Book of short papers : International symposium on convective heat and mass transfer in sustainable energy Conv - 09. Volume 1

International Nuclear Information System (INIS)

2009-01-01

This book contains the short papers from the International Symposium on Convective heat and Mass Transfer in sustainable Energy ( Conv-09), organized on behalf of the International Centre for Heat and Mass Transfer, it was held on April 26- 1st May, In Hammamet, Tunisia. The objective of this conference is to bring together researchers in a forum to exchange innovative ideas, methods and results, and visions of the future related to the general theme of convective heat and mass transfer

Book of short papers : International symposium on convective heat and mass transfer in sustainable energy conv - 09. Volume 2

International Nuclear Information System (INIS)

2009-01-01

This book contains the short papers from the International Symposium on convective heat and Mass Transfer in sustainable Energy ( conv-09), organized on behalf of the International Centre for Heat and Mass Transfer, it was held on April 26- 1st May, In Hammamet, Tunisia. The objective of this conference is to bring together researchers in a forum to exchange innovative ideas, methods and results, and visions of the future related to the general theme of convective heat and mass transfer

Cross-correlations between RMB exchange rate and international commodity markets

Science.gov (United States)

Lu, Xinsheng; Li, Jianfeng; Zhou, Ying; Qian, Yubo

2017-11-01

This paper employs multifractal detrended analysis (MF-DFA) and multifractal detrended cross-correlation analysis (MF-DCCA) to study cross-correlation behaviors between China's RMB exchange rate market and four international commodity markets, using a comprehensive set of data covering the period from 22 July 2005 to 15 March 2016. Our empirical results from MF-DFA indicate that the RMB exchange rate is the most inefficient among the 4 selected markets. The results from quantitative analysis have testified the existence of cross-correlations and the result from MF-DCCA have further confirmed a strong multifractal behavior between RMB exchange rate and international commodity markets. We also demonstrate that the recent financial crisis has significant impact on the cross-correlated behavior. Through the rolling window analysis, we find that the RMB exchange rates and international commodity prices are anti-persistent cross-correlated. The main sources of multifractality in the cross-correlations are long-range correlations between RMB exchange rate and the aggregate commodity, energy and metals index.

77 FR 24752 - Self-Regulatory Organizations; EDGA Exchange, Inc.; EDGX Exchange, Inc.; International Securities...

Science.gov (United States)

2012-04-25

... Securities Holdings, Inc. (``ISE Holdings'') to a newly formed Swiss corporation, Eurex Global Derivatives AG... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-66834; File Nos. SR-EDGA-2012-08; SR-EDGX-2012....; International Securities Exchange, LLC; Order Granting Approval of Proposed Rule Change Relating to a Corporate...

Educational Exchanges in Public Diplomacy: Russian and International Experience

Directory of Open Access Journals (Sweden)

Alexey Dolinkiy

2014-01-01

Full Text Available Education exchanges are a key element of public diplomacy for most countries that considered effective in that domain of foreign policy activities. Education exchanges are attributed an important role in the post-war peace settlement between Germany and France and in determining the outcome of the Cold war. Relevant aspects of public diplomacy remain key elements of foreign policy instruments of the US, Germany and many other countries. Russia has been increasingly active in public diplomacy in the past decade and the role of education exchanges has been increasing which is also demonstrated by a growing number of expert publications on the subject. However the strategy, the quality of organization and the use of modern technologies remain at a relatively low level which leads to an inefficient use of resources. Priority issues that can be a core of Russia's public diplomacy (and foreign policy in general. Moreover, systemic work would be required to evaluate efficiency of current and complete projects which would allow determine effectiveness of programs and appropriateness of resources used. Education exchanges need to be targeted at both bringing international students to Russia and assisting Russian students to study internationally and professors to teach abroad. Finally, international best practices show that there is a need to maintain connections with international exchanges alumni and assist them to maintain connections with each other including with the use of modern technologies.

Foreign Exchange Risk in International Transactions

Directory of Open Access Journals (Sweden)

Florentina-Olivia Balu

2007-03-01

Full Text Available Every international business is affected by the ever-changing value of the currencies implied in contracts. While many of us consider this unpredictability a nuisance, the volatility of currencies around the world can mean the difference between success and failure for many exporters/importers. Exchange rates between one currency and another can change dramatically in a short period of time, leaving the unprepared business exposed to potentially crippling losses. The efficient management of this risk is essential for the survival of a company and any business that is exposed to such a risk should ensure that it is fully prepared to manage it. Old standbys and recent breakthroughs in the area of financial risk management can remove much of the risk from currency rate movements. The range of such products is huge, with increasingly sophisticated techniques constantly being added. Among the most modern methods for managing exchange risk there are four major classes of derivative products like: forwards, futures, options, and swaps. Beyond the four main types of risk management instruments, there are a number of other products including "swaptions" (options on swaps; avenging options; yield curve swaps; futures on spreads; and options on portfolios. Sophisticated mathematical tools and high-speed computers are needed to calculate the price of these instruments and to determine their overall effect on the company. In this article we will focus on forward and futures contracts for managing foreign exchange risk. A forward is a contract to buy or sell currency at an agreed upon exchange rate at a specific date in the future. Futures are similar to forwards except that they're traded on exchanges which specify settlement dates. Also we make some recommendations related to the foreign exchange risk-management practices that are useful for companies involved in international trade and for financial institutions interested in providing hedging products to

SAIDE: A Semi-Automated Interface for Hydrogen/Deuterium Exchange Mass Spectrometry.

Science.gov (United States)

Villar, Maria T; Miller, Danny E; Fenton, Aron W; Artigues, Antonio

2010-01-01

Deuterium/hydrogen exchange in combination with mass spectrometry (DH MS) is a sensitive technique for detection of changes in protein conformation and dynamics. Since temperature, pH and timing control are the key elements for reliable and efficient measurement of hydrogen/deuterium content in proteins and peptides, we have developed a small, semiautomatic interface for deuterium exchange that interfaces the HPLC pumps with a mass spectrometer. This interface is relatively inexpensive to build, and provides efficient temperature and timing control in all stages of enzyme digestion, HPLC separation and mass analysis of the resulting peptides. We have tested this system with a series of standard tryptic peptides reconstituted in a solvent containing increasing concentration of deuterium. Our results demonstrate the use of this interface results in minimal loss of deuterium due to back exchange during HPLC desalting and separation. For peptides reconstituted in a buffer containing 100% deuterium, and assuming that all amide linkages have exchanged hydrogen with deuterium, the maximum loss of deuterium content is only 17% of the label, indicating the loss of only one deuterium molecule per peptide.

Intelligent transportation system (ITS) international research exchange.

Science.gov (United States)

2014-01-01

ITS applications address surface transportation challenges in safety, mobility, and : sustainability that are similar in cause and impact worldwide. International ITS : exchange allows cooperating nations to benefit from each others pre-competitiv...

Mass transfer in liquid phase catalytic exchange column of trickle bed type

International Nuclear Information System (INIS)

Yamanishi, Toshihiko; Iwai, Yasunori; Okuno, Kenji

1995-09-01

The mechanism of mass transfer in a liquid phase catalytic exchange column was discussed for a trickle bed type. A new model has been proposed on the basis of this mass transfer mechanism; and several problems for the previous reported models were pointed out in the derivation of the model. An overall rate equation was first derived from the vapor-hydrogen exchange in the model. The mass transfer for the vapor-hydrogen exchange was decomposed to the following three steps: the mass transfer in a gas boundary layer on a catalyst particle; the mass transfer within the pores in the catalyst; and the chemical reaction on the surface of the catalyst. The water-vapor scrubbing process was considered as a series of the mass transfers in gas and liquid boundary layers on the wetted surfaces of the catalyst and packings or wall of the column. Significant subjects to be studied were proposed from the viewpoint of the validity of the model and the optimization of the column. (author)

Time evolution of the mass exchange in grazing heavy-ion collisions

International Nuclear Information System (INIS)

Bastrukov, S.I.; Deak, F.; Kiss, A.; Seres, Z.

1989-10-01

On the basis of a macroscopical approach to the description of two interpenetrating quantum objects, the equations of two-fluid hydrodynamics for the cohesion stage of deeply inelastic heavy-ion collisions are formulated. The elasticity of the ions is analyzed in peripheral mass exchange reactions at intermediate energies. The system of closed equations of Newtonian mechanics, which simultaneously describes the motion of the ions along classical trajectories as well as the mass time evolution during the interaction period are derived and solved. The role of mass exchange in the friction force is discussed. (author) 22 refs.; 2 figs

THE IMPLICATIONS OF VARYING EXCHANGE RATES FOR THE INTERNATIONAL TRADE

Directory of Open Access Journals (Sweden)

Sandu Carmen

2011-07-01

Full Text Available The benefit of international trade is a more efficient employment of the productive forces of the world. (John Stuart Mill The exchange rate is a primary factor that influences economy. This instrument is used by some countries in order to improve the lack of balance caused as a result of the financial crisis felt in many countries considered by then infallible. The negative effects of the financial crisis can also be found in the decreased volume of commodities involved in international trade exchanges, as a consequence of modified prices and decreased offer. The globalizing trend leads to a constant expansion of exchanges between countries and to the consolidation of international cooperation. Except that economic interdependence generates an increased risk under the influence of economic, financial, monetary or political factors. The currency risk can generate either a gain or loss during foreign trade operations. The long period of RON depreciation made possible the entry of Romanian products on the international markets due to their prices. Sheltered by the gain generated by the evolution of the exchange rate, most of the exporters were not concerned by the increase of product competitiveness or by avoiding the currency risk. The fact that, for many years, the evolution of the exchange rate generated substantial losses for the exporters shows that risk coverage in Romania is, in most cases, a purely theoretical concept.

Exchange Rate and International Trade: Case From Indonesian Manufacturing Sector

Directory of Open Access Journals (Sweden)

Anung Yoga Anindhita

2017-07-01

Full Text Available Exchange rate fluctuation in Floating Exchange Rate Regime is considered to Exchange rate fluctuation in Floating Exchange Rate Regime is considered to have impacts on the international trade through its adjustment to the price and its volatility to the trade risk. This paper is aimed at estimating those impacts on the international trade of manufacturing sector in Indonesia for period 2007 to 2014. To conduct estimation, it uses multiple regression analysis on two models: First, the import of raw-and-auxiliary materials; Second, the export of manufacturing sector. The results show that the exchange rate impacts both work significantly on the import of raw-and-auxiliary materials. The finding implies that, through the import of raw-and-auxiliary materials, manufacturing sector is very susceptible to the shock caused by exchange rate changes. Meanwhile, the export of manufacturing sector is not able to take advantage of the depreciation of the exchange rate due to the lack of competitiveness.DOI: 10.15408/sjie.v6i2.5210

75 FR 32977 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2010-06-10

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed... Permit Opening Transactions by Market Makers To Accommodate Closing Transactions of Other Market... International Securities Exchange, LLC (``Exchange'' or ``ISE'') filed with the Securities and Exchange...

Transport and mass exchange processes in sand and gravel aquifers (v.1)

International Nuclear Information System (INIS)

Moltyaner, G.

1990-01-01

The objectives of this conference were to exchange information on promising field measurement techniques used for the characterization of spatial variability of geologic formations and on new methods used for quantifying the effect of spatial variability on groundwater flow and transport of materials; to discuss novel developments in the theory of transport processes and simulation methods; and to present views and opinions on future initiatives and directions in the design of large-scale field tracer experiments and the development of conceptual and mathematical models of transport and mass exchange processes. The 46 papers presented in these proceedings are divided into six sections: field studies of transport processes; groundwater tracers and novel field measurement techniques; promising methods and field measurement techniques for quantifying the effect of geological heterogeneities on groundwater flow and transport; novel developments in the theory of transport processes; numerical modelling of transport and mass exchange processes; and field and modelling studies of mass exchange processes. (L.L.)

77 FR 34436 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Science.gov (United States)

2012-06-11

... Organizations; International Securities Exchange, LLC; Notice of Filing of Proposed Rule Change To Temporarily... International Securities Exchange, LLC (the ``Exchange'' or the ``ISE'') filed with the Securities and Exchange... Clearing and Outsourcing Solutions, Inc. (``Apex Clearing'') as an ISE member organization, subject to Apex...

Social Representation of Intercultural Exchange in an International University

Science.gov (United States)

Kudo, Kazuhiro

2016-01-01

This paper provides an interpretive investigation into the social representation of intercultural exchange at one of the newly established international universities in Japan. The author conducted quasi-structured interviews with 5 staff members and 22 students to gain insight into their perceptions of intercultural exchange and interactions. The…

Are international fund flows related to exchange rate dynamics?

NARCIS (Netherlands)

Li, Suxiao; de Haan, Jakob; Scholtens, Bert

2018-01-01

Employing monthly data for 53 countries between 1996 and 2015, we investigate the relationship between international fund flows and exchange rate dynamics. We find strong co-movement between funds flows (as measured with the EPFR Global data base) and bilateral real exchange rates vis-à-vis the USD.

Student experiences with an international public health exchange project.

Science.gov (United States)

Critchley, Kim A; Richardson, Eileen; Aarts, Clara; Campbell, Barbara; Hemmingway, Ann; Koskinen, Liisa; Mitchell, Maureen P; Nordstrom, Pam

2009-01-01

With growing interconnectivity of healthcare systems worldwide and increased immigration, inappropriate cultural and role assumptions are often seen when cultures clash within a country or when there is practice across country boundaries in times of disaster and during international travel. To increase students' multicultural awareness and work experiences abroad, the authors describe a 7-school, 5-country international student exchange project. The authors also share the students' evaluations of their experiences as they are challenged to erase boundaries and embrace nursing across countries. Participating faculty describe the process, challenges, and keys to success found in creating and living this international project. Students involved in the exchange process evaluate the learning opportunities and challenges and the joy of coming together as newfound colleagues and friends.

76 FR 51075 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Granting Approval to...

Science.gov (United States)

2011-08-17

... Organizations; International Securities Exchange, LLC; Order Granting Approval to a Proposed Rule Change Relating to Appointments to Competitive Market Makers August 11, 2011. I. Introduction On June 10, 2011, the International Securities Exchange, LLC (the ``Exchange'' or the ``ISE'') filed with the Securities...

The thermodynamics of heat- and mass exchange in chemical engineering. Vol. 1. 2. rev. ed.

International Nuclear Information System (INIS)

Matz, G.

1979-01-01

The second and completely revised edition of the approved textbook 'The thermodynamics of heat- and mass exchange in chemical engineering' is devoted to students of technical and natural science disciplines as well as to practicians and scientists, which are confronted with thermodynamical problems of chemical engineering. Starting from the different phases and properties of matter, the first and the second law of thermodynamics are discussed together with many applications. After an introduction of the equilibrium state, the general principle of similarity for heat- and mass exchange is discussed, considering in particular the heat- and mass exchange in the counter flow between two phases. In a final chapter, the heat- and mass exchange between the vapor- and liquid phase is discussed, with special emphasis on problems as evaporation and drying. (orig./HK) [de

Empirical Correction for Differences in Chemical Exchange Rates in Hydrogen Exchange-Mass Spectrometry Measurements.

Science.gov (United States)

Toth, Ronald T; Mills, Brittney J; Joshi, Sangeeta B; Esfandiary, Reza; Bishop, Steven M; Middaugh, C Russell; Volkin, David B; Weis, David D

2017-09-05

A barrier to the use of hydrogen exchange-mass spectrometry (HX-MS) in many contexts, especially analytical characterization of various protein therapeutic candidates, is that differences in temperature, pH, ionic strength, buffering agent, or other additives can alter chemical exchange rates, making HX data gathered under differing solution conditions difficult to compare. Here, we present data demonstrating that HX chemical exchange rates can be substantially altered not only by the well-established variables of temperature and pH but also by additives including arginine, guanidine, methionine, and thiocyanate. To compensate for these additive effects, we have developed an empirical method to correct the hydrogen-exchange data for these differences. First, differences in chemical exchange rates are measured by use of an unstructured reporter peptide, YPI. An empirical chemical exchange correction factor, determined by use of the HX data from the reporter peptide, is then applied to the HX measurements obtained from a protein of interest under different solution conditions. We demonstrate that the correction is experimentally sound through simulation and in a proof-of-concept experiment using unstructured peptides under slow-exchange conditions (pD 4.5 at ambient temperature). To illustrate its utility, we applied the correction to HX-MS excipient screening data collected for a pharmaceutically relevant IgG4 mAb being characterized to determine the effects of different formulations on backbone dynamics.

75 FR 66410 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2010-10-28

...-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to the Sales Value Fee October 22, 2010. Pursuant to Section 19(b... hereby given that, on October 14, 2010, the International Securities Exchange, LLC (the ``Exchange'' or...

76 FR 64980 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed...

Science.gov (United States)

2011-10-19

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-65548; File No. SR-ISE-2011-39] Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed Rule Change Relating to Complex Orders October 13, 2011. I. Introduction On July 1, 2011, the International Securities Exchange...

Taxpayers' confidentiality and privacy rights in the international exchange of tax information

Directory of Open Access Journals (Sweden)

Anđelković Mileva

2014-01-01

Full Text Available The exchange of tax information is a distinctive feature of international tax cooperation processes. The trend of intensive communication between the national tax administrations has been a political priority in economically developed countries. This area of international tax law has been subject to significant changes in the past few years. Countries are prompted to pursue the automatic exchange of tax information by entering into multilateral treaties on the exchange of tax information rather than engage in international exchange of tax information upon request by entering into bilateral agreements. These processes are promptly expedited owing to the incredible development of information and communication technologies. These developments are basically aimed at preventing different forms of international tax fraud which generate significant financial losses in the circumstances of current economic crisis. Such efforts may be justifiable regarding the interests of the countries of residence; but, what about the legal status of ordinary taxpayers who are now subject to a comprehensive and far-reaching control? The new concept may be appropriate for tracking tax fraud or embezzlement but what are its implications for law-abiding taxpayers? The national legislatures are obliged to provide for the protection of confidentiality of exchanged tax information but many states have not fully recognized the importance of providing adequate legal protection of sensitive personal and financial data. There are only a few countries whose legislations explicitly prescribe the taxpayers' right to be informed, the right to consult tax administration and the right to seek tax administration intervention as a form of legal protection in international exchange of tax information. The Serbian tax legislation does not envisage the obligation of tax authorities to notify the taxpayers about the request submitted by foreign tax authorities to provide some tax

76 FR 47627 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2011-08-05

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to Two Market Data Feeds August 1, 2011. Pursuant to Section 19(b)(1) of the... on August 1, 2011, the International Securities Exchange, LLC (the ``Exchange'' or the ``ISE'') filed...

77 FR 37722 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2012-06-22

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Eliminate the Rules and Fees Related to the Second Market June 18, 2012. Pursuant to...\\ notice is hereby given that on June 6, 2012, the International Securities Exchange, LLC (the ``Exchange...

78 FR 17988 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2013-03-25

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Regarding Market Maker Quoting Requirements March 19, 2013. Pursuant to Section 19(b)(1) of... given that on March 5, 2013, the International Securities Exchange, LLC (the ``Exchange'' or the ``ISE...

76 FR 32382 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2011-06-06

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to Second Market Fees May 27, 2011. Pursuant to Section 19(b)(1) of the Securities..., 2011, the International Securities Exchange, LLC (the ``Exchange'' or the ``ISE'') filed with the...

76 FR 56832 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2011-09-14

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to a New Market Data Feed September 8, 2011. Pursuant to Section 19(b)(1) of the... on August 31, 2011, the International Securities Exchange, LLC (the ``Exchange'' or the ``ISE...

76 FR 37863 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Science.gov (United States)

2011-06-28

... Organizations; International Securities Exchange, LLC; Notice of Filing of Proposed Rule Change Relating to Appointments to Competitive Market Makers June 22, 2011. Pursuant to Section 19(b)(1) of the Securities... that on June 10, 2011, the International Securities Exchange, LLC (the ``Exchange'' or the ``ISE...

Incentives and Information Exchange in International Taxation

NARCIS (Netherlands)

Keen, M.; Ligthart, J.E.

2004-01-01

The exchange of taxpayer-specific information between national tax authorities has recently emerged as a key and controversial topic in international tax policy discussions, most notably with the OECD s harmful tax practices project and the EU s savings tax initiative.This paper analyses the effects

78 FR 24271 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2013-04-24

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend the Market Maker Plus Rebate Program April 18, 2013. Pursuant to Section 19(b)(1... hereby given that on April 10, 2013, the International Securities Exchange, LLC (the ``Exchange'' or the...

78 FR 45580 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2013-07-29

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change to Amend Certain Market Maker Fees July 23, 2013. Pursuant to Section 19(b)(1) of the... hereby given that on July 11, 2013, the International Securities Exchange, LLC (the ``Exchange'' or the...

The international educational exchanges: history and modern value

Directory of Open Access Journals (Sweden)

L S Astafeva

2009-09-01

Full Text Available In article the history, a current state and prospects of development of the international educational exchanges is considered. Influence world processes of globalisation and internationalisation on educational processes of multinational high schools is shown.

International finance, Lévy distributions, and the econophysics of exchange rates

Science.gov (United States)

Da Silva, Sergio; Matsushita, Raul; Gleria, Iram; Figueiredo, Annibal; Rathie, Pushpa

2005-06-01

This paper surveys the developments in the field of international finance, in particular the research of economists on foreign exchange rates. That might be of interest to physicists working on the econophysics of exchange rates. We show how the econophysics agenda might follow naturally from the economists' research. We also present our own work on the econophysics of exchange rates.

75 FR 7299 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving Proposed...

Science.gov (United States)

2010-02-18

... to the U.S. Exchange Holdings, Inc. Corporate Documents and International Securities Exchange Trust... change relating to the U.S. Exchange Holdings, Inc. (``U.S. Exchange Holdings'') Corporate Documents (as... Holdings purchased an ownership interest in Direct Edge by contributing cash and the marketplace then...

Hydraulic Validation of the LHC Cold Mass Heat Exchanger Tube

CERN Document Server

Provenaz, P

1998-01-01

The knowledge of the helium mass flow vs. the fraction of the tube wetted by the liquid helium II in the heat exchanger is a crucial input parameter for the heat exchange since the heat flux is direct ly proportional to the wetted surface. In the range of liquid and gas velocities inside the heat exchanger, the liquid flow behaves like in an open channel. Looking at the flow equations for such a s ituation, the velocity depends on the fluid properties only by the friction factor which is a function of the Reynolds number. Thus it was decided to build an experiment with water in order to check t he open channel equations in the heat exchanger geometry. This paper shows the results for water and gives the extrapolation for helium.

Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry (HDX-MS)

DEFF Research Database (Denmark)

Esmail Nazari, Zeinab; van de Weert, Marco; Bou-Assaf, George

2016-01-01

Hydrogen Deuterium Exchange coupled to Mass Spectrometry (HDX-MS) has become an established method for analysis of protein higher-order structure. Here, we use HDX-MS methodology based on manual Solid-Phase Extraction (SPE) to allow fast and simplified conformational analysis of proteins under...... pharmaceutically relevant formulation conditions. Of significant practical utility, the methodology allows global HDX-MS analyses to be performed without refrigeration or external cooling of the setup. In Mode 1, we used DMSO-containing solvents for SPE, allowing the HDX-MS analysis to be performed at acceptable...... in formulation, using an internal HDX reference peptide (P7I) to control for any sample-to-sample variations in back exchange. Advantages of the methodology include low sample use, optimized excipient removal using multiple solvents, and fast data acquisition. Our results indicate that the SPE-HDX-MS system can...

76 FR 64417 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2011-10-18

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to Competitive Market Maker Trading Rights October 12, 2011. Pursuant to Section...\\ notice is hereby given that on October 3, 2011, the International Securities Exchange, LLC (the...

75 FR 2915 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed...

Science.gov (United States)

2010-01-19

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-61317; File No. SR-ISE-2009-103] Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed Rule Change Relating to Market Data Fees January 8, 2010. I. Introduction On November 25, 2009, the International...

77 FR 4852 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed...

Science.gov (United States)

2012-01-31

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-66234; File No. SR-ISE-2011-82] Self-Regulatory Organizations; International Securities Exchange, LLC; Order Approving a Proposed Rule Change Relating to Legging Orders January 25, 2012. I. Introduction On November 29, 2011, the International Securities...

77 FR 1757 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2012-01-11

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to a Market Maker Incentive Plan for Foreign Currency Options January 5, 2012...,\\2\\ notice is hereby given that on December 28, 2011, the International Securities Exchange, LLC (the...

75 FR 42812 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2010-07-22

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to a Market Maker Incentive Plan for Foreign Currency Options July 15, 2010..., \\2\\ notice is hereby given that on June 30, 2010, International Securities Exchange, LLC (``ISE'' or...

77 FR 31680 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2012-05-29

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change To Amend the Qualification Standards for Market Makers To Receive a Rebate May 22, 2012...-4 thereunder,\\2\\ notice is hereby given that on May 15, 2012, the International Securities Exchange...

International exchange of radiological information in the event of a nuclear accident - future perspectives

International Nuclear Information System (INIS)

De-Cort, M.; De-Vries, G.; Breitenbach, L.; Leeb, H.; Weiss, W.

1996-01-01

Immediately after the Chernobyl accident most European countries established or enhanced their national radioactivity monitoring and information systems. The large transboundary effect of the radioactive release also triggered the need for bilateral and international agreements on the exchange of radiological information in case of a nuclear accident. Based on the experiences gained from existing bi- and multilateral data exchange the Commission of the European Communities has made provision for and is developing technical systems to exchange information of common interest. Firstly the existing national systems and systems based on bilateral agreements are summarized. The objectives and technical realizations of the EC international information exchange systems ECURIE and EURDEP, are described. The experiences gained over the past few years and the concepts for the future, in which central and eastern European countries will be included, are discussed. The benefits that would result from improving the international exchange of radiological information in the event of a future nuclear accident are further being described

A Fraught Exchange? U.S. Media on Chinese International Undergraduates and the American University

Science.gov (United States)

Abelmann, Nancy; Kang, Jiyeon

2014-01-01

In this article, we analyze the U.S. media discourse on Chinese international undergraduate students, the largest international student group since 2009. The discourse describes a market "exchange", but reveals a struggle between: on the one hand, "a fair exchange"--between excellent Chinese students and world-class American…

International exchange training in genetic counseling: an exploration of the value in exchange experiences.

Science.gov (United States)

Alexander, Chelsea K A; Veach, Patricia McCarthy; Lian, Fengqin; LeRoy, Bonnie S

2013-12-01

International exchange training in genetic counseling is increasing, but research examining these experiences is lacking. In this study 309 genetic counseling students and genetic counselors completed an anonymous survey investigating six major research questions: (1) How prevalent are international genetic counseling experiences? (2) What types are pursued and why? (3) What supports and barriers exist? 3) What are the demographic characteristics of individuals accruing international experience? (5) Does international experience promote professional development? and (6) Do genetic counseling students and professionals perceive international experiences as beneficial? Most respondents were Caucasian females born in one of 25 countries. The most prevalent experiences involved either clinical observation or clinical training. Common motivations for pursuing international experience were personal growth, exposure to a different healthcare system, and travel opportunities. Outcomes included professionally-relevant experience and personal growth. Barriers included finances, limited availability of opportunities, and for those without international experience, family responsibilities. Additional findings, practice and training implications, and research recommendations are provided.

The American Nuclear Society's international student exchange program

International Nuclear Information System (INIS)

Bornstein, I.

1988-01-01

The American Nuclear Society's (ANS's) International Student Exchange Program sponsors bilateral exchanges of students form graduate schools in American universities with students from graduate schools in France, the Federal Republic of Germany (FRG), and Japan. The program, now in its 12th year, was initiated in response to an inquiry to Argonne National Laboratory (ANL) from the director of the Centre d'Etudes Nucleaires de Saclay proposing to send French nuclear engineering students to the United States for summer jobs. The laboratory was asked to accept two students to work on some nuclear technology activity and ANS was invited to send American students to France on an exchange basis. To date, 200 students have taken part in the program. It has been a maturing and enriching experience for them, and many strong and enduring friendships have been fostered among the participants, many of whom will become future leaders in their countries

Intracellular water exchange for measuring the dry mass, water mass and changes in chemical composition of living cells.

Directory of Open Access Journals (Sweden)

Francisco Feijó Delgado

Full Text Available We present a method for direct non-optical quantification of dry mass, dry density and water mass of single living cells in suspension. Dry mass and dry density are obtained simultaneously by measuring a cell's buoyant mass sequentially in an H2O-based fluid and a D2O-based fluid. Rapid exchange of intracellular H2O for D2O renders the cell's water content neutrally buoyant in both measurements, and thus the paired measurements yield the mass and density of the cell's dry material alone. Utilizing this same property of rapid water exchange, we also demonstrate the quantification of intracellular water mass. In a population of E. coli, we paired these measurements to estimate the percent dry weight by mass and volume. We then focused on cellular dry density - the average density of all cellular biomolecules, weighted by their relative abundances. Given that densities vary across biomolecule types (RNA, DNA, protein, we investigated whether we could detect changes in biomolecular composition in bacteria, fungi, and mammalian cells. In E. coli, and S. cerevisiae, dry density increases from stationary to exponential phase, consistent with previously known increases in the RNA/protein ratio from up-regulated ribosome production. For mammalian cells, changes in growth conditions cause substantial shifts in dry density, suggesting concurrent changes in the protein, nucleic acid and lipid content of the cell.

Exchange rate pass-through and the role of international distribution channels

OpenAIRE

Desiraju, Ramarao; Shrikhande, Milind

1996-01-01

Manufacturers selling in foreign markets often do not completely pass on the effects of fluctuations in exchange rates to the prices of their products. Our paper addresses this puzzle and studies the effects of the international distribution channel on exchange rate pass-through. We develop an exchange rate pass-through model that takes into account the role of an intermediary between a domestic manufacturer and its consumers in a foreign market. We find that the magnitude of the pass-through...

76 FR 6128 - Energy Exchange International, LLC; Supplemental Notice That Initial Market-Based Rate Filing...

Science.gov (United States)

2011-02-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. ER11-2730-000] Energy Exchange International, LLC; Supplemental Notice That Initial Market-Based Rate Filing Includes Request for... proceeding Energy Exchange International, LLC's application for market-based rate authority, with an...

Mass-independent isotope effects in chemical exchange reaction

International Nuclear Information System (INIS)

Nishizawa, Kazushige

2000-01-01

Isotope effects of some elements in chemical exchange reaction were investigated by use of liquid-liquid extraction, liquid membrane or chromatographic separation. Cyclic polyether was used for every method. All polyethers used in a series of the studies were made clear that they distinguished the isotopes not only by their nuclear masses but also by their nuclear sizes and shapes. Chromium isotopes, for example, were recognized to have enrichment factors being proportional to δ 2 > which is a parameter to show field shift or the nuclear size and shape of the isotope. It follows that the chromium isotopes are separated not by their masses but by their field shift effects. Nuclear spin also played a great role to separate odd mass number isotopes from even mass number isotopes in even atomic number elements. Contribution of the nuclear spin (I=3/2) of 53 Cr to total enrichment factor, ε 53/52 = -0.00028, for 53 Cr to 52 Cr was observed to be, ε spin = -0.0025. (author)

Segmentation across International Equity, Bond, and Foreign Exchange Markets

OpenAIRE

Cathy Ning; Stephen Sapp

2009-01-01

In this paper, we examine the integration of international financial markets. The integration of financial markets across countries and across asset classes is assumed to hold in most empirical studies, but has only been tested for certain countries and certain asset classes. We test for the integration of international equity, bond and foreign exchange markets. Our results indicate that the three classes of assets are segmented. Investigating potential explanations for this segmentation, we ...

Non-conservative mass exchange and origin of X-ray close binaries

International Nuclear Information System (INIS)

Sugimoto, D.; Miyaji, S.

1980-01-01

There are two distinct types of XCBS. The Type I XCBS consists of an X-ray star and an early type star more massive than about 12 solar masses. On the contrary, the Type II XCBS consists of an X-ray star and a star less massive than about 2 solar masses. The aim of the present paper lies in interpreting the origin of these types of XCBS on the bases of the conditions for the formation of a neutron star and of mass exchange in close binary systems. (Auth.)

The mass balance of a Proton Exchange Membrane Fuel Cell (PEMFC)

International Nuclear Information System (INIS)

Miloud, S.; Kamaruzzaman Sopian; Wan Ramli Wan Daud

2006-01-01

A Proton Exchange Membrane Fuel Cell (PEMFC), operating at low temperature uses a simple chemical process to combine hydrogen and oxygen into water, producing electric current and heat during the electrochemical reaction. This work concern on the theoretical consideration of the mass balance has been evaluated to predict the mass flow rate of the both gases (hydrogen/oxygen), the water mass balance, and the heat transfer in order to design a single cell PEMFC stack with a better flow field distributor on the performance of Polymer Electrolyte membrane fuel cells

Evidence of mass exchange between inside and outside of sonoluminescing bubble in aqueous solution of terbium chloride

Energy Technology Data Exchange (ETDEWEB)

Liang, Jinfu, E-mail: liang.shi2007@163.com [School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550001 (China); Chen, Weizhong, E-mail: wzchen@nju.edu.cn [The Key Laboratory of Modern Acoustics, Ministry of Education, Institution of Acoustics, Nanjing University, Nanjing 210093 (China); Wang, Xun; Yang, Jing; Chen, Zhan [The Key Laboratory of Modern Acoustics, Ministry of Education, Institution of Acoustics, Nanjing University, Nanjing 210093 (China)

2016-12-16

Highlights: • Time-resolved spectra of SBSL were obtained for Tb{sup 3+} ions emission lines. • Mass exchange between inside and outside of SL bubble was probed via Tb{sup 3+} ions lines. • The argon rectification hypothesis was tested by time-resolved spectra of SBSL. • The rate of mass exchange inside an SBSL bubble increases with increasing sound pressure. - Abstract: Spectra of single-bubble sonoluminescence (SBSL) were obtained for Tb{sup 3+} ions emission lines from bubbles in an aqueous solution of terbium chloride (TbCl{sub 3}). The spectra provide experimental evidence to prove that an air bubble driven by strong ultrasound will not eventually become a rectified pure argon bubble, which is not as predicted by the argon rectification hypothesis. The time-resolved spectra of SBSL show a mass exchange of material such as Tb{sup 3+} ions between the inside and outside of the bubble. With increasing sound pressure, the rate of mass exchange and the SBSL intensity increases.

Dynamics of internal waves on the Southeast Florida shelf: Implications for cross-shelf exchange and turbulent mixing on a barrier reef system

Science.gov (United States)

Davis, Kristen Alexis

The dynamics of internal waves shoaling on the Southeast Florida shelf and the resulting stratified turbulence in the shelf bottom boundary layer are investigated using observational studies completed during the summers of 2003-2005. This work is driven by a desire to understand the effects of internal wave-driven flow and the shoreward transport of cool, nutrient-rich water masses on cross-shelf exchange, vertical mixing, and mass transfer to benthic reef organisms. Shelf sea internal wave fields are typically highly variable and dominated by wind and tidal forces. However, this is not necessarily true for outer shelf regions or very narrow shelves where remote physical processes originating over the slope or deep ocean may exert a strong influence on the internal wave climate. During the summers of 2003 and 2004 observational studies were conducted to examine the effects of a western boundary current (the Florida Current), tides, and wind on the mean currents and internal wave field on the outer Southeast Florida shelf. We present evidence that suggests that the Florida Current plays as large a role in the determination of the high frequency internal wave field as tidal forces. These observations and analyses show that it is necessary to include the forcing from the Florida Current meanders and instabilities in order to predict accurately the episodic nature of the internal wave field on the Southeast Florida shelf. Deep ocean and continental shelf processes intersect at the shelf edge and influence the exchange of water masses and their associated characteristics including heat, nutrients, sediment, and larvae across the shelf. Thus, the dynamics of cross-shelf circulation have important consequences for organisms living on the shelf. In the second phase of this work, we investigate physical mechanisms controlling the exchange of water masses during the summer season across the Southeast Florida shelf. A time series of cross-shelf transport from May to August

Intracellular Water Exchange for Measuring the Dry Mass, Water Mass and Changes in Chemical Composition of Living Cells

Science.gov (United States)

Hecht, Vivian C.; Son, Sungmin; Li, Yingzhong; Knudsen, Scott M.; Olcum, Selim; Higgins, John M.; Chen, Jianzhu; Grover, William H.; Manalis, Scott R.

2013-01-01

We present a method for direct non-optical quantification of dry mass, dry density and water mass of single living cells in suspension. Dry mass and dry density are obtained simultaneously by measuring a cell’s buoyant mass sequentially in an H2O-based fluid and a D2O-based fluid. Rapid exchange of intracellular H2O for D2O renders the cell’s water content neutrally buoyant in both measurements, and thus the paired measurements yield the mass and density of the cell’s dry material alone. Utilizing this same property of rapid water exchange, we also demonstrate the quantification of intracellular water mass. In a population of E. coli, we paired these measurements to estimate the percent dry weight by mass and volume. We then focused on cellular dry density – the average density of all cellular biomolecules, weighted by their relative abundances. Given that densities vary across biomolecule types (RNA, DNA, protein), we investigated whether we could detect changes in biomolecular composition in bacteria, fungi, and mammalian cells. In E. coli, and S. cerevisiae, dry density increases from stationary to exponential phase, consistent with previously known increases in the RNA/protein ratio from up-regulated ribosome production. For mammalian cells, changes in growth conditions cause substantial shifts in dry density, suggesting concurrent changes in the protein, nucleic acid and lipid content of the cell. PMID:23844039

On line determination of deuterium in hydrogen water exchange reaction by mass spectrometry. IRP-10

International Nuclear Information System (INIS)

Sharma, J.D.; Alphonse, K.P.; Mishra, Sushama; Prabhu, S.A.; Mohan, Sadhana; Tangri, V.K.

2007-01-01

The Deuterium (D)/Hydrogen (H) analysis at low Concentration is generally carried out by Mass Spectrometry. Mass Spectrometer is specially designed for the measurement of Mass 2 and 3 ratio. The Deuterium analysis of water and hydrogen in concentration range of a few ppm to about 1% plays an important role in the Heavy Water Production Plants. For the enrichment of the Deuterium concentration in H 2 O by H 2 - H 2 O exchange a catalyst is essential as reaction is relatively slow. Heavy Water Division has developed in house Platinum based catalyst for the isotopic exchange of Hydrogen and Water

The Impact of the Applied Exchange Rate Regimes on the Internal Balance of Transition Countries

Directory of Open Access Journals (Sweden)

Vujanić Vlado

2017-12-01

Full Text Available One of the key goals of the economic policy makers of every country is to achieve internal and external balance. An unavoidable segment of the analysis concerning the achievement of internal and external balance is certainly the influence of the exchange rate regime applied in a country. European transition countries, despite their similar initial problems and final objectives, applied different exchange rate regimes adapted to the economic circumstances and needs of the country. The paper aims to examine and demonstrate the impact of the applied exchange rate regime on the internal balance of the transition countries. The research encompasses 10 representative transition countries, in the period from 2000-2014. The results of the research, from the aspect of internal balance, confirmed the justification of the application of the floating exchange rate regime in more developed, but not in less-developed, European transition countries. The application of floating exchange rate regimes in less-developed transition countries is associated with a considerably higher average inflation rate, which may be explained by the higher import dependence of lessdeveloped countries and by the consequent transfer of depreciation to price growth.

Research on the trend of Yen exchange rate and international crude oil price fluctuation affected by Japan’s earthquake

Directory of Open Access Journals (Sweden)

Xiaoguang Li

2014-05-01

Full Text Available Purpose: Whether this earthquake would become a turning point of the high oil price and whether it would have big impact on yen exchange rate are two issues to be discussed in this paper.Design/methodology/approach: To analyze deeply the internal relations between changes in yen exchange rate caused by Japan’s earthquake and price fluctuation of international crude oil, this research chooses middle rate of yen exchange rate during the 45 days around Japan’s earthquake and price data of international crude oil to do an empirical study, uses VAR model and HP trend decomposition to estimate the mutual effect of yen exchange rate change and price fluctuation of international crude oil in this period.Findings: It has been found in the empirical study with VAR model and HP filter decomposition model on the yen exchange rate and the international crude oil price fluctuation during 45 days around Japan’s earthquake that: the fluctuation of yen exchange rate around the earthquake is one of the main reasons for the drastic fluctuation of international crude oil price in that period. The fluctuation of international crude oil price directly triggered by yen exchange rate occupies 13.54% of its total variance. There is a long-term interactive relationship between yen exchange rate and international crude oil price. The upward trend of international crude oil price after the earthquake was obvious, while yen exchange rate remained relatively stable after the earthquake.Originality/value: As economic globalization goes deeper, the influence of natural disasters on international financial market and world economy will become more and more obvious. It has a great revelatory meaning to studying further each kind of natural disaster’s impacts on international financial market and world economics.

International Technology Exchange Division: 1993 Annual report

Energy Technology Data Exchange (ETDEWEB)

1993-12-31

The Office of Technology Development (OTD) was established to ensure that reliable and acceptable technologies are available for implementation at DOE sites and that a technically trained work force is available to complete the EM mission by 2019. OTD established the International Technology Exchange Staff (ITES) to identify, evaluate, and acquire international technologies which can accelerate US DOE cleanup operations. ITES`s goal is to pursue international collaboration among government organizations, educational institutions, and private industry to identify world-wide needs and available technologies that will meet US environmental needs in general, and EM cleanup needs in particular; and establish mechanisms by which US government ER/WM technologies will be transferred to the US private sector for commercialization and export to international markets. ITES has developed the following strategic objectives to implement its international goals: develop and implement EM`s policy for international programs in accordance with DOE and US Government policies and regulations; establish efficient and predictable international technology transfer mechanisms; assist the US private sector in the commercialization and deployment of federally funded EM technologies and related knowledge in international markets; leverage US and non-US resources to accelerate international development and regulatory acceptance of EM technologies; contribute to the improvement of EM`s training of US students, scientists, and managers on international environmental issues. A summary and descriptions of program activities and accomplishments are given for 17 programs which comprise the four main areas of the ITES program: Activities with the Former Soviet Union, International Technology Transfer, International Cooperation, and Information Systems and Publications. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database.

International Technology Exchange Division: 1993 Annual report

International Nuclear Information System (INIS)

1993-01-01

The Office of Technology Development (OTD) was established to ensure that reliable and acceptable technologies are available for implementation at DOE sites and that a technically trained work force is available to complete the EM mission by 2019. OTD established the International Technology Exchange Staff (ITES) to identify, evaluate, and acquire international technologies which can accelerate US DOE cleanup operations. ITES's goal is to pursue international collaboration among government organizations, educational institutions, and private industry to identify world-wide needs and available technologies that will meet US environmental needs in general, and EM cleanup needs in particular; and establish mechanisms by which US government ER/WM technologies will be transferred to the US private sector for commercialization and export to international markets. ITES has developed the following strategic objectives to implement its international goals: develop and implement EM's policy for international programs in accordance with DOE and US Government policies and regulations; establish efficient and predictable international technology transfer mechanisms; assist the US private sector in the commercialization and deployment of federally funded EM technologies and related knowledge in international markets; leverage US and non-US resources to accelerate international development and regulatory acceptance of EM technologies; contribute to the improvement of EM's training of US students, scientists, and managers on international environmental issues. A summary and descriptions of program activities and accomplishments are given for 17 programs which comprise the four main areas of the ITES program: Activities with the Former Soviet Union, International Technology Transfer, International Cooperation, and Information Systems and Publications. Selected papers are indexed separately for inclusion in the Energy Science and Technology Database

Probing protein interactions with hydrogen/deuterium exchange and mass spectrometry—A review

International Nuclear Information System (INIS)

Percy, Andrew J.; Rey, Martial; Burns, Kyle M.; Schriemer, David C.

2012-01-01

Highlights: ► Protein chemistry generates mass shifts useful for structure–function studies. ► H/DX supports a powerful mass shift method for protein interaction analysis. ► H/DX mass shifts are useful for determining binding data (K d , off-rates). ► Improved H/DX–MS workflows can accommodate complex protein systems. - Abstract: Assessing the functional outcome of protein interactions in structural terms is a goal of structural biology, however most techniques have a limited capacity for making structure–function determinations with both high resolution and high throughput. Mass spectrometry can be applied as a reader of protein chemistries in order to fill this void, and enable methodologies whereby protein structure–function determinations may be made on a proteome-wide level. Protein hydrogen/deuterium exchange (H/DX) offers a chemical labeling strategy suitable for tracking changes in “dynamic topography” and thus represents a powerful means of monitoring protein structure–function relationships. This review presents the exchange method in the context of interaction analysis. Applications involving interface detection, quantitation of binding, and conformational responses to ligation are discussed, and commentary on recent analytical developments is provided.

Spatially resolved protein hydrogen exchange measured by subzero-cooled chip-based nanoelectrospray ionization tandem mass spectrometry

DEFF Research Database (Denmark)

Amon, Sabine; Trelle, Morten B; Jensen, Ole N

2012-01-01

. After a given period of deuteration, the exchange reaction is quenched by acidification (pH 2.5) and cooling (0 °C) and the deuterated protein (or a digest thereof) is analyzed by mass spectrometry. The unavoidable loss of deuterium (back-exchange) that occurs under quench conditions is undesired...... as it leads to loss of information. Here we describe the successful application of a chip-based nanoelectrospray ionization mass spectrometry top-down fragmentation approach based on cooling to subzero temperature (-15 °C) which reduces the back-exchange at quench conditions to very low levels. For example...

The Influence of International Parity on the Exchange Rate: Purchasing Power Parity and International Fisher Effect

Directory of Open Access Journals (Sweden)

Oana Mionel

2012-02-01

Full Text Available This article assesses the impact of the inflationand interest rates on the exchange rates.The analysis tests the relation between the inflation rate and the exchange rate by applying thePurchasing Power Parity Theory, while the relationbetween the interest rate and the inflation rate istested by applying the International Fisher EffectTheory. In order to test the Purchasing Power Paritythe study takes into account the period of time between 1990 – 2009, and the following countries –the USA, Germany, the UK, Switzerland, Canada, Japan and China. As for testing the InternationalFisher Effect Theory the period of time is the same, 1990 – 2009, but a few countries are different –the USA, Germany, the UK, Switzerland, Canada, Australia and New Zeeland. Thus, both theoriesanalyse the USA as home country.

Further explorations of Skyrme-Hartree-Fock-Bogoliubov mass formulas. VIII. Role of Coulomb exchange

International Nuclear Information System (INIS)

Goriely, S.; Pearson, J. M.

2008-01-01

Following suggestions that the energy associated with Coulomb correlations and a possible charge-symmetry breaking of nuclear forces might largely cancel the Coulomb-exchange term, we refit the HFB-14 mass model without the Coulomb-exchange term to essentially all the mass data. The resulting mass model, HFB-15, gives a better fit to the 2149 mass data, σ rms falling from 0.729 to 0.678 MeV. The improvement in the energy differences between mirror nuclei is particularly striking: the Nolen-Schiffer anomaly, which is strong for HFB-14, is essentially eliminated. As for the extrapolation to highly neutron-rich nuclei, the HFB-15 model differs significantly from HFB-14, with up to 15 MeV less binding being predicted. However, the differences in the predicted values of differential quantities such as the neutron-separation energies, β-decay energies and fission barriers are very much smaller

The Influence of International Parity on the Exchange Rate: Purchasing Power Parity and International Fisher Effect

OpenAIRE

Oana Mionel

2012-01-01

This article assesses the impact of the inflation and interest rates on the exchange rates. The analysis tests the relation between the inflation rate and the exchange rate by applying the Purchasing Power Parity Theory, while the relation between the interest rate and the inflation rate is tested by applying the International Fisher Effect Theory. In order to test the Purchasing Power Parity the study takes into account the period of time between 1990 – 2009, and the following countries – th...

78 FR 6155 - Self-Regulatory Organizations; Miami International Securities Exchange LLC; Notice of Filing and...

Science.gov (United States)

2013-01-29

... virtually impossible for any exchange to identify, and thus assess fees such as an ORF on, each executing... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-68711; File No. SR-MIAX-2013-01] Self-Regulatory Organizations; Miami International Securities Exchange LLC; Notice of Filing and Immediate...

Dynamic mass exchange in doubly degenerate binaries. I - 0.9 and 1.2 solar mass stars

International Nuclear Information System (INIS)

Benz, W.; Cameron, A.G.W.; Press, W.H.; Bowers, R.L.

1990-01-01

The dynamic mass exchange process in doubly degenerate binaries was investigated using a three-dimensional numerical simulation of the evolution of a doubly degenerate binary system in which the primary is a 1.2-solar-mass white dwarf and the Roche lobe filling secondary is a 0.9-solar-mass dwarf. The results show that, in a little more than two orbital periods, the secondary is completely destroyed and transformed into a thick disk orbiting about the primary. Since only a very small fraction of the mass (0.0063 solar mass) escapes the system, the evolution of the binary results in the formation of a massive object. This object is composed of three parts, the initial white dwarf primary, a very hot pressure-supported spherical envelope, and a rotationally supported outer disk. The evolution of the system can be understood in terms of a simple analytical model where it is shown that the angular momentum carried by the mass during the transfer and stored in the disk determines the evolution of the system. 34 refs

Time-resolved pulsed hydrogen/deuterium exchange mass spectrometry probes gaseous proteins structural kinetics.

Science.gov (United States)

Rajabi, Khadijeh

2015-01-01

A pulsed hydrogen/deuterium exchange (HDX) method has been developed for rapid monitoring of the exchange kinetics of protein ions with D2O a few milliseconds after electrospray ionization (ESI). The stepwise gradual evolution of HDX of multiply charged protein ions was monitored using the pulsed HDX mass spectrometry technique. Upon introducing a very short pulse of D2O (in the μs to ms time scale) into the linear ion trap (LIT) of a time-of-flight (TOF) mass spectrometer, bimodal distributions were detected for the ions of cytochrome c and ubiquitin. Mechanistic details of HDX reactions for ubiquitin and cytochrome c in the gas phase were uncovered and the structural transitions were followed by analyzing the kinetics of HDX.

Events - France. Stock exchange. International; Actualite - France. Bourse. International

Energy Technology Data Exchange (ETDEWEB)

Anon,

2000-10-01

These columns made of short articles report on facts and events in the oil and gas industry in France and worldwide: 1 - France: increase of the production capacity of the ethylene oxide unit of BP's Lavera plant; the 'Plateaux-du-Vexin' gas pipeline crosses the Seine river; completion of the pumping of the front wreckage of the Erika tanker ship; Total inaugurates a vapor recovery unit at the Gonfreville l'Orcher refinery; a national energy saving plan for the abatement of the greenhouse effect; Sercel, a daughter company of Compagnie Generale de Geophysique (CGG), acquires Mark Products division of Shaw industries; the oil prices shoot the international trade; 2 - stock exchange: trend of market values in the context of oil crisis; 3 - international: important oil and gas strike made by TotalFinaElf and OKIOC (Offshore Kazakhstan International Operating Company) in Kazakhstan; communication: a new look for BP; status of Lukoil reserves in Russia; next round for the exploration of the Norwegian North Sea; Transocean Sedco Forex absorbs R and B Falcon Corp and becomes the first drilling contractor; ENI (Italy) becomes operator on the development of South Pars gas field (Iran) for the phases 4 and 5; Shell Overseas Investments BV, BP and Exxon Mobil have signed strategic alliance agreements with China Petroleum and Chemical Corp (Sinopec); first exploration permits for the Faeroe islands; different gas pricing rules for the industrialists in the different European countries. (J.S.)

Events - France. Stock exchange. International; Actualite - France. Bourse. International

Energy Technology Data Exchange (ETDEWEB)

Anon.

2000-10-01

These columns made of short articles report on facts and events in the oil and gas industry in France and worldwide: 1 - France: increase of the production capacity of the ethylene oxide unit of BP's Lavera plant; the 'Plateaux-du-Vexin' gas pipeline crosses the Seine river; completion of the pumping of the front wreckage of the Erika tanker ship; Total inaugurates a vapor recovery unit at the Gonfreville l'Orcher refinery; a national energy saving plan for the abatement of the greenhouse effect; Sercel, a daughter company of Compagnie Generale de Geophysique (CGG), acquires Mark Products division of Shaw industries; the oil prices shoot the international trade; 2 - stock exchange: trend of market values in the context of oil crisis; 3 - international: important oil and gas strike made by TotalFinaElf and OKIOC (Offshore Kazakhstan International Operating Company) in Kazakhstan; communication: a new look for BP; status of Lukoil reserves in Russia; next round for the exploration of the Norwegian North Sea; Transocean Sedco Forex absorbs R and B Falcon Corp and becomes the first drilling contractor; ENI (Italy) becomes operator on the development of South Pars gas field (Iran) for the phases 4 and 5; Shell Overseas Investments BV, BP and Exxon Mobil have signed strategic alliance agreements with China Petroleum and Chemical Corp (Sinopec); first exploration permits for the Faeroe islands; different gas pricing rules for the industrialists in the different European countries. (J.S.)

77 FR 15417 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Science.gov (United States)

2012-03-15

... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-66566; File No. SR-ISE-2012-21] Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of Proposed Rule Change Relating to a... Ownership Interest in ISE Holdings, Inc. to a Newly Formed Swiss Corporation, Eurex Global Derivatives AG...

Stochastic Discount Factor Approach to International Risk-Sharing: Evidence from Fixed Exchange Rate Episodes

NARCIS (Netherlands)

Hadzi-Vaskov, M.; Kool, C.J.M.

2007-01-01

This paper presents evidence of the stochastic discount factor approach to international risk-sharing applied to fixed exchange rate regimes. We calculate risk-sharing indices for two episodes of fixed or very rigid exchange rates: the Eurozone before and after the introduction of the Euro, and

75 FR 42801 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2010-07-22

... Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed... at or under the threshold are charged the constituent's prescribed execution fee. This waiver applies... members to execute large-sized FX options orders on the Exchange in a manner that is cost effective. The...

Comparative research of international exchange of plant products

Directory of Open Access Journals (Sweden)

Đorović Milutin T.

2003-01-01

Full Text Available The well known events which had taken place in our country over the period 1989-2001 provoked adverse effects on foreign trade exchange of the total economy, agriculture and commodities of plant origin. These effects and changes were analyzed using corresponding indices for the sub periods 1989-1992 and 1998-2001. The foreign trade exchange balance was substantially negative in both sub periods over the analyzed period showing an aggravating trend. Export covering import declined from 78.09% to only 47.71%. The positive balance of exchange of agricultural, especially commodities of plant origin in the first four years was turned into a negative balance of exchange in the second four years. Export covering import at the agricultural level declined from 164.79% to 78.58% and at the level of commodities of plant origin from 201,76% to 87.35%. There was a significant disturbance of commodity and regional structure exchange. The share of agriculture in the total export of the country was raised from 13.82% to 18.16%. The share of plant originating commodities in the total export of agriculture was raised from 71,96% to 86,34%. Basic agricultural products predominated in the export. In addition, in the domestic export the share of developed countries decreased which contributed to poor export results and increased the import dependence of the country. Considering the above said, the need arises to increase substantially agricultural production, i.e. commodities of plant origin. The structure and output of these productions should meet the needs of both domestic and foreign markets. International standards need to be applied in order to take hold of new foreign markets, exporting high technology processed products, using intensive and efficient promotive activities. Subsequently, greater investments and a planned production are needed, liberalization and especially the system of import control in foreign trade exchange of agricultural products, i

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

International Nuclear Information System (INIS)

Deng, Bin; Lento, Cristina; Wilson, Derek J.

2016-01-01

Protein therapeutics have emerged as a major class of biopharmaceuticals over the past several decades, a trend that has motivated the advancement of bioanalytical technologies for protein therapeutic characterization. Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful and sensitive technique that can probe the higher order structure of proteins and has been used in the assessment and development of monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs) and biosimilar antibodies. It has also been used to quantify protein-ligand, protein-receptor and other protein-protein interactions involved in signaling pathways. In manufacturing and development, HDX-MS can validate storage formulations and manufacturing processes for various biotherapeutics. Currently, HDX-MS is being refined to provide additional coverage, sensitivity and structural specificity and implemented on the millisecond timescale to reveal residual structure and dynamics in disordered domains and intrinsically disordered proteins. - Highlights: • The pharmaceuticals industry is increasingly shifting to protein therapeutics. • Hydrogen deuterium exchange mass spectrometry is uniquely well suited to support biopharmaceutical development. • Applications for hydrogen deuterium exchange span drug discovery, development and manufacturing. • Future developments will allow improved sensitivity, structural resolution and a broader range of dynamics to be monitored.

Hydrogen deuterium exchange mass spectrometry in biopharmaceutical discovery and development – A review

Energy Technology Data Exchange (ETDEWEB)

Deng, Bin, E-mail: dengbin@yorku.ca [Chemistry Department, York University, 4700 Keele Street, Toronto, ON, M3J 1P3 (Canada); The Centre for Research in Mass Spectrometry, York University, Toronto, ON, M3J1P3 (Canada); Lento, Cristina, E-mail: clento@yorku.ca [Chemistry Department, York University, 4700 Keele Street, Toronto, ON, M3J 1P3 (Canada); The Centre for Research in Mass Spectrometry, York University, Toronto, ON, M3J1P3 (Canada); Wilson, Derek J., E-mail: dkwilson@yorku.ca [Chemistry Department, York University, 4700 Keele Street, Toronto, ON, M3J 1P3 (Canada); The Centre for Research in Mass Spectrometry, York University, Toronto, ON, M3J1P3 (Canada)

2016-10-12

Protein therapeutics have emerged as a major class of biopharmaceuticals over the past several decades, a trend that has motivated the advancement of bioanalytical technologies for protein therapeutic characterization. Hydrogen deuterium exchange mass spectrometry (HDX-MS) is a powerful and sensitive technique that can probe the higher order structure of proteins and has been used in the assessment and development of monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs) and biosimilar antibodies. It has also been used to quantify protein-ligand, protein-receptor and other protein-protein interactions involved in signaling pathways. In manufacturing and development, HDX-MS can validate storage formulations and manufacturing processes for various biotherapeutics. Currently, HDX-MS is being refined to provide additional coverage, sensitivity and structural specificity and implemented on the millisecond timescale to reveal residual structure and dynamics in disordered domains and intrinsically disordered proteins. - Highlights: • The pharmaceuticals industry is increasingly shifting to protein therapeutics. • Hydrogen deuterium exchange mass spectrometry is uniquely well suited to support biopharmaceutical development. • Applications for hydrogen deuterium exchange span drug discovery, development and manufacturing. • Future developments will allow improved sensitivity, structural resolution and a broader range of dynamics to be monitored.

International technology exchange in support of the Defense Waste Processing Facility wasteform production

International Nuclear Information System (INIS)

Kitchen, B.G.

1989-01-01

The nearly completed Defense Waste Processing Facility (DWPF) is a Department of Energy (DOE) facility at the Savannah River Site that is designed to immobilize defense high level radioactive waste (HLW) by vitrification in borosilicate glass and containment in stainless steel canisters suitable for storage in the future DOE HLW repository. The DWPF is expected to start cold operation later this year (1990), and will be the first full scale vitrification facility operating in the United States, and the largest in the world. The DOE has been coordinating technology transfer and exchange on issues relating to HLW treatment and disposal through bi-lateral agreements with several nations. For the nearly fifteen years of the vitrification program at Savannah River Laboratory, over two hundred exchanges have been conducted with a dozen international agencies involving about five-hundred foreign national specialists. These international exchanges have been beneficial to the DOE's waste management efforts through confirmation of the choice of the waste form, enhanced understanding of melter operating phenomena, support for paths forward in political/regulatory arenas, confirmation of costs for waste form compliance programs, and establishing the need for enhancements of melter facility designs. This paper will compare designs and schedules of the international vitrification programs, and will discuss technical areas where the exchanges have provided data that have confirmed and aided US research and development efforts, impacted the design of the DWPF and guided the planning for regulatory interaction and product acceptance

Numerical analysis of the heat and mass transfer processes in selected M-Cycle heat exchangers for the dew point evaporative cooling

International Nuclear Information System (INIS)

Pandelidis, Demis; Anisimov, Sergey

2015-01-01

Highlights: • The comparative numerical study of the eight M-Cycle heat exchangers was presented. • The mathematical model is compared against the experimental data. • The results show, that the original M-Cycle heat and mass exchanger can be improved. • The effectiveness of the heat and mass exchangers depends strongly on the inlet air parameters. - Abstract: This paper investigates a mathematical simulation of heat and mass transfer in eight different types of the Maisotsenko Cycle (M-Cycle) heat and mass exchangers (HMXs) used for indirect evaporative air cooling. A two-dimensional heat and mass transfer model is developed to perform the thermal calculations of the indirect evaporative cooling process and quantifying the overall performance. The mathematical model was validated against experimental data. A numerical simulation reveals many unique features of the considered HMXs, enabling an accurate prediction of their performance. Results of the model allow for comparison of the analyzed devices in order to improve the performance of the original HMX

An international integration history of the Zagreb Stock Exchange

Directory of Open Access Journals (Sweden)

Luka Sikic

2017-06-01

Full Text Available We investigate stock market co-movements among the Croatian and several other markets (in the US, UK, Germany, Austria, Poland, Czech Republic and Hungary in the period from 3 September 1997 to 19 August 2016 with dynamic correlation coefficient models. This allows us to analyse long-term trends of the international financial integration of the Zagreb Stock Exchange in the last two decades as well as the separate impacts of major events that influenced financial markets during that period. Our results imply a relatively low level of international financial integration of the Croatian stock market, but some convergence in co-movement with the analysed markets over time is present. The strongest market co-movement is related to the subprime mortgage crisis, and EU accession seems to have made Croatian international integration less segmented.

Proceedings of the third international steam generator and heat exchanger conference

International Nuclear Information System (INIS)

1998-01-01

The Third International Steam Generator and Heat Exchanger conference had the objective to present the state of knowledge of steam generator performance and life management, and also heat exchanger technology. As this conference followed on from the previous conferences held in Toronto in 1990 and 1994, the emphasis was on recent developments, particularly those of the last 4 years. The conference provided an opportunity to operators, designers and researchers in the field of steam generation associated with electricity generation by nuclear energy to present their findings and exchange ideas. The conference endeavoured to do this over the widest possible range of subject areas, including: general operating experience, life management and fitness for service strategies, maintenance and inspection, thermalhydraulics, vibration, fretting and fatigue, materials, chemistry and corrosion and the regulatory issues

Proceedings of the third international steam generator and heat exchanger conference

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-07-01

The Third International Steam Generator and Heat Exchanger conference had the objective to present the state of knowledge of steam generator performance and life management, and also heat exchanger technology. As this conference followed on from the previous conferences held in Toronto in 1990 and 1994, the emphasis was on recent developments, particularly those of the last 4 years. The conference provided an opportunity to operators, designers and researchers in the field of steam generation associated with electricity generation by nuclear energy to present their findings and exchange ideas. The conference endeavoured to do this over the widest possible range of subject areas,including: general operating experience, life management and fitness for service strategies, maintenance and inspection, thermalhydraulics, vibration, fretting and fatigue, materials, chemistry and corrosion and the regulatory issues.

AN EXPERIMENTAL STUDY ON A VAPOR COMPRESSION REFRIGERATION CYCLE BY ADDING INTERNAL HEAT EXCHANGER

Directory of Open Access Journals (Sweden)

Muhammad Asmail Eleiwi

2013-05-01

Full Text Available Thispaper presents practical study to improve the indication COP of a vaporcompression refrigeration cycle in instrumented automobile air conditioner bydesigning internal heat exchanger and installing it in the vapor compressionrefrigeration cycle.  Two cases of  vapor compression refrigeration cycle were takenin this paper:  the first case is thatthe vapor compression refrigeration cycle without internal heat exchanger andin  the second case the vapor compressionrefrigeration cycle with heat exchanger ; in these two cases, the temperatureat each point of  a vapor compressionrefrigeration cycle, the low and the high pressure ,the indoor temperature andthe outdoor temperature were measured at each time at compressor speed 1450 rpmand 2900 rpm for each blower speed 1, blower speed 2 and blower speed 3.Therefrigerant fluid was used in the vapor compression refrigeration cycle withoutIHE and with IHE is R134a..

International Symposium for the Promotion of APEC Environmental Technology Exchange; APEC kankyo gijutsu koryu sokushin symposium

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-11-11

The International Symposium for the Promotion of APEC Environmental Technology Exchange was held under the theme `The function and role expected of the APEC Virtual Center,` with the objectives of clarifying the need for future intra-regional environmental technological exchange, defining the types of information and personnel exchange, and promoting the use of interactive character of the APEC Virtual Center for Environmental Technology Exchange by encouraging access to and participation in the Virtual Center project. It was held in the period of 11th and 12th, November in 1996, at the venue of Rinku International Convention Center in Osaka. The symposium was attended by 477 persons from nine countries, i.e., Australia, Canada, China, Indonesia, Korea, Philippines, Thailand, the US, and Japan, comprising staff members of intra-regional environment-related organizations. After the keynote speech, `Current status and tasks of environmental technology exchange`, and `Expected roles of the Virtual Center for Environmental Technology Exchange` were discussed. During the plenary session, the chairman summarized the symposium. This summary was carried on the Virtual Center homepage of the Internet

Developing additional capacity for wilderness management: An international exchange program between South Africa and United States wilderness rangers

Science.gov (United States)

Pierre van den Berg; Ralph Swain

2007-01-01

Wilderness managers have limited time to initiate international exchanges. Additionally, the benefits to developing capacity for wilderness management around the globe are not significant enough to make the effort cost-effective. International assistance, including wilderness management exchange programs, is critical to protecting wild areas around the globe. Former...

Academic performance and personal experience of local, international, and collaborative exchange students enrolled in an Australian pharmacy program.

Science.gov (United States)

Davey, Andrew K; Grant, Gary D; Anoopkumar-Dukie, Shailendra

2013-09-12

To assess the academic performance and experiences of local, international, and collaborative exchange students enrolled in a 4-year Australian bachelor of pharmacy degree program. Survey instruments exploring the demographics, background, and academic and cultural experiences of students during the program were administered in 2005 to students in all 4 years. Additionally, grades from each semester of the program for students (406 local, 70 international, 155 exchange) who graduated between 2002 and 2006 were analyzed retrospectively. The main differences found in the survey responses among the 3 groups were in students' motivations for choosing the degree program and school, with international and collaborative exchange students having put more thought into these decisions than local students. The average grades over the duration of the program were similar in all 3 demographic groups. However, local students slightly outperformed international students, particularly at the start of the year, whereas collaborative exchange students' grades mirrored those of local students during the 2 years prior to leaving their home country of Malaysia but more closely mirrored those of international students in the final 2 years after arriving on campus in Australia. Despite differences in academic backgrounds and culture, international and exchange students can perform well compared to local students in a bachelor of pharmacy program and were actually more satisfied than local students with the overall experience. Studying in a foreign country can negatively influence academic grades to a small extent and this is probably related to adjusting to the new environment.

75 FR 62900 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2010-10-13

...-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to a Market Maker Incentive Plan for Foreign Currency Options... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on October 4, 2010, International Securities...

76 FR 1488 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2011-01-10

...-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to a Market Maker Incentive Plan for Foreign Currency Options... Rule 19b-4 thereunder,\\2\\ notice is hereby given that on December 28, 2010, the International...

75 FR 2913 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2010-01-19

...-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and Immediate Effectiveness of Proposed Rule Change Relating to a Market Maker Incentive Plan for Foreign Currency Options...\\ and Rule 19b-4 thereunder,\\2\\ notice is hereby given that on December 31, 2009, the International...

On the vertical exchange of heat, mass and momentum over complex, mountainous terrain

Directory of Open Access Journals (Sweden)

Mathias Walter Rotach

2015-12-01

Full Text Available The role of the atmospheric boundary layer (ABL in the atmosphere-climate system is the exchange of heat, mass and momentum between ‘the earth’s surface’ and the atmosphere. Traditionally, it is understood that turbulent transport is responsible for this exchange and hence the understanding and physical description of the turbulence structure of the boundary layer is key to assess the effectiveness of earth-atmosphere exchange. This understanding is rooted in the (implicit assumption of a scale separation or spectral gap between turbulence and mean atmospheric motions, which in turn leads to the assumption of a horizontally homogeneous and flat (HHF surface as a reference, for which both physical understanding and model parameterizations have successfully been developed over the years. Over mountainous terrain, however, the ABL is generically inhomogeneous due to both thermal (radiative and dynamic forcing. This inhomogeneity leads to meso-scale and even sub-meso-scale flows such as slope and valley winds or wake effects. It is argued here that these (submeso-scale motions can significantly contribute to the vertical structure of the boundary layer and hence vertical exchange of heat and mass between the surface and the atmosphere. If model grid resolution is not high enough the latter will have to be parameterized (in a similar fashion as gravity wave drag parameterizations take into account the momentum transport due to gravity waves in large-scale models. In this contribution we summarize the available evidence of the contribution of (submeso-scale motions to vertical exchange in mountainous terrain from observational and numerical modeling studies. In particular, a number of recent simulation studies using idealized topography will be summarized and put into perspective – so as to identify possible limitations and areas of necessary future research.

77 FR 37944 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Science.gov (United States)

2012-06-25

... Organizations; International Securities Exchange, LLC; Notice of Filing of Proposed Rule Change To Allow Competitive Market Makers To Use Their Membership Points To Enter Multiple Quotes in an Options Class June 19... 19b-4 thereunder,\\2\\ notice is hereby given that on June 6, 2012, the International Securities...

Influence of concentration and hydrodynamic factors in sorption of iodine by anion-exchangers of the mass-transfer rate

International Nuclear Information System (INIS)

Sokolov, V.V.; Smirnov, N.N.

1982-01-01

An investigation of the joint influence of hydrodynamic and concentration factors in sorption of iodine by AV-17-8 and anion exchange resins on the mass-transfer coefficient is the subject of this report. The method of central composite rotatable experimental design was used for quantitative assessment and derivation of the appropriate equations. The investigation yielded the necessary regression equations satisfactorily describing the influence of all the factors in the mass-transfer coefficient. the optimal mass-transfer conditions were determined. On the basis of the values obtained, recommendations are made on the optimal hydrodynamic conditions of operation of equipment with pneumatic circulation of the ion-exchanger

Mass transfer model liquid phase catalytic exchange column simulation applicable to any column composition profile

Energy Technology Data Exchange (ETDEWEB)

Busigin, A. [NITEK USA Inc., Ocala, FL (United States)

2015-03-15

Liquid Phase Catalytic Exchange (LPCE) is a key technology used in water detritiation systems. Rigorous simulation of LPCE is complicated when a column may have both hydrogen and deuterium present in significant concentrations in different sections of the column. This paper presents a general mass transfer model for a homogenous packed bed LPCE column as a set of differential equations describing composition change, and equilibrium equations to define the mass transfer driving force within the column. The model is used to show the effect of deuterium buildup in the bottom of an LPCE column from non-negligible D atom fraction in the bottom feed gas to the column. These types of calculations are important in the design of CECE (Combined Electrolysis and Catalytic Exchange) water detritiation systems.

Numerical investigation of the energy performance of a guideless irregular heat and mass exchanger with corrugated heat transfer surface for dew point cooling

International Nuclear Information System (INIS)

Xu, Peng; Ma, Xiaoli; Diallo, Thierno M.O.; Zhao, Xudong; Fancey, Kevin; Li, Deying; Chen, Hongbing

2016-01-01

The paper presents an investigation into the energy performance of a novel irregular heat and mass exchanger for dew point cooling which, compared to the existing flat-plate heat exchangers, removed the use of the channel supporting guides and implemented the corrugated heat transfer surface, thus expecting to achieve the reduced air flow resistance, increased heat transfer area, and improved energy efficiency (i.e. Coefficient of Performance (COP)) of the air cooling process. CFD simulation was carried out to determine the flow resistance (K) factors of various elements within the dry and wet channels of the exchanger, while the ‘finite-element’ based ‘Newton-iteration’ numerical simulation was undertaken to investigate its cooling capacity, cooling effectiveness and COP at various geometrical and operational conditions. Compared to the existing flat-plate heat and mass exchangers with the same geometrical dimensions and operational conditions, the new irregular exchanger could achieve 32.9%–37% higher cooling capacity, dew-point and wet-bulb effectiveness, 29.7%–33.3% higher COP, and 55.8%–56.2% lower pressure drop. While undertaking dew point air cooling, the irregular heat and mass exchanger had the optimum air velocity of 1 m/s within the flow channels and working-to-intake air ratio of 0.3, which allowed the highest cooling capacity and COP to be achieved. In terms of the exchanger dimensions, the optimum height of the channel was 5 mm while its length was in the range 1–2 m. Overall, the proposed irregular heat and mass exchanger could lead to significant enhanced energy performance compared to the existing flat-plate dew point cooling heat exchanger of the same geometrical dimensions. To achieve the same amount cooling output, the irregular heat and mass exchanger had the reduced size and cost against the flat-plate ones. - Highlights: • Numerical investigation of an irregular heat and mass exchanger was undertaken. • A �

Hydrogen Exchange Mass Spectrometry of Functional Membrane-bound Chemotaxis Receptor Complexes

Science.gov (United States)

Koshy, Seena S.; Eyles, Stephen J.; Weis, Robert M.; Thompson, Lynmarie K.

2014-01-01

The transmembrane signaling mechanism of bacterial chemotaxis receptors is thought to involve changes in receptor conformation and dynamics. The receptors function in ternary complexes with two other proteins, CheA and CheW, that form extended membrane-bound arrays. Previous studies have shown that attractant binding induces a small (~2 Å) piston displacement of one helix of the periplasmic and transmembrane domains towards the cytoplasm, but it is not clear how this signal propagates through the cytoplasmic domain to control the kinase activity of the CheA bound at the membrane-distal tip, nearly 200 Å away. The cytoplasmic domain has been shown to be highly dynamic, which raises the question of how a small piston motion could propagate through a dynamic domain to control CheA kinase activity. To address this, we have developed a method for measuring dynamics of the receptor cytoplasmic fragment (CF) in functional complexes with CheA and CheW. Hydrogen exchange mass spectrometry (HDX-MS) measurements of global exchange of CF demonstrate that CF exhibits significantly slower exchange in functional complexes than in solution. Since the exchange rates in functional complexes are comparable to that of other proteins of similar structure, the CF appears to be a well-structured protein within these complexes, which is compatible with its role in propagating a signal that appears to be a tiny conformational change in the periplasmic and transmembrane domains of the receptor. We also demonstrate the feasibility of this protocol for local exchange measurements, by incorporating a pepsin digest step to produce peptides with 87% sequence coverage and only 20% back exchange. This method extends HDX-MS to membrane-bound functional complexes without detergents that may perturb the stability or structure of the system. PMID:24274333

Thoughts on the International Cooperation and Exchanges of Chinese Research Universities

Science.gov (United States)

Lu, Jiang-bin

2009-01-01

More prominent in the 21st century than ever are the internationalization of the competition for talents, the globalization of their mobility, and the diversity of the demand for them. This article analyzes the major features and content of the international cooperation and exchanges, and further discusses their tactics and measures in the process…

Mathematical Modeling of Non-Fickian Diffusional Mass Exchange of Radioactive Contaminants in Geological Disposal Formations

Directory of Open Access Journals (Sweden)

Anna Suzuki

2018-01-01

Full Text Available Deep geological repositories for nuclear wastes consist of both engineered and natural geologic barriers to isolate the radioactive material from the human environment. Inappropriate repositories of nuclear waste would cause severe contamination to nearby aquifers. In this complex environment, mass transport of radioactive contaminants displays anomalous behaviors and often produces power-law tails in breakthrough curves due to spatial heterogeneities in fractured rocks, velocity dispersion, adsorption, and decay of contaminants, which requires more sophisticated models beyond the typical advection-dispersion equation. In this paper, accounting for the mass exchange between a fracture and a porous matrix of complex geometry, the universal equation of mass transport within a fracture is derived. This equation represents the generalization of the previously used models and accounts for anomalous mass exchange between a fracture and porous blocks through the introduction of the integral term of convolution type and fractional derivatives. This equation can be applied for the variety of processes taking place in the complex fractured porous medium, including the transport of radioactive elements. The Laplace transform method was used to obtain the solution of the fractional diffusion equation with a time-dependent source of radioactive contaminant.

"One and the Same the World Over": The International Culture of Surgical Exchange in an Age of Globalization, 1870-1914.

Science.gov (United States)

Schlich, Thomas

2016-07-01

This paper examines the international exchange in surgery in the decades before World War I, a period of growing globalization in communication and transport. Focusing on Europe and North America, it looks first at the various means of exchange, especially surgical travel and the culture emerging around it and follows specific directions of exchange, from France and Britain, first to the German-speaking countries and finally to North America. Subsequently, the account turns to international organizations as an important means of exchange in this time period. The International Society of Surgery, in particular, provided a forum for a vivid internationalist discourse, which, however, stood in tension with simultaneous nationalist tendencies leading up to World War I. The paper finally discusses how the international exchange and communication at the time can be seen as an instance of modern surgeons claiming-and simultaneously trying to create-the global universality of surgical knowledge and practices, making sure that surgery is the same the world over. © The Author 2016. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Mathematical model development of heat and mass exchange processes in the outdoor swimming pool

OpenAIRE

M. V. Shaptala; D. E. Shaptala

2014-01-01

Purpose. Currently exploitation of outdoor swimming pools is often not cost-effective and, despite of their relevance, such pools are closed in large quantities. At this time there is no the whole mathematical model which would allow assessing qualitatively the effect of energy-saving measures. The aim of this work is to develop a mathematical model of heat and mass exchange processes for calculating basic heat and mass losses that occur during its exploitation. Methodology. The m...

Analysis of Critical Success Factors of Online International Learning Exchange of Korean School Pupils with English-Speaking Counterparts

Science.gov (United States)

Lee, Jong-Yeon; Park, Sanghoon

2017-01-01

This study identifies the factors influencing the success of online international learning exchange (ILE) among Korean school pupils who partnered with American and Australian pupils. In particular, it examined the effects of self-efficacy (SE), exchange infrastructure (EI) and quality of exchange activities (QEA) on the students' learning…

Internationally Safeguarded Atomic Fuel Exchange Center for the Asian Pacific Basin

International Nuclear Information System (INIS)

Selvaduray, G.; Anderson, R.N.; Goldstein, M.K.

1979-01-01

The concept of an Internationally Safeguarded Atomic Fuel Exchange Center (ISAFE) for the Asia-Pacific Basin is examined. The geography and nuclear capabilitiy of the countries that comprise the Asia-Pacific Basin is described in full length. The incentives and the limitations for the establishment of the ISAFE center in the Asia-Pacific Basin are discussed in detail. 34 refs

Mathematical model development of heat and mass exchange processes in the outdoor swimming pool

Directory of Open Access Journals (Sweden)

M. V. Shaptala

2014-12-01

Full Text Available Purpose. Currently exploitation of outdoor swimming pools is often not cost-effective and, despite of their relevance, such pools are closed in large quantities. At this time there is no the whole mathematical model which would allow assessing qualitatively the effect of energy-saving measures. The aim of this work is to develop a mathematical model of heat and mass exchange processes for calculating basic heat and mass losses that occur during its exploitation. Methodology. The method for determination of heat and mass loses based on the theory of similarity criteria equations is used. Findings. The main types of heat and mass losses of outdoor pool were analyzed. The most significant types were allocated and mathematically described. Namely: by evaporation of water from the surface of the pool, by natural and forced convection, by radiation to the environment, heat consumption for water heating. Originality. The mathematical model of heat and mass exchange process of the outdoor swimming pool was developed, which allows calculating the basic heat and mass loses that occur during its exploitation. Practical value. The method of determining heat and mass loses of outdoor swimming pool as a software system was developed and implemented. It is based on the mathematical model proposed by the authors. This method can be used for the conceptual design of energy-efficient structures of outdoor pools, to assess their use of energy-intensive and selecting the optimum energy-saving measures. A further step in research in this area is the experimental validation of the method of calculation of heat losses in outdoor swimming pools with its use as an example the pool of Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan. The outdoor pool, with water heating- up from the boiler room of the university, is operated year-round.

People's Republic of China in the International Technology Exchange

Directory of Open Access Journals (Sweden)

Alexander Igorevich Salitskiy

2015-12-01

Full Text Available The authors investigate the current state of the S&T in China in the context of its historical development and national policy in the sphere. The evaluation of the Chinese scientific and technological potential is based on some indicators of foreign trade as well as patent activity - in international comparisons. The trends in Chinese S&T sector and its role in the international technology transfers are viewed in the context of internationalization of the global economy. Today’s globally recognized achievements of China in trade in technology-intensive goods and services are based on a long history of rational state policy in acquisition and diffusion of foreign technology and expertise. This policy have resulted in the build-up of S&T system - which is already remarkably productive and keeps growing. One important and specific feature of China’s role in international exchange of high-tech goods and knowledge-intensive services is a growing self-capacity, and a lowering dependence on foreign sources (in relative terms.

Probing the Binding Interfaces of Protein Complexes Using Gas-Phase H/D Exchange Mass Spectrometry

DEFF Research Database (Denmark)

Mistarz, Ulrik H; Brown, Jeffery M; Haselmann, Kim F

2016-01-01

Fast gas-phase hydrogen/deuterium exchange mediated by ND3 gas and measured by mass spectrometry (gas-phase HDX-MS) is a largely unharnessed, fast, and sensitive method for probing primary- and higher-order polypeptide structure. Labeling of heteroatom-bound non-amide hydrogens in a sub-milliseco......Fast gas-phase hydrogen/deuterium exchange mediated by ND3 gas and measured by mass spectrometry (gas-phase HDX-MS) is a largely unharnessed, fast, and sensitive method for probing primary- and higher-order polypeptide structure. Labeling of heteroatom-bound non-amide hydrogens in a sub......-millisecond time span after electrospray ionization by ND3 gas can provide structural insights into protein conformers present in solution. Here, we have explored the use of gas-phase HDX-MS for probing the higher-order structure and binding interfaces of protein complexes originating from native solution...

“One and the Same the World Over”: The International Culture of Surgical Exchange in an Age of Globalization, 1870–1914

Science.gov (United States)

Schlich, Thomas

2016-01-01

This paper examines the international exchange in surgery in the decades before World War I, a period of growing globalization in communication and transport. Focusing on Europe and North America, it looks first at the various means of exchange, especially surgical travel and the culture emerging around it and follows specific directions of exchange, from France and Britain, first to the German-speaking countries and finally to North America. Subsequently, the account turns to international organizations as an important means of exchange in this time period. The International Society of Surgery, in particular, provided a forum for a vivid internationalist discourse, which, however, stood in tension with simultaneous nationalist tendencies leading up to World War I. The paper finally discusses how the international exchange and communication at the time can be seen as an instance of modern surgeons claiming—and simultaneously trying to create—the global universality of surgical knowledge and practices, making sure that surgery is the same the world over. PMID:26888942

Internal Mass Motion for Spacecraft Dynamics and Control

National Research Council Canada - National Science Library

Hall, Christopher D

2008-01-01

We present a detailed description of the application of a noncanonical Hamiltonian formulation to the modeling, analysis, and simulation of the dynamics of gyrostat spacecraft with internal mass motion...

Simultaneous determination of 13 carbohydrates using high-performance anion-exchange chromatography coupled with pulsed amperometric detection and mass spectrometry.

Science.gov (United States)

Zhao, Dan; Feng, Feng; Yuan, Fei; Su, Jin; Cheng, Yan; Wu, Hanqiu; Song, Kun; Nie, Bo; Yu, Lian; Zhang, Feng

2017-04-01

A simple, accurate, and highly sensitive method was developed for the determination of 13 carbohydrates in polysaccharide of Spirulina platensis based on high-performance anion-exchange chromatography coupled with pulsed amperometric detection and mass spectrometry. Samples were extracted with deionized water using ultrasonic-assisted extraction, and the ultrasound-assisted extraction conditions were optimized by Box-Behnken design. Then the extracted polysaccharide was hydrolyzed by adding 1 mol/L trifluoroacetic acid before determination by high-performance anion-exchange chromatography coupled with pulsed amperometric detection and confirmed by high-performance anion-exchange chromatography coupled with mass spectrometry. The high-performance anion-exchange chromatography coupled with pulsed amperometric detection method was performed on a CarboPac PA20 column by gradient elution using deionized water, 0.1 mol/L sodium hydroxide solution, and 0.4 mol/L sodium acetate solution. Excellent linearity was observed in the range of 0.05-10 mg/L. The average recoveries ranged from 80.7 to 121.7%. The limits of detection and limits of quantification for 13 carbohydrates were 0.02-0.10 and 0.2-1.2  μg/kg, respectively. The developed method has been successfully applied to ambient samples, and the results indicated that high-performance anion-exchange chromatography coupled with pulsed amperometric detection and mass spectrometry could provide a rapid and accurate method for the simultaneous determination of carbohydrates. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Non-equilibrium mass transfer absorption model for the design of boron isotopes chemical exchange column

International Nuclear Information System (INIS)

Bai, Peng; Fan, Kaigong; Guo, Xianghai; Zhang, Haocui

2016-01-01

Highlights: • We propose a non-equilibrium mass transfer absorption model instead of a distillation equilibrium model to calculate boron isotopes separation. • We apply the model to calculate the needed column height to meet prescribed separation requirements. - Abstract: To interpret the phenomenon of chemical exchange in boron isotopes separation accurately, the process is specified as an absorption–reaction–desorption hybrid process instead of a distillation equilibrium model, the non-equilibrium mass transfer absorption model is put forward and a mass transfer enhancement factor E is introduced to find the packing height needed to meet the specified separation requirements with MATLAB.

Platform dependencies in bottom-up hydrogen/deuterium exchange mass spectrometry.

Science.gov (United States)

Burns, Kyle M; Rey, Martial; Baker, Charles A H; Schriemer, David C

2013-02-01

Hydrogen-deuterium exchange mass spectrometry is an important method for protein structure-function analysis. The bottom-up approach uses protein digestion to localize deuteration to higher resolution, and the essential measurement involves centroid mass determinations on a very large set of peptides. In the course of evaluating systems for various projects, we established two (HDX-MS) platforms that consisted of a FT-MS and a high-resolution QTOF mass spectrometer, each with matched front-end fluidic systems. Digests of proteins spanning a 20-110 kDa range were deuterated to equilibrium, and figures-of-merit for a typical bottom-up (HDX-MS) experiment were compared for each platform. The Orbitrap Velos identified 64% more peptides than the 5600 QTOF, with a 42% overlap between the two systems, independent of protein size. Precision in deuterium measurements using the Orbitrap marginally exceeded that of the QTOF, depending on the Orbitrap resolution setting. However, the unique nature of FT-MS data generates situations where deuteration measurements can be inaccurate, because of destructive interference arising from mismatches in elemental mass defects. This is shown through the analysis of the peptides common to both platforms, where deuteration values can be as low as 35% of the expected values, depending on FT-MS resolution, peptide length and charge state. These findings are supported by simulations of Orbitrap transients, and highlight that caution should be exercised in deriving centroid mass values from FT transients that do not support baseline separation of the full isotopic composition.

Site-Specific Hydrogen Isotope Composition of Propane: Mass spectrometric methods, equilibrium temperature dependence, and kinetics of exchange

Science.gov (United States)

Xie, H.; Ponton, C.; Kitchen, N.; Lloyd, M. K.; Lawson, M.; Formolo, M. J.; Eiler, J. M.

2016-12-01

Intramolecular isotope ordering can constrain temperatures of synthesis, mechanisms of formation, and/or source substrates of organic compounds. Here we explore site-specific hydrogen isotope variations of propane. Statistical thermodynamic models predict that at equilibrium methylene hydrogen (-CH2-) in propane will be 10's of per mil higher in D/H ratio than methyl hydrogen (-CH3) at geologically relevant temperatures, and that this difference is highly temperature dependent ( 0.5-1 ‰/°C). Chemical-kinetic controls on site-specific D/H in propane could constrain the mechanisms, conditions and extents of propane synthesis or destruction. We have developed a method for measuring the difference in D/H ratio between methylene and methyl hydrogen in propane by gas source mass spectrometry. The data were measured using the Thermo Fisher Double Focusing Sector high resolution mass spectrometer (DFS), and involve comparison of the D/H ratios of molecular ion (C3H8+) and the ethyl fragmental ion (C2H5+). We demonstrate the accuracy and precision of this method through analysis of D-labeled and independently analyzed propanes. In the exchange experiments, propane was heated (100-200 oC) either alone or in the presence of D-enriched water (δD=1,1419 ‰ SMOW), with or without one of several potentially catalytic substrates for hours to weeks. Propane was found to exchange hydrogen with water vigorously at 200 °C in the presence of metal catalysts. In the presence of Ni catalyst, methylene hydrogen exchanges 2.5 times faster than methyl hydrogen. Hydrogen exchange in the presence of Pd catalyst is more effective and can equilibrate hydrogen isotope distribution on propane on the order of 7 days. Isotopic exchange in the presence of natural materials have also been tested, but is only measurable in the methylene group at 200 °C. High catalytic activity of Pd permits attainment of a bracketed, time-invariant equilibrium state that we use to calibrate the site

International information exchange in fusion research

International Nuclear Information System (INIS)

Strickler, C.S.

1979-01-01

Formal and informal agreements exist between the US and several other countries, assuring the unrestricted exchange of magnetic fusion information. The Fusion Energy Library at Oak Ridge National Laboratory uses the US Department of Energy standard distribution system and exchange agreements to ensure the receipt of current reports. Selective dissemination of information, computer networks, and exchange programs are additional means for information gathering. The importance of these means as they relate to the fusion program in the US and specifically at ORNL is discussed

Two-step ion-exchange chromatographic purification combined with reversed-phase chromatography to isolate C-peptide for mass spectrometric analysis.

Science.gov (United States)

Kabytaev, Kuanysh; Durairaj, Anita; Shin, Dmitriy; Rohlfing, Curt L; Connolly, Shawn; Little, Randie R; Stoyanov, Alexander V

2016-02-01

A liquid chromatography with mass spectrometry on-line platform that includes the orthogonal techniques of ion exchange and reversed phase chromatography is applied for C-peptide analysis. Additional improvement is achieved by the subsequent application of cation- and anion-exchange purification steps that allow for isolating components that have their isoelectric points in a narrow pH range before final reversed-phase mass spectrometry analysis. The utility of this approach for isolating fractions in the desired "pI window" for profiling complex mixtures is discussed. © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

International exchange of emergency phase information and assessments: an aid to inter/national decision makers

International Nuclear Information System (INIS)

Sullivan, T.J.

2003-01-01

plots via Internet web sites and interactively dialogue via web-based two-way televideo conferencing technology [LLNL/JAERI report]. While, in principle, the results were functional, the linkups proved to be rudimentary and somewhat unstable for combined video, voice and whiteboard interaction. JAERI (WSPEEDI) and LLNL (NARAC) did successfully exploit this project during two separate radiological accidents in Tokai, Japan. In 1999 the EU/RODOS project expressed an interest to join in this effort. In 2002 the USA renewed interest in this project and subsequently Russia/FEERC joined. Since 1999 there has been substantial improvement in Internet bandwidth, efficient and versatile data exchange protocols (e.g., XML) and televideo conferencing technology. Implementation of data exchange protocols (user ID and password protected) at those four major centers/projects in combination with a multi-party televideo conferencing capability provides the mechanism for the exchange of key information in near realtime, and examination and comparison of calculated assessments in a quasi-peer review mode. This capability provides the opportunity to detect missed input data as well as deficiencies in meteorology, resolution, topography, etc., thus leading to refinement, consensus and 'harmonization' in real time prior to the release of assessments to decision makers. Such a system should be a benefit to all the inter/national agencies involved in advising and protecting impacted citizens by reducing some of the information challenges they (the decision makers) face and, hopefully, resulting in consistent and presumably the best advice. We expect that with successful demonstration and experience with this system, in the future it could provide a tool to non-nuclear countries and international agencies such as the IAEA and WHO. (author)

Gas Chromatographic Mass Spectrometric Determination of Myo-inositol in Humans Utilizing a Deuterated Internal Standard

DEFF Research Database (Denmark)

Andersen, Jan Rud; Larsen, Elfinn; Harbo, Helge

1982-01-01

The isotopic dilution technique was used for determining the content of myo-inositol in human urine, plasma and haemolysed erythrocyte samples. A deuterated myo-inositol, synthesized from inosose-2 by base-catalysed exchange of hydrogens by deuterium, followed by reduction of the inosose with 2H2......, was added as internal standard to the samples at an early stage in the analytical procedure. After separation and derivatization to the hexa-acetate, the gas chromatographic mass spectrometric analysis was carried out. A 25 m fused silica capillary column coated with methyl silicone was used, and the ions...... selected for monitoring were m/z 210 and m/z 214, which are characteristic and abundant fragment ions from unlabelled and hexadeuterated myo-inositolhexa-acetate, respectively. Calibration curves from water, urine, plasma and haemolysed erythrocytes show parallel, linear responses in the ratio between...

Web-based international knowledge exchange tool on urban resilience and climate proofing cities : climatescan

NARCIS (Netherlands)

Boogaard, Floris; Tipping, Jonathan; Muthanna, T.; Duffy, A.; Bendall, Barry; Kluck, Jeroen

There is a wide diversity of projects undertaken to address urban resillience and climate proofing in the world. International knowledge exchange tools are evaluated with result: stakeholders demand tools that are interactive, open source and provide more detailed information (location, free photo

Heat exchanger

International Nuclear Information System (INIS)

Drury, C.R.

1988-01-01

A heat exchanger having primary and secondary conduits in heat-exchanging relationship is described comprising: at least one serpentine tube having parallel sections connected by reverse bends, the serpentine tube constituting one of the conduits; a group of open-ended tubes disposed adjacent to the parallel sections, the open-ended tubes constituting the other of the conduits, and forming a continuous mass of contacting tubes extending between and surrounding the serpentine tube sections; and means securing the mass of tubes together to form a predetermined cross-section of the entirety of the mass of open-ended tubes and tube sections

Slow Histidine H/D Exchange Protocol for Thermodynamic Analysis of Protein Folding and Stability using Mass Spectrometry

OpenAIRE

Tran, Duc T.; Banerjee, Sambuddha; Alayash, Abdu I.; Crumbliss, Alvin L.; Fitzgerald, Michael C.

2012-01-01

Described here is a mass spectrometry based protocol to study the thermodynamic stability of proteins and protein-ligand complexes using the slow H/D exchange reaction of the imidazole C2 proton in histidine side chains. The protocol, which involves evaluating the denaturant dependence of this slow H/D exchange reaction in proteins, allows the global and/or subglobal unfolding/refolding properties of proteins and protein-ligand complexes to be probed. The protocol is developed using several m...

INTERNATIONAL ENVIRONMENTAL TECHNOLOGY IDENTIFICATION, DEVELOPMENT, DEMONSTRATION, DEPLOYMENT AND EXCHANGE

Energy Technology Data Exchange (ETDEWEB)

Roy C. Herndon

2001-02-28

Cooperative Agreement (DE-FC21-95EW55101) between the U.S. Department of Energy (DOE) and the Florida State University's Institute for International Cooperative Environmental Research (IICER) was designed to facilitate a number of joint programmatic goals of both the DOE and the IICER related to international technology identification, development, demonstration and deployment using a variety of mechanisms to accomplish these goals. These mechanisms included: laboratory and field research; technology demonstrations; international training and technical exchanges; data collection, synthesis and evaluation; the conduct of conferences, symposia and high-level meetings; and other appropriate and effective approaches. The DOE utilized the expertise and facilities of the IICER at Florida State University to accomplish its goals related to this cooperative agreement. The IICER has unique and demonstrated capabilities that have been utilized to conduct the tasks for this cooperative agreement. The IICER conducted activities related to technology identification, development, evaluation, demonstration and deployment through its joint centers which link the capabilities at Florida State University with collaborating academic and leading research institutions in the major countries of Central and Eastern Europe (e.g., Czech Republic, Hungary, Poland) and Russia. The activities and accomplishments for this five-year cooperative agreement are summarized in this Final Technical Report.

Influence of inlet velocity of air and solid particle feed rate on holdup mass and heat transfer characteristics in cyclone heat exchanger

International Nuclear Information System (INIS)

Mothilal, T.; Pitchandi, K.

2015-01-01

Present work elaborates the effect of inlet velocity of air and solid particle feed rate on holdup mass and heat transfer characteristics in a cyclone heat exchanger. The RNG k-ε turbulence model was adopted for modeling high turbulence flow and Discrete phase model (DPM) to track solid particles in a cyclone heat exchanger by ANSYS FLUENT software. The effect of inlet air velocity (5 to 25 m/s) and inlet solid particle feed rate of (0.2 to 2.5 g/s) at different particle diameter (300 to 500 μm) on holdup mass and heat transfer rate in cyclone heat exchanger was studied at air inlet temperature of 473 K. Results show that holdup mass and heat transfer rate increase with increase in inlet air velocity and inlet solid particle feed rate. Influence of solid particle feed rate on holdup mass has more significance. Experimental setup was built for high efficiency cyclone. Good agreement was found between experimental and simulation pressure drop. Empirical correlation was derived for dimensionless holdup mass and Nusselt number based on CFD data by regression technique. Correlation predicts dimensional holdup mass with +5% to -8% errors of experimental data and Nusselt number with +9% to -3%

Influence of inlet velocity of air and solid particle feed rate on holdup mass and heat transfer characteristics in cyclone heat exchanger

Energy Technology Data Exchange (ETDEWEB)

Mothilal, T. [T. J. S. Engineering College, Gummidipoond (India); Pitchandi, K. [Sri Venkateswara College of Engineering, Sriperumbudur (India)

2015-10-15

Present work elaborates the effect of inlet velocity of air and solid particle feed rate on holdup mass and heat transfer characteristics in a cyclone heat exchanger. The RNG k-ε turbulence model was adopted for modeling high turbulence flow and Discrete phase model (DPM) to track solid particles in a cyclone heat exchanger by ANSYS FLUENT software. The effect of inlet air velocity (5 to 25 m/s) and inlet solid particle feed rate of (0.2 to 2.5 g/s) at different particle diameter (300 to 500 μm) on holdup mass and heat transfer rate in cyclone heat exchanger was studied at air inlet temperature of 473 K. Results show that holdup mass and heat transfer rate increase with increase in inlet air velocity and inlet solid particle feed rate. Influence of solid particle feed rate on holdup mass has more significance. Experimental setup was built for high efficiency cyclone. Good agreement was found between experimental and simulation pressure drop. Empirical correlation was derived for dimensionless holdup mass and Nusselt number based on CFD data by regression technique. Correlation predicts dimensional holdup mass with +5% to -8% errors of experimental data and Nusselt number with +9% to -3%.

Internal calibration on adjacent samples (InCAS) with Fourier transform mass spectrometry.

Science.gov (United States)

O'Connor, P B; Costello, C E

2000-12-15

Using matrix-assisted laser desorption/ionization (MAL DI) on a trapped ion mass spectrometer such as a Fourier transform mass spectrometer (FTMS) allows accumulation of ions in the cell from multiple laser shots prior to detection. If ions from separate MALDI samples are accumulated simultaneously in the cell, ions from one sample can be used to calibrate ions from the other sample. Since the ions are detected simultaneously in the cell, this is, in effect, internal calibration, but there are no selective desorption effects in the MALDI source. This method of internal calibration with adjacent samples is demonstrated here on cesium iodide clusters, peptides, oligosaccharides, poly(propylene glycol), and fullerenes and provides typical FTMS internal calibration mass accuracy of < 1 ppm.

Iodine-Containing Mass-Defect-Tuned Dendrimers for Use as Internal Mass Spectrometry Calibrants

Science.gov (United States)

Giesen, Joseph A.; Diament, Benjamin J.; Grayson, Scott M.

2018-03-01

Calibrants based on synthetic dendrimers have been recently proposed as a versatile alternative to peptides and proteins for both MALDI and ESI mass spectrometry calibration. Because of their modular synthetic platform, dendrimer calibrants are particularly amenable to tailoring for specific applications. Utilizing this versatility, a set of dendrimers has been designed as an internal calibrant with a tailored mass defect to differentiate them from the majority of natural peptide analytes. This was achieved by incorporating a tris-iodinated aromatic core as an initiator for the dendrimer synthesis, thereby affording multiple calibration points ( m/z range 600-2300) with an optimized mass-defect offset relative to all peptides composed of the 20 most common proteinogenic amino acids. [Figure not available: see fulltext.

Social Media and Population Health Virtual Exchange for Senior Nursing Students: An International Collaboration.

Science.gov (United States)

Procter, Paula M; Brixey, Juliana J; Honey, Michelle L L; Todhunter, Fern

2016-01-01

The authors have all engaged in using social media with students as a means for collaboration across national and international boundaries for various educational purposes. Following the explosion of big data in health the authors are now moving this concept forward within undergraduate and postgraduate nursing curricula for the development of population health virtual exchanges. Nursing has a global presence and yet it appears as though students have little knowledge of the health and social care needs and provision outside their local environment. This development will allow for explorative exchange amongst students in three countries, enhancing their understanding of their own and the selected international population health needs and solutions through asking and responding to questions amongst the learning community involved. The connection of the students will be recorded for their use in reflection; of particular interest will be the use of information included by the students to answer questions about their locality.

Internal humidifying of PEM [Proton Exchange Membrane] fuel cells

Energy Technology Data Exchange (ETDEWEB)

Staschewski, D [Karlsruhe Research Center (FZK), Karlsruhe (Germany). Inst. for Neutron Physics and Reactor Technics

1996-12-01

Hydrogen fuel cells (FC) for vehicular traction should stand out for a car-specific lightweight design. As regards PEMFC systems containing proton exchange membranes, this quality can be considerably improved by introducing porous bipolar plates which are conditioned by a water loop and deliver hot humidifying water to the adjacent membrane-electrode assembly (MEA). According to the principle of internal humidification here indicated special fuel cells based on sintered fiber and powder graphite were manufactured at FZK on a semi-technical scale. Self-made Pt/C electrodes hotpressed onto Nafion resulted in currents up to 200 A with pure oxygen as oxidant, providing the precondition for detailed studies of turnover and drainage rates within a monocell test arrangement. (author)

Recent insights from the international common-cause failure data exchange project

Energy Technology Data Exchange (ETDEWEB)

Kreuser, Albert [Gesellschaft fur Anlagen- und Reaktorsicherheit (GRS) gGmbH, Cologne (Germany); Johanson, Gunner [AF Industry, Stockholm (Sweden)

2017-03-15

Common-cause failure (CCF) events can significantly impact the availability of safety systems of nuclear power plants. For this reason, the International Common Cause Data Exchange (ICDE) project was initiated by several countries in 1994. Since 1997 it has been operated within the Organisation for Economic Co-operation and Development (OECD)/Nuclear Energy Agency (NEA) framework and has successfully been operated over six consecutive terms (the current term being 2015–2017). The ICDE project allows multiple countries to collaborate and exchange CCF data to enhance the quality of risk analyses, which include CCF modeling. As CCF events are typically rare, most countries do not experience enough CCF events to perform meaningful analyses. Data combined from several countries, however, have yielded sufficient data for more rigorous analyses. The ICDE project has meanwhile published 11 reports on the collection and analysis of CCF events of specific component types (centrifugal pumps, emergency diesel generators, motor operated valves, safety and relief valves, check valves, circuit breakers, level measurement, control rod drive assemblies, and heat exchangers) and two topical reports. This paper presents recent activities and lessons learnt from the data collection and the results of topical analysis on emergency diesel generator CCF impacting entire exposed population.

Recent Insights from the International Common-Cause Failure Data Exchange Project

Directory of Open Access Journals (Sweden)

Albert Kreuser

2017-03-01

Full Text Available Common-cause failure (CCF events can significantly impact the availability of safety systems of nuclear power plants. For this reason, the International Common Cause Data Exchange (ICDE project was initiated by several countries in 1994. Since 1997 it has been operated within the Organisation for Economic Co-operation and Development (OECD/Nuclear Energy Agency (NEA framework and has successfully been operated over six consecutive terms (the current term being 2015–2017. The ICDE project allows multiple countries to collaborate and exchange CCF data to enhance the quality of risk analyses, which include CCF modeling. As CCF events are typically rare, most countries do not experience enough CCF events to perform meaningful analyses. Data combined from several countries, however, have yielded sufficient data for more rigorous analyses. The ICDE project has meanwhile published 11 reports on the collection and analysis of CCF events of specific component types (centrifugal pumps, emergency diesel generators, motor operated valves, safety and relief valves, check valves, circuit breakers, level measurement, control rod drive assemblies, and heat exchangers and two topical reports. This paper presents recent activities and lessons learnt from the data collection and the results of topical analysis on emergency diesel generator CCF impacting entire exposed population.

Syntheses of deuterated leu-enkephalins and their use as internal standards for the quantification of leu-enkephalin by fast atom bombardment mass spectrometry

Energy Technology Data Exchange (ETDEWEB)

Benfenati, E. (Istituto di Ricerche Farmacologiche Mario Negri, Bergamo (Italy) Istituto di Ricerche Farmacologiche Mario Negri, Milan (Italy)); Icardi, G.; Chen, S. (Istituto di Ricerche Farmacologiche Mario Negri, Bergamo (Italy)); Fanelli, R. (Istituto di Ricerche Farmacologiche Mario Negri, Milan (Italy))

1990-04-01

We have developed a synthetic method for the preparation of di- and pentadeuterated leu-enkephalin (LE), Tyr-Gly-Gly-Phe-Leu, by proton-deuterium exchange using CF[sub 3]COOO[sup 2]H. Four to six deuterium atoms are introduced using a reaction temperature of 120[sup o]C and if 5% of [sup 2]H[sub 2]O is added the di-deuterated LE is obtained. These deuterated compounds are used as internal standards to plot calibration curves of LE using fast atom bombardment mass spectrometry. (author).

Threshold photoelectron--photonion coincidence mass spectrometric study of ethylene and ethylene-d4

International Nuclear Information System (INIS)

Stockbauer, R.; Inghram, M.G.

1975-01-01

Experimental curves have been obtained for the fragmentation of ethylene and ethylene-d 4 ions as a function of the internal energy of those ions using threshold photoelectron--photoion coincidence mass spectrometry. The results are compared with the previous results of photoionization mass spectrometry, He I photoelectron--photoion coicidence, charge exchange experiments, and with quasiequilibrium theory (QET) calculations. The discrepancies between results of these previous experiments and QET calculations do not appear in the present data. It is suggested that ion--molecule reactions competing with charge exchange has led to erroneous conclusions in the interpretation of the charge exchange data. It is concluded that QET does describe the fragmentation of ethylene and ethylene-d 4 within the limits of the data and calculations available. The secondary ion fragmentation C 2 H 4 + → C 2 H 3 + +H → C 2 H 2 + +2H is discussed in detail with regard to the C 2 H 3 + fragment ion internal energy distribution

Calcium isotope effects in ion exchange electromigration and calcium isotope analysis by thermo-ionization mass spectrometry

International Nuclear Information System (INIS)

Fujii, Y.; Hoshi, J.; Iwamoto, H.; Okamoto, M.; Kakihana, H.

1985-01-01

Calcium ions were made to electromigrate along a cation exchange membrane. The abundance ratios of the calcium isotopes (Ca-40, 42, 43, 44, 48) in the migrated bands were measured by thermo-ionization mass spectrometry. The lighter isotopes were enriched in the front part of the migrated band. The increments in the isotope abundance ratios were found to be proportional to the mass difference of the isotopes. The observed epsilon-values per unit mass difference (epsilon/ΔM) were 1.26 x 10 -4 (at 20 0 C), 1.85 x 10 -4 (at 25 0 C) and 2.4 x 10 -4 (at 40 0 C). The mass spectrometry was improved by using a low temperature for the evaporation of CaI 2 . (orig.)

Dynamic characterization of external and internal mass transport in heterotrophic biofilms from microsensors measurements.

Science.gov (United States)

Guimerà, Xavier; Dorado, Antonio David; Bonsfills, Anna; Gabriel, Gemma; Gabriel, David; Gamisans, Xavier

2016-10-01

Knowledge of mass transport mechanisms in biofilm-based technologies such as biofilters is essential to improve bioreactors performance by preventing mass transport limitation. External and internal mass transport in biofilms was characterized in heterotrophic biofilms grown on a flat plate bioreactor. Mass transport resistance through the liquid-biofilm interphase and diffusion within biofilms were quantified by in situ measurements using microsensors with a high spatial resolution (mass transport coefficients. The sensitivity of external and internal mass transport resistances to flow conditions within the range of typical fluid velocities over biofilms (Reynolds numbers between 0.5 and 7) was assessed. Estimated external mass transfer coefficients at different liquid phase flow velocities showed discrepancies with studies considering laminar conditions in the diffusive boundary layer near the liquid-biofilm interphase. The correlation of effective diffusivity with flow velocities showed that the heterogeneous structure of biofilms defines the transport mechanisms inside biofilms. Internal mass transport was driven by diffusion through cell clusters and aggregates at Re below 2.8. Conversely, mass transport was driven by advection within pores, voids and water channels at Re above 5.6. Between both flow velocities, mass transport occurred by a combination of advection and diffusion. Effective diffusivities estimated at different biofilm densities showed a linear increase of mass transport resistance due to a porosity decrease up to biofilm densities of 50 g VSS·L(-1). Mass transport was strongly limited at higher biofilm densities. Internal mass transport results were used to propose an empirical correlation to assess the effective diffusivity within biofilms considering the influence of hydrodynamics and biofilm density. Copyright © 2016 Elsevier Ltd. All rights reserved.

Electrochemical reduction of disulfide-containing proteins for hydrogen/deuterium exchange monitored by mass spectrometry

DEFF Research Database (Denmark)

Mysling, Simon; Salbo, Rune; Ploug, Michael

2014-01-01

Characterization of disulfide bond-containing proteins by hydrogen/deuterium exchange monitored by mass spectrometry (HDX-MS) requires reduction of the disulfide bonds under acidic and cold conditions, where the amide hydrogen exchange reaction is quenched (pH 2.5, 0 °C). The reduction typically...... of TCEP. In the present study, we explore the feasibility of using electrochemical reduction as a substitute for TCEP in HDX-MS analyses. Our results demonstrate that efficient disulfide bond reduction is readily achieved by implementing an electrochemical cell into the HDX-MS workflow. We also identify...... some challenges in using electrochemical reduction in HDX-MS analyses and provide possible conditions to attenuate these limitations. For example, high salt concentrations hamper disulfide bond reduction, necessitating additional dilution of the sample with aqueous acidic solution at quench conditions....

Standardizing exchange formats

International Nuclear Information System (INIS)

Lemmel, H.D.; Schmidt, J.J.

1992-01-01

An international network of co-operating data centres is described who maintain identical data bases which are simultaneously updated by an agreed data exchange procedure. The agreement covers ''data exchange formats'' which are compatible to the centres' internal data storage and retrieval systems which remain different, optimized at each centre to the available computer facilities and to the needs of the data users. Essential condition for the data exchange is an agreement on common procedures for the data exchange is an agreement on common procedures for the data compilation, including critical data analysis and validation. The systems described (''EXFOR'', ''ENDF'', ''CINDA'') are used for ''nuclear reaction data'', but the principles used for data compilation and exchange should be valid also for other data types. (author). 24 refs, 4 figs

The flushing and exchange of the South China Sea derived from salt and mass conservation

Science.gov (United States)

Liu, Yang; Bye, John A. T.; You, Yuzhu; Bao, Xianwen; Wu, Dexing

2010-07-01

In this paper, we use two kinds of hydrographic data, historical cruise data, Array for Real-time Geostrophic Oceanography (Argo) float data, and atmospheric data to study the water exchange between the South China Sea (SCS) and the Pacific Ocean through the Luzon Strait. The annual mean distributions of temperature and salinity at five different levels in the SCS and the adjacent Pacific Ocean are presented, which indicate the occurrence of active water exchange through the Luzon Strait. The flushing and exchange of the SCS are then determined by the application of salt and mass conservation in a multi-layered thermohaline system, using an estimate of the net rainfall obtained from reanalysis data. The results show that the annual mean flushing time is 44±8 months with an inflow rate of 11±2 Sv (1 Sv=10 6 m 3 s -1), part of which recirculates at a deeper level through the Luzon Strait, the remainder (6±2 Sv) forming the SCS throughflow. The diffusive influx of salt is also estimated and accounts for about 10% of the total influx, and hence advection dominates over diffusion in the water exchange through the Luzon Strait. The seasonal cycle of exchange shows a maximum in autumn and winter of about twice the annual mean rate.

International exchange of safety and licensing information

International Nuclear Information System (INIS)

Lafleur, J.D. Jr.; Hauber, R.D.; Chenier, D.M.

1977-01-01

A network of formal and informal bilateral arrangements for the exchange of nuclear safety information is being established by the U.S. Nuclear Regulatory Commission. For developing countries, such arrangements can provide ready access to the extensive, fully documented safety analyses and safety research results that NRC has accumulated. NRC has been receiving foreign visitors at a rate of about 500 per year, largely for discussions of safety and licensing questions related to light water reactors. Exchanges also are taking place on the safety of advanced reactors. A special interest of the NRC is in providing for reciprocal communicaion, at the earliest possible time, of important problems, decisions and other actions on nuclear safety matters. For example, it is essential that a newly-discovered problem in a nuclear reactor be brought immediately to the attention of other governments which are responsible for the safety of similar reactors. Definite progress has been made in the U.S. Freedom of Information Act. Certain exchanges have taken place on this basis. Experience in the establishment and operation of NRC's bilateral exchange arrangements is summarized. A typical exchange with the regulatory authority of country building its first power reactor is described

Ecological Unequal Exchange: International Trade and Uneven Utilization of Environmental Space in the World System

Science.gov (United States)

Rice, James

2007-01-01

We evaluate the argument that international trade influences disproportionate cross-national utilization of global renewable natural resources. Such uneven dynamics are relevant to the consideration of inequitable appropriation of environmental space in particular and processes of ecological unequal exchange more generally. Using OLS regression…

Marine Language Exchange Program: A 21st Century International and Interdisciplinary Partnership

Science.gov (United States)

Robigou, V.; Nichols-Pecceu, M.

2001-12-01

The ability of scientists to communicate across cultural and linguistic barriers is crucial for the global economic sustainability and protection of the world\\'{}s oceans. Yet students with majors in the sciences and engineering constitute less than 2% of those who study abroad each year. And even rarer are students who study in countries where English is not the first language. The Marine Language Exchange program is a case study of an international and interdisciplinary collaboration between faculties in the languages and the sciences who address this gap. A consortium of U.S. and European institutions including Eckerd College (Florida), University of Washington (Washington), University of Hilo (Hawaii), Université de la Rochelle (France), Université de Liège (Belgium), and Universidad de Las Palmas (Spain) is developing a multilingual, marine sciences exchange program in an effort to internationalize their Marine Sciences departments. The program includes a three-week, intensive "bridge" course designed to reinforce second language skills in the context of marine sciences, and prepare undergraduate students for the cultural and educational differences of their host country. Following this immersion experience students from each institution enroll in courses abroad including marine sciences specialization for full academic credit. This session will review the Marine Language Exchange program activities since 2000 and will discuss the ideological and practical aspects of the program. The program successes, difficulties and future directions will also be presented. Different disciplinary approaches -Second Language Acquisition, English as a Second Language and Marine Science- prepare science students to contribute to the study and the management of the world\\'{}s oceans with an awareness of the cultural issues reflected by national marine policies. Based on this case study, other universities could initiate their own international and interdisciplinary

Real-time hydrogen/deuterium exchange kinetics via supercharged electrospray ionization tandem mass spectrometry.

Science.gov (United States)

Sterling, Harry J; Williams, Evan R

2010-11-01

Amide hydrogen/deuterium exchange (HDX) rate constants of bovine ubiquitin in an ammonium acetate solution containing 1% of the electrospray ionization (ESI) "supercharging" reagent m-nitrobenzyl alcohol (m-NBA) were obtained using top-down, electron transfer dissociation (ETD) tandem mass spectrometry (MS). The supercharging reagent replaces the acid and temperature "quench" step in the conventional MS approach to HDX experiments by causing rapid protein denaturation to occur in the ESI droplet. The higher charge state ions that are produced with m-NBA are more unfolded, as measured by ion mobility, and result in higher fragmentation efficiency and higher sequence coverage with ETD. Single amino acid resolution was obtained for 44 of 72 exchangeable amide sites, and summed kinetic data were obtained for regions of the protein where adjacent fragment ions were not observed, resulting in an overall spatial resolution of 1.3 residues. Comparison of these results with previous values from NMR indicates that the supercharging reagent does not cause significant structural changes to the protein in the initial ESI solution and that scrambling or back-exchange is minimal. This new method for top-down HDX-MS enables real-time kinetic data measurements under physiological conditions, similar to those obtained using NMR, with comparable spatial resolution and significantly better sensitivity.

13th International Mass Spectrometry Conference. Book of Abstracts

International Nuclear Information System (INIS)

1994-01-01

The collection contains abstracts of several hundred papers presented at the international conference on new research and development results and applications of mass spectrometry. Abstracts falling into the INIS scope were indexed separately in the INIS database. (Roboz, P.)

13th International Mass Spectrometry Conference. Book of Abstracts

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

The collection contains abstracts of several hundred papers presented at the international conference on new research and development results and applications of mass spectrometry. Abstracts falling into the INIS scope were indexed separately in the INIS database. (Roboz, P.).

Ion mobility spectrometry-hydrogen deuterium exchange mass spectrometry of anions: part 1. Peptides to proteins.

Science.gov (United States)

Donohoe, Gregory C; Khakinejad, Mahdiar; Valentine, Stephen J

2015-04-01

Ion mobility spectrometry (IMS) coupled with hydrogen deuterium exchange (HDX)-mass spectrometry (MS) has been used to study the conformations of negatively-charged peptide and protein ions. Results are presented for ion conformers of angiotensin 1, a synthetic peptide (SP), bovine insulin, ubiquitin, and equine cytochrome c. In general, the SP ion conformers demonstrate a greater level of HDX efficiency as a greater proportion of the sites undergo HDX. Additionally, these ions exhibit the fastest rates of exchange. Comparatively, the angiotensin 1 ions exhibit a lower rate of exchange and HDX level presumably because of decreased accessibility of exchange sites by charge sites. The latter are likely confined to the peptide termini. Insulin ions show dramatically reduced HDX levels and exchange rates, which can be attributed to decreased conformational flexibility resulting from the disulfide bonds. For the larger ubiquitin and protein ions, increased HDX is observed for larger ions of higher charge state. For ubiquitin, a conformational transition from compact to more elongated species (from lower to higher charge states) is reflected by an increase in HDX levels. These results can be explained by a combination of interior site protection by compact conformers as well as decreased access by charge sites. The elongated cytochrome c ions provide the largest HDX levels where higher values correlate with charge state. These results are consistent with increased exchange site accessibility by additional charge sites. The data from these enhanced IMS-HDX experiments are described in terms of charge site location, conformer rigidity, and interior site protection.

Application of Atmospheric Pressure Photoionization H/D-exchange Mass Spectrometry for Speciation of Sulfur-containing Compounds.

Science.gov (United States)

Acter, Thamina; Kim, Donghwi; Ahmed, Arif; Ha, Ji-Hyoung; Kim, Sunghwan

2017-08-01

Herein we report the observation of atmospheric pressure in-source hydrogen-deuterium exchange (HDX) of thiol group for the first time. The HDX for thiol group was optimized for positive atmospheric pressure photoionization (APPI) mass spectrometry (MS). The optimized HDX-MS was applied for 31 model compounds (thiols, thiophenes, and sulfides) to demonstrate that exchanged peaks were observed only for thiols. The optimized method has been successfully applied to the isolated fractions of sulfur-rich oil samples. The exchange of one and two thiol hydrogens with deuterium was observed in the thiol fraction; no HDX was observed in the other fractions. Thus, the results presented in this study demonstrate that the HDX-MS method using APPI ionization source can be effective for speciation of sulfur compounds. This method has the potential to be used to access corrosion problems caused by thiol-containing compounds. Graphical Abstract ᅟ.

Report on a survey in fiscal 1999. International study exchange project; 1999 nendo kokusai kenkyu koryru jigyo chosa hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2000-03-01

Exchange with overseas researchers and research organizations has important significance in promoting research and development toward creating new research areas and structuring new technological systems intended for solving global environment problems. In cooperation with RITE and RITE researchers and relevant learned societies, researchers were invited or dispatched to international conferences and international symposiums with regard to global environment related technologies. In addition to interaction with major overseas research institutions and universities, medium and long-term dispatch and invitation have been performed that are considered to play an important role in future research exchange activities based on the achievements of short-term invitations and dispatches and examinations with potential research exchanges. As a result, domestic and overseas interactions on the latest researches were performed, while basic and applied researches related to global environment technologies are being proceeded also in various areas of studies outside the country. It was identified that these exchange activities have close relationship with research and development of industrial technologies serving for global environment preservation, which are being promoted by RITE. (NEDO)

A global probe into dental student perceptions about philanthropy, global dentistry and international student exchanges.

Science.gov (United States)

Ivanoff, Chris S; Yaneva, Krassimira; Luan, Diana; Andonov, Bogomil; Kumar, Reena R; Agnihotry, Anirudha; Ivanoff, Athena E; Emmanouil, Dimitrios; Volpato, Luiz Evaristo Ricci; Koneski, Filip; Muratovska, Ilijana; Al-Shehri, Huda A; Al-Taweel, Sara M; Daly, Michele

2017-04-01

Training culturally competent graduates who can practice effectively in a multicultural environment is a goal of contemporary dental education. The Global Oral Health Initiative is a network of dental schools seeking to promote global dentistry as a component of cultural competency training. Before initiating international student exchanges, a survey was conducted to assess students' awareness of global dentistry and interest in cross-national clerkships. A 22-question, YES/NO survey was distributed to 3,487 dental students at eight schools in seven countries. The questions probed students about their school's commitment to enhance their education by promoting global dentistry, volunteerism and philanthropy. The data were analysed using Vassarstats statistical software. In total, 2,371 students (67.9%) completed the survey. Cultural diversity was seen as an important component of dental education by 72.8% of the students, with two-thirds (66.9%) acknowledging that their training provided preparation for understanding the oral health care needs of disparate peoples. A high proportion (87.9%) agreed that volunteerism and philanthropy are important qualities of a well-rounded dentist, but only about one-third felt that their school supported these behaviours (36.2%) or demonstrated a commitment to promote global dentistry (35.5%). In addition, 87.4% felt that dental schools are morally bound to improve oral health care in marginalised global communities and should provide students with international exchange missions (91%), which would enhance their cultural competency (88.9%) and encourage their participation in charitable missions after graduation (67.6%). The study suggests that dental students would value international exchanges, which may enhance students' knowledge and self-awareness related to cultural competence. © 2016 FDI World Dental Federation.

International exchange of safety and licensing information

International Nuclear Information System (INIS)

Lafleur, J.D. Jr.; Hauber, R.D.; Chenier, D.M.

1977-01-01

A network of formal and informal bilateral arrangements for the exchange of nuclear safety information is being established by the US Nuclear Regulatory Commission. For developing countries such arrangements can provide ready access to the extensive, fully documented safety analyses and safety research results that USNRC has accumulated. USNRC has been receiving foreign visitors at a rate of about 500 per year, largely for discussions of safety and licensing questions related to light water reactors. Exchanges also are taking place on the safety of advanced reactors. A special interest of the USNRC is in providing for reciprocal communication, at the earliest possible time, of important problems, decisions and other actions on nuclear safety matters. For example, it is essential that a newly discovered problem in a nuclear reactor be brought immediately to the attention of other governments that are responsible for the safety of similar reactors. Definite progress has been made in the USA in defining categories of information that USNRC can receive in confidence from foreign countries, and can protect from disclosure under the US Freedom of Information Act. Certain exchanges have taken place on this basis. Experience in the establishment and operation of USNRC's bilateral exchange arrangements is summarized. A typical exchange with the regulatory authority of a country building its first power reactor is described. (author)

EXPERIMENTAL STUDY OF LOCAL HYDRODYNAMICS AND MASS EXCHANGE PROCESSES OF COOLANT IN FUEL ASSEMBLIES OF PRESSURIZED WATER REACTORS

Directory of Open Access Journals (Sweden)

S. M. Dmitriev

2016-01-01

Full Text Available The results of experimental studies of local hydrodynamics and mass exchange of coolant flow behind spacer and mixing grids of different structural versions that were developed for fuel assemblies of domestic and foreign nuclear reactors are presented in the article. In order to carry out the study the models of the following fuel assemblies have been fabricated: FA for VVER and VBER, FA-KVADRAT for PWR-reactor and FA for KLT-40C reactor. All the models have been fabricated with a full geometrical similarity with full-scale fuel assemblies. The study was carried out by simulating the flow of coolant in a core by air on an aerodynamic test rig. In order to measure local hydrodynamic characteristics of coolant flow five-channel Pitot probes were used that enable to measure the velocity vector in a point by its three components. The tracerpropane method was used for studying mass transfer processes. Flow hydrodynamics was studied by measuring cross-section velocities of coolant flow and coolant rates according to the model cells. The investigation of mass exchange processes consisted of a study of concentration distribution for tracer in experimental model, in determination of attenuation lengths of mass transfer processes behind mixing grids, in calculating of inter-cellar mass exchange coefficient. The database on coolant flow in fuel assemblies for different types of reactors had been accumulated that formed the basis of the engineering substantiation of reactor cores designs. The recommendations on choice of optimal versions of mixing grids have been taken into consideration by implementers of the JSC “OKBM Afrikantov” when creating commissioned fuel assemblies. The results of the study are used for verification of CFD-codes and CFD programs of detailed cell-by-cell calculation of reactor cores in order to decrease conservatism for substantiation of thermal-mechanical reliability.

CFD simulation of an internal spin-filter: evidence of lateral migration and exchange flow through the mesh.

Science.gov (United States)

Figueredo-Cardero, Alvio; Chico, Ernesto; Castilho, Leda R; Medronho, Ricardo A

2009-11-01

In the present work Computational Fluid Dynamics (CFD) was used to study the flow field and particle dynamics in an internal spin-filter (SF) bioreactor system. Evidence of a radial exchange flow through the filter mesh was detected, with a magnitude up to 130-fold higher than the perfusion flow, thus significantly contributing to radial drag. The exchange flow magnitude was significantly influenced by the filter rotation rate, but not by the perfusion flow, within the ranges evaluated. Previous reports had only given indirect evidences of this exchange flow phenomenon in spin-filters, but the current simulations were able to quantify and explain it. Flow pattern inside the spin-filter bioreactor resembled a typical Taylor-Couette flow, with vortices being formed in the annular gap and eventually penetrating the internal volume of the filter, thus being the probable reason for the significant exchange flow observed. The simulations also showed that cells become depleted in the vicinity of the mesh due to lateral particle migration. Cell concentration near the filter was approximately 50% of the bulk concentration, explaining why cell separation achieved in SFs is not solely due to size exclusion. The results presented indicate the power of CFD techniques to study and better understand spin-filter systems, aiming at the establishment of effective design, operation and scale-up criteria.

Mass fragmentographic analysis of total cholesterol in serum using a heptadeuterated internal standard

International Nuclear Information System (INIS)

Wolthers, B.G.; Hindriks, F.R.; Muskiet, F.A.J.; Groen, A.

1980-01-01

A mass fragmentographic method for the determination of total cholesterol in serum using heptadeuterated [25,26,26,26,27,27,27- 2 H] cholesterol as internal standard is presented. The results obtained are compared with a colorimetric and gas chromatographic method which were previously proposed as reference methods. Criteria for the development of absolute measurement by means of mass fragmentography and stable isotopically labelled internal standards are given. The conclusion is drawn that, at present, mass fragmentographic methods for the determination of total cholesterol in serum do not fulfil the criteria required for absolute methods. (Auth.)

Mathematical modeling of water mass balance for proton exchange membrane fuel cell

International Nuclear Information System (INIS)

Wan Ramli Wan Daud; Kamaruzzaman Sopian; Jaafar Sahari; Nik Suhaimi Mat Hassan

2006-01-01

Gas and water management are key to achieving good performance from a proton exchange membrane fuel cell (PEMFC) stack. Water plays a critical role in PEMFC. The proton conductivity is increase with the water content. In order to achieve enough hydration, water is normally introduced into the cell externally by a variety of methods such as liquid injection, steam introduction, and humidification of reactants by passing them through humidifiers before entering the cell. In this paper, mathematical modeling of water mass balance for PEMFC at anode and cathode side are proposed by using external humidification and assume that steady state, constant pressure, constant temperature and gases distribution are uniform

The origins of enhanced activity in factor VIIa analogs and the interplay between key allosteric sites revealed by hydrogen exchange mass spectrometry

DEFF Research Database (Denmark)

Rand, Kasper D; Andersen, Mette D; Olsen, Ole H

2008-01-01

Factor VIIa (FVIIa) circulates in the blood in a zymogen-like state. Only upon association with membrane-bound tissue factor (TF) at the site of vascular injury does FVIIa become active and able to initiate blood coagulation. Here we used hydrogen exchange monitored by mass spectrometry to invest......Factor VIIa (FVIIa) circulates in the blood in a zymogen-like state. Only upon association with membrane-bound tissue factor (TF) at the site of vascular injury does FVIIa become active and able to initiate blood coagulation. Here we used hydrogen exchange monitored by mass spectrometry...... to investigate the conformational effects of site-directed mutagenesis at key positions in FVIIa and the origins of enhanced intrinsic activity of FVIIa analogs. The differences in hydrogen exchange of two highly active variants, FVIIa(DVQ) and FVIIa(VEAY), imply that enhanced catalytic efficiency was attained...

Online Simultaneous Hydrogen/Deuterium Exchange of Multitarget Gas-Phase Molecules by Electrospray Ionization Mass Spectrometry Coupled with Gas Chromatography.

Science.gov (United States)

Jeong, Eun Sook; Cha, Eunju; Cha, Sangwon; Kim, Sunghwan; Oh, Han Bin; Kwon, Oh-Seung; Lee, Jaeick

2017-11-21

In this study, a hydrogen/deuterium (H/D) exchange method using gas chromatography-electrospray ionization/mass spectrometry (GC-ESI/MS) was first investigated as a novel tool for online H/D exchange of multitarget analytes. The GC and ESI source were combined with a homemade heated column transfer line. GC-ESI/MS-based H/D exchange occurs in an atmospheric pressure ion source as a result of reacting the gas-phase analyte eluted from GC with charged droplets of deuterium oxide infused as the ESI spray solvent. The consumption of the deuterated solvent at a flow rate of 2 μL min -1 was more economical than that in online H/D exchange methods reported to date. In-ESI-source H/D exchange by GC-ESI/MS was applied to 11 stimulants with secondary amino or hydroxyl groups. After H/D exchange, the spectra of the stimulants showed unexchanged, partially exchanged, and fully exchanged ions showing various degrees of exchange. The relative abundances corrected for naturally occurring isotopes of the fully exchanged ions of stimulants, except for etamivan, were in the range 24.3-85.5%. Methylephedrine and cyclazodone showed low H/D exchange efficiency under acidic, neutral, and basic spray solvent conditions and nonexchange for etamivan with an acidic phenolic OH group. The in-ESI-source H/D exchange efficiency by GC-ESI/MS was sufficient to determine the number of hydrogen by elucidation of fragmentation from the spectrum. Therefore, this online H/D exchange technique using GC-ESI/MS has potential as an alternative method for simultaneous H/D exchange of multitarget analytes.

Multi-layer membrane model for mass transport in a direct ethanol fuel cell using an alkaline anion exchange membrane

Science.gov (United States)

Bahrami, Hafez; Faghri, Amir

2012-11-01

A one-dimensional, isothermal, single-phase model is presented to investigate the mass transport in a direct ethanol fuel cell incorporating an alkaline anion exchange membrane. The electrochemistry is analytically solved and the closed-form solution is provided for two limiting cases assuming Tafel expressions for both oxygen reduction and ethanol oxidation. A multi-layer membrane model is proposed to properly account for the diffusive and electroosmotic transport of ethanol through the membrane. The fundamental differences in fuel crossover for positive and negative electroosmotic drag coefficients are discussed. It is found that ethanol crossover is significantly reduced upon using an alkaline anion exchange membrane instead of a proton exchange membrane, especially at current densities higher than 500 A m

Improving mass measurement accuracy in mass spectrometry based proteomics by combining open source tools for chromatographic alignment and internal calibration.

Science.gov (United States)

Palmblad, Magnus; van der Burgt, Yuri E M; Dalebout, Hans; Derks, Rico J E; Schoenmaker, Bart; Deelder, André M

2009-05-02

Accurate mass determination enhances peptide identification in mass spectrometry based proteomics. We here describe the combination of two previously published open source software tools to improve mass measurement accuracy in Fourier transform ion cyclotron resonance mass spectrometry (FTICRMS). The first program, msalign, aligns one MS/MS dataset with one FTICRMS dataset. The second software, recal2, uses peptides identified from the MS/MS data for automated internal calibration of the FTICR spectra, resulting in sub-ppm mass measurement errors.

Internal Flow Management in a Multi-Zone Climate Control Unit

NARCIS (Netherlands)

Persis, C. De; Jessen, J.J.; Izadi-Zamanabadi, R.; Schiøler, H.

2006-01-01

In this contribution, we examine a dynamic model describing the evolution of internal climate conditions in a closed environment partitioned into zones for which different climate conditions must be guaranteed. The zones are not separated, large air masses are exchanged among them, and the behavior

Internal flow management in a multi-zone climate control unit

DEFF Research Database (Denmark)

De Persis, C.; Jessen, Jan Jacob; Izadi-Zamanabadi, Roozbeh

2006-01-01

In this contribution, we examine a dynamic model describing the evolution of internal climate conditions in a closed environment partitioned into zones for which different climate conditions must be guaranteed. The zones are not separated, large air masses are exchanged among them, and the behavior...

Abstracts of international symposium on heat and mass transfer under plasma conditions

International Nuclear Information System (INIS)

1994-01-01

The international symposium on heat and mass transfer under plasma conditions was held on 4-8 July 1994 in Cesme, Izmir, Turkey. The spesialists discussed heat and mass transfer in the field of plasma processing at the meeting. More than 70 papers were presented in the meeting

Abstracts of international symposium on heat and mass transfer under plasma conditions

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-12-31

The international symposium on heat and mass transfer under plasma conditions was held on 4-8 July 1994 in Cesme, Izmir, Turkey. The spesialists discussed heat and mass transfer in the field of plasma processing at the meeting. More than 70 papers were presented in the meeting.

Next Generation Microchannel Heat Exchangers

CERN Document Server

Ohadi, Michael; Dessiatoun, Serguei; Cetegen, Edvin

2013-01-01

In Next Generation Microchannel Heat Exchangers, the authors’ focus on the new generation highly efficient heat exchangers and presentation of novel data and technical expertise not available in the open literature.  Next generation micro channels offer record high heat transfer coefficients with pressure drops much less than conventional micro channel heat exchangers. These inherent features promise fast penetration into many mew markets, including high heat flux cooling of electronics, waste heat recovery and energy efficiency enhancement applications, alternative energy systems, as well as applications in mass exchangers and chemical reactor systems. The combination of up to the minute research findings and technical know-how make this book very timely as the search for high performance heat and mass exchangers that can cut costs in materials consumption intensifies.

Speciation of eight arsenic compounds in human urine by high performance liquid chromatography with inductively coupled plasma mass spectrometric detection using antimonate for internal chromatographic standardization

DEFF Research Database (Denmark)

Larsen, Erik Huusfeldt; Pritzl, G.; Hansen, S. H.

1993-01-01

Four anionic and four cationic arsenic compounds in urine were separated by anion- and cation-exchange high-performance liquid chromatography and detected by inductively coupled plasma mass spectrometry (ICP-MS) at m/z 75. The species were the anions arsenite, arsenate, monomethylarsonate...... and dimethylarsinate and the cations arsenobetaine, trimethylarsine oxide, arsenocholine and the tetramethylarsonium ion. Hexahydroxyantimonate(III) was co-chromatographed with the arsenic anions but detected at m/z 121 and used as an internal standard for their qualitative analysis. Arsenite was prone to oxidation....... The argon chloride interference at m/z 75 was eliminated by chromatographic separation of the chloride present in the sample from the arsenic analytes. The ClO+ ion detected at m/z 51 and 53 was used to monitor the retention time of chloride in the anion-exchange system. The chloride eluted about 100 s...

Energy performance of an innovative liquid desiccant dehumidification system with a counter-flow heat and mass exchanger using potassium formate

DEFF Research Database (Denmark)

Jradi, Muhyiddine; Riffat, Saffa

2014-01-01

An innovative micro-scale liquid desiccant dehumidification system is numerically investigated. The liquid desiccant dehumidification unit employs a counter-flow low-cost and efficient heat and mass exchange core, improving the thermal performance and eliminating desiccant carryover...... that the dehumidifier effectiveness is directly proportional to the intake air temperature, intake air relative humidity and liquid desiccant flow rate where the effectiveness is inversely proportional to the intake air velocity and the heat exchanger air channel height....

Development and application of out-of-focus imaging in order to characterize heat and mass exchanges in two-phase flows

International Nuclear Information System (INIS)

Lemaitre, P.; Porcheron, E.; Marchand, D.; Nuboer, A.; Bouilloux, L.; Vendel, J.

2007-01-01

The aim of this paper is to present the capacity of the out-of-focus imaging in order to measure droplets size in presence of heat and mass exchanges. It is supported with optical simulations first based on geometrical optics, and then with the Lorenz-Mie theory. Finally, this technique is applied in presence of heat and mass transfers in the TOSQAN experiment. (authors)

Conformational analysis of g protein-coupled receptor signaling by hydrogen/deuterium exchange mass spectrometry.

Science.gov (United States)

Li, Sheng; Lee, Su Youn; Chung, Ka Young

2015-01-01

Conformational change and protein-protein interactions are two major mechanisms of membrane protein signal transduction, including G protein-coupled receptors (GPCRs). Upon agonist binding, GPCRs change conformation, resulting in interaction with downstream signaling molecules such as G proteins. To understand the precise signaling mechanism, studies have investigated the structural mechanism of GPCR signaling using X-ray crystallography, nuclear magnetic resonance (NMR), or electron paramagnetic resonance. In addition to these techniques, hydrogen/deuterium exchange mass spectrometry (HDX-MS) has recently been used in GPCR studies. HDX-MS measures the rate at which peptide amide hydrogens exchange with deuterium in the solvent. Exposed or flexible regions have higher exchange rates and excluded or ordered regions have lower exchange rates. Therefore, HDX-MS is a useful tool for studying protein-protein interfaces and conformational changes after protein activation or protein-protein interactions. Although HDX-MS does not give high-resolution structures, it analyzes protein conformations that are difficult to study with X-ray crystallography or NMR. Furthermore, conformational information from HDX-MS can help in the crystallization of X-ray crystallography by suggesting highly flexible regions. Interactions between GPCRs and downstream signaling molecules are not easily analyzed by X-ray crystallography or NMR because of the large size of the GPCR-signaling molecule complexes, hydrophobicity, and flexibility of GPCRs. HDX-MS could be useful for analyzing the conformational mechanism of GPCR signaling. In this chapter, we discuss details of HDX-MS for analyzing GPCRs using the β2AR-G protein complex as a model system. © 2015 Elsevier Inc. All rights reserved.

International petroleum enviromental conference (IPEC) offers opportunity for exchange of ideas

International Nuclear Information System (INIS)

Veil, J.A.; Spiric, Z.

2001-01-01

Oil and gas are produced in many parts of the world. Persons working in the petroleum industry can learn much by communicating with colleagues in other countries, but the opportunities for engineers and scientists to come together and discuss petroleum environmental control practices, technologies, and regulations with representatives of other countries are limited. This paper describes the very useful International Petroleum Environmental Conference (IPEC) which completed its seventh meeting in November 2000 in Albuquerque, New Mexico, USA. The 7th IPEC attracted 350 participants, including 26 participants from countries other than the United States. The 7th IPEC emphasized international issues and included more than 20 papers by international authors or on international topics. The conference covered all aspects of petroleum environmental issues and featured speakers from many disciplines. The conference included technical sessions on the following topics: Legal and Regulatory Issues in the Oil and Gas Industry; Pollution Prevention, Waste Management, and Waste Minimization; Bioremediation of Petroleum Hydrocarbons; Characterization and Remediation of Brine-Impacted Soils; Biotreatment and Bioremediation; International Issues in the Oil and Gas Industry; Phytoremediation of Petroleum Hydrocarbons; Treatment and Management of Produced Water; Forensic Geochemistry and Site Characterization/Technology Transfer; Environmentall Acceptable Endpoints; Desulfurization of Fuels and Waste Streams; Control of Air Emissions; MTBE/Phytoremediation and Natural Attenuation; and Treatment and Remediation of Petroleum Hydrocarbons. The last day of the conference was devoted to a special symposium on 'Innovative Technologies for Subsurface Characterization and Remediation.' The authors recommend this conference as a forum for industry, government, and academia to freely exchange ideas and information

An Experimentally Validated Numerical Modeling Technique for Perforated Plate Heat Exchangers.

Science.gov (United States)

White, M J; Nellis, G F; Kelin, S A; Zhu, W; Gianchandani, Y

2010-11-01

Cryogenic and high-temperature systems often require compact heat exchangers with a high resistance to axial conduction in order to control the heat transfer induced by axial temperature differences. One attractive design for such applications is a perforated plate heat exchanger that utilizes high conductivity perforated plates to provide the stream-to-stream heat transfer and low conductivity spacers to prevent axial conduction between the perforated plates. This paper presents a numerical model of a perforated plate heat exchanger that accounts for axial conduction, external parasitic heat loads, variable fluid and material properties, and conduction to and from the ends of the heat exchanger. The numerical model is validated by experimentally testing several perforated plate heat exchangers that are fabricated using microelectromechanical systems based manufacturing methods. This type of heat exchanger was investigated for potential use in a cryosurgical probe. One of these heat exchangers included perforated plates with integrated platinum resistance thermometers. These plates provided in situ measurements of the internal temperature distribution in addition to the temperature, pressure, and flow rate measured at the inlet and exit ports of the device. The platinum wires were deposited between the fluid passages on the perforated plate and are used to measure the temperature at the interface between the wall material and the flowing fluid. The experimental testing demonstrates the ability of the numerical model to accurately predict both the overall performance and the internal temperature distribution of perforated plate heat exchangers over a range of geometry and operating conditions. The parameters that were varied include the axial length, temperature range, mass flow rate, and working fluid.

The impact of risk management on internal and sustainable growth rate: Evidence from Tehran Stock Exchange

Directory of Open Access Journals (Sweden)

Hamid Reza Vakili Fard

2014-09-01

Full Text Available Measuring the relative risk of firms has been an open discussion among researchers. There are many studies on learning how leverage may influence on growth of the firms. This article reviews the relationship between risk management, internal and sustainable growth of accepted companies in Tehran stock exchange. The survey considers three types of risks including operating, financial and compound and investigates their relationships with internal growth rate as well as sustainable growth rate. Using some regression techniques, the study has determined negative and meaningful relationships between different types of leverage on side and internal as well as sustainable growth on the other side.

Numerical study of a novel counter-flow heat and mass exchanger for dew point evaporative cooling

Energy Technology Data Exchange (ETDEWEB)

Zhao, X.; Riffat, S.B. [School of the Built Environment, University of Nottingham, University Park, Nottingham NG7 2RD (United Kingdom); Li, J.M. [Department of Thermal Engineering, Key Laboratory for Thermal Science and Power Engineering of Ministry of Education, Tsinghua University, Beijing 100084 (China)

2008-10-15

The paper presents numerical investigation of a novel counter-flow heat and mass exchanger used in the indirect evaporative dew point cooling systems, a potential alternative to the conventional mechanical compression air conditioning systems. Numeric simulation was carried out to optimise the geometrical sizes and operating conditions of the exchanger in order to enhance the cooling (dew point and wet bulb) effectiveness of the exchanger and maximise the energy efficiency of the dew point cooling system. The results of the simulations indicated that cooling (dew point and wet bulb) effectiveness and energy efficiency are largely dependent on the dimensions of the airflow passages, air velocity and working-to-intake-air ratio, and less dependent on the temperature of the feed water. It is recommended that exchanger intake air velocity should be controlled to a value below 0.3-0.5 m/s; height of air passage (channel) should be set to 6 mm or below and the length of the passage should be 200 time the height; the working-to-intake-air ratio should be around 0.4. Under the UK summer design condition, i.e., 28{sup o}C of dry bulb temperature, 20{sup o}C of wet bulb temperature and 16{sup o}C of dew point temperature, the exchanger can achieve wet-bulb effectiveness of up to 1.3 and dew-point effectiveness of up to 0.9. (author)

Temperature- and body mass-related variation in cyclic gas exchange characteristics and metabolic rate of seven weevil species: Broader implications.

Science.gov (United States)

Klok, C J; Chown, S L

2005-07-01

The influence of temperature on metabolic rate and characteristics of the gas exchange patterns of flightless, sub-Antarctic Ectemnorhinus-group species from Heard and Marion islands was investigated. All of the species showed cyclic gas exchange with no Flutter period, indicating that these species are not characterized by discontinuous gas exchange cycles. Metabolic rate estimates were substantially lower in this study than in a previous one of a subset of the species, demonstrating that open-system respirometry methods provide more representative estimates of standard metabolic rate than do many closed-system methods. We recommend that the latter, and especially constant-pressure methods, either be abandoned for estimates of standard metabolic rate in insects, or have their outputs subject to careful scrutiny, given the wide availability of the former. V(.)CO(2) increase with an increase in temperature (range: 0-15 degrees C) was modulated by an increase in cycle frequency, but typically not by an increase in burst volume. Previous investigations of temperature-related changes in cyclic gas exchange (both cyclic and discontinuous) in several other insect species were therefore substantiated. Interspecific mass-scaling of metabolic rate (ca. 0.466-0.573, excluding and including phylogenetic non-independence, respectively) produced an exponent lower than 0.75 (but not distinguishable from it or from 0.67). The increase of metabolic rate with mass was modulated by an increase in burst volume and not by a change in cycle frequency, in keeping with investigations of species showing discontinuous gas exchange. These findings are discussed in the context of the emerging macrophysiological metabolic theory of ecology.

International exchange of radiological information in emergency conditions

International Nuclear Information System (INIS)

De Cort, M.; De Vries, G.; Breitenbach, L.; Fraser, G.; Vade, S.

1998-01-01

Description of the current system, experience gained, and expected future developments is given for the ECURIE system and, in particular, the EURDEP European-wide radiological information exchange system. It is concluded that the existing situation continues to be inhomogeneous. Although EURDEP foresees a common format for data exchange, which has been successfully implemented in 9 European countries, and regular exercises for data have been performed for a few years, important efforts will still have to be made to come to a more homogeneous and consistent European system for radiological information exchange. (P.A.)

Fluid Analysis and Improved Structure of an ATEG Heat Exchanger Based on Computational Fluid Dynamics

Science.gov (United States)

Tang, Z. B.; Deng, Y. D.; Su, C. Q.; Yuan, X. H.

2015-06-01

In this study, a numerical model has been employed to analyze the internal flow field distribution in a heat exchanger applied for an automotive thermoelectric generator based on computational fluid dynamics. The model simulates the influence of factors relevant to the heat exchanger, including the automotive waste heat mass flow velocity, temperature, internal fins, and back pressure. The result is in good agreement with experimental test data. Sensitivity analysis of the inlet parameters shows that increase of the exhaust velocity, compared with the inlet temperature, makes little contribution (0.1 versus 0.19) to the heat transfer but results in a detrimental back pressure increase (0.69 versus 0.21). A configuration equipped with internal fins is proved to offer better thermal performance compared with that without fins. Finally, based on an attempt to improve the internal flow field, a more rational structure is obtained, offering a more homogeneous temperature distribution, higher average heat transfer coefficient, and lower back pressure.

Protein hydrogen exchange measured at single-residue resolution by electron transfer dissociation mass spectrometry

DEFF Research Database (Denmark)

Rand, Kasper D; Zehl, Martin; Jensen, Ole Nørregaard

2009-01-01

Because of unparalleled sensitivity and tolerance to protein size, mass spectrometry (MS) has become a popular method for measuring the solution hydrogen (1H/2H) exchange (HX) of biologically relevant protein states. While incorporated deuterium can be localized to different regions by pepsin....... The deuterium labeling pattern of beta2-microglobulin is retained in the gaseous fragment ions by employing mild declustering conditions for electrospray ionization. A recently developed model peptide is used to arrive at such ion source declustering conditions that prevent the occurrence of intramolecular gas...

Simultaneous heat and mass transfer to air from a compact heat exchanger with water spray precooling and surface deluge cooling

International Nuclear Information System (INIS)

Zhang, Feini; Bock, Jessica; Jacobi, Anthony M.; Wu, Hailing

2014-01-01

Various methods are available to enhance heat exchanger performance with evaporative cooling. In this study, evaporative mist precooling, deluge cooling, and combined cooling schemes are examined experimentally and compared to model predictions. A flexible model of a compact, finned-tube heat exchanger with a wetted surface is developed by applying the governing conservation and rate equations and invoking the heat and mass transfer analogy. The model is applicable for dry, partially wet, or fully wet surface conditions and capable of predicting local heat/mass transfer, wetness condition, and pressure drop of the heat exchanger. Experimental data are obtained from wind tunnel experiments using a louver-fin flat-tube heat exchanger with single-phase tube-side flow. Total capacity, pressure drop, and water drainage behavior under various water usage rates and air face velocities are analyzed and compared to data for dry-surface conditions. A heat exchanger partitioning method for evaporative cooling is introduced to study partially wet surface conditions, as part of a consistent and general method for interpreting wet-surface performance data. The heat exchanger is partitioned into dry and wet portions by introducing a wet surface factor. For the wet part, the enthalpy potential method is used to determine the air-side sensible heat transfer coefficient. Thermal and hydraulic performance is compared to empirical correlations. Total capacity predictions from the model agree with the experimental results with an average deviation of 12.6%. The model is also exercised for four water augmentation schemes; results support operating under a combined mist precooling and deluge cooling scheme. -- Highlights: • A new spray-cooled heat exchanger model is presented and is validated with data. • Heat duty is shown to be asymptotic with spray flow rate. • Meaningful heat transfer coefficients for partially wet conditions are obtained. • Colburn j wet is lower than j dry

Evaluating Academic Programs Abroad: The CIEE Project. CIEE Occasional Papers on International Educational Exchange No. 21.

Science.gov (United States)

Abrams, Irwin; Heller, Francis H.

The evaluation of overseas educational programs for U.S. students by the Council on International Educational Exchange (CIEE) is discussed. The history of the CIEE is reviewed from its beginnings in 1947 when its members were national programming agencies concerned with making travel arrangements for summer programs. As the CIEE grew in…

THE ROLE OF INTERNATIONAL EXCHANGE PROGRAMS IN DESIGN EDUCATION: A CASE STUDY OF AN ARCHITECTURAL DESIGN COURSE IN JAPAN

Directory of Open Access Journals (Sweden)

Murat Dundar

2010-07-01

Full Text Available The purpose of this paper is to discuss role of international exchange programs in design education based on experiences and outputs of the summer school course ICSA (Inter-Cultural Study of Architecture held in Japan with the participation of Japanese and Turkish students for 50 days under the collaboration of Mukogawa Women’s University (MWU, Japan and Bahcesehir University (BSU, Turkey. After the introduction, chapter One will compare educational methods used in architectural design courses. Chapter Two will mainly provide general observations of ICSA in Japan summer school course. In chapter Three, contributions of international exchange programs to design education will be discussed in terms of two different approaches. Finally, chapter Four will outline the main arguments discussed in this paper.

[International legal aspects of responsibility of states and international organizations for the spread of epidemics, pandemics and mass disease].

Science.gov (United States)

Kholikov, I V; Sazonova, K L

2015-08-01

The present article deals with international legal issues that arise in case when various mass diseases go beyond any national jurisdiction. The emphasis is made on the problem of international responsibility, which different actors have to bear in such cases. The authors also examine the implementation of responsibility mechanism, including the indentication of the relevant international court, authorized to establish such liability and identify the specific forms of its realization.

FY 2000 report on the promotion projects by Research Institute of Innovative Technology for the Earth. Projects for international research exchanges and international seminars; 2000 nendo chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo chosa hokokusho. Kokusai kenkyu koryu jigyo / kokusai seminar kaisai jigyo

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

Described herein are the results of the international research exchange projects promoted by Research Institute of Innovative Technology for the Earth (RITE) in FY 2000. The international research exchanges are important for creation of new research areas and technological systems for solving the global environmental problems. In order to promote these activities, RITE invites and dispatches researchers to international conferences and symposiums, promotes research exchanges with major foreign research institutes and academic organizations, and invites and dispatches researchers for medium to long periods. These projects promote exchanges of the latest researches with various institutes, both domestic and foreign, and confirm that the research and development projects now RITE is promoting are closely related to those promoted by various organizations. In the FY 2000, RITE invites 5 foreign researchers for joint researches, and invites 3 foreign researchers to international conferences. RITE also dispatches 3 Japanese researchers to American and European universities, and 12 Japanese researchers to international conferences and the like, to effectively promote the domestic researches and grasp development tendencies at institutes of various countries. RITE holds 5 international seminars for exchanging and discussing broad topics over advanced researches related to global environmental technologies by researchers, both domestic and foreign. (NEDO)

The study on water ingress mass in the steam generator heat-exchange tube rupture accident of modular high temperature gas-cooled reactor

International Nuclear Information System (INIS)

Wang Yan; Shi Lei; Li Fu; Zheng Yanhua

2012-01-01

The steam generator heat-exchange tube rupture (SGTR) accident is an important and particular accident which will result in water ingress to the primary loop of reactor. Water ingress will result in chemical reaction of graphite fuel and structure with water, which may cause overpressure due to generation of explosive gaseous in large quantity. The study on the water ingress accident is significant for the verification of the inherent characteristics of high temperature gas-cooled reactor. The previous research shows that the amount of water ingress mass is the dominant key factor on the severity of the accident consequence. The 200 MWe high temperature gas-cooled reactor (HTR-PM), which is the first modular pebble-bed high temperature gas-cooled reactor in China designed by the Institute of Nuclear and New Energy Technology of Tsinghua University, is selected to be analyzed in this paper. The different DBA accident scenarios of double-ended break of single heat-exchange tube are simulated respectively by the thermal-hydraulic analysis code RETRAN-02. The results show the water ingress mass through the broken heat-exchange tube is related to the break location. The amount of water ingress mass is affected obviously by the capacity of the emptier system. With the balance of safety and economical efficiency, the amount of water ingress mass from the secondary side of steam generator into the primary coolant loop will be reduced by increasing properly the diameter of the draining lines. (authors)

Australian Universities' Strategic Goals of Student Exchange and Participation Rates in Outbound Exchange Programmes

Science.gov (United States)

Daly, Amanda; Barker, Michelle

2010-01-01

International student exchange programmes are acknowledged as one aspect of a broader suite of internationalisation strategies aimed at enhancing students' intercultural understanding and competence. The decision to participate in an exchange programme is dependent on both individual and contextual factors such as student exchange policies and…

Promoting medical competencies through international exchange programs: benefits on communication and effective doctor-patient relationships.

Science.gov (United States)

Jacobs, Fabian; Stegmann, Karsten; Siebeck, Matthias

2014-03-04

Universities are increasingly organizing international exchange programs to meet the requirements of growing globalisation in the field of health care. Analyses based on the programs' fundamental theoretical background are needed to confirm the learning value for participants. This study investigated the extent of sociocultural learning in an exchange program and how sociocultural learning affects the acquisition of domain-specific competencies. Sociocultural learning theories were applied to study the learning effect for German medical students from the LMU Munich, Munich, Germany, of participation in the medical exchange program with Jimma University, Jimma, Ethiopia. First, we performed a qualitative study consisting of interviews with five of the first program participants. The results were used to develop a questionnaire for the subsequent, quantitative study, in which 29 program participants and 23 matched controls performed self-assessments of competencies as defined in the Tuning Project for Health Professionals. The two interrelated studies were combined to answer three different research questions. The participants rated their competence significantly higher than the control group in the fields of doctor-patient relationships and communication in a medical context. Participant responses in the two interrelated studies supported the link between the findings and the suggested theoretical background. Overall, we found that the exchange program affected the areas of doctor-patient relationships and effective communication in a medical context. Vygotsky's sociocultural learning theory contributed to explaining the learning mechanisms of the exchange program.

Thermal performance analysis of heat exchanger for closed wet cooling tower using heat and mass transfer analogy

International Nuclear Information System (INIS)

Yoo, Seong Yeon; Han, Kyu Hyun; Kim, Jin Hyuck

2010-01-01

In closed wet cooling towers, the heat transfer between the air and external tube surfaces can be composed of the sensible heat transfer and the latent heat transfer. The heat transfer coefficient can be obtained from the equation for external heat transfer of tube banks. According to experimental data, the mass transfer coefficient was affected by the air velocity and spray water flow rate. This study provides the correlation equation for mass transfer coefficient based on the analogy of the heat and mass transfer and the experimental data. The results from this correlation equation showed fairly good agreement with experimental data. The cooling capacity and thermal efficiency of the closed wet cooling tower were calculated from the correlation equation to analyze the performance of heat exchanger for the tower

Development to term of sheep embryos reconstructed after inner cell mass/trophoblast exchange.

Science.gov (United States)

Loi, Pasqualino; Galli, Cesare; Lazzari, Giovanna; Matsukawa, Kazutsugu; Fulka, Josef; Goeritz, Frank; Hildebrandt, Thomas B

2018-04-13

Here we report in vitro and term development of sheep embryos after the inner cell mass (ICM) from one set of sheep blastocysts were injected into the trophoblast vesicles of another set. We also observed successful in vitro development of chimeric blastocysts made from sheep trophoblast vesicles injected with bovine ICM. First, we dissected ICMs from 35 sheep blastocysts using a stainless steel microblade and injected them into 29 re-expanded sheep trophoblastic vesicles. Of the 25 successfully micromanipulated trophoblastic vesicles, 15 (51.7%) re-expanded normally and showed proper ICM integration. The seven most well reconstructed embryos were transferred for development to term. Three ewes receiving manipulated blastocysts were pregnant at day 45 (42.8%), and all delivered normal offspring (singletons, two females and one male, average weight: 3.54 ± 0.358 kg). Next, we monitored in vitro development of sheep trophoblasts injected with bovine ICMs. Of 17 injected trophoblastic vesicles, 10 (58.8%) re-expanded after 4 h in culture, and four (40%) exhibited integrated bovine ICM. Our results indicate that ICM/trophoblast exchange is feasible, allowing full term development with satisfactory lambing rate. Therefore, ICM exchange is a promising approach for endangered species conservation.

An algorithm for mass matrix calculation of internally constrained molecular geometries

International Nuclear Information System (INIS)

Aryanpour, Masoud; Dhanda, Abhishek; Pitsch, Heinz

2008-01-01

Dynamic models for molecular systems require the determination of corresponding mass matrix. For constrained geometries, these computations are often not trivial but need special considerations. Here, assembling the mass matrix of internally constrained molecular structures is formulated as an optimization problem. Analytical expressions are derived for the solution of the different possible cases depending on the rank of the constraint matrix. Geometrical interpretations are further used to enhance the solution concept. As an application, we evaluate the mass matrix for a constrained molecule undergoing an electron-transfer reaction. The preexponential factor for this reaction is computed based on the harmonic model

An algorithm for mass matrix calculation of internally constrained molecular geometries.

Science.gov (United States)

Aryanpour, Masoud; Dhanda, Abhishek; Pitsch, Heinz

2008-01-28

Dynamic models for molecular systems require the determination of corresponding mass matrix. For constrained geometries, these computations are often not trivial but need special considerations. Here, assembling the mass matrix of internally constrained molecular structures is formulated as an optimization problem. Analytical expressions are derived for the solution of the different possible cases depending on the rank of the constraint matrix. Geometrical interpretations are further used to enhance the solution concept. As an application, we evaluate the mass matrix for a constrained molecule undergoing an electron-transfer reaction. The preexponential factor for this reaction is computed based on the harmonic model.

Analysis of transient and hysteresis behavior of cross-flow heat exchangers under variable fluid mass flow rate for data center cooling applications

International Nuclear Information System (INIS)

Gao, Tianyi; Murray, Bruce; Sammakia, Bahgat

2015-01-01

Effective thermal management of data centers is an important aspect of reducing the energy required for the reliable operation of data processing and communications equipment. Liquid and hybrid (air/liquid) cooling approaches are becoming more widely used in today's large and complex data center facilities. Examples of these approaches include rear door heat exchangers, in-row and overhead coolers and direct liquid cooled servers. Heat exchangers are primary components of liquid and hybrid cooling systems, and the effectiveness of a heat exchanger strongly influences the thermal performance of a cooling system. Characterizing and modeling the dynamic behavior of heat exchangers is important for the design of cooling systems, especially for control strategies to improve energy efficiency. In this study, a dynamic thermal model is solved numerically in order to predict the transient response of an unmixed–unmixed crossflow heat exchanger, of the type that is widely used in data center cooling equipment. The transient response to step and ramp changes in the mass flow rate of both the hot and cold fluid is investigated. Five model parameters are varied over specific ranges to characterize the transient performance. The parameter range investigated is based on available heat exchanger data. The thermal response to the magnitude, time period and initial and final conditions of the transient input functions is studied in detail. Also, the hysteresis associated with the fluid mass flow rate variation is investigated. The modeling results and performance data are used to analyze specific dynamic performance of heat exchangers used in practical data center cooling applications. - Highlights: • The transient performance of a crossflow heat exchanger was modeled and studied. • This study provides design information for data center thermal management. • The time constant metric was used to study the impacts of many variable inputs. • The hysteresis behavior

Proceedings of the twenty ninth ISMAS international symposium on mass spectrometry

International Nuclear Information System (INIS)

Aggarwal, Suresh K.; Pranaw Kumar; Jaison, P.G.; Sarkar, Arnab; Telmore, Vijay M.

2015-02-01

Mass spectrometry is a truly multi-disciplinary science and has emerged as an indispensable analytical tool due to its high sensitivity, specificity and universality. It is playing a key role in variety of scientific disciplines of chemistry, physics, biology, archaeology, material science etc. Progress in the field of mass spectrometry in the last two decades has led to the advent of new ion sources, improvements in existing mass analyzers and introduction of hybrid mass analyzers. As the technique continues to advance, many new applications have emerged particularly in health sciences and for forensic applications. The current world scenario demands determination at single atom and single molecule with high specificity. The vendors in the international mass spectrometric instrumentation market are guided by these requirements as well as the inputs from mass spectrometrists around the world engaged in new developments. Papers relevant to INIS are indexed separately

Achievement of the charge exchange work diminishing of an internal combustion engine in part load

Directory of Open Access Journals (Sweden)

Stefan POSTRZEDNIK

2012-01-01

Full Text Available Internal combustion engines, used for driving of different cars, occurs not only at full load, but mostly at the part load. The relative load exchange work at the full (nominal engine load is significantly low. At the part load of the IC engine its energy efficiency ηe is significantly lower than in the optimal (nominal field range of the performance parameters. One of the numerous reasons of this effect is regular growing of the relative load exchange work of the IC engine. It is directly connected with the quantitative regulation method commonly used in the IC engines. From the thermodynamic point of view - the main reason of this effect is the throttling process (causing exergy losses occurring in the inlet and outlet channels. The known proposals for solving of this problem are based on applying of the fully electronic control of the motion of inlet, outlet valves and new reference cycles.The idea presented in the paper leads to diminishing the charge exchange work of the IC engines. The problem can be solved using presented in the paper a new concept of the reference cycle (called as eco-cycle of IC engine. The work of the engine basing on the eco-cycle occurs in two 3-stroke stages; the fresh air is delivered only once for both stages, but in range of each stage a new portion of fuel is burned. Normally the charge exchange occurs once during each engine cycle realized. Elaborated proposition bases on the elimination of chosen charge exchange processes and through this the dropping of the charge exchange work can be achieved.

Detente: A Role for U.S.-Soviet Exchanges?

Science.gov (United States)

Herman, Paul F., Jr.

The contribution of international exchanges (e.g., cultural activities, tourism, student exchange) to detente enhancement is assessed. International exchanges have a capacity for engendering trust and for providing cultural, political, and economic benefit, two characteristics of policy acts which tend to enhance detente. A comparison of four very…

75 FR 57385 - Internal Control Over Financial Reporting in Exchange Act Periodic Reports of Non-Accelerated Filers

Science.gov (United States)

2010-09-21

... attestation report of its registered public accounting firm on internal control over financial reporting in... definition of either an ``accelerated filer'' or a ``large accelerated filer'' under Exchange Act Rule 12b-2..., for both definitions, the issuer needs to have been subject to reporting requirements for at least...

International trade and exchange rate volatility

NARCIS (Netherlands)

J.M.A. Viaene (Jean-Marie); C.G. de Vries (Casper)

1992-01-01

textabstractFor currencies with well developed forward markets several papers have investigated the conjectured negative relationship between trade and short term exchange rate volatility, without being very successful. A theoretical explanation for the empirical anomalies is provided by solving

Charge symmetry breaking via Δ I = 1 group theory or by the u-d quark mass difference and direct photon exchange

International Nuclear Information System (INIS)

Coon, S.A.; Scadron, M.D.

2000-01-01

Charge symmetry breaking (CSB) in the strong N N interaction is believed to have its origins at the quark level. However, the meson-exchange potentials which successfully describe the empirical CSB utilize instead values of the Δ I = 1 π η and ρ ω mixing obtained with the aid of group theory from a hadronic tadpole Hamiltonian introduced by Coleman and Glashow to describe electromagnetic mass splitting in hadronic isospin multiplets. We review i) the CSB N N potentials so constructed and their nuclear charge asymmetry effects, i i) the universal scale of the Coleman-Glashow tadpole, and i i i) the quark loop evaluation of both meson mass differences and meson mixing. The latter quark loop calculations, which use chiral symmetry to evaluate the integrals, demonstrate clearly that the u-d constituent quark mass difference, long suspected as the origin of CSB, does quantitatively yield the universal Coleman-Glashow tadpole scale which underlies the successful meson-exchange description of CSB in nuclear physics. (Author) 38 refs., 3 figs

U/Th dating by SHRIMP RG ion-microprobe mass spectrometry using single ion-exchange beads

Science.gov (United States)

Bischoff, J.L.; Wooden, J.; Murphy, F.; Williams, Ross W.

2005-01-01

We present a new analytical method for U-series isotopes using the SHRIMP RG (Sensitive High mass Resolution Ion MicroProbe) mass spectrometer that utilizes the preconcentration of the U-series isotopes from a sample onto a single ion-exchange bead. Ion-microprobe mass spectrometry is capable of producing Th ionization efficiencies in excess of 2%. Analytical precision is typically better than alpha spectroscopy, but not as good as thermal ionization mass spectroscopy (TIMS) and inductively coupled plasma multicollector mass spectrometry (ICP-MS). Like TIMS and ICP-MS the method allows analysis of small samples sizes, but also adds the advantage of rapidity of analysis. A major advantage of ion-microprobe analysis is that U and Th isotopes are analyzed in the same bead, simplifying the process of chemical separation. Analytical time on the instrument is ???60 min per sample, and a single instrument-loading can accommodate 15-20 samples to be analyzed in a 24-h day. An additional advantage is that the method allows multiple reanalyses of the same bead and that samples can be archived for reanalysis at a later time. Because the ion beam excavates a pit only a few ??m deep, the mount can later be repolished and reanalyzed numerous times. The method described of preconcentrating a low concentration sample onto a small conductive substrate to allow ion-microprobe mass spectrometry is potentially applicable to many other systems. Copyright ?? 2005 Elsevier Ltd.

Superconducting spin switch with infinite magnetoresistance induced by an internal exchange field.

Science.gov (United States)

Li, Bin; Roschewsky, Niklas; Assaf, Badih A; Eich, Marius; Epstein-Martin, Marguerite; Heiman, Don; Münzenberg, Markus; Moodera, Jagadeesh S

2013-03-01

A theoretical prediction by de Gennes suggests that the resistance in a FI/S/FI (where FI is a ferromagnetic insulator, and S is a superconductor) structure will depend on the magnetization direction of the two FI layers. We report a magnetotransport measurement in a EuS/Al/EuS structure, showing that an infinite magnetoresistance can be produced by tuning the internal exchange field at the FI/S interface. This proximity effect at the interface can be suppressed by an Al(2)O(3) barrier as thin as 0.3 nm, showing the extreme confinement of the interaction to the interface giving rise to the demonstrated phenomena.

Response timescales for martian ice masses and implications for ice flow on Mars

DEFF Research Database (Denmark)

Koutnik, Michelle Rebecca; Waddington, E.D.; Winebrener, D.P.

2013-01-01

a predictable shape, which is a function of ice temperature, ice rheology, and surface mass-exchange rate. In addition, the time for surface-shape adjustment is shorter than the characteristic time for significant deformation or displacement of internal layers within a flowing ice mass; as a result, surface......On Earth and on Mars, ice masses experience changes in precipitation, temperature, and radiation. In a new climate state, flowing ice masses will adjust in length and in thickness, and this response toward a new steady state has a characteristic timescale. However, a flowing ice mass has...... topography is more diagnostic of flow than are internal-layer shapes. Because the shape of Gemina Lingula, North Polar Layered Deposits indicates that it flowed at some time in the past, we use its current topography to infer characteristics of those past ice conditions, or past climate conditions, in which...

Probing the Conformational and Functional Consequences of Disulfide Bond Engineering in Growth Hormone by Hydrogen-Deuterium Exchange Mass Spectrometry Coupled to Electron Transfer Dissociation

DEFF Research Database (Denmark)

Seger, Signe T; Breinholt, Jens; Faber, Johan H

2015-01-01

Human growth hormone (hGH), and its receptor interaction, is essential for cell growth. To stabilize a flexible loop between helices 3 and 4, while retaining affinity for the hGH receptor, we have engineered a new hGH variant (Q84C/Y143C). Here, we employ hydrogen-deuterium exchange mass spectrom......Human growth hormone (hGH), and its receptor interaction, is essential for cell growth. To stabilize a flexible loop between helices 3 and 4, while retaining affinity for the hGH receptor, we have engineered a new hGH variant (Q84C/Y143C). Here, we employ hydrogen-deuterium exchange mass...

Isotopic enrichment of 15N by ionic exchange chromatography

International Nuclear Information System (INIS)

Trivelin, P.C.O.

1979-01-01

The present paper presents some studies on production of 15 N-enriched ammonium sulphate with 5% atoms by ionic exchange chromatography method. Two systems are described of columns of resin, where experiments were conducted by eluition of NH 4 + bands with sodium hydroxide solution. Analyses were made of the cost of production of 15 N-enriched ammonium sulphate 5% atoms and, based on the experiments developed, a cost was obtained which was compatible with the international price of the product. The isotopic analyses of nitrogen were made by mass spectrometry. (Author) [pt

I was expecting her to be a fanatic Catholic, but she was not. How International Exchange Programmes Reduce Prejudice

Czech Academy of Sciences Publication Activity Database

Leix, Alicja

2013-01-01

Roč. 31, č. 1 (2013), s. 205-216 ISSN 1732-6729 R&D Projects: GA ČR GA13-25656S Keywords : international exchange programmes * Lifelong Learning Programmes * Erasmus generation Subject RIV: AN - Psychology Impact factor: 0.149, year: 2012

Corporate Characteristics and Internal Control Information Disclosure- Evidence from Annual Reports in 2009 of Listed Companies in Shenzhen Stock Exchange

Science.gov (United States)

Xiaowen, Song

Under the research framework of internal control disclosure and combined the current economic situation, the paper empirically analyzes the relationship between corporate characteristics and internal control information disclosure. The paper selects 647 A share companies listed in Shenzhen Stock Exchanges in 2009 as a sample. The results show: (1) the companies with excellent performance and high liquidity tend to disclose more internal control information; (2) the companies with the high leverage and also issued B shares are not willing to disclosure internal control information; (3) the companies sizes and companies which have hired Four-big accounting firms have no significant effects on internal control disclosure.

A distributed control algorithm for internal flow management in a multi-zone climate unit

NARCIS (Netherlands)

Persis, C. De; Jessen, J.J.; Izadi-Zamanabadi, R.; Schiøler, H.

2008-01-01

We examine a distributed control problem for internal flow management in a multi-zone climate unit. The problem consists of guaranteeing prescribed indoor climate conditions in a cascade connection of an arbitrarily large number of communicating zones, in which air masses are exchanged to redirect

Determination of external and internal mass transfer limitation in nitrifying microbial aggregates.

Science.gov (United States)

Wilén, Britt-Marie; Gapes, Daniel; Keller, Jürg

2004-05-20

In this article we present a study of the effects of external and internal mass transfer limitation of oxygen in a nitrifying system. The oxygen uptake rates (OUR) were measured on both a macro-scale with a respirometric reactor using off-gas analysis (Titrimetric and Off-Gas Analysis (TOGA) sensor) and on a micro-scale with microsensors. These two methods provide independent, accurate measurements of the reaction rates and concentration profiles around and in the granules. The TOGA sensor and microsensor measurements showed a significant external mass transfer effect at low dissolved oxygen (DO) concentrations in the bulk liquid while it was insignificant at higher DO concentrations. The oxygen distribution with anaerobic or anoxic conditions in the center clearly shows major mass transfer limitation in the aggregate interior. The large drop in DO concentration of 22-80% between the bulk liquid and aggregate surface demonstrates that the external mass transfer resistance is also highly important. The maximum OUR even for floccular biomass was only attained at much higher DO concentrations (approximately 8 mg/L) than typically used in such systems. For granules, the DO required for maximal activity was estimated to be >20 mg/L, clearly indicating the effects of the major external and internal mass transfer limitations on the overall biomass activity. Smaller aggregates had a larger volumetric OUR indicating that the granules may have a lower activity in the interior part of the aggregate. Copyright 2004 Wiley Periodicals, Inc.

Quantitation of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry using (18)O-labeled internal standards

DEFF Research Database (Denmark)

Mirgorodskaya, O A; Kozmin, Y P; Titov, M I

2000-01-01

A method for quantitating proteins and peptides in the low picomole and sub-picomole range has been developed using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) with internal (18)O-labeled standards. A simple procedure is proposed to produce such internal standards for...... inhibitor, were quantified by MALDI-time-of-flight (TOF) mass spectrometry.......A method for quantitating proteins and peptides in the low picomole and sub-picomole range has been developed using matrix-assisted laser desorption/ionization mass spectrometry (MALDI-MS) with internal (18)O-labeled standards. A simple procedure is proposed to produce such internal standards...

Choice of exchange rate regimes for African countries: Fixed or Flexible Exchange rate regimes?

OpenAIRE

Simwaka, Kisu

2010-01-01

The choice of an appropriate exchange rate regime has been a subject of ongoing debate in international economics. The majority of African countries are small open economies and thus where the choice of the exchange rate regime is an important policy issue. Aside from factors such as interest rates and inflation, the exchange rate is one of the most important determinants of a country’s relative level of economic health. For this reason, exchange rates are among the most watched analyzed and ...

Gas-phase fragmentation of peptides to increase the spatial resolution of the Hydrogen Exchange Mass Spectrometry experiment

DEFF Research Database (Denmark)

Jensen, Pernille Foged; Rand, Kasper Dyrberg

2016-01-01

are produced after precursor ion selection and thus do not add complexity to the LC-MS analysis. The key to obtaining optimal spatial resolution in a hydrogen exchange mass spectrometry (HX-MS) experiment is the fragmentation efficiency. This chapter discusses common fragmentation techniques like collision....../D scrambling, thus making them suitable for HX applications. By combining the classic bottom-up HX-MS workflow with gas-phase fragmentation by ETD, detailed information on protein HX can be obtained....

Effective Exchange Rate Classifications and Growth

OpenAIRE

Justin M. Dubas; Byung-Joo Lee; Nelson C. Mark

2005-01-01

We propose an econometric procedure for obtaining de facto exchange rate regime classifications which we apply to study the relationship between exchange rate regimes and economic growth. Our classification method models the de jure regimes as outcomes of a multinomial logit choice problem conditional on the volatility of a country's effective exchange rate, a bilateral exchange rate and international reserves. An `effective' de facto exchange rate regime classification is then obtained by as...

A dynamic model for helium core heat exchangers

International Nuclear Information System (INIS)

Schiesser, W.E.; Shih, H.J.; Hartozog, D.G.; Herron, D.M.; Nahmias, D.; Stuber, W.G.; Hindmarsh, A.C.

1990-04-01

To meet the helium (He) requirements of the superconducting supercollider (SSC), the cryogenic plants must be able to respond to time-varying loads. Thus the design and simulation of the cryogenic plants requires dynamic models of their principal components, and in particular, the core heat exchangers. In this paper, we detail the derivation and computer implementation of a model for core heat exchangers consisting of three partial differential equations (PDES) for each fluid stream (the continuity, energy and momentum balances for the He), and one PDE for each parting sheet (the energy balance for the parting sheet metal); the PDEs have time and axial position along the exchanger as independent variables. The computer code can accommodate any number of fluid streams and parting sheets in an adiabatic group. Features of the code include: rigorous or approximate thermodynamic properties for He, upwind and downwind approximation of the PDE spatial derivatives, and sparse matrix time integration. The outputs from the code include the time-dependent axial profiles of the fluid He mass flux, density, pressure, temperature, internal energy and enthalpy. The code is written in transportable Fortran 77, and can therefore be executed on essentially any computer

A dynamic model for helium core heat exchangers

International Nuclear Information System (INIS)

Schiesser, W.E.; Shih, H.J.; Hartzog, D.G.; Herron, D.M.; Nahmias, D.; Stuber, W.G.; Hindmarsh, A.C.

1990-01-01

To meet the helium (He) requirements of the superconducting supercollider (SSC), the cryogenic plants must be able to respond to time-varying loads. Thus the design and simulation of the cryogenic plants requires dynamic models of their principal components, and in particular, the core heat exchangers. In this paper, we detail the derivation and computer implementation of a model for core heat exchangers consisting of three partial differential equations (PDEs) for each fluid stream (the continuity, energy and momentum balances for the He), and one PDE for each parting sheet (the energy balance for the parting sheet metal); the PDEs have time and axial position along the exchanger as independent variables. The computer code can accommodate any number of fluid streams and parting sheets in an adiabatic group. Features of the code include: rigorous or approximate thermodynamic properties for He, upwind and downwind approximation of the PDE spatial derivatives, and sparse matrix time integration. The outputs from the code include the time-dependent axial profiles of the fluid He mass flux, density, pressure, temperature, internal energy and enthalpy. The code is written in transportable Fortran 77, and can therefore be executed on essentially any computer. 10 refs., 10 figs

Closure of mass exchange under use of a vegetable conveyer cultivated on a neutral and soil-like substrates as applied to BLSS

Science.gov (United States)

Velitchko, Vladimir; Tikhomirov, Alexander; Ushakova, Sofya

To increase a closure level of mass exchange processes in bioregenerative life support systems (BLSS) including a human a technology of plants cultivation on a soil-like substrate (SLS) consisting in a gradual decomposition of inedible plants biomass under its addition in the SLS was developed at the Institute of Biophysics SB RAS (Russia). In the given work the effect of periodical introduction of inedible plant biomass in the SLS on plants photosynthetic productivity and on the closure of mass exchange has been analyzed. Thereupon CO2 gas exchange and the certain vegetables' productivity under their cultivation in a conveyor regime on the SLS and on a neutral substrate with reference to the closure of mass exchange processes in BLSS have been studied in this work. The vegetables Raphanus sativus L., Brassica caulorapa L. Daucus carota L. and Beta vulgaris L. being prospective plantsrepresentatives of the BLSS phototrophic unit were taken as the research objects. The SLS was taken as an experiment substrate and an expanded clay aggregate as the control. The changeable Knop solution was used for the control, and an irrigation solution with the SLS extract was used for the experiment. Rapidity dynamics of CO2 consumption showed sharp distinctions of the ‘plants-SLS' system from the ‘plantsexpanded clay aggregate' system connected with the oxidation processes coursing in the SLS. The intensity of CO2 evolution from the SLS on average was 70% of the total plants conveyor's respiration. Thus a balance between the system's respiration and photosynthesis was often determined by the processes coursing in the SLS. Here the sharp CO2 evolution was recorded after introduction of the plants inedible biomass in the SLS. That peak was gradually coming down during 10-14 days after the beginning of every cycle of plants cultivation that was connected with intensification of plants photosynthesis and drop of decomposition intensity of the biomass introduced. Comparative

International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Overseas workshop; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

The international exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998, the 'Overseas workshop' has performed exchange in technologies with Australian coal mine engineers. The project refers to the Australian technological levels and needs in coal production, safety control and environment, as well as transfer of the Japanese coal mine technologies. This report summarizes the result of a survey on the engineer exchange project in the coal mine technology area and the possibility of joint researches. The 'overseas workshop' was held in November 1998 for two days in Brisbane City in QLD Province as the 'Japan-Australia coal technology workshop'. The 'Japan-Australia coal technology workshop' gave lectures in five sessions (the basic lecture, Japan-Australia high-speed excavation project, coal mine gas control project, exploration and resources, and development and experience of Japan). It also discussed two themes (mine safety management and rules, and greenhouse effect gases and coal mining). Two coal mines were visited thereafter to deepen the exchange with the Australian coal mine engineers. (NEDO)

Inclusion of human mineralized exometabolites and fish wastes as a source of higher plant mineral nutrition in BTLSS mass exchange

Science.gov (United States)

Tikhomirova, Natalia; Tikhomirov, Alexander A.; Ushakova, Sofya; Anischenko, Olesya; Trifonov, Sergey V.

Human exometabolites inclusion into an intrasystem mass exchange will allow increasing of a closure level of a biological-technical life support system (BTLSS). Previously at the IBP SB RAS it was shown that human mineralized exometabolites could be incorporated in the BTLSS mass exchange as a mineral nutrition source for higher plants. However, it is not known how that combined use of human mineralized exometabolites and fish wastes in the capacity of nutrient medium, being a part of the BTLSS consumer wastes, will affect the plant productivity. Several wheat vegetations were grown in an uneven-aged conveyor on a neutral substrate. A mixture of human mineralized exometabolites and fish wastes was used as a nutrient solution in the experiment treatment and human mineralized exometabolites were used in the control. Consequently, a high wheat yield in the experiment treatment practically equal to the control yield was obtained. Thus, mineralized fish wastes can be an additional source of macro-and micronutrients for plants, and use of such wastes for the plant mineral nutrition allows increasing of BTLSS closure level.

Mass and Heat Transfer Analysis of Membrane Humidifier with a Simple Lumped Mass Model

International Nuclear Information System (INIS)

Lee, Young Duk; Bae, Ho June; Ahn, Kook Young; Yu, Sang Seok; Hwang, Joon Young

2009-01-01

The performance of proton exchange membrane fuel cell (PEMFC) is seriously changed by the humidification condition which is intrinsic characteristics of the PEMFC. Typically, the humidification of fuel cell is carried out with internal or external humidifier. A membrane humidifier is applied to the external humidification of residential power generation fuel cell due to its convenience and high performance. In this study, a simple static model is constructed to understand the physical phenomena of the membrane humidifier in terms of geometric parameters and operating parameters. The model utilizes the concept of shell and tube heat exchanger but the model is also able to estimate the mass transport through the membrane. Model is constructed with FORTRAN under Matlab/Simulink □ environment to keep consistency with other components model which we already developed. Results shows that the humidity of wet gas and membrane thickness are critical parameters to improve the performance of the humidifier

Hydrogen exchange

DEFF Research Database (Denmark)

Jensen, Pernille Foged; Rand, Kasper Dyrberg

2016-01-01

Hydrogen exchange (HX) monitored by mass spectrometry (MS) is a powerful analytical method for investigation of protein conformation and dynamics. HX-MS monitors isotopic exchange of hydrogen in protein backbone amides and thus serves as a sensitive method for probing protein conformation...... and dynamics along the entire protein backbone. This chapter describes the exchange of backbone amide hydrogen which is highly quenchable as it is strongly dependent on the pH and temperature. The HX rates of backbone amide hydrogen are sensitive and very useful probes of protein conformation......, as they are distributed along the polypeptide backbone and form the fundamental hydrogen-bonding networks of basic secondary structure. The effect of pressure on HX in unstructured polypeptides (poly-dl-lysine and oxidatively unfolded ribonuclease A) and native folded proteins (lysozyme and ribonuclease A) was evaluated...

Challenges of implementating a doctoral program in an international exchange in Cuba through the lens of Kanter's empowerment theory.

Science.gov (United States)

Scanlan, Judith M; Abdul Hernandéz, C

2014-08-01

The literature in international education focuses primarily on the experiences of western students in developing countries, international students in western universities, the development of an educational program in a developing country, or internationalization of curricula in western universities. There is little in the literature that addresses the challenges students and participating faculty face when implementing a graduate program in a developing country. The purpose of this paper is to describe and analyze the challenges of implementing a doctoral program in an international exchange through the lens of Kanter's theory of empowerment. Recommendations to address these challenges will be made. Copyright © 2014 Elsevier Ltd. All rights reserved.

Application of secondary ions mass spectrometry (SIMS) in studies of internal contamination

International Nuclear Information System (INIS)

Amaral, Ademir; Galle, Pierre; Colas-Linhart, Nicole

2000-01-01

Secondary Ion Mass Spectrometry (SIMS) permits the detection of stable and radioactive nuclides. Based on the ablation of specimens by ion bombardment this mass spectrometry method allows a rapid assessment of trace elements in biological samples. Its resolving mass power provides an efficient analytical method and, in particular, it makes possible accurate isotopic ratio determination. In this work, the application of SIMS has been investigated in studies of internal contamination. In vivo studies were carried out using duodenal tissue sections from rats contaminated with cerium. Tests were performed to localize this element as a result of the contamination. In this report, analytical procedures and the potential of SIMS in biological research are presented and discussed. (author)

Negative ion electrospray ionization mass spectrometry of nucleoside phosphoramidate monoesters: elucidation of novel rearrangement mechanisms by multistage mass spectrometry incorporating in-source deuterium labelling.

Science.gov (United States)

Xu, Peng-Xiang; Hu, An-Fu; Hu, Dan; Gao, Xiang; Zhao, Yu-Fen

2008-10-01

Several O-2',3'-isopropylideneuridine-O-5'-phosphoramidate monoesters were synthesized and analyzed by negative ion electrospray ionization tandem mass spectrometry (ESI-MS(n)). Two kinds of novel rearrangement reactions were observed due to the difference in the amino acid in the nucleoside phosphoramidate monoesters, and possible mechanisms were proposed. One involves a five-membered cyclic transition state. The other is formation of a stable five-membered ring intermediate by Michael addition. Results were confirmed by tandem mass spectrometry and isotopically labeled hydrogen atoms. Furthermore, the internal hydrogen exchange between active hydrogen and methyl acrylate in the heated capillary of the mass spectrometer was found. The characteristic fragmentation behavior in ESI-MS may be used to monitor this kind of compounds in the biological metabolism.

The mass transfer dynamics of gaseous methyl-iodide adsorption by silver-exchanged sodium mordenite

International Nuclear Information System (INIS)

Jubin, R.T.

1994-12-01

The adsorption of methyl iodide onto hydrogen-reduced silver-exchange mordenite was studied. The removal of organic iodides from off-gas streams is an important step in controlling the release of radioactive iodine to the environment during the treatment of radioactive wastes or the processing of some irradiated materials. Nine well accepted mass transfer models were evaluated for their ability to adequately explain the observed CH 3 I uptake behavior onto the Ag-Z. Linear and multidimensional regression techniques were utilized in the estimation of the diffusion constants and other model parameters which then permitted the selection of an appropriate mass transfer model. To date, only bulk loading data exist for the adsorption of CH 3 I onto Ag-Z. Hence this is believed to be the first study to quantify the controlling mass transfer mechanisms of this process. It can be concluded from the analysis of the experimental data obtained by the single-pellet type experiments and for the process conditions used in this study that the overall mass transfer rate associated with the adsorption of CH 3 I onto Ag-Z is affected by both micropore and macropore diffusion. The macropore diffusion rate was significantly faster than the micropore diffusion, resulting in a two-step adsorption behavior which was adequately modeled by a bimodal pore distribution model. The micropore diffusivity was determined to be on the order of 2 x 10 -14 cm 2 /s. The system was also shown to be isothermal under all conditions of this study. Two other conclusions were also obtained. First, the gas film resistance to mass transfer for the 1/16 and 1/8-in.-diam Ag-Z pellets can be ignored under the conditions used in this study. Finally, it was shown that by decreasing the water vapor content of the feed gas, the chemical reaction rate appeared to become the initial rate-limiting factor for the mass transfer. 75 refs

International exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998. Overseas workshop; 1998 nendo gijutsusha koryu jigyo (tanko gijutsu bun'ya) kokusai koryu jigyo. Kaigai workshop

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

The international exchange project for the engineer exchange project (in coal mine technology area) in fiscal 1998, the 'Overseas workshop' has performed exchange in technologies with Australian coal mine engineers. The project refers to the Australian technological levels and needs in coal production, safety control and environment, as well as transfer of the Japanese coal mine technologies. This report summarizes the result of a survey on the engineer exchange project in the coal mine technology area and the possibility of joint researches. The 'overseas workshop' was held in November 1998 for two days in Brisbane City in QLD Province as the 'Japan-Australia coal technology workshop'. The 'Japan-Australia coal technology workshop' gave lectures in five sessions (the basic lecture, Japan-Australia high-speed excavation project, coal mine gas control project, exploration and resources, and development and experience of Japan). It also discussed two themes (mine safety management and rules, and greenhouse effect gases and coal mining). Two coal mines were visited thereafter to deepen the exchange with the Australian coal mine engineers. (NEDO)

Conformational Assessment of Adnectin and Adnectin-Drug Conjugate by Hydrogen/Deuterium Exchange Mass Spectrometry

Science.gov (United States)

Huang, Richard Y.-C.; O'Neil, Steven R.; Lipovšek, Daša; Chen, Guodong

2018-05-01

Higher-order structure (HOS) characterization of therapeutic protein-drug conjugates for comprehensive assessment of conjugation-induced protein conformational changes is an important consideration in the biopharmaceutical industry to ensure proper behavior of protein therapeutics. In this study, conformational dynamics of a small therapeutic protein, adnectin 1, together with its drug conjugate were characterized by hydrogen/deuterium exchange mass spectrometry (HDX-MS) with different spatial resolutions. Top-down HDX allows detailed assessment of the residue-level deuterium content in the payload conjugation region. HDX-MS dataset revealed the ability of peptide-based payload/linker to retain deuterium in HDX experiments. Combined results from intact, top-down, and bottom-up HDX indicated no significant conformational changes of adnectin 1 upon payload conjugation. [Figure not available: see fulltext.

Internal hydraulic control in the Little Belt, Denmark - observations of flow configurations and water mass formation

Science.gov (United States)

Holtegaard Nielsen, Morten; Vang, Torben; Chresten Lund-Hansen, Lars

2017-12-01

Internal hydraulic control, which occurs when stratified water masses are forced through an abrupt constriction, plays an enormous role in nature on both large and regional scales with respect to dynamics, circulation, and water mass formation. Despite a growing literature on this subject surprisingly few direct observations have been made that conclusively show the existence of and the circumstances related to internal hydraulic control in nature. In this study we present observations from the Little Belt, Denmark, one of three narrow straits connecting the Baltic Sea and the North Sea. The observations (comprised primarily of along-strait, detailed transects of salinity and temperature; continuous observations of flow velocity, salinity, and temperature at a permanent station; and numerous vertical profiles of salinity, temperature, fluorescence, and flow velocity in various locations) show that internal hydraulic control is a frequently occurring phenomenon in the Little Belt. The observations, which are limited to south-going flows of approximately two-layered water masses, show that internal hydraulic control may take either of two configurations, i.e. the lower or the upper layer being the active, accelerating one. This is connected to the depth of the pycnocline on the upstream side and the topography, which is both deepening and contracting toward the narrow part of the Little Belt. The existence of two possible flow configurations is known from theoretical and laboratory studies, but we believe that this has never been observed in nature and reported before. The water masses formed by the intense mixing, which is tightly connected with the presence of control, may be found far downstream of the point of control. The observations show that these particular water masses are associated with chlorophyll concentrations that are considerably higher than in adjacent water masses, showing that control has a considerable influence on the primary production and

Dynamical Mass Generation.

Science.gov (United States)

Mendel Horwitz, Roberto Ruben

1982-03-01

In the framework of the Glashow-Weinberg-Salem model without elementary scalar particles, we show that masses for fermions and intermediate vector bosons can be generated dynamically. The mechanism is the formation of fermion-antifermion pseudoscalar bound states of zero total four momentum, which form a condensate in the physical vacuum. The force responsible for the binding is the short distance part of the net Coulomb force due to photon and Z exchange. Fermions and bosons acquire masses through their interaction with this condensate. The neutrinos remain massless because their righthanded components have no interactions. Also the charge -1/3 quarks remain massless because the repulsive force from the Z exchange dominates over the Coulomb force. To correct this, we propose two possible modifications to the theory. One is to cut off the Z exchange at very small distances, so that all fermions except the neutrinos acquire masses, which are then, purely electromagnetic in origin. The other is to introduce an additional gauge boson that couples to all quarks with a pure vector coupling. To make this vector boson unobservable at usual energies, at least two new fermions must couple to it. The vector boson squared masses receive additive contributions from all the fermion squared masses. The photon remains massless and the masses of the Z and W('(+OR -)) bosons are shown to be related through the Weinberg angle in the conventional way. Assuming only three families of fermions, we obtain estimates for the top quark mass.

First results of out-of-pile experiments concerning cooling phenomena of molten layers with internal heat sources

International Nuclear Information System (INIS)

Fieg, G.

1977-01-01

After severe hypothetical reactor accidents, large amounts of molten core material with internal heat generation may appear. It must be guaranteed that these materials can be kept within the containment. To clarify this situation, the knowledge of heat transport from liquid layers with internal heat generation is needed. First experimental results on heat transport from internally heated horizontal fluid layers are presented. The experiments have been performed in a smooth horizontal vessel with the base of 15 x 15 cm 2 . The Joule-heated liquid layer (depth L = 1 cm - 3.5 cm) is enclosed between two isothermal horizontal walls. They are polished fore parts of heat exchangers. The temperatures of the walls were held constant with thermostatically controlled water circulating through the heat exchangers. Horizontal heat fluxes were depressed by appropriate insulation of the side walls. The total heat transport to the upper and lower boundaries has been measured by the mass transport through the heat exchangers and the temperature rise of the cooling water

Foreign Exchange Markets in Russia: Understanding the Reforms

OpenAIRE

Linda S. Goldberg

1993-01-01

This paper analyzes and interprets the changes that took place in Russia's exchange rate system during 1992. The multiple exchange rate regime that existed in Russia prior to July 3, 1992, created strong incentives for exporters to refrain from repatriating foreign exchange earnings, induced both importers and exporters to participate in unofficial markets for foreign exchange, and encouraged international barter transactions. Efforts to manage the exchange rate through heavy foreign exchange...

Isotope anomalies in oxygen isotope exchange equilibrium systems

International Nuclear Information System (INIS)

Kotaka, M.

1997-01-01

The purpose of the present work is to elucidate the isotope anomalies in oxygen isotope exchange equilibrium systems, according to the calculations of the equilibrium constants for oxygen isotopic exchange reactions, and the calculations of the oxygen isotope separation factors between two phases. The equilibrium constants (K65, K67, K68 and K69) of 16 O- 15 O, 16 O 17 O, 16 O- 18 O, and 16 O- 19 O exchange reactions between diatomic oxides were calculated in a wide temperature range on the basis of quantum statistical mechanics. Many equilibrium constants showed the anomalous mass effects, and then had the crossover temperatures and the mass independent fractionation (MIF) temperatures which held K67 = K65, K67 = K68, or K67 = K69, etc. For example, the equilibrium constants for the reactions between OH and the other diatomic oxides (MO) showed the anomalous mass effects, when M was Li, Na, Mg, K, Fe, Al, Ge, Zr, Pt, etc. The 16 O 15 O, 16 O 17 O, 16 O- 18 O, and 16 O- 19 O oxygen isotope separation factors (S65, S67, S68 and S69) between two phases were calculated, when OH and CO were in the first phase, and SiO was in the second phase. Although the oxygen isotopic exchange equilibria in the two phases had no MIF and crossover temperatures, the separation factors showed the anomalous mass effects and had the temperatures. According to what is called the normal mass effects for the equilibrium constant of isotopic exchange reaction, the value of InK68/InK67 is 1.885. Therefore, the value of InS68/InS67 should be 1.885 too. The value calculated, however, widely changed. It can be concluded from the results obtained in the present work that some oxygen isotopic exchange equilibria cause the anomalous mass effects, the anomalous oxygen isotope separation factors, and then isotope anomalies

Thermodynamic optimization of heat exchanger tanks by exergy ...

African Journals Online (AJOL)

The paper introduces heat exchanger tanks, detailing their dominant thermodynamic relations to obtain the exergy analysis relations of heat exchanger tanks. Heat exchanger tank is examined under various laboratory conditions, including the power of heat element inside the tank, mass flow rate of cooling water of tank ...

Characterization of oligosaccharides with capillary high performance anion exchange chromatography hyphenated to pulsed amperometric detection and ion trap mass spectrometry : application to the analysis of human lysosomal disorders

NARCIS (Netherlands)

Bruggink, Cornelis

The development of a capillary ion chromatograph is described together with a matching desalter. This desalter made it possible to use on-line a mass spectrometer. The mass spectrometer enables partly to characterize carbohydrates eluting from the anion exchange column. This separation technology is

MONETARY MODELS AND EXCHANGE RATE DETERMINATION ...

African Journals Online (AJOL)

Power Party [PPP] based on the law of one price asserts that the change in the exchange rate between .... exchange in international economic transactions has made it vitally evident that the management of ... One lesson from this episode is to ...

Investigating the Interaction between the Neonatal Fc Receptor and Monoclonal Antibody Variants by Hydrogen/Deuterium Exchange Mass Spectrometry

DEFF Research Database (Denmark)

Jensen, Pernille Foged; Larraillet, Vincent; Schlothauer, Tilman

2015-01-01

The recycling of immunoglobulins by the neonatal Fc receptor (FcRn) is of crucial importance in the maintenance of antibody levels in plasma and is responsible for the long half-lives of endogenous and recombinant monoclonal antibodies. From a therapeutic point of view there is great interest...... in understanding and modulating the IgG-FcRn interaction to optimize antibody pharmacokinetics and ultimately improve efficacy and safety. Here we studied the interaction between a full-length human IgG1 and human FcRn via hydrogen/deuterium exchange mass spectrometry and targeted electron transfer dissociation...... to map sites perturbed by binding on both partners of the IgG-FcRn complex. Several regions in the antibody Fc region and the FcRn were protected from exchange upon complex formation, in good agreement with previous crystallographic studies of FcRn in complex with the Fc fragment. Interestingly, we found...

Affinity capture of biotinylated proteins at acidic conditions to facilitate hydrogen/deuterium exchange mass spectrometry analysis of multimeric protein complexes

DEFF Research Database (Denmark)

Jensen, Pernille Foged; Jørgensen, Thomas J. D.; Koefoed, Klaus

2013-01-01

Characterization of conformational and dynamic changes associated with protein interactions can be done by hydrogen/deuterium exchange mass spectrometry (HDX-MS) by comparing the deuterium uptake in the bound and unbound state of the proteins. Investigation of local hydrogen/deuterium exchange...... in heteromultimeric protein complexes poses a challenge for the method due to the increased complexity of the mixture of peptides originating from all interaction partners in the complex. Previously, interference of peptides from one interaction partner has been removed by immobilizing the intact protein on beads...... complexes without interference of peptides originating from other interaction partners in the complex. The biotin-streptavidin strategy has been successfully implemented in a model system with two recombinant monoclonal antibodies that target nonoverlapping epitopes on the human epidermal growth factor...

Optimization of Heat Exchangers

International Nuclear Information System (INIS)

Catton, Ivan

2010-01-01

The objective of this research is to develop tools to design and optimize heat exchangers (HE) and compact heat exchangers (CHE) for intermediate loop heat transport systems found in the very high temperature reator (VHTR) and other Generation IV designs by addressing heat transfer surface augmentation and conjugate modeling. To optimize heat exchanger, a fast running model must be created that will allow for multiple designs to be compared quickly. To model a heat exchanger, volume averaging theory, VAT, is used. VAT allows for the conservation of mass, momentum and energy to be solved for point by point in a 3 dimensional computer model of a heat exchanger. The end product of this project is a computer code that can predict an optimal configuration for a heat exchanger given only a few constraints (input fluids, size, cost, etc.). As VAT computer code can be used to model characteristics (pumping power, temperatures, and cost) of heat exchangers more quickly than traditional CFD or experiment, optimization of every geometric parameter simultaneously can be made. Using design of experiment, DOE and genetric algorithms, GE, to optimize the results of the computer code will improve heat exchanger design.

Revenue Sharing and Information Exchange under Non-Discriminatory Taxation

NARCIS (Netherlands)

Keen, M.; Ligthart, J.E.

2005-01-01

The international exchange of tax information, and its merits compared to withholding taxes, is the central topic in current debates in international tax policy.The purpose of this paper is to characterize and compare the tax regimes that emerge with and without information exchange, under the

Investigation of gas flow characteristics in proton exchange membrane fuel cell

International Nuclear Information System (INIS)

Kwac, Lee Ku; Kim, Hong Gun

2008-01-01

An investigation of electrochemical behavior of PEMFC (proton exchange membrane fuel cell) is performed by using a single-phase two-dimensional finite element analysis. Equations of current balance, mass balance, and momentum balance are implemented to simulate the behavior of PEMFC. The analysis results for the co-flow and counterflow mode of gas flow direction are examined in detail in order to compare how the gas flow direction affects quantitatively. The characteristics of internal properties, such as gas velocity distribution, mass fraction of the reactants, fraction of water and current density distribution in PEMFC are illustrated in the electrode and GDL (gas diffusion layer). It is found that the dry reactant gases can be well internally humidified and maintain high performance in the case of the counter-flow mode without external humidification while it is not advantageous for highly humidified or saturated reactant gases. It is also found that the co-flow mode improves the current density distribution with humidified normal condition compared to the counter-flow mode

Carbon source/sink function of a subtropical, eutrophic lake determined from an overall mass balance and a gas exchange and carbon burial balance

International Nuclear Information System (INIS)

Yang Hong; Xing Yangping; Xie Ping; Ni Leyi; Rong Kewen

2008-01-01

Although studies on carbon burial in lake sediments have shown that lakes are disproportionately important carbon sinks, many studies on gaseous carbon exchange across the water-air interface have demonstrated that lakes are supersaturated with CO 2 and CH 4 causing a net release of CO 2 and CH 4 to the atmosphere. In order to more accurately estimate the net carbon source/sink function of lake ecosystems, a more comprehensive carbon budget is needed, especially for gaseous carbon exchange across the water-air interface. Using two methods, overall mass balance and gas exchange and carbon burial balance, we assessed the carbon source/sink function of Lake Donghu, a subtropical, eutrophic lake, from April 2003 to March 2004. With the overall mass balance calculations, total carbon input was 14 905 t, total carbon output was 4950 t, and net carbon budget was +9955 t, suggesting that Lake Donghu was a great carbon sink. For the gas exchange and carbon burial balance, gaseous carbon (CO 2 and CH 4 ) emission across the water-air interface totaled 752 t while carbon burial in the lake sediment was 9477 t. The ratio of carbon emission into the atmosphere to carbon burial into the sediment was only 0.08. This low ratio indicates that Lake Donghu is a great carbon sink. Results showed good agreement between the two methods with both showing Lake Donghu to be a great carbon sink. This results from the high primary production of Lake Donghu, substantive allochthonous carbon inputs and intensive anthropogenic activity. Gaseous carbon emission accounted for about 15% of the total carbon output, indicating that the total output would be underestimated without including gaseous carbon exchange. - Due to high primary production, substantive allochthonous carbon inputs and intensive anthropogenic acitivity, subtropical, eutrophic Lake Donghu is a great carbon sink

Comparison of Analytical and Numerical Performance Predictions for an International Space Station Node 3 Internal Active Thermal Control System Regenerative Heat Exchanger

Science.gov (United States)

Wise, Stephen A.; Holt, James M.

2002-01-01

The complexity of International Space Station (ISS) systems modeling often necessitates the concurrence of various dissimilar, parallel analysis techniques to validate modeling. This was the case with a feasibility and performance study of the ISS Node 3 Regenerative Heat Exchanger (RHX). A thermo-hydraulic network model was created and analyzed in SINDA/FLUINT. A less complex, closed form solution of the systems dynamics was created using an Excel Spreadsheet. The purpose of this paper is to provide a brief description of the modeling processes utilized, the results and benefits of each to the ISS Node 3 RHX study.

OPDE-The international pipe failure data exchange project

Energy Technology Data Exchange (ETDEWEB)

Lydell, Bengt [OPDE Clearinghouse, 16917 S. Orchid Flower Trail, Vail, AZ 85641-2701 (United States)], E-mail: boylydell@msn.com; Riznic, Jovica [Canadian Nuclear Safety Commission, Operational Engineering Assessment Division, PO Box 1046, Station B, Ottawa, Ont. K1P 5S9 (Canada)], E-mail: jovica.riznic@cnsc-ccsn.gc.ca

2008-08-15

Certain member countries of the Organization for Economic Cooperation and development (OECD) in 2002 established the OECD pipe failure data exchange project (OPDE) to produce an international database on the piping service experience applicable to commercial nuclear power plants. OPDE is operated under the umbrella of the OECD Nuclear Energy Agency (NEA). The Project collects pipe failure data including service-induced wall thinning, part through-wall crack, pinhole leak, leak, and rupture/severance (i.e., events involving large through-wall flow rates up to and beyond the make-up capacity of engineered safeguards systems). The part through-wall events include degradation in excess of design code allowable for pipe wall thinning or crack depth. OPDE also addresses such degradation that could have generic implications regarding the reliability of in-service inspection. Currently the OPDE database includes approximately 3,700 records on pipe failure affecting ASME Code Class 1 through 3 and non-safety-related (non-Code) piping. This paper presents the motivations and objectives behind the establishment of the OPDE project. The paper also summarizes the unique data quality considerations that are associated with the reporting and recording of piping component degradation and failure. An overview of the database content is included to place it in perspective relative to past efforts to systematically collect and evaluate service experience data on piping performance. Finally, a brief summary is given of current database application studies.

OPDE-The international pipe failure data exchange project

International Nuclear Information System (INIS)

Lydell, Bengt; Riznic, Jovica

2008-01-01

Certain member countries of the Organization for Economic Cooperation and development (OECD) in 2002 established the OECD pipe failure data exchange project (OPDE) to produce an international database on the piping service experience applicable to commercial nuclear power plants. OPDE is operated under the umbrella of the OECD Nuclear Energy Agency (NEA). The Project collects pipe failure data including service-induced wall thinning, part through-wall crack, pinhole leak, leak, and rupture/severance (i.e., events involving large through-wall flow rates up to and beyond the make-up capacity of engineered safeguards systems). The part through-wall events include degradation in excess of design code allowable for pipe wall thinning or crack depth. OPDE also addresses such degradation that could have generic implications regarding the reliability of in-service inspection. Currently the OPDE database includes approximately 3,700 records on pipe failure affecting ASME Code Class 1 through 3 and non-safety-related (non-Code) piping. This paper presents the motivations and objectives behind the establishment of the OPDE project. The paper also summarizes the unique data quality considerations that are associated with the reporting and recording of piping component degradation and failure. An overview of the database content is included to place it in perspective relative to past efforts to systematically collect and evaluate service experience data on piping performance. Finally, a brief summary is given of current database application studies

The effects of exchange rate volatility on international trade fl ows: evidence from panel data analysis and fuzzy approach

Directory of Open Access Journals (Sweden)

Robert M. Kunst

2012-06-01

Full Text Available The aim of this paper is to analyze the effects of exchange rate volatility on international trade flows by using two different approaches, the panel data analysis and fuzzy logic, and to compare the results. To a panel with the crosssection dimension of 91 pairs of EU15 countries and with time ranging from 1964 to 2003, an extended gravity model of trade is applied in order to determine theeffects of exchange rate volatility on bilateral trade flows of EU15 countries. The estimated impact is clearly negative, which indicates that exchange rate volatility has a negative influence on bilateral trade flows. Then, this traditional panel approach is contrasted with an alternative investigation based on fuzzy logic. The key elements of the fuzzy approach are to set fuzzy decision rules and to assignmembership functions to the fuzzy sets intuitively based on experience. Both approaches yield very similar results and fuzzy approach is recommended to be used as a complement to statistical methods.

Numerical study of heat transfer characteristics in BOG heat exchanger

Science.gov (United States)

Yan, Yan; Pfotenhauer, John M.; Miller, Franklin; Ni, Zhonghua; Zhi, Xiaoqin

2016-12-01

In this study, a numerical study of turbulent flow and the heat transfer process in a boil-off liquefied natural gas (BOG) heat exchanger was performed. Finite volume computational fluid dynamics and the k - ω based shear stress transport model were applied to simulate thermal flow of BOG and ethylene glycol in a full-sized 3D tubular heat exchanger. The simulation model has been validated and compared with the engineering specification data from its supplier. In order to investigate thermal characteristics of the heat exchanger, velocity, temperature, heat flux and thermal response were studied under different mass flowrates in the shell-side. The shell-side flow pattern is mostly determined by viscous forces, which lead to a small velocity and low temperature buffer area in the bottom-right corner of the heat exchanger. Changing the shell-side mass flowrate could result in different distributions of the shell-side flow. However, the distribution in the BOG will remain in a relatively stable pattern. Heat flux increases along with the shell-side mass flowrate, but the increase is not linear. The ratio of increased heat flux to the mass flow interval is superior at lower mass flow conditions, and the threshold mass flow for stable working conditions is defined as greater than 0.41 kg/s.

Study on Gas-liquid Falling Film Flow in Internal Heat Integrated Distillation Column

Science.gov (United States)

Liu, Chong

2017-10-01

Gas-liquid internally heat integrated distillation column falling film flow with nonlinear characteristics, study on gas liquid falling film flow regulation control law, can reduce emissions of the distillation column, and it can improve the quality of products. According to the distribution of gas-liquid mass balance internally heat integrated distillation column independent region, distribution model of heat transfer coefficient of building internal heat integrated distillation tower is obtained liquid distillation falling film flow in the saturated vapour pressure of liquid water balance, using heat transfer equation and energy equation to balance the relationship between the circulating iterative gas-liquid falling film flow area, flow parameter information, at a given temperature, pressure conditions, gas-liquid flow falling film theory makes the optimal parameters to achieve the best fitting value with the measured values. The results show that the geometric gas-liquid internally heat integrated distillation column falling film flow heat exchange area and import column thermostat, the average temperature has significant. The positive correlation between the heat exchanger tube entrance due to temperature difference between inside and outside, the heat flux is larger, with the increase of internal heat integrated distillation column temperature, the slope decreases its temperature rise, which accurately describes the internal gas-liquid heat integrated distillation tower falling film flow regularity, take appropriate measures to promote the enhancement of heat transfer. It can enhance the overall efficiency of the heat exchanger.

Geothermal heat exchanger with coaxial flow of fluids

Directory of Open Access Journals (Sweden)

Pejić Dragan M.

2005-01-01

Full Text Available The paper deals with a heat exchanger with coaxial flow. Two coaxial pipes of the secondary part were placed directly into a geothermal boring in such a way that geothermal water flows around the outer pipe. Starting from the energy balance of the exchanger formed in this way and the assumption of a study-state operating regime, a mathematical model was formulated. On the basis of the model, the secondary circle output temperature was determined as a function of the exchanger geometry, the coefficient of heat passing through the heat exchange areas, the average mass isobaric specific heats of fluid and mass flows. The input temperature of the exchanger secondary circle and the temperature of the geothermal water at the exit of the boring were taken as known values. Also, an analysis of changes in certain factors influencing the secondary water temperature was carried out. The parameters (flow temperature of the deep boring B-4 in Sijarinska Spa, Serbia were used. The theoretical results obtained indicate the great potential of this boring and the possible application of such an exchanger.

Changes in water mass exchange between the NW shelf areas and the North Atlantic and their impact on nutrient/carbon cycling

Science.gov (United States)

Gröger, Matthias; Maier-Reimer, Ernst; Mikolajewicz, Uwe; Segschneider, Joachim; Sein, Dimitry

2010-05-01

Despite their comparatively small extension on a global scale, shelf areas are of interest for several economic reasons and climatic processes related to nutrient cycling, sea food supply, and biological productivity. Moreover, they constitute an important interface for nutrients, pollutants and freshwater on their pathway from the continents to the open ocean. This modelling study aims to investigate the spatial and temporal variability of water mass exchange between the North Atlantic and the NW European shelf and their impact on nutrient/carbon cycling and biological productivity. For this, a new modeling approach has been set up which bridges the gap between pure shelf models where water mass transports across the model domain too strongly depend on the formulation of open boundaries and global models suffering under their too coarse resolution in shelf regions. The new model consists of the global ocean and carbon cycle model MPIOM/HAMOCC with strongly increased resolution in the North Sea and the North Atlantic coupled to the regional atmosphere model REMO. The model takes the full luni-solar tides into account. It includes further a 12 layer sediment module with the relevant pore water chemistry. The main focus lies on the governing mechanisms of water mass exchange across the shelf break and the imprint on shelf biogeochemistry. For this, artificial tracers with a prescribed decay rate have been implemented to distinguish waters arriving from polar and shelf regions and those that originate from the tropics. Experiments were carried out for the years 1948 - 2007. The relationship to larger scale circulation patterns like the position and variability of the subtropical and subpolar gyres is analyzed. The water mass exchange is analyzed with respect to the nutrient concentration and productivity on the European shelf areas. The implementation of tides leads to an enhanced vertical mixing which causes lower sea surface temperatures compared to simulations

Policies and Procedures for Foreign Exchange Agencies. First Edition.

Science.gov (United States)

Hartman, Donald D.

The guide details the policy of the Jefferson County (Alabama) Board of Education policy concerning international exchange of students (travel both to and from United States) in elementary and secondary grades. The first section specifies the standards by which the county will evaluate all international exchange agencies concerning structure,…

Staff Exchange or Legal Alien Programs

DEFF Research Database (Denmark)

Jørgensen, Rune Nørgaard

2016-01-01

SRA would very much like to support the exchange of best practice between members throughout the year and the Membership Committee is presently looking into the opportunities for a Staff Exchange or Legal Alien Program. However the International Section has already had the chance to provide...

Probing Conformational Dynamics of Tau Protein by Hydrogen/Deuterium Exchange Mass Spectrometry

Science.gov (United States)

Huang, Richard Y.-C.; Iacob, Roxana E.; Sankaranarayanan, Sethu; Yang, Ling; Ahlijanian, Michael; Tao, Li; Tymiak, Adrienne A.; Chen, Guodong

2018-01-01

Fibrillization of the microtubule-associated protein tau has been recognized as one of the signature pathologies of the nervous system in Alzheimer's disease, progressive supranuclear palsy, and other tauopathies. The conformational transition of tau in the fibrillization process, tau monomer to soluble aggregates to fibrils in particular, remains unclear. Here we report on the use of hydrogen/deuterium exchange mass spectrometry (HDX-MS) in combination with other biochemical approaches, including Thioflavin S fluorescence measurements, enzyme-linked immunosorbent assay (ELISA), and Western blotting to understand the heparin-induced tau's fibrillization. HDX-MS studies including anti-tau antibody epitope mapping experiments provided molecular level details of the full-length tau's conformational dynamics and its regional solvent accessibility upon soluble aggregates formation. The results demonstrate that R3 region in the full-length tau's microtubule binding repeat region (MTBR) is stabilized in the aggregation process, leaving both N and C terminal regions to be solvent exposed in the soluble aggregates and fibrils. The findings also illustrate the practical utility of orthogonal analytical methodologies for the characterization of protein higher order structure. [Figure not available: see fulltext.

Assessment of exchange of crop in view of change climate and International Treaties.

Science.gov (United States)

Singh, Anil Kumar; Pedapati, Annitaa; Manibhushan

2015-01-01

To meet the UN millennium development goal of reducing the number of hungry people to half by 2015, there is utmost need to breed potentially high yielding varieties to match up the requirement along with corrective measures to bridge the gap between the potential yield and yield harvested by farmers. The scenario has changed from free access to limited access of plant genetic resources (PGR) and therefore, it is important to understand the issues in view of national and international agreements, intellectual property rights (IPR'S), climate change conditions and expanded scope of breeders and farmers rights for developed genotypes. For efficient management of PGR, developing countries need to understand the implications of PGR related IPR'S as stronger IPR'S in developed countries could have harmful effects by reduced exchange of genetic resources from developed countries. Keeping in view the existing realities every possible effort should be taken for enrichment of crop gene pool by introducing them from each and every corner of the globe. Keeping these facts in view this paper describes the priorities for introduction and exchange of important crop groups/crops along with some of their potential wild and weedy relatives and thrust has been given to generate awareness among the workers engaged in the breeders/crop improvement works. Information provided in this presentation can be utilized by prospective crop improvement works to plan to meet out the nationalfood security.

Compact heat and mass exchangers of the plate fin type in thermal sorption systems: Application in an absorption heat pump with the working pair CH3OH-LiBr/ZnBr2

Science.gov (United States)

Becker, Harry

The possible application of Compact Heat and Mass Exchangers (CHME) in a gas fired Absorption Heat Pump (AHP) for domestic heating is studied. The above mentioned heat and mass exchangers are of the plate type. The space between the parallel and plain plates is filled up with corrugated plates of a certain height. The plain and finned plates are stacked and welded together. This gives a heat and mass exchanger which is very compact, expressed by a high area density (m2/m3). This leads to heat and mass transfer processes with small temperature and concentration differences. For testing purposes a pilot plant was built using the above type of components in order to test their heat and/or mass transfer performance. Only the generator is of the Shell And Tube (SAT) type. As the working pair, CH3OH - LiBr/ ZnBr2 was chosen, with the alcohol as the solvent and the salt mixture as the absorbent. This leads to sub atmospheric working pressures with only solvent in the vapor phase. Three series of experiments have been carried out, during which the input parameters were varied over a certain range. It is concluded that the plate fin CHMES are very suitable for application in an AHP for domestic heating purposes.

22 CFR 62.28 - International visitors.

Science.gov (United States)

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false International visitors. 62.28 Section 62.28 Foreign Relations DEPARTMENT OF STATE PUBLIC DIPLOMACY AND EXCHANGES EXCHANGE VISITOR PROGRAM Specific Program Provisions § 62.28 International visitors. (a) Purpose. The international visitor category is for...

[Significance of amnioinfusion and amniotic fluid exchange under continuous internal fetal heart rate monitoring for management of fetal distress during labor].

Science.gov (United States)

Zhao, S; Ai, L; Zhang, H

2000-01-01

To discuss the significance of amnioinfusion and amniotic fluid exchange under continuous internal fetal heart rate (FHR) monitoring for management of fetal distress during labor. 136 cases with frequent variable deceleration (VD) and meconium stained amniotic fluid during labor were divided into two groups: the study group (68 cases) and the control group (68 cases). The former were treated by amnioinfusion and amniotic fluid exchange, while oxygen inhalation, change of body position, and intravenous infusion for the control group. In the study group, VD disappeared or relieved in 62 cases obviously, and the efficacy rate reached 91.2% (62/68). 48 cases with II degree meconium stained amniotic fluid were treated by amniotic fluid exchange, amniotic fluid became clear or turned to I degree stained in 39 cases. In the control group, VD relieved in 20 cases, the efficacy rate was 19.4%, significantly lower than that of the study group (P 0.05). Amnioinfusion and AF exchange during labor are one of the effective treatment methods for fetal distress and prevention for MAS.

Self-consistent one-gluon exchange in soliton bag models

International Nuclear Information System (INIS)

Dodd, L.R.; Adelaide Univ.; Williams, A.G.

1988-01-01

The treatment of soliton bag models as two-point boundary value problems is extended to include self-consistent one-gluon exchange interactions. The colour-magnetic contribution to the nucleon-delta mass splitting is calculated self-consistently in the mean-field, one-gluon-exchange approximation for the Friedberg-Lee and Nielsen-Patkos models. Small glueball mass parameters (m GB ∝ 500 MeV) are favoured. Comparisons with previous calculations are made. (orig.)

Project to promote exchange of international information on environmental technologies; Kankyo gijutsu kokusai joho koryu sokushin jigyo

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

Mutual information exchange at international levels is important for practical application of global environment preservation technologies, whereas the APEC Virtual Center was established in fiscal 1997. Fiscal 1998 has discussed the future functions of the Virtual Center, and carried out the following matters to improve the functions and achieve its stable operation. Discussions were given on common use with the centers of other countries and regions of the specifications of classification systems for information areas and provided information that are provided by the Virtual Center. Visits were made to sub-managing countries and regions for smooth operation of the study groups, and opinions were exchanged. Visits were made to coordinators and contact points established in each country and region when the Center was founded in fiscal 1997. A visit was made to the U.S. Environmental Protection Agency to exchange opinions on coordination measures with the Cleaner Production Strategy of the U.S.A. being a project similar to the subject project. In order to strengthen the Japan's Center, attempts were made to expand the linking information to wider scope. Special pages publishing concentratedly the items of information that the users are interested were prepared as part of the information provision. (NEDO)

Rapid Screening for Potential Epitopes Reactive with a Polycolonal Antibody by Solution-Phase H/D Exchange Monitored by FT-ICR Mass Spectrometry

Science.gov (United States)

Zhang, Qian; Noble, Kyle A.; Mao, Yuan; Young, Nicolas L.; Sathe, Shridhar K.; Roux, Kenneth H.; Marshall, Alan G.

2013-07-01

The potential epitopes of a recombinant food allergen protein, cashew Ana o 2, reactive to polyclonal antibodies, were mapped by solution-phase amide backbone H/D exchange (HDX) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). Ana o 2 polyclonal antibodies were purified in the serum from a goat immunized with cashew nut extract. Antibodies were incubated with recombinant Ana o 2 (rAna o 2) to form antigen:polyclonal antibody (Ag:pAb) complexes. Complexed and uncomplexed (free) rAna o 2 were then subjected to HDX-MS analysis. Four regions protected from H/D exchange upon pAb binding are identified as potential epitopes and mapped onto a homologous model.

Exchange rates and climate change: An application of fund

NARCIS (Netherlands)

Tol, R.S.J.

2006-01-01

As economic and emissions scenarios assume convergence of per capita incomes, they are sensitivity to the exchange rate used for international comparison. Particularly, developing countries are project to grow slower with a purchasing power exchange rate than with a market exchange rate. Different

Assessing the Merits of International Service-Learning in Developing Professionalism in Mass Communication

Science.gov (United States)

Motley, Phillip; Sturgill, Amanda

2013-01-01

This project assessed how an international service-learning course affected mass communication students' knowledge of professionalism. Using written reflections and focus group transcripts from four courses that took place in Central America, we observed that placing students in immersive environments, where they are able to work on authentic…

Simultaneous measurement of proline and related compounds in oak leaves by high-performance ligand-exchange chromatography and electrospray ionization mass spectrometry for environmental stress studies.

Science.gov (United States)

Oufir, Mouhssin; Schulz, Nadine; Sha Vallikhan, Patan Shaik; Wilhelm, Eva; Burg, Kornel; Hausman, Jean-Francois; Hoffmann, Lucien; Guignard, Cedric

2009-02-13

A mass spectrometer was coupled to high-performance ligand-exchange liquid chromatography (HPLEC) for simultaneous analysis of stress associated solutes such as proline, hydroxyproline, methylproline, glycine betaine and trigonelline extracted from leaves of drought stressed oaks and an internal standard namely N-acetylproline. Methanol/chloroform/water extracts were analyzed using an Aminex HPX-87C column and specifically quantified by the positive ion mode of an electrospray ionisation-mass spectrometry (ESI-MS) in single ion monitoring (SIM) mode. The recovery of N-acetyl proline added to oak leaf extracts ranged from 85.2 to 122.1% for an intra-day study. Standard calibration curves showed good linearity in the measured range from 0.3125 to 10micromolL(-1) with the lowest correlation coefficient of 0.99961 for trigonelline. The advantages of this alternative procedure, compared to previously published methods using fluorescence or amperometric detections, are the simultaneous and direct detection of osmoprotectants in a single chromatographic run, a minimal sample preparation, a good specificity and reduced limits of quantification, ranging from 0.1 to 0.6micromolL(-1). Fifty-six days of water deficit exposure resulted in increased foliar free proline levels (2.4-fold, P<0.001, 155micromolg(-1) FW) and glycine betaine contents (2.5-fold, P<0.05, 175micromolg(-1) FW) of drought stressed oak compared to control.

PLT and PDX perpendicular charge-exchange analyzers

International Nuclear Information System (INIS)

Mueller, D.; Hammett, G.W.; McCune, D.C.

1986-01-01

The perpendicular charge-exchange systems used on the poloidal divertor experiment and the Princeton large torus are comprised of ten-channel, mass-resolved, charge-exchange analyzers. Results from these systems indicate that instrumental effects can lead to erroneous temperature measurements during deuterium neutral beam injection or at low hydrogen concentrations

A new assessment of floating exchange rates

OpenAIRE

Waimann, D. R.

1981-01-01

The switch to floating exchange rates during the 1970s has given economists the first comprehensive opportunity to assess the arguments for and against floating. Much new work has been done on various aspects of floating exchange rate behaviour. This article attempts a limited survey of the evidence concerning two important issues—whether floating exchange rates are inherently unstable and whether they harm international trade.

Impacts of Firms’ Internal Information Environment on Tax Avoidance (Case Study: Companies Listed in Tehran’s Stock Exchange

Directory of Open Access Journals (Sweden)

Jahanbakhsh Ghafoori

2017-02-01

Full Text Available The main purpose of this study is to investigate the impacts of firms’ internal information environment on tax avoidance. The research method includes a data panel and is generally of semi-experimental fashion. The population of research is consisted of the entire companies and firms listed in Tehran’s stock exchange as 496 firms from the beginning of 2007 until the end of financial year of 2014. Among the population, a number of 86 firms were selected as the sample through systematic omitting method. For the purpose of data analysis, the tests of T and multivariate linear regression were incorporated into the study. Results indicate that impact of quality of internal information on tax avoidance is higher in those companies in which information play a more important role. Firms which operate under geographic dispersion make more use of the quality of their internal information, because this information helps them towards reduced tax avoidance. High quality of internal information and commercial dispersion force these firms towards avoiding larger taxes. In addition, quality of internal information is not effective on firms which are under reconstruction status.

Impacts of Firms’ Internal Information Environment on Tax Avoidance (Case Study: Companies Listed In Tehran’s Stock Exchange

Directory of Open Access Journals (Sweden)

Jahanbakhsh Ghafoori

2017-04-01

Full Text Available The main purpose of this study is to investigate the impacts of firms’ internal information environment on tax avoidance. The research method includes a data panel and is generally of semi-experimental fashion. The population of research is consisted of the entire companies and firms listed in Tehran’s stock exchange as 496 firms from the beginning of 2007 until the end of financial year of 2014. Among the population, a number of 86 firms were selected as the sample through systematic omitting method. For the purpose of data analysis, the tests of T and multivariate linear regression were incorporated into the study. Results indicate that impact of quality of internal information on tax avoidance is higher in those companies in which information play a more important role. Firms which operate under geographic dispersion make more use of the quality of their internal information, because this information helps them towards reduced tax avoidance. High quality of internal information and commercial dispersion force these firms towards avoiding larger taxes. In addition, quality of internal information is not effective on firms which are under reconstruction status.

Search for a new exchange-rate regime.

Science.gov (United States)

Williamson, J

1987-07-31

The regime of unmanaged floating exchange rates was implicitly judged a failure when, with the Plaza Agreement, attempts at cooperative exchange-rate management were reintroduced primarily because of concern at the size of misalignments. Any satisfactory successor regime will need to limit misalignments while retaining the genuine social benefits of exchange-rate flexibility. It is argued that a system of target zones for exchange rates, ideally embedded in a more comprehensive set of guidelines for international economic policy coordination, could best reconcile these needs.

Chemical exchange in novel spirobicyclic zwitterionic Janovsky complexes using dynamic 1H NMR spectroscopy.

Science.gov (United States)

Culf, A S; Cuperlović-Culf, M; Ouellette, R J

2009-02-01

Highly coloured Janovsky complexes have been known for over 120 years, being used in many colourimetric analytical procedures. In this present study, two novel and stable nitrocyclohexadienyl spirobicyclic, zwitterionic Janovsky anionic hydantoin sigma-complexes, rac-1,3-diisopropyl-6-nitro-2,4-dioxo-1,3-diazaspiro[4.5]deca-6,9-dien-8-ylideneazinate, ammonium internal salt (1) and 1,3-diisopropyl-2,4-dioxo-1,3-diazaspiro[4.5]deca-6,9-dien-8-ylideneazinate, ammonium internal salt (2) have been prepared and characterised by NMR, electrospray ionization mass spectrometry (ESI-MS) and UV/visible methods. For the p-mononitro-substituted complex (2), we discovered chemical exchange behaviour using 1D saturation transfer and 2D exchange spectroscopy (EXSY) (1)H NMR techniques. The coalescence temperature was determined to be 62 degrees C in d(3)-acetonitrile. Analysis of these data provided a Gibbs free energy of activation, DeltaG double dagger, of + 67 kJ mole(-1), a rate constant, k, coalescence of 220 Hz and an equilibrium constant, K(eqm), of 0.98 as estimates of the exchange process in this solvent. Of the two mechanisms proposed for this fluxional behaviour, ring opening to a substituted benzene or proton exchange, a further theoretical modelling study of 1D (1)H NMR spectra was able to confirm that simple proton exchange between the two nitrogen sites of the hydantoin ring provided an accurate simulation of the observed experimental evidence. Interestingly, the o,p-dinitro-substituted complex (1) did not show any chemical exchange behaviour up to 150 degrees C in d(3)-acetonitrile (to 75 degrees C) and d(6)-dimethyl sulfoxide (DMSO). Molecular modelling at the MM2 level suggests that steric collisions of an N-acyl isopropyl substituent of the hydantoin ring with the ortho-nitro group of the spirofused cyclohexadienyl ring prevents the proposed proton exchange mechanism occurring in this case. 2008 Crown in the right of Canada. Published by John Wiley & Sons, Ltd.

Electromechanical phase transition of a dielectric elastomer tube under internal pressure of constant mass

Directory of Open Access Journals (Sweden)

Song Che

2017-05-01

Full Text Available The electromechanical phase transition for a dielectric elastomer (DE tube has been demonstrated in recent experiments, where it is found that the unbulged phase gradually changed into bulged phase. Previous theoretical works only studied the transition process under pressure control condition, which is not consistent with the real experimental condition. This paper focuses on more complex features of the electromechanical phase transition under internal pressure of constant mass. We derive the equilibrium equations and the condition for coexistent states for a DE tube under an internal pressure, a voltage through the thickness and an axial force. We find that under mass control condition the voltage needed to maintain the phase transition increases as the process proceeds. We analyze the entire process of electromechanical phase transition and find that the evolution of configurations is also different from that for pressure control condition.

International portfolio flows and exchange rate volatility for emerging markets

OpenAIRE

Caporale, Guglielmo Maria; Ali, Faek Menla; Spagnolo, Fabio; Spagnolo, Nicola

2015-01-01

This paper investigates the effects of equity and bond portfolio inflows on exchange rate volatility, using monthly bilateral data for the US vis-a-vis eight Asian developing and emerging countries (India, Indonesia, South Korea, Pakistan, Hong Kong, Thailand, the Philippines, and Taiwan) over the period 1993:01-2012:11, and estimating a time-varying transition probability Markov-switching model. We find that net equity (bond) inflows drive the exchange rate to a high (low) volatility state. ...

Study the Effect of the Flow on the Performance of a shell and Tube Type Heat Exchanger using Experimental Design Technique

Directory of Open Access Journals (Sweden)

Zuher Hassan Abdullah

2016-10-01

Full Text Available In the current research an experimental study was done to show the effect of pulse flow on the effectiveness of shell and tube type heat exchanger. the study was in the case of steady and pulse flows with a changing mass flow rate of hot water flowing inside the pipes of the heat exchanger for the range between (0.0273-0.0819 kg / s  at fix mass flow rate of cold water that flows through the shell and on the outer surface of the pipes when (0.0416 kg / s, to obtain pulsing a used was solenoid valve. The research aims to measure the percentage effect of independent factors which were presenting the mass flow rate of hot water, flow type and the surrounding environment conditions of the experimental side upon shell and tube type heat exchanger performance using experimental design technique at the significant level (0.05.The results derived from the experimental tests showed that pulse flow leads to increase internal heat transfer coefficient (hi comparing with its value in the steady flow and the highest increase was by (9.75% at a mass flow rate of hot water (0.0416 kg / s and increases the overall heat transfer coefficient (U, where the highest percentage was by 4.68% at a mass flow rate of hot water (0.0416kg/s. The results also showed increasing both the number of transmitted units (NTU and the effectiveness of the shell and tube type heat exchanger ( in the case of pulse flow of its value in the steady flow and the highest percentage of increase occurring was (4.75% and (1.85%, respectively, and at the mass flow rate of hot water (0.0416 kg / s. Percentage effect of mass flow rate of hot water was (97%, 97.42%, 95.5%, 99.48% and the percentage effect of each flow type and the errors were (2.8%, 2.25%, 2.44%, 0.4% and (0. 2, 0.33%, 2.06%, 0.12 respectively

Shanghai and Hong Kong Join Efforts for Oil Futures Exchanges

Institute of Scientific and Technical Information of China (English)

无

2003-01-01

@@ Shanghai Futures Exchange (SHFE) and Hong Kong Exchanges and Clearing Limited (HKEx) announced in midApril they will jointly introduce crude oil futures. The two exchanges will jointly develop an energy derivatives market that serves both Chinese and international investors,according to a memorandum of understanding (MOU) signed between the two exchanges.

Comparison of Analytical and Numerical Performance Predictions for a Regenerative Heat Exchanger in the International Space Station Node 3 Internal Active Thermal Control System

Science.gov (United States)

Wise, Stephen A.; Holt, James M.; Turner, Larry D. (Technical Monitor)

2001-01-01

The complexity of International Space Station (ISS) systems modeling often necessitates the concurrence of various dissimilar, parallel analysis techniques to validate modeling. This was the case with a feasibility and performance study of the ISS Node 3 Regenerative Heat Exchanger (RHX). A thermo-hydraulic network model was created and analyzed in SINDA/FLUINT. A less complex, closed form solution of the system dynamics was created using Excel. The purpose of this paper is to provide a brief description of the modeling processes utilized, the results and benefits of each to the ISS Node 3 RHX study.

Noninvasive mapping of water diffusional exchange in the human brain using filter-exchange imaging.

Science.gov (United States)

Nilsson, Markus; Lätt, Jimmy; van Westen, Danielle; Brockstedt, Sara; Lasič, Samo; Ståhlberg, Freddy; Topgaard, Daniel

2013-06-01

We present the first in vivo application of the filter-exchange imaging protocol for diffusion MRI. The protocol allows noninvasive mapping of the rate of water exchange between microenvironments with different self-diffusivities, such as the intracellular and extracellular spaces in tissue. Since diffusional water exchange across the cell membrane is a fundamental process in human physiology and pathophysiology, clinically feasible and noninvasive imaging of the water exchange rate would offer new means to diagnose disease and monitor treatment response in conditions such as cancer and edema. The in vivo use of filter-exchange imaging was demonstrated by studying the brain of five healthy volunteers and one intracranial tumor (meningioma). Apparent exchange rates in white matter range from 0.8±0.08 s(-1) in the internal capsule, to 1.6±0.11 s(-1) for frontal white matter, indicating that low values are associated with high myelination. Solid tumor displayed values of up to 2.9±0.8 s(-1). In white matter, the apparent exchange rate values suggest intra-axonal exchange times in the order of seconds, confirming the slow exchange assumption in the analysis of diffusion MRI data. We propose that filter-exchange imaging could be used clinically to map the water exchange rate in pathologies. Filter-exchange imaging may also be valuable for evaluating novel therapies targeting the function of aquaporins. Copyright © 2012 Wiley Periodicals, Inc.

Letter: Observation of the 16O/18O exchange during electrospray ionization.

Science.gov (United States)

Kostyukevich, Yury; Kononikhin, Alexey; Popov, Igor; Nikolaev, Eugene

2015-01-01

Isotopic exchange approach coupled to high-resolution mass spectrometry has become the power analytical approach for a wide range of analytical and bioanalyticall applications. Considerable efforts have been dedicated to developing fast exchange techniques directly in the ionization source. But all such methods are limited to the hydrogen/deuterium exchange approaches. In this paper we demonstrate that certain types of oxygen atoms can also be exchanged for (18)O on the time scale of the ionization process. Using HIO(3) and NaIO(4) and by infusing the heavy water H(2)(18)O in the ESI source we have demonstrated that it is possible to obtain a high level of oxygen exchange. It was observed that the rate of this exchange depends to a large extent on the temperature of the desolvating capillary of the mass spectrometer. Several other species, such as peptides, oligonucleotides and low weight organic molecules, were subjected to in-ESI (16)O/(18)O exchange but the exchange was not observed.

Aberrant internal carotid artery presenting as a retrotympanic vascular mass

International Nuclear Information System (INIS)

Nicolay, Simon; De Foer, Bert; Bernaerts, Anja; Van Dinther, Joost; Parizel, Paul M

2014-01-01

We report a case of a young woman with an aberrant right internal carotid artery (ICA) presenting as a retrotympanic reddish mass. This variant of the ICA represents the collateral pathway that is formed as a result of an embryological agenesis of the cervical segment of the ICA. The embryonic inferior tympanic artery is recruited to bypass the absent carotid segment. This hypertrophied vessel may be seen otoscopically and wrongfully considered to be a vascular middle ear tumor. Informing the otorhinolaryngologist of this important vascular variant not only obviates biopsy but also helps in careful preoperative planning of eventual middle ear procedures

Invariant mass spectroscopy of {sup 19,17}C and {sup 14}B using proton inelastic and charge-exchange reactions

Energy Technology Data Exchange (ETDEWEB)

Satou, Y., E-mail: satou@phya.snu.ac.k [Department of Physics and Astronomy, Seoul National University, Seoul (Korea, Republic of); Nakamura, T. [Department of Physics, Tokyo Institute of Technology, Tokyo (Japan); Fukuda, N. [Institute of Physical and Chemical Research (RIKEN), Saitama (Japan); Sugimoto, T.; Kondo, Y.; Matsui, N.; Hashimoto, Y.; Nakabayashi, T.; Okumura, Y.; Shinohara, M. [Department of Physics, Tokyo Institute of Technology, Tokyo (Japan); Motobayashi, T.; Yanagisawa, Y.; Aoi, N.; Takeuchi, S.; Gomi, T.; Togano, Y. [Institute of Physical and Chemical Research (RIKEN), Saitama (Japan); Kawai, S. [Department of Physics, Rikkyo University, Tokyo (Japan); Sakurai, H. [Institute of Physical and Chemical Research (RIKEN), Saitama (Japan); Ong, H.J.; Onishi, T.K. [Department of Physics, University of Tokyo, Tokyo (Japan)

2010-03-01

The neutron-rich carbon isotopes {sup 19,17}C and the boron isotope {sup 14}B have been investigated, respectively, by the proton inelastic and charge-exchange reactions on a liquid hydrogen target at around 70 MeV/nucleon. The invariant mass method in inverse kinematics was employed to map the energy spectrum above the neutron decay threshold of the residual nuclei. New states on carbon isotopes are reported. An experimental capability of extracting beta-decay strengths via forward angle (p,n) cross sections on unstable nuclei is shown.

Hydrogen exchange mass spectrometry of bacteriorhodopsin reveals light-induced changes in the structural dynamics of a biomolecular machine.

Science.gov (United States)

Pan, Yan; Brown, Leonid; Konermann, Lars

2011-12-21

Many proteins act as molecular machines that are fuelled by a nonthermal energy source. Examples include transmembrane pumps and stator-rotor complexes. These systems undergo cyclic motions (CMs) that are being driven along a well-defined conformational trajectory. Superimposed on these CMs are thermal fluctuations (TFs) that are coupled to stochastic motions of the solvent. Here we explore whether the TFs of a molecular machine are affected by the occurrence of CMs. Bacteriorhodopsin (BR) is a light-driven proton pump that serves as a model system in this study. The function of BR is based on a photocycle that involves trans/cis isomerization of a retinal chromophore, as well as motions of transmembrane helices. Hydrogen/deuterium exchange (HDX) mass spectrometry was used to monitor the TFs of BR, focusing on the monomeric form of the protein. Comparative HDX studies were conducted under illumination and in the dark. The HDX kinetics of BR are dramatically accelerated in the presence of light. The isotope exchange rates and the number of backbone amides involved in EX2 opening transitions increase roughly 2-fold upon illumination. In contrast, light/dark control experiments on retinal-free protein produced no discernible differences. It can be concluded that the extent of TFs in BR strongly depends on photon-driven CMs. The light-induced differences in HDX behavior are ascribed to protein destabilization. Specifically, the thermodynamic stability of the dark-adapted protein is estimated to be 5.5 kJ mol(-1) under the conditions of our work. This value represents the free energy difference between the folded state F and a significantly unfolded conformer U. Illumination reduces the stability of F by 2.2 kJ mol(-1). Mechanical agitation caused by isomerization of the chromophore is transferred to the surrounding protein scaffold, and subsequently, the energy dissipates into the solvent. Light-induced retinal motions therefore act analogously to an internal heat

Parametric study of a capillary tube-suction line heat exchanger in a transcritical CO2 heat pump cycle

International Nuclear Information System (INIS)

Agrawal, Neeraj; Bhattacharyya, Souvik

2008-01-01

The capillary tube in a transcritical CO 2 system behaves differently as temperature and pressure are two independent parameters unlike those in a sub-critical cycle. A capillary tube-suction line heat exchanger (CL-SLHX) in a transcritical vapour compression cycle considering homogeneous two-phase flow is modelled in this study based on mass, energy and momentum equations. Effects of gas cooler temperature, evaporator temperature and internal diameter of capillary tube are investigated. Heat transfer rate is observed to be influenced by refrigerant quality, mass flow rate and the prevailing temperature difference. Heat transfer rate variation with gas cooler temperature is unique, recording an initial increase followed by a decrease. Frictional pressure drop influences the heat transfer; consequently, chances of re-condensation of refrigerant vapour are very marginal. Larger diameter of capillary tube leads to increase in refrigerant mass flow rate and increase in heat transfer rate as well. Shorter inlet adiabatic capillary length with larger heat exchanger length is better for heat transfer. This study is an attempt to dispel the scepticism prevailing in transcritical CO 2 system community overemphasising the need for a throttle valve to control the optimum discharge pressure

qcML: an exchange format for quality control metrics from mass spectrometry experiments.

Science.gov (United States)

Walzer, Mathias; Pernas, Lucia Espona; Nasso, Sara; Bittremieux, Wout; Nahnsen, Sven; Kelchtermans, Pieter; Pichler, Peter; van den Toorn, Henk W P; Staes, An; Vandenbussche, Jonathan; Mazanek, Michael; Taus, Thomas; Scheltema, Richard A; Kelstrup, Christian D; Gatto, Laurent; van Breukelen, Bas; Aiche, Stephan; Valkenborg, Dirk; Laukens, Kris; Lilley, Kathryn S; Olsen, Jesper V; Heck, Albert J R; Mechtler, Karl; Aebersold, Ruedi; Gevaert, Kris; Vizcaíno, Juan Antonio; Hermjakob, Henning; Kohlbacher, Oliver; Martens, Lennart

2014-08-01

Quality control is increasingly recognized as a crucial aspect of mass spectrometry based proteomics. Several recent papers discuss relevant parameters for quality control and present applications to extract these from the instrumental raw data. What has been missing, however, is a standard data exchange format for reporting these performance metrics. We therefore developed the qcML format, an XML-based standard that follows the design principles of the related mzML, mzIdentML, mzQuantML, and TraML standards from the HUPO-PSI (Proteomics Standards Initiative). In addition to the XML format, we also provide tools for the calculation of a wide range of quality metrics as well as a database format and interconversion tools, so that existing LIMS systems can easily add relational storage of the quality control data to their existing schema. We here describe the qcML specification, along with possible use cases and an illustrative example of the subsequent analysis possibilities. All information about qcML is available at http://code.google.com/p/qcml. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

qcML: An Exchange Format for Quality Control Metrics from Mass Spectrometry Experiments*

Science.gov (United States)

Walzer, Mathias; Pernas, Lucia Espona; Nasso, Sara; Bittremieux, Wout; Nahnsen, Sven; Kelchtermans, Pieter; Pichler, Peter; van den Toorn, Henk W. P.; Staes, An; Vandenbussche, Jonathan; Mazanek, Michael; Taus, Thomas; Scheltema, Richard A.; Kelstrup, Christian D.; Gatto, Laurent; van Breukelen, Bas; Aiche, Stephan; Valkenborg, Dirk; Laukens, Kris; Lilley, Kathryn S.; Olsen, Jesper V.; Heck, Albert J. R.; Mechtler, Karl; Aebersold, Ruedi; Gevaert, Kris; Vizcaíno, Juan Antonio; Hermjakob, Henning; Kohlbacher, Oliver; Martens, Lennart

2014-01-01

Quality control is increasingly recognized as a crucial aspect of mass spectrometry based proteomics. Several recent papers discuss relevant parameters for quality control and present applications to extract these from the instrumental raw data. What has been missing, however, is a standard data exchange format for reporting these performance metrics. We therefore developed the qcML format, an XML-based standard that follows the design principles of the related mzML, mzIdentML, mzQuantML, and TraML standards from the HUPO-PSI (Proteomics Standards Initiative). In addition to the XML format, we also provide tools for the calculation of a wide range of quality metrics as well as a database format and interconversion tools, so that existing LIMS systems can easily add relational storage of the quality control data to their existing schema. We here describe the qcML specification, along with possible use cases and an illustrative example of the subsequent analysis possibilities. All information about qcML is available at http://code.google.com/p/qcml. PMID:24760958

Respiratory system. Part 2: Gaseous exchange.

Science.gov (United States)

McLafferty, Ella; Johnstone, Carolyn; Hendry, Charles; Farley, Alistair

This article, which isthe last in the life sciences series and the second of two articles on the respiratory system, describes gaseous exchange in the lungs, transport of oxygen and carbon dioxide, and internal and external respiration. The article concludes with a brief consideration of two conditions that affect gas exchange and transport: carbon monoxide poisoning and chronic obstructive pulmonary disease.

Effective international information exchange as a key element of modern tax systems: promises and pitfalls of the OECD’s common reporting standard

Directory of Open Access Journals (Sweden)

Stjepan Gadzo

2017-06-01

Full Text Available Today’s global economic environment is characterized by the high mobility of capital and labour across national borders. Against the backdrop of a legal framework governing taxation of cross-border income, this may lead to double taxation on the one hand, as well as provide opportunities for tax evasion and tax avoidance on the other. It is well-established that a prerequisite for effective taxation of foreign-sourced income earned by “domestic taxpayers” (i.e. tax residents is the system of administrative co-operation across national boundaries, mainly in the form of exchange of tax-relevant information between tax authorities. Since the lack of information-exchange mechanisms is linked with tax havens and the proliferation of “harmful tax practices”, the OECD put the issue high on the global political agenda as early as 1998. Further developments strengthened the importance of the exchange of information, leading to the so-called “big bang” of 2009, i.e. to a significant increase in the number of concluded tax information exchange agreements, caused by the growing concern about international tax evasion and avoidance in the post-crisis period.Nowadays the so-called automatic exchange of information (AEOI between tax authorities has emerged as a new global standard. This is mostly due to the development of specific national and international models, aimed at enhancing intergovernmental cooperation in fighting offshore tax evasion. In this regard special attention should be drawn to the 2014 release of the OECD’s Common Reporting Standard (CRS, which is based on the idea that banks and other financial institutions should play a crucial role in providing information on taxpayer’s income and assets to tax authorities around the globe.The aim of this paper is to explore some of the most important implications of the adoption of the CRS as a global AEOI model. While there are marked advantages of the new standard - mainly related

Observational signatures of past mass-exchange episodes in massive binaries: the case of LSS 3074

Science.gov (United States)

Raucq, F.; Gosset, E.; Rauw, G.; Manfroid, J.; Mahy, L.; Mennekens, N.; Vanbeveren, D.

2017-05-01

Context. The role of mass and momentum exchanges in close massive binaries is very important in the subsequent evolution of the components. Such exchanges produce several observational signatures such as asynchronous rotation and altered chemical compositions, that remain after the stars detach again. Aims: We investigated these effects for the close O-star binary LSS 3074 (O4 f + O6-7:(f):), which is a good candidate for a past Roche lobe overflow (RLOF) episode because of its very short orbital period, P = 2.185 days, and the luminosity classes of both components. Methods: We determined a new orbital solution for the system. We studied the photometric light curves to determine the inclination of the orbit and Roche lobe filling factors of both stars. Using phase-resolved spectroscopy, we performed the disentangling of the optical spectra of the two stars. We then analysed the reconstructed primary and secondary spectra with the CMFGEN model atmosphere code to determine stellar parameters, such as the effective temperatures and surface gravities, and to constrain the chemical composition of the components. Results: We confirm the apparent low stellar masses and radii reported in previous studies. We also find a strong overabundance in nitrogen and a strong carbon and oxygen depletion in both primary and secondary atmospheres, together with a strong enrichment in helium of the primary star. Conclusions: We propose several possible evolutionary pathways through a RLOF process to explain the current parameters of the system. We confirm that the system is apparently in overcontact configuration and has lost a significant portion of its mass to its surroundings. We suggest that some of the discrepancies between the spectroscopic and photometric properties of LSS 3074 could stem from the impact of a strong radiation pressure of the primary. Based on observations collected at the European Southern Observatory (La Silla, Chile) and the Cerro Tololo Inter

Determination of Equine Cytochrome c Backbone Amide Hydrogen/Deuterium Exchange Rates by Mass Spectrometry Using a Wider Time Window and Isotope Envelope.

Science.gov (United States)

Hamuro, Yoshitomo

2017-03-01

A new strategy to analyze amide hydrogen/deuterium exchange mass spectrometry (HDX-MS) data is proposed, utilizing a wider time window and isotope envelope analysis of each peptide. While most current scientific reports present HDX-MS data as a set of time-dependent deuteration levels of peptides, the ideal HDX-MS data presentation is a complete set of backbone amide hydrogen exchange rates. The ideal data set can provide single amide resolution, coverage of all exchange events, and the open/close ratio of each amide hydrogen in EX2 mechanism. Toward this goal, a typical HDX-MS protocol was modified in two aspects: measurement of a wider time window in HDX-MS experiments and deconvolution of isotope envelope of each peptide. Measurement of a wider time window enabled the observation of deuterium incorporation of most backbone amide hydrogens. Analysis of the isotope envelope instead of centroid value provides the deuterium distribution instead of the sum of deuteration levels in each peptide. A one-step, global-fitting algorithm optimized exchange rate and deuterium retention during the analysis of each amide hydrogen by fitting the deuterated isotope envelopes at all time points of all peptides in a region. Application of this strategy to cytochrome c yielded 97 out of 100 amide hydrogen exchange rates. A set of exchange rates determined by this approach is more appropriate for a patent or regulatory filing of a biopharmaceutical than a set of peptide deuteration levels obtained by a typical protocol. A wider time window of this method also eliminates false negatives in protein-ligand binding site identification. Graphical Abstract ᅟ.

[Verification of ballast water exchange for international ships anchored in Xiamen Port by CDOM tracer].

Science.gov (United States)

Li, Chao; Zhang, Yan-po; Guo, Wei-dong; Zhu, Yue; Xu, Jing; Deng, Xun

2010-09-01

Fluorescence excitation-emission matrix (EEM) and absorption spectroscopy were applied to study the optical properties of 29 CDOM samples collected from different ballast tanks of nine international route vessels anchored in Xiamen Port between October 2007 and April 2008. The purpose was to examine the feasibility of these spectral properties as a tracer to verify if these vessels follow the mid-ocean ballast water exchange (BWE) regulation. Using parallel factor analysis, four fluorescent components were identified, including two humic-like components (C1: 245, 300/386 nm; C2: 250, 345/458 nm) and two protein-like components (C3: 220, 275/306 nm; C4: 235, 290/345 nm), of which C2 component was the suitable fluorescence verification indicator. The vertical distribution of all fluorescent components in ballast tank was nearly similar indicating that profile-mixing sampling was preferable. Combined use of C2 component, spectral slope ratio (SR) of absorption spectroscopy and salinity may provide reasonable verification if BWE carried out by these nine ships. The results suggested that the combined use of multiple parameters (fluorescence, absorption and salinity) would be much reliable to determine the origin of ballast water, and to provide the technical guarantee for fast examination of ballast water exchange in Chinese ports.

Error analysis of isotope dilution mass spectrometry method with internal standard

International Nuclear Information System (INIS)

Rizhinskii, M.W.; Vitinskii, M.Y.

1989-02-01

The computation algorithms of the normalized isotopic ratios and element concentration by isotope dilution mass spectrometry with internal standard are presented. A procedure based on the Monte-Carlo calculation is proposed for predicting the magnitude of the errors to be expected. The estimation of systematic and random errors is carried out in the case of the certification of uranium and plutonium reference materials as well as for the use of those reference materials in the analysis of irradiated nuclear fuels. 4 refs, 11 figs, 2 tabs

Stream-groundwater exchange and hydrologic turnover at the network scale

Science.gov (United States)

Covino, Tim; McGlynn, Brian; Mallard, John

2011-12-01

The exchange of water between streams and groundwater can influence stream water quality, hydrologic mass balances, and attenuate solute export from watersheds. We used conservative tracer injections (chloride, Cl-) across 10 stream reaches to investigate stream water gains and losses from and to groundwater at larger spatial and temporal scales than typically associated with hyporheic exchanges. We found strong relationships between reach discharge, median tracer velocity, and gross hydrologic loss across a range of stream morphologies and sizes in the 11.4 km2 Bull Trout Watershed of central ID. We implemented these empirical relationships in a numerical network model and simulated stream water gains and losses and subsequent fractional hydrologic turnover across the stream network. We found that stream gains and losses from and to groundwater can influence source water contributions and stream water compositions across stream networks. Quantifying proportional influences of source water contributions from runoff generation locations across the network on stream water composition can provide insight into the internal mechanisms that partially control the hydrologic and biogeochemical signatures observed along networks and at watershed outlets.

Development of isotope dilution-liquid chromatography/mass spectrometry combined with standard addition techniques for the accurate determination of tocopherols in infant formula

Energy Technology Data Exchange (ETDEWEB)

Lee, Joonhee; Jang, Eun-Sil; Kim, Byungjoo, E-mail: byungjoo@kriss.re.kr

2013-07-17

Graphical abstract: -- Highlights: •ID-LC/MS method showed biased results for tocopherols analysis in infant formula. •H/D exchange of deuterated tocopherols in sample preparation was the source of bias. •Standard addition (SA)-ID-LC/MS was developed as an alternative to ID-LC/MS. •Details of calculation and uncertainty evaluation of the SA-IDMS were described. •SA-ID-LC/MS showed a higher-order metrological quality as a reference method. -- Abstract: During the development of isotope dilution-liquid chromatography/mass spectrometry (ID-LC/MS) for tocopherol analysis in infant formula, biased measurement results were observed when deuterium-labeled tocopherols were used as internal standards. It turned out that the biases came from intermolecular H/D exchange and intramolecular H/D scrambling of internal standards in sample preparation processes. Degrees of H/D exchange and scrambling showed considerable dependence on sample matrix. Standard addition-isotope dilution mass spectrometry (SA-IDMS) based on LC/MS was developed in this study to overcome the shortcomings of using deuterium-labeled internal standards while the inherent advantage of isotope dilution techniques is utilized for the accurate recovery correction in sample preparation processes. Details of experimental scheme, calculation equation, and uncertainty evaluation scheme are described in this article. The proposed SA-IDMS method was applied to several infant formula samples to test its validity. The method was proven to have a higher-order metrological quality with providing very accurate and precise measurement results.

77 FR 37082 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

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2012-06-20

... its market share in these products. The Exchange believes this proposed rule change will also serve to... differentiation that exists today at other option exchanges. The Exchange believes it remains an attractive venue... for similar trading strategies. The Exchange operates in a highly competitive market in which market...

Probing color-singlet exchange at D0

International Nuclear Information System (INIS)

Abbott, B.; Abolins, M.; Acharya, B.S.

1997-07-01

We present latest preliminary results on hard color-singlet exchange in proton-antiproton collisions. The fraction of dijet events produced via color-singlet exchange is measured as a function of jet transverse energy, dijet pseudorapidity separation, and proton-antiproton center-of-mass energy. These results are qualitatively consistent with a color-singlet fraction that increases with increasing quark-initiated processes

Heat transfer enhancement for fin-tube heat exchanger using vortex generators

International Nuclear Information System (INIS)

Yoo, Seong Yeon; Park, Dong Seong; Chung, Min Ho; Lee, Sang Yun

2002-01-01

Vortex generators are fabricated on the fin surface of a fin-tube heat exchanger to augment the convective heat transfer. In addition to horseshoe vortices formed naturally around the tube of the fin-tube heat exchanger, longitudinal vortices are artificially created on the fin surface by vortex generators. The purpose of this study is to investigate the local heat transfer phenomena in the fin-tube heat exchangers with and without vortex generators, and to evaluate the effect of vortices on the heat transfer enhancement. Naphthalene sublimation technique is employed to measure local mass transfer coefficients, then analogy equation between heat and mass transfer is used to calculate heat transfer coefficients. Experiments are performed for the model of fin-circular tube heat exchangers with and without vortex generators, and of fin-flat tube heat exchangers with and without vortex generators. Average heat transfer coefficients of fin-flat tube heat exchanger without vortex generator are much lower than those of fin-circular tube heat exchanger. On the other hand, fin-flat tube heat exchanger with vortex generators has much higher heat transfer value than conventional fin-circular tube heat exchanger. At the same time, pressure losses for four types of heat exchanger is measured and compared

Language, culture and international exchange of virtual patients.

Science.gov (United States)

Muntean, Valentin; Calinici, Tudor; Tigan, Stefan; Fors, Uno G H

2013-02-11

Language and cultural differences could be a limiting factor for the international exchange of Virtual Patients (VPs), especially for small countries and languages of limited circulation. Our research evaluated whether it would be feasible to develop a VP based educational program in our Romanian institution, with cases in English and developed in a non-Romanian setting. The participants in the research comprised 4th year Romanian medical students from the Faculty of Medicine in Cluj-Napoca, Romania, with previous training exclusively in Romanian, good English proficiency and no experience with VPs. The students worked on eight VPs in two identical versions, Romanian and English. The first group (2010) of 136 students worked with four VPs developed in Cluj and the second group (2011) of 144 students with four VPs originally developed at an US University. Every student was randomly assigned two different VPs, one in Romanian and another in English. Student activity throughout the case, the diagnosis, therapeutic plan and diagnosis justification were recorded. We also compared student performance on the two VPs versions, Romanian and English and the student performance on the two sets of cases, originally developed in Romania, respectively USA. We found no significant differences between the students' performance on the Romanian vs. English version of VPs. Regarding the students' performance on the two sets of cases, in those originally developed in Romania, respectively in the USA, we found a number of statistically significant differences in the students' activity through the cases. There were no statistically significant differences in the students' ability to reach the correct diagnosis and therapeutic plan. The development of our program with VPs in English would be feasible, cost-effective and in accordance with the globalization of medical education.

Language, culture and international exchange of virtual patients

Directory of Open Access Journals (Sweden)

Muntean Valentin

2013-02-01

Full Text Available Abstract Background Language and cultural differences could be a limiting factor for the international exchange of Virtual Patients (VPs, especially for small countries and languages of limited circulation. Our research evaluated whether it would be feasible to develop a VP based educational program in our Romanian institution, with cases in English and developed in a non-Romanian setting. Method The participants in the research comprised 4th year Romanian medical students from the Faculty of Medicine in Cluj-Napoca, Romania, with previous training exclusively in Romanian, good English proficiency and no experience with VPs. The students worked on eight VPs in two identical versions, Romanian and English. The first group (2010 of 136 students worked with four VPs developed in Cluj and the second group (2011 of 144 students with four VPs originally developed at an US University. Every student was randomly assigned two different VPs, one in Romanian and another in English. Student activity throughout the case, the diagnosis, therapeutic plan and diagnosis justification were recorded. We also compared student performance on the two VPs versions, Romanian and English and the student performance on the two sets of cases, originally developed in Romania, respectively USA. Results We found no significant differences between the students’ performance on the Romanian vs. English version of VPs. Regarding the students’ performance on the two sets of cases, in those originally developed in Romania, respectively in the USA, we found a number of statistically significant differences in the students’ activity through the cases. There were no statistically significant differences in the students’ ability to reach the correct diagnosis and therapeutic plan. Conclusion The development of our program with VPs in English would be feasible, cost-effective and in accordance with the globalization of medical education.

76 FR 58315 - Self-Regulatory Organizations; EDGA Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

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2011-09-20

... Nominating and Governance Committee, the International Securities Exchange's Corporate Governance Committee... Corporate Governance Committee of International Securities Exchange, LLC. Second, EDGA By-Laws currently... reflects the Board's determination that outsourcing the internal audit function to a third-party auditor...

76 FR 58317 - Self-Regulatory Organizations; EDGX Exchange, Inc.; Notice of Filing and Immediate Effectiveness...

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2011-09-20

... Nominating and Governance Committee, the International Securities Exchange's Corporate Governance Committee... Corporate Governance Committee of International Securities Exchange, LLC. Second, EDGX By-Laws currently... reflects the Board's determination that outsourcing the internal audit function to a third-party auditor...

Estimation of air-water gas exchange coefficient in a shallow lagoon based on 222Rn mass balance.

Science.gov (United States)

Cockenpot, S; Claude, C; Radakovitch, O

2015-05-01

The radon-222 mass balance is now commonly used to quantify water fluxes due to Submarine Groundwater Discharge (SGD) in coastal areas. One of the main loss terms of this mass balance, the radon evasion to the atmosphere, is based on empirical equations. This term is generally estimated using one among the many empirical equations describing the gas transfer velocity as a function of wind speed that have been proposed in the literature. These equations were, however, mainly obtained from areas of deep water and may be less appropriate for shallow areas. Here, we calculate the radon mass balance for a windy shallow coastal lagoon (mean depth of 6m and surface area of 1.55*10(8) m(2)) and use these data to estimate the radon loss to the atmosphere and the corresponding gas transfer velocity. We present new equations, adapted to our shallow water body, to express the gas transfer velocity as a function of wind speed at 10 m height (wind range from 2 to 12.5 m/s). When compared with those from the literature, these equations fit particularly well with the one of Kremer et al. (2003). Finally, we emphasize that some gas transfer exchange may always occur, even for conditions without wind. Copyright © 2015 Elsevier Ltd. All rights reserved.

78 FR 77178 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

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2013-12-20

... Members that achieve Tier 2 or higher as shown in the table below. \\4\\ The Exchange offers a rebate in... higher as shown in the table below. \\5\\ The Exchange offers a rebate in Standard and Mini Options for... orders, which are similar to the Exchange's taker rates described above. The Exchange is proposing to...

Heat transfer studies on spiral plate heat exchanger

Directory of Open Access Journals (Sweden)

Rajavel Rangasamy

2008-01-01

Full Text Available In this paper, the heat transfer coefficients in a spiral plate heat exchanger are investigated. The test section consists of a plate of width 0.3150 m, thickness 0.001 m and mean hydraulic diameter of 0.01 m. The mass flow rate of hot water (hot fluid is varying from 0.5 to 0.8 kg/s and the mass flow rate of cold water (cold fluid varies from 0.4 to 0.7 kg/s. Experiments have been conducted by varying the mass flow rate, temperature, and pressure of cold fluid, keeping the mass flow rate of hot fluid constant. The effects of relevant parameters on spiral plate heat exchanger are investigated. The data obtained from the experimental study are compared with the theoretical data. Besides, a new correlation for the Nusselt number which can be used for practical applications is proposed.

Homogeneous cation exchange membrane by radiation grafting

International Nuclear Information System (INIS)

Kolhe, Shailesh M.; G, Agathian; Ashok Kumar

2001-01-01

Preparation of a strong cation exchange membrane by radiation grafting of styrene on to polyethylene (LDPE) film by mutual irradiation technique in the presence of air followed by sulfonation is described. The grafting has been carried out in the presence of air and without any additive. Low dose rate has been seen to facilitate the grafting. Further higher the grafting percentage more is the exchange capacity. The addition of a swelling agent during the sulfonation helped in achieving the high exchange capacity. The TGA-MASS analysis confirmed the grafting and the sulfonation. (author)

Faculty-Exchange Programs Promoting Change: Motivations, Experiences, and Influence of Participants in the Carnegie Mellon University-Portugal Faculty Exchange Program

Science.gov (United States)

Patrício, Maria Teresa; Santos, Patrícia; Loureiro, Paulo Maia; Horta, Hugo

2018-01-01

The international mobility of faculty is increasing worldwide. Although studies have considered the experiences of academics abroad, less is known about faculty-exchange programs with policy objectives. This study helps to fill this gap by analyzing a nationwide structured faculty exchange program established by Carnegie Mellon University and…

The Story of Foreign Trade and Exchange.

Science.gov (United States)

Fan, Cedric

This comic-style booklet is one of a series of educational booklets published by the Federal Reserve Bank of New York. The booklet uses everyday language and lively illustrations to explain the benefits of international trade; the effects of tariffs and quotas; the significance of foreign exchange rates; how the foreign exchange market facilities…

Optimization and application of atmospheric pressure chemical and photoionization hydrogen-deuterium exchange mass spectrometry for speciation of oxygen-containing compounds.

Science.gov (United States)

Acter, Thamina; Kim, Donghwi; Ahmed, Arif; Jin, Jang Mi; Yim, Un Hyuk; Shim, Won Joon; Kim, Young Hwan; Kim, Sunghwan

2016-05-01

This paper presents a detailed investigation of the feasibility of optimized positive and negative atmospheric pressure chemical ionization (APCI) mass spectrometry (MS) and atmospheric pressure photoionization (APPI) MS coupled to hydrogen-deuterium exchange (HDX) for structural assignment of diverse oxygen-containing compounds. The important parameters for optimization of HDX MS were characterized. The optimized techniques employed in the positive and negative modes showed satisfactory HDX product ions for the model compounds when dichloromethane and toluene were employed as a co-solvent in APCI- and APPI-HDX, respectively. The evaluation of the mass spectra obtained from 38 oxygen-containing compounds demonstrated that the extent of the HDX of the ions was structure-dependent. The combination of information provided by different ionization techniques could be used for better speciation of oxygen-containing compounds. For example, (+) APPI-HDX is sensitive to compounds with alcohol, ketone, or aldehyde substituents, while (-) APPI-HDX is sensitive to compounds with carboxylic functional groups. In addition, the compounds with alcohol can be distinguished from other compounds by the presence of exchanged peaks. The combined information was applied to study chemical compositions of degraded oils. The HDX pattern, double bond equivalent (DBE) distribution, and previously reported oxidation products were combined to predict structures of the compounds produced from oxidation of oil. Overall, this study shows that APCI- and APPI-HDX MS are useful experimental techniques that can be applied for the structural analysis of oxygen-containing compounds.

Oxygen isotope exchange on palladium catalysts

International Nuclear Information System (INIS)

Kravchuk, L.S.; Beschetvertnaya, T.I.; Novorodskij, V.G.; Novikova, M.G.; Zaretskij, M.V.; Valieva, S.V.

1983-01-01

Oxygen heteromolecular isotope exchange on unreduced palladium catalysts, distingushing by metal content is studied. Content of 18 O in gaseous phase is eoual to 46%. Calculations of heteroexchange rates are conducted with decrease of the 18 O in the gaseous phase over solid sample. Method of oxygen thermodesorption has been used to establish that palladium, deposited on γ-Al 2 O 3 during exchange process is in oxidized state; in this case strength of Pd-O bond is determined by content dispersity) of the metal. It is shown that significant increase of exchange rate on the samples with Pd >> 0.5 mass.% content can be induced as by side decomposition reaction of its oxide and corresponding dilution of gaseous mixture by ''light'' oxygen so by possibility of exchange with oxygen of PdO phase

Multicomponent liquid ion exchange with chabazite zeolites

International Nuclear Information System (INIS)

Robinson, S.M.; Arnold, W.D. Jr.; Byers, C.W.

1993-10-01

In spite of the increasing commercial use of zeolites for binary and multicomponent sorption, the understanding of the basic mass-transfer processes associated with multicomponent zeolite ion-exchange systems is quite limited. This study was undertaken to evaluate Na-Ca-Mg-Cs-Sr ion exchange from an aqueous solution using a chabazite zeolite. Mass-transfer coefficients and equilibrium equations were determined from experimental batch-reactor data for single and multicomponent systems. The Langmuir isotherm was used to represent the equilibrium relationship for binary systems, and a modified Dubinin-Polyani model was used for the multicomponent systems. The experimental data indicate that diffusion through the microporous zeolite crystals is the primary diffusional resistance. Macropore diffusion also significantly contributes to the mass-transfer resistance. Various mass-transfer models were compared to the experimental data to determine mass-transfer coefficients. Effective diffusivities were obtained which accurately predicted experimental data using a variety of models. Only the model which accounts for micropore and macropore diffusion occurring in series accurately predicted multicomponent data using single-component diffusivities. Liquid and surface diffusion both contribute to macropore diffusion. Surface and micropore diffusivities were determined to be concentration dependent

Modelling the Growth and Volatility in Daily International Mass Tourism to Peru

OpenAIRE

Jose Angelo Divino; Michael McAleer

2009-01-01

Peru is a South American country that is divided into two parts by the Andes Mountains. The rich historical, cultural and geographic diversity has led to the inclusion of ten Peruvian sites on UNESCO’s World Heritage List. For the potential negative impacts of mass tourism on the environment, and hence on future international tourism demand, to be managed appropriately require modelling growth rates and volatility adequately. The paper models the growth rate and volatility (or the variability...

Would Current International Space Station (ISS) Recycling Life Support Systems Save Mass on a Mars Transit?

Science.gov (United States)

Jones, Harry W.

2017-01-01

The oxygen and water are recycled on the International Space Station (ISS) to save the cost of launching their mass into orbit. Usually recycling systems are justified by showing that their launch mass would be much lower than the mass of the oxygen or water they produce. Short missions such as Apollo or space shuttle directly provide stored oxygen and water, since the needed total mass of oxygen and water is much less than that of there cycling equipment. Ten year or longer missions such as the ISS or a future moon base easily save mass by recycling while short missions of days or weeks do not. Mars transit and long Mars surface missions have an intermediate duration, typically one to one and a half years. Some of the current ISS recycling systems would save mass if used on a Mars transit but others would not.

Exchange rate predictability and state-of-the-art models

OpenAIRE

Yeșin, Pınar

2016-01-01

This paper empirically evaluates the predictive performance of the International Monetary Fund's (IMF) exchange rate assessments with respect to future exchange rate movements. The assessments of real trade-weighted exchange rates were conducted from 2006 to 2011, and were based on three state-of-the-art exchange rate models with a medium-term focus which were developed by the IMF. The empirical analysis using 26 advanced and emerging market economy currencies reveals that the "diagnosis" of ...

Exchange-Rate Unification with Black Market Leakages; Russia 1992

OpenAIRE

Linda S. Goldberg

1993-01-01

In 1992 Russia unified the multiple exchange rates that had applied to international transactions. This paper describes the multiple exchange rate system that existed in Russia prior to mid-1992 and undertakes a theoretical exploration of the effects of the exchange rate unification that took place in July 1992. The model developed here allows for leakages between official and black markets and permits flexibility of the exchange rates in both official and parallel currency markets. Within th...

Wherever I may roam: Processes of self-esteem development from adolescence to emerging adulthood in the context of international student exchange.

Science.gov (United States)

Hutteman, Roos; Nestler, Steffen; Wagner, Jenny; Egloff, Boris; Back, Mitja D

2015-05-01

Previous studies on self-esteem development show substantial changes as well as interindividual differences in change from adolescence to young adulthood. However, the processes underlying these developmental trajectories are still not well understood. The aim of the present study was to shed light on the macro- and microprocesses of self-esteem development. We investigated a sample of 876 German high school students (M = 16.0 years at Time 1) participating in an international exchange year. Exchange students provided 3 waves of trait self-esteem data (shortly before they departed, immediately after return, and 1 year later), as well as 9 monthly state measures of self-esteem and social inclusion during their stay abroad. In addition, a control group of high school students who stayed in Germany (N = 714) provided 2 waves of trait self-esteem data. From a macroperspective, results showed an effect of student exchange on trait self-esteem development: Exchange students showed a steeper mean-level increase and a lower rank-order stability compared with control students. Zooming in on the microprocesses underlying these developmental patterns, we found trait changes in exchange students to be mediated by state changes in self-esteem during their exchange. These fluctuations in state self-esteem were found to be predicted by feelings of social inclusion in the host country, and vice versa, providing support for both sociometer and self-broadcasting perspectives on self-esteem dynamics. In sum, our findings emphasize the importance of incorporating a microanalytical approach when investigating self-esteem development by showing that the environment triggers changes in this relatively stable personality trait through changes in states. (c) 2015 APA, all rights reserved).

Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis.

Science.gov (United States)

Devadas, Deepika; Koithan, Thalea; Diestel, Randi; Prank, Ute; Sodeik, Beate; Döhner, Katinka

2014-11-01

Herpes simplex virus 1 (HSV-1) is an alphaherpesvirus that has been reported to infect some epithelial cell types by fusion at the plasma membrane but others by endocytosis. To determine the molecular mechanisms of productive HSV-1 cell entry, we perturbed key endocytosis host factors using specific inhibitors, RNA interference (RNAi), or overexpression of dominant negative proteins and investigated their effects on HSV-1 infection in the permissive epithelial cell lines Vero, HeLa, HEp-2, and PtK2. HSV-1 internalization required neither endosomal acidification nor clathrin- or caveolin-mediated endocytosis. In contrast, HSV-1 gene expression and internalization were significantly reduced after treatment with 5-(N-ethyl-N-isopropyl)amiloride (EIPA). EIPA blocks the activity of Na(+)/H(+) exchangers, which are plasma membrane proteins implicated in all forms of macropinocytosis. HSV-1 internalization furthermore required the function of p21-activated kinases that contribute to macropinosome formation. However, in contrast to some forms of macropinocytosis, HSV-1 did not enlist the activities of protein kinase C (PKC), tyrosine kinases, C-terminal binding protein 1, or dynamin to activate its internalization. These data suggest that HSV-1 depends on Na(+)/H(+) exchangers and p21-activated kinases either for macropinocytosis or for local actin rearrangements required for fusion at the plasma membrane or subsequent passage through the actin cortex underneath the plasma membrane. After initial replication in epithelial cells, herpes simplex viruses (HSVs) establish latent infections in neurons innervating these regions. Upon primary infection and reactivation from latency, HSVs cause many human skin and neurological diseases, particularly in immunocompromised hosts, despite the availability of effective antiviral drugs. Many viruses use macropinocytosis for virus internalization, and many host factors mediating this entry route have been identified, although the

The Research of Foreign Exchange Exposures in Taiwan

OpenAIRE

Chen, Yi Chen

2006-01-01

The research will be mainly focused on the relationship between the stock returns and the fluctuation of foreign exchange rate exposure in Taiwan listed corporations. Due to the environmental limitations and in sufficient resources, if Taiwan inclines to develop international trade, the exchange market plays an important role in the advances of Taiwan's economy. Therefore, the fluctuations of foreign exchange rate must have a substantially impact on the profitability of industries in Taiwan.

Transfer coefficients for plate fin and elliptical tube heat exchangers

International Nuclear Information System (INIS)

Saboya, S.M.; Saboya, F.E.M.

1981-01-01

In order to determine transfer coefficients for plate fin and elliptical tube exchangers, mass transfer experiments have been performed using the naphthalene sublimation technique. By means of the heat-mass transfer analogy, the results can be converted to heat transfer results. The transfer coefficients were compared with those for circular tube exchangers and the comparison revealed no major differences. This is a positive outcome, since the use of elliptical tubes may reduce substantially the pressure drop, without affecting the transfer characteristics.(Author) [pt

Small renal mass biopsy--how, what and when: report from an international consensus panel.

Science.gov (United States)

Tsivian, Matvey; Rampersaud, Edward N; del Pilar Laguna Pes, Maria; Joniau, Steven; Leveillee, Raymond J; Shingleton, William B; Aron, Monish; Kim, Charles Y; DeMarzo, Angelo M; Desai, Mihir M; Meler, James D; Donovan, James F; Klingler, Hans Christoph; Sopko, David R; Madden, John F; Marberger, Michael; Ferrandino, Michael N; Polascik, Thomas J

2014-06-01

To discuss the use of renal mass biopsy (RMB) for small renal masses (SRMs), formulate technical aspects, outline potential pitfalls and provide recommendations for the practicing clinician. The meeting was conducted as an informal consensus process and no scoring system was used to measure the levels of agreement on the different topics. A moderated general discussion was used as the basis for consensus and arising issues were resolved at this point. A consensus was established and lack of agreement to topics or specific items was noted at this point. Recommended biopsy technique: at least two cores, sampling different tumour regions with ultrasonography being the preferred method of image guidance. Pathological interpretation: 'non-diagnostic samples' should refer to insufficient material, inconclusive and normal renal parenchyma. For non-diagnostic samples, a repeat biopsy is recommended. Fine-needle aspiration may provide additional information but cannot substitute for core biopsy. Indications for RMB: biopsy is recommended in most cases except in patients with imaging or clinical characteristics indicative of pathology (syndromes, imaging characteristics) and cases whereby conservative management is not contemplated. RMB is recommended for active surveillance but not for watchful-waiting candidates. We report the results of an international consensus meeting on the use of RMB for SRMs, defining the technique, pathological interpretation and indications. © 2013 The Authors. BJU International © 2013 BJU International.

Internal dust recirculation system for a fluidized bed heat exchanger

Science.gov (United States)

Gamble, Robert L.; Garcia-Mallol, Juan A.

1981-01-01

A fluidized bed heat exchanger in which air is passed through a bed of particulate material containing fuel disposed in a housing. A steam/water natural circulation system is provided in a heat exchange relation to the bed and includes a steam drum disposed adjacent the bed and a tube bank extending between the steam drum and a water drum. The tube bank is located in the path of the effluent gases exiting from the bed and a baffle system is provided to separate the solid particulate matter from the effluent gases. The particulate matter is collected and injected back into the fluidized bed.

Ion Exchange Technology Development in Support of the Urine Processor Assembly Precipitation Prevention Project for the International Space Station

Science.gov (United States)

Mitchell, Julie L.; Broyan, James L.; Pickering, Karen D.; Adam, Niklas; Casteel, Michael; Callahan, Michael; Carrier, Chris

2012-01-01

In support of the Urine Processor Assembly Precipitation Prevention Project (UPA PPP), multiple technologies were explored to prevent CaSO4 2H2O (gypsum) precipitation during the on-orbit distillation process. Gypsum precipitation currently limits the water recovery rate onboard the International Space Station (ISS) to 70% versus the planned 85% target water recovery rate. Due to its ability to remove calcium cations in pretreated augmented urine (PTAU), ion exchange was selected as one of the technologies for further development by the PPP team. A total of 13 ion exchange resins were evaluated in various equilibrium and dynamic column tests with solutions of dissolved gypsum, urine ersatz, PTAU, and PTAU brine at 85% water recovery. While initial evaluations indicated that the Purolite SST60 resin had the highest calcium capacity in PTAU (0.30 meq/mL average), later tests showed that the Dowex G26 and Amberlite FPC12H resins had the highest capacity (0.5 meq/mL average). Testing at the Marshall Spaceflight Center (MSFC) integrates the ion exchange technology with a UPA ground article under flight-like pulsed flow conditions with PTAU. To date, no gypsum precipitation has taken place in any of the initial evaluations.

Measuring the hydrogen/deuterium exchange of proteins at high spatial resolution by mass spectrometry: overcoming gas-phase hydrogen/deuterium scrambling.

Science.gov (United States)

Rand, Kasper D; Zehl, Martin; Jørgensen, Thomas J D

2014-10-21

Proteins are dynamic molecules that exhibit conformational flexibility to function properly. Well-known examples of this are allosteric regulation of protein activity and ligand-induced conformational changes in protein receptors. Detailed knowledge of the conformational properties of proteins is therefore pertinent to both basic and applied research, including drug development, since the majority of drugs target protein receptors and a growing number of drugs introduced to the market are therapeutic peptides or proteins. X-ray crystallography provides a static picture at atomic resolution of the lowest-energy structure of the native ensemble. There is a growing need for sensitive analytical tools to explore all of the significant molecular structures in the conformational landscape of proteins. Hydrogen/deuterium exchange monitored by mass spectrometry (HDX-MS) has recently emerged as a powerful method for characterizing protein conformational dynamics. The basis of this method is the fact that backbone amides in stable hydrogen-bonded structures (e.g., α-helices and β-sheets) are protected against exchange with the aqueous solvent. All protein structures are dynamic, however, and eventually all of the protecting hydrogen bonds will transiently break as the protein--according to thermodynamic principles--cycles through partially unfolded states that correspond to excited free energy levels. As a result, all of the backbone amides will eventually become temporarily solvent-exposed and exchange-competent over time. Consequently, a folded protein in D2O will gradually incorporate deuterium into its backbone amides, and the kinetics of the process can be readily monitored by mass spectrometry. The deuterium uptake kinetics for the intact protein (global exchange kinetics) represents the sum of the exchange kinetics for the individual backbone amides. Local exchange kinetics is typically achieved by using pepsin digestion under quench conditions (i.e., under cold

Optimization of the Single Staggered Wire and Tube Heat Exchanger

Directory of Open Access Journals (Sweden)

Arsana I Made

2016-01-01

Full Text Available Wire and tube heat exchanger consists of a coiled tube, and wire is welded on the two sides of it in normal direction of the tube. Generally,wire and tube heat exchanger uses inline wire arrangement between the two sides, whereas in this study, it used staggered wire arrangement that reduces the restriction of convection heat transfer. This study performed the optimization of single staggered wire and tube heat exchanger to increase the capacity and reduce the mass of the heat exchanger. Optimization was conducted with the Hooke-Jeeves method, which aims to optimize the geometry of the heat exchanger, especially on the diameter (dw and the distance between wires (pw. The model developed to present heat transfer correlations on single staggered wire and tube heat exchanger was valid. The maximum optimization factor obtained when the diameter wire was 0.9 mm and the distance between wires (pw was 11 mm with the fref value = 1.5837. It means that the optimized design only using mass of 59,10 % and could transfer heat about 98,5 % from the basis design.

Experiments and simulations on heat exchangers in thermoelectric generator for automotive application

International Nuclear Information System (INIS)

Liu, X.; Deng, Y.D.; Zhang, K.; Xu, M.; Xu, Y.; Su, C.Q.

2014-01-01

In this work, an energy-harvesting system which extracts heat from an automotive exhaust pipe and turns the heat into electricity by using thermoelectric power generators (TEGs) was built. Experiments show that the temperature difference in automotive system is not constant, especially the heat exchanger, which cannot provide the thermoelectric modules (TMs) large amount of heat. The thermal performance of different heat exchangers in exhaust-based TEGs is studied in this work, and the thermal characteristics of heat exchangers with different internal structures and thickness are discussed, to obtain higher interface temperature and thermal uniformity. Following computational fluid dynamics simulations, infrared experiments and output power testing system are carried out on a high-performance production engine with a dynamometer. Results show that a plate-shaped heat exchanger with chaos-shaped internal structure and thickness of 5 mm achieves a relatively ideal thermal performance, which is practically useful to enhance the thermal performance of the TEG, and larger total output power can be thus obtained. - Graphical abstract: The thermal and electrical characteristics of different heat exchangers of automotive exhaust-based thermoelectric generator are discussed, to obtain higher interface temperature and thermal uniformity. - Highlights: • Different internal structures and thickness of heat exchangers were proposed. • Power output testing system of the two heat exchangers was characterized. • Chaos-shaped heat exchanger (5 mm thickness) shows better performance

Application of metal foam heat exchangers for a high-performance liquefied natural gas regasification system

International Nuclear Information System (INIS)

Kim, Dae Yeon; Sung, Tae Hong; Kim, Kyung Chun

2016-01-01

The intermediate fluid vaporizer has wide applications in the regasification of LNG (liquefied natural gas). The heat exchanger performance is one of the main contributors to the thermodynamic and cost effectiveness of the entire LNG regasification system. Within the paper, the authors discuss a new concept for a compact heat exchanger with a micro-cellular structure medium to minimize volume and mass and to increase thermal efficiency. Numerical calculations have been conducted to design a metal-foam filled plate heat exchanger and a shell-and-tube heat exchanger using published experimental correlations. The geometry of both heat exchangers was optimized using the conditions of thermolators in LNG regasification systems. The heat transfer and pressure drop performance was predicted to compare the heat exchangers. The results show that the metal-foam plate heat exchanger has the best performance at different channel heights and mass flow rates of fluid. In the optimized configurations, the metal-foam plate heat exchanger has a higher heat transfer rate and lower pressure drop than the shell-and-tube heat exchanger as the mass flow rate of natural gas is increased. - Highlights: • A metal foam heat exchanger is proposed for LNG regasification system. • Comparison was made with a shell and tube heat exchanger. • Heat transfer and pressure drop characteristics were estimated. • The geometry of both heat exchangers is optimized for thermolators. • It can be used as a compact and high performance thermolators.

Equilibrium exchange rate assessment in Serbia using the IMF external sustainability approach

Directory of Open Access Journals (Sweden)

Pažun Brankica

2014-01-01

Full Text Available The exchange rate has always been a topical issue, particularly in the last two decades, at the time of strong world economy globalisation, as well as liberalization of international flows of goods, services and factors of production, which has resulted in stronger trade and financial integration. There has been a rise in the share of trade in world GDP. Growing developing countries contribute significantly to this growth, which is evident from the data that show increase of their share in world trade , as well as their importance in international capital flows. One of the most important concepts in open macroeconomics is the equilibrium real exchange rate - ERER. Deviations of the real exchange rate are considered to be the cause of the loss of competitiveness and economic slowdown, as well as possible currency crisis (overvaluation and undervaluation. Disadvantages of traditional concepts in exchange rate assessment which are very often reflected in unsuccessful empirical results, motivate experts to seek alternative models to assist in equilibrium exchange rate analysis. This paper aims to present one of three complementary methodologies used by the International Monetary Fund, for the equilibrium real exchange rate assessment in Serbia, as well as the deviation of the real exchange rate from its (estimated equilibrium, that is external sustainability approach.

Survey report of FY 1997 on the global environmental industry technology development promotion project. International research exchange project; 1997 nendo chosa hokokusho. Chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo (kokusai kenkyu koryu jigyo)

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

Exchange of personnel among foreign research organizations is significant for promoting research and development to create new research fields and to build new technological systems for the purpose of solving global environmental problems. For this purpose, researchers were sent/invited to/from international conferences and international symposiums related to global environmental technology and exchange of personnel with major foreign research organizations and universities was conducted under the cooperation of RITE and RITE-related researchers and related academic societies. Based on short-term invitation and sending of researchers as well as the feasibility study of researcher exchange, researchers were sent/invited on long- and mid-terms. As a result, exchange of personnel engaged in the latest research in Japan and overseas could be promoted. It was found that various researches are being conducted abroad in basic areas of global environmental technology. Since they are closely related to the research and development of industrial technology contributing to global environmental preservation promoted by RITE, it is important to establish a more efficient exchange system of researchers in the future. 91 refs., 38 figs., 14 tabs.

INFX GUIDE: DEPARTMENT OF ENERGY BILATERAL AGREEMENTS FOR COOPERATION IN THE FIELD OF RADIOACTIVE WASTE MANAGEMENT (INFX: INTERNATIONAL INFORMATION EXCHANGE)

Energy Technology Data Exchange (ETDEWEB)

Harman, K. M.; Lakey, L. T.; Leigh, I. W.; Jeffs, A. G.

1985-07-01

As the U. S. Department of Energy (DOE) and DOE contractors have increased the magnitude and scope of their cooperative activities with other nations in the nuclear fuel cycle and waste management field, a need has developed for ready sources of information concerning foreign waste management programs, DOE technology exchange policies, bilateral fuel cycle and waste management agreements and plans and activities to implement those agreements. The INFX (International InLormation E~change) Guide is one of a series of documents that have been prepared to provide that information. The INFX Guide has been compiled under the charter of PNL's International Support Office (IPSO) to maintain for DOE a center to collect, organize, evaluate and disseminate information on foreign and international radioactive waste management programs. Because the information in this document is constantly subject to change, the document is assembled in loose-leaf form to accommodate frequent updates.

Mass spectrometers in medicine

International Nuclear Information System (INIS)

Bushman, J.A.

1975-01-01

This paper describes how the mass spectrometer enables true lung function, namely the exchange of gases between the environment and the organism, to be measured. This has greatly improved the understanding of respiratory disease and the latest generation of respiratory mass spectrometers will do much to increase the application of the technique. (author)

Kinetic theory of oxygen isotopic exchange between minerals and water

Science.gov (United States)

Criss, R.E.; Gregory, R.T.; Taylor, H.P.

1987-01-01

Kinetic and mass conservation equations are used to describe oxygen isotopic exchange between minerals and water in "closed" and open hydrothermal systems. In cases where n coexisting mineral phases having different reaction rates are present, the exchange process is described by a system of n + 1 simultaneous differential equations consisting of n pseudo first-order rate equations and a conservation of mass equation. The simultaneous solutions to these equations generate curved exchange trajectories on ??-?? plots. Families of such trajectories generated under conditions allowing for different fluid mole fractions, different fluid isotopic compositions, or different fluid flow rates are connected by positive-sloped isochronous lines. These isochrons reproduce the effects observed in hydrothermally exchanged mineral pairs including 1) steep positive slopes, 2) common reversals in the measured fractionation factors (??), and 3) measured fractionations that are highly variable over short distances where no thermal gradient can be geologically demonstrated. ?? 1987.

Fibrinogen Reduction During Selective Plasma Exchange due to Membrane Fouling.

Science.gov (United States)

Ohkubo, Atsushi; Okado, Tomokazu; Miyamoto, Satoko; Hashimoto, Yurie; Komori, Shigeto; Yamamoto, Motoki; Maeda, Takuma; Itagaki, Ayako; Yamamoto, Hiroko; Seshima, Hiroshi; Kurashima, Naoki; Iimori, Soichiro; Naito, Shotaro; Sohara, Eisei; Uchida, Shinichi; Rai, Tatemitsu

2017-06-01

Fibrinogen is substantially reduced by most plasmapheresis modalities but retained in selective plasma exchange using Evacure EC-4A10 (EC-4A). Although EC-4A's fibrinogen sieving coefficient is 0, a session of selective plasma exchange reduced fibrinogen by approximately 19%. Here, we investigated sieving coefficient in five patients. When the mean processed plasma volume was 1.15 × plasma volume, the mean reduction of fibrinogen during selective plasma exchange was approximately 15%. Fibrinogen sieving coefficient was 0 when the processed plasma volume was 1.0 L, increasing to 0.07 when the processed plasma volume was 3.0 L, with a mean of 0.03 during selective plasma exchange. When fibrinogen sieving coefficient was 0, selective plasma exchange reduced fibrinogen by approximately 10%. Scanning electron microscopy images revealed internal fouling of EC-4A's hollow fiber membrane by substances such as fibrinogen fibrils. Thus, fibrinogen reduction by selective plasma exchange may be predominantly caused by membrane fouling rather than filtration. © 2017 International Society for Apheresis, Japanese Society for Apheresis, and Japanese Society for Dialysis Therapy.

Using a Spectral Method to Evaluate Hyporheic Exchange and its Effect on Reach Scale Nitrate Removal.

Science.gov (United States)

Moren, I.; Worman, A. L. E.; Riml, J.

2017-12-01

Previous studies have shown that hyporheic exchange processes can be of great importance for the transport, retention and mass removal of nutrients in streams. Specifically, the flow of surface water through the hyporheic zone enhances redox-sensitive reactions such as coupled nitrification-denitrification. This self-cleaning capacity of streams can be utilized in stream restoration projects aiming to improve water quality by reconstructing the geomorphology of the streams. To optimize the effect of restoration actions we need quantitative understanding of the linkage between stream geomorphology, hyporheic exchange processes and the desired water quality targets. Here we propose an analytical, spectral methodology to evaluate how different stream geomorphologies induce hyporheic exchange on a wide range of spatial and temporal scales. Measurements of streambed topographies and surface water profiles from agricultural streams were used to calculate the average hyporheic exchange velocity and residence times and the result was compared with in-stream tracer test. Furthermore, the hyporheic exchange induced by steps in the surface water profile was derived as a comparison of the theoretical capacity of the system. Based on differences in hyporheic exchange, the mass removal of nitrate could be derived for the different geomorphologies. The maximum nitrate mass removal was found to be related to a specific Damkhöler number, which reflects that the mass removal can be either reaction or transport controlled. Therefore, although hyporheic exchange induced by steps in the surface water profile was generally larger than the hyporheic exchange in the observed natural reaches, this would not necessarily lead a larger nitrate mass removal provided that the hyporheic residence times are not long enough to facilitate denitrification processes. The study illustrates the importance to investigate a stream thoroughly before any remediation actions are implemented, specifically

Dynamics of urokinase receptor interaction with Peptide antagonists studied by amide hydrogen exchange and mass spectrometry

DEFF Research Database (Denmark)

Jørgensen, Thomas J D; Gårdsvoll, Henrik; Danø, Keld

2004-01-01

Using amide hydrogen exchange combined with electrospray ionization mass spectrometry, we have in this study determined the number of amide hydrogens on several peptides that become solvent-inaccessible as a result of their high-affinity interaction with the urokinase-type plasminogen activator...... receptor (uPAR). These experiments reveal that at least six out of eight amide hydrogens in a synthetic nine-mer peptide antagonist (AE105) become sequestered upon engagement in uPAR binding. Various uPAR mutants with decreased affinity for this peptide antagonist gave similar results, thereby indicating...... that deletion of the favorable interactions involving the side chains of these residues in uPAR does not affect the number of hydrogen bonds established by the main chain of the peptide ligand. The isolated growth factor-like domain (GFD) of the cognate serine protease ligand for uPAR showed 11 protected amide...

Exchange rate determination and the flaws of mainstream monetary theory

Directory of Open Access Journals (Sweden)

HEINER FLASSBECK

2018-03-01

Full Text Available ABSTRACT Developing countries in general need flexibility and a sufficient number of instruments to prevent excessive volatility. Evidence does not support the orthodox belief that, with free floating, international financial markets will perform that role by smoothly adjusting exchange rates to their “equilibrium” level. In reality, exchange rates under a floating regime have proved to be highly unstable, leading to long spells of misalignment. The experience with hard pegs has not been satisfactory either: the exchange rate could not be corrected in cases of external shocks or misalignment. Given this experience, “intermediate” regimes are preferable when there is instability in international financial markets.

78 FR 66798 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Instituting...

Science.gov (United States)

2013-11-06

... Exchange expresses its view that manipulation of the Index would be very difficult, particularly around the...'' to mean an index designed to be representative of a stock market as a whole or of a range of... market manipulation. The Exchange believes that the same reasoning applies to options on the Index since...

77 FR 33543 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Science.gov (United States)

2012-06-06

... risk management strategies and decisions. However, due to limitations imposed by ISE's rules, the... risk management purposes. 2. Statutory Basis The Exchange believes that the proposed rule change is... strategies on the Exchange. The Exchange believes that this precision is increasingly necessary, and in fact...

78 FR 45590 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2013-07-29

... recently increased as a result of the Exchange's changing the way Priority Customer and Professional... Exchange recently increased as a result of the Exchange's changing the way Priority Customer and..., and all written communications relating to the proposed rule change between the Commission and any...

Proton exchange membrane fuel cells

CERN Document Server

Qi, Zhigang

2013-01-01

Preface Proton Exchange Membrane Fuel CellsFuel CellsTypes of Fuel CellsAdvantages of Fuel CellsProton Exchange Membrane Fuel CellsMembraneCatalystCatalyst LayerGas Diffusion MediumMicroporous LayerMembrane Electrode AssemblyPlateSingle CellStackSystemCell Voltage Monitoring Module (CVM)Fuel Supply Module (FSM)Air Supply Module (ASM)Exhaust Management Module (EMM)Heat Management Module (HMM)Water Management Module (WMM)Internal Power Supply Module (IPM)Power Conditioning Module (PCM)Communications Module (COM)Controls Module (CM)SummaryThermodynamics and KineticsTheoretical EfficiencyVoltagePo

Global Climate Exchange: Peer collaboration in a “Global classroom”

OpenAIRE

Korsager, Majken; Jorde, Doris; Slotta, Jim

2014-01-01

This paper reports on student peer collaboration in an online environment in an international shared curriculum, the Global Climate Exchange. Four cohorts of students (age 16 -19) from Canada, China, Norway and Sweden (n=157) were engaged in four wiki-based activities where they collaborated with peers locally and internationally. Previously, impact from Global Climate Exchange on students’ conceptual understanding was analysed, indicating a positive impact which might be explained by the amo...

The Estimation of the Equilibrium Real Exchange Rate for Romania

OpenAIRE

Bogdan Andrei Dumitrescu; Vasile Dedu

2009-01-01

This paper aims to estimate the equilibrium real exchange rate for Romania, respectively the real exchange rate consistent with the macroeconomic balance, which is achieved when the economy is operating at full employment and low inflation (internal balance) and has a current account that is sustainable (external balance). This equilibrium real exchange rate is very important for an economy because deviations of the real exchange rate from its equilibrium value can affect the competitiveness ...

26 CFR 1.6045-1T - Returns of information of brokers and barter exchanges (temporary).

Science.gov (United States)

2010-04-01

... 26 Internal Revenue 13 2010-04-01 2010-04-01 false Returns of information of brokers and barter exchanges (temporary). 1.6045-1T Section 1.6045-1T Internal Revenue INTERNAL REVENUE SERVICE, DEPARTMENT OF... of information of brokers and barter exchanges (temporary). (a)-(k) [Reserved] For further guidance...

Effect Of Particle Size Of Zeolite On The Mass Transfer Coefficient Of Strontium In The Radioactive Waste Ion-Exchange Process

International Nuclear Information System (INIS)

Dewi-Susilowati; Suyitno

1998-01-01

This research is aimed for finding out the volumetric mass transfer coefficient of the zeolite particle, ks. The experiment has been conducted using an ion exchange column. The column diameter and length are 4.2 cm and 28 cm, respectively. The experiments have been conducted by flowing in the feed to the ion-exchange column containing zeolite with the varied particle diameters, I.e. 20, 40, 60, 80 and 100 mesh. The feed concentrations of Sr(NO 3 ) 2 , have been varied, I.e. 100, 250, 450, 550 and 650 ppm, and so have been the flow rates, I.e/ 35, 49, 70, 90 and 105 ml/minute. Samples of the effluents have been taken at certain series of time and subjected to analysis using an Atomic Absorption Spectrophotometer. The analytical data obtained have shown that the mass transfer coefficient of the zeolite particle is predominantly affected by the zeolite structure, in particular is effected by the number of AI atoms that hold the K ions. The analytical result from the above parameters has been presented in the forms of several groups of dimensionless number. The equations obtained are: (k L *dp)/D L 18.902(Re) 0 ,378 (dp/D) 0 ,6972(Co * ) 0 ,2667 with a mean error of 7.26%; k S 2240.268(dp/D) 1 .553; and each of them is valid in range of: Re: 0.182 - 0.856; dp/D: 0.004 - 0.022; Co * : 9.5408x10 - 5 - 6.2827x10 - 4

78 FR 62901 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2013-10-22

... per contract from its prior rate of $0.05 per contract. See Securities Exchange Act Release No. 69768... similar products.\\13\\ \\13\\ At least one other exchange currently trades foreign currency options. While... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-70647; File No. SR-ISE-2013-50] Self-Regulatory...

Fouling detection in heat exchangers by Takagi-Sugeno observers

International Nuclear Information System (INIS)

Delrot, Sabrina

2012-01-01

The phenomenon of fouling in heat exchangers is currently an important topic. Indeed, the fouling is a costly issue that increases the energy loss (directly or indirectly through an over-sizing of the equipment), and therefore increases the water consumption. As a side effect, fouling increases CO 2 consumption that leads to environmental consequences. Fouling can be detected either on local scale, using expensive and specific sensors or on global scale. Global estimation of fouling can be done by measuring the variation of the mass of the exchanger, or by estimating the efficiency of the exchanger through the transfer coefficient. These two methods require very restricting conditions: a powered exchanger to measure mass variation and a steady state exchanger to estimate the efficiency. The work introduced in this thesis deals with the development of non-linear observers that detect fouling early enough to start an efficient cleaning process. As a beginning, a finite element model of a counter current tubular exchanger was proposed. Then three approaches, based on non-linear Takagi-Sugeno observers, were suggested to detect early fouling in heat exchangers. First approach consisted in a set of observers that estimated the parameters of fouling effect through an interpolation method. The second approach proposed a polynomial Takagi-Sugeno observer, using the theory of sums of squares. Finally, a observer of Takagi-Sugeno type with unknown inputs was developed. As a conclusion, a comparison between those different methods was done. (author)

He II Heat Exchanger Test Unit for the LHC Inner Triplet

CERN Document Server

Blanco-Viñuela, E; Huang, Y; Nicol, T H; Peterson, T; Van Weelderen, R

2002-01-01

The Inner Triplet Heat Exchanger Test Unit (IT-HXTU) is a 30-m long thermal model designed at Fermilab, built in US industry, fully automated and tested at CERN as part of the US LHC program to develop the LHC Interaction Region quadrupole system. The cooling scheme of the IT-HXTU is based on heat exchange between stagnant pressurized He II in the magnet cold mass and saturated He II (two-phase) flowing in a heat exchanger located outside of and parallel to the cold mass. The purposes of this test are, among others, to validate the proposed cooling scheme and to define an optimal control strategy to be implemented in the future LHC accelerator. This paper discusses the results for the heat exchanger test runs and emphasizes the thermal and hydraulic behavior of He II for the inner triplet cooling scheme.

Foreign exchange transaction exposure of enterprises in Serbia

Directory of Open Access Journals (Sweden)

Bogićević Jasmina

2016-01-01

Full Text Available Enterprises involved in international business face transaction exposure to foreign exchange risk. This type of exposure occurs when an enterprise trades, borrows, or lеnds in foreign currency. Transaction exposure has a direct effect on an enterprise’s financial position and profitability. It is one of the three forms of exposure to exchange rate fluctuations, the other two being translation exposure and operating exposure. The aim of this paper is to assess the transaction exposure of enterprises in Serbia operating internationally. In addition to identifying and measuring transaction exposure, this paper explores the practical importance that enterprises in Serbia attach to management of this type of foreign exchange risk. We do not find significant differences between domestic and foreign enterprises in their choice of the type of foreign exchange risk exposure to manage. Although transaction exposure is the most managed type of foreign exchange risk, research has shown that, compared to foreign businesses, Serbian enterprises do not use sufficient protective measures to minimize the negative impact of this type of exposure on their cash flows and profitability. We expected that there would be a statistically significant dependence between the volume of enterprises’ foreign currency transactions and the level of applied transaction exposure management practices. However, the results of our research, based on a sample of enterprises in Serbia operating internationally, show that transaction exposure management practices can be influenced by factors other than the level of an enterprise’s foreign currency transactions, such as the enterprise’s country of origin.

Back-exchange: a novel approach to quantifying oxygen diffusion and surface exchange in ambient atmospheres.

Science.gov (United States)

Cooper, Samuel J; Niania, Mathew; Hoffmann, Franca; Kilner, John A

2017-05-17

A novel two-step Isotopic Exchange (IE) technique has been developed to investigate the influence of oxygen containing components of ambient air (such as H 2 O and CO 2 ) on the effective surface exchange coefficient (k*) of a common mixed ionic electronic conductor material. The two step 'back-exchange' technique was used to introduce a tracer diffusion profile, which was subsequently measured using Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS). The isotopic fraction of oxygen in a dense sample as a function of distance from the surface, before and after the second exchange step, could then be used to determine the surface exchange coefficient in each atmosphere. A new analytical solution was found to the diffusion equation in a semi-infinite domain with a variable surface exchange boundary, for the special case where D* and k* are constant for all exchange steps. This solution validated the results of a numerical, Crank-Nicolson type finite-difference simulation, which was used to extract the parameters from the experimental data. When modelling electrodes, D* and k* are important input parameters, which significantly impact performance. In this study La 0.6 Sr 0.4 Co 0.2 Fe 0.8 O 3-δ (LSCF6428) was investigated and it was found that the rate of exchange was increased by around 250% in ambient air compared to high purity oxygen at the same pO 2 . The three experiments performed in this study were used to validate the back-exchange approach and show its utility.

75 FR 1674 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2010-01-12

... excessive. The proposed rule change reflects a competitive pricing structure designed to incent market...) (SR-ISE-2009-24). To adjust DECN's pricing model to be more consistent with other exchanges (even though DECN is not an exchange),\\7\\ the Exchange is now proposing to de-link the pricing structures of...

International environment, enterprise environment and energy environment giving different look

Energy Technology Data Exchange (ETDEWEB)

Kubo, Shunsuke

1987-04-01

0he international environment, enterprise environment and energy environment surrounding Japan are changing their looks. In such situation, what Japan should do for the development of the world was discussed. Internationally, in the Western Pacific economical block including Japan and Asian NICs, Japan promotes the international exchange of materials, capital, technology, information and people, and creates various international public properties. Enterprisers should have global mind, and cope with the internationalization, technical innovation and information orientation which are in progress at present through international exchange, interindustrial exchange, industry-university-government exchange and so on. In the aspect of energy environment, Japan carries out the technical development of energy conservation, energy, creation and the exploration of energy resources, in this way, contributes to the stabilization of energy in the world. (3 figs, 1 tab)

76 FR 20754 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2011-04-13

... members for potential participation and/or price improvement. \\9\\ A Complex Order is defined in Exchange...\\ An order means a commitment to buy or sell securities as defined in Exchange Rule 715. The proposed... applies.\\20\\ Both the Phlx and the CBOE fees are in essence fees charged by those exchanges for services...

78 FR 56253 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2013-09-12

... number of strike prices being opened above and below the value of the underlying security at about the... the Exchange Act. To the contrary, the Exchange believes the proposal is pro-competitive. In this... the same manner as other exchanges.\\12\\ In sum, the proposed rule change presents no novel issues, and...

Method of burning ion-exchange resin contaminated with radioactivity

International Nuclear Information System (INIS)

Suzuki, Shigenori.

1986-01-01

Purpose: To process spent ion exchange resins to reduce their volume, without increasing the load on a off-gas system and in a stable state and at the same time not leaving any uncombusted portions. Method: The water slurries of the ion exchange resins contaminated with radioactive materials is dehydrated or dry combusted to reduce the water content. A binder is then added to solidify the ion exchange resin. The solidified ion exchange resins are then combusted in a furnace. This prevents the ion exchange resin from being dispersed by air and combustion gases. Furthermore, the solidified ion exchange resins in the form of small pellets burn from the surface inwards. Moreover the binder is carbonized by the combustion heat and promotes combustion to convert the ion exchange resins into a solid mass, making sure that no uncombusted portion is left. (Takahashi, M.)

77 FR 16304 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2012-03-20

... pricing that reduces rates for ISE Market Makers based on the level of business they bring to the Exchange.\\15\\ This proposed rule change targets a particular segment in which the Exchange seeks to attract... specific FX Options which has its own pricing. See ISE Schedule of Fees. \\15\\ The Exchange currently has a...

Academic, Personal, Social and Vocational Needs of International and Exchange Students at the University of Puerto Rico, Río Piedras Campus

OpenAIRE

Ángel A Villafañe-Santiago; Carol Y Irizarry-Robles; Robinson A Vázquez-Ramos

2011-01-01

The purpose of this study was to identify the needs of a sample of the international and exchange students staying at the North Tower Residence of the University of Puerto Rico, Río Piedras Campus. Social and demographic data, as well as the academic, vocational, and social/personal needs were explored with the purpose of gathering relevant information and submitting recommendations to universities serving this student population. Findings revealed particular needs in the academic, voc...

Television Traffic: A One-Way Street? A Survey and Analysis of the International Flow of Television Programme Material. Reports and Papers on Mass Communication No. 70.

Science.gov (United States)

Nordenstreng, Kaarle; Varis, Tapio

An international inventory was made to determine the composition of television programs, particularly from the point of view of program material exported to a country outside. A survey was also made of the international networks for sales and exchanges of program material for broadcast. A report of these studies includes the scope and methods of…

Report on International Symposium for the Promotion of APEC Environmental Technology Exchange and Experts; APEC kankyogijutsu koryusokushin kokusai shinpojium jisshi hokokusho

Energy Technology Data Exchange (ETDEWEB)

NONE

2001-03-01

The above event took place at Nagoya City, Japan, on December 5, 2000. Taken up were the response of developing nations to the problem of environmental protection, their needs for environmental technologies, examples of the transfer of environmental technologies carried out by Japan's environment related businesses or organizations, introduction of technologies Japan was able to present, and so forth. Introduced also were the current state and future outlook of such activities as the exchange of environmental technologies and business through the utilization of the virtual center for APEC (Asia-Pacific Economic Cooperation Conference) environmental technology exchange now in service, and so forth. At the symposium, a keynote address entitled Toward the Realization of Sustainable Society was delivered by Professor Yamamoto of the Institute of Industrial Science of the University of Tokyo. Panel discussions were held on the exchange of environmental technologies and business making use of the international network APEC-VC (virtual center) at Session 1, on some front-line cases of environmental technology transfer at Session 2, and on the transfer of technologies useful for developing nations as it ought to be at Session 3. (NEDO)

Energy and Environment. Electric power stock exchange

International Nuclear Information System (INIS)

Fazioli, R.; Antonioli, B.; Beccarello, M.; Da Rin, B.

2000-01-01

In this paper are reported the structural characteristics of electric power stock exchange in the processes liberalization of european electric markets. International experience are also considered [it

Double Taxation, Tax Credits and the Information Exchange Puzzle

OpenAIRE

Wolfgang Eggert

2003-01-01

This paper analyzes the choice of taxes and international information exchange by governments in a capital tax competition model. We explain situations where countries can choose tax rates on tax savings income and exchange information about the domestic savings of foreigners, implying that the decentralized equilibrium is efficient. However, we also identify situations with adverse welfare properties in which information exchange is compatible with zero taxes on capital income. The model hel...

Ion-exchange equilibrium of N-acetyl-D-neuraminic acid on a strong anionic exchanger.

Science.gov (United States)

Wu, Jinglan; Ke, Xu; Zhang, Xudong; Zhuang, Wei; Zhou, Jingwei; Ying, Hanjie

2015-09-15

N-acetyl-D-neuraminic acid (Neu5Ac) is a high value-added product widely applied in the food industry. A suitable equilibrium model is required for purification of Neu5Ac based on ion-exchange chromatography. Hence, the equilibrium uptake of Neu5Ac on a strong anion exchanger, AD-1 was investigated experimentally and theoretically. The uptake of Neu5Ac by the hydroxyl form of the resin occurred primarily by a stoichiometric exchange of Neu5Ac(-) and OH(-). The experimental data showed that the selectivity coefficient for the exchange of Neu5Ac(-) with OH(-) was a non-constant quantity. Subsequently, the Saunders' model, which took into account the dissociation reactions of Neu5Ac and the condition of electroneutrality, was used to correlate the Neu5Ac sorption isotherms at various solution pHs and Neu5Ac concentrations. The model provided an excellent fit to the binary exchange data for Cl(-)/OH(-) and Neu5Ac(-)/OH(-), and an approximate prediction of equilibrium in the ternary system Cl(-)/Neu5Ac(-)/OH(-). This basic information combined with the general mass transfer model could lay the foundation for the prediction of dynamic behavior of fixed bed separation process afterwards. Copyright © 2015 Elsevier Ltd. All rights reserved.

GAS LOSS BY RAM PRESSURE STRIPPING AND INTERNAL FEEDBACK FROM LOW-MASS MILKY WAY SATELLITES

Energy Technology Data Exchange (ETDEWEB)

Emerick, Andrew; Low, Mordecai-Mark Mac [Department of Astronomy, Columbia University, New York, NY (United States); Grcevich, Jana [Department of Astrophysics, American Museum of Natural History, New York, NY (United States); Gatto, Andrea [Max-Planck-Institute für Astrophysik, Garching, bei München (Germany)

2016-08-01

The evolution of dwarf satellites in the Milky Way (MW) is affected by a combination of ram pressure stripping (RPS), tidal stripping, and internal feedback from massive stars. We investigate gas loss processes in the smallest satellites of the MW using three-dimensional, high-resolution, idealized wind tunnel simulations, accounting for gas loss through both ram pressure stripping and expulsion by supernova feedback. Using initial conditions appropriate for a dwarf galaxy like Leo T, we investigate whether or not environmental gas stripping and internal feedback can quench these low-mass galaxies on the expected timescales, shorter than 2 Gyr. We find that supernova feedback contributes negligibly to the stripping rate for these low star formation rate galaxies. However, we also find that RPS is less efficient than expected in the stripping scenarios we consider. Our work suggests that although RPS can eventually completely strip these galaxies, other physics is likely at play to reconcile our computed stripping times with the rapid quenching timescales deduced from observations of low-mass MW dwarf galaxies. We discuss the roles additional physics may play in this scenario, including host-satellite tidal interactions, cored versus cuspy dark matter profiles, reionization, and satellite preprocessing. We conclude that a proper accounting of these physics together is necessary to understand the quenching of low-mass MW satellites.

Water permeation through anion exchange membranes

Science.gov (United States)

Luo, Xiaoyan; Wright, Andrew; Weissbach, Thomas; Holdcroft, Steven

2018-01-01

An understanding of water permeation through solid polymer electrolyte (SPE) membranes is crucial to offset the unbalanced water activity within SPE fuel cells. We examine water permeation through an emerging class of anion exchange membranes, hexamethyl-p-terphenyl poly (dimethylbenzimidazolium) (HMT-PMBI), and compare it against series of membrane thickness for a commercial anion exchange membrane (AEM), Fumapem® FAA-3, and a series of proton exchange membranes, Nafion®. The HMT-PMBI membrane is found to possess higher water permeabilities than Fumapem® FAA-3 and comparable permeability than Nafion (H+). By measuring water permeation through membranes of different thicknesses, we are able to decouple, for the first time, internal and interfacial water permeation resistances through anion exchange membranes. Permeation resistances on liquid/membrane interface is found to be negligible compared to that for vapor/membrane for both series of AEMs. Correspondingly, the resistance of liquid water permeation is found to be one order of magnitude smaller compared to that of vapor water permeation. HMT-PMBI possesses larger effective internal water permeation coefficient than both Fumapem® FAA-3 and Nafion® membranes (60 and 18% larger, respectively). In contrast, the effective interfacial permeation coefficient of HMT-PMBI is found to be similar to Fumapem® (±5%) but smaller than Nafion®(H+) (by 14%).

Research on Heterogeneous Data Exchange based on XML

Science.gov (United States)

Li, Huanqin; Liu, Jinfeng

Integration of multiple data sources is becoming increasingly important for enterprises that cooperate closely with their partners for e-commerce. OLAP enables analysts and decision makers fast access to various materialized views from data warehouses. However, many corporations have internal business applications deployed on different platforms. This paper introduces a model for heterogeneous data exchange based on XML. The system can exchange and share the data among the different sources. The method used to realize the heterogeneous data exchange is given in this paper.

Martingale Regressions for a Continuous Time Model of Exchange Rates

OpenAIRE

Guo, Zi-Yi

2017-01-01

One of the daunting problems in international finance is the weak explanatory power of existing theories of the nominal exchange rates, the so-called “foreign exchange rate determination puzzle”. We propose a continuous-time model to study the impact of order flow on foreign exchange rates. The model is estimated by a newly developed econometric tool based on a time-change sampling from calendar to volatility time. The estimation results indicate that the effect of order flow on exchange rate...

Exchange Rate Expectations, Currency Crises, and the Pricing of American Depositary Receipts

OpenAIRE

Eichler, Stefan

2012-01-01

I.1 Motivation Exchange rates are a key issue in international economics and politics. While the determinants of exchange rates have been extensively studied in previous works, this dissertation contributes to the literature by deriving exchange rate expectations from stock market (ADR) data and analyzing their determinants. This exercise is done for three cases where one has to resort to exchange rate expectations since the national exchange rate is either manipulated by the central bank...

Search for R-Parity Breaking Sneutrino Exchange at LEP

CERN Document Server

Acciarri, M; Aguilar-Benítez, M; Ahlen, S P; Alcaraz, J; Alemanni, G; Allaby, James V; Aloisio, A; Alverson, G; Alviggi, M G; Ambrosi, G; Anderhub, H; Andreev, V P; Angelescu, T; Anselmo, F; Arefev, A; Azemoon, T; Aziz, T; Bagnaia, P; Baksay, L; Banerjee, S; Banerjee, Sw; Banicz, K; Barczyk, A; Barillère, R; Barone, L; Bartalini, P; Baschirotto, A; Basile, M; Battiston, R; Bay, A; Becattini, F; Becker, U; Behner, F; Berdugo, J; Berges, P; Bertucci, B; Betev, B L; Bhattacharya, S; Biasini, M; Biland, A; Bilei, G M; Blaising, J J; Blyth, S C; Bobbink, Gerjan J; Böck, R K; Böhm, A; Boldizsar, L; Borgia, B; Bourilkov, D; Bourquin, Maurice; Braccini, S; Branson, J G; Brigljevic, V; Brock, I C; Buffini, A; Buijs, A; Burger, J D; Burger, W J; Busenitz, J K; Button, A M; Cai, X D; Campanelli, M; Capell, M; Cara Romeo, G; Carlino, G; Cartacci, A M; Casaus, J; Castellini, G; Cavallari, F; Cavallo, N; Cecchi, C; Cerrada-Canales, M; Cesaroni, F; Chamizo-Llatas, M; Chang, Y H; Chaturvedi, U K; Chekanov, S V; Chemarin, M; Chen, A; Chen, G; Chen, G M; Chen, H F; Chen, H S; Chéreau, X J; Chiefari, G; Chien, C Y; Cifarelli, Luisa; Cindolo, F; Civinini, C; Clare, I; Clare, R; Cohn, H O; Coignet, G; Colijn, A P; Colino, N; Commichau, V; Costantini, S; Cotorobai, F; de la Cruz, B; Csilling, Akos; Dai, T S; D'Alessandro, R; De Asmundis, R; Degré, A; Deiters, K; Della Volpe, D; Denes, P; De Notaristefani, F; DiBitonto, Daryl; Diemoz, M; Van Dierendonck, D N; Di Lodovico, F; Dionisi, C; Dittmar, Michael; Dominguez, A; Doria, A; Dova, M T; Duchesneau, D; Duinker, P; Durán, I; Dutta, S; Easo, S; Efremenko, Yu V; El-Mamouni, H; Engler, A; Eppling, F J; Erné, F C; Ernenwein, J P; Extermann, Pierre; Fabre, M; Faccini, R; Falciano, S; Favara, A; Fay, J; Fedin, O; Felcini, Marta; Fenyi, B; Ferguson, T; Ferroni, F; Fesefeldt, H S; Fiandrini, E; Field, J H; Filthaut, Frank; Fisher, P H; Fisk, I; Forconi, G; Fredj, L; Freudenreich, Klaus; Furetta, C; Galaktionov, Yu; Ganguli, S N; García-Abia, P; Gau, S S; Gentile, S; Gheordanescu, N; Giagu, S; Goldfarb, S; Goldstein, J; Gong, Z F; Gougas, Andreas; Gratta, Giorgio; Grünewald, M W; Gupta, V K; Gurtu, A; Gutay, L J; Hartmann, B; Hasan, A; Hatzifotiadou, D; Hebbeker, T; Hervé, A; Van Hoek, W C; Hofer, H; Hong, S J; Hoorani, H; Hou, S R; Hu, G; Innocente, Vincenzo; Jenkes, K; Jin, B N; Jones, L W; de Jong, P; Josa-Mutuberria, I; Kasser, A; Khan, R A; Kamrad, D; Kamyshkov, Yu A; Kapustinsky, J S; Karyotakis, Yu; Kaur, M; Kienzle-Focacci, M N; Kim, D; Kim, D H; Kim, J K; Kim, S C; Kim, Y G; Kinnison, W W; Kirkby, A; Kirkby, D; Kirkby, Jasper; Kiss, D; Kittel, E W; Klimentov, A; König, A C; Kopp, A; Korolko, I; Koutsenko, V F; Krämer, R W; Krenz, W; Kunin, A; Ladrón de Guevara, P; Laktineh, I; Landi, G; Lapoint, C; Lassila-Perini, K M; Laurikainen, P; Lebeau, M; Lebedev, A; Lebrun, P; Lecomte, P; Lecoq, P; Le Coultre, P; Lee, H J; Le Goff, J M; Leiste, R; Leonardi, E; Levchenko, P M; Li Chuan; Lin, C H; Lin, W T; Linde, Frank L; Lista, L; Liu, Z A; Lohmann, W; Longo, E; Lu, W; Lü, Y S; Lübelsmeyer, K; Luci, C; Luckey, D; Luminari, L; Lustermann, W; Ma Wen Gan; Maity, M; Majumder, G; Malgeri, L; Malinin, A; Maña, C; Mangeol, D J J; Mangla, S; Marchesini, P A; Marin, A; Martin, J P; Marzano, F; Massaro, G G G; McNally, D; McNeil, R R; Mele, S; Merola, L; Meschini, M; Metzger, W J; Von der Mey, M; Mi, Y; Mihul, A; Van Mil, A J W; Milcent, H; Mirabelli, G; Mnich, J; Molnár, P; Monteleoni, B; Moore, R; Morganti, S; Moulik, T; Mount, R; Müller, S; Muheim, F; Muijs, A J M; Nahn, S; Napolitano, M; Nessi-Tedaldi, F; Newman, H; Niessen, T; Nippe, A; Nisati, A; Nowak, H; Oh, Yu D; Opitz, H; Organtini, G; Ostonen, R; Palomares, C; Pandoulas, D; Paoletti, S; Paolucci, P; Park, H K; Park, I H; Pascale, G; Passaleva, G; Patricelli, S; Paul, T; Pauluzzi, M; Paus, C; Pauss, Felicitas; Peach, D; Pei, Y J; Pensotti, S; Perret-Gallix, D; Petersen, B; Petrak, S; Pevsner, A; Piccolo, D; Pieri, M; Piroué, P A; Pistolesi, E; Plyaskin, V; Pohl, M; Pozhidaev, V; Postema, H; Produit, N; Prokofev, D; Prokofiev, D O; Rahal-Callot, G; Raja, N; Rancoita, P G; Rattaggi, M; Raven, G; Razis, P A; Read, K; Ren, D; Rescigno, M; Reucroft, S; Van Rhee, T; Riemann, S; Riles, K; Robohm, A; Rodin, J; Roe, B P; Romero, L; Rosier-Lees, S; Rosselet, P; Van Rossum, W; Roth, S; Rubio, Juan Antonio; Ruschmeier, D; Rykaczewski, H; Salicio, J; Sánchez, E; Sanders, M P; Sarakinos, M E; Sarkar, S; Sassowsky, M; Schäfer, C; Shchegelskii, V; Schmidt-Kärst, S; Schmitz, D; Schmitz, P; Scholz, N; Schopper, Herwig Franz; Schotanus, D J; Schwenke, J; Schwering, G; Sciacca, C; Sciarrino, D; Servoli, L; Shevchenko, S; Shivarov, N; Shoutko, V; Shukla, J; Shumilov, E; Shvorob, A V; Siedenburg, T; Son, D; Sopczak, André; Smith, B; Spillantini, P; Steuer, M; Stickland, D P; Stone, A; Stone, H; Stoyanov, B; Strässner, A; Strauch, K; Sudhakar, K; Sultanov, G G; Sun, L Z; Susinno, G F; Suter, H; Swain, J D; Tang, X W; Tauscher, Ludwig; Taylor, L; Ting, C C; Ting, S M; Tonutti, M; Tonwar, S C; Tóth, J; Tully, C; Tuchscherer, H; Tung, K L; Uchida, Y; Ulbricht, J; Uwer, U; Valente, E; Van de Walle, R T; Vesztergombi, G; Vetlitskii, I; Viertel, Gert M; Vivargent, M; Völkert, R; Vogel, H; Vogt, H; Vorobev, I; Vorobyov, A A; Vorvolakos, A; Wadhwa, M; Wallraff, W; Wang, J C; Wang, X L; Wang, Z M; Weber, A; Wittgenstein, F; Wu, S X; Wynhoff, S; Xu, J; Xu, Z Z; Yang, B Z; Yang, C G; Yao, X Y; Ye, J B; Yeh, S C; You, J M; Zalite, A; Zalite, Yu; Zemp, P; Zeng, Y; Zhang, Z; Zhang, Z P; Zhou, B; Zhu, G Y; Zhu, R Y; Zichichi, Antonino; Ziegler, F

1997-01-01

We report on a search for R--parity breaking effects due to supersymmetric tau--sneutrino exchange in the reactions e+e- to e+e- and e+e- to mu+mu- at centre--of--mass energies from 91~{\\GeV} to 172~{\\GeV}, using the L3 detector at LEP. No evidence for deviations from the Standard Model expectations of the measured cross sections and forward--backward asymmetries for these reactions is found. Upper limits for the couplings $\\lambda_{131}$ and $\\lambda_{232}$ for sneutrino masses up to $m_{\\SNT} \\leq 190~\\GeV$ are determined from an analysis of the expected effects due to tau sneutrino exchange.

Cross-border data exchange - a case study on international collaboration gone wrong

Science.gov (United States)

Yanko-Hombach, Valentina

2016-04-01

The subject of ethics in science has become a hot topic recently (Gleick, 2011). As publication pressure on researchers increases and use of the internet allows faster turn-around, the quality of the peer review process has suffered. This presentation describes one case of scientific ethics violation in which the editors of a high-ranking scientific journal improperly permitted publication of a paper that was based upon unethical acquisition of data and failed to acknowledge scientific collaboration and exchange of intellectual property. We will present "Case description" and "Ethical issues" with a hope that our experience draws attention to important ethical issues in international collaborative research, and prevents such misconduct in the future. Since international research involves cooperation and coordination among many people in different disciplines and institutions across national borders, ethical standards should promote values that are essential to integrity and collaborative work, including trust, accountability, mutual respect, and fairness. One lesson to be learned is not to engage in collaboration without a written agreement stating clearly who is responsible for what and how the results of collaborative research are to be shared. This is especially important in cases of international collaborations, particularly those involving smaller or developing nations who often do not have the high-tech facilities of developed nations. There is also need to establish clear regulations regarding co-authorship on papers in which intellectual property and significant financial investment was made to allow the research to proceed. As such, a system of ethics to guide the practice of science from data collection to publication and beyond is timely and much needed to protect the integrity of scientific collaboration. It will keep science moving forward by validating research findings and confirming or raising questions about results. References Benos, D. J., Fabres

Reversible Guest Exchange Mechanisms in Supramolecular Host-GuestAssemblies

Energy Technology Data Exchange (ETDEWEB)

Pluth, Michael D.; Raymond, Kenneth N.

2006-09-01

Synthetic chemists have provided a wide array of supramolecular assemblies able to encapsulate guest molecules. The scope of this tutorial review focuses on supramolecular host molecules capable of reversibly encapsulating polyatomic guests. Much work has been done to determine the mechanism of guest encapsulation and guest release. This review covers common methods of monitoring and characterizing guest exchange such as NMR, UV-VIS, mass spectroscopy, electrochemistry, and calorimetry and also presents representative examples of guest exchange mechanisms. The guest exchange mechanisms of hemicarcerands, cucurbiturils, hydrogen-bonded assemblies, and metal-ligand assemblies are discussed. Special attention is given to systems which exhibit constrictive binding, a motif common in supramolecular guest exchange systems.

Qualitative and quantitative analysis of branches in dextran using high-performance anion exchange chromatography coupled to quadrupole time-of-flight mass spectrometry.

Science.gov (United States)

Yi, Lin; Ouyang, Yilan; Sun, Xue; Xu, Naiyu; Linhardt, Robert J; Zhang, Zhenqing

2015-12-04

Dextran, a family of natural polysaccharides, consists of an α (1→6) linked-glucose main (backbone) chain having a number of branches. The determination of the types and the quantities of branches in dextran is important in understanding its various biological roles. In this study, a hyphenated method using high-performance anion exchange chromatography (HPAEC) in parallel with pulsed amperometric detection (PAD) and mass spectrometry (MS) was applied to qualitative and quantitative analysis of dextran branches. A rotary cation-exchange cartridge array desalter was used for removal of salt from the HPAEC eluent making it MS compatible. MS and MS/MS were used to provide structural information on the enzymatically prepared dextran oligosaccharides. PAD provides quantitative data on the ratio of enzyme-resistant, branched dextran oligosaccharides. Both the types and degree of branching found in a variety of dextrans could be simultaneously determined online using this method. Copyright © 2015 Elsevier B.V. All rights reserved.

Internal Carotid Artery Ectasia: The Value of Imaging Studies Prior to Biopsy of a Retropharyngeal Mass

Directory of Open Access Journals (Sweden)

Kenneth Chan

2010-11-01

Full Text Available The presence of retropharyngeal tissue mass often raises the suspicion of malignancy, especially in elderly patients. This prompts urgent biopsy to investigate tissue histology. We discuss a case where this is contraindicated as the retropharyngeal mass was illustrated by CT scanning and confirmed with MRI to be a tortuous coursing internal carotid artery. An awareness of this unusual anatomical variation and a careful interpretation of imaging studies both at the stage of differential diagnosis and pre-operative screening are essential to avoid damage to important structures, causing unnecessary complications.

Analysis of two-phase flow inter-subchannel mass and momentum exchanges by the two-fluid model approach

Energy Technology Data Exchange (ETDEWEB)

Ninokata, H. [Tokyo Institute of Technology (Japan); Deguchi, A. [ENO Mathematical Analysis, Tokyo (Japan); Kawahara, A. [Kumamoto Univ., Kumamoto (Japan)

1995-09-01

A new void drift model for the subchannel analysis method is presented for the thermohydraulics calculation of two-phase flows in rod bundles where the flow model uses a two-fluid formulation for the conservation of mass, momentum and energy. A void drift model is constructed based on the experimental data obtained in a geometrically simple inter-connected two circular channel test sections using air-water as working fluids. The void drift force is assumed to be an origin of void drift velocity components of the two-phase cross-flow in a gap area between two adjacent rods and to overcome the momentum exchanges at the phase interface and wall-fluid interface. This void drift force is implemented in the cross flow momentum equations. Computational results have been successfully compared to experimental data available including 3x3 rod bundle data.

Internal energy deposition with silicon nanoparticle-assisted laser desorption/ionization (SPALDI) mass spectrometry

Science.gov (United States)

Dagan, Shai; Hua, Yimin; Boday, Dylan J.; Somogyi, Arpad; Wysocki, Ronald J.; Wysocki, Vicki H.

2009-06-01

The use of silicon nanoparticles for laser desorption/ionization (LDI) is a new appealing matrix-less approach for the selective and sensitive mass spectrometry of small molecules in MALDI instruments. Chemically modified silicon nanoparticles (30 nm) were previously found to require very low laser fluence in order to induce efficient LDI, which raised the question of internal energy deposition processes in that system. Here we report a comparative study of internal energy deposition from silicon nanoparticles to previously explored benzylpyridinium (BP) model compounds during LDI experiments. The internal energy deposition in silicon nanoparticle-assisted laser desorption/ionization (SPALDI) with different fluorinated linear chain modifiers (decyl, hexyl and propyl) was compared to LDI from untreated silicon nanoparticles and from the organic matrix, [alpha]-cyano-4-hydroxycinnamic acid (CHCA). The energy deposition to internal vibrational modes was evaluated by molecular ion survival curves and indicated that the ions produced by SPALDI have an internal energy threshold of 2.8-3.7 eV. This is slightly lower than the internal energy induced using the organic CHCA matrix, with similar molecular survival curves as previously reported for LDI off silicon nanowires. However, the internal energy associated with desorption/ionization from the silicon nanoparticles is significantly lower than that reported for desorption/ionization on silicon (DIOS). The measured survival yields in SPALDI gradually decrease with increasing laser fluence, contrary to reported results for silicon nanowires. The effect of modification of the silicon particle surface with semifluorinated linear chain silanes, including fluorinated decyl (C10), fluorinated hexyl (C6) and fluorinated propyl (C3) was explored too. The internal energy deposited increased with a decrease in the length of the modifier alkyl chain. Unmodified silicon particles exhibited the highest analyte internal energy

OECD/NEA International Common Cause Failure Data Exchange (ICDE) project - insights and lessons learnt

International Nuclear Information System (INIS)

Johanson, G.; Kreuser, A.; Pyy, P.; Rasmuson, D.; Werner, W.

2006-01-01

Events initiated by common-cause-failure (CCF) can significantly affect the availability and reliability of nuclear power plant safety systems. In recognition of this, CCF data are systematically collected and analysed in the International Common-Cause Data Exchange (ICDE) Project, which was initiated in August 1994. Since April 1998, the NEA has formally operated the project. Currently eleven countries participate in the project. The ICDE collects all events where two or more identical, redundant components of a group, fulfilling the same function, have failed or were impaired due to a shared cause (ICDE events). Complete CCFs, i. e. failure of all identical, redundant components in the group due to a shared cause are an important subset of the collected data. Currently, data exchange and analysis covers the following components: centrifugal pumps, diesel generators, motor-operated valves, safety and relief valves, check valves, reactor protection system components (level measurement, control rod drives, etc), circuit breakers, and batteries. The main findings of the ICDE reports issued by 2005 show averaged over all components that about two thirds of all complete CCF events involve faulty actions by plant personnel and contractors. The single largest contribution is from faulty testing and maintenance work due to deficient and/or incomplete procedures. Other important causes are insufficient testing and requalification of components or systems after maintenance, repair, modifications or backfitting work, as well as operator errors of commission. The probability that a reported ICDE event is a complete CCF decreases strongly with increasing number of redundant components, demonstrating the effectiveness of redundancy as a powerful defence against CCFs. However, complete CCFs cannot be completely prevented by high redundancy only. (orig.)

International hedging under concurrent risks of input/output prices and exchange rate : The case of Korean oil refinery

Energy Technology Data Exchange (ETDEWEB)

Yun, W C; Kim, S D [Korea Energy Economics Institute, Euiwang (Korea, Republic of)

1997-11-01

This study develops an international hedging model which accounts for the multiple risks of input and output prices and exchange rates. Considering a fixed production technology, we formulize simultaneous minimum variance hedge ratios, which reflects inter correlations among prices. To utilize the dynamic nature of prices, time-varying conditional procedures are specified to estimate the relevant variance and covariance matrix. The time-varying representations of the variance and covariance matrix are statistically appropriate, in general. The separate hedge ratios are similar to the simultaneous hedge ratios for alternative procedures. The ex post hedging effectiveness indicate that there are substantial reduction in the variance of returns for all the procedures. The contribution of foreign currency futures is minimal due to the low correlation between commodities and exchange rates. Based on the traditional definition of hedging effectiveness, the time-varying conditional procedure provide little gain to the hedgers over a constant procedure in terms of the mean and the variance reduction. However, the performance of conditional procedures could be improved by accounting for the potential problems: mis specification problem, inappropriate definition of hedging effectiveness, and conflicts between theoretical derivation and estimation of hedge ratios. (author). 39 refs., 6 tabs.

Protein Internal Dynamics Associated With Pre-System Glass Transition Temperature Endothermic Events: Investigation of Insulin and Human Growth Hormone by Solid State Hydrogen/Deuterium Exchange.

Science.gov (United States)

Fang, Rui; Grobelny, Pawel J; Bogner, Robin H; Pikal, Michael J

2016-11-01

Lyophilized proteins are generally stored below their glass transition temperature (T g ) to maintain long-term stability. Some proteins in the (pure) solid state showed a distinct endotherm at a temperature well below the glass transition, designated as a pre-T g endotherm. The pre-T g endothermic event has been linked with a transition in protein internal mobility. The aim of this study was to investigate the internal dynamics of 2 proteins, insulin and human growth hormone (hGH), both of which exhibit the pre-T g endothermic event with onsets at 50°C-60°C. Solid state hydrogen/deuterium (H/D) exchange of both proteins was characterized by Fourier transform infrared spectroscopy over a temperature range from 30°C to 80°C. A distinct sigmoidal transition in the extent of H/D exchange had a midpoint of 56.1 ± 1.2°C for insulin and 61.7 ± 0.9°C for hGH, suggesting a transition to greater mobility in the protein molecules at these temperatures. The data support the hypothesis that the pre-T g event is related to a transition in internal protein mobility associated with the protein dynamical temperature. Exceeding the protein dynamical temperature is expected to activate protein internal motion and therefore may have stability consequences. Copyright © 2016 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

Design concept for vessels and heat exchangers

International Nuclear Information System (INIS)

Elfmann, W.; Ferrari, L.D.B.

1981-01-01

A design concept for vessels and heat exchangers against internal and external loads resulting from normal operation and accident is shown. A definition and explanation of the operating conditions and stress levels are given. A description of the type of analysis (stress, fatigue, deformation, stability, earthquake and vibration) is presented in detail, also including technical guidelines which are used for the vessels and heat exchangers and their individual structure parts. (Author) [pt

Direct and quantitative characterization of dynamic ligand exchange between coordination-driven self-assembled supramolecular polygons.

Science.gov (United States)

Zheng, Yao-Rong; Stang, Peter J

2009-03-18

The direct observation of dynamic ligand exchange between Pt-N coordination-driven self-assembled supramolecular polygons (triangles and rectangles) has been achieved using stable (1)H/(2)D isotope labeling of the pyridyl donors and electrospray ionization mass spectrometry combined with NMR spectroscopy. Both the thermodynamic and kinetic aspects of such exchange processes have been established on the basis of quantitative mass spectral results. Further investigation has shown that the exchange is highly dependent on experimental conditions such as temperature, solvent, and the counteranions.

Stability of Intercellular Exchange of Biochemical Substances Affected by Variability of Environmental Parameters

Science.gov (United States)

Mihailović, Dragutin T.; Budinčević, Mirko; Balaž, Igor; Mihailović, Anja

Communication between cells is realized by exchange of biochemical substances. Due to internal organization of living systems and variability of external parameters, the exchange is heavily influenced by perturbations of various parameters at almost all stages of the process. Since communication is one of essential processes for functioning of living systems it is of interest to investigate conditions for its stability. Using previously developed simplified model of bacterial communication in a form of coupled difference logistic equations we investigate stability of exchange of signaling molecules under variability of internal and external parameters.

Ion Mobility Spectrometry-Mass Spectrometry Coupled with Gas-Phase Hydrogen/Deuterium Exchange for Metabolomics Analyses

Science.gov (United States)

Maleki, Hossein; Karanji, Ahmad K.; Majuta, Sandra; Maurer, Megan M.; Valentine, Stephen J.

2018-02-01

Ion mobility spectrometry-mass spectrometry (IMS-MS) in combination with gas-phase hydrogen/deuterium exchange (HDX) and collision-induced dissociation (CID) is evaluated as an analytical method for small-molecule standard and mixture characterization. Experiments show that compound ions exhibit unique HDX reactivities that can be used to distinguish different species. Additionally, it is shown that gas-phase HDX kinetics can be exploited to provide even further distinguishing capabilities by using different partial pressures of reagent gas. The relative HDX reactivity of a wide variety of molecules is discussed in light of the various molecular structures. Additionally, hydrogen accessibility scoring (HAS) and HDX kinetics modeling of candidate ( in silico) ion structures is utilized to estimate the relative ion conformer populations giving rise to specific HDX behavior. These data interpretation methods are discussed with a focus on developing predictive tools for HDX behavior. Finally, an example is provided in which ion mobility information is supplemented with HDX reactivity data to aid identification efforts of compounds in a metabolite extract.

Kinetics of the high temperature oxygen exchange reaction on 238PuO2 powder

International Nuclear Information System (INIS)

Whiting, Christofer E.; Du, Miting; Felker, L. Kevin; Wham, Robert M.; Barklay, Chadwick D.; Kramer, Daniel P.

2015-01-01

Oxygen exchange reactions performed on PuO 2 suggest the reaction is influenced by at least three mechanisms: an internal chemical reaction, surface mobility of active species/defects, and surface exchange of gaseous oxygen with lattice oxygen. Activation energies for the surface mobility and internal chemical reaction are presented. Determining which mechanism is dominant appears to be a complex function including at least specific surface area and temperature. Thermal exposure may also impact the oxygen exchange reaction by causing reductions in the specific surface area of PuO 2 . Previous CeO 2 surrogate studies exhibit similar behavior, confirming that CeO 2 is a good qualitative surrogate for PuO 2 , in regards to the oxygen exchange reaction. Comparison of results presented here with previous work on the PuO 2 oxygen exchange reaction allows complexities in the previous work to be explained. These explanations allowed new conclusions to be drawn, many of which confirm the conclusions presented here. - Highlights: • PuO 2 Oxygen exchange kinetics can be influenced by at least 3 different mechanisms. • An internal chemical reaction controls the rate at high temperature and large SSA. • Surface mobility and surface exchange influence rate at lower temperatures and SSA. • Exchange temperatures may alter SSA and make data difficult to interpret.

Exchange Rate Volatility, Its Determinants and Effects on the Manufacturing Sector in Nigeria

OpenAIRE

Chimaobi V. Okolo; Onyinye S. Ugwuanyi; Kenneth A. Okpala

2017-01-01

This study evaluated the effect of exchange rate volatility on the manufacturing sector of Nigeria. The flow and stock market theories of exchange rate determination was adopted considering macroeconomic determinants such as balance of trade, trade openness, and net international investment. Furthermore, the influence of changes in parallel exchange rate, official exchange rate and real effective exchange rate was modeled on the manufacturing sector output. Vector autoregression techniques an...

Geometric optimization of cross-flow heat exchanger based on dynamic controllability

Directory of Open Access Journals (Sweden)

Alotaibi Sorour

2008-01-01

Full Text Available The operation of heat exchangers and other thermal equipments in the face of variable loads is usually controlled by manipulating inlet fluid temperatures or mass flow rates, where the controlled variable is usually one of the output temperatures. The aim of this work is to optimize the geometry of a tube with internal flow of water and an external cross-flow of air, based on its controllability characteristics. Controllability is a useful concept both from theoretical and practical perspective since it tells us if a particular output can be controlled by a particular input. This concept can also provide us with information about the easiest operating condition to control a particular output. A transient model of a tube in cross-flow is developed, where an implicit formulation is used for transient numerical solutions. The aspect ratio of the tube is optimized, subject to volume constraints, based on the optimum operation in terms of controllability. The reported optimized aspect ratio, water mass flow rate and controllability are studied for deferent external properties of the tube.

Promotional operation for developing industrial technologies for global environment in fiscal 1998. International research exchange operation; 1998 nendo chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo. Kokusai kenkyu koryu jigyo

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

With an objective of creating a new scope of study intended of solving global environment problems and structuring a new technical system, exchanges with overseas researchers and research institutions have been carried out subsequent to those in last year. In fiscal 1998, six researchers from different countries were invited to implement joint researches, and two overseas researchers were invited to an international conference on industrial technologies for global environment. In addition, in order to identify trends of research and development in overseas countries, two researchers were sent to universities in Germany and the U.S.A., and three researchers to international conferences and symposiums on the industrial technologies for global environment. It was intended to exchange technological information between overseas researchers and Japanese researchers who are performing the advanced researches on the industrial technologies for global environment, and to proliferate the latest items of technological information. Therefore, seven international seminars have been held, including the '98 Japan-China Global Environment Protection Symposium, 'substance migration and carbon circulation in coral reefs', 'plant bio-technologies in the 21st century', and the Fourth International Forum for Environmental Catalysts. (NEDO)

Promotional operation for developing industrial technologies for global environment in fiscal 1998. International research exchange operation; 1998 nendo chikyu kankyo sangyo gijutsu kaihatsu suishin jigyo. Kokusai kenkyu koryu jigyo

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

With an objective of creating a new scope of study intended of solving global environment problems and structuring a new technical system, exchanges with overseas researchers and research institutions have been carried out subsequent to those in last year. In fiscal 1998, six researchers from different countries were invited to implement joint researches, and two overseas researchers were invited to an international conference on industrial technologies for global environment. In addition, in order to identify trends of research and development in overseas countries, two researchers were sent to universities in Germany and the U.S.A., and three researchers to international conferences and symposiums on the industrial technologies for global environment. It was intended to exchange technological information between overseas researchers and Japanese researchers who are performing the advanced researches on the industrial technologies for global environment, and to proliferate the latest items of technological information. Therefore, seven international seminars have been held, including the '98 Japan-China Global Environment Protection Symposium, 'substance migration and carbon circulation in coral reefs', 'plant bio-technologies in the 21st century', and the Fourth International Forum for Environmental Catalysts. (NEDO)

Supercritical fluid chromatography coupled with in-source atmospheric pressure ionization hydrogen/deuterium exchange mass spectrometry for compound speciation.

Science.gov (United States)

Cho, Yunju; Choi, Man-Ho; Kim, Byungjoo; Kim, Sunghwan

2016-04-29

An experimental setup for the speciation of compounds by hydrogen/deuterium exchange (HDX) with atmospheric pressure ionization while performing chromatographic separation is presented. The proposed experimental setup combines the high performance supercritical fluid chromatography (SFC) system that can be readily used as an inlet for mass spectrometry (MS) and atmospheric pressure photo ionization (APPI) or atmospheric pressure chemical ionization (APCI) HDX. This combination overcomes the limitation of an approach using conventional liquid chromatography (LC) by minimizing the amount of deuterium solvents used for separation. In the SFC separation, supercritical CO2 was used as a major component of the mobile phase, and methanol was used as a minor co-solvent. By using deuterated methanol (CH3OD), AP HDX was achieved during SFC separation. To prove the concept, thirty one nitrogen- and/or oxygen-containing standard compounds were analyzed by SFC-AP HDX MS. The compounds were successfully speciated from the obtained SFC-MS spectra. The exchange ions were observed with as low as 1% of CH3OD in the mobile phase, and separation could be performed within approximately 20min using approximately 0.24 mL of CH3OD. The results showed that SFC separation and APPI/APCI HDX could be successfully performed using the suggested method. Copyright © 2016 Elsevier B.V. All rights reserved.

Methanol exchange dynamics between a temperate cropland soil and the atmosphere

Science.gov (United States)

Bachy, A.; Aubinet, M.; Amelynck, C.; Schoon, N.; Bodson, B.; Moureaux, C.; Delaplace, P.; De Ligne, A.; Heinesch, B.

2018-03-01

Soil methanol (CH3OH) exchange is often considered as several orders of magnitude smaller than plant methanol exchange. However, for some ecosystems, it is significant in regard with plant exchange and worth thus better consideration. Our study sought to gain a better understanding of soil exchange. Methanol flux was measured at the ecosystem scale on a bare agricultural soil over two contrasted periods using the disjunct eddy covariance by mass scanning technique. A proton-transfer-reaction mass spectrometer was used for the methanol ambient mixing ratio measurements. Bi-directional exchange dynamics were observed. Methanol emission occurred under dry and warm conditions and correlated best with soil surface temperature, whereas methanol uptake occurred under wet and mild conditions and correlated well with the methanol ambient concentration. After having tested a physical adsorption-desorption model and by confronting our data with the literature, we propose that the exchange was ruled by both a physical adsorption/desorption mechanism and by a methanol source, which still needs to be identified. The soil emission decreased when the vegetation developed. The reasons for the decrease still need to be determined. Overall, the dynamics observed at our site were similar to those reported by other studies for both cropland and forest ecosystems. The mechanism proposed in our work can thus be possibly applied to other sites or ecosystems. In addition, the methanol exchange rate was in the upper range of the exchange rates reported by other soil studies, suggesting that cropland soils are more important methanol exchangers than those in other ecosystems and should therefore be further investigated.

Charge exchange of solar wind ions in the Comet Halley coma

Science.gov (United States)

Shelley, E. G.; Ing-H. afgoldstein, B. E. AGGOLDSTEIN, R.; Ing-H. afgoldstein, B. E. AGGOLDSTEIN, R.

1986-01-01

The He(2+) and He(+) radial profiles measured by the Giotto mass spectrometer on the inbound trajectory to comet Halley are compared to a simple 1-dimensional charge exchange model. Results indicate that charge exchange alone cannot account for the observed radial profiles of He(2+) and He(+).

Parameters of an indirect exchange in gadolinium and iron compounds

International Nuclear Information System (INIS)

Kupriyanov, A.K.; Nikitin, S.A.

1981-01-01

On the basis of the theory of an indirect exchange and experimental values of hyperfine fields, Curie point and electric resistance, the constants of sd and sf exchange are determined as well as the effective carrier mass for the Gdsub(x)Ysub(1-x)Fesub(3) type compounds. It is shown that the agreement with experiment can be improved on assumption that exchange interactions in the given compounds are realized not only through conductivity electrons but also through collectivized d-type electrons [ru

75 FR 56618 - Self-Regulatory Organizations; BATS Exchange, Inc.; NASDAQ OMX BX, Inc.; Chicago Board Options...

Science.gov (United States)

2010-09-16

... security and its maximum remaining life). \\62\\ See Android Alpha Fund Letter. \\63\\ See Deutsche Bank Letter... SECURITIES AND EXCHANGE COMMISSION [Release No. 34-62884; File Nos. SR-BATS-2010-018; SR-BX-2010... Stock Exchange, Inc.; EDGA Exchange, Inc.; EDGX Exchange, Inc.; International Securities Exchange LLC...

Market Risk in Demutualised Self-Listed Stock Exchanges: An International Analysis of Selected Time-Varying Betas

OpenAIRE

Andrew Worthington; Helen Higgs

2005-01-01

This paper examines market risk in four demutualised and self-listed stock exchanges: the Australian Stock Exchange, the Deutsche Börse, the London Stock Exchange and the Singapore Stock Exchange. Daily company and MSCI index returns provide the respective asset and market portfolio data. A bivariate MA-GARCH model is used to estimate time-varying betas for each exchange from listing until 7 June 2005. While the results indicate significant beta volatility, unit root tests show the betas to b...

Employing Hot Wire Anemometry to Directly Measure the Water Balance of a Proton Exchange Membrane Fuel Cell

DEFF Research Database (Denmark)

Shakhshir, Saher Al; Berning, Torsten

Proton exchange membrane fuel cells (PEMFC’s) are currently being commercialized for various applications ranging from automotive to stationary such as powering telecom back-up units. In PEMFC’s, oxygen from air is internally combined with hydrogen to form water and produce electricity and waste......-hoc and real time electrical signal of the fuel cell water balance by employing hot wire anemometry. The hot wire sensor is placed into a binary mixture of hydrogen and water vapour, and the voltage signal received gives valuable insight into heat and mass transfer phenomena in a PEMFC. A central question...

Theory of oxygen isotope exchange

NARCIS (Netherlands)

den Otter, M.W.; Boukamp, Bernard A.; Bouwmeester, Henricus J.M.

2001-01-01

Transients for oxygen molecular mass numbers 32, 34 and 36 are derived which can be used for the interpretation of oxygen isotope exchange data based on measurement of concentrations of 16O2, 16O18O and 18O2 in the gas phase. Key parameters in the theory are the rate at which oxygen molecules are

Review of Hanford international activities

International Nuclear Information System (INIS)

Panther, D.G.

1993-01-01

Hanford initiated a review of international activities to collect, review, and summarize information on international environmental restoration and waste management initiatives considered for use at Hanford. This effort focused on Hanford activities and accomplishments, especially international technical exchanges and/or the implementation of foreign-developed technologies

The Impact of Foreign Policy on Educational Exchange: The Swedish State Scholarship Programme 1938-1990

Science.gov (United States)

Åkerlund, Andreas

2014-01-01

Programmes of international educational exchange are not only carried out for educational purposes, but form an important part of modern-day public diplomacy. Through exchange programmes education and research are linked with foreign policy interests, which then in turn should affect the international contacts of universities and research…

Global Concept of Financial Institutional Transformation of Stock Exchange

Directory of Open Access Journals (Sweden)

Burmaka Mykola

2017-12-01

Full Text Available The article is about the research of processes of global transformation of stock exchanges through the mechanisms of internationalization, corporate and network consolidation, and technology. Objective processes of internationalization in stock markets affected by financial globalization and arising global information resources create new challenges for stock exchanges that can be overcome by adequate development strategies. The growing competition between stock exchanges and new capital institutes requires stock exchanges to use modern exchange technologies, primarily innovative, in order to maintain liquidity and increase investment attractiveness. Have been analysed the newest tendencies and determinants of modern global financial institutional architecture construction, the leading role in which are starting to play new stock exchanges and stalk exchange platforms, formed in growing financial centres of the world. Have been identified he main components of international stock market restructurization in the process of financial globalization, one of the attributes of which turned out to be a certain fragmentation of markets and their universalization. Through the example of US and EU financial market modernization processes of the last decade have been analysed financial and legal mechanisms of the national and regional levels, which are designed to ensure sustainable development of the global economy at the postcrisis stage. Have been diagnosed international activity of stock exchanges through the quantity indexed of foreign companies in listing, volume of trade with foreign financial instruments, and participation of foreign investors in exchange trade. Have been offered and calculated indices of internationalization of the world’s leading stock market. Have been analysed consolidation processes of the leading stock exchanges and new electronic trading systems at the regional, meso-global and global levels, which resulted in formation of

WMO summit on exchange of weather data may yield to status quo

Science.gov (United States)

Wakefield, Julie

A stalemate may seal the stormy debate over the free exchange of weather data at the upcoming Congress of the World Meteorological Organization (WMO) that begins May 26 in Geneva, U.S. officials say. The central conflict is how to maintain open access for academics while allowing government and industry players to have commercialism.European nations are pushing for a vote on a proposal to develop a two-tiered system for the exchange of international meteorological data. The first-tier data—to include mainly synoptic-scale information—would be freely exchanged internationally; distribution of the second-tier data would be regulated by guidelines established by WMO.

78 FR 23806 - Self-Regulatory Organizations; Miami International Securities Exchange LLC; Notice of Filing and...

Science.gov (United States)

2013-04-22

... participants the ability to utilize an order type that does not route to other exchanges. Specifically, the Do... Exchange is proposing to charge the same rate for transactions in Mini Options, $0.004 per contract, since..., the Exchange feels that it is appropriate to charge the ORF at the same rate as the standard option...

Exchange rate regimes and macroeconomic instabilities in Sub-Saharan Africa

Directory of Open Access Journals (Sweden)

Yaya Camara Seydou

2015-01-01

Full Text Available This article addresses macroeconomic instabilities according to exchange rate regimes in Sub-Saharan Africa (SSA. Based on International Monetary Fund's exchange rate regimes de facto classification, the global sample, SSA, is first divided into two subsamples, which are countries within CFA franc zone (ZCFA and those outside CFA franc zone (HZCFA, and then into four categories, which are the Western Economic and Monetary Union (WAEMU, the Central African Economic and Monetary Community, the countries CFA franc zone with fix exchange rate regimes(HZCFA-FIX, and the countries outside CFA franc zone with flexible exchange rate regimes(HZCFA-FLEX. By applying advanced statistical and econometric methods upon internal and external macroeconomic equilibrium conditions, we show that the inflation, the GDP (or the output and the real exchange rate (RER are very volatile in SSA. However, we found out that they are more volatile in the group HZCFA comparatively to the group ZCFA. We also found out that they are higher in the group HZCFA-FIX than the group HZCFA-FLEX. Moreover, we found out that a high instability of the inflation is combined with those of the output and the RER.

Study of the mass and energy resolution of the E parallel B charge exchange analyzer for TFTR

International Nuclear Information System (INIS)

Kaita, R.; Medley, S.S.

1979-09-01

The charge exchange diagnostic for TFTR requires simultaneous multispecie (H + , D + , γ + ) analysis of particles in the energy range of 0.5 - 150 keV. The analyzer design chosen to provide this capability employs a wide gap semi-circular region of superimposed parallel electric and magnetic fields to accomplish mass and energy resolution, respectively. Combined with a large area, multi-anode microchannel plate detector, this arrangement will enable the energy distributions of protons, deuterions, and tritons to be measured concurrently as a function of time during each discharge. A computer simulation program for calculating ion trajectories through the analyzer was written that includes a realistic model of the magnetic and electrostatic fringe fields. This report presents the results of a study of the proposed E parallel B analyzer, and it reveals that the fringe fields are not detrimental to the performance of the analyzer

Theory and design of heat exchanger : shell and tube condenser and reboiler

International Nuclear Information System (INIS)

Min, Ui Dong

1996-02-01

This book gives descriptions of shell and tube heat exchanger including from, sorts, structure like shell and shell side, channel, and sliding bar, basic design of heat exchanger, flow-induced vibration, shell side condenser, tube side condenser and design of basic structure of condenser by types, selection of reboiler type, kettle type reboiler, internal reboiler, pump through reboiler, design of reboiler like kettle and internal reboiler, and horizontal and vertical thermosyphon reboiler.

SPEEDUPtrademark ion exchange column model

International Nuclear Information System (INIS)

Hang, T.

2000-01-01

A transient model to describe the process of loading a solute onto the granular fixed bed in an ion exchange (IX) column has been developed using the SpeedUptrademark software package. SpeedUp offers the advantage of smooth integration into other existing SpeedUp flowsheet models. The mathematical algorithm of a porous particle diffusion model was adopted to account for convection, axial dispersion, film mass transfer, and pore diffusion. The method of orthogonal collocation on finite elements was employed to solve the governing transport equations. The model allows the use of a non-linear Langmuir isotherm based on an effective binary ionic exchange process. The SpeedUp column model was tested by comparing to the analytical solutions of three transport problems from the ion exchange literature. In addition, a sample calculation of a train of three crystalline silicotitanate (CST) IX columns in series was made using both the SpeedUp model and Purdue University's VERSE-LC code. All test cases showed excellent agreement between the SpeedUp model results and the test data. The model can be readily used for SuperLigtrademark ion exchange resins, once the experimental data are complete

Charge exchange measurements on ISX-A

International Nuclear Information System (INIS)

Neilson, G.H.

1979-04-01

Apparatus and techniques for charge exchange neutral analysis on the ISX-A (Impurity Study Experiment) tokamak are described. A new neutral analyzer incorporating mass-energy resolution was constructed and calibrated for use on ISX. Data interpretation methods which account for profile effects and neutral attenuation have also been developed and were applied to data from the mass-energy analyzer. Examples of data from ISX-A are presented to illustrate both the use of this new instrument and the applicability of the described interpretation techniques

foreign exchange rationing and wheat markets in ethiopia1

African Journals Online (AJOL)

Rahel

markets and the international market are by no means straightforward. ... domestic wheat prices closely tracked import parity prices. Then, from April 2007 to May 2008, good domestic harvests coincided with increase international wheat ... assessing the effects of rationing on real exchange rates and domestic prices of.

How Do Countries Choose their Exchange Rate Regime?

OpenAIRE

Helene Poirson Ward

2001-01-01

This paper investigates the determinants of exchange rate regime choice in 93 countries during 1990-98. Cross-country analysis of variations in international reserves and nominal exchange rates shows that (i) truly fixed pegs and independent floats differ significantly from other regimes and (ii) significant discrepancies exist between de jure and de facto flexibility. Regression results highlight the influence of political factors (political instability and government temptation to inflate),...

Thermo-aerodynamic efficiency of non-circular ducts with vortex enhancement of heat exchange in different types of compact heat exchangers

Science.gov (United States)

Vasilev, V. Ya; Nikiforova, S. A.

2018-03-01

Experimental studies of thermo-aerodynamic characteristics of non-circular ducts with discrete turbulators on walls and interrupted channels have confirmed the rational enhancement of convective heat transfer, in which the growth of heat transfer outstrips or equals the growth of aerodynamic losses. Determining the regularities of rational (energy-saving) enhancement of heat transfer and the proposed method for comparing the characteristics of smooth-channel (without enhancement) heat exchangers with effective analogs provide new results, confirming the high efficiency of vortex enhancement of convective heat transfer in non-circular ducts of plate-finned heat exchange surfaces. This allows creating heat exchangers with much smaller mass and volume for operation in energy-saving modes.

Commodity exchanges - Function and operation

International Nuclear Information System (INIS)

Levin, R.A.

1991-01-01

The author discusses the potential impacts that a futures market may have on the international trade of uranium. The discussion first centers around the New York Mercantile Exchange. The following market aspects are discussed: long-term contracting; spot market; commoditization and pricing; and advantages, disadvantages, risks, and provisions of futures market contracts

Mass and Heat Transfer in Ion-Exchange Membranes Applicable to Solid Polymer Fuel Cells

Energy Technology Data Exchange (ETDEWEB)

Otteroey, M

1996-04-01

In this doctoral thesis, an improved emf method for determination of transference numbers of two counter ions in ion-exchange membranes is presented. Transference numbers were obtained as a continuous function of the composition. The method avoids problems with diffusion by using a stack of membranes. Water transference coefficients in ion-exchange membranes is discussed and reversible and irreversible water transfer is studied by emf methods. Efforts were made to get data relevant to the solid polymer fuel cell. The results support the findings of other researchers that the reversible water transfer is lower than earlier predicted. A chapter on the conductivity of ion-exchange membranes establishes a method to separate the very thin liquid layers surrounding the membranes in a stack. Using the method it was found that the conductivity is obtained with high accuracy and that the liquid layer in a membrane stack can contribute significantly to the total measured resistance. A four point impedance method was tested to measure the conductivity of membranes under fuel cell conditions. Finally, there is a discussion of reversible heat effects and heat transfer in ion-exchange membranes. 155 refs., 45 figs., 13 tabs.

Traveling-wave device with mass flux suppression

Science.gov (United States)

Swift, Gregory W.; Backhaus, Scott N.; Gardner, David L.

2000-01-01

A traveling-wave device is provided with the conventional moving pistons eliminated. Acoustic energy circulates in a direction through a fluid within a torus. A side branch may be connected to the torus for transferring acoustic energy into or out of the torus. A regenerator is located in the torus with a first heat exchanger located on a first side of the regenerator downstream of the regenerator relative to the direction of the circulating acoustic energy; and a second heat exchanger located on an upstream side of the regenerator. The improvement is a mass flux suppressor located in the torus to minimize time-averaged mass flux of the fluid. In one embodiment, the device further includes a thermal buffer column in the torus to thermally isolate the heat exchanger that is at the operating temperature of the device.

Financial Security and Optimal Scale of Foreign Exchange Reserve in China

Directory of Open Access Journals (Sweden)

Guangyou Zhou

2018-05-01

Full Text Available The study of how foreign exchange reserves maintain financial security is of vital significance. This paper provides simulations and estimations of the optimal scale of foreign exchange reserves under the background of possible shocks to China’s economy due to the further opening of China’s financial market and the sudden stop of capital inflows. Focused on the perspective of financial security, this article tentatively constructs an optimal scale analysis framework that is based on a utility maximization of the foreign exchange reserve, and selects relevant data to simulate the optimal scale of China’s foreign exchange reserves. The results show that: (1 the main reason for the fast growth of the Chinese foreign exchange reserve scale is the structural trouble of its double international payment surplus, which creates long-term appreciation expectations for the exchange rate that make it difficult for international capital inflows and excess foreign exchange reserves to enter the real economic growth mechanism under the model of China’s export-driven economy growth; (2 the average optimal scale of the foreign exchange reserve in case of the sudden stop of capital inflows was calculated through parameter estimation and numerical simulation to be 13.53% of China’s gross domestic product (GDP between 1994 and 2017; (3 with the function of the foreign exchange reserves changing from meeting basic transaction demands to meeting financial security demands, the effect of the foreign exchange reserve maintaining the state’s financial security is becoming more and more obvious. Therefore, the structure of foreign exchange reserve assets should be optimized in China, and we will give full play to the special role of foreign exchange reserve in safeguarding a country’s financial security.

Facilitating Cross-Cultural Management Education through Global Faculty Exchanges

Science.gov (United States)

Clinebell, Sharon K.; Kvedaraviciene, Ieva

2013-01-01

According to the AACSB International (Association to Advance Collegiate Schools of Business) (AACSB International, 2011), the next big transformational wave to hit business schools is globalization. Globalizing the faculty is one strategy for enhancing the globalization of business schools and using global faculty exchanges is one method to…

Confirmation of synthetic glucocorticoids with liquid chromatography/mass spectrometry: Organization and results of an international interlaboratory comparison test

NARCIS (Netherlands)

Hauwe, O. van den; Campbell, K.; Crooks, S.R.H.; Schilt, R.; Peteghem, C.H. van

2005-01-01

Within the framework of a European Union (EU) research project entitled "Food Safety Screening: Synthetic Glucocorticoids (QLK1-1999-00122)," an international interlaboratory ring test was organized to compare and evaluate different liquid chromatography/mass spectrometry (LC/MS) confirmatory

78 FR 24273 - Self-Regulatory Organizations; International Securities Exchange, LLC; Order Granting Approval of...

Science.gov (United States)

2013-04-24

... process for exposure is being moved from Supplementary Material .02 to Rule 803 to Supplementary Material... outbound ISO is being routed. The Exchange states that this proposed provision has no impact on customer... cancel orders being routed to another exchange [[Page 24275

Using Monte Carlo Simulation To Improve Cargo Mass Estimates For International Space Station Commercial Resupply Flights

Science.gov (United States)

2016-12-01

The Challenges of ISS Resupply .......................................... 23 F. THE IMPORTANCE OF MASS PROPERTIES IN SPACECRAFT AND MISSION DESIGN...Transportation System TBA trundle bearing assembly VLC verification loads cycle xv EXECUTIVE SUMMARY Resupplying the International Space Station...management priorities. This study addresses those challenges by developing Monte Carlo simulations based on over 13 years of as- flownSS resupply

KRAS G12C Drug Development: Discrimination between Switch II Pocket Configurations Using Hydrogen/Deuterium-Exchange Mass Spectrometry

Energy Technology Data Exchange (ETDEWEB)

Lu, Jia; Harrison, Rane A.; Li, Lianbo; Zeng, Mei; Gondi, Sudershan; Scott, David; Gray, Nathanael S.; Engen, John R.; Westover, Kenneth D. (NEU); (DFCI); (UTSMC); (Harvard-Med)

2017-09-01

KRAS G12C, the most common RAS mutation found in non-small-cell lung cancer, has been the subject of multiple recent covalent small-molecule inhibitor campaigns including efforts directed at the guanine nucleotide pocket and separate work focused on an inducible pocket adjacent to the switch motifs. Multiple conformations of switch II have been observed, suggesting that switch II pocket (SIIP) binders may be capable of engaging a range of KRAS conformations. Here we report the use of hydrogen/deuterium-exchange mass spectrometry (HDX MS) to discriminate between conformations of switch II induced by two chemical classes of SIIP binders. We investigated the structural basis for differences in HDX MS using X-ray crystallography and discovered a new SIIP configuration in response to binding of a quinazoline chemotype. These results have implications for structure-guided drug design targeting the RAS SIIP.

The radioactive inventory of a Berkeley heat exchanger

International Nuclear Information System (INIS)

Hancock, R.

1988-10-01

The Central Electricity Generating Board has announced a date for the final shutdown of the first of the Magnox power stations at Berkeley (March 1989), and is in the process of preparing Pre-Decommissioning Safety Reports (PDSR) for the decommissioning of Berkeley and Bradwell. This report supports these PDSR studies and reports work carried out within the Research Division at Berkeley Nuclear Laboratories on the radioactive inventories of the heat exchangers at Berkeley Power Station. At Berkeley, the heat exchangers will be included in stage two decommissioning to which they will contribute the largest mass of contaminated material. The purpose of this report is to bring together all of the available data on the contamination in the heat exchangers at Berkeley Power Station, and to recommend a database from which the options for disposal of the heat exchangers may be formulated. (author)

Metabolism and gas exchange patterns in Rhodnius prolixus.

Science.gov (United States)

Schilman, Pablo E

Insect's metabolic rate and patterns of gas-exchange varies according to different factors such as: species, activity, mass, and temperature among others. One particular striking pattern of gas-exchange in insects is discontinuous gas-exchange cycles, for which many different hypotheses regarding their evolution have been stated. This article does not pretend to be an extensive review on the subject, rather to focus on the work performed on the haematophagous bug Rhodnius prolixus, a model organism used from the mid XX century until present days, with the great influence of Wigglesworth and his students/collaborator's work. I have no doubt that the renovated field of insect gas-exchange has a bright future and will advance at large gaits thank to the help of this model organism, R. prolixus, whose entire genome has recently being unraveled. Copyright © 2016 Elsevier Ltd. All rights reserved.

Ion exchange currents in vacuum accelerator tubes

International Nuclear Information System (INIS)

Eastham, D.A.; Thorn, R.

1978-01-01

Ion exchange currents (microdischarges) have been observed in short lengths of accelerator tube. The occurrence of these discharges can be related to the trajectories of ions in the tube. High-resolution mass spectra of the negative and positive ion components have been obtained. (author)

Investigating the effect of non-similar fins in thermoeconomic optimization of plate fin heat exchanger

International Nuclear Information System (INIS)

Hajabdollahi, Hassan

2015-01-01

Thermoeconomic optimization of plate fin heat exchanger with similar (SF) and different (DF) or non-similar fin in each side is presented in this work. For this purpose, both heat exchanger effectiveness and total annual cost (TAC) are optimized simultaneously using multi-objective particle swarm optimization algorithm. The above procedure is performed for various mass flow rates in each side. The optimum results reveal that no thermoeconomic improvement is observed in the case of same mass flow rate in each side while both effectiveness and TAC are improved in the case of different mass flow rate. For example, effectiveness and TAC are improved 0.95% and 10.17% respectively, for the DF compared with SF. In fact, the fin configuration should be selected more compact in a side with lower mass flow rate compared with the other side in the thermoeconomic viewpoint. Furthermore, for the thermodynamic optimization viewpoint both SF and DF have the same optimum result while for the economic (or thermoeconomic) optimization viewpoint, the significant decrease in TAC is accessible in the case of DF compared with SF. - Highlights: • Thermoeconomic modeling of compact heat exchanger. • Selection of fin and heat exchanger geometries as nine decision variables. • Applying MOPSO algorithm for multi objective optimization. • Considering the similar and different fin specification in each side. • Investigation of optimum design parameters for various mass flow rates

Endocytic pathway rapidly delivers internalized molecules to lysosomes: an analysis of vesicle trafficking, clustering and mass transfer.

Science.gov (United States)

Pangarkar, Chinmay; Dinh, Anh-Tuan; Mitragotri, Samir

2012-08-20

Lysosomes play a critical role in intracellular drug delivery. For enzyme-based therapies, they represent a potential target site whereas for nucleic acid or many protein drugs, they represent the potential degradation site. Either way, understanding the mechanisms and processes involved in routing of materials to lysosomes after cellular entry is of high interest to the field of drug delivery. Most therapeutic cargoes other than small hydrophobic molecules enter the cells through endocytosis. Endocytosed cargoes are routed to lysosomes via microtubule-based transport and are ultimately shared by various lysosomes via tethering and clustering of endocytic vesicles followed by exchange of their contents. Using a combined experimental and numerical approach, here we studied the rates of mass transfer into and among the endocytic vesicles in a model cell line, 3T3 fibroblasts. In order to understand the relationship of mass transfer with microtubular transport and vesicle clustering, we varied both properties through various pharmacological agents. At the same time, microtubular transport and vesicle clustering were modeled through diffusion-advection equations and the Smoluchowski equations, respectively. Our analysis revealed that the rate of mass transfer is optimally related to microtubular transport and clustering properties of vesicles. Further, the rate of mass transfer is highest in the innate state of the cell. Any perturbation to either microtubular transport or vesicle aggregation led to reduced mass transfer to lysosome. These results suggest that in the absence of an external intervention the endocytic pathway appears to maximize molecular delivery to lysosomes. Strategies are discussed to reduce mass transfer to lysosomes so as to extend the residence time of molecules in endosomes or late endosomes, thus potentially increasing the likelihood of their escape before disposition in the lysosomes. Copyright © 2012 Elsevier B.V. All rights reserved.

78 FR 38424 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2013-06-26

... years, Managed Data Access Distributors have improved the technical delivery and monitoring capabilities... restricting the data flow and monitoring the delivery. The Exchange will maintain contracts with Managed Data... customers. The Exchange has witnessed competitors creating new products and innovative pricing in this space...

Separation of hydrogen isotope by hydrogen-water exchange

International Nuclear Information System (INIS)

Isomura, Shohei; Kaetsu, Hayato; Nakane, Ryohei

1979-01-01

The deuterium exchange reaction between gaseous hydrogen and liquid water is studied by use of three kinds of trickle bed exchange columns packed with hydrophobic catalysts supporting platinum. All columns have the effective lengths of 30 cm. They are 17 mm, 30 mm, and 95 mm in diameters, respectively. The separation experiments are carried out by the once-through methods. The separation efficiencies of the columns are evaluated by the parameters such as the height equivalent to a theoretical plate (H. E. T. P.) and the mass transfer co-efficient. It is found that the operating condition of the exchange column is optimum when the superficial hydrogen flow velocity is 0.3 m/sec. (author)

Preliminary SP-100/Stirling heat exchanger designs

International Nuclear Information System (INIS)

Schmitz, P.; Tower, L.; Blue, B.; Dunn, P.

1994-01-01

Analytic modeling of several heat exchanger concepts to couple the SP-100 nuclear reactor lithium loop and the Space Stirling Power Convertor (SSPC) was performed. Four 25 kWe SSPC's are used to produce the required 100 kW of electrical power. This design work focused on the interface between a single SSPC and the primary lithium loop. Manifolding to separate and collect the four channel flow was not modeled. This work modeled two separate types of heat exchanger interfaces (conductive coupling and radiative coupling) to explore their relative advantages and disadvantages. The minimum mass design of the conductively coupled concepts was 18 kg or 0.73 kg/kWe for a single 25 kWe convertor. The minimum mass radiatively coupled concept was 41 kg or 1.64 kg/kWe. The direct conduction heat exchanger provides a lighter weight system because of its ability to operate the Stirling convertor evaporator at higher heat fluxes than those attainable by the radiatively coupled systems. Additionally the conductively coupled concepts had relatively small volumes and provide potentially simpler assembly. Their disadvantages were the tight tolerances and material joining problems associated with this refractory to superalloy interface. The advantages of the radiatively coupled designs were the minimal material interface problems

Deuterium exchange between hydrogen and water in a trickle bed reactor

International Nuclear Information System (INIS)

Enright, J.T.; Chuang, T.T.

1978-01-01

The catalyzed exchange of deuterium between hydrogen and liquid water has been studied as the basis for a heavy water production process. Platinum catalyst which had been waterproofed with Teflon was tested in a 0.2 m diameter trickle bed reactor at pressures and temperatures up to 6 MPa and 440 K. Extensive experimental data were used to test a model of the system which was developed from fundamental principles. It was found that mass transfer plays a very important role in the overall exchange and the conventional theory of vapour/liquid mass transfer does not adequately describe the absorption process. Modelling of the data has resulted in the postulation of a second method of mass transfer whereby HDO transfers directly from the catalyst to the bulk liquid phase. (author)

Impact of exact exchange in the description of the electronic structure of organic charge-transfer molecular crystals

KAUST Repository

Fonari, Alexandr

2014-10-21

We evaluate the impact that the amount of nonlocal Hartree-Fock (%HF) exchange included in a hybrid density functional has on the microscopic parameters (transfer integrals, band gaps, bandwidths, and effective masses) describing charge transport in high-mobility organic crystals. We consider both crystals based on a single molecule, such as pentacene, and crystals based on mixed-stack charge-transfer systems, such as dibenzo-TTF–TCNQ. In the pentacene crystal, the band gap decreases and the effective masses increase linearly with an increase in the amount of %HF exchange. In contrast, in the charge-transfer crystals, while the band gap increases linearly, the effective masses vary only slightly with an increase in %HF exchange. We show that the superexchange nature of the electronic couplings in charge-transfer systems is responsible for this peculiar evolution of the effective masses. We compare the density functional theory results with results obtained within the G0W0 approximation as a way of benchmarking the optimal amount of %HF exchange needed in a given functional.

Heat exchanger, head and shell acceptance criteria

International Nuclear Information System (INIS)

Lam, P.S.; Sindelar, R.L.

1992-09-01

Instability of postulated flaws in the head component of the heat exchanger could not produce a large break, equivalent to a DEGB in the PWS piping, due to the configuration of the head and restraint provided by the staybolts. Rather, leakage from throughwall flaws in the head would increase with flaw length with finite leakage areas that are bounded by a post-instability flaw configuration. Postulated flaws at instability in the shell of the heat exchanger or in the cooling water nozzles could produce a large break in the Cooling Water System (CWS) pressure boundary. An initial analysis of flaw stability for postulated flaws in the heat exchanger head was performed in January 1992. This present report updates that analysis and, additionally, provides acceptable flaw configurations to maintain defined structural or safety margins against flaw instability of the external pressure boundary components of the heat exchanger, namely the head, shell, and cooling water nozzles. Structural and flaw stability analyses of the heat exchanger tubes, the internal pressure boundary of the heat exchangers or interface boundary between the PWS and CWS, were previously completed in February 1992 as part of the heat exchanger restart evaluation and are not covered in this report

Enhancement of combined heat and mass transfer in a vertical-tube heat and mass exchanger

International Nuclear Information System (INIS)

Webb, R.L.; Perez-Blanco, H.

1986-01-01

This paper studies enhancement of heat and mass transfer between a countercurrent, gravity-drained water film and air flowing in a vertical tube. The enhancement technique employed is spaced, transverse wires placed in the air boundary layer, near the air--water interface. Heat transfer correlations for turbulent, single-phase heat transfer in pipes having wall-attached spaced ribs are used to select the preferred wire diameter, and to predict the gas phase heat and mass transfer coefficients. Tests were run with two different radial placements of the rib roughness: (1) at the free surface of the liquid film, and (2) the base of the roughness displaced 0.51 mm into the air flow. The authors hypothesize that the best heat/mass transfer and friction performance will be obtained with the roughness at the surface of the water film. Experiments conducted with both roughness placements show that the authors' hypothesis is correct. The measured heat/mass transfer enhancement agreed very closely with the predicted values. A unique feature of the enhancement concept is that it does not require surface wetting of the enhancement device to provide enhancement

Selection of greenery plants' group tolerant to mineralized human wastes for their inclusion into intrasystem mass exchange of BTLSS

Science.gov (United States)

Tikhomirova, Natalia; Tikhomirov, Alexander A.; Kalacheva, Galina; Ushakova, Sofya; Trifonov, Sergey V.; Pavlova, Anastasiya

2016-07-01

A possible way solving the inclusion problem of the human liquid wastes containing sodium chloride into intrasystem mass exchange of bio-technical life support system (BTLSS) is selection of such species of greenery plants that can utilize sodium chloride, be edible for a human and have rather a high productivity. Our previous works showed that salt-accumulating halophyte Salicornia europaea L. was a promising candidate for sodium chloride inclusion into BTLSS mass exchange. However, with the aim of creation of more various human diet possibilities a set of greenery plants cultivated by the water culture method was estimated. Based on preliminary experiments the plants Brassica juncea L., Nasturtium officinale R. Br., Lepidium sativum angustifolia L. and Salicornia europaea L. were chosen as the investigation objects. The nutrient solution for greenery plant's cultivation was obtained after harvesting the wheat plants grown on the solution with mineralized human wastes' addition. The results of the first stage of the investigations carried out showed that plants of Brassica juncea and Lepidium sativum angustifolia are unpromising for their inclusion into BTLSS because of a set of physiological characteristics. On the next stage of investigations, an experimental model of closed ecosystem was created. For that purpose the plants of Salicornia europaea and Nasturtium officinale were introduced in the phototroph unit structure. It was determined that there was deficiency of main macronutrients for Salicornia europaea and Nasturtium officinale including sodium for Salicornia europaea. The deficiency had an effect on plants productivity and on carry-over of sodium from solution by Salicornia europaea. Thus in the future experiment it is necessary to carry out desalinization of solution by Salicornia europaea plants. Nasturtium officinale, that is rich in essential fatty acids and contributes into variety of human vegetable diet is planned to be cultivated by the

77 FR 16883 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Science.gov (United States)

2012-03-22

...) (noting that the Chicago Mercantile Exchange moved the S&P 500[supreg] futures contract's settlement value... related market disruptions during that period in connection with the dual a.m./p.m.-settlement.\\18..., routine oversight inspections of the Exchange's regulatory programs by the Commission have not uncovered...

Fostering internationalization: an American-Danish semester-long undergraduate nursing student exchange program.

Science.gov (United States)

Baernholdt, M; Drake, E; Maron, F; Neymark, K

2013-06-01

This paper describes the development, implementation and evaluation of a semester-long exchange program between two Bachelor of Science in Nursing programs in the USA and Denmark. Nurses globally need to provide culturally sensitive care for an ethnically diverse population. Competencies on how to do so should start in basic nursing programs. A useful strategy is through immersion into another culture through an exchange program. Little is known about successful strategies for two-way or 360° exchange programs between schools from different countries. Guided by experiential learning theory, we developed an exchange program with the objective of enhancing nursing students' cultural competence through knowledge building, attitudes and behaviour development. Lessons learned and implications for educational institutions and policy are discussed. In internationalization of nursing education, an awareness of underlying cultural values regarding nursing competence and taking appropriate action are important for success. Other areas for a successful exchange program include matching of courses or content across schools, clear objectives and evaluation plans. Finally, flexibility and open communication are key components when setting up a 360° exchange program. © 2013 The Authors. International Nursing Review © 2013 International Council of Nurses.

The Inflaton and its Mass

OpenAIRE

Brout, Robert

2002-01-01

In the context of the two fluid model of space-time fluctuations proposed to tame the transplanckian problem encountered in black hole physics, it is postulated that the inflaton is the fluctuation of mode density, ``the vapor component'' of the model. The mass of the inflaton is occasioned by the exchange of degrees of freedom between the ``vapor'' and the ``liquid'', the planckian ``soup'' in which usual ``cisplanckian'' fields propagate. This exchange between vacuum fluctuations is modeled...

Modeling and optimization of a shell and louvered fin mini-tubes heat exchanger in an ORC powered by an internal combustion engine

International Nuclear Information System (INIS)

Mastrullo, Rita; Mauro, Alfonso William; Revellin, Rémi; Viscito, Luca

2015-01-01

Highlights: • New ORC HEX design. • Dedicated model. • On-road uses. • Simulations for real ICEs’ conditions. - Abstract: Waste heat recovery from exhaust gases of internal combustion engines (ICEs) is an interesting option to increase energy conversion efficiency, especially on on-road applications. Organic Rankine cycles (ORCs) fit well the temperature levels available. Current research interests are devoted to the definition of new design solutions to improve each part of the energy conversion process. Concerning the heat recovery, new concepts for heat exchangers are required to reduce their weight, the refrigerant charge and the related environmental concerns. At the same time, a high performance of the whole system must be kept. In this paper, a new design is introduced related to a shell and louvered fin mini-tubes heat exchanger. Modeling and simulation results are presented to define an optimal design in the whole map of working conditions for a heavy duty diesel engine and a light duty gasoline engine, in order to maximize the overall system efficiency (ORC+ICE). The length and weight of the heat exchanger are consistent with the use in automotive and truck applications, while an increase of the overall system efficiency up to 9% can be achieved

Some Tests of Random Walk Hypothesis for Bulgarian Foreign Exchange Rates

OpenAIRE

Nikolai Gueorguiev

1993-01-01

The objective of this paper is to check if the exchange rate in newly emerged, relatively thin foreign exchange markets, follows a random walk pattern. The findings of the current study cast doubts on random walk presence in Bulgarian exchange rates against major international currencies. It turns out that the series of daily returns are stationary but correlated and therefore can be modelled better by higher-order ARIMA processes than by random walk.

77 FR 10016 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2012-02-21

... for complex orders in two of the most actively-traded index option products, the NASDAQ 100 Index... makers to enter quotations for complex order strategies in the Complex Order Book,\\8\\ the Exchange... because they are consistent with price differentiation that exists today at other option exchanges. The...

75 FR 29381 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...

Science.gov (United States)

2010-05-25

... compelling need to attract order flow, imposed significant competitive pressure on that exchange's need to... competitive pressures on the ISE Order Feed and ISE's compelling need to attract order flow impose significant competitive pressure on the Exchange to act equitably, fairly, and reasonably in setting its fees. B. Self...

77 FR 3295 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing and...

Science.gov (United States)

2012-01-23

... PHLX, Inc. (``PHLX'') and Nasdaq Options Market (``NOM'') Update Pricing Effective January 3, 2012... pricing that reduces rates for market makers based on the level of business they bring to the Exchange.\\11\\ This proposed rule change targets a particular segment in which the Exchange seeks to garnish greater...

Effects of exchange rate volatility on export volume and prices of forest products

Science.gov (United States)

Sijia Zhang; Joseph Buongiorno

2010-01-01

The relative value of currencies varies considerably over time. These fluctuations bring uncertainty to international traders. As a result, the volatility in exchange rate movements may influence the volume and the price of traded commodities. The volatility of exchange rates was measured by the variance of residuals in a GARCH(1,1) model of the exchange rate. We...

Optimizing Higgs factories by modifying the recoil mass

Science.gov (United States)

Gu, Jiayin; Li, Ying-Ying

2018-02-01

It is difficult to measure the WW-fusion Higgs production process ({{{e}}}+{{{e}}}-\\to {{ν }}\\bar{{{ν }}}{{h}}) at a lepton collider with a center of mass energy of 240-250 GeV due to its small rate and the large background from the Higgsstrahlung process with an invisible Z ({{{e}}}+{{{e}}}-\\to {{hZ}},{{Z}}\\to {{ν }}\\bar{{{ν }}}). We construct a modified recoil mass variable, {m}{{recoil}}p, defined using only the 3-momentum of the reconstructed Higgs particle, and show that it can separate the WW-fusion and Higgsstrahlung events better than the original recoil mass variable m recoil. Consequently, the {m}{{recoil}}p variable can be used to improve the overall precisions of the extracted Higgs couplings, in both the conventional framework and the effective-field-theory framework. We also explore the application of the {m}{{recoil}}p variable in the inclusive cross section measurements of the Higgsstrahlung process, while a quantitive analysis is left for future studies. JG is Supported by an International Postdoctoral Exchange Fellowship Program between the Office of the National Administrative Committee of Postdoctoral Researchers of China (ONACPR) and DESY. YYL is Supported by Hong Kong PhD Fellowship (HKPFS) and the Collaborative Research Fund (CRF) (HUKST4/CRF/13G)

Does exchange of information between tax authorities influence multinationals' use of tax havens?

OpenAIRE

Braun, Julia; Weichenrieder, Alfons

2015-01-01

Since the mid-1990s, countries offering tax systems that facilitate international tax avoidance and evasion have been facing growing political pressure to comply with the internationally agreed standards of exchange of tax information. Using data of German investments in tax havens, we find evidence that the conclusion of a bilateral tax information exchange agreement (TIEA) is associated with fewer operations in tax havens and the number of German affiliates has on average ...

Nucleon-delta mass difference in the chiral bag plus skyrmion hybrid model

International Nuclear Information System (INIS)

Kusaka, K.; Toki, H.

1988-01-01

We study the nucleon-delta isobar mass difference in the chiral bag plus skyrmion hybrid model (CSH). While in the Skyrme model the collective rotation solely provides the mass difference, in the CSH model the one-gluon exchange process also contributes in addition to the collective rotation due to the broken symmetry restoration. We study the one-gluon exchange contribution using the collective coordinate projection method. We find that the one-gluon exchange energy tends to compensate for the decreasing tendency of the rotational energy in the large bag region. (orig.)

A Liquid-Liquid Thermoelectric Heat Exchanger as a Heat Pump for Testing Phase Change Material Heat Exchangers

Science.gov (United States)

Sheth, Rubik B.; Makinen, Janice; Le, Hung V.

2016-01-01

The primary objective of the Phase Change HX payload on the International Space Station (ISS) is to test and demonstrate the viability and performance of Phase Change Material Heat Exchangers (PCM HX). The system was required to pump a working fluid through a PCM HX to promote the phase change material to freeze and thaw as expected on Orion's Multipurpose Crew Vehicle. Due to limitations on ISS's Internal Thermal Control System, a heat pump was needed on the Phase Change HX payload to help with reducing the working fluid's temperature to below 0degC (32degF). This paper will review the design and development of a TEC based liquid-liquid heat exchanger as a way to vary to fluid temperature for the freeze and thaw phase of the PCM HX. Specifically, the paper will review the design of custom coldplates and sizing for the required heat removal of the HX.

Kinetics of the high temperature oxygen exchange reaction on {sup 238}PuO{sub 2} powder

Energy Technology Data Exchange (ETDEWEB)

Whiting, Christofer E., E-mail: chris.whiting@udri.udayton.edu [University of Dayton – Research Institute, 300 College Park, Dayton, OH 45469-0172 (United States); Du, Miting; Felker, L. Kevin; Wham, Robert M. [Oak Ridge National Laboratory, P.O. Box 2008, Oak Ridge, TN 37831 (United States); Barklay, Chadwick D.; Kramer, Daniel P. [University of Dayton – Research Institute, 300 College Park, Dayton, OH 45469-0172 (United States)

2015-12-15

Oxygen exchange reactions performed on PuO{sub 2} suggest the reaction is influenced by at least three mechanisms: an internal chemical reaction, surface mobility of active species/defects, and surface exchange of gaseous oxygen with lattice oxygen. Activation energies for the surface mobility and internal chemical reaction are presented. Determining which mechanism is dominant appears to be a complex function including at least specific surface area and temperature. Thermal exposure may also impact the oxygen exchange reaction by causing reductions in the specific surface area of PuO{sub 2}. Previous CeO{sub 2} surrogate studies exhibit similar behavior, confirming that CeO{sub 2} is a good qualitative surrogate for PuO{sub 2}, in regards to the oxygen exchange reaction. Comparison of results presented here with previous work on the PuO{sub 2} oxygen exchange reaction allows complexities in the previous work to be explained. These explanations allowed new conclusions to be drawn, many of which confirm the conclusions presented here. - Highlights: • PuO{sub 2} Oxygen exchange kinetics can be influenced by at least 3 different mechanisms. • An internal chemical reaction controls the rate at high temperature and large SSA. • Surface mobility and surface exchange influence rate at lower temperatures and SSA. • Exchange temperatures may alter SSA and make data difficult to interpret.

78 FR 13717 - Self-Regulatory Organizations; International Securities Exchange, LLC; Notice of Filing of...