Seeking excellence: An evaluation of 235 international laboratories conducting water isotope analyses by isotope-ratio and laser-absorption spectrometry.

Science.gov (United States)

Wassenaar, L I; Terzer-Wassmuth, S; Douence, C; Araguas-Araguas, L; Aggarwal, P K; Coplen, T B

2018-03-15

Water stable isotope ratios (δ 2 H and δ 18 O values) are widely used tracers in environmental studies; hence, accurate and precise assays are required for providing sound scientific information. We tested the analytical performance of 235 international laboratories conducting water isotope analyses using dual-inlet and continuous-flow isotope ratio mass spectrometers and laser spectrometers through a water isotope inter-comparison test. Eight test water samples were distributed by the IAEA to international stable isotope laboratories. These consisted of a core set of five samples spanning the common δ-range of natural waters, and three optional samples (highly depleted, enriched, and saline). The fifth core sample contained unrevealed trace methanol to assess analyst vigilance to the impact of organic contamination on water isotopic measurements made by all instrument technologies. For the core and optional samples ~73 % of laboratories gave acceptable results within 0.2 ‰ and 1.5 ‰ of the reference values for δ 18 O and δ 2 H, respectively; ~27 % produced unacceptable results. Top performance for δ 18 O values was dominated by dual-inlet IRMS laboratories; top performance for δ 2 H values was led by laser spectrometer laboratories. Continuous-flow instruments yielded comparatively intermediate results. Trace methanol contamination of water resulted in extreme outlier δ-values for laser instruments, but also affected reactor-based continuous-flow IRMS systems; however, dual-inlet IRMS δ-values were unaffected. Analysis of the laboratory results and their metadata suggested inaccurate or imprecise performance stemmed mainly from skill- and knowledge-based errors including: calculation mistakes, inappropriate or compromised laboratory calibration standards, poorly performing instrumentation, lack of vigilance to contamination, or inattention to unreasonable isotopic outcomes. To counteract common errors, we recommend that laboratories include 1-2 'known

Seeking excellence: An evaluation of 235 international laboratories conducting water isotope analyses by isotope-ratio and laser-absorption spectrometry

Science.gov (United States)

Wassenaar, L. I.; Terzer-Wassmuth, S.; Douence, C.; Araguas-Araguas, L.; Aggarwal, P. K.; Coplen, Tyler B.

2018-01-01

RationaleWater stable isotope ratios (δ2H and δ18O values) are widely used tracers in environmental studies; hence, accurate and precise assays are required for providing sound scientific information. We tested the analytical performance of 235 international laboratories conducting water isotope analyses using dual-inlet and continuous-flow isotope ratio mass spectrometers and laser spectrometers through a water isotope inter-comparison test.MethodsEight test water samples were distributed by the IAEA to international stable isotope laboratories. These consisted of a core set of five samples spanning the common δ-range of natural waters, and three optional samples (highly depleted, enriched, and saline). The fifth core sample contained unrevealed trace methanol to assess analyst vigilance to the impact of organic contamination on water isotopic measurements made by all instrument technologies.ResultsFor the core and optional samples ~73 % of laboratories gave acceptable results within 0.2 ‰ and 1.5 ‰ of the reference values for δ18O and δ2H, respectively; ~27 % produced unacceptable results. Top performance for δ18O values was dominated by dual-inlet IRMS laboratories; top performance for δ2H values was led by laser spectrometer laboratories. Continuous-flow instruments yielded comparatively intermediate results. Trace methanol contamination of water resulted in extreme outlier δ-values for laser instruments, but also affected reactor-based continuous-flow IRMS systems; however, dual-inlet IRMS δ-values were unaffected.ConclusionsAnalysis of the laboratory results and their metadata suggested inaccurate or imprecise performance stemmed mainly from skill- and knowledge-based errors including: calculation mistakes, inappropriate or compromised laboratory calibration standards, poorly performing instrumentation, lack of vigilance to contamination, or inattention to unreasonable isotopic outcomes. To counteract common errors, we recommend that

Characterization of uranium isotopic abundances in depleted uranium metal assay standard 115

International Nuclear Information System (INIS)

Mathew, K.J.; Singleton, G.L.; Essex, R.M.; Hasozbek, A.; Orlowicz, G.; Soriano, M.

2013-01-01

Certified reference material (CRM) 115, Uranium (Depleted) Metal (Uranium Assay Standard), was analyzed using a TRITON Thermal Ionization Mass Spectrometer to characterize the uranium isotope-amount ratios. The certified 235 U/ 238 U 'major' isotope-amount ratio of 0.0020337 (12) in CRM 115 was determined using the total evaporation (TE) and the modified total evaporation (MTE) analytical techniques. In the MTE method, the total evaporation process is interrupted on a regular basis to allow correction of background from peak tailing, internal calibration of the secondary electron multiplier detector versus the Faraday cups, peak-centering, and ion source re-focusing. For the 'minor' 234 U/ 238 U and 236 U/ 238 U isotope-amount ratio measurements using MTE, precision and accuracy comparable to conventional analyses are achieved, without compromising the quality of the 235 U/ 238 U isotope-amount ratios. Characterized values of the 234 U/ 238 U and 236 U/ 238 U isotope-amount ratios in CRM 115 are 0.000007545 (10) and 0.000032213 (84), respectively. The 233 U/ 238 U isotope-amount ratio in CRM 115 is estimated to be -9 . The homogeneity of the CRM 115 materials is established through the absence of any statistically significant unit-to-unit variation in the uranium isotope-amount ratios. The measurements leading to the certification of uranium isotope-amount ratios are discussed. (author)

Uncertainty evaluation in normalization of isotope delta measurement results against international reference materials.

Science.gov (United States)

Meija, Juris; Chartrand, Michelle M G

2018-01-01

Isotope delta measurements are normalized against international reference standards. Although multi-point normalization is becoming a standard practice, the existing uncertainty evaluation practices are either undocumented or are incomplete. For multi-point normalization, we present errors-in-variables regression models for explicit accounting of the measurement uncertainty of the international standards along with the uncertainty that is attributed to their assigned values. This manuscript presents framework to account for the uncertainty that arises due to a small number of replicate measurements and discusses multi-laboratory data reduction while accounting for inevitable correlations between the laboratories due to the use of identical reference materials for calibration. Both frequentist and Bayesian methods of uncertainty analysis are discussed.

A proposed standard on medical isotope production in fission reactors

International Nuclear Information System (INIS)

Schenter, R. E.; Brown, G. J.; Holden, C. S.

2006-01-01

Authors Robert E. Sehenter, Garry Brown and Charles S. Holden argue that a Standard for 'Medical Isotope Production' is needed. Medical isotopes are becoming major components of application for the diagnosis and treatment of all the major diseases including all forms of cancer, heart disease, arthritis, Alzheimer's, among others. Current nuclear data to perform calculations is incomplete, dated or imprecise or otherwise flawed for many isotopes that could have significant applications in medicine. Improved data files will assist computational analyses to design means and methods for improved isotope production techniques in the fission reactor systems. Initial focus of the Standard is expected to be on neutron cross section and branching data for both fast and thermal reactor systems. Evaluated and reviewed tables giving thermal capture cross sections and resonance integrals for the major target and product medical isotopes would be the expected 'first start' for the 'Standard Working Group'. (authors)

Results of the international Pu-2000 exercise for plutonium isotopic composition measurements

International Nuclear Information System (INIS)

Morel, J.; Bickel, M.; Hill, C.; Verbruggen, A.

2004-01-01

An international comparison for plutonium isotopic composition measurement, known as the Pu-2000 exercise, was organized by the ESARDA NDA-WG (European Safeguards Research and Development Association, Working Group on Techniques and Standards for Non-Destructive Assay). The aim of this comparison was to test X- and γ-ray spectrometry methods over a large range of isotopic ratios. These methods are based on the complex analysis of several X- and γ-rays in the KX region of the plutonium spectrum and also in the 120-700 keV energy range. The results obtained by the participants with their corresponding uncertainties are presented in this document and compared to the declared values. The main conclusions of the work are also given. No important bias due to an inadequate knowledge of the nuclear data for plutonium isotopes was observed

Development of the NBS beryllium isotopic standard reference material

International Nuclear Information System (INIS)

Inn, K.G.W; Fassett, J.D.; Coursey, B.M.; Walker, R.L.; Raman, S.

1987-01-01

The National Bureau of Standards, in conjunction with the Oak Ridge National Laboratory and the Accelerator Mass Spectrometry community, is in the process of developing a beryllium isotopic solution Standard Reference Material. The master 10 Be/ 9 Be solution was characterized isotopically by resonance-ionization and secondary-ion mass-spectrometric-based techniques, and radioactivity measurements were by liquid scintillation counting. The master solution was gravimetrically diluted with 9 Be to a final 10 Be/ 9 Be atomic ratio of 3 x 10 -11 . The preliminary data indicate a half life for 10 Be of 1.3 million years, and AMS measurements are within 10% of the known beryllium isotopic ratio

Mass fragmentographic analysis of total cholesterol in serum using a heptadeuterated internal standard

International Nuclear Information System (INIS)

Wolthers, B.G.; Hindriks, F.R.; Muskiet, F.A.J.; Groen, A.

1980-01-01

A mass fragmentographic method for the determination of total cholesterol in serum using heptadeuterated [25,26,26,26,27,27,27- 2 H] cholesterol as internal standard is presented. The results obtained are compared with a colorimetric and gas chromatographic method which were previously proposed as reference methods. Criteria for the development of absolute measurement by means of mass fragmentography and stable isotopically labelled internal standards are given. The conclusion is drawn that, at present, mass fragmentographic methods for the determination of total cholesterol in serum do not fulfil the criteria required for absolute methods. (Auth.)

Development of isotope dilution-liquid chromatography/mass spectrometry combined with standard addition techniques for the accurate determination of tocopherols in infant formula

Energy Technology Data Exchange (ETDEWEB)

Lee, Joonhee; Jang, Eun-Sil; Kim, Byungjoo, E-mail: byungjoo@kriss.re.kr

2013-07-17

Graphical abstract: -- Highlights: •ID-LC/MS method showed biased results for tocopherols analysis in infant formula. •H/D exchange of deuterated tocopherols in sample preparation was the source of bias. •Standard addition (SA)-ID-LC/MS was developed as an alternative to ID-LC/MS. •Details of calculation and uncertainty evaluation of the SA-IDMS were described. •SA-ID-LC/MS showed a higher-order metrological quality as a reference method. -- Abstract: During the development of isotope dilution-liquid chromatography/mass spectrometry (ID-LC/MS) for tocopherol analysis in infant formula, biased measurement results were observed when deuterium-labeled tocopherols were used as internal standards. It turned out that the biases came from intermolecular H/D exchange and intramolecular H/D scrambling of internal standards in sample preparation processes. Degrees of H/D exchange and scrambling showed considerable dependence on sample matrix. Standard addition-isotope dilution mass spectrometry (SA-IDMS) based on LC/MS was developed in this study to overcome the shortcomings of using deuterium-labeled internal standards while the inherent advantage of isotope dilution techniques is utilized for the accurate recovery correction in sample preparation processes. Details of experimental scheme, calculation equation, and uncertainty evaluation scheme are described in this article. The proposed SA-IDMS method was applied to several infant formula samples to test its validity. The method was proven to have a higher-order metrological quality with providing very accurate and precise measurement results.

Preparation and certification of solutions of perdeuterated polycyclic aromatic compounds intended for use as surrogate internal standards

International Nuclear Information System (INIS)

Quilliam, M.A.; Hardstaff, W.R.; Anacleto, J.F.; LeBlanc, M.D.; Stergiopoulos, V.; Dick, K.L.; Bowser, M.T.; Curtis, J.M.; Embree, D.J.; Sim, P.G.; Boyd, R.K.

1994-01-01

Two standard solutions of deuterated polycyclic aromatic compounds (PACs) have been prepared for use as surrogate internal standards. Solution DPAC-1 contains 21 deuterated PACs, and is intended for use with mass spectrometric (MS) detection. Most of the difficulties in certifying concentrations in DPAC-1 arose from the fact that none of the individual compounds was 100% deuterated, so that effects of mass spectrometric fragmentation are convoluted with those of isotopic distributions. The best methods are discussed for using such internal standards so as to minimize these problems, together with those arising from kinetic isotope effects. Solution DPAC-2 contains 6 deuterated PACs, and is primarily intended for use with reversed-phase high-performance liquid chromatography (HPLC) with fluorescence detection (FLD, dural programmed wavelength mode), in which the signals for analyte and internal standard are separated chromatographically rather than via the detector. Full details of the preparation of these solutions are described. In addition, examples of their use in the analysis of a certified coal-tar extract (NIST SRM 1597) are described briefly. In one example a novel HPLC-MS technique was employed, and in the other the HPLC-FLD technique was used. (orig.)

Innovative method for carbon dioxide determination in human postmortem cardiac gas samples using headspace-gas chromatography–mass spectrometry and stable labeled isotope as internal standard

International Nuclear Information System (INIS)

Varlet, V.; Smith, F.; Froidmont, S. de; Dominguez, A.; Rinaldi, A.; Augsburger, M.; Mangin, P.; Grabherr, S.

2013-01-01

Graphical abstract: -- Highlights: •We developed a method for CO 2 analysis in cardiac samples and quantification by 13 CO 2 . •This method was fully validated by accuracy profile. •We have applied this method to perform CO 2 precise quantification for forensic applications. •Context of the death could be documented following CO 2 concentrations. -- Abstract: A novel approach to measure carbon dioxide (CO 2 ) in gaseous samples, based on a precise and accurate quantification by 13 CO 2 internal standard generated in situ is presented. The main goal of this study was to provide an innovative headspace-gas chromatography–mass spectrometry (HS-GC–MS) method applicable in the routine determination of CO 2 . The main drawback of the GC methods discussed in the literature for CO 2 measurement is the lack of a specific internal standard necessary to perform quantification. CO 2 measurement is still quantified by external calibration without taking into account analytical problems which can often occur considering gaseous samples. To avoid the manipulation of a stable isotope-labeled gas, we have chosen to generate in situ an internal labeled standard gas ( 13 CO 2 ) on the basis of the stoichiometric formation of CO 2 by the reaction of hydrochloric acid (HCl) with sodium hydrogen carbonate (NaH 13 CO 3 ). This method allows a precise measurement of CO 2 concentration and was validated on various human postmortem gas samples in order to study its efficiency

Standard test method for isotopic analysis of uranium hexafluoride by double standard single-collector gas mass spectrometer method

CERN Document Server

American Society for Testing and Materials. Philadelphia

2010-01-01

1.1 This is a quantitative test method applicable to determining the mass percent of uranium isotopes in uranium hexafluoride (UF6) samples with 235U concentrations between 0.1 and 5.0 mass %. 1.2 This test method may be applicable for the entire range of 235U concentrations for which adequate standards are available. 1.3 This test method is for analysis by a gas magnetic sector mass spectrometer with a single collector using interpolation to determine the isotopic concentration of an unknown sample between two characterized UF6 standards. 1.4 This test method is to replace the existing test method currently published in Test Methods C761 and is used in the nuclear fuel cycle for UF6 isotopic analyses. 1.5 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.6 This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appro...

International Construction Measurement Standard

OpenAIRE

Mitchell, Charles

2016-01-01

The International Construction Measurement Standard Coalition (the Coalition) was formed on 17 June 2015 after meeting at the International Monetary Fund in Washington DC, USA. The Coalition, comprising the organisations listed below at the date of publication, aims to bring about consistency in construction cost reporting standards internationally. This is achieved by the creation and adoption of this ICMS, an agreed international standard for the structuring and presentation of cost reports...

Isotopic Abundance and Chemical Purity Analysis of Stable Isotope Deuterium Labeled Sudan I

Directory of Open Access Journals (Sweden)

CAI Yin-ping;LEI Wen;ZHENG Bo;DU Xiao-ning

2014-02-01

Full Text Available It is important that to analysis of the isotopic abundance and chemical purity of Sudan I-D5, which is the internal standard of isotope dilution mass spectrometry. The isotopic abundance of Sudan I-D5 is detected by “mass cluster” classification method and LC-MS. The repeatability and reproducibility experiments were carried out by using different mass spectrometers and different operators. The RSD was less than 0.1%, so the repeatability and reproducibility were satisfactory. The accuracy and precision of the isotopic abundance analysis method was good with the results of F test and t test. The high performance liquid chromatography (HPLC had been used for detecting the chemical purity of Sudan I-D5 as external standard method.

A quality control of proteomic experiments based on multiple isotopologous internal standards

Directory of Open Access Journals (Sweden)

Adele Bourmaud

2015-09-01

Full Text Available The harmonization of proteomics experiments facilitates the exchange and comparison of results. The definition of standards and metrics ensures reliable and consistent data quality. An internal quality control procedure was developed to assess the different steps of a proteomic analysis workflow and perform a system suitability test. The method relies on a straightforward protocol using a simple mixture of exogenous proteins, and the sequential addition of two sets of isotopically labeled peptides added to reference samples. This internal quality control procedure was applied to plasma samples to demonstrate its easy implementation, which makes it generic for most proteomics applications.

Innovative method for carbon dioxide determination in human postmortem cardiac gas samples using headspace-gas chromatography–mass spectrometry and stable labeled isotope as internal standard

Energy Technology Data Exchange (ETDEWEB)

Varlet, V., E-mail: vincent.varlet@chuv.ch [Toxicology and Forensic Chemistry Unit, University Center of Legal Medicine Lausanne – Geneva, CH-1011 Lausanne (Switzerland); Smith, F. [Toxicology and Forensic Chemistry Unit, University Center of Legal Medicine Lausanne – Geneva, CH-1011 Lausanne (Switzerland); Froidmont, S. de; Dominguez, A.; Rinaldi, A. [Forensic Medicine Unit, University Center of Legal Medicine Lausanne – Geneva, CH-1011 Lausanne (Switzerland); Augsburger, M. [Toxicology and Forensic Chemistry Unit, University Center of Legal Medicine Lausanne – Geneva, CH-1011 Lausanne (Switzerland); Mangin, P.; Grabherr, S. [Forensic Medicine Unit, University Center of Legal Medicine Lausanne – Geneva, CH-1011 Lausanne (Switzerland)

2013-06-19

Graphical abstract: -- Highlights: •We developed a method for CO{sub 2} analysis in cardiac samples and quantification by {sup 13}CO{sub 2}. •This method was fully validated by accuracy profile. •We have applied this method to perform CO{sub 2} precise quantification for forensic applications. •Context of the death could be documented following CO{sub 2} concentrations. -- Abstract: A novel approach to measure carbon dioxide (CO{sub 2}) in gaseous samples, based on a precise and accurate quantification by {sup 13}CO{sub 2} internal standard generated in situ is presented. The main goal of this study was to provide an innovative headspace-gas chromatography–mass spectrometry (HS-GC–MS) method applicable in the routine determination of CO{sub 2}. The main drawback of the GC methods discussed in the literature for CO{sub 2} measurement is the lack of a specific internal standard necessary to perform quantification. CO{sub 2} measurement is still quantified by external calibration without taking into account analytical problems which can often occur considering gaseous samples. To avoid the manipulation of a stable isotope-labeled gas, we have chosen to generate in situ an internal labeled standard gas ({sup 13}CO{sub 2}) on the basis of the stoichiometric formation of CO{sub 2} by the reaction of hydrochloric acid (HCl) with sodium hydrogen carbonate (NaH{sup 13}CO{sub 3}). This method allows a precise measurement of CO{sub 2} concentration and was validated on various human postmortem gas samples in order to study its efficiency.

International standards for radiation protection

International Nuclear Information System (INIS)

Ambrosi, P.

2011-01-01

International standards for radiation protection are issued by many bodies. These bodies differ to a large extent in their organisation, in the way the members are designated and in the way the international standards are authorised by the issuing body. Large differences also exist in the relevance of the international standards. One extreme is that the international standards are mandatory in the sense that no conflicting national standard may exist, the other extreme is that national and international standards conflict and there is no need to resolve that conflict. Between these extremes there are some standards or documents of relevance, which are not binding by any formal law or contract but are de facto binding due to the scientific reputation of the issuing body. This paper gives, for radiation protection, an overview of the main standards issuing bodies, the international standards or documents of relevance issued by them and the relevance of these documents. (authors)

Determination of bovine lactoferrin in dairy products by ultra-high performance liquid chromatography–tandem mass spectrometry based on tryptic signature peptides employing an isotope-labeled winged peptide as internal standard

Energy Technology Data Exchange (ETDEWEB)

Zhang, Jingshun [Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051 (China); Lai, Shiyun [Beingmate Research Institute, Beingmate Baby and Child Food Co., Ltd., Hangzhou 310007 (China); Cai, Zengxuan [Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051 (China); Chen, Qi [Beingmate Research Institute, Beingmate Baby and Child Food Co., Ltd., Hangzhou 310007 (China); Huang, Baifen [Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051 (China); Ren, Yiping, E-mail: renyiping@263.net [Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051 (China)

2014-06-01

Highlights: • A UHPLC–MS/MS method for quantification of bovine lactoferrin was developed. • Tryptic fragment LRPVAAEIYGTK was chosen as signature peptide of bovine lactoferrin. • A winged peptide containing isotopically-labeled signature peptide was designed as internal standard. • The method for determining lactoferrin does not discriminate between the different forms of lactoferrin. • Meet the growing demand to quantify bovine lactoferrin in different dairy products. Abstract: A new and sensitive determination method was developed for bovine lactoferrin in dairy products including infant formulas based on the signature peptide by ultra high-performance liquid chromatography and triple-quadrupole tandem mass spectrometry under the multiple reaction monitoring mode. The simple pretreatment procedures included the addition of a winged peptide containing the isotope-labeled signature peptide as internal standard, followed by an enzymatic digestion with trypsin. The signature peptide was chosen and identified from the tryptic hydrolyzates of bovine lactoferrin by ultra high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry based on sequence database search. Analytes were separated on an ACQUITY UPLC BEH 300 C18 column and monitored by MS/MS in seven minutes. Quantitative result bias due to matrix effect and tryptic efficiency was corrected through the use of synthetic isotope-labeled standards. The limit of detection and limit of quantification were 0.3 mg/100 g and 1.0 mg/100 g, respectively. Bovine lactoferrin within the concentration range of 10–1000 nmol L⁻¹ showed a strong linear relationship with a linear correlation coefficient (r) of >0.998. The intra- and inter-day precision of the method were RSD < 6.5% and RSD < 7.1%, respectively. Excellent repeatability (RSD < 6.4%) substantially supported the application of this method for the determination of bovine lactoferrin in dairy samples. The present method

Determination of bovine lactoferrin in dairy products by ultra-high performance liquid chromatography–tandem mass spectrometry based on tryptic signature peptides employing an isotope-labeled winged peptide as internal standard

International Nuclear Information System (INIS)

Zhang, Jingshun; Lai, Shiyun; Cai, Zengxuan; Chen, Qi; Huang, Baifen; Ren, Yiping

2014-01-01

Highlights: • A UHPLC–MS/MS method for quantification of bovine lactoferrin was developed. • Tryptic fragment LRPVAAEIYGTK was chosen as signature peptide of bovine lactoferrin. • A winged peptide containing isotopically-labeled signature peptide was designed as internal standard. • The method for determining lactoferrin does not discriminate between the different forms of lactoferrin. • Meet the growing demand to quantify bovine lactoferrin in different dairy products. - Abstract: A new and sensitive determination method was developed for bovine lactoferrin in dairy products including infant formulas based on the signature peptide by ultra high-performance liquid chromatography and triple-quadrupole tandem mass spectrometry under the multiple reaction monitoring mode. The simple pretreatment procedures included the addition of a winged peptide containing the isotope-labeled signature peptide as internal standard, followed by an enzymatic digestion with trypsin. The signature peptide was chosen and identified from the tryptic hydrolyzates of bovine lactoferrin by ultra high-performance liquid chromatography and quadrupole-time-of-flight tandem mass spectrometry based on sequence database search. Analytes were separated on an ACQUITY UPLC BEH 300 C18 column and monitored by MS/MS in seven minutes. Quantitative result bias due to matrix effect and tryptic efficiency was corrected through the use of synthetic isotope-labeled standards. The limit of detection and limit of quantification were 0.3 mg/100 g and 1.0 mg/100 g, respectively. Bovine lactoferrin within the concentration range of 10–1000 nmol L −1 showed a strong linear relationship with a linear correlation coefficient (r) of >0.998. The intra- and inter-day precision of the method were RSD < 6.5% and RSD < 7.1%, respectively. Excellent repeatability (RSD < 6.4%) substantially supported the application of this method for the determination of bovine lactoferrin in dairy samples. The present

Recent development in isotope ratio mass spectrometry

International Nuclear Information System (INIS)

Platzner, I.

1992-01-01

Within the limited of this review the following topics will be briefly discussed: a) Accuracy, precision, internal relative standard deviation (RISD) and external relative standard deviation (RESD) of isotope ratio measurements. With advanced instrumentation and use of standard reference materials, high accuracy and RESD = 0.002% (or better) may be achieved; b) The advantages of modern automatic isotope ratio mass spectrometer are briefly described. Computer controlled operation and data acquisition, and multiple ion collection are the recent important improvement; c) The isotopic fractionation during the course of isotope ratio measurement is considered as a major source of errors in thermal ionization of metallic elements. The phenomenon in strontium, neodymium, uranium, lead and calcium and methods to correct the measured data are discussed; d) Applications of isotope ratio mass spectrometry in atomic weight determinations, the isotope dilution technique, isotope geology, and isotope effects in biological systems are described together with specific applications in various research and technology area. (author)

New Carbonate Standard Reference Materials for Boron Isotope Geochemistry

Science.gov (United States)

Stewart, J.; Christopher, S. J.; Day, R. D.

2015-12-01

The isotopic composition of boron (δ11B) in marine carbonates is well established as a proxy for past ocean pH. Yet, before palaeoceanographic interpretation can be made, rigorous assessment of analytical uncertainty of δ11B data is required; particularly in light of recent interlaboratory comparison studies that reported significant measurement disagreement between laboratories [1]. Well characterised boron standard reference materials (SRMs) in a carbonate matrix are needed to assess the accuracy and precision of carbonate δ11B measurements throughout the entire procedural chemistry; from sample cleaning, to ionic separation of boron from the carbonate matrix, and final δ11B measurement by multi-collector inductively coupled plasma mass spectrometry. To date only two carbonate reference materials exist that have been value-assigned by the boron isotope measurement community [2]; JCp-1 (porites coral) and JCt-1 (Giant Clam) [3]. The National Institute of Standards and Technology (NIST) will supplement these existing standards with new solution based inorganic carbonate boron SRMs that replicate typical foraminiferal and coral B/Ca ratios and δ11B values. These new SRMs will not only ensure quality control of full procedural chemistry between laboratories, but have the added benefits of being both in abundant supply and free from any restrictions associated with shipment of biogenic samples derived from protected species. Here we present in-house δ11B measurements of these new boron carbonate SRM solutions. These preliminary data will feed into an interlaboratory comparison study to establish certified values for these new NIST SRMs. 1. Foster, G.L., et al., Chemical Geology, 2013. 358(0): p. 1-14. 2. Gutjahr, M., et al., Boron Isotope Intercomparison Project (BIIP): Development of a new carbonate standard for stable isotopic analyses. Geophysical Research Abstracts, EGU General Assembly 2014, 2014. 16(EGU2014-5028-1). 3. Inoue, M., et al., Geostandards and

The new international standard ISO 14001: 2004 environmental management system

International Nuclear Information System (INIS)

Oheba, Jamal Basher

2006-01-01

ISO 14001 is one standard in the ISO 14000 series of standards developed by International Organization of Standardization (ISO). Since it was published in 19096, it has rapidly become the most important environmental standard in the world. ISO 14001 is an environmental management system (EMS) that can be classified into environmental technologies provides a systematic procedure to all kind of organizations to prevent pollutions, protect environment and to improve their overall environmental performance. This new standard ISO 14001 2004 was published on November 15, 2004. It cancels and replaced the old ISO 14001-1996. Because the important of the previous standard for our local industries, firms, ...etc, this paper presents ISO 14001 concepts, issues, benefits and focuses on the stages of implementation to achieve ISO 14001-2004 certification which includes general requirements environmental policy, planning (objectives, targets ..), implementation and operations, checking and management review ...etc and presents how to apply isotop time saver software to design records, and to save time to implement ISO 14001 2004 and finally a conclusion is provided.(Author)

International Isotopes Markets

Directory of Open Access Journals (Sweden)

Stanislaw Z. Zhiznin

2016-01-01

Full Text Available The paper studies world markets of stable and radioactive isotopes. Isotopes have found various applications in science, industry, agriculture and other sectors of the economy, but especially - in medicine. Nuclear medicine is developing intensively all over the world thanks to the success in the treatment of various diseases with the help of radioactive pharmaceuticals (radiopharmaceuticals. The article uses empirical data from a forecast study of the global radiopharmaceuticals market made in 2015 by a research company «Markets and Markets» for the European, North American and global markets. The paper also analyzes the statistical data on the global export and import of natural uranium, enriched and depleted uranium, plutonium, thorium and some stable isotopes of non-medical purposes, presented by a company «Trend economy» in 2014. Despite a unique industrial base for the production of isotopes created in the Soviet Union Russia occupies a modest position on the world market of nuclear medicine except for certain areas. More than 80% of isotopes, produced in USSR were consumed domestically, the export of the stable and radioactive isotopes was in equal proportions. Now the country's domestic radiopharmaceuticals market is poorly developed. To radically change the situation, it is necessary to carry out reforms that stimulate the development of nuclear medicine.

Current situation of International Organization for Standardization/Technical Committee 249 international standards of traditional Chinese medicine.

Science.gov (United States)

Liu, Yu-Qi; Wang, Yue-Xi; Shi, Nan-Nan; Han, Xue-Jie; Lu, Ai-Ping

2017-05-01

To review the current situation and progress of traditional Chinese medicine (TCM) international standards, standard projects and proposals in International Organization for Standardization (ISO)/ technical committee (TC) 249. ISO/TC 249 standards and standard projects on the ISO website were searched and new standard proposals information were collected from ISO/TC 249 National Mirror Committee in China. Then all the available data were summarized in 5 closely related items, including proposed time, proposed country, assigned working group (WG), current stage and classifification. In ISO/TC 249, there were 2 international standards, 18 standard projects and 24 new standard proposals proposed in 2014. These 44 standard subjects increased year by year since 2011. Twenty-nine of them were proposed by China, 15 were assigned to WG 4, 36 were in preliminary and preparatory stage and 8 were categorized into 4 fifields, 7 groups and sub-groups based on International Classifification Standards. A rapid and steady development of international standardization in TCM can be observed in ISO/TC 249.

International radiofrequency standards

International Nuclear Information System (INIS)

Lincoln, J.

2001-01-01

Of the various radiofrequency standards in use around the world, many are based on or similar to the Guidelines published by ICNIRP (The International Commission on Non-ionising Radiation Protection). This organisation is a working group operating in co-operation with the Environmental Health division of the World Health Organisation (WHO). This paper presents a very brief overview of current international standards, beginning with a summary of the salient points of the ICNIRP Guidelines. It should be remembered that these are guidelines only and do not exist as a separate standard. Copyright (2001) Australasian Radiation Protection Society Inc

Platinum stable isotope analysis of geological standard reference materials by double-spike MC-ICPMS.

Science.gov (United States)

Creech, J B; Baker, J A; Handler, M R; Bizzarro, M

2014-01-10

We report a method for the chemical purification of Pt from geological materials by ion-exchange chromatography for subsequent Pt stable isotope analysis by multiple-collector inductively coupled plasma mass spectrometry (MC-ICPMS) using a 196 Pt- 198 Pt double-spike to correct for instrumental mass bias. Double-spiking of samples was carried out prior to digestion and chemical separation to correct for any mass-dependent fractionation that may occur due to incomplete recovery of Pt. Samples were digested using a NiS fire assay method, which pre-concentrates Pt into a metallic bead that is readily dissolved in acid in preparation for anion-exchange chemistry. Pt was recovered from anion-exchange resin in concentrated HNO 3 acid after elution of matrix elements, including the other platinum group elements (PGE), in dilute HCl and HNO 3 acids. The separation method has been calibrated using a precious metal standard solution doped with a range of synthetic matrices and results in Pt yields of ≥90% with purity of ≥95%. Using this chemical separation technique, we have separated Pt from 11 international geological standard reference materials comprising of PGE ores, mantle rocks, igneous rocks and one sample from the Cretaceous-Paleogene boundary layer. Pt concentrations in these samples range from ca. 5 ng g -1 to 4 μg g -1 . This analytical method has been shown to have an external reproducibility on δ 198 Pt (permil difference in the 198 Pt/ 194 Pt ratio from the IRMM-010 standard) of ±0.040 (2 sd) on Pt solution standards (Creech et al., 2013, J. Anal. At. Spectrom. 28, 853-865). The reproducibility in natural samples is evaluated by processing multiple replicates of four standard reference materials, and is conservatively taken to be ca. ±0.088 (2 sd). Pt stable isotope data for the full set of reference materials have a range of δ 198 Pt values with offsets of up to 0.4‰ from the IRMM-010 standard, which are readily resolved with this technique. These

Isotopic analysis of uranium by thermoionic mass spectrometry

International Nuclear Information System (INIS)

Moraes, N.M.P. de.

1979-01-01

Uranium isotopic ratio measurements by thermoionic spectrometry are presented. Emphasis is given upon the investigation of the parameters that directly affect the precision and accuracy of the results. Optimized procedures, namely, chemical processing, sample loading on the filaments, vaporization, ionization and measurements of ionic currents, are established. Adequate statistical analysis of the data for the calculation of the internal and external variances and mean standard deviation are presented. These procedures are applied to natural and NBS isotopic standard uranium samples. The results obtained agree with the certified values within specified limits. 235 U/ 238 U isotopic ratios values determined for NBS-U500, and a series of standard samples with variable isotopic compositon, are used to calculate mass discrimination factor [pt

An inter-laboratory comparison of Si isotope reference materials

NARCIS (Netherlands)

Reynolds, B.C.; Aggarwal, J.; André, L.; Baxter, B.; Beucher, C.; Brzezinski, M.A.; Engström, E.; Georg, R.B.; Land, M.; Leng, M.J.; Opfergelt, S.; Rodushkin, I.; Sloane, H.J.; Van den Boorn, S.H.J.M.; Vroon, P.Z.; Cardinal, D.

2007-01-01

Three Si isotope materials have been used for an inter-laboratory comparison exercise to ensure reproducibility between international laboratories investigating natural Si isotope variations using a variety of chemical preparation methods and mass spectrometric techniques. These proposed standard

The International Standards Organisation offshore structures standard

International Nuclear Information System (INIS)

Snell, R.O.

1994-01-01

The International Standards Organisation has initiated a program to develop a suite of ISO Codes and Standards for the Oil Industry. The Offshore Structures Standard is one of seven topics being addressed. The scope of the standard will encompass fixed steel and concrete structures, floating structures, Arctic structures and the site specific assessment of mobile drilling and accommodation units. The standard will use as base documents the existing recommended practices and standards most frequently used for each type of structure, and will develop them to incorporate best published and recognized practice and knowledge where it provides a significant improvement on the base document. Work on the Code has commenced under the direction of an internationally constituted sub-committee comprising representatives from most of the countries with a substantial offshore oil and gas industry. This paper outlines the background to the code and the format, content and work program

International conference on isotopes in environmental studies - Aquatic Forum 2004. Book of extended synopses

International Nuclear Information System (INIS)

2004-01-01

The International Conference on Isotopes in Environmental Studies: AQUATIC FORUM 2004, organized by the International Atomic Energy Agency (IAEA) was held in Monte-Carlo, Monaco, 25-29 October 2004. The principal objective of the Conference was to review recent achievements in the use of isotopic techniques to study marine and terrestrial environmental processes, transport of contaminants in the aquatic environment, climate change, computer modelling of environmental processes, present state of the art of isotopic techniques, data validation and syntheses, and the development of geographical information systems. This publication contains the extended synopses of presentations at the Conference

International conference on isotopes in environmental studies - Aquatic Forum 2004. Book of extended synopses

Energy Technology Data Exchange (ETDEWEB)

NONE

2004-07-01

The International Conference on Isotopes in Environmental Studies: AQUATIC FORUM 2004, organized by the International Atomic Energy Agency (IAEA) was held in Monte-Carlo, Monaco, 25-29 October 2004. The principal objective of the Conference was to review recent achievements in the use of isotopic techniques to study marine and terrestrial environmental processes, transport of contaminants in the aquatic environment, climate change, computer modelling of environmental processes, present state of the art of isotopic techniques, data validation and syntheses, and the development of geographical information systems. This publication contains the extended synopses of presentations at the Conference.

Proceedings of 1. international symposium on applied isotope geochemistry (AIG-1)

International Nuclear Information System (INIS)

Aaberg, G.; Joergensen, E.B.

1993-09-01

The publication is a compilation of abstracts from the ''1. international symposium on applied isotope geochemistry (AIG-1)'' in Norway. The symposium was the first of its kind taking up different applications of most of the available isotopic systems and thus covered a wide range of topics from: 1) Water resources, hydrology, geomedicine and environmental problems, 2) Petroleum exploration and production, 3) Mineral exploration and 4) Analytical methods

Determination of plutonium in highly radioactive liquid waste by spectrophotometry using neodymium as an internal standard for safeguards analysis. Japan support program for agency safeguards (JASPAS) JC-19

International Nuclear Information System (INIS)

Taguchi, Shigeo; Surugaya, Naoki; Sato, Soichi; Kurosawa, Akira; Watahiki, Masaru; Hiyama, Toshiaki

2006-06-01

A spectrophotometric determination using neodymium as an internal standard was developed for safeguards verification analysis of plutonium in highly radioactive liquid waste which is produced by the reprocessing of spent nuclear fuel. The internal standard is used as a means to analyze plutonium and also to authenticate the instrument conditions. The method offers reduced sample preparation and analysis time compared to isotope dilution mass spectrometry. The sample was mixed with a known amount of internal standard. Subsequently, plutonium was quantitatively oxidized to Pu(VI) by the addition of Ce(IV) for spectrophotometry. Plutonium concentration was calculated from a relation between Nd(III)/Pu(VI) molar extinction coefficient ratio and their absorbance ratio. The relative expanded uncertainty of the repeated analysis (n=5) was 8.9% (coverage factor k=2) for a highly radioactive liquid waste sample (173 mg L -1 ). The determination limit was 6 mg L -1 (ten fold's the standard deviation). This method was validated through comparison experiments with isotope dilution mass spectrometry. The analytical results of plutonium in highly radioactive liquid waste using this method were agree well with values obtained using isotope dilution mass spectrometry. The proposed method can be applied to independent on-site safeguards analysis at the Tokai Reprocessing Plant. (author)

The international dimensions of nuclear safety standards

International Nuclear Information System (INIS)

Reed, J.M.

1992-01-01

The paper reviews the activities of the major international organisations in the field of nuclear safety standards; the International Atomic Energy Agency (IAEA), the OECD's Nuclear Energy Agency (NEA) and the Commission of the European Communities. Each organisation encourages the concept of international nuclear safety standards. After Chernobyl, there were calls for some form of binding international nuclear safety standards. Many Member States of IAEA accepted these Codes as a suitable basis for formulating their national safety standards, but the prevailing view was that voluntary compliance with the Codes was the preferred path. With few reactor vendors in a limited international market, the time may be approaching when an internationally licensable nuclear reactor is needed. Commonly accepted safety standards would be a prerequisite. The paper discusses the issues involved and the complexities of standards making in the international arena. (author)

Round robin analyses of hydrogen isotope thin films standards

Energy Technology Data Exchange (ETDEWEB)

Banks, J.C. E-mail: jcbanks@sandia.gov; Browning, J.F.; Wampler, W.R.; Doyle, B.L.; LaDuca, C.A.; Tesmer, J.R.; Wetteland, C.J.; Wang, Y.Q

2004-06-01

Hydrogen isotope thin film standards have been manufactured at Sandia National Laboratories for use by the materials characterization community. Several considerations were taken into account during the manufacture of the ErHD standards, with accuracy and stability being the most important. The standards were fabricated by e-beam deposition of Er onto a Mo substrate and the film stoichiometrically loaded with hydrogen and deuterium. To determine the loading accuracy of the standards two random samples were measured by thermal desorption mass spectrometry and atomic absorption spectrometry techniques with a stated combined accuracy of {approx}1.6% (1{sigma}). All the standards were then measured by high energy RBS/ERD and RBS/NRA with the accuracy of the techniques {approx}5% (1{sigma}). The standards were then distributed to the IBA materials characterization community for analysis. This paper will discuss the suitability of the standards for use by the IBA community and compare measurement results to highlight the accuracy of the techniques used.

International standards in mitigating trade risks.

Science.gov (United States)

Thiermann, A B

2011-04-01

This paper describes the role of the World Organisation for Animal Health (OIE), as a science-based and democratic standard-setting organisation that provides guidance on preventing the spread of animal diseases, including zoonoses, in international trade. The World Trade Organization is identified as the international institution with the legal power to encourage adherence to international standards and mediate trade disputes. The importance of assuring good governance and the credibility of national Veterinary Services through a process of official certification is identified as an essential component in the safety of trade. Private-public partnerships and the evolution of responsibilities are also identified as essential for the implementation of health guarantees such as compartmentalisation. The rapid emergence of private standards is described as a potential complement to the implementation of sanitary standards, as long as they are applied globally and in support of the OIE standards. Ultimately, the biggest challenge is for the international community to create the incentives and generate the political will for fair trade and for the universal recognition and application of the established international sanitary standards.

77 FR 43196 - Minimum Internal Control Standards and Technical Standards

Science.gov (United States)

2012-07-24

... NATIONAL INDIAN GAMING COMMISSION 25 CFR Parts 543 and 547 Minimum Internal Control Standards [email protected] . SUPPLEMENTARY INFORMATION: Part 543 addresses minimum internal control standards (MICS) for Class II gaming operations. The regulations require tribes to establish controls and implement...

Problems with the implementation of international standards for financial reporting and international audit standards

OpenAIRE

Dimitrova, Janka

2012-01-01

The International Financial Reporting Standards (IFRS) are designed for application in the financial reports with general purpose and the other financial reporting in all profit-oriented entities. The International Auditing Standards (IAS) are setting out the framework for carrying out the review process of financial reporting from entities referred to audit in order to verify the authenticity of the information and raising up the credibility of financial statements. Quality implementation...

International conference on isotopic and nuclear analytical techniques for health and environment. Unedited papers

International Nuclear Information System (INIS)

2004-01-01

The IAEA has been supporting nuclear and isotopic analytical techniques as part of its mandate to foster the peaceful uses of nuclear energy for many years. Nuclear analytical laboratories have been installed and upgraded through technical co-operation assistance in many laboratories of Member States. These techniques, including INAA, CRF, PIXE, stable isotopes and radioisotopes, α, β, γ spectrometry, Moessbauer spectrometry, etc., have been applied to a wide range of subjects with varying success. Nuclear analytical techniques, featuring some intrinsic quality control aspects, such as multi-nuclide analysis, frequently serve as 'reference methods' to crosscheck critical results. As nuclear properties of elements are targeted, matrix problems seem to be negligible. In light of its continued commitment and support, the IAEA organized the International Conference on Isotopic and Nuclear Analytical Techniques for Health and Environment. Out of 220 from 61 countries who applied for participation, 155 official participants and five observers from 47 countries were in attendance, with 67 from 32 developing countries and 21 from international organizations, including the World Health Organization. Eleven plenary sessions were held. Also conducted was a panel discussion on Human Capacity Development Needs in the Areas of Analytical Quality Control Services (AQCS), Radiochemistry and Nutrition. The scientific sessions were divided into several topics, which reflect some of the important activities of the IAEA's Department of Nuclear Sciences and Applications (NA): - Isotopic and nuclear techniques (general); - Metrology and quality assurance in nuclear measurements; - Nuclear analytical techniques for environmental monitoring; - Radioecology; - Environmental monitoring; - Radiological safety of food and water; - Methodological aspects of stable isotope techniques in health and environment; - Applications of isotopic techniques in health and environment; - New

CONVERGENCE OF INTERNATIONAL AUDIT STANDARDS AND AMERICAN AUDIT STANDARDS REGARDING SAMPLING

Directory of Open Access Journals (Sweden)

Chis Anca Oana

2013-07-01

Full Text Available Abstract: Sampling is widely used in market research, scientific analysis, market analysis, opinion polls and not least in the financial statement audit. We wonder what is actually sampling and how did it appear? Audit sampling involves the application of audit procedures to less than 100% of items within an account balance or class of transactions. Nowadays the technique is indispensable, the economic entities operating with sophisticated computer systems and large amounts of data. Economic globalization and complexity of capital markets has made possible not only the harmonization of international accounting standards with the national ones, but also the convergence of international accounting and auditing standards with the American regulations. International Standard on Auditing 530 and Statement on Auditing Standard 39 are the two main international and American normalized referentials referring to audit sampling. This article discusses the origin of audit sampling, mentioning a brief history of the method and different definitions from literature review. The two standards are studied using Jaccard indicators in terms of the degree of similarity and dissimilarity concerning different issues. The Jaccard coefficient measures the degree of convergence of international auditing standards (ISA 530 and U.S. auditing standards (SAS 39. International auditing standards and American auditing standards, study the sampling problem, both regulations presenting common points with regard to accepted sampling techniques, factors influencing the audit sample, treatment of identified misstatements and the circumstances in which sampling is appropriate. The study shows that both standards agree on application of statistical and non-statistical sampling in auditing, that sampling is appropriate for tests of details and controls, the factors affecting audit sampling being audit risk, audit objectives and population\\'s characteristics.

International symposium on isotope hydrology and integrated water resources management. Book of extended synopses

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

Scarcity of freshwater, degradation of its quality, and increasing demand has motivated ongoing concern in the international community for more effective utilization of freshwater resources. The IAEA's symposia on the use of isotope techniques in water resources development and management have become a recurrent event held every four years. They have provided an international forum for a comprehensive review of the present state-of-the-art and recent advances made in this specific field as well as a basis for delineation of further research and development needs. The year 2003 marks the 40th anniversary of the first IAEA water resources symposium. Increasing use of isotope techniques over the past four decades, in part due to efforts of IAEA, has enhanced availability and effective use of isotopes to address water resources management issues. The Symposium covers a multi-disciplinary spectrum of research and applications of isotope techniques. The participation of isotope specialists, hydrologists, hydrogeologists, geochemists, environmental scientists and water managers is welcomed. The Organizers further encourage the participation and contribution of graduate students in these fields. The major areas covered include: Water cycle processes in the atmosphere and hydrosphere, including surface water, groundwater, and watershed-based studies, age dating of young groundwaters, water, carbon and nutrient cycling processes at the land-ocean-atmosphere interface, recent advances in analytical techniques for isotope hydrology and field applications of isotopes in groundwater or surface water resources management. This book of synopses covers oral presentations and poster sessions.

EVALUATION OF DIFFERENT INTERNAL STANDARDS FOR ...

African Journals Online (AJOL)

internal standard addition method was evaluated with the variation in solution ... background emissions involved in generating accurate and reliable .... The most suitable atomic and ionic wavelengths (λ) for the internal standards and precious ..... spectral interferences occur and using validation parameters is currently ...

Novel isotopic N, N-Dimethyl Leucine (iDiLeu) Reagents Enable Absolute Quantification of Peptides and Proteins Using a Standard Curve Approach

Science.gov (United States)

Greer, Tyler; Lietz, Christopher B.; Xiang, Feng; Li, Lingjun

2015-01-01

Absolute quantification of protein targets using liquid chromatography-mass spectrometry (LC-MS) is a key component of candidate biomarker validation. One popular method combines multiple reaction monitoring (MRM) using a triple quadrupole instrument with stable isotope-labeled standards (SIS) for absolute quantification (AQUA). LC-MRM AQUA assays are sensitive and specific, but they are also expensive because of the cost of synthesizing stable isotope peptide standards. While the chemical modification approach using mass differential tags for relative and absolute quantification (mTRAQ) represents a more economical approach when quantifying large numbers of peptides, these reagents are costly and still suffer from lower throughput because only two concentration values per peptide can be obtained in a single LC-MS run. Here, we have developed and applied a set of five novel mass difference reagents, isotopic N, N-dimethyl leucine (iDiLeu). These labels contain an amine reactive group, triazine ester, are cost effective because of their synthetic simplicity, and have increased throughput compared with previous LC-MS quantification methods by allowing construction of a four-point standard curve in one run. iDiLeu-labeled peptides show remarkably similar retention time shifts, slightly lower energy thresholds for higher-energy collisional dissociation (HCD) fragmentation, and high quantification accuracy for trypsin-digested protein samples (median errors <15%). By spiking in an iDiLeu-labeled neuropeptide, allatostatin, into mouse urine matrix, two quantification methods are validated. The first uses one labeled peptide as an internal standard to normalize labeled peptide peak areas across runs (<19% error), whereas the second enables standard curve creation and analyte quantification in one run (<8% error).

Importance of international standards on hydrogen technologies

International Nuclear Information System (INIS)

Bose, T.K.; Gingras, S.

2001-01-01

This presentation provided some basic information regarding standards and the International Organization for Standardization (ISO). It also explained the importance of standardization activities, particularly ISO/TC 197 which applies to hydrogen technologies. Standards are established by consensus. They define the minimum requirements that will ensure that products and services are reliable and effective. Standards contribute to the elimination of technical barriers to trade (TBT). The harmonization of standards around the world is desirable in a free trade environment. The influence of the TBT on international standardization was discussed with particular reference to the objectives of ISO/TC 197 hydrogen technologies. One of the priorities for ISO/TC 197 is a hydrogen fuel infrastructure which includes refuelling stations, fuelling connectors, and storage technologies for gaseous and liquid hydrogen. Other priorities include an agreement between the International Electrotechnical Commission (IEC) and the ISO, in particular the IEC/TC 105 and ISO/TC 197 for the development of fuel cell standards. The international standards that have been published thus far include ISO 13984:1999 for liquid hydrogen, land vehicle fuelling system interface, and ISO 14687:1999 for hydrogen fuel product specification. Standards are currently under development for: liquid hydrogen; airport hydrogen fuelling facilities; gaseous hydrogen blends; basic considerations for the safety of hydrogen systems; gaseous hydrogen and hydrogen blends; and gaseous hydrogen for land vehicle filling connectors. It was concluded that the widespread use of hydrogen is dependent on international standardization

Spillover effects of international standards

DEFF Research Database (Denmark)

Trifkovic, Neda

Most studies focus on trade effects and organizational outcomes of international standards, neglecting the effect of standards on employees. Using a two-year matched firm–employee panel dataset, this paper finds that the application of standards improves work conditions in small and medium....... The study reveals unexpected benefits from certification, calling for higher investment in standards....

China and IEC international standardization activities

Institute of Scientific and Technical Information of China (English)

Su Zhongmin; Guo Chenguang

2006-01-01

@@ International Electrotechnical Commission (IEC), one of the currently worlswide largest and most authoritative international standardization organizations,is specialized in developing and promulgating international standards for the electric and electronic fields, which are widespread adopted through out the world and play an important role in the international trade of electric and electronic products. Moreover, according to the 2005 statistics by the World Bank, the population of countries participating in the IEC activities accounts for 92% of the world total and their trade volume accounts for 95% of the global total.

International standards and agreements in food irradiation

International Nuclear Information System (INIS)

Cetinkaya, N.

2004-01-01

The economies of both developed and developing countries have been effected by their exported food and agricultural products. Trading policies of food and agricultural products are governed by international agreement as well as national regulations. Trade in food and agricultural commodities may be affected by both principal Agreements within the overall World Trade Organization (WTO) Agreement, though neither specifically refers to irradiation or irradiated foods. The principal Agreements are the Technical Barriers to Trade (TBT) Agreement and the Sanitary and Phyto sanitary (SPS) Agreement. The SPS of the WTO requires governments to harmonize their sanitary and phyto sanitary measures on as wide basis as possible. Related standards, guidelines and recommendations of international standard setting bodies such as the Codex Alimentarius Commission (food safety); the International Plant Protection Convention (IPPC) (plant health and quarantine); and International Office of Epizootic (animal health and zoo noses) should be used in such a harmonization. International Standards for Phyto sanitary Measures (ISPM) no.18 was published under the IPPC by FAO (April 2003, Rome-Italy). ISPM standard provides technical guidance on the specific procedure for the application of ionizing radiation as a phyto sanitary treatment for regulated pests or articles. Moreover, Codex Alimentarius Commission, Codex General Standard for Irradiated Foods (Stand 106-1983) and Recommended International Code of Practice were first published in 1983 and revised in March 2003. Scope of this standard applies to foods processed by ionizing radiation that is used in conjunction with applicable hygienic codes, food standards and transportation codes. It does not apply to foods exposed to doses imparted by measuring instruments used for inspection purposes. Codex documents on Principles and Guidelines for the Import/Export Inspection and Certification of Foods have been prepared to guide international

Preparation of a multi-isotope plutonium AMS standard and preliminary results of a first inter-lab comparison

Energy Technology Data Exchange (ETDEWEB)

Dittmann, B.-A.; Dunai, T.J. [Institute of Geology and Mineralogy, University of Cologne, Greinstr. 4-6, 50939 Cologne (Germany); Dewald, A.; Heinze, S.; Feuerstein, C. [Institute of Nuclear Physics, University of Cologne, Zülpicher Str. 77, 50937 Cologne (Germany); Strub, E. [Division of Nuclear Chemistry, University of Cologne, Zülpicher Str. 45, 50674 Cologne (Germany); Fifield, L.K.; Froehlich, M.B.; Tims, S.G.; Wallner, A. [Department of Nuclear Physics, Research School of Physics & Engineering, Australian National University, Canberra ACT 2601 (Australia); Christl, M. [Laboratory of Ion Beam Physics, ETH Zurich, Otto-Stern-Weg 5, 8093 Zurich (Switzerland)

2015-10-15

The motivation of this work is to establish a new multi-isotope plutonium standard for isotopic ratio measurements with accelerator mass spectrometry (AMS), since stocks of existing solutions are declining. To this end, certified reference materials (CRMs) of each of the individual isotopes {sup 239}Pu, {sup 240}Pu, {sup 242}Pu and {sup 244}Pu were obtained from JRC IRMM (Joint Research Center Institute for Reference Materials and Measurements). These certified reference materials (IRMM-081a, IRMM-083, IRMM-043 and IRMM-042a) were diluted with nitric acid and mixed to obtain a stock standard solution with an isotopic ratio of approximately 1.0:1.0:1.0:0.1 ({sup 239}Pu:{sup 240}Pu:{sup 242}Pu:{sup 244}Pu). From this stock solution, samples were prepared for measurement of the plutonium isotopic composition by AMS. These samples have been measured in a round-robin exercise between the AMS facilities at CologneAMS, at the ANU Canberra and ETH Zurich to verify the isotopic ratio and to demonstrate the reproducibility of the measurements. The results show good agreement both between the different AMS measurements and with the gravimetrically determined nominal ratios.

Evaluation of online carbon isotope dilution mass spectrometry for the purity assessment of synthetic peptide standards

Energy Technology Data Exchange (ETDEWEB)

Díaz, Sergio Cueto; Ruiz Encinar, Jorge, E-mail: ruizjorge@uniovi.es; García Alonso, J. Ignacio, E-mail: jiga@uniovi.es

2014-09-24

Highlights: • Purity assessment of peptide standards applicable to any water soluble peptide. • Online {sup 13}C isotope dilution mass spectrometry. • Mass flow chromatogram from measured 44/45 isotope ratios. • Validation by the analysis of NIST 8327. - Abstract: We present a novel method for the purity assessment of peptide standards which is applicable to any water soluble peptide. The method is based on the online {sup 13}C isotope dilution approach in which the peptide is separated from its related impurities by liquid chromatography (LC) and the eluent is mixed post-column with a continuous flow of {sup 13}C-enriched sodium bicarbonate. An online oxidation step using sodium persulfate in acidic media at 99 °C provides quantitative oxidation to {sup 12}CO{sub 2} and {sup 13}CO{sub 2} respectively which is extracted to a gaseous phase with the help of a gas permeable membrane. The measurement of the isotope ratio 44/45 in the mass spectrometer allows the construction of the mass flow chromatogram. As the only species that is finally measured in the mass spectrometer is CO{sub 2}, the peptide content in the standard can be quantified, on the base of its carbon content, using a generic primary standard such as potassium hydrogen phthalate. The approach was validated by the analysis of a reference material (NIST 8327), and applied to the quantification of two commercial synthetic peptide standards. In that case, the results obtained were compared with those obtained using alternative methods, such as amino acid analysis and ICP-MS. The results obtained proved the value of the method for the fast, accurate and precise mass purity assignment of synthetic peptide standards.

Book of abstracts of the 3rd International conference and the 3rd International School for young scientists Interaction of hydrogen isotopes with structural materials. IHISM-07

International Nuclear Information System (INIS)

2007-01-01

The book involves abstracts of presentations at the 3rd International Conference and the 3rd International School for Young Scientists Interaction of Hydrogen Isotopes with Structural Materials (IHISM-07). The activities of Russian and foreign scientific centers associated with the use of hydrogen isotopes in power engineering, national economy and basic research are considered. The presentations cover the following areas: kinetics and interaction between hydrogen isotopes and solids including effects of radiogenic helium accumulation, hydrides and hydride transformations; structural transformations and mechanical properties; equipment and research techniques [ru

Russian seismic standards and demands for equipment and their conformity with international standards

International Nuclear Information System (INIS)

Kaznovsky, S.; Ostretsov, I.

1993-01-01

The principle regulations of standard documents concerning seismic safety of NPPs and demands for reactor equipment conformity with international standards are presented in this report. General state of NPP safety standards is reviewed, with a special emphasis on the state of seismic design standards for NPP equipment and piping. Russian standards documents on seismic resistance of NPPs and requirements are compared to international ones

International standards and agreements in food irradiation

International Nuclear Information System (INIS)

Cetinkaya, N.

2004-01-01

Full text: The economies of both developed and developing countries have been effected by their exported food and agricultural products. Trading policies of food and agricultural products are governed by international agreement as well as national regulations. Trade in food and agricultural commodities may be affected by both principal Agreements within the overall World Trade Organization (WTO) Agreement, though neither specifically refers to irradiation or irradiated foods. The principal Agreements are the Technical Barriers to Trade (TBT) Agreement and the Sanitary and Phyto sanitary (SPS) Agreement. The SPS of the WTO requires governments to harmonize their sanitary and phyto sanitary measures on as wide basis as possible. Related standards, guidelines and recommendations of international standard setting bodies such as the Codex Alimentarius Commission (food safety); the International Plant Protection Convention (IPPC) (plant health and quarantine); and International Office of Epizootic (animal health and zoo noses) should be used in such a harmonization. International Standards for Phyto sanitary Measures (ISPM) no.18 was published under the IPPC by FAO (April 2003, Rome-Italy). ISPM standard provides technical guidance on the specific procedure for the application of ionizing radiation as a phyto sanitary treatment for regulated pests or articles. Moreover, Codex Alimentarius Commission, Codex General Standard for Irradiated Foods (Stand 106-1983) and Recommended International Code of Practice were first published in 1983 and revised in March 2003. Scope of this standard applies to foods processed by ionizing radiation that is used in conjunction with applicable hygienic codes, food standards and transportation codes. It does not apply to foods exposed to doses imparted by measuring instruments used for inspection purposes. Codex documents on Principles and Guidelines for the Import/Export Inspection and Certification of Foods have been prepared to guide

International standardization in the field of environment

International Nuclear Information System (INIS)

Lehmann, K.

1991-01-01

The ISO (International Organization for Standardization) is an international federation of national standards bodies. Its activities increasingly take health and environmental effects into account; in the future, standardization will also focus on identification systems that could facilitate recycling and proper disposal. Three technical committees in particular are concerned with standardization as it relates to air, water and soil quality. Other ISO work concerns product-oriented standardization, e.g. in the fields of fire protection equipment, refrigeration, thermal insulation, fibre-reinforced cement, and material and equipment used in the petroleum and natural gas industries. (author)

The political economy of international accounting standards

NARCIS (Netherlands)

Perry, J.; Nolke, A.

2006-01-01

On 1 January 2005, all stock exchange listed companies in the European Union (EU) began using International Financial Reporting Standards (IFRS) written by the International Accounting Standards Board (IASB). This article argues that the IASB's introduction of fair value accounting reflects and

Report on the intercomparison for the isotope standards limestone KH 2 and polyethylene foil PEF 1

International Nuclear Information System (INIS)

Gerstenberger, H.; Herrmann, M.

1983-01-01

The isotope abundance of 13 C and 18 O of a carbonate was measured by an intercomparison in order to create a new working standard for the mass spectrometric determination of isotopic variations in natural materials. For the same purpose a polyethylene was subjected an intercomparison and the abundance of 13 C and D has been determined. (author)

Developing and enforcing internal information systems standards: InduMaker’s Standards Management Process

Directory of Open Access Journals (Sweden)

Claudia Loebbecke

2016-01-01

Full Text Available It is widely agreed that standards provide numerous benefits when available and enforced. Company-internal Information Systems (IS management procedures and solutions, in the following coined IS ‘standards’, allow for harmonizing operations between company units, locations and even different service providers. However, many companies lack an organized process for defining and managing internal IS standards, which causes uncertainties and delays in decision making, planning, and design processes. In this case study of the globally operating InduMaker (anonymized company name, an established manufacturing supplier, we look into the company-internal management of IS standards. Theoretically grounded in the organizational and IS-focused literature on business process modelling and business process commoditization, we describe and investigate InduMaker’s newly developed Standard Management Process (SMP for defining and managing company-internal business and IS standards, with which the multinational pursues offering clear answers to business and IT departments about existing IS standards, their degree of obligation, applicability, and scope at any time.

National and International Standardization (International Organization for Standardization and European Committee for Standardization Relevant for Sustainability in Construction

Directory of Open Access Journals (Sweden)

Renata Morbiducci

2010-12-01

Full Text Available Sustainability in construction has a short history in terms of principles, standardizations and applications. From the Brundtland Report “Our Common Future”, a new vision of the resource deficits, climate impacts and the social responsibility gave growth to the idea of sustainability also in design and construction. Consequently, in around 2000, the international and national organizations for standardization started to develop standards for the application of sustainable principles. This paper gives an overview of existing and planned standards, and examples on how to use them as a framework for the development of methods and tools for assessment.

Nuclear Data Center International Standard Towards TSO Initiative

International Nuclear Information System (INIS)

Raja Murzaferi Raja Moktar; Mohd Fauzi Haris; Siti Nurbahyah Hamdan

2011-01-01

Nuclear Data Center is the main facility for Nuclear Malaysia Agency IT infrastructure comprising of main critical servers, research and operational data storage, HPC-clusters system and vital network core equipment. In recent years, international body such as TIA-Telecommunication Industry Association and Up time Institute have came out with proper international data center standards in order to ensure data center operation on achieving maximum operational up time and minimal downtime. The standard are currently being rated as tier level ranging from Data Center tier I up to tier IV, differentiate by facility standard and up time/ downtime percentage ratio. This paper will discuss Nuclear Data Center adopting international standards in supporting Nuclear Malaysia TSO initiative thus ensuring the critical core component of agency IT services availability and further more International standard recognitions. (author)

Towards an international address standard

CSIR Research Space (South Africa)

Coetzee, S

2008-02-01

Full Text Available in a better user experience. Standards compliance allows for the separation of concerns: HTML for content, Cascading Style Sheets (CSS) for presentation and JavaScript for dynamic behaviour. Standards compliant documents are also...) and cascading style sheets through CSS (CSS n.d.), whilst the JavaScript specification has been standardised by Ecma International (another standards organisation for information and communication systems), in the form of EcmaScript (Ecma...

The International harmonisation process of Accounting Standards

OpenAIRE

Fritz, Susanne; Lämmle, Christina

2003-01-01

Background: Growth in international trade and capital flows has triggered a rising economic integration. Because of these developments there has been an international homogenising effect upon many customs, practices and institutions. In business life it led among other things to a desire to harmonise Accounting Standards among countries. Purpose: Our purpose is to answer the question: What is the international harmonisation process of Accounting Standards, what is its status quo and how impo...

Observations on International Labor Standards and Trade

OpenAIRE

Alan B. Krueger

1996-01-01

This paper reviews the theoretical arguments for and against linking international labor standards to trade. Based on theory alone it is difficult to generalize about the effect of labor standards on efficiency and equity. Some economists have argued that international labor standards are merely disguised protectionism. An evaluation of determinants of support for legislation that would ban imports to the United States of goods made with child labor provides little support for the prevailing ...

PIDIE, plutonium isotopic determination inter-comparison exercise

International Nuclear Information System (INIS)

Harry, R.J.S.

1990-07-01

PIDIE (Plutonium Isotopic Determination Inter-comparison Exercise) is one of the projects of the ESARDA Working Group on Techniques and Standards for Non-Destructive Analysis. PIDIE is placed against the historical background of the general development of international standards. Its results are also reviewed in the light of the original purpose of the project. Sets of seven sealed Pu samples of different isotopic composition, each containing 0,45 grammes, were sent to the 9 participating laboratories for three separate determinations of the unknown isotopic composition, to investigate error sources and , if possible to improve the knowledge of γ-emission probabilities. An additional question was to examine the possible improvement of such measurements using reference samples. No important bias has been observed in the results of this inter-comparison. The apparent improvement in the precision and accuracy of the result seems to arise from both better equipment and more elaborate spectrum evaluation methods. (author). 39 refs.; 1 fig.; 5 tabs

Housekeeping genes as internal standards: use and limits.

Science.gov (United States)

Thellin, O; Zorzi, W; Lakaye, B; De Borman, B; Coumans, B; Hennen, G; Grisar, T; Igout, A; Heinen, E

1999-10-08

Quantitative studies are commonly realised in the biomedical research to compare RNA expression in different experimental or clinical conditions. These quantifications are performed through their comparison to the expression of the housekeeping gene transcripts like glyceraldehyde-3-phosphate dehydrogenase (G3PDH), albumin, actins, tubulins, cyclophilin, hypoxantine phsophoribosyltransferase (HRPT), L32. 28S, and 18S rRNAs are also used as internal standards. In this paper, it is recalled that the commonly used internal standards can quantitatively vary in response to various factors. Possible variations are illustrated using three experimental examples. Preferred types of internal standards are then proposed for each of these samples and thereafter the general procedure concerning the choice of an internal standard and the way to manage its uses are discussed.

International Standards for Neurological Classification of Spinal Cord Injury

DEFF Research Database (Denmark)

Kirshblum, S C; Biering-Sorensen, F; Betz, R

2014-01-01

The International Standards for the Neurological Classification of Spinal Cord Injury (ISNCSCI) is routinely used to determine the levels of injury and to classify the severity of the injury. Questions are often posed to the International Standards Committee of the American Spinal Injury Associat......The International Standards for the Neurological Classification of Spinal Cord Injury (ISNCSCI) is routinely used to determine the levels of injury and to classify the severity of the injury. Questions are often posed to the International Standards Committee of the American Spinal Injury...

International Electrotechnical Commission standards and French material control standards

International Nuclear Information System (INIS)

Furet, J.; Weill, J.

1978-01-01

There are reported the international standards incorporated into the IEC Subcommitee 45 A (Nuclear Reactor Instrumentation) and the national standards elaborated by the Commissariat a l'Energie Atomique, CEA, Group of normalized control equipment, the degree of application of those being reported on the base design, call of bids and exploitation of nuclear power plants. (J.E. de C)

The International Atomic Energy Agency circulation of laboratory air standards for stable isotope comparisons: Aims, preparation and preliminary results

International Nuclear Information System (INIS)

Allison, C.E.; Francey, R.J.; Steele, L.P.

2002-01-01

Ten air standards in high-pressure aluminium cylinders were prepared, covering a specified range of CO 2 concentration and δ 13 C and δ 18O isotopic composition, to be used for laboratory intercomparisons with the primary aim of merging global atmospheric CO 2 δ 13 C data sets. After establishing the stability of the standards, five were circulated between four laboratories with established high precision global monitoring networks to quantify differences between the measurement scales used in the laboratories. Measurements of CO 2 concentration in three of the four laboratories showed agreement to better than 0.2 ppm for the five standards. Measurements of N 2 O concentration reported by three of the laboratories agreed to better than 3 ppb after correction for known scaling factor differences, but a fourth laboratory reported results for two cylinders lower by about 20 ppb, contributing a δ 13 C uncertainty of about 0.012 per mille for these two cylinders. The reported measurements of the δ 13 C and δ 18O of CO 2 extracted from the air in the five standards showed large offsets between the laboratories of up to 0.1 per mille in δ 13 C and up to 1 per mille in δ 18O . Analysis of the results shows that about 40% of the offsets arises from differences in the procedures used in each laboratory to calculate the δ 13 C and δ 18 O values from the raw measurements and that the remainder arises from the pre-concentration step. Using one of the circulated standards to 'normalise' the others removes most of the inter-laboratory differences but there remains a non-linear response in one or more laboratories. The differences in δ 13 C that remain after normalisation are larger than the target precision of 0.01 per mille. (author)

Radiation safety: New international standards

International Nuclear Information System (INIS)

Gonzalez, A.J.

1994-01-01

This article highlights an important result of this work for the international harmonization of radiation safety: specifically, it present an overview of the forthcoming International Basic Safety Standards for Protection Against Ionizing Radiation and for the Safety of Radiation Sources - the so-called BSS. They have been jointly developed by six organizations - the Food and Agriculture Organization of the United Nations (FAO), the International Atomic Energy Agency (IAEA), the International Labour Organization (ILO), the Nuclear Energy Agency of the Organization for Economic Co-operation and Development (NEA/OECD), the Pan American Health Organization (PAHO), and the World Health Organization (WHO)

Approach for domestic preparation of standard material (LSD spike) for isotope dilution mass spectrometry

International Nuclear Information System (INIS)

Ishikawa, Fumitaka; Sumi, Mika; Chiba, Masahiko; Suzuki, Toru; Abe, Tomoyuki; Kuno, Yusuke

2008-01-01

The accountancy analysis of the nuclear fuel material at Plutonium Fuel Development Center of JAEA is performed by isotope dilution mass spectrometry (IDMS; Isotope Dilution Mass Spectrometry). IDMS requires the standard material called LSD spike (Large Size Dried spike) which is indispensable for the accountancy in the facilities where the nuclear fuel materials are handled. Although the LSD spike and Pu source material have been supplied from foreign countries, the transportation for such materials has been getting more difficult recently. This difficulty may affect the operation of nuclear facilities in the future. Therefore, research and development of the domestic LSD spike and base material has been performed at JAEA. Certification for such standard nuclear materials including spikes produced in Japan is being studied. This report presents the current status and the future plan for the technological development. (author)

International Financial Reporting Standards

DEFF Research Database (Denmark)

Pontoppidan, Caroline Aggestam

2011-01-01

The advance of International Financial Reporting Standards (IFRS) across the globe has accelerated over the last few years. This is placing increasing demands on educators to respond to these changes by an increased focus on IFRS in the curricula of accounting students. This paper reviews a range...

The use of a xylosylated plant glycoprotein as an internal standard accounting for N-linked glycan cleavage and sample preparation variability.

Science.gov (United States)

Walker, S Hunter; Taylor, Amber D; Muddiman, David C

2013-06-30

Traditionally, free oligosaccharide internal standards are used to account for variability in glycan relative quantification experiments by mass spectrometry. However, a more suitable internal standard would be a glycoprotein, which could also control for enzymatic cleavage efficiency, allowing for more accurate quantitative experiments. Hydrophobic, hydrazide N-linked glycan reagents (both native and stable-isotope labeled) are used to derivatize and differentially label N-linked glycan samples for relative quantification, and the samples are analyzed by a reversed-phase liquid chromatography chip system coupled online to a Q-Exactive mass spectrometer. The inclusion of two internal standards, maltoheptaose (previously used) and horseradish peroxidase (HRP) (novel), is studied to demonstrate the effectiveness of using a glycoprotein as an internal standard in glycan relative quantification experiments. HRP is a glycoprotein containing a xylosylated N-linked glycan, which is unique from mammalian N-linked glycans. Thus, the internal standard xylosylated glycan could be detected without interference to the sample. Additionally, it was shown that differences in cleavage efficiency can be detected by monitoring the HRP glycan. In a sample where cleavage efficiency variation is minimal, the HRP glycan performs as well as maltoheptaose. Because the HRP glycan performs as well as maltoheptaose but is also capable of correcting and accounting for cleavage variability, it is a more versatile internal standard and will be used in all subsequent biological studies. Because of the possible lot-to-lot variation of an enzyme, differences in biological matrix, and variable enzyme activity over time, it is a necessity to account for glycan cleavage variability in glycan relative quantification experiments. Copyright © 2013 John Wiley & Sons, Ltd.

Asset Accounting According to National and International Standards

OpenAIRE

Karina Utenkova

2014-01-01

The Article overviews the issues of complying National Accounting Standards at the enterprises of Ukraine with International Financial Reporting Standards. Key provisions of national and international standards governing the accounting of fixed assets (NP(S)A 7 'Property, Plant, Equipment', IFRS 16 'Fixed Assets') have been analyzed. It has been found that the list of PPE regulated by both accounting standard frameworks is not identical. Specifics of fixed assets recognition, their classifica...

International standards, Agreements and Policy of food Irradiation

International Nuclear Information System (INIS)

Roberts, P.B.

1997-01-01

There are few internationally recognised standards and agreements related to irradiated foods. Codex Alimentarius has its General standard for Irradiated foods. This sets standards for the production of irradiated foods that are safe and nutritionally adequate. Guidelines for the proper processing of foods by irradiation are covered in the Codex Recommended International Code of Practice for the Operation of Radiation Facilities Used for the Treatment of Food. For irradiation as a quarantine treatment for fruit, vegetables and other plants, the relevant international organization is the International Plant Protection Convention (IPPC), IPPC has no standards or guidelines for irradiation treatments. However, regional organizations within IPPC are moving towards recognition of irradiation as a technically viable and effective method of insect disinfestation. Especially notable are actions within the North American Plant Protection Organisation (NAPPO). NAPPO has endorsed a standard on the use of irradiation as a quarantine treatment. Other speakers have provided considerable detail on the Codex standard and on the situation with regard to quarantine issues. In this talk I will concentrate on irradiated foods as commodities that will be traded internationally in increasing amounts as we approach the next century. International trade is governed by bilateral arrangements. However, these arrangements should be consistent with the overarching multilateral agreements of the World trade Organization (WTO). The WTO Agreements do not refer directly to irradiation or irradiated foods. However, in this talk I will try to interpret the implications of the Agreements for trade in irradiated food. (Author)

International standards, Agreements and Policy of food Irradiation

Energy Technology Data Exchange (ETDEWEB)

Roberts, P.B. [Industrial and Biological Section. Institute of Geological and Nuclear Science. P.O. Box 31. Lower Hutt (New Zealand)

1997-12-31

There are few internationally recognised standards and agreements related to irradiated foods. Codex Alimentarius has its General standard for Irradiated foods. This sets standards for the production of irradiated foods that are safe and nutritionally adequate. Guidelines for the proper processing of foods by irradiation are covered in the Codex Recommended International Code of Practice for the Operation of Radiation Facilities Used for the Treatment of Food. For irradiation as a quarantine treatment for fruit, vegetables and other plants, the relevant international organization is the International Plant Protection Convention (IPPC), IPPC has no standards or guidelines for irradiation treatments. However, regional organizations within IPPC are moving towards recognition of irradiation as a technically viable and effective method of insect disinfestation. Especially notable are actions within the North American Plant Protection Organisation (NAPPO). NAPPO has endorsed a standard on the use of irradiation as a quarantine treatment. Other speakers have provided considerable detail on the Codex standard and on the situation with regard to quarantine issues. In this talk I will concentrate on irradiated foods as commodities that will be traded internationally in increasing amounts as we approach the next century. International trade is governed by bilateral arrangements. However, these arrangements should be consistent with the overarching multilateral agreements of the World trade Organization (WTO). The WTO Agreements do not refer directly to irradiation or irradiated foods. However, in this talk I will try to interpret the implications of the Agreements for trade in irradiated food. (Author)

Isotopes in environmental studies - Aquatic Forum 2004. Proceedings of an international conference. Unedited papers

International Nuclear Information System (INIS)

2006-01-01

A better understanding of key processes in the aquatic environment, responsible for its future development and its protection, were at the forefront of the IAEA's International Conference on Isotopes in Environmental Studies - AQUATIC FORUM 2004 convened in Monaco from 25 to 29 October 2004, which was the most important gathering of the year of isotope environmental scientists. Over 320 experts from 60 IAEA Member States and 6 international organizations delivered 185 oral presentations in 6 plenary and 31 parallel sessions and made 130 poster presentations. The conference reviewed the present state of the art isotopic methods for investigation of the aquatic environment. The main conference subjects considered were: (i) behaviour, transport and distribution of isotopes in the aquatic environment; (ii) climate change studies using isotopic records in the marine environment; (iii) groundwater dynamics, modelling and management of freshwater sources; (iv) important global projects, such as WOCE, WOMARS, SHOTS, GEOTRACES; (v) joint IAEA-UNESCO submarine groundwater investigations in the Mediterranean Sea, the Southwest Atlantic and Pacific Oceans; (vi) new trends in radioecological investigations, concentrating on the protection of marine biota against radioactive contamination; (vii) transfers in analytical technologies from bulk analyses to particle and compound specific analyses of environmental samples; (viii) development of new isotopic techniques, such as AMS and ICPMS, and their successful applications in environmental studies; and many other exciting topics which were presented and discussed during the Conference. Four workshops were held simultaneously: - ATOMS-Med Workshop - development of a project proposal for oceanographic investigations in the Eastern Mediterranean. - El Nino - Research Co-ordination Meeting of the new IAEA Coordinated Research Project investigating climate change using isotopic records in the marine environment. - CELLAR Workshop

Isotopic dependence of the fragments' internal temperatures determined from multifragment emission

Science.gov (United States)

Souza, S. R.; Donangelo, R.

2018-05-01

The internal temperatures of fragments produced by an excited nuclear source are investigated by using the microcanonical version of the statistical multifragmentation model, with discrete energy. We focus on the fragments' properties at the breakup stage, before they have time to deexcite by particle emission. Since the adopted model provides the excitation energy distribution of these primordial fragments, it allows one to calculate the temperatures of different isotope families and to make inferences about the sensitivity to their isospin composition. It is found that, due to the functional form of the nuclear density of states and the excitation energy distribution of the fragments, proton-rich isotopes are hotter than neutron-rich isotopes. This property has been taken to be an indication of earlier emission of the former from a source that cools down as it expands and emits fragments. Although this scenario is incompatible with the prompt breakup of a thermally equilibrated source, our results reveal that the latter framework also provides the same qualitative features just mentioned. Therefore they suggest that this property cannot be taken as evidence for nonequilibrium emission. We also found that this sensitivity to the isotopic composition of the fragments depends on the isospin composition of the source, and that it is weakened as the excitation energy of the source increases.

INTERNATIONAL FINANCIAL REPORTING STANDARDS AND ...

African Journals Online (AJOL)

PUBLICATIONS1

across borders led many economies to adopt the. International ... Keywords: Reporting Standards, Value, Relevance, Earnings, Management ..... nal of Applied Economics and Business Re- search ... accounting in emerging markets: Evidence.

The 11th International ICIT Conference Progress in Cryogenics and Isotopes Separation. Proceedings

International Nuclear Information System (INIS)

Stefanescu, Ioan

2005-01-01

The proceedings of the 11th International ICIT Conference Progress in Cryogenics and Isotopes Separation held in Caciulata, Romania on 12-14 October 2005 contain plenary lectures (6 papers) and 6 sections addressing the following subject matters: Section 1. Stable Isotopes Physics. Technologies and Applications (5 papers); Section 2. Science and Materials Engineering (11 papers); Section 3. Nuclear Power (21 papers); Section 4. Hydrogen and Fuel Cells (7 papers); Section 5. Environmental Protection. Industrial Risk (10 papers); Section 6. Laboratory Analysis Methods (10 papers). Twenty two papers are available in abstract form only and full text entered the corresponding records

International Organization for Standardization (ISO) 15189.

Science.gov (United States)

Schneider, Frank; Maurer, Caroline; Friedberg, Richard C

2017-09-01

The College of American Pathologists (CAP) offers a suite of laboratory accreditation programs, including one specific to accreditation to the international organization for standardization (ISO) 15189 standard for quality management specific to medical laboratories. CAP leaders offer an overview of ISO 15189 including its components, internal audits, occurrence management, document control, and risk management. The authors provide a comparison of its own ISO 15189 program, CAP 15189, to the CAP Laboratory Accreditation Program. The authors conclude with why laboratories should use ISO 15189. © The Korean Society for Laboratory Medicine.

Effects of national accounting standards convergence to international accounting standards on foreign direct investment

Directory of Open Access Journals (Sweden)

Asieh Farazandehnia

2015-09-01

Full Text Available One of the most important factors on attracting foreign investors to invest on Tehran Stock Exchange is to have transparent accounting rules and regulations. When there are some consistency between national accounting standards and international accounting standards, we may, at least, expect foreign investors to have better understanding on financial statements. In 2006, there were some changes on Iranian national accounting standards in an attempt to make them closer to international accounting standards. In this study, we select the information of 153 firms five years before and after this regulation and study the effect of convergence from national accounting standards to international accounting standards on foreign direct investment. Using some statistical tests, the study has determined that there was no meaningful relationship between foreign direct investment before and after change on accounting standards. In addition, there was no difference on the information quality before and after change on accounting standards. However, there was some meaningful relationship between the information quality and foreign direct investment.

46 CFR 108.503 - Relationship to international standards.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Relationship to international standards. 108.503 Section 108.503 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) A-MOBILE OFFSHORE DRILLING UNITS DESIGN AND EQUIPMENT Lifesaving Equipment § 108.503 Relationship to international standards. For...

46 CFR 133.03 - Relationship to international standards.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Relationship to international standards. 133.03 Section 133.03 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OFFSHORE SUPPLY VESSELS LIFESAVING SYSTEMS General § 133.03 Relationship to international standards. This subpart and subpart B of...

The 12th International ICIT Conference Progress in Cryogenics and Isotopes Separation. Proceedings

International Nuclear Information System (INIS)

Stefanescu, Ioan

2006-01-01

The proceedings of the 12th International ICIT Conference Progress in Cryogenics and Isotopes Separation held in Caciulata, Romania on 25-27 October 2006 contain plenary lectures (11 papers) and 7 sections addressing the following subject matters: Section 1. Stable Isotopes Physics. Technologies and Applications (6 papers); Section 2. Cryogenics Technologies and Equipment (6 papers); Section 3. Science and Materials Engineering (18 papers); Section 4. Nuclear Power (17 papers); Section 5. Hydrogen and Fuel Cells (14 papers); Section 6. Environmental Protection. Industrial Risk (14 papers); Section 7. Laboratory Analysis Methods (13 papers). A number of 40 papers are available in abstract form only and accordingly full text entered the corresponding records

Mass spectrometric analysis of stable carbon isotopes in abiogenic and biogenic natural compounds

International Nuclear Information System (INIS)

Sajjad, M.I.; Ahmed, M.; Tasneem, M.A.; Khan, I.A.; Latif, Z.

1989-07-01

This report describes the general methodology of sup/13/ carbon analysis on mass spectrometer and various preparation systems developed for conversion of samples into isotopically non-fractionated and purified carbon dioxide. Laboratory standards required for sup/13/ C analysis have been calibrated against international standards. The reproducibility/accuracy of sample preparation and analysis on mass spectrometer for sup/13/ C or sup/12/ C measurement is well within the internationally acceptable limits. (author)

Digital forensic standards: international progress

CSIR Research Space (South Africa)

Grobler, MM

2010-05-01

Full Text Available With the explosion of digital crime, digital forensics is more often applied. The digital forensic discipline developed rather rapidly, but up to date very little international standardization with regard to processes, procedures or management has...

International aspects of isotopes and radiation development and use

International Nuclear Information System (INIS)

Fowler, E.E.

1978-01-01

Radioisotopes have touched the daily lives of people throughout the world very profoundly and productively. This occurs in medicine, agriculture, industry and research. The International Atomic Energy Agency takes responsibility to assure that the full benefits of this atomic energy development are available to every country, and greatest effort is directed toward increased use of and increased benefits from radioisotopes in developing countries. The objective of the Agency is to accelerate and enlarge the contribution of atomic energy to peace, health and prosperity throughout the world, and in order to attain this objective, the Agency enters into research agreements, awards contracts, and provides technical assistance and other services to the institutions in member states. Moreover, it fosters the exchange of informations through conferences, symposia, seminars and technical committees, as well as the exchange and training of scientists and experts in this field. The Agency is organized into five departments to execute its principal functions: administration, safeguards, technical operations, technical assistance and publications, and research and isotopes. The major activities of the Agency in radioisotope production, stable isotope application, chemical problems in fission and fusion reactors, radiation preservation of foods and others are discussed. (Kako, I

Implementation of International Standards in Russia's Foreign Trade Statistics

Directory of Open Access Journals (Sweden)

Natalia E. Grigoruk

2015-01-01

Full Text Available The article analyzes the basic documents of international organizations in recent years, which have become the global standard for the development and improvement of statistics of foreign economic relations of most countries, including the Russian Federation. The article describes the key features of the theory and practice of modern foreign trade statistics in Russia and abroad, with an emphasis on the methodological problems of its main parts - the external trade statistics. It shows their interpretation in the most recent recommendations by UN statistical apparatus and other international organizations; considers a range of problems associated with the implementation of the national statistical practices of countries, including Russia and the countries of the Customs Union, the main international standard of foreign trade statistics - UN document "International Merchandise Trade Statistics". The main attention is paid to methodological issues such as: the criteria for selecting the objects of statistical accounting in accordance with international standards, quantitative and cost parameters of foreign trade statistics, statistical methods and estimates of commodity exports and imports, the problems of comparability of data; to a comparison of international standards in 2010 with documents on key precursor methodology of foreign trade statistics, characterized by the practice of introducing these standards in the foreign trade statistics of Russia and the countries of the Customs Union. The article analyzes the content given in the official statistical manuals of Russia foreign trade and foreign countries, covers the main methodological problems of World Trade in conjunction with the major current international statistical standards - System of National Accounts, Manual on Statistics of International Trade in Services and other documents; provides specific data describing the current structure of Russian foreign trade and especially its

EPA STANDARDS NETWORK FACT SHEET: ISO 14000: INTERNATIONAL ENVIRONMENTAL MANAGEMENT STANDARDS

Science.gov (United States)

This flyer provides an overview of the ISO 14000 series of International standards, supplying a brief history, structure of the Technical Committee (TC) 207, structure of the U.S. Technical Advisory Group (TAG) to ISO TC-207, status of the Standards development as of June 1997, w...

Ultratrace Uranium Fingerprinting with Isotope Selective Laser Ionization Spectrometry

International Nuclear Information System (INIS)

Ziegler, Summer L.; Bushaw, Bruce A.

2008-01-01

Uranium isotope ratios can provide source information for tracking uranium contamination in a variety of fields, ranging from occupational bioassay to monitoring aftereffects of nuclear accidents. We describe the development of Isotope Selective Laser Ionization Spectrometry (ISLIS) for ultratrace measurement of the minor isotopes 234U, 235U, and 236U with respect to 238U. Optical isotopic selectivity in three-step excitation with single-mode continuous wave lasers is capable of measuring the minor isotopes at relative abundances below 1 ppm, and is not limited by isobaric interferences such as 235UH+ during measurement of 236U. This relative abundance limit approaches the threshold for measurement of uranium minor isotopes with conventional mass spectrometry, typically 10-7, but without mass spectrometric analysis of the laser-created ions. Uranyl nitrate standards from an international blind comparison were used to test analytical performance for different isotopic compositions and with quantities ranging from 11 ng to 10 (micro)g total uranium. Isotopic ratio determination was demonstrated over a linear dynamic range of 7 orders of magnitude with a few percent relative precision and detection limits below 500 fg for the minor isotopes

ISO: international standards development for nuclear technology

International Nuclear Information System (INIS)

Becker, K.

1981-01-01

The importance of internationally recognized standards for nuclear technology and safety is rapidly increasing for technical as well as economical and political reasons such as public acceptance and nuclear technology transfer to developing countries. The need for such standards is also evident because of the large number of nuclear installations sited close to international borders, and the export of nuclear installations from relatively few supplier countries to a large number of user countries. It is the purpose of this report to describe briefly the history, organizational structures and procedures, goals, accomplishments, problems, and future needs of the relevant activities of the International Organization for Standardization (ISO). ISO is composed of the partly governmental, partly non-governmental national standards bodies of 86 countries including China. The work of its Technical Committee (TC) 85 'Nuclear Energy' is mostly concerned with industrial applications, contractual aspects and international communication, for the benefit of both developed and developing countries. It works in close liaison with IAEA, which develops Codes and Guides addressed mainly to the regulatory aspects of nuclear power plants in developing countries. ISO/TC 85 has four sub-committees dealing with: (a) Terminology, Definitions, Units and Symbols (Secretariat USA, four working groups (WGs)); (b) Radiation Protection (Secretariat France, ten WGs); (c) Power Reactor Technology (Secretariat Sweden, nine WGs); (d) Nuclear Fuel Technology (Secretariat F.R. Germany, seven WGs). (author)

A kinematic-based methodology for radiological protection: Runoff analysis to calculate the effective dose for internal exposure caused by ingestion of radioactive isotopes

Science.gov (United States)

Sasaki, Syota; Yamada, Tadashi; Yamada, Tomohito J.

2014-05-01

We aim to propose a kinematic-based methodology similar with runoff analysis for readily understandable radiological protection. A merit of this methodology is to produce sufficiently accurate effective doses by basic analysis. The great earthquake attacked the north-east area in Japan on March 11, 2011. The system of electrical facilities to control Fukushima Daiichi nuclear power plant was completely destroyed by the following tsunamis. From the damaged reactor containment vessels, an amount of radioactive isotopes had leaked and been diffused in the vicinity of the plant. Radiological internal exposure caused by ingestion of food containing radioactive isotopes has become an issue of great interest to the public, and has caused excessive anxiety because of a deficiency of fundamental knowledge concerning radioactivity. Concentrations of radioactivity in the human body and internal exposure have been studied extensively. Previous radiologic studies, for example, studies by International Commission on Radiological Protection(ICRP), employ a large-scale computational simulation including actual mechanism of metabolism in the human body. While computational simulation is a standard method for calculating exposure doses among radiology specialists, these methods, although exact, are too difficult for non-specialists to grasp the whole image owing to the sophistication. In this study, the human body is treated as a vessel. The number of radioactive atoms in the human body can be described by an equation of continuity, which is the only governing equation. Half-life, the period of time required for the amount of a substance decreases by half, is only parameter to calculate the number of radioactive isotopes in the human body. Half-life depends only on the kinds of nuclides, there are no arbitrary parameters. It is known that the number of radioactive isotopes decrease exponentially by radioactive decay (physical outflow). It is also known that radioactive isotopes

Radiogenic Isotopes As Paleoceanographic Tracers in Deep-Sea Corals: Advances in TIMS Measurements of Pb Isotopes and Application to Southern Ocean Corals

Science.gov (United States)

Wilson, D. J.; van de Flierdt, T.; Bridgestock, L. J.; Paul, M.; Rehkamper, M.; Robinson, L. F.; Adkins, J. F.

2014-12-01

Deep-sea corals have emerged as a valuable archive of deep ocean paleoceanographic change, with uranium-series dating providing absolute ages and the potential for centennial resolution. In combination with measurements of radiocarbon, neodymium isotopes and clumped isotopes, this archive has recently been exploited to reconstruct changes in ventilation, water mass sourcing and temperature in relation to millennial climate change. Lead (Pb) isotopes in both corals and seawater have also been used to track anthropogenic inputs through space and time and to trace transport pathways within the oceans. Better understanding of the oceanic Pb cycle is emerging from the GEOTRACES programme. However, while Pb isotopes have been widely used in environmental studies, their full potential as a (pre-anthropogenic) paleoceanographic tracer remains to be exploited. In deep-sea corals, challenges exist from low Pb concentrations in aragonite in comparison to secondary coatings, the potential for contamination, and the efficient elemental separation required for measurement by thermal ionisation mass spectrometry (TIMS). Here we discuss progress in measuring Pb isotopes in coral aragonite using a 207Pb-204Pb double spike on a ThermoFinnigan Triton TIMS. For a 2 ng NIST-981 Pb standard, the long term reproducibility (using 1011 Ω resistors) is ~1000 ppm (2 s.d.) on 206Pb/204Pb, 207Pb/204Pb and 208Pb/204Pb ratios. We now show that using a new 1012 Ω resistor to measure the small 204Pb beam improves the internal precision on these ratios from ~500 ppm (2 s.e.) to ~250 ppm (2 s.e.) and we envisage a potential improvement in the long term reproducibility as a consequence. We further assess the internal precision and external reproducibility of our method using a BCR-2 rock standard and an in-house coral standard. Preliminary evidence on the application of this method to natural samples is derived from cleaning experiments and replication tests on deep-sea corals from the Southern

Data standards for the international virtual observatory

Directory of Open Access Journals (Sweden)

R J Hanisch

2006-11-01

Full Text Available A primary goal of the International Virtual Observatory Alliance, which brings together Virtual Observatory Projects from 16 national and international development projects, is to develop, evaluate, test, and agree upon standards for astronomical data formatting, data discovery, and data delivery. In the three years that the IVOA has been in existence, substantial progress has been made on standards for tabular data, imaging data, spectroscopic data, and large-scale databases and on managing the metadata that describe data collections and data access services. In this paper, I describe how the IVOA operates and give my views as to why such a broadly based international collaboration has been able to make such rapid progress.

A double isotope dilution method for assaying of polycyclic aromatic hydrocarbons in cigarette smoke condensate

International Nuclear Information System (INIS)

Bechtold, W.E.; Chen, B.T.

1988-01-01

This report describes a double isotope dilution method for analysis of the polycyclic aromatic hydrocarbons (PAH) phenanthrene, fluor-anthene, pyrene, and benzo[a]pyrene in cigarette smoke particulates. The first isotope dilution used deuterated analogues of the first three PAH as internal standards. The second isotope dilution, for benzo[a]pyrene, used the tritiated analogue as an internal standard. The PAH were isolated from extracts of cigarette smoke particulates using a two-step procedure based on selective extraction from aqueous dimethyl sulfoxide (DMSO) followed by chromatography on silica gel extraction columns. After isolation, aliquots of the samples were analyzed for phenanthrene, pyrene, and fluoranthene by gas chromatography with mass spectrometric detection (GC/MS). Separate aliquots of the samples were analyzed for benzo[a]pyrene by high pressure liquid chromatography with fluorescence detection followed by liquid scintillation spectrometry. PAH levels from cigarette smoke condensates collected from different exposure modes were compared; no exposure-related differences were found. (author)

International physical protection standards: support for development and implementation

International Nuclear Information System (INIS)

Soo Hoo, M.S.

2002-01-01

Full text: Since 1972, the IAEA has been a recognized organization in promoting the development of international standards on the physical protection of nuclear materials. This responsibility has continued through the present in the 1999 publication of the fourth revision of INFCIRC/225, the physical protection of nuclear material and nuclear facilities and in being the repository for the convention on the physical protection of nuclear material which was originally published in 1980 as INFCIRC/274. The IAEA has also published other reference documents in support these two standards. With changing world events and greater concern for the physical protection of nuclear materials and facilities, IAEA member states have increased IAEA physical protection responsibilities. Currently, the IAEA is serving as the secretariat for drafting revisions to the physical protection convention. The proposed revisions will strengthen international physical protection standards through the incorporation of physical protection fundamentals that should apply to all nuclear materials in international or domestic use, storage and transport. Furthermore, the physical protection fundamentals would also extend to include nuclear facilities. Presently, the physical protection convention applies only to nuclear materials that are in international transport. To complement efforts to develop and promote international physical protection standards, the IAEA is actively involved in assisting member states with the implementation of the standards. This is accomplished through the delivery of training courses, workshops and hosting other international forums for the exchange of information. Through review services such as the international physical protection advisory service (IPPAS), the IAEA provides advice to member states on the application of international standards at national and facility-specific levels. These services can be followed up with technical support to implement the

Internal standardization in atomic-emission spectrometry using inductively coupled plasma

International Nuclear Information System (INIS)

Moore, G.L.

1985-01-01

The principle of internal standardization has been used in quantitative analytical emission spectroscopy since 1925 to minimize the errors arising from fluctuations in sample preparation, excitation-source conditions, and detection parameters. Although modern spectroscopic excitation sources are far more stable and electronic detection methods are more precise than before, the system for the introduction of the sample in spectrometric analysis using inductively coupled plasma (ICP) introduces significant errors, and internal standardization can still play a useful role in improving the overall precision of the analytical results. The criteria for the selection of the elements to be used as internal standards in arc and spark spectrographic analysis apply to a much lesser extent in ICP-spectrometric analysis. Internal standardization is recommended for use in routine ICP-simultaneous spectrometric analysis to improve its accuracy and precision and to provide a monitor for the reassurance of the analyst. However, the selection of an unsuitable reference element can result in misuse of the principle of internal standardization and, although internal standardization can be applied when a sequential monochromator is used, the main sources of error will not be minimized

Standard test method for isotopic analysis of hydrolyzed uranium hexafluoride and uranyl nitrate solutions by thermal ionization mass spectrometry

CERN Document Server

American Society for Testing and Materials. Philadelphia

2005-01-01

1.1 This method applies to the determination of isotopic composition in hydrolyzed nuclear grade uranium hexafluoride. It covers isotopic abundance of 235U between 0.1 and 5.0 % mass fraction, abundance of 234U between 0.0055 and 0.05 % mass fraction, and abundance of 236U between 0.0003 and 0.5 % mass fraction. This test method may be applicable to other isotopic abundance providing that corresponding standards are available. 1.2 This test method can apply to uranyl nitrate solutions. This can be achieved either by transforming the uranyl nitrate solution to a uranyl fluoride solution prior to the deposition on the filaments or directly by depositing the uranyl nitrate solution on the filaments. In the latter case, a calibration with uranyl nitrate standards must be performed. 1.3 This test method can also apply to other nuclear grade matrices (for example, uranium oxides) by providing a chemical transformation to uranyl fluoride or uranyl nitrate solution. 1.4 This standard does not purport to address al...

78 FR 18321 - International Code Council: The Update Process for the International Codes and Standards

Science.gov (United States)

2013-03-26

... Energy Conservation Code. International Existing Building Code. International Fire Code. International... Code. International Property Maintenance Code. International Residential Code. International Swimming Pool and Spa Code International Wildland-Urban Interface Code. International Zoning Code. ICC Standards...

Globalization quickly increased need for moving from local to international standards

Energy Technology Data Exchange (ETDEWEB)

Cappelli, Cataldo

2005-07-01

'Standardization' quickly changed in the past few years, due to the market's globalization that needs international standards as important instruments in eliminating technical barriers to trade. The 'Petroleum Sector' chose moving to international standards jointly processed by the International Organization for Standardization (ISO) and the American Petroleum Institute (API) that played the role of historical reference. Taking into account that oil industry wants only one Standard worldwide used, also Europe decided for adopting these ISO Standards as European Standards. The result is much better considering that also Russia and China seem to adopt these ISO documents as their national standards. It is so becoming much more significant the 'motto' that ISO TC 67 'Materials, equipment and offshore structures for petroleum, petrochemical and natural gas industries' adopted for its standardization activities: 'Do it once, do it right, do it internationally'. Examples of such international Standards worldwide used as National Standards are: ISO 11960:2004 - 'Steel pipes for use as casing or tubing for wells' and; ISO/DIS 3183 - 'Steel pipe for pipeline transportation systems' (under preparation). Standardization has so grown from technical to management tool and countries are also moving, including standards in more areas of its legislations. (author)

International Financial Reporting Standards and differential reporting

OpenAIRE

Jarvis, Robin; Collis, Jill

2003-01-01

This paper examines the international development of financial reporting standards for smaller entities from a UK perspective. It examines the three elements of differential reporting: abbreviated accounts, the Financial Reporting Standard for Smaller Entities and exemption from the statutory audit.

International Standards for Neurological Classification of Spinal Cord Injury:

DEFF Research Database (Denmark)

Kirshblum, S C; Biering-Sørensen, Fin; Betz, R

2014-01-01

The International Standards for the Neurological Classification of Spinal Cord Injury (ISNCSCI) is routinely used to determine levels of injury and to classify the severity of the injury. Questions are often posed to the International Standards Committee of the American Spinal Injury Association...

Using PISA as an International Benchmark in Standard Setting.

Science.gov (United States)

Phillips, Gary W; Jiang, Tao

2015-01-01

This study describes how the Programme for International Student Assessment (PISA) can be used to internationally benchmark state performance standards. The process is accomplished in three steps. First, PISA items are embedded in the administration of the state assessment and calibrated on the state scale. Second, the international item calibrations are then used to link the state scale to the PISA scale through common item linking. Third, the statistical linking results are used as part of the state standard setting process to help standard setting panelists determine how high their state standards need to be in order to be internationally competitive. This process was carried out in Delaware, Hawaii, and Oregon, in three subjects-science, mathematics and reading with initial results reported by Phillips and Jiang (2011). An in depth discussion of methods and results are reported in this article for one subject (mathematics) and one state (Hawaii).

Standard test method for radiochemical determination of uranium isotopes in soil by alpha spectrometry

CERN Document Server

American Society for Testing and Materials. Philadelphia

2011-01-01

1.1 This test method covers the determination of alpha-emitting uranium isotopes in soil. This test method describes one acceptable approach to the determination of uranium isotopes in soil. 1.2 The test method is designed to analyze 10 g of soil; however, the sample size may be varied to 50 g depending on the activity level. This test method may not be able to completely dissolve all forms of uranium in the soil matrix. Studies have indicated that the use of hydrofluoric acid to dissolve soil has resulted in lower values than results using total dissolution by fusion. 1.3 The lower limit of detection is dependent on count time, sample size, detector, background, and tracer yield. The chemical yield averaged 78 % in a single laboratory evaluation, and 66 % in an interlaboratory collaborative study. 1.4 The values stated in SI units are to be regarded as standard. The values given in parentheses are for information only. 1.5 This standard does not purport to address all of the safety concerns, if any, ass...

International conference on isotopic and nuclear analytical techniques for health and environment. Book of abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

2003-07-01

Decision makers and stakeholders are becoming increasingly dependent on reliable chemical measurements that serve as a basis for decisions related to health, consumer safety, commerce, environment protection and compliance to regulations. Several millions of analytical results are produced annually, thus consuming appreciable amounts of resources. Reliability of these data is of major concern if cost-benefit figures are applied. Nuclear and isotopic analytical techniques (NATs) have been supported by the IAEA as part of their mandate to foster the peaceful use of nuclear energy for many years. Nuclear analytical laboratories have been installed and upgraded through Technical Co-operation assistance in many Member State laboratories. These techniques, including INAA, XRF, PIXE, stable and radioisotopes, spectrometroscopy, etc. have been applied to a wide range of subjects with varying success. Nuclear analytical techniques, featuring some intrinsic quality control aspects, such as multi-nuclide analysis, frequently serve as 'reference methods' to cross-check critical results. As nuclear properties of elements are targeted, matrix problems seem to be negligible to a great extent. The International Conference on Isotopic and Nuclear Analytical Techniques for Health and Environment was held 10-13 June 2003 in Vienna, Austria. The main purpose of this Conference was to bring together scientists, technologists, representatives of industry and regulatory authorities to exchange information and review the status of current developments and applications of isotopic and nuclear analytical techniques, and to discuss future trends and developments. A further objective is to identify potential opportunities for developing countries for applying isotopic and nuclear analytical techniques in health and environmental studies, and to consider the promotion and transfer of such technology. International developments and trends in health care, nutrition, and environmental monitoring

Normalization Methods and Selection Strategies for Reference Materials in Stable Isotope Analyses - Review

International Nuclear Information System (INIS)

Skrzypek, G.; Sadler, R.; Paul, D.; Forizs, I.

2011-01-01

A stable isotope analyst has to make a number of important decisions regarding how to best determine the 'true' stable isotope composition of analysed samples in reference to an international scale. It has to be decided which reference materials should be used, the number of reference materials and how many repetitions of each standard is most appropriate for a desired level of precision, and what normalization procedure should be selected. In this paper we summarise what is known about propagation of uncertainties associated with normalization procedures and propagation of uncertainties associated with reference materials used as anchors for the determination of 'true' values for δ''1''3C and δ''1''8O. Normalization methods Several normalization methods transforming the 'raw' value obtained from mass spectrometers to one of the internationally recognized scales has been developed. However, as summarised by Paul et al. different normalization transforms alone may lead to inconsistencies between laboratories. The most common normalization procedures are: single-point anchoring (versus working gas and certified reference standard), modified single-point normalization, linear shift between the measured and the true isotopic composition of two certified reference standards, two-point and multipoint linear normalization methods. The accuracy of these various normalization methods has been compared by using analytical laboratory data by Paul et al., with the single-point and normalization versus tank calibrations resulting in the largest normalization errors, and that also exceed the analytical uncertainty recommended for δ 13 C. The normalization error depends greatly on the relative differences between the stable isotope composition of the reference material and the sample. On the other hand, the normalization methods using two or more certified reference standards produces a smaller normalization error, if the reference materials are bracketing the whole range of

Minimum quality standards and international trade

DEFF Research Database (Denmark)

Baltzer, Kenneth Thomas

2011-01-01

This paper investigates the impact of a non-discriminating minimum quality standard (MQS) on trade and welfare when the market is characterized by imperfect competition and asymmetric information. A simple partial equilibrium model of an international Cournot duopoly is presented in which a domes...... prefer different levels of regulation. As a result, international trade disputes are likely to arise even when regulation is non-discriminating....

Globalization quickly increased need for moving from local to international standards

Energy Technology Data Exchange (ETDEWEB)

Cappelli, Cataldo

2005-07-01

'Standardization' quickly changed in the past few years, due to the market's globalization that needs international standards as important instruments in eliminating technical barriers to trade. The 'Petroleum Sector' chose moving to international standards jointly processed by the International Organization for Standardization (ISO) and the American Petroleum Institute (API) that played the role of historical reference. Taking into account that oil industry wants only one Standard worldwide used, also Europe decided for adopting these ISO Standards as European Standards. The result is much better considering that also Russia and China seem to adopt these ISO documents as their national standards. It is so becoming much more significant the 'motto' that ISO TC 67 'Materials, equipment and offshore structures for petroleum, petrochemical and natural gas industries' adopted for its standardization activities: 'Do it once, do it right, do it internationally'. Examples of such international Standards worldwide used as National Standards are: ISO 11960:2004 - 'Steel pipes for use as casing or tubing for wells' and; ISO/DIS 3183 - 'Steel pipe for pipeline transportation systems' (under preparation). Standardization has so grown from technical to management tool and countries are also moving, including standards in more areas of its legislations. (author)

Report of International Workshop on tracing isotopic composition of past and present precipitation - opportunities for climate and water studies

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

The Workshop on Tracing Isotopic Composition of Past and Present Precipitation - Opportunities for Climate and Water Studies, was jointly organized by the World Meteorological Organization (WMO), the International Atomic Energy Agency (IAEA), Past Global Changes (PAGES) - a core project of the International Geosphere - Biosphere Programme (IGBP), and the International Association of Hydrological Sciences (IAHS). The Global Network ``Isotopes in Precipitation`` (GNIP) was initiated by IAEA in 1958 and became operational in 1961. The main objective was to collect systematic data on isotopic content of precipitation on a global scale and to establish temporal and spatial variations of environmental isotopes in precipitation. The network is now expected to serve additional purposes, namely as a benchmark for the interpretation of paleo-records, as a validation tool for Global Circulation Models, and for establishing large-scale regional (and continental-scale) waster balances. Furthermore, the structure of GNIP should be strengthened. This includes the build-up of: stations located close to major natural climatic archives (e.g. Greenland, mountain areas); stations which represent climatically sensitive areas (indicated by GCM`s and biome models). Isotope monitoring of river outflow from major continental basins should be initiated. This could be realized in co-operation with the UNEP/WHO Global Environmental Monitoring System-Water (GEMS-Water). The deuterium excess parameter ({delta}) is of particular importance in climate modelling and in the understanding of hydro-meteorological pathways. The use of the deuterium excess imposes strict requirements on the accuracy of deuterium and oxygen-18 analysis. A GNIP-based worldwide documentation of quality control regarding sampling, shipping and measurements is needed. The IAEA/WMO database and other isotope data sets should be included in the World Data Center A for palaeo-climatology. Refs, figs, tabs.

Report of International Workshop on tracing isotopic composition of past and present precipitation - opportunities for climate and water studies

International Nuclear Information System (INIS)

1995-01-01

The Workshop on Tracing Isotopic Composition of Past and Present Precipitation - Opportunities for Climate and Water Studies, was jointly organized by the World Meteorological Organization (WMO), the International Atomic Energy Agency (IAEA), Past Global Changes (PAGES) - a core project of the International Geosphere - Biosphere Programme (IGBP), and the International Association of Hydrological Sciences (IAHS). The Global Network ''Isotopes in Precipitation'' (GNIP) was initiated by IAEA in 1958 and became operational in 1961. The main objective was to collect systematic data on isotopic content of precipitation on a global scale and to establish temporal and spatial variations of environmental isotopes in precipitation. The network is now expected to serve additional purposes, namely as a benchmark for the interpretation of paleo-records, as a validation tool for Global Circulation Models, and for establishing large-scale regional (and continental-scale) waster balances. Furthermore, the structure of GNIP should be strengthened. This includes the build-up of: stations located close to major natural climatic archives (e.g. Greenland, mountain areas); stations which represent climatically sensitive areas (indicated by GCM's and biome models). Isotope monitoring of river outflow from major continental basins should be initiated. This could be realized in co-operation with the UNEP/WHO Global Environmental Monitoring System-Water (GEMS-Water). The deuterium excess parameter (δ) is of particular importance in climate modelling and in the understanding of hydro-meteorological pathways. The use of the deuterium excess imposes strict requirements on the accuracy of deuterium and oxygen-18 analysis. A GNIP-based worldwide documentation of quality control regarding sampling, shipping and measurements is needed. The IAEA/WMO database and other isotope data sets should be included in the World Data Center A for palaeo-climatology. Refs, figs, tabs

Isotopes Project

International Nuclear Information System (INIS)

Dairiki, J.M.; Browne, E.; Firestone, R.B.; Lederer, C.M.; Shirley, V.S.

1984-01-01

The Isotopes Project compiles and evaluates nuclear structure and decay data and disseminates these data to the scientific community. From 1940-1978 the Project had as its main objective the production of the Table of Isotopes. Since publication of the seventh (and last) edition in 1978, the group now coordinates its nuclear data evaluation efforts with those of other data centers via national and international nuclear data networks. The group is currently responsible for the evaluation of mass chains A = 167-194. All evaluated data are entered into the International Evaluated Nuclear Structure Data File (ENSDF) and are published in Nuclear Data Sheets. In addition to the evaluation effort, the Isotopes Project is responsible for production of the Radioactivity Handbook

International Standardization of Library and Documentation Techniques.

Science.gov (United States)

International Federation for Documentation, The Hague (Netherlands).

This comparative study of the national and international standards, rules and regulations on library and documentation techniques adopted in various countries was conducted as a preliminary step in determining the minimal bases for facilitating national and international cooperation between documentalists and librarians. The study compares and…

Adoption of International Financial Accounting Reporting Standards ...

African Journals Online (AJOL)

This study examines the International Financial Accounting Reporting Standards adoption practices around the world and the way these practices are reflected in the financial statements of companies in different countries. It also examines the incentives/ motivations for the variations in the type of International Financial ...

Experience with nuclear safety standards development in non-governmental international organizations

International Nuclear Information System (INIS)

Becker, K.

1985-01-01

Besides the IAEA as a 'governmental' organization dealing with basic safety recommendations addressed primarily to the national regulatory bodies in developing countries, two closely related non-governmental international standards organizations have gained extensive experience in the field of nuclear standardization. Over more than 25 years since their formation, both (a) the International Organization for Standardization's (ISO) Technical Committee 85 'Nuclear Energy', in particular in its Sub-Committee 3 'Reactor Technology and Safety' and (b) the International Electrotechnical Commission's (IEC) Technical Committee 45 'Nuclear Instrumentation' have published numerous standards. A brief review is given of these, draft standards, and other documents planned to become international standards. Many of them deal with rather specialized topics typical for 'industrial' standards such as standardized procedures, instruments, methods, materials, test methods, terminology, and signs and symbols, but others are directly related to more basic safety issues. In some areas such as quality assurance, seismic aspects of siting and terminology, there has been in the past occasional overlap in the activities of the NUSS programme, IEC and ISO. Letters of Understanding have since 1981 contributed to clarifying the borderlines and to avoiding redundant efforts. Also, some experiences and problems are described arising, for example, from the harmonization of different national safety philosophies and traditions into universally accepted international standards, and the transfer of international standards into national standards systems. Finally, based on a recent comprehensive compilation of some 3300 nuclear standards and standards projects, an attempt is made to present a cost/benefit analysis and an outlook on future developments. (author)

Trade and the distributional politics of international labour standards

OpenAIRE

Oslington, Paul

2005-01-01

This paper constructs a simple general equilibrium model of the trade and distributional effects of spreading advanced country international labour standards to developing countries. Labour standards (including minimum safety requirements, prohibition of prison and child labour, and rights to unionise) are represented as a floor to the cost of employing labour. The model shows how the spread of standards affects the terms of trade and pattern of international specialisation, and can shift ...

European and International Standards on health and safety in welding

International Nuclear Information System (INIS)

Howe, A

2009-01-01

A number of European and International Standards on health and safety in welding have been published in recent years and work on several more is nearing completion. These standards have been prepared jointly by the International Standards Organization (ISO) and the European Committee for Standardization (CEN). The standards development work has mostly been led by CEN/TC 121/SC 9, with excellent technical input from experts within Europe; but work on the revision of published standards, which has recently gathered pace, is now being carried out by ISO/TC 44/SC 9, with greater international involvement. This paper gives an overview of the various standards that have been published, are being revised or are under development in this field of health and safety in welding, seeking to (i) increase international awareness of published standards, (ii) encourage wider participation in health and safety in welding standards work and (iii) obtain feedback and solicit comments on standards that are currently under development or revision. Such an initiative is particularly timely because work is currently in progress on the revision of one of the more important standards in this field, namely EN ISO 10882:2001 Health and safety in welding and allied processes- Sampling of airborne particles and gases in the operator's breathing zone - Part 1: Sampling of airborne particles.

International Symposium on Isotopes in Hydrology, Marine Ecosystems, and Climate Change Studies. Presentations

International Nuclear Information System (INIS)

2011-01-01

Human activities have had a far-reaching impact on the aquatic environments - both marine and freshwater systems. The protection of these systems against further deterioration and the promotion of sustainable use are vital. In order to deepen understanding about the main processes affecting the present situation, as well as possible developments in the future, further investigation is required. The oceans play a major role in climate change, for example, and ocean acidification by increased CO2 release is one major threat to the world's oceans. Isotope methods can play a critical role in identifying and quantifying key processes within aquatic environments. Addressing the problems of global water resources has become a matter of urgency. Water resources are subject to multiple pressures for various reasons, including increasing populations, climate change, rising food and energy costs, the global economic crisis and pollutant loading. Isotope hydrology provides the unique and critical tools required to address complex water problems and helps managers and policy makers understand the closely intertwined relationship between water resources and the various pressures affecting them, as well as the issue of sustainability. The symposium will be an important forum for the exchange of knowledge on the present state of marine and freshwater environments, use of isotopes in water resources investigations and management, and climate change studies. The meeting will involve leading scientists in the field of climate change and hydrology, as well as representatives from other United Nations bodies and international organizations that focus on climate change and other important environmental issues. TOPICS: The role of isotopes in understanding and modelling climate change, marine ecosystems and the water cycle; Carbon dioxide sequestration and related aspects of the carbon cycle, such as ocean acidification; Isotopes in groundwater flow modelling for large aquifers

Studying of isotope structure of uranium by alpha-spectrometric method

International Nuclear Information System (INIS)

Sattarov, G.S.; Muzafarov, A.M.; Petukhov, O.F.; Petrenko, V.Z.

2004-01-01

Full text: The knowledge of isotope structure of uranium in waters, in minerals and in finished goods gives the helpful information on the radiation and nuclear-physical processes occurring in natural environments. Besides, customers put a question before uranium producing enterprises on the control of limiting concentration of an isotope 234 U in finished goods (uranium protoxide-oxide). For these reasons studying and development of techniques of definition of isotope structure of uranium is an actual task. In this connection for researches alpha - spectrometers 'PROGRESS-ALPHA' produced by R and D 'DOZE' Russia and firms 'Canberra' the USA were used. The isotope structure of uranium ( 234 U, 235 U, 238 U) was determined on a known ratio 234 U/ 238 U, which is equal to 53,41micrograms/gram. Identification of isotopes carried out by 4198 keV ( 235 U), 4395 keV ( 234 U) and 4773 keV ( 238 U). The technique of radiochemical preparation of samples to the analysis included: clearing of organic chemistry and preventing natural isotopes; drawing by a method electrolytic sedimentation on a metal substrate (d=24mm) an active stain, the area 4,5 cm 2 , with isotropy distribution of ions 234 U, 235 U, 238 U. As standards, the international and All-Russian standards with known contents 234 U were used. The isotope structure of uranium in uranium protoxide-oxide, chemical concentrates, technological solutions is determined. Infringements of isotope balance 234 U/ 238 U on separate sites of fulfilled uranium deposits and in technological products are found out

Best-Matched Internal Standard Normalization in Liquid Chromatography-Mass Spectrometry Metabolomics Applied to Environmental Samples.

Science.gov (United States)

Boysen, Angela K; Heal, Katherine R; Carlson, Laura T; Ingalls, Anitra E

2018-01-16

The goal of metabolomics is to measure the entire range of small organic molecules in biological samples. In liquid chromatography-mass spectrometry-based metabolomics, formidable analytical challenges remain in removing the nonbiological factors that affect chromatographic peak areas. These factors include sample matrix-induced ion suppression, chromatographic quality, and analytical drift. The combination of these factors is referred to as obscuring variation. Some metabolomics samples can exhibit intense obscuring variation due to matrix-induced ion suppression, rendering large amounts of data unreliable and difficult to interpret. Existing normalization techniques have limited applicability to these sample types. Here we present a data normalization method to minimize the effects of obscuring variation. We normalize peak areas using a batch-specific normalization process, which matches measured metabolites with isotope-labeled internal standards that behave similarly during the analysis. This method, called best-matched internal standard (B-MIS) normalization, can be applied to targeted or untargeted metabolomics data sets and yields relative concentrations. We evaluate and demonstrate the utility of B-MIS normalization using marine environmental samples and laboratory grown cultures of phytoplankton. In untargeted analyses, B-MIS normalization allowed for inclusion of mass features in downstream analyses that would have been considered unreliable without normalization due to obscuring variation. B-MIS normalization for targeted or untargeted metabolomics is freely available at https://github.com/IngallsLabUW/B-MIS-normalization .

International collaborative study for the calibration of proposed International Standards for thromboplastin, rabbit, plain and for thromboplastin, recombinant, human, plain

DEFF Research Database (Denmark)

van den Besselaar, A M H P; Chantarangkul, V; Angeloni, F

2018-01-01

BACKGROUND: The availability of International Standards for thromboplastin is essential for the calibration of routine reagents and hence the calculation of the International Normalized Ratio (INR). Stocks of the current 4(th) International Standards are running low. Candidate replacement materia......) international standard (rTF/09). The candidate materials have been accepted by WHO as the 5(th) International Standards for thromboplastin, rabbit plain, and thromboplastin, recombinant, human, plain. This article is protected by copyright. All rights reserved.......BACKGROUND: The availability of International Standards for thromboplastin is essential for the calibration of routine reagents and hence the calculation of the International Normalized Ratio (INR). Stocks of the current 4(th) International Standards are running low. Candidate replacement materials...... have been prepared. This report describes the calibration of the proposed 5(th) International Standards for thromboplastin, rabbit, plain (coded RBT/16) and for thromboplastin, recombinant, human, plain (coded rTF/16). METHODS: An international collaborative study was carried out for the assignment...

Advancements in internationally accepted standards for radiation processing

International Nuclear Information System (INIS)

Farrar, H. IV; Derr, D.D.; Vehar, D.W.

1993-01-01

Subcommittees of the American Society for Testing and Materials (ASTM) are developing standards on various aspects of radiation processing. Nine standards on how to select and calibrate dosimeters, where to put them, how many to use, and how to use individual types of dosimeter systems have been published. The group is also developing standards on how to use gamma, electron beam, and X-ray facilities for radiation processing, and a standard on how to treat dose uncertainties. Efforts are underway to promote inclusion of these standards into procedures now being developed by government agencies and by international groups such as the United Nations' International Consultative Group on Food Irradiation (ICGFI) in order to harmonize regulations and help avoid trade barriers. Standards on good irradiation practices for meat and poultry and for fresh fruits, and for the irradiation of seafood and spices have been developed. These food-related standards are based on practices previously published by ICGFI. Standards for determining doses for radiation hardness testing of electronics have been developed. Standards on the Fricke and TLD dosimetry systems are equally useful in other radiation processing applications. (Author)

Brief International Cognitive Assessment for MS (BICAMS): international standards for validation.

Science.gov (United States)

Benedict, Ralph H B; Amato, Maria Pia; Boringa, Jan; Brochet, Bruno; Foley, Fred; Fredrikson, Stan; Hamalainen, Paivi; Hartung, Hans; Krupp, Lauren; Penner, Iris; Reder, Anthony T; Langdon, Dawn

2012-07-16

An international expert consensus committee recently recommended a brief battery of tests for cognitive evaluation in multiple sclerosis. The Brief International Cognitive Assessment for MS (BICAMS) battery includes tests of mental processing speed and memory. Recognizing that resources for validation will vary internationally, the committee identified validation priorities, to facilitate international acceptance of BICAMS. Practical matters pertaining to implementation across different languages and countries were discussed. Five steps to achieve optimal psychometric validation were proposed. In Step 1, test stimuli should be standardized for the target culture or language under consideration. In Step 2, examiner instructions must be standardized and translated, including all information from manuals necessary for administration and interpretation. In Step 3, samples of at least 65 healthy persons should be studied for normalization, matched to patients on demographics such as age, gender and education. The objective of Step 4 is test-retest reliability, which can be investigated in a small sample of MS and/or healthy volunteers over 1-3 weeks. Finally, in Step 5, criterion validity should be established by comparing MS and healthy controls. At this time, preliminary studies are underway in a number of countries as we move forward with this international assessment tool for cognition in MS.

Standards: The Keys to Domestic and International Competitiveness.

Science.gov (United States)

Hunter, Robert D.

1993-01-01

Demonstrates the importance of standards for the competitiveness of U.S. companies and for international trade. The value of standards in research and development, marketing, design, purchasing, manufacturing, installation, and service is explained. Examples of specific standards and their application to the computer industry are included. (10…

International implications of nuclear Q.A. standards

International Nuclear Information System (INIS)

Stoddart, D.E.

1976-01-01

The work of the International Atomic Energy Agency (I.A.E.A.) in the field of Quality Assurance is aimed at preparing a Code of Practice covering recommendations on safety aspects only which is designed to be usable by all nations. This Code is followed up by a series of Safety Guides as aids to developing nations faced with the need to regulate and assure safety, reliability and quality. The I.A.E.A. Code is not written as a mandatory document and it can only recommend and therefore the term 'should' is used throughout. The International Organization for Standardization (I.S.O.) is concerned with producing standards and as such the proposed I.S.O. draft standard on 'Quality Assurance for Nuclear Power Plants' is written in mandatory language, it uses the word 'shall'. The I.S.O. standard will also cover not only safety aspects but also those of a successfully operating nuclear power plant. The I.S.O. Working Group is charged with producing standards on quality assurance covering the design, procurement, fabrication, construction, operation, maintenance and decommissioning of structure, systems and components of nuclear power plants. The work of both organizations is discussed briefly. (author)

Hot vacuum extraction-isotopic dilution mass spectrometry for determination of hydrogen isotopes in zircaloys

International Nuclear Information System (INIS)

Shi, Y.; Leeson, P.K.; Wilkin, D.; Britton, A.; Macleod, R.

2016-01-01

A hot vacuum extraction-isotope dilution mass spectrometry (HVE-IDMS) was studied for determination of hydrogen isotopes in zirconium metal and alloys as nuclear reactor materials. A theoretical assessment of the completeness of the extraction of hydrogen isotopes under the chosen condition was carried out based on the hydrogen and deuterium solubility data for zirconium. The optimal isotopic spiking condition for conventional IDMS was further explored for the special case IDMS where the isotope abundance of the samples is varied and non-natural. Applying the optimal conditions, the accurate IDMS determination was realized. The agreement between the measured values and the certified or prepared values of standard reference materials and homemade standard materials validate the method developed. (author)

Isotope pattern deconvolution as a tool to study iron metabolism in plants.

Science.gov (United States)

Rodríguez-Castrillón, José Angel; Moldovan, Mariella; García Alonso, J Ignacio; Lucena, Juan José; García-Tomé, Maria Luisa; Hernández-Apaolaza, Lourdes

2008-01-01

Isotope pattern deconvolution is a mathematical technique for isolating distinct isotope signatures from mixtures of natural abundance and enriched tracers. In iron metabolism studies measurement of all four isotopes of the element by high-resolution multicollector or collision cell ICP-MS allows the determination of the tracer/tracee ratio with simultaneous internal mass bias correction and lower uncertainties. This technique was applied here for the first time to study iron uptake by cucumber plants using 57Fe-enriched iron chelates of the o,o and o,p isomers of ethylenediaminedi(o-hydroxyphenylacetic) acid (EDDHA) and ethylenediamine tetraacetic acid (EDTA). Samples of root, stem, leaves, and xylem sap, after exposure of the cucumber plants to the mentioned 57Fe chelates, were collected, dried, and digested using nitric acid. The isotopic composition of iron in the samples was measured by ICP-MS using a high-resolution multicollector instrument. Mass bias correction was computed using both a natural abundance iron standard and by internal correction using isotope pattern deconvolution. It was observed that, for plants with low 57Fe enrichment, isotope pattern deconvolution provided lower tracer/tracee ratio uncertainties than the traditional method applying external mass bias correction. The total amount of the element in the plants was determined by isotope dilution analysis, using a collision cell quadrupole ICP-MS instrument, after addition of 57Fe or natural abundance Fe in a known amount which depended on the isotopic composition of the sample.

Isotope pattern deconvolution as a tool to study iron metabolism in plants

Energy Technology Data Exchange (ETDEWEB)

Rodriguez-Castrillon, Jose A.; Moldovan, Mariella; Garcia Alonso, J.I. [University of Oviedo, Department of Physical and Analytical Chemistry, Oviedo (Spain); Lucena, Juan J.; Garcia-Tome, Maria L.; Hernandez-Apaolaza, Lourdes [Autonoma University of Madrid, Department of Agricultural Chemistry, Madrid (Spain)

2008-01-15

Isotope pattern deconvolution is a mathematical technique for isolating distinct isotope signatures from mixtures of natural abundance and enriched tracers. In iron metabolism studies measurement of all four isotopes of the element by high-resolution multicollector or collision cell ICP-MS allows the determination of the tracer/tracee ratio with simultaneous internal mass bias correction and lower uncertainties. This technique was applied here for the first time to study iron uptake by cucumber plants using {sup 57}Fe-enriched iron chelates of the o,o and o,p isomers of ethylenediaminedi(o-hydroxyphenylacetic) acid (EDDHA) and ethylenediamine tetraacetic acid (EDTA). Samples of root, stem, leaves, and xylem sap, after exposure of the cucumber plants to the mentioned {sup 57}Fe chelates, were collected, dried, and digested using nitric acid. The isotopic composition of iron in the samples was measured by ICP-MS using a high-resolution multicollector instrument. Mass bias correction was computed using both a natural abundance iron standard and by internal correction using isotope pattern deconvolution. It was observed that, for plants with low {sup 57}Fe enrichment, isotope pattern deconvolution provided lower tracer/tracee ratio uncertainties than the traditional method applying external mass bias correction. The total amount of the element in the plants was determined by isotope dilution analysis, using a collision cell quadrupole ICP-MS instrument, after addition of {sup 57}Fe or natural abundance Fe in a known amount which depended on the isotopic composition of the sample. (orig.)

Optimising the Number of Replicate- Versus Standard Measurements for Carbonate Clumped Isotope Thermometry

Science.gov (United States)

Kocken, I.; Ziegler, M.

2017-12-01

Clumped isotope measurements on carbonates are a quickly developing and promising palaeothermometry proxy1-3. Developments in the field have brought down the necessary sample amount and improved the precision and accuracy of the measurements. The developments have included inter-laboratory comparison and the introduction of an absolute reference frame4, determination of acid fractionation effects5, correction for the pressure baseline6, as well as improved temperature calibrations2, and most recently new approaches to improve efficiency in terms of sample gas usage7. However, a large-scale application of clumped isotope thermometry is still hampered by required large sample amounts, but also the time-consuming analysis. In general, a lot of time is goes into the measurement of standards. Here we present a study on the optimal ratio between standard- and sample measurements using the Kiel Carbonate Device method. We also consider the optimal initial signal intensity. We analyse ETH-standard measurements from several months to determine the measurement regime with the highest precision and optimised measurement time management.References 1. Eiler, J. M. Earth Planet. Sci. Lett. 262, 309-327 (2007).2. Kelson, J. R., et al. Geochim. Cosmochim. Acta 197, 104-131 (2017).3. Kele, S. et al. Geochim. Cosmochim. Acta 168, 172-192 (2015).4. Dennis, K. J. et al. Geochim. Cosmochim. Acta 75, 7117-7131 (2011).5. Müller, I. A. et al. Chem. Geol. 449, 1-14 (2017).6. Meckler, A. N. et al. Rapid Commun. Mass Spectrom. 28, 1705-1715 (2014).7. Hu, B. et al. Rapid Commun. Mass Spectrom. 28, 1413-1425 (2014).

South African address standard and initiatives towards an international address standard

CSIR Research Space (South Africa)

Cooper, Antony K

2008-10-01

Full Text Available ; visiting friends; and providing a reference context for presenting other information. The benefits of an international address standards include: enabling address interoperability across boundaries; reducing service delivery costs; enabling development...

Quality assurance and quality control in light stable isotope laboratories: A case study of Rio Grande, Texas, water samples

Science.gov (United States)

Coplen, T.B.; Qi, H.

2009-01-01

New isotope laboratories can achieve the goal of reporting the same isotopic composition within analytical uncertainty for the same material analysed decades apart by (1) writing their own acceptance testing procedures and putting them into their mass spectrometric or laser-based isotope-ratio equipment procurement contract, (2) requiring a manufacturer to demonstrate acceptable performance using all sample ports provided with the instrumentation, (3) for each medium to be analysed, prepare two local reference materials substantially different in isotopic composition to encompass the range in isotopic composition expected in the laboratory and calibrated them with isotopic reference materials available from the International Atomic Energy Agency (IAEA) or the US National Institute of Standards and Technology (NIST), (4) using the optimum storage containers (for water samples, sealing in glass ampoules that are sterilised after sealing is satisfactory), (5) interspersing among sample unknowns local laboratory isotopic reference materials daily (internationally distributed isotopic reference materials can be ordered at three-year intervals, and can be used for elemental analyser analyses and other analyses that consume less than 1 mg of material) - this process applies to H, C, N, O, and S isotope ratios, (6) calculating isotopic compositions of unknowns by normalising isotopic data to that of local reference materials, which have been calibrated to internationally distributed isotopic reference materials, (7) reporting results on scales normalised to internationally distributed isotopic reference materials (where they are available) and providing to sample submitters the isotopic compositions of internationally distributed isotopic reference materials of the same substance had they been analysed with unknowns, (8) providing an audit trail in the laboratory for analytical results - this trail commonly will be in electronic format and might include a laboratory

Internationally Comparable Measures of Occupational Status for the 1988 International Standard Classification of Occupations

NARCIS (Netherlands)

Ganzeboom, H.B.G.; Treiman, D.J.

1996-01-01

This paper provides operational procedures for coding internationally comparable measures of occupational status from the recently published International Standard Classification of Occupation 1988 (ISCO88) of the International Labor Office (ILO, 1990). We first discuss the nature of the ISCO88

Standards: An international framework for nuclear safety

International Nuclear Information System (INIS)

Versteeg, J.

2000-01-01

The IAEA, uniquely among international organizations concerned with the use of radiation, radioactive materials and nuclear energy, has statutory functions to establish safety standards and to provide for their application in Member States. The IAEA also contributes towards another major element of the 'global safety culture', namely the establishment of legally binding international agreements on safety related issues. (author)

AUDIT OF FINANCIAL REPORTS, BASED ON INTERNATIONAL ACCOUNTING STANDARDS

OpenAIRE

Islom Kuziev

2011-01-01

In this article are given main notion about international standard of financial reporting, order of the auditing on the base of IFRS, scheduling the report of the auditor, auditor conclusions and are given analysis of reporting based on the auditor procedures. At the audit of financial reporting are taken into account international standard to financial reporting 29 "Financial reporting in hyperinflationary economies".

The performance of single and multi-collector ICP-MS instruments for fast and reliable 34S/32S isotope ratio measurements†

Science.gov (United States)

Pröfrock, Daniel; Irrgeher, Johanna; Prohaska, Thomas

2016-01-01

The performance and validation characteristics of different single collector inductively coupled plasma mass spectrometers based on different technical principles (ICP-SFMS, ICP-QMS in reaction and collision modes, and ICP-MS/MS) were evaluated in comparison to the performance of MC ICP-MS for fast and reliable S isotope ratio measurements. The validation included the determination of LOD, BEC, measurement repeatability, within-lab reproducibility and deviation from certified values as well as a study on instrumental isotopic fractionation (IIF) and the calculation of the combined standard measurement uncertainty. Different approaches of correction for IIF applying external intra-elemental IIF correction (aka standard-sample bracketing) using certified S reference materials and internal inter-elemental IIF (aka internal standardization) correction using Si isotope ratios in MC ICP-MS are explained and compared. The resulting combined standard uncertainties of examined ICP-QMS systems were not better than 0.3–0.5% (uc,rel), which is in general insufficient to differentiate natural S isotope variations. Although the performance of the single collector ICP-SFMS is better (single measurement uc,rel = 0.08%), the measurement reproducibility (>0.2%) is the major limit of this system and leaves room for improvement. MC ICP-MS operated in the edge mass resolution mode, applying bracketing for correction of IIF, provided isotope ratio values with the highest quality (relative combined measurement uncertainty: 0.02%; deviation from the certified value: <0.002%). PMID:27812369

The international development of forensic science standards - A review.

Science.gov (United States)

Wilson-Wilde, Linzi

2018-04-16

Standards establish specifications and procedures designed to ensure products, services and systems are safe, reliable and consistently perform as intended. Standards can be used in the accreditation of forensic laboratories or facilities and in the certification of products and services. In recent years there have been various international activities aiming at developing forensic science standards and guidelines. The most significant initiative currently underway within the global forensic community is the development of International Organization for Standardization (ISO) standards. This paper reviews the main bodies working on standards for forensic science, the processes used and the implications for accreditation. This paper specifically discusses the work of ISO Technical Committee TC272, the future TC272 work program for the development of forensic science standards and associated timelines. Also discussed, are the lessons learnt to date in navigating the complex environment of multi-country stakeholder deliberations in standards development. Crown Copyright © 2018. Published by Elsevier B.V. All rights reserved.

Characterization of a new candidate isotopic reference material for natural Pb using primary measurement method.

Science.gov (United States)

Nonose, Naoko; Suzuki, Toshihiro; Shin, Ki-Cheol; Miura, Tsutomu; Hioki, Akiharu

2017-06-29

A lead isotopic standard solution with natural abundance has been developed by applying a mixture of a solution of enriched 208 Pb and a solution of enriched 204 Pb ( 208 Pb- 204 Pb double spike solution) as bracketing method. The amount-of-substance ratio of 208 Pb: 204 Pb in this solution is accurately measured by applying EDTA titrimetry, which is one of the primary measurement methods, to each enriched Pb isotope solution. Also metal impurities affecting EDTA titration and minor lead isotopes contained in each enriched Pb isotope solution are quantified by ICP-SF-MS. The amount-of-substance ratio of 208 Pb: 204 Pb in the 208 Pb- 204 Pb double spike solution is 0.961959 ± 0.000056 (combined standard uncertainty; k = 1). Both the measurement of lead isotope ratios in a candidate isotopic standard solution and the correction of mass discrimination in MC-ICP-MS are carried out by coupling of a bracketing method with the 208 Pb- 204 Pb double spike solution and a thallium internal addition method, where thallium solution is added to the standard and the sample. The measured lead isotope ratios and their expanded uncertainties (k = 2) in the candidate isotopic standard solution are 18.0900 ± 0.0046 for 206 Pb: 204 Pb, 15.6278 ± 0.0036 for 207 Pb: 204 Pb, 38.0626 ± 0.0089 for 208 Pb: 204 Pb, 2.104406 ± 0.00013 for 208 Pb: 206 Pb, and 0.863888 ± 0.000036 for 207 Pb: 206 Pb. The expanded uncertainties are about one half of the stated uncertainty for NIST SRM 981, for 208 Pb: 204 Pb, 207 Pb: 204 Pb and 206 Pb: 204 Pb, or one eighth, for 208 Pb: 206 Pb and 207 Pb: 206 Pb, The combined uncertainty consists of the uncertainties due to lead isotope ratio measurements and the remaining time-drift effect of mass discrimination in MC-ICP-MS, which is not removed by the coupled correction method. In the measurement of 208 Pb: 204 Pb, 207 Pb: 204 Pb and 206 Pb: 204 Pb, the latter contribution is two or three times larger than the former. When the coupling of

Gas Chromatographic Mass Spectrometric Determination of Myo-inositol in Humans Utilizing a Deuterated Internal Standard

DEFF Research Database (Denmark)

Andersen, Jan Rud; Larsen, Elfinn; Harbo, Helge

1982-01-01

The isotopic dilution technique was used for determining the content of myo-inositol in human urine, plasma and haemolysed erythrocyte samples. A deuterated myo-inositol, synthesized from inosose-2 by base-catalysed exchange of hydrogens by deuterium, followed by reduction of the inosose with 2H2......, was added as internal standard to the samples at an early stage in the analytical procedure. After separation and derivatization to the hexa-acetate, the gas chromatographic mass spectrometric analysis was carried out. A 25 m fused silica capillary column coated with methyl silicone was used, and the ions...... selected for monitoring were m/z 210 and m/z 214, which are characteristic and abundant fragment ions from unlabelled and hexadeuterated myo-inositolhexa-acetate, respectively. Calibration curves from water, urine, plasma and haemolysed erythrocytes show parallel, linear responses in the ratio between...

Beneficial use of isotopes

International Nuclear Information System (INIS)

Bertel, E.; Stevens, G.H.

1998-01-01

The paper gives an outlook on the main isotopes currently used for beneficial applications, provides an overview on geographic distribution of isotope production capabilities and identifies the main suppliers world-wide. It analyses trends in different countries and regions, including the refurbishment and/or replacement of ageing facilities and the implementation of new capabilities. Issues related to adequate supply of isotopes and potential under or over capacity of production for some key products are discussed. The evolution of the isotope production sector is analysed. Issues such as lowering of governmental support to production facilities, emergence of international co-operation and agreements on production capabilities, and developments in non-OECD/NEA countries are addressed. The paper offers some concluding remarks on the importance of maintaining and enhancing beneficial uses of isotopes, the role of government policies, the need for co-operation between countries and between the private and public sectors. The paper addresses the role of international cooperation in making efficient use of existing isotope production capacity and investigates ways for reducing the need for investment in additional capacity. (author)

Lithium isotopic abundances in metal-poor stars: a problem for standard big bang nucleosynthesis?

International Nuclear Information System (INIS)

Nissen, P.E.; Asplund, M.; Lambert, D.L.; Primas, F.; Smith, V.V.

2005-01-01

Spectral obtained with VLT/UVES suggest the existence of the 6 Li isotope in several metal-poor stars at a level that challenges ideas about its synthesis. The 7 Li abundance is, on the other hand, a factor of three lower than predicted by standard Big Bang nucleosynthesis theory. Both problems may be explained if decaying suppersymmetric particles affect the synthesis of light elements in the Big Bang. (orig.)

Thirty years of international nuclear standards in ISO and IEC

International Nuclear Information System (INIS)

Becker, K.

1991-01-01

Of over 4700 nuclear and radiation protection standards, laws, regulations, recommendations, etc., which have been issued by 52 countries and several governmental international organizations such as IAEA, or non-government organizations such as ICRP, ICRU, ISO and IEC, more than 90% are national, and more than half of those of a non-regulatory nature. Both number and importance of international standards are, however, increasing. The two most important non-governmental international standards organizations are the International Organization for Standardization (ISO), which founded a Technical Committee (TC) 85 'Nuclear Energy' with several Sub-Committees in 1957, and the closely associated International Electrotechnical Commission (IEC) with its TC 45 'Nuclear Instrumentation' formed in 1960. There are over 20 member countries actively participating in the work in each of them, with additional observer countries and liaison to the relevant other international organizations. A brief review is given on some of the experience which has been gained by ISO/TC 85 and IEC/TC 45, and its work program and accomplishments, considering in particular recent developments. It covers nuclear safety and instrumentation, radiation protection, and the nuclear fuel cycle, as well as interface issues including definitions and terminology, interaction of the activities with the work of other national and international bodies, etc. Some problem areas are also briefly discussed. (orig.)

46 CFR 199.03 - Relationship to international standards.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Relationship to international standards. 199.03 Section 199.03 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) LIFESAVING APPLIANCES AND ARRANGEMENTS LIFESAVING SYSTEMS FOR CERTAIN INSPECTED VESSELS General § 199.03 Relationship to international...

Results from an interlaboratory exercise on the determination of plutonium isotopic ratios by gamma spectrometry

International Nuclear Information System (INIS)

Ottmar, H.

1981-07-01

Results form interlaboratory comparison measurements on the determination of plutonium isotopic ratios by gamma spectrometry, organized by the ESARDA Working Group on Techniques and Standards for Nondestructive Analysis, are presented and discussed. Nine laboratories from nine countries or international organizations participated in the intercomparison exercise, which included both laboratories' own measurements on the plutonium isotopic reference materials NBS-SRM 946, 947, 948 and comparison analyses of gamma spectra from these materials distributed to the participating laboratories. Results from the intercomparison analyses have been used to reevaluate some gamma branching intensity ratios required for plutonium isotopic ratio measurements. (orig.) [de

An isotope-dilution standard GC/MS/MS method for steroid hormones in water

Science.gov (United States)

Foreman, William T.; Gray, James L.; ReVello, Rhiannon C.; Lindley, Chris E.; Losche, Scott A.

2013-01-01

An isotope-dilution quantification method was developed for 20 natural and synthetic steroid hormones and additional compounds in filtered and unfiltered water. Deuterium- or carbon-13-labeled isotope-dilution standards (IDSs) are added to the water sample, which is passed through an octadecylsilyl solid-phase extraction (SPE) disk. Following extract cleanup using Florisil SPE, method compounds are converted to trimethylsilyl derivatives and analyzed by gas chromatography with tandem mass spectrometry. Validation matrices included reagent water, wastewater-affected surface water, and primary (no biological treatment) and secondary wastewater effluent. Overall method recovery for all analytes in these matrices averaged 100%; with overall relative standard deviation of 28%. Mean recoveries of the 20 individual analytes for spiked reagent-water samples prepared along with field samples analyzed in 2009–2010 ranged from 84–104%, with relative standard deviations of 6–36%. Detection levels estimated using ASTM International’s D6091–07 procedure range from 0.4 to 4 ng/L for 17 analytes. Higher censoring levels of 100 ng/L for bisphenol A and 200 ng/L for cholesterol and 3-beta-coprostanol are used to prevent bias and false positives associated with the presence of these analytes in blanks. Absolute method recoveries of the IDSs provide sample-specific performance information and guide data reporting. Careful selection of labeled compounds for use as IDSs is important because both inexact IDS-analyte matches and deuterium label loss affect an IDS’s ability to emulate analyte performance. Six IDS compounds initially tested and applied in this method exhibited deuterium loss and are not used in the final method.

Study of International Standards of Risk Management

Directory of Open Access Journals (Sweden)

Dykan Volodymyr L.

2014-01-01

Full Text Available The goal of the article lies in the study of existing international standards of risk management, an important factor of improvement of risk management in domestic corporations and enterprises and development of recommendations on application of international standards in Ukraine, in particular, within the framework of building corporate systems of risk management. The conducted study shows that approaches on organisation of the process of risk management, used in standards of risk management, are of general character and differ with the degree of detailing. Their undoubted value in development of risk management in Ukraine is identification of a general direction of building corporate systems of risk management in practice. The said approaches at the national and corporate levels of standardisation in Ukraine within the framework of building corporate systems of risk management would allow improvement of risk management in corporations and enterprises. The prospect of further studies of domestic specialists in the field of risk management is development of the domestic standard of risk management with consideration of modern domestic specific features of development of risk management in Ukraine and leading foreign experience.

Succeeding in process standardization: Explaining the fit with international management strategy

DEFF Research Database (Denmark)

Rahimi, Fatemeh; Møller, Charles; Hvam, Lars

2016-01-01

Purpose: The purpose of this paper is to explore the fit between process standardization and international management strategy of multinational corporations (MNCs) by assessing the compatibility between process standardization and corporate structural characteristics in terms of asset configuration...... and headquarters-subsidiary relationships. Design/methodology/approach: First, after a literature review on MNCs’ strategy and process standardization, the study suggests two propositions on the fit between corporate international management strategy and process standardization. Second, to empirically examine....../value: The study provides in-depth understanding of how the international management strategy and consequent structural characteristics of MNCs affects process standardization in the course of a global enterprise resource planning implementation. The study proposes conditions of fit for aligning process...

Mass spectrometric quantification of glucosylsphingosine in plasma and urine of type 1 Gaucher patients using an isotope standard.

Science.gov (United States)

Mirzaian, Mina; Wisse, Patrick; Ferraz, Maria J; Gold, Henrik; Donker-Koopman, Wilma E; Verhoek, Marri; Overkleeft, Herman S; Boot, Rolf G; Kramer, Gertjan; Dekker, Nick; Aerts, Johannes M F G

2015-04-01

Deficiency of glucocerebrosidase (GBA) leads to Gaucher disease (GD), an inherited disorder characterised by storage of glucosylceramide (GlcCer) in lysosomes of tissue macrophages. Recently, we reported marked increases of deacylated GlcCer, named glucosylsphingosine (GlcSph), in plasma of GD patients. To improve quantification, [5-9] (13)C5-GlcSph was synthesised for use as internal standard with quantitative LC-ESI-MS/MS. The method was validated using plasma of 55 GD patients and 20 controls. Intra-assay variation was 1.8% and inter-assay variation was 4.9% for GlcSph (m/z 462.3). Plasma GlcSph levels with the old and new methods closely correlate (r=0.968, slope=1.038). Next, we analysed GlcSph in 24h urine samples of 30 GD patients prior to therapy. GlcSph was detected in the patient samples (median 1.20nM, range 0.11-8.92nM), but was below the limit of quantification in normal urine. Enzyme replacement therapy led to a decrease of urinary GlcSph of GD patients, coinciding with reductions in plasma GlcSph and markers of Gaucher cells (chitotriosidase and CCL18). In analogy to globotriaosylsphingsone in urine of Fabry disease patients, additional isoforms of GlcSph differing in structure of the sphingosine moiety were identified in GD urine samples. In conclusion, GlcSph can be sensitively detected by LC-ESI-MS/MS with an internal isotope standard. Abnormalities in urinary GlcSph are a hallmark of Gaucher disease allowing biochemical confirmation of diagnosis. Copyright © 2015. Published by Elsevier Inc.

Effect of standards on new equipment design by new international standards and industry restraints

Science.gov (United States)

Endelman, Lincoln L.

1991-01-01

The use of international standards to further trade is one of the objectives of creating a standard. By having form fit and function compatible the free interchange of manufactured goods can be handled without hindrance. Unfortunately by setting up standards that are peculiar to a particular country or district it is possible to exclude competition from a group of manufacturers. A major effort is now underway to develop international laser standards. In the May I 990 issue of Laser Focus World Donald R. Johnson the director of industrial technology services for the National Institute of Standards and Technology (NIST formerly the National Bureau of Standards) is quoted as follows: " The common means of protectionism has been through certification for the market place. " The article goes on to say " Mr. Johnson expects this tradition to continue and that the new European Community (EC) will demand not just safety standards but performance standards as well. . . . the American laser industry must move very quickly on this issue or risk being left behind the European standards bandwagon. " The article continues laser companies must get involved in the actual standards negotiating process if they are to have a say in future policy. A single set of standards would reduce the need to repeatedly recalibrate products for different national markets. " As a member of ISO TC-72 SC9 I am

International Safety Regulation and Standards for Space Travel and Commerce

Science.gov (United States)

Pelton, J. N.; Jakhu, R.

The evolution of air travel has led to the adoption of the 1944 Chicago Convention that created the International Civil Aviation Organization (ICAO), headquartered in Montreal, Canada, and the propagation of aviation safety standards. Today, ICAO standardizes and harmonizes commercial air safety worldwide. Space travel and space safety are still at an early stage of development, and the adoption of international space safety standards and regulation still remains largely at the national level. This paper explores the international treaties and conventions that govern space travel, applications and exploration today and analyzes current efforts to create space safety standards and regulations at the national, regional and global level. Recent efforts to create a commercial space travel industry and to license commercial space ports are foreseen as means to hasten a space safety regulatory process.

Photon and proton activation analysis of iron and steel standards using the internal standard method coupled with the standard addition method

International Nuclear Information System (INIS)

Masumoto, K.; Hara, M.; Hasegawa, D.; Iino, E.; Yagi, M.

1997-01-01

The internal standard method coupled with the standard addition method has been applied to photon activation analysis and proton activation analysis of minor elements and trace impurities in various types of iron and steel samples issued by the Iron and Steel Institute of Japan (ISIJ). Samples and standard addition samples were once dissolved to mix homogeneously, an internal standard and elements to be determined and solidified as a silica-gel to make a similar matrix composition and geometry. Cerium and yttrium were used as an internal standard in photon and proton activation, respectively. In photon activation, 20 MeV electron beam was used for bremsstrahlung irradiation to reduce matrix activity and nuclear interference reactions, and the results were compared with those of 30 MeV irradiation. In proton activation, iron was removed by the MIBK extraction method after dissolving samples to reduce the radioactivity of 56 Co from iron via 56 Fe(p, n) 56 Co reaction. The results of proton and photon activation analysis were in good agreement with the standard values of ISIJ. (author)

Methane clumped isotopes: Progress and potential for a new isotopic tracer

Energy Technology Data Exchange (ETDEWEB)

Douglas, Peter M. J.; Stolper, Daniel A.; Eiler, John M.; Sessions, Alex L.; Lawson, Michael; Shuai, Yanhua; Bishop, Andrew; Podlaha, Olaf G.; Ferreira, Alexandre A.; Santos Neto, Eugenio V.; Niemann, Martin; Steen, Arne S.; Huang, Ling; Chimiak, Laura; Valentine, David L.; Fiebig, Jens; Luhmann, Andrew J.; Seyfried, William E.; Etiope, Giuseppe; Schoell, Martin; Inskeep, William P.; Moran, James J.; Kitchen, Nami

2017-11-01

The isotopic composition of methane is of longstanding geochemical interest, with important implications for understanding hydrocarbon systems, atmospheric greenhouse gas concentrations, the global carbon cycle, and life in extreme environments. Recent analytical developments focusing on multiply substituted isotopologues (‘clumped isotopes’) are opening a potentially valuable new window into methane geochemistry. When methane forms in internal isotopic equilibrium, clumped isotopes can provide a direct record of formation temperature, making this property particularly valuable for identifying different methane origins. However, it has also become clear that in certain settings methane clumped isotope measurements record kinetic rather than equilibrium isotope effects. Here we present a substantially expanded dataset of methane clumped isotope analyses, and provide a synthesis of the current interpretive framework for this parameter. We review different processes affecting methane clumped isotope compositions, describe the relationships between conventional isotope and clumped isotope data, and summarize the types of information that this measurement can provide in different Earth and planetary environments.

Isotope dilution analysis

Energy Technology Data Exchange (ETDEWEB)

Fudge, A.

1978-12-15

The following aspects of isotope dilution analysis are covered in this report: fundamental aspects of the technique; elements of interest in the nuclear field, choice and standardization of spike nuclide; pre-treatment to achieve isotopic exchange and chemical separation; sensitivity; selectivity; and accuracy.

Review of footnotes and annotations to the 1949–2013 tables of standard atomic weights and tables of isotopic compositions of the elements (IUPAC Technical Report)

Science.gov (United States)

Coplen, Tyler B.; Holden, Norman E.

2016-01-01

The Commission on Isotopic Abundances and Atomic Weights uses annotations given in footnotes that are an integral part of the Tables of Standard Atomic Weights to alert users to the possibilities of quite extraordinary occurrences, as well as sources with abnormal atomic-weight values outside an otherwise acceptable range. The basic need for footnotes to the Standard Atomic Weights Table and equivalent annotations to the Table of Isotopic Compositions of the Elements arises from the necessity to provide users with information that is relevant to one or more elements, but that cannot be provided using numerical data in columns. Any desire to increase additional information conveyed by annotations to these Tables is tempered by the need to preserve a compact format and a style that can alert users, who would not be inclined to consult either the last full element-by-element review or the full text of a current Standard Atomic Weights of the Elements report. Since 1989, the footnotes of the Tables of Standard Atomic Weights and the annotations in column 5 of the Table of Isotopic Compositions of the Elements have been harmonized by use of three lowercase footnotes, “g”, “m”, and “r”, that signify geologically exceptionally specimens (“g”), modified isotopic compositions in material subjected to undisclosed or inadvertent isotopic fractionation (“m”), and the range in isotopic composition of normal terrestrial material prevents more precise atomic-weight value being given (“r”). As some elements are assigned intervals for their standard atomic-weight values (applies to 12 elements since 2009), footnotes “g” and “r” are no longer needed for these elements.

An Approach to Establishing International Quality Standards for Medical Travel

Directory of Open Access Journals (Sweden)

Ondřej eKácha

2016-03-01

Full Text Available Traveling abroad to receive a non-elective treatment is expanding each year. Such rising popularity of medical travel and the absence of clear minimum quality requirements in this area urgently calls for setting international standards to ensure good practice and patient safety. The aim of this study is to identify the key domains in medical travel where such quality standards should be established. Drawing from the evidence-based OECD framework and an extensive literature review, this study proposes three critical areas for international quality standards in medical travel: minimum standards of health care facilities and third-party agencies, financial responsibility and patient-centeredness. Several cultural challenges are subsequently introduced that may pose a barrier to the development of the guidelines and should be additionally taken into consideration. Establishing international quality standards in medical travel enhances the benefits to patients and providers, which is urgently needed given the rapid growth in this industry.

on International Financial Reporting Standards

Directory of Open Access Journals (Sweden)

Edyta Łazarowicz

2016-07-01

Full Text Available The article analyses and assesses proposals for changes concerning the objective of financial reportingbased on International Financial Reporting Standards (IFRS, presented in comments on the exposuredraft of the Conceptual Framework for Financial Reporting (2015. The majority of respondents thinkthat the objective of financial reporting should give more prominence to the importance of providinginformation about management’s stewardship. Moreover, some respondents suggest introducing thedefinition of stewardship into the Conceptual Framework and presenting implications of shifts in theobjective of financial reporting for the future standard setting and for preparing financial statements.Based on the analysis of comment letters and the review of accounting literature, the conclusion is thatthe objective of financial reporting should be changed. It is, however, disputable, if stewardship should bea separate object. There is too little research on the relation between the stewardship and decisionusefulnessobjectives. The findings of this research could show accounting standard-setters the potentialtrade-offs and conflicts between these objectives.

12G: code for conversion of isotope-ordered cross-section libraries into group-ordered cross-section libraries

International Nuclear Information System (INIS)

Resnik, W.M. II; Bosler, G.E.

1977-09-01

Many current reactor physics codes accept cross-section libraries in an isotope-ordered form, convert them with internal preprocessing routines to a group-ordered form, and then perform calculations using these group-ordered data. Occasionally, because of storage and time limitations, the preprocessing routines in these codes cannot convert very large multigroup isotope-ordered libraries. For this reason, the I2G code, i.e., ISOTXS to GRUPXS, was written to convert externally isotope-ordered cross section libraries in the standard file format called ISOTXS to group-ordered libraries in the standard format called GRUPXS. This code uses standardized multilevel data management routines which establish a strategy for the efficient conversion of large libraries. The I2G code is exportable contingent on access to, and an intimate familiarization with, the multilevel routines. These routines are machine dependent, and therefore must be provided by the importing facility. 6 figures, 3 tables

Determination of platinum-group elements in the geological standard reference materials by isotope dilution-ICPMS

Energy Technology Data Exchange (ETDEWEB)

Mingyue, Hu; Hongliao, He [National Research Center for Geoanalysis, Beijing (China)

2005-10-15

Platinum group elements (PGEs) includes platinum, palladium, iridium, osmium, rhodium and ruthenium. It has very high economic and scientific value in the field of geoscience and environmental science. But the analysis data referred by the different lab are very disperse because of the difficulty of the determination of PGEs. It makes very difficult to fix the value of the PGEs in the standard reference materials. In the article, the values of the PGEs in the standard reference materials of ocean sediment are determined by isotope dilution technique and dependable values of these elements are provided. (authors)

Determination of platinum-group elements in the geological standard reference materials by isotope dilution-ICPMS

International Nuclear Information System (INIS)

Hu Mingyue; He Hongliao

2005-01-01

Platinum group elements (PGEs) includes platinum, palladium, iridium, osmium, rhodium and ruthenium. It has very high economic and scientific value in the field of geoscience and environmental science. But the analysis data referred by the different lab are very disperse because of the difficulty of the determination of PGEs. It makes very difficult to fix the value of the PGEs in the standard reference materials. In the article, the values of the PGEs in the standard reference materials of ocean sediment are determined by isotope dilution technique and dependable values of these elements are provided. (authors)

THE PARTICIPATION OF INTERNATIONAL ENTITIES ON THE PUBLIC CONSULTATION PROCESS OF PUBLIC INTERNATIONAL ACCOUNTING STANDARD ABOUT INTANGIBLE ASSETS

OpenAIRE

Salaroli, Abner Ribeiro; de Almeida, José Elias Feres; Gama, Janyluce Rezende

2015-01-01

The public accounting follows the same direction of financial accounting on the search for convergence to international standards, where IFAC is the body responsible for issuing international standards of public accounting. In this context, this study aims to analyze the process of development of the international public accounting standard about public intangible assets. The analysis was performed based on the suggestions available in comment letters sent to the consultation process. As a th...

LEASE AGREEMENTS FINANCIAL REPORTING ISSUES ACCORDING TO THE INTERNATIONAL STANDARDS

Directory of Open Access Journals (Sweden)

Marina MAISURADZE

2016-08-01

Full Text Available On January 13th 2016, the Board for International Accounting Standards  published the  new International Standard 16 of Financial Reporting,   named as “Lease”, which will substitute the International Accounting Standard 17 of financial reporting “Lease”. ISFR 16 ensures reflection of practically all lease agreements in the financial reporting, which, in is part, meets the requirements of investors regarding reliability and transparency of the information related to a financial state of an enterprise. The Article considers the changes caused by ISFR 16, which relate to recognition of the lease agreements as the asset, their accounting and, impact on the financial reporting. Relevant conclusions are provided regarding the above mentioned issues.

The upstream oil and gas industry's initiative in the development of international standards

International Nuclear Information System (INIS)

Thomas, G.A.N.; Thorp, G.

1993-01-01

The paper describes the international work of the oil industry to formalize as International Standards many of the industry standards used world-wide. It also describes how matters have been developing in Europe. E and P Forum, representing the international exploration and production oil and gas industry, provides a forum for coordinating industry standardization, to ensure that the necessary standards are maintained by the appropriate technical body. The paper discusses the development of the standardization program in ISO/TC67, the Technical Committee directing the transformation of some 70 API Standards into ISO Standards and the relationship to CEN (the European standardization body). The objective of the upstream industry is to operate worldwide to consistent international standards. Company standards can then concentrate on functional and performance requirements. This will facilitate international trade and communication, open competition and the global market. For a practical realization of this objective the oil industry must foster a special relationship between the relevant US bodies, ISO and CEN. The sustained support of all sides of industry is required

Convergence Of US-GAAP And International Standards: The Critical Issues

OpenAIRE

Steven W. Smalt; John P. McAllister

2011-01-01

This paper provides readers with: 1)An update on an institutional change that will focus the attention of worldwide accounting and financial reporting standard setters on the convergence of international and national standards, and 2)An analysis of in-process issues in the international accounting arena that will be critical to the success / failure of this convergence effort.

Measurement of the natural variation of 13C/12C isotope ratio in organic samples

International Nuclear Information System (INIS)

Ducatti, C.

1977-01-01

The isotopic ratio analysis for 13 C/ 12 C by mass spectrometry using a 'Working standard' allows the study of 13 C natural variation in organic material, with a total analytical error of less than 0,2%. Equations were derived in order to determine 13 C/ 12 C and 18 O/ 16 O ratios related to the 'working standard' CENA-std and to the international standard PDB. Isotope ratio values obtained with samples prepared in two different combustion apparatus were compared; also the values obtained preparing samples by acid decomposition of carbonaceous materials were compared with the values obtained in different international laboratories. Utilizing the methodology proposed, several leaves collected at different heights of different vegetal species, found 'inside' and 'outside' of the Ducke Forest Reserve, located in the Amazon region, are analysed. It is found that the 13 C natural variation depends upon metabolic process and environmental factors, both being factors which may be qualified as parcial influences on the CO 2 cycle in the forest. (author) [pt

International Financial Reporting Standards for SMEs

Directory of Open Access Journals (Sweden)

Cicilia IONESCU

2011-06-01

Full Text Available • IFRS for SMEs give the response to an international requirement of the developed and emerging economies in the process of globalization to have a rigorous and common set of international accounting provisions (standard, rule, regulation specifically for SMEs, to be much more simplified than the complete IFRSs. The area where are applicable the IFRS for SMEs includes all the profit-oriented entities that prepare the general financial statements and do not have the public accountability and there are excluded the entities whose securities are publicly traded and the financial institutions like banks and the insurance companies.

Simultaneous quantification of α-lactalbumin and β-casein in human milk using ultra-performance liquid chromatography with tandem mass spectrometry based on their signature peptides and winged isotope internal standards.

Science.gov (United States)

Chen, Qi; Zhang, Jingshun; Ke, Xing; Lai, Shiyun; Li, Duo; Yang, Jinchuan; Mo, Weimin; Ren, Yiping

2016-09-01

In recent years, there is an increasing need to measure the concentration of individual proteins in human milk, instead of total human milk proteins. Due to lack of human milk protein standards, there are only few quantification methods established. The objective of the present work was to develop a simple and rapid quantification method for simultaneous determination of α-lactalbumin and β-casein in human milk using signature peptides according to a modified quantitative proteomics strategy. The internal standards containing the signature peptide sequences were synthesized with isotope-labeled amino acids. The purity of synthesized peptides as standards was determined by amino acid analysis method and area normalization method. The contents of α-lactalbumin and β-casein in human milk were measured according to the equimolar relationship between the two proteins and their corresponding signature peptides. The method validation results showed a satisfied linearity (R(2)>0.99) and recoveries (97.2-102.5% for α-lactalbumin and 99.5-100.3% for β-casein). The limit of quantification for α-lactalbumin and β-casein was 8.0mg/100g and 1.2mg/100g, respectively. CVs for α-lactalbumin and β-casein in human milk were 5.2% and 3.0%. The contents of α-lactalbumin and β-casein in 147 human milk samples were successfully determined by the established method and their contents were 205.5-578.2mg/100g and 116.4-467.4mg/100g at different lactation stages. The developed method allows simultaneously determination of α-lactalbumin and β-casein in human milk. The quantitative strategy based on signature peptide should be applicable to other endogenous proteins in breast milk and other body fluids. Copyright © 2016 Elsevier B.V. All rights reserved.

International standards to document remaining autonomic function after spinal cord injury

DEFF Research Database (Denmark)

Krassioukov, Andrei; Biering-Sørensen, Fin; Donovan, William

2012-01-01

This is the first guideline describing the International Standards to document remaining Autonomic Function after Spinal Cord Injury (ISAFSCI). This guideline should be used as an adjunct to the International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) including the ...

78 FR 68447 - Exposure Draft-Standards for Internal Control in the Federal Government

Science.gov (United States)

2013-11-14

... GOVERNMENT ACCOUNTABILITY OFFICE Exposure Draft--Standards for Internal Control in the Federal... revisions to the Standards for Internal Control in the Federal Government, known as the ``Green Book,'' to... proposed changes contained in the 2013 Exposure Draft update to the Standards for Internal Control in the...

Forensic analysis of explosives using isotope ratio mass spectrometry (IRMS)--part 1: instrument validation of the DELTAplusXP IRMS for bulk nitrogen isotope ratio measurements.

Science.gov (United States)

Benson, Sarah J; Lennard, Christopher J; Hill, David M; Maynard, Philip; Roux, Claude

2010-01-01

A significant amount of research has been conducted into the use of stable isotopes to assist in determining the origin of various materials. The research conducted in the forensic field shows the potential of isotope ratio mass spectrometry (IRMS) to provide a level of discrimination not achievable utilizing traditional forensic techniques. Despite the research there have been few, if any, publications addressing the validation and measurement uncertainty of the technique for forensic applications. This study, the first in a planned series, presents validation data for the measurement of bulk nitrogen isotope ratios in ammonium nitrate (AN) using the DELTA(plus)XP (Thermo Finnigan) IRMS instrument equipped with a ConFlo III interface and FlashEA 1112 elemental analyzer (EA). Appropriate laboratory standards, analytical methods and correction calculations were developed and evaluated. A validation protocol was developed in line with the guidelines provided by the National Association of Testing Authorities, Australia (NATA). Performance characteristics including: accuracy, precision/repeatability, reproducibility/ruggedness, robustness, linear range, and measurement uncertainty were evaluated for the measurement of nitrogen isotope ratios in AN. AN (99.5%) and ammonium thiocyanate (99.99+%) were determined to be the most suitable laboratory standards and were calibrated against international standards (certified reference materials). All performance characteristics were within an acceptable range when potential uncertainties, including the manufacturer's uncertainty of the technique and standards, were taken into account. The experiments described in this article could be used as a model for validation of other instruments for similar purposes. Later studies in this series will address the more general issue of demonstrating that the IRMS technique is scientifically sound and fit-for-purpose in the forensic explosives analysis field.

Compilation of minimum and maximum isotope ratios of selected elements in naturally occurring terrestrial materials and reagents

Science.gov (United States)

Coplen, T.B.; Hopple, J.A.; Böhlke, J.K.; Peiser, H.S.; Rieder, S.E.; Krouse, H.R.; Rosman, K.J.R.; Ding, T.; Vocke, R.D.; Revesz, K.M.; Lamberty, A.; Taylor, P.; De Bievre, P.

2002-01-01

Documented variations in the isotopic compositions of some chemical elements are responsible for expanded uncertainties in the standard atomic weights published by the Commission on Atomic Weights and Isotopic Abundances of the International Union of Pure and Applied Chemistry. This report summarizes reported variations in the isotopic compositions of 20 elements that are due to physical and chemical fractionation processes (not due to radioactive decay) and their effects on the standard atomic weight uncertainties. For 11 of those elements (hydrogen, lithium, boron, carbon, nitrogen, oxygen, silicon, sulfur, chlorine, copper, and selenium), standard atomic weight uncertainties have been assigned values that are substantially larger than analytical uncertainties because of common isotope abundance variations in materials of natural terrestrial origin. For 2 elements (chromium and thallium), recently reported isotope abundance variations potentially are large enough to result in future expansion of their atomic weight uncertainties. For 7 elements (magnesium, calcium, iron, zinc, molybdenum, palladium, and tellurium), documented isotope-abundance variations in materials of natural terrestrial origin are too small to have a significant effect on their standard atomic weight uncertainties. This compilation indicates the extent to which the atomic weight of an element in a given material may differ from the standard atomic weight of the element. For most elements given above, data are graphically illustrated by a diagram in which the materials are specified in the ordinate and the compositional ranges are plotted along the abscissa in scales of (1) atomic weight, (2) mole fraction of a selected isotope, and (3) delta value of a selected isotope ratio. There are no internationally distributed isotopic reference materials for the elements zinc, selenium, molybdenum, palladium, and tellurium. Preparation of such materials will help to make isotope ratio measurements among

Study on a Threat-Countermeasure Model Based on International Standard Information

Directory of Open Access Journals (Sweden)

Guillermo Horacio Ramirez Caceres

2008-12-01

Full Text Available Many international standards exist in the field of IT security. This research is based on the ISO/IEC 15408, 15446, 19791, 13335 and 17799 standards. In this paper, we propose a knowledge base comprising a threat countermeasure model based on international standards for identifying and specifying threats which affect IT environments. In addition, the proposed knowledge base system aims at fusing similar security control policies and objectives in order to create effective security guidelines for specific IT environments. As a result, a knowledge base of security objectives was developed on the basis of the relationships inside the standards as well as the relationships between different standards. In addition, a web application was developed which displays details about the most common threats to information systems, and for each threat presents a set of related security control policies from different international standards, including ISO/IEC 27002.

Isotope hydrology

International Nuclear Information System (INIS)

Drost, W.

1978-01-01

The International Symposium on Isotope Hydrology was jointly organized by the IAEA and UNESCO, in co-operation with the National Committee of the Federal Republic of Germany for the International Hydrological Programme (IHP) and the Gesellschaft fuer Strahlen- und Umweltforschung mbH (GSF). Upon the invitation of the Federal Republic of Germany the Symposium was held from 19-23 June 1978 in Neuherberg on the GSF campus. The Symposium was officially opened by Mr. S. Eklund, Director General of the IAEA. The symposium - the fifth meeting held on isotope hydrology - was attended by over 160 participants from 44 countries and four international organizations and by about 30 observers from the Federal Republic of Germany. Due to the absence of scientists from the USSR five papers were cancelled and therefore only 46 papers of the original programme were presented in ten sessions

The CMMI Product Suite and International Standards

Science.gov (United States)

2006-07-01

standards: “2.3 Reference Documents 2.3.1 Applicable ISO /IEC documents, including ISO /IEC 12207 and ISO /IEC 15504.” “3.1 Development User Requirements...related international standards such as ISO 9001:2000, 12207 , 15288 © 2006 by Carnegie Mellon University Page 12 Key Supplements Needed...the Measurement Framework in ISO /IEC 15504; and • the Process Reference Model included in ISO /IEC 12207 . A possible approach has been developed for

Measurement of zinc stable isotope ratios in biogeochemical matrices by double-spike MC-ICPMS and determination of the isotope ratio pool available for plants from soil.

Science.gov (United States)

Arnold, Tim; Schönbächler, Maria; Rehkämper, Mark; Dong, Schuofei; Zhao, Fang-Jie; Kirk, Guy J D; Coles, Barry J; Weiss, Dominik J

2010-12-01

Analysis of naturally occurring isotopic variations is a promising tool for investigating Zn transport and cycling in geological and biological settings. Here, we present the recently installed double-spike (DS) technique at the MAGIC laboratories at Imperial College London. The procedure improves on previous published DS methods in terms of ease of measurement and precisions obtained. The analytical method involves addition of a (64)Zn-(67)Zn double-spike to the samples prior to digestion, separation of Zn from the sample matrix by ion exchange chromatography, and isotopic analysis by multiple-collector inductively coupled plasma mass spectrometry. The accuracy and reproducibility of the method were validated by analyses of several in-house and international elemental reference materials. Multiple analyses of pure Zn standard solutions consistently yielded a reproducibility of about ±0.05‰ (2 SD) for δ(66)Zn, and comparable precisions were obtained for analyses of geological and biological materials. Highly fractionated Zn standards analyzed by DS and standard sample bracketing yield slightly varying results, which probably originate from repetitive fractionation events during manufacture of the standards. However, the δ(66)Zn values (all reported relative to JMC Lyon Zn) for two less fractionated in-house Zn standard solutions, Imperial Zn (0.10 ± 0.08‰: 2 SD) and London Zn (0.08 ± 0.04‰), are within uncertainties to data reported with different mass spectrometric techniques and instruments. Two standard reference materials, blend ore BCR 027 and ryegrass BCR 281, were also measured, and the δ(66)Zn were found to be 0.25 ± 0.06‰ (2 SD) and 0.40 ± 0.09‰, respectively. Taken together, these standard measurements ascertain that the double-spike methodology is suitable for accurate and precise Zn isotope analyses of a wide range of natural samples. The newly installed technique was consequently applied to soil samples and soil leachates to

Nuclear data standards - International Evaluation Co-operation volume 7

International Nuclear Information System (INIS)

Carlson, A.D.; Shibata, K.; Vonach, H.; Hambsch, F.J.; Chen, Z.; Hofmann, H.M.; Oh, S.Y.; Badikov, S.A.; Gai, E.V.; Pronyaev, V.G.; Smith, D.L.; Hale, G.M.; Kawano, T.; Larson, N.M.

2006-01-01

A Working Party on International Evaluation Co-operation was established under the sponsorship of the OECD/NEA Nuclear Science Committee (NSC) to promote the exchange of information on nuclear data evaluations, validation and related topics. Its aim is also to provide a framework for co-operative activities between members of the major nuclear data evaluation projects. This includes the possible exchange of scientists in order to encourage co-operation. Requirements for experimental data resulting from this activity are compiled. The working party determines common criteria for evaluated nuclear data files with a view to assessing and improving the quality and completeness of evaluated data. The parties to the project are: ENDF (United States), JEFF/EFF (NEA Data Bank member countries) and JENDL (Japan). Co-operation with evaluation projects of non-OECD countries is organised through the Nuclear Data Section of the International Atomic Energy Agency (IAEA). This report was issued by Subgroup 7, which was in charge of producing new evaluated neutron cross-section standards. When starting the project, there was a general consensus on the need to update these standards, as significant improvements had been made to the experimental database since 1991 when the last evaluation of these standards was performed. The present work was accomplished through efficient collaboration between a task force of the US Cross-section Evaluation Working Group (CSEWG), a Co-ordinated Research Project (CRP) of the International Atomic Energy Agency (IAEA) and Subgroup 7 of the Working Party on International Evaluation Co-operation (WPEC) of the NEA Nuclear Science Committee. Work is reported on the results of an international effort to evaluate the neutron cross-section standards. The evaluations include the H(n,n), 6 Li(n,t), 10 B(n,α), 10 B(n,α1γ), 197 Au(n,γ), 235 U(n,f) and 238 U(n,f) standard reactions. Evaluations were also produced for the non-standard 238 U(n,γ) and 239 Pu

25 CFR 542.7 - What are the minimum internal control standards for bingo?

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What are the minimum internal control standards for bingo... SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.7 What are the minimum internal control standards for... utilized, alternate documentation and/or procedures that provide at least the level of control described by...

Internal correction of spectral interferences and mass bias for selenium metabolism studies using enriched stable isotopes in combination with multiple linear regression.

Science.gov (United States)

Lunøe, Kristoffer; Martínez-Sierra, Justo Giner; Gammelgaard, Bente; Alonso, J Ignacio García

2012-03-01

The analytical methodology for the in vivo study of selenium metabolism using two enriched selenium isotopes has been modified, allowing for the internal correction of spectral interferences and mass bias both for total selenium and speciation analysis. The method is based on the combination of an already described dual-isotope procedure with a new data treatment strategy based on multiple linear regression. A metabolic enriched isotope ((77)Se) is given orally to the test subject and a second isotope ((74)Se) is employed for quantification. In our approach, all possible polyatomic interferences occurring in the measurement of the isotope composition of selenium by collision cell quadrupole ICP-MS are taken into account and their relative contribution calculated by multiple linear regression after minimisation of the residuals. As a result, all spectral interferences and mass bias are corrected internally allowing the fast and independent quantification of natural abundance selenium ((nat)Se) and enriched (77)Se. In this sense, the calculation of the tracer/tracee ratio in each sample is straightforward. The method has been applied to study the time-related tissue incorporation of (77)Se in male Wistar rats while maintaining the (nat)Se steady-state conditions. Additionally, metabolically relevant information such as selenoprotein synthesis and selenium elimination in urine could be studied using the proposed methodology. In this case, serum proteins were separated by affinity chromatography while reverse phase was employed for urine metabolites. In both cases, (74)Se was used as a post-column isotope dilution spike. The application of multiple linear regression to the whole chromatogram allowed us to calculate the contribution of bromine hydride, selenium hydride, argon polyatomics and mass bias on the observed selenium isotope patterns. By minimising the square sum of residuals for the whole chromatogram, internal correction of spectral interferences and mass

Controllable isotope fractionation with thermal ionisation mass-spectrometers

International Nuclear Information System (INIS)

Hebeda, E.H.

1980-01-01

Isotopic ratios measured with thermal ionisation mass-spectrometers are biased by fractionation effects. A sample must therefore be analyzed according to the same procedures as applied for the analysis of the standard reference material. A comparison of the behaviour of the sample with that of the standard can then be used as a criterion whether the analytical results are acceptable or not. In this way it is possible to obtain reproducibilities similar to those for elements acceptable or not. In this way it is possible to obtain reproducibilities similar to those for elements where the fractionation can be determined by an internal standard. This procedure of controlled fractionation is demonstrated by means of the 88 Sr/ 86 Sr ratios measured on geological samples and the SRM 987 standard. (orig.)

International symposium on advances in isotope hydrology and its role in sustainable water resources management (IHS-2007). Book of abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

The quadrennial IAEA isotope hydrology symposia provide an international forum for a comprehensive review of the state of the art and recent advances in this field. The symposia also facilitate the transfer of information, knowledge and interactions between developed and developing countries. Isotopes are increasingly being used to address many of the challenges in sustainable water resources management. The integration of these tools with classical methods and spatial information technologies has been growing rapidly over the past sel years. These have provided unsurpassed capabilities to apply nuclear and geochemical techniques in complex hydrological systems. The main objectives of this symposium are to: - Review the state of the art in isotope hydrology; - Outline recent developments in the application of isotope techniques for water resources management; - Identify future trends and developments for research and applications.

International symposium on advances in isotope hydrology and its role in sustainable water resources management (IHS-2007). Book of abstracts

International Nuclear Information System (INIS)

2007-01-01

The quadrennial IAEA isotope hydrology symposia provide an international forum for a comprehensive review of the state of the art and recent advances in this field. The symposia also facilitate the transfer of information, knowledge and interactions between developed and developing countries. Isotopes are increasingly being used to address many of the challenges in sustainable water resources management. The integration of these tools with classical methods and spatial information technologies has been growing rapidly over the past several years. These have provided unsurpassed capabilities to apply nuclear and geochemical techniques in complex hydrological systems. The main objectives of this symposium are to: - Review the state of the art in isotope hydrology; - Outline recent developments in the application of isotope techniques for water resources management; - Identify future trends and developments for research and applications

Stable Chlorine Isotopes and Elemental Chlorine by Thermal Ionization Mass Spectrometry and Ion Chromatography; Martian Meteorites, Carbonaceous Chondrites and Standard Rocks

Science.gov (United States)

Nakamura, N.; Nyquist, L. E.; Reese, Y.; Shih, C.-Y.; Fujitani, T.; Okano, O.

2011-01-01

Recently significantly large mass fractionation of stable chlorine isotopes has been reported for terrestrial and lunar samples [1,2]. In addition, in view of possible early solar system processes [3] and also potential perchlorate-related fluid/microbial activities on the Martian surface [4,5], a large chlorine isotopic fractionation might be expected for some types of planetary materials. Due to analytical difficulties of isotopic and elemental analyses, however, current chlorine analyses for planetary materials are controversial among different laboratories, particularly between IRMS (gas source mass spectrometry) and TIMS (Thermal Ionization Mass Spectrometry) groups [i.e. 1,6,7] for isotopic analyses, as well as between those doing pyrohydrolysis and other groups [i.e. 6,8]. Additional careful investigations of Cl isotope and elemental abundances are required to confirm real chlorine isotope and elemental variations for planetary materials. We have developed a TIMS technique combined with HF-leaching/ion chromatography at NASA JSC that is applicable to analysis of small amounts of meteoritic and planetary materials. We present here results for several standard rocks and meteorites, including Martian meteorites.

Medical laboratories in sub-Saharan Africa that meet international quality standards.

Science.gov (United States)

Schroeder, Lee F; Amukele, Timothy

2014-06-01

A recent survey of laboratories in Kampala, Uganda, demonstrated that only 0.3% of laboratories (3/954) met international quality standards. To benchmark laboratory quality throughout the rest of sub-Saharan Africa (SSA), we compiled a list of SSA laboratories meeting international quality standards. Accrediting bodies were queried via online registries or direct communication in May 2013. There were 380 laboratories accredited to international standards in SSA. Ninety-one percent were in South Africa. Thirty-seven of 49 countries had no laboratories accredited to international quality standards. Accredited laboratory density (per million people) in South Africa, Namibia, and Botswana were similar to those in many European countries. Single variable linear regression showed a correlation between accredited laboratory density and health expenditures per person (adjusted R(2) = 0.81, P clinical laboratory. For those that do, there is a strong correlation between country-specific accredited laboratory density and per-capita health expenditures. Copyright© by the American Society for Clinical Pathology.

International collaborative study for the calibration of proposed International Standards for thromboplastin, rabbit, plain, and for thromboplastin, recombinant, human, plain.

Science.gov (United States)

van den Besselaar, A M H P; Chantarangkul, V; Angeloni, F; Binder, N B; Byrne, M; Dauer, R; Gudmundsdottir, B R; Jespersen, J; Kitchen, S; Legnani, C; Lindahl, T L; Manning, R A; Martinuzzo, M; Panes, O; Pengo, V; Riddell, A; Subramanian, S; Szederjesi, A; Tantanate, C; Herbel, P; Tripodi, A

2018-01-01

Essentials Two candidate International Standards for thromboplastin (coded RBT/16 and rTF/16) are proposed. International Sensitivity Index (ISI) of proposed standards was assessed in a 20-centre study. The mean ISI for RBT/16 was 1.21 with a between-centre coefficient of variation of 4.6%. The mean ISI for rTF/16 was 1.11 with a between-centre coefficient of variation of 5.7%. Background The availability of International Standards for thromboplastin is essential for the calibration of routine reagents and hence the calculation of the International Normalized Ratio (INR). Stocks of the current Fourth International Standards are running low. Candidate replacement materials have been prepared. This article describes the calibration of the proposed Fifth International Standards for thromboplastin, rabbit, plain (coded RBT/16) and for thromboplastin, recombinant, human, plain (coded rTF/16). Methods An international collaborative study was carried out for the assignment of International Sensitivity Indexes (ISIs) to the candidate materials, according to the World Health Organization (WHO) guidelines for thromboplastins and plasma used to control oral anticoagulant therapy with vitamin K antagonists. Results Results were obtained from 20 laboratories. In several cases, deviations from the ISI calibration model were observed, but the average INR deviation attributabled to the model was not greater than 10%. Only valid ISI assessments were used to calculate the mean ISI for each candidate. The mean ISI for RBT/16 was 1.21 (between-laboratory coefficient of variation [CV]: 4.6%), and the mean ISI for rTF/16 was 1.11 (between-laboratory CV: 5.7%). Conclusions The between-laboratory variation of the ISI for candidate material RBT/16 was similar to that of the Fourth International Standard (RBT/05), and the between-laboratory variation of the ISI for candidate material rTF/16 was slightly higher than that of the Fourth International Standard (rTF/09). The candidate materials

INTERDEPENDENCIES OF THE INTERNAL / MANAGERIAL CONTROL STANDARD NO. 6 - ORGANIZATIONAL STRUCTURE

Directory of Open Access Journals (Sweden)

Ionut-Cosmin BĂLOI

2015-06-01

Full Text Available Our initiative of analyzing the internal control standard which deals with the organizational structure comes from the observations on the significance of these essential aspects of modern management and on the sensitivity with which this standard is treated in most of the public institutions considered representative for the Oltenia region. Although the administrators of public institutions strive to optimize the systems of internal/managerial control, they frequently face many issues concerning the misunderstanding of these standards, vaguely explained, for example throughout some guidelines or other documents. The hypothesis of our study is that most of public institutions face gaps in understanding, interpreting, adapting and implementing an effective model of organizational structure, and the causes are due to the lack of an interdependent, correlated approach of the pillars that support the internal/managerial control system: the 25 standards required by the Romanian legislation. Our study critically describes the superficial approach founded in the self-evaluation reports of the public institutions, if we refer only to the conformity of the organizational structure and the four standards that we consider inextricably related with this internal/managerial control standard. From the methodological point of view, our study tests the correlation between the level of compliance of these standards and the functionality of the system composed by them in the public organizations that we have investigated.

77 FR 37361 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2012-06-21

... National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines; New Source Performance Standards for Stationary Internal Combustion Engines AGENCY: Environmental Protection... Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines; New Source Performance...

Domestic and International Nuclear Energy Voluntary Consensus Standards Needs

International Nuclear Information System (INIS)

Hopper, Calvin Mitchell

2013-01-01

This report introduces the reader to the domestic and international standards development organizations (SDOs) and their structures and operations. It also identifies some of the support and subject matter needs for the development of standards on the subject of nuclear energy. The support needs are described with regard to organizational structure and subject-matter-expert (SME) participation that is required for producing voluntary consensus standards. The subject matter needs are described with regard to growing technologies and objectives that approach the boundaries of existing standards; implementation of knowledge; and safety of people, facilities, and the environment. Standards are proposed, developed, and produced by SMEs with the support of industry and government organizations. The voluntary consensus standards development process is, as its name implies, a voluntary effort. The problem in today's competitive market, impacted by global economic uncertainty, is that the voluntary participation is shifting from a collaborative industry and SME effort to a nearly SME-only one. This shift places a financial and/or time burden on the SMEs to the point that they are purposely withdrawing from the standards development process, both domestically and internationally. The standards development process desperately needs participation from more and younger SMEs. The report includes several suggestions on how this can be addressed.

Standardization for oxygen isotope ratio measurement - still an unsolved problem.

Science.gov (United States)

Kornexl; Werner; Gehre

1999-07-01

Numerous organic and inorganic laboratory standards were gathered from nine European and North American laboratories and were analyzed for their delta(18)O values with a new on-line high temperature pyrolysis system that was calibrated using Vienna standard mean ocean water (VSMOW) and standard light Antartic precipitation (SLAP) internationally distributed reference water samples. Especially for organic materials, discrepancies between reported and measured values were high, ranging up to 2 per thousand. The reasons for these discrepancies are discussed and the need for an exact and reliable calibration of existing reference materials, as well as for the establishment of additional organic and inorganic reference materials is stressed. Copyright 1999 John Wiley & Sons, Ltd.

Measurement control for plutonium isotopic measurements using gamma-ray spectrometry

International Nuclear Information System (INIS)

Fleissner, J.G.

1985-01-01

A measurement control (MC) program should be an integral part of every nondestructive assay measurement system used for the assay of special nuclear materials. This report describes an MC program for plutonium isotopic composition measurements using high-resolution gamma-ray spectroscopy. This MC program emphasizes the standardization of data collection procedures along with the implementation of internal and external measurement control checks to provide the requisite measurement quality assurance. This report also describes the implementation of the MC program in the isotopic analysis code GRPAUT. Recommendations are given concerning the importance and frequency of the various MC checks in order to ensure a successful implementation of the MC procedures for the user's application

International standards for monoclonal antibodies to support pre- and post-marketing product consistency: Evaluation of a candidate international standard for the bioactivities of rituximab.

Science.gov (United States)

Prior, Sandra; Hufton, Simon E; Fox, Bernard; Dougall, Thomas; Rigsby, Peter; Bristow, Adrian

2018-01-01

The intrinsic complexity and heterogeneity of therapeutic monoclonal antibodies is built into the biosimilarity paradigm where critical quality attributes are controlled in exhaustive comparability studies with the reference medicinal product. The long-term success of biosimilars will depend on reassuring healthcare professionals and patients of consistent product quality, safety and efficacy. With this aim, the World Health Organization has endorsed the need for public bioactivity standards for therapeutic monoclonal antibodies in support of current controls. We have developed a candidate international potency standard for rituximab that was evaluated in a multi-center collaborative study using participants' own qualified Fc-effector function and cell-based binding bioassays. Dose-response curve model parameters were shown to reflect similar behavior amongst rituximab preparations, albeit with some differences in potency. In the absence of a common reference standard, potency estimates were in poor agreement amongst laboratories, but the use of the candidate preparation significantly reduced this variability. Our results suggest that the candidate rituximab standard can support bioassay performance and improve data harmonization, which when implemented will promote consistency of rituximab products over their life-cycles. This data provides the first scientific evidence that a classical standardization exercise allowing traceability of bioassay data to an international standard is also applicable to rituximab. However, we submit that this new type of international standard needs to be used appropriately and its role not to be mistaken with that of the reference medicinal product.

25 CFR 542.14 - What are the minimum internal control standards for the cage?

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What are the minimum internal control standards for the... SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.14 What are the minimum internal control standards for... and/or procedures that provide at least the level of control described by the standards in this...

25 CFR 542.8 - What are the minimum internal control standards for pull tabs?

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What are the minimum internal control standards for pull... SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.8 What are the minimum internal control standards for... and/or procedures that provide at least the level of control described by the standards in this...

77 FR 33811 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2012-06-07

... 63 National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines; New Source Performance Standards for Stationary Internal Combustion Engines; Proposed Rule #0;#0... Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines; New Source...

Book of abstracts of the fourth international school for young scientists and specialists Interaction of hydrogen isotopes with structural materials (IHISM-08)

International Nuclear Information System (INIS)

2008-01-01

The book includes abstracts of presentations at the 4th International School for young scientists and specialists Interaction of hydrogen isotopes with structural materials (IHISM-08). The lectures of lecturer and presentations of young scientists associated with the use of hydrogen isotopes in power engineering, national economy and basic research are considered. The presentations cover the following areas: kinetics and thermodynamics of interaction between hydrogen isotopes and solids including effects of radiogenic helium accumulation; hydrides and hydride transformations; structural transformations and mechanical properties; equipment and research techniques [ru

Isotopic effects in the neon fixed point: uncertainty of the calibration data correction

Science.gov (United States)

Steur, Peter P. M.; Pavese, Franco; Fellmuth, Bernd; Hermier, Yves; Hill, Kenneth D.; Seog Kim, Jin; Lipinski, Leszek; Nagao, Keisuke; Nakano, Tohru; Peruzzi, Andrea; Sparasci, Fernando; Szmyrka-Grzebyk, Anna; Tamura, Osamu; Tew, Weston L.; Valkiers, Staf; van Geel, Jan

2015-02-01

The neon triple point is one of the defining fixed points of the International Temperature Scale of 1990 (ITS-90). Although recognizing that natural neon is a mixture of isotopes, the ITS-90 definition only states that the neon should be of ‘natural isotopic composition’, without any further requirements. A preliminary study in 2005 indicated that most of the observed variability in the realized neon triple point temperatures within a range of about 0.5 mK can be attributed to the variability in isotopic composition among different samples of ‘natural’ neon. Based on the results of an International Project (EUROMET Project No. 770), the Consultative Committee for Thermometry decided to improve the realization of the neon fixed point by assigning the ITS-90 temperature value 24.5561 K to neon with the isotopic composition recommended by IUPAC, accompanied by a quadratic equation to take the deviations from the reference composition into account. In this paper, the uncertainties of the equation are discussed and an uncertainty budget is presented. The resulting standard uncertainty due to the isotopic effect (k = 1) after correction of the calibration data is reduced to (4 to 40) μK when using neon of ‘natural’ isotopic composition or to 30 μK when using 20Ne. For comparison, an uncertainty component of 0.15 mK should be included in the uncertainty budget for the neon triple point if the isotopic composition is unknown, i.e. whenever the correction cannot be applied.

The main requirements of the International Basic Safety Standards

International Nuclear Information System (INIS)

Webb, G.A.M.

1998-01-01

The main requirements of the new international basic safety standards are discussed, including such topics as health effects of ionizing radiations, the revision of basic safety standards, the requirements for radiation protection practices, the requirements for intervention,and the field of regulatory infrastructures. (A.K.)

Isotope dilution analysis for urinary fentanyl and its main metabolite, norfentanyl, in patients by isotopic fractionation using capillary gas chromatography

Energy Technology Data Exchange (ETDEWEB)

Sera, Shoji; Goromaru, Tsuyoshi [Fukuyama Univ., Hiroshima (Japan). Faculty of Pharmacy and Pharmaceutical Sciences; Sameshima, Teruko; Kawasaki, Koichi; Oda, Toshiyuki

1998-07-01

Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID). Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT-{sup 2}H{sub 19}), as an internal standard. We also performed isotope dilution analysis of Nor-FT in urine. N-Alkylation was necessary to sensitively detect Nor-FT with SID. Methyl derivative was selected from 3 kinds of N-alkyl derivatives to increase sensitivity and peak resolution, and to prevent interference with urinary compound. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT-{sup 2}H{sub 10}). No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism. (author)

Isotope dilution analysis for urinary fentanyl and its main metabolite, norfentanyl, in patients by isotopic fractionation using capillary gas chromatography

International Nuclear Information System (INIS)

Sera, Shoji; Goromaru, Tsuyoshi; Sameshima, Teruko; Kawasaki, Koichi; Oda, Toshiyuki

1998-01-01

Isotope dilution analysis was applied to determine urinary excretion of fentanyl (FT) and its main metabolite, norfentanyl (Nor-FT), by isotopic fractionation using a capillary gas chromatograph equipped with a surface ionization detector (SID). Urinary FT was determined quantitatively in the range of 0.4-40 ng/ml using deuterium labeled FT (FT- 2 H 19 ), as an internal standard. We also performed isotope dilution analysis of Nor-FT in urine. N-Alkylation was necessary to sensitively detect Nor-FT with SID. Methyl derivative was selected from 3 kinds of N-alkyl derivatives to increase sensitivity and peak resolution, and to prevent interference with urinary compound. Nor-FT concentration was quantitatively determined in the range of 10-400 ng/ml using deuterium labeled Nor-FT (Nor-FT- 2 H 10 ). No endogenous compounds or concomitant drugs interfered with the detection of FT and Nor-FT in the urine of patients. The present method will be useful for pharmacokinetic studies and the evaluation of drug interactions in FT metabolism. (author)

Food certification based on isotopic analysis, according to the European standards

International Nuclear Information System (INIS)

Costinel, Diana; Ionete, Roxana Elena; Vremera, Raluca; Stanciu, Vasile; Iordache, Andreea

2007-01-01

Full text: Under current EU research projects, several public research institutions, universities and private companies are collaborating to develop new methods of evidencing food adulteration and consequently assessing food safety. The use of mass spectrometry (MS) to determine the ratio of stable isotopes in bio-molecules now provides the means to prove the natural origin of a wide variety of foodstuffs - and therefore, to identify the fraud and consequently to reject the improper products or certify the food quality. Isotope analysis has been officially adopted by the EU as a means of controlling adulteration of some food stuffs. A network of research organizations developed the use of isotopic analysis to support training and technology transfer to encourage uptake of the technique. There were also developed proficiency-testing schemes to ensure the correct use of isotopic techniques in national testing laboratories. In addition, ensuring the food quality and safety is a requirement, which must be fulfilled for the integration in EU. The present paper emphasizes the isotopic analysis for D/H, 18 O/ 16 O, 13 C/ 12 C from food (honey, juice, wines) using a new generation Isotope Ratio MS, Finnigan Delta V Plus, coupled to a three flexible continuous flow preparation device (GasBench II, TC Elemental Analyser and GC-C/TC). (authors)

The International Accounting Standards Board’s Progress in Promoting Judgement Through Objectives-Oriented Accounting Standards

Directory of Open Access Journals (Sweden)

Tanja Lakovic

2013-07-01

Full Text Available This study analyzes how the International Accounting Standards Board (IASB promotes professional judgement by issuing objectives-oriented accounting standards and exposure drafts.  We focus on the the role of judgement as outlined in Phase I of the IASB Conceptual Framework (CF, Chapter 1, “Objective of General Purpose Financial Statements” and Chapter 3, “Qualitative Characteristics of Useful Financial Information” (IASB 2010. We discuss how the framework, when viewed through the prism of 'objectives-oriented accounting standards' as recommended by the United States Securities and Exchange Commission (SEC Report in its “Study Pursuant to Section 108(d of the Sarbanes-Oxley Act of 2002 on the Adoption by the United States Financial Reporting System of a Principles-Based Accounting System” (July 2003, encourages professional judgement. We analyze International Financial Reporting Standards (IFRS and Exposure Drafts (ED issued by the IASB since its inception in 2002 to determine if those documents are consistent with objectives-oriented accounting standards. Our analysis is useful for gaining insights into how the IASB integrates the CF with the SEC’s recommended objectives-oriented accounting approach to promote judgement in the interest of IASB/FASB convergence of accounting standards.

International Reserves Crises, Monetary Integration and the Payments System during the International Gold Standard

OpenAIRE

Paula Hernandez-Verme

2009-01-01

I model an international payments system with a financial center and periphery to reproduce various aspects of the International Gold Standard. This period was characterized by frequent crises associated with scarce stocks of reserves, high short-term interest rates with subsequent gold inflows and transmission of output contractions across countries. I find that a common international currency and no legal restrictions on exchange help the periphery share reserves with the financial center, ...

International Financial Reporting standard for Small and Medium-sized entities

Directory of Open Access Journals (Sweden)

Z Koppeschaar

2012-12-01

Full Text Available The International Financial Reporting Standard for Small and Medium-sized entities (IFRS for SMEs was published as a standard by the International Accounting Standards Board (IASB during July 2009. During 2007 South Africa became one of the first countries and the first country in Africa to early accept the proposed accounting standard (exposure draft of an IFRS for SMEs. The accounting standard will probably also be accepted by numerous other countries. The aim of this article is to investigate the applicability of this accounting standard. The results indicated that the IFRS for SMEs remains too comprehensive for the majority of small companies. The IFRS for SMEs does not satisfy the needs of South African users of small company financial statements, and as a result the accounting requirements should be simplified. KEYWORDS: Financial accounting; Financial reporting requirements; IFRS for SMEs; Small companies; Users of financial statements; Small company financial statements.

Developing Potential New Reference Materials for Light Isotopes in Foodstuffs

Science.gov (United States)

Frew, Russell; Van Hale, Robert; Clarke, Dianne; Abrahim, Aiman; Resch, Christian; Mayr, Leopold; Cannavan, Andrew; Gröning, Manfred

2013-04-01

Measurements of subtle variations in stable isotope ratios provide the means for verifying food integrity in numerous ways. Adulterants usually have different isotopic composition so their presence in a food is readily detectable. Stable isotope measurements can also be used to determine the region of production of the food. In most cases the ability of stable isotope measurements to verify, or otherwise reject, the authenticity of the food is greatly enhanced by comparison of a result to a reference database. The more high-quality data in the database, the more statistical power is afforded by the comparison. A serious weakness at present is the lack of reference materials in food matrices available to the community. Thus researchers have to rely on in-house standards for calibration and quality assurance. The result is that there are numerous datasets published that may be internally consistent but it is exceedingly difficult to combine these datasets into a cohesive database. This is particularly important for measurements of the hydrogen isotopes. Here we present a survey of the stable isotope (^2H, ^13C and ^15N) composition of 12 Reference Materials from the International Atomic Energy Agency catalogue. All but one of these materials are plant matter and have been developed as reference materials for other applications such as radionuclide or trace element measurements. Thus they have been verified as suitable materials in terms of stability and homogeneity for those tests. The purpose of this work is to ascertain if they are similarly suitable as stable isotope reference materials. The results from our survey show that there is a wide range in elemental and isotopic composition among these materials. For example, the ^15N values range from-13.5‰ to +18.6‰ and the nitrogen elemental composition range is from 0.7% to 9.7%. The ^13C values range from -20‰ to -40‰ and the carbon elemental composition ranges from 15% to 47%. We are now in the process of

Book of abstracts of the Fifth International School for young scientists and specialists Interaction of hydrogen isotopes with structural materials. IHISM-09 JUNIOR

International Nuclear Information System (INIS)

2009-01-01

The book includes abstracts of presentations at the Fifth International School for young scientists and specialists Interaction of hydrogen isotopes with structural materials (IHISM-09 JUNIOR). Abstracts of lecture faculty and reports of young scientists and specialists covering the use of hydrogen isotopes in energetics, national economy and fundamental researches are given. Papers presented on the following topics: mechanical properties and structural transformations; kinetics and thermodynamics of interaction between hydrogen isotopes and solids including effects of radiogenic helium accumulation, hydrides and hydride transformations; equipment and research techniques

The quantitative analysis of Bowen's kale by PIXE using the internal standard

International Nuclear Information System (INIS)

Navarrete, V.R.; Izawa, G.; Shiokawa, T.; Kamiya, M.; Morita, S.

1978-01-01

The internal standard method was used for non-destructive quantitative determination of trace elements by PIXE. The uniform distribution of the internal standard element in the Bowen's kale powder sample was obtained by using homogenization technique. Eleven elements are determined quantitatively for the sample prepared into self-supporting targets having lower relative standard deviations than non-self-supporting targets. (author)

Human Rights and Values Education: Using the International Standards.

Science.gov (United States)

Reardon, Betty A.

1994-01-01

Asserts that, in teaching about human rights, the international standards should be the fundamental core of the content and values to be communicated. Recommends that teachers should use the Universal Declaration of Human Rights as the standard by which the actions of individuals and governments should be compared. (CFR)

International developments. Research and standardization; Internationale Entwicklungen. Forschung und Standardisierung

Energy Technology Data Exchange (ETDEWEB)

Breustedt, Bastian [Karlsruher Institut fuer Technologie (KIT), Eggenstein-Leopoldshafen (Germany). Inst. fuer Strahlenforschung

2017-08-01

The methods and models for the determination of incorporated doses are developed and published by the international radiation protection commission ICRP. The ICRP recommendations were adopted into the international basic safety standards of IAEA and the European Commission The implementation of the safety standards into the national radiation protection regulations yield the legal basis for incorporation surveillance. In Germany this is the Strahlenschutzverordnung and the guideline for the physical radiation protection control for the determination of body doses.

Stable carbon isotope ratio profiling of illicit testosterone preparations--domestic and international seizures.

Science.gov (United States)

Brooker, Lance; Cawley, Adam; Drury, Jason; Edey, Claire; Hasick, Nicole; Goebel, Catrin

2014-10-01

Gas chromatography-combustion-isotope ratio mass spectrometry (GC-C-IRMS) is now established as a robust and mature analytical technique for the doping control of endogenous anabolic androgenic steroids in human sport. It relies on the assumption that the carbon isotope ratios of naturally produced steroids are significantly different to synthetically manufactured testosterone or testosterone prohormones used in commercial medical or dietary supplement products. Recent publications in this journal have highlighted the existence of black market testosterone preparations with carbon isotope ratios within the range reported for endogenous steroids (i.e. δ(13) C ≥ -25.8 ‰). In this study, we set out to profile domestic and international law enforcement seizures of illicit testosterone products to monitor the prevalence of 'enriched' substrates--which if administered to human subjects would be considered problematic for the use of current GC-C-IRMS methodologies for the doping control of testosterone in sport. The distribution of δ(13) C values for this illicit testosterone sample population (n = 283) ranged from -23.4 ‰ to -32.9 ‰ with mean and median of -28.6 ‰--comparable to previous work. However, only 13 out of 283 testosterone samples (4.6 %) were found to display δ(13) C values ≥ -25.8 ‰, confirming that in the vast majority of cases of illicit testosterone administration, current GC-C-IRMS doping control procedures would be capable of confirming misuse. Copyright © 2014 John Wiley & Sons, Ltd.

Standard methods for sampling freshwater fishes: Opportunities for international collaboration

Science.gov (United States)

Bonar, Scott A.; Mercado-Silva, Norman; Hubert, Wayne A.; Beard, Douglas; Dave, Göran; Kubečka, Jan; Graeb, Brian D. S.; Lester, Nigel P.; Porath, Mark T.; Winfield, Ian J.

2017-01-01

With publication of Standard Methods for Sampling North American Freshwater Fishes in 2009, the American Fisheries Society (AFS) recommended standard procedures for North America. To explore interest in standardizing at intercontinental scales, a symposium attended by international specialists in freshwater fish sampling was convened at the 145th Annual AFS Meeting in Portland, Oregon, in August 2015. Participants represented all continents except Australia and Antarctica and were employed by state and federal agencies, universities, nongovernmental organizations, and consulting businesses. Currently, standardization is practiced mostly in North America and Europe. Participants described how standardization has been important for management of long-term data sets, promoting fundamental scientific understanding, and assessing efficacy of large spatial scale management strategies. Academics indicated that standardization has been useful in fisheries education because time previously used to teach how sampling methods are developed is now more devoted to diagnosis and treatment of problem fish communities. Researchers reported that standardization allowed increased sample size for method validation and calibration. Group consensus was to retain continental standards where they currently exist but to further explore international and intercontinental standardization, specifically identifying where synergies and bridges exist, and identify means to collaborate with scientists where standardization is limited but interest and need occur.

Application of Stable Isotope in Detection of Veterinary Drug Residues

International Nuclear Information System (INIS)

Wang Wei; Liu Zhanfeng; Du Xiaoning

2010-01-01

In recent years, there has happened a series of significant food safety events worldwide, which lower down consumers' confidence in food safety, and they are taking increasing care about the sources of their foods. The safety problem of animal-origin foods has become a global topic for discussion. Therefore, it is a pressing task to establish a precise, sensitive and reliable method for analyzing veterinary drug residue. An introduction of the present status regarding veterinary drug residue analysis was made in the paper, and it briefly summarized the limit of detection (LOD) and quantification (LOQ) which could be reached in veterinary drug residue analysis by isotopic internal standard method domestically and abroad. The paper also made a review of the progress in applied research of stable isotope labeled compound in veterinary drug residue analysis of, such as, antibiotic medicines, furans and sulfonamides. The paper elucidated the great importance of the application of stable isotopes in the sane development of China's food safety system. (authors)

Development of Stable Isotope Technology

International Nuclear Information System (INIS)

Jeong, Do Young; Kim, Cheol Jung; Han, Jae Min

2009-03-01

KAERI has obtained an advanced technology with singular originality for laser stable isotope separation. Objectives for this project are to get production technology of Tl-203 stable isotope used for medical application and are to establish the foundation of the pilot system, while we are taking aim at 'Laser Isotope Separation Technology to make resistance to the nuclear proliferation'. And we will contribute to ensuring a nuclear transparency in the world society by taking part in a practical group of NSG and being collaboration with various international groups related to stable isotope separation technology

Convergence Between Kazakhstan’S Financial Systemand International Standards: Overcoming Difficulties

Directory of Open Access Journals (Sweden)

Uvarova Natalya

2015-06-01

Full Text Available This article deals with the convergence of the Kazakh financial system with international standards in light of the new, enhanced agreement with the European Union on partnership and cooperation (January 19, 2015. Based on this research, the approaches used by the Kazakh financial system to converge with the European Union (EU and the mechanism of implementing international standards in the national regulatory framework are determined. In practice, the study provides justification for the necessity of arranging the systematization of existing rules and regulations covering financial activity in the Republic, eliminating discrepancies between the national regulatory framework and international standards, and determining clear security guarantees for foreign investors’ financial activity in the Republic. The research results are primarily focused on the development of public finance management theory. Theories and conclusions present in the study can be used in the educational processes of economic and legal institutions and in the policymaking activity of public finance management bodies.

Reassessment of the NH4 NO3 thermal decomposition technique for calibration of the N2 O isotopic composition.

Science.gov (United States)

Mohn, Joachim; Gutjahr, Wilhelm; Toyoda, Sakae; Harris, Eliza; Ibraim, Erkan; Geilmann, Heike; Schleppi, Patrick; Kuhn, Thomas; Lehmann, Moritz F; Decock, Charlotte; Werner, Roland A; Yoshida, Naohiro; Brand, Willi A

2016-09-08

In the last few years, the study of N 2 O site-specific nitrogen isotope composition has been established as a powerful technique to disentangle N 2 O emission pathways. This trend has been accelerated by significant analytical progress in the field of isotope-ratio mass-spectrometry (IRMS) and more recently quantum cascade laser absorption spectroscopy (QCLAS). Methods The ammonium nitrate (NH 4 NO 3 ) decomposition technique provides a strategy to scale the 15 N site-specific (SP ≡ δ 15 N α - δ 15 N β ) and bulk (δ 15 N bulk  = (δ 15 N α  + δ 15 N β )/2) isotopic composition of N 2 O against the international standard for the 15 N/ 14 N isotope ratio (AIR-N 2 ). Within the current project 15 N fractionation effects during thermal decomposition of NH 4 NO 3 on the N 2 O site preference were studied using static and dynamic decomposition techniques. The validity of the NH 4 NO 3 decomposition technique to link NH 4 + and NO 3 - moiety-specific δ 15 N analysis by IRMS to the site-specific nitrogen isotopic composition of N 2 O was confirmed. However, the accuracy of this approach for the calibration of δ 15 N α and δ 15 N β values was found to be limited by non-quantitative NH 4 NO 3 decomposition in combination with substantially different isotope enrichment factors for the conversion of the NO 3 - or NH 4 + nitrogen atom into the α or β position of the N 2 O molecule. The study reveals that the completeness and reproducibility of the NH 4 NO 3 decomposition reaction currently confine the anchoring of N 2 O site-specific isotopic composition to the international isotope ratio scale AIR-N 2 . The authors suggest establishing a set of N 2 O isotope reference materials with appropriate site-specific isotopic composition, as community standards, to improve inter-laboratory compatibility. This article is protected by copyright. All rights reserved.

Stable isotope quality assurance using the 'calibrated IRMS' strategy.

Science.gov (United States)

Meijer, Harro A J

2009-06-01

Procedures in our laboratory have always been directed towards complete understanding of all processes involved and corrections needed etc., instead of relying fully on laboratory reference materials. This rather principal strategy (or attitude) is probably not optimal in the economic sense, and is not necessarily more accurate either. Still, it has proven to be very rewarding in its capability to detect caveats that go undiscovered in the standard way of measurement, but that do influence the accuracy or reliability of the measurement procedure. An additional benefit of our laboratory procedures is that it makes us capable of assisting the International Atomic Energy Agency (IAEA) with primary questions like mutual scale assignments and comparison of isotope ratios of the same isotope in different matrices (like delta(18)O in water, carbonates and atmospheric CO(2)), establishment of the (17)O-(18)O relation, and the replenishment of the calibration standards. Finally, for manual preparation systems with a low sample throughput (and thus only few reference materials analysed) it may well be the only way to produce reliable results.

Spectral determination of thallium isotope composition

International Nuclear Information System (INIS)

Polyanskij, V.A.; Turkin, Yu.I.; Yakimova, N.M.

1986-01-01

The photoelectric non-standard method for determination of the thallium isotope composition is developed. The analysis is carried out by measuring the brightness of the Hfs components in the line Tl Iλ535.04 nm. The relative standard deviation of the results of the isotope analysis of thallium as metal is 0.02 and of thallium salts - 0.02-0.05

International Financial Reporting Standards Convergence and Quality of Accounting Information: Evidence from Indonesia

OpenAIRE

Yusrina, Hasyyati; Mukhtaruddin, Mukhtaruddin; Fuadah, Luk Luk; Sulong, Zunaidah

2017-01-01

The International Financial Reporting Standards (IFRS) initiated by International Accounting Standard Board (IASB) are principle-based standard that require extensive disclosure of financial statements and accounting information as compared to prior standard that is the Generally Accepted Accounting Principles (GAAP) to better reflect the overall quality of company’s performance. Therefore, the IFRS convergence is expected to improve the reliability of financial reporting by limiting opportun...

International Standards Development for Marine and Hydrokinetic Renewable Energy - Final Report on Technical Status

Energy Technology Data Exchange (ETDEWEB)

Rondorf, Neil E.; Busch, Jason; Kimball, Richard

2011-10-29

This report summarizes the progress toward development of International Standards for Marine and Hydrokinetic Renewable Energy, as funded by the U.S. Department of Energy (DOE) under the International Electrotechnical Commission (IEC) Technical Committee 114. The project has three main objectives: 1. Provide funding to support participation of key U.S. industry technical experts in 6 (originally 4) international working groups and/or project teams (the primary standards-making committees) and to attend technical meetings to ensure greater U.S. involvement in the development of these standards. 2. Provide a report to DOE and industry stakeholders summarizing the IEC standards development process for marine and hydrokinetic renewable energy, new international standards and their justifications, and provide standards guidance to industry members. 3. Provide a semi-annual (web-based) newsletter to the marine renewable energy community. The newsletter will educate industry members and stakeholders about the processes, progress, and needs of the US efforts to support the international standards development effort. The newsletter is available at www.TC114.us

77 FR 60341 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2012-10-03

... National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines; New Source Performance Standards for Stationary Internal Combustion Engines AGENCY: Environmental Protection... Pollutants for Stationary Reciprocating Internal Combustion Engines to solicit comment on specific issues...

78 FR 54606 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2013-09-05

... Combustion Engines; New Source Performance Standards for Stationary Internal Combustion Engines AGENCY... hazardous air pollutants for stationary reciprocating internal combustion engines and the standards of performance for stationary internal combustion engines. Subsequently, the EPA received three petitions for...

International standardization of nuclear reactor designs - the way forward

International Nuclear Information System (INIS)

Raetzke, Christian

2010-01-01

The concept of 'International Standardization of Nuclear Reactor Designs' means that vendors could build their designs in every country without having to adapt it specifically to national safety requirements. Such standardization would have two main effects. It would greatly facilitate nuclear new build worldwide by giving greater efficiency and certainty to the national licensing procedures; by taking into account the fact that vendors, and nowadays also utilities, are active across borders; by helping developing countries to establish their nuclear new build programmes; and by reducing the strain on human resources on both the regulators' and the industry's side. The second valuable effect of standardization would be to further enhance safety by improving the exchange of construction and operating experience among a number of reactors belonging to fleets of the same design. The World Nuclear Association's CORDEL (Cooperation in Reactor Design Evaluation and Licensing) Group has developed a concept for implementation of international standardization of reactor designs. It has defined a number of steps to be taken by industry. At the same time, possibilities offered by national and international regulatory mechanisms would have to be fully made use of, and some changes in regulatory frameworks might be necessary. Some steps especially towards greater cooperation of regulators have already been taken; however, much still remains to be done. The concept of deploying standardized reactor designs across a number of countries supposes an alignment and, if possible, harmonization of national safety standards; a streamlining of national licensing procedures, making them more efficient and predictable; and the willingness of national regulators to take into account licensing done in other countries. In the end, this should lead to a mutual acceptance of design approvals or, in a more distant future, even to a multinational design approval process. All in all, the concept

Selecting International Standards for Accrual-Based Accounting in the Public Sector

DEFF Research Database (Denmark)

Pontoppidan, Caroline Aggestam

2011-01-01

The article discusses the definition of a government business enterprise (GBE), as provided in the International Public Sector Accounting Standards (IPSAS), as a determinant for applying IPSAS or the International Financial Reporting Standards (IFRS) for a public sector entity. The work...... of the IPSASB is focused on the accounting and financial reporting needs of national, regional and local governments, and related governmental agencies, while the IFRS serves the private sector....

78 FR 40740 - Advisory Council on the Standards for Internal Control in the Federal Government

Science.gov (United States)

2013-07-08

... GOVERNMENT ACCOUNTABILITY OFFICE Advisory Council on the Standards for Internal Control in the... on the Green Book Advisory Council and the Standards for Internal Control in the Federal Government.... SUMMARY: The US Government Accountability Office (GAO) is preparing to revise the Standards for Internal...

Potassium Stable Isotopic Compositions Measured by High-Resolution MC-ICP-MS

Science.gov (United States)

Morgan, Leah E.; Lloyd, Nicholas S.; Ellam, Robert M.; Simon, Justin I.

2012-01-01

Potassium isotopic (K-41/K-39) compositions are notoriously difficult to measure. TIMS measurements are hindered by variable fractionation patterns throughout individual runs and too few isotopes to apply an internal spike method for instrumental mass fractionation corrections. Internal fractionation corrections via the K-40/K-39 ratio can provide precise values but assume identical K-40/K-39 ratios (e.g. 0.05% (1sigma) in [1]); this is appropriate in some cases (e.g. identifying excess K-41) but not others (e.g., determining mass fractionation effects and metrologically traceable isotopic abundances). SIMS analyses have yielded measurements with 0.25% precisions (1sigma) [2]. ICP-MS analyses are significantly affected by interferences from molecular species such as Ar-38H(+) and Ar-40H(+) and instrument mass bias. Single collector ICP-MS instruments in "cold plasma" mode have yielded uncertainties as low as 2% (1sigma, e.g. [3]). Although these precisions may be acceptable for some concentration determinations, they do not resolve isotopic variation in terrestrial materials. Here we present data from a series of measurements made on the Thermo Scientific NEPTUNE Plus multi-collector ICP-MS that demonstrate the ability to make K-41/K-39 ratio measurements with 0.07% precisions (1sigma). These data, collected on NIST K standards, indicate the potential for MC-ICP-MS measurements to look for K isotopic variations at the sub-permil level. The NEPTUNE Plus can sufficiently resolve 39K and 41K from the interfering 38ArH+ and 40ArH+ peaks in wet cold plasma and high-resolution mode. Measurements were made on small but flat, interference-free, plateaus (ca. 50 ppm by mass width for K-41). Although ICP-MS does not yield accurate K-41/K-39 values due to significant instrumental mass fractionation (ca. 6%), this bias can be sufficiently stable over the time required for several measurements so that relative K-41/K-39 values can be precisely determined via sample-standard

International standards for phytosanitary measures (ISPM), publication No. 15

CERN Multimedia

Tom Wegelius

2006-01-01

GUIDELINES FOR REGULATING WOOD PACKAGING MATERIAL IN INTERNATIONAL TRADE SCOPE This standard describes phytosanitary measures to reduce the risk of introduction and/or spread of quarantine pests associated with wood packaging material (including dunnage), made of coniferous and non-coniferous raw wood, in use in international trade. For more information, contact the Shipping Service (FI-LS-SH) at 79947. Table of guidelines

A manual for a Laboratory Information Management System (LIMS) for light stable isotopes

Science.gov (United States)

Coplen, Tyler B.

1998-01-01

The reliability and accuracy of isotopic data can be improved by utilizing database software to (i) store information about samples, (ii) store the results of mass spectrometric isotope-ratio analyses of samples, (iii) calculate analytical results using standardized algorithms stored in a database, (iv) normalize stable isotopic data to international scales using isotopic reference materials, and (v) generate multi-sheet paper templates for convenient sample loading of automated mass-spectrometer sample preparation manifolds. Such a database program is presented herein. Major benefits of this system include (i) an increase in laboratory efficiency, (ii) reduction in the use of paper, (iii) reduction in workload due to the elimination or reduction of retyping of data by laboratory personnel, and (iv) decreased errors in data reported to sample submitters. Such a database provides a complete record of when and how often laboratory reference materials have been analyzed and provides a record of what correction factors have been used through time. It provides an audit trail for stable isotope laboratories. Since the original publication of the manual for LIMS for Light Stable Isotopes, the isotopes 3 H, 3 He, and 14 C, and the chlorofluorocarbons (CFCs), CFC-11, CFC-12, and CFC-113, have been added to this program.

Isotope analysis (δ13C of pulpy whole apple juice

Directory of Open Access Journals (Sweden)

Ricardo Figueira

2011-09-01

Full Text Available The objectives of this study were to develop the method of isotope analysis to quantify the carbon of C3 photosynthetic cycle in pulpy whole apple juice and to measure the legal limits based on Brazilian legislation in order to identify the beverages that do not conform to the Ministry of Agriculture, Livestock and Food Supply (MAPA. This beverage was produced in a laboratory according to the Brazilian law. Pulpy juices adulterated by the addition of sugarcane were also produced. The isotope analyses measured the relative isotope enrichment of the juices, their pulpy fractions (internal standard and purified sugar. From those results, the quantity of C3 source was estimated by means of the isotope dilution equation. To determine the existence of adulteration in commercial juices, it was necessary to create a legal limit according to the Brazilian law. Three brands of commercial juices were analyzed. One was classified as adulterated. The legal limit enabled to clearly identify the juice that was not in conformity with the Brazilian law. The methodology developed proved efficient for quantifying the carbon of C3 origin in commercial pulpy apple juices.

Guidelines for drafting national and international seismic standards

International Nuclear Information System (INIS)

Podrouzek, J.

1989-01-01

The main principles of engineering reliability are discussed in relation to the formation of seismic standards. The basic recommendations of the International Association of Earthquake Engineering in the field of inspection and earthquake resistance evaluation of engineering structures and systems are characterized. Attention is also paid to efforts aimed at a unification of standards and regulations, based on the fact that quasistatic and response spectra methods are largely common to the standards amd regulations. However, as the potential of computer techniques increases, more complex computer programs appear and the amount of tenuous input data increases, and this can affect the quality of seismic inspections. (Z.M.). 5 figs., 1 ref

Manual of engineering drawing to British and international standards

CERN Document Server

Simmons, Colin H; Maguire, Dennis E

2004-01-01

The Manual of Engineering Drawing has long been recognised as the student and practising engineer's guide to producing engineering drawings that comply with ISO and British Standards. The information in this book is equally applicable to any CAD application or manual drawing. The second edition is fully in line with the requirements of the new British Standard BS8888: 2002, and will help engineers, lecturers and students with the transition to the new standards.BS8888 is fully based on the relevant ISO standards, so this book is also ideal for an international readership. The comprehen

Improving the efficiency of quantitative (1)H NMR: an innovative external standard-internal reference approach.

Science.gov (United States)

Huang, Yande; Su, Bao-Ning; Ye, Qingmei; Palaniswamy, Venkatapuram A; Bolgar, Mark S; Raglione, Thomas V

2014-01-01

The classical internal standard quantitative NMR (qNMR) method determines the purity of an analyte by the determination of a solution containing the analyte and a standard. Therefore, the standard must meet the requirements of chemical compatibility and lack of resonance interference with the analyte as well as a known purity. The identification of such a standard can be time consuming and must be repeated for each analyte. In contrast, the external standard qNMR method utilizes a standard with a known purity to calibrate the NMR instrument. The external standard and the analyte are measured separately, thereby eliminating the matter of chemical compatibility and resonance interference between the standard and the analyte. However, the instrumental factors, including the quality of NMR tubes, must be kept the same. Any deviations will compromise the accuracy of the results. An innovative qNMR method reported herein utilizes an internal reference substance along with an external standard to assume the role of the standard used in the traditional internal standard qNMR method. In this new method, the internal reference substance must only be chemically compatible and be free of resonance-interference with the analyte or external standard whereas the external standard must only be of a known purity. The exact purity or concentration of the internal reference substance is not required as long as the same quantity is added to the external standard and the analyte. The new method reduces the burden of searching for an appropriate standard for each analyte significantly. Therefore the efficiency of the qNMR purity assay increases while the precision of the internal standard method is retained. Copyright © 2013 Elsevier B.V. All rights reserved.

Kandungan Prinsip Konservatisme dalam Standar Akuntansi Keuangan Berbasis IFRS (International Financial Reporting Standard)

OpenAIRE

Ahmad Juanda

2012-01-01

Kandungan Prinsip Konservatisme DalamStandar Akuntansi Keuangan Berbasis IFRS(International Financial Reporting Standard)Ahmad JuandaStaf Pengajar Jurusan Akutansi, Fakultas Ekonomi dan BisnisUniversitas Muhammadiyah This study aims to reveal the content of the principle of conservatism contained in financial accounting standards (GAAP) results of the convergence of International Financial Reporting Standards (IFRS). The use of the principle of conservatism still...

A novel procedure for Rubidium separation and its isotope measurements on geological samples by MC-ICP-MS

Science.gov (United States)

Ma, J.; Zhang, Z.; Wei, G.; Zhang, L.

2017-12-01

A method including a novel column Rb separation procedure and high-precision Rb isotope measurement in geological materials by using multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) in standard-sample-bracketing (SSB) mode has been developed. Sr-Spec resin was employed, in which the distribution coefficients for Rb, K, Ba and Sr are different in nitric acid, to sequentially separate them from the matrix. The dissolved samples were loaded on the column in 3 M HNO3, the main matrix such as Al, Ca, Fe, Mg, Mn and Na were removed by rinsing with 4.5 mL HNO3, Rb and K were then sequentially eluted by 3 M HNO3 in different volumes. After that, Ba was eluted by 8 M HNO3, and Sr was finally eluted by Milli-Q water. This enable us to collect the pure Rb, K, Ba and Sr one by one with recovery close to 100% for their isotopic compositions measurement on MC-ICP-MS. We here focus on Rb isotope measurement. The measurement using MC-ICP-MS yielded an internal precision for δ87Rb of external precision was generally better than ± 0.06‰ (2SD) based on the long-term results of the Rb standard solutions NIST SRM 984. A series of geological rock standards, were analyzed using this method, and the results indicate significant Rb isotope differences in different geologic materials. This will provide a powerful tool to investigate Rb isotope fractionation during geological processes.Based on this method, Rb isotope compositions from a basaltic weathering profile were carried out. The data show the lighter Rb (85Rb) isotope is preferentially leached from the weathering profile and remains heavy Rb isotope (87Rb) in the weathered residues during the incipient weathering stage. From the moderate to advanced weathering stage, the significant variations of Rb isotope were observed and multiple factors, such as leaching, adsorption, desorption, and precipitation, should play important role in fractionating Rb isotope.

Uses of stable isotopes

International Nuclear Information System (INIS)

Axente, Damian

1998-01-01

The most important fields of stable isotope use with examples are presented. These are: 1. Isotope dilution analysis: trace analysis, measurements of volumes and masses; 2. Stable isotopes as tracers: transport phenomena, environmental studies, agricultural research, authentication of products and objects, archaeometry, studies of reaction mechanisms, structure and function determination of complex biological entities, studies of metabolism, breath test for diagnostic; 3. Isotope equilibrium effects: measurement of equilibrium effects, investigation of equilibrium conditions, mechanism of drug action, study of natural processes, water cycle, temperature measurements; 4. Stable isotope for advanced nuclear reactors: uranium nitride with 15 N as nuclear fuel, 157 Gd for reactor control. In spite of some difficulties of stable isotope use, particularly related to the analytical techniques, which are slow and expensive, the number of papers reporting on this subject is steadily growing as well as the number of scientific meetings organized by International Isotope Section and IAEA, Gordon Conferences, and regional meeting in Germany, France, etc. Stable isotope application development on large scale is determined by improving their production technologies as well as those of labeled compound and the analytical techniques. (author)

25 CFR 542.11 - What are the minimum internal control standards for pari-mutuel wagering?

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What are the minimum internal control standards for pari... INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.11 What are the minimum internal control... documentation and/or procedures that provide at least the level of control described by the standards in this...

Review international standards for grid connected photovoltaic systems in Malaysia

International Nuclear Information System (INIS)

Mekhilef, S.; Rahim, N.A.

2006-01-01

Grid connected PV is being applied on variety application including large centralised stations, commercial building and individual houses. There is a need for specific standard to address distinctive new issue created by grid connected PV power system. Internationally many countries are attempting to develop standards for building integration, Dc side issues and grid connection issues. This paper surveys the current development state of the major countries standards in this area, comparing and contrasting, standards and guideline under development, also addressing the need of standards for grid connected in Malaysia

International accounting standards and their effect on mergers and acquisitions

Directory of Open Access Journals (Sweden)

Blanca I. Vega Castro

2007-09-01

Full Text Available The main objective of this paper is to investigate whether the international accounting harmonization has favored the globalization process. This investigation examined the relationship between international accounting standards and the international merger and acquisition activities in Argentina, Brazil, Chile, México, Peru and Venezuela from 1995 to 2004. This research tested four hypotheses and used analytics such as panel data analysis, correlation, nonparametric tests and logistic regression.

Modelling of stable isotope fractionation by methane oxidation and diffusion in landfill cover soils

International Nuclear Information System (INIS)

Mahieu, Koenraad; De Visscher, Alex; Vanrolleghem, Peter A.; Van Cleemput, Oswald

2008-01-01

A technique to measure biological methane oxidation in landfill cover soils that is gaining increased interest is the measurement of stable isotope fractionation in the methane. Usually to quantify methane oxidation, only fractionation by oxidation is taken into account. Recently it was shown that neglecting the isotope fractionation by diffusion results in underestimation of the methane oxidation. In this study a simulation model was developed that describes gas transport and methane oxidation in landfill cover soils. The model distinguishes between 12 CH 4 , 13 CH 4 , and 12 CH 3 D explicitly, and includes isotope fractionation by diffusion and oxidation. To evaluate the model, the simulations were compared with column experiments from previous studies. The predicted concentration profiles and isotopic profiles match the measured ones very well, with a root mean square deviation (RMSD) of 1.7 vol% in the concentration and a RMSD of 0.8 per mille in the δ 13 C value, with δ 13 C the relative 13 C abundance as compared to an international standard. Overall, the comparison shows that a model-based isotope approach for the determination of methane oxidation efficiencies is feasible and superior to existing isotope methods

[From manual workshop to international standard maker: exploration on production standard of acupuncture needle by Chengjiang acupuncture school].

Science.gov (United States)

Cheng, Jie; Cao, Yang; Xia, Youbing

2015-02-01

ABSTRACT The exploration course on production standard of acupuncture needle by Chengjiang acupuncture school is reviewed in this paper. After new China was established, acupuncture needle standard was unified by Mr. CHENG Dan-an, which guided Suzhou Hua Erfang (predecessor of Suzhou Medical Supplies Factory) to make the quality standards and testing methods of acupuncture needle and improved the production process to make the modern acupuncture needle. Based on this, Suzhou Medical Supplies Factory followed the time development pace, ac tively introduced new technology, carried out technological innovation, and constantly improved the level of production technology, as a result, it gradually developed into one of the world's largest acupuncture needle production suppliers. Meanwhile, after establishing China's first national standard on acupuncture needle (GB 2024-1980), the Suzhou Medical Supplies Factory took the lead to draft "ISO) 17218:2014 the disposable use asepsis acupuncture needle", which was officially published as an international standard. The Suzhou Medical Supplies Factory developed from a manual workshop to an international standard maker.

How Do Firms Comply with International Sustainability Standards?

DEFF Research Database (Denmark)

Vigneau, Laurence; Humphreys, Michael; Moon, Jeremy

2015-01-01

This paper addresses the issue of the influence of global governance institutions, particularly international sustainability standards, on a firm’s intra-organizational practices. More precisely, we provide an exploratory empirical view of the impact of the Global Reporting Initiative (GRI......, the relationships between subsidiaries, the temporal dimension of CSR management and the interpretation of CSR performance. We also highlight the need to look at the relationship dynamics (or lack of) between standards. Finally, we illustrate and discuss the role of reporting and its influence on management...

Relationship between internal medicine program board examination pass rates, accreditation standards, and program size.

Science.gov (United States)

Falcone, John L; Gonzalo, Jed D

2014-01-19

To determine Internal Medicine residency program compliance with the Accreditation Council for Graduate Medical Education 80% pass-rate standard and the correlation between residency program size and performance on the American Board of Internal Medicine Certifying Examination. Using a cross-sectional study design from 2010-2012 American Board of Internal Medicine Certifying Examination data of all Internal Medicine residency pro-grams, comparisons were made between program pass rates to the Accreditation Council for Graduate Medical Education pass-rate standard. To assess the correlation between program size and performance, a Spearman's rho was calculated. To evaluate program size and its relationship to the pass-rate standard, receiver operative characteristic curves were calculated. Of 372 Internal Medicine residency programs, 276 programs (74%) achieved a pass rate of =80%, surpassing the Accreditation Council for Graduate Medical Education minimum standard. A weak correlation was found between residency program size and pass rate for the three-year period (p=0.19, pInternal Medicine residency programs complied with Accreditation Council for Graduate Medical Education pass-rate standards, a quarter of the programs failed to meet this requirement. Program size is positively but weakly associated with American Board of Internal Medicine Certifying Examination performance, suggesting other unidentified variables significantly contribute to program performance.

The role of food standards on international trade: assessing the Brazilian beef chain

Directory of Open Access Journals (Sweden)

Luciana Marques Vieira

2006-01-01

Full Text Available The purpose of this paper is to identify how Brazilian beef managers have responded to a rapid expansion and intensification of standards for beef exports. This issue relates to how some Brazilian beef exporters are strategically repositioning themselves in the supply chains. The literature of this study reviews global chain governance and international standards. The method uses case studies consisting of six medium and large scale beef exporters who export fresh beef to the European Union. The main findings describe the kinds of governance that stimulate upgrading and transferral of the best practices and, consequently, full compliance with mandatory standards. This study suggests that standards do matter for companies trying to increase international competitiveness. These results contribute an understanding of the Brazilian beef chain, and also of other supply chains coping with demanding and changing international markets. Managerial implications show the challengesfacing Brazilian beef exporters in their efforts to sustain exports to the European Union and how they are using chain governance to improve their compliance with international standards and increase competitiveness.

FY 2000 Project of developing international standards for supporting new industries. Comprehensive study for promotion of the international standardization; 2000 nendo shinki sangyo shiengata kokusai hyojun kaihatsu jigyo seika hokokusho. Kokusai hyojunka suishin ni kakawaru hokatsuteki chosa kenkyu

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

This project studies the schemes for the international standardization, trends of the international standardization by the international standardization organizations and related organizations, and activities for the international standardization by the enterprises in the advanced countries, among others, in order to promote the international standardization for the 8 research and development themes. These themes are SMIL (synchronized multimedia integration language) tag standard of the three-dimensional image data, based on MXL; systems for detecting gene recombination products; methods for testing mileage of gas-fueled automobiles; measurement of multi-colors; testing/evaluation methods for highly coherent lasers; methods of evaluating optical performance of microlenses for optical information processing; recycled CFRPs; and devices for measuring marine environments. The study results indicate that progress of the development of the international standardization of the advanced technologies can be followed by investigating the characteristics of the ISO publications; ISO is studying the business plans being developed by each TC, in order to improve market adaptability of the international standards; and the European countries add conditions for standardization when the research and development themes are contracted. (NEDO)

Adaptations of International Standards on Educational Leadership Preparation in Egypt

Science.gov (United States)

Purinton, Ted; Khalil, Dalia

2016-01-01

This paper is a case study of one leadership preparation program, utilizing US school leadership standards and practices, offered in Egypt. This case study illuminates how cultural and policy distinctions impact differing necessities of educational leadership, and how those necessities conflict or concur with the international standards and…

Trends in the use of stable isotopes in biochemistry and pharmacology

International Nuclear Information System (INIS)

Matwiyoff, N.A.; Walker, T.E.

1977-01-01

Recent trends in the use of the stable isotopes 13 C, 15 N and 18 O in biochemistry and pharmacology are reviewed with emphasis on the studies that have employed nuclear magnetic resonance (nmr) spectroscopy and mass spectrometry as analytical techniques. Pharmacological studies with drugs and other compounds labelled with stable isotopes have developed in parallel with the rapid progress in the enhancement of sensitivity and selectivity of gas chromatography - mass spectrometric analyses, and have been directed largely to an evaluation of pharmako-kinetics and drug metabolic pathways. In these studies, illustrated with selected samples, isotopically labelled compounds have been used to advantage as internal standards for the mass spectrometric analyses and as in vivo tracers for metabolites. In the broader discipline of biochemistry, stable isotopes and isotopically labelled compounds have been used increasingly in conjuction with both nmr spectroscopy and mass spectrometry in tracer and structural studies. The more recent trends in the use of stable isotopes in these biochemical studies are discussed in the context of the improvements in analytical techniques. Specific examples will be drawn from investigations of the biosynthesis of natural products by micro-organisms; the protein, fat and carbohydrate fluxes in humans; and the structure and function of enzymes, membranes and other macro-molecular assemblages. The potential for the future development of stable isotopes in biochemistry and pharmacology are considered briefly, together with some of the problems that must be solved if their considerable potential is to be realized. (author)

Quantifying mercury isotope dynamics in captive Pacific bluefin tuna (Thunnus orientalis

Directory of Open Access Journals (Sweden)

Sae Yun Kwon

2016-02-01

Full Text Available Abstract Analyses of mercury (Hg isotope ratios in fish tissues are used increasingly to infer sources and biogeochemical processes of Hg in natural aquatic ecosystems. Controlled experiments that can couple internal Hg isotope behavior with traditional isotope tracers (δ13C, δ15N can improve the applicability of Hg isotopes as natural ecological tracers. In this study, we investigated changes in Hg isotope ratios (δ202Hg, Δ199Hg during bioaccumulation of natural diets in the pelagic Pacific bluefin tuna (Thunnus orientalis; PBFT. Juvenile PBFT were fed a mixture of natural prey and a dietary supplement (60% Loligo opalescens, 31% Sardinops sagax, 9% gel supplement in captivity for 2914 days, and white muscle tissues were analyzed for Hg isotope ratios and compared to time in captivity and internal turnover of δ13C and δ15N. PBFT muscle tissues equilibrated to Hg isotope ratios of the dietary mixture within ∼700 days, after which we observed a cessation in further shifts in Δ199Hg, and small but significant negative δ202Hg shifts from the dietary mixture. The internal behavior of Δ199Hg is consistent with previous fish studies, which showed an absence of Δ199Hg fractionation during Hg bioaccumulation. The negative δ202Hg shifts can be attributed to either preferential excretion of Hg with higher δ202Hg values or individual variability in captive PBFT feeding preferences and/or consumption rates. The overall internal behavior of Hg isotopes is similar to that described for δ13C and δ15N, though observed Hg turnover was slower compared to carbon and nitrogen. This improved understanding of internal dynamics of Hg isotopes in relation to δ13C and δ15N enhances the applicability of Hg isotope ratios in fish tissues for tracing Hg sources in natural ecosystems.

Language standardization in sociolinguistics and international business: Theory and practice across the table

DEFF Research Database (Denmark)

Linn, Andrew; Sanden, Guro Refsum; Piekkari, Rebecca

2018-01-01

Haugen to explain the history of modern Norwegian. The table is then turned and a model from international business by Piekkari, Welch and Welch is used to illuminate recent Norwegian language planning. It is found that the Grundfos case works well with the Haugen model, and the international business......This chapter addresses the issue of language standardization from two perspectives, bringing together a theoretical perspective offered by the discipline of sociolinguistics with a practical example from international business. We introduce the broad concept of standardization and embed the study...... of language standardization in the wider discussion of standards as a means of control across society. We analyze the language policy and practice of the Danish multinational, Grundfos, and use it as a “sociolinguistic laboratory” to “test” the theory of language standardization initially elaborated by Einar...

International Banking Standards, Private Law, and the European Union

DEFF Research Database (Denmark)

Wouters, Jan; Odermatt, Jed

2016-01-01

This chapter seeks to provide an insight into the dynamics that take place between the EU and international standard-setting bodies, by first examining some of the features of global financial regulation which make it a unique area of global governance, then by investigating the wide variety of n...... the crisis. These reforms have been highly influenced by non-binding commitments made in informal bodies at the international level....

Standard methods for sampling freshwater fishes: opportunities for international collaboration

OpenAIRE

Bonar, Scott A.; Mercado-Silva, Norman; Hubert, Wayne A.; Beard, T. Douglas; Dave, Göran; Kubečka, Jan; Graeb, Brian D.S.; Lester, Nigel P.; Porath, Mark; Winfield, Ian J.

2017-01-01

With publication of Standard Methods for Sampling North American Freshwater Fishes in 2009, the American Fisheries Society (AFS) recommended standard procedures for North America. To explore interest in standardizing at intercontinental scales, a symposium attended by international specialists in freshwater fish sampling was convened at the 145th Annual AFS Meeting in Portland, Oregon, in August 2015. Participants represented all continents except Australia and Antarctica and were employed by...

INTERNATIONAL STANDARDS FOR FINANCIAL REPORTING: HARMONIZATION IN MACEDONIA

Directory of Open Access Journals (Sweden)

Sasho Kozuharov

2015-12-01

Full Text Available A continuous flow of reliable, relevant and financially important information is necessary for making economically justified and strategic investment decisions. Economic globalization has contributed to the need of creating a unified language for communication, a single set of international financial reporting standards with the sole purpose of enhancing transparency for investors and reducing the cost of capital. Harmonization of financial reporting provides more efficient use of global resources, easier consolidation of multinational companies foreign subsidiaries, alleviation of accounting staff mobility and reducing of audit costs. The research is based on the benefits that the national economy can gain if the international financial reporting standards are successfully implemented. Special attention in the paper is devoted to the factors that determine the harmonization of financial reporting. The analysis of the results show the managers' perception of financial reporting, and emphasize the effects of the implementation of IFRS in Republic of Macedonia.

CSNI International standard problems (ISP). Brief descriptions (1975-1999)

International Nuclear Information System (INIS)

2000-03-01

Over the last twenty-five years the NEA Committee on the Safety of Nuclear Installations (CSNI) has sponsored a considerable number of international activities to promote the exchange of experience between its Member countries in the use of nuclear safety codes and testing materials. A primary goal of these activities is to increase confidence in the validity and accuracy of analytical tools or testing procedures which are needed in warranting the safety of nuclear installations, and to demonstrate the competence of involved institutions. International Standard Problems (ISPs) exercises are comparative exercises in which predictions or recalculations of a given physical problem with different best-estimate computer code are compared with each other and above all with the results of a carefully specified experimental study. ISP exercises are performed as 'open' or 'blind' problems. In an open Standard Problem exercise the results of the experiment are available to the participants before performing the calculations, while in a blind Standard Problem exercise the experimental results are locked until the calculation results are made available for comparison. The CSNI-promoted ISP activity started in the early 70's and is still underway. Parallel to other national and international programs the CSNI has sponsored over more than 25 years forty-seven International Standard Problem exercises. This program has been focused mainly on the applicability of large thermal-hydraulic code systems simulating the behaviour of nuclear coolant and containment systems, fuel behaviour under accident conditions, hydrogen distribution, core-concrete interactions and fission product release and transport. One ISP exercise was organised in connection with a seismic ultimate dynamic response test. ISP exercises have proven to be very valuable to participating countries. They have been fruitful to identify code application problems and to amplify the contacts between the experimental and

New tendencies in isotopic analysis of pesticide residues from wines by mass spectrometry in concordance with the European standards

International Nuclear Information System (INIS)

Costinel, Diana; Lazar, Roxana Elena; Vremera, Raluca; Irimescu, Rodica; Saros-Rogobete, Gili

2006-01-01

Multi-isotope analysis, the determination of isotope ratios by mass spectrometry or magnetic resonance spectroscopy, becomes increasingly used in the food industry and by national food control laboratories as a method of authenticating both raw materials and finished products. These highly sophisticated techniques are capable of determining the botanical and geographical origin of a wide variety of foodstuffs, thus providing a means of detecting product adulteration and controlling mislabelling practices which are virtually impossible to circumvent. The European Union has officially adopted the used of isotope analysis as a means of controlling sugar addition in wines. Its successful implementation in the wine-producing Member States has considerably reduced the financial losses which the Community had incurred due to over - capitalisation. Coupling mass spectrometer with gas chromatograph is used for quantitative and qualitative analysis of traces of pesticides from food. The presence of pesticides in foods is harmful for the nervous system, the cardiovascular apparatus and decreases the immunity of human body. In addition, ensuring the foods quality and safety is a requirement, which must be fulfilled for the integration in EU. The subject of this paper is the presentation of the tests results of the isotopic analysis for pesticide residues in wines, in concordance with European Standard. (authors)

On a Lie-isotopic theory of gravity

International Nuclear Information System (INIS)

Gasperini, M.

1984-01-01

Starting from the isotopic lifting of the Poincare algebra, a Lie-isotopic theory of gravity is formulated, its physical interpretation is given in terms of a generalized principle of equivalence, and it is shown that a local Lorentz-isotopic symmetry motivates the introduction of a generalized metric-affine geometrical structure. Finally, possible applications of a Lie-isotopic theory to the problem of unifying gravity with internal symmetries, in four and more than four dimensions, are discussed

A Metadata Standard for Hydroinformatic Data Conforming to International Standards

Science.gov (United States)

Notay, Vikram; Carstens, Georg; Lehfeldt, Rainer

2017-04-01

The affordable availability of computing power and digital storage has been a boon for the scientific community. The hydroinformatics community has also benefitted from the so-called digital revolution, which has enabled the tackling of more and more complex physical phenomena using hydroinformatic models, instruments, sensors, etc. With models getting more and more complex, computational domains getting larger and the resolution of computational grids and measurement data getting finer, a large amount of data is generated and consumed in any hydroinformatics related project. The ubiquitous availability of internet also contributes to this phenomenon with data being collected through sensor networks connected to telecommunications networks and the internet long before the term Internet of Things existed. Although generally good, this exponential increase in the number of available datasets gives rise to the need to describe this data in a standardised way to not only be able to get a quick overview about the data but to also facilitate interoperability of data from different sources. The Federal Waterways Engineering and Research Institute (BAW) is a federal authority of the German Federal Ministry of Transport and Digital Infrastructure. BAW acts as a consultant for the safe and efficient operation of the German waterways. As part of its consultation role, BAW operates a number of physical and numerical models for sections of inland and marine waterways. In order to uniformly describe the data produced and consumed by these models throughout BAW and to ensure interoperability with other federal and state institutes on the one hand and with EU countries on the other, a metadata profile for hydroinformatic data has been developed at BAW. The metadata profile is composed in its entirety using the ISO 19115 international standard for metadata related to geographic information. Due to the widespread use of the ISO 19115 standard in the existing geodata infrastructure

Double isotopic method using dansyl chloride for the determination of GABA in rat C6 astrocytoma cell cultures

Energy Technology Data Exchange (ETDEWEB)

Kohl, R.L.; Quay, W.B.; Perez-Polo, J.R.

1986-01-01

Methods are described for the quantitative measurement of GABA in culture. The method can be adapted to any amino acid or dansyl-chloride-reactive species. The sensitivity and selectivity of the procedure result from the double isotopic design in which (/sup 14/C)-labeled internal standard was added to the samples before reaction with (3M)-labeled dansyl chloride. Values obtained by ion-exchange amino acid analysis of cultures agree closely with the values obtained by the double isotopic method. This method is sensitive enough to measure GABA intracellularly and the condition medium.

Isotopic ratio measurement using a double focusing magnetic sector mass analyser with an inductively coupled plasma as an ion source

International Nuclear Information System (INIS)

Walder, A.J.; Freedman, P.A.

1992-01-01

An inductively coupled plasma source was coupled to a magnetic sector mass analyser equipped with seven Faraday detectors. An electrostatic filter located between the plasma source and the magnetic sector was used to create a double focusing system. Isotopic ratio measurements of uranium and lead standards revealed levels of internal and external precision comparable to those obtained using thermal inonization mass spectrometry. An external precision of 0.014% was obtained from the 235 U: 238 U measurement of six samples of a National Bureau of Standards (NBS) Standard Reference Material (SRM) U-500, while an RSD of 0.022% was obtained from the 206 Pb: 204 Pb measurement of six samples of NBS SRM Pb-981. Measured isotopic ratios deviated from the NBS value by approximately 0.9% per atomic mass unit. This deviation approximates to a linear function of mass bias and can therefore be corrected for by the analysis of standards. The analysis of NBS SRM Sr-987 revealed superior levels of internal and external precision. The normalization of the 87 Sr: 86 Sr ratio to the 86 Sr: 88 Sr ratio reduced the RSD to approximately 0.008%. The measured ratio was within 0.01% of the NBS value and the day-to-day reproducibility was consistent within one standard deviation. (author)

INTERNATIONAL ACCOUNTING STANDARDS AND THEIR INFLUENCE ON THE MANAGEMENT OF A COMPANY.

Directory of Open Access Journals (Sweden)

ANA - MARIA MĂLĂESCU

2015-03-01

Full Text Available The accounting standardization process is in progress at international and regional level, more and more countries have reached the same conclusion of enforcing high quality accounting standards like IAS / IFRS. There are various reasons for Romania adopting the international accounting referential most of them subordinated to its central aim, respectively EU accession. In our country the accounting system is subordinated to the taxation system, financing still comes prevalent from banks and very few Romanian companies are listed on foreign capital markets. Romania is an ex-communist emergent country in wich changes in the economic and political environment merely started only after the end of the communist regime in the early 1990s. Many European companies already observed that by enforcing IFRS standards they have access to international capital markets, they could reduce expenses and unroll international transactions easier. It is improbable that a financial reporting, which is not easy understood by all its users, would offer new business opportunities or additional capital.Therefore, a significant number of companies, either voluntarily enforce IFRS standards, or they are pledged by the government to do this.

International financial reporting standards and foreign ownership in ...

African Journals Online (AJOL)

Previous literature suggests that the adoption of International Financial Reporting Standards (IFRS) can facilitate cross-border capital flows, as it results in an increase in market liquidity and comparability benefits. Using foreign ownership levels in South African listed companies during the period 2003 to 2007, we test ...

Comparison between IRMS and CRDS methods in the determination of isotopic ratios 2H/1H and 18O/16O in water

International Nuclear Information System (INIS)

Santos, T. H. R.; Zucchi, M. R.; Lemaire, T.; Azevedo, A. E. G.

2013-01-01

Traditionally, the method used for measuring the isotope ratios is the Isotope Ratio Mass Spectrometers (IRMS). A new method has been used to determine the isotopic abundances, the Cavity Ring-Down Spectroscopy (CRDS). It consists of a technique of direct absorption, of high sensitivity, which is based on measuring the absorption ratio, as a function of time, of the light confined in a high finesse optical cavity, instead of the magnitude of light beam absorption. The values of 18 O/ 16 O and D/H ratios are determined with respect to international standards VSMOW, GISP and SLAP from the International Atomic Energy Agency (IAEA). In this work, the IRMS and CRDS techniques are compared, verifying that the CRDS technique is promising and has some advantages compared to IRMS. It uses a smaller amount of sample, the isotope measurements are made simultaneously from the steam, reducing the analysis time. It also shows good reproducibility and accuracy, and it does not require a preliminary sample preparation.

Determinants of Effective Information Transfer in International Regulatory Standards Adoption

Science.gov (United States)

Popescu, Denisa

2010-01-01

The role of international regulatory standards within the current global environment has become of the most importance. The age of the global system and free market capitalism carried us into the unprecedented age of regulations, and standard setting. Regulations are now becoming the emerging mode of global governance. This study focuses on…

78 FR 22263 - Advisory Council on the Standards for Internal Control in the Federal Government; Meeting

Science.gov (United States)

2013-04-15

... GOVERNMENT ACCOUNTABILITY OFFICE Advisory Council on the Standards for Internal Control in the... Standards for Internal Control in the Federal Government; Notice of Meeting. SUMMARY: The US Government Accountability Office (GAO) is initiating efforts to revise the Standards for Internal Control in the Federal...

Bismuth as a general internal standard for lead in atomic absorption spectrometry

International Nuclear Information System (INIS)

Bechlin, Marcos A.; Fortunato, Felipe M.; Ferreira, Edilene C.; Neto, José A. Gomes; Nóbrega, Joaquim A.; Donati, George L.; Jones, Bradley T.

2014-01-01

Highlights: • Single internal standard is commonly proposed for definite application in AAS. • Internal standard for general use in AAS techniques is original. • Bi showed efficiency as internal standard for Pb determinations by FAAS and GFAAS. • Assorted samples were analyzed and accurate results were found. - Abstract: Bismuth was evaluated as internal standard for Pb determination by line source flame atomic absorption spectrometry (LS FAAS), high-resolution continuum source flame atomic absorption spectrometry (HR-CS FAAS) and line source graphite furnace atomic absorption spectrometry (LS GFAAS). Analysis of samples containing different matrices indicated close relationship between Pb and Bi absorbances. Correlation coefficients of calibration curves built up by plotting A Pb /A Bi versus Pb concentration were higher than 0.9953 (FAAS) and higher than 0.9993 (GFAAS). Recoveries of Pb improved from 52–118% (without IS) to 97–109% (IS, LS FAAS); 74–231% (without IS) to 96–109% (IS, HR-CS FAAS); and 36–125% (without IS) to 96–110% (IS, LS GFAAS). The relative standard deviations (n = 12) were reduced from 0.6–9.2% (without IS) to 0.3–4.3% (IS, LS FAAS); 0.7–7.7% (without IS) to 0.1–4.0% (IS, HR-CS FAAS); and 2.1–13% (without IS) to 0.4–5.9% (IS, LS GFAAS)

[Determination of endogenous agmatine in rat plasma by isotope dilution-gas chromatography-mass spectrometry].

Science.gov (United States)

Qiu, Zhongli; Lin, Ying; Xiong, Zhili; Xie, Jianwei

2014-07-01

A method for the determination of endogenous agmatine in rat plasma was developed by isotope dilution-gas chromatography-negative chemical ionization mass spectrometry (GC-NCI/MS). The plasma samples were analyzed after protein precipitation, evaporation, derivatization by hexafluoroacetone (HFAA), and clean-up on a Florisil SPE column. The GC-MS analysis utilized stable isotope d8-agmatine as internal standard. The samples after treatme were tested by negative chemical ionization with selected ion monitoring (SIM) which was set at m/z 492 (molecular ion of agmatine) and m/z 500 (molecular ion of internal standard). The limit of detection (LOD) of agmatine standard solution was 0.005 7 ng/mL. The calibration curve of the agmatine spiked in rat plasma showed a good linear relationship at the range of 1.14-57.0 ng/mL (r = 0.997). The recoveries of agmatine spiked in rat plasma ranged from 92.3% to 109.8%. Inter-day and intra-day precisions were less than 15%. The average concentration level of agmatine in rat plasma was (22 +/- 9) ng/mL, and there was no significant difference between male and female SD rats (p > 0.05). The method is high sensitive and specific, and can be used for the determination of endogenous agmatine in plasma. It provides a strong support for the subsequent research of agmatine.

Isotopically controlled semiconductors

Energy Technology Data Exchange (ETDEWEB)

Haller, Eugene E.

2006-06-19

The following article is an edited transcript based on the Turnbull Lecture given by Eugene E. Haller at the 2005 Materials Research Society Fall Meeting in Boston on November 29, 2005. The David Turnbull Lectureship is awarded to recognize the career of a scientist who has made outstanding contributions to understanding materials phenomena and properties through research, writing, and lecturing, as exemplified by the life work of David Turnbull. Haller was named the 2005 David Turnbull Lecturer for his 'pioneering achievements and leadership in establishing the field of isotopically engineered semiconductors; for outstanding contributions to materials growth, doping and diffusion; and for excellence in lecturing, writing, and fostering international collaborations'. The scientific interest, increased availability, and technological promise of highly enriched isotopes have led to a sharp rise in the number of experimental and theoretical studies with isotopically controlled semiconductor crystals. This article reviews results obtained with isotopically controlled semiconductor bulk and thin-film heterostructures. Isotopic composition affects several properties such as phonon energies, band structure, and lattice constant in subtle, but, for their physical understanding, significant ways. Large isotope-related effects are observed for thermal conductivity in local vibrational modes of impurities and after neutron transmutation doping. Spectacularly sharp photoluminescence lines have been observed in ultrapure, isotopically enriched silicon crystals. Isotope multilayer structures are especially well suited for simultaneous self- and dopant-diffusion studies. The absence of any chemical, mechanical, or electrical driving forces makes possible the study of an ideal random-walk problem. Isotopically controlled semiconductors may find applications in quantum computing, nanoscience, and spintronics.

Quantification of endogenous metabolites by the postcolumn infused-internal standard method combined with matrix normalization factor in liquid chromatography-electrospray ionization tandem mass spectrometry.

Science.gov (United States)

Liao, Hsiao-Wei; Chen, Guan-Yuan; Wu, Ming-Shiang; Liao, Wei-Chih; Tsai, I-Lin; Kuo, Ching-Hua

2015-01-02

Quantification of endogenous metabolites has enabled the discovery of biomarkers for diagnosis and provided for an understanding of disease etiology. The standard addition and stable isotope labeled-internal standard (SIL-IS) methods are currently the most widely used approaches to quantifying endogenous metabolites, but both have some limitations for clinical measurement. In this study, we developed a new approach for endogenous metabolite quantification by the postcolumn infused-internal standard (PCI-IS) method combined with the matrix normalization factor (MNF) method. MNF was used to correct the difference in MEs between standard solution and biofluids, and PCI-IS additionally tailored the correction of the MEs for individual samples. Androstenedione and testosterone were selected as test articles to verify this new approach to quantifying metabolites in plasma. The repeatability (n=4 runs) and intermediate precision (n=3 days) in terms of the peak area of androstenedione and testosterone at all tested concentrations were all less than 11% relative standard deviation (RSD). The accuracy test revealed that the recoveries were between 95.72% and 113.46%. The concentrations of androstenedione and testosterone in fifty plasma samples obtained from healthy volunteers were quantified by the PCI-IS combined with the MNF method, and the quantification results were compared with the results of the SIL-IS method. The Pearson correlation test showed that the correlation coefficient was 0.98 for both androstenedione and testosterone. We demonstrated that the PCI-IS combined with the MNF method is an effective and accurate method for quantifying endogenous metabolites. Copyright © 2014 Elsevier B.V. All rights reserved.

International standards for optical wireless communications: state-of-the-art and future directions

Science.gov (United States)

Marciniak, Marian

2017-10-01

As the number of active OWC installations is growing fast, the standards for compatibility of co-existing neighbouring systems are being developed. The paper addresses the Laser Safety (IEC standards), ITU-T Study Group 15 standards (G.640 Co-location longitudinally compatible interfaces for free space optical systems), ITU-Radiocommunication Sector standards (P.1817-1 Propagation data required for the design of terrestrial free-space optical links), and the IEEE Work in Progress - standardization activity on Visible Light Communications. International standards of FSO communications have been reviewed and discussed. ITU, IEC, and IEEE International standards for Free-Space Optical links have been reviewed. The system reliability and availability as well as security issues will be addressed as well in the talk.

ISO 639-1 and ISO 639-2: International Standards for Language Codes. ISO 15924: International Standard for Names of Scripts.

Science.gov (United States)

Byrum, John D.

This paper describes two international standards for the representation of the names of languages. The first (ISO 639-1), published in 1988, provides two-letter codes for 136 languages and was produced primarily to meet terminological needs. The second (ISO 639-2) appeared in late 1998 and includes three-letter codes for 460 languages. This list…

Quantitative Isotope-Dilution High-Resolution-Mass-Spectrometry Analysis of Multiple Intracellular Metabolites in Clostridium autoethanogenum with Uniformly 13C-Labeled Standards Derived from Spirulina.

Science.gov (United States)

Schatschneider, Sarah; Abdelrazig, Salah; Safo, Laudina; Henstra, Anne M; Millat, Thomas; Kim, Dong-Hyun; Winzer, Klaus; Minton, Nigel P; Barrett, David A

2018-04-03

We have investigated the applicability of commercially available lyophilized spirulina ( Arthrospira platensis), a microorganism uniformly labeled with 13 C, as a readily accessible source of multiple 13 C-labeled metabolites suitable as internal standards for the quantitative determination of intracellular bacterial metabolites. Metabolites of interest were analyzed by hydrophilic-interaction liquid chromatography coupled with high-resolution mass spectrometry. Multiple internal standards obtained from uniformly (U)- 13 C-labeled extracts from spirulina were used to enable isotope-dilution mass spectrometry (IDMS) in the identification and quantification of intracellular metabolites. Extraction of the intracellular metabolites of Clostridium autoethanogenum using 2:1:1 chloroform/methanol/water was found to be the optimal method in comparison with freeze-thaw, homogenization, and sonication methods. The limits of quantification were ≤1 μM with excellent linearity for all of the calibration curves ( R 2 ≥ 0.99) for 74 metabolites. The precision and accuracy were found to be within relative standard deviations (RSDs) of 15% for 49 of the metabolites and within RSDs of 20% for all of the metabolites. The method was applied to study the effects of feeding different levels of carbon monoxide (as a carbon source) on the central metabolism and Wood-Ljungdahl pathway of C. autoethanogenum grown in continuous culture over 35 days. Using LC-IDMS with U- 13 C spirulina allowed the successful quantification of 52 metabolites in the samples, including amino acids, carboxylic acids, sugar phosphates, purines, and pyrimidines. The method provided absolute quantitative data on intracellular metabolites that was suitable for computational modeling to understand and optimize the C. autoethanogenum metabolic pathways active in gas fermentation.

Beneficial uses and production of isotopes

International Nuclear Information System (INIS)

2000-01-01

Radioactive and stable isotopes are widely used in many sectors including medicine, industry and research. Practically all countries in the world are using isotopes in one way or another. In many cases, isotopes have no substitute and in most of their applications they are more effective and cheaper than alternative techniques or processes. The production of isotopes is less widespread, but more than fifty countries have isotope production or separation facilities operated for domestic supply, and sometimes for international markets. In spite of the importance of isotopes in economic and social terms, comprehensive statistical data on volumes or values of isotope production and uses are not readily available. This lack of information led the NEA to include the topic in its programme of work. The study carried out by the NEA, in co-operation with the International Atomic Energy Agency (IAEA), aimed at collecting and analysing information on various aspects of isotope production and uses in order to highlight key issues and provide findings and recommendations of relevance, in particular, for governmental bodies involved. This report provides data collected in 1999, reviewed and analysed by a group of experts nominated by Member countries. The participating experts and the NEA and IAEA Secretariats endeavored to present consistent and comprehensive information on isotope uses and production in the world. It is recognised, however, that the data and analyses included in the report are by no means exhaustive. The views expressed in the document are those of the participating experts and do not necessarily represent those of the countries concerned. The report is published under the responsibility of the Secretary-General of the OECD. (author)

International laser safety standardization. From the European perspective with an emphasis on materials processing

Energy Technology Data Exchange (ETDEWEB)

Schulmeister, K [Div. of Life Sciences, Dept. of Radiation Protection, Oesterreichisches Forschungszentrum Seibersdorf, 2444 Seibersdorf (Austria)

1997-08-01

This report reviews international standards relevant to the safety of laser products and laser installations, with an emphasis on the safety of laser materials processing from the European perspective. In the first paragraphs an overview of the international standards organisations, their relative roles and ways of developing new standards is given. In the second part of the report, work currently underway in the respective standards committees is summarised and specific standards dealing with different aspects of laser safety are discussed. An appendix contains a list of standards organised in standards organisations (IEC, ISO and EN). (author)

International laser safety standardization. From the European perspective with an emphasis on materials processing

International Nuclear Information System (INIS)

Schulmeister, K.

1997-08-01

This report reviews international standards relevant to the safety of laser products and laser installations, with an emphasis on the safety of laser materials processing from the European perspective. In the first paragraphs an overview of the international standards organisations, their relative roles and ways of developing new standards is given. In the second part of the report, work currently underway in the respective standards committees is summarised and specific standards dealing with different aspects of laser safety are discussed. An appendix contains a list of standards organised in standards organisations IEC, ISO and EN). (author)

Uniform deposition of uranium hexafluoride (UF6): Standardized mass deposits and controlled isotopic ratios using a thermal fluorination method

Energy Technology Data Exchange (ETDEWEB)

McNamara, Bruce K.; O’Hara, Matthew J.; Casella, Andrew M.; Carter, Jennifer C.; Addleman, R. Shane; MacFarlan, Paul J.

2016-07-01

Abstract: We report a convenient method for the generation of volatile uranium hexafluoride (UF6) from solid uranium oxides and other uranium compounds, followed by uniform deposition of low levels of UF6 onto sampling coupons. Under laminar flow conditions, UF6 is shown to interact with surfaces within the chamber to a highly predictable degree. We demonstrate the preparation of uranium deposits that range between ~0.01 and 470±34 ng∙cm-2. The data suggest the method can be extended to creating depositions at the sub-picogram∙cm-2 level. Additionally, the isotopic composition of the deposits can be customized by selection of the uranium source materials. We demonstrate a layering technique whereby two uranium solids, each with a different isotopic composition, are employed to form successive layers of UF6 on a surface. The result is an ultra-thin deposit of UF6 that bears an isotopic signature that is a composite of the two uranium sources. The reported deposition method has direct application to the development of unique analytical standards for nuclear safeguards and forensics.

Existing and future international standards for the safety of radioactive waste disposal

International Nuclear Information System (INIS)

Linsley, G.

1999-01-01

In this paper the essential features of the current international safety standards are summarised and the issues being raised for inclusion in future standards are discussed. The safety standards of the IAEA are used as the basis for the review and discussion. The IAEA has established a process for establishing international standards of safety for radioactive waste management through its Radioactive Waste Safety Standards (RADWASS) programme. The RADWASS documents are approved by a comprehensive process involving regulatory and other experts from all concerned IAEA Member States. A system of committees for approving the IAEAs safety standards has been established. For radioactive waste safety the committee for review and approval is the Waste Safety Standards Advisory Committee (WASSAC). In 1995 the IAEA published 'The Principles of Radioactive Waste Management' as the top level document in the RADWASS programme. The report sets out the basis principles which most experts believe are fundamental to the safe management of radioactive wastes

Proceedings of V International Seminar and V National Workshop 'Use and development of products isotopic health industry'. 20th anniversary CENTIS

International Nuclear Information System (INIS)

2016-01-01

At the Salon Copa Room. Hotel Habana Riviera Took place the V International Seminar and V National Workshop 'Use and development of products isotopic health industry' for the 20th anniversary CENTIS. The event was organized by the Isotope Center. Some 200 domestic and foreign experts debated topics related to the development and production of radiopharmaceuticals in Cuba and the world, its therapeutic applications in certain tumors, and quality management systems in nuclear medicine. (author)

25 CFR 542.17 - What are the minimum internal control standards for complimentary services or items?

Science.gov (United States)

2010-04-01

... 25 Indians 2 2010-04-01 2010-04-01 false What are the minimum internal control standards for... THE INTERIOR HUMAN SERVICES MINIMUM INTERNAL CONTROL STANDARDS § 542.17 What are the minimum internal control standards for complimentary services or items? (a) Each Tribal gaming regulatory authority or...

Recently aspects regarding International Auditing Standard 200 „Overall Objectives of the Independent Auditor and the Conduct of an Audit in Accordance with International Standards on Auditing”

Directory of Open Access Journals (Sweden)

Daniel Botez

2009-12-01

Full Text Available The purpose of an audit is to enhance the degree of confidence of intended users in the financial statements. This is achieved by the expression of an opinion by the auditor on whether the financial statements are prepared, in all material respects, in accordance with an applicable financial reporting framework. The International Standard on Auditing 200 (ISA 200 deals with the independent auditor’s overall responsibilities when conducting an audit of financial statements in accordance with International Standards on Auditing (ISAs.

Software database creature for investment property measurement according to international standards

Science.gov (United States)

Ponomareva, S. V.; Merzliakova, N. A.

2018-05-01

The article deals with investment property measurement and accounting problems at the international, national and enterprise levels. The need to create the software for investment property measurement according to International Accounting Standards was substantiated. The necessary software functions and the processes were described.

The International Accounting Standards Board’s Progress in Promoting Judgement Through Objectives-Oriented Accounting Standards

OpenAIRE

Tanja Lakovic; Jayne Fuglister

2013-01-01

This study analyzes how the International Accounting Standards Board (IASB) promotes professional judgement by issuing objectives-oriented accounting standards and exposure drafts.  We focus on the the role of judgement as outlined in Phase I of the IASB Conceptual Framework (CF), Chapter 1, “Objective of General Purpose Financial Statements” and Chapter 3, “Qualitative Characteristics of Useful Financial Information” (IASB 2010). We discuss how the framework, when viewed through the prism of...

Isotope separation by standing waves

International Nuclear Information System (INIS)

Altshuler, S.

1984-01-01

The separation of isotopes is accomplished by scattering a beam of particles from a standing electromagnetic wave. The particles may consist of either atoms or molecules, the beam having in either case a desired isotope and at least one other. The particle beam is directed so as to impinge on the standing electromagnetic wave, which may be a light wave. The particles, that is, the atomic or molecular quantum-mechanical waves, see basically a diffraction grating corresponding to the troughs and peaks of the electromagnetic wave. The frequency of the standing electromagnetic wave substantially corresponds to an internal energy level-transition of the desired isotope. Accordingly, the desired isotope is spatially separated by being scattered or diffracted. (author)

A new feature in the internal heavy isotope distribution in ozone

International Nuclear Information System (INIS)

Bhattacharya, S. K.; Liang, Mao-Chang; Savarino, Joel; Michalski, G.

2014-01-01

Ozone produced by discharge or photolysis of oxygen has unusually heavy isotopic composition ( 18 O/ 16 O and 17 O/ 16 O ratio) which does not follow normal mass fractionation rule: δ 17 O ∼ 0.52 * δ 18 O, expressed as an anomaly Δ 17 O = δ 17 O − 0.52 * δ 18 O. Ozone molecule being an open isosceles triangle can have the heavy isotope located either in its apex or symmetric (s) position or the base or asymmetric (as) position. Correspondingly, one can define positional isotopic enrichment, written as δ 18 O (s) or δ 18 O (as) (and similarly for δ 17 O) as well as position dependent isotope anomaly Δ 17 O (s) and Δ 17 O (as). Marcus and co-workers have proposed a semi-empirical model based in principle on the RRKM model of uni-molecular dissociation but with slight modification (departure from statistical randomness assumption for symmetrical molecules) which explains many features of ozone isotopic enrichment. This model predicts that the bulk isotope anomaly is contained wholly in the asymmetric position and the Δ 17 O (s) is zero. Consequently, Δ 17 O (as) = 1.5 * Δ 17 O (bulk) (named here simply as the “1.5 rule”) which has been experimentally confirmed over a range of isotopic enrichment. We now show that a critical re-analysis of the earlier experimental data demonstrates a small but significant departure from this 1.5 rule at the highest and lowest levels of enrichments. This departure provides the first experimental proof that the dynamics of ozone formation differs from a statistical model constrained only by restriction of symmetry. We speculate over some possible causes for the departure

A new feature in the internal heavy isotope distribution in ozone

Science.gov (United States)

Bhattacharya, S. K.; Savarino, Joel; Michalski, G.; Liang, Mao-Chang

2014-10-01

Ozone produced by discharge or photolysis of oxygen has unusually heavy isotopic composition (18O/16O and 17O/16O ratio) which does not follow normal mass fractionation rule: δ17O ˜ 0.52*δ18O, expressed as an anomaly Δ17O = δ17O - 0.52*δ18O. Ozone molecule being an open isosceles triangle can have the heavy isotope located either in its apex or symmetric (s) position or the base or asymmetric (as) position. Correspondingly, one can define positional isotopic enrichment, written as δ18O (s) or δ18O (as) (and similarly for δ17O) as well as position dependent isotope anomaly Δ17O (s) and Δ17O (as). Marcus and co-workers have proposed a semi-empirical model based in principle on the RRKM model of uni-molecular dissociation but with slight modification (departure from statistical randomness assumption for symmetrical molecules) which explains many features of ozone isotopic enrichment. This model predicts that the bulk isotope anomaly is contained wholly in the asymmetric position and the Δ17O (s) is zero. Consequently, Δ17O (as) = 1.5 * Δ17O (bulk) (named here simply as the "1.5 rule") which has been experimentally confirmed over a range of isotopic enrichment. We now show that a critical re-analysis of the earlier experimental data demonstrates a small but significant departure from this 1.5 rule at the highest and lowest levels of enrichments. This departure provides the first experimental proof that the dynamics of ozone formation differs from a statistical model constrained only by restriction of symmetry. We speculate over some possible causes for the departure.

The Inclusion of Standard Terms in International Sales Contracts

Directory of Open Access Journals (Sweden)

S Eiselen

2011-04-01

Full Text Available The problem dealing with the inclusion of standard terms and conditions in contracts is a problem that has engaged most legal systems. The United Nations Convention on Contracts for the International Sale of Goods, Vienna 1980 (CISG does not expressly deal with this problem. Accordingly the solution to the issue must be found in an interpretation and application of the general principles found in articles 8, 14 and 18. One of the main objects of the CISG is the harmonisation of international trade law. It is generally recognised that in order to achieve harmonisation it isnecessary that courts should interpret and apply the convention in a consistent and harmonious manner. Unfortunately a number of approaches have emerged from courts around the world in regard to the inclusion of standard terms. German courts have developed a strict approach which requires that the standard terms be madeavailable to the addressee at the time of the conclusion of the contract. They also require that the standard terms be couched in the language of the main contract. In stark contrast an American court has used an approach which is very lax in regard to incorporation, even allowing incorporation after the conclusion of the contract. There is, however a more moderate approach set out in decisions of the Austrian Supreme Court where the court adopted an approach which is more akin to that found in most legal systems, namely that a clear incorporation clause in the contract is sufficient for the effective incorporation of standard terms. The author critically examines the case law, the various approaches and the underlying arguments on which they are based, before reaching the conclusion that the two extreme approaches should be rejected in favour of the more moderate approach. This approach is founded on aproper interpretation of the provisions of the CISG as well as being in step with international trade practice.

Regulatory practices and standards: the international scene and trends

International Nuclear Information System (INIS)

Vinck, W.; Essler, W.; Maurer, H.A.; Reijen, G. van.

1978-01-01

At national level, codification of standards governing the licensing and operation of nuclear installations is very different, ranging from criteria to regulations, according to the degree of the obligation imposed by national authorities; it also reflects the variety of national situations and the peculiarities of the legal and political systems. The need to agree upon a level of nuclear safety which is generally recognised as satisfactory and to exchange scientific and technological information in this field has greatly stimulated international co-operation, in particular within the framework of specialized international organisations such as IAEA, ISO, Euratom and OECD/NEA. Harmonization of such standards is particularly important from the viewpoint of public opinion in the countries concerned. In addition, the intrinsic safety of nuclear power plants, assurances as to the duration of plant life should increasingly be highlighted in future. (NEA) [fr

Seminar on standards, standardization, quality control and interlaboratory test programmes

Energy Technology Data Exchange (ETDEWEB)

de Bievre, P. [Central Bureau for Nuclear Measurements, Geel (Belgium)

1978-12-15

The author gives a resume on the proper use of standards and standardization of measurement procedures. Results of measurements obtained on the same instrument and on the same series of standards of different isotopic compositions are displayed.

Finite element analyses for Seismic Shear Wall International Standard Problem

International Nuclear Information System (INIS)

Park, Y.; Hofmayer, C.; Chokshi, N.

1997-01-01

In the seismic design of shear wall structures, e.g., nuclear reactor buildings, a linear FEM analysis is frequently used to quantify the stresses under the design loading condition. The final design decisions, however, are still based on empirical design rules established over decades from accumulated laboratory test data. This paper presents an overview of the state-of-the-art on the application of nonlinear FEM analysis to reinforced concrete (RC) shear wall structures under severe earthquake loadings based on the findings obtained during the Seismic Shear Wall International Standard Problem (SSWISP) Workshop in 1996. Also, BNL's analysis results of the International Standard Problem (ISP) shear walls under monotonic static, cyclic static and dynamic loading conditions are described

76 FR 12863 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2011-03-09

... National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines... combustion engines. The final rule was published on August 20, 2010. This direct final action amends certain... Emission Standards for Hazardous Air Pollutant for Stationary Reciprocating Internal Combustion Engines...

Use of AERIN code for determining internal doses of transuranic isotopes

International Nuclear Information System (INIS)

King, W.C.

1980-01-01

The AERIN computer code is a mathematical expression of the ICRP Lung Model. The code was developed at the Lawrence Livermore National Laboratory to compute the body organ burdens and absorbed radiation doses resulting from the inhalation of transuranic isotopes and to predict the amount of activity excreted in the urine and feces as a function of time. Over forty cases of internal exposure have been studied using the AERIN code. The code, as modified, has proven to be extremely versatile. The case studies presented demonstrate the excellent correlation that can be obtained between code predictions and observed bioassay data. In one case study a discrepancy was observed between an in vivo count of the whole body and the application of the code using urine and fecal data as input. The discrepancy was resolved by in vivo skull counts that showed the code had predicted the correct skeletal burden

Evaluation of precision in measurements of uranium isotope ratio by thermionic mass spectrometry

International Nuclear Information System (INIS)

Moraes, N.M.P. de; Rodrigues, C.

1977-01-01

The parameters which affect the precision and accuracy of uranium isotopic ratios measurements by thermionic mass spectrometry are discussed. A statistical designed program for the analysis of the internal and external variances are presented. It was done an application of this statistical methods, in order to get mass discrimination factor, and its standard mean deviation, by using some results already published for 235 U/ 238 U ratio in NBS uranium samples, and natural uranium [pt

(No) Limits to Anglo-American Accounting? Reconstructing the History of the International Accounting Standards Committee ; A Review Article

OpenAIRE

Botzem, S.; Quack, S.

2009-01-01

The development of the current International Accounting Standards Board (IASB) from the earlier International Accounting Standards Committee (IASC) provides insight into many issues of international financial reporting, among them the characteristics of international accounting standards themselves. This article reviews Camfferman and Zeff’s [Camfferman, K., & Zeff, S. A. (2007). Financial reporting and global capital markets. A history of the international accounting standards committee 1973...

A measurement control program for plutonium isotopic gamma-ray systems at the Rocky Flats Plant

International Nuclear Information System (INIS)

Fleissner, J.G.

1986-01-01

A sound measurement control (MC) program should be an integral part of every nondestructive assay measurement system used for the assay of special nuclear materials. This paper describes a measurement control program for plutonium isotopic composition measurements, using high-resolution gamma-ray spectroscopy, that has been implemented in the Analytical Laboratories and the Chemistry Standards Laboratory at the Rocky Flats Plant. This MC program emphasizes the standardization of data collection procedures along with the implementation of internal and external measurement control checks to provide the requisite measurement quality assurance

Enriching stable isotopes: Alternative use for Urenco technology

International Nuclear Information System (INIS)

Rakhorst, H.; de Jong, P.G.T.; Dawson, P.D.

1996-01-01

The International Urenco Group utilizes a technologically advanced centrifuge process to enrich uranium in the fissionable isotope 235 U. The group operates plants in the United Kingdom, the Netherlands, and Germany and currently holds a 10% share of the multibillion dollar world enrichment market. In the early 1990s, Urenco embarked on a strategy of building on the company's uniquely advanced centrifuge process and laser isotope separation (LIS) experience to enrich nonradioactive isotopes colloquially known as stable isotopes. This paper summarizes the present status of Urenco's stable isotopes business

Fabrication of 12% 240Pu calorimetry standards

International Nuclear Information System (INIS)

Long, S.M.; Hildner, S.; Gutierrez, D.; Mills, C.; Garcia, W.; Gurule, C.

1995-01-01

Throughout the DOE complex, laboratories are performing calorimetric assays on items containing high burnup plutonium. These materials contain higher isotopic range and higher wattages than materials previously encountered in vault holdings. Currently, measurement control standards have been limited to utilizing 6% 240 Pu standards. The lower isotopic and wattage value standards do not complement the measurement of the higher burnup material. Participants of the Calorimetry Exchange (CALEX) Program have identified the need for new calorimetric assay standards with a higher wattage and isotopic range. This paper describes the fabrication and verification measurements of the new CALEX standard containing 12% 240 Pu oxide with a wattage of about 6 to 8 watts

An overview of prisons, prisoners and international human rights standards

Directory of Open Access Journals (Sweden)

Andrew Coyle

2012-07-01

Full Text Available This article examines the principal international human rights standards that exist for the treatment of prisoners. Given the increase in the use of  imprisonment in many countries, the administration of prisons poses certain challenges. The author addresses this issue by first examining the purposes of imprisonment, which is the only way to evaluate if the penitentiary system is achieving the goals that have been set for it. The author then analyzes five elements that must be taken into account when complying with international standards regarding the treatment of prisoners: living conditions for prisoners; the contact that prisoners have with their families and other persons; special conditions that apply to incarcerated persons according to specific situations (gender, nationality, age, illness, etc.; prison personnel and independent oversight of prisons. In the end, what all of these  standards have in common is the importance of upholding human dignity when dealing with incarcerated persons.

II. The Standard Model in the Isotopic Foldy-Wouthuysen Representation without Higgs Bosons in the Fermion Sector. Spontaneous Breaking of Parity and "Dark Matter" Problems

OpenAIRE

Neznamov, V. P.

2011-01-01

The Standard Model with massive fermions is formulated in the isotopic Foldy-Wouthuysen representation. SU(2)xU(1) - invariance of the theory in this representation is independent of whether fermions possess mass or not, and, consequently, it is not necessary to introduce interactions between Higgs bosons and fermions. The study discusses a possible relation between spontaneous breaking of parity in the isotopic Foldy-Wouthuysen representation and the composition of elementary particles of "d...

Isotope techniques in the study of environmental change

International Nuclear Information System (INIS)

1998-01-01

The International Atomic Energy Agency, among its efforts to promote the wider use of isotope techniques in hydrology and related environmental disciplines, organized an International Symposium on Applications of Isotope Techniques in Studying Past and Current Environmental Changes in the Hydrosphere and the Atmosphere, held in 1993 in Vienna. The broad scientific interest and abundant participation in the symposium, as well as the rapid progress seen in this field since then, encouraged the IAEA to organize a second symposium of this kind. It was held from 14 to 18 April 1997 in Vienna and brought together 177 scientists representing 46 Member States, UNESCO, FAO, WMO, the World Climate Research Programme (WCRP) and the International Geosphere-Biosphere Programme (IGBP). The symposium was structured in five sessions of oral presentations, a poster session and a round table discussion that focused on trends and future requirements in isotope hydrology and on applications in climate and environmental research. The major themes covered by the presentations included the use of isotopic tracers in studies of atmospheric and hydrospheric changes and of the human impact on water and the environment. Special emphasis was placed on isotopic archives of climatic and environmental change. Some contributions addressed new technical approaches

78 FR 14457 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2013-03-06

... ENVIRONMENTAL PROTECTION AGENCY 40 CFR Parts 60 and 63 [EPA-HQ-OAR-2008-0708, FRL-9756-4] RIN 2060-AQ58 National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines; New Source Performance Standards for Stationary Internal Combustion Engines Correction In rule...

Developing international safety standards for the geological disposal of radioactive waste

International Nuclear Information System (INIS)

Metcalf, P.

2001-01-01

In the context of the International Atomic Energy Agency's (IAEA) programme to create a corpus of internationally accepted Radioactive Waste Safety Standards (RADWASS), focus is currently being placed on establishing standards for the 'geological disposal of radioactive waste'. This is a challenging task and to help the standards development process there is a need to stimulate discussion of some of the associated scientific and technical issues. A number of position papers developed in recent years by a subgroup of the Waste Safety Standards Committee (WASSC), the subgroup on Principles and Criteria for Radioactive Waste Disposal, address many of the relevant issues. These include a common safety based framework for radioactive waste disposal, appropriate time frames for safety assessment, different possible indicators of long-term safety, the safety implications of reversibility and retrievability, the assessment of possible human intrusion into the repository, the role and limitations of institutional control, establishing reference critical groups and biospheres for long-term assessment, and what is meant by 'compliance' with the standards. These papers will be discussed at a Specialists Meeting to be held at the IAEA in June 2001 as a means of establishing the extent to which they enjoy the general support of experts. In order to broaden that consensus, the conclusions reached at the Specialists Meeting on the issues listed above will be presented and discussed with participants at a number of international meetings. Later this year, a draft safety standard on the geological disposal of radioactive waste which takes account of the consensus positions reached through the various consultations will be submitted for the consideration of Waste Safety Standards Committee (WASSC), the officially approved body within the IAEA for the review and approval of waste safety standards. The Committee is made up of government appointed radioactive waste regulators

To recognize the use of international standards for making harmonized regulation of medical devices in Asia-pacific.

Science.gov (United States)

Anand, K; Saini, Ks; Chopra, Y; Binod, Sk

2010-07-01

'Medical Devices' include everything from highly sophisticated, computerized, medical equipment, right down to simple wooden tongue depressors. Regulations embody the public expectations for how buildings and facilities are expected to perform and as such represent public policy. Regulators, who develop and enforce regulations, are empowered to act in the public's interest to set this policy and are ultimately responsible to the public in this regard. Standardization contributes to the basic infrastructure that underpins society including health and environment, while promoting sustainability and good regulatory practice. The international organizations that produce International Standards are the International Electrotechnical Commission (IEC), the International Organization for Standardization (ISO), and the International Telecommunication Union (ITU). With the increasing globalization of markets, International Standards (as opposed to regional or national standards) have become critical to the trading process, ensuring a level playing field for exports, and ensuring that imports meet the internationally recognized levels of performance and safety. The development of standards is done in response to sectors and stakeholders that express a clearly established need for them. An industry sector or other stakeholder group typically communicates its requirement for standards to one of the national members. To be accepted for development, a proposed work item must receive a majority support of the participating members, who verify the global relevance of the proposed item. The regulatory authority (RA) should provide a method for the recognition of international voluntary standards and for public notification of such recognition. The process of recognition may vary from country to country. Recognition may occur by periodic publication of lists of standards that a regulatory authority has found will meet the Essential Principles. In conclusion, International standards

Copper and tin isotopic analysis of ancient bronzes for archaeological investigation: development and validation of a suitable analytical methodology.

Science.gov (United States)

Balliana, Eleonora; Aramendía, Maite; Resano, Martin; Barbante, Carlo; Vanhaecke, Frank

2013-03-01

Although in many cases Pb isotopic analysis can be relied on for provenance determination of ancient bronzes, sometimes the use of "non-traditional" isotopic systems, such as those of Cu and Sn, is required. The work reported on in this paper aimed at revising the methodology for Cu and Sn isotope ratio measurements in archaeological bronzes via optimization of the analytical procedures in terms of sample pre-treatment, measurement protocol, precision, and analytical uncertainty. For Cu isotopic analysis, both Zn and Ni were investigated for their merit as internal standard (IS) relied on for mass bias correction. The use of Ni as IS seems to be the most robust approach as Ni is less prone to contamination, has a lower abundance in bronzes and an ionization potential similar to that of Cu, and provides slightly better reproducibility values when applied to NIST SRM 976 Cu isotopic reference material. The possibility of carrying out direct isotopic analysis without prior Cu isolation (with AG-MP-1 anion exchange resin) was investigated by analysis of CRM IARM 91D bronze reference material, synthetic solutions, and archaeological bronzes. Both procedures (Cu isolation/no Cu isolation) provide similar δ (65)Cu results with similar uncertainty budgets in all cases (±0.02-0.04 per mil in delta units, k = 2, n = 4). Direct isotopic analysis of Cu therefore seems feasible, without evidence of spectral interference or matrix-induced effect on the extent of mass bias. For Sn, a separation protocol relying on TRU-Spec anion exchange resin was optimized, providing a recovery close to 100 % without on-column fractionation. Cu was recovered quantitatively together with the bronze matrix with this isolation protocol. Isotopic analysis of this Cu fraction provides δ (65)Cu results similar to those obtained upon isolation using AG-MP-1 resin. This means that Cu and Sn isotopic analysis of bronze alloys can therefore be carried out after a single chromatographic

Discourse Surrounding the International Education Standards for Professional Accountants (IES): A Content Analysis Approach

Science.gov (United States)

Sugahara, Satoshi; Wilson, Rachel

2013-01-01

The development and implementation of the International Education Standards (IES) for professional accountants is currently an important issue in accounting education and for educators interested in a shift toward international education standards more broadly. The purpose of this study is to investigate professional and research discourse…

Standard test method for analysis of total and isotopic uranium and total thorium in soils by inductively coupled plasma-mass spectrometry

CERN Document Server

American Society for Testing and Materials. Philadelphia

2008-01-01

1.1 This test method covers the measurement of total uranium (U) and thorium (Th) concentrations in soils, as well as the determination of the isotopic weight percentages of 234U, 235U, 236U, and 238U, thereby allowing for the calculation of individual isotopic uranium activity or total uranium activity. This inductively coupled plasma-mass spectroscopy (ICP-MS) method is intended as an alternative analysis to methods such as alpha spectroscopy or thermal ionization mass spectroscopy (TIMS). Also, while this test method covers only those isotopes listed above, the instrumental technique may be expanded to cover other long-lived radioisotopes since the preparation technique includes the preconcentration of the actinide series of elements. The resultant sample volume can be further reduced for introduction into the ICP-MS via an electrothermal vaporization (ETV) unit or other sample introduction device, even though the standard peristaltic pump introduction is applied for this test method. The sample preparatio...

[International Standards of Tuberculosis Care (ISTC)--comments from the German point of view].

Science.gov (United States)

Castell, S; Bauer, T; Diel, R; Hedrich, A; Magdorf, K; Rüsch-Gerdes, S; Schaberg, T; Loddenkemper, R

2012-04-01

The "International Standards for Tuberculosis Care" (ISTC) were developed by the World Health Organisation (WHO) and others to provide internationally agreed and, if possible, evidence-based standards for tuberculosis care including the care by private providers who are not part of national tuberculosis programmes or health-care systems. Hence, the ISTC primarily address resource-restrained countries with high tuberculosis prevalence. In this article, the German translation of the 21 standards from 2009 is presented - addressing diagnostic and therapeutic standards, co-infection (especially with HIV) and public-health issues. The accompanying comments show how these standards have to be modified for Germany due to the medical resources available here and country-specific characteristics respectively. © Georg Thieme Verlag KG Stuttgart · New York.

Beneficial uses and production of isotopes

CERN Document Server

2001-01-01

Isotopes, radioactive and stable, are used worldwide in various applications related to medical diagnosis or care, industry and scientific research. More than fifty countries have isotope production or separation facilities operated for domestic supply, and sometimes for international markets. This publication provides up-to-date information on the current status of, and trends in, isotope uses and production. It also presents key issues, conclusions and recommendations, which will be of interest to policy makers in governmental bodies, scientists and industrial actors in the field.

Platinum stable isotope ratio measurements by double-spike multiple collector ICPMS

DEFF Research Database (Denmark)

Creech, John; Baker, Joel; Handler, Monica

2013-01-01

We present a new technique for the precise determination of platinum (Pt) stable isotope ratios by multiple-collector inductively coupled plasma mass spectrometry (MC-ICPMS) using two different Pt double-spikes ( Pt-Pt and Pt-Pt). Results are expressed relative to the IRMM-010 Pt isotope standard......) can be obtained on Pt stable isotope ratios with either double-spike. Elemental doping tests reveal that double-spike corrected Pt stable isotope ratios are insensitive to the presence of relatively high (up to 10%) levels of matrix elements, although the Pt-Pt double-spike is affected by an isobaric...... = 7.308%) results in a redefined Pt atomic weight of 195.08395 ± 0.00068. Using our technique we have measured small, reproducible and statistically significant offsets in Pt stable isotope ratios between different Pt element standards and the IRMM-010 standard, which potentially indicates...

Stable isotope labeling – Liquid chromatography/mass spectrometry for quantitative analysis of androgenic and progestagenic steroids

International Nuclear Information System (INIS)

Guo, Ning; Liu, Ping; Ding, Jun; Zheng, Shu-Jian; Yuan, Bi-Feng; Feng, Yu-Qi

2016-01-01

Steroid hormones play important roles in mammal at very low concentrations and are associated with numerous endocrinology and oncology diseases. Therefore, quantitative analysis of steroid hormones can provide crucial information for uncovering underlying mechanisms of steroid hormones related diseases. In the current study, we developed a sensitive method for the detection of steroid hormones (progesterone, dehydroepiandrosterone, testosterone, pregnenolone, 17-hydroxyprogesterone, androstenedione and 17α-hydroxypregnenolone) in body fluids by stable isotope labeling coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analysis. In this respect, a pair of isotopes labeling reagents, Girard reagent P (GP) and d_5-Girard reagent P (d_5-GP), were synthesized and utilized to label steroid hormones in follicular fluid samples and steroid hormone standards, respectively. The heavy labeled standards were used as internal standards for quantification to minimize quantitation deviation in MS analysis due to the matrix and ion suppression effects. The ionization efficiencies of steroid hormones were greatly improved by 4–504 folds through the introduction of a permanent charged moiety of quaternary ammonium from GP. Using the developed method, we successfully quantified steroid hormones in human follicular fluid. We found that the contents of testosterone and androstenedione exhibited significant increase while the content of pregnenolone had significant decrease in follicular fluid of polycystic ovarian syndrome (PCOS) patients compared with healthy controls, indicating that these steroid hormones with significant change may contribute to the pathogenesis of PCOS. Taken together, the developed stable isotope labeling coupled LC-ESI-MS/MS analysis demonstrated to be a promising method for the sensitive and accurate determination of steroid hormones, which may facilitate the in-depth investigation of steroid hormones related

Stable isotope labeling – Liquid chromatography/mass spectrometry for quantitative analysis of androgenic and progestagenic steroids

Energy Technology Data Exchange (ETDEWEB)

Guo, Ning; Liu, Ping; Ding, Jun; Zheng, Shu-Jian; Yuan, Bi-Feng; Feng, Yu-Qi, E-mail: yqfeng@whu.edu.cn

2016-01-28

Steroid hormones play important roles in mammal at very low concentrations and are associated with numerous endocrinology and oncology diseases. Therefore, quantitative analysis of steroid hormones can provide crucial information for uncovering underlying mechanisms of steroid hormones related diseases. In the current study, we developed a sensitive method for the detection of steroid hormones (progesterone, dehydroepiandrosterone, testosterone, pregnenolone, 17-hydroxyprogesterone, androstenedione and 17α-hydroxypregnenolone) in body fluids by stable isotope labeling coupled with liquid chromatography-electrospray ionization-tandem mass spectrometry (LC-ESI-MS/MS) analysis. In this respect, a pair of isotopes labeling reagents, Girard reagent P (GP) and d{sub 5}-Girard reagent P (d{sub 5}-GP), were synthesized and utilized to label steroid hormones in follicular fluid samples and steroid hormone standards, respectively. The heavy labeled standards were used as internal standards for quantification to minimize quantitation deviation in MS analysis due to the matrix and ion suppression effects. The ionization efficiencies of steroid hormones were greatly improved by 4–504 folds through the introduction of a permanent charged moiety of quaternary ammonium from GP. Using the developed method, we successfully quantified steroid hormones in human follicular fluid. We found that the contents of testosterone and androstenedione exhibited significant increase while the content of pregnenolone had significant decrease in follicular fluid of polycystic ovarian syndrome (PCOS) patients compared with healthy controls, indicating that these steroid hormones with significant change may contribute to the pathogenesis of PCOS. Taken together, the developed stable isotope labeling coupled LC-ESI-MS/MS analysis demonstrated to be a promising method for the sensitive and accurate determination of steroid hormones, which may facilitate the in-depth investigation of steroid hormones

New Organic Stable Isotope Reference Materials for Distribution through the USGS and the IAEA

Science.gov (United States)

Schimmelmann, Arndt; Qi, Haiping

2014-05-01

The widespread adoption of relative stable isotope-ratio measurements in organic matter by diverse scientific disciplines is at odds with the dearth of international organic stable isotopic reference materials (RMs). Only two of the few carbon (C) and nitrogen (N) organic RMs, namely L-glutamic acids USGS40 and USGS41 [1], both available from the U.S. Geological Survey (USGS) and the International Atomic Energy Agency (IAEA), provide an isotopically contrasting pair of organic RMs to enable essential 2-point calibrations for δ-scale normalization [2, 3]. The supply of hydrogen (H) organic RMs is even more limited. Numerous stable isotope laboratories have resorted to questionable practices, for example by using 'CO2, N2, and H2 reference gas pulses' for isotopic calibrations, which violates the principle of identical treatment of sample and standard (i.e., organic unknowns should be calibrated directly against chemically similar organic RMs) [4], or by using only 1 anchor instead of 2 for scale calibration. The absence of international organic RMs frequently serves as an excuse for indefensible calibrations. In 2011, the U.S. National Science Foundation (NSF) funded an initiative of 10 laboratories from 7 countries to jointly develop much needed new organic RMs for future distribution by the USGS and the IAEA. The selection of targeted RMs attempts to cover various common compound classes of broad technical and scientific interest. We had to accept compromises to approach the ideal of high chemical stability, lack of toxicity, and low price of raw materials. Hazardous gases and flammable liquids were avoided in order to facilitate international shipping of future RMs. With the exception of polyethylene and vacuum pump oil, all organic RMs are individual, chemically-pure substances, which can be used for compound-specific isotopic measurements in conjunction with liquid and gas chromatographic interfaces. The compounds listed below are under isotopic calibration by

A New International Standard for "Actions from Waves and Currents on Coastal Structures"

DEFF Research Database (Denmark)

Tørum, Alf; Burcharth, Hans F.; Goda, Yoshimi

2007-01-01

The International Organization for Standardization (ISO) is going to issue a new standard concerning "Actions from Waves and Currents on Coastal Structures," which becomes the first international standard in coastal engineering. It is composed of a normative part (29 pages), an informative part (80...... pages) and Bibliography ( 17 pages). The normative part describes what is considered as the norm of the matters in concern, while the informative part provides the information on recommended practice. The paper introduces the main points of the normative part and discusses the influence of the new...

Isotope techniques in water resources development and management. Proceedings

International Nuclear Information System (INIS)

1999-01-01

The 10th International Symposium on Isotope Techniques in Water Resources Development and Management was organized by the International Atomic Energy Agency in co-operation with UNESCO, WMO and International Association of Hydrological Sciences and was held at IAEA Headquarters, Vienna, during 10-14 May 1999. The symposium provided an international forum for assessing the status and recent advances in isotope applications to water resources and an exchange of information on the following main themes: processes at the interface between the atmosphere and hydrosphere; investigations in surface waters and groundwaters: their origin, dynamics, interrelations; problems and techniques for investigating sedimentation; water resources issues: pollution, source and transport of contaminants, salinization, water-rock interaction and processes in geothermal systems; isotope data interpretation and evaluation methodologies: modelling approaches. The proceedings contain the 46 papers presented and extended synopses of poster presentations; each of them was indexed individually

Tin isotope fractionation during magmatic processes and the isotope composition of the bulk silicate Earth

Science.gov (United States)

Wang, Xueying; Amet, Quentin; Fitoussi, Caroline; Bourdon, Bernard

2018-05-01

Tin is a moderately volatile element whose isotope composition can be used to investigate Earth and planet differentiation and the early history of the Solar System. Although the Sn stable isotope composition of several geological and archaeological samples has been reported, there is currently scarce information about the effect of igneous processes on Sn isotopes. In this study, high-precision Sn isotope measurements of peridotites and basalts were obtained by MC-ICP-MS with a double-spike technique. The basalt samples display small variations in δ124/116Sn ranging from -0.01 ± 0.11 to 0.27 ± 0.11‰ (2 s.d.) relative to NIST SRM 3161a standard solution, while peridotites have more dispersed and more negative δ124Sn values ranging from -1.04 ± 0.11 to -0.07 ± 0.11‰ (2 s.d.). Overall, basalts are enriched in heavy Sn isotopes relative to peridotites. In addition, δ124Sn in peridotites become more negative with increasing degrees of melt depletion. These results can be explained by different partitioning behavior of Sn4+ and Sn2+ during partial melting. Sn4+ is overall more incompatible than Sn2+ during partial melting, resulting in Sn4+-rich silicate melt and Sn2+-rich residue. As Sn4+ has been shown experimentally to be enriched in heavy isotopes relative to Sn2+, the effect of melting is to enrich residual peridotites in relatively more compatible Sn2+, which results in isotopically lighter peridotites and isotopically heavier mantle-derived melts. This picture can be disturbed partly by the effect of refertilization. Similarly, the presence of enriched components such as recycled oceanic crust or sediments could explain part of the variations in Sn isotopes in oceanic basalts. The most primitive peridotite analyzed in this study was used for estimating the Sn isotope composition of the BSE, with δ124Sn = -0.08 ± 0.11‰ (2 s.d.) relative to the Sn NIST SRM 3161a standard solution. Altogether, this suggests that Sn isotopes may be a powerful probe of

Uniform deposition of uranium hexafluoride (UF6): Standardized mass deposits and controlled isotopic ratios using a thermal fluorination method.

Science.gov (United States)

McNamara, Bruce K; O'Hara, Matthew J; Casella, Andrew M; Carter, Jennifer C; Addleman, R Shane; MacFarlan, Paul J

2016-07-01

We report a convenient method for the generation of volatile uranium hexafluoride (UF6) from solid uranium oxides and other U compounds, followed by uniform deposition of low levels of UF6 onto sampling coupons. Under laminar flow conditions, UF6 is shown to interact with surfaces within a fixed reactor geometry to a highly predictable degree. We demonstrate the preparation of U deposits that range between approximately 0.01 and 500ngcm(-2). The data suggest the method can be extended to creating depositions at the sub-picogramcm(-2) level. The isotopic composition of the deposits can be customized by selection of the U source materials and we demonstrate a layering technique whereby two U solids, each with a different isotopic composition, are employed to form successive layers of UF6 on a surface. The result is an ultra-thin deposit that bears an isotopic signature that is a composite of the two U sources. The reported deposition method has direct application to the development of unique analytical standards for nuclear safeguards and forensics. Further, the method allows access to very low atomic or molecular coverages of surfaces. Copyright © 2016 Elsevier B.V. All rights reserved.

EPR meeting international safety standards with margin

International Nuclear Information System (INIS)

Mazurkiewicz, S.M.; Brauns, J.; Blombach, J.

2005-01-01

The EPR provides technology that offers a solution to the market's need for safe, economic power. The EPR was originally developed through a joint effort between Framatome ANP and Siemens by incorporating the best technological features from the French and German nuclear reactor fleets into a cost-competitive product capable of international licensing. As such, the EPR is a global product with commercial units currently being built in Finland at the Olkiluoto site, and planned for France, at the Flamanville site. Framatome ANP has recently proposed four EPR units to China in response to a request for vendor bids. In addition, Framatome ANP has announced their intent to pursue design certification with the United States Nuclear Regulatory Commission (NRC). This paper discusses how EPR's innovative safety philosophy ensures compliance with international safety standards for advanced light-water reactors (ALWRs). (author)

EPR meeting international safety standards with margin

International Nuclear Information System (INIS)

Mazurkiewicz, S.M.; Brauns, J.; Blombach, J.

2005-01-01

The EPR provides technology that offers a solution to the market's need for safe, economic power. The EPR was originally developed through a joint effort between Framatome ANP and Siemens by incorporating the best technological features from the French and German nuclear reactor fleets into a cost-competitive product capable of international licensing. As such, the EPR is a global product with commercial units currently being built in Finland at the Olkiluoto site, and planned for France, at the Flamanville site. Framatome ANP has recently proposed four EPR units to China in response to a request for vendor bids. In addition, Framatome ANP has announced their intent to pursue design certification in with the United States Nuclear Regulatory Commission (NRC). This paper discusses how EPR's innovative safety philosophy ensures compliance with international safety standards for advanced light-water reactors (ALWRs). (author)

[Determination of deuterium concentration in foods and influence of water with modified isotopic composition on oxidation parameters and heavy hydrogen isotopes content in experimental animals].

Science.gov (United States)

Basov, A A; Bykov, I M; Baryshev, M G; Dzhimak, S S; Bykov, M I

2014-01-01

The article presents the results of the study of the deuterium (D) content in food products as well as the influence of deuterium depleted water (DDW) on the concentration of heavy hydrogen isotopes in the blood and lyophilized tissues of rats. The most significant difference in the content of D was found between potato and pork fat, which indexes the standard delta notation (δ) D in promille, related to the international standard SMOW (Standard Mean Ocean of Water) amounted to -83,2 per thousand and -250,7 per thousand, respectively (phydrogen atoms in the body. The data obtained in the experimental modeling of the diet of male Wistar rats in the age of 5-6 mo (weight 235 ± 16 g) using DDW (δD = -743,2 per thousand) instead of drinking water (δD = -37,0 per thousand) with identical mineral composition showed that after 2 weeks significant (p tissue") is due to different rates ofisotopic exchange reactions in plasma and tissues (liver, kidney, heart), which can be explained by entering into the composition of a modified diet of organic substrates with more than DDW concentration D, which are involved in the construction of cellular structures and eventually lead to a redistribution of D and change direction of D/H gradient "plasmaisotopic composition, aimed at reducing the level of heavy non-radioactive atoms will allow the targeted nutritional correction of prooxidant-antioxidant status of the population in areas with adverse environmental conditions, stimulating by created isotopic D/H gradient cytoprotective mechanisms influencing the various components of nonspecific protection, including free radical oxidation processes. And then again, periodic assessment of the isotopic composition of nutrients will monitor the quality of food consumed by the population, and if

Isotope dilution inductively coupled plasma mass spectrometry (ID ICP-MS) for the certification of lead and cadmium in environmental standard reference materials.

Science.gov (United States)

Murphy, K E; Beary, E S; Rearick, M S; Vocke, R D

2000-10-01

Lead (Pb) and cadmium (Cd) have been determined in six new environmental standard reference materials (SRMs) using isotope dilution inductively coupled plasma mass spectrometry (ID ICP-MS). The SRMs are the following: SRM 1944, New York-New Jersey Waterway Sediment, SRMs 2583 and 2584, Trace Elements in Indoor Dust, Nominal 90 mg/kg and 10,000 mg/kg Lead, respectively, SRMs 2586 and 2587, Trace Elements in Soil Containing Lead from Paint, Nominal 500 mg/kg and 3,000 mg/kg Lead, respectively, and SRM 2782, Industrial Sludge. The capabilities of ID ICP-MS for the certification of Pb and Cd in these materials are assessed. Sample preparation and ratio measurement uncertainties have been evaluated. Reproducibility and accuracy of the established procedures are demonstrated by determination of gravimetrically prepared primary standard solutions and by comparison with isotope dilution thermal ionization mass spectrometry (ID TIMS). Material heterogeneity was readily demonstrated to be the dominant source of uncertainty in the certified values.

The Development Standard Agreement Influences on National and International Business Practices

Directory of Open Access Journals (Sweden)

Cindawati Cindawati

2016-12-01

Full Text Available The rapidly growing business traffic either nationally or internationally forces the business practices to establish a standard agreement to secure the products and to protect the buyer from any risks. The standard agreement successfully meets the demand of international trade which urgently need the high speed and the accuracy. The objective of this research is to find out how does the development of agreement affect to the commerce practices and what are the requirements of standard agreement in accordance with the right and obligation. A qualitative method is applied in searching data of business practices. This study uses a normative research which guides the rule of law or determines some business standards and norms. The finding of this study show that the development of agreement strongly affects to the commerce practices, and standar agreement is urgently needed by business practices as a guideline to perform business traffic as smooth as buyer and seller expect, then both seller and buyer should know the three alternative way used as the procedures of standard agreement, namely; contract signing, notification document agreement, and notification by bulletin board. At last, a standard agreement could be accepted as legal agreement corresponding to willingness and trustworthy.

Zinc Finger Takes on a Whole New Meaning: Reducing and Monitoring Zinc Blanks in the Isotope Lab

Science.gov (United States)

Wilkes, E. B.; Wasylenki, L. E.; Anbar, A. D.

2010-12-01

zinc isotope ratios that most natural samples are similar in isotopic composition to the gloves we measured and to JMC-Lyon Zn, which has become an informally accepted international standard. When measuring natural samples whose isotopic compositions are similar to that of gloves used in sample processing, it is not possible to know when the measured values reflect varying extents of contamination from gloves, rather than the true compositions of the samples. Using truly low-zinc gloves during sample processing or avoiding gloves and the residue gloves can leave on lab surfaces is likely the best way to ensure accurate determination of zinc isotope composition. Extremely careful monitoring of ion exchange chemistry yields is also recommended, although this requires using element-spiking rather than double-spiking for mass bias correction.

The protection of migrant workers and international labour standards.

Science.gov (United States)

Bohning, W R

1988-06-01

International labor standards take the form of Conventions and Recommendations that embody the agreements reached by a 2/3 majority of the representatives of Governments, Employers, and Workers of International Labour Office (ILO) member states. Originally designed to guard against the danger that 1 country or other would keep down wages and working conditions to gain competitive advantage and thereby undermine advances elsewhere, international labor standards have also been inspired by humanitarian concerns--the visible plight of workers and the physical dangers of industrialization and by the notion of social justice, which embraces wellbeing and dignity, security, and equality as well as a measure of participation in economic and social matters. ILO standards apply to workers generally and therefore also to migrant workers, irrespective of the fact that the general standards are complemented by standards especially for migrant workers. The social security protection of migrant workers has been dealt with in ILO instruments primarily from the angle of equality of treatment but also from that of the maintenance of acquired rights and rights in course of acquisition, including the payment of benefits to entitled persons resident abroad. The ILO Conventions on migrant workers and the Recommendations which supplement them deal with practically all aspects of the work and life of non-nationals such as recruitment matters, information to be made available, contract conditions, medical examination and attention, customs, exemption for personal effects, assistance in settling into their new environment, vocational training, promotion at work, job security and alternative employment, liberty of movement, participation in the cultural life of the state as well as maintenance of their own culture, transfer of earnings and savings, family reunification and visits, appeal against unjustified termination of employment or expulsion, and return assistance. ILO's supervisory

The internal consistency of the standard gamble: tests after adjusting for prospect theory.

Science.gov (United States)

Oliver, Adam

2003-07-01

This article reports a study that tests whether the internal consistency of the standard gamble can be improved upon by incorporating loss weighting and probability transformation parameters in the standard gamble valuation procedure. Five alternatives to the standard EU formulation are considered: (1) probability transformation within an EU framework; and, within a prospect theory framework, (2) loss weighting and full probability transformation, (3) no loss weighting and full probability transformation, (4) loss weighting and no probability transformation, and (5) loss weighting and partial probability transformation. Of the five alternatives, only the prospect theory formulation with loss weighting and no probability transformation offers an improvement in internal consistency over the standard EU valuation procedure.

Book of abstracts of the 3rd International conference and the 3rd International School for young scientists Interaction of hydrogen isotopes with structural materials. IHISM-07; Tezisy dokladov Tret'ej mezhdunarodnoj konferentsii i Tret'ej mezhdunarodnoj Shkoly molodykh uchenykh i spetsialistov Vzaimodejstvie izotopov vodoroda s konstruktsionnymi materialami. IHISM-07

Energy Technology Data Exchange (ETDEWEB)

NONE

2007-07-01

The book involves abstracts of presentations at the 3rd International Conference and the 3rd International School for Young Scientists Interaction of Hydrogen Isotopes with Structural Materials (IHISM-07). The activities of Russian and foreign scientific centers associated with the use of hydrogen isotopes in power engineering, national economy and basic research are considered. The presentations cover the following areas: kinetics and interaction between hydrogen isotopes and solids including effects of radiogenic helium accumulation, hydrides and hydride transformations; structural transformations and mechanical properties; equipment and research techniques.

International standards for financial reporting: Harmonization in Macedonia

OpenAIRE

Kozuharov, Sasho; Ristovska, Natasha; Blazeska, Daliborka

2015-01-01

A continuous flow of reliable, relevant and financially important information is necessary for making economically justified and strategic investment decisions. Economic globalization has contributed to the need of creating a unified language for communication, a single set of international financial reporting standards with the sole purpose of enhancing transparency for investors and reducing the cost of capital. Harmonization of financial reporting provides more efficient use of...

The international standard for protection from ionizing radiation and safety of radiation sources

Energy Technology Data Exchange (ETDEWEB)

Schlesinger, T [Israel Atomic Energy Commission, Yavne (Israel). Soreq Nuclear Research Center

1995-06-01

This document is a review in hebrew of the new 1994 international standard of the IAEA. The new standard title is `Basic safety standards for radiation protection and for the safety of radiation sources`, which were published in the ICRP Pub. 9.

Intracellular Cadmium Isotope Fractionation

Science.gov (United States)

Horner, T. J.; Lee, R. B.; Henderson, G. M.; Rickaby, R. E.

2011-12-01

Recent stable isotope studies into the biological utilization of transition metals (e.g. Cu, Fe, Zn, Cd) suggest several stepwise cellular processes can fractionate isotopes in both culture and nature. However, the determination of fractionation factors is often unsatisfactory, as significant variability can exist - even between different organisms with the same cellular functions. Thus, it has not been possible to adequately understand the source and mechanisms of metal isotopic fractionation. In order to address this problem, we investigated the biological fractionation of Cd isotopes within genetically-modified bacteria (E. coli). There is currently only one known biological use or requirement of Cd, a Cd/Zn carbonic anhydrase (CdCA, from the marine diatom T. weissfloggii), which we introduce into the E. coli genome. We have also developed a cleaning procedure that allows for the treating of bacteria so as to study the isotopic composition of different cellular components. We find that whole cells always exhibit a preference for uptake of the lighter isotopes of Cd. Notably, whole cells appear to have a similar Cd isotopic composition regardless of the expression of CdCA within the E. coli. However, isotopic fractionation can occur within the genetically modified E. coli during Cd use, such that Cd bound in CdCA can display a distinct isotopic composition compared to the cell as a whole. Thus, the externally observed fractionation is independent of the internal uses of Cd, with the largest Cd isotope fractionation occurring during cross-membrane transport. A general implication of these experiments is that trace metal isotopic fractionation most likely reflects metal transport into biological cells (either actively or passively), rather than relating to expression of specific physiological function and genetic expression of different metalloenzymes.

Cultural impact on the harmonisation of Russian Accounting Standards with the International Financial Reporting Standards: A practitioner's perspective

OpenAIRE

Combs, A; Samy, M; Myachina, A

2013-01-01

Purpose\\ud – The purpose of this paper is to explore cultural impact on the harmonisation of Russian Accounting Standards with International Financial Reporting Standards (IFRS).\\ud \\ud Design/methodology/approach\\ud – A theoretical review established that differences still exist between the two sets of accounting standards. For decades, Russia was a socialist state of planned economy. Accounting was a tool of centralised control, and accountants had a job of gathering information for statist...

The European Union CREATE project: a model for international standardization of allergy diagnostics and vaccines

NARCIS (Netherlands)

Chapman, Martin D.; Ferreira, Fatima; Villalba, Mayte; Cromwell, Oliver; Bryan, Donna; Becker, Wolf-Meinhard; Fernández-Rivas, Montserrat; Durham, Stephen; Vieths, Stefan; van Ree, Ronald; Aalbers, M.; Notten, S.; Ooievaar-de Heer, P.; Ferreira, F.; Gademaier, G.; Wallner, M.; Villalba, M.; Rodriguez, R.; Becker, W.-M.; Eberhardt, F.; Lepp, U.; Raulf-Heimsoth, M.; Valenta, R.; Focke, M.; Bryan, D.; Dolman, C.; Das, R. G.; Vieths, S.; Fötisch, K.; Di Felice, G.; Pini, C.; Cromwell, O.; Fiebig, H.; Weber, B.; van Schijndel, H.; Dorpema, J. W.; Marco, F. M.; Monsalve, R.; Barber, D.; Caldas, E. Fernandez; Moingeon, P.; Didierlaurent, A.; André, C.; Kroon, A.; Neubauer, A.; Chapman, M.; Vailes, L.; Tsay, A.; Durham, S.; Custovic, A.; Simpson, B.; Knulst, A.; Rivas, M. Fernández; Mancebo, E. Gonzalez; Bahima, A. Cistero; Moncin, M. M. San Miguel; Mari, A.; Kinaciyan, T.; Quiralte, J.; Pauli, G.; de Blay, F.; Purohit, A.; Rak, S.

2008-01-01

Allergen measurements are used extensively in the formulation of allergy diagnostics and vaccines, yet no purified international allergen standards are available for calibration purposes. The aims of the European Union CREATE project were to develop international standards with verifiable allergen

The developments of international hydrogen and fuel cell technology standards and the response strategies in Taiwan

International Nuclear Information System (INIS)

Tso, C.

2009-01-01

The application of hydrogen and fuel cells has expanded as the technology in international markets has improved. Leading countries have focused on establishing hydrogen and fuel cell technology standards. Both the International Organization for Standardization (ISO) and the International Electrotechnical Commission (IEC) continuously release new hydrogen and fuel cell related standards. Although the government of Taiwan is promoting the development of a hydrogen and fuel cell industry, it may delay the commercialized schedule if there are no hydrogen and fuel cell related standards and regulations in place. Standards and regulations must be established as quickly as possible in order to accelerate the progress of the hydrogen and fuel cell industry. This presentation reviewed the international progress in hydrogen and fuel cell development and explained Taiwan's response strategies regarding the adoption of hydrogen and fuel cell products in niche Taiwanese markets

Language standardization in sociolinguistics and international business: Theory and practice across the table

DEFF Research Database (Denmark)

Linn, Andrew; Sanden, Guro Refsum; Piekkari, Rebecca

2018-01-01

Haugen to explain the history of modern Norwegian. The table is then turned and a model from international business by Piekkari, Welch and Welch is used to illuminate recent Norwegian language planning. It is found that the Grundfos case works well with the Haugen model, and the international business...... model provides a valuable practical lesson for national language planners, both showing that a “comparative standardology” is a valuable undertaking. More voices “at the table” will allow both theory and practice to be further refined and for the role of standards across society to be better understood.......This chapter addresses the issue of language standardization from two perspectives, bringing together a theoretical perspective offered by the discipline of sociolinguistics with a practical example from international business. We introduce the broad concept of standardization and embed the study...

Amendments to the Audit Report for the Review of International Standards on Auditing

Directory of Open Access Journals (Sweden)

Mortură Laura-Alexandra

2017-01-01

Full Text Available As a result of the last economic and financial crisis, the auditors' impact on its triggering wasquestioned, as the opinion expressed by the auditors directly influenced, the decisions taken by theusers of the financial and accounting information, namely the investors. The sign of question on theauditors 'work was also due to a lack of knowledge of the auditors' responsibility by the users. Theopinion issued by the auditor provides reasonable, but not absolute, assurance on the informationprovided by the financial statements, in which case the auditor's responsibility is limited. Tomitigate these discrepancies, the International Auditing and Assurance Standards Board (IAASBhas developed projects that have generated solutions to improve International Standards onAuditing. Thus, in 2015, the IAASB issued a new edition of the International Auditing Standards,which made changes in the drafting of the audit report.

Internationally Standardized Cost Item Definitions for Decommissioning of Nuclear Installations

International Nuclear Information System (INIS)

Lucien Teunckens; Kurt Pflugrad; Candace Chan-Sands; Ted Lazo

2000-01-01

The European Commission (EC), the International Atomic Energy Agency (IAEA), and the Organization for Economic Cooperation and Development/Nuclear Energy Agency (OECD/NEA) have agreed to jointly prepare and publish a standardized list of cost items and related definitions for decommissioning projects. Such a standardized list would facilitate communication, promote uniformity, and avoid inconsistency or contradiction of results or conclusions of cost evaluations for decommissioning projects carried out for specific purposes by different groups. Additionally, a standardized structure would also be a useful tool for more effective cost management. This paper describes actual work and result thus far

Applying international standards and guidelines on corporate social responsibility: An action plan

NARCIS (Netherlands)

Cramer, J.M.

2005-01-01

How can a company start the process of corporate social responsibility in an international context, thereby makinge use of diverse standards and guidelines? This question immediately came to the fore emerged after the start of the programme ‘Corporate social responsibility in international context’

A routine high-precision method for Lu-Hf isotope geochemistry and chronology

Science.gov (United States)

Patchett, P.J.; Tatsumoto, M.

1981-01-01

A method for chemical separation of Lu and Hf from rock, meteorite and mineral samples is described, together with a much improved mass spectrometric running technique for Hf. This allows (i) geo- and cosmochronology using the176Lu???176Hf+??- decay scheme, and (ii) geochemical studies of planetary processes in the earth and moon. Chemical yields for the three-stage ion-exchange column procedure average 90% for Hf. Chemical blanks are international mass spectrometric standard; suitable aliquots, prepared from a single batch of JMC 475, are available from Denver. Lu-Hf analyses of the standard rocks BCR-1 and JB-1 are given. The potential of the Lu-Hf method in isotope geochemistry is assessed. ?? 1980 Springer-Verlag.

75 FR 75937 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2010-12-07

... National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines... internal combustion engines. Subsequently, the Administrator received two petitions for reconsideration... Any industry using a stationary 2211 Electric power reciprocating internal generation, combustion...

Isotopes in the Arctic atmospheric water cycle

Science.gov (United States)

Bonne, Jean-Louis; Werner, Martin; Meyer, Hanno; Kipfstuhl, Sepp; Rabe, Benjamin; Behrens, Melanie; Schönicke, Lutz; Steen Larsen, Hans Christian; Masson-Delmotte, Valérie

2016-04-01

The ISO-ARC project aims at documenting the Arctic atmospheric hydrological cycle, by assessing the imprint of the marine boundary conditions (e.g. temperature variations, circulation changes, or meltwater input) to the isotopic composition of the atmospheric water cycle (H218O and HDO) with a focus on North Atlantic and Arctic oceans. For this purpose, two continuous monitoring water vapour stable isotopes cavity ring-down spectrometers have been installed in July 2015: on-board the Polarstern research vessel and in the Siberian Lena delta Samoylov research station (N 72° 22', E 126° 29'). The Polarstern measurements cover the summer 2015 Arctic campaign from July to mid-October, including six weeks in the Fram Strait region in July- August, followed by a campaign reaching the North Pole and a transect from the Norwegian Sea to the North Sea. These vapour observations are completed by water isotopic measurements in samples from the surface ocean water for Polarstern and from precipitation in Samoylov and Tiksi (120 km south-east of the station). A custom-made designed automatic calibration system has been implemented in a comparable manner for both vapour instruments, based on the injection of different liquid water standards, which are completely vaporised in dry air at high temperature. Subsequent humidity level can be adjusted from 2000 to at least 30000 ppm. For a better resilience, an independent calibration system has been added on the Samoylov instrument, allowing measurements of one standard at humidity levels ranging from 2000 to 15000 ppm: dry air is introduced in a tank containing a large amount of liquid water standard, undergoing evaporation under a controlled environment. The measurement protocol includes an automatic calibration every 25 hours. First instrument characterisation experiments depict a significant isotope-humidity effect at low humidity, dependant on the isotopic composition of the standard. For ambient air, our first isotope

METHODOLOGICAL ASPECTS OF CONTENT ANALYSIS OF CONVERGENCE BETWEEN UKRAINIAN GAAP AND INTERNATIONAL FINANCIAL REPORTING STANDARDS

Directory of Open Access Journals (Sweden)

R. Kuzina

2015-06-01

Full Text Available The objective conditions of Ukraine’s integration into the global business environment the need to strengthen the accounting and financial re-porting. At the stage of attracting investment in the country there is a need in the preparation of financial statements generally accepted basic prin-ciples of which are based on common international financial reporting standards (IFRS . Relevant is the assessment of convergence of national standards and International Financial Reporting Standards. However, before you conduct content analysis necessary to determine compliance with standards of methodological approaches to the selection of key indicators for the assessment of convergence. The article is to define the methodo-logical approaches to the selection and development of indicators IFRSs list of key elements for further evaluation convergence of national and international standards. To assess the convergence was allocated 187 basic key elements measuring the level of convergence to IFRS. Sampling was carried out based on the professional judgment of the author, the key indicators of the standard, based on the evaluation of the usefulness of accounting information. These figures make it possible to calculate the specific level of convergence of international and national standards and determine how statements prepared by domestic standards corresponding to IFRS. In other words, can with some certainty assert that Ukraine has made (“good practices in IFRS implementation” or not? This calculation will assess the regulatory efforts of government agencies (Ministry of Finance on the approximation of Ukrainian standards and IFRS.

Housekeeping Genes as Internal Standards: Use and Limits

OpenAIRE

Thellin, Olivier; Zorzi, Willy; Lakaye, Bernard; De Borman, B.; Coumans, Bernard; Hennen, Georges; Grisar, Thierry; Igout, Ahmed; Heinen, Ernst

1999-01-01

Quantitative studies are commonly realised in the biomedical research to compare RNA expression in different experimental or clinical conditions. These quantifications are performed through their comparison to the expression of the housekeeping gene transcripts like glyceraldehyde-3-phosphate dehydrogenase (G3PDH), albumin, actins, tubulins, cyclophilin, hypoxantine phsophoribosyltransferase (HRPT), L32. 28S, and 18S rRNAs are also used as internal standards. In this paper, it is recalled tha...

International Standards for Radiation Sterilization of Medical Devices

International Nuclear Information System (INIS)

Miller, A.

2007-01-01

For a terminally sterilized medical device to be designated '' STERILE '', probability of finding the viable micro-organisms in the device shall be equal to or less than 1 x 10 -6 (EN 556-1:2001: Sterilization of medical devices - Requirements for medical devices to be designated '' STERILE '' - Part 1: Requirements for terminally sterilized medical devices). Author presents the main legal aspects of the international standards for radiation sterilization of medical devices

International standards for the exploration and production industry -- Their development and use

International Nuclear Information System (INIS)

Johansen, A.R.; Loppinet, A.; Reeve, P.T.N.; Thomas, G.A.N.; Thorp, G.; Vanzini, R.

1995-01-01

A single global market for procurement is of crucial importance to the E and P industry. The resulting benefits, including cost reductions and shorter delivery times, could even be the key to the economic development of marginal fields. International Standards that cater for the needs of users, manufacturers and the public at large can provide a common basis for companies to procure and provide goods and services that will deliver the required performance throughout the field life. The savings to industry could be billions of dollars per year. The E and P Forum, on behalf of the industry, has developed proposals to increase the efficiency of this managerial procedure and to speed up the ''internationalization'' of selected standards. Details are given at the end of the paper. It is argued that the E and P industry should rally to the cause of international standardization. Companies should lend their full support by committing their valuable expert resources. It is in the interests of the industry to do this for, without suitably skilled expert representation in ISO and the elimination of duplication as well as waste of resources through performing similar work at company or national level, the large potential benefits of international standardization will elude the E and P industry

Traceability system for radioactivity standards in Japan

International Nuclear Information System (INIS)

Hino, Yoshio

2000-01-01

The electrotechnical laboratory (ETL) is the one of the largest national research institute, affiliated with the Ministry of International Trade and Industry (MITI). The ETL has a role to maintain the national standards of electricity, acoustics, visible light, ionizing radiation and radioactivity. The primary radioactivity standards have been established in ETL mainly with the 4πβ-γ coincidence method. The liquid scintillation counters and multi-wire proportional counters are also used for pure-beta and surface emission rate standards, respectively. As for the traceability, the primary standard sources are transferred to the Japan Radio Isotope Association (JRIA), and the JRIA measure these sources to calibrate their secondary standard equipments such as high pressurized 4π ionization chambers, high pore Ge and Nal (Tl) gamma spectrometers. The primary sources are also sent to the BIPM and neighboring countries for the intercomparisons to keep the consistency of the national standards. In this paper, these measurement techniques for the primary standardization and transfer system will be introduced, and some results of comparisons for certificate the traceability system will be described. (author)

Draft I.E.C. standard for monitoring PWR internal structures; Projet de norme C.E.I. pour la surveillance des structures internes des REP

Energy Technology Data Exchange (ETDEWEB)

Trenty, A.

1994-06-01

EDF has proposed to the International Electrotechnical Commission a draft standard for monitoring the vessel internal structures of PWRs. The standard applies to systems used for monitoring the vibratory behavior of the internal structures of PWRs (core barrel, thermal shield, fuel assemblies) on the basis of neutron fluctuations observed outside the vessel as well as of vessel vibrations. It covers the systems characteristics and the monitoring procedures. It should facilitate standardization of monitoring and comparisons on an international level. This paper presents the main features of the draft standard: -principles of measurement: correlation between movements of internals and ex core neutron noise on the one hand, forced vibrations of the vessel on the other hand; -sampling and conditioning of the signals; -monitoring equipment and in particular spectral analysis device; -functions of the monitoring software used for spectral analysis, peak detection and calculation of structure displacement; -studies preliminary to setting up the monitoring (calculation of internal vibratory modes, defect simulation on mockup, qualification on reactor during hot test...); -monitoring procedures (periodicity of analysis and what to do in case of anomaly); -documentation necessary to the monitoring. A diagnostic procedure is given as an example. The draft standard, written in 1994, will be presented in Frankfurt (Germany) in February 1995. (author). 1 annexe.

Uncertainties achievable for uranium isotope-amount ratios. Estimates based on the precision and accuracy of recent characterization measurements

International Nuclear Information System (INIS)

Mathew, K.J.; Essex, R.M.; Gradle, C.; Narayanan, U.

2015-01-01

Certified reference materials (CRMs) recently characterized by the NBL for isotope-amount ratios are: (i) CRM 112-A, Uranium (normal) Metal Assay and Isotopic Standard, (ii) CRM 115, Uranium (depleted) Metal Assay and Isotopic Standard, and (iii) CRM 116-A, Uranium (enriched) Metal Assay and Isotopic Standard. NBL also completed re-characterization of the isotope-amount ratios in CRM 125-A, Uranium (UO 2 ) Pellet Assay, Isotopic, and Radio-chronometric Standard. Three different TIMS analytical techniques were employed for the characterization analyses. The total evaporation technique was used for the major isotope-amount ratio measurement, the modified total evaporation technique was used for both the major and minor isotope-amount ratios, and minor isotope-amount ratios were also measured using a Conventional technique. Uncertainties for the characterization studies were calculated from the combined TIMS data sets following the ISO Guide to the expression of uncertainty in measurement. The uncertainty components for the isotope-amount ratio values are discussed. (author)

COMPETITIVE ADVANTAGES THROUGH THE IMPLEMENTATION OF INTERNATIONAL ENERGY MANAGEMENT STANDARDS

Directory of Open Access Journals (Sweden)

PALIEKHOVA L. L.

2016-03-01

Full Text Available Purpose. The purpose of the presented research is to explore the potential of international energy management standards to increase competitiveness of industrial enterprises under conditions of Ukrainian transitional economy. The study had the following objectives: to trace the evolution of fundamental energy efficiency standards; to discuss experience in their use in various countries; to identify factors that are key to achieving competitive advantage under the implementation ISO 50001. Methodology. This article presents a historical overview of the standardisation of principles and approaches for the purpose of the energy-efficient management. The research was carried out by studying the international documents, voluntary standards and national practices in the field of energy efficiency. Conclusions. The study examines the experiences of different countries in the field of energy management systems. The authors conducted a comparative analysis of the ISO 50001 with the other basic standards for the organisation of management. The system approach enables to identify the main factors and their impact on capacity to achieve competitive advantages, which are possible to obtain after certification to ISO 50001. Originality. The study reviewed and analysed the energy management penetration within its dynamics at time and country level. After analysing the statistical data and the results of the interviews, the authors identified 20 key factors affecting the competitiveness of enterprises that are certified to ISO 50001. All of these factors were divided into four groups, two groups represent external environment – opportunities and threats, and two groups – internal capacity – strengths and weaknesses of enterprises. Practical value. The proposed system of factors may be useful for the planning of actions towards strengthening the capacity of energy management systems in the context of the formation competitive advantages on the industrial

76 FR 12923 - National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion...

Science.gov (United States)

2011-03-09

... National Emission Standards for Hazardous Air Pollutants for Reciprocating Internal Combustion Engines... pollutants for existing stationary spark ignition reciprocating internal combustion engines. The final rule... reciprocating internal combustion generation, engine. transmission, or distribution. 622110 Medical and surgical...

ANALYSIS OF THE IMPLEMENTATION OF INTERNATIONAL FINANCIAL REPORTING STANDARDS BY COUNTRIES WITH ECONOMIES IN TRANSITION

Directory of Open Access Journals (Sweden)

B. Zasadnyi

2013-08-01

Full Text Available The article deals with experience of application of international financial reporting standards in different countries with economies in transition. The main advantages and disadvantages of the implementation of international financial reporting standards for financial reporting for Ukrainian companies are based on this experience.

High precision analysis of trace lithium isotope by thermal ionization mass spectrometry

International Nuclear Information System (INIS)

Tang Lei; Liu Xuemei; Long Kaiming; Liu Zhao; Yang Tianli

2010-01-01

High precision analysis method of ng lithium by thermal ionization mass spectrometry is developed. By double-filament measurement,phosphine acid ion enhancer and sample pre-baking technique,the precision of trace lithium analysis is improved. For 100 ng lithium isotope standard sample, relative standard deviation is better than 0.086%; for 10 ng lithium isotope standard sample, relative standard deviation is better than 0.90%. (authors)

Isotopic compositions of the elements 2013 (IUPAC Technical Report)

Science.gov (United States)

Meija, Juris; Coplen, Tyler B.; Berglund, Michael; Brand, Willi A.; De Bièvre, Paul; Gröning, Manfred; Holden, Norman E.; Irrgeher, Johanna; Loss, Robert D.; Walczyk, Thomas; Prohaska, Thomas

2016-01-01

The Commission on Isotopic Abundances and Atomic Weights (ciaaw.org) of the International Union of Pure and Applied Chemistry (iupac.org) has revised the Table of Isotopic Compositions of the Elements (TICE). The update involved a critical evaluation of the recent published literature. The new TICE 2013 includes evaluated data from the “best measurement” of the isotopic abundances in a single sample, along with a set of representative isotopic abundances and uncertainties that accommodate known variations in normal terrestrial materials.

International training workshop on quality control and management of food irradiation

International Nuclear Information System (INIS)

2004-01-01

The International Training Workshop on Quality Control and Management of Food Indantrione was hold from 28-30, August, 2004 in Beijing, China and organized by Chinese Society of Nuclear Agriculture and China Isotope and Radiation Association. 10 Articles were collected in this symposium including training lectures. The contents included: international developments in food irradiation, Quality control and magement of food irradiation, industrializing development of irradiated food in China, Food irradiator and its quality management, research in setting standard for enterprise about irradiated products and etc.

Isotopic Determination of Region of Origin in Modern Peoples: Applications for Identification of U.S. War-Dead From the Vietnam Conflict

Science.gov (United States)

2006-08-01

contribution of gluconeogenesis to glucose production in humans. Here, body water was enriched with 2H2O and the ratio of 2H bound to carbon-5 versus carbon-2...corn increased, but corn-based snacks such as popcorn, chips, and sodas/colas sweetened with high- fructose corn syrup are essentially a staple of...hydrogen, the internationally accepted standard of standard mean ocean water (SMOW or V-SMOW) is used (Hoefs 2004). The heavy isotopes of strontium and

Review of international standards related to the design for control rooms on nuclear power plants

International Nuclear Information System (INIS)

Kitamura, Masashi; Yoshikawa, Hidekazu; Fujita, Yushi

2005-01-01

The improvement of Human-Machine Interface (HMI) design for control rooms on nuclear power plants (NPP) has been accomplished world wide, especially after the TMI-2 accident. The design process and guidelines are standardized in IEC60964 and supplemental standards as international standard. However, technological update is required due to the increased use of computerized control and monitoring equipment and systems in control rooms on NPP in recent years. Standards are becoming more important for computerized control rooms because there is more freedom to design than conventional hardware based system. For computerized control rooms, standards for hardware and software of HMI systems should be also considered. Standards and guidelines for computerized control rooms on NPP have been developed recently in each body such as IEC, ISO, and IEEE etc. Therefore, reviewing these standards and guidelines related to control rooms design of NPP can be useful not only for revision of the international standards such as IEC60964, but also for users of the standards and guidelines. In this paper, we reviewed the international standards related to the design for control rooms, in the two aspects of HMI design and hardware and software design, considering the undergoing revision work and their application. (author)

International standardization of instruments for neutron irradiation tests

International Nuclear Information System (INIS)

Tanimoto, Masataka; Shibata, Akira; Nakamura, Jinichi; Tsuchiya, Kunihiko; Cho, M.; Lee, C.; Park, S.; Choo, K.

2012-01-01

The JMTR in JAEA and HANARO in KAERI are the foremost testing/research reactors in the world and these are expected to contribute to many nuclear fields. As a part of instrument development in irradiation field, information exchange of instruments started from 2010 under the cooperation agreements between KAERI and JAEA. The instruments developed in JMTR and HANARO are introduced and cooperation experiments as future plan are discussed for international standardization. (author)

Isotopic methods in hydrogeology and their application to the Underground Research Laboratory, Manitoba

International Nuclear Information System (INIS)

Gascoyne, M.; Kotzer, T.

1995-09-01

This review examines isotopic methods used to determine groundwater sources, residence times and processes of geochemical evolution that have been published in the international literature, with specific reference to AECL's experience in these methods and applications to groundwaters at the Underground Research Laboratory (URL), Manitoba. The program of groundwater sampling and analysis currently being planned for the URL area over the next several years will concentrate on specific isotopic measurements that may assist in understanding the groundwater flow system at the URL site. These results will add to the existing data for the URL area and indicate which isotopes are most useful when applied to the known groundwater flow system of the URL. This program of study is especially important because it not only uses standard geochemical and isotopic measurements (e.g., major ion, trace elements, 2 H/ 18 O, 14 C, 34 S) of groundwaters, but will determine values of more exotic and unusual ratios, such as 6 Li/ 7 Li, and B 11 /B 10 , whose potential for understanding groundwater geochemical evolution is largely unknown at present. In addition, the more established but equally complex methods of isotopic analysis, to determine 3 He/ 4 He, 36 Cl/Cl and 129 I/I, will be used to assess their potential for adding to the hydrogeochemical understanding of flow paths in crystalline rock. (author). 182 refs., 11 tabs., 27 figs

Intemational collaborative study on the preparation of 1st international standard for rhTSH for bioassay

International Nuclear Information System (INIS)

Huang Ying; Shen Hongzheng; Yu Ting; Xu Ligen

2007-01-01

The history of the international collaborative studies on the preparation of standards of TSH for bioassay and immunoassay was reviewed. The result of collaborative study on the 1st international standard for thyroid-stimulating hormone, recombinant, human, for bioassay was reported in detail in this article. Based on the results of this collaborative study, it is proposed that the candidate standard be established as the international standard for rhTSH for bioassay, and be assigned an activity of 9.5 IU per ampoule. The national standard preparation of TSH for immunoassay was also reassayed, revealing the potency to be 0.557 mIU/ampoule, i.e. 92. 8% of the labelled value of 0.600mIU/ampoule, a reasonable consistency. (authors)

The protection of the accused in international criminal law according to the Human Rights Law Standard

Directory of Open Access Journals (Sweden)

Karolina Kremens

2011-12-01

Full Text Available The presented paper discusses the influence of international human rights law on international criminal law. It tries to give an answer to the question of whether rules protecting the accused in international criminal proceedings meet the human rights law standard provided by international declarations and covenants. Meaning, if the proceedings before the International Criminal Tribunal for Former Yugoslavia (ICTY, International Criminal Tribunal for Rwanda (ICTR and International Criminal Court (ICC meet the standard provided by international human rights law, in particular the International Covenant on Civil and Political Rights. The paper proves that international human rights law has affected international criminal law tremendously. Moreover, it is argued that the protection of the accused in the law of the international courts and tribunals with regard to his rights has improved when compared to the international human rights law standard. In particular the Rome Statute of the ICC provides the accused with the most comprehensive protection. This is especially visible in the case of such rights as the presumption of innocence, right to an interpreter and right to remain silent. Nevertheless, some shortcomings in the law of the ad hoc tribunals and ICC can be observed, in particular when it comes to identifying the commencement of protection of the accused.

Fiscal 1999 technical research report. Development project on prompt-effect international standards for developing new industry (Comprehensive survey and research concerning promotion of international standardization); 1999 nendo shinki sangyo ikusei sokkogata kokusai hyojun kaihatsu jigyo seika hokokusho. Kokusai hyojunka suishin ni kakawaru sogo chosa kenkyu

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

For encouraging the promotion of international standardization involving the six subjects of advanced technology taken up under the above-named project, wide-range investigations are conducted into measures for international standardization, the activities of international standardizing agencies and organizations, and the approaches of European and American business corporations to this issue. Technical literature and material are studied in Japan, and interviews are held overseas with responsible persons at organizations and corporations engaged in this task. At Standards Development Organization (SDO) of America, verification tests are under way for early development into international standards of technical standards it has so far developed independently. For the strategical utilization of intellectual property incorporated into its technical standards, SDO accepts that the best policy is to win approvals from patent proprietors at the early stage of standardization process by presenting them with conditions about patent implementation. In Europe and America, for the enhancement of their competitive power in the international theater, governments and civil sectors cooperate with each other for the establishment of international standards and, in business corporations, the management takes the initiative in coping with the issue with an understanding that there are business opportunities in international standardization. (NEDO)

Measurement of organic carbon stable isotope composition of different soil types by EA-IRMS system

International Nuclear Information System (INIS)

Qi Biao; Ding Lingling; Cui Jiehua; Wang Yanhong

2009-01-01

Element analyzer-isotope ratio mass spectrometers (EA-IRMS) is a rapid and precise method for measuring stable carbon isotope. Pure CO 2 reference gas was calibrated via international standard-Urea, and the δ 13 C us PDB value of pure CO 2 is (-29.523 ± 0.0181)%. Stability and linearity of the EA-IRMS system, precision of δ 13 C measurement for samples were tested through experimental comparison. Moreover, determination method of organic carbon stable isotope in soil was based on the system. The EA-IRMS system had well linearity when ion intensity ranged from 1.0 to 7.0V, and it excelled the total linearity when the ion intensity was from 1.5 to 5.0V, and the accurate result of δ 13 C for sample analysis could be obtained with precision of 0.015%. If carbon content in sample is more than 5μg, the requirement for analyzing accurate result of δ 13 C could be achieved. The organic carbon stable isotope was measured in 18 different types soil samples, the average natural abundance of 13 C was 1.082%, and the organic carbon stable isotope composition was significantly different among different type soils. (authors)

Isotopic Changes During Digestion: Protein

Science.gov (United States)

Tuross, N.

2013-12-01

Nutrient and hydrological inputs traverse a complicated route of pH, enzymatic and cellular processes in digestion in higher animals. The end products of digestion are the starting products for biosynthesis that are often used to interpret past life-ways. Using an artificial gut system, the isotopic changes (dD, d18O, d13C and d15N) of protein are documented. Three separate protein sources are subjected to the conditions, chemical and enzymatic, found in the stomach and upper small intestine with only a small shift in the oxygen isotopic composition of the proteins observed. Middle to lower small intestine parameters produced both greater isotopic effects and significantly lower molecular weight products. The role of the gastric enterocyte and the likely involvement of the internal milieu of this cell in the isotopic composition of amino acids that are transported to the liver are reported.

Problems of the development of international standards of “green building” in Russia

Science.gov (United States)

Meshcheryakova, Tatiana

2017-10-01

Problems of environmental friendliness and energy efficiency in recent decades have become not only the most important issues of economic development of the main industrial economies, but also the basis for the processes of maintaining the security and relative stability of the global ecosystem. The article presents the results of the study of the status and trends of the development of environmental standards for the construction and maintenance of real estate in the world and particularly in Russia. Special market instruments for assessing the compliance with the quality of real estate projects under construction and modern principles of environmental friendliness and energy efficiency include voluntary building certification systems that are actively used in international practice. In Russia there is active use of the following international systems of certification: BREEAM, LEED, DGNB, HQE. Also in the Russian certification market, the national standard STO NOSTROY 2.35.4-2011 “Residential and public buildings” is being implemented, which summarizes the best international experience of the rating evaluation procedure. Comparative characteristics of the “green” standards and the principles of rating assessments of the ecological compatibility of buildings give an idea of applying these standards in Russia.

Concrete blocks. Analysis of UNE, ISO en standards and comparison with other international standards

Directory of Open Access Journals (Sweden)

Álvarez Alonso, Marina

1990-12-01

Full Text Available This paper attempts to describe the recently approved UNE standards through a systematic analysis of the main specifications therein contained and the values considered for each of them, as well as the drafts for ISO and EN concrete block standards. Furthermore, the study tries to place the set of ISO standards in the international environment through a comparative analysis against a representative sample of the standards prevailing in various geographical regions of the globe to determine the analogies and differences among them. PALABRAS CLAVE: albañilería, análisis de sistemas, bloque de hormigón, muros de fábrica, normativa KEY WORDS: masonry, system analysis, concrete blocks, masonry walls, standards

En este trabajo se pretende describir la reciente aprobada normativa UNE, analizando sistemáticamente las principales prescripciones contempladas y los valores considerados para cada una de ellas, así como los proyectos de Norma ISO, y EN sobre bloques de hormigón. Asimismo se intenta situar la normativa UNE en al ámbito internacional, haciendo un análisis comparativo con una representación de Normas de distintas regiones geográficas del mundo, determinando sus analogías y diferencias.

International Cooperation to Establish Standard Operating Procedure (SOP) for Quarantine Management of Irradiated Foods in International Trade

International Nuclear Information System (INIS)

Lee, J. W.; Byun, M. W.; Kim, J. H.; Choi, J. I.; Song, B. S.; Yoon, Y. H.; Kim, D. H.; Kim, W. G.; Kim, K. P.

2010-02-01

· Development of SOPs through various research activities such as building international cooperation, and analysing current status of food irradiation in domestic and international markets, export and import, international market size, and of R and D - Analysis of examples for quarantine management in agricultural product exporting countries and use of irradiation technology for agricultural product quarantine, and changes in international quarantine management - Analysis of SOPs for food irradiation quarantine in international organization (CODEX, IPPC, WHO). U.S, EU, China, India, and Australia. - Collaborative researches of India/Korea and China/Korea entered into an agreement for market trials · Publishment of irradiation quarantine management SOPs agreed to CODEX standards - Collaborative researches for quarantine management, avoiding Technical Barrier to Trade (TBT), and Sanitary Phytosanitary Measures were conducted, and advanced SOPs agreed with WTO/FTA system were published

Determination of zinc stable isotopes in biological materials using isotope dilution inductively coupled plasma mass spectrometry

International Nuclear Information System (INIS)

Patterson, K.Y.; Veillon, Claude

1992-01-01

A method is described for using isotope dilution to determine both the amount of natural zinc and enriched isotopes of zinc in biological samples. Isotope dilution inductively coupled plasma mass spectrometry offers a way to quantify not only the natural zinc found in a sample but also the enriched isotope tracers of zinc. Accurate values for the enriched isotopes and natural zinc are obtained by adjusting the mass count rate data for measurable instrumental biases. Analytical interferences from the matrix are avoided by extracting the zinc from the sample matrix using diethylammonium diethyldithiocarbamate. The extraction technique separates the zinc from elements which form interfering molecular ions at the same nominal masses as the zinc isotopes. Accuracy of the method is verified using standard reference materials. The detection limit is 0.06 μg Zn per sample. Precision of the abundance ratios range from 0.3-0.8%. R.S.D. for natural zinc concentrations is about 200-600 μg g -1 . The accuracy and precision of the measurements make it possible to follow enriched isotopic tracers of zinc in biological samples in metabolic tracer studies. (author). 19 refs.; 1 fig., 4 tabs

Isotope production

Energy Technology Data Exchange (ETDEWEB)

Lewis, Dewi M.

1995-07-15

Some 2 0% of patients using radiopharmaceuticals receive injections of materials produced by cyclotrons. There are over 200 cyclotrons worldwide; around 35 are operated by commercial companies solely for the production of radio-pharmaceuticals with another 25 accelerators producing medically useful isotopes. These neutron-deficient isotopes are usually produced by proton bombardment. All commonly used medical isotopes can be generated by 'compact' cyclotrons with energies up to 40 MeV and beam intensities in the range 50 to 400 microamps. Specially designed target systems contain gram-quantities of highly enriched stable isotopes as starting materials. The targets can accommodate the high power densities of the proton beams and are designed for automated remote handling. The complete manufacturing cycle includes large-scale target production, isotope generation by cyclotron beam bombardment, radio-chemical extraction, pharmaceutical dispensing, raw material recovery, and labelling/packaging prior to the rapid delivery of these short-lived products. All these manufacturing steps adhere to the pharmaceutical industry standards of Good Manufacturing Practice (GMP). Unlike research accelerators, commercial cyclotrons are customized 'compact' machines usually supplied by specialist companies such as IBA (Belgium), EBCO (Canada) or Scanditronix (Sweden). The design criteria for these commercial cyclotrons are - small magnet dimensions, power-efficient operation of magnet and radiofrequency systems, high intensity extracted proton beams, well defined beam size and automated computer control. Performance requirements include rapid startup and shutdown, high reliability to support the daily production of short-lived isotopes and low maintenance to minimize the radiation dose to personnel. In 1987 a major step forward in meeting these exacting industrial requirements came when IBA, together with the University of Louvain-La-Neuve in Belgium, developed the Cyclone-30

Compilation of the Dakota Aquifer Project isotope data and publications: The Isotope Hydrology Program of the Isotope Sciences Division

International Nuclear Information System (INIS)

Davisson, M.L.; Smith, D.K.; Hudson, G.B.; Niemeyer, S.; Macfarlane, P.A.; Whittemore, D.O.

1995-01-01

In FY92 the then Nuclear Chemistry Division embarked on a scientific collaboration with the Kansas Geological Survey (KGS) to characterize with isotope techniques groundwater of the Dakota Formation of Kansas. The Dakota Formation is a Cretaceous-aged marine sandstone hosting potable groundwater in most regions of Kansas whose use will serve to partially offset the severe overdraft problems in the overlying Ogallala Formation. The isotope characterization of the Dakota groundwater has generated data that delineates sources, ages, and subsurface controls on the water quality. Initial interpretations of the data have been published in abstract volumes of (1) the 1993 Geological Society of America National Meeting, (2) the 8th International Conference on Geochronology, Cosmochronology and Isotope Geology, and (3) the 1994 Dakota Aquifer Workshop and Clinic. Copies of all abstracts are included in this brief review. One report will focus on the sources and ages of the groundwater, and the other will focus on the subsurface controls on the natural water quality

The first steps of isotope hydrology

International Nuclear Information System (INIS)

Moser, H.

1995-01-01

The author narrated on his personal experience of the past forty years of the development of isotope hydrology as an independent scientific branch. He started with the basic research work of for example Dansgaard and Libby and went on to the recent world-wide recording and interpreting isotopic data network. The IAEA organisation has accompanied the scientific development in an exemplary manner and, thus brought forward the isotope hydrological research activities to the high standard reached presently. This is documented by the great number of publications promoted by the IAEA throughout this time. 4 figs, 24 refs

Measurement of rimantadine in plasma by capillary gas chromatography/mass spectrometry with a deuterium-labeled internal standard

International Nuclear Information System (INIS)

Herold, D.A.; Anonick, P.K.; Kinter, M.; Hayden, F.G.

1988-01-01

Rimantadine is a synthetic antiviral agent used in prophylaxis and in treating the early stages of uncomplicated influenza A illness. We describe a stable isotope-dilution assay involving capillary gas chromatography/mass spectrometry. We used 200 ng of d3-rimantadine, added to 1 mL of plasma, as the internal standard. The rimantadine was extracted from the plasma with a Bond-Elut CN column, the column was washed with water, and the rimantadine was eluted with methanol, dried, and treated to form the t-butyldimethylsilyl derivative. The mass spectrometer was operated in the selected ion monitoring mode. Ions at m/z 236 and m/z 239 were monitored, corresponding to the loss of C4H9 from the rimantadine derivative and d3-rimantadine, respectively. Within-run precision (CVs) ranged from 8.9% at 29 micrograms/L to 3.2% at 1666 micrograms/L. Corresponding data for between-run precision were 5.4% and 1.7%. Treated volunteers (n = 86) provided plasma samples with a concentration range of 153 to 1127 micrograms/L. This simplified method allows rapid, precise assay of rimantadine in plasma

Adopting the international financial reporting standards: a positive impact on 2004 income and consolidated equity

International Nuclear Information System (INIS)

Mallet, O.

2005-03-01

This document provides preliminary information on the quantitative impact of transition to the International Financial Reporting Standards (IFRS) on AREVA 2004 financial position, in accordance with AMF recommendations regarding financial communications during the transition period.The basis for preparing 2004 information on transition to the IFRS comes from: the International Accounting Standards (IAS)/IFRS, as approved by the European Union. The impact of IAS 32/39 and IFRS 4 will not be recognized in shareholders equity until January 1, 2005; AREVA anticipation of the resolution of technical issues and ongoing projects under discussion by the International Accounting Standards Board (IASB) and the International Financial Reporting Interpretations Committee (IFRIC). Uncertainty factors on practical methods for applying certain standards and ongoing interpretations by IFRIC and regulatory organizations could impact the exactness of restatements identified at this stage. For all of these reasons, it is conceivable that the opening balance sheet at January 1, 2004, as presented in this document, will not be the balance sheet actually used to establish the consolidated financial statements for 2005. (author)

An apparatus for preparing isotopically pure He4

International Nuclear Information System (INIS)

McClintock, P.V.E.

1978-01-01

A cryostat has been constructed for extracting pure He 4 from He II of natural isotopic composition by means of a heat flush technique. It is shown that the method is in principle capable of yielding He 4 which is entirely devoid of He 3 isotopic impurities. A secondary heat flush, operated in conjunction with a conical heat exchanger of novel design, was used to place an experimental lower bound of 2 x 10 15 on the He 4 /He 3 ratio of the product, a standard sufficient for all present or projected applications requiring isotopically pure He 4 . The apparatus produces 2 000 1 (at standard temperature and pressure) of He 4 per thermal cycle. The design of future purifiers is discussed. (author)

Updating the International Standards for Tuberculosis Care. Entering the era of molecular diagnostics.

Science.gov (United States)

Hopewell, Philip C; Fair, Elizabeth L; Uplekar, Mukund

2014-03-01

The International Standards for Tuberculosis Care, first published in 2006 (Lancet Infect Dis 2006;6:710-725.) with a second edition in 2009 ( www.currytbcenter.ucsf.edu/international/istc_report ), was produced by an international coalition of organizations funded by the United States Agency for International Development. Development of the document was led jointly by the World Health Organization and the American Thoracic Society, with the aim of promoting engagement of all care providers, especially those in the private sector in low- and middle-income countries, in delivering high-quality services for tuberculosis. In keeping with World Health Organization recommendations regarding rapid molecular testing, as well as other pertinent new recommendations, the third edition of the Standards has been developed. After decades of dormancy, the technology available for tuberculosis care and control is now rapidly evolving. In particular, rapid molecular testing, using devices with excellent performance characteristics for detecting Mycobacterium tuberculosis and rifampin resistance, and that are practical and affordable for use in decentralized facilities in low-resource settings, is being widely deployed globally. Used appropriately, both within tuberculosis control programs and in private laboratories, these devices have the potential to revolutionize tuberculosis care and control, providing a confirmed diagnosis and a determination of rifampin resistance within a few hours, enabling appropriate treatment to be initiated promptly. Major changes have been made in the standards for diagnosis. Additional important changes include: emphasis on the recognition of groups at increased risk of tuberculosis; updating the standard on antiretroviral treatment in persons with tuberculosis and human immunodeficiency virus infection; and revising the standard on treating multiple drug-resistant tuberculosis.

Isotopes and Radiation in Entomology. Proceedings of a Symposium on the Use of Isotopes and Radiation in Entomology

Energy Technology Data Exchange (ETDEWEB)

NONE

1968-06-15

Proceedings of a Symposium jointly organized by the IAEA and the Food and Agriculture Organization of the United Nations and held in Vienna, 4-8 December 1967. The meeting was attended by 82 participants from 29 countries and six international organizations. Contents: Isotope applications - ecology (7 papers); Radiation effect studies - non-genetic (8 papers); Isotope applications - physiology and biochemistry (2 papers); Isotope applications - chemosterilants (2 papers); Sterile-male technique (9 papers); Radiation effect studies - genetic (5 papers); Isotope applications - genetic (1 paper). Each paper is in its original language (21 English, 11 French, 1 Russian and 1 Spanish) and is preceded by an abstract in English with a second one in the original language if this is not English. Discussions are in English. (author)

An International Standard for specifying the minimum potency of anti-D blood-grouping reagents: evaluation of a candidate preparation in an international collaborative study

NARCIS (Netherlands)

Thorpe, S. J.; Fox, B.; Heath, A. B.; Scott, M.; de Haas, M.; Kochman, S.; Padilla, A.

2006-01-01

The aim of this study was to evaluate a lyophilized monoclonal immunoglobulin M (IgM) anti-D preparation for use as an International Standard to specify a recommended minimum acceptable potency of anti-D blood-grouping reagents. The candidate International Standard (99/836) for specifying the

Investigations on international standardization of environmental management systems. 3; Kankyo kanri system no kokusai hyojunka ni kansuru chosa. 3

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

Japan as an ISO member country identifies the state of discussions in the environmental management standard deliberation committee at ISO. Investigations were performed on international standardization of environmental management systems for the purpose of participating and cooperating in preparing and establishing international standards related to environmental management, and playing part in working, solving and improving environmental problems. Under the circumstances that environmental problems are drawing worldwide interest, the International Organization for Standardization (ISO) has been carrying out since 1993 deliberations on environmental management standards to institutionalize environmental management rules to check effects of business activities on the environment. The International Organization for Standardization/Environmental Management Technical Committee (ISO/TC207) was installed, at which series number of 1400 order was allotted for environmental management related standards, and major standards have come to a final stage of standard formulation at the TC207 Oslo conference in June 1995. In Japan, the Ministry of International Trade and Industry has established an environmental management standard deliberation committee composed of people of experience or academic standing to advance discussions on how the environmental management should be in business entities through deliberations on ISO standards.

International performance-oriented packaging standards adopted in the united states

International Nuclear Information System (INIS)

McCall, D.L.

1993-01-01

On January 1, 1991, the U.S. Department of Transportation (DOT) initiated a transition to adopting a modified version of current international standards for packaging and transporting hazardous materials and hazardous wastes. This transition permits a 5-year phase-in period that will impact all phases of hazardous material transportation including material classification and description, packaging for shipment, and hazard communication standards. These changes are being enacted through the DOT Federal Docket HM-181, 'Performance-Oriented Packaging Standards.' These regulatory standards will have dramatic impact on nearly 5 billion tons of hazardous materials transported within the United States each year. This paper summarizes the principal elements of the new DOT regulations, the latest implementation schedule and impacts on U.S. shipping activities, and discusses outstanding issues that remain to be solved through the next 5 years. (author)

The international growth standard for preadolescent and adolescent children: statistical considerations.

Science.gov (United States)

Cole, T J

2006-12-01

This article discusses statistical considerations for the design of a new study intended to provide an International Growth Standard for Preadolescent and Adolescent Children, including issues such as cross-sectional, longitudinal, and mixed designs; sample-size derivation for the number of populations and number of children per population; modeling of growth centiles of height, weight, and other measurements; and modeling of the adolescent growth spurt. The conclusions are that a mixed longitudinal design will provide information on both growth distance and velocity; samples of children from 5 to 10 sites should be suitable for an international standard (based on political rather than statistical arguments); the samples should be broadly uniform across age but oversampled during puberty, and should include data into adulthood. The LMS method is recommended for constructing measurement centiles, and parametric or semiparametric approaches are available to estimate the timing of the adolescent growth spurt in individuals. If the new standard is to be grafted onto the 2006 World Health Organization (WHO) reference, caution is needed at the join point of 5 years, where children from the new standard are likely to be appreciably more obese than those from the WHO reference, due to the rising trends in obesity and the time gap in data collection between the two surveys.

FY 1999 project on the development of new industry support type international standards. Comprehensive survey research on the promotion of international standardization; 1999 nendo shinki sangyo shiengata kokusai hyojun kaihatsu jigyo seika hokokusho. Kokusai hyojunka suishin ni kakawaru sogo chosa kenkyu

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

For the purpose of promoting the international standardization effectively/strategically, a comprehensive survey was made, and the FY 1999 results were summarized. In the trend survey on the comprehensive international standardization, survey was conducted for companies in the material field (plastics, rubber and iron steel) and in the mechanical field (robot, machinery, aircraft, etc.). As a result of the survey, it was found out that they have few headquarters systems and experts, but they tackle it strategically and defensively, taking the standardization as business. Also as to the trend of CEN/CENELEC, importance of the continued trend survey was pointed out. In the survey of policy for the international standardization, survey was carried out on the trend of the process for working out the international standards (TS, ITS and SDO). Further, in relation to the technology standards and intellectual property rights in the hi-tech field, survey was made on the present situation of rules for handling intellectual property rights of organizations, groups, etc. for standardization, how to handle intellectual property rights in the standardization process, problems and the solution, etc. (NEDO)

International Cooperation to Establish Standard Operating Procedure (SOP) for Quarantine Management of Irradiated Foods in International Trade

Energy Technology Data Exchange (ETDEWEB)

Lee, J. W.; Byun, M. W.; Kim, J. H.; Choi, J. I.; Song, B. S.; Yoon, Y. H.; Kim, D. H.; Kim, W. G.; Kim, K. P.

2010-02-15

{center_dot} Development of SOPs through various research activities such as building international cooperation, and analysing current status of food irradiation in domestic and international markets, export and import, international market size, and of R and D - Analysis of examples for quarantine management in agricultural product exporting countries and use of irradiation technology for agricultural product quarantine, and changes in international quarantine management - Analysis of SOPs for food irradiation quarantine in international organization (CODEX, IPPC, WHO). U.S, EU, China, India, and Australia. - Collaborative researches of India/Korea and China/Korea entered into an agreement for market trials {center_dot} Publishment of irradiation quarantine management SOPs agreed to CODEX standards - Collaborative researches for quarantine management, avoiding Technical Barrier to Trade (TBT), and Sanitary Phytosanitary Measures were conducted, and advanced SOPs agreed with WTO/FTA system were published

Harmonization of the Ukrainian civil service with international and EU standards

Directory of Open Access Journals (Sweden)

L. V. Prudyus

2016-07-01

Full Text Available In the article the issue on harmonization of the civil service with the international and EU standards as one of the key direction of implementation of the Reform Strategy of civil service and service in local self­government bodies for the period up to 2017 was researched. It was established that examples of the most effective management practice can be considered as a standard on which could be oriented states that seek to move to a more efficient and effective public administration. It was approached the issue «European standards of the public administration» as the complex of principles and standards of the establishing and implementation of politics, requirements to the management system. These concepts create will­free and subsequent application to harmonize with the model on building and realization of the modern people oriented public power; «European standards of the civil service» as the requirements to the organization, functionality, structure and management of the civil service system of the EU countries, which established by the legislation and informal cooperation for the ensuring the mission, aim and tasks of the EU and were established by founding treaties. It was summarized that good governance became in the EU as the paradigm for ensuring of the real effect to the democracy values and standards, human rights protection, rule of law, obligatory public administration in all levels. It was implemented according to 12 principles: 1 fair elections, representation and participation; 2 sensitivity to the citizens needs and expectations; 3 efficiency and effectiveness; 4 openness and transparency; 5 the rule of law; 6 ethical behavior; 7 the ability and competence; 8 innovation and openness to change; 9 sustainability and focus on long­term results; 10 sound financial management; 11 human rights, cultural diversity and social cohesion; 12 accountability. It was proven that civil service harmonization with the international and

Development of international standards for instrumentation used for detection of illicit trafficking of radioactive material

International Nuclear Information System (INIS)

Voytchev, M.; Chiaro, P.; Radev, R.

2006-01-01

Subcommittee 45 B 'Radiation Protection Instrumentation' of the International Electrotechnical Commission (I.E.C.) is charged with the development of international standards for instrumentation used for monitoring of illicit trafficking of radioactive material through international boarders and territories, as well as inside countries. Currently three I.E.C. standards are in advanced stages of development. They are expected to be approved and published in 2006-2007. The international participation and the main characteristics of the following three standards are discussed and presented: I.E.C. 62327 'Hand-held Instruments for the Detection and Identification of Radionuclides and Additionally for the Indication of Ambient Dose Equivalent Rate from Photon Radiation', I.E.C. 62401 'Alarming Personal Radiation Devices for Detection of Illicit Trafficking of Radioactive Material' and I.E.C. 62244 'Installed Radiation Monitors for the Detection of Radioactive and Special Nuclear Materials at National Borders'

Synthesis of 15N isotope labeled alanine

International Nuclear Information System (INIS)

Oliveira, Claudineia R. de; Bendassolli, Jose Albertino; Sant'Ana, Carlos Roberto; Tagliassachi, Romulo Barbieri; Maximo, Everaldo; Prestes, Clelber Vieira

2005-01-01

The application of light chemical elements and their stable isotopes in biological studies have been increased over the last years. The use of 15 N labeled amino acids is an important tool for elucidation of peptides structures. This paper describe a method for the synthesis of 15 N isotope labeled alanine at lower costs than international ones, as well as the details of the recovery system of the nitrogen residues. In the present work an amination of α-haloacids, with the bromopropionic carboxylic acid and labeled aqua ammonia ( 15 NH 3 aq) was carried out. In order to avoid eventually losses of 15 NH 3 , special cares were adopted, since the production cost is high. Although the acquisition cost of the 13 N (radioactive) labeled compounds is lower, the obtained stable tracer will allow the accomplishment of important studies of the nitrogen cycling in living things, less occupational and environment hazards, and the time limitation problems in field studies. The tests took place in triplicates with NH 3 (aq) being employed. With the establishment of the system for 15 NH 3 recovery, an average of 94 % of the ammonia employed in the synthesis process was recovered. The purity of the amino acid was state determined by TLC (Thin Layer Chromatography) and HPLC (High-Performance Liquid Chromatography) with a fluorescence detector. The Rf and the retention time of the synthesized sample were similar the sigma standard. Finally, regarding the established conditions, it was possible to obtain the alanine with a production cost about 40 % lower than the international price. (author)

Study of intramolecular isotope heterogeneity of organic oxy acids in order to detect sophisticated wines and juice drinks

Directory of Open Access Journals (Sweden)

Kuzmina Helen

2014-01-01

Full Text Available According to International Code of Oenological Practices it is allowed to use acide L(+tartrique for wine acidification, while use of synthetic dihydroxysuccinic acid is forbidden. Today it is impossible to differentiate natural dihydroxysuccinic acid from synthetic one by standard techniques. Even by using very sensitive method of isotope mass spectrometry certain difficulties emerge because total isotope characteristics of carbon of dihydroxysuccinic acid of different nature have the same values. However, isotope characteristics of carbon of intramolecular structural groups of dihydroxysuccinic acid made of different raw materials differ significantly. This allows specifying the nature of dihydroxysuccinic acid that is used for making of wines and juice drinks. In Russia, scientific and research institute of beer brewing and wine-making industry carried out a work for studying isotope characteristics of intramolecular isotope heterogeneity of dihydroxysuccinic acid from different origins in order to identify wines and juice drinks. Isotope characteristics of organic oxy acids from different origins were studied including them obtained by synthetic way and numeric range of value δ13 C,‰ were specified. The obtained results allow performing identification tests of wines and juice drinks to find out the products that contain not specified additives as that allowed for its use in production process.

Reduction of determinate errors in mass bias-corrected isotope ratios measured using a multi-collector plasma mass spectrometer

International Nuclear Information System (INIS)

Doherty, W.

2015-01-01

A nebulizer-centric instrument response function model of the plasma mass spectrometer was combined with a signal drift model, and the result was used to identify the causes of the non-spectroscopic determinate errors remaining in mass bias-corrected Pb isotope ratios (Tl as internal standard) measured using a multi-collector plasma mass spectrometer. Model calculations, confirmed by measurement, show that the detectable time-dependent errors are a result of the combined effect of signal drift and differences in the coordinates of the Pb and Tl response function maxima (horizontal offset effect). If there are no horizontal offsets, then the mass bias-corrected isotope ratios are approximately constant in time. In the absence of signal drift, the response surface curvature and horizontal offset effects are responsible for proportional errors in the mass bias-corrected isotope ratios. The proportional errors will be different for different analyte isotope ratios and different at every instrument operating point. Consequently, mass bias coefficients calculated using different isotope ratios are not necessarily equal. The error analysis based on the combined model provides strong justification for recommending a three step correction procedure (mass bias correction, drift correction and a proportional error correction, in that order) for isotope ratio measurements using a multi-collector plasma mass spectrometer

Economic consequences of the adoption of the International Financial Reporting Standards: evidences in the research literature

OpenAIRE

Irina-Doina Pãºcan; Ramona Neag

2015-01-01

Along with the economic globalization, the international accounting regulation bodies faced the need to issue internationally accepted global accounting standards. The effect was the issuance and the widespread of the International Financial Reporting Standards (IFRS). At European level, the IFRS gained legitimacy in 2002, when the European Parliament and Council have decided that all European publicly traded entities must prepare their consolidated financial statements in accordance with IFR...

High accuracy determination of trace elements in NIST standard reference materials by isotope dilution ICP-MS

International Nuclear Information System (INIS)

Paulsen, P.J.; Beary, E.S.

1996-01-01

At NIST (National Institute of Standards and Technology), ICP-MS ID (inductively coupled mass spectrometry isotope dilution) has been used to certify a wide range of elements in a variety of materials with high accuracy. Both the chemical preparation and instrumental procedures are simpler than with other ID mass spectrometric techniques. The ICP-MS has picogram/ml detection limits for most elements using fixed operating parameters. Chemical separations are required only to remove an interference (from molecular ions as well as isobaric atoms), or to pre-concentrate the analyte. For example, chemical separations were required for the analysis of SRM 2711, Montana II Soil, but not for boron in peach leaves, SRM 1547.(3 refs., 3 tabs., 2 figs

Determination of Cd and Pb in human blood by isotope dilution inductively coupled plasma mass spectrometry : International comparison

International Nuclear Information System (INIS)

Park, Chang Joon; Suh, Jeong Ki; Lee, Sang Hwa

1996-01-01

Inorganic analytical laboratory of Korea Research Institute of Standards and Science participated in an interlaboratory comparison program operated by Quebec Toxicology Centre of Canada in 1994 and again in 1995. The objective of this program is to enable participating laboratories to assess reproducibility and accuracy of their analytical results for trace toxic elements in human biological fluids. This laboratory determined Cd and Pb concentrations in 3 levels of human blood samples by isotope dilution inductively coupled plasma mass spectrometry. 0.5 mL of blood sample is added to the digestion bomb together with 2 mL of nitric acid and enriched spike isotopes and then decomposed in the microwave digestion system. The decomposed sample is diluted to 10 mL and nebulized into ICP-MS. The Cd and Pb values reported by all participating laboratories are presented and compared. The values reported by this laboratory are within the acceptable range of target values. (author)

The status of isotopic investigations of the Limpopo mobile belt

International Nuclear Information System (INIS)

Barton, J.M. Jr.

1981-01-01

The Limpopo Belt is a zone of multiple deformed metamorphic rocks situated between the Rhodesian and Kaapvaal Cratons of Southern Africa. During the duration of the International Geodynamics Project, geochronologic and isotopic investigations were undertaken in the nothern Transvaal of rocks of the Central Zone, Southern Marginal Zone and Soutpansberg Supergroup. Strontium 86, strontium 87 and lead isotopes were used in the isotopic investigations

Proceedings of the study of environmental change using isotope techniques

Energy Technology Data Exchange (ETDEWEB)

NONE

2002-10-01

Global warming is acknowledged as a major crisis facing society today, principally due to anticipated impacts on the environment, and availability and distribution of water resources. Scientific understanding of recent human-induced climate change, as well as evaluation of potential mitigation strategies, is progressively being developed through studies of atmospheric greenhouse gases and modern water energy carbon cycling processes. These efforts have been advanced through study of past global climate changes to understand mechanisms that play a role in determining natural climate fluctuations observed in ice cores, lake and sea sediments, corals, paleo-groundwater, cave deposits, tree rings, and other archives. Predictive models incorporating natural and human-induced climate change processes contribute to a better appreciation for the sensitivity of climate to specific anthropogenic perturbations. Increasingly, isotopes are being integrated in climate change studies. For example, isotope methodologies offer substantial improvements in the ability to label the origin and fate of greenhouse gases, and for studying the water and carbon cycle response to past climate changes, a high priority area for action identified by the Intergovernmental Panel on Climate Change (IPCC). Isotopes are also widely used as diagnostic variables for validation of models aimed at providing a prognosis of future environmental conditions. The International Atomic Energy Agency (IAEA) has long supported research and development of isotope applications for climate studies. The joint IAEA/WMO Global Network for Isotopes in Precipitation managed by the IAEA has for the last four decades provided the basic isotope data necessary for integrating stable oxygen and hydrogen isotopes in climate models. The IAEA has also sponsored co-ordinated research projects on Isotope Variations of Carbon Dioxide and other Trace Gases in the Atmosphere and Isotope-Aided Studies of Atmospheric Carbon Dioxide

Proceedings of the study of environmental change using isotope techniques

International Nuclear Information System (INIS)

2002-01-01

Global warming is acknowledged as a major crisis facing society today, principally due to anticipated impacts on the environment, and availability and distribution of water resources. Scientific understanding of recent human-induced climate change, as well as evaluation of potential mitigation strategies, is progressively being developed through studies of atmospheric greenhouse gases and modern water energy carbon cycling processes. These efforts have been advanced through study of past global climate changes to understand mechanisms that play a role in determining natural climate fluctuations observed in ice cores, lake and sea sediments, corals, paleo-groundwater, cave deposits, tree rings, and other archives. Predictive models incorporating natural and human-induced climate change processes contribute to a better appreciation for the sensitivity of climate to specific anthropogenic perturbations. Increasingly, isotopes are being integrated in climate change studies. For example, isotope methodologies offer substantial improvements in the ability to label the origin and fate of greenhouse gases, and for studying the water and carbon cycle response to past climate changes, a high priority area for action identified by the Intergovernmental Panel on Climate Change (IPCC). Isotopes are also widely used as diagnostic variables for validation of models aimed at providing a prognosis of future environmental conditions. The International Atomic Energy Agency (IAEA) has long supported research and development of isotope applications for climate studies. The joint IAEA/WMO Global Network for Isotopes in Precipitation managed by the IAEA has for the last four decades provided the basic isotope data necessary for integrating stable oxygen and hydrogen isotopes in climate models. The IAEA has also sponsored co-ordinated research projects on Isotope Variations of Carbon Dioxide and other Trace Gases in the Atmosphere and Isotope-Aided Studies of Atmospheric Carbon Dioxide

Analysis of barium by isotope mass spectrometry

International Nuclear Information System (INIS)

Long Kaiming; Jia Baoting; Liu Xuemei

2004-01-01

The isotopic abundance ratios for barium at sub-microgram level are analyzed by thermal surface ionization mass spectrometry (TIMS). Rhenium trips used for sample preparation are firstly treated to eliminate possible barium background interference. During the preparation of barium samples phosphoric acid is added as an emitting and stabilizing reagent. The addition of phosphoric acid increases the collection efficiency and ion current strength and stability for barium. A relative standard deviation of 0.02% for the isotopic abundance ratio of 137 Ba to 138 Ba is achieved when the 138 Ba ion current is (1-3) x 10 -12 A. The experimental results also demonstrate that the isotope fractionation effect is negligibly small in the isotopic analysis of barium