High frequency plant regeneration from mature seed- derived callus ...

African Journals Online (AJOL)

PRECIOUS

2009-12-15

Dec 15, 2009 ... Ki-Won Lee, Gi Jun Choi, Ki-Yong Kim, Hee Chung Ji, Hyung Soo Park, Sei Hyung Yoon and ... Gramineae family plants (Ha et al., 2001; Dong and Qu, ..... Lee SH, Ahsan N, Lee KW, Kim DH, Lee DG, Kwak SS, Kwon SY, ...

Inhibition of Inducible Nitric Oxide Synthase, Cycleooxygenase-2 ...

African Journals Online (AJOL)

HP

Won Chung, Jin Uk Oh, Sehyung Lee and Sung-Jin Kim* ... was determined by Western blot analysis for iNOS and COX-2 expression in LPS-stimulated RAW ..... Nitric oxide-scavenging and antioxidant effects ofUraria crinite root. Food.

Three-dimensional culture and interaction of cancer cells and dendritic cells in an electrospun nano-submicron hybrid fibrous scaffold

Directory of Open Access Journals (Sweden)

Kim TE

2016-03-01

Full Text Available Tae-Eon Kim,1–3,* Chang Gun Kim,1–3,* Jin Soo Kim,4 Songwan Jin,4 Sik Yoon,5 Hae-Rahn Bae,6 Jeong-Hwa Kim,7,8 Young Hun Jeong,7,8 Jong-Young Kwak1–3 1Department of Pharmacology, School of Medicine, 2Department of Biomedical Sciences, The Graduate School, Ajou University, Suwon, South Korea; 3Immune Network Pioneer Research Center, Ajou University Medical Center, Suwon, South Korea; 4Department of Mechanical Engineering, Korea Polytechnic University, Gyeonggi, South Korea; 5Department of Anatomy, School of Medicine, Pusan National University, Yangsan, South Korea; 6Department of Physiology, College of Medicine, Dong-A University, Busan, South Korea; 7School of Mechanical Engineering, 8Department of Mechanical Engineering, Graduate School, Kyungpook National University, Daegu, South Korea *These authors contributed equally to this work Abstract: An artificial three-dimensional (3D culture system that mimics the tumor microenvironment in vitro is an essential tool for investigating the cross-talk between immune and cancer cells in tumors. In this study, we developed a 3D culture system using an electrospun poly(ε-caprolactone (PCL nanofibrous scaffold (NFS. A hybrid NFS containing an uninterrupted network of nano- and submicron-scale fibers (400 nm to 2 µm was generated by deposition onto a stainless steel mesh instead of an aluminum plate. The hybrid NFS contained multiplanar pores in a 3D structure. Surface-seeded mouse CT26 colon cancer cells and bone marrow-derived dendritic cells (BM-DCs were able to infiltrate the hybrid NFS within several hours. BM-DCs cultured on PCL nanofibers showed a baseline inactive form, and lipopolysaccharide (LPS-activated BM-DCs showed increased expression of CD86 and major histocompatibility complex Class II. Actin and phosphorylated FAK were enriched where unstimulated and LPS-stimulated BM-DCs contacted the fibers in the 3D hybrid NFS. When BM-DCs were cocultured with mitoxantrone-treated CT26 cells in

[Learning experience of acupuncture technique from professor ZHANG Jin].

Science.gov (United States)

Xue, Hongsheng; Zhang, Jin

2017-08-12

As a famous acupuncturist in the world, professor ZHANG Jin believes the key of acupuncture technique is the use of force, and the understanding of the "concentrating the force into needle body" is essential to understand the essence of acupuncture technique. With deep study of Huangdi Neijing ( The Inner Canon of Huangdi ) and Zhenjiu Dacheng ( Compendium of Acupuncture and Moxibustion ), the author further learned professor ZHANG Jin 's theory and operation specification of "concentrating force into needle body, so the force arriving before and together with needle". The whole-body force should be subtly focused on the tip of needle, and gentle force at tip of needle could get significant reinforcing and reducing effect. In addition, proper timing at tip of needle could start reinforcing and reducing effect, lead qi to disease location, and achieve superior clinical efficacy.

Kim Dotcomi kättemaks / Andy Greenberg

Index Scriptorium Estoniae

Greenberg, Andy

2013-01-01

Skandaalne Internetimagnaat Kim Schmitz, rohkem tuntud kui Kim Dotcom, on veendunud, et tema loodud failivahetusprogrammi Megauploadi mahavõtmisega ja autoriõiguste rikkumise süüdistusega tehti talle liiga ning ta on asunud raevukalt vastulöögile USA valitsuse vastu

Development of megestrol acetate solid dispersion nanoparticles for enhanced oral delivery by using a supercritical antisolvent process

Directory of Open Access Journals (Sweden)

Ha ES

2015-08-01

Full Text Available Eun-Sol Ha,1 Jeong-Soo Kim,2 In-hwan Baek,3 Jin-Wook Yoo,1 Yunjin Jung,1 Hyung Ryong Moon,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2Dong-A ST Co Ltd, Yongin, 3College of Pharmacy, Kyungsung University, Busan, South Korea Abstract: In the present study, solid dispersion nanoparticles with a hydrophilic polymer and surfactant were developed using the supercritical antisolvent (SAS process to improve the dissolution and oral absorption of megestrol acetate. The physicochemical properties of the megestrol acetate solid dispersion nanoparticles were characterized using scanning electron microscopy, differential scanning calorimetry, powder X-ray diffraction, and a particle-size analyzer. The dissolution and oral bioavailability of the nanoparticles were also evaluated in rats. The mean particle size of all solid dispersion nanoparticles that were prepared was <500 nm. Powder X-ray diffraction and differential scanning calorimetry measurements showed that megestrol acetate was present in an amorphous or molecular dispersion state within the solid dispersion nanoparticles. Hydroxypropylmethyl cellulose (HPMC solid dispersion nanoparticles significantly increased the maximum dissolution when compared with polyvinylpyrrolidone K30 solid dispersion nanoparticles. The extent and rate of dissolution of megestrol acetate increased after the addition of a surfactant into the HPMC solid dispersion nanoparticles. The most effective surfactant was Ryoto sugar ester L1695, followed by d-a-tocopheryl polyethylene glycol 1000 succinate. In this study, the solid dispersion nanoparticles with a drug:HPMC:Ryoto sugar ester L1695 ratio of 1:2:1 showed >95% rapid dissolution within 30 minutes, in addition to good oral bioavailability, with approximately 4.0- and 5.5-fold higher area under the curve (0–24 hours and maximum concentration, respectively, than raw megestrol acetate powder. These results suggest that the preparation of megestrol

Měkkýši Národní přírodní rezervace Soos Molluscs (Mollusca of the Soos National Nature Reserve

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Jitka Horáčková

2012-12-01

Full Text Available The Soos National Nature Reserve nearby Františkovy Lázně Town (Western Bohemia, Czech Republic is a spectacular peatbog site with the occurrence of fens on numerous mineral spring effluents, emanations of pure carbon dioxide in mofettes (i.e. false mud volcanoes, parts with saltwater wetlands, and diatomite mantel in its central part. These natural conditions affect general character of all habitats, vegetation and malacocoenoses in the reserve. Altogether, 31 mollusc species were found there, but only two of them are considered as near threatened (Pisidium obtusale and Vertigo substriata. The majority of recorded assemblage was composed of common and generalist mollusc species.

[Influences of Confucianism, Taoism and Buddhism on Chinese Medical Formulas in Jin-Tang Dynasties].

Science.gov (United States)

Wu, Xiao-xiang

2006-04-01

In the Jin-Tang Dynasties, when Confucianism, Taoism and Buddhism contended, conflicted and well blent, forming a state of mingled thoughts of the three sects. It exerted profound influences on Chinese Medical Formulas and promoted the academic fashion of compiling books about medical formulas characterized by collecting various formulas especially the simple and proved recipes. This plays a role in the formation of the formulas used in the Jin-Tang Dynasties, featuring simplicity, convenience, cheapness, and effectiveness, different from those of other periods.

Projecting Pyongyang: The Future of North Korea's Kim Jong IL Regime

National Research Council Canada - National Science Library

Scobell, Andrew

2008-01-01

.... In this monograph, the focus is on the fate of the regime dominated by the Kim Dynasty, initially ruled by Kim Il Sung and then led by his son, Kim Jong Il, following the former's death in 1994...

The ten thousand Kims

Science.gov (United States)

Baek, Seung Ki; Minnhagen, Petter; Kim, Beom Jun

2011-07-01

In Korean culture, the names of family members are recorded in special family books. This makes it possible to follow the distribution of Korean family names far back in history. It is shown here that these name distributions are well described by a simple null model, the random group formation (RGF) model. This model makes it possible to predict how the name distributions change and these predictions are shown to be borne out. In particular, the RGF model predicts that for married women entering a collection of family books in a certain year, the occurrence of the most common family name 'Kim' should be directly proportional to the total number of married women with the same proportionality constant for all the years. This prediction is also borne out to a high degree. We speculate that it reflects some inherent social stability in the Korean culture. In addition, we obtain an estimate of the total population of the Korean culture down to the year 500 AD, based on the RGF model, and find about ten thousand Kims.

The ten thousand Kims

International Nuclear Information System (INIS)

Baek, Seung Ki; Minnhagen, Petter; Kim, Beom Jun

2011-01-01

In Korean culture, the names of family members are recorded in special family books. This makes it possible to follow the distribution of Korean family names far back in history. It is shown here that these name distributions are well described by a simple null model, the random group formation (RGF) model. This model makes it possible to predict how the name distributions change and these predictions are shown to be borne out. In particular, the RGF model predicts that for married women entering a collection of family books in a certain year, the occurrence of the most common family name 'Kim' should be directly proportional to the total number of married women with the same proportionality constant for all the years. This prediction is also borne out to a high degree. We speculate that it reflects some inherent social stability in the Korean culture. In addition, we obtain an estimate of the total population of the Korean culture down to the year 500 AD, based on the RGF model, and find about ten thousand Kims.

Farmers of Jin county want fewer children.

Science.gov (United States)

Xiao, M

1986-04-01

The economic reform practiced in the vast rural areas in China gives a great impetus to the vigorous development of rural economy and the the rapid improvement of living standard. Meanwhile, reform pounds at the traditional childbearing ideas. The striking change in the childbearing attitudes of the farmers of the Jin County is a good example. As the farmers of the country are getting well-off when the commodity economy develops rapidly with the rural economic reforms, their childbearing attitudes change. Profound changes have taken place in their mode of production and their life style. The young couples of the county begin to seek small families instead of traditional big ones. They are convinced that under the new situation of reforms, the farmers of an old generation are in no way competent as the head of the family to guide production and therefore want to build their own small families by freeing themselves from the binds of the traditional patriarchal system. The increase in the cost of bringing up children and the economic loss resulting from the absence from work for looking after children constitute another reason to prefer a small family. The son is no more the only economic guarantee for the aged. As a result of the rapid development of the rural economy, a retirement system has been established among the farmers of the Jin county. "It is unreliable to expect that the son will support his aged parents. Now it is better to earn more money and the collective can be depended upon by the aged."

Expression of porcine myosin heavy chain 1 gene in Berkshire loins ...

African Journals Online (AJOL)

Expression of porcine myosin heavy chain 1 gene in Berkshire loins with a high pH24 value. Jin Hun Kang, Woo Young Bang, Eun Jung Kwon, Yong Hwa Lee, Da Hye Park, Eun Seok Cho, Min Ji Kim, Jong-Soon Choi, Hwa Chun Park, Beom Young Park, Chul Wook Kim ...

Colon-targeted delivery of piceatannol enhances anti-colitic effects of the natural product: potential molecular mechanisms for therapeutic enhancement

Directory of Open Access Journals (Sweden)

Yum S

2015-08-01

Full Text Available Soohwan Yum, Seongkeun Jeong, Sunyoung Lee, Joon Nam, Wooseong Kim, Jin-Wook Yoo, Min-Soo Kim, Bok Luel Lee, Yunjin Jung College of Pharmacy, Pusan National University, Busan, Republic of Korea Abstract: Piceatannol (PCT, an anti-colitic natural product, undergoes extensive Phase II hepatic metabolism, resulting in very low bioavailability. We investigated whether colon-targeted delivery of PCT could enhance anti-colitic effects and how therapeutic enhancement occurred at the molecular level. Molecular effects of PCT were examined in human colon carcinoma cells and inflamed colons. The anti-colitic effects of PCT in a colon-targeted capsule (colon-targeted PCT were compared with PCT in a gelatin capsule (conventional PCT in a trinitrobenzene sulfonic acid-induced rat colitis model. Colon-targeted PCT elicited greatly enhanced recovery of the colonic inflammation. In HCT116 cells, PCT inhibited nuclear factor kappaB while activating anti-colitic transcription factors, nuclear factor-erythroid 2 (NF-E2 p45-related factor 2, and hypoxia-inducible factor-1. Colon-targeted PCT, but not conventional PCT, modulated production of the target gene products of the transcription factors in the inflamed colonic tissues. Rectal administration of PCT, which simulates the therapeutic action of colon-targeted PCT, also ameliorated rat colitis and reproduced the molecular effects in the inflamed colonic tissues. Colon-targeted delivery increased therapeutic efficacy of PCT against colitis, likely resulting from multitargeted effects exerted by colon-targeted PCT. The drug delivery technique may be useful for therapeutic optimization of anti-colitic lead compounds including natural products. Keywords: piceatannol, colitis, colon-targeted delivery, multitarget, polypharmacology

Growth characteristics and productivity of cold-tolerant “Kowinearly ...

African Journals Online (AJOL)

Growth characteristics and productivity of cold-tolerant “Kowinearly” Italian ryegrass in the northern part of South Korea. Gi Jun Choi, Hee Chung Ji, Ki-Yong Kim, Hyung Soo Park, Sung Seo, Ki-Won Lee, Sang-Hoon Lee ...

Emissive lead(II) benzenedicarboxylate metal-organic frameworks

Indian Academy of Sciences (India)

Abdul Malik P Peedikakkal

2018-04-16

Apr 16, 2018 ... Jang E, Jun S, Jang H, Lim J, Kim B and Kim Y 2010. White-light-emitting ... 2837; (b) Li Y-F, Wang D, Liao Z, Kang Y, Ding. W-H, Zheng X-J, Jin L-P 2016 .... Zuo J-L and Zhou H-C 2007 Synthesis and Characteri- zations of a ...

Anmeldelse af Kim Wind Andersen: Overblik over selskabers underskudsfremførsel

DEFF Research Database (Denmark)

Werlauff, Erik

2011-01-01

Artiklen anmelder Kim Wind Andersen: Overblik over selskabers underskudsfremførsel (Thomson Reuters Professional, 2010)......Artiklen anmelder Kim Wind Andersen: Overblik over selskabers underskudsfremførsel (Thomson Reuters Professional, 2010)...

A Highly Responsive Silicon Nanowire/Amplifier MOSFET Hybrid Biosensor

Science.gov (United States)

2015-07-21

Hybrid Biosensor Jieun Lee1,2, Jaeman Jang1, Bongsik Choi1, Jinsu Yoon1, Jee-Yeon Kim3, Yang-Kyu Choi3, Dong Myong Kim1, Dae Hwan Kim1 & Sung-Jin Choi1...This study demonstrates a hybrid biosensor comprised of a silicon nanowire (SiNW) integrated with an amplifier MOSFET to improve the current response...of field-effect-transistor (FET)-based biosensors . The hybrid biosensor is fabricated using conventional CMOS technology, which has the potential

Improving dissolution and oral bioavailability of pranlukast hemihydrate by particle surface modification with surfactants and homogenization

Directory of Open Access Journals (Sweden)

Ha ES

2015-06-01

Full Text Available Eun-Sol Ha,1 In-hwan Baek,2 Jin-Wook Yoo,1 Yunjin Jung,1 Min-Soo Kim1 1College of Pharmacy, Pusan National University, 2College of Pharmacy, Kyungsung University, Busan, Republic of Korea Abstract: The present study was carried out to develop an oral formulation of pranlukast hemihydrate with improved dissolution and oral bioavailability using a surface-modified microparticle. Based on solubility measurements, surface-modified pranlukast hemihydrate microparticles were manufactured using the spray-drying method with hydroxypropylmethyl cellulose, sucrose laurate, and water and without the use of an organic solvent. The hydrophilicity of the surface-modified pranlukast hemihydrate microparticle increased, leading to enhanced dissolution and oral bioavailability of pranlukast hemihydrate without a change in crystallinity. The surface-modified microparticles with an hydroxypropylmethyl cellulose/sucrose laurate ratio of 1:2 showed rapid dissolution of up to 85% within 30 minutes in dissolution medium (pH 6.8 and oral bioavailability higher than that of the commercial product, with approximately 2.5-fold and 3.9-fold increases in area under the curve (AUC0→12 h and peak plasma concentration, respectively. Therefore, the surface-modified microparticle is an effective oral drug delivery system for the poorly water-soluble therapeutic pranlukast hemihydrate. Keywords: solubility, wettability, sucrose laurate, cellulose

AMS radiocarbon dating of cemetery of Jin Marquises in China

CERN Document Server

Wu, X; Wang, J; Guo, Z; Liu, K; Lü, X; Ma, H; Li, K; Yuan, J; Cai, L

2000-01-01

Bones are very important samples to determine the hosts of the cemetery of Jin Marquises which were excavated at Tianma-Qucun site in Shanxi Province in China. In order to obtain accurate AMS radiocarbon dates, bones were pretreated by two kinds of methods, the gelatin-extraction method and the amino-acid method. Charcoals collected from the same sites were also used. The measured dates agree with historical record.

REPRESENTATION OF KIM JONG-UN’S SUCCESSION IN BBC NEWS: A CRITICAL DISCOURSE ANALYSIS

Directory of Open Access Journals (Sweden)

Hendra Nugraha

2016-04-01

Full Text Available This research attempts to reveal representation of Kim Jong-Un’s succession in BBC News through textual and discursive practice analysis. The data of this thesis are taken from BBC News website on 29 and 31 December 2011. The theory applied to seek the objective of the research is Critical Discourse Analysis developed by Fairclough. Through textual and discursive practice analysis, the writer finds pthat BBC employs more passive material clauses than active material clauses in depicting Kim Jong-Un’s succession. BBC also represents Kim Jong-Un’s succession as premature process where Kim Jong-Un is portrayed as a young and inexperienced leader. Besides the prematurity of the succession, the present writer finds that BBC represents Kim Jong-Un’s succession as continuity of Kim’s family dynasty. Thus, the succession is based on his resemblance to Kim Il-Sung, the founder of Democratic People’s Republic of Korea, rather than Kim Jong-Un ability and competency.

The New North Korean Problem: History and Responsibilities in the Age of Kim Jong Un

Science.gov (United States)

2012-03-29

Kim Jong Un is the youngest of Kim Jong Il’s three male children. The oldest, Kim Jong Nam was once favored to...passport.49 In a series of interviews with Japanese reporter Yogi Gomi, Kim Jong Nam related his concerns about the future of North Korea and the...4. TITLE AND SUBTITLE THE NEW NORTH KOREAN PROBLEM: HISTORY AND RESPONSIBILITIES IN THE AGE OF KIM JONG UN 5. FUNDING NUMBERS

A 90-day study of sub-chronic oral toxicity of 20 nm positively charged zinc oxide nanoparticles in Sprague Dawley rats

Directory of Open Access Journals (Sweden)

Park HS

2014-12-01

Full Text Available Hark-Soo Park,1 Seon-Ju Kim,1 Taek-Jin Lee,1 Geon-Yong Kim,1 EunHo Meang,1 Jeong-Sup Hong,1 Su-Hyon Kim,1 Sang-Bum Koh,1 Seung-Guk Hong,1 Yle-Shik Sun,1 Jin Seok Kang,2 Yu-Ri Kim,3 Meyoung-Kon Kim,3 Jayoung Jeong,4 Jong-Kwon Lee,4 Woo-Chan Son,5 Jae-Hak Park61General Toxicology Team, Korea Testing and Research Institute, Seoul, 2Department of Biomedical Laboratory Science, Namseoul University, Cheonan, 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 4National Institute of Food and Drug Safety Evaluation, Seoul, 5Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, 6Laboratory Animal Medicine, College of Veterinary Medicine, Seoul National University, Seoul, KoreaPurpose: The study reported here was conducted to determine the systemic oral toxicity and to find the no-observed-adverse-effect level of 20 nm positively charged zinc oxide (ZnOSM,20(+ nanoparticles in Sprague Dawley rats for 90 days.Methods: For the 90-day toxicity study, the high dose was set as 500 mg per kg of body weight (mg/kg and the middle and low dose were set to 250 mg/kg and 125 mg/kg, respectively. The rats were held for a 14-day recovery period after the last administration, to observe for the persistence or reduction of any toxic effects. A distributional study was also carried out for the systemic distribution of ZnOSM,20(+ NPs.Results: No rats died during the test period. There were no significant clinical changes due to the test article during the experimental period in functional assessment, body weight, food and water consumption, ophthalmological testing, urine analysis, necropsy findings, or organ weights, but salivation was observed immediately after administration in both sexes. The total red blood cell count was increased, and hematocrit, albumin, mean cell volume, mean cell hemoglobin, and mean cell hemoglobin concentration were decreased significantly compared with

Spotlight on nano-theranostics in South Korea: applications in diagnostics and treatment of diseases

Directory of Open Access Journals (Sweden)

Lee S

2015-08-01

Full Text Available Sangwha Lee,1,* Jongsung Kim,1,* Chung Wung Bark,2 Bonghee Lee,3 Heongkyu Ju,4 Se Chan Kang,5 TaeYoung Kim,6 Moon Il Kim,6 Young Tag Ko,3 Jeong-Seok Nam,3 Hyon Hee Yoon,1 Kyu-Sik Yun,1,6 Young Soo Yoon,1 Seong Soo A An,1,6 John Hulme6 1BioNano Sensor Research Center, 2Department of Electrical Engineering, Gachon University, Seongnam-si, 3Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, 4Department of Nano-Physics, 5Department of Life Science, Gachon University, 6Department of BioNano Technology, Gachon BioNano Research Institute, Seongnam-si, South Korea *These authors contributed equally to this work Abstract: From the synergistic integration and the multidisciplinary strengths of the BioNano Sensor Research Center, Gachon Bionano Research Institute, and Lee GilYa Cancer and Diabetes Institute, researchers, students, and faculties at Gachon University in collaboration with other institutions in Korea, Australia, France, America, and Japan have come together to produce a special issue on the diverse applications of nano-theranostics in nanomedicine. This special issue will showcase new research conducted by various scientific groups in Gyonggi-do and Songdo/Incheon, South Korea. The objectives of this special issue are as follows: 1 to bring together and demonstrate some of the latest research results in the field, 2 to introduce new multifunctional nanomaterials and their applications in imaging and detection methods, and 3 to stimulate collaborative interdisciplinary research at both national and international levels in nanomedicine. Keywords: cancer, imaging and therapeutics, antibacterial, disease, neurodegenerative

Lapset median käyttäjinä

OpenAIRE

Jalonen, Taru; Suomela, Sonja

2010-01-01

Laurea-ammattikorkeakoulu Tiivistelmä Hyvinkää Sosiaali-, terveys- ja liikunta-ala Hoitotyön koulutusohjelma Terveydenhoitaja AMK Sairaanhoitaja AMK Taru Jalonen, Sonja Suomela Lapset median käyttäjinä Vuosi ‎2010‎ Sivumäärä ‎63‎ Tämän opinnäytetyön tarkoituksena oli selvittää lasten tottumuksia ja kokemuksia mediasta sekä ‎niiden herättämiä tunteita. Lisäksi selvitimme lasten käyttämiä mediaympäristöjä sekä median ‎näkymistä lasten leikeissä. Tämä työ on os...

Study on embodied CO2 transfer between the Jing-Jin-Ji region and other regions in China: a quantification using an interregional input-output model.

Science.gov (United States)

Chen, Mengmeng; Wu, Sanmang; Lei, Yalin; Li, Shantong

2018-03-08

Jing-Jin-Ji region (i.e., Beijing, Tianjin, and Hebei) is China's key development region, but it is also the leading and most serious air pollution region in China. High fossil fuel consumption is the major source of both carbon dioxide (CO 2 ) emissions and air pollutants. Therefore, it is important to reveal the source of CO 2 emissions to control the air pollution in the Jing-Jin-Ji region. In this study, an interregional input-output model was applied to quantitatively estimate the embodied CO 2 transfer between Jing-Jin-Ji region and other region in China using China's interregional input-output data in 2010. The results indicated that there was a significant difference in the production-based CO 2 emissions in China, and furthermore, the Jing-Jin-Ji region and its surrounding regions were the main regions of the production-based CO 2 emissions in China. Hebei Province exported a large amount of embodied CO 2 to meet the investment, consumption, and export demands of Beijing and Tianjin. The Jing-Jin-Ji regions exported a great deal of embodied CO 2 to the coastal provinces of southeast China and imported it from neighboring provinces.

Interprovincial transfer of embodied energy between the Jing-Jin-Ji area and other provinces in China: A quantification using interprovincial input-output model.

Science.gov (United States)

Chen, Weiming; Wu, Sanmang; Lei, Yalin; Li, Shantong

2017-04-15

Commodity trade between regions implies a large amount of energy transfer. As an important economic growth pole of China, the Jing-Jin-Ji area (Beijing-Tianjin-Hebei) is also one of the areas with the largest energy consumption in China. Moreover, the primary energy consumer goods in this area are fossil fuels, such as coal. This has led to serious air pollution in the area. Therefore, the reduction of energy consumption under the premise of maintaining sustained economic growth is an important task of the Jing-Jin-Ji area. In this study, an interprovincial input-output model was applied to quantitatively estimate the embodied energy transfer between Jing-Jin-Ji area and other provinces in China. The results indicated that the Metal and nonmetal mineral processing industry and the Electrical, gas and water industry in the Jing-Jin-Ji area exported a large amount of embodied energy to the Yangtze River Delta and the Pearl River Delta. However, the embodied energy export of the Jing-Jin-Ji area mainly exported by Hebei province. Beijing and Tianjin even have some net import of embodied energy. The embodied energy transfer between Tianjin, Hebei and other provinces was mainly driven by investment, while the main media of embodied energy transfer between Beijing and other provinces was consumption. Therefore, we suggest that the Jing-Jin-Ji area should further increase the degree of dependence on other provinces' energy-intensive products and reduce the export of energy-intensive products. In addition, there should be difference in the energy and industrial policies among Beijing, Tianjin and Hebei, and the problems of high energy consumption and high proportion of heavy industry in Hebei should be first resolved. Copyright © 2017 Elsevier B.V. All rights reserved.

Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer

OpenAIRE

Park G; Bae SH; Park W; Han S; Park M; Shin S; Shin YG; Yim DS

2017-01-01

Gab-jin Park,1 Soo Hyeon Bae,1 Wan-Su Park,1 Seunghoon Han,1 Min-Ho Park,2 Seok-Ho Shin,2 Young G Shin,2 Dong-Seok Yim1,2 1Department of Clinical Pharmacology and Therapeutics, Seoul St Mary’s Hospital, PIPET (Pharmacometrics Institute for Practical Education and Training), College of Medicine, Catholic University of Korea, Seoul, South Korea; 2College of Pharmacy, Chungnam National University, Daejeon, South Korea Purpose: A microdose drug–drug interaction (DDI) study may be a ...

Research of Ancient Architectures in Jin-Fen Area Based on GIS&BIM Technology

Science.gov (United States)

Jia, Jing; Zheng, Qiuhong; Gao, Huiying; Sun, Hai

2017-05-01

The number of well-preserved ancient buildings located in Shanxi Province, enjoying the absolute maximum proportion of ancient architectures in China, is about 18418, among which, 9053 buildings have the structural style of wood frame. The value of the application of BIM (Building Information Modeling) and GIS (Geographic Information System) is gradually probed and testified in the corresponding fields of ancient architecture’s spatial distribution information management, routine maintenance and special conservation & restoration, the evaluation and simulation of related disasters, such as earthquake. The research objects are ancient architectures in JIN-FEN area, which were first investigated by Sicheng LIANG and recorded in his work of “Chinese ancient architectures survey report”. The research objects, i.e. the ancient architectures in Jin-Fen area include those in Sicheng LIANG’s investigation, and further adjustments were made through authors’ on-site investigation and literature searching & collection. During this research process, the spatial distributing Geodatabase of research objects is established utilizing GIS. The BIM components library for ancient buildings is formed combining on-site investigation data and precedent classic works, such as “Yingzao Fashi”, a treatise on architectural methods in Song Dynasty, “Yongle Encyclopedia” and “Gongcheng Zuofa Zeli”, case collections of engineering practice, by the Ministry of Construction of Qing Dynasty. A building of Guangsheng temple in Hongtong county is selected as an example to elaborate the BIM model construction process based on the BIM components library for ancient buildings. Based on the foregoing work results of spatial distribution data, attribute data of features, 3D graphic information and parametric building information model, the information management system for ancient architectures in Jin-Fen Area, utilizing GIS&BIM technology, could be constructed to support the

The health care burden of high grade chronic obstructive pulmonary disease in Korea: analysis of the Korean Health Insurance Review and Assessment Service data

Directory of Open Access Journals (Sweden)

Kim JH

2013-11-01

Full Text Available JinHee Kim,1 Chin Kook Rhee,2 Kwang Ha Yoo,3 Young Sam Kim,4 Sei Won Lee,5 Yong Bum Park,6 Jin Hwa Lee,7 YeonMok Oh,5 Sang Do Lee,5 Yuri Kim,8 KyungJoo Kim,8 HyoungKyu Yoon9 1Office of Health Service Research, National Evidence-Based Healthcare Collaborating Agency, Seoul, Korea; 2Department of Internal Medicine, Seoul St Mary’s Hospital, Catholic University of Korea College of Medicine, Seoul, Korea; 3Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Korea; 4Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea; 5Department of Pulmonary and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 6Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, Korea; 7Department of Internal Medicine, School of Medicine, Ewha Womans University, Seoul, Korea; 8Department of Clinical Research Support, National Strategic Coordinating Center for Clinical Research, Seoul, Korea; 9Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, Catholic University of Korea College of Medicine, Seoul, Korea Background: Patients with high grade chronic pulmonary obstructive disease (COPD account for much of the COPD-related mortality and incur excessive financial burdens and medical care utilization. We aimed to determine the characteristics and medical care use of such patients using nationwide data from the Korean Health Insurance Review and Assessment Service in 2009. Materials and methods: Patients with COPD were identified by searching with the International Classification of Diseases–10th Revision for those using medication. Patients with high grade COPD were selected based on their patterns of tertiary institute visits and medication use. Results: The numbers of patients with high grade COPD increased rapidly

Height and sex is strongly associated with radial augmentation index in Korean patients with never-treated hypertension

Directory of Open Access Journals (Sweden)

Ahn KT

2016-04-01

Full Text Available Kye Taek Ahn, Kwang-In Park, Mi Joo Kim, Jin Kyung Oh, Ji Hye Han, Hee Jin Kwon, Seon-Ah Jin, Jun-Hyung Kim, Jae-Hyeong Park, Jae-Hwan Lee, Si Wan Choi, In-Whan Seong, Jin-Ok Jeong Department of Internal Medicine, Division of Cardiology, Chungnam National University Hospital, Chungnam National University School of Medicine, Daejeon, Republic of Korea Objectives: Central hemodynamics may better represent the load imposed on the coronary and cerebral arteries and thereby bear a stronger relationship to cardiovascular outcomes. Methods: Patients who had confirmed hypertension as assessed by daytime 24-hour ambulatory blood pressure monitoring (≥135/85 mmHg were enrolled. Central blood pressure and radial augmentation index (AIx corrected for a heart rate of 75 bpm (radial AIx 75 were measured for all patients. We evaluated the association of age, height, and sex with central hemodynamics in patients with never-treated hypertension. Results: A total of 203 patients were enrolled, of whom men numbered 101 (49.7%. The median height of all patients was 162 cm, and mean age was 53.2 years. In the Pearson correlation analysis, regardless of sex difference (R=-0.627 for height, R=0.035 for age, P-value =0.005, a stronger relationship was observed between height and radial AIx 75 than between age and radial AIx 75. In the multiple regression analysis, the sex difference and height were strongly associated with elevated radial AIx 75 in all patients (adjusted R2=0.428, β=6.237, 95% confidence interval [CI] for women 1.480–10.995, P-value =0.011 and β=-0.632, 95% CI for height -0.929 to -0.335, P-value =0.009, respectively. Conclusion: In patients with never-treated hypertension, female sex and shorter height are the important risk factors of elevated radial AIx 75. Keywords: hypertension, augmentation index, height, sex

Journal of Biosciences | Indian Academy of Sciences

Indian Academy of Sciences (India)

Author Affiliations. Eul-Won Hwang1 Kyung-A Kim1 Soo-Chul Park2 Mi-Jeong Jeong2 Myung-Ok Byun2 Hawk-Bin Kwon1. Division of Applied Biological Sciences, Sunmoon University, Asan, 336-708, Korea; Abiotic and Biotic Stress Team, National Institute of Agricultural Biotechnology, Suwon 441-707, Korea ...

Die brein soos beskou deur die Grieke en Romeine

Directory of Open Access Journals (Sweden)

Francois P. Retief

2015-02-01

Full Text Available In Ou Egipte is mummifikasie met uitgebreide reseksie of uitsnyding van organe geassosieer, maar geen kennis is geneem van die morfologie van die brein nie. Griekse skrywers van die sesde en vyfde eeue v.C. het die brein aanvanklik gesien as die setel van intelligensie, die orgaan van sensoriese waarneming en gedeeltelik die oorsprong van sperma. Pneuma het ’n belangrike rol in breinfunksie gespeel. Hippokrates was die eerste om die brein te beskryf as ’n dubbele orgaan, wat met harsingvlies (meninges bedek, funksioneel van pneuma afhanklik en vertolker van begrip is. Tydgenote soos Plato, Aristoteles en Diokles het tot die beskrywing bygedra, maar laasgenoemde twee het beweer dat die hart die middelpunt van intelligensie is en nie die brein nie. Gedurende die laaste helfte van die vierde eeu v.C. is disseksie van die menslike liggaam tydelik aan die mediese skool van Alexandrië toegelaat en het dit tot merkwaardige vooruitgang in die begrip van die menslike anatomie en fisiologie gelei. Herofilus en Erasistratus het uitstekende beskrywings van die struktuur en funksie van die brein gegee wat eers in die tweede eeu n.C. deur Galenus geëwenaar is.

Research of Ancient Architectures in Jin-Fen Area Based on GIS and BIM Technology

International Nuclear Information System (INIS)

Jia, Jing; Zheng, Qiuhong; Gao, Huiying; Sun, Hai

2017-01-01

The number of well-preserved ancient buildings located in Shanxi Province, enjoying the absolute maximum proportion of ancient architectures in China, is about 18418, among which, 9053 buildings have the structural style of wood frame. The value of the application of BIM (Building Information Modeling) and GIS (Geographic Information System) is gradually probed and testified in the corresponding fields of ancient architecture’s spatial distribution information management, routine maintenance and special conservation and restoration, the evaluation and simulation of related disasters, such as earthquake. The research objects are ancient architectures in JIN-FEN area, which were first investigated by Sicheng LIANG and recorded in his work of “Chinese ancient architectures survey report”. The research objects, i.e. the ancient architectures in Jin-Fen area include those in Sicheng LIANG’s investigation, and further adjustments were made through authors’ on-site investigation and literature searching and collection. During this research process, the spatial distributing Geodatabase of research objects is established utilizing GIS. The BIM components library for ancient buildings is formed combining on-site investigation data and precedent classic works, such as “Yingzao Fashi”, a treatise on architectural methods in Song Dynasty, “Yongle Encyclopedia” and “Gongcheng Zuofa Zeli”, case collections of engineering practice, by the Ministry of Construction of Qing Dynasty. A building of Guangsheng temple in Hongtong county is selected as an example to elaborate the BIM model construction process based on the BIM components library for ancient buildings. Based on the foregoing work results of spatial distribution data, attribute data of features, 3D graphic information and parametric building information model, the information management system for ancient architectures in Jin-Fen Area, utilizing GIS and BIM technology, could be constructed to support

Introductory Statement by Won-Soo Kim [International Conference on Nuclear Security: Commitments and Actions, Vienna (Austria), 5-9 December 2016

International Nuclear Information System (INIS)

Kim, Won-Soo

2017-01-01

We need to treat WMD risks and threats holistically. Lessons learned in one area can be emulated in another. The IAEA has learned valuable lessons through its own emergency management work and partnership with other UN agencies, including through the UN Counter-Terrorism Implementation Task Force. These lessons could be beneficial in developing response mechanisms for biological incidents.

Children on Social Media, Twiter and Facebook (profile of Beyonce and Kim Kardashian

Directory of Open Access Journals (Sweden)

Anamarija Bilan

2017-09-01

Full Text Available Publishing children’s photos in the media violates their privacy right, which is protected, guaranteed and regulated by numerous international and Croatian laws and regulations. Likewise, publishing photos of children on social network profiles, such as Facebook or Twitter, violates the right to privacy. In this paper it will be researched the extent to which children’s photos are being disclosed and their privacy is being undermined in case of two Facebook and two Twitter profiles - Beyonce Knowles and Kim Kardashian. It will also research whether children are used for business purposes, whether they are advertising some of their products or shows, and so on, with the photographs of children. The content analysis methodology analyzed the Facebook and Twitter profiles of two respondents in the period from January 1 to February 22, 2016, during which they published a total of 459 posts on profiles of both networks. The analysis found that the total number of “posts” shows a small number of photographs of children but also that those published by Kim Kardashian are often used to promote or promote some of the products or programs, which violates the privacy of children and increases the number “like”.

Even a monkey can understand fan activism: Political speech, artistic expression, and a public for the Japanese dôjin community

Directory of Open Access Journals (Sweden)

Alex Leavitt

2012-06-01

Full Text Available We examine the creation of dôjinshi works critiquing the passage of the metropolitan Tokyo ordinance Bill 156 in December 2010 as a case of fan-driven political activism. Bill 156 aims to limit artistic freedom and is specifically targeted at anime, manga, and other works of visual pop culture. Fans who participate in dôjin production perform both a love for this media and an active form of citizenship that is historically fannish but transformative beyond the mere appropriation and remix of media texts. We argue that dôjin fans and works constitute a recursive public, wherein participants actively create discourse around artistic and ideological issues while engaging in added layers of discourse regarding the maintenance of their existence as a public. We examine fan discourse and dôjin works engaging Bill 156 as an object for political activism, as anime and manga otaku perform their citizenship in the wider society of Japan for their local public and for a global audience of like-minded fans.

The association between combined non-cystic fibrosis bronchiectasis and lung cancer in patients with chronic obstructive lung disease

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Kim YW

2015-05-01

Full Text Available Yeon Wook Kim,1 Kwang-Nam Jin,2 Eun Young Heo,3 Sung Soo Park,3 Hee Soon Chung,3 Deog Kyeom Kim31Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea; 2Department of Radiology, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of KoreaBackground: Whereas the epidemiological association between lung cancer and chronic obstructive pulmonary disease (COPD, a chronic inflammatory respiratory disease, is well known, limited studies have examined the association between lung cancer and non-cystic fibrosis bronchiectasis, a representative chronic airway inflammatory disease. This study evaluated the association between bronchiectasis and lung cancer in patients with COPD.Methods: A matched case–control study was conducted in a referral hospital in South Korea. Among COPD patients with moderate to very severe airflow limitation (forced expiratory volume in one second/forced vital capacity <0.7 and forced expiratory volume in one second ≤70% [% predicted] who underwent chest computed tomography (CT between January 1, 2010 and May 30, 2013, patients with lung cancer and controls matched for age, sex, and smoking history were selected. The risk of lung cancer was assessed according to the presence of underlying bronchiectasis confirmed by chest CT.Results: The study enrolled 99 cases and 198 controls. Combined bronchiectasis on chest CT was inversely associated with the risk of lung cancer compared with controls (odds ratio [OR] 0.25, 95% confidence interval [CI] 0.12–0.52, P<0.001. Significant associations were found in

The Measurement of Urbanization Level Based on Entity Space: A Case Study of JingJinJi Region, China

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Wen Fenghua

2017-01-01

Full Text Available On the basis of analyzing the pros and cons of different urbanization level measurement methods, this paper puts forward urbanization level measurement method based on entity space and then uses entity space data to describe the urbanization rate of various districts and counties of JingJinJi Region in 2005 and 2009. According to the analysis of time and space differences on such basis, JingJinJi may be divided from high to low order according to the urbanization rate of the entity space: central urban area, urban development area and suburb, which respectively bear different functions. According to the comparison of entity space urbanization rate and population urbanization rate in the aspects of sequence, primacy ratio, zipf index, etc., we find the non-intensive land use status quo of urban development area of JingJinJi and the feature that the distribution of entity space urbanization scale is much uniform than distribution of population urbanization scale. Accordingly, the paper puts forward the following suggestions : (1 The space construction should depend upon function division; (2 The urban development area should pay attention to the construction of the supporting facilities and meanwhile enhance land use rate; (3 The urban construction should be enhanced in small and middle regions and counties surrounding Beijing and Tianjin.

DsRed gene expression by doxycycline in porcine fibroblasts and ...

African Journals Online (AJOL)

DsRed gene expression by doxycycline in porcine fibroblasts and cloned embryos using transposon. SuJin Kim, JoonHo Moon, BegoRoibas da Torre, Islam M Saadeldin, JungTaek Kang, JiYei Choi, SolJi Park, Byeong-Chun Lee, Goo Jang Goo Jang ...

Fluorinated Materials for Air-stable and Moisture-resistant Flexible Optoelectronics

Science.gov (United States)

2014-01-02

Kim Jong , H.; Shin, S.; Yang, H.; An, B.-K.; Yang, L.; Park Soo, Y. Adv Mater 2012, 24, 911-915; (c) Geng, Y.; Li, H.-B.; Wu, S.-X.; Su, Z.-M. J...Park, J.-U.; Shir, D. J.-L.; Nam , Y.-S.; Jeon, S.; Rogers, J. A. Chem. Rev. 2007, 107, 1117-1160; (g) Murphy, A. R.; Frechet, J. M. J. Chem. Rev. 2007...2649-2655; (w) Song, H.-J.; Kim , D.-H.; Lee, E.-J.; Heo, S.-W.; Lee, J.-Y.; Moon, D.-K. Macromolecules (Washington, DC, U. S.) 2012, 45, 7815- 7822; (x

[Evaluation on efficacy of Jin's "Sanzhen" therapy combined with rehabilitation training for hemiplegia of stroke patients by Fugl-Meyer scale].

Science.gov (United States)

Han, De-Xiong; Zhuang, Li-Xing; Zhang, Ying

2011-06-01

To assess the therapeutic effect of Jin's "Sanzhen" therapy combined with rehabilitation training on limb-motor function of stroke patients by using Fugl-Meyer scale. A total of 254 hemiplegic stroke outpatients and inpatients from 7 hospitals were randomly divided into Jin's "Sanzhen" (JSZ) group (n = 83), rehabilitation group (n = 84) and combination group (n = 87). Acupuncture was applied to acupoints of Jin's "Sanzhen" including Quchi (LI 11), Waiguan (SJ 5) and Hegu (LI 4); Futu (ST 32). Zusanli (ST 36) and Sanyinjiao (SP 6); etc. The acupuncture needles were retained for 30 min after "Deqi". Rehabilitation training included passive joint movement, standing-sitting training, tapping-pressing stimulation, walking training, etc. The treatment was conducted once daily, 5 sessions a week and for 4 weeks. Fugl-Meyer scale composed of 100-point motor domain of the upper- and lower-extremity sections was used to assess the patients' motor function. On day 28 after the treatment, of the 83.84 and 87 hemiplegic stroke patients in the JSZ, rehabilitation and combination groups, 48 (57.8%), 31 (36.9%) and 50 (57.5%) experienced marked improvement in their clinical symptoms and signs, 26 (31.3%), 44 (52.4%) and 31(35.6%) had an improvement, and 9 (10.8%), 9 (10.7%) and 6 (6.9%) failed in the treatment, with the total effective rates being 89.2%, 89.3% and 93.1%, respectively. The neurological deficit score (NDS) of the combination group was significantly lower than that of the rehabilitation group (P rehabilitation groups (P rehabilitation groups in both NDS and FMAS (P > 0.05). Jin's "Sanzhen" therapy combined with rehabilitation training can significantly improve the limb motor function of hemiplegic stroke patients, and has a good synergistic effect.

North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A First Year Assessment

Science.gov (United States)

2013-09-01

Kim Jong-un’s ’Sick’ Aunt Resurfaces,” Chosun Ilbo Online, 27 July 2013. Kim has a reported history of alcoholism and depression , which was...exacer- bated in the mid-2000s with her marital problems and the death of her daughter, Jang Kum-song, who committed suicide in 2006. Some reports claim...the Party and state apparatus. She was born in 1974, and, when in her teens , began work in Kim Il-sung’s Presidential Office. She moved over to the

Urinary KIM-1 and AQP-1 in patients with clear renal cell carcinoma: Potential noninvasive biomarkers

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Mijušković Mirjana

2016-01-01

Full Text Available Background/Aim. Kidney injury molecule-1 (KIM-1 and aquaporin-1 (AQP-1 are potential early urinary biomarkers of clear renal cell carcinoma (cRCC. The aim of this study was to ascertain relationship between the urine concentrations KIM-1 and AQP-1 with tumor size, grade, pT stage and type of operation (radical or partial nephrectomy in patients with cRCC. Methods. Urinary concentrations of urinary KIM-1 (uKIM-1 and urinary AQP-1 (uAQP-1 were determined by commercially available ELISA kits. The analysis included 40 patients undergoing partial or radical nephrectomy for cRCC and 40 age- and sex-matched healthy adult volunteers. Results. The median preoperative concentrations of KIM-1 in the cRCC group [0.724 ± 1.120 ng/mg urinary creatinine (Ucr] were significantly greater compared with controls (healthy volunteers (0.210 ± 0.082 ng/mgUcr (p = 0.0227. Postoperatively, uKIM-1 concentration decreased significantly to control values (0.177 ± 0.099 ng/mgUcr vs 0.210 ± 0.082 ng/mgUcr, respectively. The size, grade and stage of tumor were correlated positively with preoperative uKIM-1 concentrations. Contrary to these results, concentrations of uAQP-1 in the cRCC group were significantly lower (0.111 ± 0.092 ng/mgUcr compared with the control group (0.202 ± 0.078 ng/mgUcr (p = 0.0014. Postoperatively, the concentrations of uAQP-1 increased progressively up to control values, approximately. We find no significant correlation between preoperative uAQP-1 concentrations and tumor size, grade and stage. Conclusion. uKIM-1 was found to be a reliable diagnostic marker of cRCC, based on its significantly increased values before and decreased values after the nephrectomy. [Projekat Ministarstva nauke Republike Srbije, br. III41018

Fermentation characteristics of Korean pear (Pyrus pyrifolia Nakai ...

African Journals Online (AJOL)

USER

2010-08-30

Aug 30, 2010 ... Dong Chung Kim1, Hee Jeong Chae2,3 and Man-Jin In1*. 1Department of Human ... 0.3% proteins and 0.2% lipids (Hwang and Park, 2006). It is primarily consumed as ..... Khan SH, Ansari FA (2007). Probiotics – the friendly ...

Coenite seiklused ja Kim Ki-duki huumor / Merit Kask

Index Scriptorium Estoniae

Kask, Merit

2007-01-01

60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

Prikljutshenija Koenov i jumor Kim Ki-duka / Merit Kask

Index Scriptorium Estoniae

Kask, Merit

2007-01-01

60-nda Cannes'i filmifestivali filme : Ethan ja Joel Coen'i "Pole maad vanadele meestele" ("No Country for Old Men" ; Ameerika Ühendriigid), Kim Ki-duki "Hingetõmme" ("Soom"/"Breath" ; Lõuna-Korea) ja Raphael Nadjari "Tehilim" (Prantsusmaa - Iisrael - Ameerika Ühendriigid)

Chang Sei Kim's Activities on Public Health in Colonial Korea

Directory of Open Access Journals (Sweden)

Park Yunjae

2006-12-01

Full Text Available After graduating from Severance Medical College in 1916, Chang Sei Kim went to Shanghai to work as a missionary in a adventist hospital. The establishment of the Korean Provisional Government led him to participate in the independence movement. Educating nurses to assist the forthcoming war for independence, he seemed to realize the fact that the health of Koreans would be a key factor for achieving independence. He left for the U.S. to conduct comprehensive research on medicine. Chang Sei Kim was the first Korean to receive a Ph. D. degree of Public Health, graduating from the Johns Hopkins School of Hygiene and Public Health in 1925. He then gained an opportunity to work for Korea as a professor at Severance Medical College. His objective was the 'Reconstruction of the Korean People In Terms of Physical Constitution.' He pointed out that Koreans' weak state of health was a major reason for Korea's colonization. To gain independence, he emphasized that the Korean people should receive education on public health in order to improve the primitive conditions of sanitation. There is little doubt that Chang Sei Kim's ideas developed Heungsadan's views on medicine in terms of its stress on cultivation of ability, especially considering the fact that he was a member of the organization. As a member of the colonized who could not participate in the developing official policy, Chang Sei Kim was not able to implement his ideas fully, because an individual or a private organization could not carry out policy on public health as large a scale as the government did. Never giving up his hopes for Korean independence, he rejected requests to assume official posts in the Government-General. That was why he was particularly interested in the Self-Governing Movement in 1920s Korea. If the movement had attained its goal, he might have worked for the enhancement of sanitary environment as a director of Sanitary Department. His application for funding to establish

Bridging communication between public and government: a case study on kim surabaya

Science.gov (United States)

Aji, G. G.; Tsuroyya; Dewi, P. A. R.

2018-01-01

In democratic era, the public communication paradigm has shifted from a one-way socialization to more interactive one. As a consequence of freedom of speech, the public can Actively communicate with the government and vice versa. The problem is government is almost impossible to reach all public groups. Therefore, they has created the concept of social institutions as a communication hub between the government and its public, named the Kelompok Informasi Masyarakat (KIM). This research examines the activity of KIM in Surabaya on bridging public between government and the public. Using a case study approach, this research utilized various techniques of data collection such as: interviews, observation, and documentation. The results Showed that KIM plays a role in the two-way flow of information; to diseminate program and submit complaints and suggestions from the public about the policy. This study confirm the urgency of utilization on various channels in communicating with the public.

Teasing out the compressed education debates in contemporary South Korea: Media portrayal of figure skater Yuna Kim

OpenAIRE

Kim, Hye Jin

2013-01-01

In this thesis, I argue that the heated debates about South Korea’s education policy consist of problems that arise from different genres of discourses that in turn belong to different historical moments and education values. I engage in a media discourse analysis of the reportage on South Korean international sport celebrity Yuna Kim that highlight the key education debates currently taking place in South Korea. First, I deal with the neologism umchinttal (my mom’s friend’s daughter) as an i...

Novel electrosprayed nanospherules for enhanced aqueous solubility and oral bioavailability of poorly water-soluble fenofibrate

Directory of Open Access Journals (Sweden)

Yousaf AM

2016-01-01

Full Text Available Abid Mehmood Yousaf,1,2 Omer Mustapha,1 Dong Wuk Kim,1 Dong Shik Kim,1 Kyeong Soo Kim,1 Sung Giu Jin,1 Chul Soon Yong,3 Yu Seok Youn,4 Yu-Kyoung Oh,5 Jong Oh Kim,3 Han-Gon Choi1 1College of Pharmacy and Institute of Pharmaceutical Science and Technology, Hanyang University, Ansan, Gyeonggi, South Korea; 2Faculty of Pharmacy, University of Central Punjab, Johar, Lahore, Pakistan; 3College of Pharmacy, Yeungnam University, Gyongsan, North Gyeongsang, 4School of Pharmacy, Sungkyunkwan University, Suwon, Gyeonggi, 5College of Pharmacy, Seoul National University, Seoul, South Korea Purpose: The purpose of the present research was to develop a novel electrosprayed nanospherule providing the most optimized aqueous solubility and oral bioavailability for poorly water-soluble fenofibrate.Methods: Numerous fenofibrate-loaded electrosprayed nanospherules were prepared with polyvinylpyrrolidone (PVP and Labrafil® M 2125 as carriers using the electrospray technique, and the effect of the carriers on drug solubility and solvation was assessed. The solid state characterization of an optimized formulation was conducted by scanning electron microscopy, powder X-ray diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopic analyses. Oral bioavailability in rats was also evaluated for the formulation of an optimized nanospherule in comparison with free drug and a conventional fenofibrate-loaded solid dispersion.Results: All of the electrosprayed nanospherule formulations had remarkably enhanced aqueous solubility and dissolution compared with free drug. Moreover, Labrafil M 2125, a surfactant, had a positive influence on the solubility and dissolution of the drug in the electrosprayed nanospherule. Increases were observed as the PVP/drug ratio increased to 4:1, but higher ratios gave no significant increases. In particular, an electrosprayed nanospherule composed of fenofibrate, PVP, and Labrafil M 2125 at the weight ratio of 1

[KIM-1 and NGAL as potential biomarkers for the diagnosis and cancer progression].

Science.gov (United States)

Marchewka, Zofia; Tacik, Aneta; Piwowar, Agnieszka

2016-04-18

On the basis of scientific literature, there is growing evidence that KIM-1 and NGAL are interesting and promising biomarkers not only in acute and chronic inflammatory processes but also in oncogenesis. There are a number of studies which investigate their possible use in diagnosis, treatment and monitoring of therapy effectiveness. The results of recent research suggests that they may play an important role in standard oncology practice. Simultaneous measurement of KIM-1 and NGAL in urine can play a crucial role in carcinogenesis assessment and cancer progression. In the future, they can become rapid diagnostic indicators, which allow one to determine cancer subtype leading to biopsy replacement and therapy improvement. In the present work, beside biochemical characteristics of KIM-1 and NGAL, we will also discuss their role in the diagnosis and assessment of development of cancer.

KIM-1 and NGAL as potential biomarkers for the diagnosis and cancer progression

Directory of Open Access Journals (Sweden)

Zofia Marchewka

2016-04-01

Full Text Available On the basis of scientific literature, there is growing evidence that KIM-1 and NGAL are interesting and promising biomarkers not only in acute and chronic inflammatory processes but also in oncogenesis. There are a number of studies which investigate their possible use in diagnosis, treatment and monitoring of therapy effectiveness. The results of recent research suggests that they may play an important role in standard oncology practice. Simultaneous measurement of KIM-1 and NGAL in urine can play a crucial role in carcinogenesis assessment and cancer progression. In the future, they can become rapid diagnostic indicators, which allow one to determine cancer subtype leading to biopsy replacement and therapy improvement. In the present work, beside biochemical characteristics of KIM-1 and NGAL, we will also discuss their role in the diagnosis and assessment of development of cancer.

Design of a gelatin microparticle-containing self-microemulsifying formulation for enhanced oral bioavailability of dutasteride

Directory of Open Access Journals (Sweden)

Baek I

2015-06-01

Full Text Available In-hwan Baek,1,* Eun-Sol Ha,2,* Jin-Wook Yoo,2 Yunjin Jung,2 Min-Soo Kim21College of Pharmacy, Kyungsung University, 2College of Pharmacy, Pusan National University, Busan, Republic of Korea*These authors contributed equally to this workAbstract: In this study, a gelatin microparticle-containing self-microemulsifying formulation (SMF was developed using a spray-drying method to enhance the oral delivery of the poorly water-soluble therapeutic dutasteride. The effect of the amount of gelatin and the type and amount of hydrophilic additives, namely, Gelucire® 44/14, poloxamer 407, sodium lauryl sulfate, Soluplus®, Solutol™ HS15, and D-α-tocopheryl polyethylene glycol 1000 succinate, on the droplet size, dissolution, and oral absorption of dutasteride from the SMF was investigated. Upon dispersion of the gelatin microparticle-containing SMF in water after spray-drying, the mean droplet size of the aqueous dispersion was in the range of 110–137 nm. The in vitro dissolution and recrystallization results showed that gelatin could be used as a solid carrier and recrystallization inhibitor for the SMF of dutasteride. Furthermore, combination of the gelatin microparticle-containing SMF and Soluplus enhanced the dissolution properties and oral absorption of dutasteride. The results of our study suggest that the gelatin microparticle-containing SMF in combination with Soluplus could be useful to enhance the oral absorption of dutasteride.Keywords: dissolution, solubility, bioavailability, dutasteride

Increased therapeutic efficacy of a newly synthesized tyrosinase inhibitor by solid lipid nanoparticles in the topical treatment of hyperpigmentation

Directory of Open Access Journals (Sweden)

Al-Amin M

2016-12-01

Full Text Available Md Al-Amin, Jiafu Cao, Muhammad Naeem, Hasanul Banna, Min-Soo Kim, Yunjin Jung, Hae Young Chung, Hyung Ryong Moon, Jin-Wook Yoo College of Pharmacy, Pusan National University, Busan, South Korea Abstract: Hyperpigmentation caused by melanin overproduction is a major skin disorder in humans. Inhibition of tyrosinase, a key regulator of melanin production, has been used as an effective strategy to treat hyperpigmentation. In this study, we investigated the use of solid lipid nanoparticles (SLNs as a highly effective and nontoxic means to deliver a newly synthesized potent tyrosinase inhibitor, MHY498, and to target melanocytes through the skin. MHY498-loaded SLNs (MHY-SLNs were prepared by an oil-in-water emulsion solvent-evaporation method, and their morphological and physicochemical properties were characterized. MHY-SLNs showed a prolonged drug-release profile and higher skin permeation than that of MHY solution. In an in vivo evaluation of antimelanogenic activity, MHY-SLNs showed a prominent inhibitory effect against ultraviolet B-induced melanogenesis, resulting in no change in the skin color of C57BL/6 mouse, compared with that observed in an MHY solution-treated group and an untreated control group. The antimelanogenic effect of MHY-SLNs was further confirmed through Fontana–Masson staining. Importantly, MHY-SLNs did not induce any toxic effects in the L929 cell line. Overall, these data indicate that MHY-SLNs show promise in the topical treatment of hyperpigmentation. Keywords: melanogenesis, hyperpigmentation, MHY498, solid lipid nanoparticles, skin delivery

Comparative analysis of nanotechnology awareness in consumers and experts in South Korea

Directory of Open Access Journals (Sweden)

Kim YR

2014-12-01

Full Text Available Yu-Ri Kim,1 Eun Jeong Lee,1 Sung Ha Park,2 Hyo Jin Kwon,3 Seong Soo A An,4 Sang Wook Son,5 Young Rok Seo,6 Jae-Eun Pie,7 Myoung Yoon,8 Ja Hei Kim,8 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Department of Medical Education, Korea University Medical School and College, Seoul, South Korea; 4Department of Bionanotechnology, Gachon University, Seongnam, Gyeonggi, South Korea; 5Department of Dermatology, Korea University Medical School and College, Seoul, South Korea; 6Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, South Korea; 7Department of Food and Nutrition, College of Science and Engineering, Anyang University, Anyang, Gyeonggi, South Korea; 8Consumers Korea, Seoul, South Korea Purpose: This study examined the need for public communication about nanotechnologies and nanoparticles by providing a comparative analysis of the differences in risk awareness of nanotechnologies and nanoparticles between consumers and experts. Methods: A total of 1,007 consumers and 150 experts participated in this study. A questionnaire was prepared examining their awareness of nanotechnologies and nanomaterials and their view of the necessity for information and education about the latest nanotechnologies and nanomaterials. Results: Our results indicated that the expert group recognized that they knew more than consumers about nanotechnology and that there was a need for relevant education in nanotechnology and nanomaterials among consumers. We found that the consumer group had a more positive attitude toward nanotechnology, even though they did not know much about it. Moreover, the consumer group was inconclusive about the type of information on nanotechnology deemed necessary for the public, as well as the suitable party to be responsible for education

Interactive survey of consumer awareness of nanotechnologies and nanoparticles in consumer products in South Korea

Directory of Open Access Journals (Sweden)

Kim YR

2014-12-01

Full Text Available Yu-Ri Kim,1 Eun Jeong Lee,1 Sung Ha Park,2 Hyo Jin Kwon,3 Seong Soo A An,4 Sang Wook Son,5 Young Rok Seo,6 Jae-Eun Pie,7 Myoung Yoon,8 Ja Hei Kim,8 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Department of Medical Education, Korea University Medical School and College, Seoul, South Korea; 4Department of Bionanotechnology, Gachon University, Seongnam, South Korea; 5Department of Dermatology, Korea University Medical School and College, 6Department of Life Science, Institute of Environmental Medicine for Green Chemistry, Dongguk University, Seoul, South Korea; 7Department of Food and Nutrition, College of Science and Engineering, Anyang University, Anyang, Korea; 8Consumers Korea, Seoul, South Korea Background: The purpose of our study was to understand consumers' risk awareness and need for relevant information about nanotechnology and nanoparticles contained in products currently being sold in Korea. Methods: One thousand and seven adult consumers (aged 20–50 years were randomly selected from all over South Korea between November 1 and 9, 2010. We surveyed the origin and degree of their concern and their need for information and education regarding nanomaterials. Results: Analysis of the survey results showed no significant differences in responses by sex, age, and level of education, but significant differences were found in responses based on average monthly household income. Our research showed that consumers have vague expectations for and positive image of nanotechnology and nanoproducts but do not clearly understand what they are. In addition, we found that preparing and disseminating information to consumers is required in order to provide correct information about nanotechnology to the public. Conclusion: A communication system should be established among the multiple stakeholders involved

The Impact of Land Use and Land Cover Change on Water Yield in the Jing- Jin-Ji Region in China

Science.gov (United States)

Li, Suxiao; Yang, Hong

2017-04-01

Water yield is one of the key ecosystem services sustaining both people's life and economic development. However, the water yield function is sensitive to anthropogenic activity especially the land use and land cover change (LUCC). Assessment of historical LUCC and its impact on water yield could benefit designing and implementing appropriate land use strategy that enhance the water yield capacity. Beijing (Jing) and its surrounding areas of Tianjin (Jin) and Hebei (Ji) is the political, cultural and economic center of China. The region is facing increasingly water crisis. Taking the Jing-Jin-Ji region as a study area, this study analyzed the historical LUCC and its impact on water yield by using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST) model to spatially map and quantify the changes of water yield from 1995 to 2010. The results showed there was main decline in area of wetland and forest and increase in area of crop land and built up land. An abrupt decline in water yield was found for year 2000. The water yield was influenced to a great extent by precipitation and evapotranspiration, but the land use played an important role in the water yield capacity (water yield per unit area) through plant cover that affected evapotranspiration, soil water permeability and the capacity of holding the moisture content. By general ranking, the water yield capacity of different land use type was as follows: built-up>bare land>cropland> grassland>forest >wetland, which illustrated that the built-up and bare land had higher run off rate while the vegetation area had higher capacity to control surface run off to increase the groundwater. A good understanding of temporal-spatial allocation of historical LUCC and Water yield of the Jing-Jin-Ji region could help guide land use policy decisions that take into consideration of tradeoffs with respect to spatial distribution of ecosystem services amongst the three administrative entities (Jing-Jin-Ji) and

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

OpenAIRE

Oh, Keun Sang; Kim, Kyungim; Yoon, Byeong Deok; Lee, Hye Jin; Park, Dal Yong; Kim, Eun-yeong; Lee, Kiho; Seo, Jae Hong; Yuk, Soon Hong

2016-01-01

Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A mixture of docetaxel (DTX) and Solutol® HS 15 (Solutol) transiently formed nanodroplets when it was suspended in an aqueous medium. However, n...

Pharmacokinetic and bioequivalence study of a telmisartan/S-amlodipine fixed-dose combination (CKD-828) formulation and coadministered telmisartan and S-amlodipine in healthy subjects

OpenAIRE

Kang,Woo Youl; Seong,Sook Jin; Ohk,Boram; Gwon,Mi-Ri; Kim,Bo Kyung; La,Sookie; Kim,Hyun-Ju; Cho,Seungil; Yoon,Young-Ran; Yang,Dong Heon; Lee,Hae Won

2018-01-01

Woo Youl Kang,1,2,* Sook Jin Seong,1,* Boram Ohk,1,2 Mi-Ri Gwon,1,3 Bo Kyung Kim,1,2 Sookie La,4 Hyun-Ju Kim,3 Seungil Cho,1 Young-Ran Yoon,1,2 Dong Heon Yang,5 Hae Won Lee1 1Clinical Trial Center, Kyungpook National University Hospital, Daegu, Republic of Korea; 2Department of Biomedical Science, BK21 Plus KNU Bio-Medical Convergence Program for Creative Talent, Kyungpook National University Graduate School, Daegu, Republic of Korea; 3Department of Molecular Medicine, Cell and Matrix Resear...

North Korean Leadership Dynamics and Decision-making under Kim Jong-un: A Second Year Assessment

Science.gov (United States)

2014-03-01

Kim Kyong-hui was critically ill. Kim has a reported history of alcoholism and depression , which was exacerbated in the mid-2000s with her mari- tal...problems and the death of her daughter, Jang Kum-song, who com- mitted suicide in 2006. Some reports claim that she is also suffering from... teens , were

New Nordic Exceptionalism: Jeuno JE Kim and Ewa Einhorn's The United Nations of Norden and other realist utopias

Directory of Open Access Journals (Sweden)

Mathias Danbolt

2016-11-01

Full Text Available At the 2009 Nordic Culture Forum summit in Berlin that centered on the profiling and branding of the Nordic region in a globalized world, one presenter stood out from the crowd. The lobbyist Annika Sigurdardottir delivered a speech that called for the establishment of “The United Nations of Norden”: A Nordic union that would gather the nations and restore Norden's role as the “moral superpower of the world.” Sigurdardottir's presentation generated such a heated debate that the organizers had to intervene and reveal that the speech was a performance made by the artists Jeuno JE Kim and Ewa Einhorn. This article takes Kim and Einhorn's intervention as a starting point for a critical discussion of the history and politics of Nordic image-building. The article suggests that the reason Kim and Einhorn's speech passed as a serious proposal was due to its meticulous mimicking of two discursive formations that have been central to the debates on the branding of Nordicity over the last decades: on the one hand, the discourse of “Nordic exceptionalism,” that since the 1960s has been central to the promotion of a Nordic political, socio-economic, and internationalist “third way” model, and, on the other hand, the discourse on the “New Nordic,” that emerged out of the New Nordic Food-movement in the early 2000s, and which has given art and culture a privileged role in the international re-fashioning of the Nordic brand. Through an analysis of Kim and Einhorn's United Nations of Norden (UNN-performance, the article examines the historical development and ideological underpinnings of the image of Nordic unity at play in the discourses of Nordic exceptionalism and the New Nordic. By focusing on how the UNN-project puts pressure on the role of utopian imaginaries in the construction of Nordic self-images, the article describes the emergence of a discursive framework of New Nordic Exceptionalism.

Lõuna-Korea teatel võib Kim peagi surra / Evelyn Kaldoja

Index Scriptorium Estoniae

Kaldoja, Evelyn, 1980-

2009-01-01

Viidates Lõuna-Korea ja Hiina luureandmetele, väidab Lõuna-Korea meedia, et Põhja-Korea liidril Kim Jong-ilil on kõhunäärmevähk ja talle pole antud elada rohkem kui 5 aastat. Põhja-Korea valitsejadünastia

Monte Carlo lattice program KIM

International Nuclear Information System (INIS)

Cupini, E.; De Matteis, A.; Simonini, R.

1980-01-01

The Monte Carlo program KIM solves the steady-state linear neutron transport equation for a fixed-source problem or, by successive fixed-source runs, for the eigenvalue problem, in a two-dimensional thermal reactor lattice. Fluxes and reaction rates are the main quantities computed by the program, from which power distribution and few-group averaged cross sections are derived. The simulation ranges from 10 MeV to zero and includes anisotropic and inelastic scattering in the fast energy region, the epithermal Doppler broadening of the resonances of some nuclides, and the thermalization phenomenon by taking into account the thermal velocity distribution of some molecules. Besides the well known combinatorial geometry, the program allows complex configurations to be represented by a discrete set of points, an approach greatly improving calculation speed

Compound mitochondrial DNA mutations in a neurological patient ...

Indian Academy of Sciences (India)

Compound mitochondrial DNA mutations in a neurological patient with ataxia, myoclonus and deafness. Ji Hoon Park, Bo Ram Yoon, Hye Jin Kim, Phil Hyu Lee, Byung-Ok Choi and Ki Wha Chung. J. Genet. 93, 173–177. Table 1. Variations from the whole mtDNA sequence in the AMDF patient. Mutation. Report. Locus/ ...

Safety assessment of silica and zinc oxide nanoparticles

OpenAIRE

An, Seong Soo A; Kim, Meyoung-Kon

2014-01-01

Seong Soo A An,1 Meyoung-Kon Kim2 1Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, Gyeonggi, Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, KoreaThe current volume is a special issue focusing on a safety assessment of nanoparticles, from their physicochemical properties to government regulations. It features twenty-five papers, discussing general issues with the possible harmfulness...

Against the Nihilism of Suffering and Death: Richard E. K. Kim and His Works

Directory of Open Access Journals (Sweden)

Jooyeon Rhee

2016-03-01

Full Text Available This article examines the life and works of Richard E. K. Kim (1932–2009, a first-generation Korean diasporic writer in the United States. It focuses on how Kim struggled to overcome the nihilism of suffering and death that derived from colonialism and the Korean War through his literary works. Kim witnessed firsthand these two major historical events, which caused irrevocable psychological and physical damage to many people of his generation. In his autobiographical fiction, he conveys painful memories of the events by reviving the voices of people in that era. What his works offer us goes beyond vivid memories of the past, however; they also present the power of forgiveness as a condition to overcome the nihilism of suffering and death. Remembrance and forgiveness are, therefore, two major thematic pillars of his works that enable us to connect to these difficult and traumatic times. These themes are portrayed in such a gripping way mainly because Kim tried to maintain a certain distance—an emotional and linguistic distance—from the familiar, in order to elucidate the reality of the human condition: an ontological position of the exile from which he produced his works. This article argues that Kim’s works provide us the possibility to transcend the nihilism of historical trauma through articulating the meaning of remembrance and forgiveness from his self-assumed position of exile.

Global Policing and the Case of Kim Dotcom

OpenAIRE

Darren Palmer; Ian J Warren

2013-01-01

In early 2012, 76 heavily armed police conducted a raid on a house in Auckland, New Zealand. The targets were Kim Dotcom, a German national with a NZ residency visa, and several colleagues affiliated with Megaupload, an online subscription-based peer-to-peer (P2P) file sharing facility. The alleged offences involved facilitating unlawful file sharing and United States federal criminal copyright violations. Following the raid, several court cases provide valuable insights into emerging ‘global...

The impact of the "Air Pollution Prevention and Control Action Plan" on PM2.5 concentrations in Jing-Jin-Ji region during 2012-2020.

Science.gov (United States)

Cai, Siyi; Wang, Yangjun; Zhao, Bin; Wang, Shuxiao; Chang, Xing; Hao, Jiming

2017-02-15

In order to cope with heavy haze pollution in China, the Air Pollution Prevention and Control Action Plan including phased goals of the fine particulate matter (PM 2.5 ) was issued in 2013. In this study, China's emission inventories in the baseline 2012 and the future scenarios of 2017 and 2020 have been developed based on this Action Plan. Beijing-Tianjin-Hebei (Jing-Jin-Ji) region, one of the most polluted regions in China, was taken as a case to assess the impact of phased emission control measures on PM 2.5 concentration reduction using WRF-CMAQ model system. With the implementation of the Action Plan, the emissions of sulfur dioxide (SO 2 ), nitrogen oxides (NO X ) , PM 2.5 , non-methane volatile organic compound (NMVOC), and ammonia (NH 3 ) in 2017 will decrease by36%, 31%, 30%,12%, and -10% from the 2012 levels in Jing-Jin-Ji, respectively. In 2020, the emissions of SO 2 , NO X, PM 2.5 , NMVOC, and NH 3 will decrease by 40%, 44%, 40%, 22%, and -3% from the 2012 levels in Jing-Jin-Ji, respectively. Consequently, the ambient annual PM 2.5 concentration under the scenarios of 2017 and 2020 will be 28.3% and 37.8% lower than those in 2012, respectively. The Action Plan provided an effective approach to alleviate PM 2.5 pollution level in Jing-Jin-Ji region. However, emission control of NMVOC and NH 3 should be paid more attention and be strengthened in future. Meanwhile, emission control of NO x , SO 2 , NH 3 and NMVOC synergistically are highly needed in the future because multiple pollutants impact on PM 2.5 and O 3 concentrations nonlinearly. Copyright © 2016 Elsevier B.V. All rights reserved.

Ab initio and Gordon--Kim intermolecular potentials for two nitrogen molecules

International Nuclear Information System (INIS)

Ree, F.H.; Winter, N.W.

1980-01-01

Both ab initio MO--LCAO--SCF and the electron-gas (or Gordon--Kim) methods have been used to compute the intermolecular potential (Phi) of N 2 molecules for seven different N 2 --N 2 orientations. The ab initio calculations were carried out using a [4s3p] contracted Gaussian basis set with and without 3d polarization functions. The larger basis set provides adequate results for Phi>0.002 hartree or intermolecular separations less than 6.5--7 bohr. We use a convenient analytic expression to represent the ab initio data in terms of the intermolecular distance and three angles defining the orientations of the two N 2 molecules. The Gordon--Kim method with Rae's self-exchange correction yields Phi, which agrees reasonably well over a large repulsive range. However, a detailed comparison of the electron kinetic energy contributions shows a large difference between the ab initio and the Gordon--Kim calculations. Using the ab initio data we derive an atom--atom potential of the two N 2 molecules. Although this expression does not accurately fit the data at some orientations, its spherical average agrees with the corresponding average of the ab initio Phi remarkably well. The spherically averaged ab initio Phi is also compared with the corresponding quantities derived from experimental considerations. The approach of the ab initio Phi to the classical quadrupole--quadrupole interaction at large intermolecular separation is also discussed

Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Directory of Open Access Journals (Sweden)

Ben Li

2017-01-01

Full Text Available Objective. To evaluate the clinical therapeutic efficacy and safety of JieDuTongLuoShengJin granules + HCQ in patients with pSS. Methods. 40 patients with low-activity-level pSS and without visceral involvement participated in this study and were randomized to receive either JieDuTongLuoShengJin granules with HCQ or placebo with HCQ. Patients and investigators were blinded to treatment allocation. The primary endpoint was week 12 ESSPRI score, while secondary endpoints included ESSDAI, salivary and lacrimal gland function, and some laboratory variables. Safety-related data were also assessed. Results. Comparing with the placebo group, the treatment group experienced statistically significant improvement in the mean change from baseline for the primary endpoint of ESSPRI score and also in PGA. Moreover, in comparison with baseline values, the treatment group had significantly improved ESSDAI score, unstimulated saliva flow rate, and several laboratory variables. However, upon comparison of the two groups, there were no significant differences for them. The incidence of AEs was 10.0%, one in treatment group and three in placebo group. Conclusion. Treatment with a combination of JieDuTongLuoShengJin granules with HCQ is effective in improving patients’ subjective symptoms and some objective indicators of pSS. These results indicate that JieDuTongLuoShengJin is promising as a safe and effective treatment of pSS.

Kim C. Sturgess. Shakespeare and the American Nation.

OpenAIRE

Claret, Jean‑Louis

2006-01-01

The front page of Kim C Sturgess’s recent book entitled Shakespeare and the American Nation is particularly mind‑teasing insofar as it represents the famous Droeshout engraving of the bard (it illustrated the front‑page of the 1623 edition of Shakespeare’s works) standing out against a background that superimposes the head of the Statue of Liberty on the spangled banner. The starting point of Sturgess’s 234‑page demonstration endorsed by Cambridge University Press is a paradox that the Britis...

Urinary NGAL, KIM-1 and L-FABP concentrations in antenatal hydronephrosis.

Science.gov (United States)

Noyan, Aytul; Parmaksiz, Gonul; Dursun, Hasan; Ezer, Semire Serin; Anarat, Ruksan; Cengiz, Nurcan

2015-10-01

The clinical tests currently in use for obstructive nephropathy (such as renal ultrasonography, differential radionuclide renal scans and urinary creatinine concentration data) are not efficient predictors of the subsequent clinical course. Novel and simple biomarkers are required which, if proven, could be clinically beneficial in determining if a patient is eligible for surgery or reno-protective therapy. More recently, the interest of clinicians has focused on the potential of urinary neutrophil gelatinase-associated lipocalin (uNGAL), urinary kidney injury molecule-1 (uKIM-1) and urinary liver-type fatty acid-binding proteins (uL-FABP) as biomarkers for renal function in children with hydronephrosis (HN). The purpose of this study was to investigate possible clinical applications of uNGAL, uKIM-1 and uL-FABP as beneficial non-invasive biomarkers to determine whether or not surgical intervention is required in children with HN. Renal ultrasonography and radionuclide renal scans were used as diagnostic tools to detect HN. Patients were divided into two groups based on the antero-posterior diameter of their renal pelvis and the presence of dysfunction. Group 1 included 26 children with severe HN (with dysfunction), and group 2 consisted of 36 children with mild HN (without dysfunction). Urine samples were collected from 62 children with HN and 20 healthy children. Hydronephrosis was more common in males than in females, with a male to female ratio of 9:1 in the study sample. The incidence of left kidney involvement (32 patients) was slightly higher than right kidney involvement (28 patients). Compared with controls and group 2, the ratio of uNGAL to creatinine was significantly higher in group 1 (p hydronephrosis and dysfunction had significantly increased uNGAL, and uNGAL/Cr concentrations. However, uKIM-1, uKIM-1/Cr, uL-FABP and uL-FABP/Cr concentrations were not significantly different when compared with controls. These results support the use of u

Delivery of bone morphogenetic protein-2 and substance P using graphene oxide for bone regeneration

Directory of Open Access Journals (Sweden)

La WG

2014-05-01

Full Text Available Wan-Geun La,1 Min Jin,1 Saibom Park,1,2 Hee-Hun Yoon,1 Gun-Jae Jeong,1 Suk Ho Bhang,1 Hoyoung Park,1,2 Kookheon Char,1,2 Byung-Soo Kim1,31School of Chemical and Biological Engineering, Seoul National University, Seoul, Republic of Korea; 2The National Creative Research Initiative Center for Intelligent Hybrids, Seoul National University, Seoul, Republic of Korea; 3Institute of Bioengineering, Institute of Chemical Processes, Engineering Research Institute, Seoul National University, Seoul, Republic of KoreaAbstract: In this study, we demonstrate that graphene oxide (GO can be used for the delivery of bone morphogenetic protein-2 (BMP-2 and substance P (SP, and that this delivery promotes bone formation on titanium (Ti implants that are coated with GO. GO coating on Ti substrate enabled a sustained release of BMP-2. BMP-2 delivery using GO-coated Ti exhibited a higher alkaline phosphatase activity in bone-forming cells in vitro compared with bare Ti. SP, which is known to recruit mesenchymal stem cells (MSCs, was co-delivered using Ti or GO-coated Ti to further promote bone formation. SP induced the migration of MSCs in vitro. The dual delivery of BMP-2 and SP using GO-coated Ti showed the greatest new bone formation on Ti implanted in the mouse calvaria compared with other groups. This approach may be useful to improve osteointegration of Ti in dental or orthopedic implants.Keywords: bone morphogenetic protein-2, bone regeneration, graphene oxides, stem cell recruitment, substance P

Consumption-based Total Suspended Particulate Matter Emissions in Jing-Jin-Ji Area of China

Science.gov (United States)

Yang, S.; Chen, S.; Chen, B.

2014-12-01

The highly-industrialized regions in China have been facing a serious problem of haze mainly consisted of total suspended particulate matter (TSPM), which has attracted great attention from the public since it directly impairs human health and clinically increases the risks of various respiratory and pulmonary diseases. In this paper, we set up a multi-regional input-output (MRIO) model to analyze the transferring routes of TSPM emissions between regions through trades. TSPM emission from particulate source regions and sectors are identified by analyzing the embodied TSPM flows through monetary flow and carbon footprint. The track of TSPM from origin to end via consumption activities are also revealed by tracing the product supply chain associated with the TSPM emissions. Beijing-Tianjin-Hebei (Jing-Jin-Ji) as the most industrialized area of China is selected for a case study. The result shows that over 70% of TSPM emissions associated with goods consumed in Beijing and Tianjin occurred outside of their own administrative boundaries, implying that Beijing and Tianjin are net embodied TSPM importers. Meanwhile, 63% of the total TSPM emissions in Hebei Province are resulted from the outside demand, indicating Hebei is a net exporter. In addition, nearly half of TSPM emissions are the by-products related to electricity and heating supply and non-metal mineral products in Jing-Jin-Ji Area. Based on the model results, we provided new insights into establishing systemic strategies and identifying mitigation priorities to stem TSPM emissions in China. Keywords: total suspended particulate matter (TSPM); urban ecosystem modeling; multi-regional input-output (MRIO); China

The 3rd international conference on reproductive immunology in Shanghai: September 27-29, 2013. Shanghai, China.

Science.gov (United States)

Du, MeiRong; Piao, HaiLan; Li, DaJin

2014-03-01

After the first and second international conferences on reproductive immunology held by Dr. DaJin Li in Shanghai, the related investigators all over the world hope to get together to share their latest findings with each other. Drs. DaJin Li and MeiRong Du sponsored and organized the third international conference on reproductive immunology at the Obstetrics and Gynecology Hospital affiliated with Fudan University, Shanghai, China, in the autumn of 2013. This congress brought together more than 100 International and National investigators representing a wide range of scientific disciplines. All the investigators actively work on reproductive immunology using human or large and small animal models. A range of reproductive immunological topics including the maternal-fetal immune regulation, reproductive tract mucosal immunology, immunocontraception, and pregnancy complications were highlighted and discussed in this conference. This conference supplied a good platform for the international reproductive immunologists to exchange their latest study progression and discuss the development direction of reproductive immunology in the near future. © 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Kim C. Sturgess. Shakespeare and the American Nation.

Directory of Open Access Journals (Sweden)

Jean‑Louis Claret

2006-04-01

Full Text Available The front page of Kim C Sturgess’s recent book entitled Shakespeare and the American Nation is particularly mind‑teasing insofar as it represents the famous Droeshout engraving of the bard (it illustrated the front‑page of the 1623 edition of Shakespeare’s works standing out against a background that superimposes the head of the Statue of Liberty on the spangled banner. The starting point of Sturgess’s 234‑page demonstration endorsed by Cambridge University Press is a paradox that the Britis...

The first clinical treatment with kilovoltage intrafraction monitoring (KIM): A real-time image guidance method

DEFF Research Database (Denmark)

Keall, Paul J.; Aun Ng, Jin; O'Brien, Ricky

2015-01-01

on September 16, 2014. Methods: KIM uses current and prior 2D x-ray images to estimate the 3D target position during cancer radiotherapy treatment delivery. KIM software was written to process kilovoltage (kV) images streamed from a standard C-arm linear accelerator with a gantry-mounted kV x-ray imaging...... system. A 120° pretreatment kV imaging arc was acquired to build the patient-specific 2D to 3D motion correlation. The kV imager was activated during the megavoltage (MV) treatment, a dual arc VMAT prostate treatment, to estimate the 3D prostate position in real-time. All necessary ethics, legal......, and regulatory requirements were met for this clinical study. The quality assurance processes were completed and peer reviewed. Results: During treatment, a prostate position offset of nearly 3 mm in the posterior direction was observed with KIM. This position offset did not trigger a gating event. After...

[Recent books on international law] / Yoonie Kim, Paul R Williams

Index Scriptorium Estoniae

Kim, Yoonie

2005-01-01

Arvustus: Lauri Mälksoo. Illegal Annexation and State Continuity : The Case of the Incorporation of the Baltic States by the USSR. Study of the Tension between Normativity and Power in International Law. Leiden ; Boston, 2003

People who live for quality

International Nuclear Information System (INIS)

1995-03-01

This book introduces the case of model of quality management. There are a lot of titles and people's example such as with dogged perseverance by Kang, Beom Sik in SK industry, come back to company which he submitted his resignation by Kim, Byeong Hui in Hyundai Heavy industries, I want to be the world best by Yeon, Sang Jin in Geum Ho industry, a good beginning is half the battle by Kwon, Bok Sik in KIA company, employee satisfaction is quality management by Hong, Sun Gyeom, in Dong Yang piston, and praying for all by Kim, Youn Ja in Lotte department store.

The diagnostic importance of the new marker KIM-1 in kidney damage

Directory of Open Access Journals (Sweden)

Zofia Marchewka

2013-07-01

Full Text Available In recent years, the rapid development of scientific research led to the introduction of strategies based on new markers that allow for estimation of the latent disease period before the clinical symptoms of actual kidney failure are revealed.The experimental tests carried out on animals and cell lines derived from the proximal tubule have made possible the detection of genes that are induced early after hypoxia [1].The protein products of these genes can be considered as useful markers for the diagnosis of renal failure. The induction of gene KIM-1 (called Kidney Injury Molecule-1 results in the formation of protein that can be considered as a diagnostic marker.This work describes the data on the structure, biological function and importance of determining the concentrations of KIM-1 in the diagnosis of drug-induced toxicity and kidney damage.

[The diagnostic importance of the new marker KIM-1 in kidney damage].

Science.gov (United States)

Marchewka, Zofia; Płonka, Joanna

2013-07-24

In recent years, the rapid development of scientific research led to the introduction of strategies based on new markers that allow for estimation of the latent disease period before the clinical symptoms of actual kidney failure are revealed. The experimental tests carried out on animals and cell lines derived from the proximal tubule have made possible the detection of genes that are induced early after hypoxia. The protein products of these genes can be considered as useful markers for the diagnosis of renal failure. The induction of gene KIM-1 (called Kidney Injury Molecule-1) results in the formation of protein that can be considered as a diagnostic marker. This work describes the data on the structure, biological function and importance of determining the concentrations of KIM-1 in the diagnosis of drug-induced toxicity and kidney damage.

Panel discussion on rock mechanics issues in repository design

International Nuclear Information System (INIS)

Bieniawski, Z.T.; Kim, K.S.; Nataraja, M.

1996-01-01

The panel discussion was introduced by Mr. Z.T.(Richard) Bieniawski and then continued with five additional speakers. The topics covered in the discussion included rock mechanics pertaining to the design of underground facilities for the disposal of radioactive wastes and the safety of such facilities. The speakers included: Mr. Kun-Soo Kim who is a specialist in the area of rock mechanics testing during the Basalt Waste Isolation Project; Dr. Mysore Nataraja who is the senior project manager with the NRC; Dr. Michael Voegele who is the project manager for Science Applications International Corporation (SAIC) on the Yucca Mountain Project; Dr. Edward Cording who is a member of the Nuclear Waste Technical Review Board; and Dr. Hemendra Kalia who is employed by Los Alamos National Laboratory and coordinates various activities of testing programs at the Yucca Mountain Site

Safety assessment of silica and zinc oxide nanoparticles

Directory of Open Access Journals (Sweden)

An SSA

2014-12-01

Full Text Available Seong Soo A An,1 Meyoung-Kon Kim2 1Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, Gyeonggi, Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, KoreaThe current volume is a special issue focusing on a safety assessment of nanoparticles, from their physicochemical properties to government regulations. It features twenty-five papers, discussing general issues with the possible harmfulness of two different types of nanoparticles (NPs; silica (SiO2 and zinc oxide (ZnO. Six papers describe detailed analyses from 90-day repeated administrations of NPs, and finally there is a series of technical reports, formatted by the National Toxicology Program (NTP, dealing with safety issues regarding international cooperation with the OECD (Organisation for Economic Co-operation and Development Working Party on Manufactured Nanomaterials (WPMN.

Isoeugenol monooxygenase and its putative regulatory gene are located in the eugenol metabolic gene cluster in Pseudomonas nitroreducens Jin1.

Science.gov (United States)

Ryu, Ji-Young; Seo, Jiyoung; Unno, Tatsuya; Ahn, Joong-Hoon; Yan, Tao; Sadowsky, Michael J; Hur, Hor-Gil

2010-03-01

The plant-derived phenylpropanoids eugenol and isoeugenol have been proposed as useful precursors for the production of natural vanillin. Genes involved in the metabolism of eugenol and isoeugenol were clustered in region of about a 30 kb of Pseudomonas nitroreducens Jin1. Two of the 23 ORFs in this region, ORFs 26 (iemR) and 27 (iem), were predicted to be involved in the conversion of isoeugenol to vanillin. The deduced amino acid sequence of isoeugenol monooxygenase (Iem) of strain Jin1 had 81.4% identity to isoeugenol monooxygenase from Pseudomonas putida IE27, which also transforms isoeugenol to vanillin. Iem was expressed in E. coli BL21(DE3) and was found to lead to isoeugenol to vanillin transformation. Deletion and cloning analyses indicated that the gene iemR, located upstream of iem, is required for expression of iem in the presence of isoeugenol, suggesting it to be the iem regulatory gene. Reverse transcription, real-time PCR analyses indicated that the genes involved in the metabolism of eugenol and isoeugenol were differently induced by isoeugenol, eugenol, and vanillin.

Tissue distribution and excretion kinetics of orally administered silica nanoparticles in rats

Directory of Open Access Journals (Sweden)

Lee JA

2014-12-01

Full Text Available Jeong-A Lee,1 Mi-Kyung Kim,1 Hee-Jeong Paek,1 Yu-Ri Kim,2 Meyoung-Kon Kim,2 Jong-Kwon Lee,3 Jayoung Jeong,3 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, Republic of Korea; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk–do, Republic of Korea Purpose: The effects of particle size on the tissue distribution and excretion kinetics of silica nanoparticles and their biological fates were investigated following a single oral administration to male and female rats. Methods: Silica nanoparticles of two different sizes (20 nm and 100 nm were orally administered to male and female rats, respectively. Tissue distribution kinetics, excretion profiles, and fates in tissues were analyzed using elemental analysis and transmission electron microscopy. Results: The differently sized silica nanoparticles mainly distributed to kidneys and liver for 3 days post-administration and, to some extent, to lungs and spleen for 2 days post-administration, regardless of particle size or sex. Transmission electron microscopy and energy dispersive spectroscopy studies in tissues demonstrated almost intact particles in liver, but partially decomposed particles with an irregular morphology were found in kidneys, especially in rats that had been administered 20 nm nanoparticles. Size-dependent excretion kinetics were apparent and the smaller 20 nm particles were found to be more rapidly eliminated than the larger 100 nm particles. Elimination profiles showed 7%–8% of silica nanoparticles were excreted via urine, but most nanoparticles were excreted via feces, regardless of particle size or sex. Conclusion: The kidneys, liver, lungs, and spleen were found to be the target organs of orally-administered silica nanoparticles in rats, and this organ

Kim Wŏn-haeng’s Intellectual Influences on Hong Tae-yong: The Case of Relations between

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Login Lok-yin Law

2015-08-01

Full Text Available In the 18th century Chosŏn (1392-1910, some scholars, such as Hong Tae-yong (1731-1783 advocated that Chosŏn should learn the advantages of the Qing (1644-1912 society to reform the social structure and government of Chosŏn. The school of these advocates has been known as Pukhak by historians. The intellectual factors of the school of Pukhak’s formation and development have been overlooked by the academia of Chosŏn intellectual history. In fact, Pukhak was closely related to the idea of the school of Nakhak which believed that nature of things was equivalent to humans. Kim Wŏn-haeng, was one of the supporters of Nakhak and Hong Tae-yong was one of the students of Kim. Hong’s thought and writing exposed that his thought was profoundly influenced by Kim Wŏn-haeng. Hong was deemed to be the first prominent scholar of the Pukhak School during the 18th century Chosŏn. Hong and other scholars of Pukhak advocated learning the new knowledge from Qing China even though it was a barbarian society. Therefore, this paper will investigate the intellectual relationships between Hong Tae-yong and Kim Wŏn-haeng to reveal how intellectuals of Nakhak shaped the formation of Pukhak School and exposed the idea of learning from Qing China.

Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

OpenAIRE

Han, Jae Woong; Gurunathan, Sangiliyandi; Choi, Yun-Jung; Kim, Jin-Hoi

2017-01-01

Jae Woong Han, Sangiliyandi Gurunathan, Yun-Jung Choi, Jin-Hoi Kim Department of Stem Cell and Regenerative Biotechnology, Humanized Pig Research Center (SRC), Konkuk University, Seoul, Republic of Korea Background: Silver nanoparticles (AgNPs) exhibit strong antibacterial and anticancer activity owing to their large surface-to-volume ratios and crystallographic surface structure. Owing to their various applications, understanding the mechanisms of action, biological interactions, potential...

Iklan Sebagai Media Kritik Sosial (Pesan Simbolik Iklan Kretek Djarum 76 Seri Jin

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Firdaus Azwar Ersyad

2016-04-01

Full Text Available The presence of television advertising is a prayer one way to manufacturer for review introduce and selling products for society. Regarding the regulation of advertising especially cigarettes and tobacco products manufacturer in order to encourage creative hearts introducing more on audience their product . As a result , the creativity in the hearts smoking ads aimed lifting product image so not operate direct products display .Singer study originated from the interest against visualization advertisements Djarum 76 series java jin  has its own peculiarities compared to other products . Zoom the one consolation is not revealed that an advertiser is selling products . Views are interpreted by different groups various ad viewers, but the views can be grouped into some basic ideas

[Status of diagnosis and treatment devices of acupuncture based on SooPAT and bibliometrics in China].

Science.gov (United States)

Bai, Lin; Ren, Yulan; Guo, Taipin; Chen, Lin; Zhou, Yumei; Feng, Shuwei; Li, Ji; Liang, Fanrong

2016-11-12

To perform a bibliometrics analysis on patent literature regarding diagnosis and treatment devices of acupuncture in China, aiming to provide references for the development of diagnosis and treatment devices of acupuncture. Based on SooPAT, a patent database, the patent literature regarding diagnosis and treatment devices of acupuncture in China was collected. With bibliometrics methods, the annual distribution of type, quantity, classification and content of diagnosis and treatment devices of acupuncture were analyzed. The number of acupuncture diagnosis and treatment devices reached its peak in 2012 and 2013 in China. The A61N in patent and utility model patent were the most, which were mainly related to electrotherapy, magnetic therapy, radioactive therapy and ultrasound therapy, etc. The main content was acupuncture treatment devices and meridian treatment devices. The 24-01 in design patent was the most, involving fixation devices used by doctors, hospitals and laboratories, etc. Currently the majority of diagnosis and treatment devices of acupuncture is therapeutic apparatus, while the acupuncture diagnosis devices are needed.

Language and Family Dispersion: North Korean Linguist Kim Su-gyŏng and the Korean War

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Ryuta Itagaki

2017-03-01

Full Text Available This article analyzes the unpublished memoir of Kim Su-gyŏng (1918–2000, a linguist who was active in North Korea from the mid-1940s until the late 1960s, and situates his account of his experience of the Korean War within the context of his linguistic essays and correspondence. In doing so, the article considers the role that the personal and the social play in language, utilizing Saussure’s theoretical framework, with which Kim himself was well versed. Kim wrote his memoirs in the 1990s to his family, from whom he had become separated during the Korean War and who now lived in Toronto. In this text, he writes in “personal” language that reveals his uncertainty and his feelings for his family, but then immediately negates these feelings through the use of “social” language, which resonates with his interpretation of the linguistic thesis that Josef Stalin developed during the Korean War on language and national identity. For Kim, the relationship between language and nation was not at all self-evident, but something that he idealized in response to the dispersal of his family. By offering a reflexive reading of a memoir written by a North Korean linguist, this article makes a breakthrough in the investigation of North Korean wartime academic history, which has not risen above the level of analyzing articles in the field of linguistics that were published at the time.

Biokinetics of zinc oxide nanoparticles: toxicokinetics, biological fates, and protein interaction

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Choi SJ

2014-12-01

Full Text Available Soo-Jin Choi,1 Jin-Ho Choy2 1Department of Food Science and Technology, Seoul Women's University, 2Center for Intelligent Nano Bio Materials (CINBM, Department of Bioinspired Science and Department of Chemistry and Nanoscience, Ewha Womans University, Seoul, South Korea Abstract: Biokinetic studies of zinc oxide (ZnO nanoparticles involve systematic and quantitative analyses of absorption, distribution, metabolism, and excretion in plasma and tissues of whole animals after exposure. A full understanding of the biokinetics provides basic information about nanoparticle entry into systemic circulation, target organs of accumulation and toxicity, and elimination time, which is important for predicting the long-term toxic potential of nanoparticles. Biokinetic behaviors can be dependent on physicochemical properties, dissolution property in biological fluids, and nanoparticle–protein interaction. Moreover, the determination of biological fates of ZnO nanoparticles in the systemic circulation and tissues is critical in interpreting biokinetic behaviors and predicting toxicity potential as well as mechanism. This review focuses on physicochemical factors affecting the biokinetics of ZnO nanoparticles, in concert with understanding bioavailable fates and their interaction with proteins. Keywords: ZnO nanoparticles, biokinetics, distribution, excretion, fate, interaction

Oxidative stress-mediated antibacterial activity of graphene oxide and reduced graphene oxide in Pseudomonas aeruginosa

OpenAIRE

Gurunathan, Sangiliyandi; Han,Jae Woong; Abdal Daye,Ahmed; Eppakayala,Vasuki; Kim,Jin-Hoi

2012-01-01

Sangiliyandi Gurunathan, Jae Woong Han, Ahmed Abdal Dayem, Vasuki Eppakayala, Jin-Hoi KimDepartment of Animal Biotechnology, Konkuk University, Seoul, South KoreaBackground: Graphene holds great promise for potential use in next-generation electronic and photonic devices due to its unique high carrier mobility, good optical transparency, large surface area, and biocompatibility. The aim of this study was to investigate the antibacterial effects of graphene oxide (GO) and reduced graphene oxid...

BANGUNAN TINGGI MULTI FUNGSI SEBAGAI SINTESIS ARSITEKTUR DAN STRUKTUR Studi Analisis Jin Mao Tower Grand Hyatt Shanghai

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Jimmy Priatman

2005-01-01

Full Text Available More than two decades, after the emerging of post- modern architecture, the split between construction technology and cultural expression in architecture appeared to become wider and wider. With the exception of a few "high-tech" buildings, the unity of art and applied science (technology in design seems facing challenges. It is interesting to see how fast and unexpectedly the situation has changed. Many factors and people played a role in this reversal, many new buildings demonstrate that utilitarian artifacts do not have to be oppressive to creativity but can evoke new innovation. One of the most significant contributors was JIN MAO TOWER at Shanghai, China. The paper analyses this building as a genuine synthesis of rational intelligence with art poetry that is still possible. Abstract in Bahasa Indonesia : Lebih dari dua dekade setelah timbulnya arsitektur pasca modern, pemisahan antara tekknologi konstruksi dan ekspresi kultural dalam arsitektur menjadi semakin lebar. Dengan perkecualian beberapa gedung "high-tech", kesatuan antara seni dan teknologi dalam tahap desain terlihat menghadapi tantangan tantangan. Tetapi menarik untuk diamati bahwa situasi telah berubah. Banyak faktor dan tokoh tokoh arsitek memegang peranan penting dalam perubahan ini, banyak bangunan bangunan baru mendemontrasikan bahwa artefak fungsionil tidak bearti menindas kreativitas namun dapat membangkitkan inovasi baru. Salah satu kontributor yang sangat penting adalah JIN MAO TOWER di Shanghai-China. Makalah ini membahas bangunan tersebut sebagai sintesis orijinal yang masih memungkinkan antara kecerdasan rasional dengan puisi seni arsitektur. Kata kunci: Sintesis.

Non-integrability of the Armbruster-Guckenheimer-Kim quartic Hamiltonian through Morales-Ramis theory

OpenAIRE

Acosta-Humánez, P.; Alvarez-Ramírez, M.; Stuchi, T.

2017-01-01

We show the non-integrability of the three-parameter Armburster-Guckenheimer-Kim quartic Hamiltonian using Morales-Ramis theory, with the exception of the three already known integrable cases. We use Poincar\\'e sections to illustrate the breakdown of regular motion for some parameter values.

Validation Study of Kim's Sham Needle by Measuring Facial Temperature: An N-of-1 Randomized Double-Blind Placebo-Controlled Clinical Trial

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Sanghun Lee

2012-01-01

Full Text Available Introduction. In 2008, Kim's sham needle was developed to improve the quality of double-blinded studies. The aim of this study is to validate Kim's sham needle by measuring facial temperature. Methods. We designed “N-of-1” trials involving 7 smokers. One session was composed of 2 stimulations separated by a 2 h washout period. Six sessions were applied daily for all subjects. Infrared thermal imaging was used to examine the effects of acupuncture (HT8, KI2 on facial temperature following smoking-induced decrease. Results. All subjects demonstrated decreased temperatures after sham needle treatment, but 5 of the 7 subjects showed increased temperatures after real needle treatment. 6 of the 7 subjects showed a significant difference (P<0.05 between treatments with real and sham needles. Thus, the physiological stimulation of Kim's sham needle is different from that of a real needle, suggesting that Kim's sham needle is a potential inactive control intervention.

Comorbidities in obstructive lung disease in Korea: data from the fourth and fifth Korean National Health and Nutrition Examination Survey

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Park HJ

2015-08-01

Full Text Available Hee Jin Park, Ah Young Leem, Sang Hoon Lee, Ju Han Song, Moo Suk Park, Young Sam Kim, Se Kyu Kim, Joon Chang, Kyung Soo Chung Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Severance Hospital, Institute of Chest Disease, Yonsei University College of Medicine, Seoul, South Korea Background: Comorbidities can occur frequently in patients with chronic obstructive pulmonary disease (COPD and can influence mortality and morbidity independently. It is increasingly recognized that many patients with COPD have comorbidities that have a major impact on their quality of life and survival. Therefore, we investigated the prevalence of comorbidities in Korean COPD populations. Methods: We used data obtained in the 6 years of the fourth and fifth Korean National Health and Nutrition Examination Survey (KNHANES IV and V. Among 50,405 subjects, 16,151 subjects aged ≥40 years who performed spirometry adequately were included in this study. Airway obstruction was defined as forced expiratory volume in 1 second/forced vital capacity <0.7, and the Global Initiative For Chronic Obstructive Lung Disease stage was used to evaluate the severity of airway obstruction. Statistical analyses were performed using SAS 9.2. Results: Among the 16,151 subjects (43.2% male, 56.8% female; mean age: 57.1 years for men and 57.2 years for women, 13.1% had obstructive lung function; 11.3%, restrictive lung function; and 75.6%, normal lung function. Among individuals with obstructive lung function, 45.3%, 49.4%, and 5.3% had mild, moderate, and severe and very severe airflow limitation. The prevalence of hypertension, diabetes mellitus (DM, underweight, and hypertriglyceridemia was higher in the obstructive lung function group than in the normal lung function group (49.6% vs 35.2%; 16.8% vs 10.5%; 3.3% vs 1.3%; 19.7% vs 17.0%. According to the severity of airway obstruction, hypertension and underweight were more common as severity increased

Silica nanoparticle-based dual imaging colloidal hybrids: cancer cell imaging and biodistribution

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Lee H

2015-08-01

Full Text Available Haisung Lee,1 Dongkyung Sung,2 Jinhoon Kim,3 Byung-Tae Kim,3 Tuntun Wang,4 Seong Soo A An,5 Soo-Won Seo,6 Dong Kee Yi4 1Molecular Diagnostics, In Vitro Diagnostics Unit, New Business Division, SK Telecom, 2Department of Life Sciences, Graduate School of Korea University, 3Interdisciplinary Graduate Program of Biomedical Engineering, School of Medicine, Sungkyunkwan University, Samsung Medical Center, 4Department of Chemistry, Myongji University, Seoul, 5Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, 6Medical Device Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu, Republic of Korea Abstract: In this study, fluorescent dye-conjugated magnetic resonance (MR imaging agents were investigated in T mode. Gadolinium-conjugated silica nanoparticles were successfully synthesized for both MR imaging and fluorescence diagnostics. Polyamine and polycarboxyl functional groups were modified chemically on the surface of the silica nanoparticles for efficient conjugation of gadolinium ions. The derived gadolinium-conjugated silica nanoparticles were investigated by zeta potential analysis, transmission electron microscopy, inductively coupled plasma mass spectrometry, and energy dispersive x-ray spectroscopy. MR equipment was used to investigate their use as contrast-enhancing agents in T1 mode under a 9.4 T magnetic field. In addition, we tracked the distribution of the gadolinium-conjugated nanoparticles in both lung cancer cells and organs in mice. Keywords: dual bioimaging, MR imaging, silica colloid, T1 contrast imaging, nanohybrid

SDE and SPME Analysis of Flavor Compounds in Jin Xuan Oolong Tea.

Science.gov (United States)

Sheibani, Ershad; Duncan, Susan E; Kuhn, David D; Dietrich, Andrea M; O'Keefe, Sean F

2016-02-01

Simultaneous distillation-extraction (SDE) and solid phase micro extraction (SPME) are procedures used for the isolation of flavor compounds in foods. The purpose of this study was to optimize SDE conditions (solvent and time) and to compare SDE with SPME for the isolation of flavor compounds in Jin Xuan oolong tea using GC-MS and GC-O. The concentration of volatile compounds isolated with diethyl ether was higher (P < 0.05) than for dichloromethane and concentration was higher at 40 min (P < 0.05) than 20 or 60 min extractions. For SDE, 128 volatiles were identified using GC-MS and 45 aroma active compounds using GC-O. Trans-nerolidol was the most abundant compound in oolong tea. The number of volatiles identified using GC-MS was lower in SPME than SDE. For SPME, 59 volatiles and 41 aroma active compounds were identified. The composition of the volatiles isolated by the 2 methods differed considerably but provided complementary information. © 2016 Institute of Food Technologists®

Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus.

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In O Sun

Full Text Available The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL and kidney injury molecule-1 (KIM-1 for acute kidney injury (AKI in patients with scrub typhus.From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI.Of the 138 patients, 25 had scrub typhus-associated AKI. The incidence of AKI was 18.1%; of which 11.6%, 4.3%, and 2.2% were classified as risk, injury, and failure, respectively, according to RIFLE criteria. Compared with patients in the non-AKI group, patients in the AKI group were older and showed higher total leukocyte counts and hypoalbuminemia or one or more comorbidities such as hypertension (72% vs 33%, p<0.01, diabetes (40% vs 14%, p<0.01, or chronic kidney disease (32% vs 1%, p<0.01. In addition, serum NGAL values (404± 269 vs 116± 78 ng/mL, P<0.001, KIM-1 values (0.80± 0.52 vs 0.33± 0.68 ng/mL, P<0.001, urine NGAL/creatinine values (371± 672 vs 27± 39 ng/mg, P<0.001 and urine KIM-1/creatinine values (4.04± 2.43 vs 2.38± 1.89 ng/mg, P<0.001 were higher in the AKI group than in the non-AKI group. By multivariate logistic regression, serum NGAL and the presence of chronic kidney disease were significant predictors of AKI.Serum NGAL might be an additive predictor for scrub typhus-associated AKI.

Association of blood eosinophils and plasma periostin with FEV1 response after 3-month inhaled corticosteroid and long-acting beta2-agonist treatment in stable COPD patients

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Park HY

2015-12-01

Full Text Available Hye Yun Park,1 Hyun Lee,1 Won-Jung Koh,1 Seonwoo Kim,2 Ina Jeong,3 Hyeon-Kyoung Koo,4 Tae-Hyung Kim,5 Jin Woo Kim,6 Woo Jin Kim,7 Yeon-Mok Oh,8 Don D Sin,9 Seong Yong Lim,10,* Sang-Do Lee8,* On behalf of the KOLD Study Group 1Division of Pulmonary and Critical Care Medicine, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea; 2Biostatistics Team, Samsung Biomedical Research Institute, Seoul, Korea; 3Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, National Medical Center, Seoul, Korea; 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Ilsan Paik Hospital, Inje University College of Medicine, Goyang, Korea; 5Division of Pulmonary and Critical Care Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Gyeonggi-do, Korea; 6Division of Pulmonology, Department of Internal Medicine, Uijeongbu St Mary’s Hospital, Gyunggi-do, Korea; 7Department of Internal Medicine, Kangwon National University, Chuncheon-si, Gangwon-do, Korea; 8Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; 9Respiratory Division, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; 10Division of Pulmonary and Critical Care Medicine, Department of Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea *These authors contributed equally to this work Background: COPD patients with increased airway eosinophilic inflammation show a favorable response to inhaled corticosteroids (ICS in combination with a long-acting bronchodilator. Recent studies have demonstrated a significant correlation of sputum eosinophilia with blood eosinophils and periostin. We investigated whether high blood eosinophils and plasma periostin were associated

Exposure–response model for sibutramine and placebo: suggestion for application to long-term weight-control drug development

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Han S

2015-09-01

Full Text Available Seunghoon Han,1,2 Sangil Jeon,1,2 Taegon Hong,1,2 Jongtae Lee,1,2 Soo Hyeon Bae,1,2 Wan-su Park,1,2 Gab-jin Park,1,2 Sunil Youn,1,2 Doo Yeon Jang,1,2 Kyung-Soo Kim,3 Dong-Seok Yim1,2 1Department of Pharmacology, College of Medicine, The Catholic University of Korea, 2Pharmacometrics Institute for Practical Education and Training, 3Department of Family Medicine, Seoul St Mary’s Hospital, Seochogu, Seoul, Republic of KoreaAbstract: No wholly successful weight-control drugs have been developed to date, despite the tremendous demand. We present an exposure–response model of sibutramine mesylate that can be applied during clinical development of other weight-control drugs. Additionally, we provide a model-based evaluation of sibutramine efficacy. Data from a double-blind, randomized, placebo-controlled, multicenter study were used (N=120. Subjects in the treatment arm were initially given 8.37 mg sibutramine base daily, and those who lost <2 kg after 4 weeks’ treatment were escalated to 12.55 mg. The duration of treatment was 24 weeks. Drug concentration and body weight were measured predose and at 4 weeks, 8 weeks, and 24 weeks after treatment initiation. Exposure and response to sibutramine, including the placebo effect, were modeled using NONMEM 7.2. An asymptotic model approaching the final body weight was chosen to describe the time course of weight loss. Extent of weight loss was described successfully using a sigmoidal exposure–response relationship of the drug with a constant placebo effect in each individual. The placebo effect was influenced by subjects’ sex and baseline body mass index. Maximal weight loss was predicted to occur around 1 year after treatment initiation. The difference in mean weight loss between the sibutramine (daily 12.55 mg and placebo groups was predicted to be 4.5% in a simulation of 1 year of treatment, with considerable overlap of prediction intervals. Our exposure–response model, which

Social influence of a religious hero: the late Cardinal Stephen Kim Sou-hwan's effect on cornea donation and volunteerism.

Science.gov (United States)

Bae, Hyuhn-Suhck; Brown, William J; Kang, Seok

2011-01-01

This study examined the mediated influence of a celebrated religious hero in South Korea, Cardinal Stephen Kim, through two forms of involvement--parasocial interaction and identification--on intention toward cornea donation and volunteerism, and it investigated how the news media diffused of his death. A structural equation modeling analysis with a Web-based voluntary survey of more than 1,200 people in South Korea revealed a multistep social influence process, beginning with parasocial interaction with Cardinal Kim, leading to identification with him, which predicted intention toward cornea donation and volunteerism. Additional investigations found that news of Cardinal Kim's death diffused rapidly through media and interpersonal communication. Results of this study demonstrate that religious leaders who achieve a celebrity hero status can prompt public discussion of important issues rather quickly through extensive media coverage, enabling them to promote prosocial behavior and positively affect public health.

Global Policing and the Case of Kim Dotcom

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Darren Palmer

2013-11-01

Full Text Available In early 2012, 76 heavily armed police conducted a raid on a house in Auckland, New Zealand. The targets were Kim Dotcom, a German national with a NZ residency visa, and several colleagues affiliated with Megaupload, an online subscription-based peer-to-peer (P2P file sharing facility. The alleged offences involved facilitating unlawful file sharing and United States federal criminal copyright violations. Following the raid, several court cases provide valuable insights into emerging ‘global policing’ practices (Bowling and Sheptycki 2012 based on communications between sovereign enforcement agencies.  This article uses these cases to explore the growth of ‘extraterritorial’ police powers that operate ‘across borders’ (Nadelmann 1993 as part of several broader transformations of global policing in the digital age.

CXCL14 Blockade of CXCL12/CXCR4 Signaling in Prostate Cancer Bone Metastasis

Science.gov (United States)

2017-10-01

10.1158/0008-5472.CAN-04-3785. 55. Jung Y, Kim JK, Shiozawa Y, Wang J, Mishra A, Joseph J, Berry JE, McGee S, Lee E, Sun H, Wang J, Jin T, Zhang H...and unfortunate complication of advanced prostate cancer resulting in significant pain and fractures . The most devastating consequence, however, is...treatments. These data suggest a mechanism of increased migration and invasion may be associated with expression of EMT genes. Regulation of Kinase

North Korea after Kim Chong-il: Leadership Dynamics and Potential Crisis Scenarios

Science.gov (United States)

2011-11-01

legal responsibility, and with specified procedures , the actual process is different.3 To date, regime dynamics in the Kim Chong-il era have been... procedures and regulations provide the outlines of formal rule, the 3 For a detailed examination of how...was also made an alternate member. It is also worth noting that 10 of the 12 members of the NDC were represented in the new Politburo lineup , thus

Enhanced oral bioavailability of valsartan using a polymer-based supersaturable self-microemulsifying drug delivery system

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Yeom DW

2017-05-01

Full Text Available Dong Woo Yeom,1,* Bo Ram Chae,2,* Ho Yong Son,1 Jin Han Kim,1 Jun Soo Chae,1 Seh Hyon Song,2 Dongho Oh,2 Young Wook Choi1 1College of Pharmacy, Chung-Ang University, Seoul, 2Daewon Pharm. Co., Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A novel, supersaturable self-microemulsifying drug delivery system (S-SMEDDS was successfully formulated to enhance the dissolution and oral absorption of valsartan (VST, a poorly water-soluble drug, while reducing the total quantity for administration. Poloxamer 407 is a selectable, supersaturating agent for VST-containing SMEDDS composed of 10% Capmul® MCM, 45% Tween® 20, and 45% Transcutol® P. The amounts of SMEDDS and Poloxamer 407 were chosen as formulation variables for a 3-level factorial design. Further optimization was established by weighting different levels of importance on response variables for dissolution and total quantity, resulting in an optimal S-SMEDDS in large quantity (S-SMEDDS_LQ; 352 mg in total and S-SMEDDS in reduced quantity (S-SMEDDS_RQ; 144.6 mg in total. Good agreement was observed between predicted and experimental values for response variables. Consequently, compared with VST powder or suspension and SMEDDS, both S-SMEDDS_LQ and S-SMEDDS_RQ showed excellent in vitro dissolution and in vivo oral bioavailability in rats. The magnitude of dissolution and absorption-enhancing capacities using quantity-based comparisons was in the order S-SMEDDS_RQ > S-SMEDDS_LQ > SMEDDS > VST powder or suspension. Thus, we concluded that, in terms of developing an effective SMEDDS preparation with minimal total quantity, S-SMEDDS_RQ is a promising candidate. Keywords: valsartan, SMEDDS, supersaturation, factorial design, optimization, bio­availability 

Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography.

Science.gov (United States)

Torregrosa, Isidro; Montoliu, Carmina; Urios, Amparo; Andrés-Costa, María Jesús; Giménez-Garzó, Carla; Juan, Isabel; Puchades, María Jesús; Blasco, María Luisa; Carratalá, Arturo; Sanjuán, Rafael; Miguel, Alfonso

2015-11-01

Acute kidney injury (AKI) is a common complication after coronary angiography. Early biomarkers of this disease are needed since increase in serum creatinine levels is a late marker. To assess the usefulness of urinary kidney injury molecule-1 (uKIM-1), neutrophil gelatinase-associated lipocalin (uNGAL) and liver-type fatty acid-binding protein (uL-FABP) for early detection of AKI in these patients, comparing their performance with another group of cardiac surgery patients. Biomarkers were measured in 193 patients, 12 h after intervention. In the ROC analysis, AUC for KIM-1, NGAL and L-FABP was 0.713, 0.958 and 0.642, respectively, in the coronary angiography group, and 0.716, 0.916 and 0.743 in the cardiac surgery group. Urinary KIM-1 12 h after intervention is predictive of AKI in adult patients undergoing coronary angiography, but NGAL shows higher sensitivity and specificity. L-FABP provides inferior discrimination for AKI than KIM-1 or NGAL in contrast to its performance after cardiac surgery. This is the first study showing the predictive capacity of KIM-1 for AKI after coronary angiography. Further studies are still needed to answer relevant questions about the clinical utility of biomarkers for AKI in different clinical settings.

1029: Tranexamic Acid for Pediatric Trauma

Science.gov (United States)

2014-12-01

parts. Of total 74 cases of rib fracture , the number of fracture between bone scan and CT are identical in only 9 cases (12%), and different in 65...OF BONE SCANNING IN THE DIAGNOSIS OF HIDDEN FRACTURE IN MAJOR TRAUMA PATIENTS Hang Joo Cho1, Sung Jeep Kim1, Jin Seok Baek2; 1The Catholic University...the hidden fracture . We investi- gated the usefulness of bone scan in the diagnosis of hidden fracture of major trauma patients. Methods: This study

Diglossie et biculturalisme littéraires :le cas de A Free Life, de Ha Jin

OpenAIRE

Perrin, Isabelle

2013-01-01

Le roman La Liberté de vivre, de Ha Jin, place son lecteur face à un type d’« écriture-traduction », puisqu’il suit le parcours d’un Chinois contraint par son exil aux États-Unis après les événements de Tian’anmen d’adopter la langue et la culture américaines. La représentation mimétique du réel joue sur le concept d’étrangeté, que le texte fait fonctionner en miroir : étrangeté des référents langagiers et culturels américains pour le héros chinois, étrangeté des référents langagiers et cultu...

Sexualidad violenta en el cine de Kim Ki-duk

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Daniel Muñoz Ruiz

2011-07-01

Full Text Available En sus más de 110 años de vida el cine ha representado la sexualidad humana en todas sus modalidades y desde los más variados puntos de vista. El cine de Kim Ki-duk ha sorprendido y escandalizado al público por su crudeza y, a veces, excesiva violencia. El director surcoreano ha explorado a lo largo de su filmografía el tema del sexo siempre desde puntos de vista dramáticos y hasta truculentos. En sus películas la mayoría de las relaciones sexuales carecen de amor y afecto. Nunca son placenteras. La violación, la prostitución, la violencia de género y las frustraciones sexuales son temas recurrentes en su cine.

Orthotopic liver transplantation after the combined use of locoregional therapy and sorafenib for advanced hepatocellular carcinoma

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Yoo EJ

2013-06-01

Full Text Available Eun Jin Yoo,1,* Hye Sun Shin,1,* Seung Up Kim,1,2,7 Dong Jin Joo,3,4 Jun Yong Park,1,2,7 Gi Hong Choi,3 Do Young Kim,1,2,7 Sang Hoon Ahn,1,2,7 Jinsil Seong,5 Myung Joo Koh,6 Kwang-Hyub Han,1,2,7 Chae Yoon Chon1,2,7 1Department of Internal Medicine, 2Institute of Gastroenterology, 3Department of Surgery, 4Research Institute for Transplantation, 5Department of Radiation Oncology, 6Department of Pathology, Yonsei University College of Medicine, Seoul, South Korea; 7Liver Cirrhosis Clinical Research Center, Seoul, South Korea *These authors contributed equally to this work Abstract: We herein report a patient with advanced hepatitis B virus-related hepatocellular carcinoma (HCC beyond the Milan criteria. He underwent orthotopic liver transplantation after successful HCC downstaging that satisfied the University of California, San Francisco criteria, using concurrent chemoradiation therapy with a combination of repeated hepatic arterial infusion chemotherapy (HAIC and sorafenib. A 52-year-old male was diagnosed with advanced hepatitis B virus-related HCC beyond the Milan criteria. He underwent concurrent chemoradiation therapy (50 Gy with 20 fractions over 5 weeks with HAIC using 5-fluorouracil at a dose of 500 mg/day, which was administered during the first and fifth weeks of radiation therapy as an initial treatment modality. This was followed by the combined use of HAIC using 5-fluorouracil (500 mg/m2 for 5 hours on days 1–3 and cisplatin (60 mg/m2 for 2 hours on day 2 every 4 weeks (twelve cycles and sorafenib (from the third to the twelfth cycle of HAIC to treat the remaining HCC. Because a remarkable decrease in the tumor burden that satisfied the University of California, San Francisco criteria was observed after these combination treatments, the patient underwent orthotopic liver transplantation with curative aim and survived for 11 months without evidence of HCC recurrence. Keywords: hepatocellular carcinoma, liver transplantation

Comparative steady-state pharmacokinetic study of an extended-release formulation of itopride and its immediate-release reference formulation in healthy volunteers

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Yoon, Seonghae; Lee, Howard; Kim, Tae-Eun; Lee, SeungHwan; Chee, Dong-Hyun; Cho, Joo-Youn; Yu, Kyung-Sang; Jang, In-Jin

2014-01-01

Seonghae Yoon,1,* Howard Lee,2,* Tae-Eun Kim,1 SeungHwan Lee,1 Dong-Hyun Chee,3 Joo-Youn Cho,1 Kyung-Sang Yu,1 In-Jin Jang1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, 2Clinical Trials Center, Seoul National University Hospital, 3AbbVie Ltd., Seoul, Republic of Korea *These authors contributed equally to this work Background: This study was conducted to compare the oral bioavailability of an itopride extended-release (ER...

Latent class analysis on internet and smartphone addiction in college students

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Mok, Jung-Yeon; Choi, Sam-Wook; Kim, Dai-Jin; Choi, Jung-Seok; Lee, Jaewon; Ahn, Heejune; Choi, Eun-Jeung; Song, Won-Young

2014-01-01

Jung-Yeon Mok,1 Sam-Wook Choi,1,2 Dai-Jin Kim,3 Jung-Seok Choi,4 Jaewon Lee,2 Heejune Ahn,5 Eun-Jeung Choi,6 Won-Young Song7 1Eulji Addiction Institute, Eulji University, Seoul, South Korea; 2Department of Psychiatry, Gangnam Eulji Hospital, Eulji University, Seoul, South Korea; 3Department of Psychiatry, Seoul St Mary's Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea; 4Department of Psychiatry, SMG-SNU Boramae Medical Center, Seoul, South Korea; 5Depar...

Targeting Biological Sensing with Commercial SERS Substrates

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2012-09-01

substrate substrate. Sl x 4 mm waf urement to re ossible contam substrates, fiv resented as an e being used f tigated, and nam eived in an ac cations...targeted nanotechnology-based inhalation co-delivery of anticancer drugs and siRNA," Journal of Drug Targeting, 900-914 (2011). [35] Jong , H.J., Na...J.H., Jin, B.S., Lee, W.K., Lee, W.H., Jung, H.J., Kim , S.C., Lim, S.H., Yu, Y.G., "Identification of Dinitrotoluene Selective Peptides by Phage

Social Support and Acculturative Stress among Korean International Students

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Ra, Young-An

2016-01-01

Previous studies have reported that international students in the US experience unique difficulties and acculturative stress related to cultural differences, language barriers, academic pressure, and interpersonal relationships (Mallinckrodt & Leong, 1992). Berry, Kim, Minde, and Mok (1987) defined this "acculturative stress" as…

The cost-effectiveness analysis of JinQi Jiangtang tablets for the treatment on prediabetes: a randomized, double-blind, placebo-controlled, multicenter design.

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Sun, Xiao; Guo, Liping; Shang, Hongcai; Ren, Ming; Wang, Yue; Huo, Da; Lei, Xiang; Wang, Hui; Zhai, Jingbo

2015-11-03

At present, diabetes is a chronic disease of great cost and heavy burdens. The International Diabetes Federation has repeatedly warned that by 2025, the global number of diabetics would rise to 333 million from 194 million in 2003. Although the occurrence of diabetes in developing countries is lower, China has a large population, so that the number of cases is increased. At the same time, more people have prediabetes, a growing health concern where a large percentage of the patients develop full type 2 diabetes. In addition, the patients of diabetes easily incur complications such as blindness, kidney failure, and cardiovascular diseases that can seriously affect the patients' quality of life and cause great economic burdens to family and society. Therefore, effective interventions for prediabetes are needed to prevent or delay the occurrence and development of diabetes. A randomized controlled trial that was assessed with pharmacoeconomic methods was undertaken in this study. The study term was 24 months (12 months for the intervention and 12 months for follow up). Four hundred participants, recruited from four cities in China: Beijing, Tianjin, Xian, and Naning, were randomized to the treatment group (JQJT tablets) and the control group (placebo). Participants included in this study had been diagnosed with prediabetes according to the criteria for western medicine and Traditional Chinese Medicine (TCM). The end-point effectiveness indexes included the incidence of diabetes and the reversion rate. The drug costs and lifestyle intervention costs were included in the total costs. The study used the cost-effectiveness analysis to discuss the economic advantage of the JQJT tablets. The outcomes of the study contained 2 sections,namely clinical outcomes and cost-effectiveness analysis outcomes. The clinical outcomes: the treatment group and control group had no significant statistical difference P> 0.05) on the baseline of situation; Jinqi Jiangtang tablet effectively

Clinical significance of NGAL and KIM-1 for acute kidney injury in patients with scrub typhus.

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Sun, In O; Shin, Sung Hye; Cho, A Young; Yoon, Hyun Ju; Chang, Mi Yok; Lee, Kwang Young

2017-01-01

The aim of this study is to investigate the clinical significance of neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) for acute kidney injury (AKI) in patients with scrub typhus. From 2014 to 2015, 145 patients were diagnosed with scrub typhus. Of these, we enrolled 138 patients who were followed up until renal recovery or for at least 3 months. We measured serum and urine NGAL and KIM-1 levels and evaluated prognostic factors affecting scrub typhus-associated AKI. Of the 138 patients, 25 had scrub typhus-associated AKI. The incidence of AKI was 18.1%; of which 11.6%, 4.3%, and 2.2% were classified as risk, injury, and failure, respectively, according to RIFLE criteria. Compared with patients in the non-AKI group, patients in the AKI group were older and showed higher total leukocyte counts and hypoalbuminemia or one or more comorbidities such as hypertension (72% vs 33%, pscrub typhus-associated AKI.

A Misleading Review of Response Bias: Comment on McGrath, Mitchell, Kim, and Hough (2010)

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Rohling, Martin L.; Larrabee, Glenn J.; Greiffenstein, Manfred F.; Ben-Porath, Yossef S.; Lees-Haley, Paul; Green, Paul; Greve, Kevin W.

2011-01-01

In the May 2010 issue of "Psychological Bulletin," R. E. McGrath, M. Mitchell, B. H. Kim, and L. Hough published an article entitled "Evidence for Response Bias as a Source of Error Variance in Applied Assessment" (pp. 450-470). They argued that response bias indicators used in a variety of settings typically have insufficient data to support such…

Procjena citomorfologije, HPV statusa i HPV 16 genotipa u predikciji ishoda bolesti kod pacijentica s citološkim nalazom ASCUS i LSIL

OpenAIRE

Vrdoljak-Mozetič, Danijela; Štemberger-Papić, Snježana; Verša Ostojić, Damjana; Rubeša-Mihaljević, Roberta; Dinter, Morana; Brnčić-Fischer, Alemka; Krašević, Maja

2016-01-01

Cilj: Istražiti međusobnu povezanost i prognostički značaj HPV statusa (humani papiloma-virus), HPV 16 genotipa i citomorfologije kod pacijentica s citološkim nalazom abnormalnih stanica pločastog epitela vrata maternice graničnog i blagog stupnja. Materijali i metode: U studiju su uključene pacijentice s inicijalnim citološkim nalazom vrata maternice atipičnih skvamoznih stanica neodređenog značenja (ASCUS, N = 160) i skvamozne intraepitelne lezije niskog stupnja (LSIL, N = 155). Analizirane...

The fate of calcium carbonate nanoparticles administered by oral route: absorption and their interaction with biological matrices

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Lee JA

2015-03-01

Full Text Available Jeong-A Lee,1,* Mi-Kyung Kim,1,* Hyoung-Mi Kim,2,* Jong Kwon Lee,3 Jayoung Jeong,4 Young-Rok Kim,5 Jae-Min Oh,2 Soo-Jin Choi1 1Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea; 2Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Wonju, Republic of Korea; 3Hazard Substances Analysis Division, Gwangju Regional Food and Drug Administration, Ministry of Food and Drug Safety, Gwangju, Republic of Korea; 4Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Ministry of Food and Drug Safety, Chungcheongbuk-do, Republic of Korea; 5Department of Food Science and Biotechnology, Kyung Hee University, Yongin, Republic of Korea *These authors contributed equally to this work Background: Orally administered particles rapidly interact with biological fluids containing proteins, enzymes, electrolytes, and other biomolecules to eventually form particles covered by a corona, and this corona potentially affects particle uptake, fate, absorption, distribution, and elimination in vivo. This study explored relationships between the biological interactions of calcium carbonate particles and their biokinetics.Methods: We examined the effects of food grade calcium carbonates of different particle size (nano [N-Cal] and bulk [B-Cal]: specific surface areas of 15.8 and 0.83 m2/g, respectively on biological interactions in in vitro simulated physiological fluids, ex vivo biofluids, and in vivo in gastrointestinal fluid. Moreover, absorption and tissue distribution of calcium carbonates were evaluated following a single dose oral administration to rats.Results: N-Cal interacted more with biomatrices than bulk materials in vitro and ex vivo, as evidenced by high fluorescence quenching ratios, but it did not interact more actively with biomatrices in vivo. Analysis of coronas revealed that immunoglobulin, apolipoprotein, thrombin, and fibrinogen

Enhanced bioavailability of sirolimus via preparation of solid dispersion nanoparticles using a supercritical antisolvent process

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Kim MS

2011-11-01

Full Text Available Min-Soo Kim1, Jeong-Soo Kim1, Hee Jun Park1, Won Kyung Cho1,3, Kwang-Ho Cha1,3, Sung-Joo Hwang2,31College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea, 2College of Pharmacy, 3Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of KoreaBackground: The aim of this study was to improve the physicochemical properties and bioavailability of poorly water-soluble sirolimus via preparation of a solid dispersion of nanoparticles using a supercritical antisolvent (SAS process.Methods: First, excipients for enhancing the stability and solubility of sirolimus were screened. Second, using the SAS process, solid dispersions of sirolimus-polyvinylpyrrolidone (PVP K30 nanoparticles were prepared with or without surfactants such as sodium lauryl sulfate (SLS, tocopheryl propylene glycol succinate, Sucroester 15, Gelucire 50/13, and Myrj 52. A mean particle size of approximately 250 nm was obtained for PVP K30-sirolimus nanoparticles. Solid state characterization, kinetic solubility, powder dissolution, stability, and pharmacokinetics were analyzed in rats.Results: X-ray diffraction, differential scanning calorimetry, and high-pressure liquid chromatography indicated that sirolimus existed in an anhydrous amorphous form within a solid dispersion of nanoparticles and that no degradation occurred after SAS processing. The improved supersaturation and dissolution of sirolimus as a solid dispersion of nanoparticles appeared to be well correlated with enhanced bioavailability of oral sirolimus in rats. With oral administration of a solid dispersion of PVP K30-SLS-sirolimus nanoparticles, the peak concentration and AUC0→12h of sirolimus were increased by approximately 18.3-fold and 15.2-fold, respectively.Conclusion: The results of this study suggest that preparation of PVP K30-sirolimus-surfactant nanoparticles using the SAS process may be a promising approach for improving the bioavailability of sirolimus

Materialismo percettivo. Da Democrito a Lenin, da Hobbes a Kim

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Michele Gardini

2012-05-01

Full Text Available The paper tries to outline something like a short “critique of pure materialism” in the domain of perception, a sketch showing – through a series of examples, picked out in an apparently heterogeneous fashion from the Western philosophical tradition – how this epistemological model each time, and in everyone of its forms, fails in giving account of the basic features of perceiving.  After giving a survey of authors like Democritus, Hobbes, De Sade, Lenin, the final appendix, devoted to the concept of “supervenience” and its treatment in Davidson and Kim, aims at summarizing the whole problem through the categories of the contemporary philosophy of mind. The conclusion is that a pure materialistic approach is incapable to give reason to some of the fundamental characteristics of perception, that make it one of the basic moods of “being-in-the-world”.

"The Day All of the Different Parts of Me Can Come Along": Intersectionality and U.S. Third World Feminism in the Poetry of Pat Parker and Willyce Kim.

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Van Ausdall, Mimi Iimuro

2015-01-01

This article brings to light the poetry of Pat Parker and Willyce Kim, two key figures within the 1970s and '80s women in print movement. While Parker and Kim have been rightly placed within African-American and Asian-American histories, respectively, and working-class and lesbian-feminist literary histories, their work is most fully understood within the context of U.S. Third World Feminism. Through close readings of poetic form and content in addition to engagement with current debates about intersectionality as a methodology, the article links Kim and Parker's works to central contributions of U.S. Third World Feminism such as intersectionality and power across and within difference that continue to influence feminist theory today.

Muusikauudised : Lu : k ja Jäääär koos laval. Britney Spears tegutseb. Lenny Kravitz ja Mick Jagger. Kim Wilde

Index Scriptorium Estoniae

2001-01-01

Tartus Sõbra majas toimunud kontserdist. Videost "Britney: The video". Heliplaatidest: "Britney", "The Best of Pink Floyd", "Lenny", Mick Jagger "Goddess In The Doorway", "The Very Best Of Kim Wilde"

"Sundiata, Lion King of Mali." Adapted by Kim Hines, Featuring Griot Alhaji Papa Susso, Cue Sheet for Students.

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Freeman, Aakhu TuahNera

This performance guide is designed for teachers to use with students before and after a performance of "Sundiata: Lion King of Mali," adapted by Kim Hines and featuring Griot Alhaji Papa Susso. The guide, called a "Cuesheet," contains seven activity sheets for use in class, addressing: (1) Sundiata: Man & Myth (discusses…

Dynamic Changes Analysis and Hotspots Detection of Land Use in the Central Core Functional Area of Jing-Jin-Ji from 2000 to 2015 Based on Remote Sensing Data

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Yafei Li

2017-01-01

Full Text Available The article uses GIS spatial analysis and grid technologies to study the dynamic changes, hotspot regions, and driving forces in land use of the central core functional area of Jing-Jin-Ji. The research results are as follows: from 2000 to 2015, the main types of land use in the central core functional area of Jing-Jin-Ji are cultivated land, woodland, and built-up land. In the period of 2005–2010, the transfer between built-up land and cultivated land was frequent. The dynamic degree of single land use in unused land was highest. It also finds out that the dynamic degree of the integrated land use from 2005 to 2010 was higher. The center of gravity transfer of the dynamic degree of integrated land use was concentrated in research area. As for the hotspots, their number and scope are increasing, and the positions located in the edge of original main urban area and developed transportation network. The main characteristics of land use dynamic change in the study area are the rapid decrease of cultivated land area and rapid growth of built-up land. The spatial agglomeration of economic factors caused by human activities has an important influence on the spatial and temporal dynamic changes of land use.

A pharmacokinetic and pharmacodynamic drug interaction between rosuvastatin and valsartan in healthy subjects

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Jung JA

2015-03-01

Full Text Available Jin Ah Jung,1 Soo-Yun Lee,2 Jung-Ryul Kim,1 Jae-Wook Ko,1,2 Seong Bok Jang,3 Su Youn Nam,3 Wooseong Huh1,41Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, 2Department of Health Sciences and Technology, Samsung Advanced Institute for Health Sciences and Technology, Sungkyunkwan University, 3Yuhan Research Institute, Yuhan Corporation, 4Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaPurpose: Valsartan, an angiotensin-receptor blocker, and rosuvastatin, a competitive inhibitor of the 3-hydroxy-3-methylglutaryl coenzyme A reductase, are frequently coadministered to treat patients with hypertension and dyslipidemia. The study reported here sought to evaluate the pharmacokinetic and pharmacodynamic interactions between rosuvastatin and valsartan in healthy Korean subjects. Subjects and methods: Thirty healthy male Korean subjects were administered with rosuvastatin (20 mg/day, valsartan (160 mg/day, and both drugs concomitantly for 4 days in a randomized, open-label, multiple-dose, three-treatment, three-period crossover study. Plasma concentrations of rosuvastatin, N-desmethyl rosuvastatin, and valsartan were determined using validated high-performance liquid chromatography with tandem mass spectrometry. Lipid profiles and vital signs (systolic and diastolic blood pressure and pulse rate were measured for the pharmacodynamic assessment.Results: For rosuvastatin, the geometric mean ratios (90% confidence intervals [CIs] of coadministration to mono-administration were 0.8809 (0.7873-0.9857 for maximum plasma concentration at steady state and 0.9151 (0.8632-0.9701 for area under the concentration–time curve (AUC over a dosing interval at steady state. For valsartan, the geometric mean ratios (90% CIs of those were 0.9300 (0.7946-1.0884 and 1.0072 (0.8893-1.1406, respectively. There were no significant differences in the metabolic ratio of N

Differences in immunolocalization of Kim-1, RPA-1, and RPA-2 in kidneys of gentamicin-, cisplatin-, and valproic acid-treated rats: potential role of iNOS and nitrotyrosine.

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Zhang, Jun; Goering, Peter L; Espandiari, Parvaneh; Shaw, Martin; Bonventre, Joseph V; Vaidya, Vishal S; Brown, Ronald P; Keenan, Joe; Kilty, Cormac G; Sadrieh, Nakissa; Hanig, Joseph P

2009-08-01

The present study compared the immunolocalization of Kim-1, renal papillary antigen (RPA)-1, and RPA-2 with that of inducible nitric oxide synthase (iNOS) and nitrotyrosine in kidneys of gentamicin sulfate (Gen)- and cisplatin (Cis)-treated rats. The specificity of acute kidney injury (AKI) biomarkers, iNOS, and nitrotyrosine was evaluated by dosing rats with valproic acid (VPA). Sprague-Dawley (SD) rats were injected subcutaneously (sc) with 100 mg/kg/day of Gen for six or fourteen days; a single intraperitoneal (ip) dose of 1, 3, or 6 mg/kg of Cis; or 650 mg/kg/day of VPA (ip) for four days. In Gen-treated rats, Kim-1 was expressed in the epithelial cells, mainly in the S1/S2 segments but less so in the S3 segment, and RPA-1 was increased in the epithelial cells of collecting ducts (CD) in the cortex. Spatial expression of iNOS or nitrotyrosine with Kim-1 or RPA-1 was detected. In Cis-treated rats, Kim-1 was expressed only in the S3 segment cells, and RPA-1 and RPA-2 were increased in the epithelial cells of medullary CD or medullary loop of Henle (LH), respectively. Spatial expression of iNOS or nitrotyrosine with RPA-1 or RPA-2 was also identified. These findings suggest that peroxynitrite formation may be involved in the pathogenesis of Gen and Cis nephrotoxicity and that Kim-1, RPA-1, and RPA-2 have the potential to serve as site-specific biomarkers for Gen or Cis AKI.

Effects of amoxicillin/clavulanic acid on the pharmacokinetics of valproic acid

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Lee SY

2015-08-01

Full Text Available Soo-Yun Lee,1 Wooseong Huh,2 Jin Ah Jung,3 Hye Min Yoo,2 Jae-Wook Ko,1,2 Jung-Ryul Kim2,4 1Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University, 2Department of Clinical Pharmacology and Therapeutics, Samsung Medical Center, Seoul, 3Department of Clinical Pharmacology, Inje University, Busan Paik Hospital, Busan, 4Department of Clinical Research and Evaluation, SAIHST, Sungkyunkwan University, Seoul, Republic of Korea Abstract: Valproic acid (VPA is mainly metabolized via glucuronide, which is hydrolyzed by β-glucuronidase and undergoes enterohepatic circulation. Amoxicillin/clavulanic acid (AMC administration leads to decreased levels of β-glucuronidase-producing bacteria, suggesting that these antibiotics could interrupt enterohepatic circulation and thereby alter the pharmacokinetics of VPA. This study aimed to evaluate the effects of AMC on the pharmacokinetics of VPA. This was an open-label, two-treatment, one-sequence study in 16 healthy volunteers. Two treatments were evaluated; treatment VPA, in which a single dose of VPA 500 mg was administered, and treatment AMC + VPA, in which multiple doses of AMC 500/125 mg were administered three times daily for 7 days and then a single dose of VPA was administered. Blood samples were collected up to 48 hours. Pharmacokinetic parameters were calculated using noncompartmental methods. Fifteen subjects completed the study. Systemic exposures and peak concentrations of VPA were slightly lower with treatment AMC + VPA than with treatment VPA (AUClast, 851.0 h·mg/L vs 889.6 h·mg/L; Cmax, 52.1 mg/L vs 53.0 mg/L. There were no significant between-treatment effects on pharmacokinetics (95% confidence interval [CI] of AUClast and Cmax (95.7 [85.9–106.5] and 98.3 [91.6–105.6], respectively. Multiple doses of AMC had no significant effects on the pharmacokinetics of VPA; thus, no dose adjustment is necessary. Keywords: drug–drug interaction, pharmacokinetics

Transcriptional control of the isoeugenol monooxygenase of Pseudomonas nitroreducens Jin1 in Escherichia coli.

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Ryu, Ji-Young; Seo, Jiyoung; Ahn, Joong-Hoon; Sadowsky, Michael J; Hur, Hor-Gil

2012-01-01

Vanillin is one of the most valuable compounds in the flavoring and fragrance industries, and many attempts to produce natural vanillin have been made in recent years. Isoeugenol monooxygenase (Iem) converts the phenylpropanoid compound isoeugenol to vanillin. In Pseudomonas nitroreducens Jin1, the positive regulatory protein IemR is divergently expressed from Iem, and the promoter region is located between the genes. In this study, we investigated the transcriptional regulation of iem in Escherichia coli. We focused on inducers and regulatory protein IemR. Transcription of iem was found to be dependent on the amounts of isoeugenol and IemR. Isoeugenol was found to be the best inducer of iem, followed by trans-anethole, which induced iem to 58% of the transcription level observed for isoeugenol. Overproduction of IemR in E. coli significantly increased the transcription of iem, up to 96-fold, even in the absence of isoeugenol, as compared to basally expressed IemR. Results of this study indicate that the transcription of iem iss dependent on the type of inducers and on IemR. They should contribute to the development of bioengineering strategies for increased production of vanillin through high-level expression of the isoeugenol monooxygenase gene in microorganisms.

Predicting treatable traits for long-acting bronchodilators in patients with stable COPD

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Kang J

2017-12-01

Full Text Available Jieun Kang,1,* Ki Tae Kim,2,* Ji-Hyun Lee,3 Eun Kyung Kim,3 Tae-Hyung Kim,4 Kwang Ha Yoo,5 Jae Seung Lee,1 Woo Jin Kim,6 Ju Han Kim,2 Yeon-Mok Oh1 1Department of Pulmonology and Critical Care Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, 2Seoul National University Biomedical Informatics and Systems Biomedical Informatics Research Center, Division of Biomedical Informatics, Seoul National University College of Medicine, Seoul, 3Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, 4Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, 5Department of Internal Medicine, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, 6Department of Internal Medicine and Environmental Health Center, Kangwon National University Hospital, School of Medicine, Kangwon National University, Chuncheon, South Korea *These authors contributed equally to this work Purpose: There is currently no measure to predict a treatability of long-acting β-2 agonist (LABA or long-acting muscarinic antagonist (LAMA in patients with chronic obstructive pulmonary disease (COPD. We aimed to build prediction models for the treatment response to these bronchodilators, in order to determine the most responsive medication for patients with COPD.Methods: We performed a prospective open-label crossover study, in which each long-acting bronchodilator was given in a random order to 65 patients with stable COPD for 4 weeks, with a 4-week washout period in between. We analyzed 14 baseline clinical traits, expression profiles of 31,426 gene transcripts, and damaged-gene scores of 6,464 genes acquired from leukocytes. The gene expression profiles were measured by RNA microarray and the damaged-gene scores were obtained after DNA exome sequencing. Linear regression analyses were performed to build prediction models after using

Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka

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Mohammed Abdul, Khaja Shameem; Eakanayake, Eakanayake M. D. V.; Jayasinghe, Sudheera Sammanthi; Jayasumana, Channa; Asanthi, Hewa Bandulage; Perera, Hettiarachigae S. D.; Chaminda, Gamage G. Tushara; Chandana, Ediriweera P. S.; Siribaddana, Sisira H.

2016-01-01

Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734) were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence) and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1) and Bandagiriya (EL2). Albuminuria (ACR ≥ 30mg/g); serum creatinine based estimation of glomerular filtration rate (eGFR); creatinine normalized urinary kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were measured. Fourteen new CKDu cases (18%) from EL1 and nine CKDu cases (9%) from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr). No CKDu cases were identified in non-endemic study locations in Matara (CM) and Nuwara Eliya (CN). Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal injury

Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu among Agricultural Communities in Sri Lanka.

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Pallagae Mangala C S De Silva

2016-09-01

Full Text Available Chronic Kidney Disease of uncertain etiology (CKDu is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734 were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1 and Bandagiriya (EL2. Albuminuria (ACR ≥ 30mg/g; serum creatinine based estimation of glomerular filtration rate (eGFR; creatinine normalized urinary kidney injury molecule (KIM-1 and neutrophil gelatinase-associated lipocalin (NGAL were measured. Fourteen new CKDu cases (18% from EL1 and nine CKDu cases (9% from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr. No CKDu cases were identified in non-endemic study locations in Matara (CM and Nuwara Eliya (CN. Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal

Urinary Biomarkers KIM-1 and NGAL for Detection of Chronic Kidney Disease of Uncertain Etiology (CKDu) among Agricultural Communities in Sri Lanka.

Science.gov (United States)

De Silva, Pallagae Mangala C S; Mohammed Abdul, Khaja Shameem; Eakanayake, Eakanayake M D V; Jayasinghe, Sudheera Sammanthi; Jayasumana, Channa; Asanthi, Hewa Bandulage; Perera, Hettiarachigae S D; Chaminda, Gamage G Tushara; Chandana, Ediriweera P S; Siribaddana, Sisira H

2016-09-01

Chronic Kidney Disease of uncertain etiology (CKDu) is an emerging epidemic among farming communities in rural Sri Lanka. Victims do not exhibit common causative factors, however, histopathological studies revealed that CKDu is a tubulointerstitial disease. Urine albumin or albumin-creatinine ratio is still being used as a traditional diagnostic tool to identify CKDu, but accuracy and prevalence data generated are questionable. Urinary biomarkers have been used in similar nephropathy and are widely recognised for their sensitivity, specificity and accuracy in determining CKDu and early renal injury. However, these biomarkers have never been used in diagnosing CKDu in Sri Lanka. Male farmers (n = 1734) were recruited from 4 regions in Sri Lanka i.e. Matara and Nuwara Eliya (farming locations with no CKDu prevalence) and two CKDu emerging locations from Hambantota District in Southern Sri Lanka; Angunakolapelessa (EL1) and Bandagiriya (EL2). Albuminuria (ACR ≥ 30mg/g); serum creatinine based estimation of glomerular filtration rate (eGFR); creatinine normalized urinary kidney injury molecule (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) were measured. Fourteen new CKDu cases (18%) from EL1 and nine CKDu cases (9%) from EL2 were recognized for the first time from EL1, EL2 locations, which were previously considered as non-endemic of the disease and associated with persistent albuminuria (ACR ≥ 30mg/g Cr). No CKDu cases were identified in non-endemic study locations in Matara (CM) and Nuwara Eliya (CN). Analysis of urinary biomarkers showed urinary KIM-1 and NGAL were significantly higher in new CKDu cases in EL1 and EL2. However, we also reported significantly higher KIM-1 and NGAL in apparently healthy farmers in EL 1 and EL 2 with comparison to both control groups. These observations may indicate possible early renal damage in absence of persistent albuminuria and potential capabilities of urinary KIM-1 and NGAL in early detection of renal injury

The Competitive status of the U.S. auto industry: a study of the influences of technology in determining international industrial competitive advantage

National Research Council Canada - National Science Library

Automobile Panel of the Committee on Technology; National Research Council Staff

... International Industrial Competitive Advantage Prepared by the Automobile Panel, Committee on Technology and International Economic and Trade Issues of the Office of the Foreign Secretary, National Academy of Engineering and the Commission on Engineering and Technical Systems, National Research Council William J. Abernathy, Chairman Kim Clar...

Fresh insights | IDRC - International Development Research Centre

International Development Research Centre (IDRC) Digital Library (Canada)

2011-07-08

Jul 8, 2011 ... ... the effectiveness of price subsidies in reducing the financial burden of health ... reimbursing in-patient costs (Feng Jin, Fudan University, Shanghai). ... Community solidarity helps to solve environmental and health problems.

Magnetic flux creep in HTSC and Anderson-Kim theory

International Nuclear Information System (INIS)

Lykov, A.N.

2014-01-01

The theoretical and experimental data on flux creep in high-temperature superconductors (HTSC) were analyzed in the review paper. On the one hand, the main attention is paid to the most striking experimental results which have had a significant influence on the investigations of flux creep in HTSC. On the other hand, the analysis of theoretical studies is concentrated on the works, which explain the features of flux creep on the basis of the Anderson-Kim (AK) theory modifications, and received previously unsufficient attention. However, it turned out that the modified AK theory could explain a lot of features of flux creep in HTSC: the scaling behaviour of current-voltage curves of HTSC, the finite rate of flux creep at ultra low temperatures, the logarithmic dependence of effective pinning potential as a function of transport current and its decrease with temperature. The harmonic potential field which is used in this approach makes it possible to solve accurately the both problems: viscous vortex motion and flux creep in this field. Moreover the distribution of pinning potential and the interaction of vortices with each other are taken into account in the approach. Thus, the modification of the AK theory consists, essentially, in its detailed elaboration and approaching to real situations in superconductors

Light Microscopy Module: International Space Station Premier Automated Microscope

Science.gov (United States)

Sicker, Ronald J.; Foster, William M.; Motil, Brian J.; Meyer, William V.; Chiaramonte, Francis P.; Abbott-Hearn, Amber; Atherton, Arthur; Beltram, Alexander; Bodzioney, Christopher; Brinkman, John;

Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time

NARCIS (Netherlands)

Kramer, Andrea B.; van Timmeren, Mirjan M.; Schuurs, Theo A.; Vaidya, Vishal S.; Bonventre, Joseph V.; van Goor, Harry; Navis, Gerjan

Kramer AB, van Timmeren MM, Schuurs TA, Vaidya VS, Bonventre JV, van Goor H, Navis G. Reduction of proteinuria in adriamycin-induced nephropathy is associated with reduction of renal kidney injury molecule (Kim-1) over time. Am J Physiol Renal Physiol 296: F1136-F1145, 2009. First published February

Space-time PM2.5 mapping in the severe haze region of Jing-Jin-Ji (China) using a synthetic approach.

Science.gov (United States)

He, Junyu; Christakos, George

2018-05-07

Long- and short-term exposure to PM 2.5 is of great concern in China due to its adverse population health effects. Characteristic of the severity of the situation in China is that in the Jing-Jin-Ji region considered in this work a total of 2725 excess deaths have been attributed to short-term PM 2.5 exposure during the period January 10-31, 2013. Technically, the processing of large space-time PM 2.5 datasets and the mapping of the space-time distribution of PM 2.5 concentrations often constitute high-cost projects. To address this situation, we propose a synthetic modeling framework based on the integration of (a) the Bayesian maximum entropy method that assimilates auxiliary information from land-use regression and artificial neural network (ANN) model outputs based on PM 2.5 monitoring, satellite remote sensing data, land use and geographical records, with (b) a space-time projection technique that transforms the PM 2.5 concentration values from the original spatiotemporal domain onto a spatial domain that moves along the direction of the PM 2.5 velocity spread. An interesting methodological feature of the synthetic approach is that its components (methods or models) are complementary, i.e., one component can compensate for the occasional limitations of another component. Insight is gained in terms of a PM 2.5 case study covering the severe haze Jing-Jin-Ji region during October 1-31, 2015. The proposed synthetic approach explicitly accounted for physical space-time dependencies of the PM 2.5 distribution. Moreover, the assimilation of auxiliary information and the dimensionality reduction achieved by the synthetic approach produced rather impressive results: It generated PM 2.5 concentration maps with low estimation uncertainty (even at counties and villages far away from the monitoring stations, whereas during the haze periods the uncertainty reduction was over 50% compared to standard PM 2.5 mapping techniques); and it also proved to be computationally very

Gu Jin Tan Gai with the Perspective of Carnival Poetics%狂欢诗学视域下的《古今谭概》

Institute of Scientific and Technical Information of China (English)

刘云春; 赵豫科

2014-01-01

《古今谭概》是晚明著名文学家冯梦龙编纂的一部笑话集。他在博览历代正史、稗官野史的基础上，选取众多可笑有趣的逸闻趣事，以戏谑的口吻略加评点，遂成此集。《古今谭概》内容多为真人真事，上自历代君主，下至市井百姓，各色人等，种种笑话，应有尽有。本文运用文艺理论家巴赫金的狂欢诗学理论，从时空狂欢、语言狂欢、体裁狂欢、狂欢的内核几个层面对其进行解读，论述了作品产生的时代背景和狂欢化艺术特色，旨在发掘文本内涵，拓宽文本研究视野，发现其更深层次的文学价值。%Gu Jin Tan Gai is a collection of jokes compiled by Feng Menglong. He selects many stories from the official history and the romance and comments in a bantering tone. A majority of the content is true which in-cludes emperors and common people. This paper uses the Russian literary theorist Bakhtin's Carnival Poetics theory to discuss four aspects:space - time carnival,language carnival,style carnival,carnival essence. The paper dis-cusses the background and carnival artistic characteristics of Gu Jin Tan Gai to find the deeper value of literature.

Study of provenance character on ancient celadon of Jin Dynasty produced in Yaozhou Kiln of Lidipo and Shangdian using nuclear technology

International Nuclear Information System (INIS)

Wang, Y.Q.; Feng, S.L.; Feng, X.Q.; Lei, Y.; Cheng, L.; Xu, Q.; Zhou, Z.X.; Xue, D.X.

2005-01-01

Yaozhou ware is a typical product of celadon porcelain in northern China. It was very famous for the various color glazes, multiple utensils and unique grain pattern. Yaozhou kiln series were made of Tongchuan, Lidipo, Shangdian, Chenlu kiln site and etc in Shanxi Province of china. It is one of seven kiln series in China. Celadon samples of 63 pieces of sherds were collected, which excavated in stratum of Jin Dynasty (1127-1234A.D.) from Yaozhou kiln of Lidipo and Shangdian sites. The main and trace elements of theses specimens were analyzed by NAA and EDXRF respectively. The contents of 10 main and 18 trace elements were determined precisely. The experimental data are performed with factor and discrimination analysis of statistic method. The result indicates that the trace elements can reveal the provenance character of porcelain better than main compositions.

Novel phytoceramides containing fatty acids of diverse chain lengths are better than a single C18-ceramide N-stearoyl phytosphingosine to improve the physiological properties of human stratum corneum

Directory of Open Access Journals (Sweden)

Oh MJ

2017-09-01

Full Text Available Myoung Jin Oh,1 Young Hoon Cho,1 So Yoon Cha,1 Eun Ok Lee,2 Jin Wook Kim,2 Sun Ki Kim,2 Chang Seo Park1 1Department of Chemical and Biochemical Engineering, Dongguk University, Chung-gu, Seoul, 2LCS Biotech, Gwonseon-gu, Suwon-si, Gyeonggi-do, Republic of Korea Abstract: Ceramides in the human stratum corneum (SC are a mixture of diverse N-acylated fatty acids (FAs with different chain lengths. C24 is the major class of FAs of ceramides. However, there are also other classes of ceramides with diverse chain lengths of FAs, and these lengths generally range from C16 to C26. This study aimed to prepare several types of phytoceramide containing diverse chain lengths of N-acylated FAs and compare them with C18-ceramide N-stearoyl phytosphingosine (NP in terms of their effects on the physiological properties of the SC. We chose natural oils, such as horse fat oil, shea butter, sunflower oil, and a mixture of macadamia nut, shea butter, moringa, and meadowfoam seed oil, as sources of FAs and phytosphingosine as a sphingoid backbone to synthesize diverse phytoceramides. Each phytoceramide exhibited a distinctive formation of the lamellar structure, and their FA profiles were similar to those of their respective natural oil. The skin barrier properties, as analyzed in human skin, clearly demonstrated that all the phytoceramides improved the recovery rate of the damaged SC and enhanced hydration better than C18-ceramide NP did. In conclusion, natural oil-derived phytoceramides could represent a novel class of ceramides for cosmetic applications in the development of an ideal skin barrier moisturizer. Keywords: fatty acid, chain length, phytoceramide, skin barrier, natural oil

Revealing Interactions between Human Resources, Quality of Life and Environmental Changes within Socially-oriented Observations : Results from the IPY PPS Arctic Project in the Russian North

Science.gov (United States)

Vlasova, Tatiana

2010-05-01

Socially-oriented Observations (SOO) in the Russian North have been carried out within multidisciplinary IPY PPS Arctic project under the leadership of Norway and supported by the Research Council of Norway as well as Russian Academy of Sciences. The main objective of SOO is to increase knowledge and observation of changes in quality of life conditions (state of natural environment including climate and biota, safe drinking water and foods, well-being, employment, social relations, access to health care and high quality education, etc.) and - to reveal trends in human capital and capacities (health, demography, education, creativity, spiritual-cultural characteristics and diversity, participation in decision making, etc.). SOO have been carried out in industrial cities as well as sparsely populated rural and nature protection areas in observation sites situated in different bioms (from coastal tundra to southern taiga zone) of Murmansk, Arkhangelsk Oblast and Republic of Komi. SOO were conducted according to the international protocol included in PPS Arctic Manual. SOO approaches based both on local people's perceptions and statistics help to identify main issues and targets for life quality, human capital and environment improvement and thus to distinguish leading SOO indicators for further monitoring. SOO have revealed close interaction between human resources, quality of life and environmental changes. Negative changes in human capital (depopulation, increasing unemployment, aging, declining physical and mental health, quality of education, loss of traditional knowledge, marginalization etc.), despite peoples' high creativity and optimism are becoming the major driving force effecting both the quality of life and the state of environment and overall sustainability. Human induced disturbances such as uncontrolled forests cuttings and poaching are increasing. Observed rapid changes in climate and biota (ice and permafrost melting, tundra shrubs getting taller and

Endogenous Tim-1 (Kim-1) promotes T-cell responses and cell-mediated injury in experimental crescentic glomerulonephritis.

Science.gov (United States)

Nozaki, Yuji; Nikolic-Paterson, David J; Snelgrove, Sarah L; Akiba, Hisaya; Yagita, Hideo; Holdsworth, Stephen R; Kitching, A Richard

2012-05-01

The T-cell immunoglobulin mucin 1 (Tim-1) modulates CD4(+) T-cell responses and is also expressed by damaged proximal tubules in the kidney where it is known as kidney injury molecule-1 (Kim-1). We sought to define the role of endogenous Tim-1 in experimental T-cell-mediated glomerulonephritis induced by sheep anti-mouse glomerular basement membrane globulin acting as a planted foreign antigen. Tim-1 is expressed by infiltrating activated CD4(+) cells in this model, and we studied the effects of an inhibitory anti-Tim-1 antibody (RMT1-10) on immune responses and glomerular disease. Crescentic glomerulonephritis, proliferative injury, and leukocyte accumulation were attenuated following treatment with anti-Tim-1 antibodies, but interstitial foxp3(+) cell accumulation and interleukin-10 mRNA were increased. T-cell proliferation and apoptosis decreased in the immune system along with a selective reduction in Th1 and Th17 cellular responses both in the immune system and within the kidney. The urinary excretion and renal expression of Kim-1 was reduced by anti-Tim-1 antibodies reflecting diminished interstitial injury. The effects of anti-Tim-1 antibodies were not apparent in the early phase of renal injury, when the immune response to sheep globulin was developing. Thus, endogenous Tim-1 promotes Th1 and Th17 nephritogenic immune responses and its neutralization reduces renal injury while limiting inflammation in cell-mediated glomerulonephritis.

Viscous flux flow velocity and stress distribution in the Kim model of a long rectangular slab superconductor

Science.gov (United States)

Yang, Yong; Chai, Xueguang

2018-05-01

When a bulk superconductor endures the magnetization process, enormous mechanical stresses are imposed on the bulk, which often leads to cracking. In the present work, we aim to resolve the viscous flux flow velocity υ 0/w, i.e. υ 0 (because w is a constant) and the stress distribution in a long rectangular slab superconductor for the decreasing external magnetic field (B a ) after zero-field cooling (ZFC) and field cooling (FC) using the Kim model and viscous flux flow equation simultaneously. The viscous flux flow velocity υ 0/w and the magnetic field B* at which the body forces point away in all of the slab volumes during B a reduction, are determined by both B a and the decreasing rate (db a /dt) of the external magnetic field normalized by the full penetration field B p . In previous studies, υ 0/w obtained by the Bean model with viscous flux flow is only determined by db a /dt, and the field B* that is derived only from the Kim model is a positive constant when the maximum external magnetic field is chosen. This means that the findings in this paper have more physical contents than the previous results. The field B* stress changing with decreasing field B a after ZFC if B* ≤ 0. The effect of db a /dt on the stress is significant in the cases of both ZFC and FC.

Helen Kim as New Woman and Collaborator: A Comprehensive Assessment of Korean Collaboration under Japanese Colonial Rule

Directory of Open Access Journals (Sweden)

AhRan Ellie Bae

2017-02-01

Full Text Available Although almost seventy years has passed since Korea's liberation from Japanese rule, the issue of collaboration still haunts Korea today. Attempts to resolve this issue have tended to focus attention on the traitorous actions of "collaborators" without considering the gray areas that surround their actions such as the circumstances that influenced the accused to commit their alleged traitorous acts and the intentions that drove their decisions. Helen Kim, as a "new woman" and an educator, valued the necessity of providing education for women. Yet, her efforts to realize this goal, to the contrary, forced her into actions that would later be used to construct a reputation as a Japanese collaborator. Korea's nationalist historiography has a tendency to polarize this issue by categorizing a "collaborator" as either a traitor or a patriot. However, when we take a closer look at these collaborators' lives, we discover that most collaboration happened in gray areas where it is often difficult to clearly draw a line between treason and collaboration. Helen Kim's case suggests that the issue of collaboration cannot be fully explained by nationalist historiography's framework and we must give attention to these gray areas. Through her story I hope to complicate the issue of collaboration by raising questions that address the gray areas that surround the actions of "collaborators." In doing so, I hope to challenge the nationalist historiography's propensity to oversimplify this issue and present a more nuanced understanding of it.

Oxidative stress by layered double hydroxide nanoparticles via an SFK-JNK and p38-NF-κB signaling pathway mediates induction of interleukin-6 and interleukin-8 in human lung epithelial cells

Directory of Open Access Journals (Sweden)

Choi SJ

2015-04-01

Full Text Available Soo-Jin Choi, Hee-Jeong Paek, Jin YuDepartment of Food Science and Technology, Seoul Women’s University, Seoul, Republic of KoreaAbstract: Anionic nanoclays are layered double hydroxide nanoparticles (LDH-NPs that have been shown to exhibit toxicity by inducing reactive oxidative species and a proinflammatory mediator in human lung epithelial A549 cells. However, the molecular mechanism responsible for this LDH-NP-induced toxicity and the relationship between oxidative stress and inflammatory events remains unclear. In this study, we focused on intracellular signaling pathways and transcription factors induced in response to oxidative stress caused by exposure to LDH-NPs in A549 cells. Mitogen-activated protein kinase (MAPK cascades, such as extracellular signal-regulated kinase, c-Jun-N-terminal kinase (JNK, and p38, were investigated as potential signaling mechanisms responsible for regulation of oxidative stress and cytokine release. Src family kinases (SFKs, which are known to mediate activation of MAPK, together with redox-sensitive transcription factors, including nuclear factor kappa B and nuclear factor-erythroid 2-related factor-2, were also investigated as downstream events of MAPK signaling. The results obtained suggest that LDH-NP exposure causes oxidative stress, leading to expression of antioxidant enzymes, such as catalase, glucose reductase, superoxide dismutase, and heme oxygenase-1, via a SFK-JNK and p38-nuclear factor kappa B signaling pathway. Further, activation of this signaling was also found to regulate release of inflammatory cytokines, including interleukin-6 and interleukin-8, demonstrating the inflammatory potential of LDH-NP.Keywords: layered double hydroxide, mitogen-activated protein kinases, Src family kinases, nuclear factor kappa B, oxidative stress, inflammatory cytokine

金批«西厢»美学论%On Aesthetic Thought of Jin Shengtan’ s Comments on The Romance of West Chamber

Institute of Scientific and Technical Information of China (English)

周锡山

2013-01-01

在全面论述金圣叹戏曲美学的基础上，着重论述其“天人合一”、“无和梦”、“通鬼神”和“文有魂”等观点。这些重要观点是以儒、道、佛三家的哲学结合其心得体会而论述的，故而取得了精深的成就。金批«西厢»的鉴赏论是针对普通读者的，艺术论是兼顾读者和作家的，美学论是针对文化修养高的欣赏者和作家诗人的；以上美学观点的阐发，则更是针对文化修养极高的鉴赏者和诗人作家的，高深而玄妙，需要长期反复学习、体会才能掌握。%Based on the comprehensive discussion on Jin Shengtan’ s opera aesthetics,the paper focuses on the theory that heaven-man integration,nature and literature creation, nothing and dream, intercommunion with supernatural beings, and the soul in the article. The above views are put forward with combination of Confucianism,Taoism and Buddhism and Jin’ s own stud-y,and accordingly,Jin made profound achievements. Jin’ s appreciation theory on The Romance of West Chamber is aimed at the common readers;his art theory is aimed at both readers and writers; and his aesthetics is aimed at writers and poets with great accomplishments. The paper holds that the explorations of the above aesthetics are aimed at appreciators, writers and poets with great accomplishments,which needs to be repeatedly and further studied.

An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007).

OpenAIRE

Alzo David-West

2013-01-01

This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses...

Colon-targeted delivery of budesonide using dual pH- and time-dependent polymeric nanoparticles for colitis therapy

Directory of Open Access Journals (Sweden)

Naeem M

2015-07-01

Full Text Available Muhammad Naeem,1 Moonjeong Choi,1 Jiafu Cao,1 Yujeong Lee,1 Muhammad Ikram,2 Sik Yoon,2 Jaewon Lee,1 Hyung Ryong Moon,1 Min-Soo Kim,1 Yunjin Jung,1 Jin-Wook Yoo11College of Pharmacy, Pusan National University, Busan, 2Pusan National University School of Medicine, Yangsan, South KoreaAbstract: Single pH-dependent drug delivery systems have been widely used for colon-targeted delivery, but their efficiency is often hampered by the variation in gut pH. To overcome the limitation of single pH-dependent delivery systems, in this study, we developed and evaluated the therapeutic potential of budesonide-loaded dual pH/time-dependent nanoparticles (NPs for the treatment of colitis. Eudragit FS30D was used as a pH-dependent polymer, and Eudragit RS100 as a time-dependent controlled release polymer. Single pH-dependent NPs (pH_NPs, single time-dependent NPs (Time_NPs, and dual pH/time-dependent NPs (pH/Time_NPs were prepared using the oil-in-water emulsion method. The physicochemical properties and drug release profiles of these NPs in gastrointestinal (GI tract conditions were investigated. The therapeutic potential and in vivo distribution of the NPs were evaluated in a dextran sulfate sodium (DSS-induced colitis mice model. The pH/Time_NPs prevented a burst drug release in acidic pH conditions and showed sustained release at a colonic pH. The in vivo distribution study in the mice GI tract demonstrated that pH/Time_NPs were more efficiently delivered to the inflamed colon than pH_NPs were. Compared to the single pH_NPs-treated group, the pH/Time_NPs-treated group showed increased body weight and colon length and markedly decreased disease activity index, colon weight/length ratios, histological damage, and inflammatory cell infiltration in colon tissue. Our results demonstrate that the dual pH/time-dependent NPs are an effective oral colon-targeted delivery system for colitis therapy.Keywords: colon-specific delivery, dual-sensitive delivery

TERT-CLPTM1 locus polymorphism (rs401681 is associated with the prognosis of hepatocellular carcinoma

Directory of Open Access Journals (Sweden)

Lee HW

2017-10-01

Full Text Available Hye Won Lee,1,* Won-Jin Park,2,* Yu-Ran Heo,2 Tae In Park,3 Soo Young Park,4 Jae-Ho Lee2,* 1Department of Pathology, Keimyung University School of Medicine, Daegu, Republic of Korea; 2Department of Anatomy, Keimyung University School of Medicine, Daegu, Republic of Korea; 3Department of Pathology, Kyungpook National University School of Medicine, Daegu, Republic of Korea; 4Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu, Republic of Korea *These authors contributed equally to this work Abstract: Telomere length is associated with the development of hepatocellular carcinoma (HCC, and recent studies have focused on the genetic alteration or polymorphism in telomere-maintaining genes. We examined the clinicopathologic and prognostic value of rs401681 polymorphism, located in the TERT-CLPTM1L locus, in HCC. The relationship between rs401681 variants and telomere length was also analyzed in 156 HCC patients. The rs401681 polymorphism had the following genotype frequencies: C/C in 51.3% of the samples, C/T in 39.7%, and T/T in 9.0%. Telomeres in the tumor samples were 4.04-fold longer, on average, than the telomeres in matched normal samples (SD =1.32, and there were no differences in telomere length according to rs401681 polymorphism (p=0.802. Our results indicate that the rs401681 C allele was significantly associated with increased T and International Union for Cancer Control stages (p<0.01. Univariate and multivariate survival analyses showed that HCC with C allele had poorer prognosis (p<0.01. In conclusion, our findings suggest that rs401681 is a possible prognostic biomarker for HCC patients. Keywords: CLPTM1L polymorphism, hepatocellular carcinoma, TERT-CLPTM1L locus, telomere length

Missionary Medicine of Canadian Presbytery and Korean Doctors under Japanese Occupation - focusing Sung-jin and Ham-heung

Directory of Open Access Journals (Sweden)

Yun-Jung HEO

2015-12-01

��women’s work’ as McMillan did. Korean doctors and assistants who worked at the mission hospitals had seen the spread of Protestantism in their youth; had received modern education; had experienced the fall of own country in 1910 and nationwide protest against Japan in 1919. The majority of them were graduates of Severance Medical College, the hub of missionary medicine at the time. After the resignation from the mission hospitals, 80 percent of them became self-employed general practitioners. The operations of the mission hospitals began to contract in 1930 due to tightened control by Imperial Japan. Shrine worship imposed on Christians caused internal conflict and division among missionaries and brought about changes in the form and contents of the mission organization. The incidence of the assault of Dr. Grieson brought about the dissolution of Sung-jin mission base and the interruption of the operation of Je-dong Hospital. As the Pacific War expanded, missionaries were driven out of Korea and returned home. In conclusion, the missions work by Canadian Presbytery missionaries had greatly impacted Protestantism in Korea. The characteristics of Canadian Presbytery were manifested in their support of Korean nationalism movement, openness for Social Gospel, and maintaining equal footing with Korean Christians. Specifically we note the influence of these characteristics in Chosun doctors who had worked in the mission hospitals. They operated their own hospitals or clinics in a manner similar to the mission hospitals by providing treatment for poor patients free of charge or for a nominal fee and treating the patients in a kind and humanistic way. After the 1945 Liberation, Korean doctors’career paths split into two directions. most of them defected to South Korea and chose the path to work as general practitioners. A few of them remained in North Korea and became educator of new doctors. It is meaningful that former doctors of Canadian missionary hosptal became dean of 2

[Missionary Medicine of Canadian Presbytery and Korean Doctors under Japanese Occupation--focusing Sung-jin and Ham-heung].

Science.gov (United States)

Heo, Yun-Jung; Cho, Young-Soo

2015-12-01

. Korean doctors and assistants who worked at the mission hospitals had seen the spread of Protestantism in their youth; had received modern education; had experienced the fall of own country in 1910 and nationwide protest against Japan in 1919. The majority of them were graduates of Severance Medical College, the hub of missionary medicine at the time. After the resignation from the mission hospitals, 80 percent of them became self-employed general practitioners. The operations of the mission hospitals began to contract in 1930 due to tightened control by Imperial Japan. Shrine worship imposed on Christians caused internal conflict and division among missionaries and brought about changes in the form and contents of the mission organization. The incidence of the assault of Dr. Grieson brought about the dissolution of Sung-jin mission base and the interruption of the operation of Je-dong Hospital. As the Pacific War expanded, missionaries were driven out of Korea and returned home. In conclusion, the missions work by Canadian Presbytery missionaries had greatly impacted Protestantism in Korea. The characteristics of Canadian Presbytery were manifested in their support of Korean nationalism movement, openness for Social Gospel, and maintaining equal footing with Korean Christians. Specifically we note the influence of these characteristics in Chosun doctors who had worked in the mission hospitals. They operated their own hospitals or clinics in a manner similar to the mission hospitals by providing treatment for poor patients free of charge or for a nominal fee and treating the patients in a kind and humanistic way. After the 1945 Liberation, Korean doctors'career paths split into two directions. most of them defected to South Korea and chose the path to work as general practitioners. A few of them remained in North Korea and became educator of new doctors. It is meaningful that former doctors of Canadian missionary hosptal became dean of 2 medical colleges among 3 of all

The trouble with halos: invited commentary on Kim, S., & Harris, P. L. (2014). Children prefer to learn from mind-readers. British Journal of Developmental Psychology.

Science.gov (United States)

Richert, Rebekah A

2014-11-01

This commentary on Kim and Harris (2014) addresses the authors' interpretation of the halo effect, in which 5- to 6-year-old children preferentially agreed with an informant who could read other people's minds, regardless of domain of knowledge. © 2014 The British Psychological Society.

KANUNISASI FIKIH JINAYAT KONTEMPORER Studi Materi Muatan Qānūn Jināyat Aceh dan Brunei Darussalam

Directory of Open Access Journals (Sweden)

Samsudin Aziz

2014-10-01

Full Text Available This article will view specifically codification of Islamic Criminal Law in `Muslim community, such as Brunei Darussalam, a country based on Islamic principles, and Aceh is a part of Indonesian territory administratively, granted special autonomy to implement Islamic Sharia. Despite having different qualities, -as a country and a province- both have in common as a political power which apply Islamic Criminal Law. Refer to both qānūn jināyat in Brunei and Aceh, the author’ll explain the substance of the criminal law in both area, while also reinforces the implementation of Islamic Criminal Law in the framework of a modern state. The article concludes that basically the application of Islamic Sharia, particularly the Islamic Criminal Law, is closely related to the situation and socio-political conditions of a community or country. The differences of political system, for example, has contributed to the difference in the output of product or policy made by a particular country or territory. On the other hand, Brunei and the Aceh case show that there has been adjustment Islamic Criminal Law specifically set forth in the books of fiqh (as illustration of the Qur'an and Sunnah with the needs of the community itself

Can You Anchor a Shimmering Nation State via Regional Indigenous Roots? Kim Scott talks to Anne Brewster about That Deadman Dance

Directory of Open Access Journals (Sweden)

Anne Brewster

2011-10-01

Full Text Available This interview focuses mainly on Kim Scott’s new novel That Deadman Dance which won the regional Commonwealth Writers Prize (Southeast Asian and Pacific region and the Miles Franklin Award. The topics of conversation include Scott’s involvement in the Noongar language project (and the relationship of this project to the novel, the novel itself, the challenges of writing in English, the resistance paradigm and indigenous sovereignty and nationalism.

Die dagboek van Bertha Marks as ‘n heterotopia, soos verwoord in die kunswerk, The Futility of Writing 24-Page Letters

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Leora Farber

2012-11-01

Full Text Available Hierdie artikel ondersoek die konsepsie, historiese konteks en teoretiese raamwerk van Leora Farber se 2010 kunswerk The Futility of Writing 24-Page Letters wat ‘n voortsetting is van haar uitstalling Dis-Location/Re-Location. The Futility of Writing 24-Page Letters val binne die tematiek van Dis-Location/Re-Location, maar beklemtoon één aspek van laasgenoemde, naamlik hoe fin-de-siècle Joodse koloniale immigrante vrouens in Suiderlike-Afrika – soos versinnebeeld in die persona van Bertha Marks (1862–1934 – negentiende-eeuse, Viktoriaanse genderideologieë ervaar het. Hierdie vrouens se lewenservarings het dikwels verset teenoor hul posisies as subjekte van ‘n patriargale sosiale sisteem behels, tog, as vrouens, was hul tegelykertyd medepligtig aan die onderskraging van diskriminerende koloniale ideologieë, en aan die handhawing van die rasse, sosiale en kulturele vooroordele, asook vorms van onderdrukking, wat hierdie ideologieë ingelig het. Daar word geargumenteer dat Bertha Marks ‘n verpersoonlikte heterotopia bewoon het; terwyl sy haar plek binne die struktuur van die rasse- en sosiale vooroordele van die koloniale tydperk ten volle ingeneem het, was sy terselfdertyd beperk deur haar posisionering binne dié raamwerk. Hierdie heterotopiese lewenservaring word weerspieël in die dagboekuittreksels waaruit The Futility of Writing 24-Page Letters bestaan. Daarin word haar teenstrydige posisies as slagoffer, getuie, bystander, meeloper en begunstigde van koloniale onreg en uitbuiting geopenbaar, en aanvaar sy in wisselende mate mede-verantwoordelikheid en mede-aanspreeklikheid vir haar rol en optrede.

Baseline characteristics and response to 2 years of growth hormone (GH) replacement of hypopituitary patients with GH deficiency due to adult-onset craniopharyngioma in comparison with patients with nonfunctioning pituitary adenoma: data from KIMS (Pfizer International Metabolic Database).

Science.gov (United States)

Verhelst, Johan; Kendall-Taylor, Pat; Erfurth, Eva Marie; Price, David Anthony; Geffner, Mitchell; Koltowska-Häggström, Maria; Jönsson, Peter J; Wilton, Patrick; Abs, Roger

2005-08-01

In epidemiological studies, hypopituitary adults show increased mortality compared with population controls. Patients with hypopituitarism caused by a craniopharyngioma (CP) and/or its treatment have a higher mortality than patients with other etiologies, such as a nonfunctioning pituitary adenoma (NFPA). To analyze this difference, we used the KIMS database (Pfizer International Metabolic Database) comparing CP and NFPA patients in terms of baseline characteristics and responses to GH replacement. Baseline characteristics were studied in 351 CP patients (189 men and 162 women; mean age, 42.5 yr) and compared with 370 NFPA patients, matched for age and sex (185 men and 185 women; mean age, 42.5 yr). The effects of 2 yr of GH replacement were analyzed in a subgroup of 183 CP and 209 NFPA patients. At baseline, both CP and NFPA patients had characteristic features of GH deficiency, with low serum IGF-I, increased body fat, dyslipidemia, and reduced quality of life. Male CP patients were significantly more obese (30.0 vs. 28.2 kg/m2; P = 0.0003) compared with NFPA patients, had a higher waist/hip ratio (P = 0.004), higher triglycerides (P = 0.003), and lower high-density lipoprotein cholesterol (P = 0.03). Similar, but much smaller, differences were seen in female CP compared with NFPA patients, only reaching significance for waist/hip ratio (P = 0.05) and triglycerides (P = 0.0004). CP patients had more often undergone surgery by the transcranial route (68.8% vs. 30.9%; P NFPA patients (58.7% vs. 19.8%; P NFPA patients. After 2 yr of GH replacement therapy, similar significant improvements were evident in both groups in fat-free mass, total and low-density lipoprotein cholesterol, and Quality-of-Life-Assessment in GH Deficient Adults score compared with baseline. In contrast to NFPA patients, CP patients had no significant decrease in body fat with GH therapy. In the KIMS database, patients with CP have more often undergone surgery by the transcranial route than

A STUDY OF MICROBES IN FRUIT JUICES, KIMS-AMALAPURAM

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Nagaraja

2015-12-01

Full Text Available INTRODUCTION Fruit and sugarcane juices are nutritious drinks with great taste and health benefits. Food borne illnesses associated with consumption of Fruit and sugarcane juices at several places in India and elsewhere. Fruit juices were served with added ice pieces. Hygienic standards are not maintained while transporting from the field to the place of extraction and preparation. Hence a rapid review of the fruit juices from street vendors has been undertaken along with sugarcane juice. Raw sugarcane juice is a refreshing juice in many parts of Andhra Pradesh. The present study is to assess the prevalence of different organisms from different fruit juices collected from street vendors. METHODS Fruit juices are collected namely sugarcane, sweet lemon, orange, grape apple, pineapple pomegranate. A total 100 samples of fruit juices were collected from road side from different vendors. 150 ml of each variety of fruit juices were collected from different vendors in screw capped bottles and subjected to microbial analysis, processed with in 30mts in the department of microbiology at KIMS by standard methods. RESULTS The analysed samples of fruit juices are found to be contaminated with different bacteria, Escherichia coli 30% Klebsiella pneumoniae 10% Staphylococcus aureus 20% Enterococcus faecalis 04% Pseudomonas aeruginosa 10% ASB 04% (aerobic spore bearers Micrococci 02% Proteus 20% Salmonella. Shigella and Vibrios were not isolated. CONCLUSION It is high time that street vendors should have health education by volunteers, health workers from PHC (primary health centers and people well versed with community medicine practice for implementation of standard hygienic protocols may reduce contamination of fruit and sugarcane juices The concerned health authorities need to ensure and insist to follow the protocols by the vendors and license holders to the vendors.

Evaluation of a commercially available ELISA kit for quantifying imidacloprid residues in Erthrina sandwicensis leaves for management of the Erythrina gall wasp, Quadrastichus erythrinae Kim.

Science.gov (United States)

Joseph Fischer; Brian Strom; Sheri Smith

2009-01-01

The erythrina gall wasp (EGW), Quadrastichus erythrinae Kim 2004, was first detected in Hawaii in 2005 and has been infesting and killing Erythrina trees throughout the island chain since. It is believed EGW originated from Africa (Messing et al. 2009). Its host range appears to be limited to Erythrina; its...

In vitro cytotoxicity of SiO2 or ZnO nanoparticles with different sizes and surface charges on U373MG human glioblastoma cells

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Kim JE

2014-12-01

Full Text Available Jung-Eun Kim,1,* Hyejin Kim,1,* Seong Soo A An,2 Eun Ho Maeng,3 Meyoung-Kon Kim,4 Yoon-Jae Song1 1Department of Life Science, 2Department of Bionano Technology, Gachon University, Seongnam-Si, South Korea; 3Korea Testing and Research Institute, Seoul, South Korea; 4Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea *These authors contributed equally to this work Abstract: Silicon dioxide (SiO2 and zinc oxide (ZnO nanoparticles are widely used in various applications, raising issues regarding the possible adverse effects of these metal oxide nanoparticles on human cells. In this study, we determined the cytotoxic effects of differently charged SiO2 and ZnO nanoparticles, with mean sizes of either 100 or 20 nm, on the U373MG human glioblastoma cell line. The overall cytotoxicity of ZnO nanoparticles against U373MG cells was significantly higher than that of SiO2 nanoparticles. Neither the size nor the surface charge of the ZnO nanoparticles affected their cytotoxicity against U373MG cells. The 20 nm SiO2 nanoparticles were more toxic than the 100 nm nanoparticles against U373MG cells, but the surface charge had little or no effect on their cytotoxicity. Both SiO2 and ZnO nanoparticles activated caspase-3 and induced DNA fragmentation in U373MG cells, suggesting the induction of apoptosis. Thus, SiO2 and ZnO nanoparticles appear to exert cytotoxic effects against U373MG cells, possibly via apoptosis. Keyword: apoptosis

Report on visit from Prof. Kim Lutzen: Friday, 6 November 1998, Korolinska Institute (dept of nursing Stockholm, Sweden

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Kim Lutzen

1999-10-01

Full Text Available Prof. Kim Lutzen contacted the Department of Advanced Nursing Sciences, Unisa, via the Department's Web Page. Prof. Lutzen is the Chair of the Department of Nursing, which offers undergraduate, master and doctoral programmes. This Department of Nursing is situated within the Karolinska Institute, which comprises 29 Departments of Health Sciences, including a number of Medical Departments, Dentistry, Occupational Therapy, Physiotherapy, and Nursing. Prof. Lutzen emphasised that there is no Swedish phrase similar to "nursing science", consequently this t e n seems to be somewhat unfamiliar to the Swedish nurses. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

Prospects for 6-party talks: Nuclear weapons are a means of survival for Kim Jong Un

International Nuclear Information System (INIS)

Miyake, Kunihiko

2012-04-01

The author considers the impact of leader Kim Jong Il's death on 6-party talks surrounding the nuclear issue. Firstly, the history of these 6-party talks has to be reexamined to ensure an accurate understanding of their 'objectives and limitations' because the author believes that there are 3 'unpleasant truths' behind these talks, held 6 times since the summer of 2003, that no one wants to talk about. 1. North Korea has no interest in abandoning nuclear weapons; 2. Japan, the U.S., China, and South Korea do not want war; 3. The nuclear issue will not be resolved by 6-party talks. In fact, there is little potential that 6-party talks which aim to resolve the North Korean nuclear issue will move towards a new substantive agreement

The complete larval development of Eurypanopeus canalensis Abele and Kim, 1989 (Crustacea: Brachyura: Panopeidae described from laboratory reared material

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Marcelo U. García-Guerrero

2005-09-01

Full Text Available The estuarine panopeid crab Eurypanopeus canalensis Abele and Kim, 1989, is an eastern tropical Pacific species with a known distribution from the southeastern Gulf of California, Mexico, to Panama. Its complete larval development is fully described and illustrated from laboratory-reared material. The four zoeal stages and the megalopa are compared with two congeneric species from the West Atlantic, E. abbreviatus (Stimpson, 1860 and E. depressus (Smith, 1869. The main differences between larvae of E. canalensis and those of these two species include telson setation and the presence/absence of a stout hook-like spine in the megalopae cheliped ischium.

The Expression of the Femininity and Imperialism : Through comparison study of works of Toshiko Tamura and Myung-soon Kim

OpenAIRE

金, 玟妵

2005-01-01

Toshiko Tamura and Myung-soon Kim flourished in 1910-20 in Japan and Korea. In those days it was an act of a man to write. The feminine was demanded above all to the thing which a woman wrote by the literary world and the society, so that woman does not invade a domain of a man. A lot of studies about that the motherhood is one of a model of feminine, it was used to mobilize a woman for war, while militarism advances. Then is what kind of position was there the femininity at socially and cult...

AXENIC IN-VITRO NITROGEN AND PHOSPHORUS RESPONSES OF SOME DUTCH MARSH ORCHIDS

NARCIS (Netherlands)

DIJK, E; ECK, N

1995-01-01

Seedlings of Dactylorhiza majalis (Reichb.) Hunt & Summerh., D. praetermissa (Druce) Soo var.junialis (Vermen.) Sengh., D. incarnata (L.) Soo and D. maculata (L.) Soo ssp. maculata were grown axenically in vitro at various concentrations of ammonium nitrate and phosphate to assess the extent of

Data and statistical summaries of background concentrations of metals in soils and streambed sediments in part of Big Soos Creek drainage basin, King County, Washington

Science.gov (United States)

Prych, E.A.; Kresch, D.L.; Ebbert, J.C.; Turney, G.L.

1995-01-01

Twenty-nine soil samples from 14 holes at 9 sites in part of the Big Soos Creek drainage basin in southwest King County, Washington, were collected and analyzed to obtain data on the magnitude and variability of background concentrations of metals in soils. Seven streambed-sediment samples and three streamwater samples from three sites also were collected and analyzed. These data are needed by regulating government agencies to determine if soils at sites of suspected contamination have elevated concentrations of metals, and to evaluate the effectiveness of remediation at sites with known contamination. Concentrations of 43 metals were determined by a total method, and concentrations of 17 metals were determined by a total-recoverable method and two different leaching methods. Metals analyzed for by all methods included most of those on the U.S. Environmental Protection agency list of priority pollutants, plus alluminum, iron, and manganese. Ranges of concentrations of metals determined by the total method are within ranges found by others for the conterminous United States. Concentrations of mercury, manganese, phosphorus, lead, selenium, antimony, and zinc as determined by the total method, and of some of these plus other metals as determined by the other methods were larger in shallow soil (less than 12 inches deep) than in deep soil (greater than 12 inches). Concentrations of metals in streambed sediments were more typical of shallow than deep soils.

Core Self-Evaluations as Personal Factors in the World Health Organization's International Classification of Functioning, Disability and Health Model: An Application in Persons with Spinal Cord Injury

Science.gov (United States)

Yaghmanian, Rana; Smedema, Susan Miller; Thompson, Kerry

2017-01-01

Purpose: To evaluate Chan, Gelman, Ditchman, Kim, and Chiu's (2009) revised World Health Organization's International Classification of Functioning, Disability and Health (ICF) model using core self-evaluations (CSE) to account for Personal Factors in persons with spinal cord injury (SCI). Method: One hundred eighty-seven adults with SCI were…

Association of urinary KIM-1, L-FABP, NAG and NGAL with incident end-stage renal disease and mortality in American Indians with type 2 diabetes mellitus.

Science.gov (United States)

Fufaa, Gudeta D; Weil, E Jennifer; Nelson, Robert G; Hanson, Robert L; Bonventre, Joseph V; Sabbisetti, Venkata; Waikar, Sushrut S; Mifflin, Theodore E; Zhang, Xiaoming; Xie, Dawei; Hsu, Chi-Yuan; Feldman, Harold I; Coresh, Josef; Vasan, Ramachandran S; Kimmel, Paul L; Liu, Kathleen D

2015-01-01

Kidney injury molecule 1 (KIM-1), liver fatty acid-binding protein (L-FABP), N-acetyl-β-D-glucosaminidase (NAG) and neutrophil gelatinase-associated lipocalin (NGAL) are urinary biomarkers of renal tubular injury. We examined their association with incident end-stage renal disease (ESRD) and all-cause mortality in American Indians with type 2 diabetes. Biomarker concentrations were measured in baseline urine samples in 260 Pima Indians who were followed for a median of 14 years. HRs were reported per SD of creatinine (Cr)-normalised log-transformed KIM-1, NAG and NGAL, and for three categories of L-FABP. During follow-up, 74 participants developed ESRD and 101 died. Median concentrations of KIM-1/Cr, NAG/Cr and NGAL/Cr and the proportion of detectable L-FABP were highest in those with macroalbuminuria (p associated with ESRD (HR 1.59, 95% CI 1.20, 2.11) and mortality (HR 1.39, 95% CI 1.06, 1.82); L-FABP/Cr was inversely associated with ESRD (HR [for highest vs lowest tertile] 0.40, 95% CI 0.19, 0.83). Addition of NGAL/Cr to models that included albuminuria and glomerular filtration rate increased the c-statistic for predicting ESRD from 0.828 to 0.833 (p = 0.001) and for death from 0.710 to 0.722 (p = 0.018). Addition of L-FABP/Cr increased the c-statistic for ESRD from 0.828 to 0.832 (p = 0.042). In Pima Indians with type 2 diabetes, urinary concentrations of NGAL and L-FABP are associated with important health outcomes, but they are unlikely to add to risk prediction with standard markers in a clinically meaningful way given the small increase in the c-statistic.

International Conference on Coherence and Quantum Optics

CERN Document Server

RECENT DEVELOPMENTS IN QUANTUM OPTICS

1993-01-01

This volume is composed of papers (invited and contributed) presented at the International Conference on Coherence and Quantum Optics held at the University of Hyderabad January 5-January 10, 1991. It has been organized by Professor Girish Agarwal and his colleagues at the School of Physics, University of Hyderabad, Hyder­ abad, India under partial support from the Department of Science and Technology, Government of India, International Center for Theoretical Physics, Trieste, Italy and the National Science Foundation, USA. Without the untiring efforts of Prof. Girish Agarwal and the members of his quantum office group, the Conference and the present volume would not have been possible. Some extraordinary circumstances resulted in a delay of the publication of the present volume. Our sincere apologies to all the authors. We deeply regret the inconvenience caused due to the delay. A debt of gratitude is due to Ms. Kim Bella for the excellent typing job of the different versions and the final version of the ma...

KIM, Steady-State Transport for Fixed Source in 2-D Thermal Reactor by Monte-Carlo

International Nuclear Information System (INIS)

Cupini, E.; De Matteis, A.; Simonini, R.

1980-01-01

1 - Description of problem or function: KIM (K-infinite Monte Carlo) is a program which solves the steady-state linear transport equation for a fixed-source problem (or, by successive fixed-source runs, for the eigenvalue problem) in a two-dimensional infinite thermal reactor lattice. The main quantities computed in some broad energy groups are the following: - Fluxes and cross sections averaged over the region (i.e. a space portion that can be unconnected but contains everywhere the same homogeneous material), grouping of regions, the whole element. - Average absorption and fission rates per nuclide. - Average flux, absorption and production distributions versus energy. 2 - Method of solution: Monte Carlo simulation is used by tracing particle histories from fission birth down through the resonance region until absorption in the thermal range. The program is organised in three sections for fast, epithermal and thermal simulation, respectively; each section implements a particular model for both numerical techniques and cross section representation (energy groups in the fast section, groups or resonance parameters in the epithermal section, points in the thermal section). During slowing down (energy above 1 eV) nuclei are considered as stationary, with the exception of some resonance nuclei whose spacing between resonances is much greater than the resonance width. The Doppler broadening of s-wave resonances of these nuclides is taken into account by computing cross sections at the current neutron energy and at the temperature of the nucleus hit. During thermalization (energy below 1 eV) the thermal motion of some nuclides is also considered, by exploiting scattering kernels provided by the library for light water, heavy water and oxygen at several temperatures. KIM includes splitting and Russian roulette. A characteristic feature of the program is its approach to the lattice geometry. In fact, besides the usual continuous treatment of the geometry using the well

Impacts of Land-Use and Land-Cover Changes on Water Yield: A Case Study in Jing-Jin-Ji, China

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Suxiao Li

2018-03-01

Full Text Available Knowing the impact of land-use and land-cover (LULC changes on the distribution of water yield (WY is essential for water resource management. Using the Integrated Valuation of Ecosystem Services and Tradeoffs (InVEST model, we investigated the spatial-temporal variations of WY from 1990 to 2015 in China’s northern semi-arid region of Beijing–Tianjin–Hebei (Jing-Jin-Ji. We quantified the combined effects of LULC dynamics and climatic variation on WY. Furthermore, we identified the relative contribution of main LULC types to WY. For our study region, the built-up area increased by 35.66% (5380 km2 during the study period. In the meantime, cropland, grassland, and wetland decreased continuously. The expansion of built-up area and decline of vegetated land led to an increase of 1047 million m3 (5.1% in total WY. The impacts of LULC changes on WY were mainly determined by the biophysical characteristics of LULC composition. Vegetated land has relatively lower WY coefficients due to higher rates of evapotranspiration and water infiltration. Built-up areas and bare land have higher WY coefficients as a result of their impermeable surface. The spatial-temporal analysis of WY with specification of WY coefficients by LULC types can facilitate integrated land-use planning and water resource management.

The prevalence of musculoskeletal disorders and occupational risk factors in Kashan SAIPA automobile industry workers by key indicator method (KIM, 1390

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2012-05-01

Full Text Available Introduction: work related musculoskeletal disorders are the most wide spread type of occupational diseases among workers. Awkward body postures during work and manual material handling are among the most important risk factors of musculoskeletal disorders in different jobs. Due to importance of recognizing these factors prevalence and risk factor of work related musculoskeletal disorders, this research was aimed to study the among employees of Kashan City’s Saipa automobile industry in 2011. .Material and Method: This study is a descriptive-cross sectional study conducted among workers with manual material handling 37 activities and 84 work duties. To recognize musculoskeletal disorders, body map questionnaire was applied and occupational risk factors were evaluated using Key Index Method (KIM. Data was analyzed using SPSS and Excel software. .Result: Highest prevalence of musculoskeletal disorders was in low and upper back region (%92. Based on the results from KIM, workers in the installing the tire, shuttle-aided fitting of seat, and engine work station had higher risk level with the scores of 66, 52 and 52, respectively. Risk level among three individuals (%3.6 was at 1, 40 (%47.6 at 2, 38 (%45.2 risk level 3, and 3 (%3.6 at 4. .Conclusion: Awkward body posture, improper twisting and flexion of low back were major risk factor among worker doing manual material handling tasks. Regarding the high prevalence of musculoskeletal disorders, appropriate ergonomic interventions such as engineering and organization interactions can reduce this risk factors (posture, heavy load, duration, workplace conditions as much as the risk level reach to an acceptable level.

The effect of neutral-surface iron oxide nanoparticles on cellular uptake and signaling pathways

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Kim E

2016-09-01

Full Text Available Eunjoo Kim,1 Joon Mee Kim,2 Lucia Kim,2 Suk Jin Choi,2 In Suh Park,2 Jee Young Han,2 Young Chae Chu,2 Eun Sook Choi,1 Kun Na,3 Soon-Sun Hong4 1Division of Nano and Energy Convergence Research, Daegu Gyeongbuk Institute of Science and Technology (DGIST, Daegu, 2Department of Pathology, Inha University College of Medicine, Incheon, 3Department of Biotechnology, Catholic University of Korea, Bucheon, 4Department of Biomedical Sciences, Inha University College of Medicine, Incheon, South Korea Abstract: In recent years, iron oxide nanoparticles (IONPs have been applied widely to biomedical fields. However, the relationship between the physicochemical properties of IONPs and their biological behavior is not fully understood yet. We prepared 3-methacryloxypropyl­trimethoxysilane (MPS-coated IONPs, which have a neutral hydrophobic surface, and compared their biological behavior to that of Resovist (ferucarbotran, a commercialized IONP formulation modified with carboxymethyl dextran. The rate of MPS-IONP uptake by human aortic endothelial cells (HAoECs was higher than ferucarbotran uptake, indicating that the neutral hydrophobic nature of MPS-IONPs allowed them to be absorbed more readily through the plasma membrane. However, the signaling pathways activated by MPS-IONPs and ferucarbotran were comparable, suggesting that surface charge is not a key factor for inducing changes in HAoECs. In vivo fate analysis showed that MPS-IONPs accumulated for longer periods in tissues than hydrophilic ferucarbotran. These findings could enlarge our understanding of NP behavior for advanced applications in the biomedical field. Keywords: iron oxide nanoparticles, neutral hydrophobic surface, signaling pathway, uptake, accumulation, reactive oxygen species (ROS

Using the Light Microscopy Module (LMM) on the International Space Station (ISS), The Advanced Colloids Experiment (ACE) and MacroMolecular Biophysics (MMB)

Science.gov (United States)

Meyer, William; Foster, William M.; Motil, Brian J.; Sicker, Ronald; Abbott-Hearn, Amber; Chao, David; Chiaramonte, Fran; Atherton, Arthur; Beltram, Alexander; Bodzioney, Christopher M.;

Candidate genes for COPD: current evidence and research

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Kim WJ

2015-10-01

Full Text Available Woo Jin Kim,1 Sang Do Lee2 1Department of Internal Medicine and Environmental Health Center, Kangwon National University, Chuncheon, 2Department of Pulmonary and Critical Care Medicine, Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea Abstract: COPD is a common complex disease characterized by progressive airflow limitation. Several genome-wide association studies (GWASs have discovered genes that are associated with COPD. Recently, candidate genes for COPD identified by GWASs include CHRNA3/5 (cholinergic nicotine receptor alpha 3/5, IREB2 (iron regulatory binding protein 2, HHIP (hedgehog-interacting protein, FAM13A (family with sequence similarity 13, member A, and AGER (advanced glycosylation end product–specific receptor. Their association with COPD susceptibility has been replicated in multiple populations. Since these candidate genes have not been considered in COPD, their pathological roles are still largely unknown. Herein, we review some evidences that they can be effective drug targets or serve as biomarkers for diagnosis or subtyping. However, more study is required to understand the functional roles of these candidate genes. Future research is needed to characterize the effect of genetic variants, validate gene function in humans and model systems, and elucidate the genes’ transcriptional and posttranscriptional regulatory mechanisms. Keywords: chronic obstructive pulmonary disease, genetics, genome-wide association study

Moral is political Notions of ideal citizenship in Lie Kim Hok’s Hikajat Khonghoetjoe

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Evi Sutrisno

2017-04-01

Full Text Available This paper argues that the Hikajat Khonghoetjoe (The life story of Confucius, written by Lie Kim Hok in 1897, is a medium to propose modern ideas of flexible subjectivity, cosmopolitanism, active citizenship and the concepts of good governance to the Chinese Peranakans who experienced political and racial discrimination under Dutch colonization. Using the figure of Confucius, Lie aimed to cultivate virtuous subjects who apply their faith and morality in political sphere. He intended to raise political awareness and rights among the Chinese as colonial subjects and to valorize their bargaining power with the Dutch colonial government. By introducing Confucianism, Lie proposed that the Chinese reconnect themselves with China as an alternative patronage which could subvert White supremacy. Instead of using sources in Chinese, Lie translated the biography of Confucius from the European texts. In crafting his story, Lie applied conglomerate authorship, a technique commonly practised by Malay authors. It allowed him to select, combine and appropriate the source texts. To justify that Confucius' virtue and his teaching were superb and are applicable to contemporary life, Lie borrowed and emphasized European writers’ high appraisal of Confucianism, instead of using his own arguments and opinions. I call this writing technique “indirect agency”.

An Inquiry of Intentions in Kim Hye-yong's 'First Meeting': A North Korean Short Story in Korea Today (2007.

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Alzo David-West

2013-11-01

Full Text Available This paper examines the problem of the intentional fallacy in the North Korean short story 'First Meeting' by Kim Hye-yong. Serially published in Korea Today in 2007, the nationalist allegory centres on Shin Ch'ong-mi, a young female journalist in Pyongyang, who falls in love with her penfriend Song-u, a soldier in the Korean People's Army, and struggles to remain devoted to him when he suddenly stops writing. With the literary-critical method of counterintuitive reading, the inquiry analyses the structural relations of the narrative, its discourse on desire, its apparent intentions, and its contravening elements, revealing an incidental unstable narrative that is symbolically protesting of the moral of the story to affectionately embrace the political authority of the North Korean party-army regime in the military-first (songun era.

Cooling Simulation and Thermal Abuse Modeling of Lithium-Ion Batteries Using the Newman, Tiedemann, Gu, and Kim (NTGK) Model

DEFF Research Database (Denmark)

Saeed Madani, Seyed; Swierczynski, Maciej Jozef; Kær, Søren Knudsen

2017-01-01

This paper gives insight into the cooling simulation and thermal abuse modeling of lithium-ion batteries by ANSYS FLUENT. Cooling strategies are important issues in the thermal management of lithium-ion battery systems, and it is essential to investigate them attentively in order to maintain...... the functioning temperature of batteries within an optimum range. The high temperature is able not only to decrease the efficiency of batteries but also may lead to the thermal runaway. To comprehend further, the thermal abuse behavior of lithium-ion batteries based on The Newman, Tiedemann, Gu, and Kim (NTGK......) model has been implemented in ANSYS FLUENT software. The results show that to achieve an optimum energy consumption for battery cooling, a minimum value of average heat transfer coefficient can be selected in order to keep the functioning temperature of batteries within an optimum range....

NANOTECHNOLOGY, NANOMEDICINE; ETHICAL ASPECTS.

Science.gov (United States)

Gökçay, Banu; Arda, Berna

2015-01-01

Nanotechnology is a field that we often hear of its name nowadays. Altough what we know about it is soo poor, we admire this field of technlogy, moreover some societies even argues that nanotechnology will cause second endustrial revolution. In addition, nanotechnology makes our basic scientific knowledge upside down and is soo powerfull that it is potent in nearly every scientific field. Thereby, it is imposible to say that nanotechnology; which is soo effective on human and human life; will not cause social and ethical outcomes. In general, the definition of nanotechnology is the reconfiguration of nanomaterials by human; there also are different definitions according to the history of nanotechnology and different point of views. First of all, in comparison to the other tehnology fields, what is the cause of excellence of nanotechnology, what human can do is to foresee the advantages and disadvantages of it, what are the roles of developed and developping countries for the progression of nanotechnology, what is the attitude of nanoethics and what is view of global politics to nanotechological research according to international regulations are all the focus of interests of this study. Last but not least, our apprehension capacity of nanotechnology, our style of adoption and evaluation of it and the way that how we locate nanotechnology in our lifes and ethical values are the other focus of interests.

NANOTECHNOLOGY, NANOMEDICINE; ETHICAL ASPECTS

OpenAIRE

G?K?AY, Banu; ARDA, Berna

2015-01-01

Nanotechnology is a field that we often hear of its name nowadays. Altough what we know about it is soo poor, we admire this field of technlogy, moreover some societies even argues that nanotechnology will cause second endustrial revolution. In addition, nanotechnology makes our basic scientific knowledge upside down and is soo powerfull that it is potent in nearly every scientific field. Thereby, it is imposible to say that nanotechnology; which is soo effective on human and human life; will...

Immunotoxicity of zinc oxide nanoparticles with different size and electrostatic charge

Directory of Open Access Journals (Sweden)

Kim CS

2014-12-01

Full Text Available Cheol-Su Kim,1,* Hai-Duong Nguyen,1,* Rosa Mistica Ignacio,2 Jae-Hyun Kim,1 Hyeon-Cheol Cho,1 Eun Ho Maeng,3 Yu-Ri Kim,4 Meyoung-Kon Kim,4 Bae-Keun Park,5 Soo-Ki Kim1,5 1Department of Microbiology, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon-do, Republic of Korea; 2Department of Environmental Medical Biology, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon-do, Republic of Korea; 3Healthcare Laboratory, Medical Device Evaluation Team, Korea Testing and Research Institute, Gimpo-si, Gyeonggi-do, Republic of Korea; 4Department of Biochemistry and Molecular Biology, Medical School and College, Korea University, Seoul, Republic of Korea; 5Institute of Lifestyle Medicine, Wonju College of Medicine, Yonsei University, Wonju-si, Gangwon-do, Republic of Korea *These authors contributed equally to this work Abstract: While zinc oxide (ZnO nanoparticles (NPs have been recognized to have promising applications in biomedicine, their immunotoxicity has been inconsistent and even contradictory. To address this issue, we investigated whether ZnO NPs with different size (20 or 100 nm and electrostatic charge (positive or negative would cause immunotoxicity in vitro and in vivo, and explored their underlying molecular mechanism. Using Raw 264.7 cell line, we examined the immunotoxicity mechanism of ZnO NPs as cell viability. We found that in a cell viability assay, ZnO NPs with different size and charge could induce differential cytotoxicity to Raw 264.7 cells. Specifically, the positively charged ZnO NPs exerted higher cytotoxicity than the negatively charged ones. Next, to gauge systemic immunotoxicity, we assessed immune responses of C57BL/6 mice after oral administration of 750 mg/kg/day dose of ZnO NPs for 2 weeks. In parallel, ZnO NPs did not alter the cell-mediated immune response in mice but suppressed innate immunity such as natural killer cell activity. The CD4+/CD8+ ratio, a marker for matured T-cells was slightly

EDITORIAL: Focus on Plasma Medicine

Science.gov (United States)

Morfill, G. E.; Kong, M. G.; Zimmermann, J. L.

2009-11-01

-pressure microwave plasmas in an N2 and O2 gas mixture M K Singh, A Ogino and M Nagatsu Degradation of adhesion molecules of G361 melanoma cells by a non-thermal atmospheric pressure microplasma H J Lee, C H Shon, Y S Kim, S Kim, G C Kim and M G Kong The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air A Helmke, D Hoffmeister, N Mertens, S Emmert, J Schuette and W Vioel Reduction and degradation of amyloid aggregates by a pulsed radio-frequency cold atmospheric plasma jet D L Bayliss, J L Walsh, G Shama, F Iza and M G Kong The effect of low-temperature plasma on bacteria as observed by repeated AFM imaging René Pompl, Ferdinand Jamitzky, Tetsuji Shimizu, Bernd Steffes, Wolfram Bunk, Hans-Ulrich Schmidt, Matthias Georgi, Katrin Ramrath, Wilhelm Stolz, Robert W Stark, Takuya Urayama, Shuitsu Fujii and Gregor Eugen Morfill Removal and sterilization of biofilms and planktonic bacteria by microwave-induced argon plasma at atmospheric pressure Mi Hee Lee, Bong Joo Park, Soo Chang Jin, Dohyun Kim, Inho Han, Jungsung Kim, Soon O Hyun, Kie-Hyung Chung and Jong-Chul Park Cell permeabilization using a non-thermal plasma M Leduc, D Guay, R L Leask and S Coulombe Physical and biological mechanisms of direct plasma interaction with living tissue Danil Dobrynin, Gregory Fridman, Gary Friedman and Alexander Fridman Nosocomial infections-a new approach towards preventive medicine using plasmas G E Morfill, T Shimizu, B Steffes and H-U Schmidt Generation and transport mechanisms of chemical species by a post-discharge flow for inactivation of bacteria Takehiko Sato, Shiroh Ochiai and Takuya Urayama Low pressure plasma discharges for the sterilization and decontamination of surfaces F Rossi, O Kylián, H Rauscher, M Hasiwa and D Gilliland Contribution of a portable air plasma torch to rapid blood coagulation as a method of preventing bleeding S P Kuo, O Tarasenko, J Chang, S Popovic, C Y Chen, H W Fan, A Scott, M Lahiani, P Alusta, J D Drake and M Nikolic A two

Uudised

Index Scriptorium Estoniae

2007-01-01

Kalev Saare näitus "Portfolio" Võru Linnagaleriis kuni 2. III. Arhitektuurinäitused "Praha kubism" ja Jozhe Plechnik" Eesti Arhitektuurimuuseumis 03.-04. 2007. Tallinnas Soo 4 avatud kunsti- ja sisustusgaleriist SooSoo (galeristid Kadi Kõpper, Ülle Jehe), kus avanäitusena on kuni 17. III väljas Martin Pedaniku graafikaseeria "Kizoo". Hando Tamme maalinäitus "Meie aja kangelased vol 2" Jõhvi Kunstikooli galeriis 5.-31. III. Kunstiteaduste Instituudi Talvefoorum 007 ja muusikaürituste sari Müsteerium 3.-4. III Juurus. Loetletud "Kujundite taaskasutusel" esinejaid

Optimized formulation of solid self-microemulsifying sirolimus delivery systems

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Cho W

2013-04-01

Full Text Available Wonkyung Cho,1,2 Min-Soo Kim,3 Jeong-Soo Kim,2 Junsung Park,1,2 Hee Jun Park,1,2 Kwang-Ho Cha,1,2 Jeong-Sook Park,2 Sung-Joo Hwang1,4 1Yonsei Institute of Pharmaceutical Sciences, Yonsei University, Incheon, Republic of Korea; 2College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea; 3Department of Pharmaceutical Engineering, Inje University, Gimhae, Republic of Korea; 4College of Pharmacy, Yonsei University, Incheon, Republic of Korea Background: The aim of this study was to develop an optimized solid self-microemulsifying drug delivery system (SMEDDS formulation for sirolimus to enhance its solubility, stability, and bioavailability. Methods: Excipients used for enhancing the solubility and stability of sirolimus were screened. A phase-separation test, visual observation for emulsifying efficiency, and droplet size analysis were performed. Ternary phase diagrams were constructed to optimize the liquid SMEDDS formulation. The selected liquid SMEDDS formulations were prepared into solid form. The dissolution profiles and pharmacokinetic profiles in rats were analyzed. Results: In the results of the oil and cosolvent screening studies, Capryol™ Propylene glycol monocaprylate (PGMC and glycofurol exhibited the highest solubility of all oils and cosolvents, respectively. In the surfactant screening test, D-α-tocopheryl polyethylene glycol 1000 succinate (vitamin E TPGS was determined to be the most effective stabilizer of sirolimus in pH 1.2 simulated gastric fluids. The optimal formulation determined by the construction of ternary phase diagrams was the T32 (Capryol™ PGMC:glycofurol:vitamin E TPGS = 30:30:40 weight ratio formulation with a mean droplet size of 108.2 ± 11.4 nm. The solid SMEDDS formulations were prepared with Sucroester 15 and mannitol. The droplet size of the reconstituted solid SMEDDS showed no significant difference compared with the liquid SMEDDS. In the dissolution study, the release amounts of

„Ritualno” i „struktuirano” odbacivanje u arheološkim interpretacijama: primer sistema za vodosnabdevanje na lokalitetu „Kale” u Krševici

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Ivan Vranić

2016-11-01

Full Text Available Pitanja vezana za rituale, kultove, religiju ili magiju predstavljaju važne ali u značajnoj meri zanemarene i teorijski nedovoljno precizno utemeljene teme u savremenim arheološkim interpretacijama. Cilj rada jeste da na konkretnim primerima potencijalno ritualnih aktivnosti vezanih za izgradnju i moguće „ritualno ubijanje” sistema za vodosnabdevanje na lokalitetu „Kale” u Krševici pokaže kako ovo zanemarivanje nije samo posledica aktuelnosti i trendova o odabiru istraživačkih tema, već se radi o ozbiljnijem problemu koji pokazuje određene nedostatke savremenih pristupa vezanih za arheologiju identiteta i koncepte struktuiranog ili simboličkog odbacivanja.

Islandi-elamus

Index Scriptorium Estoniae

2008-01-01

Galeriis SooSoo on müügil islandi noorte disainerite tööd: Gudrun Lilja Gunnlaugsdottiri laserlõiketehnoloogias raamaturiiulid "Fairytale", Ingibjörg Hanna Bjarnadottiri riidepuud "Raven", Tinna Gunnarsdottiri kummist laualinikud "Samurai", Katrin Olina riidenagid "Tree" ja portselannõud

Pehkinud palkseintega luksusvilla / Jana Rand

Index Scriptorium Estoniae

Rand, Jana, 1963-

2005-01-01

Pädaste mõisa (omanikud Imre Sooäär ja Martin Breuer) 350-aastase moonakatemaja renoveerimine puhkemajaks. Nõu ümberehitamiseks andis soome disainer Ristomatti Ratia. Sisekujunduse autor Imre Sooäär, tema kommentaarid. 10 värv. ill

Effect of zinc oxide nanoparticles on dams and embryo–fetal development in rats

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Hong J

2014-12-01

Full Text Available Jeong-Sup Hong,1,2 Myeong-Kyu Park,1 Min-Seok Kim,1 Jeong-Hyeon Lim,1 Gil-Jong Park,1 Eun-Ho Maeng,1 Jae-Ho Shin,3 Yu-Ri Kim,4 Meyoung-Kon Kim,4 Jong-Kwon Lee,5 Jin-A Park,2 Jong-Choon Kim,6 Ho-Chul Shin2 1Health Care Research Laboratory, Korea Testing and Research Institute, Gimpo, 2College of Veterinary Medicine, Konkuk University, Seoul, 3Department of Biomedical Laboratory Science, Eulji University, Seongnam-si, 4Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, 5Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, 6College of Veterinary Medicine, Chonnam National University, Gwangju, Korea Abstract: This study investigated the potential adverse effects of zinc oxide nanoparticles (ZnOSM20[-] NPs; negatively charged, 20 nm on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague Dawley rats. ZnOSM20(- NPs were administered to pregnant rats by gavage at 0 mg/kg/day, 100 mg/kg/day, 200 mg/kg/day, and 400 mg/kg/day. All dams were subjected to caesarean section on gestational day 20, and all the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight at 400 mg/kg/day and decreased liver weight, and increased adrenal glands weight at 200 mg/kg/day and 400 mg/kg/day. However, no treatment-related difference in the number of corpora lutea, the number of implantation sites, the implantation rate (%, resorption, dead fetuses, litter size, fetal deaths, fetal and placental weights, and sex ratio were observed between the groups. Morphological examinations of the fetuses demonstrated no significant difference in the incidences of abnormalities between the groups. No significant difference was found in the Zn content of fetal tissue between the control and high-dose groups. These results showed

Barriers to the adoption of energy-saving technologies in the building sector: A survey study of Jing-jin-tang, China

International Nuclear Information System (INIS)

Du, Ping; Zheng, Li-Qun; Xie, Bai-Chen; Mahalingam, Arjun

2014-01-01

The building sector of China currently consumes 20% of the total energy consumption. Studies on barriers to the adoption of building energy-saving technologies are of great significance on implementing policies related to achieving energy-saving goals. This paper studied 15 barriers with the aid of information collected through questionnaires and semi-structured interviews. The respondents were 135 employees working in the Jing-jin-tang area. Based on the results of the factor analysis, the barriers were categorized into five groups: attitudes of stakeholders, policies and regulations, auxiliary resources, profitability, and adaptability of the technologies. Analysis of the entire sample showed that the stakeholders’ reluctance to use was the largest barrier, followed by high initial investment and low profitability. Further analysis showed that the occupation and designation of the respondents and the size of the enterprises that they served influenced their perspectives on the barriers. It was found that architects attributed more importance to the adoption of energy-saving technologies than contractors; barriers confronted by employees of large enterprises and small enterprises were different; managers perceived weaker barriers than frontline employees and were more optimistic about the prospect of building energy-saving technologies. Finally, policy recommendations were proposed based on these in-depth and targeted analyses. - Highlights: • Fifteen barriers to the adoption of energy-saving technologies are discussed. • Surveys are conducted in one of China's most technologically developed area. • The barriers are divided into 5 groups according to the results of factor analysis. • Barriers related to profitability greatly hamper the adoption of the technologies. • Comparative analyses show the background of respondents influence their viewpoints

Kanna hy kô hystoe, Joanie Galant-hulle en

African Journals Online (AJOL)

Owner

Vermeulen (3) beskryf dié agtergrond soos volg: “Kanna hy kô hystoe(1965) wortel, soos. Adam Small se ... ten opsigte van die titelkarakters in Van Wyk Louw se dramas Dias(1952) en Germanicus ...... tesis, U van Witwatersrand, 1984. Olivier ...

Factors that influence the selection of learning opportunities for ...

African Journals Online (AJOL)

Sekere knelpunte het egter opgeduik wat as temas beskryf is, naamlik: Bestuursknelpunte, Onderrigknelpunte. Wat betref ";bestuursknelpunte"; as tema is verskeie kategorieë soos werkslading, verpleegtekorte, en kommunikasie probleme geïdentifiseer. Die tema ";onderrigknelpunte"; het kategorieë soos 'n gebrek aan ...

EFFECTS OF MYCORRHIZAL FUNGI ON IN-VITRO NITROGEN RESPONSE OF SOME DUTCH INDIGENOUS ORCHID SPECIES

NARCIS (Netherlands)

DIJK, E; ECK, ND

The effect of mycorrhizal infection on the response to mineral nitrogen was studied in Orchis morio L., Dactylorhiza praetermissa (Druce) Soo var. junialis (Vermin.) Sengh., Dactylorhiza majalis (Reichb.) Hunt & Summerh., and Dactylorhiza incarnara (L.) Soo, using two strains of Ceratorhiza sp. and

Urinary Vitamin D Binding Protein and KIM-1 Are Potent New Biomarkers of Major Adverse Renal Events in Patients Undergoing Coronary Angiography.

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Lyubov Chaykovska

Full Text Available Vitamin-D-binding protein (VDBP is a low molecular weight protein that is filtered through the glomerulus as a 25-(OH vitamin D 3/VDBP complex. In the normal kidney VDBP is reabsorbed and catabolized by proximal tubule epithelial cells reducing the urinary excretion to trace amounts. Acute tubular injury is expected to result in urinary VDBP loss. The purpose of our study was to explore the potential role of urinary VDBP as a biomarker of an acute renal damage.We included 314 patients with diabetes mellitus or mild renal impairment undergoing coronary angiography and collected blood and urine before and 24 hours after the CM application. Patients were followed for 90 days for the composite endpoint major adverse renal events (MARE: need for dialysis, doubling of serum creatinine after 90 days, unplanned emergency rehospitalization or death.Increased urine VDBP concentration 24 hours after contrast media exposure was predictive for dialysis need (no dialysis: 113.06 ± 299.61 ng/ml, n = 303; need for dialysis: 613.07 ± 700.45 ng/ml, n = 11, Mean ± SD, p<0.001, death (no death during follow-up: 121.41 ± 324.45 ng/ml, n = 306; death during follow-up: 522.01 ± 521.86 ng/ml, n = 8; Mean ± SD, p<0.003 and MARE (no MARE: 112.08 ± 302.00 ng/ml, n = 298; MARE: 506.16 ± 624.61 ng/ml, n = 16, Mean ± SD, p<0.001 during the follow-up of 90 days after contrast media exposure. Correction of urine VDBP concentrations for creatinine excretion confirmed its predictive value and was consistent with increased levels of urinary Kidney Injury Molecule-1 (KIM-1 and baseline plasma creatinine in patients with above mentioned complications. The impact of urinary VDBP and KIM-1 on MARE was independent of known CIN risk factors such as anemia, preexisting renal failure, preexisting heart failure, and diabetes.Urinary VDBP is a promising novel biomarker of major contrast induced nephropathy-associated events 90 days after contrast media exposure.

Security risks arising from portable storage devices

CSIR Research Space (South Africa)

Molotsi, K

2012-10-01

Full Text Available of the security risks arising from the use of PSDs, and further provides possible security countermeasures to help organisations and users to protect their digital assets. APPROACH Literature review: ? To investigate security risks posed by PSDs... technology in the workplace. International Journal of Electronic Security and Digital Forensics. 3(1): 73?81 [3] Kim, K., Kim, E. & Hong S. (2009). Privacy information protection in portable device. Proceedings of International Conference on Convergence...

Lung function decline rates according to GOLD group in patients with chronic obstructive pulmonary disease

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Kim J

2015-09-01

Full Text Available Joohae Kim,1 Ho Il Yoon,2 Yeon-Mok Oh,3 Seong Yong Lim,4 Ji-Hyun Lee,5 Tae-Hyung Kim,6 Sang Yeub Lee,7 Jin Hwa Lee,8 Sang-Do Lee,3 Chang-Hoon Lee11Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, 3Department of Pulmonary and Critical Care Medicine and Clinical Research Center for Chronic Obstructive Airway Diseases, Asan Medical Center, University of Ulsan College of Medicine, 4Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, 5Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam, 6Division of Pulmonology, Department of Internal Medicine, Hanyang University Guri Hospital, Hanyang University College of Medicine, Guri, 7Division of Respiratory and Critical Care Medicine, Department of Internal Medicine, College of Medicine, Korea University, 8Department of Internal Medicine, Ewha Womans University Mokdong Hospital, College of Medicine, Ewha Womans University, Seoul, Republic of KoreaBackground: Since the Global Initiative for Chronic Obstructive Lung Disease (GOLD groups A-D were introduced, the lung function changes according to group have been evaluated rarely.Objective: We investigated the rate of decline in annual lung function in patients categorized according to the 2014 GOLD guidelines.Methods: Patients with COPD included in the Korean Obstructive Lung Disease (KOLD prospective study, who underwent yearly postbronchodilator spirometry at least three times, were included. The main outcome was the annual decline in postbronchodilator forced expiratory volume in 1 second (FEV1, which was analyzed by

Li et al., Afr J Tradit Complement Altern Med. (2013) 10(5):375-379 ...

African Journals Online (AJOL)

cadewumi

-gang, Zhao Jin-ning, Wang Zhi, Li Jin. (2004). Effects of Total Flavone from Drynaria Fortunei on Bone. Density and IL-6, IL-4 and TNFα Levels in Ovariectomized Rats. Chinese Journal of Basic Medicine in Traditional Chinese Medicine, 01:.

Interplay of agency and ownership: the intentional binding and rubber hand illusion paradigm combined.

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Niclas Braun

Full Text Available The sense of agency (SoA refers to the phenomenal experience of initiating and controlling an action, whereas the sense of ownership (SoO describes the feeling of myness an agent experiences towards his or her own body parts. SoA has been investigated with intentional binding paradigms, and the sense of ownership (SoO with the rubber-hand illusion (RHI. We investigated the relationship between SoA and SoO by incorporating intentional binding into the RHI. Explicit and implicit measures of agency (SoA-questionnaire, intentional binding and ownership (SoO-questionnaire, proprioceptive drift were used. Artificial hand position (congruent/incongruent and mode of agent (self-agent/other-agent were systematically varied. Reported SoO varied mainly with position (higher in congruent conditions, but also with agent (higher in self-agent conditions. Reported SoA was modulated by agent (higher in self-agent conditions, and moderately by position (higher in congruent conditions. Implicit and explicit agency measures were not significantly correlated. Finally, intentional binding tended to be stronger in self-generated than observed voluntary actions. Results provide further evidence for a partial double dissociation between SoA and SoO, empirically distinct agency levels, and moderate intentional binding differences between self-generated and observed voluntary actions.

Interplay of agency and ownership: the intentional binding and rubber hand illusion paradigm combined.

Science.gov (United States)

Braun, Niclas; Thorne, Jeremy D; Hildebrandt, Helmut; Debener, Stefan

2014-01-01

The sense of agency (SoA) refers to the phenomenal experience of initiating and controlling an action, whereas the sense of ownership (SoO) describes the feeling of myness an agent experiences towards his or her own body parts. SoA has been investigated with intentional binding paradigms, and the sense of ownership (SoO) with the rubber-hand illusion (RHI). We investigated the relationship between SoA and SoO by incorporating intentional binding into the RHI. Explicit and implicit measures of agency (SoA-questionnaire, intentional binding) and ownership (SoO-questionnaire, proprioceptive drift) were used. Artificial hand position (congruent/incongruent) and mode of agent (self-agent/other-agent) were systematically varied. Reported SoO varied mainly with position (higher in congruent conditions), but also with agent (higher in self-agent conditions). Reported SoA was modulated by agent (higher in self-agent conditions), and moderately by position (higher in congruent conditions). Implicit and explicit agency measures were not significantly correlated. Finally, intentional binding tended to be stronger in self-generated than observed voluntary actions. Results provide further evidence for a partial double dissociation between SoA and SoO, empirically distinct agency levels, and moderate intentional binding differences between self-generated and observed voluntary actions.

The efficacy and safety of triple inhaled treatment in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis using Bayesian methods

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Kwak MS

2015-11-01

Full Text Available Min-Sun Kwak,1 Eunyoung Kim,2 Eun Jin Jang,3 Hyun Jung Kim,4 Chang-Hoon Lee5 1Department of Internal Medicine, Healthcare Research Institute, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea; 2Department of Statistics, Kyungpook National University, Daegu, Republic of Korea; 3Department of Information Statistics, Andong National University, Andong, Republic of Korea; 4Department of Preventive Medicine, College of Medicine, Korea University, Seoul, Republic of Korea; 5Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea Purpose: Although tiotropium (TIO and inhaled corticosteroid (ICS/long-acting β-agonists are frequently prescribed together, the efficacy of “triple therapy” has not been scientifically demonstrated. We conducted a systematic review and meta-analysis using Bayesian methods to compare triple therapy and TIO monotherapy.Methods: We searched the MEDLINE, EMBASE, and Cochrane Library databases for randomized controlled trials comparing the efficacy and safety of triple therapy and TIO monotherapy in patients with chronic obstructive pulmonary disease (COPD. We conducted a meta-analysis to compare the effectiveness and safety of triple therapy and TIO monotherapy using Bayesian random effects models.Results: Seven trials were included, and the risk of bias in the majority of the studies was acceptable. There were no statistically significant differences in the incidence of death and acute exacerbation of disease in the triple therapy and TIO monotherapy groups. Triple therapy improved the prebronchodilator forced expiratory volume in 1 second (mean difference [MD], 63.68 mL; 95% credible interval [CrI], 45.29–82.73, and patients receiving triple therapy showed more improvement in St George Respiratory Questionnaire scores (MD, -3.11 points; 95% Cr

Disainiöös / Kaija-Luisa Kurik

Index Scriptorium Estoniae

Kurik, Kaija-Luisa

2008-01-01

26.-28. sept. 2008 Tallinnas toimunud festivalist "Arts and Lights" ja disainiööst "Kummardus loovusele!". Anti üle disainiauhinnad Bruno tootedisaini kategoorias Mare Kelpmanile ning disainiprojekti kategoorias Tarmo Luisule. Islandi disaini näitusest Kultuurikatlas ja poola disaini näitusest SooSoo galeriis. Üritusest Pecha Kucha Night

Die huwelik in die eerste-eeuse Mediterreense wêreld (I): Vroue in ...

African Journals Online (AJOL)

p1243322

huwelikstrategie gekoppel aan sekere tydperke in die geskiedenis van Israel en die Jodedom. .... eeuse Mediterreense wêreld soos volg: “Unlike our Western guilt-focused society, the pivotal value of the ... soos volg: “[Honor] is recognized as the 'pivotal value' of the ancient Mediterranean world, and 'love of honor' ...

50 years of monitoring of the ozone layer in the Czech Republic - results and challenges

Science.gov (United States)

Vanicek, Karel; Skrivankova, Pavla; Metelka, Ladislav; Stanek, Martin

2010-05-01

Long-term observations of total ozone (TOZ) and vertical ozone profiles, the basic parameters of the ozone layer, have been performed at the Solar and Ozone Observatory (SOO) Hradec Kralove and at the Aerological Department (AD) Praha of the Czech Hydrometeorological Institute (CHMI) since 1961 and 1992 respectively. The Dobson and Brewer spectrophotometers regularly calibrated towards the international references and electro-chemical ECC ozone sondes are used for the measurements. The observations contribute to the global GAW and NDACC ozone monitoring systems. Up to now analyses of the data give the basic findings given bellow and documented in the presentation. Some of them have important implication to the international ozone monitoring infrastructure, as well. - The decrease of TOZ by about 5-7 % in the winter-spring months towards the pre ozone-hole period have occurred since the mid eighties. This is in good agreement by the magnitude and time with depletion of the ozone layer due to chemical destruction of ozone in the NH mid-latitudes. - Significant depletion 3-5 % of TOZ has been identified also in the summer season since the early nineties. As this can not be attributed to the man-made chemical processes a change in the UT/LS dynamics over Central Europe is the most probable reason. - Aerological measurements taken at AD show that the summer reduction of TOZ very well coincides with a change of UT/LS temperature that persists for about two decades over the Czech territory. Therefore it has a long-term character that can be regarded as a climate shift in UT/LS and need to be further investigated. - 15 years of unique simultaneous Dobson/Brewer observations of TOZ performed at SOO show systematic seasonal deviations between both data sets that exceed instrumental accuracy of measurements. The differences are mostly caused by different wavelengths and their ozone absorption coefficients used by both instruments. As the Brewer observations are being

Diagnosis of prostate cancer via nanotechnological approach

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Kang BJ

2015-10-01

Full Text Available Benedict J Kang,1,2,* Minhong Jeun,1,2,* Gun Hyuk Jang,1,2 Sang Hoon Song,3 In Gab Jeong,3 Choung-Soo Kim,3 Peter C Searson,4 Kwan Hyi Lee1,2 1KIST Biomedical Research Institute, 2Department of Biomedical Engineering, Korea University of Science and Technology (UST, 3Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 4Institute for Nanobiotechnology, Johns Hopkins University, Baltimore, MD, USA *These authors contributed equally to this work Abstract: Prostate cancer is one of the leading causes of cancer-related deaths among the Caucasian adult males in Europe and the USA. Currently available diagnostic strategies for patients with prostate cancer are invasive and unpleasant and have poor accuracy. Many patients have been overly or underly treated resulting in a controversy regarding the reliability of current conventional diagnostic approaches. This review discusses the state-of-the-art research in the development of novel noninvasive prostate cancer diagnostics using nanotechnology coupled with suggested diagnostic strategies for their clinical implication.Keywords: bioassay, nanomaterial, nanodevice, PSA, non-PSA biomarker, bodily fluid

Increased localized delivery of piroxicam by cationic nanoparticles after intra-articular injection

Directory of Open Access Journals (Sweden)

Kim SR

2016-11-01

Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Sang Hyun Kim,1 Ha Ra Cho,2 Han Sol Kim,2 Yong Seok Choi,2 Young Wook Choi,1 Myung Joo Kang2 1Division of Pharmaceutical Sciences, College of Pharmacy, Chung-Ang University, Seoul, 2College of Pharmacy, Dankook University, Cheonan, Chungnam, South Korea Abstract: Piroxicam (PRX, a potent nonsteroidal anti-inflammatory drug, is prescribed to relieve postoperative and/or chronic joint pain. However, its oral administration often results in serious gastrointestinal adverse effects including duodenal ulceration. Thus, a novel cationic nanoparticle (NP was explored to minimize the systemic exposure and increase the retention time of PRX in the joint after intra-articular (IA injection, by forming micrometer-sized electrostatic clusters with endogenous hyaluronic acid (HA in the synovial cavity. PRX-loaded NPs consisting of poly(lactic-co-glycolic acid, Eudragit RL, and polyvinyl alcohol were constructed with the following characteristics: particle size of 220 nm, zeta potential of 11.5 mV in phosphate-buffered saline, and loading amount of 4.0% (w/w of PRX. In optical and hyperspectral observations, the cationic NPs formed more than 50 µm-sized aggregates with HA, which was larger than the intercellular gaps between synoviocytes. In an in vivo pharmacokinetic study in rats, area under the plasma concentration–time curve (AUC0–24 h and maximum plasma concentration (Cmax of PRX after IA injection of the cationic NPs were <70% (P<0.05 and 60% (P<0.05, respectively, compared to those obtained from drug solution. Moreover, the drug concentration in joint tissue 24 h after dosing with the cationic NPs was 3.2-fold (P<0.05 and 1.8-fold (P<0.05 higher than that from drug solution and neutrally charged NPs, respectively. Therefore, we recommend the IA cationic NP therapy as an effective alternative to traditional oral therapy with PRX, as it increases drug retention selectively in the joint. Keywords: piroxicam

Schisandrae fructus enhances myogenic differentiation and inhibits atrophy through protein synthesis in human myotubes

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Kim CH

2016-05-01

Full Text Available Cy Hyun Kim,1,2,* Jin-Hong Shin,1,3,* Sung Jun Hwang,1,2 Yung Hyun Choi,4 Dae-Seong Kim,1,3 Cheol Min Kim2,51Research Institute of Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, 2Center for Anti-Aging Industry, Pusan National University, Busan, 3Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, 4Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan, 5Department of Biomedical Informatics, Pusan National University School of Medicine, Yangsan, Republic of Korea*These authors contributed equally to this work Abstract: Schisandrae fructus (SF has recently been reported to increase skeletal muscle mass and inhibit atrophy in mice. We investigated the effect of SF extract on human myotube differentiation and its acting pathway. Various concentrations (0.1–10 µg/mL of SF extract were applied on human skeletal muscle cells in vitro. Myotube area and fusion index were measured to quantify myotube differentiation. The maximum effect was observed at 0.5 µg/mL of SF extract, enhancing differentiation up to 1.4-fold in fusion index and 1.6-fold in myotube area at 8 days after induction of differentiation compared to control. Phosphorylation of eukaryotic translation initiation factor 4E-binding protein 1 and 70 kDa ribosomal protein S6 kinase, which initiate translation as downstream of mammalian target of rapamycin pathway, was upregulated in early phases of differentiation after SF treatment. SF also attenuated dexamethasone-induced atrophy. In conclusion, we show that SF augments myogenic differentiation and attenuates atrophy by increasing protein synthesis through mammalian target of rapamycin/70 kDa ribosomal protein S6 kinase and eukaryotic translation initiation factor 4E-binding protein 1 signaling pathway in human myotubes. SF can be a useful natural dietary supplement in increasing skeletal muscle mass, especially in the aged

Tase '08 - kui tase siis ikkagi? / Maarin Ektermann

Index Scriptorium Estoniae

Ektermann, Maarin

2008-01-01

Eesti Kunstiakadeemia lõputööde näitustest, mis toimuvad festivali "Tase '08" raames: vabade kunstide teaduskonna magistritööde väljapanekust Kumu Kunstimuuseumis; disainiteaduskonna lõputööde, mis valmisid koostöös IT Kolledzhi üliõpilastega, näitusest "Arukalt" "SooSoo" galeriis

Structure analysis and core community detection of embodied resources networks among regional industries

Science.gov (United States)

He, Xijun; Dong, Yanbo; Wu, Yuying; Wei, Guodan; Xing, Lizhi; Yan, Jia

2017-08-01

To address the double pressure of scarce resources and regional industrial isomorphism, this paper applied the concepts of exergy and embodied resources based on economic input-output (I-O) data. We constructed the embodied resources networks among the regional industries of Beijing-Tianjin-Hebei (also known as Jing-Jin-Ji) in China. We analyzed the rules of embodied resources consumption in the area's industries, identified the core community structures, and studied the characteristics of industrial homogeneity through regional comparisons. The results showed that the dependence on scarce resources of industrial operations in Beijing was less than in Jin-Ji, while the dependence on finance, technology, information, and other service resources in Beijing was higher than in Jin-Ji. The I-O efficiency of embodied resources among industries and the agglomeration of correlation relationships in industries with large embodied resources were higher than in Jin-Ji. The industrial coincidence degree in the ;bridge; industries and in the core community in Jin-Ji was higher than in Jing-Jin and Jing-Ji, which means the industrial homogeneous competition of Jin-Ji was higher, too. This study makes a significant contribution toward promoting the dislocation development of regional industries, accelerating the coordination of resources, and reducing homogeneity competition.

Anthropocene Knowledge Practices in McKenzie Wark’s Molecular Red and Kim Stanley Robinson’s Aurora

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Gib Prettyman

2018-02-01

Full Text Available Through a close reading of McKenzie Wark’s theoretical treatise 'Molecular Red' (2015 and Kim Stanley Robinson’s novel 'Aurora' (2015, this essay examines how Anthropocene knowledge practices challenge our conceptions of human agency in provocative and potentially productive ways. For example, our knowledge of climate science arises through global material infrastructures. As material components of Anthropocene knowledge practices, these infrastructures reveal the material labors and cyborg structures by means of which our knowledge is produced. Wark sees the heterogenous materiality of Anthropocene knowledge practices as evidence for the value of ‘low theories’ based on a ‘labor point of view.’ At the same time, Anthropocene knowledge practices reveal ‘eco-logical’ complexities and fundamental recognitions of the ‘intra-action’ of entangled matter. These complexities produce very estranged views of human agency. Robinson’s novel highlights the eco-logical implications of contemporary knowledge practices by imagining an interstellar ship that must function as a completely artificial ecosystem for a 170-year voyage to another solar system. The significance of knowledge practices and eco-logical complexity is most evident when failures or crises arise, and 'Aurora' tells the story of many such failures. However, I argue that Robinson’s novel and Wark’s ‘low theory’ ultimately function as hopeful accounts of Anthropocene knowledge practices. Among other things, these practices show the material importance of storytelling and point the way toward more complexly realist theories of human agency.

Association between vitamin D receptor polymorphisms and osteoporosis in patients with COPD

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Kim SW

2015-09-01

Full Text Available Sei Won Kim,1 Jong Min Lee,1 Jick Hwan Ha,1 Hyeon Hui Kang,1 Chin Kook Rhee,1 Jin Woo Kim,1 Hwa Sik Moon,1 Ki Hyun Baek,2 Sang Haak Lee1 1Division of Pulmonology, Critical Care and Sleep Medicine, 2Division of Endocrinology and Metabolism, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Background: Patients with COPD are at an increased risk of osteoporosis. Although many studies have addressed the relationship between the vitamin D receptor (VDR polymorphisms and bone health, this relationship has not been fully investigated in patients with COPD. In this study, we investigated the association of VDR polymorphisms with bone mineral density (BMD and other clinical parameters in patients with COPD. Patients and methods: In total, 200 patients with COPD were included in this study. The VDR polymorphisms rs1544410 (A/G-BsmI, rs7975232 (A/C-ApaI, rs731236 (C/T-TaqI, and rs10735810 (C/T-FokI were determined by Sanger sequencing using blood DNA samples. BMD of the lumbar vertebra and the femoral neck was measured by dual-energy X-ray absorptiometry. Other clinical parameters were also evaluated. Haplotype and multivariate analyses were also performed. Results: Sex, body mass index, steroid use, percentage of forced expiratory volume in 1 second (FEV1, alkaline phosphatase, and 25-hydroxyvitamin D significantly influenced the risk of osteoporosis. Patients with osteoporosis were more likely to carry the rs7975232 C allele compared to normal patients with BMD. Haplotypes GCT and GAT were related to osteoporosis. Patients without the haplotype GAT allele showed a significantly lower T-score at the femoral neck and an increased risk of osteoporosis (odds ratio [OR]= 2.78, 95% confidence interval [CI]= 1.20–6.48, P=0.018 compared with carriers in the dominant model. Conclusion: Genetic variations in VDR are significantly associated with osteoporosis among patients with COPD

Dzhässimaal, avalik loomevabadus / Tui Hirv

Index Scriptorium Estoniae

Hirv, Tui, 1984-

2008-01-01

20. aprillil Tallinna Kunstihoones toimunud üritusest Dzhässimaal, kus improviseeris 20.04.2008 Estonian Guitar Octet koosseisus Jaak Sooäär, Paul Daniel, Robert Jürjendal, Tõnis Leemets, Virgo Sillamaa, Mart Soo, Kalle Tikas ja Tarvo Kaspar Toome. Samal ajal maalisid pilte noored kunstnikud Tallinna kunstikoolist, Sally stuudiost ja Pelgulinna kunstigümnaasiumist

Pädaste mõis pakub nii uut kui vana! / Aale Kask

Index Scriptorium Estoniae

Kask, Aale

2008-01-01

Renoveeritud Pädaste mõisa peahoonest (1875). Omanikud Imre Sooäär ja Martin Breuer. Mõisaansambli restaureerimine toimus aastail 1996-2008. Restaureerimisarhitekt Katrin Etverk. Sisearhitektuur: Imre Sooäär, Kärt Kukkur. Restoranisaal kasvab üle talveaiaks. Kärt Kukkuri, Katrin Etverki ja Ülle Grishakovi kommentaarid. Värv. välisvaade, 14 sisevaadet

Pharmacokinetics, pharmacodynamics and safety of CKD-519, a CETP inhibitor, in healthy subjects

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Kim CO

2016-11-01

Full Text Available Choon Ok Kim,1 Eun Sil Oh,2 Chungam Choi,1 Yeonjoo Kim,3 Sera Lee,4 Semi Kim,4 Min Soo Park1,5 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicines and Regulatory Science, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, 3Chong Kun Dang Clinical Research, Chong Kun Dang Pharmaceutical Corp., 4Chong Kun Dang Research Institute, Chong Kun Dang Pharmaceutical Corp., 5Department of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea Abstract: CKD-519 is a selective and potent cholesteryl ester transfer protein (CETP inhibitor being developed for the treatment of dyslipidemia to raise high-density lipoprotein cholesterol. We investigated the safety, tolerability, pharmacokinetics, and pharmacodynamics of single doses of CKD-519 in healthy adult subjects. A randomized, double-blinded, placebo-controlled, single ascending dose study was performed. Eight healthy subjects were enrolled in each CKD-519 dose group (25, 50, 100, 200, or 400 mg and randomized to CKD-519 (n=6 or matching placebo (n=2. CKD-519 reached the maximum plasma concentration (Cmax at 5–6 h post-dose, and had a long terminal half-life ranging between 40–70 h. The area under the plasma concentration–time curve (AUC and Cmax increased with the dose, however, Cmax and AUC normalized by dose decreased with each incremental dose. CETP activity decreased with dose, and the maximum decrease (63%–83% was observed at 6–8 h post-dose. A sigmoid Emax model best described the relationship between CKD-519 plasma concentrations and CETP activity with an EC50 of 17.3 ng/mL. Overall, 11 adverse events (AEs were observed. All AEs were mild or moderate in intensity, and resolved without any complications. There were no clinically significant effects on blood pressure. In conclusion, single doses of CKD-519 up to 400 mg were well tolerated and showed potent

Job burnout and organizational justice among medical interns in Shanghai, People’s Republic of China

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Jin WM

2015-08-01

Full Text Available Wei-Min Jin,1 Ying Zhang,2 Xiao-Ping Wang1 1Department of Neurology, Shanghai General Hospital, 2Department of Neuroscience, Shanghai Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of ChinaBackground: New challenges are occurring in the medical education in Mainland China, and the main risk is the loss of excellent physician candidates. This is due to lack of respect; a large, strong labor force; relatively low remuneration; unstable relationships between patients and doctors; pressures from the public media; and the possible existence of organizational injustice within the hospital. The study reported here looked at one of the in-hospital risks, psychological job burnout and organizational justice, to identify the possible internal cause–effect relationship at the two major general hospitals both affiliated to Shanghai Jiao Tong University School of Medicine.Objective: The aim of the reported study was to analyze the related factors associated with job burnout in Chinese medical interns in Shanghai and to provide some suggestions to better their occupational development.Methods: A total of 135 medical interns were investigated and assessed by the Organizational Justice Scale and the Maslach Burnout Inventory – General Survey.Results: There was a statistically significant negative correlation between organizational justice and job burnout (r=-0.298, P=0.000, suggesting the existence of job burnout among the participant interns. In particular, emotional exhaustion and cynicism were statistically more significant; the comparison between the N group (from Nanjing and S group (Shanghai showed significant difference in participation and reduced professional efficacy (P<0.05, with reduced professional efficacy in N group more significant than in S group, and participation in S group more significant than in N group.Conclusion: Job burnout existed among Chinese medical interns, and was associated

Urologic symptoms and burden of frailty and geriatric conditions in older men: the Aging Study of PyeongChang Rural Area

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Jang IY

2018-02-01

Full Text Available Il-Young Jang,1,2 Chang Ki Lee,3 Hee-Won Jung,4,5 Sang Soo Yu,2 Young Soo Lee,1 Eunju Lee,1 Dae Hyun Kim6,7 1Department of Internal Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea; 2PyeongChang Health Center & County Hospital, PyeongChang, Gangwon-Do, Republic of Korea; 3Goldman Urology Clinic, Seoul, Republic of Korea; 4Graduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology (KAIST, Daejeon, Republic of Korea; 5Geriatric Center, Seoul National University Bundang Hospital, Seongnam, Gyeonggi-Do, Republic of Korea; 6Division of Gerontology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA; 7Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Boston, MA, USA Purpose: Frailty is an important consideration in the management of lower urinary tract symptoms and erectile dysfunction in older men; frailty increases vulnerability to treatment-related adverse outcomes, but its burden is not known. The authors aimed to examine the burden of frailty and associated geriatric conditions in community-dwelling older men.Patients and methods: A cross-sectional study was conducted with 492 community-dwelling older men (mean age, 74.2 years; standard deviation, 5.6 years. All the participants were administered the International Prostate Symptom Score (IPSS (range: 0–35 and a five-item version of the International Index of Erectile Function (IIEF-5 (range: 5–25. Frailty phenotype was assessed based on exhaustion, inactivity, slowness, weakness, and weight loss. Prevalence of frailty phenotype and geriatric conditions were assessed by the IPSS severity category (mild, 0–7; moderate, 8–19; severe, 20–35 points and the first IIEF-5 question, which assesses the confidence in erectile function (low, 1–2; moderate, 3; high, 4–5 points.Results: Older men with severe urologic

Multiobjective Optimization of Linear Cooperative Spectrum Sensing: Pareto Solutions and Refinement.

Science.gov (United States)

Yuan, Wei; You, Xinge; Xu, Jing; Leung, Henry; Zhang, Tianhang; Chen, Chun Lung Philip

2016-01-01

In linear cooperative spectrum sensing, the weights of secondary users and detection threshold should be optimally chosen to minimize missed detection probability and to maximize secondary network throughput. Since these two objectives are not completely compatible, we study this problem from the viewpoint of multiple-objective optimization. We aim to obtain a set of evenly distributed Pareto solutions. To this end, here, we introduce the normal constraint (NC) method to transform the problem into a set of single-objective optimization (SOO) problems. Each SOO problem usually results in a Pareto solution. However, NC does not provide any solution method to these SOO problems, nor any indication on the optimal number of Pareto solutions. Furthermore, NC has no preference over all Pareto solutions, while a designer may be only interested in some of them. In this paper, we employ a stochastic global optimization algorithm to solve the SOO problems, and then propose a simple method to determine the optimal number of Pareto solutions under a computational complexity constraint. In addition, we extend NC to refine the Pareto solutions and select the ones of interest. Finally, we verify the effectiveness and efficiency of the proposed methods through computer simulations.

Search Results | Page 79 | IDRC - International Development ...

International Development Research Centre (IDRC) Digital Library (Canada)

2006-01-01

Results 781 - 790 of 8491 ... Middle East Good Governance Fund (MEGGF) Special Initiatives Division. Published date. January 1, 2006. Studies. -. Report on Chief Kim Baird's trip to Ecuador, May 24 to June 1, 2010. Published date. January 1, 2010. Studies. -. Making agri-food systems work for the rural poor in Eastern and ...

A fixed-dose combination tablet of gemigliptin and metformin sustained release has comparable pharmacodynamic, pharmacokinetic, and tolerability profiles to separate tablets in healthy subjects

Directory of Open Access Journals (Sweden)

Park SI

2015-02-01

Full Text Available Sang-In Park,1,* Howard Lee,1,2,* Jaeseong Oh,1 Kyoung Soo Lim,3 In-Jin Jang,1 Jeong-Ae Kim,4 Jong Hyuk Jung,4 Kyung-Sang Yu1 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, 2Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Clinical Trials Center, Seoul National University Hospital, Seoul, 3Department of Clinical Pharmacology and Therapeutics, CHA University School of Medicine and CHA Bundang Medical Center, Seongnam, 4LG Life Sciences, Ltd, Seoul, Republic of Korea *These authors contributed equally to this work Background: In type 2 diabetes mellitus, fixed-dose combination (FDC can provide the complementary benefits of correction of multiple pathophysiologic defects such as dysfunctions in glycemic or metabolic control while improving compliance compared with separate tablets taken together. The objective of the study reported here was to compare the pharmacodynamic (PD, pharmacokinetic (PK, and tolerability profiles of gemigliptin and extended-release metformin (metformin XR between FDC and separate tablets.Methods: A randomized, open-label, single-dose, two-way, two-period, crossover study was conducted in 28 healthy male volunteers. Two FDC tablets of gemigliptin/metformin 25/500 mg or separate tablets of gemigliptin (50 mg ×1 and metformin XR (500 mg ×2 were orally administered in each period. Serial blood samples were collected up to 48 hours post-dose to determine dipeptidyl peptidase 4 (DPP-4 activity using spectrophotometric assay and concentrations of gemigliptin and metformin using tandem mass spectrometry. Geometric mean ratios (GMRs of FDC to separate tablet formulations and their 90% confidence intervals (CIs were calculated to compare the PD and PK parameters between the two formulations. Tolerability was assessed throughout the study.Results: The plasma DPP-4 activity�

International Journal of Biological and Chemical Sciences - Vol 11 ...

African Journals Online (AJOL)

... L. 1758: Hymenoptera, Apidae) in three beekeeping sites of the Democratic Republic of Congo · EMAIL FREE FULL TEXT EMAIL FREE FULL TEXT DOWNLOAD FULL TEXT DOWNLOAD FULL TEXT. Boniface Posho Ndola, Paul Malumba, Bernard Wathelet, Eric Haubruge, Frederic Francis, Bach Kim Nguyen, 541-555.

Improvement in the amine glass platform by bubbling method for a DNA microarray

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Jee SH

2015-10-01

Full Text Available Seung Hyun Jee,1 Jong Won Kim,2 Ji Hyeong Lee,2 Young Soo Yoon11Department of Chemical and Biological Engineering, Gachon University, Seongnam, Gyeonggi, Republic of Korea; 2Genomics Clinical Research Institute, LabGenomics Co., Ltd., Bundang-gu, Seongnam-si, Gyeonggi-do, Republic of KoreaAbstract: A glass platform with high sensitivity for sexually transmitted diseases microarray is described here. An amino-silane-based self-assembled monolayer was coated on the surface of a glass platform using a novel bubbling method. The optimized surface of the glass platform had highly uniform surface modifications using this method, as well as improved hybridization properties with capture probes in the DNA microarray. On the basis of these results, the improved glass platform serves as a highly reliable and optimal material for the DNA microarray. Moreover, in this study, we demonstrated that our glass platform, manufactured by utilizing the bubbling method, had higher uniformity, shorter processing time, lower background signal, and higher spot signal than the platforms manufactured by the general dipping method. The DNA microarray manufactured with a glass platform prepared using bubbling method can be used as a clinical diagnostic tool. Keywords: DNA microarray, glass platform, bubbling method, self-assambled monolayer

Joint Institute for Nanoscience Annual Report 2004

Energy Technology Data Exchange (ETDEWEB)

Baer, Donald R.; Campbell, Charles

2005-02-01

Due to the inherently interdisciplinary nature of nanoscience and nanotechnology, research in this arena is often significantly enhanced through creative cooperative activities. The Joint Institute for Nanoscience (JIN) is a venture of the University of Washington (UW) and Pacific Northwest National Laboratory (PNNL) to encourage and enhance high impact and high quality nanoscience and nanotechnology research that leverages the strengths and capabilities of both institutions, and to facilitate education in these areas. This report summarizes JIN award activities that took place during fiscal year 2004 and provides a historical list of JIN awardees, their resulting publications, and JIN-related meetings. Major portions of the JIN efforts and resources are dedicated to funding graduate students and postdoctoral research associates to perform research in collaborations jointly directed by PNNL staff scientists and UW professors. JIN fellowships are awarded on the basis of applications that include research proposals. They have been very successful in expanding collaborations between PNNL and UW, which have led to many excellent joint publications and presentations and enhanced the competitiveness of both institutions for external grant funding. JIN-based interactions are playing a significant role in creating new research directions and reshaping existing research programs at both the UW and PNNL. The JIN also co-sponsors workshops on Nanoscale Science and Technology, four of which have been held in Seattle and one in Richland. In addition to involving PNNL staff in various UW nanoscience courses and seminars, a National Science Foundation grant, Development of UW-PNL Collaborative Curriculums in Nano-Science and Technology, has allowed the development of three intensive short courses that are taught by UW faculty, PNNL staff, and faculty from other institutions, including Washington State University, the University of Idaho, Stanford University, and the University of

Pressure-induced Formation of Energetic and Structural Extended Solids with Quench-recovery to Ambient Conditions

Science.gov (United States)

2014-06-12

Duck Young Kim. Synthesis of Mg2C: A Magnesium Methanide, Angewandte Chemie International Edition, (08 2013): 0. doi: 10.1002/anie.201303463 TOTAL...Polymorph of2 Magnesium Sesquicarbide, Inorganic Chemistry (02 2014) DuckYoung Kim, Stevce Stefanoski, Oleksandr O. Kurakevych, Timothy A. Strobel...new phase was discovered in the Li+C system. Figure 6 shows x‐ray diffraction and Raman spectra obtained from this phase, which cannot be

Economic Growth and Sustainable Housing: An Uneasy Relationship

DEFF Research Database (Denmark)

Buch-Hansen, Hubert

2017-01-01

Book review of: "Economic Growth and Sustainable Housing: An Uneasy Relationship" by Jin Xue (Routledge, 2014)......Book review of: "Economic Growth and Sustainable Housing: An Uneasy Relationship" by Jin Xue (Routledge, 2014)...

Concept development of "compassion fatigue" in clinical nurses: Application of Schwartz-Barcott and Kim's hybrid model

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Mahdieh Sabery

2017-06-01

Full Text Available Compassion fatigue is not a new concept in nursing; yet, it is not well known and there is no fixed clear definition of the term. The ambiguity surrounding how to define compassion fatigue has challenged its measurement and evaluation. Thus, any attempt to determine attributes of this underdeveloped concept and studying it in a new socio-cultural context requires concept development. The purpose of this study is to clarify the concept of compassion fatigue through concept development and to produce a vivid and tentative definition of this concept in clinical practice. Concept development was conducted using a three-step hybrid concept analysis including theoretical, fieldwork, and final analysis phases according to Schwartz-Barcott and Kim's method. We reviewed and analyzed 48 articles that met the inclusion criteria. Following, the first author conducted 13 interviews with clinical nurses followed by an inductive content analysis. Finally, a comprehensive definition of compassion fatigue in nurses was attained. Compassion fatigue in nurses can be explained as a cumulative and progressive process of absorption of the patient’s pain and suffering formed from the sympathetic and caring interactions with the patients and their families. The physical, emotional, intellectual, spiritual, social, and organizational consequences of compassion fatigue are so extensive that they threaten the existential integrity of the nurse. Context-based variables (culture, family, and community such as personality features like devotion behaviors and commitment towards the patient, exposure to multiple stressors, organizational challenges, and lack of self-care are factors associated with an increased risk of compassion fatigue. Concept development of compassion fatigue is the first step in the protection of nurses against the destructive consequences of compassion fatigue and to improve quality of care.

Isolation of reovirus T3D mutants capable of infecting human tumor cells independent of junction adhesion molecule-A.

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Diana J M van den Wollenberg

Full Text Available Mammalian Reovirus is a double-stranded RNA virus with a distinctive preference to replicate in and lyse transformed cells. On that account, Reovirus type 3 Dearing (T3D is clinically evaluated as oncolytic agent. The therapeutic efficacy of this approach depends in part on the accessibility of the reovirus receptor Junction Adhesion Molecule-A (JAM-A on the target cells. Here, we describe the isolation and characterization of reovirus T3D mutants that can infect human tumor cells independent of JAM-A. The JAM-A-independent (jin mutants were isolated on human U118MG glioblastoma cells, which do not express JAM-A. All jin mutants harbour mutations in the S1 segments close to the region that encodes the sialic acid-binding pocket in the shaft of the spike protein. In addition, two of the jin mutants encode spike proteins with a Q336R substitution in their head domain. The jin mutants can productively infect a wide range of cell lines that resist wt reovirus T3D infection, including chicken LMH cells, hamster CHO cells, murine endothelioma cells, human U2OS and STA-ET2.1 cells, but not primary human fibroblasts. The jin-mutants rely on the presence of sialic-acid residues on the cell surface for productive infection, as is evident from wheat germ agglutinin (WGA inhibition experiments, and from the jin-reovirus resistance of CHO-Lec2 cells, which have a deficiency of sialic-acids on their glycoproteins. The jin mutants may be useful as oncolytic agents for use in tumors in which JAM-A is absent or inaccessible.

The Effects of the Hominis Placenta Herbal acupuncture on Sleep pattern disturbance

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Youn Hyoun-min

2005-02-01

Full Text Available Objective : This study has been designed and performed to identify the effects of Hominis Placenta herbal acupuncture which is usually used in reducing sleep pattern disturbances. Methods : The study subjects studied included 48 patients who were admitted in hospital located in Pusan, and they were classified into 2 groups : 25 patients in the experimental group who injected Hominis Placenta herbal acupuncture and 23 patients in the control group who were treated by acupuncture. The both group injected on GB20, GB12 and HT7 for 5 days without medicine. The sleep pattern disturbance score was measured by using 15 questions according to Korean Sleep Scale A(Oh, Jin Joo. Song, Mi Soon. Kim, Shin Mi. 1998. Results & conclusions : The sleep pattern disturbance score of the experimental group who injected Hominis Placenta herbal acupuncture was significantly lower than that of the control group. (t= 7.00 p= .00 These results provided that Hominis Placenta herbal acupuncture of GB20, GB12 and HT7 was effective for relieving sleep pattern disturbances, it is need more sample's number and more treatmentt's duration.

Organization of research team for nano-associated safety assessment in effort to study nanotoxicology of zinc oxide and silica nanoparticles

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Kim YR

2014-12-01

Full Text Available Yu-Ri Kim,1,* Sung Ha Park,2,* Jong-Kwon Lee,3 Jayoung Jeong,3 Ja Hei Kim,4 Eun-Ho Meang,5 Tae Hyun Yoon,6 Seok Tae Lim,7 Jae-Min Oh,8 Seong Soo A An,9 Meyoung-Kon Kim1 1Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 2Department of Biochemistry, University of Bath, Bath, UK; 3Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungchungbuk-do, 4Consumers Korea, Chongro-ku, 5General toxicology team, Korea Testing and Research Institute, 6Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, College of Natural Sciences, Hanyang University, Seoul, 7Department of Nuclear Medicine, Chonbuk National University Medical School, Jeonju, Jellabuk-Do, 8Department of Chemistry and Medical Chemistry, College of Science and Technology, Yonsei University, Gangwon-do, 9Department of Bionanotechnology, Gachon Medical Research Institute, Gachon University, Seongnam, South Korea *Authors contributed equally to this work Abstract: Currently, products made with nanomaterials are used widely, especially in biology, biotechnologies, and medical areas. However, limited investigations on potential toxicities of nanomaterials are available. Hence, diverse and systemic toxicological data with new methods for nanomaterials are needed. In order to investigate the nanotoxicology of nanoparticles (NPs, the Research Team for Nano-Associated Safety Assessment (RT-NASA was organized in three parts and launched. Each part focused on different contents of research directions: investigators in part I were responsible for the efficient management and international cooperation on nano-safety studies; investigators in part II performed the toxicity evaluations on target organs such as assessment of genotoxicity, immunotoxicity, or skin penetration; and investigators in part III evaluated the toxicokinetics of NPs with newly developed

Hâkim Tasarım ve Ekşi Sözlük: İnternet’in Dönüşümünü Anlamak

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Babacan Taşdemir

2014-02-01

Full Text Available Son yıllarda bir yanda devletler, diğer yanda sermaye kuruluşları, siyasi, idari ve ticari amaçları ile İnternet ortamını gittikçe daha fazla kolonileştirmektedirler. Bu da siyasi ve ticari baskılardan azade bir özgürlük alanı olarak görülen İnternet’e ilişkin toplumsal beklentilere zıt bir durum ortaya çıkarmaktadır. Çalışmamız, İnternet’teki bu dönüşümü üretim gücü ve üretim ilişkileri kavramları üzerinden eleştirel bir gözle değerlendirmeyi önermektedir. Dönüşüm, ‘Teknolojik Değişimin Döngüsel Modeli’ndeki ‘mayalanma dönemi’ ve ‘hâkim tasarım’ kavramlarının sunduğu potansiyelden faydalanılarak açıklanmaya çalışılmaktadır.  Burada ‘mayalanma dönemi’ ile İnternette ifade özgürlüğü açısından daha uygun olan ilk dönemlere, ‘hâkim tasarım’ ile ise yerleşik üretim ve iktidar ilişkilerinin daha fazla nüfuz ettiği yakın döneme gönderme yapılmaktadır. Ekşi Sözlük örneği ile de savlarını destekleyen çalışmamız, üç kategori üzerinden örnek olaylarla Sözlük’ün dönüşümünü değerlendirmektedir: İş çevreleriyle ticari ilişkilere bağlı dönüşüm, İnternet’in düzenlenmesine dair hukuki çerçeve ve kamu otoriteleri ile ilişkilere bağlı olarak geçirilen dönüşüm, Sözlük kullanıcıları ve sahipleri arasındaki örgütsel ilişkinin değişimi dolayımında geçirilen dönüşüm. Sonuç olarak, İnternet’in ‘mayalanma döneminde’, yani görece serbest bir ortamda, Ekşi Sözlük popülaritesini ve saygınlığını, yaratıcı ve muhalif duruş ile karakterize olan bir ifade alanı olarak kazansa da, zaman içinde tamamen kâr merkezli bir işletmeye dönüşmektedir. Böylece bir yandan pazarlama stratejilerinin ana mecralarından biri diğer yandan da politik baskıya tabii sıradan bir forum ve paylaşım sitesi haline gelmektedir. Sözlük’ün gelişimine ilişkin örnek olaylar ele

The Impacts of Different PBL Schemes on the Simulation of PM2.5 during Severe Haze Episodes in the Jing-Jin-Ji Region and Its Surroundings in China

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Tian Li

2016-01-01

Full Text Available In this study, three schemes [Yonsei University (YSU, Mellor-Yamada-Janjic (MYJ, and Bougeault-Lacarrère (Boulac] were employed in the Weather Research and Forecasting/Chemistry (WRF-Chem model to simulate the severe haze that occurred in February 2014 in the Jing-Jin-Ji region and its surroundings. The PM2.5 concentration simulated using the three schemes, together with the meteorological factors closely related to PM2.5 (wind speed, local vertical diffusivity, and PBL height, was evaluated through comparison with observations. The results indicated that the eastern plain cities produced better simulation results than the western cities, and the cities under the eastern root of Taihang Mountain produced the worst results in simulating high PM2.5 concentration in haze. All three schemes simulated very similar variation trends of the surface PM2.5 concentration compared with observations. The diurnal variations of simulated surface PM2.5 were not as reasonable as their reflection of daily averaged variation. The simulated concentrations of surface PM2.5 using the YSU, MYJ, and Boulac schemes all showed large negative errors during daytime in polluted days due to their inefficient descriptions of local atmospheric stability or diffusion processes in haze. The lower ability of PBL schemes in distinguishing the diffusion between haze and clean days in the complex topography areas in China is an important problem for PM2.5 forecasting, which is worthy of being studied in detail.

JPRS Report, China, Maos Legacy in Anhui, Rural Reform 1978-80.

Science.gov (United States)

1989-07-28

boil some noodles , and then asked Zhan Shaozhou: "What brought you here?" "To report to you!" "Report what?" "It has begun. More is being done...policy of looking after serious disaster areas on holidays, providing each person with 3 jin of rice, 2 jin of noodles , and xh jin of meat. They went...abandon for an instant ! Chapter 6. A Tragedy Not To Be Repeated—1980: The Great Anhui Flood History Continues To Testify 1 The Earth, which nurtures us

Určení hodnoty věcných břemen stavby na cizím pozemku a přechodu nebo přejezdu přes pozemek jiného vlastníka

OpenAIRE

Kuhrová, Kristýna

2011-01-01

Diplomová práce je zaměřena na problematiku věcných břemen z hlediska činnosti znalce. V první části práce je proveden rozbor platné právní úpravy věcných břemen, jejich členění, příčiny možného vzniku, změn a zániku. Dále následuje obecný popis metodiky oceňování věcných břemen, vymezení jednotlivých druhů cen a účelů oceňování věcných břemen. V návrhové části je teoretický rozbor aplikován na dva konkrétní případy věcných břemen, a to věcného břemene přechodu přes pozemek jiného vlastníka a...

Docetaxel-loaded multilayer nanoparticles with nanodroplets for cancer therapy

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Oh KS

2016-03-01

Full Text Available Keun Sang Oh,1,* Kyungim Kim,1,* Byeong Deok Yoon,1 Hye Jin Lee,1 Dal Yong Park,1 Eun-yeong Kim,1 Kiho Lee,1 Jae Hong Seo,2 Soon Hong Yuk1,2 1College of Pharmacy, Korea University, Sejong, 2Biomedical Research Center, Korea University Guro Hospital, Guro-gu, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: A mixture of docetaxel (DTX and Solutol® HS 15 (Solutol transiently formed nanodroplets when it was suspended in an aqueous medium. However, nanodroplets that comprised DTX and Solutol showed a rapid precipitation of DTX because of their unstable characteristics in the aqueous medium. The incorporation of nanodroplets that comprised DTX and Solutol through vesicle fusion and subsequent stabilization was designed to prepare multilayer nanoparticles (NPs with a DTX-loaded Solutol nanodroplet (as template NPs core for an efficient delivery of DTX as a chemotherapeutic drug. As a result, the DTX-loaded Solutol nanodroplets (~11.7 nm were observed to have an increased average diameter (from 11.7 nm to 156.1 nm and a good stability of the hydrated NPs without precipitation of DTX by vesicle fusion and multilayered structure, respectively. Also, a long circulation of the multilayer NPs was observed, and this was due to the presence of Pluronic F-68 on the surface of the multilayer NPs. This led to an improved antitumor efficacy based on the enhanced permeation and retention effect. Therefore, this study indicated that the multilayer NPs have a considerable potential as a drug delivery system with an enhanced therapeutic efficacy by blood circulation and with low side effects. Keywords: multilayer nanoparticles, Solutol, Pluronic F-68, docetaxel, cancer therapy

Analysis of the coexisting pathways for NO and N2O formation in Chernozem using the (15)N-tracer SimKIM-Advanced model.

Science.gov (United States)

Stange, Claus Florian; Spott, Oliver; Russow, Rolf

2013-01-01

The nitrogen (N) cycle consists of a variety of microbial processes. These processes often occur simultaneously in soils, but respond differently to local environmental conditions due to process-specific biochemical restrictions (e.g. oxygen levels). Hence, soil nitrogen cycling (e.g. soil N gas production through nitrification and denitrification) is individually affected through these processes, resulting in the complex and highly dynamic behaviour of total soil N turnover. The development and application of methods that facilitate the quantification of individual contributions of coexisting processes is a fundamental prerequisite for (i) understanding the dynamics of soil N turnover and (ii) implementing these processes in ecosystem models. To explain the unexpected results of the triplet tracer experiment (TTE) of Russow et al. (Role of nitrite and nitric oxide in the processes of nitrification and denitrification in soil: results from (15)N tracer experiments. Soil Biol Biochem. 2009;41:785-795) the existing SimKIM model was extended to the SimKIM-Advanced model through the addition of three separate nitrite subpools associated with ammonia oxidation, oxidation of organic nitrogen (Norg), and denitrification, respectively. For the TTE, individual treatments with (15)N ammonium, (15)N nitrate, and (15)N nitrite were conducted under oxic, hypoxic, and anoxic conditions, respectively, to clarify the role of nitric oxide as a denitrification intermediate during N2O formation. Using a split nitrite pool, this analysis model explains the observed differences in the (15)N enrichments in nitric oxide (NO) and nitrous oxide (N2O) which occurred in dependence on different oxygen concentrations. The change from oxic over hypoxic to anoxic conditions only marginally increased the NO and N2O release rates (1.3-fold). The analysis using the model revealed that, under oxic and hypoxic conditions, Norg-based N2O production was the dominant pathway, contributing to 90 and 50�

Kim Magrini | NREL

Science.gov (United States)

System Control software Education Ph.D., Physical Chemistry, University of Colorado at Boulder, 1984-1989 But Converges During Decomposition-Transformation," Soil Biology and Biochemistry (2013) " Catalytic Conditioning of Biomass-Derived Syngas," Topics in Catalysis (2012) "Transformation of

Passacaglia van J.S. Bach en Das Passagen-Werk van Walter Benjamin - literêre montage as mosaïekwerk in Memorandum. 'n Verhaal met skilderye (2006)

OpenAIRE

van Vuuren, Helize

2014-01-01

Van Niekerk se Memorandum-narratief is 'n gedenkskrif vir die elegies-realistiese skilder, Adriaan van Zyl, wat in September 2006 sterf - soos Walter Benjamin in sy laat veertigs en insgelyks met sy kunstenaarsloopbaan onderbreek. Van Niekerk stel in Memorandum vir haarself 'n uitdagende taak (soos Wiid dit formuleer aan die begin van "Memorandum 3"): om Bach se Passacaglia en fuga in C Mineur (BWV 582) (± 1715) te "vertaal" in prosa en om 'n kleiner, Afrikaanse weergawe van Benjamin se Das P...

A STUDY OF METABOLIC SYNDROME IN PATIENTS UNDERGOING CORONARY ANGIOGRAPHY AT KIMS HOSPITAL, HUBBALLI, KARNATAKA, INDIA

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Chandrashekar K

2018-01-01

Full Text Available BACKGROUND Coronary heart disease has become an epidemic since 20th century. Deaths due to the same are increasing of around 17.5 million deaths in year 2012. The deaths are increasing more in developing countries and metabolic syndrome is a cluster of disorders, which are promoting the development of coronary artery diseases. The disorders include central obesity, insulin resistance, dyslipidaemia and hypertension. Increasing prevalence, changing lifestyle and progression of the disease without obvious symptoms had led to increasing morbidity and mortality. The non-infectious epidemic of the century is posing great challenges to healthcare and research in development of more infrastructure and funds to prevent and treat the disease. MATERIALS AND METHODS A total of 100 patients diagnosed with CAD and posted for Coronary Angiogram (CAG in ICCU at KIMS Hospital, Hubballi, were studied over a period of one and a half year. Cases were categorised according to ATPIII and new IDF criteria for metabolic syndrome and compared. Clinical evaluation, ECG, lipid profile and 2D-echo was done. Statistical analysis done using unpaired t-test, Mann-Whitney tests, Chi-square test and Kappa statistics. RESULTS Of the total 100, 57 had metabolic syndrome by either ATP criteria or IDF criteria. Kappa=0.859 (p-value 150 mg/dL and DM or FBS >100 mg/dL (p value <0.001. The mean values of SBP (144.0 vs. 120.8, DBP (85.6 vs. 73.8 and waist circumference (95.4 vs. 87.7 was statistically significant (p value <0.01 between patients with metabolic syndrome and without metabolic syndrome with IDF criteria (p value <0.001. It was observed LAD (28.1% was the most common vessel involved individually. There was no much significance related to metabolic syndrome. Incidence of CAD was more common in patients with metabolic syndrome than other group. CONCLUSION The prevalence of metabolic syndrome was high in patients with CAD. Both metabolic syndrome definitions identify subset

El individuo en el cambio: la transformación de las relaciones bilaterales entre la República de Corea y la República Popular Democrática de Corea, bajo la figura del presidente surcoreano Kim Dae-Jung

OpenAIRE

Perilla Moreno, Jairo Andrés

2017-01-01

Este artículo busca interpretar el proceso mediante el cual las ideas y presupuestos políticos y sociales del expresidente surcoreano Kim Dae-Jung, permitieron una transformación significativa de las relaciones bilaterales entre Corea del Sur y Corea del Norte, durante su periodo presidencial entre los años 1998 y 2003. Inicialmente, dichas relaciones estuvieron caracterizadas por una incesante tensión militar como resultado de la Guerra de Corea, escenario dentro del cual apareció la figura ...

Association of incidental emphysema with annual lung function decline and future development of airflow limitation

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Koo HK

2016-01-01

Full Text Available Hyeon-Kyoung Koo,1 Kwang Nam Jin,2 Deog Kyeom Kim,3 Hee Soon Chung,3 Chang-Hoon Lee3,4 1Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, College of Medicine, Ilsan Paik Hospital, Inje University, Goyang-si, Gyeonggi-Do, 2Department of Radiology, Seoul Metropolitan Government – Seoul National University Boramae Medical Center, 3Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, 4Department of Internal Medicine, Division of Pulmonary and Critical Care Medicine, Seoul National University College of Medicine, Seoul National University Hospital, Seoul, Republic of Korea Objectives: Emphysema is one of the prognostic factors for rapid lung function decline in patients with COPD, but the impact of incidentally detected emphysema on population without spirometric abnormalities has not been evaluated. This study aimed to determine whether emphysema detected upon computed tomography (CT screening would accelerate the rate of lung function decline and influence the possibility of future development of airflow limitation in a population without spirometric abnormalities.Materials and methods: Subjects who participated in a routine screening for health checkup and follow-up pulmonary function tests for at least 3 years between 2004 and 2010 were retrospectively enrolled. The percentage of low-attenuation area below −950 Hounsfield units (%LAA−950 was calculated automatically. A calculated value of %LAA−950 that exceeded 10% was defined as emphysema. Adjusted annual lung function decline was analyzed using random-slope, random-intercept mixed linear regression models.Results: A total of 628 healthy subjects within the normal range of spriometric values were included. Multivariable analysis showed that the emphysema group exhibited a faster decline in forced vital capacity (−33.9 versus −18.8�

Scenario Planning Analysis for Startup Business Case Study: Kemilau Indonesia Magazine

OpenAIRE

Mulyanto, Frieta Miasari; Sunitiyoso, Yos

2013-01-01

This research explained about the application of scenario planning analysis as solution for Kemilau Indonesia Magazine (KIM) which was born from the opportunities as information and promotion media of tourism. As a new player, KIM has several internal and external issues that impact on its survival. The technique used in this method is to collect data and information to be analyzed in order to generate predictions as a preparation for decision making process. This method give an overview of e...

"Glimpses of the Duanwu Festival" by Fang Xun (1736-1799) : commemorative painting or private souvenir ?

OpenAIRE

Kerlan-Stephens , Anne

2001-01-01

International audience; Fang Xun (1736 or 1737-1799) was a painter from the Hangzhou area who is now known essentially as the author of a treatise on painting, although he enjoyed during his lifetime local artistic fame. This paper details his relationship with a network of friends and clients belonging to the local gentry through the analysis of a painting he realized around 1780, describing a gathering at the estate of his main patron, Jin Deyu (1750-1800).

77 FR 63872 - Senior Executive Service; Appointment of Members to the Performance Review Board

Science.gov (United States)

2012-10-17

... Resources--Kim L.H. Green. Rotating Membership ASP Kathleen E. Franks, Director, Office of Regulatory and... OLMS Stephen J. Willertz, Director, Office of Enforcement and International Union Audits--appointment...

Limit loads for piping branch junctions under internal pressure and in-plane bending-Extended solutions

International Nuclear Information System (INIS)

Kim, Yun-Jae; Lee, Kuk-Hee; Park, Chi-Yong

2008-01-01

The authors have previously proposed plastic limit load solutions for thin-walled branch junctions under internal pressure and in-plane bending, based on finite element (FE) limit loads resulting from three-dimensional (3-D) FE limit analyses using elastic-perfectly plastic materials [Kim YJ, Lee KH, Park CY. Limit loads for thin-walled piping branch junctions under internal pressure and in-plane bending. Int J Press Vessels Piping 2006;83:645-53]. The solutions are valid for ratios of the branch-to-run pipe radius and thickness from 0.4 to 1.0, and for the mean radius-to-thickness ratio of the run pipe from 10.0 to 20.0. Moreover, the solutions considered the case of in-plane bending only on the branch pipe. This paper extends the previous solutions in two aspects. Firstly, plastic limit load solutions are given also for in-plane bending on the run pipe. Secondly, the validity of the proposed solutions is extended to ratios of the branch-to-run pipe radius and thickness from 0.0 to 1.0, and the mean radius-to-thickness ratio of the run pipe from 5.0 to 20.0. Comparisons with FE results show good agreement

A data-driven approach to modeling high-density terminal areas: A scenario analysis of the new Beijing, China airspace

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Max Z. Li

2017-04-01

Full Text Available Airports are being developed and expanded rapidly in China to accommodate and promote a growing aviation market. The future Beijing Daxing International Airport (DAX will serve as the central airport of the JingJinJi megaregion, knitting the Beijing, Tianjin, and Hebei regions together. DAX will be a busy airport from its inception, relieving congestion and accommodating growth from Beijing Capital International Airport (PEK, currently the second busiest airport in the world in passengers moved. We aim to model terminal airspace designs and possible conflicts in the future Beijing Multi-Airport System (MAS. We investigate standard arrival procedures and mathematically model current and future arrival trajectories into PEK and DAX by collecting large quantities of publicly available track data from historical arrivals operating within the Beijing terminal airspace. We find that (1 trajectory models constructed from real data capture aberrations and deviations from standard arrival procedures, validating the need to incorporate data on historical trajectories with standard procedures when evaluating the airspace and (2 given all existing constraints, DAX may be restricted to using north and east arrival flows, constraining the capacity required to handle the increases in air traffic demand to Beijing. The results indicate that the terminal airspace above Beijing, and the future JingJinJi region, requires careful consideration if the full capacity benefits of the two major airports are to be realized.

Produktiwiteit en verantwoordelikheid, enkele sielkundige aspekte

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A. P. Venter

1978-11-01

Maslow se motiveringsteorie wat uit die kliniese sielkunde ontspruit het, is ook deur bedryfsielkundiges van nader beskou, veral in hoe verre dit met produktiwiteit verband het. Enkele sielkundige aspekte word bespreek ten einde op die nut van hierdie teorie in die bedryfsituasie te wys. Die vermoede bestaan dat die teorie deur bedryfsielkundiges nie altyd korrek vertolk word soos Maslow dit self uiteensit nie; veral word die verantwoordelikheidsaspek in die selfuitlewingsbehoeftes misken en nie verreken nie; 'n Logiese konklusie is dat selfuitlewing, soos deur Maslow beskryf, wel verband met produktiwiteit het.

75 FR 20998 - Ocean Transportation Intermediary License Revocation

Science.gov (United States)

2010-04-22

...: 3302F. Name: Chol In Kim dba Unimax International Company. Address: 16901 South Keegan Avenue, Carson..., Inc. Address: 16901 South Keegan Avenue, Carson, Ca 90746. Date Revoked: March 30, 2010. Reason...

A time for new north–south relationships in global health

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Kim JU

2017-11-01

Full Text Available Jin Un Kim,1 Obinna Oleribe,2 Ramou Njie,3 Simon D Taylor-Robinson1 1Division of Digestive Health, Department of Surgery and Cancer, Imperial College London, London, UK; 2Excellence and Friends Management Care Centre, Abuja, Nigeria; 3MRC, Serekunda, The Gambia Abstract: The modern concept of globalization in health care and clinical research often carries a positive message for the “Global South” nations of Africa, South America and Southeast Asia. However, bioethical abuse of participants in clinical trials still exists in the Global South. Unethical studies directed by the “Global North”, formed by the medically advanced nations in North America, Western Europe and Japan, have been hugely concerning. The issue between the Global North and South is a well-recognized socioeconomic phenomenon of globalization. Medical exploitation has its roots in the socioeconomic interactions of a postcolonial world, and solutions to reducing exploitation require a deeper understanding of these societal models of globalization. We explore the fundamental causes of imbalance and suggest solutions. Reflecting on the globalization model, there must be an effort to empower the Global South nations to direct and govern their own health care systems efficiently on the basis of equality. Keywords: global health, bioethics, clinical trials, Africa, exploitation, imperialism

PREFACE: International Conference on Inverse Problems 2010

Science.gov (United States)

Hon, Yiu-Chung; Ling, Leevan

2011-03-01

Following the first International Conference on Inverse Problems - Recent Theoretical Development and Numerical Approaches held at the City University of Hong Kong in 2002, the fifth International Conference was held again at the City University during December 13-17, 2010. This fifth conference was jointly organized by Professor Yiu-Chung Hon (Co-Chair, City University of Hong Kong, HKSAR), Dr Leevan Ling (Co-Chair, Hong Kong Baptist University, HKSAR), Professor Jin Cheng (Fudan University, China), Professor June-Yub Lee (Ewha Womans University, South Korea), Professor Gui-Rong Liu (University of Cincinnati, USA), Professor Jenn-Nan Wang (National Taiwan University, Taiwan), and Professor Masahiro Yamamoto (The University of Tokyo, Japan). It was agreed to alternate holding the conference among the above places (China, Japan, Korea, Taiwan, and Hong Kong) once every two years. The next conference has been scheduled to be held at the Southeast University (Nanjing, China) in 2012. The purpose of this series of conferences is to establish a strong collaborative link among the universities of the Asian-Pacific regions and worldwide leading researchers in inverse problems. The conference addressed both theoretical (mathematics), applied (engineering) and developmental aspects of inverse problems. The conference was intended to nurture Asian-American-European collaborations in the evolving interdisciplinary areas and it was envisioned that the conference would lead to long-term commitments and collaborations among the participating countries and researchers. There was a total of more than 100 participants. A call for the submission of papers was sent out after the conference, and a total of 19 papers were finally accepted for publication in this proceedings. The papers included in the proceedings cover a wide scope, which reflects the current flourishing theoretical and numerical research into inverse problems. Finally, as the co-chairs of the Inverse Problems

The Militia of Jin-Cha-Ji Border Area in the Anti-Japanese War Period%抗战时期晋察冀边区的民兵

Institute of Scientific and Technical Information of China (English)

栾盈菊

2013-01-01

晋察冀民兵是在共产党的动员和领导下建立和壮大起来的不脱离生产的群众武装。民兵的任务是进行游击战、配合部队作战和担任抗战勤务。民兵的军事战术有麻雀战、地雷战、地道战、扭击战和伏击战等。在民兵队伍中，由于有党的政治动员、党员的带头作用、有组织的军事政治教育和组织的民主性等原因，民兵成为打败日寇的重要力量，同时民兵也是主力军与游击队的助手，是主力军的重要兵源。%The militia of Jin-Cha-Ji border area was the armed masses without departing from the pro-duction,which was established and grew under the leadership of the Party.Its mission was to carry outguerrilla warfare,cooperate with the troops and act as war service.It had many tactics,such as sparrowwarfare,mine warfare,tunnel warfare,torsional warfare and ambush operation.Due to the Party’s politi-cal mobilization and the Party members’leading role,with organized military and political education anddemocratic nature of the organization,the militia was not only an important force to beat the Japanese,butalso assistant of the main force and the guerrillas,and the important sources for the recruits of the mainforce troops.

X-ray Radiation Mechanisms and the Beaming Effect of Hot Spots ...

Indian Academy of Sciences (India)

Astr. (2011) 32, 193–196 c Indian Academy of Sciences. X-ray Radiation Mechanisms and the Beaming Effect of Hot Spots and Knots in AGN Jets. Jin Zhang1,∗. , Jin-Ming Bai2, Liang Chen2 & Enwei Liang3. 1College of Physics and Electronic Engineering, Guangxi Teachers Education University,. Nanning 530001, China.

Modification of the internal electric field by biasing of the divertor plates in the Tokamak de Varennes (TdeV)

International Nuclear Information System (INIS)

Lafrance, D.; Huang, R.; Stansfield, B.L.; Haddad, E.; Lachambre, J.

1997-01-01

The radial electric field inside the separatrix has been deduced from spectroscopic measurements of impurities on TdeV (Tokamak de Varennes), using the reduced radial momentum balance and two neoclassical models [R. D. Hazeltine, Phys. Fluids 17, 961 (1974) and Y. B. Kim, P. H. Diamond, and R. J. Groebner, Phys. Fluids B 3, 2050 (1991)]. The results from all three models are in fair agreement. Furthermore, the electric field has been deduced using the same models both with and without biasing the divertor plates relative to the machine wall, showing an inward propagation of the effect of the biasing created in the scrape-off layer (SOL). Undeniably, the electric field has been modified well inside the separatrix (0.6 approx-lt r/a approx-lt 0.9), revealing the possibility of modifying the internal electric field by external means. copyright 1997 American Institute of Physics

Academic stress and positive affect: Asian value and self-worth contingency as moderators among Chinese international students.

Science.gov (United States)

Liao, Kelly Yu-Hsin; Wei, Meifen

2014-01-01

The theoretical model proposed by Berry and colleagues (Berry, 1997; Berry, Kim, Minde, & Mok, 1987) highlights the importance of identifying moderators in the acculturation process. Accordingly, the current study examined the Asian cultural value of family recognition through achievement (FRTA) and contingency of self-worth on academic competence (CSW-AC) as moderators in the association between academic stress and positive affect among Chinese international students. A total of 370 Chinese international students completed online surveys. Results from a hierarchical regression indicated that while academic stress was negatively associated with positive affect, FRTA was positively associated with positive affect. In other words, those with high academic stress reported a lower level of positive affect. However, individuals who endorsed high levels of FRTA reported a higher level of positive affect. In addition, results also revealed a significant interaction between academic stress and CSW-AC on positive affect. Thus, the study's finding supported the moderator role of CSW-AC. Simple effect analyses were conducted to examine the significant interaction. The results showed that higher levels of CSW-AC strengthened the negative association between academic stress and positive affect but lower levels of CSW-AC did not. Future research directions and implications are discussed.

Effect of self-assembled peptide–mesenchymal stem cell complex on the progression of osteoarthritis in a rat model

Directory of Open Access Journals (Sweden)

Kim JE

2014-05-01

Full Text Available Ji Eun Kim,1 Sang Mok Lee,2 Soo Hyun Kim,1 Phil Tatman,3 Albert O Gee,4 Deok-Ho Kim,3,5 Kyung Eun Lee,6 Youngmee Jung,1 Sang Jun Kim21Biomaterials Research Center, Korea Institute of Science and Technology, Seoul, South Korea; 2Department of Physical and Rehabilitation Medicine, Samsung Medical Center, Seoul, South Korea; 3Department of Bioengineering, 4Department of Orthopaedics and Sports Medicine, 5Institute for Stem Cell and Regenerative Medicine and Center for Cardiovascular Biology, University of Washington, Seattle, WA, USA; 6Advanced Analysis Center, Korea Institute of Science and Technology, Seoul, South KoreaPurpose: To evaluate the efficacy of mesenchymal stem cells (MSCs encapsulated in self-assembled peptide (SAP hydrogels in a rat knee model for the prevention of osteoarthritis (OA progression.Materials and methods: Nanostructured KLD-12 SAPs were used as the injectable hydrogels. Thirty-three Sprague Dawley rats were used for the OA model. Ten rats were used for the evaluation of biotin-tagged SAP disappearance. Twenty-three rats were divided into four groups: MSC (n=6, SAP (n=6, SAP-MSC (n=6, and no treatment (n=5. MSCs, SAPs, and SAP-MSCs were injected into the knee joints 3 weeks postsurgery. Histologic examination, immunofluorescent staining, measurement of cytokine levels, and micro-computed tomography analysis were conducted 6 weeks after injections. Behavioral studies were done to establish baseline measurements before treatment, and repeated 3 and 6 weeks after treatment to measure the efficacy of SAP-MSCs.Results: Concentration of biotinylated SAP at week 1 was not significantly different from those at week 3 and week 6 (P=0.565. Bone mineral density was significantly lower in SAP-MSC groups than controls (P=0.002. Significant differences in terminal deoxynucleotidyl transferase deoxyuridine triphosphate nick-end labeling staining between the control group and all other groups were observed. Caspase-8, tissue inhibitor of

Eestlased Pekingi biennaalil

Index Scriptorium Estoniae

2005-01-01

20. IX avatud Pekingi II kunstibiennaalist, mille peakuraatoriteks on Jin Shangyi, Liu Dawei ja Feng Yuan. Eestit esindavad biennaalil Leo Lapini maal seeriast "Kood", Jaan Toomiku maal "Mees metsas", Anne-Daniela Saaliste ja Paul Rodgersi kineetiline installatsioon "Karusell". Hefeis toimus IAA (International Association of Art) XVI konverents ja assamblee. IAA uueks esimeheks valiti Liu Dawei Hiinast. Hefei Anmei kunstilinnakus avati 23. VIII näitus peaassambleel esindatud kunstnikeorganisatsioonide delegaatide-kunstnike töödest, kus Eestist oli väljas Jaan Elkeni maal "Preemia"

China's 'recycling economy'

DEFF Research Database (Denmark)

Mehlsen, Camilla

2009-01-01

Climate change and sustainability are hot topics in China, but it is hard to find research addressing the outcomes of Education for Sustainable Development, says Associate Professor Yi Jin.......Climate change and sustainability are hot topics in China, but it is hard to find research addressing the outcomes of Education for Sustainable Development, says Associate Professor Yi Jin....

Antifungal activity of epithelial secretions from selected frog species ...

African Journals Online (AJOL)

Ezedom Theresa

2013-11-06

Nov 6, 2013 ... Chemical stimulation gave the best yield by mass, and secretions from A. fuscigula showed the best ..... electrical stimulation (Dourado et al., 2007; Kim et al.,. 2007 .... Hematopoietic Stem Cell Transplants: An International.

ICWIP 2008

Indian Academy of Sciences (India)

Scope: The 3rd IUPAP International Conference on Women in Physics (ICWIP 2008) will be held ... Maki Kawai (The Institute of Physical and Chemical Research, Japan). Young-Kee Kim ... Hyunggyu Park (Korea Institute for Advanced Study).

Joint Institute for Nanoscience Annual Report 2003

Energy Technology Data Exchange (ETDEWEB)

Baer, Donald R.; Campbell, Charles

2004-02-01

The Joint Institute for Nanoscience (JIN) is a cooperative venture of the University of Washington and Pacific Northwest National Laboratory to encourage and enhance high-impact and high-quality nanoscience and nanotechnology of all types. This first annual report for the JIN summarizes activities beginning in 2001 and ending at the close of fiscal year 2003 and therefore represents somewhat less than two years of activities. Major portions of the JIN resources are dedicated to funding graduate students and postdoctoral research associates to perform research in collaborations jointly directed by Pacific Northwest National Laboratory (PNNL) staff scientists and University of Washington (UW) professors. These fellowships were awarded on the basis of applications that included research proposals. JIN co-sponsors an annual Nanoscale Science and Technology Workshop held in Seattle. In addition to involving PNNL staff in various UW nanoscience courses and seminars, a National Science Foundation grant Development of UW-PNL Collaborative Curriculums in Nano-Science and Technology has allowed the development of three intensive short courses that are taught by UW faculty, PNNL staff, and faculty from other institutions, including Washington State University, the University of Idaho, Stanford University, and the University of Alaska. The initial JIN agreement recognized that expansion of cooperation beyond UW and PNNL would be highly valuable. Starting in early 2003, efforts were initiated to form a regional communication link called the Northwest Nanoscience and Nanotechnology Network (N₄). In concept, N₄ is a tool to encourage communication and help identify regional resources and nanoscience and technology activities.

Internal structure of an ex-vessel corium debris bed during severe accidents of LWRs

Energy Technology Data Exchange (ETDEWEB)

Kim, Eunho; Park, Jin Ho; Moriyama, Kiyofumi; Park, Hyun Sun [POSTECH, Daejeon (Korea, Republic of)

2015-10-15

In the aspect of the coolability assessment the configuration of the debris bed, including internal and external characteristics, has significant importance as boundary conditions for simulations, however, relatively little investigation of the sedimentation process. For the development of a debris bed, recently there have been several studies that focused on thermal characteristics of corium particles. Yakush et al. performed simulation studies and showed that two phase natural convection affects the particle settling trajectory and changes the final arrival location of particles to result more flattened bed. Those simulation results have been supported by the experimental studies of Kim et al. using simulant particles and air bubble injection. For the internal structure of a debris bed, there have been several simulation and experimental studies, which investigated the effect of internal structure on debris bed coolability. Magallon has reported the particle size distribution at three elevations of the debris bed of FARO L-31 case, where the mean particle size was bigger for the lower elevation. However, there is a lack of detailed information on the characteristics of the debris bed, including the local structure and porosity. In this study, we investigated the internal structure of the debris bed using a mixture of stainless steel particles and air bubble injection. Local particle sedimentation quantity, particle size distribution change in radial direction and axial direction, and bed porosity was measured to investigate a relationship between the internal structure and the accident condition. An experimental investigation was carried out for the internal structure of ex-vessel corium debris bed in the flooded cavity during sever accident. Moderate corium discharge in high flooding level was assumed for full fragmentation of melt jet. The test particle mixture was prepared by following an empirical correlation, which reflects the particle size distribution of

Internal structure of an ex-vessel corium debris bed during severe accidents of LWRs

International Nuclear Information System (INIS)

Kim, Eunho; Park, Jin Ho; Moriyama, Kiyofumi; Park, Hyun Sun

2015-01-01

In the aspect of the coolability assessment the configuration of the debris bed, including internal and external characteristics, has significant importance as boundary conditions for simulations, however, relatively little investigation of the sedimentation process. For the development of a debris bed, recently there have been several studies that focused on thermal characteristics of corium particles. Yakush et al. performed simulation studies and showed that two phase natural convection affects the particle settling trajectory and changes the final arrival location of particles to result more flattened bed. Those simulation results have been supported by the experimental studies of Kim et al. using simulant particles and air bubble injection. For the internal structure of a debris bed, there have been several simulation and experimental studies, which investigated the effect of internal structure on debris bed coolability. Magallon has reported the particle size distribution at three elevations of the debris bed of FARO L-31 case, where the mean particle size was bigger for the lower elevation. However, there is a lack of detailed information on the characteristics of the debris bed, including the local structure and porosity. In this study, we investigated the internal structure of the debris bed using a mixture of stainless steel particles and air bubble injection. Local particle sedimentation quantity, particle size distribution change in radial direction and axial direction, and bed porosity was measured to investigate a relationship between the internal structure and the accident condition. An experimental investigation was carried out for the internal structure of ex-vessel corium debris bed in the flooded cavity during sever accident. Moderate corium discharge in high flooding level was assumed for full fragmentation of melt jet. The test particle mixture was prepared by following an empirical correlation, which reflects the particle size distribution of

Design of a novel theranostic nanomedicine: synthesis and physicochemical properties of a biocompatible polyphosphazene–platinum(II conjugate

Directory of Open Access Journals (Sweden)

Avaji PG

2016-03-01

Full Text Available Prakash G Avaji,1,2,* Jung Hyun Park,1,* Hyun Jeong Lee,1 Yong Joo Jun,2 Kyung Su Park,3 Kyung Eun Lee,3 Soo-Jin Choi,4 Hwa Jeong Lee,1 Youn Soo Sohn2 1Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Republic of Korea; 2C & Pharm, Ewha Womans University, Seoul, Republic of Korea; 3Advanced Analysis Center, Korea Institute of Science and Technology, Seoul, Republic of Korea; 4Department of Food Science and Technology, Seoul Women’s University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: To develop a theranostic nanomedicine involving the antitumor-active moiety (dachPt(II (dach: trans-(±-1,2-diaminocyclohexane of oxaliplatin (OX, a new biocompatible polyphosphazene carrier polymer was designed by grafting with a methoxy poly(ethylene glycol (MPEG to increase duration of circulation in the blood and with aminoethanol (AE as a spacer group. The antitumor (dachPt moiety was conjugated to the carrier polymer using cis-aconitic acid (AA as a linker, resulting in a polymer conjugate formulated as [NP(MPEG550(AE-AAPt(dach]n, named “Polyplatin” (PP. PP was found to self-assemble into very stable polymeric nanoparticles with a mean diameter of 55.1 nm and a critical aggregation concentration of 18.5 mg/L in saline. PP could easily be labeled with a fluorescence dye such as Cy5.5 for imaging studies. The time-dependent ex vivo image studies on organ distributions and clearance of Cy-labeled PP have shown that PP accumulated in the tumor with high selectivity by the enhanced permeability and retention effect but was cleared out from all the major organs including the liver in about 4 weeks postinjection. Another time-dependent bioimaging study on distribution and clearance of PP in mouse kidney using laser ablation inductively coupled plasma mass spectroscopy has shown that PP accumulates much less in kidney and is more rapidly excreted than monomeric OX, which is in accord with the

Retraction RETRACTION of "Methylation of the RASSFIA promoter in breast cancer" by Y. Ji, H.H. Jin, M.D. Wang, W.X. Cao, J.L. Bao - Genet. Mol. Res. 15 (2): gmr.15028261 (2016) - DOI: 10.4238/gmr.15028261.

Science.gov (United States)

Ji, Y; Jin, H H; Wang, M D; Cao, W X; Bao, J L

2016-10-07

The retracted article is: Ji Y, Jin HH, Wang MD, Cao WX, et al. (2016). Methylation of the RASSFIA promoter in breast cancer. Genet. Mol. Res. 15: gmr.15028261. There are significant parts of this article (particularly, in the discussion section) that are copied from "Methylation of HIN-1, RASSF1A, RIL and CDH13 in breast cancer is associated with clinical characteristics, but only RASSF1A methylation is associated with outcome", by Jia Xu, Priya B Shetty, Weiwei Feng, Carol Chenault, Robert C Bast Jr, Jean-Pierre J Issa, Susan G Hilsenbeck and Yinhua Yu, published in BMC Cancer 2012; 12: 243. DOI: 10.1186/1471-2407-12-243. The first paragraphs of both discussions are identical. This is concerning. The abstract and introduction sections have much of their text plagiarized. Overall, there is high plagiarism detected. The GMR editorial staff was alerted and after a thorough investigation, we have strong reason to believe that the peer review process was failure and, after review and contacting the authors, the editors of Genetics and Molecular Research decided to retract the article in accordance with the recommendations of the Committee on Publication Ethics (COPE). The authors and their institutions were advised of this serious breach of ethics.

Standards of Justice for Human Being and Doing in Kim Stanley Robinson’s 2312 and C. S. Friedman’s This Alien Shore

Directory of Open Access Journals (Sweden)

Claire P. Curtis

2017-09-01

Full Text Available The creation of superior societies and communities in which bodies live better and thrive depends on richly detailed accounts of imagined societies including flexible theories of justice that can be used to evaluate them. Both Kim Stanley Robinson’s '2312' (2012 and C. S. Friedman’s 'This Alien Shore' (1998 attempt to rethink what bodies can do and be, by exploring ways of living together among those with different, and differently compatible, bodies. The novels are set in future spacefaring societies away from the Earth, which nevertheless struggle with the fact of Earth’s existence. Each novel describes radical cognitive and bodily change: chosen alteration in '2312' and environmental transformation in 'This Alien Shore'. In each novel, the body, and what bodies can do and be, is a central issue. But how might we evaluate the societies these novels describe to gauge their contributions to articulating desires for a better way of being? In this article I employ Martha Nussbaum’s ‘capabilities approach’ (encompassing life, bodily health, bodily integrity, senses, emotions, reason, affiliation, play, other species, control over environment to think about justice in the articulation of evaluative standards. In so doing the analysis I develop addresses some key questions raised by these novels, including: Whose body will matter? Will there be bodily norms? How will communities confront different bodily abilities? How can we enhance our own thinking about how to live in and among bodies? How does (and should the idea of the body politic change when our expectations about bodies changes?

Cut-off value of FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction in a Korean population

Directory of Open Access Journals (Sweden)

Chung KS

2016-08-01

Full Text Available Kyung Soo Chung,1,2 Ji Ye Jung,1,2 Moo Suk Park,1,2 Young Sam Kim,1,2 Se Kyu Kim,1,2 Joon Chang,1,2 Joo Han Song1,2 1Division of Pulmonology, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea; 2Institute of Chest Disease, Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea Background: Forced expiratory volume in 1 second (FEV1/forced expiratory volume in 6 seconds (FEV6 has been proposed as an alternative to FEV1/forced vital capacity (FVC for detecting airway obstruction. A fixed cut-off value for FEV1/FEV6 in a Korean population is lacking. We investigated a fixed cut-off for FEV1/FEV6 as a surrogate for FEV1/FVC for detecting airway obstruction.Materials and methods: We used data obtained in the 5 years of the Fifth and Sixth Korean National Health and Nutrition Examination Survey. A total of 14,978 participants aged ≥40 years who underwent spirometry adequately were the study cohort. “Airway obstruction” was a fixed cut-off FEV1/FVC <70% according to the Global Initiative for Chronic Obstructive Lung Disease guidelines. We also used European Respiratory Society/Global Lung Initiative 2012 equations for the FEV1/FVC lower limit of normal.Results: Among the 14,978 participants (43.5% male, 56.5% female; mean age: 56.9 years for men and 57.0 years for women, 14.0% had obstructive lung function according to a fixed cut-off FEV1/FVC <70%. Optimal FEV1/FEV6 cut-off for predicting FEV1/FVC <70% was 75% using receiver operating characteristic curve analyses (area under receiver operating characteristic curve =0.989, 95% confidence interval 0.987–0.990. This fixed cut-off of FEV1/FEV6 showed 93.8% sensitivity, 94.8% specificity, 74.7% positive predictive value, 98.9% negative predictive value, and 0.8 Cohen’s kappa coefficient. When compared with FEV1/FVC < lower limit of normal, FEV1/FEV6 <75% tended to over-diagnose airflow limitation (just like a fixed cut

The metabolic consequences of thyroxine replacement in adult hypopituitary patients

DEFF Research Database (Denmark)

Filipsson Nyström, Helena; Feldt-Rasmussen, Ulla; Kourides, Ione

2012-01-01

The metabolic consequences of thyroxine replacement in patients with central hypothyroidism (CH) need to be evaluated. The aim was to examine the outcome of thyroxine replacement in CH. Adult hypopituitary patients (n = 1595) with and without CH from KIMS (Pfizer International Metabolic Database...

Synthesis, toxicity, biocompatibility, and biomedical applications of graphene and graphene-related materials

Directory of Open Access Journals (Sweden)

Gurunathan S

2016-05-01

Full Text Available Sangiliyandi Gurunathan, Jin-Hoi Kim Stem Cell and Regenerative Biology, Konkuk University, Seoul, Republic of Korea Abstract: Graphene is a two-dimensional atomic crystal, and since its development it has been applied in many novel ways in both research and industry. Graphene possesses unique properties, and it has been used in many applications including sensors, batteries, fuel cells, supercapacitors, transistors, components of high-strength machinery, and display screens in mobile devices. In the past decade, the biomedical applications of graphene have attracted much interest. Graphene has been reported to have antibacterial, antiplatelet, and anticancer activities. Several salient features of graphene make it a potential candidate for biological and biomedical applications. The synthesis, toxicity, biocompatibility, and biomedical applications of graphene are fundamental issues that require thorough investigation in any kind of applications related to human welfare. Therefore, this review addresses the various methods available for the synthesis of graphene, with special reference to biological synthesis, and highlights the biological applications of graphene with a focus on cancer therapy, drug delivery, bio-imaging, and tissue engineering, together with a brief discussion of the challenges and future perspectives of graphene. We hope to provide a comprehensive review of the latest progress in research on graphene, from synthesis to applications. Keywords: biomedical applications, cancer therapy, drug delivery, graphene, graphene-related materials, tissue engineering, toxicity 

Titanium dioxide induces apoptotic cell death through reactive oxygen species-mediated Fas upregulation and Bax activation

Directory of Open Access Journals (Sweden)

Yoon TH

2012-03-01

Full Text Available Ki-Chun Yoo1, Chang-Hwan Yoon1, Dongwook Kwon2, Kyung-Hwan Hyun1, Soo Jung Woo1, Rae-Kwon Kim1, Eun-Jung Lim1, Yongjoon Suh1, Min-Jung Kim1, Tae Hyun Yoon2, Su-Jae Lee11Laboratory of Molecular Biochemistry, 2Laboratory of Nanoscale Characterization and Environmental Chemistry, Department of Chemistry, Hanyang University, Seoul, Republic of KoreaBackground: Titanium dioxide (TiO2 has been widely used in many areas, including biomedicine, cosmetics, and environmental engineering. Recently, it has become evident that some TiO2 particles have a considerable cytotoxic effect in normal human cells. However, the molecular basis for the cytotoxicity of TiO2 has yet to be defined.Methods and results: In this study, we demonstrated that combined treatment with TiO2 nanoparticles sized less than 100 nm and ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-dependent upregulation of Fas and conformational activation of Bax in normal human cells. Treatment with P25 TiO2 nanoparticles with a hydrodynamic size distribution centered around 70 nm (TiO2P25–70 together with ultraviolet A irradiation-induced caspase-dependent apoptotic cell death, accompanied by transcriptional upregulation of the death receptor, Fas, and conformational activation of Bax. In line with these results, knockdown of either Fas or Bax with specific siRNA significantly inhibited TiO2-induced apoptotic cell death. Moreover, inhibition of reactive oxygen species with an antioxidant, N-acetyl-L-cysteine, clearly suppressed upregulation of Fas, conformational activation of Bax, and subsequent apoptotic cell death in response to combination treatment using TiO2P25–70 and ultraviolet A irradiation.Conclusion: These results indicate that sub-100 nm sized TiO2 treatment under ultraviolet A irradiation induces apoptotic cell death through reactive oxygen species-mediated upregulation of the death receptor, Fas, and activation of the preapoptotic protein

Pharmacokinetic interactions between glimepiride and rosuvastatin in healthy Korean subjects: does the SLCO1B1 or CYP2C9 genetic polymorphism affect these drug interactions?

Directory of Open Access Journals (Sweden)

Kim CO

2017-02-01

Full Text Available Choon Ok Kim,1 Eun Sil Oh,2 Hohyun Kim,3 Min Soo Park1,4 1Department of Clinical Pharmacology, Severance Hospital, Yonsei University College of Medicine, Seoul, 2Department of Pharmaceutical Medicine and Regulatory Sciences, College of Medicine and Pharmacy, Yonsei University, Incheon, 3Korea Medicine Research Institute, Inc., Seongnam, 4Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea Abstract: To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these patients are likely to take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed to evaluate the pharmacokinetic (PK interactions between these two drugs in healthy males and to explore the effect of SLCO1B1 and CYP2C9 polymorphisms on their interactions in two randomized, open-label crossover studies. Glimepiride was studied in part 1 and rosuvastatin in part 2. Twenty-four participants were randomly assigned to each part. All subjects (n=24 completed part 1, and 22 subjects completed part 2. A total of 38 subjects among the participants of the PK interaction studies were enrolled in the genotype study to analyze their SLCO1B1 and CYP2C9 polymorphisms retrospectively (n=22 in part 1, n=16 in part 2. Comparison of the PK and safety of each drug alone with those of the drugs in combination showed that both glimepiride and rosuvastatin did not interact with each other and had tolerable safety profiles in all subjects. However, with regard to glimepiride PK, the SLCO1B1 521TC group had a significantly higher maximum plasma concentration (Cmax,ss and area under the plasma concentration–time curve during the dose interval at steady state (AUCt,ss for glimepiride in combination with rosuvastatin than those for glimepiride alone. However, other significant effects of the SLCO1B1 or CYP2C9 polymorphism on the interaction between the two drugs were not observed. In conclusion, there were no significant PK

Silicon improves salt tolerance by increasing root water uptake in Cucumis sativus L.

Science.gov (United States)

Zhu, Yong-Xing; Xu, Xuan-Bin; Hu, Yan-Hong; Han, Wei-Hua; Yin, Jun-Liang; Li, Huan-Li; Gong, Hai-Jun

2015-09-01

Silicon enhances root water uptake in salt-stressed cucumber plants through up-regulating aquaporin gene expression. Osmotic adjustment is a genotype-dependent mechanism for silicon-enhanced water uptake in plants. Silicon can alleviate salt stress in plants. However, the mechanism is still not fully understood, and the possible role of silicon in alleviating salt-induced osmotic stress and the underlying mechanism still remain to be investigated. In this study, the effects of silicon (0.3 mM) on Na accumulation, water uptake, and transport were investigated in two cucumber (Cucumis sativus L.) cultivars ('JinYou 1' and 'JinChun 5') under salt stress (75 mM NaCl). Salt stress inhibited the plant growth and photosynthesis and decreased leaf transpiration and water content, while added silicon ameliorated these negative effects. Silicon addition only slightly decreased the shoot Na levels per dry weight in 'JinYou 1' but not in 'JinChun 5' after 10 days of stress. Silicon addition reduced stress-induced decreases in root hydraulic conductivity and/or leaf-specific conductivity. Expressions of main plasma membrane aquaporin genes in roots were increased by added silicon, and the involvement of aquaporins in water uptake was supported by application of aquaporin inhibitor and restorative. Besides, silicon application decreased the root xylem osmotic potential and increased root soluble sugar levels in 'JinYou 1.' Our results suggest that silicon can improve salt tolerance of cucumber plants through enhancing root water uptake, and silicon-mediated up-regulation of aquaporin gene expression may in part contribute to the increase in water uptake. In addition, osmotic adjustment may be a genotype-dependent mechanism for silicon-enhanced water uptake in plants.

Die wese, doel en belangrikheid van liggaamlike opvoeding in 'n moderne kulturele samelewing en die prinsipiële grondbeginsels waarop dit moet berus*

Directory of Open Access Journals (Sweden)

I. R. van der Merwe

1963-03-01

Full Text Available Om dat die begrip Liggaamlike Opvoeding in die alledaagsc taalgebruik ligtclik assosieer word o.a. m et sulke begrippe soos sport, liggaamsoefeninge, in Engels m et physical culture; in Duits m et kórpcrerziehung; in Grieks met gym nastiek en andcr moontlike m isleidende begrippe in aanverw ante tale, en om dat in die alledaagse spreek- taal daar wanopvattings ook kan bestaan i.v.m. so ’n begrip soos kultuur, wil ons dan ten einde m isverstand uit die weg te ruim , vir eers kortliks nagaan w at presies onder die begrippe K ultuur en Liggaamlike Opvoeding verstaan moet word voordat ’n poging aangewend w ord om bogenoemde onderwerp te ondersoek.

Self-perceived cognitive deficits and their relationship with internalized stigma and quality of life in patients with schizophrenia

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Shin YJ

2016-06-01

Full Text Available Yeon-Jeong Shin,1,2 Yo-Han Joo,1 Jong-Hoon Kim1–3 1Neuroscience Research Institute, 2Department of Health Sciences and Technology, Gachon Advanced Institute for Health Sciences & Technology, 3Department of Psychiatry, Gil Medical Center, Gachon University School of Medicine, Gachon University, Incheon, Republic of Korea Background: We investigated self-perceived cognitive deficits and their relationship with internalized stigma and quality of life in patients with schizophrenia in order to shed light on the clinical correlates of subjective cognitive deficits in schizophrenia.Methods: Seventy outpatients with schizophrenia were evaluated. Patients’ self-perceived cognitive deficits, internalized stigma, and subjective quality of life were assessed using the Scale to Investigate Cognition in Schizophrenia (SSTICS, the Internalized Stigma of Mental Illness Scale (ISMI, and the Schizophrenia Quality of Life Scale Revision 4 (SQLS-R4, respectively. Correlation and regression analyses controlling for the severity of symptoms of schizophrenia were performed, and a mediation analysis was conducted to examine the hypothesis that internalized stigma mediates the relationship between self-perceived cognitive deficits and subjective quality of life.Results: Pearson’s partial correlation analysis showed significant correlations among the SSTICS, ISMI, and SQLS-R4 scores (P<0.01. Multiple regression analysis showed that the SSTICS and ISMI scores significantly predicted the SQLS-R4 score (P<0.01. Mediation analysis revealed that the strength of the association between the SSTICS and SQLS-R4 scores decreased from β=0.74 (P<0.01 to β=0.56 (P<0.01, when the ISMI score was statistically controlled. The Sobel test revealed that this difference was significant (P<0.01, indicating that internalized stigma partially mediated the relationship between self-perceived cognitive deficits and quality of life.Conclusion: The present study indicates that self

"Improtest" kui "improbleem" / Tõnis Kahu

Index Scriptorium Estoniae

Kahu, Tõnis, 1962-

2009-01-01

Improvisatsioonilise muusika kontserdisarjast "Improtest", sarja hooaja avakontserdist, kus esines prantsuse kitarrist Jean-Francois Pauvros. "Improtesti" eestvedajad Taavi Kerikmäe ja Mart Soo vastavad küsimustele

Tracking Theory Building and Use Trends in Selected LIS Journals: More Research is Needed. A review of: Kim, Sung‐Jin, and Dong Y. Jeong. “An Analysis of the Development and Use of Theory in Library and Information Science Research Articles.” Library & Information Science Research 28.4 (Sept. 2006: 548‐62.

Directory of Open Access Journals (Sweden)

Carol Perryman

2007-09-01

Full Text Available Objective ‐ The authors measure theory incidents occurring in four LIS journals between 1984‐2003 in order to examine their number and quality and to analyze them by topic. A third objective, only identified later in the text of the study, was to compare theory development and use between Korean and international journals. Research questions asked include whether LIS has its own theoretical base as a discipline, and what characteristics the theoretical framework has.Design – Bibliometric study.Setting – Journal issues selected from four LIS journals for the time span from 1984 ‐ 2003.Subjects – Two international journals, Journal of the American Society for Information Science and Technology (JASIST and Library and Information Science Research (LISR were selected based on their high ranking in the Social Sciences Citation Index (SSCI impact factors. Two Korean journals, Journal of the Korean Society for Information Management (JKSIM and Journal of the Korean Society for Library and Information Science (JKSLIS were selected.Methods ‐ After having determined a definition of theory, and identifying different levels of theory, the authors set up rules for the identification of theory incidents, which are defined as “events in which the author contributed to the development or the use of theory in his/her own paper” (550. Content analysis of 1661 research articles was performed to measure theory incidents according to working definitions. Interrater reliability was ensured by conducting independent coding for “subfield classification, identification of theory incidents, and quality measurement” (555,using a sample of 199 articles (random selection not specified, achieving 94‐97% interrater reliability. Incidents, once identified, were evaluated for quality using Dubin’s “efficiency of law” criteria, involving measures of relatedness, directionality, co‐variation, rate of change, and “profundity,” defined as the

Research-Based Design of Pedagogical Agent Roles: A Review, Progress, and Recommendations

Science.gov (United States)

Kim, Yanghee; Baylor, Amy L.

2016-01-01

In this paper we review the contribution of our original work titled "Simulating Instructional Roles Through Pedagogical Agents" published in the "International Journal of Artificial Intelligence and Education" (Baylor and Kim in "Computers and Human Behavior," 25(2), 450-457, 2005). Our original work operationalized…

Ranking Different Stakeholder-Driven Definitions of Academic Quality

Science.gov (United States)

Shouba, Derek

2017-01-01

Americans are increasingly concerned about academic quality (Hauptman & Kim, 2009). This concern about academic quality is a product of the relative decline of the American economy, American Program for International Student Assessment (PISA) test scores, American baccalaureate attainment rates, and various other indicators of national…

A Randomized, Double-Blind, Placebo-Controlled Crossover Study of the Anti-Inflammatory Compound Anatabine to Treat Pain in GWI Patients

Science.gov (United States)

2016-10-01

Chronic pain is not easily evaluated in mouse models, but we have noted behavioral and cognitive changes in mice following these exposures. Our...Crawford participated in a GWI symposium at the International Neuropsychological Society meeting in London in July 2016, organized by Dr. Kim Sullivan

Hâkim Seyyid Mehmed And His Book Called Nazire-i Hilye-i Hâkanî / HÂKİM SEYYİD MEHMED EFENDİ’NİN “NAZİRE-İ HİLYE-İ HÂKANΔ ADLI ESERİ

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Yakup POYRAZ (M.A.H.

2007-08-01

Full Text Available As a result of the deep divine love people had for our Prophet, various literarytypes such as mevlit and na’t appeared. Of these types, hilye is one of the morepopular ones. Hilyes describe our Prophet physically and morally and theyusually convey the divine love poets have for him. The best-known hilye inTurkish literature, Hilye-i Hâkanî, was written by Hâkanî Mehmet Bey in 16thcentury. One of the nazires written in this hilye belongs to Hâkim SeyyidMehmed who was an 8th century poet. This nazire is usually regarded as one ofthe best in Hilye-i Hâkanî. In this article investigated Hilye-i Hâkanî and madeuseful form to literature.

Kuula. Kuu artist Sam Sparro. Kuu plaat / Mart Juur

Index Scriptorium Estoniae

Juur, Mart, 1964-

2008-01-01

Artistist Sam Sparrost. Heliplaatidest: "Sex And The City" Original Motion Picture Soundtrack, "Maestro: Blue Note Trip", Melvin/Soo/Remmel/Julm "Geografix", Alanis Morrisette "Flavors Of Entanglement", Guillemots "Red"

Comparison of tadalafil pharmacokinetics after administration of a new orodispersible film versus a film-coated tablet

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Park SI

2018-04-01

Full Text Available Sang-In Park,1,* Su-Hak Heo,2,3,* Gihwan Kim,2 Seokhoon Chang,2 Keon-Hyoung Song,3 Min-Gul Kim,4 Eun-Heui Jin,5 JaeWoo Kim,5 SeungHwan Lee,1 Jang Hee Hong5,6 1Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Republic of Korea; 2R&D Center, C.L. Pharm Co., Ltd, Seoul, Republic of Korea; 3Department of Pharmaceutical Engineering, College of Medical Science, Soonchunhyang University, Asan, Republic of Korea; 4Department of Pharmacology, School of Medicine, Chonbuk National University, Jeonju, Republic of Korea; 5Clinical Trials Center, Chungnam National University Hospital, Daejeon, Republic of Korea; 6Department of Pharmacology, College of Medicine, Chungnam National University, Daejeon, Republic of Korea *These authors contributed equally to this work Background: An orodispersible film (ODF of tadalafil may provide increased convenience for erectile dysfunction (ED patients as compared to conventional tablet formulations. In this study, we aimed to compare the pharmacokinetic, safety, and tolerability profiles of a newly developed ODF formulation of tadalafil to those of a film-coated tablet (FCT of tadalafil.Materials and methods: This study was conducted in healthy male subjects using an open-label, randomized sequence, two-period, two-formulation, single-dose, crossover design. The subjects were randomly assigned to one of two sequences of the two formulations: both the test drug (ODF and the reference drug (FCT contained 20 mg of tadalafil. Blood samples were collected up to 72 h after administration. Plasma concentrations of tadalafil were analyzed using liquid chromatography–tandem mass spectrometry. Geometric mean ratios (GMRs of the ODF to FCT formulations and their 90% CIs for the pharmacokinetic parameters were estimated. Safety and tolerability were assessed throughout the study.Results: Forty healthy male subjects were enrolled, and 36 of these completed the

Prenatal development toxicity study of zinc oxide nanoparticles in rats

Directory of Open Access Journals (Sweden)

Hong JS

2014-12-01

Full Text Available Jeong-Sup Hong,1,2 Myeong-Kyu Park,1 Min-Seok Kim,1 Jeong-Hyeon Lim,1 Gil-Jong Park,1 Eun-Ho Maeng,1 Jae-Ho Shin,3 Meyoung-Kon Kim,4 Jayoung Jeong,5 Jin-A Park,2 Jong-Choon Kim,6 Ho-Chul Shin2 1Health Care Research Laboratory, Korea Testing and Research Institute, Gimpo, South Korea; 2College of Veterinary Medicine, Konkuk University, Seoul, South Korea; 3Department of Biomedical Laboratory Science, Eulji University, Seongnam-si, South Korea; 4Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea; 5Toxicological Research Division, National Institute of Food and Drug Safety Evaluation, Chungcheongbuk-do, South Korea; 6College of Veterinary Medicine, Chonnam National University, Gwangju, South Korea Abstract: This study investigated the potential adverse effects of zinc oxide nanoparticles ([ZnOSM20(+ NPs] zinc oxide nanoparticles, positively charged, 20 nm on pregnant dams and embryo–fetal development after maternal exposure over the period of gestational days 5–19 with Sprague-Dawley rats. ZnOSM20(+ NPs were administered to pregnant rats by gavage at 0, 100, 200, and 400 mg/kg/day. All dams were subjected to a cesarean section on gestational day 20, and all of the fetuses were examined for external, visceral, and skeletal alterations. Toxicity in the dams manifested as significantly decreased body weight after administration of 400 mg/kg/day NPs; reduced food consumption after administration of 200 and 400 mg/kg/day NPs; and decreased liver weight and increased adrenal glands weight after administration of 400 mg/kg/day NPs. However, no treatment-related difference in: number of corpora lutea; number of implantation sites; implantation rate (%; resorption; dead fetuses; litter size; fetal deaths and placental weights; and sex ratio were observed between the groups. On the other hand, significant decreases between treatment groups and controls were seen for fetal weights after

Keeping Kim; How the Kim Conundrum Best Serves American Interests in the Asia Pacific

Science.gov (United States)

2018-04-18

Bombs South Korea’s Yeonpyeong Island," The Telegraph, November 23. 2010. http://www.telegraph.co.uk/news/worldnews/asia...southkorea/8153000/North-Korea- bombs -South-Koreas- Yeonpyeong-Island.html (accessed 01/05/2017, 2017). 25 A key initiative during the Sunshine Policy was...tr ad in g pa rt ne r Sa m e et hn ic ity ; di ff er en t sy st em o f go ve rn an ce So ve re ig nt y iss ue s a lw ay s co ns id er ed

Gevalle van positiewe taalbeplanning soos gerapporteer in die ...

African Journals Online (AJOL)

Southern African Linguistics and Applied Language Studies ... Conversely, however, cases of positive language planning in respect of the languages ... generally and enthusiastically treated as part of a general policy, it would not have been ...

Kuidas tagada efektiivne riigi õigusabi kriminaalmenetluses? / Anneli Soo

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Soo, Anneli, 1984-

2014-01-01

Riigi vastutusest efektiivse kaitse õiguse rikkumise korral. Kohtulikust järelevalvest kaitsjate tegevuse üle kriminaalmenetluses. Efektiivse süsteemi väljatöötamisest riigi õigusabi andmiseks

Provenance and indirect dating study on Hongzhou Kiln porcelains by INAA

International Nuclear Information System (INIS)

Feng, X.Q.; Feng, S.L.; Fan, C.S.; Zhang, W.J.; Quan, K.S.

2005-01-01

Hongzhou Kiln is one of the six leading celadon kilns in Tang Dynasty and plays an important role in the history of Chinese ceramics for its diverse decoration styles and innovative technology. Archaeologists divided Hongzhou Kiln production into 8 periods, i.e. Eastern Han and Eastern Wu, Western Jin, Eastern Jin, Southern Dynasties, Sui, Early Tang, Middle Tang, Late Tang and Five Dynasties. Up to now, 26 kiln sites have been discovered and excavated. A study on the chemical composition of the porcelains of different periods and provenance will help to know the developing process of Hongzhou celadon such as variation of raw materials, recipes, manufacturing technology, causes of prosperity and decline, etc. Over 200 sherds were collected and their body samples were analyzed by INAA. The compositional differences between samples with the same period but different provenance were observed. The contents of Na, Rb, Ba, Fe, Th, U, etc were found to be different among samples from different periods, which implies they may be used to identify the manufacturing age. The analytical data were further processed by principal component analysis (PCA). The statistical results show that all the sherds can be classified into 5 groups, (1) Eastern Han and Eastern Wu; (2) Western Jin, Eastern Jin and Southern Dynasties; (3) Sui; (4) Early Tang and Middle Tang; (5) Late Tang and Five Dynasties.

Production and characterization of pectinases obtained from ...

African Journals Online (AJOL)

Production and characterization of pectinases obtained from Aspergillus fumigatus in submerged fermentation system using pectin extracted from mango peels as carbon source. AL Ezugwu, SOO Eze, FC Chilaka, CU Anyanwu ...

11 Resensie-artikel Stimie WEB 02.pmd

African Journals Online (AJOL)

Owner

Keywords: Afrikaans oratorio, classical music, corporate entertainment. .... soos FNB, Morning Star Express Hotel, kykNET, Packed House Productions, .... of feeling which represents the character of the people who speak that language.

Debora Vaarandi kodumaa / Maie Kalda

Index Scriptorium Estoniae

Kalda, Maie, 1929-2013

2007-01-01

Debora Vaarandi luulest: "Põleva laotuse linn", "Kohav rand", "Talgud Lööne soos", "Selgel hommikul", "Nii ma näen Eestimaad", "Unistaja aknal" ja "Rannalageda leib", "Eesti mullad". Ka Põhjamaa-teemast

AVA Muusika plaadistab loova mõtlemisega artiste

Index Scriptorium Estoniae

2004-01-01

AVA Muusika tegevusest eesti alternatiivse uue muusika salvestamisel, esimesest heliplaadist duo Erdmann/Sooäär Dessert Time'i ühisest albumist "Peer Gynt & Other Stories", plaadi esitlusest 5. nov. Berliinis

The Optimal Technological Development Path to Reduce Pollution and Restructure Iron and Steel Industry for Sustainable Transition

OpenAIRE

Ren, M.; Xu, X.; Ermolieva, T.; Cao, G.-Y.; Yermoliev, Y.

2018-01-01

China is the world’s largest iron and steel producer and Jing-Jin-Ji (Beijing-Tianjin-Hebei) region accounts for nearly 1/3 of the national iron and steel production, while it is facing serious air pollution. Among the top 10 worst polluted cities in China, seven were located in Hebei province in 2014. Recent years Jing-Jin-Ji region has been promoted iron & steel industry with green clean technology for accelerating sustainable economic transition. This paper tries to response the basic ques...

Eesti 15-16 aastaste koolinoorte uimastitarbimine : 1995., 1999. ja 2003. aasta uurimuste võrdlus / Airi-Alina Allaste

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Allaste, Airi-Alina, 1967-

2004-01-01

Rahvusvaheliste uurimuste ESPAD käigus koguti andmeid uimastite tarvitamisega seotud käitumise kohta koolinoorte hulgas; Joon.: uimastite tarvitamine soo ja õppekeele järgi, tubakaga katsetajad ja regulaarsed suitsetajad, kanepisuitsetajad

Download this PDF file

African Journals Online (AJOL)

2009-08-03

Aug 3, 2009 ... Leefwysesiektes soos obesiteit word verwaarloos in ontwikkelende lande weens die fokus op ..... the 25% attributable to infectious diseases (Bradshaw et al. .... UNESCO Institute for Statistics, 2008, Glossary: Pupil-teacher.

Hydrological influences on long-term gas flow trends at locations in the Vogtland/NW Bohemian seismic region (German-Czech border

Directory of Open Access Journals (Sweden)

J. Heinicke

2007-06-01

Full Text Available One of the typical methods for the identification of seismo-hydrological effects is to monitor changes in the free gas flow throughout springs or mofettes. For several years, the gas flow regime of mineral springs at Bad Brambach (Germany and mofettes in the Nature Park Soos (Czech Republic and its dependence on hydro-/meteorological parameters have been studied. The mineral spring ‘Wettinquelle’, Bad Brambach, is a well-known seismo- hydrologically sensitive location for swarmquakes at a special epicentral area of NW Bohemia. Since 2000, a slight upward trend in the gas flow of three Bad Brambach mineral springs has been observed, which became stronger after the ‘Eisenquelle’ spring capture reconstruction (winter 2003/2004. Similar behaviour could be detected at a mofette in Soos. The results correspond to a 3He/4He mantle ratio increase in gases at mofettes in the Cheb Basin (CZ traced by other authors for more than 12 years, and could give hints for a higher degassing activity of the magma body below that area. Common and special properties in the degassing regimes of the Bad Brambach and Soos locations are discussed. It is demonstrated that the long-term gas flow trend was interrupted in 2003 because of very low groundwater levels. This effect was amplified by the artificial groundwater lowering during the ‘Eisenquelle’ spring capture reconstruction.

Kim Davis: A Mother's Dilemma.

Science.gov (United States)

Hudecki, Michael S.

2000-01-01

Presents a discussion case in which parents must decide whether or not to enroll their sons in an experimental treatment program for muscular dystrophy. Identifies teaching objectives and discusses the key issues of the case--muscle structure and function, muscular dystrophy, scientists and money, scientific method and the FDA, and family health…

Traditsioonist ja uuendusest korea modernkunstis / Katrin Kivimaa

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Kivimaa, Katrin, 1969-

2005-01-01

Souli galeriides ja muuseumides valitseb eeldatud kõrgtehnoloogilise kunsti asemel maalikunst. Pikemalt naiskunstnik Wook-kyung Choi (1940-1985) ja Jong-gu Lee näitustest ning soo- ja naisuuringute kongressist "Women's World 2005"

Statistika = Statistics

Index Scriptorium Estoniae

2004-01-01

Andmeid maksuameti töötajate jagunemisest hariduse, soo, staazhi, vanuse järgi; koolitused 2001-2003, koolitusel osalejate arv; füüsilise isiku tuludeklaratsioon; tulu- ja sotsiaalmaksu maksudeklaratsioon; käibedeklaratsioon

Phillip Louw: Oxford Afrikaans-Engels / English-Afrikaans Skoolwoordeboek / School Dictionary

Directory of Open Access Journals (Sweden)

Anton F. Prinsloo

2011-10-01

Full Text Available Die Oxford Afrikaans–Engels/English–Afrikaans Skoolwoordeboek is as skoolwoor-deboek 'n puik hulpbron vir leerders. Dit is egter meer as net 'n woordeboek, soos wat 'n oorsig dadelik toon.

Plaadid / Kaur Garshnek, Ave Randviir, Priit Pruul...[jt.

Index Scriptorium Estoniae

2007-01-01

Uutest heliplaatidest Jaak Sooäär, Raul Vaigla, Tanel Ruben "No99 Jazzklubis", Black Strobe "Burn Your Own Church", The Quantic Soul Orchestra "Tropidelico", Uni "Kosmikud II", Bugge Wesseltoft "IM", Gabrielle "Always"

Blue Ocean Thinking

Science.gov (United States)

Orem, Donna

2016-01-01

This article describes a concept called the "blue ocean thinking strategy," developed by W. Chan Kim and Renée Mauborgne, professors at INSEAD, an international graduate school of business in France. The "blue ocean" thinking strategy considers opportunities to create new markets for services, rather than focusing solely on…

76 FR 27636 - Permits; Foreign Fishing

Science.gov (United States)

2011-05-12

...: Mi Ae Kim, Trade and Marine Stewardship Division, Office of International Affairs, NMFS, 1315 East... consisting solely of transporting fish or fish products at sea from a point within the United States Exclusive Economic Zone (EEZ) or, with the concurrence of a state, within the boundaries of that state to a...

International Physics Olympiad (24th) Held in Williamsburg, Virginia on July 10 - 18, 1993

Science.gov (United States)

1993-07-18

27.35 Bojan Gornik Slovenia 27.33 Yoo Chul Chung Korea 27.25 Andras Major Germany 27.05 Robert Kry Canada 27 Erik Larsson Sweden 27 lacopoCarusotto...Martin Canada: Kry, Robert China: Zhang, Junan Colombia: Massey, Ibrahim Croatia:. Garaj, Slaven Cuba: Campa, Erwin Portuondo Cyprus: Tofaris...2159 REPUBLIC OF KOREA Singapore Sooyong Kim Dept. of Physics Meng Hau Kuok Korea Advanced Inst. of Science & National University Technology of

Jiná avantgarda? Poznámky

Czech Academy of Sciences Publication Activity Database

Vojtěch, Daniel

Roč. 56, č. 5 ( 2008 ), s. 709-713 ISSN 0009-0468 Institutional research plan: CEZ:AV0Z90560517 Keywords : Czech literature * Avant-garde * modernism Subject RIV: AJ - Letters, Mass-media, Audiovision

Kritiese geletterdheid: Die ontmoeting tussen die Westerse sekularisme en Islamitiese spiritualiteit in geselekteerde romans vir jong volwasseness – 'n benadering

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Salome Romylos

2016-11-01

Full Text Available Hierdie artikel het ten doel om aan te toon dat die geselekteerde romans vir jong volwassenes potensieel kragtige ruimtes kan wees vir die skep van ’n bewustheid en beter begrip van Moslems, Islam, en veral van die dra van sluiers en kopdoeke. Kritiese geletterdheid as ’n metodologie word gebruik om te demonstreer hoe leerders gelei kan word om krities betrokke te raak by tekste. Dit is noodsaaklik, omdat blote oppervlakkennis nie genoeg is wanneer leerders gekonfronteer word met ingewikkelde kwessies soos ras, spiritualiteit en kultuur nie. Westerse televisie, koerante en tydskrifte skilder ’n baie eensydige beeld van Moslems as ’n naatloos homogene groep. Baie jong volwassenes neem aktief deel aan gesprekke op digitale media, soos Twitter en Facebook, waar kwessies van kultuur en diversiteit gereeld ter sprake kom. Westerlinge kan baie negatiewe persepsies van Islam en Moslems vorm wanneer hulle oorval word met ’n stortvloed beelde van gruwelikhede wat uitgevoer word deur ekstremistegroepe soos die Islamitiese Staat van Irak en die Ooste (ISIS. Die gevolg is dat alle Moslems gestereotipeer word as fundamentaliste, terroriste en onderdrukkers van vroue. Hierdie kenniskonstruk word gemanipuleer deur die media. ’n Begrip van die redes waarom vroue ’n stuk lap – die kopdoek – dra, kan ’n beginpunt wees vir die verandering van persepsies van Moslems en hul verskillende praktyke. Opvoeders moet oppas om nie net verdraagsaamheid tussen verskillende kulturele groepe te verkondig nie, want verdraagsaamheid impliseer ’n blote bestuur van ’n mens se gevoelens van afsku vir dit wat verdra word. Vrae wat uit ’n standpunt van kritiese geletterdheid gestel kan word aan tekste soos The breadwinner-trilogie deur Deborah Ellis en The girl in the tangerine scarf by Mohja Kahf, word bespreek as voorbeelde wat in die klaskamer gebruik kan word. Hierdie tekste beeld Moslemvroue en -meisies baie anders uit en kan vergelykend gelees word

A Study of China’s Possible Military Intervention in the Event of a Sudden Change in North Korea

Science.gov (United States)

2011-06-10

Kim Jong - nam , Kim Jong -chul or Kim Jong -un as Kim‘s successor. Some have asserted that there might not be a third generation of Kim ...The power struggle between Kim Jong - nam (eldest son) who is residing in China and Kim Jong -un has been observed in many places over time. Kim 29... Jong - nam , who is known to be receiving Chinese support, revealed his opposition to a third generation of dynastic succession in

Application of physiologically based pharmacokinetic modeling in predicting drug–drug interactions for sarpogrelate hydrochloride in humans

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Min JS

2016-09-01

Full Text Available Jee Sun Min,1 Doyun Kim,1 Jung Bae Park,1 Hyunjin Heo,1 Soo Hyeon Bae,2 Jae Hong Seo,1 Euichaul Oh,1 Soo Kyung Bae1 1Integrated Research Institute of Pharmaceutical Sciences, College of Pharmacy, The Catholic University of Korea, Bucheon, 2Department of Pharmacology, College of Medicine, The Catholic University of Korea, Seocho-gu, Seoul, South Korea Background: Evaluating the potential risk of metabolic drug–drug interactions (DDIs is clinically important. Objective: To develop a physiologically based pharmacokinetic (PBPK model for sarpogrelate hydrochloride and its active metabolite, (R,S-1-{2-[2-(3-methoxyphenylethyl]-phenoxy}-3-(dimethylamino-2-propanol (M-1, in order to predict DDIs between sarpogrelate and the clinically relevant cytochrome P450 (CYP 2D6 substrates, metoprolol, desipramine, dextromethorphan, imipramine, and tolterodine. Methods: The PBPK model was developed, incorporating the physicochemical and pharmacokinetic properties of sarpogrelate hydrochloride, and M-1 based on the findings from in vitro and in vivo studies. Subsequently, the model was verified by comparing the predicted concentration-time profiles and pharmacokinetic parameters of sarpogrelate and M-1 to the observed clinical data. Finally, the verified model was used to simulate clinical DDIs between sarpogrelate hydrochloride and sensitive CYP2D6 substrates. The predictive performance of the model was assessed by comparing predicted results to observed data after coadministering sarpogrelate hydrochloride and metoprolol. Results: The developed PBPK model accurately predicted sarpogrelate and M-1 plasma concentration profiles after single or multiple doses of sarpogrelate hydrochloride. The simulated ratios of area under the curve and maximum plasma concentration of metoprolol in the presence of sarpogrelate hydrochloride to baseline were in good agreement with the observed ratios. The predicted fold-increases in the area under the curve ratios of metoprolol

Functionally Graded Material: An overview

CSIR Research Space (South Africa)

Mahamood, RM

2012-07-01

Full Text Available -3146. [50] X. Jin, L. Wu, L. Guo, H. Yu, and Y. Sun, ?Experimental investigation of the mixed-mode crack propagation in ZrO2/NiCr functionally graded materials,? Engineering Fracture Mechanics, vol. 76(12), (2009), pp. 1800-1810. [51] Z. Cheng, D. Gao... by stable crack growth,? Engineering Fracture Mechanics, vol.72(15), (2005), pp. 2359-2372. [47] Z.-H. Jin, and R.H. Dodds Jr, ?Crack growth resistance behavior of a functionally graded material: computational studies,? Engineering Fracture Mechanics...

Värske kõrvaga kuuldud uuest Eesti muusikast / Elo Masing

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Masing, Elo

2011-01-01

Eksperimentaalset Eesti muusikat tutvustava heliplaadi "Estonian Music Now 2011 - Exploratory Music From Estonia" esitluskontserdist 31. oktoobril Londonis Cafe OTOs, kus esinesid duo Taavi Kerikmäe - Mart Soo, Taavo Remmel ning Free Tallinn Trio

Frees-jääksoode [looduslik] taimestumine / J. Paal, E. Leiner, T. Paal, T. Triisberg

Index Scriptorium Estoniae

2011-01-01

Lui looduslikus soos levivad paljud taimed eelkõige vegetatiivselt, siis jääksoos, eriti kui see ei piirne loodusliku sooga, seda toimuda ei saa, seega jääb seemneline uuendumine peamiselt tuulekandeliseks

Adapting a historical dictionary for the modern online user: The case ...

African Journals Online (AJOL)

user

accommodate new users and to bring the DSAEHist into the digital era (with regard to standard web and mobile ... digitale era. Soos met talle ander gedrukte woordeboeke wat omgeskakel word na elektroniese ...... marketing perspective.

Contribution to thermodynamics and kinetics of argon, krypton and xenon at very low temperatures; Contribution a l'etude thermodynamique et cinetique de l'argon, du krypton et du xenon aux tres basses temperatures

Energy Technology Data Exchange (ETDEWEB)

Levenson, L L [Commissariat a l' Energie Atomique, Saclay (France). Centre d' Etudes Nucleaires

1969-07-01

A critical analysis of the main theories of condensation, which are due to Zwanzig, Cabrera, Mc Caroll and Ehrlich, Wanlass, Armand, and Yu and Soo, is made. A condensation coefficient equal to unity is expected from these theories, except Armand and Yu and Soo, when the temperature of the gas impinging on its own solid phase is equal or less than 300 K. Using a resonating quartz microbalance the sensitivity of which is 10{sup -9} g. cm{sup 2} the experimental data agree with these theories when the temperature of the solid is less than 20 K. However the agreement must be interpreted for the more sophisticated theories of Armand and Yu and Soo. Regarding the sublimation of the rare gases one is faced with the theories of Salter, Eyring, Goodman and Armand. Within an order of magnitude the experimental data given here agree with the expected values. Moreover Armand theory is able to give the physical meaning of the observed results for argon sublimation from a krypton or a xenon crystalline substrate: localized modes of surface vibration occur. The relaxation time for the thermalization of the argon deposit is found greater than twelve hours at 25 K. (author) [French] Ce travail inclut l'etude critique des principales theories de la condensation dues a Zwanzig, Cabrera, Mc Caroll et Ehrlich, Wanlass, Armand, et Yu et Soo. Ces theories, sauf les deux dernieres, prevoient un coefficient de condensation egal a 1 lorsque le gaz incident sur son propre solide a une temperature inferieure ou egale a 300 K. Les mesures effectuees a l'aide d'une microbalance a quarz resonnant sensible a 10{sup -9} g. cm{sup 2} ont confirme ces theories dans le cas ou la temperature du solide est inferieure a 20 K. Cet accord doit cependant etre interprete pour les theories plus completes d'Armand d'une part, Yu et Soo d'autre part. Pour la sublimation des gaz rares on se trouve en presence des theories de Salter, Eyring, Goodman et Armand. Leurs previsions sont en accord, a un ordre de

International Conference on Composite Structures (7th), Held in United Kingdom, July 1993. Volume 25, Numbers 1 - 4

Science.gov (United States)

1993-07-01

McGravk-Hlill. Now York. Chaptcr 4. 1975. SM thesis. Departmcnt of Aeronautics and Astro - 10, Lee, 1). 6i., Kim. K. S. & In. Y. T.. An experimental nautics...platte stiffness, where fied analte, sical ,lyuigathe fxc -initte l alm nt Netin thle maimumIILII energy dissipation results inl a large’ systeml damping

Vintage: suvaline eriline vastikult eklektiline rohujuure disain = Vintage: arbitrary and peculiar, obnoxiously eclectic grassroots design / Karin Paulus

Index Scriptorium Estoniae

Paulus, Karin, 1975-

2013-01-01

Sisearhitekt Priit Põldme vintage stiilist. Armastusväärse kujundusega kohvikutest Eestis. Pikemalt kohvikust "Boheem" (Kopli t. 18, sisearhitekt Maris Kerge), "Kukeke" (Telliskivi t.), baarist "Pudel" (Telliskivi loomelinnak, sisekujundus: Pink) ja "Tops" (Soo t.) Tallinnas

pastorale begeleiding van die emosioneel verwonde tiener

African Journals Online (AJOL)

1 Met emosionele verwonding word verwys na die gevolge van aspekte soos verwerping ..... gevind dat getraumatiseerde kinders geneig is om hul onverwerkte trauma ..... The changing face of the South African family: single moms now the.

Yerli ve Yabancı Kökenli Bazı Zeytinyağlarının Trigliserit Düzeylerine Göre Kemometrik Sınıflandırılması

Directory of Open Access Journals (Sweden)

Harun Dıraman

2015-02-01

Full Text Available Bu çalışmada Türkiye’den (2 KKTC, 2 Güneydoğu Anadolu, 3 Akdeniz, 9 Kuzey Ege, 3 İzmir Yarımdası, 16 Güney Ege, 11 Akhisar-Manisa, 4 Marmara ve diğer ülkelerden (1 Ürdün, 1 Filistin, 3 İspanya,1 Portekiz, 2 İtalya, 2 Yunanistan olmak üzere toplam 60 adet ticari natürel zeytinyağı örneği, kemometrik yöntemler (Temel Bileşenler [PCA] Kümeleme [HCA] analizleri yardımıyla triaçilgliserol (TAG bileşenlerine göre sınıflandırılmış ve karakterize edilmişlerdir. Yağ örneklerinin TAG profilleri (ECN 42–ECN 50,LLL ve ana bileşenleri LOO, OOO, POO, PLO ve SOO Avrupa Komisyonu (ABK tarafından onaylanmış Yüksek Basınç Sıvı Kromatografisi ile belirlenmiştir. Türk natürel zeytinyağlarının TAG bileşenlerinin diğer zeytinyağı üreten ülkelerin ürünleri ile benzer olduğu ve bir örnek hariç (Filistin analiz edilen tüm yağ örneklerindeki trilinolein (LLL düzeylerinin, ABK tarafından farklı zeytinyağları için verilen en çok %0.5 düzeyini aşmadığı görülmüştür. Kümeleme analizi (HCA sonuçlarına göre, Türk ve yabancı zeytinyağı örnekleri sırasıyla beş gruba ayrılmıştır. Temel bileşenler analizine (PCA göre, Güney Ege (hâkim çeşit Memecik yağ örneklerinin sınıflandırılmasında LOO/POO, OOO/POO ve OOO düzeylerinin sorumlu olduğu gözlenmiştir. Kuzey Ege (hâkim çeşit Ayvalık örneklerinin ayrımında LOO parametresi büyük rol oynamıştır. Akhisar–Manisa yöresi örnekleri ise ECN48 ve ECN48/ECN46 parametreleri ile karakterize olmuştur. Bu çalışmada Türkiye’den (2 KKTC, 2 Güneydoğu Anadolu, 3 Akdeniz, 9 Kuzey Ege, 3 İzmir Yarımdası, 16 Güney Ege, 11 Akhisar-Manisa, 4 Marmara ve diğer ülkelerden (1 Ürdün, 1 Filistin, 3 İspanya,1 Portekiz, 2 İtalya, 2 Yunanistan olmak üzere toplam 60 adet ticari natürel zeytinyağı örneği, kemometrik yöntemler (Temel Bileşenler [PCA] Kümeleme [HCA] analizleri yardımıyla tria

Source data supported high resolution carbon emissions inventory for urban areas of the Beijing-Tianjin-Hebei region: Spatial patterns, decomposition and policy implications.

Science.gov (United States)

Cai, Bofeng; Li, Wanxin; Dhakal, Shobhakar; Wang, Jianghao

2018-01-15

This paper developed internationally compatible methods for delineating boundaries of urban areas in China. By integrating emission source data with existing official statistics as well as using rescaling methodology of data mapping for 1 km grid, the authors constructed high resolution emission gridded data in Beijing-Tianjin-Hebei (Jing-Jin-Ji) region in China for 2012. Comparisons between urban and non-urban areas of carbon emissions from industry, agriculture, household and transport exhibited regional disparities as well as sectoral differences. Except for the Hebei province, per capita total direct carbon emissions from urban extents in Beijing and Tianjin were both lower than provincial averages, indicating the climate benefit of urbanization, comparable to results from developed countries. Urban extents in the Hebei province were mainly industrial centers while those in Beijing and Tianjin were more service oriented. Further decomposition analysis revealed population to be a common major driver for increased carbon emissions but climate implications of urban design, economic productivity of land use, and carbon intensity of GDP were both cluster- and sector-specific. This study disapproves the one-size-fits-all solution for carbon mitigation but calls for down-scaled analysis of carbon emissions and formulation of localized carbon reduction strategies in the Jing-Jin-Ji as well as other regions in China. Copyright © 2017 Elsevier Ltd. All rights reserved.

A genetic screen of the mutations in the Korean patients with early-onset Alzheimer’s disease

Directory of Open Access Journals (Sweden)

An SS

2016-12-01

Full Text Available Seong Soo An,1,* Sun Ah Park,2,* Eva Bagyinszky,1 Sun Oh Bae,1 Yoon-Jeong Kim,2 Ji Young Im,2 Kyung Won Park,3 Kee Hyung Park,4 Eun-Joo Kim,5 Jee Hyang Jeong,6 Jong Hun Kim,7 Hyun Jeong Han,8 Seong Hye Choi,9 SangYun Kim10 1Department of Bionano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Dong-A University College of Medicine and Institute of Convergence Bio-Health, Busan, 4Department of Neurology, Gachon University Gil Medical Center, Incheon, 5Department of Neurology, Pusan National University Hospital, Busan, 6Department of Neurology, Ewha Womans University Mokdong Hospital, Seoul, 7Department of Neurology, Ilsan Hospital, National Health Insurance Corporation, 8Department of Neurology, Myongii Hospital, Goyang, 9Department of Neurology, Inha University School of Medicine, Incheon, 10Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: Early-onset Alzheimer’s disease (EOAD has distinct clinical characteristics in comparison to late-onset Alzheimer’s disease (LOAD. The genetic contribution is suggested to be more potent in EOAD. However, the frequency of causative mutations in EOAD could be variable depending on studies. Moreover, no mutation screening study has been performed yet employing large population in Korea. Previously, we reported that the rate of family history of dementia in EOAD patients was 18.7% in a nationwide hospital-based cohort study, the Clinical Research Center for Dementia of South Korea (CREDOS study. This rate is much lower than in other countries and is even comparable to the frequency of LOAD patients in our country. To understand the genetic characteristics of EOAD in Korea, we screened the common Alzheimer’s disease (AD

Investor Laaril esimene miljon teenitud / Kertu Ruus, Raivo Sormunen

Index Scriptorium Estoniae

Ruus, Kertu, 1977-

2007-01-01

Mart Laar, Imre Sooäär ja Kristen Michal oma aktsiaportfellist ja investeerimisstrateegiast. Edetabel: Riigikogus kolm miljonärist väikeinvestorit. Tabel: Ekspeaminister Laar on investeerinud erinevatesse piirkondadesse. Kommenteerivad Peeter Luikmel ja Pertti Rahnel

Eksperiment - teeme kõige noorema Vanemuise näitleja vanaemaks

Index Scriptorium Estoniae

2010-01-01

Vanemuise teatri noorim näitleja Liisa Pulk osaleb Anne-Ly Soo (grimmiala juht) ja Erle Vannuse (jumestuskunstnik) lavagrimmi eksperimendis. Artiklis teatrigrimeerija tööst lähemalt. Lisaks näitleja CV: "Liisa Pulk"

The Napoleon Graves / Michael Tarm

Index Scriptorium Estoniae

Tarm, Michael

2002-01-01

Vilniuse lähedal leiti 1812. a. Isamaasõjas hukkunud prantsuse sõdurite matmispaik. Säilmete antropoloogilised uuringud võimaldavad kindlaks määrata hukkunute vanuse, soo ja tõenäolise surma põhjuse

Pandi ja Hanschmidti spaa sai EASilt 10 miljonit krooni / Ralf-Martin Soe

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Soe, Ralf-Martin

2007-01-01

Ettevõtluse Arendamise Sihtasutus finantseeris 2006. aastal 10 miljoni krooniga Tallinki juhtfiguuride osalusega AS-i Heal uue spaa ehitust Haapsalus. Diagramm: Osalused AS-is Heal. Vt. samas: Kilgile ja Sooäärele samuti 10 miljonit

Dissecting and Targeting Latent Metastasis

Science.gov (United States)

2014-09-01

Option in Brain Metastasis Manuel Valiente,1 Anna C. Obenauf,1 Xin Jin,1 Qing Chen,1 Xiang H.-F. Zhang,1,8 Derek J. Lee,1 Jamie E. Chaft,2 Mark G. Kris,2...of poor response to tamoxifen therapy in recurrent breast cancer. J. Natl. Cancer Inst. 87, 751–756. Francia, G., Cruz -Munoz, W., Man, S., Xu, P... Manuel Valiente1, Xin Jin1†, Ekrem Emrah Er1, Ruzeen Patwa1, Ke Xu3 and Joan Massagué1 1 Cancer Biology and Genetics Program, 2 Department of

Atomic carbon chains as spin-transmitters: An ab initio transport study

DEFF Research Database (Denmark)

Fürst, Joachim Alexander; Brandbyge, Mads; Jauho, Antti-Pekka

2010-01-01

An atomic carbon chain joining two graphene flakes was recently realized in a ground-breaking experiment by Jin et al. (Phys. Rev. Lett., 102 (2009) 205501). We present ab initio results for the electron transport properties of such chains and demonstrate complete spin-polarization of the transmi......An atomic carbon chain joining two graphene flakes was recently realized in a ground-breaking experiment by Jin et al. (Phys. Rev. Lett., 102 (2009) 205501). We present ab initio results for the electron transport properties of such chains and demonstrate complete spin...

Pyongyangi leedi Macbeth tõmbab niite Põhja-Koreas / Yuriko Koike

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Koike, Yuriko

2010-01-01

Põhja-Korea liidri Kim Jong-il'i õest Kim Kyong-hui'st. Autori, Jaapani endise kaitseministri väitel on hakatud uskuma, et Kim Jong-il võib igal hetkel määrata just Kim Kyong-hui üleminekuaja valitsejaks, kes peab korraldama tema surma järel kolmanda põlvkonna Kimi võimuletuleku, kuid Kim Kyong-hui võib ise ihata saada Kim Jong-ili mantlipärijaks

Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy

Directory of Open Access Journals (Sweden)

Gurunathan S

2015-10-01

Full Text Available Sangiliyandi Gurunathan, Jae Woong Han, Jung Hyun Park, Eunsu Kim, Yun-Jung Choi, Deug-Nam Kwon, Jin-Hoi Kim Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea Background: Graphene and graphene-based nanocomposites are used in various research areas including sensing, energy storage, and catalysis. The mechanical, thermal, electrical, and biological properties render graphene-based nanocomposites of metallic nanoparticles useful for several biomedical applications. Epithelial ovarian carcinoma is the fifth most deadly cancer in women; most tumors initially respond to chemotherapy, but eventually acquire chemoresistance. Consequently, the development of novel molecules for cancer therapy is essential. This study was designed to develop a simple, non-toxic, environmentally friendly method for the synthesis of reduced graphene oxide–silver (rGO–Ag nanoparticle nanocomposites using Tilia amurensis plant extracts as reducing and stabilizing agents. The anticancer properties of rGO–Ag were evaluated in ovarian cancer cells. Methods: The synthesized rGO–Ag nanocomposite was characterized using various analytical techniques. The anticancer properties of the rGO–Ag nanocomposite were evaluated using a series of assays such as cell viability, lactate dehydrogenase leakage, reactive oxygen species generation, cellular levels of malonaldehyde and glutathione, caspase-3 activity, and DNA fragmentation in ovarian cancer cells (A2780. Results: AgNPs with an average size of 20 nm were uniformly dispersed on graphene sheets. The data obtained from the biochemical assays indicate that the rGO–Ag nanocomposite significantly inhibited cell viability in A2780 ovarian cancer cells and increased lactate dehydrogenase leakage, reactive oxygen species generation, caspase-3 activity, and DNA fragmentation compared with other tested nanomaterials such as graphene oxide, rGO, and AgNPs. Conclusion: T. amurensis plant extract

Hyaluronan-conjugated liposomes encapsulating gemcitabine for breast cancer stem cells

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Han NK

2016-04-01

Full Text Available Na-Kyung Han,1,* Dae Hwan Shin,1,* Jung Seok Kim,1 Kwon Yeon Weon,2 Chang-Young Jang,1 Jin-Seok Kim1 1Research Center for Cell Fate Control (RCCFC and College of Pharmacy, Sookmyung Women’s University, Seoul, 2College of Pharmacy, Catholic University of Daegu, Gyeongbuk, Korea *These authors contributed equally to this work Abstract: Investigation of potential therapeutics for targeting breast cancer stem cells (BCSCs is important because these cells are regarded as culprit of breast cancer relapse. Accomplishing this kind of strategy requires a specific drug-delivery system using the distinct features of liposomes. Studies on targeted liposomal delivery systems have indicated the conjugation of hyaluronan (HA, a primary ligand for CD44 surface markers, as an appropriate method for targeting BCSCs. For this study, enriched BCSCs were obtained by culturing MCF-7 breast cancer cells in nonadherent conditions. The enriched BCSCs were challenged with HA-conjugated liposomes encapsulating gemcitabine (2, 2-difluoro-2-deoxycytidine, GEM. In vitro study showed that the HA-conjugated liposomes significantly enhanced the cytotoxicity, anti-migration, and anti-colony formation abilities of GEM through targeting of CD44 expressed on BCSCs. In pharmacokinetic study, area under the drug concentration vs time curve (AUC of the immunoliposomal GEM was 3.5 times higher than that of free GEM, indicating that the HA-conjugated liposomes enhanced the stability of GEM in the bloodstream and therefore prolonged its half-life time. The antitumor effect of the immunoliposomal GEM was 3.3 times higher than that of free GEM in a xenograft mouse model, probably reflecting the unique targeting of the CD44 receptor by HA and the increased cytotoxicity and stability through the liposomal formulation. Furthermore, marginal change in body weight demonstrated that the use of liposomes considerably reduced the systemic toxicity of GEM on normal healthy cells. Taken together

Identification of a cell-penetrating peptide domain from human beta-defensin 3 and characterization of its anti-inflammatory activity

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Lee JY

2015-08-01

Full Text Available Jue Yeon Lee,1,* Jin Sook Suh,2,* Jung Min Kim,1 Jeong Hwa Kim,1 Hyun Jung Park,1 Yoon Jeong Park,1,2 Chong Pyoung Chung1 1Central Research Institute, Nano Intelligent Biomedical Engineering Corporation (NIBEC, Chungcheongbuk-do, Republic of Korea; 2Dental Regenerative Biotechnology, Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea *These authors contributed equally to this work Abstract: Human beta-defensins (hBDs are crucial factors of intrinsic immunity that function in the immunologic response to a variety of invading enveloped viruses, bacteria, and fungi. hBDs can cause membrane depolarization and cell lysis due to their highly cationic nature. These molecules participate in antimicrobial defenses and the control of adaptive and innate immunity in every mammalian species and are produced by various cell types. The C-terminal 15-mer peptide within hBD3, designated as hBD3-3, was selected for study due to its cell- and skin-penetrating activity, which can induce anti-inflammatory activity in lipopolysaccharide-treated RAW 264.7 macrophages. hBD3-3 penetrated both the outer membrane of the cells and mouse skin within a short treatment period. Two other peptide fragments showed poorer penetration activity compared to hBD3-3. hBD3-3 inhibited the lipopolysaccharide-induced production of inducible nitric oxide synthase, nitric oxide, and secretory cytokines, such as interleukin-6 and tumor necrosis factor in a concentration-dependent manner. Moreover, hBD3-3 reduced the interstitial infiltration of polymorphonuclear leukocytes in a lung inflammation model. Further investigation also revealed that hBD3-3 downregulated nuclear factor kappa B-dependent inflammation by directly suppressing the degradation of phosphorylated-IκBα and by downregulating active nuclear factor kappa B p65. Our findings indicate that hBD3-3 may be conjugated with drugs of interest to ensure their proper translocation to

Reduction of graphene oxide by resveratrol: a novel and simple biological method for the synthesis of an effective anticancer nanotherapeutic molecule

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Gurunathan S

2015-04-01

Full Text Available Sangiliyandi Gurunathan, Jae Woong Han, Eun Su Kim, Jung Hyun Park, Jin-Hoi Kim Department of Animal Biotechnology, Konkuk University, Seoul, Republic of Korea Objective: Graphene represents a monolayer or a few layers of sp2-bonded carbon atoms with a honeycomb lattice structure. Unique physical, chemical, and biological properties of graphene have attracted great interest in various fields including electronics, energy, material industry, and medicine, where it is used for tissue engineering and scaffolding, drug delivery, and as an antibacterial and anticancer agent. However, graphene cytotoxicity for ovarian cancer cells is still not fully investigated. The objective of this study was to synthesize graphene using a natural polyphenol compound resveratrol and to investigate its toxicity for ovarian cancer cells.Methods: The successful reduction of graphene oxide (GO to graphene was confirmed by UV-vis and Fourier transform infrared spectroscopy. Dynamic light scattering and scanning electron microscopy were employed to evaluate particle size and surface morphology of GO and resveratrol-reduced GO (RES-rGO. Raman spectroscopy was used to determine the removal of oxygen-containing functional groups from GO surface and to ensure the formation of graphene. We also performed a comprehensive analysis of GO and RES-rGO cytotoxicity by examining the morphology, viability, membrane integrity, activation of caspase-3, apoptosis, and alkaline phosphatase activity of ovarian cancer cells.Results: The results also show that resveratrol effectively reduced GO to graphene and the properties of RES-rGO nanosheets were comparable to those of chemically reduced graphene. Biological experiments showed that GO and RES-rGO caused a dose-dependent membrane leakage and oxidative stress in cancer cells, and reduced their viability via apoptosis confirmed by the upregulation of apoptosis executioner caspase-3.Conclusion: Our data demonstrate a single, simple green

Urine Kidney Injury Molecule-1: A Potential Non-invasive Biomarker for Patients with Renal Cell Carcinoma

Science.gov (United States)

Zhang, Ping L.; Mashni, Joseph W.; Sabbisetti, Venkata S.; Schworer, Charles M.; Wilson, George D.; Wolforth, Stacy C.; Kernen, Kenneth M.; Seifman, Brian D.; Amin, Mitual B.; Geddes, Timothy J.; Lin, Fan; Bonventre, Joseph V.; Hafron, Jason M.

2014-01-01

Objective To evaluate the use of urine KIM-1 as a biomarker for supporting a diagnosis of kidney cancers before operation. Methods A total of 19 patients were enrolled in the study based on preoperative imaging studies. Pre-operative and follow-up (1 month) uKIM-1 levels were measured and normalized with uCr levels and renal tumors were stained for KIM-1 using immunohistochemical techniques. Results The percentage of KIM-1 positive staining RCC cells ranged from 10 to 100% and the staining intensity ranged from 1+ to 3+. Based on the KIM-1 staining, 19 cases were divided into the KIM-1-negative staining group (n =7) and the KIM-1-positive group (n = 12). Serum creatinine (sCR) levels were significantly elevated after nephrectomy in both groups. In the KIM-1 negative group, uKIM-1/uCr remained at a similar level before (0.37 ± 0.1 ng/mg Cr) and after nephrectomy (0.32 ± 0.01 ng/mg Cr). However, in the KIM-1 positive group, elevated uKIM-1/uCr at 1.20 ± 0.31 ng/mg Cr was significantly reduced to 0.36± 0.1 ng/mg Cr, which was similar to the pre-operative uKIM-1/uCr (0.37 ± 0.1 ng/mg Cr) in the KIM-1 negative group. Conclusion Our study showed significant reduction in uKIM-1/uCr after nephrectomy, suggesting that urine KIM-1 may serve as a surrogate biomarker for kidney cancer and a non-invasive pre-operative measure to evaluate the malignant potential of renal masses. PMID:23979814

Transcriptome analysis and ultrastructure observation reveal that hawthorn fruit softening is due to cellulose/hemicellulose degradation

Directory of Open Access Journals (Sweden)

Jiayu Xu

2016-10-01

Full Text Available Softening, a common phenomenon in many fruits, is a well coordinated and genetically determined process. However, the process of flesh softening during ripening has rarely been described in hawthorn. In this study, we found that ‘Ruanrou Shanlihong 3 Hao’ fruits became softer during ripening, whereas ‘Qiu JinXing’ fruits remained hard. At late developmental stages, the firmness of ‘Ruanrou Shanlihong 3 Hao’ fruits rapidly declined, and that of ‘Qiu JinXing’ fruits remained essentially unchanged. According to transmission electron microscopy (TEM, the middle lamella of ‘Qiu JinXing’ and ‘Ruanrou Shanlihong 3 Hao’ fruit flesh was largely degraded as the fruits matured. Microfilaments in ‘Qiu JinXing’ flesh were arranged close together and were deep in color, whereas those in ‘Ruanrou Shanlihong 3 Hao’ fruit flesh were arranged loosely, partially degraded and light in color. RNA-Seq analysis yielded approximately 46.72 Gb of clean data and 72,837 unigenes. Galactose metabolism and pentose and glucuronate interconversions are involved in cell wall metabolism, play an important role in hawthorn texture. We identified 85 unigenes related to the cell wall between hard- and soft-fleshed hawthorn fruits. Based on data analysis and real-time PCR, we suggest that β-GAL and PE4 have important functions in early fruit softening. The genes Ffase, Gns, α-GAL, PE63, XTH and CWP, which are involved in cell wall degradation, are responsible for the different textures of hawthorn fruits. Thus, we hypothesize that the different textures of ‘Qiu JinXing’ and ‘Ruanrou Shanlihong 3 Hao’ fruits at maturity mainly result from cellulose/hemicelluloses degradation rather than from lamella degradation. Overall, we propose that different types of hydrolytic enzymes in cells interact to degrade the cell wall, resulting in ultramicroscopic Structure changes in the cell wall and, consequently, fruit softening. These results provide

Plaadid / Kaur Garshnek, Mart Niineste, Tui Hirv...[jt.

Index Scriptorium Estoniae

2008-01-01

Uutest heliplaatidest Tuule Kann/Jaak Sooäär "Õhtu ilu", The Mars Volta "The Bedlam In Goliath", Eva Dahlgren "Petroleum Och Tang", Lenny Kravitz "It's Time For A Love revolution", "Flyleaf ", New Project "Ultraviolent Light"

50 CFR 226.212 - Critical habitat for 13 Evolutionarily Significant Units (ESUs) of salmon and steelhead...

Science.gov (United States)

2010-10-01

...); Green River (47.2911, -121.9714); Jenkins Creek (47.3791, -122.0899); Little Soos Creek (47.4031, -122...) upstream to endpoint(s) in: Henry Creek (45.3328, -121.9110); Still Creek (45.2755, -121.8413); Unnamed (45...

Current status of the East Sea Ecosystem in a changing world

Science.gov (United States)

Lee, Sang Heon; Kang, Chang-Keun; Lee, Chung IL; Kwak, Jung Hyun

2017-12-01

The East/Japan Sea (hereafter the East Sea) is changing quickly. Warming and structural changes in the East Sea have been reported by CREAMS, an acronym of ″Circulation Research of the East Asian Marginal Seas″, which began in 1993 as an international research program to understand the water mass structure and circulation in the East Sea (Kim and Kim, 1996; Kim, 1997; Kim et al., 2001, 2002). A subsequent research program of the EAST-I, an acronym of ″the East Asian Seas Time-series″, was launched by PICES (North Pacific Marine Science Organization) and financially supported by the Korean government, allowing us to deepen our knowledge about rapidly changing processes in the East Sea (Chang et al., 2010). Although there has been considerable progress in developing a mechanistic understanding of the East Sea ecosystem responses to disturbances, more comprehensive studies are needed to address the impacts of the frequency and intensity of disturbances on marine ecosystems. The most important question of the research has been: how do environmental changes affect structural and functional biodiversity? Recently launched research on ″Long-term change of structure and function in marine ecosystems of Korea″, which has been supported by the Korean government since 2011, has given an unprecedented insight into the ecosystem dynamics in the East Sea. It therefore seems an appropriate time to devote a special issue to the topic of ″Current status of the East Sea ecosystem in a changing world″.

Muusikalised jutustused

Index Scriptorium Estoniae

2008-01-01

Üritustest kontsertsarja Soul Spectrum raames Kumus: 14. märstsil Ursula Rucker (soojendusesinejad Riho Sibul, Jaak Sooäär ja Raul Saaremets), 15. märtsil folk-jazzlaulja Terry Callier (soojendusesinejad Tõnis Mägi ja Chalice)

Active aging through employment: a critical feminist perspective on Polish policy / Ania Zbyszewska

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Zbyszewska, Ania

2016-01-01

Aktiivsest vananemisest, vanemaealiste tööhõivest. Üle 50-aastaste töötajate positsioonist tööjõuturul, soo ja teiste sotsiaalsete faktorite mõjust sellele. Poola aktiivse vananemise poliitikatest viimase 20 aasta jooksul

Eestimaa turismitöökoda MATKAMIKS 2004

Index Scriptorium Estoniae

2004-01-01

Turismiseminarist "Kultuur turismis. Turism kultuuris", kus turismist ja kultuurist rääkisid Riigikogu liige Imre Sooäär, EHRL juhatuse esimees Tarmo Sumberg, ajaloolane Lauri Vahtre, lavastaja Katri Kaasik-Aaslav ning Viljandi Kultuuriakadeemia rektor Anzori Barkalaja

CrossTalk: The Journal of Defense Software Engineering. Volume 21, Number 12

Science.gov (United States)

2008-12-01

IACROs Competitive Non- Competitive BAA: Broad Agency Announcement IACRO: Inter-Agency Cost Reimbursement Order MIPR: Military Interdepartmental...IACRO: Inter-Agency Cost Reimbur ement Order MIPR: Military Interdepartmental Purchas Request PWS: Performance Work Statement SOO: Stateme t of Objectives

Kas sugu on läbirääkimistel tähtis

Index Scriptorium Estoniae

2006-01-01

Ülevaade Harvard Business Schooli uudiskirja Working Knowledge 2006. aasta veebruari numbris ilmunud Dina W. Pradel'i, Hannah Riley Bowles'i ja Kathleen L. McGinn'i artiklist inimese soo mõjust läbirääkimistele

The Senses of Agency and Ownership: A Review.

Science.gov (United States)

Braun, Niclas; Debener, Stefan; Spychala, Nadine; Bongartz, Edith; Sörös, Peter; Müller, Helge H O; Philipsen, Alexandra

2018-01-01

Usually, we do not question that we possess a body and act upon the world. This pre-reflective awareness of being a bodily and agentive self can, however, be disrupted by different clinical conditions. Whereas sense of ownership (SoO) describes the feeling of mineness toward one's own body parts, feelings or thoughts, sense of agency (SoA) refers to the experience of initiating and controlling an action. Although SoA and SoO naturally coincide, both experiences can also be made in isolation. By using many different experimental paradigms, both experiences have been extensively studied over the last years. This review introduces both concepts, with a special focus also onto their interplay. First, current experimental paradigms, results and neurocognitive theories about both concepts will be presented and then their clinical and therapeutic relevance is discussed.

Improved oral absorption of cilostazol via sulfonate salt formation with mesylate and besylate

Directory of Open Access Journals (Sweden)

Seo JH

2015-07-01

Full Text Available Jae Hong Seo, Jung Bae Park, Woong-Kee Choi, Sunhwa Park, Yun Jin Sung, Euichaul Oh, Soo Kyung Bae College of Pharmacy and Integrated Research Institute of Pharmaceutical Sciences, The Catholic University of Korea, Bucheon, South Korea Objective: Cilostazol is a Biopharmaceutical Classification System class II drug with low solubility and high permeability, so its oral absorption is variable and incomplete. The aim of this study was to prepare two sulfonate salts of cilostazol to increase the dissolution and hence the oral bioavailability of cilostazol.Methods: Cilostazol mesylate and cilostazol besylate were synthesized from cilostazol by acid addition reaction with methane sulfonic acid and benzene sulfonic acid, respectively. The salt preparations were characterized by nuclear magnetic resonance spectroscopy. The water contents, hygroscopicity, stress stability, and photostability of the two cilostazol salts were also determined. The dissolution profiles in various pH conditions and pharmacokinetic studies in rats were compared with those of cilostazol-free base.Results: The two cilostazol salts exhibited good physicochemical properties, such as nonhygroscopicity, stress stability, and photostability, which make it suitable for the preparation of pharmaceutical formulations. Both cilostazol mesylate and cilostazol besylate showed significantly improved dissolution rate and extent of drug release in the pH range 1.2–6.8 compared to the cilostazol-free base. In addition, after oral administration to rats, cilostazol mesylate and cilostazol besylate showed increases in Cmax and AUCt of approximately 3.65- and 2.87-fold and 3.88- and 2.94-fold, respectively, compared to cilostazol-free base.Conclusion: This study showed that two novel salts of cilostazol, such as cilostazol mesylate and cilostazol besylate, could be used to enhance its oral absorption. The findings warrant further preclinical and clinical studies on cilostazol mesylate and

DNA-based approaches to identify forest fungi in Pacific Islands: A pilot study

Science.gov (United States)

Anna E. Case; Sara M. Ashiglar; Phil G. Cannon; Ernesto P. Militante; Edwin R. Tadiosa; Mutya Quintos-Manalo; Nelson M. Pampolina; John W. Hanna; Fred E. Brooks; Amy L. Ross-Davis; Mee-Sook Kim; Ned B. Klopfenstein

2013-01-01

DNA-based diagnostics have been successfully used to characterize diverse forest fungi (e.g., Hoff et al. 2004, Kim et al. 2006, Glaeser & Lindner 2011). DNA sequencing of the internal transcribed spacer (ITS) and large subunit (LSU) regions of nuclear ribosomal DNA (rDNA) has proved especially useful (Sonnenberg et al. 2007, Seifert 2009, Schoch et al. 2012) for...

'n Godsleer van Openbaring soos vervat in die himnes

Directory of Open Access Journals (Sweden)

E. Meyer

1997-07-01

Full Text Available A Theology of Revelations as imbedded in the hymns. This anicle is based on a twofold hypothesis, namely that the author of Revelation not only wrote the hymns in this book,' he also used them specifically to express his theology. The narrator utilises the hymnes to lay words in the mouths of the characters in order to establish a complete theology as well as christology. These hymns can even be used today to offer mankind real hope by calling one and all to the centre and true reason for our existence: Worship God!

Kutseõppeasutuste õpetajad = Pedagogues of vocational education institutions / Tiiu-Liisa Rummo

Index Scriptorium Estoniae

Rummo, Tiiu-Liisa

2007-01-01

Eesti lähituleviku eesmärgiks on motiveerida kutsehariduse pedagooge ja spetsialiste kutseharidussüsteemis töötama. Kutseõppeasutuste pedagoogid vanuserühma, soo, ametijärgu ja haridusastme järgi. Lisatud diagramm ja tabelid

Plaadiesitlus

Index Scriptorium Estoniae

2005-01-01

Heliplaatidest: Erdman/Sooäär" Peer Gynt & Other Stories" (esitlus 29. apr. Sakala keskuses), "Mi tango en Buenos Aires" (esitlus 24. apr. Sakala keskuses), Hinkus ja Maarja "Look Around" (esitlus 28. Rock Cafés grupiga Reel People)

A Different Kind of Web-Based Knowledge Management: The DTRA Acquisition ToolBook

Science.gov (United States)

2008-12-01

Reimbursement Order MIPR: Military Interdepartmental Purchase Request PWS: Performance Work Statement SOO: Statement of Objectives SOW: Scope of Work Figure 1...Competitive BAA: Broad Agency Announcement IACRO: Inter-Agency Cost Reimbur ement Order MIPR: Military Interdepartmental Purchas Request PWS

Differential microRNA expression signatures and cell type-specific association with Taxol resistance in ovarian cancer cells

Directory of Open Access Journals (Sweden)

Kim YW

2014-02-01

Full Text Available Yong-Wan Kim,1 Eun Young Kim,1 Doin Jeon,1 Juinn-Lin Liu,2 Helena Suhyun Kim,3 Jin Woo Choi,4 Woong Shick Ahn5 1Cancer Research Institute of Medical Science, The Catholic University of Korea, Seoul, Republic of Korea; 2Brain Tumor Center, Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, TX, USA; 3Cancer Rehab Laboratory, RH Healthcare Systems Inc, TX, USA; 4Harvard Medical School and Wellman Center for Photomedicine, Cambridge, MA, USA; 5Department of Obstetrics and Gynecology, The Catholic University of Korea, Seoul, Republic of Korea Abstract: Paclitaxel (Taxol resistance remains a major obstacle for the successful treatment of ovarian cancer. MicroRNAs (miRNAs have oncogenic and tumor suppressor activity and are associated with poor prognosis phenotypes. miRNA screenings for this drug resistance are needed to estimate the prognosis of the disease and find better drug targets. miRNAs that were differentially expressed in Taxol-resistant ovarian cancer cells, compared with Taxol-sensitive cells, were screened by Illumina Human MicroRNA Expression BeadChips. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR was used to identify target genes of selected miRNAs. Kaplan–Meier survival analysis was applied to identify dysregulated miRNAs in ovarian cancer patients using data from The Cancer Genome Atlas. A total of 82 miRNAs were identified in ovarian carcinoma cells compared to normal ovarian cells. miR-141, miR-106a, miR-200c, miR-96, and miR-378 were overexpressed, and miR-411, miR-432, miR-494, miR-409-3p, and miR-655 were underexpressed in ovarian cancer cells. Seventeen miRNAs were overexpressed in Taxol-resistant cells, including miR-663, miR-622, and HS_188. Underexpressed miRNAs in Taxol-sensitive cells included miR-497, miR-187, miR-195, and miR-107. We further showed miR-663 and miR-622 as significant prognosis markers of the chemo-resistant patient group. In particular, the

PSEN1 L226F mutation in a patient with early-onset Alzheimer’s disease in Korea

Directory of Open Access Journals (Sweden)

Bagyinszky E

2016-10-01

Full Text Available Eva Bagyinszky,1,* Sun Ah Park,2,* Hyung Jun Kim,2 Seong Hye Choi,3 Seong Soo A An,1 SangYun Kim4 1Department of BioNano Technology, Gachon University, Seongnam-si, 2Department of Neurology, Soonchunhyang University Bucheon Hospital, Bucheon, 3Department of Neurology, Inha University School of Medicine, Incheon, 4Department of Neurology, Seoul National University College of Medicine & Neurocognitive Behavior Center, Seoul National University Bundang Hospital, Seongnam-si, Republic of Korea *These authors contributed equally to this work Abstract: In this study, we report a first 226leucine (Leu mutation to phenylalanine (Phe in (PSEN1, CTC>TTC, L226F in Asia from a Korean early-onset Alzheimer’s disease (EOAD patient. Polymerase chain reaction (PCR–single strand conformation polymorphism, sequencing, and in silico predictions were performed. Previously, L226F was reported in EOAD patients by Zekanowski et al and Gómez-Tortosa et al. Disease phenotypes appeared in their thirties, and family history was positive in both cases. In our patient, age of onset was similar (37 years of age, but the mutation seemed to be de novo, since no affected family member was found. This leucine to phenylalanine substitution may cause additional stresses inside the transmembrane region due to large aromatic side chain and increased hydrophobic interactions with hydrocarbon chains in the membrane and its binding partners. Clinical phenotype of the mutation was aggressive progression into neurodegeneration, resulting in rapid cognitive decline. One of the patients was initially diagnosed with frontotemporal dementia, but the diagnosis was revised to AD upon postmortem studies in which Aβ plaques were seen. A second mutation, L226R, was found for the L226 residue. Similar to L226F, the patient with L226R also developed the first symptoms in his 30s, but EOAD was diagnosed in his 40s. These findings suggested that L226 might be an important residue in PSEN1

Elustiil = Lifestyle / Urve Kask

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Kask, Urve

2006-01-01

Töö- ja pereaastatel on leibkonna jaoks oluline eelarve, mis annab ette kulutuste mahu. Naiste ja meeste leibkondade sissetuleku tase on erinev ja toob esile sugudevahelise tarbimisstruktuuri erinevuse. Leibkonnaliikmete tarbimisstruktuur leibkonnapea soo järgi. Lastega ja lasteta leibkondade tarbimisstruktuur. Diagrammid

DIE MlllTERE BOUKUNS IN DIE NEDER. (1500-1800)~

African Journals Online (AJOL)

aatkundige verhoudings van die Middcleeue en faktore soos navwer tus3cn verskillende stcd'C, wrywings -met landshere c.d.m. in aanmerking gc~eem word, dan kan hieruit afgelei word dat stedelike militere aangeleenthede. 'n belang- rikc plek ...

uie twe

African Journals Online (AJOL)

dictatorships began to disturb the balance of power in Europe. tn South Africa this gave rise to a new crJsis of divided loyalties, culminating in arguments about the country's ... met leiers soos Stalin, Hitler en Mussolini het Europese ...

Advanced Materials and Processing 2010

Science.gov (United States)

Zhang, Yunfeng; Su, Chun Wei; Xia, Hui; Xiao, Pengfei

2011-06-01

Strain sensors made from MWNT/polymer nanocomposites / Gang Yin, Ning Hu and Yuan Li -- Shear band evolution and nanostructure formation in titanium by cold rolling / Dengke Yang, Peter D. Hodgson and Cuie Wen -- Biodegradable Mg-Zr-Ca alloys for bone implant materials / Yuncang Li ... [et al.] -- Hydroxyapatite synthesized from nanosized calcium carbonate via hydrothermal method / Yu-Shiang Wu, Wen-Ku Chang and Min Jou -- Modeling of the magnetization process and orthogonal fluxgate sensitivity of ferromagnetic micro-wire arrays / Fan Jie ... [et al.] -- Fabrication of silicon oxide nanowires on Ni coated silicon substrate by simple heating process / Bo Peng and Kwon-Koo Cho -- Deposition of TiOxNy thin films with various nitrogen flow rate: growth behavior and structural properties / S.-J. Cho ... [et al.] -- Observation on photoluminescence evolution in 300 KeV self-ion implanted and annealed silicon / Yu Yang ... [et al.] -- Facile synthesis of lithium niobate from a novel precursor H[symbol] / Meinan Liu ... [et al.] -- Effects of the buffer layers on the adhesion and antimicrobial properties of the amorphous ZrAlNiCuSi films / Pai-Tsung Chiang ... [et al.] -- Fabrication of ZnO nanorods by electrochemical deposition process and its photovoltaic properties / Jin-Hwa Kim ... [et al.] -- Cryogenic resistivities of NbTiAlVTaLax, CoCrFeNiCu and CoCrFeNiAl high entropy alloys / Xiao Yang and Yong Zhang -- Modeling of centrifugal force field and the effect on filling and solidification in centrifugal casting / Wenbin Sheng, Chunxue Ma and Wanli Gu -- Electrochemical properties of TiO[symbol] nanotube arrays film prepared by anodic oxidation / Young-Jin Choi ... [et al.] -- Effect of Ce additions on high temperature properties of Mg-5Sn-3Al-1Zn alloy / Byoung Soo Kang ... [et al.] -- Sono-electroless plating of Ni-Mo-P film / Atsushi Chiba, Masato Kanou and Wen-Chang Wu -- Diameter dependence of giant magneto-impedance effect in co-based melt extracted amorphous

Chlorine isotopic geochemistry of salt lakes in the Qaidam Basin, China

Digital Repository Service at National Institute of Oceanography (India)

Liu, W.G.; Xiao, Y.K.; Wang, Q.Z.; Qi, H.P.; Wang, Y.H.; Zhou, Y.M.; Shirodkar, P.V.

*Cl+ ion. Int. J. Mass Spectrom. Ion Process., 116: crysatallization of saline minerals in salt lake. J. Salt Lake 183-192. Sci., 2: 35-40 (in Chinese). Xiao, Y.K., Sun, D.P., Wang, Y.H., Qi, H.P. and Jin, L., 1992. Boron isotopic compositions of brine..., sediments, and source water in Da Qaidam Lake, Qinghai, China. Geochim. Cos- mochim. Acta, 56: 1.561-1568. Xiao, Y.K., Jin, L., Liu. W.G., Qi, H.P., Wang, W.H. and Sun, D.P., 1994a. The isotopic compositions of chlorine in Da Qaidam Lake. Chin. Sci...

A PROSPECTIVE STUDY ON FUNCTIONAL OUTCOME OF HUMERUS SHAFT FRACTURES TREATED WITH OPEN REDUCTION AND INTERNAL FIXATION WITH DYNAMIC COMPRESSION PLATE AND SCREWS

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Vidyadhar S. Donimath

2017-12-01

Full Text Available BACKGROUND Fracture of the humerus shaft accounts to 3% to 5% of all fractures. Majority of the fractures are unstable due to distraction force of the gravity in the upper limb and strong muscle contraction leading to displacement. Internal fixation and early mobilisation is more stressed on than splinting and prolonged immobilisation to allow earlier mobilisation and rapid return to work. The aim of the study was to study the union rates and the functional outcome and complications associated with shaft humerus fractures in KIMS Hospital. MATERIALS AND METHODS A prospective study which was carried out from October 2015 to September 2017 in Karnataka Institute of Medical Sciences, Hubballi, Karnataka State, India. In this study period, 25 cases of fracture shaft of the humerus were treated by open reduction and internal fixation using DCP. Skeletally mature patients with fresh humerus diaphysis fractures were included in the study. Pathological fractures and Tscherne grade 2 and above, Gustilo Anderson type2 and above were excluded from the study. RESULTS In our series of 25 cases, there were 21 men and 4 women with average age of 42.5 years. Sixteen (64% cases were due to RTA and with predominance of right side. Transverse fractures were most common that is 15 (60% patients. Eleven (31% cases were having associated injuries. 92% of the fractures united with good to excellent outcome. There were 2 (8% cases of non-union due to infection and comminution. CONCLUSION Open reduction and internal fixation with dynamic compression plate is still the standard treatment of choice for fracture shaft of humerus achieving excellent to good functional outcome.

Exposure to waterborne Cu inhibits cutaneous Na⁺ uptake in post-hatch larval rainbow trout (Oncorhynchus mykiss).

Science.gov (United States)

Zimmer, Alex M; Brauner, Colin J; Wood, Chris M

2014-05-01

In freshwater rainbow trout (Oncorhynchus mykiss), two common responses to acute waterborne copper (Cu) exposure are reductions in ammonia excretion and Na(+) uptake at the gills, with the latter representing the likely lethal mechanism of action for Cu in adult fish. Larval fish, however, lack a functional gill following hatch and rely predominantly on cutaneous exchange, yet represent the most Cu-sensitive life stage. It is not known if Cu toxicity in larval fish occurs via the skin or gills. The present study utilized divided chambers to assess cutaneous and branchial Cu toxicity over larval development, using disruptions in ammonia excretion (Jamm) and Na(+) uptake (Jin(Na)) as toxicological endpoints. Early in development (early; 3 days post-hatch; dph), approximately 95% of Jamm and 78% of Jin(Na) occurred cutaneously, while in the late developmental stage (late; 25 dph), the gills were the dominant site of exchange (83 and 87% of Jamm and Jin(Na), respectively). Exposure to 50 μg/l Cu led to a 49% inhibition of Jamm in the late developmental stage only, while in the early and middle developmental (mid; 17 dph) stages, Cu had no effect on Jamm. Jin(Na), however, was significantly inhibited by Cu exposure at the early (53% reduction) and late (47% reduction) stages. Inhibition at the early stage of development was mediated by a reduction in cutaneous uptake, representing the first evidence of cutaneous metal toxicity in an intact aquatic organism. The inhibitions of both Jamm and Jin(Na) in the late developmental stage occurred via a reduction in branchial exchange only. The differential responses of the skin and gills to Cu exposure suggest that the mechanisms of Jamm and Jin(Na) and/or Cu toxicity differ between these tissues. Exposure to 20μg/l Cu revealed that Jamm is the more Cu-sensitive process. The results presented here have important implications in predicting metal toxicity in larval fish. The Biotic Ligand Model (BLM) is currently used to predict

Dance for Adults With Fibromyalgia-What Do We Know About It? Protocol for a Scoping Review.

Science.gov (United States)

Bidonde, Julia; Boden, Catherine; Busch, Angela J; Goes, Suelen M; Kim, Soo; Knight, Emily

2017-02-22

the results, (6) consulting, and (7) disseminating the knowledge. The search, title, and abstract are now completed; full text screening was carried out and authors are awaiting interlibrary loans and translations. Data extraction will start shortly after full text 'screening' is completed. Completion is expected in Fall 2017. To our knowledge this will be the first attempt to systematically identify knowledge of dance as a potential intervention for adults with fibromyalgia. This scoping review offers a feasible means for describing the evidence specific to dance and fibromyalgia; results will provide unique insights concerning the breadth and depth of literature in the area. An analysis of this body of literature as a whole may reveal new research directions or unknown ways this intervention could strengthen current management approaches of the disease. ©Julia Bidonde, Catherine Boden, Angela J Busch, Suelen M Goes, Soo Kim, Emily Knight. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 22.02.2017.

HIV ravi võtab peagi sadu miljoneid / Kadri Ibrus

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Ibrus, Kadri

2007-01-01

HIV-positiivsete ravikulud on Eestis hüppeliselt kasvamas, kuna aastate eest nakatunud inimesed hakkavad nüüd vajama tõsist ravi. Lisaks diagrammid: Eestis levib HIV maailmas pea kõige kiiremini ; 2006. aastal nakatunud soo ja vanuse järgi

Eesti sigaretiturg 2005. aastal / E Ahermaa

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Ahermaa, E

2006-01-01

Ülevaade Eesti sigaretiturul 2005. aastal aset leidnud muutustest. Tabelid: Suitsetajate osakaal soo järgi (% vastanutest); Sigarettide illegaalse kaubanduse maht ja arvestuslik maksutulukaotus. Diagrammid: Legaalsete ja illegaalsete sigarettide vahel valiku tegemine; Sigarettide hinna ja aktsiisi võrdlus Eestis 2005. ja 2009. aastal

Muusikast, muinsuskaitsest, keraamilistest lauanõudest ... : TPÜ kultuuriteaduskonna magistrantide ja doktorantide teaduskonverents 23. aprillil / Risto Paju

Index Scriptorium Estoniae

Paju, Risto

2001-01-01

Teaduskonverentsi juhatasid sisse K. Kirme, R. Pullat, H. Uibu. Ettekannetega esinesid T. Parktal, L. Suurmaa, M. Raabe, M. Loit, T. Soosõrv, M. Aarma, T. Tohver, R. Paju, O. Kozlova, A. Lõugas, M. Talvik, S. Sultson, P. Kängsep, A. Hrenova, J. Raihhelgauz

26 Resensie Barendse WEB 02.pmd

African Journals Online (AJOL)

Owner

roman/memoir/ bundel/tesis/geskrif”. Soos die titel beloof, is die boek chaoties. Ek gee daarom 'n kort op- somming van die verhaal in 'n poging om orde te skep binne die chaos: Die boek begin met die verteller wat vanuit 'n sielkundige.

Plaaslike bestuur en sy rol in fisiese beplanning

Directory of Open Access Journals (Sweden)

P. Z.J. van Vuuren

1965-03-01

Full Text Available Somaar uit die staanspoor wil ek verduidelik dat my bena- dering miskien vir sommige van u as te prakties en van te algemene aard mag voorkom en u moontlik sou verkies het dat ek meer moes uitwei oor die tegnieke en die beginsels van beplanning. Daardie aspekte laat ek egter aan die persone oor wat beter gekwalifiseer is om daaroor te praat as ek. Dit beteken egter nie dat ek, en ander soos ek, die aanvaarde en beproefde beginsels vir goeie beplanning kan ignoreer nie. Ek wil egter met hierdie inleidende woorde volstaan en dit aan u oordeel oorlaat om te besluit of u met hierdie bena- dering van my saamstem. Indien u nie met my saamstem nie, dan vertrou ek dat wat ek hier te sê het u minstens sal prikkel en u miskien sal aanspoor om die saak te stel soos u dit sien.

Report on the Second KIMS-CNA Conference: The PLA Navys Build-Up and ROK-USN Cooperation

Science.gov (United States)

2009-02-01

Modernization (London and Washington, DC: Kegan Paul International and The AEI Press, 1996), p. 274. See also his “China’s Push Through the South China Sea...to change its nature of the PLA Navy naval strategy from “brown water” force to “ green /blue water” navy enable to secure its vast maritime...and “full ocean-going green water fleet.” It is conceivable that the Chinese navy’s goal of its operational capability is not “blue water navy,” but

Turism rikastab : rahvusvaheline turismikonverents

Index Scriptorium Estoniae

2006-01-01

28. septembril toimus Tallinnas Rahvusraamatukogus rahvusvaheline turismikonverents"Turism rikastab". Ülevaade majandus- ja kommunikatsiooniministeeriumi majandusarengu asekantsleri Maria Värtoni, Graham Mckenzie, Linnar Viigi, Nick Skelloni, Mario Ascencao (Haagi ülikool), David Carsoni (Ulsteri ülikool), Vesa Heikkineni ja Imre Sooääre ettekannetest

"Siin me oleme" staarid paljastasid Muhumaal saladusi / Katrin Pauts

Index Scriptorium Estoniae

Pauts, Katrin, 1977-

2002-01-01

Sulev Nõmmiku populaarse komöödiafilmi "Siin me oleme" (Eesti Telefilm 1978) osatäitjad Lia Laats, Kadri Jäätma, Väino Puura ja Imre Sooäär meenutasid Pädaste mõisas kokku tulles filmimise rõõme ja muresid

29 Resensie Botha WEB 03.pmd

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Owner

Willem Anker is sedert 2004 bekend as dra- maturg wat met innoverende teaterstukke soos Slaghuis, Skrapnel en Samsa-masjien die grense van teater uitdaag. In 2007 verskyn sy bekroonde debuutroman, Siegfried, waarmee beide die bildungsroman en die sogenaamde heldereis as subgenres uitgedaag word. In.

Persistence Increases in the Absence of the Alarmone Guanosine Tetraphosphate by Reducing Cell Growth

Science.gov (United States)

2016-08-16

Pennsylvania, Pennsylvania State University, University Park, 16802- 4400, USA. 2Department of Biochemistry and Molecular Biology, Pennsylvania State...of Toxin- Antitoxin Activity. Cell 154, 1140–1150 (2013). 26. Osbourne, D. O., Soo, V. W. C., Konieczny, I. & Wood, T. K. Polyphosphate, cyclic AMP

The Design and Development of an Intelligent Planning Aid

Science.gov (United States)

1986-07-01

Corps sector, the Worthe terminal Moralrie, which uses to over SOO feet and forms a hilly spine from northwest to southeast across...European neutrals with nig- ged geography and territorial armies is the ana or hedgehog defense, which uses terrain choke points and towns which

Chinese herbal dose in ancient and modern times: a comparative study.

Science.gov (United States)

He, Shimin

2013-04-01

Appropriate dose guarantees Chinese herb's safety and effectiveness. There are adult dose criteria for Chinese herbs in decoction in the Pharmacopoeia of the People's Republic of China (2010 Edition) at present. But Chinese herbs have been frequently used in much higher doses than the dose criteria. This study has been conducted to test the dependability of the dose criteria. Twenty Chinese herbs were selected as representatives and their adult doses in decoction in Bei Ji Qian Jin Yao Fang, a famous ancient literature, have been reviewed and compared with those in the Pharmacopoeia of the People's Republic of China (2010 Edition). The adult dose criteria for all these 20 Chinese herbs in the Pharmacopoeia of the People's Republic of China (2010 Edition) haven't covered those in Bei Ji Qian Jin Yao Fang. Furthermore, maximal adult doses in the dose criteria are much lower than those in Bei Ji Qian Jin Yao Fang. The dose criteria in the Pharmacopoeia of the People's Republic of China (2010 Edition) are not comprehensive enough. Studying ancient literatures is an effective method to gain precious Chinese herbs' dose data and helps for new dose criteria's establishment in the future.

Retarderi na teškim vozilima

Directory of Open Access Journals (Sweden)

Joško Rapanić

2012-10-01

Full Text Available The objective of all the braking systems fitted in vehicles isto reduce the speed, as well as to keep them at a standstill. Inorder to increase the active road traffic safety, the experts inthe leading vehicle manufacturer companies are trying from day to day to find a more efficient solution of the highest possiblequality. Braking problems, i.e. problems of stopping the vehiclesare closely related to time, forces, momentum, mass andother physical quantities. This is best seen in the braking ofheavy duty vehicles, trucks, buses, where the braking efficacyis questionable due to high inertia forces caused by heavyweight and more recently relatively high speeds. Such vehiclesare fitted with system of brakes that operate on compressed airor combination of pneumatics and hydraulics, since the driverhas not got enough power to achieve appropriate braking effect.However, the biggest problems occur by trucks runningdownhill, when the braking system is operated continuously fora longer period of time. This causes heating and overheating ofthe system elements ("fading", thus reducing the braking effect.In extreme cases, particularly if the system is poorly maintained,it can eventually fail completely.Because of the mentioned reasons for difficulties in brakingof trucks, such vehicles have been recently fitted with anauxiliary slow-down system. This system is completely independentfromthe main one on the wheels and is used exclusivelyfor slowing down or for maintaining of speed.

Ajateenistusest, ausalt! / Kim Järvepõld

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Järvepõld, Kim

2007-01-01

Ilmunud ka: Postimees : na russkom jazõke, 9. apr. 2007, lk. 7. Autor leiab, et põhiseaduslik nõue, mille järgi on kõik Eesti kodanikud kohustatud osa võtma riigikaitsest, pole vastavuses tegeliku olukorraga, ning arvab, et kohustuslik ajateenistus tuleb kaotada või viia kooskõlla põhiseadusega

Application of the Single Hardening Model in the Finite Element Program ABAQUS

DEFF Research Database (Denmark)

Jakobsen, Kim Parsberg

model, developed by Lade and Kim (Kim & Lade 1988, Lade & Kim 1988a, Lade & Kim 1988b) is implemented as a user defined material module, UMAT, in the commercial finite element program, ABAQUS. The advantages of the Single Hardening Model Iie in its ability to predict elastic and plastic displacements...

胡阿祥:《东晋南朝侨州郡县与侨流人口研究》%Axiang Hu, Dongjin Nanchao Qiao zhoujunxian yu qiaoliu renkou yanjiu

Institute of Scientific and Technical Information of China (English)

孔祥军

2010-01-01

@@ The epoch of the Wei, Jin and Southern and Northern dynasties was perhaps the most chaotic and complicated era in Chinese history, in terms of regime instability. Except for a short period of unification under the Western Jin, this era was marked by continuous division and confrontation. Accordingly, professional historians and amateur history lovers alike prefer to examine the unified and the powerful Han and Tang dynasties and are often unwilling to deal with this discordant and tumultuous time.However,the furious conflicts of this era actually promoted ethnic amalgamations,territorial exploits,cultural transmission and intellectual communication,therefore,an in-depth study of this period is not only worthwhile,but necessary.

Therapeutic deep brain stimulation worsening dysprosody in Parkinson’s disease – an unexplored entity

Directory of Open Access Journals (Sweden)

Shoaib M

2018-03-01

Full Text Available Maria Shoaib,1 Muhammad Taimoor Khan2 1Department of Medicine, Dow Medical College, Karachi, Pakistan; 2Department of Neurology, Charleston Area Medical Center/West Virginia University, Charleston, WV, USA  We read this article, “Altered emotional recognition and expression in patients with Parkinson’s disease” by Jin et al1 with great interest and appreciate the novel information provided on altered emotional processing in pre-deep brain stimulation (DBS Parkinson’s disease (PD patients and we would like to add our feedback on the role of DBS on nonmotor and emotional components of PD.View the original paper by Jin and colleagues. 

PREFACE: 3rd International Symposium on Functional Materials 2009 (ISFM 2009) 3rd International Symposium on Functional Materials 2009 (ISFM 2009)

Science.gov (United States)

Kiwon, Kim; Li, Lu; Taehyun, Nam; Jouhyeon, Ahn

2010-05-01

The 3rd International Symposium on Functional Materials 2009 (ISFM 2009) and its preconference, Advances in Functional Materials 2009 (AFM 2009), were successfully held in the Republic of Korea from 15-18 June 2009 and in the People's Republic of China from 8-12 June 2009, respectively. The two conferences attracted over 300 oral and poster presentations from over 12 countries including Australia, Canada, China, Germany, Japan, India, Israel, Korea, The Netherlands, Thailand, the UK and the USA. In the two conferences, eight keynote lectures were delivered by S Miyazaki, S A Akbar, D J Singh, C Suryanarayana, M~Greenblatt, H Zhang, T Sato and J Ding. This topical issue of Physica Scripta contains papers presented at the ISFM 2009 and AFM 2009. Keyan Li from Dalian University, People's Republic of China, presents some empirical formulae to estimate the elastic moduli of rocksalt-, zincblende- and chalcopyrite-structured crystals, on the basis of electronegativities of bonded atoms in the crystallographic frame. Min-Jung Kim from Hanyang University, Korea, reports on the preparation and characterization of carboxyl functionalization of magnetite nanoparticles for oligonucleotide immobilization. F Yan from the National University of Singapore studies the fabrication of Bi(Fe0.5Sc0.5)O3-PbTiO3 (BSF-PT) thin films by pulsed laser deposition, and the enhanced magnetic moment with respect to BiFeO3-PbTiO3. Dong-Gil Lee from Pusan National University, Korea, reports on the sterilization of enteropathogenic Escherichia coli using nanofiber TiO2 films prepared by the electrostatic spray method. Sang-Eun Park from the Korea Institute of Science and Technology reports on the study of encapsulated Fe3O4 nanoparticles with a silica thin layer with a reversible capacity of about 363 mAhg-1. Other researchers report on many other exiting achievements in the fields of ferromagnetic materials, magneto-optical materials, thermoelectric materials, shape memory materials, fuel-cell and

The relationship between low levels of mindfulness skills and pathological worry: the mediating role of psychological inflexibility

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Francisco J. Ruiz

2014-10-01

Full Text Available Mindfulness-based interventions have recently been proposed for the treatment of generalized anxiety disorder (GAD. However, the specific nature of the relationship between mindfulness skills and pathological worry is still not very well known. This study analyzes the mediating role of psychological inflexibility-a central construct in the acceptance and commitment therapy (ACT model of psychopathology-in the effect of mindfulness skills on pathological worry. A total of 132 nonclinical participants completed questionnaires assessing the constructs of interest: the Penn State Worry Questionnaire (PSWQ, the Acceptance and Action Questionnaire - II (AAQ-II, and the Kentucky Inventory of Mindfulness Skills (KIMS. Because the Spanish translation of the KIMS used lacked of a formal validation, its psychometric properties and factor structure were previously evaluated. This process led to a reduced version of the KIMS that showed good internal consistency and factor structure. Mediation analyses revealed that psychological inflexibility fully mediated the effects of mindfulness skills as a set on pathological worry. Regarding specific mindfulness skills, psychological inflexibility was shown to be a mediator and suppressor, respectively, of the relationship between acceptance without judgment and act with awareness on worry. Results are discussed emphasizing the need of using mindfulness exercises to promote psychological flexibility.

Archtecture According to Children : Tree House World / Pille Runnel

Index Scriptorium Estoniae

Runnel, Pille, 1974-

2015-01-01

Linnalaste ja -noorte teemalisest näitusest "Niisama linnas" ("Chilling Around the Town") Eesti Rahva Muuseumis 16. mai 2014-11.01 2015. Teostuse on leidnud ka onnikavandite võistlusele auto-onni idee saatnud 10-aastase poisi Artur Soo unistus - "Onn ratastel OÜ" - vanasse veoautosse ehitatud onn

Sad naslazhdeni / Galina Balashova

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Balashova, Galina

2003-01-01

Eesti Metallikunstnike Liidu korraldatud ehtekunsti näitusest "Palve. Puudutus. Patt" Tallinna Kunstihoone galeriis. Taimi Soo kujundusest. Jaanika Pajuste, Julia Pihlaku, Urve Küttneri, Andrei Balashovi, Jaan Pärna, Lilian Linnaksi, Kärt Summataveti, Rein Metsa ja Harvi Varkki töödest näitusel

AMMONIUM TOXICITY AND NITRATE RESPONSE OF AXENICALLY GROWN DACTYLORHIZA-INCARNATA SEEDLINGS

NARCIS (Netherlands)

DIJK, E; ECK, N

1995-01-01

The response to ammonium- and nitrate-nitrogen of seedlings of the calcicole orchid species Dactylorhiza incarnata (L.) Soo was tested in axenic in vitro culture of c. 3-month-old protocorms. A pronounced toxicity of ammonium ions was observed. Seedlings raised from plants of a coastal population

http://spilplus.journals.ac.za/

African Journals Online (AJOL)

Shakespeare (met name soos Malvolio, Benvolio), Congreve (vergelyk die volgende name, almal uit The Way of the World: Sir Willfull, Lady Wishfort, Petulant, Mirabell,. Fainall), Dickens (met sy Scrooge, Oliver Twist, Richard Swiveler), Sheridan (Lady. Sneerwell, Mrs. Candour uit The School for Scandal) en selfs Etienne ...

36 http://spilplus.journals.ac.za/

African Journals Online (AJOL)

behaviorisme, veral van Watson (Behaviorism, 1924) en ;.leiss (A Theoretical basis of human behaviour, 1924, hersiene uitgawe 1929). Soos bekend, is die behaviorisme die opvatting dat psigologiese verskynsels voldoende behandel en verklaar kan word deur 'n studie van die reaksies van 'n organisme op stimuli sonder ...

'N perd van 'n ander kleur sas somerset (1942-1986) | Wessels ...

African Journals Online (AJOL)

Naas die bekende vlootvaartuie soos byvoorbeeld duikbote, vliegdekskepe en missieldraende aanvalsvaartuie, is daar in die meeste vlote ter werêld ander vaartuigtipes wat soms 'n groot deel van hul leeftyd hawegebonde is, maar nogtans waardevolle diens ten behoewe van ander skepe of ter beskerming van hawens ...

'N PERD VAN 'N ANDER KLEUR SAS SOMERSET (1942-1986)

African Journals Online (AJOL)

Naas die bekende vlootvaartuie soos byvoorbeeld duikbote, vliegdekskepe en missieldraende aanvalsvaartuie, is daar in die meeste vlote ter wereld ander vaartuigtipes wat soms 'n groot deel van hul leeftyd hawegebonde is, maar nogtans waardevolle diens ten behoewe van ander skepe of ter beskerming van hawens ...

Ontstaan, rol en betekenis van die Afrikaanse koerante

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G. P. Pienaar

1975-05-01

Full Text Available Die koerant soos ons dit vandag ken, het pas 2 000 jaar oud geword, nou wel nie altyd gedruk en met kleurfoto’s versier nie, maar nietemin herkenbaar nuusblad. Ons dank vandag die Romein Cicero vir ons kennis van die heel oudste koerante.

Die hormoonfabriek. Saskia Goldschmidt. Vertaal deur Daniel Hugo ...

African Journals Online (AJOL)

wat dan voortgaan met kommentaar op. “die skrywer” se boek. Die onderhawige teks, Die Hormoonfabriek, is Daniel Hugo se Afrikaanse vertaling uit Nederlands van Saskia Goldschmidt se gelyknamige debuutroman.Dit is dus, soos alle vertaalde romans, minstens twee maal geskryf: eers in Nederlands deur Goldschmidt, ...

De betekenis van Johan Buitendags stellingname in theologie der ...

African Journals Online (AJOL)

29 juli 2016 ... zich aan ons voordoet (Kants 'Wirklichkeit als Erscheinung'), maar over het geheel der dingen. 'soos dit kwansuis is' (Buitendag 2013:1). In Buitendags visie betekent dit dat systematische theologie probeert te begrijpen hoe de werkelijkheid in elkaar steekt wanneer wij daarmee geconfronteerd worden.

Synthesis, Transfer, and Characterization of Nanoscale 2-Dimensional Materials

Science.gov (United States)

2015-09-01

Shi Y, Hamsen C, Jia X, Kim KK, Reina A, Hofmann M, Kong J. Synthesis of few-layer hexagonal boron nitride thin film by chemical vapor deposition...hexagonal boron nitride layers. Nano Letters. 2010;10(8):3209–3215. 12. Kim KK, Hsu A, Jia X, Kim SM, Shi Y, Hofmann M, Kong J. Synthesis of...microscopy. Physical Review B. 2009;80(15):155425. 33. Kim KK, Hsu A, Jia X, Kim SM, Shi Y, Hofmann M, Kong J. Synthesis of monolayer hexagonal boron

The effect of dietary antioxidant on the COPD risk: the community-based KoGES (Ansan–Anseong cohort

Directory of Open Access Journals (Sweden)

Joshi P

2015-10-01

Full Text Available Pankaj Joshi,1,2 Woo Jin Kim,3,4 Sang-Ah Lee1–3 1Department of Preventive Medicine, 2BIT Medical Convergence Graduate Program, 3Department of Internal Medicine, 4Environmental Health Center, Kangwon National University School of Medicine, Chuncheon-si, Gangwon-do, South Korea Background: Dietary antioxidants have been suggested to have protective role against chronic obstructive pulmonary disease (COPD, but few prospective studies examined this relationship. The prospective study was conducted to evaluate the effect of dietary antioxidants on COPD risk and lung function in the Korean population.Methods: The data were collected from the community-based Korean Genome Epidemiology Study (KoGES cohort. To diagnose COPD, forced expiratory volume (FEV1 and forced vital capacity (FVC were measured by spirometry. The dietary intake of antioxidant vitamins was estimated from validated Food-Frequency Questionnaire. For the analysis, 325 COPD patients and 6,781 at risk subjects were selected from the cohort of 10,038 subjects. Multiple logistic regression models were used to examine the odds ratio (OR after adjusting for age, sex, marital status, income, history of asthma, history of tuberculosis, and smoking.Results: The risk of COPD was positively associated with aging, low education, low household income, lower body mass index, and cigarette smoking. The risk of COPD decreased with increase in the dietary vitamin C (ORQ1 vs Q5=0.66, Ptrend=0.03 and vitamin E (ORQ1 vs Q5=0.56, Ptrend=0.05 intake, predominantly, in men (Ptrend=0.01 and 0.05 for vitamins C and E, respectively. In addition, the lung function was significantly improved with increase in vitamins C (FEV1, P=0.04; FVC, P=0.03 and E (FEV1, P=0.03; FVC, P=0.04 intake. No statistically significant interactions were observed between smoking and vitamin C or E intake in relation to COPD risk among men.Conclusion: Our results suggest the independent beneficial effect of antioxidants, particularly

Risk factors for chronic obstructive pulmonary disease among never-smokers in Korea

Directory of Open Access Journals (Sweden)

Lee SJ

2015-03-01

Full Text Available Seok Jeong Lee,1 Seo Woo Kim,1 Kyoung Ae Kong,2 Yon Ju Ryu,1 Jin Hwa Lee,1 Jung Hyun Chang1 1Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, 2Department of Clinical Trial Center, School of Medicine, Ewha Womans University, Seoul, Republic of Korea Background: Chronic obstructive pulmonary disease (COPD patients include those who have never smoked. However, risk factors other than smoking in never-smokers have not been elucidated sufficiently. This study investigated the risk factors for COPD among never-smokers in Korea using population-based data. Methods: The data were retrieved from the Korean National Health and Nutrition Survey IV conducted from 2007 to 2009. Among subjects aged 40 years or older who underwent appropriate pulmonary function tests, never-smokers not diagnosed with asthma and not showing a restrictive pattern on pulmonary function tests were enrolled. Risk factors of COPD in never-smokers were analyzed using logistic regression models. Results: Among 24,871 participants in the representative Korean cohort, 3,473 never-smokers were enrolled. COPD patients accounted for 7.6% of the never-smokers. In the logistic regression analysis, low education status (odds ratio [OR]: 2.0; 95% confidence interval [CI]: 1.2–3.2, occupational exposure (OR: 2.6; 95% CI: 1.3–5.3, a history of tuberculosis (OR: 4.5; 95% CI: 2.3–8.7, bronchiectasis (OR: 6.0; 95% CI: 1.4–25.4, male sex (OR: 4.2; 95% CI: 2.6–6.7, advanced age (60–69 years vs 40–49 years; OR: 3.8; 95% CI: 2.0–7.0, and being underweight (body mass index <18.5 vs 18.0–24.9 kg/m2; OR: 3.1; 95% CI: 1.0–9.4 were associated with the development of COPD. Conclusion: Low education status, manual labor, a history of tuberculosis and bronchiectasis, as well as male sex, advanced age and being underweight were risk factors for COPD in Korean never-smokers. Keywords: socioeconomic status, chronic obstructive pulmonary disease, never-smoker

Leadership Development From A Systems Psychodynamic Consultancy Stance

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W. J. De Jager

2003-11-01

Hierdie navorsing poog om die impak van ‘n leierskapsontwikkelingsprogram wat aangebied is vanuit die sistemiese psigodinamiese perspektief, te evalueer. Die doel was om psigoanalitiese ingeligte leiers te ontwikkel om verandering en transformasie in die gedurige veranderende en transformerende Nuwe Ekonomie netwerk organisasie, te lei. Ten einde dit te bolwerk is. ‘n Groep -verhoudinge-opleidingsprogram is aangebied vir 30 leiers. Kwalitatiewe evaluasie deur van begrondingsteorie gebruik te maak gedurende, die post-intervensie fokus groepe het ‘n groepbewustheid aangedui van psigodinamiese leierskapgedrag soos die regressie na dikwelse patologiese leierskapspersoonlikheidskenmerke, regressie in onbewustelike groep- en organisatoriese prosesse soos die basiese aanname-groep, die koverte-koalisie- en sosiaal-gestruktureerde-verdedigingsisteme teen verandering en transformasie. Insig is ook in die nuwe leierskap rol en die opneem van persoonlike outoriteit in die netwerk organisasie wat moet funksioneer as ‘n sistemiese geheel, bekom. Aanbevelings word gemaak om die leierskapsrol in verandering in terme van vaardighede in die Nuwe Ekonomienetwerkorganisasie, te bevorder.

Multiresolution Algorithms for Processing Giga-Models: Real-time Visualization, Reasoning, and Interaction

Science.gov (United States)

2012-04-23

Interactive Virtual Hair Salon , Presence, (05 2007): 237. doi: 2012/04/17 12:55:26 31 Theodore Kim, Jason Sewall, Avneesh Sud, Ming Lin. Fast...in Games , Utrecht, Netherlands, Nov. 2009. Keynote Speaker, IADIS International Conference on Computer Graphics and Visualization, Portugal, June 2009...Keynote Speaker, ACM Symposium on Virtual Reality Software and Technology, Bordeaux, France, October 2008. Invited Speaker, Motion in Games , Utrecht

Evaluation of the StressWave Cold Working (SWCW) Process on High-Strength Aluminum Alloys for Aerospace

Science.gov (United States)

2009-02-01

Alloy Spot- welds by Cold Working,” 13 International Pacific Conference on Automotive Engineering (IPC-13), Gyeongju, Korea, August 2005. 7. Kim...so that it remains normal to the indenting direction. The restraint provided around the area to be cold worked minimizes surface upset (albeit...direction. The restraint provided around the area to be cold worked minimizes surface upset (albeit small without a PF). The stabilizing aspect

Kim, czym, kiedy, gdzie i dlaczego są polscy Żydzi? Wyobrażanie, konstruowanie i zawłaszczanie Żydów polskich

Directory of Open Access Journals (Sweden)

Scott Ury

2017-12-01

Full Text Available Who, what, when, where, and why is Polish Jewry? Envisioning, constructing, and possessing Polish Jewry This article examines the different ways that various communities of scholars imagine, research and teach about “Polish Jewry.” Focusing on scholarship written in Israel, Poland and the United States over the past generation or two, the article argues that each particular community of scholars constructs a particular version of Polish Jewry and that each of these versions is deeply influenced by contemporary social, political and communal needs and demands. As a result, scholars very often end up constructing radically different versions of Polish Jewish history and society. These scholarly differences reflect many of the challenges and difficulties related to researching and writing about the history and culture of Polish Jews since 1989.   Kim, czym, kiedy, gdzie i dlaczego są polscy Żydzi? Wyobrażanie, konstruowanie i zawłaszczanie Żydów polskich Artykuł stanowi omówienie odmiennych sposobów, jakimi różne społeczności badaczy wyobrażają grupę polskich Żydów, badają ją i nauczają o niej. Na podstawie analizy działalności naukowej badaczy z Izraela, Polski i Stanów Zjednoczonych ostatnich dwóch pokoleń autor pokazuje, że każda społeczność badaczy konstruuje własny, specyficzny obraz grupy zwanej „polskimi Żydami” i że obrazy te pozostają pod przemożnym wpływem współczesnych potrzeb i wymogów o naturze społecznej, politycznej i wspólnotowej. Na skutek tych różnic uczeni tworzą często radykalnie odmienne obrazy historii i społeczeństwa polskich Żydów. Różnice stanowią odzwierciedlenie przeszkód i utrudnień, jakie po 1989 roku wiążą się z badaniem i opisywaniem historii i kultury polskich Żydów.

Automatic online and real-time tumour motion monitoring during stereotactic liver treatments on a conventional linac by combined optical and sparse monoscopic imaging with kilovoltage x-rays (COSMIK)

Science.gov (United States)

Bertholet, Jenny; Toftegaard, Jakob; Hansen, Rune; Worm, Esben S.; Wan, Hanlin; Parikh, Parag J.; Weber, Britta; Høyer, Morten; Poulsen, Per R.

2018-03-01

The purpose of this study was to develop, validate and clinically demonstrate fully automatic tumour motion monitoring on a conventional linear accelerator by combined optical and sparse monoscopic imaging with kilovoltage x-rays (COSMIK). COSMIK combines auto-segmentation of implanted fiducial markers in cone-beam computed tomography (CBCT) projections and intra-treatment kV images with simultaneous streaming of an external motion signal. A pre-treatment CBCT is acquired with simultaneous recording of the motion of an external marker block on the abdomen. The 3-dimensional (3D) marker motion during the CBCT is estimated from the auto-segmented positions in the projections and used to optimize an external correlation model (ECM) of internal motion as a function of external motion. During treatment, the ECM estimates the internal motion from the external motion at 20 Hz. KV images are acquired every 3 s, auto-segmented, and used to update the ECM for baseline shifts between internal and external motion. The COSMIK method was validated using Calypso-recorded internal tumour motion with simultaneous camera-recorded external motion for 15 liver stereotactic body radiotherapy (SBRT) patients. The validation included phantom experiments and simulations hereof for 12 fractions and further simulations for 42 fractions. The simulations compared the accuracy of COSMIK with ECM-based monitoring without model updates and with model updates based on stereoscopic imaging as well as continuous kilovoltage intrafraction monitoring (KIM) at 10 Hz without an external signal. Clinical real-time tumour motion monitoring with COSMIK was performed offline for 14 liver SBRT patients (41 fractions) and online for one patient (two fractions). The mean 3D root-mean-square error for the four monitoring methods was 1.61 mm (COSMIK), 2.31 mm (ECM without updates), 1.49 mm (ECM with stereoscopic updates) and 0.75 mm (KIM). COSMIK is the first combined kV/optical real-time motion

Propagation of experimental uncertainties using the Lipari-Szabo model-free analysis of protein dynamics

International Nuclear Information System (INIS)

Jin Danqing; Andrec, Michael; Montelione, Gaetano T.; Levy, Ronald M.

1998-01-01

In this paper we make use of the graphical procedure previously described [Jin, D. et al. (1997) J. Am. Chem. Soc., 119, 6923-6924] to analyze NMR relaxation data using the Lipari-Szabo model-free formalism. The graphical approach is advantageous in that it allows the direct visualization of the experimental uncertainties in the motional parameter space. Some general 'rules' describing the relationship between the precision of the relaxation measurements and the precision of the model-free parameters and how this relationship changes with the overall tumbling time (τm) are summarized. The effect of the precision in the relaxation measurements on the detection of internal motions not close to the extreme narrowing limit is analyzed. We also show that multiple timescale internal motions may be obscured by experimental uncertainty, and that the collection of relaxation data at very high field strength can improve the ability to detect such deviations from the simple Lipari-Szabo model

'n ope brief aan Dorian Gray en 'n peiling van die Afrikaanse ...

African Journals Online (AJOL)

19 Mrt. 2018 ... kritieser lesers (nie net vriende, Instagram-ondersteuners en kollegas nie) en 'n in- tensiewer ontginning van beskikbare toetsterreine. Het hy ooit gedigte voorgelê vir. NB-Uitgewers se Nuwe stemme-reeks? Sterk debutante soos Ilse van Staden, Bernard. Odendaal, Ronelda Kamfer, Loftus Marais, Hennie ...

,t'.: O.)IISPIIONG EN ONTWIKKELIN •• VAN ItIE ONDERRI ••F'LM

African Journals Online (AJOL)

4. Die onderrigfilms wat vir skole bestaan het, het aspekte soos verhale, tegniese vakke, geografie, geskiedenis, taal en higiene gedek. Bogenoemde films was egter baie beperk in terme van opvoedkundige waarde aangesien dit bestaan het uit materiaal wat vanaf kommersiele films afkomstig was en later aangepas is Die.

P. J. N. Smal, Die Universalisme in die Psalms. Academisch ...

African Journals Online (AJOL)

Test

dat die historiese element in Israel se Godsopenbaring en daarmee die insig in sy betekenis te kort gedoen word. Die betekenis van die studie vir die historia revelationis is daardeur gering; as duidelike „tydlose” sistematisering van Outestamentiese gegewens oor die betrokke onder- werpe, soos die laaste hoofstuk, bl.

The psychological experience of women who survived HELLP ...

African Journals Online (AJOL)

Die tema van nie weet en beswyming en/of surrealistiese ervaring ondersteun die kognitiewe aspekte van die HELLP sindroom. Temas wat gevoelens van geen beheer, warrelwind en/of vinnige tempo en ondersteuning uitgesprek het, het saam opgetree om die ervaring te bind. Ten slotte,emosies soos woede, ...

Disainiaasta / Bruno Tomberg

Index Scriptorium Estoniae

Tomberg, Bruno, 1925-

2006-01-01

Näitus "40 aastat disainiharidust Eestis" Eesti Tarbekunsti- ja Disainimuuseumis 19. VIII-17. IX ja Eesti disaini auhinna nominentide näitus Arhitektuuri- ja Disainigaleriis 18. IX-1. X. Disaini osalusest tänases tootmissüsteemis ja asendist kultuurisüsteemis. Taimi Soo1972. a. ruumiinstallatsiooni restauratsioonist

04 John 03.pmd

African Journals Online (AJOL)

Owner

29 Jul 2010 ... prys aan Melanie Grobler toegeken het vir dié bundel. Vanuit 'n juridiese perspektief lyk die heftige reaksies van literêre kritici, skrywers en uitgewers egter grootliks onnodig en oorbodig, soos duidelik blyk uit 'n onlangse regsproefskrif oor kopieregskending wat juis episodes uit die Afrikaanse letterkunde.

Mitigating crystallization of saturated FAMEs in biodiesel 6: The binary phase behavior of 1, 2-dioleoyl-3-stearoyl sn-glycerol – Methyl stearate

International Nuclear Information System (INIS)

Mohanan, Athira; Bouzidi, Laziz; Narine, Suresh S.

2016-01-01

The derivatives of vegetable oils with specific chemical structures, such as TAG (triacylglycerols) having mixed straight and kinked moieties, have proven very effective in lowering the crystallization of biodiesel. SOO (1, 2-dioleoyl-3-stearoyl sn-glycerol)/MeS (methyl stearate) is part of a series of studies of TAG/FAME (fatty acid methyl ester) binary model systems conducted to establish structure–function relationships of lipid-based cold flow improvers in biodiesel with a particular attention to the effect of molecular symmetry in contrast with a previously published study of the OSO (1, 3-dioleoyl-2-stearoyl sn-glycerol)/MeS binary system. The phase behavior of several SOO/MeS mixtures were investigated at different length scales with XRD (X-ray diffraction), DSC (differential scanning calorimetry) and PLM (polarized light microscope). A complete phase diagram including the transformation lines, crystal structure and microstructure was constructed. The solubility behavior was discussed using a simple thermodynamic model based on the Hildebrand equation and pair interactions. The asymmetric position of the oleic moieties of SOO was shown to be crucial in modifying the thermal transformation behavior of MeS. The findings may be used to design effective crystallization modifiers of biodiesel based on particular structural determinants, and underscores the importance of symmetry in such designs. - Highlights: • Effect of symmetry of triglyceride on biodiesel crystallization established. • Complete phase diagram of model triacylglycerol/biodiesel binary system achieved. • Correlation between thermal transitions, crystal structure and microstructure revealed. • Transformation points useful for improving the cold flow of biodiesel identified. • Necessary knowledge gathered to design effective biodiesel cold flow improvers.

In situ crystallization and transformation kinetics of polymorphic forms of saturated-unsaturated-unsaturated triacylglycerols: 1-palmitoyl-2,3-dioleoyl glycerol, 1-stearoyl-2,3-dioleoyl glycerol, and 1-palmitoyl-2-oleoyl-3-linoleoyl glycerol.

Science.gov (United States)

Bayés-García, L; Calvet, T; Cuevas-Diarte, M A; Ueno, S

2016-07-01

We examined the influence of dynamic thermal treatment (variation of cooling/heating rates) on the polymorphic crystallization and transformation pathways of 1-palmitoyl-2,3-dioleoyl glycerol (POO), 1-stearoyl-2,3-dioleoyl glycerol (SOO), and 1-palmitoyl-2-oleoyl-3-linoleoyl glycerol (POL), which are major saturated-unsaturated-unsaturated (SUU) triacylglycerols (TAGs) of vegetable oils and animal fats (e.g., palm oil, olive oil, and Iberian ham fat). Using mainly a combination of differential scanning calorimetry (DSC) and synchrotron radiation X-ray diffraction (SR-XRD), we analyzed the polymorphic behavior of TAGs when high (15°Cmin -1 ), intermediate (2°Cmin -1 ), and low (0.5°Cmin -1 ) cooling and heating rates were applied. Multiple polymorphic forms were detected in POO, SOO, and POL (sub-α, α, β' 2 , and β' 1 ). Transient disordered phases, defined as kinetic liquid crystal (KLC) phases, were determined in POO and SOO for the first time. The results demonstrated that more stable forms were directly obtained from the melt by decreasing the cooling rates, whereas less stable forms predominated at high cooling rates, as confirmed in our previous work. Regarding heating rate variation, we confirmed that the nature of the polymorphic transformations observed (solid-state, transformation through KLC phase, or melt-mediation) depended largely on the heating rate. These results were discussed considering the activation energies involved in each process and compared with previous studies on TAGs with different saturated-unsaturated structures (1,3-dioleoyl-2-palmitoylglycerol, 1,3-dipalmitoyl-2-oleoyl-glycerol, trioleoyl glycerol, and 1,2-dioleoyl-3-linoleoyl glycerol). Copyright © 2016 Elsevier Ltd. All rights reserved.

A MODULAR DESIGN OF A WALL-CLIMBING ROBOT AND ITS MECHATRONICS CONTROLLER

Directory of Open Access Journals (Sweden)

N.S. Tlale

2012-01-01

Full Text Available

ENGLISH ABSTRACT: The modular design of a wall-climbing robot, implementing two articulated legs per module (biped robotic modules, is presented in this paper. Modular design improves a wall-climbing robot’s manoeuvrability and flexibility during surface changes or while walking on uneven surfaces. The design of the articulated legs uses four motors to control the posture of the vacuum cups, achieving the best possible contact with the surface. Each leg can contain more than five sensors for effective feedback control, and additional sensors such as gyros, CCD sensors, etc, can be fitted on a module, depending on the robot’s application. As the number of modules used in the design of the robot is increased, the number of actuators and sensors increases exponentially. A distributed mechatronics controller of such systems is presented.

AFRIKAANSE OPSOMMING: Modulêre ontwerp van 'n muurklim-robot met twee geskarnierde bene per module (twee-benige robotmodules word in hierdie artikel weergegee. Modulêre ontwerp verbeter die muurklim-robot se beweeglikheid en aanpasbaarheid tydens veranderings in die loopvlak of terwyl dit loop op ongelyke oppervlaktes. Ontwerp van geskarnierde bene implementeer vier motors wat die oriëntasie van vakuumsuigdoppe beheer om die bes moontlike kontak met die loopvlak te handhaaf. Elke been kan meer as vyf sensors hê vir doeltreffende terugvoerbeheer, en bykomende sensors soos giroskope, CCD sensors, ens. kan by 'n module gevoeg word soos die toepassing van die robot dit mag vereis. Soos die aantal modules wat in die ontwerp van die robot gebruik word, toeneem, neem die aantal aktiveerders en sensors eksponensiëel toe. 'n Verdeelde megatroniese beheerder van sulke stelsels word aangebied.

Internal Audit Service | Internal Audit Service

Science.gov (United States)

their internal auditing function in the areas of professional excellence, quality of service and Students and teachers Media Internal Audit Service Navbar Toggle Home About the Staff Risk Assessment and Planning Internal Audit Process Search for Search Home The mission of the Fermilab Internal Audit Service

Generation of CRISPR/Cas9-mediated bicistronic knock-in ins1-cre driver mice.

Science.gov (United States)

Hasegawa, Yoshikazu; Hoshino, Yoshikazu; Ibrahim, Abdelaziz E; Kato, Kanako; Daitoku, Yoko; Tanimoto, Yoko; Ikeda, Yoshihisa; Oishi, Hisashi; Takahashi, Satoru; Yoshiki, Atsushi; Yagami, Ken-Ichi; Iseki, Hiroyoshi; Mizuno, Seiya; Sugiyama, Fumihiro

2016-07-29

In the present study, we generated novel cre driver mice for gene manipulation in pancreatic β cells. Using the CRISPR/Cas9 system, stop codon sequences of Ins1 were targeted for insertion of cre, including 2A sequences. A founder of C57BL/6J-Ins1(em1 (cre) Utr) strain was produced from an oocyte injected with pX330 containing the sequences encoding gRNA and Cas9 and a DNA donor plasmid carrying 2A-cre. (R26GRR x C57BL/6J-Ins1(em1 (cre) Utr)) F1 mice were histologically characterized for cre-loxP recombination in the embryonic and adult stages; cre-loxP recombination was observed in all pancreatic islets examined in which almost all insulin-positive cells showed tdsRed fluorescence, suggesting β cell-specific recombination. Furthermore, there were no significant differences in results of glucose tolerance test among genotypes (homo/hetero/wild). Taken together, these observations indicated that C57BL/6J-Ins1(em1 (cre) Utr) is useful for studies of glucose metabolism and the strategy of bicistronic cre knock-in using the CRISPR/Cas9 system could be useful for production of cre driver mice.

Field implementation of fiber-reinforced polymer (FRP) deck panels.

Science.gov (United States)

2017-06-01

Jeffery S. Volz, S.E., P.E., Ph.D., Kamal H. Khayat, PhD, P.Eng. http://orcid.org/0000-0003-1431-0715, Soo Duck Hwang, Ph.D. http://orcid.org/0000-0003-2178-1531, Hesham Tuwair, Ph.D., Jonathan T. Drury, Amy S. Crone : Although still in their infancy...

Tallinna kultuuriväärtuste ameti tunnustused

Index Scriptorium Estoniae

2014-01-01

Parimatest restaureeritud mälestistest: Pagari 1, Raua 39, Õllepruuli 5, Allika 4, Kooli 9, Rahukohtu 5, Toom-Kooli 21, Toompuiestee 24. Parimatest restaureeritud majadest Tallinna miljööaladel: Köie 3, Soo 42, Vabriku 10, Kentmanni 18, Loode 14, Ristiku 4B, Sõbra 20, Valgevase 12, Wiedemanni 11

Siektes van peroksisome - 'n oorsig

African Journals Online (AJOL)

(x 14 SOO). Peroksisoomsiektes2. ,3,5.6. Ongeveer 12 genetiese siektes wat as gevolg van foute in die ontwikkeling of in die samestelling van peroksisome antstaan, is reeds beskryf. Volgens die omvang van die biogenetiese fout en die graad van verlies aan peroksisoomfunksies word hierdie sindrome in 3 groepe.

Die terapeutiese imperatief, stories en letterkunde: 'n Repliek aan ...

African Journals Online (AJOL)

27 Jan 2006 ... mense soos Abraham Maslow en Carl Rogers wat “self-verwerkliking” tot doelwit verhef het. Die soort individu wat sentraal staan in die ego-sielkunde verskil hemelsbreed van die individu kenmerkend van die Freudiaanse en Lacaniaanse psigoanalise. Die individu wat in hul benadering verskyn, is altyd ...

Nooruslik kaupmeheemand kavatseb äri laiendada / Hille Tänavsuu

Index Scriptorium Estoniae

Tänavsuu, Hille, 1941-2014

2006-01-01

Vt. ka Postimees : na russkom jazõke 23. märts lk. 8. Tallinnas Vana-Kalamaja tänaval paikneva Alma Äri omanik Alma Sooäär avas oma esimese poe enam kui 15 aastat tagasi Nõmmel, praegu plaanib poeomanik majapidamistarvete äri laiendamist. Kaart: Alma Äri

biologie -onderwys vir die mens en sy omgewing?: 'n kritiese ...

African Journals Online (AJOL)

stimulus to learn more of nature has become a dreary drudge, a mountain of indigestible facts, however vaLid. (Milstein 1984) . . • Biology teachers are becoming dinosaurs in a changing environment. (Frazier 1984). Uitsprake soos die enkele voorbeelde wat hier aan- gehaal is~ verskyn in toenemende mate in meer res-.

Deon Meyer

African Journals Online (AJOL)

Owner

of ten minste gekontekstualiseer, word. By die gastehuis, La Petite Margaux, is daar drie lyke met drie perfekte kopskote. Twee van die oorledenes is militêre tipes, oud-SAPD- lyfwagte wat as persoonlike sekuriteitswagte vir Jeanette Louw, besturende direkteur van. Body Armour (soos in Onsigbaar en 7 dae), ge- werk het.

Jazz festival offers mellow way to get into festive spirit / Aleksei Gunter

Index Scriptorium Estoniae

Gunter, Aleksei, 1979-

2003-01-01

Aafrika laulja Malia kontserdist Sakala keskuses 9. dets.; Jaak Sooääre ja taani kitarristi Pierre Dorge kontserdist Tallinna kunstihoones 4. dets.; Hedvig Hansoni ja Andre Maakeri kontserdist Niguliste kirikus 11. dets.; ameerika ansambli Gold Company Sextet kontsertidest Tallinnas 14. dets. ja Pärnus 15. dets. festivali Jõulujazz raames

die doeltreffendheid van die afrikaanse woordelys en spelreels

African Journals Online (AJOL)

sluiting by die reel vir die verdubbeling van medeklinkers na 'n kort, be- klemtoonde klinker, woorde soos ballet, ballon, terras, terrein, dissipel en dissipline slegs met een konsonant na die eerste vokaal gespel moes word, omdat daardie voorafgaande vokaal onbeklemtoon is. Ook hierdie uit- sondering op die reel word ...

Resource-Efficient Data-Intensive System Designs for High Performance and Capacity

Science.gov (United States)

2015-09-01

76, 79, 80, and 81.] [9] Anirudh Badam, KyoungSoo Park, Vivek S. Pai, and Larry L. Peterson. HashCache: cache storage for the next billion. In Proc...Jeffrey Dean, Sanjay Ghemawat, Wilson C. Hsieh, Deborah A. Wallach, Mike Burrows , Tushar Chandra, Andrew Fikes, and Robert E. Gruber. Bigtable: A

Invloed van intravaginale progestagene op estrusaktiwiteit by ...

African Journals Online (AJOL)

geneem: Een maal per dag vanaf 2 dae voor tot 4 dae na sponsinplasing, gevolg deur een maal per dag tot die aanvang van estrus en daarna sesuurliks tot aan die einde van die estrusperiode. Progesteroon- en LH- konsentrasie is bepaal volgens radio-immunologiese tegnieke soos onderskeidelik beskryf is deur Faure.

Influence and Interest: How a Belligerent Dictator Resists Current Methods

Science.gov (United States)

2018-04-09

on China. The administration has done this through sanctions on a “Chinese bank for allegedly laundering money for North Korea.”32 Sanctions... money to their military programs and employ external aid to provide for the basic needs of the people. Additionally, the Kim Regine utilizes brutal...was lost with the collapse of the Soviet Union. North Korea utilized internal money for those military programs, leaving few financial resources to

Pramana – Journal of Physics | Indian Academy of Sciences

Indian Academy of Sciences (India)

... J Jia B M Johnson S C Johnson K S Joo S Kametani J H Kang M Kann S S Kapoor S Kelly B Khachaturov A Khanzadeev J Kikuchi D J Kim H J Kim S Y Kim Y G Kim W W Kinnison E Kistenev A Kiyomichi C Klein-Boesing S Klinksiek L Kochenda V Kochetkov D Koehler T Kohama D Kotchetkov A Kozlov P J Kroon K Kurita ...

Analysis of zinc oxide nanoparticles binding proteins in rat blood and brain homogenate

Directory of Open Access Journals (Sweden)

Shim KH

2014-12-01

Full Text Available Kyu Hwan Shim,1 John Hulme,1 Eun Ho Maeng,2 Meyoung-Kon Kim,3 Seong Soo A An1 1Department of Bionano Technology, Gachon Medical Research Institute, Gachon University, Sungnam-si, Gyeonggi-do, South Korea; 2Department of Analysis, KTR, Kimpo, Gyeonggi-do, South Korea; 3Department of Biochemistry and Molecular Biology, Korea University Medical School and College, Seoul, South Korea Abstract: Nanoparticles (NPs are currently used in chemical, cosmetic, pharmaceutical, and electronic products. Nevertheless, limited safety information is available for many NPs, especially in terms of their interactions with various binding proteins, leading to potential toxic effects. Zinc oxide (ZnO NPs are included in the formulation of new products, such as adhesives, batteries, ceramics, cosmetics, cement, glass, ointments, paints, pigments, and supplementary foods, resulting in increased human exposures to ZnO. Hence, we investigated the potential ZnO nanotoxic pathways by analyzing the adsorbed proteins, called protein corona, from blood and brain from four ZnO NPs, ZnOSM20(-, ZnOSM20(+, ZnOAE100(-, and ZnOAE100(+, in order to understand their potential mechanisms in vivo. Through this study, liquid chromatography–mass spectroscopy/mass spectroscopy technology was employed to identify all bound proteins. Totals of 52 and 58 plasma proteins were identified as being bound to ZnOSM20(- and ZnOSM20(+, respectively. For ZnOAE100(- and ZnOAE100(+, 58 and 44 proteins were bound, respectively. Similar numbers of proteins were adsorbed onto ZnO irrespective of size or surface charge of the nanoparticle. These proteins were further analyzed with ClueGO, a Cytoscape plugin, which provided gene ontology and the biological interaction processes of identified proteins. Interactions between diverse proteins and ZnO nanoparticles could result in an alteration of their functions, conformation, and clearance, eventually affecting many biological processes. Keywords: brain

The genetics of Alzheimer's disease

Directory of Open Access Journals (Sweden)

Bagyinszky E

2014-04-01

Full Text Available Eva Bagyinszky,1 Young Chul Youn,2 Seong Soo A An,1,* SangYun Kim3,*1Department of BioNano Technology Gachon University, Gyeonggi-do, 2Department of Neurology, Chung-Ang University College of Medicine, Seoul, 3Department of Neurology, Seoul National University Budang Hospital, Gyeonggi-do, South Korea*These authors contributed equally to this workAbstract: Alzheimer's disease (AD is a complex and heterogeneous neurodegenerative disorder, classified as either early onset (under 65 years of age, or late onset (over 65 years of age. Three main genes are involved in early onset AD: amyloid precursor protein (APP, presenilin 1 (PSEN1, and presenilin 2 (PSEN2. The apolipoprotein E (APOE E4 allele has been found to be a main risk factor for late-onset Alzheimer's disease. Additionally, genome-wide association studies (GWASs have identified several genes that might be potential risk factors for AD, including clusterin (CLU, complement receptor 1 (CR1, phosphatidylinositol binding clathrin assembly protein (PICALM, and sortilin-related receptor (SORL1. Recent studies have discovered additional novel genes that might be involved in late-onset AD, such as triggering receptor expressed on myeloid cells 2 (TREM2 and cluster of differentiation 33 (CD33. Identification of new AD-related genes is important for better understanding of the pathomechanisms leading to neurodegeneration. Since the differential diagnoses of neurodegenerative disorders are difficult, especially in the early stages, genetic testing is essential for diagnostic processes. Next-generation sequencing studies have been successfully used for detecting mutations, monitoring the epigenetic changes, and analyzing transcriptomes. These studies may be a promising approach toward understanding the complete genetic mechanisms of diverse genetic disorders such as AD.Keywords: dementia, amyloid precursor protein, presenilin 1, presenilin 2, APOE, mutation, diagnosis, genetic testing

International Trade. International Business

OpenAIRE

Мохнюк, А. М.; Mokhniuk, A. M.

2015-01-01

Work programme of the study course “International Trade. International Business” was prepared in accordance with educational and vocational training program for bachelors of training direction 6.030601 “Management”.

Electric Power Research in 1991

International Nuclear Information System (INIS)

1991-05-01

This book of contents are a study of desalination by Kim, Young Bu, a study on efficiency test for nuclear power security by Jo, Sung Je; Ann, Nam Sung; Kim, Ho Gi, augmentation of EMS and RYU by Jung, Tae Hoe; Shin, Young Chuel, research on application for electric cars by Yu, Ann Gue, practical use oft robot for nuclear industry by Woo, He Gone; Shin, Hen Beom, a study on the characteristics of coolant structure in generator by Choi, Beng Hwan; Song, Young Chel; Kim, Jong Hark, and research of penetration rate of appliances by Park, Hong Ho; Kim, Beng Cheal; Kim, Dong Hwen.

Natural course of early COPD

Directory of Open Access Journals (Sweden)

Rhee CK

2017-02-01

Full Text Available Chin Kook Rhee,1 Kyungjoo Kim,1 Hyoung Kyu Yoon,2 Jee-Ae Kim,3 Sang Hyun Kim,4 Sang Haak Lee,5 Yong Bum Park,6 Ki-Suck Jung,7 Kwang Ha Yoo,8 Yong Il Hwang7 1Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Seoul St Mary’s Hospital, 2Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Yeouido St Mary’s Hospital, College of Medicine, The Catholic University of Korea, Seoul, 3Pharmaceutical Policy Evaluation Research Team, Research Institution, 4Big Data Division, Health Insurance Review and Assessment Service, Wonju, 5Division of Pulmonary, Critical Care and Sleep Medicine, Department of Internal Medicine, St Paul’s Hospital, College of Medicine, The Catholic University of Korea, 6Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Internal Medicine, Hallym University Kangdong Sacred Heart Hospital, Seoul, 7Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang, 8Division of Pulmonary, Allergy and Critical Care Medicine, Department of Internal Medicine, Konkuk University School of Medicine, Seoul, Republic of Korea Background and objective: Few studies have examined the natural course of early COPD. The aim of this study was to observe the natural course of early COPD patients. We also aimed to analyze medical utilization and costs for early COPD during a 6-year period. Methods: Patients with early COPD were selected from Korean National Health and Nutrition Examination Survey (KNHANES data. We linked the KNHANES data of patients with early COPD to National Health Insurance data. Results: A total of 2,397 patients were enrolled between 2007 and 2012. The mean forced expiratory volume in 1 second (FEV1 was 78.6%, and the EuroQol five dimensions questionnaire (EQ-5D index value was 0.9. In total, 110 patients utilized health

Piezoelectric Nanogenerators for Self-Powered Nanosystems and Nanosensors

Science.gov (United States)

2013-05-15

researchers 1. Sangmin Lee, Sung-Hwan Bae, Long Lin, Seunghyun Ahn, Chan Park, Seung Nam Cha, Young Jun Park, Hyuk Chang, Sang-Woo Kim and...Sohn, Seung Nam Cha, Dukhyun Choi * Zhong Lin Wang * Sang-Woo Kim * “ P-Type Polymer–Hybridized High-Performance Piezoelectric Nanogenerators”, Nano...Yoon Lee, † Sang-Woo Kim , *,$ Jae-Young Choi, *,† Jong Min Kim , † and Zhong Lin Wang *, “Flexible Hybrid Multi-Type Energy Scavenger”, Energy

Health benefits of soy beans and soy products: a review | Venter ...

African Journals Online (AJOL)

Heel sojabone bevat 40% proteïene, terwyl sojameel, sojaproteïenkonsentraat en geïsoleerde sojaproteïen respektiewelik 50%, 70% en 90% proteïen bevat. Verskeie nie-nutriëntbestanddele soos isoflavone, protease-inhibeerders, fitiensuur, saponiene en fitosterole kom in sojabone voor en is moontlik vir sekere van die ...

Twee aardbewings of een? Die assosiasie van literêre motiewe in ...

African Journals Online (AJOL)

Net soos in die Matteus-evangeiie self, is hier geen duidelike aanduiding van 'n on- derlinge verband tussen die aardbewing en die ander verskynsels wat vermeld word nie. Sintaktiese merkers ontbreek, want die passasie bevat bloot vier frases wat asindeties op mekaar volg, plus een frase wat met 'n neweskikkende Kai ...

Luuleõhtu "Sitikas suudleb kuud"

Index Scriptorium Estoniae

2009-01-01

29. okt. toimub Adamson-Ericu muuseumis luuleõhtu, kus esinevad Andres Ehin luule ja häälutustega, Mart Soo kitarril ja Brian Melvin löökriistadel. Üritus toimub Kōkyō Hatanaka (sünd. 1947) näituse "Aasia minu südames. Jaapani klassikaline maal nihonga" raames

LANGUAGE IN MILITARY SERVICE

African Journals Online (AJOL)

Vanaf sy stigting in 1912 tot vandag het doeltreffende taalgebruik in beide amptelike voertale 'n hoofrol gespeel en die rol is selfs verskans in die bepalings vim Artikel137 van die Verdedigingswet. 1957, soos gewysig. Hiervolgens is gelykberegtiging van die beide amptelike voertaJe die SAW se beleid. Die voertaJe in ...

Bleek planeet

African Journals Online (AJOL)

Owner

king”) en verskynsels soos el niño word be- trek. Aardverwoesting, natuurverskynsels en die geïmpliseerde rol van die mens as (dikwels gefaalde) behoeder van die natuur word in hierdie bundel met deurdagte en suggestie- ryke taal onder woorde gebring. In Bleek planeet werk heelwat van die ge- digte intertekstueel.

Vana mõisahoone ärkas elule / Heli Salong

Index Scriptorium Estoniae

Salong, Heli, 1958-

2008-01-01

Muhus asuva Pädaste mõisa peahoone avamist tähistati kultuuriprogrammiga. Kohal viibisid ka president Toomas Hendrik Ilves ja proua Evelin Ilves. Juuresoleval fotol Muhu kooliõpetaja Tiina Saar, mõisaomanikud Martin Breuer ja Imre Sooäär ning proua Evelin Ilves härrastemaja linti läbi lõikamas

Kas tüdrukud jõuavad järele? Soolise infokihistumise arengujoontest Eestis / Veronika Kalmus

Index Scriptorium Estoniae

Kalmus, Veronika, 1973-

2004-01-01

Sugudevahelistest erinevustest infotehnoloogia kasutamises ning olulise informatsiooni valdamises. 14-19-aastaste noorte seas tehtud küsitlusuuringute tulemustest. Diagrammid: Internetiühenduse olemasolu kodus (%); Interneti märkimisväärne kasutamine (%); Arvutikasutusoskuste keskmised enesehinnangud. Tabelid: Infokihistumise aspektid soo lõikes vanuserühmades 2002-03. a.; Lineaarse regressioonanalüüsi tulemused

Ekwivalentverhoudings in tweetalige woordeboeke: implikasies vir ...

African Journals Online (AJOL)

user

twee maal homonimies en ook twee maal polisemies is nie — dit word ook nie van die gebruiker verwag nie. Die betekeniswaardes vir "lig" word dus nie soos in algemene tweetalige woordeboeke van getalle in boskrif voorsien om homo- nieme te onderskei nie, en ook nie van Romeinse syfers om polisemiese beteke-.

"DE KAT"

African Journals Online (AJOL)

was die sivetkatte van besondere belang in ver- band met die vervaardiging van parfuum. Sivet- katte wat in gevangeskap aangehou is, kon twee maal per week van hulle reukstof ontdoen word.(14). Daar was dus, soos uit die vermelde besonder- hede duidelik blyk, geen verband tussen die eersgenoemde kat of cavalier ...

Die gebruik van 'n handpop as mede- terapeut en 'n vyfjarige ...

African Journals Online (AJOL)

p1243322

waarmee Billy Beer werk en elemente soos humor en herhaling word gebruik om ouderdomstoepaslik teenoor haar te reageer en op so manier haar unieke. “taal” te praat. In die res van die artikel word eerstens aandag gegee aan sake van 'n metodologiese aard, insluitende die gebruik van die sentrale metafoor van 'n.

Comment on "Combination of cupric ion with hydroxylamine and hydrogen peroxide for the control of bacterial biofilms on RO membranes by Hye-Jin Lee, Hyung-Eun Kim, Changha Lee [Water Research 110, 2017, 83-90]".

Science.gov (United States)

Chen, Long; Peng, Ying; Tang, Min; Wu, Feng

2017-07-01

The methodology employed by Lee et al. to terminate their bactericidal assays was found to be flawed via our demonstrations. Briefly, EDTA or sulfite combining with cupric ion did not fully terminate, and instead even boosted the P. aeruginosa death. We therefore suggested them to seek for other means of reaction termination, such as the combination of buffering agent PBS and Cu(II)-complexing agent EDTA. Copyright © 2017 Elsevier Ltd. All rights reserved.

Journal of EEA, Vol. 25, 2008

African Journals Online (AJOL)

FACE RECOGNITION USING ARTIFICIAL NEURAL NETWORK. Sentayehu Endeshaw and .... Number of statistical and Artificial Intelligence techniques have been ..... college publishing company, Newyork, 1994. [4] Hyun Jin Park and Hyun ...

Brassia campestris L. ssp. chinensis L.var. utilis Tsen et Lee

African Journals Online (AJOL)

omodibo

2012-12-31

Dec 31, 2012 ... On the basis of morphological and cultural features, the pathogen ... Alternaria isolate from Purple-Caitai showed 99% identity with other ITS sequences of .... Cho KH, Park SH, Kim KT, Kim S, Kim JS, Park BS, Woo JG, Lee HJ.

First results from RHIC-PHENIX£

Indian Academy of Sciences (India)

S C Johnson,. Ѕѕ. K S Joo, ѕї. S Kametani,. ½. J H Kang,. ¿. M Kann, їј. S S Kapoor,. ¾. S Kelly, B Khachaturov,. ¾. A Khanzadeev, їј. J Kikuchi,. ½. D J Kim,. ¿. H J Kim,. ¿. S Y Kim,. ¿. Y G Kim,. ¿. W W Kinnison,. ½. E Kistenev,. ¿. A Kiyomichi,. ¿. C Klein-Boesing, ѕѕ. S Klinksiek,. ¾. L Kochenda, їј. D Kochetkov, V Kochetkov,.

Presence of sarcopenia in asthma–COPD overlap syndrome may be a risk factor for decreased bone-mineral density, unlike asthma: Korean National Health and Nutrition Examination Survey (KNHANES IV and V (2008–2011

Directory of Open Access Journals (Sweden)

Lee DW

2017-08-01

Full Text Available Dong-Won Lee,1 Hyun-Jung Jin,2 Kyeong-Cheol Shin,2 Jin-Hong Chung,2 Hyoung-Woo Lee,3 Kwan-Ho Lee2 1Division of Pulmonology, Department of Internal Medicine, Andong Sungso Hospital, Andong, 2Division of Pulmonology and Allergy, 3Division of Endocrinology, Department of Internal Medicine, Yeungnam University Hospital, Daegu, South Korea Background: Sarcopenia and decreased bone-mineral density (BMD are common in elderly people, and are major comorbidities of obstructive airway disease (OAD. However, the relationship between sarcopenia and BMD in each OAD phenotype, especially asthma–COPD overlap syndrome (ACOS, is not yet clear. We aimed to evaluate differences in BMD according to the presence of sarcopenia in each OAD phenotype. Materials and methods: Among the research subjects in KNHANES IV and V (2008–2011, 5,562 were ≥50 years old and underwent qualified spirometry and dual-energy X-ray absorptiometry. A total of 947 subjects were included in the study: 89 had asthma, 748 COPD, and 110 ACOS. Results: In the COPD and ACOS phenotypes, T-scores were lower in the sarcopenia group than the nonsarcopenia group. Prevalence rates of osteopenia and osteoporosis were higher in the sarcopenia group than the nonsarcopenia group. (P<0.001 and P=0.017, respectively. The sarcopenia group had higher risks of developing osteopenia, osteoporosis, and low BMD than the nonsarcopenia group in the ACOS phenotype (OR 6.620, 95% CI 1.129–38.828 [P=0.036], OR 9.611, 95% CI 1.133–81.544 [P=0.038], and OR 6.935, 95% CI 1.194–40.272 [P=0.031], respectively. However, in the asthma phenotype, the sarcopenia group showed no increased risk compared with the nonsarcopenia group. Conclusion: In the ACOS phenotype, individuals with sarcopenia had a higher prevalence rate and higher risks of osteopenia and osteoporosis than those without sarcopenia among all OAD phenotypes. Keywords: asthma, chronic obstructive pulmonary disease, asthma–COPD overlap syndrome

Provenance and indirect dating study on Hongzhou Kiln porcelains by INAA

International Nuclear Information System (INIS)

Feng, X.Q.; Feng, S.L.; Quan, K.S.

2007-01-01

Over 100 sherds were collected from Hongzhou Kiln of Jiangxi Province, China and their body samples were analyzed by INAA. The compositional differences between samples with the same period but different provenance were observed. The contents of Na, Rb, Ba, Fe, Th, U, etc., were found to be different among samples from different periods, which implies they may be used to identify the manufacturing age indirectly. The analytical data were further processed by principal components analysis (PCA). The statistical results show that all the sherds can be classified into 5 groups: (1) Eastern Han and Eastern Wu; (2) Western Jin, Eastern Jin and Southern Dynasties; (3) Sui; (4) Early Tang and Middle Tang; (5) Late Tang and Five Dynasties. (author)

Evaluation of silica nanoparticle toxicity after topical exposure for 90 days

Directory of Open Access Journals (Sweden)

Ryu HJ

2014-12-01

Full Text Available Hwa Jung Ryu,1,* Nak-won Seong,2,* Byoung Joon So,1 Heung-sik Seo,2 Jun-ho Kim,2 Jeong-Sup Hong,2 Myeong-kyu Park,2 Min-Seok Kim,2 Yu-Ri Kim,3 Kyu-Bong Cho,4 Mu yeb Seo,2 Meyoung-Kon Kim,3 Eun Ho Maeng,2 Sang Wook Son1 1Department of Dermatology, Korea University College of Medicine, Seoul, South Korea; 2Korea Testing and Research Institute, Gyunggi-Do, South Korea; 3Department of Biochemistry and Molecular Biology, Korea University College of Medicine, Seoul, South Korea; 4Department of Clinical Laboratory Science, Shinheung College, Uijeongbu, South Korea *These authors contributed equally to this work Abstract: Silica is a very common material that can be found in both crystalline and amorphous forms. Well-known toxicities of the lung can occur after exposure to the crystalline form of silica. However, the toxicities of the amorphous form of silica have not been thoroughly studied. The majority of in vivo studies of amorphous silica nanoparticles (NPs were performed using an inhalation exposure method. Since silica NPs can be commonly administered through the skin, a study of dermal silica toxicity was necessary to determine any harmful effects from dermal exposures. The present study focused on the results of systemic toxicity after applying 20 nm colloidal silica NPs on rat skin for 90 days, in accordance with the Organization for Economic Cooperation and Development test guideline 411 with a good laboratory practice system. Unlike the inhalation route or gastrointestinal route, the contact of silica NPs through skin did not result in any toxicity or any change in internal organs up to a dose of 2,000 mg/kg in rats. Keywords: silica nanoparticles, toxicity, dermal route

Kimi mantlipärija sai mõjukatele ametipostidele / Kaivo Kopli

Index Scriptorium Estoniae

Kopli, Kaivo

2010-01-01

Põhja-Korea pealinnas toimunud Tööliste Partei kongressil määrati riigi liidri Kim Jong-ili noorim poeg Kim Jong-un kesksõjakomisjoni aseesimeheks ja keskkomitee liikmeks. Poliitbüroosse määrati alternatiivliikmena Kim Jong-ili õe abikaasa Chang Song-taek

Water Quality Evaluation of PET Bottled Water by Mineral Balance in the Northeast Asian Region: A Case Study of South Korea.

Science.gov (United States)

Houri, Daisuke; Koo, Chung Mo

2015-09-01

The past few years have seen a demand for drinking water in contemporary society with a focus on safety and taste. Mineral water is now marketed as a popular commercial product and, partly due to health concerns, the production. For the study, a comparison was carried out of water samples from 9 types of polyethylene terephthalate (PET) bottled water sold in South Korea as well as from tap water in the cities of Seoul and Chuncheon. These were compared with samples of Japanese PET bottled water in order to determine shared commonalities and identify individual characteristics. To evaluate water quality objectively, we quantified the elements contained in the water samples. Samples were assessed not with the usual sensory evaluation but with the evaluation approach advocated by Hashimoto et al. which employs the Water Index of Taste and the Water Index of Health. The levels of water quality obtained were compared with the "Prerequisites for Tasty Water" and the "Standards for Tasty Water" devised for city water. The PET Bottled water varieties analyzed in this study-Seoksu, Icis, Bong Pyong, Soon Soo 100, Dong Won Saem Mul, GI JANG SOO and DIAMOND-showed the Water Index of Taste ≥ 2.0 and the Water Index of Health ≥ 5.2, which we classified as tasty/healthy water. SamDaSoo and NamiNeral can be classified as tasty water due to their values of the Water Index of Taste ≥ 2.0 and the Water Index of Health water studied here fulfills the "Water Index of Taste," "Water Index of Health," "Standard for Tasty Water" and "Prerequisites for Tasty Water" that Japanese people value for city water. We can conclude that bottled water which meets water quality requirements will be considered good-tasting by a majority of people.

Total Gastric Necrosis: A Case Report and Literature Review

African Journals Online (AJOL)

2017-05-22

123 beats/min) with atrial fibrillation, and suspicious abdominal tenderness with positive shifting dullness. B-ultrasonography of the abdomen showed peritoneal ascites, and diagnostic abdominal paracentesis. G Huang, Y Jin1.

Effects of calcium impurity on phase relationship, ionic conductivity ...

Indian Academy of Sciences (India)

Home; Journals; Bulletin of Materials Science; Volume 39; Issue 3. Effects of calcium impurity on phase relationship, ionic conductivity and microstructure of Na + - β / b e t a " -alumina solid electrolyte. SUNG-TAE LEE DAE-HAN LEE SANG-MIN LEE SANG-SOO HAN SANG-HYUNG LEE SUNG-KI LIM. Volume 39 Issue 3 ...

Journal of Genetics | Indian Academy of Sciences

Indian Academy of Sciences (India)

The effect of high glucose levels on the hypermethylation of protein phosphatase 1 regulatory subunit 3C (PPP1R3C) gene in colorectal cancer. Soo Kyung ... DNA methylation is an epigenetic event that occurs frequently in colorectal cancer (CRC). ... The expression of PPP1R3C was inversely related to methylation status.

n narratiewe benadering tot die pastoraat: kritiese opmerkings na ...

African Journals Online (AJOL)

deur Carl Rogers bekend gemaak is en wat verder in die pastoraat ontgin is deur pastorale teoloë soos Wayne Oates, Paul Johnson en Carrol Wise. (De Jongh van Arkel 1988:2). Hierdie assimilering het egter beteken dat die aanspraak van die Woord nou ondergeskik aan die behoeftes van die persoon in beraad geword ...

Tammsaare ja piltlugu

Index Scriptorium Estoniae

2006-01-01

Anton Hansen Tammsaare muuseumi korraldatud koomiksivõistlusest "Teistmoodi Tammsaare", žürii koosseis. Esimese koha pälvis Joonas Sildre koomiks "Kuningal on külm", teise koha Elina Sildre töö "Koolis", kolmanda koha soomlase Jyrki Heikkineni töö "Soo peal". Kommenteerivad Tõnu Kaalep, Maarja Lõhmus, Ivar Laus, Meelik Mallene, Mari Laaniste

Naised põllumajanduses = Women in agriculture / Aili Maanso

Index Scriptorium Estoniae

Maanso, Aili

2006-01-01

2005. a. struktuuriuuringu andmetel oli Eesti ligi 28 000 põllumajanduslikus majapidamises 90 850 hõivatut. Püsitööjõust (peretööjõud ja alalised töötajad) oli mehi 51,1% ja naisi 48,9%, 37% majapidamistest oli naisjuht. Majapidamiste juhid soo ja vanuse järgi. Tabelid

Jazz-muusikud tulevad kevadet tooma / Silja Joon

Index Scriptorium Estoniae

Joon, Silja, 1966-

2009-01-01

Pärnus Jazzkaare festivalil esinejatest: norra laulja Solveig Slettahjell 19. aprillil Eliisabeti kirikus, Hedvig Hanson kontserdiga "Rahvaste hällilaulud" 21. apr. Pärnu kontserdimajas, duo Jaak Sooäär - Tuule Kann 22. apr. Pärnu raekojas ja Andy Emleri trio 23. apr. Ammende villas. Jazzkaare festivali ajaloost korraldaja Anne Ermi sõnul

Portrette in my gang. Dolf van Niekerk. Pretoria: Protea Boekhuis ...

African Journals Online (AJOL)

instink en rede kan verder afgelees word uit die metaforiese lading in 'n titel soos Nag op 'n kaal plein (wat, terloops, herinner aan die titel van Bernlef se skitterende Nederlandse vertalings van die Sweedse Nobelprysdigter Tomas. Tranströmer, Het wilde plein). Van Niekerk se belangstelling in die klassiek—in die huidige ...

* * E rnst F uchs , Was ist Theologie1J. C. B. Mohr, Tübingen, 1953 ...

African Journals Online (AJOL)

Test

waarheidgetuienis en wysbegeerte is die denkbeweging van die waarheids- soeker. Die teologie dink, terwyl dit verhelder wat dit glo; die wysbegeerte dink, terwyl dit in begrippe verhelder wat dit begryp. Die wéreld waarmee die teologie sig besighou, is die mens wat deur God opgeroep word om mens te wrees soos die ...

Substitution of lucerne hay by ammoniated wheat straw in growth ...

African Journals Online (AJOL)

Lucerne hay (LH) was substituted by urea-ammoniated wheat straw (AWS) in four lamb-growth diets, all containing 60% roughage. ... Die ekonomiese voordeel van die verplasing van 'n hoë kwaliteit ruvoer, soos LH, met'n goedkoper bron (AKS), moet opgeweeg word teen die laer DMI en GDT, sowel as die nadelige effek ...

EUNUG IN DIE ANTIEKE NABYE OOSTE

African Journals Online (AJOL)

rang. In Assiries beteken die woord “hoof-eunug”. Soos reeds vermeld (by 2), vorm die eunug 'n belangrike deel van die Assiriese burokrasie. Dokumente dui aan ... rang in die Babiloniese weermag, en so 'n amptenaar het saam met die rabsag ..... baie laat, in die inter-testamentêre periode, gebruik is vir 'n gekastreerde.

Nuclear fuel cycle: international market, international constraints and international cooperation

International Nuclear Information System (INIS)

Imai, R.

1977-01-01

Some of the constraints on the nuclear fuel cycle are ones arising from economic and financial reasons, those caused by uranium resources and their distribution, those arising from technical reasons, issues of public acceptance, and those quite independent of normal industrial considerations, but caused by elements of international politics. The nuclear fuel cycle and the international market, matters of nuclear non-proliferation, and international cooperation are discussed

Readings from Asia: From Post-postwar to Postdisaster: Two Views of Japanese Society Since the 2000s

Directory of Open Access Journals (Sweden)

Hyojin Kim

2012-06-01

Full Text Available "Readings from Asia" highlights significant recent scholarship published in Chinese, Korean, Japanese, and Vietnamese, in order to bring it to the attention of a wider, international readership. This issue of Cross-Currents features a review essay by Hyojin Kim about a pair of recent books in Japanese that explore two vital aspects of the rapid changes that Japan has experienced in the third millennium: the Internet and nuclear power plants.

Local Governance and Corruption

Directory of Open Access Journals (Sweden)

Marius PROFIROIU

2006-06-01

Full Text Available This paper attempts to examine, from the Romanian perspective, the degree to which decentralization process and improvement of local governance contributes to the reduction of corruption in the short and medium term. Through the methodology that is used the paper is consistent with the international trend that endeavors to analyze the impact of corruption on economic and social processes at the local level. In addition, recent research on corruption issues has focused upon the measurement of the level of corruption level and on its impact on the growing rate of the GDP (Mauro [1995]1, Abed and Davoodi2, Krueger [1974]3, on the impact upon some of the national economical sectors (Tanzi [1998]4, Shang-Jin Wei [2001]5, or on the decentralization processes (Shah [2006]6.

Joint Services Electronics Program. Electronics Research at the University of Texas at Austin.

Science.gov (United States)

1986-09-30

White, Physics Kyoung II Kim , ECE John White, Aerospace Tae Sung Kim , ECE Murray Wolinsky, Physics Taiho Koh, ECE * L.A. Wu, Physics Tom Koonce...on Acutc.SpehadSignal Processing, Vol. 1, March 1984, San Diego, California, pp. - ’ -’.,"" 27. Kyoung 11 Kim and Edward J. Powers, "Digital Estimation...Craig Farley, ECE, M.S., May 1985, "The Migration and Activation of Impurities in Ion- Implanted Semiconductors." Dae Yong Kim , ECE, M.S., May 1985

Physics Proofs of Four Millennium-Problems(MP) via CATEGORY-SEMANTICS(C-S)/F=C Aristotle SQUARE-of-OPPOSITION(SoO) DEduction-LOGIC DichotomY

Science.gov (United States)

Clay, London; Siegel, Edward Carl-Ludwig

2011-03-01

Siegel-Baez Cognitive-Category-Semantics"(C-C-S) tabular list-format matrix truth-table analytics SoO jargonial-obfuscation elimination query WHAT? yields four "pure"-maths MP "Feet of Clay!!!" proofs: (1) Siegel [AMS Natl.Mtg.(02)-Abs.973-03-126: (CCNY;64)(94;Wiles)] Fermat's: Last-Thm. = Least-Action Ppl.; (2) P=/=NP TRIVIAL simple Euclid geometry/dimensions: NO computer anything"Feet of Clay!!!"; (3) Birch-Swinnerton-Dyer conjecture; (4) Riemann-hypotheses via COMBO.: Siegel[AMS Natl.Mtg.(02)-Abs.973-60-124] digits log-law inversion to ONLY BEQS with ONLY zero-digit BEC, AND Rayleigh[1870;graph-thy."short-CUT method"[Doyle-Snell, Random-Walks & Electric-Nets,MAA(81)]-"Anderson"[(58)] critical-strip C-localization!!! SoO DichotomY ("V") IdentitY: #s:(Euler v Bernoulli) = (Sets v Multisets) = Quantum-Statistics(FD v BE) = Power-Spectra(1/f(0) v 1/f(1)) = Conic-Sections(Ellipse v Hyperbola) = Extent(Locality v Globality);Siegel[(89)] (so MIScalled) "complexity" as UTTER-SIMPLICITY(!!!) v COMPLICATEDNESS MEASURE(S) definition.

Vroue, nasie en verwoording in Sharai Mukonoweshuro se Shona-romans

Directory of Open Access Journals (Sweden)

Maurice T. Vambe

2013-10-01

Full Text Available Die doel van hierdie artikel is om die fiktiewe voorstelling van vroue in twee van Sharai Mukonoweshuro se romans, naamlik Ndakagara Ndazviona en Akafuratidzwa Moyo, te verken. Tradisionele Shona verwagtinge van hoe ’n vrou moet optree, skryf die rolle voor wat van vroue verwag word om in die samelewing te speel. In ’n koloniale konteks soos die voormalige Rhodesië het kolonialisme wette in die gewoontereg bedink wat vroue verder gedegradeer het tot sosiale posisies soortgelyk aan dié van minderjariges. Hoewel die nasionalistiese stryd in wese bedoel was om vryheid te waarborg vir alle Swart mense, ongeag van geslag, het die manlike elites Swart vroue as hul minderwaardige ‘ander‘ gekonstrueer. In hierdie artikel word geargumenteer dat Sharai Mukonoweshuro se romans worstel met hierdie manlik-goedgekeurde stereotipes. Maar, soos getoon word, Mukonoweshuro se wyse van weerstand teen vroulike stereotipes is ambivalent; die skrywer skep jong vroue wat die patriargie aan die een kant uitdaag, en aan die ander kant, ou vroue wat die ondenkbare doen om hulle eie seuns te vergiftig.

Are Shaman Paintings Material Religion or Religious Art?

Directory of Open Access Journals (Sweden)

Jong-chun Park

2017-12-01

Full Text Available Laurel Kendall, Jongsung Yang, and Yul Soo Yoon. God Pictures in Korean Contexts: The Ownership and Meaning of Shaman Paintings. Honolulu: University of Hawai'i Press, 2015. God Pictures in Korean Contexts: The Ownership and Meaning of Shaman Paintings is a pioneering work, one that explores the proverbial “road not taken” by previous research on the subject. The authors situate “the lives of Korean shaman paintings [musindo] in a complex South Korean world; in shaman shrines, private collections, and museums." Incorporating their vivid experiences in the field, authors Laurel Kendall, anthropologist and curator at the American Museum of Natural History; Jongsung Yang, collector and director of the Museum of Shamanism in Seoul; and Yul Soo Yoon, art historian and director of the Gahoe Museum in Seoul, investigate not merely the religious meanings and functions of shaman paintings, but how these meanings and functions are accepted, appropriated, and even created, depending on the interests of various participants—shamans, painters, collectors of shaman paintings, and so on—who are relevant to these visual forms of expressive culture.

Decreased serum level of NGF in alcohol-dependent patients with declined executive function

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Bae H

2014-11-01

Full Text Available Hwallip Bae,1 Youngsun Ra,1 Changwoo Han,2 Dai-Jin Kim3 1Department of Psychiatry, Myongji Hospital, Goyang, 2Department of Psychiatry, Keyo Hospital, Uiwang, 3Department of Psychiatry, Seoul St Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea Abstract: The role of neurotrophic factors has been highlighted as a cause of decline in the cognitive function of alcohol-dependent patients. It is known that nerve-growth factor (NGF, one of the neurotrophins, is related to the growth and differentiation of nerve cells, as well as to a decline in cognitive function. The purpose of this study was to investigate the relationship between decreased NGF levels and cognitive decline in alcohol-dependent patients. The serum concentration of NGF was measured in 38 patients with chronic alcohol dependence, and several neuropsychological tests were also performed for cognitive function assessment. The results indicated a significant correlation between serum NGF level and the trail-making test part B, which evaluates executive function, but did not show a significant correlation with other cognitive function tests. An increased serum level of NGF was associated with a decreased completion time in the trail-making test B, and this finding indicates that a high serum level of NGF is related to greater executive function. This finding may imply a protective role of NGF in preventing neuron damage among patients with alcohol dependence. Larger controlled studies will be necessary in the future to investigate this issue further. Keywords: nerve-growth factor, alcohol dependence, executive function, trail-making test

Cationic PLGA/Eudragit RL nanoparticles for increasing retention time in synovial cavity after intra-articular injection in knee joint

Directory of Open Access Journals (Sweden)

Kim SR

2015-08-01

Full Text Available Sung Rae Kim,1 Myoung Jin Ho,2 Eugene Lee,3 Joon Woo Lee,3 Young Wook Choi,1 Myung Joo Kang21College of Pharmacy, Chung-Ang University, Dongjak-gu, Seoul, 2College of Pharmacy, Dankook University, Dongnam-gu, Cheonan, Chungnam, 3Department of Radiology, Seoul National University Bundang Hospital, Bundang-gu, Seongnam, Gyeonggi-do, South KoreaAbstract: Positively surface-charged poly(lactide-co-glycolide (PLGA/Eudragit RL nanoparticles (NPs were designed to increase retention time and sustain release profile in joints after intra-articular injection, by forming micrometer-sized electrostatic aggregates with hyaluronic acid, an endogenous anionic polysaccharide found in high amounts in synovial fluid. The cationic NPs consisting of PLGA, Eudragit RL, and polyvinyl alcohol were fabricated by solvent evaporation technique. The NPs were 170.1 nm in size, with a zeta potential of 21.3 mV in phosphate-buffered saline. Hyperspectral imaging (CytoViva® revealed the formation of the micrometer-sized filamentous aggregates upon admixing, due to electrostatic interaction between NPs and the polysaccharides. NPs loaded with a fluorescent probe (1,1'-dioctadecyl-3,3,3',3' tetramethylindotricarbocyanine iodide, DiR displayed a significantly improved retention time in the knee joint, with over 50% preservation of the fluorescent signal 28 days after injection. When DiR solution was injected intra-articularly, the fluorescence levels rapidly decreased to 30% of the initial concentration within 3 days in mice. From these findings, we suggest that PLGA-based cationic NPs could be a promising tool for prolonged delivery of therapeutic agents in joints selectively.Keywords: PLGA, Eudragit RL, hyaluronic acid, cationic nanoparticles, intra-articular injection, electrostatic interaction

Working Programme 2010. Knowledge Institute for Mobility Policy

International Nuclear Information System (INIS)

Jorritsma, P.; Derriks, H.; Francke, J.; Gordijn, H.; Groot, W.; Harms, L.; Van der Loop, H.; Peer, S.; Savelberg, F.; Wouters, P.

2009-12-01

The Dutch Knowledge Institute for Mobility Policy (KiM) provides analyses of mobility that influence the policy. As a separate institute within the Ministry of Transport, Public Works and Water management, the KiM conducts strategic outlooks and policy analyses. KiM establishes working programs annually. [nl

Tubular kidney injury molecule-1 in protein-overload nephropathy

NARCIS (Netherlands)

van Timmeren, Mirjan M.; Bakker, Stephan J. L.; Vaidya, Vishal S.; Bailly, Veronique; Schuurs, Theo A.; Damman, Jeffrey; Stegeman, Coen A.; Bonventre, Joseph V.; van Goor, Harry

Kim-1, a recently discovered membrane protein, is undetectable in normal kidneys but markedly induced in proximal tubules after ischemic and toxic injury. The function of Kim-1 is unclear, but it is implicated in damage/repair processes. The Kim-1 ectodomain is cleaved by metalloproteinases and

International Criminalization of International Terrorizm

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Alexander Grigoryevich Volevodz

2014-01-01

Full Text Available Analysis and studying of the terrorism in all its facets is a complex entangled problem with less clear legal regulation that it might seem at first glance, especially after its transformation from local phenomenon into a world threat. Hitherto terrorism and actions connected to it have been criminalized by the majority of states. There are in modern criminal law whole systems of rules on criminal liability for terrorism which differs considerably from country to country. Terrorism has been criminalized in numerous international regional and universal antiterrorist legal instruments. The author notes that differences in definitions that are enshrined in them hinders international cooperation in criminal matters with respect to terrorist cases. Difficulties reside in the necessity to meet the dual criminality requirement and in the political offense exception. These difficulties can only be overcome through elaboration of a universally recognized definition of the notion of international terrorism and making it legally binding via its inclusion into a universal convention. The issue of definition of international terrorism is an important part of an efficient mutual assistance among states in fight against this crime. In this article the author accounts of actual ways of tackling by the international community of the issue of criminalization of international terrorism and of factors influencing them.

Drug–drug interaction of microdose and regular-dose omeprazole with a CYP2C19 inhibitor and inducer

Directory of Open Access Journals (Sweden)

Park G

2017-03-01

Full Text Available Gab-jin Park,1 Soo Hyeon Bae,1 Wan-Su Park,1 Seunghoon Han,1 Min-Ho Park,2 Seok-Ho Shin,2 Young G Shin,2 Dong-Seok Yim1,2 1Department of Clinical Pharmacology and Therapeutics, Seoul St Mary’s Hospital, PIPET (Pharmacometrics Institute for Practical Education and Training, College of Medicine, Catholic University of Korea, Seoul, South Korea; 2College of Pharmacy, Chungnam National University, Daejeon, South Korea Purpose: A microdose drug–drug interaction (DDI study may be a valuable tool for anticipating drug interaction at therapeutic doses. This study aimed to compare the magnitude of DDIs at microdoses and regular doses to explore the applicability of a microdose DDI study. Patients and methods: Six healthy male volunteer subjects were enrolled into each DDI study of omeprazole (victim and known perpetrators: fluconazole (inhibitor and rifampin (inducer. For both studies, the microdose (100 µg, cold compound and the regular dose (20 mg of omeprazole were given at days 0 and 1, respectively. On days 2–9, the inhibitor or inducer was given daily, and the microdose and regular dose of omeprazole were repeated at days 8 and 9, respectively. Full omeprazole pharmacokinetic samplings were performed at days 0, 1, 8, and 9 of both studies for noncompartmental analysis. Results: The magnitude of the DDI, the geometric mean ratios (with perpetrator/omeprazole only of maximum concentration (Cmax and area under the curve to the last measurement (AUCt of the microdose and the regular dose were compared. The geometric mean ratios in the inhibition study were: 2.17 (micro and 2.68 (regular for Cmax, and 4.07 (micro, 4.33 (regular for AUCt. For the induction study, they were 0.26 (micro and 0.21 (regular for Cmax, and 0.16 (micro and 0.15 (regular for AUCt. There were no significant statistical differences in the magnitudes of DDIs between microdose and regular-dose conditions, regardless of induction or inhibition. Conclusion: Our results may be

Historik jiné moderny: Té horší

Czech Academy of Sciences Publication Activity Database

Hlavačka, Milan

2017-01-01

Roč. 30, 24. 6. (2017), s. 22 ISSN 0862-5921 Institutional support: RVO:67985963 Keywords : Bedřich Loewenstein * historian * modern civilisation OBOR OECD: History (history of science and technology to be 6.3, history of specific sciences to be under the respective headings)

Array based Discovery of Aptamer Pairs (Open Access Publisher’s Version)

Science.gov (United States)

2014-12-11

Array-based Discovery of Aptamer Pairs Minseon Cho,†,‡ Seung Soo Oh,‡ Jeff Nie,§ Ron Stewart,§ Monte J. Radeke,⊥ Michael Eisenstein ,†,‡ Peter J...ac504076k | Anal. Chem. 2015, 87, 821−828827 (24) Cho, M.; Oh, S. S.; Nie, J.; Stewart, R.; Eisenstein , M.; Chambers, J.; Marth, J. D.; Walker, F

"Ikka öeldakse : tõde ja õigus ..." / Siiri Ushakova

Index Scriptorium Estoniae

Ushakova, Siiri

2005-01-01

6. aug. esietendus Alatskivi Hirveaias lavastus "Kus mägi, seal mõis, kus küngas, seal kõrts, talud soo ja raba sees". Idee autor Ülo Must, stsenarist ja lavastaja Reet Kruup. Esitas Alatskivi näitetrupp. Näidend kajastab sündmust, mis leidis aset Alatskivi mõisas 1905. aasta 2. märtsil

ONDERHOUD MET EDWIN ARRISON1

African Journals Online (AJOL)

So ons het daardie week gehad, en in daardie week het daar 'n hele klompie goed gebeur waarvan ek heeltemal onbewus was. Byvoorbeeld, ek het skielik daardie week besef iemand soos Jeremiah. Wright kom na die konferensie toe. Ek weet nie of jy vir Jeremiah Wright ken nie, maar hy was Barack Obama se pastoor ...

Browse Title Index

African Journals Online (AJOL)

Items 401 - 450 of 473 ... Vol 6, No 1 (2003), The Effect of Animal and Plant Protein-Based Diets on the Crude Protein Requirement of Cockerel Starters, Abstract. RI Salami, SOO Oyewole, AA Odunsi, IO Ogunlade. Vol 4, No 2 (2001), The effect of calcium and phosphorus supplementation on the composition of milk and blood ...

Die verhouding tussen kerk en staat: Enkele modelle met verwysing ...

African Journals Online (AJOL)

ook ingaan op die vraag na die reg tot opstand teen die gesag van die staat soos dit in hierdie modelle beantwoord word. Ons wil eindig by die vraag na 'n teologiese model wat geskik is vir ons dag. 1. DIE TEOLOGIESE MODEL VAN DIE ROOMS-KATOLIEKE. KERK. Die Rooms-Katolieke Kerk se opvatting word bepaal ...

Kolme näoga Pädaste häärber / Jana Rand

Index Scriptorium Estoniae

Rand, Jana, 1963-

2008-01-01

Pädaste mõisa renoveeritud peahoonest. Mõisa ajaloost ja omanikest. Kommenteerib Pädaste mõisa omanik ja sisekujundaja Imre Sooäär, kelle kavandatud on ka hulk uuemat puitmööblit. Joonised aitas teha Kärt Kukkur. Restorani laes on šveitsi kunstniku Heinz Juleni loodud lühter. 12 värv. vaadet

die geni,rasie-ini'erva[, van dte suid-afrikaanse vleismerino 31)00

African Journals Online (AJOL)

met 'n afname in kuddegrootte is hierdie parameter beraam vir elke afsonderlike stratum van die teeltstruk- tuur soos diagrammaties voorgestel in Figure I en 2. Die belangrikheid hiervan is veral geled in die feit dat teeltvordering in die bedryf in 'n groot mate aangewys. f l 0. - 1 0. Int erva I. Velandering in die interval lll lare.

Operation and Maintenance Manual for Draw Off-Holdback (DOHB) Tension Machine

Science.gov (United States)

1982-12-01

Pickling and Treatment Appendix C -Nonferrous Pipe Pickling and Treatment (copper. copper-nickel, bronze) SZf CODE IDENT NO. REV ... .. f1 .h~n A 16603...Fiand3. Fr.nC.. G&I’mory. 0,..,., Holand . India. Ilan. Italy. Jeoon Womr,c0 New4 Zedaland. Nolitril. Peu SooM Africa. Seamn. Sweal", Switzerland. Turkey

Vrede in die boek van Esegiël

African Journals Online (AJOL)

14 Aug 2015 ... Die eerste en derde gedeeltes van die boek kan soos volg in verdere onderafdelings ingedeel word: • 1–24: Profesieë (van oordeel) teen Israel voor die val van Jerusalem. • 1–3: Roepingsvisioen. • 4–11: Tekens en gesigte wat oordeel oor Israel aankondig en veral teen Juda en Jerusalem gerig is.

Top 10 Estonian albums of 2004 / Igor Garshnek

Index Scriptorium Estoniae

Garšnek, Igor, 1958-

2004-01-01

Heliplaatidest: Arvo Pärt "Pro et contra", Various composers "Baltic Voices 2", Raimo Kangro "Displays", Toivo Tulev "Be Lost in the Call", Indrek Vau and Mati Mikalai "Estonian Trumpet Music", Erdmann/Sooäär "Dessert Time, Peer Gynt & Other Stories", Alo Mattiisen "50 parimat laulu", Riho Sibul "Must", Rein Rannap "Tantsib klaveril", Eesti Keeled "Kella tiksumist..."

PER 2009(4)

African Journals Online (AJOL)

PER Electronic Law Review - Potchefstoomse Elektroniese Regsblad

38 In Wes-Australië is die gekodifiseerde verweer van noodweer, soos vervat in die Criminal. Code, in 2008 op grond van ... 39 In Victoria word noodweer in die algemeen deur a 9AC en 9AE Crimes Act 1958 gereël, terwyl a 9AH spesifieke ...... uitg (Printing Things Potchefstroom 2005). Roth Briefing Paper No 3/07.

DIE SUID-AFRIKAANSE JEUG IN VOORTREKKERTYDPERK

African Journals Online (AJOL)

dien. Die planke en velie moes keer dat die assegaaie die mense tref. Voor die geveg het die vrouens en groter dogters koeels gegiet. Tydens die geveg het die seuns gehelp skiet terwyl die vrouens en dogters die gewere vir die mans gelaai het. Van die dogters soos Nellie. Botha (11 jaar oud) en haar sussie Fya (15 jaar.

Press Liaison Committees

African Journals Online (AJOL)

19 Jun 1971 ... Soos duidelik blyk uit advertensies vir ambulansposte is dit beslis nie op die oomblik die geval nie. Een munisipaliteit verlang 'n standerd 7-sertifikaat en bied dan slegs. R1 860 aan as aanvangsalaris indien die kandidaat tussen 20 en 24 jaar oud is. Daar sal seker diegene wees wat aansoek doen en wat ...

Kenmerkend van hierdie afdeling is die tema van ouderdom wat in ...

African Journals Online (AJOL)

8 Apr 2016 ... Kenmerkend van hierdie afdeling is die tema van ouderdom wat in menige van die stories voorkom. Hier is dit die onvermydelike aftakelingsproses van die liggaam (en verstand) wat 'n beduidende invloed op die skrywer het. In verhale soos “Wat 'n lieflike geraas”, “Die ou met die overall”, “Lofredes en ...