique et poésie constituent deux moyens autonomes d’expression mais qui, dans une chanson, concourent à un même but : ces deux moyens d’expression tantôt se rejoignant, tantôt s’émancipant l’un de l’autre, de sorte que le propre de la chanson réside justement dans cette tension constante entre ses deux composantes. La mise en musique

  17. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of abou...... in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes....

  18. Developpement de techniques de diagnostic non intrusif par tomographie optique

    Science.gov (United States)

    Dubot, Fabien

    Que ce soit dans les domaines des procedes industriels ou de l'imagerie medicale, on a assiste ces deux dernieres decennies a un developpement croissant des techniques optiques de diagnostic. L'engouement pour ces methodes repose principalement sur le fait qu'elles sont totalement non invasives, qu'elle utilisent des sources de rayonnement non nocives pour l'homme et l'environnement et qu'elles sont relativement peu couteuses et faciles a mettre en oeuvre comparees aux autres techniques d'imagerie. Une de ces techniques est la Tomographie Optique Diffuse (TOD). Cette methode d'imagerie tridimensionnelle consiste a caracteriser les proprietes radiatives d'un Milieu Semi-Transparent (MST) a partir de mesures optiques dans le proche infrarouge obtenues a l'aide d'un ensemble de sources et detecteurs situes sur la frontiere du domaine sonde. Elle repose notamment sur un modele direct de propagation de la lumiere dans le MST, fournissant les predictions, et un algorithme de minimisation d'une fonction de cout integrant les predictions et les mesures, permettant la reconstruction des parametres d'interet. Dans ce travail, le modele direct est l'approximation diffuse de l'equation de transfert radiatif dans le regime frequentiel tandis que les parametres d'interet sont les distributions spatiales des coefficients d'absorption et de diffusion reduit. Cette these est consacree au developpement d'une methode inverse robuste pour la resolution du probleme de TOD dans le domaine frequentiel. Pour repondre a cet objectif, ce travail est structure en trois parties qui constituent les principaux axes de la these. Premierement, une comparaison des algorithmes de Gauss-Newton amorti et de Broyden- Fletcher-Goldfarb-Shanno (BFGS) est proposee dans le cas bidimensionnel. Deux methodes de regularisation sont combinees pour chacun des deux algorithmes, a savoir la reduction de la dimension de l'espace de controle basee sur le maillage et la regularisation par penalisation de Tikhonov

  19. A biomechanic study of the surgical repair technique of pars defect in spondylolysis.

    Science.gov (United States)

    Vathana, P; Prasartritha, T

    1998-11-01

    To find out which wiring technique of direct repair of the pars defect is the strongest in resisting anteroposterior translation displacement, fifteen fresh human cadaveric L4-L5 spines were biomechanically tested by a universal testing machine. Two millimeters wide pars defect was created on both sides of L4 vertebrae. Each of the five specimens was wired using Nicol's technique (A), modified Nicol's technique (B) and modified pedicular screw technique respectively (C). At each test, motion was observed to occur initially at the pars defect. The mean minimum tensile strength (increment of the pars defect) for technique A, B and C was 87.64, 82.04 and 110.08 Kg Force respectively. By statistical analysis, technique C was the strongest in resisting anteroposterior displacement of the spinal column. There was no statistically significant difference between technique A and B.

  20. Remote sensing of global surface shortwave radiation and PAR over the ocean

    Science.gov (United States)

    Gautier, Catherine H.; Byers, Michael L.

    1992-12-01

    During the past few years many methods have been proposed for estimating surface radiative fluxes (shortwave radiation, photosynthetically active radiation - PAR) from satellite observations. We have developed algorithms for computing the shortwave radiative flux (shortwave irradiance) at the ocean surface from visible radiance observations and they have been found to be quite successful under most atmospheric and cloud conditions. For broken clouds, however, the simple plane parallel assumption for solving the radiative transfer equations may need to be corrected to account for cloud geometry. The estimation of PAR is simpler because the most commonly used satellite radiance measurements cover a similar region of the solar spectrum. We are in the process of producing global $ARDNSW and PAR as a contribution to the Sequoia 2000 project (to implement a distributed processing system designed for the needs of global change researchers). Results from our algorithms developed for Sequoia and preliminary global surface solar irradiance and PAR fields are presented and discussed.

  1. Disjonction symphysaire après un accouchement par voie basse ...

    African Journals Online (AJOL)

    Disjonction symphysaire après un accouchement par voie basse dystocique: à propos d'un cas. Meriem Laadioui, Wafae Slimani, Sofia Jayi, Fatimazahra Fdili Alaoui, Hakima Bouguern, Hikmat Chaara, Moulay Aabdelilah Melhouf ...

  2. ParTIES: a toolbox for Paramecium interspersed DNA elimination studies.

    Science.gov (United States)

    Denby Wilkes, Cyril; Arnaiz, Olivier; Sperling, Linda

    2016-02-15

    Developmental DNA elimination occurs in a wide variety of multicellular organisms, but ciliates are the only single-celled eukaryotes in which this phenomenon has been reported. Despite considerable interest in ciliates as models for DNA elimination, no standard methods for identification and characterization of the eliminated sequences are currently available. We present the Paramecium Toolbox for Interspersed DNA Elimination Studies (ParTIES), designed for Paramecium species, that (i) identifies eliminated sequences, (ii) measures their presence in a sequencing sample and (iii) detects rare elimination polymorphisms. ParTIES is multi-threaded Perl software available at https://github.com/oarnaiz/ParTIES. ParTIES is distributed under the GNU General Public Licence v3. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.

  3. Model parameterization to simulate and compare the PAR absorption potential of two competing plant species.

    Science.gov (United States)

    Bendix, Jörg; Silva, Brenner; Roos, Kristin; Göttlicher, Dietrich Otto; Rollenbeck, Rütger; Nauss, Thomas; Beck, Erwin

    2010-05-01

    Mountain pastures dominated by the pasture grass Setaria sphacelata in the Andes of southern Ecuador are heavily infested by southern bracken (Pteridium arachnoideum), a major problem for pasture management. Field observations suggest that bracken might outcompete the grass due to its competitive strength with regard to the absorption of photosynthetically active radiation (PAR). To understand the PAR absorption potential of both species, the aims of the current paper are to (1) parameterize a radiation scheme of a two-big-leaf model by deriving structural (LAI, leaf angle parameter) and optical (leaf albedo, transmittance) plant traits for average individuals from field surveys, (2) to initialize the properly parameterized radiation scheme with realistic global irradiation conditions of the Rio San Francisco Valley in the Andes of southern Ecuador, and (3) to compare the PAR absorption capabilities of both species under typical local weather conditions. Field data show that bracken reveals a slightly higher average leaf area index (LAI) and more horizontally oriented leaves in comparison to Setaria. Spectrometer measurements reveal that bracken and Setaria are characterized by a similar average leaf absorptance. Simulations with the average diurnal course of incoming solar radiation (1998-2005) and the mean leaf-sun geometry reveal that PAR absorption is fairly equal for both species. However, the comparison of typical clear and overcast days show that two parameters, (1) the relation of incoming diffuse and direct irradiance, and (2) the leaf-sun geometry play a major role for PAR absorption in the two-big-leaf approach: Under cloudy sky conditions (mainly diffuse irradiance), PAR absorption is slightly higher for Setaria while under clear sky conditions (mainly direct irradiance), the average bracken individual is characterized by a higher PAR absorption potential. (approximately 74 MJ m(-2) year(-1)). The latter situation which occurs if the maximum daily

  4. ParFit: A Python-Based Object-Oriented Program for Fitting Molecular Mechanics Parameters to ab Initio Data.

    Science.gov (United States)

    Zahariev, Federico; De Silva, Nuwan; Gordon, Mark S; Windus, Theresa L; Dick-Perez, Marilu

    2017-03-27

    A newly created object-oriented program for automating the process of fitting molecular-mechanics parameters to ab initio data, termed ParFit, is presented. ParFit uses a hybrid of deterministic and stochastic genetic algorithms. ParFit can simultaneously handle several molecular-mechanics parameters in multiple molecules and can also apply symmetric and antisymmetric constraints on the optimized parameters. The simultaneous handling of several molecules enhances the transferability of the fitted parameters. ParFit is written in Python, uses a rich set of standard and nonstandard Python libraries, and can be run in parallel on multicore computer systems. As an example, a series of phosphine oxides, important for metal extraction chemistry, are parametrized using ParFit. ParFit is in an open source program available for free on GitHub ( https://github.com/fzahari/ParFit ).

  5. Tsitutu , ou mecanisme local de mediation et de reconciliation « par ...

    African Journals Online (AJOL)

    Si le Togo est une nation pluriethnique, du coup, il y en aura des manières particulières de résolution des conflits, donc des réconciliations. Par une approche pluridisciplinaire, cette étude a pour but de restituer le mécanisme local de réconciliation chez les ewe de Kloto. Par ailleurs, ce rituel qui tente de proposer des ...

  6. La base de données sur les femmes entrepreneures soutenue par ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    6 août 2017 ... L'inclusion des femmes dans une base de données qui comprend des entreprises dirigées par des femmes les aidera énormément », ajoute-t-elle. Le CRDI appuie WEConnect dans l'auto-inscription et la certification électronique des entreprises dirigées par des femmes de toutes tailles qui ont besoin ...

  7. Etude par simulation hil des performances d'un statcom pour la ...

    African Journals Online (AJOL)

    Ce travail présente l'étude par simulation Hardware In the Loop (HIL) des performances d'un STATCOM pour la stabilisation de la tension délivrée par une génératrice asynchrone triphasée auto excitée dans un réseau autonome. Nous avons combiné l'utilisation du logiciel de simulation LABVIEW et la carte ARDUINO ...

  8. Infection par le VIH chez les patientes atteintes de cancer du sein en ...

    African Journals Online (AJOL)

    L'objectif était de déterminer la prévalence de l'infection à VIH chez les patientes atteintes de cancer du sein et de comparer les caractéristiques anatomocliques et thérapeutiques de ces cancers du sein par rapports aux patientes non infectées par le VIH. Il s'agissait d'une étude rétrospective et analytique comparant les ...

  9. Les corps etrangers des fosses nasales: Extraction par la pince d ...

    African Journals Online (AJOL)

    Les corps etrangers des fosses nasales: Extraction par la pince d'halsteaD. ... des fosses nasales: Extraction par la pince d'halsteaD. B Amana, E Kpemissi, P Agoda, A Naba-Mouchedou ... Les corps étrangers des fosses nasales représentent 0,94 % des consultations ORL du service. L'âge des patients a varié de 9 mois à ...

  10. La prise en charge des suicides par précipitation en traumatologie ...

    African Journals Online (AJOL)

    Introduction: A travers ce travail, l'épidémiologie et la psychopathologie du suicide par précipitation seront rappelées, le rôle du chirurgien traumatologue dans la restauration physique et psychique sera démontré. Méthodes: Nous rapportons une étude rétrospective de 15 suicidants par précipitation admis pour des ...

  11. Elimination du cadmium de l'acide phosphorique par électrodialyse

    African Journals Online (AJOL)

    L'efficacité d'élimination obtenue (31.4%) peut être améliorée par l'optimisation des autres paramètres tels que l'utilisation d'autres types de membranes. REFERENCES. [1] Boussen R., 2007. valorisation de l'acide phosphorique par precipitation du cadmium et pertraction de l'uranium. Thèse de doctorat d'état en chimie ...

  12. The superoxide scavenger TEMPOL induces urokinase receptor (uPAR expression in human prostate cancer cells

    Directory of Open Access Journals (Sweden)

    Francis Joseph

    2006-06-01

    Full Text Available Abstract There is little understanding of the effect that reactive oxygen metabolites have on cellular behavior during the processes of invasion and metastasis. These oxygen metabolites could interact with a number of targets modulating their function such as enzymes involved in basement membrane dissolution, adhesion molecules involved in motility or receptors involved in proliferation. We investigated the effect of increased scavenging of superoxide anions on the expression of the urokinase receptor (uPAR in PC-3M human prostate cancer cells. Urokinase receptor is a GPI-linked cell surface molecule which mediates multiple functions including adhesion, proliferation and pericellular proteolysis. Addition of the superoxide scavenger 4-hydroxy-2,2,6,6-tetramethylpiperidinyloxy (TEMPOL to PC-3M cultures stimulated expression of uPAR protein peaking between 48 and 72 hours. Cell surface expression of the uPAR was also increased. Surprisingly, uPAR transcript levels increased only slightly and this mild increase did not coincide with the striking degree of protein increase. This disparity indicates that the TEMPOL effect on uPAR occurs through a post-transcriptional mechanism. TEMPOL presence in PC-3M cultures reduced intracellular superoxide-type species by 75% as assayed by NBT dye conversion; however this reduction significantly diminished within hours following TEMPOL removal. The time gap between TEMPOL treatment and peak uPAR protein expression suggests that reduction of reactive oxygen metabolites in prostate cancer cells initiates a multistep pathway which requires several hours to culminate in uPAR induction. These findings reveal a novel pathway for uPAR regulation involving reactive oxygens such as superoxide anion.

  13. Compression robuste du signal par la transformée avec les B ...

    African Journals Online (AJOL)

    Par contre, elle diminue de façon considérable pour les b-splincs et les paquets dbndelcttes de Haar. Du point de vue entropie, la compression par bfsplines est bonne que celle de la TCD. Nous donnons ci-dessous un tableau récapitulatif des résultats de quelques méthodes utilisées pour deux signaux EMG. Le facteur de ...

  14. Le Sri Lanka mieux préparé aux futurs tsunamis | CRDI - Centre de ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    9 nov. 2012 ... Comme le rappelle Rohan Samarajiva, président du conseil d'administration et directeur général de LIRNEasia, ces essais ont révélé que la radio par satellite « adressable » était la technologie la plus fiable. Malheureusement, la faillite de la seule société de radiodiffusion par satellite en Asie a fait en ...

  15. Diagnostic moléculaire d'helicobacter pylori par PCR chez les ...

    African Journals Online (AJOL)

    Résultats: Les pathologies gastroduodénales étaient plus fréquentes chez les patients de plus de 45 ans. Les prévalences de H. pylori étaient respectivement de 88,57% et de 91,43% par sérologie Immunocomb et par PCR. La différence entre les deux techniques n'était pas significative (P = 0,573). La performance de la ...

  16. Brésil : La contamination par le mercure en Amazonie | CRDI ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    11 janv. 2011 ... ... site d'extraction de l'or. À sa grande surprise, ils sont demeurés stables jusqu'à 400 km du site. De toute évidence, même si l'extraction aurifère contribuait à la contamination par le mercure jusqu'à 50 km autour de la mine, elle n'était pas la principale cause de pollution par le mercure des cours d'eau en ...

  17. Prise en charge du spondylolisthesis par lyse isthmique a niamey, a ...

    African Journals Online (AJOL)

    Objectif Evaluer la prise en charge chirurgicale du spondylolisthésis par lyse isthmique à Niamey. Méthode Etude prospective en série continue réalisée dans le service de Neurochirurgie de Niamey de Janvier 1999 à Janvier 2006. Etaient inclus les spondylolisthésis par lyse isthmique. Les spondylolisthésis étaient ...

  18. L'émancipation des femmes et des collectivités africaines par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    23 nov. 2011 ... Ce que les chercheurs n'ont pas saisi dans le cas de Mercy, par exemple, c'est que les femmes perdent souvent le contrôle de la situation lorsque le fruit de leur labeur entre dans les systèmes financiers et marchés officiels, qui sont principalement régis par des hommes. Mme Njuki a découvert un ...

  19. Diffraction de rayons X sur les plaquettes de fer durcies par cyanuration

    Science.gov (United States)

    Popescu, M.; Hoyer, W.; Stegarescu, M.; Cornet, A.; Broll, N.

    2004-11-01

    Une méthode de cyanuration a été developpée pour les surfaces des plaquettes de fer, basée sur une réaction thermochimique qui conduit à la formation des couches dures sur le métal. Les échantillons ont été analysés, pour de temps différents de traitement, par diffraction de rayons X et par mesures de dureté.

  20. maladie de forestier revelee par une dysphagie a propos de deux cas

    African Journals Online (AJOL)

    18 juin 2007 ... L'imagerie par résonance magnétique (IRM) est indiquée en cas de complications neurologiques. Le transit oesophagien est demandé dans le cadre de l'ex- ploration d'une dysphagie (3). Le diagnostic de la maladie de Forestier se base sur des critères radiologiques établis par Resnick et al. (8) dans les.

  1. The RNA-binding protein ATX-2 regulates cytokinesis through PAR-5 and ZEN-4.

    Science.gov (United States)

    Gnazzo, Megan M; Uhlemann, Eva-Maria E; Villarreal, Alex R; Shirayama, Masaki; Dominguez, Eddie G; Skop, Ahna R

    2016-10-15

    The spindle midzone harbors both microtubules and proteins necessary for furrow formation and the completion of cytokinesis. However, the mechanisms that mediate the temporal and spatial recruitment of cell division factors to the spindle midzone and midbody remain unclear. Here we describe a mechanism governed by the conserved RNA-binding protein ATX-2/Ataxin-2, which targets and maintains ZEN-4 at the spindle midzone. ATX-2 does this by regulating the amount of PAR-5 at mitotic structures, particularly the spindle, centrosomes, and midbody. Preventing ATX-2 function leads to elevated levels of PAR-5, enhanced chromatin and centrosome localization of PAR-5-GFP, and ultimately a reduction of ZEN-4-GFP at the spindle midzone. Codepletion of ATX-2 and PAR-5 rescued the localization of ZEN-4 at the spindle midzone, indicating that ATX-2 mediates the localization of ZEN-4 upstream of PAR-5. We provide the first direct evidence that ATX-2 is necessary for cytokinesis and suggest a model in which ATX-2 facilitates the targeting of ZEN-4 to the spindle midzone by mediating the posttranscriptional regulation of PAR-5. © 2016 Gnazzo et al. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

  2. Par and IR reflectance, transmittance, and absorptance of four crop canopies

    International Nuclear Information System (INIS)

    Wanjura, D.F.; Hatfield, J.L.

    1986-01-01

    Reflectance, transmittance and absorptance of electromagnetic radiation by cotton, soybeans, grain sorghum, and sunflower was measured at three growth stages in two wavebands (PAR: 0.4 to 0.7 pun and IR: 0.7 to 1.1 yim). As leaf area increased in each crop there were increases in IR reflectance and PAR absorptance and decreases in PAR reflectance and both PAR and IR transmittance. IR radiation was concentrated at the soil surface between rows by reflectance from the sides of canopies when crop cover was less than 80%. Across all crops one parameter, leaf overlap index, explained 81 and 71% of the PAR reflectance and another, crop cover, explained 86 and 94% of IR reflectance from rows and interrows, respectively. Attenuation of PAR radiation through the canopies of cotton and sunflower was similar (K = 0.62 and 0.67) but different from that of soybeans and grain sorghum (K = 0.46 and 0.43) which were the same

  3. Par6b Regulates the Dynamics of Apicobasal Polarity during Development of the Stratified Xenopus Epidermis

    Science.gov (United States)

    Wang, Sha; Cha, Sang-Wook; Zorn, Aaron M.; Wylie, Christopher

    2013-01-01

    During early vertebrate development, epithelial cells establish and maintain apicobasal polarity, failure of which can cause developmental defects or cancer metastasis. This process has been mostly studied in simple epithelia that have only one layer of cells, but is poorly understood in stratified epithelia. In this paper we address the role of the polarity protein Partitioning defective-6 homolog beta (Par6b) in the developing stratified epidermis of Xenopus laevis. At the blastula stage, animal blastomeres divide perpendicularly to the apicobasal axis to generate partially polarized superficial cells and non-polarized deep cells. Both cell populations modify their apicobasal polarity during the gastrula stage, before differentiating into the superficial and deep layers of epidermis. Early differentiation of the epidermis is normal in Par6b-depleted embryos; however, epidermal cells dissociate and detach from embryos at the tailbud stage. Par6b-depleted epidermal cells exhibit a significant reduction in basolaterally localized E-cadherin. Examination of the apical marker Crumbs homolog 3 (Crb3) and the basolateral marker Lethal giant larvae 2 (Lgl2) after Par6b depletion reveals that Par6b cell-autonomously regulates the dynamics of apicobasal polarity in both superficial and deep epidermal layers. Par6b is required to maintain the “basolateral” state in both epidermal layers, which explains the reduction of basolateral adhesion complexes and epidermal cells shedding. PMID:24204686

  4. Etiología en parálisis cerebral.

    Directory of Open Access Journals (Sweden)

    Patricia Campos

    1996-07-01

    Full Text Available Objetivo: Determinar las causas mas frecuentes de parálisis cerebral (PC. Material y métodos: Estudio descriptivo realizado en Hospital Nacional Cayetano Heredia y el Hogar Clínica San Juan de Dios (Lima-Perú, entre noviembre 1990 y mayo de 1992. Se revisaron las historias clínicas de 102 pacientes con diagnósticos de PC y se revisó las etiologías. Resultados: En relación a edad gestacional hubieron 15 casos de prematuros (14.7%, 67(65% a término y un postmaduro, en 19 no se tuvo la edad gestacional. El peso al nacer fue adecuado en 56(54.9%, bajo en 17(16.7% y muy bajo en 7(6.9%. Se identificó la causa de PC en 73/102 casos (70%, siendo las causas más frecuentes las perinatales (59.3%, seguidas de las prenatales con 29.1% y las postnatales con 11.6%. En el grupo de causas prenatales, la mitad fueron malformaciones cerebrales congénitas entre las que destaca el quiste porencefálico, presente en la mitad de estos casos. En el grupo perinatal, la más frecuente fue asfixia (83% asociada o no a otro factor metabólico. Hubieron además en este grupo 4 casos de hipoglicemia severa y 2 con encefalopatía hiperbilirrubinémica y PC distónica. Las causas postnatal más frecuente fue la meningoencefalitis bacteriana, en menores de un año de edad. Al correlacionar etiología y momento del daño, peso al nacer y tipo de PC se observa que, en los recién nacidos PT de bajo o muy bajo peso al nacer es mas frecuente la PC de tipo dipléjica y en todos el antecedente fue asfixia perinatal. Conclusiones: La baja frecuencia de PC dipléjica y la elevada frecuencia de causas perinatales (asfixia, marca nuestra diferencia con otras series y obedece en nuestra opinión, a los escasos recursos tecnológicos y las deficiencias en la atención a las gestantes y recién nacidos de nuestro sistema nacional de salud. (Rev Med Hered 1996; 7: 114-118.

  5. Modeling post-wildfire hydrological processes with ParFlow

    Science.gov (United States)

    Escobar, I. S.; Lopez, S. R.; Kinoshita, A. M.

    2017-12-01

    Wildfires alter the natural processes within a watershed, such as surface runoff, evapotranspiration rates, and subsurface water storage. Post-fire hydrologic models are typically one-dimensional, empirically-based models or two-dimensional, conceptually-based models with lumped parameter distributions. These models are useful for modeling and predictions at the watershed outlet; however, do not provide detailed, distributed hydrologic processes at the point scale within the watershed. This research uses ParFlow, a three-dimensional, distributed hydrologic model to simulate post-fire hydrologic processes by representing the spatial and temporal variability of soil burn severity (via hydrophobicity) and vegetation recovery. Using this approach, we are able to evaluate the change in post-fire water components (surface flow, lateral flow, baseflow, and evapotranspiration). This work builds upon previous field and remote sensing analysis conducted for the 2003 Old Fire Burn in Devil Canyon, located in southern California (USA). This model is initially developed for a hillslope defined by a 500 m by 1000 m lateral extent. The subsurface reaches 12.4 m and is assigned a variable cell thickness to explicitly consider soil burn severity throughout the stages of recovery and vegetation regrowth. We consider four slope and eight hydrophobic layer configurations. Evapotranspiration is used as a proxy for vegetation regrowth and is represented by the satellite-based Simplified Surface Energy Balance (SSEBOP) product. The pre- and post-fire surface runoff, subsurface storage, and surface storage interactions are evaluated at the point scale. Results will be used as a basis for developing and fine-tuning a watershed-scale model. Long-term simulations will advance our understanding of post-fire hydrological partitioning between water balance components and the spatial variability of watershed processes, providing improved guidance for post-fire watershed management. In reference

  6. 194 Évaluation de l'efficacité de l'insecticide Tricel 480 EC ...

    African Journals Online (AJOL)

    PR BOKO

    phytosanitaires par les agriculteurs, induit l'apparition de populations résistantes de ravageurs tel que. Plutellaxylostella [4], des risques sanitaires importants tels que les résidus de pesticides et de nitrates dans les produits alimentaires et les sols [5]. Parmi ces cultures maraichères, le chou fait partie des plus attaquées par ...

  7. Fatores associados à ocorrência de parasitoses intestinais em uma população de crianças e adolescentes Factores asociados a la ocurrencia de parasitosis intestinales en una población de niños y adolescentes Factors associated with intestinal parasitosis in a population of children and adolescents

    Directory of Open Access Journals (Sweden)

    Vinícius Silva Belo

    2012-06-01

    Full Text Available OBJETIVOS: Analisar a prevalência de infecções por parasitos intestinais em crianças e adolescentes matriculados em escolas de ensino fundamental no município de São João del-Rei, Minas Gerais, e os fatores associados à infecção. MÉTODOS: Estudo epidemiológico seccional, realizado entre março/2008 e julho/2009. Foram realizados exames coproscópicos por sedimentação espontânea e Kato-Katz em 1.172 escolares. Foram ajustados modelos de regressão logística múltipla para o estudo dos fatores associados às infecções em geral e, separadamente, por helmintos e por protozoários. RESULTADOS: A prevalência de infecções foi de 29%, havendo uma variação de 7 a 83%, respectivamente, entre as escolas de menor e maior ocorrência. A presença de instalação sanitária no domicílio foi associada a uma ocorrência menor de helmintos; o aumento na idade dos escolares associou-se a uma maior ocorrência de protozoários e de parasitos em geral; enquanto a presença de filtro de água e a localização do domicílio em área urbana mostraram-se associadas a uma ocorrência menor dos três desfechos analisados. Em todas as regiões, foi registrado o consumo de medicação preventiva contra helmintos. CONCLUSÕES: Desigualdades nas condições de vida tornaram as prevalências diferenciadas entre as regiões do estudo. O estudo ressalta a necessidade de promover o uso de filtros de água nas residências de áreas endêmicas e de avaliar o consumo preventivo de medicamentos anti-helmínticos na dinâmica e na saúde dos indivíduos. Medidas de controle que levem em conta os fatores descritos devem ser prioritárias em nível de Saúde Pública.OBJETIVOS: Analizar la prevalencia de infecciones por parasitas intestinales en niños y adolescentes matriculados en escuelas de enseñanza primaria en el municipio de São João del-Rei, Minas Gerais (Brasil, y los factores asociados a la infección. MÉTODOS: Estudio epidemiológico seccional

  8. ALTERACIONES EN LA PRODUCCIÓN mRNA DE ENZIMAS INTESTINALES DE CERDOS DURANTE VARIOS PERÍODOS POSDESTETE ALTERAÇÕES NA PRODUÇÃO DE mRNA DE ENZIMAS INTESTINAIS DOS SUINOS DURANTE DIVERSOS PERÍODOS APOS O DESMAME ALTERATIONS IN THE PRODUCTION mRNA OF INTESTINAL ENZYMES IN PIGS DURING SEVERAL POSTWEANING PERIODS

    Directory of Open Access Journals (Sweden)

    CAROLINA MONTOYA R.

    2012-12-01

    Full Text Available El objetivo de este estudio fue determinar la expresión génica de enzimas a nivel de enterocito de cerdos durante el período posdestete. El trabajo de campo se realizó con 16 cerdos destetados a los 21 días de edad en el Centro San Pablo, perteneciente a la Universidad Nacional de Colombia. Los animales fueron alimentados durante 10 días con una dieta basal que tuvo como componentes leche y algunos de sus derivados, y que además cumplía con todos los mínimos nutricionales. Los cerdos se sacrificaron escalonadamente los días 1, 5, 7 y 10 posdestete. Se realizó extracción completa del intestino delgado, el cual fue dividido en tres secciones (duodeno, yeyuno e íleon. Se evaluó la expresión génica de las enzimas digestivas por RT-PCR. El diseño estadístico empleado fue completamente al azar. Para las enzimas intestinales se presentaron disminuciones significativas, donde el día cinco posdestete presentó los menores valores(PO objetivo desta pesquisa foi determinar a expressão dos genes das aminopeptidases e dissacaridasesaonível do enterocito de suinos durante períodos apos o desmame. A experiência foi conduzida no centro de produção de San Pablo da Universidade Nacional de Colômbia (Medellín com 16 suinos desmamados aos 21 dias de vida. Os animais foram alimentados por 10 diascomuma dieta básica comleite e alguns de seus derivados, e aquele igualmente cumpriu todos os requisitos mínimos nutricionaís. Os suinos foram eutanasiados nos dias 1, 5, 7 y 10 pós-desmame. A extração completa do intestino pequeno foi realizada, que foi dividido emtrêsseções (duodeno, jejum e íleo. A expressão dos genes das enzimas digestivas por RT-PCR foi avaliada. O delineamento estatístico empregado foi completamente ao acaso. Para as enzimas intestinais as diminuições significativas foram apresentadas, onde no quinto diaapos o desmame apresentou os valores mais baixos (P0.01. O desmame precoce altera a expressão molecular das

  9. Delirio omicidiario condiviso nelle coppie di serial killer / Délire homicidaire partagé par les couples de tueurs en série / Shared psychotic disorder in serial killers acting in pair

    Directory of Open Access Journals (Sweden)

    Mastronardi Vincenzo

    2012-10-01

    Full Text Available Les tueurs en série qui agissent en couple sont très rares d’un point de vue statistique. Le plus souvent, entre les deux membres du couple, un délire commun apparaît progressivement, conduisant ces sujets à réitérer ensemble les passages à l’acte homicidaire.Ce cadre clinique prévoit qu’un individu, défini comme dominant et nommé « Inducteur » ou « Cas primaire », influence un individu plus faible, nommé « Induit », en lui imposant son système délirant. Le plus souvent, le membre du couple le plus faible ne provient pas d’une sous-culture criminelle et ne souffre d’aucun trouble psychiatrique qui justifierait son adhésion aux actions de l’individu dominant. Le syndrome a été décrit pour la première fois par Lasègue et Falret à la fin du XIXème siècle et nommé « folie à deux » ; le DSM-IV TR parle de « trouble psychotique partagé ».Les couples de tueurs en série les plus représentés d’un point de vue statistique sont composées de deux hommes, puis par un homme et une femme et, enfin, par deux femmes.Le lien entre les deux membres de ces couples peut être de type amical, sentimental ou de parenté.Bien que le « Cas primaire » soit dominant dans le couple, il ne faut pas négliger la contribution de l’individu faible au délire homicidaire partagé : en effet, sur la base de la logique particulière d’une relation complémentaire pathologique, les deux acteurs jouent un rôle majeur et fonctionnel à la continuité de la relation. Même l’individu apparemment le plus passif et soumis joue un rôle actif dans la formation du délire homicidaire partagé.Serial killers acting in pair represent an event which is statistically very rare. A sort of common delirium gradually structured between the two members of the pair, brings them to reiterate their homicidal actions.This clinical situation provides that a person described as dominant and called “inducer” or “primary” or

  10. ParA-like protein influences the distribution of multi-copy chromosomes in cyanobacterium Synechococcus elongatus PCC 7942.

    Science.gov (United States)

    Watanabe, Satoru; Noda, Aska; Ohbayashi, Ryudo; Uchioke, Kana; Kurihara, Ami; Nakatake, Shizuka; Morioka, Sayumi; Kanesaki, Yu; Chibazakura, Taku; Yoshikawa, Hirofumi

    2018-01-01

    While many bacteria, such as Escherichia coli and Bacillus subtilis, harbour a single-copy chromosome, freshwater cyanobacteria have multiple copies of each chromosome per cell. Although it has been reported that multi-copy chromosomes are evenly distributed along the major axis of the cell in cyanobacterium Synechococcus elongatus PCC 7942, the distribution mechanism of these chromosomes remains unclear. In S. elongatus, the carboxysome, a metabolic microcompartment for carbon fixation that is distributed in a similar manner to the multi-copy chromosomes, is regulated by ParA-like protein (hereafter ParA). To elucidate the role of ParA in the distribution of multi-copy chromosomes, we constructed and analysed ParA disruptant and overexpressing strains of S. elongatus. Our fluorescence in situ hybridization assay revealed that the parA disruptants displayed an aberrant distribution of their multi-copy chromosomes. In the parA disruptant the multiple origin and terminus foci, corresponding to the intracellular position of each chromosomal region, were aggregated, which was compensated by the expression of exogenous ParA from other genomic loci. The parA disruptant is sensitive to UV-C compared to the WT strain. Additionally, giant cells appeared under ParA overexpression at the late stage of growth indicating that excess ParA indirectly inhibits cell division. Screening of the ParA-interacting proteins by yeast two-hybrid analysis revealed four candidates that are involved in DNA repair and cell membrane biogenesis. These results suggest that ParA is involved in the pleiotropic cellular functions with these proteins, while parA is dispensable for cell viability in S. elongatus.

  11. A method for estimating the diffuse attenuation coefficient (KdPAR)from paired temperature sensors

    Science.gov (United States)

    Read, Jordan S.; Rose, Kevin C.; Winslow, Luke A.; Read, Emily K.

    2015-01-01

    A new method for estimating the diffuse attenuation coefficient for photosynthetically active radiation (KdPAR) from paired temperature sensors was derived. We show that during cases where the attenuation of penetrating shortwave solar radiation is the dominant source of temperature changes, time series measurements of water temperatures at multiple depths (z1 and z2) are related to one another by a linear scaling factor (a). KdPAR can then be estimated by the simple equation KdPAR ln(a)/(z2/z1). A suggested workflow is presented that outlines procedures for calculating KdPAR according to this paired temperature sensor (PTS) method. This method is best suited for conditions when radiative temperature gains are large relative to physical noise. These conditions occur frequently on water bodies with low wind and/or high KdPARs but can be used for other types of lakes during time periods of low wind and/or where spatially redundant measurements of temperatures are available. The optimal vertical placement of temperature sensors according to a priori knowledge of KdPAR is also described. This information can be used to inform the design of future sensor deployments using the PTS method or for campaigns where characterizing sub-daily changes in temperatures is important. The PTS method provides a novel method to characterize light attenuation in aquatic ecosystems without expensive radiometric equipment or the user subjectivity inherent in Secchi depth measurements. This method also can enable the estimation of KdPAR at higher frequencies than many manual monitoring programs allow.

  12. Clathrin and LRP-1-independent constitutive endocytosis and recycling of uPAR.

    Directory of Open Access Journals (Sweden)

    Katia Cortese

    Full Text Available BACKGROUND: The urokinase receptor (uPAR/CD87 is highly expressed in malignant tumours. uPAR, as a GPI anchored protein, is preferentially located at the cell surface, where it interacts with its ligands urokinase (uPA and the extracellular matrix protein vitronectin, thus promoting plasmin generation, cell-matrix interactions and intracellular signalling events. Interaction with a complex formed by uPA and its inhibitor PAI-1 induces cell surface down regulation and recycling of the receptor via the clathrin-coated pathway, a process dependent on the association to LRP-1. METHODOLOGY/PRINCIPAL FINDINGS: In this study, we have found that along with the ligand-induced down-regulation, uPAR also internalizes and recycles constitutively through a second pathway that is independent of LRP-1 and clathrin but shares some properties with macropinocytosis. The ligand-independent route is amiloride-sensitive, does not require uPAR partitioning into lipid rafts, is independent of the activity of small GTPases RhoA, Rac1 and Cdc42, and does not require PI3K activity. Constitutively endocytosed uPAR is found in EEA1 positive early/recycling endosomes but does not reach lysosomes in the absence of ligands. Electron microscopy analysis reveals the presence of uPAR in ruffling domains at the cell surface, in macropinosome-like vesicles and in endosomal compartments. CONCLUSIONS/SIGNIFICANCE: These results indicate that, in addition to the ligand-induced endocytosis of uPAR, efficient surface expression and membrane trafficking might also be driven by an uncommon macropinocytic mechanism coupled with rapid recycling to the cell surface.

  13. Evaluation of treatment and posttreatment changes of protraction facemask treatment using the PAR index.

    Science.gov (United States)

    Ngan, P; Yiu, C

    2000-10-01

    The purpose of this study was to use the Peer Assesment Rating (PAR) index score to evaluate the treatment and posttreatment changes of Class III patients treated by protraction facemask. The sample consisted of 20 Chinese children, 6 to 11 years old, with Class III skeletal malocclusion who had been treated with maxillary expansion and a protraction facemask. The average treatment time was 8.2 months, followed by 1 year of retention with a Class III functional appliance. Study casts were taken pretreatment (T1), posttreatment (T2), 1 year follow-up (T3), and 2 years follow-up (T4). After treatment, PAR scores were calculated for each time period. Differences among the 4 time periods were analyzed with the Wilcoxin matched-pairs test. Significant reductions in PAR scores were found at T2 (56%), T3 (70%), and T4 (63%) compared with T1. Immediately posttreatment (T2), 17 (85%) of 20 patients had improved PAR scores by a reduction of at least 30%. Reductions were caused primarily by correction of the anterior crossbite. One year after treatment (T3), further reductions in PAR score were noted (P <.01) as a result of better alignment of the anterior segment, improvement of the buccal occlusion, and overbite and midline corrections. Two years after treatment (T4), PAR scores were higher than at the previous time period. The increases were due to relapses in overjet (4 of 20 patients), overbite, and centerline corrections. These results indicate that significant reductions in the severity of Class III malocclusion can be achieved with early orthopedic facemask treatment. In most cases, further improvement in the PAR score can be expected 1 and 2 years after treatment. In a few patients, the benefits of early treatment are negated by relapses in overjet, overbite, and centerline corrections during the follow-up period.

  14. Lumbar lordosis and pars interarticularis fractures: a case-control study

    International Nuclear Information System (INIS)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P.

    2012-01-01

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  15. Lumbar lordosis and pars interarticularis fractures: a case-control study

    Energy Technology Data Exchange (ETDEWEB)

    Bugg, William G.; Lewis, Mark; Juette, Arne; Cahir, John G.; Toms, Andoni P. [Cotman Centre, Norwich Radiology Academy, Norwich, Norfolk (United Kingdom)

    2012-07-15

    The aim of this study is to examine the relationship between lumbar lordosis and pars interarticularis fractures. In this retrospective case-control study we compare the angle of lumbar lordosis and the angle of the S1 vertebral endplate (as a measure of pelvic tilt) in patients with bilateral L5 pars interarticularis fractures with age- and sex-matched control cases with normal MRI examinations of the lumbar spine. Twenty-nine cases of bilateral L5 pars interarticularis fractures with matched control-cases were identified on MRI (16 male, 13 female, age 9-63 years). The angle of lordosis was measured between the inferior L4 and superior S1 vertebral endplates on a standing lateral lumbar spine radiograph for both groups. The mean angle of lordosis about the L5 vertebra was 36.9 (SD = 6.5 ) in the pars interarticularis fracture group, and 30.1 (SD = 6.4 ) in the control group. The difference between the two groups was significant (mean difference 6.8 , Student's t test: P < 0.001). The mean angle of sacral tilt measured was 122.2 (SD = 10.16 ) for controls and 136.4 (SD = 10.86 ) for patients with pars defects. The difference in the means of 14.2 was statistically significantly different (P < 0.0001). Sacral tilt represented by a steeply angled superior endplate of S1 is associated with a significantly increased angle of lordosis, between L4 and S1, and pars fractures at L5. Steep angulation of the first sacral vertebral segment maybe the predisposing biomechanical factor that leads to pincer-like impingement of the pars interarticularis and then spondylolysis. (orig.)

  16. Identification of a new epitope in uPAR as a target for the cancer therapeutic monoclonal antibody ATN-658, a structural homolog of the uPAR binding integrin CD11b (αM.

    Directory of Open Access Journals (Sweden)

    Xiang Xu

    Full Text Available The urokinase plasminogen activator receptor (uPAR plays a role in tumor progression and has been proposed as a target for the treatment of cancer. We recently described the development of a novel humanized monoclonal antibody that targets uPAR and has anti-tumor activity in multiple xenograft animal tumor models. This antibody, ATN-658, does not inhibit ligand binding (i.e. uPA and vitronectin to uPAR and its mechanism of action remains unclear. As a first step in understanding the anti-tumor activity of ATN-658, we set out to identify the epitope on uPAR to which ATN-658 binds. Guided by comparisons between primate and human uPAR, epitope mapping studies were performed using several orthogonal techniques. Systematic site directed and alanine scanning mutagenesis identified the region of aa 268-275 of uPAR as the epitope for ATN-658. No known function has previously been attributed to this epitope Structural insights into epitope recognition were obtained from structural studies of the Fab fragment of ATN-658 bound to uPAR. The structure shows that the ATN-658 binds to the DIII domain of uPAR, close to the C-terminus of the receptor, corroborating the epitope mapping results. Intriguingly, when bound to uPAR, the complementarity determining region (CDR regions of ATN-658 closely mimic the binding regions of the integrin CD11b (αM, a previously identified uPAR ligand thought to be involved in leukocyte rolling, migration and complement fixation with no known role in tumor progression of solid tumors. These studies reveal a new functional epitope on uPAR involved in tumor progression and demonstrate a previously unrecognized strategy for the therapeutic targeting of uPAR.

  17. L’usage de Twitter par les maires d’Île-de-France

    Directory of Open Access Journals (Sweden)

    Nicolas Douay

    2016-05-01

    Full Text Available Cet article propose de visualiser des données numériques produites par l’usage du réseau social Twitter par les maires de la région Ile-de-France. En effet Twitter est maintenant un outil de communication en pleine expansion et les personnalités publiques l’utilisent abondamment comme un moyen de rejoindre les internautes intéressés par leurs engagements et responsabilités. L’analyse et la visualisation de ces « big data » visent donc à réaliser une étude de l’usage d’un réseau social par des élus locaux. Il s’agit, d’abord, de dresser le profil type des maires présents sur le réseau social en fonction du genre, de l’âge, de l’appartenance partisane, du niveau de responsabilité et du type d’espace. Puis de caractériser les usages quant à l’audience et au rayonnement de l’activité par l’analyse du nombre de tweets et des followers en reprenant les mêmes critères. Et enfin, il s’agit d’observer le contenu des messages échangés et de les analyser comme des illustrations du débat public local.

  18. Valproate alters dopamine signaling in association with induction of Par-4 protein expression.

    Directory of Open Access Journals (Sweden)

    Saebom Lee

    Full Text Available Chromatin remodeling through histone modifications has emerged as a key mechanism in the pathophysiology of psychiatric disorders. Valproate (VPA, a first-line medication for bipolar disorder, is known to have histone deacetylase (HDAC inhibitor activity, but the relationship between its efficacy as a mood stabilizer and HDAC inhibitory activity is unclear. Here we provide evidence that prostate apoptosis response-4 (Par-4, an intracellular binding partner of dopamine D2 receptors (DRD2, plays a role in mediating the effectiveness of VPA. We found that chronic VPA treatment enhanced the expression of Par-4 in cultured neurons and adult mouse brains. This Par-4 induction phenomenon occurred at the transcriptional level and was correlated with an increase in histone H3 and H4 acetylation of the Par-4 promoter regions. Furthermore, chronic VPA treatment potentiated the suppression of the cAMP signaling cascade upon dopamine stimulation, which was blocked by sulpiride treatment. These results indicate that VPA potentiates DRD2 activity by enhancing Par-4 expression via a chromatin remodeling mechanism.

  19. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology.

    Science.gov (United States)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Eugen-Olsen, Jesper; Hwang, Ing-Shouh; Boisen, Anja

    2013-11-08

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody-antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform.

  20. PAR-1 mediated apoptosis of breast cancer cells by V. cholerae hemagglutinin protease.

    Science.gov (United States)

    Ray, Tanusree; Pal, Amit

    2016-05-01

    Bacterial toxins have emerged as promising agents in cancer treatment strategy. Hemagglutinin (HAP) protease secreted by Vibrio cholerae induced apoptosis in breast cancer cells and regresses tumor growth in mice model. The success of novel cancer therapies depends on their selectivity for cancer cells with limited toxicity for normal tissues. Increased expression of Protease Activated Receptor-1 (PAR-1) has been reported in different malignant cells. In this study we report that HAP induced activation and over expression of PAR-1 in breast cancer cells (EAC). Immunoprecipitation studies have shown that HAP specifically binds with PAR-1. HAP mediated activation of PAR-1 caused nuclear translocation of p50-p65 and the phosphorylation of p38 which triggered the activation of NFκB and MAP kinase signaling pathways. These signaling pathways enhanced the cellular ROS level in malignant cells that induced the intrinsic pathway of cell apoptosis. PAR-1 mediated apoptosis by HAP of malignant breast cells without effecting normal healthy cells in the same environment makes it a good therapeutic agent for treatment of cancer.

  1. Nanomechanical recognition of prognostic biomarker suPAR with DVD-ROM optical technology

    International Nuclear Information System (INIS)

    Bache, Michael; Bosco, Filippo G; Brøgger, Anna L; Frøhling, Kasper B; Boisen, Anja; Alstrøm, Tommy Sonne; Hwu, En-Te; Chen, Ching-Hsiu; Hwang, Ing-Shouh; Eugen-Olsen, Jesper

    2013-01-01

    In this work the use of a high-throughput nanomechanical detection system based on a DVD-ROM optical drive and cantilever sensors is presented for the detection of urokinase plasminogen activator receptor inflammatory biomarker (uPAR). Several large scale studies have linked elevated levels of soluble uPAR (suPAR) to infectious diseases, such as HIV, and certain types of cancer. Using hundreds of cantilevers and a DVD-based platform, cantilever deflection response from antibody–antigen recognition is investigated as a function of suPAR concentration. The goal is to provide a cheap and portable detection platform which can carry valuable prognostic information. In order to optimize the cantilever response the antibody immobilization and unspecific binding are initially characterized using quartz crystal microbalance technology. Also, the choice of antibody is explored in order to generate the largest surface stress on the cantilevers, thus increasing the signal. Using optimized experimental conditions the lowest detectable suPAR concentration is currently around 5 nM. The results reveal promising research strategies for the implementation of specific biochemical assays in a portable and high-throughput microsensor-based detection platform. (paper)

  2. Participatory action research (PAR) in middle school: opportunities, constraints, and key processes.

    Science.gov (United States)

    Ozer, Emily J; Ritterman, Miranda L; Wanis, Maggie G

    2010-09-01

    Late childhood and early adolescence represent a critical transition in the developmental and academic trajectory of youth, a time in which there is an upsurge in academic disengagement and psychopathology. PAR projects that can promote youth's sense of meaningful engagement in school and a sense of efficacy and mattering can be particularly powerful given the challenges of this developmental stage. In the present study, we draw on data from our own collaborative implementation of PAR projects in secondary schools to consider two central questions: (1) How do features of middle school settings and the developmental characteristics of the youth promote or inhibit the processes, outcomes, and sustainability of the PAR endeavor? and (2) How can the broad principles and concepts of PAR be effectively translated into specific intervention activities in schools, both within and outside of the classroom? In particular, we discuss a participatory research project conducted with 6th and 7th graders at an urban middle school as a means of highlighting the opportunities, constraints, and lessons learned in our efforts to contribute to the high-quality implementation and evaluation of PAR in diverse urban public schools.

  3. Active zone proteins are transported via distinct mechanisms regulated by Par-1 kinase.

    Directory of Open Access Journals (Sweden)

    Kara R Barber

    2017-02-01

    Full Text Available Disruption of synapses underlies a plethora of neurodevelopmental and neurodegenerative disease. Presynaptic specialization called the active zone plays a critical role in the communication with postsynaptic neuron. While the role of many proteins at the active zones in synaptic communication is relatively well studied, very little is known about how these proteins are transported to the synapses. For example, are there distinct mechanisms for the transport of active zone components or are they all transported in the same transport vesicle? Is active zone protein transport regulated? In this report we show that overexpression of Par-1/MARK kinase, a protein whose misregulation has been implicated in Autism spectrum disorders (ASDs and neurodegenerative disorders, lead to a specific block in the transport of an active zone protein component- Bruchpilot at Drosophila neuromuscular junctions. Consistent with a block in axonal transport, we find a decrease in number of active zones and reduced neurotransmission in flies overexpressing Par-1 kinase. Interestingly, we find that Par-1 acts independently of Tau-one of the most well studied substrates of Par-1, revealing a presynaptic function for Par-1 that is independent of Tau. Thus, our study strongly suggests that there are distinct mechanisms that transport components of active zones and that they are tightly regulated.

  4. MARK/Par1 Kinase Is Activated Downstream of NMDA Receptors through a PKA-Dependent Mechanism.

    Directory of Open Access Journals (Sweden)

    Laura P Bernard

    Full Text Available The Par1 kinases, also known as microtubule affinity-regulating kinases (MARKs, are important for the establishment of cell polarity from worms to mammals. Dysregulation of these kinases has been implicated in autism, Alzheimer's disease and cancer. Despite their important function in health and disease, it has been unclear how the activity of MARK/Par1 is regulated by signals from cell surface receptors. Here we show that MARK/Par1 is activated downstream of NMDA receptors in primary hippocampal neurons. Further, we show that this activation is dependent on protein kinase A (PKA, through the phosphorylation of Ser431 of Par4/LKB1, the major upstream kinase of MARK/Par1. Together, our data reveal a novel mechanism by which MARK/Par1 is activated at the neuronal synapse.

  5. Intérêt de la thérapie antivirale par voie orale dans le traitement des ...

    African Journals Online (AJOL)

    Chez les patients immunodéprimés, les complications de l'ARN syndrome conduisent souvent à une perte d'acuité visuelle. La confirmation de ce diagnostic dès la découverte de la maladie par la réaction de polymérase en chaîne (PCR) et par le coefficient de charge immunitaire (CCI) le plus souvent par ponction ...

  6. Ataque de viento externo con manifestaciones de parálisis facial periférica tratado con acupuntura

    OpenAIRE

    Pinzón Ramírez, Betty Alejandra

    2012-01-01

    El ataque de viento externo es considerado desde la medicina china como un síndrome patológico que puede cursar con manifestaciones de parálisis facial semejante a la parálisis de Bell o parálisis facial idiopática de la medicina occidental, la cual también es efectivamente tratada con acupuntura; sin embargo en la actualidad no hay estudios al respecto en nuestra población. El objetivo es describir las características de población, presentación y evolución de la parálisis facial asociada ...

  7. Tumour microenvironments induce expression of urokinase plasminogen activator receptor (uPAR and concomitant activation of gelatinolytic enzymes.

    Directory of Open Access Journals (Sweden)

    Synnøve Magnussen

    Full Text Available The urokinase plasminogen activator receptor (uPAR is associated with poor prognosis in oral squamous cell carcinoma (OSCC, and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells' expression level of uPAR affected the activity of gelatinolytic enzymes.The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography.We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes.Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the regulation of posttranslational

  8. Transmission and Distribution of Photosynthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7226-270], Phase II

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  9. Transmission and Distribution of Photosymthetically Active Radiation (PAR) for Biomass Production in Exploration Missions [7216-050], Phase I

    Data.gov (United States)

    National Aeronautics and Space Administration — Physical Sciences Inc. (PSI) proposes to develop a plant lighting system which collects, transmits and distributes photosynthetically active radiation (PAR) for...

  10. Tumour Microenvironments Induce Expression of Urokinase Plasminogen Activator Receptor (uPAR) and Concomitant Activation of Gelatinolytic Enzymes

    Science.gov (United States)

    Magnussen, Synnøve; Hadler-Olsen, Elin; Latysheva, Nadezhda; Pirila, Emma; Steigen, Sonja E.; Hanes, Robert; Salo, Tuula; Winberg, Jan-Olof; Uhlin-Hansen, Lars; Svineng, Gunbjørg

    2014-01-01

    Background The urokinase plasminogen activator receptor (uPAR) is associated with poor prognosis in oral squamous cell carcinoma (OSCC), and increased expression of uPAR is often found at the invasive tumour front. The aim of the current study was to elucidate the role of uPAR in invasion and metastasis of OSCC, and the effects of various tumour microenvironments in these processes. Furthermore, we wanted to study whether the cells’ expression level of uPAR affected the activity of gelatinolytic enzymes. Methods The Plaur gene was both overexpressed and knocked-down in the murine OSCC cell line AT84. Tongue and skin tumours were established in syngeneic mice, and cells were also studied in an ex vivo leiomyoma invasion model. Soluble factors derived from leiomyoma tissue, as well as purified extracellular matrix (ECM) proteins, were assessed for their ability to affect uPAR expression, glycosylation and cleavage. Activity of gelatinolytic enzymes in the tissues were assessed by in situ zymography. Results We found that increased levels of uPAR did not induce tumour invasion or metastasis. However, cells expressing low endogenous levels of uPAR in vitro up-regulated uPAR expression both in tongue, skin and leiomyoma tissue. Various ECM proteins had no effect on uPAR expression, while soluble factors originating from the leiomyoma tissue increased both the expression and glycosylation of uPAR, and possibly also affected the proteolytic processing of uPAR. Tumours with high levels of uPAR, as well as cells invading leiomyoma tissue with up-regulated uPAR expression, all displayed enhanced activity of gelatinolytic enzymes. Conclusions Although high levels of uPAR are not sufficient to induce invasion and metastasis, the activity of gelatinolytic enzymes was increased. Furthermore, several tumour microenvironments have the capacity to induce up-regulation of uPAR expression, and soluble factors in the tumour microenvironment may have an important role in the

  11. Rational targeting of the urokinase receptor (uPAR): development of antagonists and non-invasive imaging probes

    DEFF Research Database (Denmark)

    Kriegbaum, M C; Persson, M; Haldager, L

    2011-01-01

    -ray crystallography and surface plasmon resonance studies. Importantly, these structural studies also define possible druggable target sites in uPAR for small molecules and provide guidelines for the development of reporter groups applicable for non-invasive molecular imaging of uPAR expression in vivo by positron...... emission tomography. In this review, we will discuss recent advances in our perception of the structure-function relationships of uPAR ligation and how these may assist translational research in preclinical intervention studies of uPAR function....

  12. A mechanism for ParB-dependent waves of ParA, a protein related to DNA segregation during cell division in prokaryotes

    DEFF Research Database (Denmark)

    Hunding, Axel; Gerdes, Kenn; Charbon, Gitte Ebersbach

    2003-01-01

    Prokaryotic plasmids encode partitioning (par) loci involved in segregation of DNA to daughter cells at cell division. A functional fusion protein consisting of Walker-type ParA ATPase and green fluorescent protein (Gfp) oscillates back and forth within nucleoid regions with a wave period of about...... in an autocatalytic process. We discuss this mechanism in relation to recent models for MinDE oscillations in E.coli and to microtubule degradation in mitosis. The study points to an ancestral role for the presented pattern types in generating bipolarity in prokaryotes and eukaryotes....... formation, based on Turing's mechanism, and these patterns are destroyed by the degradation products, only to initiate a new pattern at the opposite nucleoid region. A recurrent wave thus emerges. This may be a particular example of a more general class of pattern forming mechanisms, based on protein...

  13. Helicophyllaceae (Bryophyta, nova ocorrência para o Estado do Pará, Brasil Helicophyllaceae (Bryophyta, a new record to Pará State, Brazil

    Directory of Open Access Journals (Sweden)

    Regina C. L. Lisboa

    2005-09-01

    Full Text Available Helicophyllaceae, família monotípica neotropical, é registrada pela primeira vez no Estado do Pará. Sua única espécie, Helicophyllum torquatum (Hook. Brid., registrada anteriormente no Estado do Amazonas e que recentemente havia sido excluída da lista de musgos amazônicos, é apresentada como nova ocorrência para toda a Amazônia brasileira.Helicophyllaceae, a monotypic family of Neotropics, is presented for the Pará State. Helicophyllum torquatum (Hook. Brid., the single species, was recorded for the Amazonas State, but recently was excluded of checklist of Amazonian mosses. H. torquatum is considered a new report for all Brazilian Amazônia.

  14. Toxina botulínica y fisioterapia en la parálisis cerebral infantil

    OpenAIRE

    Camilieri Rumbau, María Mercé

    2006-01-01

    Introducción: La parálisis cerebral es la causa más común de espasticidad en niños y la toxina botulínica A es un opción para su el tratamiento, ya que produce una parálisis local al ser inyectada en un músculo. Objetivo: Comprobar la eficacia de la aplicación de toxina botulínica y fisioterapia en la parálisis cerebral infantil. Material y método: Se ha realizado una búsqueda en diversas bases de datos electrónicas como son Freejournals, Doyma, Medline, Google y revistas de neuro...

  15. Evaluation of Passive Autocatalytic Recombiner (PAR) Implementation in a Konvoi NPP Containment Type

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Alonso, E.; Papini, D.; Jimenez, G.

    2015-07-01

    The evaluation of Passive Autocatalytic Recombiner (PAR) implementation has been developed under the methodology extracted from the IAEA document, analysing the size, location and number of the PARs capable to minimize the combustion risk, which arises from a hydrogen release generated during a severe accident and its distribution in containment building. A detailed three-dimensional model of Konvoi (PWR) containment with GOTHIC 8.1 code was used for the simulations. The hydrogen preferential pathways and the accumulation points were studied and identified on the basis of a base case scenario without any mitigation measure. The PAR configuration offers an improvement in the chosen accidental scenario; decreasing the possibility of hydrogen combustion and leading to concentration values below the flammability limit (hydrogen concentration below 7%), in all the containment compartments at the end of the transient. Furthermore, from the analysis, it is concluded that the time required to reach hydrogen concentrations below the combustion limit is considerably reduced. (Author)

  16. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    International Nuclear Information System (INIS)

    Paller, M.H.; Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects

  17. Targeting of peptide conjugated magnetic nanoparticles to urokinase plasminogen activator receptor (uPAR) expressing cells

    DEFF Research Database (Denmark)

    Hansen, Line; Larsen, Esben Kjær Unmack; Nielsen, Erik Holm

    2013-01-01

    Ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles are currently being used as a magnetic resonance imaging (MRI) contrast agent in vivo, mainly by their passive accumulation in tissues of interest. However, a higher specificity can ideally be achieved when the nanoparticles are targeted...... towards cell specific receptors and this may also facilitate specific drug delivery by an enhanced target-mediated endocytosis. We report efficient peptide-mediated targeting of magnetic nanoparticles to cells expressing the urokinase plasminogen activator receptor (uPAR), a surface biomarker for poor...... patient prognosis shared by several cancers including breast, colorectal, and gastric cancers. Conjugation of a uPAR specific targeting peptide onto polyethylene glycol (PEG) coated USPIO nanoparticles by click chemistry resulted in a five times higher uptake in vitro in a uPAR positive cell line compared...

  18. Bufo & Spallanzani e a paródia pós-modernista

    Directory of Open Access Journals (Sweden)

    Saulo Brandão

    2016-02-01

    Full Text Available O presente trabalho tem por objetivo investigar as considerações acerca da paródia e sua implicação na linha teórica pós-modernista, partindo das análises de Fredric Jameson e Linda Hutcheon, quando conceituando pastiche. Desse modo, nos propomos a fazer uma análise das paródias no romance Bufo & Spallanzani, de Rubem Fonseca, a partir da leitura de Ana Cristina T. de B. Carvalho (2013 que corrobora para sonegar a proposta de Jameson. Desse modo, procuraremos, no emaranhado de citações do romance, que remetem aos mais diversos campos da cultura, elementos que qualifiquem a característica paródica do romance, tendo por embasamento a contraproposta feita por Linda Hutcheon.

  19. Excrétion de carbone organique par le phytoplancton lémanique

    OpenAIRE

    Feuillade, M.; Dufour, Philippe; Feuillade, J.; Pelletier, J.P.

    1986-01-01

    L'excrétion du carbone organique dissous par le phytoplancton du lac Léman a été évaluée par la méthode du 14C entre mars et novembre 1984. Elle varie entre 0,01 et 0,5 mgC.m-3.h-1 et dépend en premier lieu de la vitesse d'assimilation photosynthétique. L'excrétion carbonée oscille généralement entre 2 et 5% de l'assimilation carbonée et n'excède qu'exceptionnellement 6%. Les valeurs sont sous-estimées par la réassimilation hétérotrophe. L'excrétion nocturne représente moins de 10% des pertes...

  20. Potential Ecological Effects of Contaminants in the Exposed Par Pond Sediments

    Energy Technology Data Exchange (ETDEWEB)

    Paller, M.H. [Westinghouse Savannah River Company, AIKEN, SC (United States); Wike, L.D.

    1996-08-01

    Sediment and small mammal samples were collected from the exposed sediments of Par Pond in early 1995, shortly before the reservoir was refilled after a 4-year drawdown. Sampling was confined to elevations between 58 and 61 meters (190 and 200 feet) above mean sea level, which includes the sediments likely to be exposed if the Par Pond water level is permitted to fluctuate naturally. Both soil and small mammal samples were analyzed for a number of radionuclides and metals. Some of the soil samples were also analyzed for organic contaminants. The objective of the study was to determine if contaminant levels in the Par Pond sediments were high enough to cause deleterious ecological effects.

  1. Accouchement par césarienne et mortalité maternelle du postpartum

    OpenAIRE

    Deneux-Tharaux , Catherine; Carmona , Elodie; Bouvier-Colle , Marie-Hélène; Bréart , Gérard

    2006-01-01

    Objectifs Une augmentation continue du taux d'accouchements par césarienne (CS)est observée dans la plupart des pays depuis 20 ans. Cette évolution a suscité l'émergence d'un débat controversé sur les risques et les bénéfices associés à la CS. L'objectif de cette étude était d'estimer le risque de mort maternelle du postpartum lié directement à la CS par comparaison à l'accouchement par voie basse, globalement et en distinguant les CS pre- ou intra- partum . Méthode Etude cas/témoins. Les cas...

  2. Harmonization and development of resources and tools for Italian natural language processing within the PARLI project

    CERN Document Server

    Bosco, Cristina; Delmonte, Rodolfo; Moschitti, Alessandro; Simi, Maria

    2015-01-01

    The papers collected in this volume are selected as a sample of the progress in Natural Language Processing (NLP) performed within the Italian NLP community and especially attested by the PARLI project. PARLI (Portale per l’Accesso alle Risorse in Lingua Italiana) is a project partially funded by the Ministero Italiano per l’Università e la Ricerca (PRIN 2008) from 2008 to 2012 for monitoring and fostering the harmonic growth and coordination of the activities of Italian NLP. It was proposed by various teams of researchers working in Italian universities and research institutions. According to the spirit of the PARLI project, most of the resources and tools created within the project and here described are freely distributed and they did not terminate their life at the end of the project itself, hoping they could be a key factor in future development of computational linguistics.

  3. Relación entre la Deseabilidad Social y los parámetros del Modelo Logístico de tres parámetros

    Directory of Open Access Journals (Sweden)

    Facundo Abal

    2015-05-01

    Full Text Available El objetivo de este trabajo es estudiar la relación de los parámetros a , b y c del modelo logístico de tres parámetros y la tendencia de los individuos a atribuirse a sí mismo cualidades socialmente deseables. Participaron 1592 personas que respondieron las escalas Perseverancia y Distorsión del Big Five Questionnaire (BFQ. Se aplicó el ML3p a los ítems de perseverancia mediante el programa MULTILOG. Previamente se debieron eliminar 3 reactivos para cumplir con la condición de unidimensionalidad requerida por el modelo. Como la escala Likert de los ítems de perseverancia tiene 5 de alternativas se contemplaron diferentes procedimientos para establecer 4 condiciones de dicotomización de los datos. Los parámetros de los ítems se estimaron el procedimiento de Máxima Verosimilitud Marginal a Posteriori. El ajuste del ML3p fue adecuado para los 9 ítems analizados. Considerando las diferentes condiciones de dicotomización se identificaron entre 3 y 5 ítems de cuya respuesta clave se asoció a mayores niveles de Distorsión. Sin embargo, los resultados obtenidos no permiten concluir que la respuesta influida por la deseabilidad social repercuta sobre alguno de los parámetros estudiados. Se discuten las limitaciones del presente estudio y se comentan otras líneas de investigación que pueden guiar a futuros estudios.

  4. Comparison of Direct Pars Repair Techniques of Spondylolysis in Pediatric and Adolescent Patients: Pars Compression Screw Versus Pedicle Screw-Rod-Hook.

    Science.gov (United States)

    Karatas, Ali F; Dede, Ozgur; Atanda, Alfred A; Holmes, Larry; Rogers, Kenneth; Gabos, Peter; Shah, Suken A

    2016-08-01

    Retrospective clinical cohort study. To compare the clinical and radiographic outcomes of patients who were treated with intrasegmental pars fixation by either laminar compression screw (LS) or a pedicle screw, rod, and laminar hook (PSRH) construct. Spondylolysis is a nonunion defect of the pars interarticularis. In symptomatic spondylolysis, direct repair of the pars interarticularis defect can preserve motion and prevent abnormal stresses at the adjacent levels. Sixteen patients who failed nonoperative treatment and underwent direct pars repair by using LS (n=9) or PSRH (n=7) constructs were included in the study. Clinical outcome was assessed by using the MacNab criteria. Radiologic fusion and complications were evaluated using plain radiographs or computed tomography images and patient charts. The healing rate was 100% after 6 months. The healing time was similar in both the groups: LS, 6.5 months; PSRH, 6.2 months. Patients with PSRH (5.9 mo) were more likely to return to sports earlier relative to patients with LS (7.7 mo). There were no complications in the LS group; in the PSRH group, 1 patient had mild sensory deficit and 2 had superficial wound infections. The MacNab criteria for pain assessment showed an excellent or good outcome in 8 of 9 patients in LS group and 6 of 7 patients in PSRH group. Relative to LS patients, there was a significant increase in surgical time and estimated blood loss among PSRH patients. Either of the mentioned 2 techniques appears to produce acceptable results. Biplanar fluoroscopy and navigation systems could minimize the risk of screw misplacement with LS construct. Familiarity with the various fixation techniques will allow the surgeon to select the most appropriate surgical technique.

  5. First-in-human uPAR PET: Imaging of Cancer Aggressiveness

    Science.gov (United States)

    Persson, Morten; Skovgaard, Dorthe; Brandt-Larsen, Malene; Christensen, Camilla; Madsen, Jacob; Nielsen, Carsten H.; Thurison, Tine; Klausen, Thomas Levin; Holm, Søren; Loft, Annika; Berthelsen, Anne Kiil; Ploug, Michael; Pappot, Helle; Brasso, Klaus; Kroman, Niels; Højgaard, Liselotte; Kjaer, Andreas

    2015-01-01

    A first-in-human clinical trial with Positron Emission Tomography (PET) imaging of the urokinase-type plasminogen activator receptor (uPAR) in patients with breast, prostate and bladder cancer, is described. uPAR is expressed in many types of human cancers and the expression is predictive of invasion, metastasis and indicates poor prognosis. uPAR PET imaging therefore holds promise to be a new and innovative method for improved cancer diagnosis, staging and individual risk stratification. The uPAR specific peptide AE105 was conjugated to the macrocyclic chelator DOTA and labeled with 64Cu for targeted molecular imaging with PET. The safety, pharmacokinetic, biodistribution profile and radiation dosimetry after a single intravenous dose of 64Cu-DOTA-AE105 were assessed by serial PET and computed tomography (CT) in 4 prostate, 3 breast and 3 bladder cancer patients. Safety assessment with laboratory blood screening tests was performed before and after PET ligand injection. In a subgroup of the patients, the in vivo stability of our targeted PET ligand was determined in collected blood and urine. No adverse or clinically detectable side effects in any of the 10 patients were found. The ligand exhibited good in vivo stability and fast clearance from plasma and tissue compartments by renal excretion. In addition, high uptake in both primary tumor lesions and lymph node metastases was seen and paralleled high uPAR expression in excised tumor tissue. Overall, this first-in-human study therefore provides promising evidence for safe use of 64Cu-DOTA-AE105 for uPAR PET imaging in cancer patients. PMID:26516369

  6. Suppression of Arterial Thrombosis without Affecting Hemostatic Parameters with A Cell-Penetrating PAR1 Pepducin

    Science.gov (United States)

    Zhang, Ping; Gruber, András; Kasuda, Shogo; Kimmelstiel, Carey; O’Callaghan, Katie; Cox, Daniel H.; Bohm, Andrew; Baleja, James D.; Covic, Lidija; Kuliopulos, Athan

    2012-01-01

    Background Thrombin-dependent platelet activation is heightened in the setting of percutaneous coronary intervention (PCI) and may cause arterial thrombosis with consequent myocardial necrosis. Given the high incidence of adverse effects in patients with acute coronary syndromes (ACS), there remains an unmet need for the development of new therapeutics that target platelet activation without unduly affecting hemostasis. The thrombin receptor, PAR1, has recently emerged as a promising new target for therapeutic intervention in ACS patients. Methods and Results We report the development of a first-in-class intracellular PAR1 inhibitor with optimized pharmacokinetic properties for use during PCI in ACS patients. PZ-128 is a cell-penetrating ‘pepducin’ inhibitor of PAR1 which targets the receptor-G protein interface on the inside surface of platelets. The structure of PZ-128 closely resembles the predicted off-state of the corresponding juxtamembrane region of the third intracellular loop of PAR1. The onset of action of PZ-128 was rapid and suppressed PAR1 aggregation and arterial thrombosis in guinea pigs and baboons and strongly synergized with oral clopidogrel. There was full recovery of platelet function by 24 h. Importantly, PZ-128 had no effect on bleeding or coagulation parameters in primates or in blood from PCI patients. Conclusions Based on the efficacy data in non-human primates with no noted adverse effects on hemostasis, we anticipate that the rapid onset of platelet inhibition and reversible properties of PZ-128 are well suited to the acute interventional setting of PCI and may provide an alternative to long-acting small molecule inhibitors of PAR1. PMID:22705889

  7. Protease activated receptors (PARS) mediation in gyroxin biological activity; Mediacao dos receptores ativados por proteases (PARs) em atividades biologicas da giroxina

    Energy Technology Data Exchange (ETDEWEB)

    Silva, Jose Alberto Alves da

    2009-07-01

    Gyroxin is a serine protease enzyme from the South American rattlesnake (Crotalus durissus terrificus) venom; it is only partially characterized and has multiple activities. Gyroxin induces blood coagulation, blood pressure decrease and a neurotoxic behavior named barrel rotation. The mechanisms involved in this neurotoxic activity are not known. Whereas gyroxin is a member of enzymes with high potential to become a new drug with clinical applications such as thrombin, batroxobin, ancrod, tripsyn and kalicrein, it is important to find out how gyroxin works. The analysis on agarose gel electrophoresis and circular dichroism confirmed the molecules' integrity and purity. The gyroxin intravenous administration in mice proved its neurotoxicity (barrel rotation). In vivo studies employing intravital microscopy proved that gyroxin induces vasodilation with the participation of protease activated receptors (PARs), nitric oxide and Na+K+ATPase. The leukocytes' adherence and rolling counting indicated that gyroxin has no pro inflammatory activity. Gyroxin induced platelet aggregation, which was blocked by inhibitors of PAR1 and PAR4 receptors (SCH 79797 and tcY-NH{sub 2}, respectively). Finally, it was proved that the gyroxin temporarily alter the permeability of the blood brain barrier (BBB). Our study has shown that both the protease-activated receptors and nitric oxide are mediators involved in the biological activities of gyroxin. (author)

  8. Projekts Parādu piedziņas kompānijas SIA "Parāds" dibināšana

    OpenAIRE

    Poļakovs, Deniss

    2011-01-01

    Pašlaik Latvijas Republikas ekonomika ir uz atgūšanas ceļa, taču, krīzes laikā, izsniegto kredītu apjomi un pakalpojumi ar pēcapmaksu, ir kļuvuši par apgrūtinājumu daudziem uzņēmumiem un fiziskam personām, līdz ar to, arvien aktuālāks kļūst jautājums par parādu atgūšanu. Tas rada situāciju, kad uzņēmumam ir jāpieņem lēmums, vai šīs lietas uzņemties pašam, vai uzticēt piedziņu profesionālām kompānijām, kas ar to nodarbojas. Pacta sunt servanda!" jeb "Līgumi jāpilda!" – tā formulēts viens no...

  9. Nanostructures originales obtenues par décomposition catalytique d'hydrocarbure

    OpenAIRE

    Amamra , M.C.; Lihrmann , J.-M.; Thorel , Alain

    2010-01-01

    National audience; L'arc électrique et la décomposition catalytique d'hydrocarbures peuvent produire diverses nanostructures de carbone, telles que fullerènes, nanotubes, nanofibres et autres particules nanométriques de carbone. Une publication récente1 décrit la préparation et la séparation de nanobâtonnets de carbone dans la suie produite par arc électrique. Ici nous présentons la fabrication de nanobâtonnets de carbone par décomposition catalytique d'hydrocarbures, ainsi que des fibrilles ...

  10. Essai de discrimination du tissu urbain par segmentation d'image

    Directory of Open Access Journals (Sweden)

    Bénédicte COLLETTE

    1991-12-01

    Full Text Available La segmentation est une technique qui, appliquée à l’imagerie satellitaire, permet une détermination zonale des affectations, plutôt que la traditionnelle classification pixel par pixel. Cette détermination zonale correspond davantage aux informations utiles, en urbanisme par exemple. C’est dans cette optique que la méthodologie a été appliquée à l’image d’Aix-la-Chapelle (Aachen, pour y discerner différents types d’urbanisation, selon la densité ou la période d’édification.

  11. Calidad y parálisis del sueño en estudiantes de medicina

    OpenAIRE

    Huamaní, Charles; Reyes, Arturo; Mayta-Tristán, Percy; Timana, Raúl; Salazar, Abel; Sánchez, David; Pérez, Hugo

    2013-01-01

    Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina....

  12. Calidad y parálisis del sueño en estudiantes de medicina

    OpenAIRE

    Charles Huamaní; Arturo Reyes; Percy Mayta-Tristán; Raúl Timana; Abel Salazar; David Sánchez; Hugo Pérez

    2006-01-01

    Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina....

  13. Calidad y parálisis del sueño en estudiantes de medicina

    Directory of Open Access Journals (Sweden)

    Charles Huamaní

    2006-10-01

    Full Text Available Introducción: La parálisis del sueño es un evento de inmovilización corporal estando consciente, ocurre espontáneamente o secundaria a situaciones estresantes o una posible mala calidad de sueño. Objetivo: Determinar la asociación y riesgo de tener parálisis del sueño en los estudiantes de la facultad de medicina, que son malos dormidores. Diseño: Estudio analítico, transversal. Lugar: Facultad de Medicina de la Universidad Nacional Mayor de San Marcos. Participantes: Estudiantes de medicina. Intervenciones: En mayo de 2006, se realizó una muestra no probabilística de estudiantes, por medio de una encuesta que incluía el índice de calidad de sueño de Pittsburg y preguntas sobre parálisis del sueño. Se determinó la asociación entre las variables parálisis del sueño y calidad del sueño y el riesgo (OR de parálisis del sueño en malos dormidores. Se empleó las pruebas de chi cuadrado para las variables cualitativas y t de student para las cuantitativas, con un 95% de confiabilidad. Principales medidas de resultados: Experiencias de parálisis del sueño y prevalencia de malos dormidores. Resultados: El promedio de edad fue 22,3+2,7 años; el 55,5% fue mujer. Las experiencias de parálisis del sueño informadas durante el último mes ocurrieron en 26,6% (21,6 a 32,1% y la prevalencia de malos dormidores fue 48,5% (42,6 a 54,3%. No existió asociación entre ellas (x 2 , p = 0,1; OR = 1,54; IC95: 0,9 a 2,6. Conclusiones: No se halla asociación entre la presentación de parálisis del sueño y una mala calidad de sueño, difiriendo ello con diversos estudios previos, por lo que se sugiere indagar sobre otros factores que pudiesen desencadenarla.

  14. evaluation de la fertilite femelle des arabusta par le niveau de ...

    African Journals Online (AJOL)

    Les hybrides Arabusta sont caractérisés par une faible fertilité exprimée par des taux de caracolis élevés et des taux de loges vides importants induisant des productivités faibles. Pour une stratégie plus efficiente des sélections, il est important de connaître les niveaux de fertilité femelle des différents types de caféiers ...

  15. Parásitos de Fasciola hepática intracoledociano

    OpenAIRE

    MILLÁN A,MARCELO; WAGENKNECHT S,RAUL; CARDENAS P,ALEX; CARRASCO L,CRISTIAN

    2008-01-01

    La fasciolasis es una enfermedad parasitaria producida por el tremátodo digeneo Fasciola hepática. Durante la fase crónica de la enfermedad los parásitos pueden entran en los conductos biliares, y ser causa de ictericia obstructiva, colangitis, pancreatitis y otras complicaciones. Se presenta el caso clínico de una paciente intervenida por sospecha de colelitiasis y colédocolitiasis, a la cual durante la exploración coledociana intraoperatoria le fueron extraídos múltiples parásitos adultos d...

  16. Optimización de una cadena de suministros hospitalarios incorporando parámetros difusos

    OpenAIRE

    Kees, María Celeste; Cragno, María Constanza; Moreno, Marta Susana; Bandoni, Alberto

    2016-01-01

    El propósito de este trabajo es determinar la estructura óptima de una cadena de suministro de insumos hospitalarios. Para ello se plantea un modelo mixto entero lineal determinístico cuyos objetivos de optimización son tanto la minimización de los costos generales como la minimización de los tiempos de envío. Debido a la presencia de incertidumbre en algunos parámetros del problema, se presenta una segunda formulación multiobjetivo en la que se incorporan parámetros difusos a través de una m...

  17. Nature des dommages causés par les piqûres alimentaires des ...

    African Journals Online (AJOL)

    Ces piqûres ont provoqué des nécroses sur les pétales et les étamines qui ont été totalement ou partiellement détruites. Ces dommages ont développé sur les boutons floraux le phénomène d'abscission. Par contre, sur les jeunes capsules infestées, les résultats ont montré que les dégâts causés par H. schoutedeni ont été ...

  18. Neuropathie optique bilatérale par intoxication aigue au méthanol ...

    African Journals Online (AJOL)

    La consommation d'alcool frelaté, contenant du méthanol, est un phénomène de société au Cameroun. Nous rapportons deux cas d'intoxication cécitante au méthanol dont l'évolution a été marquée pour l'un par l'installation d'une cécité irréversible et pour l'autre par une récupération partielle de l'acuité visuelle. Ces cas ...

  19. Prise en charge des péritonites par perforation d'ulcères gastro ...

    African Journals Online (AJOL)

    Le but de cette étude a été de décrire la prise en charge des péritonites aiguës généralisées par perforation d'ulcère gastrique ou duodénal et d'évaluer le bénéfice du drainage abdominal. Nous avons réalisé une étude transversale sur 3 ans. Elle a inclus 129 patients opérés pour péritonites par perforation gastrique ou ...

  20. Flora das cangas da Serra dos Carajás, Pará, Brasil: Caryocaraceae

    OpenAIRE

    Nunes, Clebiana de Sá; Gil, André dos Santos Bragança

    2016-01-01

    Resumo Foi encontrada uma única espécie de Caryocaraceae nas cangas da Serra dos Carajás, Pará, Brasil: Caryocar villosum. É fornecida uma descrição morfológica, prancha ilustrativa, além de comentários taxonômicos, distribuição geográfica e habitat da espécie. Abstract Only one species of Caryocaraceae was found in the canga formations of the Serra dos Carajás, Pará state, Brazil: Caryocar villosum. A morphological description, illustration, geographical distribution and habitat of this s...

  1. Densité, morphologie urbaine et qualité de vie. Une approche par le projet

    OpenAIRE

    Occhiuto, Rita; Goossens, Marc; Fisher, Axel

    2013-01-01

    La recherche "Densification des tissus urbanisés en Wallonie: forme, acceptabilité et modalités pour accompagner la mutation des tissus bâtis" s'articule en plusieurs volets thématiques, parmi lesquels figure le volet "formes urbaines, modes d'habitat". Ce dernier volet est abordé selon deux approches parallèles et complémentaires qui se valident mutuellement: la première dite "par le projet" (approche qualitative et opérationnelle) et la seconde par analyse statistique et cartographique (ap...

  2. Flora das cangas da Serra dos Carajás, Pará, Brasil: Sapotaceae

    OpenAIRE

    Terra-Araujo, Mário Henrique; Zappi, Daniela Cristina

    2018-01-01

    Resumo Uma única espécie de Sapotaceae, Chrysophylloideae, Pouteria ramiflora, ocorre sobre canga na Serra dos Carajás, estado do Pará, Brasil. Este trabalho apresentada uma descrição detalhada, fotografias e comentários morfológicos sobre esta espécie. Abstract A single species of Sapotaceae, Chrysophylloideae, Pouteria ramiflora, occurs on iron-stone (canga) at the Serra dos Carajás, Pará, Brazil. This paper presents a detailed description, photographs and comments regarding this species...

  3. Equações de chuvas intensas para o estado do Pará Intense rainfall equations for the state of Pará, Brazil

    Directory of Open Access Journals (Sweden)

    Rodrigo O. R. de M. Souza

    2012-09-01

    Full Text Available As equações de chuvas intensas têm sido usadas como ferramenta importante para o dimensionamento de obras hidráulicas. Devido à grande carência de informações relativas às equações de chuvas intensas, o presente trabalho teve como objetivo a obtenção das relações de intensidade, duração e frequência de precipitação pluvial para o Estado do Pará, utilizando-se a metodologia da desagregação da chuva de 24 h. Foram utilizadas séries históricas de dados pluviométricos de 74 cidades do Estado do Pará, obtidas no Sistema de Informações Hidrológicas da Agência Nacional de Águas-ANA. As equações de intensidade-duração-frequência foram devidamente ajustadas e apresentaram bom ajuste, com coeficientes de determinação acima de 0,99. A maioria das estações (51,4% apresentou intensidade de precipitação entre 90 e 110 mm h-1, para uma duração de chuva de 30 min e um tempo de retorno de 15 anos. Pode-se perceber uma concentração das maiores precipitações na região próxima ao litoral do nordeste paraense e no sudeste da Ilha do Marajó.The intense rainfall equations have been used as an important tool for design of hydraulic structures. Considering the lack of intense rainfall equations, this study aimed to determine the relations of intensity, duration and frequency of intense rainfall in the Pará State (Brazil, using the one-day rain disaggregation method. In this research rainfall data of 74 cities in the State of Pará were used, obtained from the Hydrological Information System of the National Water Agency-ANA. The equations of intensity-duration-frequency were adjusted and presented good adjustment with coefficients of determination above 0.99. Most stations (51.4% showed intensity of precipitation between 90 and 110 mm h-1 for duration of 30 min and rainfall return period of 15 years. The highest rainfall intensities were in the region near the northeast coast of Pará State and southeast of the Marajo

  4. Experimental study about the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin

    Directory of Open Access Journals (Sweden)

    Hui-Lin Mao

    2017-11-01

    Full Text Available Objective: To study the regulating effect of Par-4 gene overexpression on the nephroblastoma sensitivity to cisplatin. Methods: Nephroblastoma SK-NEP-1 cells were cultured and divided into four groups, control group were treated with RMPI-1640 without serum or drugs, cisplatin group were treated with serum-free RMPI-1640 containing 5 μg/mL cisplatin, Par-4 group were transfected by Par-4 overexpression plasmids with serum-free RMPI-1640, and cisplatin + Par-4 group were transfected by Par-4 overexpression plasmid with serum-free RMPI-1640 containing 5 μg/mL cisplatin. The cell proliferation activity as well the expression of apoptosis genes, migration genes and invasion genes was measured. Results: 8 h, 16 h and 24 h after different conditions of treatment, the cell proliferation activity of cisplatin group, Par-4 group and cisplatin + Par-4 group were significantly lower than that of control group, and the cell proliferation activity of cisplatin + Par-4 group was significantly lower than that of cisplatin group and Par-4 group; 24 h after different conditions of treatment, Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin group, Par-4 group and cisplatin + Par-4 group were greatly higher than those in control group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly lower than those in control group; Bim, PDCD4, WT1, RGS4, Axin, KAI1, E-cadherin, PPARγ and PTEN mRNA expression in cisplatin + Par-4 group were greatly higher than those in cisplatin group and Par-4 group whereas GDNF, GFRα1, TUBB3, NME1 and FGF1 mRNA expression were greatly significantly lower than those in cisplatin group and Par-4 group. Conclusion: Par-4 gene overexpression can increase the nephroblastoma sensitivity to cisplatin, reduce cell proliferation activity, promote apoptosis and inhibit cell migration and invasion.

  5. Planar Cell Polarity Breaks the Symmetry of PAR Protein Distribution prior to Mitosis in Drosophila Sensory Organ Precursor Cells.

    Science.gov (United States)

    Besson, Charlotte; Bernard, Fred; Corson, Francis; Rouault, Hervé; Reynaud, Elodie; Keder, Alyona; Mazouni, Khalil; Schweisguth, François

    2015-04-20

    During development, cell-fate diversity can result from the unequal segregation of fate determinants at mitosis. Polarization of the mother cell is essential for asymmetric cell division (ACD). It often involves the formation of a cortical domain containing the PAR complex proteins Par3, Par6, and atypical protein kinase C (aPKC). In the fly notum, sensory organ precursor cells (SOPs) divide asymmetrically within the plane of the epithelium and along the body axis to generate two distinct cells. Fate asymmetry depends on the asymmetric localization of the PAR complex. In the absence of planar cell polarity (PCP), SOPs divide with a random planar orientation but still asymmetrically, showing that PCP is dispensable for PAR asymmetry at mitosis. To study when and how the PAR complex localizes asymmetrically, we have used a quantitative imaging approach to measure the planar polarization of the proteins Bazooka (Baz, fly Par3), Par6, and aPKC in living pupae. By using imaging of functional GFP-tagged proteins with image processing and computational modeling, we find that Baz, Par6, and aPKC become planar polarized prior to mitosis in a manner independent of the AuroraA kinase and that PCP is required for the planar polarization of Baz, Par6, and aPKC during interphase. This indicates that a "mitosis rescue" mechanism establishes asymmetry at mitosis in PCP mutants. This study therefore identifies PCP as the initial symmetry-breaking signal for the planar polarization of PAR proteins in asymmetrically dividing SOPs. Copyright © 2015 Elsevier Ltd. All rights reserved.

  6. écrivain-e. Par-delà le genre – par-delà le corps ?

    Directory of Open Access Journals (Sweden)

    Cécile Chamayou-Kuhn

    2009-12-01

    Full Text Available Cet article propose d’étudier la relation qu’entretiennent, d’une part, le langage et le corps et, d’autre part, la parole et l’identité sexuelle dans Die Kränkung d’Evelyn Schlag et Der Tod und das Mädchen : III (Rosamunde ; V (Die Wand d’Elfriede Jelinek. Malgré les divergences de ton que présentent ces oeuvres, qui appartiennent à deux genres littéraires différents, il semble permis de centrer l’analyse sur une problématique commune : le personnage de « l’écrivain-e » parvient-il à saisir son propre corps ? Dans cette perspective, nous nous appuyons sur la critique formulée par Judith Butler à l’égard de la psychanalyse lacanienne, tout en considérant sa théorie sur la construction discursive du corps. Trois thématiques peuvent être développées : la dialectique de « l’in-visibilité » féminine, les processus de matérialisation du corps et la pratique subversive de la mascarade en tant qu’elle met en évidence certains mécanismes d’aliénation dans le cadre d’une genèse du corps et de l’écriture. Aussi peut-on affirmer que le drame du corps investi symboliquement sous-tend ces œuvres : l’écrivain-e tente de s’extraire de l’ordre symbolique et de saper les fondements des catégories constitutives de l’identité que sont le désir, le sexe biologique (sex et l’identité sexuelle (gender. Si les processus d’écriture laissent envisager un dépassement de l’offense narcissique et de la maladie dans Die Kränkung, un tel dénouement paraît exclu dans l’univers jelinekien : ses « héroïnes », qui évoluent comme autant de fantômes du signifiant, entament une éternelle danse de mort.Untersucht wird im folgenden Artikel – anhand der Texte Die Kränkung von Evelyn Schlag und Der Tod und das Mädchen III (Rosamunde und V (Die Wand von Elfriede Jelinek – das Verhältnis von Sprache zum Körper sowie die Beziehung zwischen Sprechen und

  7. Parasitoses intestinais se associam a menores índices de peso e estatura em escolares de baixo estrato socioeconômico Parasitosis intestinales se asocian con menores índices de peso y estatura en niños de bajo nivel económico Intestinal parasitoses are associated with lower values of weight and height in school-aged children from low socioeconomic level

    Directory of Open Access Journals (Sweden)

    Humberto B. Araujo Filho

    2011-12-01

    Full Text Available OBJETIVO: Avaliar a prevalência de parasitoses intestinais, correlacionando-as com os fatores socioeconômicos e ambientais, peso, estatura e hemoglobina, em crianças de dois estratos socioeconômicos, no município de Osasco (SP. MÉTODOS: Estudo transversal, comparando 84 crianças de seis a dez anos, residentes em área sem saneamento básico e moradia precária, com 35 crianças de escola particular no mesmo município, que possuíam boas condições socioeconômicas e de moradia. Excluíram-se aquelas com diarreia há menos de 30 dias ou doença grave. Utilizou-se questionário padronizado para avaliar as condições socioambientais. A avaliação nutricional foi realizada mediante escores Z de peso para idade, estatura para idade e índice de massa corpórea. A determinação da hemoglobina em amostra de sangue capilar foi realizada pelo método Hemocue® e a pesquisa de parasitas intestinais, pelos métodos de Hoffman, Ritchie, Kinyoun e swab anal. RESULTADOS: Parasitose intestinal ocorreu em 60,7% das crianças da favela e em 5,9% das crianças da escola particular (pOBJETIVO: Evaluar la prevalencia de parasitosis intestinales correlacionándolas con los factores socioeconómicos y ambientales, peso, estatura y hemoglobina, en niños de dos niveles socioeconómicos en el municipio de Osasco, São Paulo (Brasil. MÉTODOS: Se realizó un estudio transversal, comparando 84 niños entre 6 y 10 años, residentes en área sin saneamiento ambiental y vivienda precaria, con 35 niños de escuela privada en el mismo municipio, que poseían buenas condiciones socioeconómicas y de vivienda. Se excluyeron aquellas con diarrea hace menos de 30 días o enfermedad grave. Se utilizó cuestionario estandarizado para evaluar las condiciones socioambientales. La evaluación nutricional fue realizada mediante escores Z de peso para la edad, estatura para la edad e índice de masa corporal. La determinación de la hemoglobina en muestra de sangre capilar

  8. Filtrage Lineaire par Morceaux Avec Petit Bruit d’Observation (Piecewise Linear Filtering with Small Observation Noise)

    Science.gov (United States)

    1990-11-19

    L’UNIXJERSITt DE PRO VENCE Sp~cialit6: MATHEMATIQUES APPLIQUPES pill Marie-Christine ROUBAUD Sujet de la fljese FILTRAGE LINEAIRE PAR MORCEAUX AVEC PETIT BRUIT...paa CENTRE ST-CHARLES pour obtenir le titre de DOCTEUR DE L’UNIVERSITE DE PRO VENCE MATHEMATIQUES APPLIQUEES par Marie-Christine ROUBAUD Sujet de la th

  9. Plasma levels of intact and cleaved urokinase plasminogen activator receptor (uPAR) in men with clinically localised prostate cancer

    DEFF Research Database (Denmark)

    Kristensen, Gitte; Berg, Kasper Drimer; Lippert, Solvej

    2017-01-01

    1 disease. Soluble uPAR forms were measured using three time-resolved fluorescence immunoassays. The prognostic value of the different uPAR forms together with clinicopathological parameters for N1 disease were analysed using logistic regression, receiver operating characteristic (ROC) regression...

  10. ‘Focus on the Learner’ in Teacher Education : PAR as a Strategy to Enable Student Voice in Schools

    NARCIS (Netherlands)

    Smit, B.H.J.; Admiraal, W.F.; Berry, A.K.

    2017-01-01

    The current presentation addresses characteristics of the TE program, PSTs learning outcomes, and enabling and constraining factors in the development and enactment of PAR. Research questions:What are the characteristics of a TE program aimed at preparing PSTs for conducting PAR with school

  11. Contamination des eaux souterraines par le lixiviat des décharges ...

    African Journals Online (AJOL)

    La percolation du lixiviat en provenance des dechets des decharges constitue une source de pollution des ressources en eau souterraine par infiltration, constituant ainsi une menace aussi importante que celle liee a l'accentuation du deficit hydrique. La decharge publique de Larache constitue un modele type de ...

  12. Funding Research Through the Online Partnership to Accelerate Research (OnPAR

    Directory of Open Access Journals (Sweden)

    Martin A. Dueñas, MPA

    2016-10-01

    Full Text Available OnPAR—the Online Partnership to Accelerate Research—seeks to provide a second opportunity for funding of high-quality, unfunded applications originally submitted to the National Institutes of Health and other national and international funding agencies. OnPAR will match applicable, unfunded applications with the research priorities of nongovernment organizations such as private biomedical foundations, pharmaceutical companies, venture capital funds, and other private funds. Funding organization members will review and make final funding decisions through a simple, 2-step process whereby applicants can submit public abstracts directly to OnPAR. If a member requests additional information, then, by invitation only, an applicant can submit their original unfunded application and their peer review summary statement. Advancing research discovery and drug development to improve clinical outcomes for patients afflicted with or at risk for disease is the primary goal of OnPAR. OnPAR invites the scientific community to fully participate in this new funding paradigm by submitting their National Institutes of Health public abstracts so that funding members can review and potentially support these high-quality, unfunded applications.

  13. Accroissement de l'autonomisation économique des femmes par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    Par ailleurs, on observe également des écarts importants au sein même de la population féminine : les femmes pauvres et sans formation occupent un emploi rémunéré dans une proportion moindre que les autres ... Six world-class research teams to investigate overcoming therapeutic resistance in high fatality cancers.

  14. Accroissement de l'autonomisation économique des femmes par l ...

    International Development Research Centre (IDRC) Digital Library (Canada)

    ... des sexes sur le marché du travail et d'offrir de meilleures possibilités économiques aux femmes. La direction du projet sera assurée par le Centro Interdisciplinario de Estudios sobre el Desarrollo, en Uruguay, en collaboration avec le Centro de Estudios Distributivos Laborales y Sociales de l'Universidad Nacional de La ...

  15. La fabrication de l'"Autre" par le pouvoir : Entretien avec Christine Delphy

    OpenAIRE

    Delphy, Christine; Bertaux, Daniel; Delcroix, Catherine; Pfefferkorn, Roland

    2011-01-01

    International audience; Il s'agit d'un entretien mené avec Christine Delphy sur le thème "précarités, racismes et résistances"Propos recueillis par Daniel Bertaux et Catherine Delcroix et Roland Pfefferkorn.

  16. Préparation des charbons actifs par voie chimique à l'acide ...

    African Journals Online (AJOL)

    Les matieres ligno-cellulosiques sont des precurseurs du charbon actif. Le present travail a eu pour but la preparation de charbons actifs a partir des coques de noix de coco par activation chimique a lfacide phosphorique. Pour optimiser le procede de la preparation, les effets des concentrations de lfacide phosphorique ...

  17. Elimination du cadmium de l'acide phosphorique par électrodialyse ...

    African Journals Online (AJOL)

    homme; elle est devenue un enjeu économique et politique majeur pour le développement durable des pays. L'acide phosphorique est classé en second lieu dans la production mondiale des acides après l'acide sulfurique. Il est fabriqué par ...

  18. Parásitos de animales silvestres en cautiverio en Lima, Perú

    Directory of Open Access Journals (Sweden)

    Lily Arrojo

    2013-06-01

    Full Text Available Los parásitos de los animales silvestres en cautiverio peruanos se registran aquí. La mayoría de las especies son nematodos. Dos especies son al patógeno de host: Prosthenorchois elegans y Strongyloides sp.

  19. Que sont devenues les plantes autrefois consommées par les divers ...

    African Journals Online (AJOL)

    Que sont devenues les plantes autrefois consommées par les divers groupes ethnoculturels du Togo? S Akpavi, AY Woegan, M Dourma, K Tozo, K Batawila, K Wala, KA Gbogbo, M Kanda, K Kossi-Titrikou, B de Foucault, I Butare, K Akpagana ...

  20. Représentations du lexique par les formateurs et les enseignants en ...

    African Journals Online (AJOL)

    Cependant, l'enquête par questionnaire a été retenue car elle est moins exigeante en terme de temps et de logistique. Dix écoles publiques et privées de Dar es salaam (Zanaki, Kisutu, Makongo,Kibasila, Azania, Academic International school, Aghakhan Secondary School, Loyola, Tusiime, Heritage Secondary school) ...

  1. Synthèse optimale de prise de terre par la structure du sol selon la ...

    African Journals Online (AJOL)

    Synthèse optimale de prise de terre par la structure du sol selon la méthode des elements finis. S Houndedako, C Martinez, K Bedja, JM Kauffmann. Abstract. No Abstract Available Journal des Sciences pour l\\'Ingenieur Vol 5 2005: 27-33. Full Text: EMAIL FULL TEXT EMAIL FULL TEXT · DOWNLOAD FULL TEXT ...

  2. Tuberculosis prevalence and risk factors for water buffalo in Pará, Brazil.

    Science.gov (United States)

    Barbosa, José D; da Silva, Jenevaldo B; Rangel, Charles P; da Fonseca, Adivaldo H; Silva, Natália S; Bomjardim, Henrique A; Freitas, Nayra F Q R

    2014-03-01

    The prevalence of and possible risk factors for tuberculosis were studied in water buffalo from Pará, Brazil. In this study, 3,917 pregnant and nonpregnant female Murrah and Mediterranean buffaloes were studied; 2,089 originated from Marajó Island, and 1,108 were from the mainland. The comparative cervical tuberculin test was used as a diagnostic test for tuberculosis in these animals. The prevalence of positive buffaloes was 3.5 % (100/2,809) on Marajó Island and 7.2 % (80/1,108) on the mainland. The municipalities with the highest tuberculosis prevalence rates in animals were Ipixuna do Pará (10.1 %), Marapanim (9.8 %), Chaves (9.4 %), Paragominas (8.6 %), and Cachoeira do Arari (6.7 %). The tuberculosis prevalence was not significantly different between the Murrah (4.3 %) and Mediterranean (4.8 %) breeds or between pregnant (5 %) and nonpregnant (4.3 %) buffaloes. Tuberculosis was detected in water buffaloes from Pará, Brazil; the mainland buffalo exhibited the highest tuberculosis prevalence. These results indicate that this disease is dangerous to public health and buffalo farming in Pará.

  3. SuPAR Predicts Cardiovascular Events and Mortality in Patients With Asymptomatic Aortic Stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W.; Bang, Casper N; Eugen-Olsen, Jesper

    2016-01-01

    valve events (AVEs), cardiovascular and all-cause mortality after adjusting for traditional cardiovascular risk factors, and allocation to treatment. Results The multivariate adjusted hazard ratio (HR) (95% confidence interval [CI]) per unit log2 ng/mL increase in suPAR was HR, 1.5; 95% CI, 1.2-1.9; P...

  4. Dual Role of Host Par2 in a Murine Model of Spontaneous Metastatic B16 Melanoma

    Czech Academy of Sciences Publication Activity Database

    Olejár, Tomáš; Větvička, D.; Zadinová, M.; Poučková, P.; Kukal, J.; Ježek, Petr; Matěj, R.

    2014-01-01

    Roč. 34, č. 7 (2014), s. 3511-3515 ISSN 0250-7005 R&D Projects: GA ČR(CZ) GAP302/10/0346 Institutional support: RVO:67985823 Keywords : PAR2 * melanoma * metastasis * murine model Subject RIV: EA - Cell Biology Impact factor: 1.826, year: 2014

  5. Ambroise Paré (1510-1590)--Traek af kirurgfagets historie og dets medi- kamentelle aspekter

    DEFF Research Database (Denmark)

    Norn, Svend; Permin, Henrik; Kruse, Poul R

    2010-01-01

    the painful practise of cautery to stop bleeding and used ligatures and dressings instead. A multitude of subjects were included in his writings such as military surgery, aneurysm, hernia, obstetrics and plague, and through his techniques he guided the development of the gentle art of surgery. Paré became...

  6. ACUTE INTRAOPERATIVE SUPRACHOROIDAL HEMORRHAGE DURING SMALL-GAUGE PARS PLANA VITRECTOMY.

    Science.gov (United States)

    Sukpen, Intira; Stewart, Jay M

    2017-11-16

    To report the intraoperative occurrence of acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy. A review of a surgical patient who developed acute intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia. A 32-year-old obese woman with proliferative diabetic retinopathy and traction retinal detachment in the left eye who developed intraoperative suprachoroidal hemorrhage during small-gauge pars plana vitrectomy because of bucking under general anesthesia while doing endolaser under air infusion. The pressure was immediately elevated to stabilize the hemorrhage without sclerotomy creation, and then gas (14% C3F8) was injected, with subsequent face-down positioning. The patient subsequently developed proliferative vitreoretinopathy, requiring additional surgery. The final visual acuity at 14-month follow-up was hand motions with a reattached retina in the left eye. Valsalva-induced suprachoroidal hemorrhage during pars plana vitrectomy under general anesthesia may result in sight-threatening visual consequences. Current small-gauge vitrectomy techniques using valved cannulas may allow for better intraoperative management of this complication through control of the intraocular pressure in a closed system.

  7. Jesus en geweld: Markus 12:1-12 (en par) en Thomas 65 | van Eck ...

    African Journals Online (AJOL)

    Jesus and violence: Mark 12:1-12 (and par) and. Thomas 65. As an advanced agrarian (aristocratic) society, first-century Palestine's social fabric was built on systemic tensions and conflicts between the elite (rulers) and the peasantry (the ruled). At the root of these conflicts were incompatible values (ideologies) and

  8. Structure and ligand interactions of the urokinase receptor (uPAR)

    DEFF Research Database (Denmark)

    Kjaergaard, Magnus; Hansen, Line V.; Jacobsen, Benedikte

    2008-01-01

    The urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycolipid-anchored membrane glycoprotein, which is responsible for focalizing plasminogen activation to the cell surface through its high-affinity binding to the serine protease uPA. This tight interaction (KD less than 1 nM) ...

  9. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration.

    Science.gov (United States)

    Pichaud, Franck

    2018-01-01

    The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb) are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM) and zonula adherens (ZA) , thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1) gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  10. PAR-Complex and Crumbs Function During Photoreceptor Morphogenesis and Retinal Degeneration

    Directory of Open Access Journals (Sweden)

    Franck Pichaud

    2018-03-01

    Full Text Available The fly photoreceptor has long been used as a model to study sensory neuron morphogenesis and retinal degeneration. In particular, elucidating how these cells are built continues to help further our understanding of the mechanisms of polarized cell morphogenesis, intracellular trafficking and the causes of human retinal pathologies. The conserved PAR complex, which in flies consists of Cdc42-PAR6-aPKC-Bazooka, and the transmembrane protein Crumbs (Crb are key players during photoreceptor morphogenesis. While the PAR complex regulates polarity in many cell types, Crb function in polarity is relatively specific to epithelial cells. Together Cdc42-PAR6-aPKC-Bazooka and Crb orchestrate the differentiation of the photoreceptor apical membrane (AM and zonula adherens (ZA, thus allowing these cells to assemble into a neuro-epithelial lattice. In addition to its function in epithelial polarity, Crb has also been shown to protect fly photoreceptors from light-induced degeneration, a process linked to Rhodopsin expression and trafficking. Remarkably, mutations in the human Crumbs1 (CRB1 gene lead to retinal degeneration, making the fly photoreceptor a powerful disease model system.

  11. SuPAR predicts postoperative complications and mortality in patients with asymptomatic aortic stenosis

    DEFF Research Database (Denmark)

    Hodges, Gethin W; Bang, Casper N; Eugen-Olsen, Jesper

    2018-01-01

    . Methods: Baseline plasma suPAR levels were available in 411 patients who underwent AVR surgery during follow-up in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study. Cox analyses were used to evaluate suPAR in relation to all-cause mortality and the composite endpoint of postoperative...... complications (all-cause mortality, congestive heart failure, stroke and renal impairment) occurring in the 30-day postoperative period. Results: Patients with initially higher levels of suPAR were at increased risk of postoperative mortality with a HR of 3.5 (95% CI 1.4 to 9.0, P=0.008) and postoperative.......7 (95% CI 1.0 to 7.8, P=0.061); and postoperative complications with a HR of 2.5 (95% CI 1.3 to 5.0, P=0.007) and 2.4 (95% CI 1.2 to 4.8, P=0.011), respectively. Conclusion: Higher baseline suPAR levels are associated with an increased risk for postoperative complications and mortality in patients...

  12. Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination

    DEFF Research Database (Denmark)

    Juncker-Jensen, Anna; Deryugina, Elena I; Rimann, Ivo

    2013-01-01

    non-tumor-cell/non-matrix target, activation of which by carcinoma-produced MMP-1 regulates endothelial permeability and transendothelial migration. The inhibitory effects of specific PAR1 antagonists in live animals have also indicated that the mechanisms of MMP-1-dependent vascular permeability...

  13. CALiPER Report 20.3: Robustness of LED PAR38 Lamps

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2014-12-30

    A small sample of each of the CALiPER Application Summary Report 20 PAR38 lamp types underwent stress testing that included substantial temperature and humidity changes, electrical variation, and vibration. The results do not directly address expected lifetime, but can be compared with one another, as well as with benchmark conventional products, to assess the relative robustness of the product designs.

  14. La bio-indication de la pollution aquatique par les microalgues (Cas ...

    African Journals Online (AJOL)

    des Cyanophyceae au niveau de l'Oued. Bounamoussa. D'apres Collectif [13], la presence de Cyanophyceae perturbe la croissance des autres groupes d'algues, principalement les. Chlorophyceae, par competition vis-a-vis de deux elements vitaux, la lumiere et les sels mineraux, principalement le phosphore et l'azote.

  15. CRP and suPAR are differently related to anthropometry and subclinical organ damage

    DEFF Research Database (Denmark)

    Lyngbæk, Stig; Sehestedt, Thomas; Marott, Jacob L

    2013-01-01

    of the inflammation associated with CVD. METHODS: We studied 2273 subjects without CVD. Log-transformed CRP and suPAR were included in general linear and logistic regression models to compare associations with measures of anthropometry and subclinical organ damage (SOD). Owing to interactions on body mass index (BMI...

  16. PAR as a way of organising a social workers labour union in Greenland

    DEFF Research Database (Denmark)

    Andersen, John; Arnfjord, Steven

    Abstract, ALARA2015012:PAR as a way of organising a social workers labour union in Greenland for consideration and inclusion in the programme for the ALARA 9th Action Learning Action Research and 13th Participatory Action Research World Congress to be held at St. George Hotel and Conference Centre...

  17. Par@Graph - a parallel toolbox for the construction and analysis of large complex climate networks

    NARCIS (Netherlands)

    Tantet, A.J.J.

    2015-01-01

    In this paper, we present Par@Graph, a software toolbox to reconstruct and analyze complex climate networks having a large number of nodes (up to at least 106) and edges (up to at least 1012). The key innovation is an efficient set of parallel software tools designed to leverage the inherited hybrid

  18. Determining fPAR and leaf area index of several land cover classes ...

    African Journals Online (AJOL)

    ... fraction of photosynthetically active radiation (fPAR), are three fundamental biophysical characteristics of the plant canopy that should parameterise ecophysiological models of water use (evapotranspiration) and carbon sequestration. Although Earth observation provides values and time series for both these parameters, ...

  19. Élaboration de films minces de tellurure de bismuth par voie chimique

    Science.gov (United States)

    Scidone, L.; Boulanger, C.; Lecuire, J. M.; Diliberto, S.

    2004-12-01

    La miniaturisation de modules Peltier passe par la recherche de techniques de synthèse appropriées pour l’élaboration de film minces d’alliages de matériaux thermoélectriques. Les procédés de synthèse couramment rencontrés sont basés sur différents principes présentant de nombreux inconvénients techniques. Une technique plus simple d’élaboration par déposition chimique de ces matériaux de type Bi2Te3 sous forme de films minces a été étudiée. Les dépôts ont été effectués à partir de solutions de TeIV et BiIII dissous en milieu nitrique à température ambiante. La réduction de ces cations a été envisagée selon deux voies. D’une part par l’utilisation de différents réducteurs solubles et d’autre part par action de métaux purs. L’influence de la concentration en cations métalliques et le rapport BiIII/TeIV des solutions ont été étudiés. Les produits de synthèse ont été identifiés par diffraction des rayons X, l’aspect des films a été observé par microscopie électronique à balayage. Enfin, la cinétique de croissance d’un film thermoélectrique a été étudiée par suivi gravimétrique pour des temps de déposition assez longs (>30 min) et sur microbalance à quartz pour des temps de déposition courts (< 30 min).

  20. Radiological findings and healing patterns of incomplete stress fractures of the pars interarticularis

    International Nuclear Information System (INIS)

    Dunn, Andrew J.; Campbell, Robert S.D.; Mayor, Peter E.; Rees, Dai

    2008-01-01

    The objective was to retrospectively record the CT and MRI features and healing patterns of acute, incomplete stress fractures of the pars interarticularis. The CT scans of 156 adolescents referred with suspected pars interarticularis stress fractures were reviewed. Patients with incomplete (grade 2) pars fractures were included in the study. Fractures were assessed on CT according to vertebral level, location of cortical involvement and direction of fracture propagation. MRI was also performed in 72 of the 156 cases. MRI images of incomplete fractures were assessed for the presence of marrow oedema and cortical integrity. Fracture healing patterns were characterised on follow-up CT imaging. Twenty-five incomplete fractures were identified in 23 patients on CT. All fractures involved the inferior or infero-medial cortex of the pars and propagated superiorly or superolaterally. Ninety-two percent of incomplete fractures demonstrated either complete or partial healing on follow-up imaging. Two (8%) cases progressed to complete fractures. Thirteen incomplete fractures in 11 patients confirmed on CT also had MRI, and 92% demonstrated oedema in the pars. Ten out of thirteen fractures (77%) showed a break in the infero-medial cortex with intact supero-lateral cortex, which correlated with the CT findings. MRI incorrectly graded one case as a complete (grade 3) fracture, and 2 cases as (grade 1) stress reaction. Six fractures had follow-up MRI, 67% showed partial or complete cortical healing, and the same number showed persistent marrow oedema. Incomplete fracture of the pars interarticularis represents a stage of the evolution of a complete stress fracture. The direction of fracture propagation is consistent, and complete healing can be achieved in most cases with appropriate clinical management. CT best demonstrates fracture size and extent, and is the most appropriate modality for follow-up. MRI is limited in its ability to fully depict the cortical integrity of