WorldWideScience

Sample records for interaction region encounter

  1. The solar wind interaction with comets: A post encounter view

    Science.gov (United States)

    Mendis, D. A.

    1987-01-01

    The recent spacecraft encounters with comets Giacobini-Zinner and Halley have led to an enormous increase in our knowledge of comets, including their dust, neutral gas, plasma, and magnetic field environments. The latter has in turn led to better understanding of the nature of the solar wind interaction with the well developed atmosphere of a comet. The post-encounter understanding of this interaction is reviewed, underscoring the differences with pre-encounter reasoning. The problems outstanding in this area are emphasized.

  2. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  3. Encountering Nanotechnology in an Interactive Exhibition

    Science.gov (United States)

    Murriello, Sandra E.; Knobel, Marcelo

    2008-01-01

    This article offers findings from a learning sciences-informed evaluation of a nanoscience and nanotechnology exhibition called Nano-Aventura (NanoAdventure), based on four interactive-collaborative games and two narrated videos. This traveling exhibition was developed in Brazil by the Museu Exploratorio de Ciencias for children and teenagers…

  4. Sensory information and encounter rates of interacting species.

    Directory of Open Access Journals (Sweden)

    Andrew M Hein

    Full Text Available Most motile organisms use sensory cues when searching for resources, mates, or prey. The searcher measures sensory data and adjusts its search behavior based on those data. Yet, classical models of species encounter rates assume that searchers move independently of their targets. This assumption leads to the familiar mass action-like encounter rate kinetics typically used in modeling species interactions. Here we show that this common approach can mischaracterize encounter rate kinetics if searchers use sensory information to search actively for targets. We use the example of predator-prey interactions to illustrate that predators capable of long-distance directional sensing can encounter prey at a rate proportional to prey density to the [Formula: see text] power (where [Formula: see text] is the dimension of the environment when prey density is low. Similar anomalous encounter rate functions emerge even when predators pursue prey using only noisy, directionless signals. Thus, in both the high-information extreme of long-distance directional sensing, and the low-information extreme of noisy non-directional sensing, encounter rate kinetics differ qualitatively from those derived by classic theory of species interactions. Using a standard model of predator-prey population dynamics, we show that the new encounter rate kinetics derived here can change the outcome of species interactions. Our results demonstrate how the use of sensory information can alter the rates and outcomes of physical interactions in biological systems.

  5. Sensory information and encounter rates of interacting species.

    Science.gov (United States)

    Hein, Andrew M; McKinley, Scott A

    2013-01-01

    Most motile organisms use sensory cues when searching for resources, mates, or prey. The searcher measures sensory data and adjusts its search behavior based on those data. Yet, classical models of species encounter rates assume that searchers move independently of their targets. This assumption leads to the familiar mass action-like encounter rate kinetics typically used in modeling species interactions. Here we show that this common approach can mischaracterize encounter rate kinetics if searchers use sensory information to search actively for targets. We use the example of predator-prey interactions to illustrate that predators capable of long-distance directional sensing can encounter prey at a rate proportional to prey density to the [Formula: see text] power (where [Formula: see text] is the dimension of the environment) when prey density is low. Similar anomalous encounter rate functions emerge even when predators pursue prey using only noisy, directionless signals. Thus, in both the high-information extreme of long-distance directional sensing, and the low-information extreme of noisy non-directional sensing, encounter rate kinetics differ qualitatively from those derived by classic theory of species interactions. Using a standard model of predator-prey population dynamics, we show that the new encounter rate kinetics derived here can change the outcome of species interactions. Our results demonstrate how the use of sensory information can alter the rates and outcomes of physical interactions in biological systems.

  6. Early interactions during the encounter of plants, aphids and arboviruses.

    Science.gov (United States)

    Bak, Aurélie; Martinière, Alexandre; Blanc, Stéphane; Drucker, Martin

    2013-06-01

    Aphids infest many plants and cause damage by depriving them of nutrients and by transmitting many viral diseases. Aphid infestation and arbovirus transmission are controlled by establishment (or not) of a compatible reaction between the insects and the plants. This reaction is the result of defense reactions of the plant and counter-defense reactions of the parasite. Contrarily to plant-bacteria, plant-fungi and plant-herbivorous insects pathosystems, the plant-aphid pathosystem is understudied, although recent advances have begun to uncover some of its details. Especially the very early steps in plant-aphid interactions are hardly known. We here resume the present knowledge of these interactions. We discuss further how an aphid-transmitted plant virus that is transmitted during the first moments of the plant-aphid encounter, might help to study the very early plant aphid interactions.

  7. A Close Encounter with a Saturn Kilometric Radiation Source Region

    Science.gov (United States)

    Kurth, W. S.; Gurnett, D. A.; Menietti, J. D.; Mutel, R. L.; Kivelson, M. G.; Bunce, E. J.; Cowley, S. W. H.; Talboys, D. L.; Dougherty, M. K.; Arridge, C.; Coates, A.; Grimald, S.; Lamy, L.; Zarka, P.; Cecconi, B.; Schippers, P.; André, N.; Louarn, P.; Mitchell, D.; Leisner, J.; Morooka, M.

    Earth-orbiting satellites have routinely traversed the source regions of auroral kilometric radiation. This radio emission is generated via the cyclotron maser instability very close to the electron cyclotron frequency. While Cassini's orbit has crossed auroral field lines, the radial distance at auroral latitudes is typically too high for the analogous Saturn kilometric radiation source. However, on Oct. 17, 2008, the Radio and Plasma Wave Science instrument detected the kilometric radiation at and just below the electron cyclotron frequency. At this time the spacecraft was at a distance of 5 Saturn radii, at 0.9 hours local time, and on L-shells in the range of 25 to above 30. Here the magnetic field suggests the corresponding current was directed upward, away from the planet. Low energy electron observations by the Cassini Plasma Spectrometer instrument suggest that growth of the SKR is likely due to an unstable shell-like distribution.

  8. Estimates of Terms in Ohm's Law During an Encounter with an Electron Diffusion Region

    Science.gov (United States)

    Torbert, R. B.; Burch, J. L.; Giles, B. L.; Gershman, D.; Pollock, C. J.; Dorelli, J.; Avanov, L. A.; Argall, M.; Shuster, J.; Strangeway, R.; hide

    2016-01-01

    We present measurements from the Magnetospheric Multiscale (MMS) mission taken during a reconnection event on the dayside magnetopause which includes a passage through an electron diffusion region (EDR). The four MMS satellites were separated by about 10 km such that estimates of gradients and divergences allow a reasonable estimate of terms in the generalized Ohm's law, which is key to investigating the energy dissipation during reconnection. The strength and character of dissipation mechanisms determines how magnetic energy is released. We show that both electron pressure gradients and electron inertial effects are important, but not the only participants in reconnection near EDRs, since there are residuals of a few mVm (approximately 30-50%) of E+ U(sub e) x B (from the sum of these two terms) during the encounters. These results are compared to a simulation, which exhibits many of the observed features, but where relatively little residual is present.

  9. Classroom Interactions as Cross-Cultural Encounters: Native Speakers in EFL Lessons

    Science.gov (United States)

    Luk, Jasmine C. M.; Lin, Angel M. Y.

    2006-01-01

    This book is about native English speakers teaching English as a global language in non-English speaking countries. Through analysis of naturally occurring dialogic encounters, the authors examine the multifaceted ways in which teachers and students utilize diverse communicative resources to construct, display, and negotiate their identities as…

  10. Self-construal, affective valence of the encounter, and quality of social interactions: Within and cross-culture examination.

    Science.gov (United States)

    Kafetsios, Konstantinos; Hess, Ursula; Nezlek, John B

    2017-03-15

    In two samples, one from Greece and another from Germany, we examined relationships between self-construal, emotional experience, and the quality of social interactions. In Greece, a more collectivistic culture, the negative affect people experienced in social interactions was more weakly related to the quality of social interactions for those higher in interdependent self-construal than it was for those lower in interdependent self-construal. In Germany, a more independent culture, a contrasting pattern was observed such that the positive affect people experienced in social interaction was more strongly related to the quality of social interactions for those higher in independent self-construal than it was for those lower in independent self-construal. These findings suggest that positive and negative affect in social encounters can have different effects for persons with independent and interdependent cultural orientations within different cultural settings.

  11. Electromagnetic Wave-filled Cavities Observed by the GEODESIC Sounding Rocket: A Direct Encounter with VLF Saucer Source Regions

    Science.gov (United States)

    Kabirzadeh, Rasoul

    The GEODESIC sounding rocket encountered hundreds of localized, VLF-wave-filled density depletions in an auroral return current region at altitudes between 900--1000 km. While these are similar to well-studied lower-hybrid "spikelets", which are electrostatic, many of the GEODESIC events exhibited strong VLF magnetic field enhancements as well. In the present study we show that these magnetic field fluctuations can be interpreted as the result of geomagnetic field-aligned electron currents driven by fluctuating electric fields parallel to the geomagnetic field lines. This observation suggests that the electromagnetic wave-filled cavities are signatures of unstable filaments of return current fluctuating at VLF frequencies. We argue that the cavities' spatial dimensions, their location inside the return current region and their total radiated power are consistent with the properties of VLF saucer source regions inferred from earlier satellite observations taken at higher altitudes.

  12. Problems encountered by teenage mothers in the Southern Hho-Hho region of Swaziland

    Directory of Open Access Journals (Sweden)

    Valerie J Ehlers

    2003-03-01

    Full Text Available A qualitative, explorative, descriptive and contextual research approach was followed to study the problems experiencedby teenage mothers in the southern Hho-Hho region of Swaziland. Opsomming ’n Kwalitatiewe, eksploratiewe, beskrywende en kontekstuele navorsingsbenadering is gevolg tydens die studie van probleme wat deur tienermoeders in die suidelike Hho-Hho gebied van Swaziland ondervind is. *Please note: This is a reduced version of the abstract. Please refer to PDF for full text.

  13. Constraints Encountered by the Beneficiaries of Krishi Vigyan Kendra in North Eastern Region of India

    Directory of Open Access Journals (Sweden)

    Dipak Nath

    2017-04-01

    Full Text Available The study was conducted among 200 farmers of ten purposively selected Krishi Vigyan Kendras (KVKs in North Eastern region of India. The respondents were interviewed using a questionnaire for identifying the constraints and their suggestions for future improvement of KVK activities. The study revealed that unavailability of labour, unavailability of good quality seed and other inputs, unavailability of information about pest and disease management at right time,(inability to purchase modern agricultural implements and lack of capital were the major constraints. The respondents suggested that timely availability of seed and other inputs, regular and continuous monitoring, linking farmers to financial institutuions for financial support, and more long term practical oriented training programme are important for strengthening KVK activities.

  14. Language Learner/Native Speaker Interactions: Exploring Adaptability in Intercultural Encounters

    Science.gov (United States)

    Chamberlin-Quinlisk, Carla

    2010-01-01

    Diversity and intercultural awareness initiatives are increasingly common at institutions of higher education in the USA. Although students recognize and appreciate the diversity of their surroundings, studies show that intercultural interactions at the social level are lacking. This study focuses on how English language learners, multilingual…

  15. Language Learner/Native Speaker Interactions: Exploring Adaptability in Intercultural Encounters

    Science.gov (United States)

    Chamberlin-Quinlisk, Carla

    2010-01-01

    Diversity and intercultural awareness initiatives are increasingly common at institutions of higher education in the USA. Although students recognize and appreciate the diversity of their surroundings, studies show that intercultural interactions at the social level are lacking. This study focuses on how English language learners, multilingual…

  16. Ocean acidification and host-pathogen interactions: blue mussels, Mytilus edulis, encountering Vibrio tubiashii.

    Science.gov (United States)

    Asplund, Maria E; Baden, Susanne P; Russ, Sarah; Ellis, Robert P; Gong, Ningping; Hernroth, Bodil E

    2014-04-01

    Ocean acidification (OA) can shift the ecological balance between interacting organisms. In this study, we have used a model system to illustrate the interaction between a calcifying host organism, the blue mussel Mytilus edulis and a common bivalve bacterial pathogen, Vibrio tubiashii, with organisms being exposed to a level of acidification projected to occur by the end of the 21st century. OA exposures of the mussels were carried out in relative long-term (4 months) and short-term (4 days) experiments. We found no effect of OA on the culturability of V. tubiashii, in broth or in seawater. OA inhibited mussel shell growth and impaired crystalline shell structures but did not appear to affect mussel immune parameters (i.e haemocyte counts and phagocytotic capacity). Despite no evident impact on host immunity or growth and virulence of the pathogen, V. tubiashii was clearly more successful in infecting mussels exposed to long-term OA compared to those maintained under ambient conditions. Moreover, OA exposed V. tubiashii increased their viability when exposed to haemocytes of OA-treated mussel. Our findings suggest that even though host organisms may have the capacity to cope with periods of OA, these conditions may alter the outcome of host-pathogen interactions, favouring the success of the latter.

  17. The interactional establishment of the membership category ‘nonnative speaker’ in gatekeeping encounters

    DEFF Research Database (Denmark)

    Tranekjær, Louise; Kappa, Katherine

    2016-01-01

    This paper examines how the membership category ‘nonnative speaker’ is interactionally established and initiated by the ‘native speaker’ interviewers during internship interviews between Danish employers and born abroad1 candidates. The analysis is based on 16 recorded internship interviews...... different ways in which the interviewers orient to and establish the candidate as a member of the category ‘nonnative speaker’ without performing other-repair. Thus, the paper focuses on orientations to proficiency that are not related to linguistic errors or repair-sequences. The direct address...... of the interviewers’ orientations to the candidates’ proficiency in our data is noteworthy as it is in stark contrast to previous research which show that other-repair is rarely initiated by native speakers in native/nonnative speaker settings. We argue that language-related membership categorization processes...

  18. Using video-based observation research methods in primary care health encounters to evaluate complex interactions.

    Science.gov (United States)

    Asan, Onur; Montague, Enid

    2014-01-01

    The purpose of this paper is to describe the use of video-based observation research methods in primary care environment and highlight important methodological considerations and provide practical guidance for primary care and human factors researchers conducting video studies to understand patient-clinician interaction in primary care settings. We reviewed studies in the literature which used video methods in health care research, and we also used our own experience based on the video studies we conducted in primary care settings. This paper highlighted the benefits of using video techniques, such as multi-channel recording and video coding, and compared "unmanned" video recording with the traditional observation method in primary care research. We proposed a list that can be followed step by step to conduct an effective video study in a primary care setting for a given problem. This paper also described obstacles, researchers should anticipate when using video recording methods in future studies. With the new technological improvements, video-based observation research is becoming a promising method in primary care and HFE research. Video recording has been under-utilised as a data collection tool because of confidentiality and privacy issues. However, it has many benefits as opposed to traditional observations, and recent studies using video recording methods have introduced new research areas and approaches.

  19. Encountering Materiality

    DEFF Research Database (Denmark)

    Svabo, Connie

    2016-01-01

    DHT researcher Connie Svabo and artist Charlotte Grum did a joint performance presentation titled Becoming Sheep, Becoming Animal at the international conference Encountering Materiality – Transdisciplinary Conversations, held in Geneve, Schwitzerland, June 23-25 2016.......DHT researcher Connie Svabo and artist Charlotte Grum did a joint performance presentation titled Becoming Sheep, Becoming Animal at the international conference Encountering Materiality – Transdisciplinary Conversations, held in Geneve, Schwitzerland, June 23-25 2016....

  20. Encountering Materiality

    DEFF Research Database (Denmark)

    Svabo, Connie

    2016-01-01

    DHT researcher Connie Svabo and artist Charlotte Grum did a joint performance presentation titled Becoming Sheep, Becoming Animal at the international conference Encountering Materiality – Transdisciplinary Conversations, held in Geneve, Schwitzerland, June 23-25 2016.......DHT researcher Connie Svabo and artist Charlotte Grum did a joint performance presentation titled Becoming Sheep, Becoming Animal at the international conference Encountering Materiality – Transdisciplinary Conversations, held in Geneve, Schwitzerland, June 23-25 2016....

  1. Migrant encounters in the clinic: Bureaucratic, biomedical, and community influences on patient interactions with front-line workers.

    Science.gov (United States)

    Smith, Sarah A

    2016-02-01

    Ethnographic research on the clinical encounter has focused almost exclusively on what happens in exam rooms-particularly patient-provider interactions-leaving much to be understood about other actors within the clinic. As part of a larger ethnographic study examining the impact of colonialism, transnational migration, discrimination, and gender relations on Chuukese migrant women's reproductive and sexual health outcomes in Guam, I conducted eight months of participant observation in three publicly funded health clinics, 24 interviews with health care workers, and 15 life-history interviews with Chuukese women between September 2012 and February 2014. Findings demonstrated differential treatment of Chuukese patients by front-line workers (FLWs), who engaged in "boundary work" with these patients. Further, care varied by clinic space and the actors in that space. This differential treatment and variation in care impacted Chuukese women's access to and experiences with health care in Guam. Utilizing the concept of "deservingness," this analysis unpacks how FLWs, like Lipsky's "street-level bureaucrats," are influenced by bureaucratic, biomedical, and community hierarchies, all contributing to differential patient treatment. This study concludes by calling for more integrated analyses of clinical environments which utilize Lipsky's concept to include community narratives of "deservingness" and incorporate the influence of clinic and community stratification.

  2. Cosmopolitan encounters

    DEFF Research Database (Denmark)

    Plage, Stefanie; Willing, Indigo; Woodward, Ian

    2017-01-01

    This study contributes to the growing research on everyday cosmopolitanism in diverse societies. We employ a cosmopolitan encounters framework to explore the reflexive openness people perform and the ethical reasoning they draw on to get along with each other. In particular, we look beyond pleasu...

  3. Interaction Region Issues at the NLC

    Energy Technology Data Exchange (ETDEWEB)

    Markiewicz, Thomas W.; Maruyama, T.; /SLAC

    2007-09-26

    Two detector concepts are being investigated for the Next Linear Collider. This paper discusses the current design of the interaction region for one of them, based on a 6 Tesla solenoid and silicon based tracking. Topics include masking layout, backgrounds and the suppression of final quadrupole jitter. All calculations are based on the 1 TeV design parameters.

  4. An Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters

    NARCIS (Netherlands)

    Delcourt, C.C.; Gremler, D; Zanet, F. de; Riel, A.C.R. van

    2017-01-01

    PURPOSE - Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the criticali

  5. An Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters

    NARCIS (Netherlands)

    Delcourt, C.C.; Gremler, D; Zanet, F. de; Riel, A.C.R. van

    2017-01-01

    PURPOSE - Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the

  6. An Analysis of the Interaction Effect between Employee Technical and Emotional Competencies in Emotionally Charged Service Encounters

    OpenAIRE

    Delcourt, Cécile; Gremler, Dwayne; De Zanet, Fabrice; Riel van, Allard

    2017-01-01

    Purpose—Customers often experience negative emotions during service experiences. The ways that employees manage customers’ emotions and impressions about whether the service provider is concerned for them in such emotionally charged service encounters (ECSEs) is crucial, considering the criticality of the encounter. Drawing on cognitive appraisal theory, this study proposes that two key competencies—employee emotional competence (EEC) and employee technical competence (ETC)—affect negative cu...

  7. Moving Encounters

    Directory of Open Access Journals (Sweden)

    Ann Deslandes

    2011-04-01

    Full Text Available This essay explores my experience of losing an authoritative speaking position – that is, ‘falling on my face’ in a research encounter with the Brazilian Landless Worker’s Movement (O Movimento dos Trabalhadores Rurais sem Terra, or MST.  My specific movements through this locale invoke Gayatri Chakravorty Spivak’s concept of ‘unlearning one’s privilege as a loss’; and Sara Ahmed’s theory of ‘stranger fetishism’.  In writing my brief loss, I also; of course, recover my speaking position, meaning that I can always efface the loss by re-writing it as a source of ethnographic authority.  This essay is written in two voices in order to reflect this paradox: one which describes the encounter, and one that critically ruminates upon it.  I note, for example, that the MST as a variegated conglomerate of people takes the form of particular ‘Others’ when they are represented in the scholarship and polemic of ‘first world’ activists in the so called ‘global justice movement’.  ‘Falling on my face in the street’ of these Others locates particular processes of fetishization within the global justice movement and the relationships across power and difference that are contained herein; processes that impact on the idea of a ‘global’ solidarity against systemic ‘global’ oppressions.

  8. MEIC Detector and Interaction Region at JLab

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, Zhiwen [Duke University, Durham, NC

    2015-09-01

    The Electron-Ion Collider (EIC) is envisioned as the next-generation US facility for exploring the strong interaction. The Medium-energy EIC (MEIC) is the first stage of the EIC at Jefferson Lab (JLab). It's aimed at mapping the spin and spatial structure of the quark and gluon sea in the nucleon, understanding the emergence of hadronic matter from color charge, and probing the gluon fields in nuclei. A full-acceptance detector is designed to measure the complete final state. Its interaction region allows spectators tagged with high resolution to catch all nuclear and partonic target fragments. The combination of a high luminosity, polarized lepton and ion beams, and detectors fully integrated with the accelerator will allow MEIC to be a unique opportunity to make breakthroughs in the study of nucleon structure and QCD dynamics.

  9. Interactions of aquatic animals with the ORPC OCGen® in Cobscook Bay, Maine: Monitoring behavior change and assessing the probability of encounter with a deployed MHK device

    Energy Technology Data Exchange (ETDEWEB)

    Zydlewski, Gayle Barbin [Univ. of Maine, Orono, ME (United States). School of Marine Sciences; Staines, Garrett [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Viehman, Haley [Acadia Univ., Wolfville, NS (Canada); Shen, Haixue [Louisiana State Univ., Baton Rouge, LA (United States); Altenritter, Megan [Univ. of Maine, Orono, ME (United States)

    2016-10-19

    Commercial viability of the marine hydrokinetic (MHK) energy industry is contingent on numerous and diverse factors. A major factor is the effects deployed devices have on animals. This factor is multi-faceted since it is dependent on the availability of appropriate scientific approaches to detect these effects. One of the animal groups with overlapping distributions of MHK devices are fishes. As such, individual fish behavior is likely to be influenced by the presence and operation of MHK devices. Depending on the scale of deployment there are implications for changes to essential fish habitat and effects that can be explored during deployment of a single device yet most changes are likely to be realized when multiple devices are deployed over large areas. It is not only important to document these effects and examine the need for mitigation, but also determine whether the methods involved can be used within the economic constraints of this nascent industry. The results presented in this report benefit the MHK industry by providing transferrable environmental monitoring approaches for MHK projects, specifically related to the interactions between static and dynamic tidal turbines and fish. In addition, some of the data can be used to generalize conditions (e.g., the temporal periodicity of fish presence in tidal regions and probability of fish encountering a device) at other MHK sites with similar physical conditions and fish assemblages. Ocean Renewable Power Company, LLC (ORPC) deployed and tested a prototype OCGen® tidal module in Cobscook Bay, Maine, in the summer of 2014. University of Maine researchers proposed an approach to inform other researchers, regulators, and industry members of the effects of this deployment on fish. While the approach was specifically applied to the OCGen® module, results are applicable to other pilot projects and inform future array deployments. Research funded under this grant allowed us to quantify fish presence as well as

  10. Encountering Difference

    DEFF Research Database (Denmark)

    Foulkes, Nicol Marie

    2011-01-01

    The Nordic region is famed for its high standards of welfare and public service, labour market flexibility, education, freedom, trust and not least happiness. From a global perspective, in many ways the region occupies a somewhat elite status at the top of the global social ladder, in spite of th...... as a result of the combination of having shared Nordic values, and possessing different levels of human (economic and cultural), social, and erotic capital (Hakim 2010)....

  11. Encounters in cancer treatment

    DEFF Research Database (Denmark)

    Høybye, Mette Terp; Tjørnhøj-Thomsen, Tine

    2014-01-01

    Based on extensive ethnographic material from in-depth interviews with Danish cancer patients after treatment, this study analyzes their stories to explore how interactions with the physician configures and situates a need for rehabilitation. We identify three themes in the illness stories: (1...... by this encounter. The significance of the social encounters in cancer treatment is elucidated through this analysis, and we demonstrate how the need for recognition of the complex effects of cancer on one's life is central to counter experiences of objectification and dehumanization....

  12. The clinical encounter revisited.

    Science.gov (United States)

    Schattner, Ami

    2014-04-01

    The patient-physician encounter is the pivotal starting point of any healthcare delivery, but it is subject to multiple process breakdowns and prevalent suboptimal performance. An overview of the techniques and components of a successful encounter valid for every setting and readily applicable is presented, stressing 7 rules: (1) ensuring optimal environment, tools, and teamwork; (2) viewing each encounter not only as a cognitive/biomedical challenge, but also as a personal one, and a learning opportunity; (3) adopting an attitude of curiosity, concentration, compassion, and commitment, and maintaining a systematic, orderly approach; (4) "simple is beautiful"-making the most of the basic clinical data and their many unique advantages; (5) minding "the silent dimension"-being attentive to the patient's identity and emotions; (6) following the "Holy Trinity" of gathering all information, consulting databases/colleagues, and tailoring gained knowledge to the individual patient; and (7) using the encounter as a "window of opportunity" to further the patient's health-not just the major problem, by addressing screening and prevention; promoting health literacy and shared decision-making; and establishing proper follow-up. Barriers to implementation identified can be overcome by continuous educational interventions. A high-quality encounter sets a virtuous cycle of patient-provider interaction and results in increasing satisfaction, adherence, and improved health outcomes.

  13. The role of electrostatic interactions in the process of diffusional encounter and docking of electron transport proteins.

    Science.gov (United States)

    Kovalenko, I B; Khrushchev, S S; Fedorov, V A; Riznichenko, G Yu; Rubin, A B

    2016-05-01

    Electrostatic interaction of plastocyanin and cytochrome f in the process of protein-protein complex formation was investigated by computer simulation methods. It was shown that long-range electrostatic interaction promotes energetically favorable mutual orientation of protein molecules at distances between their cofactors shorter than 5 nm. At distances shorter than 3 nm, these electrostatic interactions lead to a significantly detectable increase in the rate of convergence of the cofactors.

  14. Corotating Interaction Regions at High Latitudes

    Science.gov (United States)

    Kunow, H.; Lee, M. A.; Fisk, L. A.; Forsyth, R. J.; Heber, B.; Horbury, T. S.; Keppler, E.; Kóta, J.; Lou, Y.-Q.; McKibben, R. B.; Paizis, C.; Potgieter, M. S.; Roelof, E. C.; Sanderson, T. R.; Simnett, G. M.; von Steiger, R.; Tsurutani, B. T.; Wimmer-Schweingruber, R. F.; Jokipii, J. R.

    1999-07-01

    Ulysses observed a stable strong CIR from early 1992 through 1994 during its first journey into the southern hemisphere. After the rapid latitude scan in early 1995, Ulysses observed a weaker CIR from early 1996 to mid-1997 in the northern hemisphere as it traveled back to the ecliptic at the orbit of Jupiter. These two CIRs are the observational basis of the investigation into the latitudinal structure of CIRs. The first CIR was caused by an extension of the northern coronal hole into the southern hemisphere during declining solar activity, whereas the second CIR near solar minimum activity was caused by small warps in the streamer belt. The latitudinal structure is described through the presentation of three 26-day periods during the southern CIR. The first at ˜24°S shows the full plasma interaction region including fast and slow wind streams, the compressed shocked flows with embedded stream interface and heliospheric current sheet (HCS), and the forward and reverse shocks with associated accelerated ions and electrons. The second at 40°S exhibits only the reverse shock, accelerated particles, and the 26-day modulation of cosmic rays. The third at 60°S shows only the accelerated particles and modulated cosmic rays. The possible mechanisms for the access of the accelerated particles and the CIR-modulated cosmic rays to high latitudes above the plasma interaction region are presented. They include direct magnetic field connection across latitude due to stochastic field line weaving or to systematic weaving caused by solar differential rotation combined with non-radial expansion of the fast wind. Another possible mechanism is particle diffusion across the average magnetic field, which includes stochastic field line weaving. A constraint on connection to a distant portion of the CIR is energy loss in the solar wind, which is substantial for the relatively slow-moving accelerated ions. Finally, the weaker northern CIR is compared with the southern CIR. It is weak

  15. New Dimensions in Patient–Physician Interaction: Values, Autonomy, and Medical Information in the Patient-Centered Clinical Encounter

    Science.gov (United States)

    Agarwal, Aakash Kumar; Murinson, Beth Brianna

    2012-01-01

    Patient–physician interactions are increasingly influenced by the extraordinary diversification of populations and rapid expansion of medical knowledge that characterize our modern era. By contrast, the patient–physician interaction models currently used to teach medical trainees have little capacity to address these twin challenges. We developed a new model of patient–physician interaction to explicitly address these problems. Historically, models of patient–physician interaction viewed patient autonomy and the manifestation of clearly defined health care-related values as tightly linked, and it was assumed that patients’ medical knowledge was low. Unfortunately, this does not adequately represent patients such as 1) the highly educated non-medical specialist who possesses little familiarity with health-related values but is highly autonomous, and 2) the patient from a non-Western background who may have well-established health care-related values but a low sense of personal independence. In addition, it is evident to us that the assumption that all patients possess little medical knowledge can create alienation between patient and physician, e.g. the well-informed patient with a rare disease. We propose a paradigm that models autonomy, health care-related values formation, and medical knowledge as varying from patient to patient. Four examples of patient types are described within the context of the model based on clinical experience. We believe that adopting this model will have implications for optimizing patient–physician interactions and teaching about patient-centered care. Further research is needed to identify relevant patient types within this framework and to assess the impact on health care outcomes. PMID:23908841

  16. Social interactions of unfamiliar horses during paired encounters: Effect of pre-exposure on aggression level and so risk of injury

    DEFF Research Database (Denmark)

    Hartmann, Elke; Christensen, Janne Winther; Keeling, Linda J.

    2009-01-01

    investigated two hypotheses: (1) pre-exposure of young horses in neighbouring boxes reduces the frequency of aggressive interactions when the same horses are subsequently put together in a paddock compared to horses without this previous box experience, (2) the occurrence of aggressive behaviour, in particular...... contact aggression in the paddock can be predicted after observing the horses' social interactions in neighbouring boxes. Danish Warmblood mares (n = 20), 2 years old, were kept in two groups of 10 horses. In total, 60 encounters were arranged whereby each horse was confronted pair-wise with six horses...... from the other group, three according to each treatment: treatment I-box (B) and subsequent paddock meeting (BP), and treatment II-only paddock meeting (P). Horses met in neighbouring boxes for 5 min and together in the same paddock for 10 min. The frequencies of aggressive and non...

  17. ecological region interaction in Bonsmara cattle

    African Journals Online (AJOL)

    1999-03-20

    Mar 20, 1999 ... This hypothesis was examined in the second section of the study. In this ..... true. Based on these results, it may be necessary to perform separate analyses for some regions to .... BERTRAND, J.K., BERGER, P.I. & WILLHAM.

  18. Stripped gas as fuel for newly formed HII regions in the encounter between VCC1249 and M49: a unified picture from NGVS and GUViCS

    CERN Document Server

    Battaia, Fabrizio Arrigoni; Fumagalli, Michele; Boselli, Alessandro; Boissier, Samuel; Cortese, Luca; Heinis, Sebastien; Ferrarese, Laura; Côté, Patrick; Mihos, J Christopher; Cuillandre, Jean Charles; Duc, Pierre-Alain; Durrell, Patrick; Gwyn, Stephen; Jordán, Andrés; Liu, Chengze; Peng, Eric

    2012-01-01

    Context: We study the peculiar interacting galaxy system of VCC1249/M49 located in the core of the Virgo B subcluster. Owing to a recent interaction between the dwarf galaxy VCC1249 and the halo gas of the gE M49, neutral hydrogen has been displaced from the interstellar medium of this dwarf into the Virgo ICM. Observations also reveal multiple compact star-forming regions that are embedded in this HI cloud, with a projected separation up to 13 kpc from VCC1249 in the northwest direction. Aims: Motivated by recent NUV imaging from GUViCS of the VCC1249/M49 system that shows significant ongoing/recent star formation in the compact regions, we aim to constrain the origin of these outlying HII regions with a multi-wavelength approach. Methods: Using deep optical (u, g, i, z) imaging from NGVS and new Halpha imaging obtained at the San Pedro Martir observatory together with Keck long-slit spectroscopy, we characterize the SFR, ages, and metallicity of VCC1249 and its outlying compact regions. Moreover, we analyze...

  19. PROCEEDINGS OF THE WORKSHOP ON LHC INTERACTION REGION CORRECTION SYSTEMS

    Energy Technology Data Exchange (ETDEWEB)

    FISCHER,W.; WEI,J.

    1999-09-02

    The Workshop on LHC Interaction Region Correction Systems was held at Brookhaven National Laboratory, Upton, New York, on 6 and 7 May 1999. It was attended by 25 participants from 5 institutions. The performance of the Large Hadron Collider (LHC) at collision energy is limited by the field quality of the interaction region quadrupoles and dipoles. In three sessions the workshop addressed the field quality of the these magnets, reviewed the principles and efficiency of global and local correction schemes and finalized a corrector layout. The session on Field Quality Issues, chaired by J. Strait (FNAL), discussed the progress made by KEK and FNAL in achieving the best possible field quality in the interaction region quadrupoles. Results of simulation studies were presented that assess the effects of magnetic field errors with simulation studies. Attention was given to the uncertainties in predicting and measuring field errors. The session on Global Correction, chaired by J.-P. Koutchouk (CERN), considered methods of reducing the nonlinear detuning or resonance driving terms in the accelerator one-turn map by either sorting or correcting. The session also discussed the crossing angle dependence of the dynamic aperture and operational experience from LEP. The session on Local Correction, chaired by T. Taylor (CERN), discussed the location, strength and effectiveness of multipole correctors in the interaction regions for both proton and heavy ion operation. Discussions were based on technical feasibility considerations and dynamic aperture requirements. The work on linear corrections in the interaction regions was reviewed.

  20. Symmetric Achromatic Low-Beta Collider Interaction Region Design Concept

    Energy Technology Data Exchange (ETDEWEB)

    Morozov, Vasiliy S. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Derbenev, Yaroslav S. [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Lin, Fanglei [Thomas Jefferson National Accelerator Facility, Newport News, VA (United States); Johnson, Rolland P. [Muons, Inc., Batavia, IL (United States)

    2013-01-01

    We present a new symmetry-based concept for an achromatic low-beta collider interaction region design. A specially-designed symmetric Chromaticity Compensation Block (CCB) induces an angle spread in the passing beam such that it cancels the chromatic kick of the final focusing quadrupoles. Two such CCB?s placed symmetrically around an interaction point allow simultaneous compensation of the 1st-order chromaticities and chromatic beam smear at the IP without inducing significant 2nd-order aberrations. We first develop an analytic description of this approach and explicitly formulate 2nd-order aberration compensation conditions at the interaction point. The concept is next applied to develop an interaction region design for the ion collider ring of an electron-ion collider. We numerically evaluate performance of the design in terms of momentum acceptance and dynamic aperture. The advantages of the new concept are illustrated by comparing it to the conventional distributed-sextupole chromaticity compensation scheme.

  1. Symmetric achromatic low-beta collider interaction region design concept

    CERN Document Server

    Morozov, V S; Lin, F; Johnson, R P

    2012-01-01

    We present a new symmetry-based concept for an achromatic low-beta collider interaction region design. A specially-designed symmetric Chromaticity Compensation Block (CCB) induces an angle spread in the passing beam such that it cancels the chromatic kick of the final focusing quadrupoles. Two such CCBs placed symmetrically around an interaction point allow simultaneous compensation of the 1st-order chromaticities and chromatic beam smear at the IP without inducing significant 2nd-order aberrations to the particle trajectory. We first develop an analytic description of this approach and explicitly formulate 2nd-order aberration compensation conditions at the interaction point. The concept is next applied to develop an interaction region design for the ion collider ring of an electron-ion collider. We numerically evaluate performance of the design in terms of momentum acceptance and dynamic aperture. The advantages of the new concept are illustrated by comparing it to the conventional distributed-sextupole chr...

  2. Customer-to-customer roles and impacts in service encounters

    OpenAIRE

    Lee, Linda

    2016-01-01

    This thesis investigates customer-to-customer roles and impacts in the context of service encounters. This topic is studied from two angles: customer interactions during group service encounters and customer perceptions post service encounters. The first angle is a focus on group service encounters that addresses the lack of research on customer-to-customer interactions that occur in customer-to-customer interaction-intensive contexts. These are contexts where the interactions between custome...

  3. Customer-to-customer roles and impacts in service encounters

    OpenAIRE

    Lee, Linda

    2016-01-01

    This thesis investigates customer-to-customer roles and impacts in the context of service encounters. This topic is studied from two angles: customer interactions during group service encounters and customer perceptions post service encounters. The first angle is a focus on group service encounters that addresses the lack of research on customer-to-customer interactions that occur in customer-to-customer interaction-intensive contexts. These are contexts where the interactions between custome...

  4. Interactive 3D computer model of the human corneolimbal region

    DEFF Research Database (Denmark)

    Molvaer, Rikke Kongshaug; Andreasen, Arne; Heegaard, Steffen;

    2013-01-01

    in the superior limbal region and one LEC, six LCs and 12 FSPs in the inferior limbal region. Only few LECs, LCs and FSPs were localized nasally and temporally. CONCLUSION: Interactive 3D models are a powerful tool that may help to shed more light on the existence and spatial localization of the different stem......PURPOSE: This study aims to clarify the existence of and to map the localization of different proposed stem cell niches in the corneal limbal region. MATERIALS AND METHODS: One human eye was cut into 2200 consecutive sections. Every other section was stained with haematoxylin and eosin, digitized...... in the limbal region: limbal epithelial crypts (LECs), limbal crypts (LCs) and focal stromal projections (FSPs). In all, eight LECs, 25 LCs and 105 FSPs were identified in the limbal region. The LECs, LCs and FSPs were predominantly located in the superior limbal region with seven LECs, 19 LCs and 93 FSPs...

  5. [To encounter oneself, to encounter each other].

    Science.gov (United States)

    Kogan, A A

    1982-06-01

    The purpose of this article is to elucidate the concept of encounter within the realm of psycotherapy, either individual or group, with its inter and intrapersonal connotations. Its importance is emphasized and means for its achievement are suggested. A double course is followed to attain this end: on the one hand, the tracing of the concept in the contemporary philosophic anthropology (the positions of M. Buber and of K. Jaspers are briefly examined) and in the views of several psychotherapists who have placed it as a significant issue in their treatments (the therapists considered are K. Binswanger, C. Rogers, J. L. Moreno and E. Pichon-Rivière), and on the other hand, some clinical means, and very special attitudes, are indicated as particularly favourable for the promotion of that enlargement of subjectivity leading to the encounter of one-self as well as the other person. Some fragments of sessions are presented demonstrating that in general the "how" of the attitude prevailing in the therapeutic relation is more effective than the "what" of the specific technical resources employed. However, some of these are commendable as a more direct way to bring about the experience of encounter. This leads me to psychodrama, with its techniques of the double, the inversion of roles, the mirror, and most of all with the general group sharing that closes the sessions, and to the gestalt methods, which involve in many instances physical contacts with other people, with the precise object of achieving a maximum insight, or, in the already classical expression, awareness, which is basically an encounter with oneself. Implicit in all the above considerations lies the conviction that man must share his existence with others not only for biological reasons; it is an indispensable requirement for his full development as an individual, a requirement for being himself. If one of the goals of psychological treatments is to promote personal growth and proximity to oneself, an

  6. People, soil and manioc interactions in the upper Amazon region

    NARCIS (Netherlands)

    Peña Venegas, C.P.

    2015-01-01

    Abstract Clara Patricia Peña Venegas (2015). People, soil and manioc interactions in the upper Amazon region. PhD thesis, Wageningen University, The Netherlands, with summaries in English and Dutch, 210 pp. The presence of anthropogenic soils, or Amazonian Dark

  7. People, soil and manioc interactions in the upper Amazon region

    NARCIS (Netherlands)

    Peña Venegas, C.P.

    2015-01-01

    Abstract Clara Patricia Peña Venegas (2015). People, soil and manioc interactions in the upper Amazon region. PhD thesis, Wageningen University, The Netherlands, with summaries in English and Dutch, 210 pp. The presence of anthropogenic soils, or Amazonian Dark   Ea

  8. Membrane interacting regions of Dengue virus NS2A protein.

    Science.gov (United States)

    Nemésio, Henrique; Villalaín, José

    2014-08-28

    The Dengue virus (DENV) NS2A protein, essential for viral replication, is a poorly characterized membrane protein. NS2A displays both protein/protein and membrane/protein interactions, yet neither its functions in the viral cycle nor its active regions are known with certainty. To highlight the different membrane-active regions of NS2A, we characterized the effects of peptides derived from a peptide library encompassing this protein's full length on different membranes by measuring their membrane leakage induction and modulation of lipid phase behavior. Following this initial screening, one region, peptide dens25, had interesting effects on membranes; therefore, we sought to thoroughly characterize this region's interaction with membranes. This peptide presents an interfacial/hydrophobic pattern characteristic of a membrane-proximal segment. We show that dens25 strongly interacts with membranes that contain a large proportion of lipid molecules with a formal negative charge, and that this effect has a major electrostatic contribution. Considering its membrane modulating capabilities, this region might be involved in membrane rearrangements and thus be important for the viral cycle.

  9. The FCC-ee Interaction Region Magnet Design

    CERN Document Server

    Koratzinos, M; Bogomyagkov, A; Sinyatkin, S; Benedikt, M; Holzer, B; van Nugteren, J; Zimmermann, F; Oide, K

    2016-01-01

    The design of the region close to the interaction point of the FCC-ee experiments is especially challenging. The beams collide at an angle (+-15 mrad) in the high-field region of the detector solenoid. Moreover, the very low vertical beta_y* of the machine necessitates that the final focusing quadrupoles have a distance from the IP (L*) of around 2 m and therefore are inside the main detector solenoid. The beams should be screened from the effect of the detector magnetic field, and the emittance blow-up due to vertical dispersion in the interaction region should be minimized, while leaving enough space for detector components. Crosstalk between the two final focus quadrupoles, only about 6 cm apart at the tip, should also be minimized.

  10. Synchrotron Radiation in eRHIC Interaction Region

    CERN Document Server

    Beebe-Wang, Joanne; Montag, Christoph; Rondeau, Daniel J; Surrow, Bernd

    2005-01-01

    The eRHIC currently under study at BNL consists of an electron storage ring added to the existing RHIC complex. The interaction region of this facility has to provide the required low-beta focusing while accommodating the synchrotron radiation generated by beam separation close to the interaction point. In the current design, the synchrotron radiation caused by 10GeV electrons bent by low-beta triplet magnets will be guided through the interaction region and dumped 5m downstream. However, it is unavoidable to stop a fraction of the photons at the septum where the electron and ion vacuum system are separated. In order to protect the septum and minimize the backward scattering of the synchrotron radiation, an absorber and collimation system will be employed. In this paper, we first present the overview of the current design of the eRHIC interaction region with special emphasis on the synchrotron radiation. Then the initial design of the absorber and collimation system, including their geometrical and physical p...

  11. Dental Encounter System (DES)

    Data.gov (United States)

    Department of Veterans Affairs — Dental Encounter System (DES) is an automated health care application designed to capture critical data about the operations of VA Dental Services. Information on...

  12. THE NUCLEAR ENCOUNTER PROBABILITY

    NARCIS (Netherlands)

    SMULDERS, PJM

    1994-01-01

    This Letter dicusses the nuclear encounter probability as used in ion channeling analysis. A formulation is given, incorporating effects of large beam angles and beam divergence. A critical examination of previous definitions is made.

  13. Beyond the Embodied Digital Service Encounter

    DEFF Research Database (Denmark)

    Sørensen, Jannick Kirk

    2017-01-01

    When a digital service encounter develops differently than anticipated, the client becomes a user. This transformation reveals the ambiguous nature of digital service encounter being neither well-functioning tools, nor having the same sensitivity to and tolerance for service failures as in human...... service encounters. Through the case-study of a service failure and subsequent co-creation of the service recovery, this chapter introduces and unfolds the concept of 'cognitively dominated service encounters'. This category is suggested to supplement and criticise Paul Dourish's (2001) concept...... of Embodied Interaction. With a micro analysis of the interaction in this service journey, we identify the need for a category of knowledge intensive service encounters that acknowledge both the complexity of the service provided, but also the constraints and possibilities in the digital design material....

  14. Interaction region design and auxiliary detector systems for an EIC

    Directory of Open Access Journals (Sweden)

    Petti R.

    2016-01-01

    Full Text Available There are a number of exciting physics opportunities at a future electron-ion collider facility. One possible design for such a facility is eRHIC, where the current RHIC facility located at Brookhaven National Lab would be transformed into an electron-ion collider. It is imperative for a seamless integration of auxiliary detector systems into the interaction region design to have a machine that meets the needs for the planned physics analyses, as well as take into account the space constraints due to the tunnel geometry and the necessary beam line elements. In this talk, we describe the current ideas for integrating a luminosity detector, electron polarimeter, roman pots, and a low Q2-tagger into the interaction region for eRHIC.

  15. Privacy encounters in Teledialogue

    DEFF Research Database (Denmark)

    Andersen, Lars Bo; Bøge, Ask Risom; Danholt, Peter

    2016-01-01

    Privacy is a major concern when new technologies are introduced between public authorities and private citizens. What is meant by privacy, however, is often unclear and contested. Accordingly, this article utilises grounded theory to study privacy empirically in the research and design project...... Teledialogue aimed at introducing new ways for public case managers and placed children to communicate through IT. The resulting argument is that privacy can be understood as an encounter, that is, as something that arises between implicated actors and entails some degree of friction and negotiation....... An argument which is further qualified through the philosophy of Gilles Deleuze. The article opens with a review of privacy literature before continuing to present privacy as an encounter with five different foci: what technologies bring into the encounter; who is related to privacy by implication; what...

  16. Brief encounter networks

    CERN Document Server

    Kostakos, Vassilis; Penn, Alan

    2007-01-01

    Many complex human and natural phenomena can usefully be represented as networks describing the relationships between individuals. While these relationships are typically intermittent, previous research has used network representations that aggregate the relationships at discrete intervals. However, such an aggregation discards important temporal information, thus inhibiting our understanding of the networks dynamic behaviour and evolution. We have recorded patterns of human urban encounter using Bluetooth technology thus retaining the temporal properties of this network. Here we show how this temporal information influences the structural properties of the network. We show that the temporal properties of human urban encounter are scale-free, leading to an overwhelming proportion of brief encounters between individuals. While previous research has shown preferential attachment to result in scale-free connectivity in aggregated network data, we found that scale-free connectivity results from the temporal prope...

  17. Strange culinary encounters:

    DEFF Research Database (Denmark)

    Leer, Jonatan; Kjær, Katrine Meldgaard

    2015-01-01

    the ‘other’ food cultures in these programs, paying special attention to how the encounter with the local Indian and Italian is imagined to be a gateway to an authentic and/or primitive experience. Our main argument is that despite Jamie and Gordon's ‘noble’ intentions and their ‘enlightened’ cosmopolitan......In this article, we examine the ways in which the encountering of 'other' food cultures is played out in the two travelogue cooking shows Gordon's Great Escape and Jamie's Italian Escape. We investigate how the two protagonist chefs Jamie Oliver and Gordon Ramsay imagine, meet and evaluate...

  18. Communication in medical encounters.

    NARCIS (Netherlands)

    Bensing, J.M.; Verhaak, P.F.M.

    2004-01-01

    The aim of this chapter is to provide a theoretical and empirical basis for the concept of communication as the core instrument in the medical encounter. Adequate communication, embedded in a warm and caring relationship, has always been recognized as essential to the concept of good doctoring, but

  19. Global Diabetes Encounters

    DEFF Research Database (Denmark)

    Juul Nielsen, Annegrete; Langstrup, Henriette

    2014-01-01

    As already recognized, though little theorized within International Relations, the capacity of technology to ensure the achievement of preset policy goals is often grossly overrated. Drawing on Science and Technology Studies, this chapter proposes a lens to investigate global encounters, which ta...

  20. Global Diabetes Encounters

    DEFF Research Database (Denmark)

    Juul, Annegrete; Langstrup, Henriette

    2014-01-01

    As already recognized, though little theorized within International Relations, the capacity of technology to ensure the achievement of preset policy goals is often grossly overrated. Drawing on Science and Technology Studies, this chapter proposes a lens to investigate global encounters, which ta...

  1. Global Diabetes Encounters

    DEFF Research Database (Denmark)

    Juul Nielsen, Annegrete; Langstrup, Henriette

    2014-01-01

    As already recognized, though little theorized within International Relations, the capacity of technology to ensure the achievement of preset policy goals is often grossly overrated. Drawing on Science and Technology Studies, this chapter proposes a lens to investigate global encounters, which take...

  2. Strange culinary encounters:

    DEFF Research Database (Denmark)

    Leer, Jonatan; Kjær, Katrine Meldgaard

    2015-01-01

    In this article, we examine the ways in which the encountering of 'other' food cultures is played out in the two travelogue cooking shows Gordon's Great Escape and Jamie's Italian Escape. We investigate how the two protagonist chefs Jamie Oliver and Gordon Ramsay imagine, meet and evaluate the ‘o...

  3. A Lakatosian Encounter

    Science.gov (United States)

    Chick, Helen

    2010-01-01

    There is much to be learned and pondered by reading "Proofs and Refutations," by Imre Lakatos. It highlights the importance of mathematical definitions, and how definitions evolve to capture the essence of the object they are defining. It also provides an exhilarating encounter with the ups and downs of the mathematical reasoning process, where…

  4. Nonlinear Interactions within the D-Region Ionosphere

    Science.gov (United States)

    Moore, Robert

    2016-07-01

    This paper highlights the best results obtained during D-region modification experiments performed by the University of Florida at the High-frequency Active Auroral Research Program (HAARP) observatory between 2007 and 2014. Over this period, we saw a tremendous improvement in ELF/VLF wave generation efficiency. We identified methods to characterize ambient and modified ionospheric properties and to discern and quantify specific types of interactions. We have demonstrated several important implications of HF cross-modulation effects, including "Doppler Spoofing" on HF radio waves. Throughout this talk, observations are compared with the predictions of an ionospheric HF heating model to provide context and guidance for future D-region modification experiments.

  5. Encounters with immigrant customers

    DEFF Research Database (Denmark)

    Mygind, Anna; Espersen, Sacha; Nørgaard, Lotte Stig

    2013-01-01

    OBJECTIVES: To explore the challenges that Danish community pharmacy staff encounter when serving non-Western immigrant customers. Special attention was paid to similarities and differences between the perceptions of pharmacists and pharmacy assistants. METHODS: A questionnaire was distributed...... to one pharmacist and one pharmacy assistant employed at each of the 55 community pharmacies located in the five local councils in Denmark with the highest number of immigrant inhabitants. KEY FINDINGS: The total response rate was 76% (84/110). Most respondents found that the needs of immigrant customers...... companies. CONCLUSIONS: Community pharmacy staff report poorer quality in their encounters with immigrant customers, including sub-optimal counselling and frequent use of under-aged children as interpreters. Our study also reveals certain differences across personnel groups, which may be explained...

  6. Encountering the Everyday

    DEFF Research Database (Denmark)

    , as sociologists, need to take everyday life seriously. This is the objective of this book. Encountering the Everyday: An Introduction to the Sociologies of the Unnoticed provides the first comprehensive and updated globally applicable introduction to everyday life sociology for many years. The contributors...... present the theoretical, conceptual and methodological groundwork, historical developments and distinct perspectives of a variety of everyday life traditions and relate these to and exemplify them through actual empirical research. Encountering the Everyday contains introductions to ‘classical' everyday...... life traditions such as Chicago sociology, phenomenology, American pragmatism, symbolic interactionism, existentialism and critical everyday life sociologies, but also to the later developments by Erving Goffman, French everyday life thinkers, the ethnomethodologists, conversation analysts...

  7. Suprathermal helium associated with corotating interaction regions: A case study

    Science.gov (United States)

    Yu, J.; Berger, L.; Wimmer-Schweingruber, R. F.; Hilchenbach, M.; Kallenbach, R.; Klecker, B.; Guo, J.

    2016-03-01

    Enhancements of suprathermal particles observed at 1AU often can be related to Corotating Interaction Regions (CIRs). The compression regions associated with CIRs and their driven shocks which typically form at a few AU distance to the Sun can efficiently accelerate particles. If accelerated at the trailing edge of a CIR these particles can travel sunward along the ambient magnetic field and thus enhanced fluxes can be observed even if the acceleration region has passed over the spacecraft. We have analysed a CIR that has been observed at L1 by ACE/SWICS and SOHO/CELIAS/STOF on days 207 and 208 in 2003. The combination of SWICS and STOF data allowed us to study suprathermal Helium ranging from its onset at solar wind bulk energies up to 330 keV/nuc. Here we present our results for the temporal evolution of the flux, energy spectra and the He+/He++ ratio. In particular we present observational evidence for a turnover of the energy spectra at lower energies after the CIR passage which has been theoretically predicted but never been observed so far.

  8. Power Saving Optimization for Linear Collider Interaction Region Parameters

    Energy Technology Data Exchange (ETDEWEB)

    Seryi, Andrei; /SLAC

    2009-10-30

    Optimization of Interaction Region parameters of a TeV energy scale linear collider has to take into account constraints defined by phenomena such as beam-beam focusing forces, beamstrahlung radiation, and hour-glass effect. With those constraints, achieving a desired luminosity of about 2E34 would require use of e{sup +}e{sup -} beams with about 10 MW average power. Application of the 'travelling focus' regime may allow the required beam power to be reduced by at least a factor of two, helping reduce the cost of the collider, while keeping the beamstrahlung energy loss reasonably low. The technique is illustrated for the 500 GeV CM parameters of the International Linear Collider. This technique may also in principle allow recycling the e{sup +}e{sup -} beams and/or recuperation of their energy.

  9. Interactive Building Design Space Exploration Using Regionalized Sensitivity Analysis

    DEFF Research Database (Denmark)

    Jensen, Rasmus Lund; Maagaard, Steffen; Østergård, Torben

    2017-01-01

    Monte Carlo simulations combined with regionalized sensitivity analysis provide the means to explore a vast, multivariate design space in building design. Typically, sensitivity analysis shows how the variability of model output relates to the uncertainties in models inputs. This reveals which...... in combination with the interactive parallel coordinate plot (PCP). The latter is an effective tool to explore stochastic simulations and to find high-performing building designs. The proposed methods help decision makers to focus their attention to the most important design parameters when exploring...... a multivariate design space. As case study, we consider building performance simulations of a 15.000 m² educational centre with respect to energy demand, thermal comfort, and daylight....

  10. 120-mm superconducting quadrupole for interaction regions of hadron colliders

    CERN Document Server

    Zlobin, A V; Mokhov, N V; Novitski, I

    2012-01-01

    Magnetic and mechanical designs of a Nb3Sn quadrupole magnet with 120-mm aperture suitable for interaction regions of hadron colliders are presented. The magnet is based on a two-layer shell-type coil and a cold iron yoke. Special spacers made of a low-Z material are implemented in the coil mid-planes to reduce the level of radiation heat deposition and radiation dose in the coil. The quadrupole mechanical structure is based on aluminum collars supported by an iron yoke and a stainless steel skin. Magnet parameters including maximum field gradient and field harmonics, Nb3Sn coil pre-stress and protection at the operating temperatures of 4.5 and 1.9 K are reported. The level and distribution of radiation heat deposition in the coil and other magnet components are discussed.

  11. The task dependent interaction of the deactivation regions

    Institute of Scientific and Technical Information of China (English)

    ZHANG Ye; FENG ShiGang; FENG HongBo; DONG Feng; TANG YiYuan

    2008-01-01

    Although deactivation has been found frequently in former functional brain imaging researches, only recently has it become a focus of systematic study because of its not well understood physiological mechanism. However, most of the researches concentrated on the brain areas that would present de-activation, and, to our knowledge, the deactivation connectivity between these brain areas during the cognitive tasks has rarely been reported in literature. In this work, using the functional connectivity method WlCA (within-condition interregional covariance analysis), we analyzed the deactivations in two different cognitive tasks-symbol orientation and number comparison. The results revealed de-activations in the posterior cingulate, precuneus, anterior cingulate and prefrontal cortex in both tasks. However, the interaction between the deactivated regions shows many differences. Our result further indicates that the potential implication of special deactivation connectivity may be related to the dif-ferent task or attention resource. Further research is needed to clarify the exact reason.

  12. The FIRST experiment: interaction region and MAPS vertex detector

    Energy Technology Data Exchange (ETDEWEB)

    Spiriti, E. [INFN, Sezione di Roma Tre, Via della Vasca Navale 84, I-00146 Roma (Italy); De Napoli, M.; Romano, F. [INFN, Laboratori Nazionali del Sud, Via S. Sofia 62, I-95125 Catania (Italy)

    2011-06-15

    The improvement of the precision of the measurement of the nuclear cross-section, in order to fulfill the requirements of the actual Monte Carlo simulations for hadrontherapy and space radioprotection, is the main goal of the FIRST experiment. After a brief introduction on the treatment planning in hadrontherapy, this paper describes main characteristics and components of the experiment. The features of the interaction region detectors and their main needs (low material budget, high angular coverage, two tracks resolution and large trigger rate) are discussed. Special emphasis is devoted in discussing the new silicon pixel vertex detector, in particular its new developed data acquisition and its characterization with the first test results obtained with a prototype of the detector.

  13. The FIRST experiment: interaction region and MAPS vertex detector

    Science.gov (United States)

    Spiriti, E.; de Napoli, M.; Romano, F.; FIRST Collaboration

    2011-06-01

    The improvement of the precision of the measurement of the nuclear cross-section, in order to fulfill the requirements of the actual Monte Carlo simulations for hadrontherapy and space radioprotection, is the main goal of the FIRST experiment. After a brief introduction on the treatment planning in hadrontherapy, this paper describes main characteristics and components of the experiment. The features of the interaction region detectors and their main needs (low material budget, high angular coverage, two tracks resolution and large trigger rate) are discussed. Special emphasis is devoted in discussing the new silicon pixel vertex detector, in particular its new developed data acquisition and its characterization with the first test results obtained with a prototype of the detector.

  14. LHC interaction region quadrupole cryostat design and fabrication

    CERN Document Server

    Nicol, T H; Huang, Y; Page, Thomas M

    2002-01-01

    The cryostat of a Large Hadron Collider (LHC) Interaction Region (IR) quadrupole magnet consists of all components of the inner triplet except the magnet assembly itself. It serves to support the magnet accurately and reliably within the vacuum vessel, to house all required cryogenic piping, and to insulate the cold mass from heat radiated and conducted from the environment. It must function reliably during storage, shipping and handling, normal magnet operation, quenches, and seismic excitations, and must be able to be manufactured at low cost. The major components of the cryostat are the vacuum vessel, thermal shield, multilayer insulation system, cryogenic piping, and suspension system. The overall design of a cryostat for superconducting accelerator magnets requires consideration of fluid flow, proper selection of materials for their thermal and structural performance at both ambient and operating temperature, and knowledge of the environment to which the magnets will be subjected over the course of their...

  15. Interactive retinal blood flow analysis of the macular region.

    Science.gov (United States)

    Tian, Jing; Somfai, Gábor Márk; Campagnoli, Thalmon R; Smiddy, William E; Debuc, Delia Cabrera

    2016-03-01

    The study of retinal hemodynamics plays an important role to understand the onset and progression of diabetic retinopathy. In this work, we developed an interactive retinal analysis tool to quantitatively measure the blood flow velocity (BFV) and blood flow rate (BFR) in the macular region using the Retinal Function Imager (RFI). By employing a high definition stroboscopic fundus camera, the RFI device is able to assess retinal blood flow characteristics in vivo. However, the measurements of BFV using a user-guided vessel segmentation tool may induce significant inter-observer differences and BFR is not provided in the built-in software. In this work, we have developed an interactive tool to assess the retinal BFV and BFR in the macular region. Optical coherence tomography data was registered with the RFI image to locate the fovea accurately. The boundaries of the vessels were delineated on a motion contrast enhanced image and BFV was computed by maximizing the cross-correlation of pixel intensities in a ratio video. Furthermore, we were able to calculate the BFR in absolute values (μl/s). Experiments were conducted on 122 vessels from 5 healthy and 5 mild non-proliferative diabetic retinopathy (NPDR) subjects. The Pearson's correlation of the vessel diameter measurements between our method and manual labeling on 40 vessels was 0.984. The intraclass correlation (ICC) of BFV between our proposed method and built-in software was 0.924 and 0.830 for vessels from healthy and NPDR subjects, respectively. The coefficient of variation between repeated sessions was reduced significantly from 22.5% to 15.9% in our proposed method (p<0.001). Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Aerosol-cloud interactions from urban, regional to global scales

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Yuan [California Institute of Technology, Pasadena, CA (United States). Seismological Lab.

    2015-10-01

    The studies in this dissertation aim at advancing our scientific understandings about physical processes involved in the aerosol-cloud-precipitation interaction and quantitatively assessing the impacts of aerosols on the cloud systems with diverse scales over the globe on the basis of the observational data analysis and various modeling studies. As recognized in the Fifth Assessment Report by the Inter-government Panel on Climate Change, the magnitude of radiative forcing by atmospheric aerosols is highly uncertain, representing the largest uncertainty in projections of future climate by anthropogenic activities. By using a newly implemented cloud microphysical scheme in the cloud-resolving model, the thesis assesses aerosol-cloud interaction for distinct weather systems, ranging from individual cumulus to mesoscale convective systems. This thesis also introduces a novel hierarchical modeling approach that solves a long outstanding mismatch between simulations by regional weather models and global climate models in the climate modeling community. More importantly, the thesis provides key scientific solutions to several challenging questions in climate science, including the global impacts of the Asian pollution. As scientists wrestle with the complexities of climate change in response to varied anthropogenic forcing, perhaps no problem is more challenging than the understanding of the impacts of atmospheric aerosols from air pollution on clouds and the global circulation.

  17. Geoeffectiveness of Stream Interaction Regions during 2007-2008

    Science.gov (United States)

    Sanchez-Garcia, Elsa; Aguilar-Rodriguez, Ernesto; Ontiveros, Veronica

    2016-07-01

    The Stream Interaction Regions (SIRs) are generated in the interplanetary medium when a fast solar wind stream overtakes a slower one. If these large-scale phenomena interact with the Earth's magnetosphere they can give rise to geomagnetic storms (GSs). In this study we analyze the degree of geoeffectiveness of 20 events that were generated by SIRs. The events were observed during the 2007-2008 period that comprising the extended downward phase of solar cycle 23. The degree of geoeffectivity is measured using magnetic indices from different latitudes: PCN (Polar cap north), PCS (polar cap south), AA (antipodal amplitude), AE (Auroral Electrojet), Kp (estimated global index) and Dst (Disturbance storm time). We discuss some results on the correlation of these magnetic indices with the characteristics of shocks associated with the SIRs observed by STEREO-A/B, WIND and ACE spacecraft. All the 20 SIRs events generated GSs with Dst values in ranging from -86 nT up to -12 nT. Moreover, 6 out of the 20 events presented storm sudden commencement (SSC). We also discuss on the characteristics of the SIR-associated shocks and the intensity of the GSs.

  18. Sequencing the hypervariable regions of human mitochondrial DNA using massively parallel sequencing: Enhanced data acquisition for DNA samples encountered in forensic testing.

    Science.gov (United States)

    Davis, Carey; Peters, Dixie; Warshauer, David; King, Jonathan; Budowle, Bruce

    2015-03-01

    Mitochondrial DNA testing is a useful tool in the analysis of forensic biological evidence. In cases where nuclear DNA is damaged or limited in quantity, the higher copy number of mitochondrial genomes available in a sample can provide information about the source of a sample. Currently, Sanger-type sequencing (STS) is the primary method to develop mitochondrial DNA profiles. This method is laborious and time consuming. Massively parallel sequencing (MPS) can increase the amount of information obtained from mitochondrial DNA samples while improving turnaround time by decreasing the numbers of manipulations and more so by exploiting high throughput analyses to obtain interpretable results. In this study 18 buccal swabs, three different tissue samples from five individuals, and four bones samples from casework were sequenced at hypervariable regions I and II using STS and MPS. Sample enrichment for STS and MPS was PCR-based. Library preparation for MPS was performed using Nextera® XT DNA Sample Preparation Kit and sequencing was performed on the MiSeq™ (Illumina, Inc.). MPS yielded full concordance of base calls with STS results, and the newer methodology was able to resolve length heteroplasmy in homopolymeric regions. This study demonstrates short amplicon MPS of mitochondrial DNA is feasible, can provide information not possible with STS, and lays the groundwork for development of a whole genome sequencing strategy for degraded samples.

  19. SUMO meets meiosis: an encounter at the synaptonemal complex: SUMO chains and sumoylated proteins suggest that heterogeneous and complex interactions lie at the centre of the synaptonemal complex.

    Science.gov (United States)

    Watts, Felicity Z; Hoffmann, Eva

    2011-07-01

    Recent discoveries have identified the small ubiquitin-like modifier (SUMO) as the potential 'missing link' that could explain how the synaptonemal complex (SC) is formed during meiosis. The SC is important for a variety of chromosome interactions during meiosis and appears ladder-like. It is formed when 'axes' of the two homologous chromosomes become connected by the deposition of transverse filaments, forming the steps of the ladder. Although several components of axial and transverse elements have been identified, how the two are connected to form the SC has remained an enigma. Recent discoveries suggest that SUMO modification underlies protein-protein interactions within the SC of budding yeast. The versatility of SUMO in regulating protein-protein interactions adds an exciting new dimension to our understanding of the SC and suggests that SCs are not homogenous structures throughout the nucleus. We propose that this heterogeneity may allow differential regulation of chromosome structure and function.

  20. Awkward Encounters and Ethnography

    DEFF Research Database (Denmark)

    Koning, Juliette; Ooi, Can-Seng

    2013-01-01

    Purpose – Researchers rarely present accounts of their awkward encounters in ethnographies. Awkwardness, however, does matter and affects the ethnographic accounts we write and our understanding of social situations. The purpose is to bring these hidden sides of organizational ethnography...... (Koning), and visiting an artist village in China (Ooi). Based on analysing their awkwardness, and in the context of a critical assessment of the reflexive turn in ethnography, the authors propose a more inclusive reflexivity. The paper ends with formulating several points supportive of reaching inclusive...

  1. The Idealized Cultural Encounter

    DEFF Research Database (Denmark)

    Christiansen, Lene Bull

    ). This paper proposes to study cultural encounters which are organised around ideals of cultural difference as a positive social and political force. The Danish People to People NGO Mellemfolkeligt Samvirke (MS) is build around ideals of equality, co-operation, mutuality and solidarity between people...... framework for an investigation into MS’ organisation of what I have termed ‘the idealized cultural encounter’, while also questioning the ways in which ‘culture’ is envisioned in contexts where ‘encounter’ is seen as a positive and desirable force....

  2. The Idealized Cultural Encounter

    DEFF Research Database (Denmark)

    Christiansen, Lene Bull

    ). This paper proposes to study cultural encounters which are organised around ideals of cultural difference as a positive social and political force. The Danish People to People NGO Mellemfolkeligt Samvirke (MS) is build around ideals of equality, co-operation, mutuality and solidarity between people...... framework for an investigation into MS’ organisation of what I have termed ‘the idealized cultural encounter’, while also questioning the ways in which ‘culture’ is envisioned in contexts where ‘encounter’ is seen as a positive and desirable force....

  3. Encounters along Micro-Level Borders: Silence and Metacommunicative Talk in Service Encounter Conversations between Finnish Employment Officials and Immigrants

    OpenAIRE

    Tarja Tanttu

    2014-01-01

    This article examines the interaction between Finnish employment officials and their immigrant clients in service encounter conversations. It employs the concepts of metacommunicative talk, silence, agency and asymmetric interaction situation. Such service encounters between native speakers of Finnish and immigrants going through the integration process and speaking Finnish as their second language constitute situations of institutional interaction, characterised by asymmetry. Asymmetry durin...

  4. [Frequency of encountering markers of viral hepatitis A, B, and C in the aboriginal inhabitants of the northwest region of Siberia].

    Science.gov (United States)

    Netesova, I G; Iaroslavtseva, O A; Dryga, S A; Posukh, O L; Osipova, L P; Bronshteĭn, E L; Zaĭtsev, S A; Netesov, S V

    1995-01-01

    A minor population of Nenets living near the village of Samburg in the Purov District, Tyumen region was screened for serological markers of virus hepatitides A, B, and C (VHA, HVB, and HVC, respectively). Commercial kits manufactured by VectorBest JSC, Russia, were used. All the tested sera contained antiHVA IgG; IgM antibodies to VHA were detected in none of the tested sera, anti-HVC IgG were found in 1 (0.93%) serum, antiHBc IgG in 11 (10.2%), and HBsAg was detected in 2 (1.85%) serum samples. The sera positive by antiHBc IgG and HBsAg were tested for DNA by the polymerase chain reaction. HVB DNA was found in two HBsAg-positive sera with the HBsAg subtype determined as "non ad".

  5. Encounter-based worms: Analysis and Defense

    CERN Document Server

    Tanachaiwiwat, Sapon

    2007-01-01

    Encounter-based network is a frequently-disconnected wireless ad-hoc network requiring immediate neighbors to store and forward aggregated data for information disseminations. Using traditional approaches such as gateways or firewalls for deterring worm propagation in encounter-based networks is inappropriate. We propose the worm interaction approach that relies upon automated beneficial worm generation aiming to alleviate problems of worm propagations in such networks. To understand the dynamic of worm interactions and its performance, we mathematically model worm interactions based on major worm interaction factors including worm interaction types, network characteristics, and node characteristics using ordinary differential equations and analyze their effects on our proposed metrics. We validate our proposed model using extensive synthetic and trace-driven simulations. We find that, all worm interaction factors significantly affect the pattern of worm propagations. For example, immunization linearly decrea...

  6. Exploring Digital Encounters in the Public Arena

    Science.gov (United States)

    Schieck, Ava Fatah Gen.; Kostakos, Vassilis; Penn, Alan

    In this chapter, we explore the types of encounters that technology enables. We consider the differences between digital and nondigital encounters through two pilot studies carried out in the city of Bath, United Kingdom. We investigate how technology can be appropriated for shared interactions that support conscious (or unconscious) social encounters, and highlight the importance of space and the role of place in providing temporal and spatial mechanisms facilitating different types of shared encounters. Here, we apply a method based on intervention through "sensing and projecting" Bluetooth names and digital identity in the public arena, and describe initial observations about people's reaction toward the projection of their Bluetooth names in public. In particular, we note the significance of constructing socially meaningful relations between people mediated by these technologies. We discuss initial results and outline issues raised in detail before finally describing the ongoing work.

  7. Climate-aerosol interactions over the Mediterranean region: a regional coupled modelling approach

    Science.gov (United States)

    Nabat, Pierre; Somot, Samuel; Mallet, Marc

    2015-04-01

    The Mediterranean basin is affected by numerous and various aerosols which have a high spatio-temporal variability. These aerosols directly interact with solar and thermal radiation, and indirectly with clouds and atmospheric dynamics. Therefore they can have an important impact on the regional climate. This work, located at the boundary between the ChArMEx and HyMeX programs, considers a coupled regional modeling approach in order to address the questions of the aerosol-radiation-cloud interactions with regards to the climate variability over the Mediterranean. In order to improve the characterization of Mediterranean aerosols, a new interannual monthly climatology of aerosol optical depth has been developed from a blended product based on both satellite-derived and model-simulated datasets. This dataset, available for every regional climate model over the Mediterranean for the 1979-2012 period, has been built to obtain the best possible estimate of the atmospheric aerosol content for the five species at stake (sulfate, black carbon, organic matter, desert dust and sea salt particles). Simulation ensembles, which have been carried out over the 2003-2009 period with and without aerosols, show a major impact on the regional climate. The seasonal cycle and the spatial patterns of the Mediterranean climate are significantly modified, as well as some specific situations such as the heat wave in July 2006 strengthened by the presence of desert dust particles. The essential role of the Mediterranean sea surface temperature is highlighted, and enables to understand the induced changes on air-sea fluxes and the consequences on regional climate. Oceanic convection is also strengthened by aerosols. In addition, the decrease in anthropogenic aerosols observed for more than thirty years is shown to significantly contribute to the observed Euro-Mediterranean climatic trends in terms of surface radiation and temperature. Besides, an interactive aerosol scheme has been developed

  8. Rings from Close Encounters

    Science.gov (United States)

    Kohler, Susanna

    2016-09-01

    Weve recently discovered narrow sets of rings around two minor planets orbiting in our solar system. How did these rings form? A new study shows that they could be a result of close encounters between the minor planets and giants like Jupiter or Neptune.Unexpected Ring SystemsPositions of the centaurs in our solar system (green). Giant planets (red), Jupiter trojans (grey), scattered disk objects (tan) and Kuiper belt objects (blue) are also shown. [WilyD]Centaurs are minor planets in our solar system that orbit between Jupiter and Neptune. These bodies of which there are roughly 44,000 with diameters larger than 1 km have dynamically unstable orbits that cross paths with those of one or more giant planets.Recent occultation observations of two centaurs, 10199 Chariklo and 2060 Chiron, revealed that these bodies both host narrow ring systems. Besides our four giant planets, Chariklo and Chiron are the only other bodies in the solar system known to have rings. But how did these rings form?Scientists have proposed several models, implicating collisions, disruption of a primordial satellite, or dusty outgassing. But a team of scientists led by Ryuki Hyodo (Paris Institute of Earth Physics, Kobe University) has recently proposed an alternative scenario: what if the rings were formed from partial disruption of the centaur itself, after it crossed just a little too close to a giant planet?Tidal Forces from a GiantHyodo and collaborators first used past studies of centaur orbits to estimate that roughly 10% of centaurs experience close encounters (passing within a distance of ~2x the planetary radius) with a giant planet during their million-year lifetime. The team then performed a series of simulations of close encounters between a giant planet and a differentiated centaur a body in which the rocky material has sunk to form a dense silicate core, surrounded by an icy mantle.Some snapshots of simulation outcomes (click for a closer look!) for different initial states of

  9. Homeless women's experiences of service provider encounters.

    Science.gov (United States)

    Biederman, Donna J; Nichols, Tracy R

    2014-01-01

    Service providers are gatekeepers to health-sustaining services and resources, although little is known about service encounters from the perspective of homeless women. We conducted in-depth semistructured interviews with 15 homeless women to better understand their experiences of service encounters. Using a phenomenological method, 160 significant statements were extracted from participant transcripts; more positive than negative interactions were reported. The 10 themes that emerged fall along a dehumanizing/humanizing continuum primarily separated by the power participants experienced in the interaction and the trust they felt in the service provider. Implications for nursing practice and research are offered.

  10. Government and Governance of Regional Triple Helix Interactions

    Science.gov (United States)

    Danson, Mike; Todeva, Emanuela

    2016-01-01

    This conceptual paper contributes to the discussion of the role of regional government and regional Triple Helix constellations driving economic development and growth within regional boundaries. The impact of regionalism and subsidiarity on regional Triple Helix constellations, and the questions of governmentality, governance and institutional…

  11. Fast global interactive volume segmentation with regional supervoxel descriptors

    Science.gov (United States)

    Luengo, Imanol; Basham, Mark; French, Andrew P.

    2016-03-01

    In this paper we propose a novel approach towards fast multi-class volume segmentation that exploits supervoxels in order to reduce complexity, time and memory requirements. Current methods for biomedical image segmentation typically require either complex mathematical models with slow convergence, or expensive-to-calculate image features, which makes them non-feasible for large volumes with many objects (tens to hundreds) of different classes, as is typical in modern medical and biological datasets. Recently, graphical models such as Markov Random Fields (MRF) or Conditional Random Fields (CRF) are having a huge impact in different computer vision areas (e.g. image parsing, object detection, object recognition) as they provide global regularization for multiclass problems over an energy minimization framework. These models have yet to find impact in biomedical imaging due to complexities in training and slow inference in 3D images due to the very large number of voxels. Here, we define an interactive segmentation approach over a supervoxel space by first defining novel, robust and fast regional descriptors for supervoxels. Then, a hierarchical segmentation approach is adopted by training Contextual Extremely Random Forests in a user-defined label hierarchy where the classification output of the previous layer is used as additional features to train a new classifier to refine more detailed label information. This hierarchical model yields final class likelihoods for supervoxels which are finally refined by a MRF model for 3D segmentation. Results demonstrate the effectiveness on a challenging cryo-soft X-ray tomography dataset by segmenting cell areas with only a few user scribbles as the input for our algorithm. Further results demonstrate the effectiveness of our method to fully extract different organelles from the cell volume with another few seconds of user interaction.

  12. Determination of the CD148-Interacting Region in Thrombospondin-1.

    Directory of Open Access Journals (Sweden)

    Keiko Takahashi

    Full Text Available CD148 is a transmembrane protein tyrosine phosphatase that is expressed in multiple cell types, including vascular endothelial cells and duct epithelial cells. Previous studies have shown a prominent role of CD148 to reduce growth factor signals and suppress cell proliferation and transformation. Further, we have recently shown that thrombospondin-1 (TSP1 serves as a functionally important ligand for CD148. TSP1 has multiple structural elements and interacts with various cell surface receptors that exhibit differing effects. In order to create the CD148-specific TSP1 fragment, here we investigated the CD148-interacting region in TSP1 using a series of TSP1 fragments and biochemical and biological assays. Our results demonstrate that: 1 CD148 binds to the 1st type 1 repeat in TSP1; 2 Trimeric TSP1 fragments that contain the 1st type repeat inhibit cell proliferation in A431D cells that stably express wild-type CD148 (A431D/CD148wt cells, while they show no effects in A431D cells that lack CD148 or express a catalytically inactive form of CD148. The anti-proliferative effect of the TSP1 fragment in A431D/CD148wt cells was largely abolished by CD148 knockdown and antagonized by the 1st, but not the 2nd and 3rd, type 1 repeat fragment. Furthermore, the trimeric TSP1 fragments containing the 1st type repeat increased the catalytic activity of CD148 and reduced phospho-tyrosine contents of EGFR and ERK1/2, defined CD148 substrates. These effects were not observed in the TSP1 fragments that lack the 1st type 1 repeat. Last, we demonstrate that the trimeric TSP1 fragment containing the 1st type 1 repeat inhibits endothelial cell proliferation in culture and angiogenesis in vivo. These effects were largely abolished by CD148 knockdown or deficiency. Collectively, these findings indicate that the 1st type 1 repeat interacts with CD148, reducing growth factor signals and inhibiting epithelial or endothelial cell proliferation and angiogenesis.

  13. Busbar studies for the LHC interaction region quadrupoles

    CERN Document Server

    Bauer, P; Fehér, S; Kerby, J S; Lamm, M J; Orris, D; Sylvester, C D; Tompkins, J C; Zlobin, A V

    2001-01-01

    Fermilab (FNAL) and the Japanese high energy physics lab (KEK) are developing the superconducting quadrupole magnets for the interaction regions (IR) of the Large Hadron Collider (LHC). These magnets have a nominal field gradient of 215 T/m in a 70 mm bore and operate in superfluid helium at 1.9 K. The IR magnets are electrically interconnected with superconducting busbars, which need to be protected in the event of a quench. Experiments to determine the most suitable busbar design for the LHC IR magnets and the analysis of the data are presented. The main purpose of the study was to find a design that allows the inclusion of the superconducting busbars in the magnet quench protection scheme, thus avoiding additional quench protection circuitry. A proposed busbar design that was tested in these experiments consists of a superconducting cable, which is normally used for the inner layer of the Fermilab IR quadrupoles, soldered to similar Rutherford type cables as a stabilizer. A series of prototypes with varyin...

  14. Geoeffective Properties of Solar Transients and Stream Interaction Regions

    Science.gov (United States)

    Kilpua, E. K. J.; Balogh, A.; von Steiger, R.; Liu, Y. D.

    2017-09-01

    Interplanetary Coronal Mass Ejections (ICMEs), their possible shocks and sheaths, and co-rotating interaction regions (CIRs) are the primary large-scale heliospheric structures driving geospace disturbances at the Earth. CIRs are followed by a faster stream where Alfvénic fluctuations may drive prolonged high-latitude activity. In this paper we highlight that these structures have all different origins, solar wind conditions and as a consequence, different geomagnetic responses. We discuss general solar wind properties of sheaths, ICMEs (in particular those showing the flux rope signatures), CIRs and fast streams and how they affect their solar wind coupling efficiency and the resulting magnetospheric activity. We show that there are two different solar wind driving modes: (1) Sheath-like with turbulent magnetic fields, and large Alfvén Mach ( MA) numbers and dynamic pressure, and (2) flux rope-like with smoothly varying magnetic field direction, and lower MA numbers and dynamic pressure. We also summarize the key properties of interplanetary shocks for space weather and how they depend on solar cycle and the driver.

  15. Search for Asteroid-Asteroid Encounters

    Directory of Open Access Journals (Sweden)

    Luis A. Mammana

    2001-01-01

    Full Text Available Earlier studies about asteroids did not consider mutual interactions since they assume a negligible asteroid mass. In 1966 Hertz took into account for the first time the gravitational effects produced by an asteroid on another for mass determination. This gravitational action becomes relevant for enough effective encounters. The most efficient gravitational interaction is that produced in a large time interval and for small distances. For each particular caseful it is relevant to perform a care analysis in order to determinate the feasibility in the mass determination and improved orbital elements. In the present paper we performed a search of asteroid-asteroid encounters occurred in the twenty century for the first 3000 numbered asteroids . Of all encounters we have selected only those asteroid pairs in which one of the asteroids has a diameter larger than 200 km and the other one (the smaller an observational interval of at least ten years.

  16. Termite: Emulation Testbed for Encounter Networks

    Directory of Open Access Journals (Sweden)

    Rodrigo Bruno

    2015-08-01

    Full Text Available Cutting-edge mobile devices like smartphones and tablets are equipped with various infrastructureless wireless interfaces, such as WiFi Direct and Bluetooth. Such technologies allow for novel mobile applications that take advantage of casual encounters between co-located users. However, the need to mimic the behavior of real-world encounter networks makes testing and debugging of such applications hard tasks. We present Termite, an emulation testbed for encounter networks. Our system allows developers to run their applications on a virtual encounter network emulated by software. Developers can model arbitrary encounter networks and specify user interactions on the emulated virtual devices. To facilitate testing and debugging, developers can place breakpoints, inspect the runtime state of virtual nodes, and run experiments in a stepwise fashion. Termite defines its own Petri Net variant to model the dynamically changing topology and synthesize user interactions with virtual devices. The system is designed to efficiently multiplex an underlying emulation hosting infrastructure across multiple developers, and to support heterogeneous mobile platforms. Our current system implementation supports virtual Android devices communicating over WiFi Direct networks and runs on top of a local cloud infrastructure. We evaluated our system using emulator network traces, and found that Termite is expressive and performs well.

  17. Particle-In-Cell Simulations of the Solar Wind Interaction with Lunar Crustal Magnetic Anomalies: Magnetic Cusp Regions

    Science.gov (United States)

    Poppe, A. R.; Halekas, J. S.; Delory, G. T.; Farrell, W. M.

    2012-01-01

    As the solar wind is incident upon the lunar surface, it will occasionally encounter lunar crustal remanent magnetic fields. These magnetic fields are small-scale, highly non-dipolar, have strengths up to hundreds of nanotesla, and typically interact with the solar wind in a kinetic fashion. Simulations, theoretical analyses, and spacecraft observations have shown that crustal fields can reflect solar wind protons via a combination of magnetic and electrostatic reflection; however, analyses of surface properties have suggested that protons may still access the lunar surface in the cusp regions of crustal magnetic fields. In this first report from a planned series of studies, we use a 1 1/2-dimensional, electrostatic particle-in-cell code to model the self-consistent interaction between the solar wind, the cusp regions of lunar crustal remanent magnetic fields, and the lunar surface. We describe the self-consistent electrostatic environment within crustal cusp regions and discuss the implications of this work for the role that crustal fields may play regulating space weathering of the lunar surface via proton bombardment.

  18. Plankton motility patterns and encounter rates

    DEFF Research Database (Denmark)

    Visser, Andre; Kiørboe, Thomas

    2006-01-01

    measure of run length to reaction distance determines whether the underlying encounter is ballistic or diffusive. Since ballistic interactions are intrinsically more efficient than diffusive, we predict that organisms will display motility with long correlation run lengths compared to their reaction...... distances to their prey, but short compared to the reaction distances of their predators. We show motility data for planktonic organisms ranging from bacteria to copepods that support this prediction. We also present simple ballistic and diffusive motility models for estimating encounter rates, which lead...

  19. Disciplining the audiological encounter

    DEFF Research Database (Denmark)

    Hindhede, Anette Lykke

    2010-01-01

    This article addresses the social power variations in the context of audiological rehabilitation. The empirically based study examines the everyday interaction between professional medicine and the patient when hearing aids are being provided. By the use of video recordings an analysis is conduct...

  20. Disciplining the audiological encounter

    DEFF Research Database (Denmark)

    Lykke Hindhede, Anette

    2010-01-01

    This article addresses the social power variations in the context of audiological rehabilitation. The empirically based study examines the everyday interaction between professional medicine and the patient when hearing aids are being provided. By the use of video recordings an analysis is conduct...

  1. Estimating the Local Size and Coverage of Interaction Network Regions

    Science.gov (United States)

    Eagle, Michael; Barnes, Tiffany

    2015-01-01

    Interactive problem solving environments, such as intelligent tutoring systems and educational video games, produce large amounts of transactional data which make it a challenge for both researchers and educators to understand how students work within the environment. Researchers have modeled the student-tutor interactions using complex network…

  2. Universalist ethics in extraterrestrial encounter

    Science.gov (United States)

    Baum, Seth D.

    2010-02-01

    If humanity encounters an extraterrestrial civilization, or if two extraterrestrial civilizations encounter each other, then the outcome may depend not only on the civilizations' relative strength to destroy each other but also on what ethics are held by one or both civilizations. This paper explores outcomes of encounter scenarios in which one or both civilizations hold a universalist ethical framework. Several outcomes are possible in such scenarios, ranging from one civilization destroying the other to both civilizations racing to be the first to commit suicide. Thus, attention to the ethics of both humanity and extraterrestrials is warranted in human planning for such an encounter. Additionally, the possibility of such an encounter raises profound questions for contemporary human ethics, even if such an encounter never occurs.

  3. Centaur's ring system formation by close encounters

    Science.gov (United States)

    De Santana, Thamiris; Winter, Othon

    2016-10-01

    Rupture of small bodies due to close approach to a massive body is a frequent event in the Solar System. Some of these small bodies can just disintegrate completely or suffer a material loss.In this work we study the gravitational interaction between a giant planet and a small body in close encounters in order to simulate the formation of a planetary ring system around a centaur by the partial rupture of the small body.Considering the current Chariklo's body and a disk of particles around it, we simulated the system under close encounters with one of giant planets.Another motivation for the study is also the centaur Chiron, that is a candidate to have a ring system like Chariklo. The characteristics of the encounters are defined by the impact parameter and the velocity at infinity.The results are presented in terms of conditions that could lead to a rupture that could generate a ring like system.

  4. Determinants of customer satisfaction with service encounter

    Directory of Open Access Journals (Sweden)

    Ariana Nefat

    2008-12-01

    Full Text Available Service encounters are the focal point of a customer’s perception of a service in terms of its quality, value and customer satisfaction. The paper researches the influence of the components of a service encounter on customer satisfaction. Among several factors that determine customer satisfaction the quality of service, which is related to the characteristics of service, plays an important role. However, a direct insight into the reasons that make a service encounter satisfactory or unsatisfactory is provided by the critical incident technique, where causes of dis/satisfaction differ primarily depending on whether they derive from interpersonal contact or from contact with technology. The evidence of service, which includes people, process and the physical evidence, plays a critical role in a customer’s dis/satisfaction. The influence of these elements cannot be observed separately; it must be observed in their interaction during the delivery of service and their strongest effect is achieved during face-to-face service encounters that have the characteristics of a theatre metaphor. Even though a high level of satisfaction may be achieved after the recovery of a service, enterprises should aim to conduct excellent service encounters right from the start.

  5. Disciplining the audiological encounter

    DEFF Research Database (Denmark)

    Hindhede, Anette Lykke

    2010-01-01

    of the structural level of rehabilitation practice for hard-of-hearing working age people in two outpatient clinics in two different public hospitals in Denmark. It is shown that the hearing aid fitting consultations are conducted in a ritualised manner which makes it possible to control what kind of experiences......This article addresses the social power variations in the context of audiological rehabilitation. The empirically based study examines the everyday interaction between professional medicine and the patient when hearing aids are being provided. By the use of video recordings an analysis is conducted...

  6. Mass transfer between debris discs during close stellar encounters

    CERN Document Server

    Jilkova, Lucie; Hammer, Michael; Zwart, Simon Portegies

    2016-01-01

    We study mass transfers between debris discs during stellar encounters. We carried out numerical simulations of close flybys of two stars, one of which has a disc of planetesimals represented by test particles. We explored the parameter space of the encounters, varying the mass ratio of the two stars, their pericentre and eccentricity of the encounter, and its geometry. We find that particles are transferred to the other star from a restricted radial range in the disc and the limiting radii of this transfer region depend on the parameters of the encounter. We derive an approximate analytic description of the inner radius of the region. The efficiency of the mass transfer generally decreases with increasing encounter pericentre and increasing mass of the star initially possessing the disc. Depending on the parameters of the encounter, the transfer particles have a specific distributions in the space of orbital elements (semimajor axis, eccentricity, inclination, and argument of pericentre) around their new hos...

  7. Successful I.D. Encounters.

    Science.gov (United States)

    Poorman, Margaret J.

    Instructional Development (I.D.) encounters are dependent for success on such variables as power, politics, promotion, and organizational placement. I.D. consultants must be aware of power bases or orientation of other personnel and clients, e.g., these four "power personalities" which affect their efforts in managing I.D. encounters: the gate…

  8. Close encounters with DNA

    Science.gov (United States)

    Maffeo, C.; Yoo, J.; Comer, J.; Wells, D. B.; Luan, B.; Aksimentiev, A.

    2014-01-01

    Over the past ten years, the all-atom molecular dynamics method has grown in the scale of both systems and processes amenable to it and in its ability to make quantitative predictions about the behavior of experimental systems. The field of computational DNA research is no exception, witnessing a dramatic increase in the size of systems simulated with atomic resolution, the duration of individual simulations and the realism of the simulation outcomes. In this topical review, we describe the hallmark physical properties of DNA from the perspective of all-atom simulations. We demonstrate the amazing ability of such simulations to reveal the microscopic physical origins of experimentally observed phenomena and we review the frustrating limitations associated with imperfections of present atomic force fields and inadequate sampling. The review is focused on the following four physical properties of DNA: effective electric charge, response to an external mechanical force, interaction with other DNA molecules and behavior in an external electric field. PMID:25238560

  9. Rethinking social identity theory in international encounters:

    DEFF Research Database (Denmark)

    Lauring, Jakob

    2008-01-01

    In a globalized business environment, interaction across linguistic boundaries is becoming a normal part of everyday life. In these encounters language differences may affect the formation of social identities among organization members. While studies based on Social Identity Theory perceive...... the link between identity and language to be linear, this article takes a different approach. By drawing on anthropological theories on ethnic identity it is argued that the relation between language and social identity is negotiated in interaction. In the empirical analysis the article focuses...... on the encounter between expatriates and local employees of a Danish subsidiary in England. The findings show that identity making may be actualized by competition for resources and recognition. This can be done by investing certain objects such as the symbolic application of language with certain identifications...

  10. Accidental Beam Losses during Injection in the Interaction Region IRI

    CERN Document Server

    Bocian, D

    2004-01-01

    In this note some of the mechanisms that could lead to beam losses at the LHC are described. Events with beam losses in the ATLAS experimental cavern are discussed. Some possible accident scenarios during injection (Eb=450 GeV) are presented. The aim of this paper is to show the most probable regions of the beam impact in the ATLAS cavern due to the discussed accident scenarios.

  11. IMPROVEMENT OF INTERACTION BETWEEN CREDIT INSTITUTIONS AND ENTREPRENEURSHIP ORGANIZATIONS AT REGIONAL LEVEL

    Directory of Open Access Journals (Sweden)

    A. V. Russavskaya

    2011-01-01

    Full Text Available Interaction between credit and entrepreneurship organizations aimed at implementation of regional development programs should be improved according to the following main directions: better accessibility to financial resources; broader spectrum of consultancy, particularly business planning related services rendered to the business; more active cooperation with venture funds. Current regional crediting mechanisms are described for Kaluga Region as example.

  12. The Art of the Encounter

    Directory of Open Access Journals (Sweden)

    Éric Vautrin

    2013-03-01

    Full Text Available As the archives from the second half of Grotowski’s life were made available, this text focuses on the Polish master’s conceptions of theatre where he describes theatre as the art of the encounter. This paper simultaneously places this proposition in the context of questions of a specific time period, and reveals how this encounter is the anathema that will revert viewpoints both about the art of acting and the creation of theatrical relations. These researches on theatre as the art of the encounter continue today through the Open Program, one of the two groups of the Workcenter of Jerzy Grotowski and Thomas Richards, and, notably, their creations around American poet Allen Ginsberg, an author whose poetry intends, in a similar way, to encounter the other and the world.

  13. Nearshore regional behavior of lightning interaction with wind turbines

    Directory of Open Access Journals (Sweden)

    Gilbert A. Malinga

    2016-01-01

    Full Text Available The severity of lightning strikes on offshore wind turbines built along coastal and nearshore regions can pose safety concerns that are often overlooked. In this research study the behavior of electrical discharges for wind turbines that might be located in the nearshore regions along the East Coast of China and Sea of Japan were characterized using a physics-based model that accounted for a total of eleven different geometrical and lightning parameters. Utilizing the electrical potential field predicted using this model it was then possible to estimate the frequency of lightning strikes and the distribution of electrical loads utilizing established semi-empirical relationships and available data. The total number of annual lightning strikes on an offshore wind turbine was found to vary with hub elevation, extent of cloud cover, season and geographical location. The annual lightning strike rate on a wind turbine along the nearshore region on the Sea of Japan during the winter season was shown to be moderately larger compared to the lightning strike frequency on a turbine structure on the East Coast of China. Short duration electrical discharges, represented using marginal probability functions, were found to vary with season and geographical location, exhibiting trends consistent with the distribution of the electrical peak current. It was demonstrated that electrical discharges of moderately long duration typically occur in the winter months on the East Coast of China and the summer season along the Sea of Japan. In contrast, severe electrical discharges are typical of summer thunderstorms on the East Coast of China and winter frontal storm systems along the West Coast of Japan. The electrical charge and specific energy dissipated during lightning discharges on an offshore wind turbine was found to vary stochastically, with severe electrical discharges corresponding to large electrical currents of long duration.

  14. The Power of Citizens and Professionals in Welfare Encounters

    DEFF Research Database (Denmark)

    Mik-Meyer, Nanna

    relationships with welfare workers. However, other factors impact these interactions; factors which often pull in different directions. Welfare encounters are thus influenced by bureaucratic principles and market values as well. Consequently, this book engages with both Weberian (bureaucracy) and Foucauldian...

  15. Rethinking social identity theory in international encounters:

    DEFF Research Database (Denmark)

    Lauring, Jakob

    2008-01-01

    the link between identity and language to be linear, this article takes a different approach. By drawing on anthropological theories on ethnic identity it is argued that the relation between language and social identity is negotiated in interaction. In the empirical analysis the article focuses......In a globalized business environment, interaction across linguistic boundaries is becoming a normal part of everyday life. In these encounters language differences may affect the formation of social identities among organization members. While studies based on Social Identity Theory perceive....... It is finally argued that the processes by which identifications develop can cause both polarization and accommodation in the relation between groups and individuals.  ...

  16. Interactive Region Matching for 2D Animation Coloring Based on Feature's Variation

    Science.gov (United States)

    Garcia Trigo, Pablo; Johan, Henry; Imagire, Takashi; Nishita, Tomoyuki

    We propose an interactive method for assisting the coloring process of 2D hand-drawn animated cartoons. It segments input frames (each hand-drawn drawing of the cartoon) into regions (areas surrounded by closed lines. E.g. the head, the hands) extracts their features, and then matches the regions between frames, allowing the user to fix coloring mistakes interactively. Its main contribution consists in storing matched regions in lists called “chains” for tracking how the region features vary along the animation. Consequently, the matching rate is improved and the matching mistakes are reduced, thus reducing the total effort needed until having a correctly colored cartoon.

  17. The encounters that compose the research craft

    Directory of Open Access Journals (Sweden)

    Luciana Kind

    2016-07-01

    Full Text Available This paper discusses ethical and political dimensions of research, which is taken as social practice. To perform this research, with two teams in different regions of Brazil (Northeast and Southeast, building a truly collaborative work was an imperative task. The work process is problematized in a research involving women activists of two Brazilian social movements. The research process is discussed in four specific encouters. The first concerns the process of co-elaborating the project and the challenges of gathering distinct research interests. The second focuses on the daily challenges of staff in working with the theme of death, but also the synergy needed to work remotely. The third encounter discusses the relationship between researchers and participants, highlighting ethical and political dilemmas. The fourth and final encounter to be discussed the constraints posed by working with the theme of death, echoing among the participants and another researchers.

  18. Encountering social work through STS

    DEFF Research Database (Denmark)

    Birk, Rasmus

    Encountering social work through STS: Marginalization, materials and knowledge In this presentation, I attempt to produce an encounter between STS and social work. Concretely, I focus on the subset of social work called “local community work”, which in Denmark is used to intervene on marginalized...... and their inhabitants. Local community work derives from this assemblage of policy and knowledge as the “social” intervention commonly deployed. Based on an ethnographic field work, I examine how local community practices attempt to interpellate specific futures for individuals and their local environments. I do...... this by examining the materials and types of knowledge that participate in shaping local community work practices and encounters between local community workers and residents in marginalized housing areas. Through this analysis, I argue that social work research can benefit from orienting itself more concretely...

  19. Encounters along Micro-Level Borders: Silence and Metacommunicative Talk in Service Encounter Conversations between Finnish Employment Officials and Immigrants

    Directory of Open Access Journals (Sweden)

    Tarja Tanttu

    2014-12-01

    Full Text Available This article examines the interaction between Finnish employment officials and their immigrant clients in service encounter conversations. It employs the concepts of metacommunicative talk, silence, agency and asymmetric interaction situation. Such service encounters between native speakers of Finnish and immigrants going through the integration process and speaking Finnish as their second language constitute situations of institutional interaction, characterised by asymmetry. Asymmetry during the service encounter arises from the roles and power relations between the official and client, a familiarity with the routines associated with service encounters, and the use of Finnish as the language of conversation during the encounter. This article examines two authentic service encounters, recorded in a Finnish employment office. The encounters are analysed using discourse analysis, combining micro-level analysis of language use and macro-level analysis of the situation. Interviews with the employment officials and background information collected from the officials and clients via questionnaires are used in support of the qualita-tive analysis. Officials use different methods of interaction with their clients. In addition, the individual characteristics of officials and clients and their cultural differences in-fluence the construction of interaction during a service encounter. Finnish officials can sometimes handle service encounters with very little talk - sometimes with hardly any talk at all. However, metacommunicative talk can serve as a vehicle for reinforcing the client's agency and supporting the immigrant in learning the language and customs, as well as in establishing a foothold in the new community, and thereby promoting the integration process as a whole.

  20. Gender-specific spatial interactions on Dutch regional labour markets and the gender employment gap

    NARCIS (Netherlands)

    Noback, Inge; Broersma, Lourens; Van Dijk, Jouke

    2013-01-01

    Gender-specific spatial interactions on Dutch regional labour markets and the gender employment gap, Regional Studies. This paper analyses gender-specific employment rates and the gender employment gap in Dutch municipalities for 2002. The novelty of this analysis is that it takes into account the e

  1. Role of Electrostatic Interactions in Binding of Peptides and Intrinsically Disordered Proteins to Their Folded Targets: 2. The Model of Encounter Complex Involving the Double Mutant of the c-Crk N-SH3 Domain and Peptide Sos.

    Science.gov (United States)

    Yuwen, Tairan; Xue, Yi; Skrynnikov, Nikolai R

    2016-03-29

    In the first part of this work (paper 1, Xue, Y. et al. Biochemistry 2014 , 53 , 6473 ), we have studied the complex between the 10-residue peptide Sos and N-terminal SH3 domain from adaptor protein c-Crk. In the second part (this paper), we designed the double mutant of the c-Crk N-SH3 domain, W169F/Y186L, with the intention to eliminate the interactions responsible for tight peptide-protein binding, while retaining the interactions that create the initial electrostatic encounter complex. The resulting system was characterized experimentally by measuring the backbone and side-chain (15)N relaxation rates, as well as binding shifts and (1)H(N) temperature coefficients. In addition, it was also modeled via a series of ∼5 μs molecular dynamics (MD) simulations recorded in a large water box under an Amber ff99SB*-ILDN force field. Similar to paper 1, we have found that the strength of arginine-aspartate and arginine-glutamate salt bridges is overestimated in the original force field. To address this problem we have applied the empirical force-field correction described in paper 1. Specifically, the Lennard-Jones equilibrium distance for the nitrogen-oxygen pair across Arg-to-Asp/Glu salt bridges has been increased by 3%. This modification led to MD models in good agreement with the experimental data. The emerging picture is that of a fuzzy complex, where the peptide "dances" over the surface of the protein, making transient contacts via salt-bridge interactions. Every once in a while the peptide assumes a certain more stable binding pose, assisted by a number of adventitious polar and nonpolar contacts. On the other hand, occasionally Sos flies off the protein surface; it is then guided by electrostatic steering to quickly reconnect with the protein. The dynamic interaction between Sos and the double mutant of c-Crk N-SH3 gives rise to only small binding shifts. The peptide retains a high degree of conformational mobility, although it is appreciably slowed down due

  2. A Lakatosian Encounter with Probability

    Science.gov (United States)

    Chick, Helen

    2010-01-01

    There is much to be learned and pondered by reading "Proofs and Refutations" by Imre Lakatos (Lakatos, 1976). It highlights the importance of mathematical definitions, and how definitions evolve to capture the essence of the object they are defining. It also provides an exhilarating encounter with the ups and downs of the mathematical reasoning…

  3. Research on Interactive Relationship between Agricultural Insurance and Rural Financial Development in Central and Western Regions

    Institute of Scientific and Technical Information of China (English)

    2011-01-01

    By selecting the panel data from 2001 to 2008 in central and western regions,I adopt the methods of covariance analysis test,Hausman test,panel unit root test and co-integration test to conduct empirical research on the interactive relationship between agricultural insurance and rural financial development in central and western regions.The results show that there is a long-term balanced and interactive causal relationship between agricultural insurance and rural financial development in central and western regions.The agricultural insurance in western regions is the cause of rural financial development,while such relationship in central regions is not tenable.There is an interactive promotion relationship between agricultural insurance and rural financial development efficiency in central regions,while the relationship between agricultural insurance and rural financial development efficiency in western regions is mutually inhibitive,but the rural financial efficiency in western regions promotes the development of agricultural insurance.Then corresponding suggestions are put forward in order to give full play to the role of mutual promotion between agricultural insurance and rural financial development as follows:reinforce the support degree for policy finance in central and western regions;increase the inputs of rural financial institutions in serving agriculture,countryside and farmers;expand the types and coverage of policy agricultural insurance.

  4. Mapping of the regions involved in self-interaction of rice stripe virus P3 protein.

    Science.gov (United States)

    Zhao, S L; Hao, J H; Xue, Y N; Liang, C Y

    2016-03-01

    Rice stripe virus (RSV) protein P3 is a suppressor of RNA silencing in plants. P3 has been shown by biomolecular fluorescence complementation assay to self-interact in planta but the regions responsible for homotypic interaction have not been determined. Here we analyzed the domains for the self-interaction of P3 by using yeast two-hybrid, co-immunoprecipitation and fluorescence experiments. The results showed that P3 was also able to interact with itself in yeast and insect cells. The domain responsible for P3-P3 interaction was mapped to amino acids 15-30 at the N-terminal region of P3. Furthermore, subcellular localization suggested that the homo-oligomerization was the prerequisite for P3 to form larger protein aggregates in the nucleus of insect cell.

  5. SDO/AIA AND HINODE/EIS OBSERVATIONS OF INTERACTION BETWEEN AN EUV WAVE AND ACTIVE REGION LOOPS

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Liheng; Zhang, Jun; Li, Ting [Key Laboratory of Solar Activity, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Liu, Wei [W. W. Hansen Experimental Physics Laboratory, Stanford University, Stanford, CA 94305 (United States); Shen, Yuandeng, E-mail: yangliheng@bao.ac.cn, E-mail: zjun@bao.ac.cn, E-mail: liting@bao.ac.cn [Kwasan and Hida Observatories, Kyoto University, Kyoto 607-8471 (Japan)

    2013-09-20

    We present detailed analysis of an extreme-ultraviolet (EUV) wave and its interaction with active region (AR) loops observed by the Solar Dynamics Observatory/Atmospheric Imaging Assembly and the Hinode EUV Imaging Spectrometer (EIS). This wave was initiated from AR 11261 on 2011 August 4 and propagated at velocities of 430-910 km s{sup –1}. It was observed to traverse another AR and cross over a filament channel on its path. The EUV wave perturbed neighboring AR loops and excited a disturbance that propagated toward the footpoints of these loops. EIS observations of AR loops revealed that at the time of the wave transit, the original redshift increased by about 3 km s{sup –1}, while the original blueshift decreased slightly. After the wave transit, these changes were reversed. When the EUV wave arrived at the boundary of a polar coronal hole, two reflected waves were successively produced and part of them propagated above the solar limb. The first reflected wave above the solar limb encountered a large-scale loop system on its path, and a secondary wave rapidly emerged 144 Mm ahead of it at a higher speed. These findings can be explained in the framework of a fast-mode magnetosonic wave interpretation for EUV waves, in which observed EUV waves are generated by expanding coronal mass ejections.

  6. Social Media Interactions and Online Games - Building up New Human Relationships in Danube Region

    Directory of Open Access Journals (Sweden)

    Predrag K Nikolić

    2015-08-01

    Full Text Available In this paper we are trying to explore possibilities of using online environment, multiplayer gaming culture and social media networks to engage people in the Danube Region around social, multi-cultural and environment initiatives. The Danube Region online community could become a new cultural phenomena, technology mediated, built on human interactions, common interests and cultural heritage which open space for future humancentered social and infrastructural design initiatives. We believe that such social media environment could also be a research playground where people form Danube Region may express their needs and desires as well as to leave the trace of their behavior, significant for further Danube Region development.

  7. Monitoring inter-group encounters in wilderness

    Science.gov (United States)

    Alan E. Watson; Rich Cronn; Neal A. Christensen

    1998-01-01

    Many managers face the challenge of monitoring rates of visitor encounters in wilderness. This study (1) provides estimates of encounter rates through use of several monitoring methods, (2) determines the relationship between the various measures of encounter rates, and (3) determines the relationship between various indirect predictors of encounter rates and actual...

  8. Non-steady interaction of plasma with aircraft in its near wake region

    Institute of Scientific and Technical Information of China (English)

    Hu Tao-Ping; Luo Qing

    2007-01-01

    Non-steady interactions between plasmas and aircraft in its near wake region are investigated in detail. Under the non-static limit, a set of equations that describe these interactions are obtained. The results of the numerical simulation show that the cavitons of transverse plasmas are excited and density cavitons appear when the envelope of plasma becomes sufficiently intensive. This is very important for detecting the moving body that has a 'stealth' characteristic.

  9. The rate of stellar encounters along a migrating orbit of the Sun

    Science.gov (United States)

    Martínez-Barbosa, C. A.; Jílková, L.; Portegies Zwart, S.; Brown, A. G. A.

    2017-01-01

    The frequency of Galactic stellar encounters the Solar system experienced depends on the local density and velocity dispersion along the orbit of the Sun in the Milky Way galaxy. We aim at determining the effect of the radial migration of the solar orbit on the rate of stellar encounters. As a first step, we integrate the orbit of the Sun backwards in time in an analytical potential of the Milky Way. We use the present-day phase-space coordinates of the Sun, according to the measured uncertainties. The resulting orbits are inserted in an N-body simulation of the Galaxy, where the stellar velocity dispersion is calculated at each position along the orbit of the Sun. We compute the rate of Galactic stellar encounters by employing three different solar orbits - migrating from the inner disc, without any substantial migration and migrating from the outer disc. We find that the rate for encounters within 4 × 105 au from the Sun is about 21, 39 and 63 Myr-1, respectively. The stronger encounters establish the outer limit of the so-called parking zone, which is the region in the plane of the orbital eccentricities and semi-major axes where the planetesimals of the Solar system have been perturbed only by interactions with stars belonging to the Sun's birth cluster. We estimate the outer edge of the parking zone at semimajor axes of 250-1300 au (the outwards and inwards migrating orbits reaching the smallest and largest values, respectively), which is one order of magnitude smaller than the determination made by Portegies Zwart & Jílková. We further discuss the effect of stellar encounters on the stability of the hypothetical Planet 9.

  10. Social Media Interactions and Online Games - Building up New Human Relationships in Danube Region

    OpenAIRE

    Predrag K Nikolić

    2015-01-01

    In this paper we are trying to explore possibilities of using online environment, multiplayer gaming culture and social media networks to engage people in the Danube Region around social, multi-cultural and environment initiatives. The Danube Region online community could become a new cultural phenomena, technology mediated, built on human interactions, common interests and cultural heritage which open space for future humancentered social and infrastructural design initiatives...

  11. A comprehensive resource of interacting protein regions for refining human transcription factor networks.

    Directory of Open Access Journals (Sweden)

    Etsuko Miyamoto-Sato

    Full Text Available Large-scale data sets of protein-protein interactions (PPIs are a valuable resource for mapping and analysis of the topological and dynamic features of interactome networks. The currently available large-scale PPI data sets only contain information on interaction partners. The data presented in this study also include the sequences involved in the interactions (i.e., the interacting regions, IRs suggested to correspond to functional and structural domains. Here we present the first large-scale IR data set obtained using mRNA display for 50 human transcription factors (TFs, including 12 transcription-related proteins. The core data set (966 IRs; 943 PPIs displays a verification rate of 70%. Analysis of the IR data set revealed the existence of IRs that interact with multiple partners. Furthermore, these IRs were preferentially associated with intrinsic disorder. This finding supports the hypothesis that intrinsically disordered regions play a major role in the dynamics and diversity of TF networks through their ability to structurally adapt to and bind with multiple partners. Accordingly, this domain-based interaction resource represents an important step in refining protein interactions and networks at the domain level and in associating network analysis with biological structure and function.

  12. Interfaith dialogue as moral encounter

    DEFF Research Database (Denmark)

    Galal, Lise Paulsen

    The concept of interfaith dialogue has been introduced and developed by scholars of different religions. The aim has been to find solutions from within religion to handle and optimise encounters with religious ‘Others’. Furthermore, interfaith dialogue has increasingly become a tool to solve...... problems of integration and geopolitical conflicts. Thus the focus has changed from religion as the solution to an ontologically given differentiation, to religion being the problem that must be transgressed in order to meet on equal terms. In this paper, I discuss the setup of interfaith dialogue meetings...

  13. Special relativity a first encounter

    CERN Document Server

    Giulini, Domenico

    2005-01-01

    Special relativity provides the foundations of our knowledge of space and time. Without it, our understanding of the world, and its place in the universe, would be unthinkable. This book gives a concise, elementary, yet exceptionally modern, introduction to special relativity. It is a gentle yet serious 'first encounter', in that it conveys a true understanding rather than purely reports the basic facts. Only very elementary mathematical knowledge is needed to master it (basichigh-school maths), yet it will leave the reader with a sound understanding of the subject. Special Relativity: A First

  14. Identification of HIV-1 Vif regions required for CBF-β interaction and APOBEC3 suppression.

    Science.gov (United States)

    Wang, Hong; Liu, Bin; Liu, Xin; Li, Zhaolong; Yu, Xiao-Fang; Zhang, Wenyan

    2014-01-01

    Human immunodeficiency virus type 1 (HIV-1) Vif requires core binding factor β (CBF-β) to degrade the host APOBEC3 restriction factors. Although a minimum domain and certain amino acids of HIV-1 Vif, including hydrophobic residues at the N-terminal, have been identified as critical sites for binding with CBF-β, other regions that potentially mediate this interaction need to be further investigated. Here, we mapped two new regions of HIV-1 Vif that are required for interaction with CBF-β by generating a series of single-site or multiple-site Vif mutants and testing their effect on the suppression of APOBEC3G (A3G) and APOBEC3F (A3F). A number of the mutants, including G84A/SIEW86-89AAAA (84/86-89), E88A/W89A (88/89), G84A, W89A, L106S and I107S in the 84GxSIEW89 and L102ADQLI107 regions, affected Vif function by disrupting CBF-β binding. These Vif mutants also had altered interactions with CUL5, since CBF-β is known to facilitate the binding of Vif to CUL5. We further showed that this effect was not due to misfolding or conformational changes in Vif, as the mutants still maintained their interactions with other factors such as ElonginB, A3G and A3F. Notably, G84D and D104A had stronger effects on the Vif-CUL5 interaction than on the Vif-CBF-β interaction, indicating that they mainly influenced the CUL5 interaction and implying that the interaction of Vif with CUL5 contributes to the binding of Vif to CBF-β. These new binding interfaces with CBF-β in HIV-1 Vif provide novel targets for the development of HIV-1 inhibitors.

  15. Recent developments in modeling neutrino interactions in 1 GeV energy region

    CERN Document Server

    Sobczyk, Jan T

    2010-01-01

    Recent experimental and theoretical research in the area of neutrino interactions in the ~ 1 GeV region are reviewed including topics like: the problem of value of quasielastic axial mass, neutral current Pi0 production, coherent pion production. Many comments are devoted to status and current development of Monte Carlo events generators.

  16. Predicting of regional transpiration at elevated atmospheric CO2: influence of the PBL vegetation interaction.

    NARCIS (Netherlands)

    Jacobs, C.M.J.; Bruin, de H.A.R.

    1997-01-01

    A coupled planetary boundary layer (PBL)-vegetation model is used to study the influence of the PBL-vegetation interaction and the ambient CO2 concentration on surface resistance rs and regional transpiration E. Vegetation is described using the big-leaf model in which rs is modeled by means of a

  17. Predicting of regional transpiration at elevated atmospheric CO2: influence of the PBL vegetation interaction.

    NARCIS (Netherlands)

    Jacobs, C.M.J.; Bruin, de H.A.R.

    1997-01-01

    A coupled planetary boundary layer (PBL)-vegetation model is used to study the influence of the PBL-vegetation interaction and the ambient CO2 concentration on surface resistance rs and regional transpiration E. Vegetation is described using the big-leaf model in which rs is modeled by means of a co

  18. Overview of design development of FCC-hh Experimental Interaction Regions

    CERN Document Server

    Seryi, Andrei; Cruz Alaniz, Emilia; Van Riesen-Haupt, Leon; Benedikt, Michael; Besana, Maria Ilaria; Buffat, Xavier; Burkhardt, Helmut; Cerutti, Francesco; Langner, Andy Sven; Martin, Roman; Riegler, Werner; Schulte, Daniel; Tomas Garcia, Rogelio; Appleby, Robert Barrie; Rafique, Haroon; Barranco Garcia, Javier; Pieloni, Tatiana; Boscolo, Manuela; Collamati, Francesco; Nevay, Laurence James; Hofer, Michael

    2017-01-01

    The experimental interaction region (EIR) is one of the key areas that define the performance of the Future Circular Collider. In this overview we will describe the status and the evolution of the design of EIR of FCC-hh, focusing on design of the optics, energy deposition in EIR elements, beam-beam effects and machine detector interface issues.

  19. Application of interactive multiple goal programming techniques for analysis and planning of regional agricultural development.

    NARCIS (Netherlands)

    Wit, de C.T.; Keulen, van H.; Seligman, N.G.; Spharim, I.

    1988-01-01

    This paper describes a method of investigating development possibilities for a region under various constraints and demands. Use is made of an interactive multiple goal linear programming technique. The method is illustrated with an example from a semi-arid zone in the Mediterranean Basin. It is con

  20. Interaction-Region Design Options for a Linac-Ring LHeC

    Energy Technology Data Exchange (ETDEWEB)

    Zimmermann, Frank; /CERN; Bettoni, Simona; /CERN; Bruning, Oliver; /CERN; Holzer, Bernhard; /CERN; Russenschuck, Stephan; /CERN; Schulte, Daniel; /CERN; Tomas, Rogelio; /CERN; Aksakal, Husnu; /Nigde U.; Appleby, Robert; /Manchester U.; Chattopadhyay, Swapan; /Cockcroft Inst. Accel. Sci. Tech.; Korostelev, Maxim; /Cockcroft Inst. Accel. Sci. Tech.; Ciftci, Abbas; /Ankara U.; Ciftci, Rena; /Ankara U.; Zengin, Kahraman; /Ankara U.; Dainton, John; /Liverpool U.; Klein, Max; /Liverpool U.; Eroglu, Emre; /Uludag U.; Tapan, Ilhan; /Uludag U.; Kostka, Peter; /DESY; Litvinenko, Vladimir; /Brookhaven; Paoloni, Eugenio; /INFN, Pisa /INFN, Bologna /DESY /SLAC

    2012-06-21

    The interaction-region design for a linac-ring electron-proton collider based on the LHC ('LR-LHeC') poses numerous challenges related to collision scheme, synchrotron radiation, aperture, magnet technology, and optics. We report a first assessment and various options.

  1. Time evolution of initial states that extend beyond the potential interaction region in quantum decay

    Science.gov (United States)

    García-Calderón, Gastón; Villavicencio, Jorge; Hernández-Maldonado, Alberto; Romo, Roberto

    2016-08-01

    We investigate the decay of initial states that possess a tail that extends beyond the interaction potential region, for potentials of arbitrary shape that vanish exactly after a distance. This is the case for a relevant class of artificial quantum structures. We obtain that along the internal interaction region, the time evolution of the decaying wave function is formed by two terms. The first one refers to the proper decay of the internal portion of the initial state, whereas the second one, that arises from the external tail, yields a transient contribution that tunnels into the internal region, builds up to a value, and then decays. We obtain that depending on the parameters of the initial state, the nonexponential tail decaying contribution may be larger than the contribution of the proper nonexponential term. These results are illustrated by an exactly solvable model and the Heidelberg potential for decay of ultracold atoms and open the possibility to control initial states in artificial decaying systems.

  2. District nurses' views on quality of primary healthcare encounters.

    Science.gov (United States)

    Nygren Zotterman, Anna; Skär, Lisa; Olsson, Malin; Söderberg, Siv

    2015-09-01

    Good encounters are fundamental for good and professional nursing care, and can be described as treating patients with respect and protecting their integrity and autonomy. This study describes district nurses' views on quality of healthcare encounters in primary healthcare. A purposive sample of 27 district nurses participated in five focus group interviews. The focus groups interviews were digitally recorded and transcribed verbatim. The interview texts were analysed using a thematic content analysis. The analysis resulted in four themes, including being aware of the importance and difficulties during encounters, being the patient's advocate, being attentive to the unique person and being informed when a meeting turned out poorly. The results show that district nurses believed that encounters formed the basis of their work and it was vital for them to be aware of any difficulties. District nurses found that acting in a professional manner during encounters is the most significant factor, but this type of interaction was sometimes difficult because of stress and lack of time. The district nurses considered themselves to be the patients' advocate in the healthcare system; in addition, the acts of seeing, listening, believing and treating the patient seriously were important for providing good quality care. If a poor encounter occurred between the district nurse and the patient, the district nurses found that it was necessary to arrange a meeting to properly communicate what problems arose during the interaction. The district nurses highlighted that providing an apology and explanation could improve future encounters and establish a better nurse-patient relationship. In conclusion, this study shows the importance of confirming and respecting patients' dignity as the fundamental basis for a good quality encounter in primary healthcare.

  3. Mechanical Analysis of Fault Interaction in the Puente Hills Region, Los Angeles Basin, California

    Science.gov (United States)

    Griffith, W. A.; Cooke, M.

    2002-12-01

    A three-dimensional model of the Puente Hills thrust system (PHT) and the Whittier fault has been constructed using published cross sections, surface trace maps [Shaw (1999); Shaw and Suppe (1996); Wright (1991)] and products of the Southern California Earthquake Center. This study utilizes boundary element method models to validate the proposed fault geometry of the Puente Hills region via investigating fault interaction. The interaction between PHT and Whittier faults is evaluated within an elastic half-space under horizontal contraction and evidenced by slip rates on faults, strain energy density (SED), and Navier-Coulomb stress (NC) throughout the host rock. Modeled slip rates are compared to paleoseismic estimates to validate the proposed fault configuration while maps of SED and NC highlight regions of high strain in the host rock and likely faulting. Subsequently, the sensitivity of SED and NC distribution to changes in fault geometry illuminate the nature of fault interaction within this complex system of interacting faults. We explore interaction of faults within the PHT region using two sets of models. The first examines slip rates and SED and NC distribution within a local model of the PHT region while the second set incorporates the PHT faults within the context of the Los Angeles basin. Both sets explore the response of the fault system to systematic addition of faults. Adding faults within regions of high SED and NC does not influence slip on neighboring faults; however the addition of fault surfaces in regions of low/moderate SED and NC reduces slip along adjacent faults. The sensitivity of fault slip rates to direction of remote contraction in the Los Angeles Basin is examined with contraction directions of 036, 017, and 006.5 [Bawden (2001), Argus (1999), and Feigl (1993)]. Furthermore, variations on intersection geometry between the PHT and Whittier fault are explored. Portions of the PHT and Whittier faults show reasonable match to available

  4. The structure and institutions: a regional aspect of interaction in the economic system

    Directory of Open Access Journals (Sweden)

    Leonid Stepanovich Tarasevich

    2014-09-01

    Full Text Available In the article with the help of two-sector model of the economic system, the interaction of national and regional economy is investigated. This interaction is observed from the position of development of material structure and institutions. As the key structural parameter of an economy, the proportion between sector of excess resources and sector of scarce resources is taken. The situation when sector of excess resources prevails over sector of scarce resources forms structural conditions for the creation of the market institutions. If a sector of excess resources is smaller than a sector of scarce resources, the conditions for the emergence of institutions of government regulation are formed. Two cases are analyzed: the first one concerns the situation of a simple national economy consisting of 2 provisory regions. The second is the case of the national economy consisting of many regions. The authors show that material structure of a total combination of regions defines institutions of the market or state regulation for the national economy as a whole. The institutions formed at the level of the national economy, can support or resist the development of structure of the region. The conditions are observed under which united institutions of the national economy contradict a development of structure of the individual region.

  5. Regional septal hinge-point injury contributes to adverse biventricular interactions in pulmonary hypertension.

    Science.gov (United States)

    Nielsen, Eva Amalie; Okumura, Kenichi; Sun, Mei; Hjortdal, Vibeke E; Redington, Andrew N; Friedberg, Mark K

    2017-07-01

    Death and morbidity in pulmonary arterial hypertension (PAH) are often due to right ventricular (RV) failure and associated left ventricular (LV) dysfunction. We investigated regional myocardial remodeling and function as the basis for adverse ventricular-ventricular interactions in experimental chronic RV pressure overload. Two distinct animal models were studied: A rabbit model of increased RV pressure-load through progressive pulmonary artery banding A rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Regional myocardial function was assessed by speckle-tracking strain echocardiography and ventricular pressures measured by catheterization before termination. Regional RV and LV myocardium was analyzed for collagen content, apoptosis and pro-fibrotic signaling gene and protein expression. Although the RV developed more fibrosis than the LV; in both models the LV was substantially affected. In both ventricles, particularly the LV, fibrosis developed predominantly at the septal hinge-point regions in association with decreased regional and global circumferential strain, reduced global RV and LV function and up-regulation of regional transforming growth factor-β1 (TGFβ1) and apoptosis signaling. A group of PAH rats who received the TGFβ blocker SB431542 showed improved RV function and reduced regional hinge-point myocardial fibrosis. RV pressure-loading and PAH lead to biventricular TGFβ1 signaling, fibrosis and apoptosis, predominantly at the septal hinge-point regions, in association with regional myocardial dysfunction. This suggests that altered geometry and wall stress lead to adverse RV-LV interactions through the septal hinge-points to induce LV fibrosis and dysfunction. © 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society.

  6. Lateral and medial ventral occipitotemporal regions interact during the recognition of images revealed from noise

    Directory of Open Access Journals (Sweden)

    Barbara eNordhjem

    2016-01-01

    Full Text Available Several studies suggest different functional roles for the medial and the lateral ventral sections in object recognition. Texture and surface information is processed in medial regions, while shape information is processed in lateral sections. This begs the question whether and how these functionally specialized sections interact with each other and with early visual cortex to facilitate object recognition. In the current research, we set out to answer this question. In an fMRI study, thirteen subjects viewed and recognized images of objects and animals that were gradually revealed from noise while their brains were being scanned. We applied dynamic causal modeling (DCM – a method to characterize network interactions – to determine the modulatory effect of object recognition on a network comprising the primary visual cortex (V1, the lingual gyrus (LG in medial ventral cortex and the lateral occipital cortex (LO. We found that object recognition modulated the bilateral connectivity between LG and LO. Moreover, the feed-forward connectivity from V1 to LG and LO was modulated, while there was no evidence for feedback from these regions to V1 during object recognition. In particular, the interaction between medial and lateral areas supports a framework in which visual recognition of objects is achieved by networked regions that integrate information on image statistics, scene content and shape – rather than by a single categorically specialized region – within the ventral visual cortex.

  7. Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction.

    Directory of Open Access Journals (Sweden)

    Erin J Heckler

    Full Text Available Soluble guanylyl cyclase (sGC is a heterodimeric nitric oxide (NO receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system. NO binds to heme in the β subunit and stimulates the catalytic conversion of GTP to cGMP several hundred fold. Several endogenous factors have been identified that modulate sGC function in vitro and in vivo. In previous work, we determined that protein disulfide isomerase (PDI interacts with sGC in a redox-dependent manner in vitro and that PDI inhibited NO-stimulated activity in cells. To our knowledge, this was the first report of a physical interaction between sGC and a thiol-redox protein. To characterize this interaction between sGC and PDI, we first identified peptide linkages between sGC and PDI, using a lysine cross-linking reagent and recently developed mass spectrometry analysis. Together with Flag-immunoprecipitation using sGC domain deletions, wild-type (WT and mutated PDI, regions of sGC involved in this interaction were identified. The observed data were further explored with computational modeling to gain insight into the interaction mechanism between sGC and oxidized PDI. Our results indicate that PDI interacts preferentially with the catalytic domain of sGC, thus providing a mechanism for PDI inhibition of sGC. A model in which PDI interacts with either the α or the β catalytic domain is proposed.

  8. Network Interaction of Universities in Higher Education System of Ural Macro-Region

    Directory of Open Access Journals (Sweden)

    Garold Efimovich Zborovsky

    2017-06-01

    Full Text Available The subject-matter of the analysis are the characteristics and forms of cooperation between universities of Ural Federal District on the basis of their typology. The purpose of the article is to substantiate the necessity and possibility of network interaction between universities of the macro-region. We prove the importance and potential effectiveness of universities network interaction in the terms of socio-economic uncertainty of the development of Ural Federal District and its higher education. Networking interaction and multilateral cooperation are considered as a new type of inter-universities relations, which can be activated and intensified by strengthening the relations of universities with stakeholders. The authors examine certain concrete forms and formats of network interaction and cooperation between universities and discuss selected cases of new type of relations. In it, they see the real and potential innovation of higher school nonlinear development processes. The statements of the article allow to confirm the hypothesis about the reality of strengthening the network interaction in macro-region. It can transform higher education in the driver of socio-economic development of Ural Federal District; ensure the competitiveness of higher education of the macro-region in the Russian and global educational space; enhance its role in the society; become one of the most significant elements of nonlinear models of higher education development in the country. The authors’ research is based on the interdisciplinary methodology including the potential of theoretical sociology, sociology of higher education, economic sociology, management theory, regional economics. The results of the study can form the basis for the improvement of the Ural Federal District’s educational policy.

  9. Module discovery by exhaustive search for densely connected, co-expressed regions in biomolecular interaction networks.

    Science.gov (United States)

    Colak, Recep; Moser, Flavia; Chu, Jeffrey Shih-Chieh; Schönhuth, Alexander; Chen, Nansheng; Ester, Martin

    2010-10-25

    Computational prediction of functionally related groups of genes (functional modules) from large-scale data is an important issue in computational biology. Gene expression experiments and interaction networks are well studied large-scale data sources, available for many not yet exhaustively annotated organisms. It has been well established, when analyzing these two data sources jointly, modules are often reflected by highly interconnected (dense) regions in the interaction networks whose participating genes are co-expressed. However, the tractability of the problem had remained unclear and methods by which to exhaustively search for such constellations had not been presented. We provide an algorithmic framework, referred to as Densely Connected Biclustering (DECOB), by which the aforementioned search problem becomes tractable. To benchmark the predictive power inherent to the approach, we computed all co-expressed, dense regions in physical protein and genetic interaction networks from human and yeast. An automatized filtering procedure reduces our output which results in smaller collections of modules, comparable to state-of-the-art approaches. Our results performed favorably in a fair benchmarking competition which adheres to standard criteria. We demonstrate the usefulness of an exhaustive module search, by using the unreduced output to more quickly perform GO term related function prediction tasks. We point out the advantages of our exhaustive output by predicting functional relationships using two examples. We demonstrate that the computation of all densely connected and co-expressed regions in interaction networks is an approach to module discovery of considerable value. Beyond confirming the well settled hypothesis that such co-expressed, densely connected interaction network regions reflect functional modules, we open up novel computational ways to comprehensively analyze the modular organization of an organism based on prevalent and largely available large

  10. Module discovery by exhaustive search for densely connected, co-expressed regions in biomolecular interaction networks.

    Directory of Open Access Journals (Sweden)

    Recep Colak

    Full Text Available BACKGROUND: Computational prediction of functionally related groups of genes (functional modules from large-scale data is an important issue in computational biology. Gene expression experiments and interaction networks are well studied large-scale data sources, available for many not yet exhaustively annotated organisms. It has been well established, when analyzing these two data sources jointly, modules are often reflected by highly interconnected (dense regions in the interaction networks whose participating genes are co-expressed. However, the tractability of the problem had remained unclear and methods by which to exhaustively search for such constellations had not been presented. METHODOLOGY/PRINCIPAL FINDINGS: We provide an algorithmic framework, referred to as Densely Connected Biclustering (DECOB, by which the aforementioned search problem becomes tractable. To benchmark the predictive power inherent to the approach, we computed all co-expressed, dense regions in physical protein and genetic interaction networks from human and yeast. An automatized filtering procedure reduces our output which results in smaller collections of modules, comparable to state-of-the-art approaches. Our results performed favorably in a fair benchmarking competition which adheres to standard criteria. We demonstrate the usefulness of an exhaustive module search, by using the unreduced output to more quickly perform GO term related function prediction tasks. We point out the advantages of our exhaustive output by predicting functional relationships using two examples. CONCLUSION/SIGNIFICANCE: We demonstrate that the computation of all densely connected and co-expressed regions in interaction networks is an approach to module discovery of considerable value. Beyond confirming the well settled hypothesis that such co-expressed, densely connected interaction network regions reflect functional modules, we open up novel computational ways to comprehensively analyze

  11. Interaction Between Two Distinct Mesoscale Circulations During Summer in the Coastal Region of Eastern USA

    Science.gov (United States)

    Sims, Aaron P.; Raman, Sethu

    2016-07-01

    The interaction of two phenomena, a sea-breeze front and a thermally-driven local circulation, is investigated during the summer season. The sea-breeze circulation in the coastal Carolinas (USA) can be quite strong and the sea-breeze front often propagates well inland. The Sandhills, an area of sandy soils, is oriented roughly parallel to the coast and is located approximately 180 km inland. Differential heating is a strong driving force for convective development in this coastal region and the Sandhills front develops from the thermally-driven circulation caused by the differential heating of differing soil types. The sea-breeze and the Sandhills circulations have been previously studied independently, however, the interaction of these two phenomena is not well known. A combination of remote sensing, in situ observations, and numerical simulations is used to examine the interaction of these two fronts with remote sensing and in situ observations revealing the differential heating that occurs along the Sandhills region. Radar reflectivity is used to identify the two frontal features that converge and result in enhanced convection. A modelling simulation reveals the vertical structure of the frontal features, their propagation, and interaction, highlighting the interaction of the two fronts that results in enhanced convection between the Sandhills and the coast. Over the Sandhills region, differential heating triggers convective storms. Radar reflectivity and numerical simulation indicate the outflows from these convective storms to produce a shallow Sandhills front that in turn propagates toward the coast. As the two opposing fronts, the Sandhills front and the sea-breeze front, converge and interact, intense convection occurs resulting in additional storms.

  12. Stellar Encounters with Massive Star-Disk Systems

    CERN Document Server

    Moeckel, N; Moeckel, Nickolas; Bally, John

    2006-01-01

    The dense, clustered environment in which massive stars form can lead to interactions with neighboring stars. It has been hypothesized that collisions and mergers may contribute to the growth of the most massive stars. In this paper we extend the study of star-disk interactions to explore encounters between a massive protostar and a less massive cluster sibling using the publicly available SPH code GADGET-2. Collisions do not occur in the parameter space studied, but the end state of many encounters is an eccentric binary with a semi-major axis ~ 100 AU. Disk material is sometimes captured by the impactor. Most encounters result in disruption and destruction of the initial disk, and periodic torquing of the remnant disk. We consider the effect of the changing orientation of the disk on an accretion driven jet, and the evolution of the systems in the presence of on-going accretion from the parent core.

  13. Regional factors interact with educational and income tax levels to influence food intake in France.

    Science.gov (United States)

    Wyndels, K; Dallongeville, J; Simon, C; Bongard, V; Wagner, A; Ruidavets, J-B; Arveiler, D; Ferrières, J; Amouyel, P; Dauchet, L

    2011-09-01

    The goal of the present study was to assess whether geographic factors affect the relationship between socioeconomic indicators and adherence to the French National Nutritional Health Programme (Programme National Nutrition Santé (PNNS)) guidelines. The MONA LISA-NUT study (2005-2007) is a cross-sectional survey of a representative sample from northern, northeastern and southwestern France. Educational level and household income tax were recorded by trained interviewers. Food intake was assessed with a 3-day food diary in 3188 subjects aged from 35-64 years. Adherence to the PNNS guidelines was assessed with a validated score (the French score of indicators of the PNNS objective (FSIPO)). Multivariate analyses were adjusted for gender, age, marital status, body mass index, energy intake and medically prescribed diets. The FSIPO score was higher in southwestern France than in the two other regions (P<0.0001). The FSIPO score was correlated with the educational level in northern and northeastern France (P<0.0001) but not in southwestern France (region-education interaction: P<0.001). This interaction was accounted for by fruit and vegetable (P<0.0001), calcium (P=0.03), saturated fatty acid (P<0.0001), and fibre (P=0.0001) components of the FSIPO score. In contrast, the income tax level and the FSIPO score were positively correlated (P<0.0001) to a similar extent in all three regions (region × income tax interaction: P=0.09). The relationship between educational level and adherence to the national nutritional health guidelines differs from one region of France to another, suggesting that nutrition education programmes should perhaps be adapted on a regional basis. In contrast, guideline adherence is correlated with income tax level independently of geographical factors, suggesting that financial constraints on food choices are uniform across France.

  14. Machine detector interface studies: Layout and synchrotron radiation estimate in the future circular collider interaction region

    CERN Document Server

    Boscolo, Manuela; Sullivan, Michael Kenneth

    2017-01-01

    The interaction region layout for the e$^+$e$^−$ future circular collider FCC-ee is presented together with a preliminary estimate of synchrotron radiation that affects this region. We describe in this paper the main guidelines of this design and the estimate of synchrotron radiation coming from the last bending magnets and from the final focus quadrupoles, with the software tools developed for this purpose. The design follows the asymmetric optics layout as far as incoming bend radiation is concerned with the maximum foreseen beam energy of 175 GeV and we present a feasible initial layout with an indication of tolerable synchrotron radiation.

  15. Colliding beam physics at Fermilab: interaction regions, beam storage, antiproton cooling, production, and colliding

    Energy Technology Data Exchange (ETDEWEB)

    Walker, J.K. (ed.)

    1977-01-01

    The purpose of the colliding beams experment department at Fermilab was to bring about collisions of the stored beams in the energy doubler/saver and main ring, and construct experimental areas with appropriate detectors. To explore the feasibility of using the main ring as a storage device, several studies were carried out to investigate beam growth, loss, and the backgrounds in detectors at possible intersection regions. This range of developments constituted the major topics at the 1977 Summer Study reported here. Emphasis in part one is on interaction regions, beam storage, antiproton cooling, production, and colliding. 40 papers from this part are included in the data base. (GHT)

  16. Machine detector interface studies: Layout and synchrotron radiation estimate in the future circular collider interaction region

    Directory of Open Access Journals (Sweden)

    Manuela Boscolo

    2017-01-01

    Full Text Available The interaction region layout for the e^{+}e^{-} future circular collider FCC-ee is presented together with a preliminary estimate of synchrotron radiation that affects this region. We describe in this paper the main guidelines of this design and the estimate of synchrotron radiation coming from the last bending magnets and from the final focus quadrupoles, with the software tools developed for this purpose. The design follows the asymmetric optics layout as far as incoming bend radiation is concerned with the maximum foreseen beam energy of 175 GeV and we present a feasible initial layout with an indication of tolerable synchrotron radiation.

  17. Machine detector interface studies: Layout and synchrotron radiation estimate in the future circular collider interaction region

    Science.gov (United States)

    Boscolo, Manuela; Burkhardt, Helmut; Sullivan, Michael

    2017-01-01

    The interaction region layout for the e+e- future circular collider FCC-ee is presented together with a preliminary estimate of synchrotron radiation that affects this region. We describe in this paper the main guidelines of this design and the estimate of synchrotron radiation coming from the last bending magnets and from the final focus quadrupoles, with the software tools developed for this purpose. The design follows the asymmetric optics layout as far as incoming bend radiation is concerned with the maximum foreseen beam energy of 175 GeV and we present a feasible initial layout with an indication of tolerable synchrotron radiation.

  18. PROGRESS ON THE INTERACTION REGION DESIGN AND DETECTOR INTEGRATION AT JLAB'S MEIC

    Energy Technology Data Exchange (ETDEWEB)

    Morozov, Vasiliy; Brindza, Paul; Camsonne, Alexandre; Derbenev, Yaroslav; Ent, Rolf; Gaskell, David; Lin, Fanglei; Nadel-Turonski, Pawel; Ungaro, Maurizio; Zhang, Yuhong; Hyde, Charles; Park, Kijun; Sullivan, Michael; Zhao, Zhiwen

    2014-07-01

    One of the unique features of JLab's Medium-energy Electron-Ion Collider (MEIC) is a full-acceptance detector with a dedicated, small-angle, high-resolution detection system, capable of covering a wide range of momenta (and charge-to-mass ratios) with respect to the original ion beam to enable access to new physics. We present an interaction region design developed with close integration of the detection and beam dynamical aspects. The dynamical aspect of the design rests on a symmetry-based concept for compensation of non-linear effects. The optics and geometry have been optimized to accommodate the detection requirements and to ensure the interaction region's modularity for ease of integration into the collider ring lattices. As a result, the design offers an excellent detector performance combined with the necessary provisions for non-linear dynamical optimization.

  19. An improved method for pancreas segmentation using SLIC and interactive region merging

    Science.gov (United States)

    Zhang, Liyuan; Yang, Huamin; Shi, Weili; Miao, Yu; Li, Qingliang; He, Fei; He, Wei; Li, Yanfang; Zhang, Huimao; Mori, Kensaku; Jiang, Zhengang

    2017-03-01

    Considering the weak edges in pancreas segmentation, this paper proposes a new solution which integrates more features of CT images by combining SLIC superpixels and interactive region merging. In the proposed method, Mahalanobis distance is first utilized in SLIC method to generate better superpixel images. By extracting five texture features and one gray feature, the similarity measure between two superpixels becomes more reliable in interactive region merging. Furthermore, object edge blocks are accurately addressed by re-segmentation merging process. Applying the proposed method to four cases of abdominal CT images, we segment pancreatic tissues to verify the feasibility and effectiveness. The experimental results show that the proposed method can make segmentation accuracy increase to 92% on average. This study will boost the application process of pancreas segmentation for computer-aided diagnosis system.

  20. On Magnetic Activity Band Overlap, Interaction, and the Formation of Complex Solar Active Regions

    CERN Document Server

    McIntosh, Scott W

    2014-01-01

    Recent work has revealed an phenomenological picture of the how the $\\sim$11-year sunspot cycle of Sun arises. The production and destruction of sunspots is a consequence of the latitudinal-temporal overlap and interaction of the toroidal magnetic flux systems that belong to the 22-year magnetic activity cycle and are rooted deep in the Sun's convective interior. We present a conceptually simple extension of this work, presenting a hypothesis on how complex active regions can form as a direct consequence of the intra- and extra-hemispheric interaction taking place in the solar interior. Furthermore, during specific portions of the sunspot cycle we anticipate that those complex active regions may be particular susceptible to profoundly catastrophic breakdown---producing flares and coronal mass ejections of most severe magnitude.

  1. A New Interaction Region Design for the Super-B Factory

    Energy Technology Data Exchange (ETDEWEB)

    Sullivan, Michael; /SLAC; Bertsche, Kirk; /SLAC; Bettoni, Simona; /CERN; Paoloni, Eugenio; /INFN, Pisa; Raimondi, Pantaleo; /INFN, Rome; Vobly, Pavel; /Novosibirsk, IYF

    2012-07-06

    A final focus magnet design that uses super-ferric magnets is introduced for the SuperB interaction region. The baseline design has air-core super-conducting quadrupoles. This idea instead uses super-conducting wire in an iron yoke. The iron is in the shape of a Panofsky quadrupole and this allows two quadrupoles to be side-by-side with no intervening iron as long as the gradients of the two quads are equal. This feature allows us to move in as close as possible to the collision point and minimize the beta functions in the interaction region. The superferric design has advantages as well as drawbacks and we will discuss these in the paper.

  2. A New Interaction Region Design for the Super-B Factory

    CERN Document Server

    Sullivan, Michael; Bettoni, Simona; Paoloni, Eugenio; Raimondi, Pantaleo; Vobly, Pavel

    2010-01-01

    A final focus magnet design that uses super-ferric magnets is introduced for the SuperB interaction region. The baseline design has air-core super-conducting quadrupoles. This idea instead uses super-conducting wire in an iron yoke. The iron is in the shape of a Panofsky quadrupole and this allows two quadrupoles to be sideby- side with no intervening iron as long as the gradients of the two quads are equal. This feature allows us to move in as close as possible to the collision point and minimize the beta functions in the interaction region. The superferric design has advantages as well as drawbacks and we will discuss these in the pape

  3. Multiple Codes, Multiple Impressions: An Analysis of Doctor-Client Encounters in Nigeria

    Science.gov (United States)

    Odebunmi, Akin

    2013-01-01

    Existing studies on doctor-client interactions have largely focused on monolingual encounters and the interactional effects and functions of the languages used in the communication between doctors and their clients. They have neither, to a large extent, examined the several codes employed in single encounters and their pragmatic roles nor given…

  4. Multiple Codes, Multiple Impressions: An Analysis of Doctor-Client Encounters in Nigeria

    Science.gov (United States)

    Odebunmi, Akin

    2013-01-01

    Existing studies on doctor-client interactions have largely focused on monolingual encounters and the interactional effects and functions of the languages used in the communication between doctors and their clients. They have neither, to a large extent, examined the several codes employed in single encounters and their pragmatic roles nor given…

  5. Atomic Spectrum in Ramsey Separated Oscillating Fields with Three Interaction Regions

    Institute of Scientific and Technical Information of China (English)

    CHEN Jingbiao; WANG Fengzhi; YANG Donghai; WANG YiQiu

    2001-01-01

    Comparing with the situation of Ramsey separated oscillating fields used in Cesium atomic beam frequency standard, the transition probability spectrum of two-level atoms in the Ramsey separated oscillating fields with three interaction regions has been derived under the condition of near resonance. The new characteristic of atomic spectrum with excessive microwave power was analyzed in detail. Meantime, the predicted new characteristic of atomic spectrum was confirmed by numerical method in this paper.

  6. Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate.

    Science.gov (United States)

    Esakova, Olga; Perederina, Anna; Berezin, Igor; Krasilnikov, Andrey S

    2013-08-01

    Ribonuclease (RNase) MRP is a ubiquitous and essential site-specific eukaryotic endoribonuclease involved in the metabolism of a wide range of RNA molecules. RNase MRP is a ribonucleoprotein with a large catalytic RNA moiety that is closely related to the RNA component of RNase P, and multiple proteins, most of which are shared with RNase P. Here, we report the results of an ultraviolet-cross-linking analysis of interactions between a photoreactive RNase MRP substrate and the Saccharomyces cerevisiae RNase MRP holoenzyme. The results show that the substrate interacts with phylogenetically conserved RNA elements universally found in all enzymes of the RNase P/MRP family, as well as with a phylogenetically conserved RNA region that is unique to RNase MRP, and demonstrate that four RNase MRP protein components, all shared with RNase P, interact with the substrate. Implications for the structural organization of RNase MRP and the roles of its components are discussed.

  7. Alien encounter a scientific novel

    CERN Document Server

    Schulze-Makuch, Dirk

    2014-01-01

    It has been nearly 100 years since the Apollo moon landings, when Jack and Vladimir, two astronauts on a mission to Venus, discover a mysterious void related to indigenous life on the planet. Subsequently more voids are detected on Earth, Mars, Titan, and, quite ominously, inside a planetoid emerging from the Kuiper belt. Jack is sent to investigate the voids in the Solar System and intercept the planetoid - which, as becomes increasingly clear, is inhabited by alien life forms. Jack and his crew will have little time to understand their alien biochemistry, abilities, behavior patterns, resilience, and technology, but also how these life forms relate to the voids. Humankind's first encounter with these exotic life forms couldn't be more fateful, becoming a race against time to save life on Earth and to reveal the true nature of the voids, which seem to be intrinsically related to life and the universe itself. In this novel, the author combines many topics related to state-of-the-art research in the field of...

  8. Encounters with Translations of Happiness

    Directory of Open Access Journals (Sweden)

    T. Titchkosky

    2013-11-01

    Full Text Available This special issue edited by Katie Aubrecht demonstrates that a focus on translations of happiness makes us attend to the interpretive process animating social relations. There are many registers of translation that individuals, communities, and the state make use of as they grapple with relations to happiness. Among the vast array of historical registers that aim to make happiness comprehensible or compelling, medicine and politics are two of the most noteworthy. Moving from one register to another, such as from institutional versions of happiness as a medically regulated matter, to its appearance in situations of war, trauma, illness, local community or state, between these differing registers, we come to re-encounter happiness in many important ways as this special issue demonstrates. This issue thus invites its readers to question modernity’s progressive interest in and use of happiness as a way to narrate and assemble our essential inter-relatedness.

  9. Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo.

    Science.gov (United States)

    Shabani, Driton; Tahiri, Zejdush; Bara, Petrit; Hudhra, Klejda; Malaj, Ledian; Jucja, Besnik; Bozalia, Adnan; Burazeri, Genc

    2014-08-01

    Our aim was to assess the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the adult population of transitional Kosovo. A cross-sectional study was conducted including a representative sample of 1921 patients aged ≥18 years (mean age: 57.8±11.2 years; 50.3% women; overall response: 96%) from the regional hospital of Gjilan, Kosovo, during 2011-2013. Potential drug-drug-interactions were assessed and clinical data as well as demographic and socioeconomic information were collected. Binary logistic regression was used to assess the correlates of drug-drug interactions. Upon multivariable adjustment for all the demographic and socioeconomic factors as well as the clinical characteristics, drug-drug interactions were positively and significantly related to older age (OR=2.1, 95%CI=1.3-2.8), a lower educational attainment (OR=1.4, 95%CI=1.1-1.9), a longer hospitalization period (OR=2.7, 95%CI=2.1-3.6), presence of three groups of diseases [infectious diseases (OR=1.7, 95%CI=1.3-2.4), cardiovascular diseases (OR=1.8, 95%CI=1.4-2.6), respiratory diseases (OR=1.6, 95%CI=1.2-2.5)], presence of comorbid conditions (OR=3.2, 95%CI=2.3-4.4) and an intake of at least four drugs (OR=5.9, 95%CI=4.6-7.1). Our study provides important evidence on the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the hospitalized patients in the regional hospital of Gjilan, Kosovo. Findings from our study should raise the awareness of decision-makers and policy makers about the prevalence and determinants of drug-drug interactions in the adult population of post-war Kosovo.

  10. INTERRUPTED STELLAR ENCOUNTERS IN STAR CLUSTERS

    Energy Technology Data Exchange (ETDEWEB)

    Geller, Aaron M. [Center for Interdisciplinary Exploration and Research in Astrophysics (CIERA) and Department of Physics and Astronomy, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208 (United States); Leigh, Nathan W. C., E-mail: a-geller@northwestern.edu, E-mail: nleigh@amnh.org [Department of Astrophysics, American Museum of Natural History, Central Park West and 79th Street, New York, NY 10024 (United States)

    2015-07-20

    Strong encounters between single stars and binaries play a pivotal role in the evolution of star clusters. Such encounters can also dramatically modify the orbital parameters of binaries, exchange partners in and out of binaries, and are a primary contributor to the rate of physical stellar collisions in star clusters. Often, these encounters are studied under the approximation that they happen quickly enough and within a small enough volume to be considered isolated from the rest of the cluster. In this paper, we study the validity of this assumption through the analysis of a large grid of single–binary and binary–binary scattering experiments. For each encounter we evaluate the encounter duration, and compare this with the expected time until another single or binary star will join the encounter. We find that for lower-mass clusters, similar to typical open clusters in our Galaxy, the percent of encounters that will be “interrupted” by an interloping star or binary may be 20%–40% (or higher) in the core, though for typical globular clusters we expect ≲1% of encounters to be interrupted. Thus, the assumption that strong encounters occur in relative isolation breaks down for certain clusters. Instead, many strong encounters develop into more complex “mini-clusters,” which must be accounted for in studying, for example, the internal dynamics of star clusters, and the physical stellar collision rate.

  11. Necessity of the stalk region for immunoglobulin E interaction with CD23.

    Science.gov (United States)

    Chen, Bing-Hung; Ma, Check; Caven, Timothy H; Chan-Li, Yee; Beavil, Andrew; Beavil, Rebecca; Gould, Hannah; Conrad, Daniel H

    2002-11-01

    Previously, a soluble mouse CD23 chimera, composed of an N-terminal trimeric isoleucine zipper motif (lz) followed by the entire extracellular region (amino acids 48-331) of CD23 (lz-CD2348-331), was prepared and exhibited strong binding to rodent immunoglobulin E (IgE). In the current study, we report the construction of a similar human chimeric protein (lz-huCD2345-321), as well as a series of murine chimeric lz-CD23 mutants with incremental portions of stalk deleted, to further investigate the role of the stalk region in mediating the CD23-IgE interaction. All chimeric proteins were designed such that the predicted heptad structure of the stalk was retained. IgE binding, as determined by the capacity to inhibit 125I-IgE from binding to FcepsilonRI-bearing RBL-2H3 cells, and by surface plasmon-resonance analysis using an IgE-coated sensor chip, was unchanged from the original lz chimera and the binding parameters were similar to those of cell-surface CD23. The minimal murine chimera that retained IgE-binding activity was lz-CD23139-331, which still contains 35 amino acids of the stalk region. When the lz motif was linked to CD23 amino acid 157 (or higher), significant IgE-binding capacity was lost. With human lz-CD23, as with mouse, deletion of the stalk greatly reduced IgE-binding ability. In summary, the data support the concept that at least a portion of the stalk region of CD23 plays a crucial role in maintaining high-affinity/avidity interaction with IgE. The lz-CD23 constructs represent a possible alternative for both blocking the IgE/FcepsilonRI interaction and inhibiting IgE production by B lymphocytes.

  12. DO COROTATING INTERACTION REGION ASSOCIATED SHOCKS SURVIVE WHEN THEY PROPAGATE INTO THE HELIOSHEATH?

    Energy Technology Data Exchange (ETDEWEB)

    Provornikova, E.; Opher, M. [Astronomy Department, Boston University, Boston, MA 02215 (United States); Izmodenov, V. [Department of Air Mechanics and Gas Dynamics, Faculty of Mechanics and Mathematics, Lomonosov Moscow State University, Moscow 119991 (Russian Federation); Toth, G., E-mail: eprovorn@bu.edu, E-mail: mopher@bu.edu, E-mail: izmod@iki.rssi.ru, E-mail: gtoth@umich.edu [Center for Space Environment Modeling, University of Michigan, Ann Arbor, MI 48109 (United States)

    2012-09-10

    During the solar minimum at the distance of 42-52 AU from the Sun, Voyager 2 observed recurrent sharp, shock-like increases in the solar wind speed that look very much like forward shocks (Lazarus et al.). The shocks were produced by corotating interaction regions (CIRs) that originated near the Sun. After the termination shock (TS) crossing in 2007, Voyager 2 entered the heliosheath and has been observing the plasma emanated during the recent solar minima. Measurements show high variable flow, but there were no shocks detected in the heliosheath. When CIR-driven shocks propagate to the outer heliosphere, their structure changes due to collision and merging processes of CIRs. In this Letter, we explore an effect of the merging of CIRs on the structure of CIR-associated shocks. We use a three-dimensional MHD model to study the outward propagation of the shocks with characteristics similar to those observed by Voyager 2 at {approx}45 AU (Lazarus et al. 1999). We show that due to merging of CIRs (1) reverse shocks disappear, (2) forward shocks become weaker due to interaction with rarefaction regions from preceding CIRs, and (3) forward shocks significantly weaken in the heliosheath. Merged CIRs produce compression regions in the heliosheath with small fluctuations of plasma parameters. Amplitudes of the fluctuations diminish as they propagate deeper in the sheath. We conclude that interaction of shocks and rarefaction regions could be one of the explanations, why shocks produced by CIRs are not observed in the heliosheath by Voyager 2 while they were frequently observed upstream the TS.

  13. Interharmonic modulation products as a means to quantify nonlinear D-region interactions

    Science.gov (United States)

    Moore, Robert

    Experimental observations performed during dual beam ionospheric HF heating experiments at the High frequency Active Auroral Research Program (HAARP) HF transmitter in Gakona, Alaska are used to quantify the relative importance of specific nonlinear interactions that occur within the D region ionosphere. During these experiments, HAARP broadcast two amplitude modulated HF beams whose center frequencies were separated by less than 20 kHz. One beam was sinusoidally modulated at 500 Hz while the second beam was sinusoidally modulated using a 1-7 kHz linear frequency-time chirp. ELF/VLF observations performed at two different locations (3 and 98 km from HAARP) provide clear evidence of strong interactions between all field components of the two HF beams in the form of low and high order interharmonic modulation products. From a theoretical standpoint, the observed interharmonic modulation products could be produced by several different nonlinearities. The two primary nonlinearities take the form of wave-medium interactions (i.e., cross modulation), wherein the ionospheric conductivity modulation produced by one signal crosses onto the other signal via collision frequency modification, and wave-wave interactions, wherein the conduction current associated with one wave mixes with the electric field of the other wave to produce electron temperature oscillations. We are able to separate and quantify these two different nonlinearities, and we conclude that the wave-wave interactions dominate the wave-medium interactions by a factor of two. These results are of great importance for the modeling of transioinospheric radio wave propagation, in that both the wave-wave and the wave-medium interactions could be responsible for a significant amount of anomalous absorption.

  14. A close encounter of the massive kind

    Science.gov (United States)

    Maíz Apellániz, J.; Sana, H.; Barbá, R. H.; Le Bouquin, J.-B.; Gamen, R. C.

    2017-01-01

    We have used (i) Hubble Space Telescope Advanced Camera for Surveys imaging and Space Telescope Imaging Spectrograph spectroscopy, (ii) ground-based Precision Integrated-Optics Near-infrared Imaging ExpeRiment/Very Large Telescope long-baseline interferometry, and (iii) ground-based spectroscopy from different instruments to study the orbit of the extreme multiple system HD 93 129 Aa,Ab, which is composed of (at least) two very massive stars in a long-period orbit with e > 0.92, which will pass through periastron in 2017/2018. In several ways, the system is an η Car precursor. Around the time of periastron passage, the two very strong winds will collide and generate an outburst of non-thermal hard X-ray emission without precedent in an O+O binary since astronomers have been able to observe above Earth's atmosphere. A coordinated multiwavelength monitoring in the next two years will enable a breakthrough understanding of the wind interactions in such extreme close encounters. Furthermore, we have found evidence that HD 93 129 Aa may be a binary system itself. In that case, we could witness a three-body interaction which may yield a runaway star or a stellar collision close to or shortly after the periastron passage. Either of those outcomes would be unprecedented, as they are predicted to be low-frequency events in the Milky Way.

  15. A close encounter of the massive kind

    CERN Document Server

    Apellániz, J Maíz; Barbá, R H; Bouquin, J -B Le; Gamen, R C

    2016-01-01

    We have used (a) HST ACS imaging and STIS spectroscopy, (b) ground-based PIONIER/VLT long-baseline interferometry, and (c) ground-based spectroscopy from different instruments to study the orbit of the extreme multiple system HD 93 129 Aa,Ab, which is composed of (at least) two very massive stars in a long-period orbit with e>0.92 that will pass through periastron in 2017/2018. In several ways, the system is an eta Car precursor. Around the time of periastron passage the two very strong winds will collide and generate an outburst of non-thermal hard X-ray emission without precedent in an O+O binary since astronomers have been able to observe above Earth's atmosphere. A coordinated multiwavelength monitoring in the next two years will enable a breakthrough understanding of the wind interactions in such extreme close encounters. Furthermore, we have found evidence that HD 93 129 Aa may be a binary system itself. In that case, we could witness a three-body interaction that may yield a runaway star or a stellar c...

  16. A functional interaction approach to the definition of meso regions: The case of the Czech Republic

    Directory of Open Access Journals (Sweden)

    Erlebach Martin

    2016-06-01

    Full Text Available The definition of functional meso regions for the territory of the Czech Republic is articulated in this article. Functional regions reflect horizontal interactions in space and are presented as a useful tool for various types of geographical analyses, and also for spatial planning, economic policy designs, etc. This paper attempts to add to the discussion on the need to delineate areal units at different hierarchical levels, and to understand the functional flows and spatial behaviours of the population in a given space. Three agglomerative methods are applied in the paper (the CURDS regionalisation algorithm, Intramax, and cluster analysis, and they have not been used previously in Czech geography for the delineation of functional meso regions. Existing functional regions at the micro-level, based on daily travel-to-work flows from the 2001 census, have served as the building blocks. The analyses have produced five regional systems at the meso level, based on daily labour commuting movements of the population. Basic statistics and a characterisation of these systems are provided in this paper.

  17. Performance of upstream interaction region detectors for the FIRST experiment at GSI

    CERN Document Server

    Abou-Haidar, Z; Alvarez, M A G; Anelli, M; Aumann, T; Battistoni, G; Bocci, A; Bohlen, T T; Boudard, A; Brunetti, A; Carpinelli, M; Cirrone, G A P; Cortes-Giraldo, M A; Cuttone, G; De Napoli, M; Durante, M; Fernandez-Garcia, J P; Finck, C; Gallardo, M I; Golosio, B; Iarocci, E; Iazzi, F; Ickert, G; Introzzi, R; Juliani, D; Krimmer, J; Kurz, N; Labalme, M; Leifels, Y; Le Fevre, A; Leray, S; Marchetto, F; Monaco, V; Morone, M C; Oliva, P; Paoloni, A; Patera, V; Piersanti, L; Pleskac, R; Quesada, J M; Randazzo, N; Romano, F; Rossi, D; Rosso, V; Rousseau, M; Sacchi, R; Sala, P; Sarti, A; Schuy, C; Sciubba, A; Sfienti, C; Simon, H; Sipala, V; Spiriti, E; Stuttge, L; Tropea, S; Younis, H

    2012-01-01

    The FIRST (Fragmentation of Ions Relevant for Space and Therapy) experiment at GSI has been designed to study carbon fragmentation, measuring (12)C double differential cross sections (- (2)I /- - E) for different beam energies between 100 and 1000 MeV/u. The experimental setup integrates newly designed detectors in the, so called, Interaction Region around the graphite target. The Interaction Region upstream detectors are a 250 mum thick scintillator and a drift chamber optimized for a precise measurement of the ions interaction time and position on the target. In this article we review the design of the upstream detectors along with the preliminary results of the data taking performed on August 2011 with 400 MeV/u fully stripped carbon ion beam at GSI. Detectors performances will be reviewed and compared to those obtained during preliminary tests, performed with 500 MeV electrons (at the BTF facility in the INFN Frascati Laboratories) and 80 MeV/u protons and carbon ions (at the INFN LNS Laboratories in Cata...

  18. Simulation of Crab Waist Collisions in DAΦNE with KLOE-2 Interaction Region

    Energy Technology Data Exchange (ETDEWEB)

    Zobov, M. [Frascati; Drago, A. [Frascati; Gallo, A. [Frascati; Milardi, C. [Frascati; Shatilov, D. [Novosibirsk, IYF; Valishev, A. [Fermilab

    2015-06-24

    After the successful completion of the SIDDHARTA experiment run with crab waist collisions, the electron-positron collider DAΦNE has started routine operations for the KLOE-2 detector. The new interaction region also exploits the crab waist collision scheme, but features certain complications including the experimental detector solenoid, compensating anti-solenoids, and tilted quadrupole magnets. We have performed simulations of the beam-beam collisions in the collider taking into account the real DAΦNE nonlinear lattice. In particular, we have evaluated the effect of crab waist sextupoles and beam-beam interactions on the DAΦNE dynamical aperture and energy acceptance, and estimated the luminosity that can be potentially achieved with and without crab waist sextupoles in the present working conditions. A numerical analysis has been performed in order to propose possible steps for further luminosity increase in DAΦNE such as a better working point choice, crab sextupole strength optimization, correction of the phase advance between the sextupoles and the interaction region. The proposed change of the e⁻ ring working point was implemented and resulted in a significant performance increase.

  19. Simulation of Crab Waist Collisions In DA$\\Phi$NE With KLOE-2 Interaction Region

    Energy Technology Data Exchange (ETDEWEB)

    Zobov, M. [National Inst. of Nuclear Physics (INFN), Frascati (Italy). National Lab. of Frascati (INFN-LNF); Drago, A. [National Inst. of Nuclear Physics (INFN), Frascati (Italy). National Lab. of Frascati (INFN-LNF); Gallo, A. [National Inst. of Nuclear Physics (INFN), Frascati (Italy). National Lab. of Frascati (INFN-LNF); Milardi, C. [National Inst. of Nuclear Physics (INFN), Frascati (Italy). National Lab. of Frascati (INFN-LNF); Shatilov, D. [Russian Academy of Sciences (RAS), Novosibirsk (Russian Federation). Budker Inst. of Nuclear Physics (BINP); Valishev, A. [Fermi National Accelerator Lab. (FNAL), Batavia, IL (United States)

    2015-06-24

    After the successful completion of the SIDDHARTA experiment run with crab waist collisions, the electron-positron collider DAΦNE has started routine operations for the KLOE-2 detector. The new interaction region also exploits the crab waist collision scheme, but features certain complications including the experimental detector solenoid, compensating anti-solenoids, and tilted quadrupole magnets. We have performed simulations of the beam-beam collisions in the collider taking into account the real DAΦNE nonlinear lattice. In particular, we have evaluated the effect of crab waist sextupoles and beam-beam interactions on the DAΦNE dynamical aperture and energy acceptance, and estimated the luminosity that can be potentially achieved with and without crab waist sextupoles in the present working conditions. A numerical analysis has been performed in order to propose possible steps for further luminosity increase in DAΦNE such as a better working point choice, crab sextupole strength optimization, correction of the phase advance between the sextupoles and the interaction region. The proposed change of the e- ring working point was implemented and resulted in a significant performance increase.

  20. THE MAIN TRENDS OF INTERACTION BETWEEN THE ADMINISTRATION OF ROSPOTREBNADZOR IN THE LENINGRAD REGION AND THE GOVERNMENT OF LENINGRAD REGION IN THE FIELD OF POPULATION RADIATION PROTECTION

    Directory of Open Access Journals (Sweden)

    S. A. Gorbanev

    2008-01-01

    Full Text Available The article gives the main interaction trends of the Administration of Rospotrebnadzor in the Leningrad Region and the Government of Leningrad Region regarding issues of regional radiation protection. It reports on comprehensive measures devoted to the limitation of the population exposure from natural irradiation sources, monitoring of territories which suffered from Chernobyl NPP accident and monitoring of the environmental impact of unauthorized dumps and solid municipal waste sites in the Leningrad Region. It presents the basic issues of medical exposure limitation in the Leningrad Region and measures for their solving.

  1. Understanding the collective encounter patterns in an empirical urban contact network

    CERN Document Server

    Sun, Lijun; Lee, Der-Horng; Huang, Xianfeng

    2013-01-01

    Despite the well-documented social links in human networks such as personal relationships, cooperation and communication, physical encounters are displaying their significance in diverse scales, from knowledge spillover to epidemic spreading. However, our knowledge of the mechanism driving our encounters is still limited owing to the lack of dataset describing both individual behaviours and collective interactions in large-scale. With the help of smart card data, here we uncover such mechanisms by constructing a time-resolved in-vehicle encounter networks on public buses in a city. In population level, we found physical encounters display reproducible temporal patterns, indicating the repeated encounters are regular and identical. In individual level, we found that collective regularities have overtaken the bounded nature of distinct encounter and one's encounter capability is highly rooted in his/her daily behaviour regularity, explaining the emergence of "familiar strangers" in daily life. More strikingly, ...

  2. Interactions between trophic levels in upwelling and non-upwelling regions during summer monsoon

    Science.gov (United States)

    Malik, A.; Fernandes, C. E. G.; Gonsalves, M.-J. B. D.; Subina, N. S.; Mamatha, S. S.; Krishna, K.; Varik, S.; Kumari, R.; Gauns, M.; Cejoice, R. P.; Pandey, S. S.; Jineesh, V. K.; Kamaleson, A. S.; Vijayan, V.; Mukherjee, I.; Subramanyan, S.; Nair, S.; Ingole, B.; LokaBharathi, P. A.

    2015-01-01

    Coastal upwelling is a regular phenomenon occurring along the southwest coast of India during summer monsoon (May-September). We hypothesize that there could be a shift in environmental parameters along with changes in the network of interactions between bacteria, phytoplankton, and zooplankton in upwelling and non-upwelling regions. During cruise # 267 on FORV Sagar Sampada, water samples were analysed for environmental and biological parameters from two transects, one upwelling region off Trivandrum (TVM) (8°26‧N, 76°20‧E-8°30‧N, 76°50‧E), and the other non-upwelling region off Calicut (CLT) (11°11‧N, 75°30‧E-11°14‧N,74°54‧E), about 230 nmi to the north. Meteorological, hydrological, and nutrient profiles confirmed upwelling off TVM. Bacteria, phytoplankton and zooplankton significantly responded. Primary and bacterial productivity enhanced together with increase in the percentage of viable bacteria (TVC). Pearson's correlation analysis pointed out the differences in bacterial interactions with other trophic levels at both transects. TVC played a prominent role in trophic interactions off TVM by depending on phytoplankton for substrate (r = 0.754). This contrasted with CLT where total counts (TC) played an important role. However, most interrelationships were less pronounced. Principal component analysis (PCA) confirmed the correlation analysis and further showed that the factor loadings of the biotic and abiotic parameters differed in strength and direction in the two regions. More importantly, the processes of mineralization by bacteria and uptake by phytoplankton are obviously more coupled off TVM as evidenced by the clustering of the related parameters in the PCA biplot. Canonical correspondence analysis also complements these findings and demonstrated that the abiotic factors influenced phytoplankton and bacteria similarly at TVM but differently at CLT. The impact on the trophic interrelationships is evident by the close association

  3. Effects of encounter in a population of spatial prisoner's dilemma players.

    Science.gov (United States)

    Zhang, Chunyan; Zhang, Jianlei; Xie, Guangming; Wang, Long

    2011-11-01

    We study the evolution of cooperation in spatial prisoner's dilemma games, whereby each player extends its interaction scope by trying to interact with a certain number of encounters randomly chosen from its non-neighbors, in addition to its permanently linked nearest neighbors. Furthermore, the non-neighbors treat the initiative interactions in two scenarios: definitely accepting that from the cooperators, whereas guardedly interacting with defectors with an acceptance probability which may take arbitrary value in [0,1]. Importantly, our results reveal that the proposed encounter mechanism is a potent extrinsic factor that is able to boost cooperation when appropriately adjusting the values of the encounter number and acceptance probability, though rational players would always defect in one-shot encounters, regardless of the action from the counterparts. We hope our studies may help understand that the proposed encounter mechanism is also an important ingredient of a flourishing cooperative society.

  4. Determinants of customer satisfaction with service encounter

    OpenAIRE

    Ariana Nefat; Nika Paus

    2008-01-01

    Service encounters are the focal point of a customer’s perception of a service in terms of its quality, value and customer satisfaction. The paper researches the influence of the components of a service encounter on customer satisfaction. Among several factors that determine customer satisfaction the quality of service, which is related to the characteristics of service, plays an important role. However, a direct insight into the reasons that make a service encounter satisfactory or unsatisfa...

  5. Interactions between temperature and drought in global and regional crop yield variability during 1961-2014.

    Science.gov (United States)

    Matiu, Michael; Ankerst, Donna P; Menzel, Annette

    2017-01-01

    Inter-annual crop yield variation is driven in large parts by climate variability, wherein the climate components of temperature and precipitation often play the biggest role. Nonlinear effects of temperature on yield as well as interactions among the climate variables have to be considered. Links between climate and crop yield variability have been previously studied, both globally and at regional scales, but typically with additive models with no interactions, or when interactions were included, with implications not fully explained. In this study yearly country level yields of maize, rice, soybeans, and wheat of the top producing countries were combined with growing season temperature and SPEI (standardized precipitation evapotranspiration index) to determine interaction and intensification effects of climate variability on crop yield variability during 1961-2014. For maize, soybeans, and wheat, heat and dryness significantly reduced yields globally, while global effects for rice were not significant. But because of interactions, heat was more damaging in dry than in normal conditions for maize and wheat, and temperature effects were not significant in wet conditions for maize, soybeans, and wheat. Country yield responses to climate variability naturally differed between the top producing countries, but an accurate description of interaction effects at the country scale required sub-national data (shown only for the USA). Climate intensification, that is consecutive dry or warm years, reduced yields additionally in some cases, however, this might be linked to spillover effects of multiple growing seasons. Consequently, the effect of temperature on yields might be underestimated in dry conditions: While there were no significant global effects of temperature for maize and soybeans yields for average SPEI, the combined effects of high temperatures and drought significantly decreased yields of maize, soybeans, and wheat by 11.6, 12.4, and 9.2%, respectively.

  6. Choosing a language in international office service encounters

    DEFF Research Database (Denmark)

    Hazel, Spencer

    Choosing a language in international office service encounters – from multilingual miscellany to medium-of-interaction in a matter of seconds Spencer Hazel Roskilde University, Denmark In higher education settings characterized by increasing transnational student and staff mobility, members...... Preisler (eds.) Language alternation, language choice and language encounter in international education. Dordrecht: Springer Preisler, Bent, Ida Klitgård, and Anne H. Fabricius. (2011). Language and learning in the international university: from English uniformity to diversity and hybridity. Bristol...... are required to navigate dynamically fluctuating participation frameworks and their contingent language scenarios. Although some interactional settings have institutionally implemented rules or norms relating to which language is the designated medium-of-interaction, this is not the case across all settings...

  7. Gravitational waves from stellar encounters

    CERN Document Server

    Capozziello, Salvatore

    2008-01-01

    The emission of gravitational waves from a system of massive objects interacting on elliptical, hyperbolic and parabolic orbits is studied in the quadrupole approximation. Analytical expressions are then derived for the gravitational wave luminosity, the total energy output and gravitational radiation amplitude. A crude estimate of the expected number of events towards peculiar targets (i.e. globular clusters) is also given. In particular, the rate of events per year is obtained for the dense stellar cluster at the Galactic Center.

  8. A cartography of maternity, subjectivity and art-encounters

    Directory of Open Access Journals (Sweden)

    Paula McCloskey

    2010-01-01

    Full Text Available This text introduces a research project in motion. The area is maternity, subjectivity and art encounters. The text gives a sense of this research, presenting both the process of thinking within and about the work, showing it to be a living inquiry. The research itself is located in my disrupted maternal-self and an encounter with the oeuvre of Louise Bourgeois; an encounter that had a transformative impact on me by creating a space to contemplate my experiences and beyond to explore maternity, subjectivity and art encounters. This text gives a sense of the origins of this work before starting to consider how the research developed to transcend the bounds of my experience. It shows how the concepts of 'maternity, experience, subjectivity, encounter' and 'art 'have been put to work in interaction with objects (and makes the links from this activity to the work of Mieke Bal. The objects are separated into both 'existing' and 'generated objects', including written texts (writing my story or reflective writing, and existent texts/literature, art objects, my note/sketch books, interview transcripts and filmed interviews. The concepts and objects are used to develop a 'dialogue' – with each other, the reader, the viewer and me, in order to create the space or the conditions where thinking and ideas about these objects and concepts can emerge. This text considers how the research uses different practices and tools to facilitate the interaction between concepts and objects, plus continuous analysis and reflexivity, with the aim of producing new ideas and understandings of maternity, subjectivity and art encounters.

  9. Identifying familiar strangers in human encounter networks

    Science.gov (United States)

    Liang, Di; Li, Xiang; Zhang, Yi-Qing

    2016-10-01

    Familiar strangers, pairs of individuals who encounter repeatedly but never know each other, have been discovered for four decades yet lack an effective method to identify. Here we propose a novel method called familiar stranger classifier (FSC) to identify familiar strangers from three empirical datasets, and classify human relationships into four types, i.e., familiar stranger (FS), in-role (IR), friend (F) and stranger (S). The analyses of the human encounter networks show that the average number of FS one may encounter is finite but larger than the Dunbar Number, and their encounters are structurally more stable and denser than those of S, indicating the encounters of FS are not limited by the social capacity, and more robust than the random scenario. Moreover, the temporal statistics of encounters between FS over the whole time span show strong periodicity, which are diverse from the bursts of encounters within one day, suggesting the significance of longitudinal patterns of human encounters. The proposed method to identify FS in this paper provides a valid framework to understand human encounter patterns and analyse complex human social behaviors.

  10. Shell-model calculations in 132Sn and 208Pb regions with low-momentum interactions

    CERN Document Server

    Gargano, A; Covello, A; Itaco, N

    2009-01-01

    We discuss shell-model calculations based on the use of low-momentum interactions derived from the free-space nucleon-nucleon potential. A main feature of this approach is the construction of a smooth potential, V-low-k, defined within a given momentum cutoff. As a practical application of the theoretical framework, we present some selected results of our current study of nuclei around doubly magic 132Sn and 208Pb which have been obtained starting from the CD-Bonn potential. Focusing attention on the similarity between the spectroscopy of these two regions, we show that it emerges quite naturally from our effective interactions without use of any adjustable parameter.

  11. submitter ELECTRON CLOUD AND COLLECTIVE EFFECTS IN THE INTERACTION REGION OF FCC-ee

    CERN Document Server

    Belli, E; Rumolo, G

    2016-01-01

    The FCC-ee is an e⁺e⁻ circular collider designed to accommodate four different experiments in a beam energy range from 91 to 350 GeV and is a part of the Future Circular Collider (FCC) project at CERN. One of the most critical aspects of this new very challenging machine regards the collective effects which can produce instabilities, thus limiting the accelerator operation and reducing its performance. The following studies are focused on the Interaction Region of the machine. This talk will present preliminary simulation results of the power loss due to the wake fields generated by the electromagnetic interaction of the beam with the vacuum chamber. A preliminary estimation of the electron cloud build-up is also reported, whose effects have been recognized as one of the main limitations for the Large Hadron Collider at CERN.

  12. Excitation of the Orbital Inclination of Iapetus during Planetary Encounters

    CERN Document Server

    Nesvorny, David; Deienno, Rogerio; Walsh, Kevin J

    2014-01-01

    Saturn's moon Iapetus has an orbit in a transition region where the Laplace surface is bending from the equator to the orbital plane of Saturn. The orbital inclination of Iapetus to the local Laplace plane is ~8 deg, which is unexpected, because the inclination should be ~0 if Iapetus formed from a circumplanetary disk on the Laplace surface. It thus appears that some process has pumped up Iapetus's inclination while leaving its eccentricity near zero (e=0.03 at present). Here we examined the possibility that Iapetus's inclination was excited during the early solar system instability when encounters between Saturn and ice giants occurred. We found that the dynamical effects of planetary encounters on Iapetus's orbit sensitively depend on the distance of the few closest encounters. In four out of ten instability cases studied here, the orbital perturbations were too large to be plausible. In one case, Iapetus's orbit was practically unneffected. In the remaining five cases, the perturbations of Iapetus's incli...

  13. Mutational analysis of Trypanosoma brucei RNA editing ligase reveals regions critical for interaction with KREPA2.

    Directory of Open Access Journals (Sweden)

    Vaibhav Mehta

    Full Text Available The Trypanosoma brucei parasite causes the vector-borne disease African sleeping sickness. Mitochondrial mRNAs of T. brucei undergo posttranscriptional RNA editing to make mature, functional mRNAs. The final step of this process is catalyzed by the essential ligase, T. brucei RNA Editing Ligase 1 (TbREL1 and the closely related T. brucei RNA Editing Ligase 2 (TbREL2. While other ligases such as T7 DNA ligase have both a catalytic and an oligonucleotide/oligosaccharide-binding (OB-fold domain, T. brucei RNA editing ligases contain only the catalytic domain. The OB-fold domain, which is required for interaction with the substrate RNA, is provided in trans by KREPA2 (for TbREL1 and KREPA1 (for TbREL2. KREPA2 enhancement of TbREL1 ligase activity is presumed to occur via an OB-fold-mediated increase in substrate specificity and catalysis. We characterized the interaction between TbREL1 and KREPA2 in vitro using full-length, truncated, and point-mutated ligases. As previously shown, our data indicate strong, specific stimulation of TbREL1 catalytic activity by KREPA2. We narrowed the region of contact to the final 59 C-terminal residues of TbREL1. Specifically, the TbREL1 C-terminal KWKE (441-444 sequence appear to coordinate the KREPA2-mediated enhancement of TbREL1 activities. N-terminal residues F206, T264 and Y275 are crucial for the overall activity of TbREL1, particularly for F206, a mutation of this residue also disrupts KREPA2 interaction. Thus, we have identified the critical TbREL1 regions and amino acids that mediate the KREPA2 interaction.

  14. Interaction Region for a 100 TeV Proton-Proton Collider

    CERN Document Server

    Martin, R; Dalena, B

    2015-01-01

    As part of its post-LHC high energy physics program, CERN is conducting a study for a new proton-proton collider, FCC-hh, running at center-of-mass energies of up to 100 TeV, pushing the energy frontier of fundamental physics to a new limit. At a circumference of 80-100 km, this machine is planned to use the same tunnel as FCC-ee, a proposed 90-350 GeV high luminosity electron-positron collider. This paper presents the design progress and technical challenges for the interaction region of FCC-hh.

  15. Experimental demonstration of interaction region beam waist position knob for luminosity leveling

    Energy Technology Data Exchange (ETDEWEB)

    Hao, Yue [Brookhaven National Lab. (BNL), Upton, NY (United States); Bai, Mei [Inst. fuer Kernphysik, Juelich (Germany). Inst. for Advanced Simulation; Duan, Zhe [Inst. of High Energy Physics, Beijing (China); Luo, Yun [Brookhaven National Lab. (BNL), Upton, NY (United States); Marusic, Aljosa [Brookhaven National Lab. (BNL), Upton, NY (United States); Robert-Demolaize, Guillaume [Brookhaven National Lab. (BNL), Upton, NY (United States); Shen, Xiaozhe [SLAC National Accelerator Lab., Menlo Park, CA (United States)

    2015-05-03

    In this paper, we report the experimental implementation of the model-dependent control of the interaction region beam waist position (s* knob) at Relativistic Heavy Ion Collider (RHIC). The s* adjustment provides an alternative way of controlling the luminosity and is only known method to control the luminosity and reduce the pinch effect of the future eRHIC. In this paper, we will first demonstrate the effectiveness of the s* knob in luminosity controlling and its application in the future electron ion collider, eRHIC, followed by the detail experimental demonstration of such knob in RHIC.

  16. Recurrent variations of anomalous oxygen in association with a corotating interaction region

    Directory of Open Access Journals (Sweden)

    M. K. Reuss

    Full Text Available The fluxes of anomalous oxygen (E ranging from 3.5-6.8 MeV/amu, as measured by the EPAC instrument on ULYSSES, show a recurrent variation with the solar rotation period, which is anticorrelated with the fluxes of particles accelerated at the shocks of a corotating interaction region (CIR, and correlated with the fluxes of galactic cosmic rays known to be modulated by the CIR. The amplitude of this variation is much higher than expected for galactic cosmic rays of the same rigidity.

  17. High Power Radio Wave Interactions within the D-Region Ionosphere

    Science.gov (United States)

    Moore, R. C.

    2014-12-01

    This paper highlights the best results obtained during D-region modification experiments performed by the University of Florida at the High-frequency Active Auroral Research Program (HAARP) observatory between 2007 and 2014. Over this period, we have seen a tremendous improvement in ELF/VLF wave generation efficiency. We have identified methods to characterize ambient and modified ionospheric properties and to discern and quantify specific types of interactions. We have demonstrated several important implications of HF cross-modulation effects, including "Doppler Spoofing" on HF radio waves. Throughout this talk, observations are compared with the predictions of an ionospheric HF heating model to provide context and guidance for future D-region modification experiments.

  18. Interactive programs for low-flow frequency analyses for use in regional studies

    Energy Technology Data Exchange (ETDEWEB)

    Hyndman, J. R.; Huff, D. D.

    1978-08-01

    Seven-day ten-year low-flow values have been used as indices of water availability for regional energy facility siting. This paper describes an automated system for generating low-flow frequency distributions for United States Geological Survey streamflow gaging sites. Since no single frequency distribution will match the low flow frequencies at all stream gaging stations, it is necessary to examine several possible distributions for each station to determine the most useful one. Four representative low flow frequency distributions, Gumbel's limited distribution of the smallest value, the Pearson Type III, the Log-Pearson III, and the Log-Normal distributions, have been chosen for inclusion in an interactive set of programs, named LOFL02. LOFL02 forms one analysis module of the ORNL Water Analysis System (WAS), and when used in conjunction with other WAS programs makes frequency analysis viable on a regional scale by facilitating the handling of large amounts of data for large numbers of stations.

  19. Fuzzy regions in an intrinsically disordered protein impair protein-protein interactions.

    Science.gov (United States)

    Gruet, Antoine; Dosnon, Marion; Blocquel, David; Brunel, Joanna; Gerlier, Denis; Das, Rahul K; Bonetti, Daniela; Gianni, Stefano; Fuxreiter, Monika; Longhi, Sonia; Bignon, Christophe

    2016-02-01

    Despite the partial disorder-to-order transition that intrinsically disordered proteins often undergo upon binding to their partners, a considerable amount of residual disorder may be retained in the bound form, resulting in a fuzzy complex. Fuzzy regions flanking molecular recognition elements may enable partner fishing through non-specific, transient contacts, thereby facilitating binding, but may also disfavor binding through various mechanisms. So far, few computational or experimental studies have addressed the effect of fuzzy appendages on partner recognition by intrinsically disordered proteins. In order to shed light onto this issue, we used the interaction between the intrinsically disordered C-terminal domain of the measles virus (MeV) nucleoprotein (NTAIL ) and the X domain (XD) of the viral phosphoprotein as model system. After binding to XD, the N-terminal region of NTAIL remains conspicuously disordered, with α-helical folding taking place only within a short molecular recognition element. To study the effect of the N-terminal fuzzy region on NTAIL /XD binding, we generated N-terminal truncation variants of NTAIL , and assessed their binding abilities towards XD. The results revealed that binding increases with shortening of the N-terminal fuzzy region, with this also being observed with hsp70 (another MeV NTAIL binding partner), and for the homologous NTAIL /XD pairs from the Nipah and Hendra viruses. Finally, similar results were obtained when the MeV NTAIL fuzzy region was replaced with a highly dissimilar artificial disordered sequence, supporting a sequence-independent inhibitory effect of the fuzzy region.

  20. Quantum enigma physics encounters consciousness

    CERN Document Server

    Rosenblum, Bruce

    2006-01-01

    1. Presenting the Enigma2. Einstein Called it ""Spooky""--and I Wish I Had Known3. The Visit to Neg Ahne Poc: A Quantum Parable4. Our Newtonian Worldview: A Universal Law of Motion5. All the Rest of Classical PhysicsHello Quantum Mechanics6. How the Quantum Was Forced on Physics7. Schrodinger's Equation: The New Universal Law of Motion8. One-Third of Our Economy9. Our Skeleton in the Closet10. Wonderful, Wonderful Copenhagen11. Schrodinger's Controversial Cat12. Seeking a Real World: EPR13. Spooky Interactions: Bell's Theorem14. What's Going On?: Interpreting the Quantum Enigma15. The Mystery

  1. Quantum enigma physics encounters consciousness

    CERN Document Server

    Rosenblum, Bruce

    2012-01-01

    Everyone knows that sub-atomic particles have some very strange qualities. Light sometimes behaves like a particle, sometimes like a wave. Objects separated by vast distances interact faster than the speed of light – what Einstein called ‘spooky action at a distance'. Most strangely, the behaviour of objects somehow seems to be determined in retrospect, depending on what the observer is looking for. In this ground-breaking work the authors show how these quantum properties are being observed in larger and larger objects. They set out carefully and cautiously exactly what quantum theory

  2. Resonant nonlinear interactions between atmospheric waves in the polar summer mesopause region

    Institute of Scientific and Technical Information of China (English)

    LIU; Renqiang; (刘仁强); YI; Fan; (易帆)

    2003-01-01

    Data obtained from the mobile SOUSY VHF radar at And(ya/Norway in summer 1987 have been used to study the nonlinear interactions between planetary waves, tides and gravity waves in the polar mesosphere, and the instability of background atmosphere above the mesopause. It is observed that 35-h planetary wave, diurnal, semidiurnal and terdiurnal tides are the prominent perturbations in the Lomb-Scargle spectra of the zonal wind component. By inspecting the frequency combinations, several triads are identified. By bispectral analysis it is shown that most bispectral peaks stand for quadratic coupling between tidal harmonics or between tide and planetary or gravity wave, and the height dependence of bispectral peaks reflects the variation of wave-wave interactions. Above the mesopause, the occurrence heights of the maximum L-S power spectral peaks corresponding to the prominent wave components tend to increase with their frequencies. This may result from the process in which two low frequency waves interact to generate a high frequency wave. Intensities of the planetary wave and tides increase gradually, arrive at their maxima, and then decay quickly in turn with increasing height. This kind of scene correlates with a "chain" of wave-wave resonant interactions that shifts with height from lower frequency segment to higher frequency segment. By instability analysis, it is observed that above the mesopause, the Richardson number becomes smaller and smaller with height, implying that the turbulent motion grows stronger and stronger and accordingly the background atmosphere more and more instable. It is suggested that the wave-wave sum resonant interaction and the wave dissipation due to instability are two dominant dynamical processes that occur in the mesopause region. The former invokes the energy transfer from lower frequency waves to higher frequency waves. The latter results in the heating of the atmosphere and accelerating of the background flow.

  3. PARP1 Differentially Interacts with Promoter region of DUX4 Gene in FSHD Myoblasts

    Science.gov (United States)

    Sharma, Vishakha; Pandey, Sachchida Nand; Khawaja, Hunain; Brown, Kristy J; Hathout, Yetrib; Chen, Yi-Wen

    2016-01-01

    Objective The goal of the study is to identity proteins, which interact with the promoter region of double homeobox protein 4 (DUX4) gene known to be causative for the autosomal dominant disorder Facioscapulohumeral Muscular Dystrophy (FSHD). Methods We performed a DNA pull down assay coupled with mass spectrometry analysis to identify proteins that interact with a DUX4 promoter probe in Rhabdomyosarcomca (RD) cells. We selected the top ranked protein poly (ADP-ribose) polymerase 1 (PARP1) from our mass spectrometry data for further ChIP-qPCR validation using patients' myoblasts. We then treated FSHD myoblasts with PARP1 inhibitors to investigate the role of PARP1 in the FSHD myoblasts. Results In our mass spectrometry analysis, PARP1 was found to be the top ranked protein interacting preferentially with the DUX4 promoter probe in RD cells. We further validated this interaction by immunoblotting in RD cells (2-fold enrichment compared to proteins pulled down by a control probe, pfisetin (0.5 mM), a polyphenol compound with PARP1 inhibitory property, for 24 h also suppressed the expression of DUX4 (44.8 fold, p<0.01) and ZSCAN4 (2.2 fold, p<0.05) in the FSHD myoblasts. We further showed that DNA methyltransferase 1 (DNMT1), a gene regulated by PARP1 was also enriched at the DUX4 promoter in RD cells through immunoblotting (2-fold, p<0.01) and immortalized FSHD myoblasts (42-fold, p<0.01) but not control myoblasts through ChIP qPCR. Conclusion Our results showed that PARP1 and DNMT1 interacted with DUX4 promoter and may be involved in modulating DUX4 expression in FSHD. PMID:27722032

  4. Interaction between the H II region and AFGL 333-Ridge: Implications for the star formation scenario

    Science.gov (United States)

    Nakano, Makoto; Soejima, Takashi; Chibueze, James O.; Nagayama, Takumi; Omodaka, Toshihiro; Handa, Toshihiro; Sunada, Kazuyoshi; Kamezaki, Tatsuya; Burns, Ross A.

    2017-02-01

    We investigated the star formation activities in the AFGL 333 region, which is in the vicinity of the W 4 expanding bubble, by conducting NH3 (1,1), (2,2), and (3,3) mapping observations with the 45 m Nobeyama Radio Telescope an angular resolution of 75″. The morphology of the NH3 (1,1) map shows a bow-shaped structure with the size of 2.0 × 0.6 pc as seen in the dust continuum. At the interface between the W 4 bubble and the dense NH3 cloud, the compact H II region G134.2+0.8, associated with IRAS 02245+6115, is located. Interestingly, just at the north and south of G134.2+0.8 we found NH3 emission exhibiting large velocity widths of ˜2.8 km s-1, compared to 1.8 km s-1 at the other positions. As the possibility of mechanical energy injection through the activity of young stellar objects (YSOs) is low, we considered the origin of the large turbulent gas motion as an indication of interaction between the compact H II region and the periphery of the dense molecular cloud. We also found expanding motion of the CO emission associated with G134.2+0.8. The overall structure of the AFGL 333-Ridge might have been formed by the expanding bubble of W 4. However, the small velocity widths observed to the west of IRAS 02245+6115, around the center of the dense molecular cloud, suggest that interaction with the compact H II region is limited. Therefore the YSOs (dominantly Class 0/I) in the core of the AFGL 333-Ridge dense molecular cloud most likely formed in quiescent mode. As previously suggested for the large-scale star formation in the W 3 giant molecular cloud, our results show an apparent coexistence of induced and quiescent star formations in this region. It appears that star formation in the AFGL 333 region has proceeded without significant external triggers, but accompanying stellar feedback environment.

  5. Glutamate promotes SSB protein-protein Interactions via intrinsically disordered regions.

    Science.gov (United States)

    Kozlov, Alexander G; Shinn, Min Kyung; Weiland, Elizabeth A; Lohman, Timothy M

    2017-09-01

    E. coli single strand (ss) DNA binding protein (SSB) is an essential protein that binds to ssDNA intermediates formed during genome maintenance. SSB homotetramers bind ssDNA in several modes that differ in occluded site size and cooperativity. High "unlimited" cooperativity is associated with the 35 site size ((SSB)35) mode at low [NaCl], whereas the 65 site size ((SSB)65) mode formed at higher [NaCl] (> 200mM), where ssDNA wraps completely around the tetramer, displays "limited" cooperativity forming dimers of tetramers. It was previously thought that high cooperativity was associated only with the (SSB)35 binding mode. However, we show here that highly cooperative binding also occurs in the (SSB)65/(SSB)56 binding modes at physiological salt concentrations containing either glutamate or acetate. Highly cooperative binding requires the 56 amino acid intrinsically disordered C-terminal linker (IDL) that connects the DNA binding domain with the 9 amino acid C-terminal acidic tip that is involved in SSB binding to other proteins involved in genome maintenance. These results suggest that high cooperativity involves interactions between IDL regions from different SSB tetramers. Glutamate, which is preferentially excluded from protein surfaces, may generally promote interactions between intrinsically disordered regions of proteins. Since glutamate is the major monovalent anion in E. coli, these results suggest that SSB likely binds to ssDNA with high cooperativity in vivo. Copyright © 2017 Elsevier Ltd. All rights reserved.

  6. Possible interaction between thermal electrons and vibrationally excited N2 in the lower E-region

    Directory of Open Access Journals (Sweden)

    C. Z. Cheng

    2011-03-01

    Full Text Available As one of the tasks to find the energy source(s of thermal electrons, which elevate(s electron temperature higher than neutral temperature in the lower ionosphere E-region, energy distribution function of thermal electron was measured with a sounding rocket at the heights of 93–131 km by the applying second harmonic method. The energy distribution function showed a clear hump at the energy of ~0.4 eV. In order to find the reason of the hump, we conducted laboratory experiment. We studied difference of the energy distribution functions of electrons in thermal energy range, which were measured with and without EUV radiation to plasma of N2/Ar and N2/O2 gas mixture respectively. For N2/Ar gas mixture plasma, the hump is not clearly identified in the energy distribution of thermal electrons. On the other hand for N2/O2 gas mixture, which contains vibrationally excited N2, a clear hump is found when irradiated by EUV. The laboratory experiment seems to suggest that the hump is produced as a result of interaction between vibrationally excited N2 and thermal electrons, and this interaction is the most probable heating source for the electrons of thermal energy range in the lower E-region. It is also suggested that energy distribution of the electrons in high energy part may not be Maxwellian, and DC probe measures the electrons which are non Maxwellian, and therefore "electron temperature" is calculated higher.

  7. Experimental Evidence of Biological Interactions among Different Isolates of Trypanosoma cruzi from the Chaco Region

    Science.gov (United States)

    Ragone, Paula G.; Pérez Brandán, Cecilia; Monje Rumi, Mercedes; Tomasini, Nicolás; Lauthier, Juan J.; Cimino, Rubén O.; Uncos, Alejandro; Ramos, Federico; Alberti D´Amato, Anahí M.; Basombrío, Miguel A.; Diosque, Patricio

    2015-01-01

    Many infectious diseases arise from co-infections or re-infections with more than one genotype of the same pathogen. These mixed infections could alter host fitness, the severity of symptoms, success in pathogen transmission and the epidemiology of the disease. Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits a high biological variability often correlated with its genetic diversity. Here, we developed an experimental approach in order to evaluate biological interaction between three T. cruzi isolates belonging to different Discrete Typing Units (DTUs TcIII, TcV and TcVI). These isolates were obtained from a restricted geographical area in the Chaco Region. Different mixed infections involving combinations of two isolates (TcIII + TcV, TcIII + TcVI and TcV + TcVI) were studied in a mouse model. The parameters evaluated were number of parasites circulating in peripheral blood, histopathology and genetic characterization of each DTU in different tissues by DNA hybridization probes. We found a predominance of TcVI isolate in blood and tissues respect to TcIII and TcV; and a decrease of the inflammatory response in heart when the damage of mice infected with TcVI and TcIII + TcVI mixture were compared. In addition, simultaneous presence of two isolates in the same tissue was not detected. Our results show that biological interactions between isolates with different biological behaviors lead to changes in their biological properties. The occurrence of interactions among different genotypes of T. cruzi observed in our mouse model suggests that these phenomena could also occur in natural cycles in the Chaco Region. PMID:25789617

  8. Experimental evidence of biological interactions among different isolates of Trypanosoma cruzi from the Chaco Region.

    Directory of Open Access Journals (Sweden)

    Paula G Ragone

    Full Text Available Many infectious diseases arise from co-infections or re-infections with more than one genotype of the same pathogen. These mixed infections could alter host fitness, the severity of symptoms, success in pathogen transmission and the epidemiology of the disease. Trypanosoma cruzi, the etiological agent of Chagas disease, exhibits a high biological variability often correlated with its genetic diversity. Here, we developed an experimental approach in order to evaluate biological interaction between three T. cruzi isolates belonging to different Discrete Typing Units (DTUs TcIII, TcV and TcVI. These isolates were obtained from a restricted geographical area in the Chaco Region. Different mixed infections involving combinations of two isolates (TcIII + TcV, TcIII + TcVI and TcV + TcVI were studied in a mouse model. The parameters evaluated were number of parasites circulating in peripheral blood, histopathology and genetic characterization of each DTU in different tissues by DNA hybridization probes. We found a predominance of TcVI isolate in blood and tissues respect to TcIII and TcV; and a decrease of the inflammatory response in heart when the damage of mice infected with TcVI and TcIII + TcVI mixture were compared. In addition, simultaneous presence of two isolates in the same tissue was not detected. Our results show that biological interactions between isolates with different biological behaviors lead to changes in their biological properties. The occurrence of interactions among different genotypes of T. cruzi observed in our mouse model suggests that these phenomena could also occur in natural cycles in the Chaco Region.

  9. Beam dynamics of the interaction region solenoid in a linear collider due to a crossing angle

    Directory of Open Access Journals (Sweden)

    P. Tenenbaum

    2003-06-01

    Full Text Available Future linear colliders may require a nonzero crossing angle between the two beams at the interaction point (IP. This requirement in turn implies that the beams will pass through the strong interaction region solenoid with an angle, and thus that the component of the solenoidal field perpendicular to the beam trajectory is nonzero. The interaction of the beam and the solenoidal field in the presence of a crossing angle will cause optical effects not observed for beams passing through the solenoid on axis; these effects include dispersion, deflection of the beam, and synchrotron radiation effects. For a purely solenoidal field, the optical effects which are relevant to luminosity exactly cancel at the IP when the influence of the solenoid’s fringe field is taken into account. Beam size growth due to synchrotron radiation in the solenoid is proportional to the fifth power of the product of the solenoidal field, the length of the solenoid, and the crossing angle. Examples based on proposed linear collider detector solenoid configurations are presented.

  10. Interaction Between HII Region and AFGL333-Ridge: Implications to the Star Formation Scenario

    CERN Document Server

    Nakano, Makoto; Chibueze, James O; Nagayama, Takumi; Omodaka, Toshihiro; Handa, Toshihiro; Sunada, Kazuyuki; Kamezaki, Tatsuya; Burns, Ross A

    2016-01-01

    We investigated the star formation activities in the AFGL333 region, which is in the vicinity of the W4 expanding bubble, by conducting NH3 (1,1), (2,2), and (3,3) mapping observations with the 45 m Nobeyama Radio Telescope at an angular resolution of 75". The morphology of the NH3 (1,1) map shows a bow-shape structure with the size of 2.0 x 0.6 pc as seen in the dust continuum. At the interface between the W4 bubble and the dense NH3 cloud, the compact HII region G134.2+0.8, associated with IRAS02245+6115, is located. Interestingly, just north and south of G134.2+0.8 we found NH3 emission exhibiting large velocity widths of ~ 2.8 km/s, compared to 1.8 km/s at the other positions. As the possibility of mechanical energy injection through the activity of YSO(s) is low, we considered the origin of the large turbulent gas motion as indication of interaction between the compact HII region and the periphery of the dense molecular cloud. We also found expanding motion of the CO emission associated with G134.2+0.8. ...

  11. Design of an Interaction Region with Head-On Collisions for the ILC

    Energy Technology Data Exchange (ETDEWEB)

    Appleby, R.; /Cockcroft Inst. Accel. Sci. Tech. /Manchester U.; Angal-Kalinin, D.; Jackson, F.; /Daresbury; Alabau-Pons, M .; Bambade, P.; Brossard, J.; Dadoun, O.; Rimbault, C.; /Orsay, LAL; Keller, L.; Nosochkov, Y.; Seryi, A.; /SLAC; Payet, J.; Napoly, O.; Rippon, C.; Uriot, D.; /DAPNIA, Saclay

    2006-07-12

    An interaction region (IR) with head-on collisions is considered as an alternative to the baseline configuration of the International Linear Collider (ILC) which includes two IRs with finite crossing-angles (2 and 20 mrad). Although more challenging for the beam extraction, the head-on scheme is favored by the experiments because it allows a more convenient detector configuration, particularly in the forward region. The optics of the head-on extraction is revisited by separating the e+ and e- beams horizontally, first by electrostatic separators operated at their LEP nominal field and then using a defocusing quadrupole of the final focus beam line. In this way the septum magnet is protected from the beamstrahlung power. Newly optimized final focus and extraction optics are presented, including a first look at post-collision diagnostics. The influence of parasitic collisions is shown to lead to a region of stable collision parameters. Disrupted beam and beamstrahlung photon losses are calculated along the extraction elements.

  12. Dynamical Models of Interactions between Herds Forage and Water Resources in Sahelian Region

    Directory of Open Access Journals (Sweden)

    Jean Jules Tewa

    2014-01-01

    Full Text Available Optimal foraging is one of the capital topics nowadays in Sahelian region. The vast majority of feed consumed by ruminants in Sahelian region is still formed by natural pastures. Pastoral constraints are the high variability of available forage and drinking water in space and especially in time (highly seasonal, interannual variability and the scarcity of water resources. The mobility is the main functional and opportunistic adaptation to these constraints. Our goal in this paper is to formalize two dynamical models for interactions between a herd of domesticate animals, forage resources, and water resources inside a given Sahelian area, in order to confirm, explain, and predict by mathematical models some observations about pastoralism in Sahelian region. These models in some contexts can be similar to predator-prey models as forage and water resources can be considered as preys and herd’s animals as predators. These models exhibit very rich dynamics, since it predicts abrupt changes in consumer behaviour and disponibility of forage or water resources. The dynamics exhibits a possible coexistence between herd, resources, and water with alternative peaks in their trajectories.

  13. Modeling interstellar pickup ion distributions in corotating interaction regions inside 1 AU

    Science.gov (United States)

    Chen, J. H.; Schwadron, N. A.; Möbius, E.; Gorby, M.

    2015-11-01

    We present a modeling study of interstellar pickup ion (PUI) distributions in corotating interaction regions (CIRs). We consider gradual compressions associated with CIRs formed when fast speed streams overtake slower streams in the inner heliosphere. For the analysis, we adopt a simplified magnetohydrodynamic model of a CIR. The Energetic Particle Radiation Environment Module, a parallelized particle numerical kinetic code, is used to model PUI distributions using the focused transport equation, including adiabatic cooling/heating, adiabatic focusing, and parallel and perpendicular diffusion. The continuous injection of PUIs is handled as a source term with a ring distribution in velocity space that is produced from the local neutral density obtained from a hot model of the interstellar neutral gas. The simulated distributions exhibit a harder spectrum in the compression region and a softer spectrum in the rarefaction region than that in undisturbed solar wind. As an additional result, a v-5 power law tail distribution above the PUI cutoff speed (a knee in the distribution) emerges for a particular velocity gradient in the CIR. The tail above the PUI cutoff is sensitive to the CIR velocity gradient, and in one observational case studied, this relationship adequately explains the observed spectrum from 2 to 4 times the solar wind speed. This suggests that the velocity gradient associated with the CIR formation can efficiently create a seed population of PUIs before a shock forms even without stochastic acceleration. Thus, local CIR compressions without shocks may play a significant role in the acceleration process as suggested previously.

  14. Radioactivity in rocks and soil and interaction with groundwater in an arid region

    Science.gov (United States)

    Alshamsi, Dalal; Murad, Ahmed; Aldahan, Ala; Hou, Xiaolin; El Saiy, Ayman

    2014-05-01

    Interaction of groundwater with soil and rocks changes the chemical composition of the water both spatially and temporally. In arid regions, surficial recharge of groundwater is generally limited to sporadic rainfall events which may cause rapid interaction between the recharge water and the aquifers materials. Among the elements that commonly increase in concentration as groundwater interact with the aquifer materials are the radioactive elements such as uranium and thorium and their decay chain products. Here, we present data on 235U, 238U, 232Th as well as 137Cs in some sediments and rock aquifers located in the United Arab Emirates (UAE) in southeastern Arabian Peninsula. The Quaternary sediments are composed of silt, sand and gravel with varying proportions of quartz, carbonates, feldspars, evaporites, while the carbonates are mainly limestones, dolomitic limestones, dolomite and calcareous mudstones. These carbonate rocks cover ages extending from 10-230 Myr. After complete digestion using fluoric and nitric acids and chemical separation, the isotopes were measured using ICP-MS. The 235U, 238U and 232Th concentrations ranges are 2.66-32.5 ng/g, 354.7-4453 ng/g and 13.2-1367 ng/g respectively in the carbonate rocks. In the sediments the concentrations are 4.6-17.5 ng/g for 235U, 631.7-2406 ng/g for 238U and 25.6-799.6 ng/g for 232Th. Although it is difficult to quantify the amounts of uranium isotopes that enter the hydrological system from the aquifers, it seems that in the presence of carboxyl ions, uranium forms highly soluble complexes which can be transported to large distances in groundwater. The variations in 232Th concentrations are probably controlled by the availability of sulfate salt rocks (like gypsum) interacting with thorium and forming soluble thorium compounds which can also explain the highly variable concentrations in groundwater.

  15. Interrupted Stellar Encounters in Star Clusters

    CERN Document Server

    Geller, Aaron M

    2015-01-01

    Strong encounters between single stars and binaries play a pivotal role in the evolution of star clusters. Such encounters can also dramatically modify the orbital parameters of binaries, exchange partners in and out of binaries, and are a primary contributor to the rate of physical stellar collisions in star clusters. Often, these encounters are studied under the approximation that they happen quickly enough and within a small enough volume to be considered isolated from the rest of the cluster. In this paper, we study the validity of this assumption through the analysis of a large grid of single - binary and binary - binary scattering experiments. For each encounter we evaluate the encounter duration, and compare this with the expected time until another single or binary star will join the encounter. We find that for lower-mass clusters, similar to typical open clusters in our Galaxy, the percent of encounters that will be "interrupted" by an interloping star or binary may be 20-40% (or higher) in the core,...

  16. Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data

    DEFF Research Database (Denmark)

    Brorsson, C.; Hansen, Niclas Tue; Hansen, Kasper Lage;

    2009-01-01

    region were analysed in 1000 affected offspring trios generated by the Type 1 Diabetes Genetics Consortium (T1DGC). The most associated SNP in each gene was chosen and genes were mapped to ppi networks for identification of interaction partners. The association testing and resulting interacting protein...

  17. Utilizing a Low-Cost, Laser-Driven Interactive System (LaDIS) to Improve Learning in Developing Rural Regions

    Science.gov (United States)

    Liou, Wei-Kai; Chang, Chun-Yen

    2014-01-01

    This study proposes an innovation Laser-Driven Interactive System (LaDIS), utilizing general IWBs (Interactive Whiteboard) didactics, to support student learning for rural and developing regions. LaDIS is a system made to support traditional classroom practices between an instructor and a group of students. This invention effectively transforms a…

  18. STUDY ON THE PROBLEMS IN THE STAGES OF FILLING OUT THE APPLICATION FORM AND TECHNICAL-FINANCIAL REPORTING ENCOUNTERED BY THE PUBLIC INSTITUTIONS IN THE CENTRE REGION IN ACCESSING EUROPEAN FUNDS

    Directory of Open Access Journals (Sweden)

    DUMITRASCU DANUT

    2012-07-01

    Full Text Available The article has as main field the project management, specifically, identifying the negative factors on European projects. The article assumes that there is a connection between the absorption of European funds and the maturity of the Romanian society in terms of project management. The main objective of the research is to identify the problems faced by public institutions from Centre Region in accessing European funds. The purpose of the research is to identify the causes that led to the low absorption of European funds, with devastating effects on the current economic situation. The present research is based on a preliminary analysis performed by the author on the rate of accessing European funds published in an article entitled “The current state of European funds absorption through funding programmes – measure of the Romanian performances in the project management practice”. The small degree of absorption of European funds resulting from the analysis shows a poor practice of the theory on project management. To identify the causes of this problem, a research was carried out to recognise the issues that led to this situation. The investigation included two successive surveys, the first one qualitative, exploratory type, interview-based, meant to demonstrate the qualitative aspects of the investigated phenomena and the other one, quantitative, based on a questionnaire in the form of occasional surveys. The qualitative and quantitative research methods are used in combination; this approach has become necessary especially due to the very complex reality whose trueness cannot be captured through one method. The investigation has however a highly quantitative character, the purpose of the qualitative research being to provide the prerequisites for achieving the quantitative research. The qualitative research revealed the existence of some problems faced by institutions in relation to accessing and developing projects that focus

  19. Auroral effects in the D region of the ionosphere. [interactions between auroral particles and electromagnetic fields

    Science.gov (United States)

    Akasofu, S. I.

    1974-01-01

    Physical phenomena associated with the interaction between auroral particles and electromagnetic fields, auroral energy flow, and the propagation of auroral effects to low altitudes are discussed in detail. It is concluded that energy deposition of soft auroral X-rays would be negligible at stratospheric altitudes. New data from incoherent backscatter measurements of neutral winds in the auroral region indicate a lack of correlation between stratospheric winds and winds in the auroral ionosphere. Magnetograms are used to show that sector boundary crossings with a time scale of approximately one hour (as opposed to the sector structure itself with a time scale of several days) do not couple effectively with the magnetosphere and are not significant energy inputs to it.

  20. Towards a new LHC Interaction Region design for a luminosity upgrade

    CERN Document Server

    Strait, J; Limon, P; Mokhov, N V; Sen, T; Zlobin, A V; Brüning, Oliver Sim; Ostojic, R; Rossi, L; Ruggiero, F; Taylor, T; ten Kate, H; Devred, A; Gupta, R; Harrison, M; Peggs, S; Pilat, F; Caspi, S; Gourlay, S; Sabbi, G

    2003-01-01

    After the LHC operates for several years at nominal parameters, it will be necessary to upgrade it for higher luminosity. Replacing the low-beta insertions with a higher performance design based on advanced superconducting magnets is one of the most straightforward steps in this direction. Preliminary studies show that, with magnet technology that is expected to be developed by early in the next decade, a factor of 2 to 5 reduction in beta* could be achieved with new insertions, as part of an upgrade aimed at a factor of 10 luminosity increase. In this paper we survey several possible second generation LHC interaction regions designs, which address the expected limitations on LHC performance imposed by the baseline insertions.

  1. Production and performance of the LHC interaction region quadrupoles at KEK

    CERN Document Server

    Nakamoto, T; Fujii, T; Hashiguchi, E; Higashi, N; Hirano, H; Iida, M; Kanahara, T; Kimura, N; Murai, S; Odajima, W; Ogitsu, T; Ohhata, H; Ohuchi, N; Orikasa, T; Shintomi, T; Sugawara, S; Sugita, K; Tanaka, K; Terashima, A; Tsuchiya, K; Yamamoto, A

    2003-01-01

    The MQXA superconducting low-beta quadrupole magnets for the LHC interaction regions are required to generate a field gradient of up to 215 T/m at 1.9 K along an effective magnetic length of 6.37 m. After completion of an R&D program on short models and full length prototypes, the series production of magnets has started, with to date five series magnets subsequently tested at KEK. Basic characteristics such as normal training, subsequent full energy dump, thermal cycle, ramp rate dependence and temperature dependence have been studied and results indicate that magnets have satisfactory quench performance. Magnetic field measurements performed at 1.9 K show the field quality to be uniform and to satisfy the stringent beam optics requirements. (10 refs).

  2. Detection of regional DNA methylation using DNA-graphene affinity interactions.

    Science.gov (United States)

    Haque, Md Hakimul; Gopalan, Vinod; Yadav, Sharda; Islam, Md Nazmul; Eftekhari, Ehsan; Li, Qin; Carrascosa, Laura G; Nguyen, Nam-Trung; Lam, Alfred K; Shiddiky, Muhammad J A

    2017-01-15

    We report a new method for the detection of regional DNA methylation using base-dependent affinity interaction (i.e., adsorption) of DNA with graphene. Due to the strongest adsorption affinity of guanine bases towards graphene, bisulfite-treated guanine-enriched methylated DNA leads to a larger amount of the adsorbed DNA on the graphene-modified electrodes in comparison to the adenine-enriched unmethylated DNA. The level of the methylation is quantified by monitoring the differential pulse voltammetric current as a function of the adsorbed DNA. The assay is sensitive to distinguish methylated and unmethylated DNA sequences at single CpG resolution by differentiating changes in DNA methylation as low as 5%. Furthermore, this method has been used to detect methylation levels in a collection of DNA samples taken from oesophageal cancer tissues.

  3. Re-visit local coupling correction in the interaction regions of RHIC

    Energy Technology Data Exchange (ETDEWEB)

    Luo, Y.; Fischer, W.; Liu, C.; Marusic, A.; Minty, M.; Ptitsyn, V.; Schoefer, V.; Tepikian, S.; Trbojevic, D.; Zimmer, C.

    2011-11-01

    In this article we will re-visit the local coupling correction in the interaction regions (IRs) of the Relativistic Heavy Ion Collider (RHIC). We will review the measurement data of triplet quadrupole rolls, the local coupling correction strengths in the RHIC control system, and the methods for the local coupling correction with local skew quadrupole correctors. Based on the in-turnnel measurement data of triplet roll errors in 2011, we will analytically calculate and simulate IR-bump method to find out the local skew correction strengths and compare them at store and at injection with the Blue and Yellow ring lattices in the 2011 polarized proton (p-p) and Au-Au runs. The vertical dispersion from the triplet roll errors, local and global coupling correction skew quadrupoles, and the vertical dipole correctors are calculated and discussed.

  4. a Dynamically Interactive Column Physics Model Suitable for Diagnosing Regional Climate Variability and GCM Errors

    Science.gov (United States)

    Sardeshmukh, P.

    2002-12-01

    Climate diagnosis increasingly involves understanding the evolution of relatively weak signals in a high-order chaotic system of strongly interacting components. Assessing the sensitivity of the full system to perturbations (or errors) is problematic: forward "brute force" calculations are too expensive, and backward "adjoint" calculations assume linearity. Fortunately, for many specific problems it is not necessary to consider the full complexity of climate interactions; diagnosis with simpler models can be very useful. The simplification usually involves restricting the focus to component subsystems (atmosphere, ocean, land, cryosphere etc) or using models that emphasize "dynamics" over "physics" or vice versa. In growing recognition of climate sensitivity to the details of atmospheric physics, attention is increasingly turning toward diagnostic models with complex physics and simplified dynamics. Single column models (SCMs) that consider complex diabatic interactions within a single atmospheric column are the best and most extreme examples of these, and the focus of this study. For regional studies, the use of SCMs is problematic because, in part, advection by the large-scale circulation is typically decoupled from diabatic interactions. This decoupling, while apparently necessary to make an SCM workable at all, can nevertheless lead to rapid spurious error growth in SCM experiments, especially in the tropics. An SCM framework that couples the vertical advective tendencies to the column physics is developed here. Conceptually, the column is viewed as being embedded in a region of uniform background winds, temperature and humidity, which allows all fluctuating advection terms to be specified in terms of vertical velocity, temperature, and humidity. The vertical velocity at any instant is given by a formula that links the vertical temperature advection to the history of the SCM-generated diabatic heating rates up to that instant. The parameters in this coupling

  5. Low-frequency magnetic field fluctuations in Venus' solar wind interaction region: Venus Express observations

    Directory of Open Access Journals (Sweden)

    L. Guicking

    2010-04-01

    Full Text Available We investigate wave properties of low-frequency magnetic field fluctuations in Venus' solar wind interaction region based on the measurements made on board the Venus Express spacecraft. The orbit geometry is very suitable to investigate the fluctuations in Venus' low-altitude magnetosheath and mid-magnetotail and provides an opportunity for a comparative study of low-frequency waves at Venus and Mars. The spatial distributions of the wave properties, in particular in the dayside and nightside magnetosheath as well as in the tail and mantle region, are similar to observations at Mars. As both planets do not have a global magnetic field, the interaction process of the solar wind with both planets is similar and leads to similar instabilities and wave structures. We focus on the spatial distribution of the wave intensity of the fluctuating magnetic field and detect an enhancement of the intensity in the dayside magnetosheath and a strong decrease towards the terminator. For a detailed investigation of the intensity distribution we adopt an analytical streamline model to describe the plasma flow around Venus. This allows displaying the evolution of the intensity along different streamlines. It is assumed that the waves are generated in the vicinity of the bow shock and are convected downstream with the turbulent magnetosheath flow. However, neither the different Mach numbers upstream and downstream of the bow shock, nor the variation of the cross sectional area and the flow velocity along the streamlines play probably an important role in order to explain the observed concentration of wave intensity in the dayside magnetosheath and the decay towards the nightside magnetosheath. But, the concept of freely evolving or decaying turbulence is in good qualitative agreement with the observations, as we observe a power law decay of the intensity along the streamlines. The observations support the assumption of wave convection through the magnetosheath, but

  6. Humanized Tau Mice with Regionalized Amyloid Exhibit Behavioral Deficits but No Pathological Interaction

    Science.gov (United States)

    Yetman, Michael J.; Fowler, Stephanie W.; Jankowsky, Joanna L.

    2016-01-01

    Alzheimer’s disease (AD) researchers have struggled for decades to draw a causal link between extracellular Aβ aggregation and intraneuronal accumulation of microtubule-associated protein tau. The amyloid cascade hypothesis posits that Aβ deposition promotes tau hyperphosphorylation, tangle formation, cell loss, vascular damage, and dementia. While the genetics of familial AD and the pathological staging of sporadic disease support this sequence of events, attempts to examine the molecular mechanism in transgenic animal models have largely relied on models of other inherited tauopathies as the basis for testing the interaction with Aβ. In an effort to more accurately model the relationship between Aβ and wild-type tau in AD, we intercrossed mice that overproduce human Aβ with a tau substitution model in which all 6 isoforms of the human protein are expressed in animals lacking murine tau. We selected an amyloid model in which pathology was biased towards the entorhinal region so that we could further examine whether the anticipated changes in tau phosphorylation occurred at the site of Aβ deposition or in synaptically connected regions. We found that Aβ and tau had independent effects on locomotion, learning, and memory, but found no behavioral evidence for an interaction between the two transgenes. Moreover, we saw no indication of amyloid-induced changes in the phosphorylation or aggregation of human tau either within the entorhinal area or elsewhere. These findings suggest that robust amyloid pathology within the medial temporal lobe has little effect on the metabolism of wild type human tau in this model. PMID:27070146

  7. Hurricane interaction with the upper ocean in the Amazon-Orinoco plume region

    Science.gov (United States)

    Androulidakis, Yannis; Kourafalou, Vassiliki; Halliwell, George; Le Hénaff, Matthieu; Kang, Heesook; Mehari, Michael; Atlas, Robert

    2016-12-01

    The evolution of three successive hurricanes (Katia, Maria, and Ophelia) is investigated over the river plume area formed by the Amazon and Orinoco river outflows during September of 2011. The study focuses on hurricane impacts on the ocean structure and the ocean feedback influencing hurricane intensification. High-resolution (1/25° × 1/25° horizontal grid) numerical simulations of the circulation in the extended Atlantic Hurricane Region (Caribbean Sea, Gulf of Mexico, and Northwest Atlantic Ocean) were used to investigate the upper ocean response during the three hurricane-plume interaction cases. The three hurricanes revealed different evolution and intensification characteristics over an area covered by brackish surface waters. The upper ocean response to the hurricane passages over the plume affected region showed high variability due to the interaction of oceanic and atmospheric processes. The existence of a barrier layer (BL), formed by the offshore spreading of brackish waters, probably facilitated intensification of the first storm (Hurricane Katia) because the river-induced BL enhanced the resistance of the upper ocean to cooling. This effect was missing in the subsequent two hurricanes (Maria and Ophelia) as the eroded BL (due to Katia passage) allowed the upper ocean cooling to be increased. As a consequence, the amount of ocean thermal energy provided to these storms was greatly reduced, which acted to limit intensification. Numerical experiments and analyses, in tandem with observational support, lead to the conclusion that the presence of a river plume-induced BL is a strong factor in the ocean conditions influencing hurricane intensification.

  8. Spatial Interaction Modelling of Cross-Region R&D Collaborations Empirical Evidence from the EU Framework Programmes

    CERN Document Server

    Scherngell, Thomas

    2010-01-01

    The focus of this study is on cross-region R&D collaboration networks in the EU Framework Programmes (FP's). In contrast to most other empirical studies in this field, we shift attention to regions as units of analysis, i.e. we use aggregated data on research collaborations at the regional level. The objective is to identify determinants of cross-region collaboration patterns. In particular, we are interested whether geographical and technological distances are significant determinants of interregional cooperation. Further we investigate differences between intra-industry networks and public research networks (i.e. universities and research organisations). The European coverage is achieved by using data on 255 NUTS-2 regions of the 25 pre-2007 EU member-states, as well as Norway and Switzerland. We adopt a Poisson spatial interaction modelling perspective to analyse these questions. The dependent variable is the intensity of collaborative interactions between two regions, the independent variables are reg...

  9. Earth’s Interaction Region: Plasma-Neutral Interactions in the Weakly Ionized gas of Earth’s High Latitude Upper Atmosphere

    Science.gov (United States)

    Thayer, Jeffrey; Hsu, Vicki

    2015-04-01

    The high-latitude regions of Earth’s upper atmosphere are strongly influenced by plasma-neutral interactions. These interactions couple electrodynamic processes of the ionosphere with hydrodynamic processes of the more abundant thermosphere neutral gas, consequently connecting the high-latitude upper atmosphere to distant regions of the geoplasma environment. This produces a complex spatial and temporal interplay of competing processes that results in a myriad of physical and chemical responses and a rich array of neutral and plasma morphologies that constitute the high-latitude thermosphere and ionosphere. The altitude extent from the lower thermosphere to the upper ionosphere (90km - 1000km) can be considered Earth’s space-atmosphere interaction region - likened to the solar chromosphere’s interaction region where radiative processes and hydrodynamic waves from the dense lower atmosphere produce a cold lower boundary that quickly transitions over a few 100 kilometers to neutral and plasma temperatures that are five times hotter. A thousand or more kilometers further in altitude, Earth's upper atmosphere becomes a hot, collisionless, geomagnetically controlled protonosphere whose neutral and plasma population originates from the thermosphere and ionosphere. A grand challenge in the study of Earth’s interaction region is how the collision-dominated thermosphere/ionosphere system exchanges energy, mass and momentum with the collisionless magnetosphere. This talk will focus primarily on collision-dominated processes of the high-latitude ionosphere and the electromagnetic energy transfer processes that lead to frictional heating of ions and neutrals, and plasma instability phenomenon that leads to extreme electron heating. Observations of the ionosphere response to these processes will be illustrated using incoherent scatter radar measurements. Relevance to the solar chromosphere will be identified where appropriate and outstanding issues in Earth

  10. Close encounters involving free-floating planets in star clusters

    CERN Document Server

    Wang, Long; Zheng, Xiaochen; Church, Ross P; Davies, Melvyn B

    2015-01-01

    Instabilities in planetary systems can result in the ejection of planets from their host system, resulting in free-floating planets (FFPs). If this occurs in a star cluster, the FFP may remain bound to the star cluster for some time and interact with the other cluster members until it is ejected. Here, we use $N$-body simulations to characterise close star-planet and planet-planet encounters and the dynamical fate of the FFP population in star clusters containing $500-2000$ single or binary star members. We find that FFPs ejected from their planetary system at low velocities typically leave the star cluster 40% earlier than their host stars, and experience tens of close ($<1000$ AU) encounters with other stars and planets before they escape. The fraction of FFPs that experiences a close encounter depends on both the stellar density and the initial velocity distribution of the FFPs. Approximately half of the close encounters occur within the first 30 Myr, and only 10% occur after 100 Myr. The periastron vel...

  11. Huntingtin-associated protein 1 interacts with breakpoint cluster region protein to regulate neuronal differentiation.

    Directory of Open Access Journals (Sweden)

    Pai-Tsang Huang

    Full Text Available Alterations in microtubule-dependent trafficking and certain signaling pathways in neuronal cells represent critical pathogenesis in neurodegenerative diseases. Huntingtin (Htt-associated protein-1 (Hap1 is a brain-enriched protein and plays a key role in the trafficking of neuronal surviving and differentiating cargos. Lack of Hap1 reduces signaling through tropomyosin-related kinases including extracellular signal regulated kinase (ERK, resulting in inhibition of neurite outgrowth, hypothalamic dysfunction and postnatal lethality in mice. To examine how Hap1 is involved in microtubule-dependent trafficking and neuronal differentiation, we performed a proteomic analysis using taxol-precipitated microtubules from Hap1-null and wild-type mouse brains. Breakpoint cluster region protein (Bcr, a Rho GTPase regulator, was identified as a Hap1-interacting partner. Bcr was co-immunoprecipitated with Hap1 from transfected neuro-2a cells and co-localized with Hap1A isoform more in the differentiated than in the nondifferentiated cells. The Bcr downstream effectors, namely ERK and p38, were significantly less activated in Hap1-null than in wild-type mouse hypothalamus. In conclusion, Hap1 interacts with Bcr on microtubules to regulate neuronal differentiation.

  12. Cellular DDX3 regulates Japanese encephalitis virus replication by interacting with viral un-translated regions.

    Science.gov (United States)

    Li, Chen; Ge, Ling-ling; Li, Peng-peng; Wang, Yue; Dai, Juan-juan; Sun, Ming-xia; Huang, Li; Shen, Zhi-qiang; Hu, Xiao-chun; Ishag, Hassan; Mao, Xiang

    2014-01-20

    Japanese encephalitis virus is one of the most common causes for epidemic viral encephalitis in humans and animals. Herein we demonstrated that cellular helicase DDX3 is involved in JEV replication. DDX3 knockdown inhibits JEV replication. The helicase activity of DDX3 is crucial for JEV replication. GST-pulldown and co-immunoprecipitation experiments demonstrated that DDX3 could interact with JEV non-structural proteins 3 and 5. Co-immunoprecipitation and confocal microscopy analysis confirmed that DDX3 interacts and colocalizes with these viral proteins and viral RNA during the infection. We determined that DDX3 binds to JEV 5' and 3' un-translated regions. We used a JEV-replicon system to demonstrate that DDX3 positively regulates viral RNA translation, which might affect viral RNA replication at the late stage of virus infection. Collectively, we identified that DDX3 is necessary for JEV infection, suggesting that DDX3 might be a novel target to design new antiviral agents against JEV or other flavivirus infections.

  13. Merging of globular clusters within inner galactic regions. I. Do they survive the tidal interaction?

    CERN Document Server

    Miocchi, P; Matteo, P D; Vicari, A

    2006-01-01

    The main topic of this paper is the investigation of the modes of interaction of globular clusters (GCs) moving in the inner part of a galaxy. This is tackled by means of high-resolution N-body simulations, whose first results are presented in this article. Our simulations dealt with young GCs that, being presumably more massive than the presently observed ones, decayed into the inner regions of triaxial galaxies on a time much shorter than their internal relaxation time. To check the role of tidal forces, we maximised the tidal interaction considering GCs on quasi-radial orbits. The available CPU resources allowed us to follow 8 oscillations of the GCs along their orbits and the main findings are: i) clusters with an initial high enough King concentration parameter (c>=1.2), preserve up to 50% of their initial mass; ii) the inner density distribution of the survived clusters keep a King model profile; iii) GC-GC collisions have a negligible effect with respect to that caused by the passage through the galact...

  14. High Resolution Modelling of Aerosols-Meteorology Interactions over Northern Europe and Arctic regions

    Science.gov (United States)

    Mahura, Alexander; Nuterman, Roman; Baklanov, Alexander

    2017-04-01

    Aerosols have influence on weather, air quality and climate. Multi-scale modelling, and especially long-range atmospheric transport, dispersion, and deposition of aerosols from remote sources is especially challenging in northern latitudes. It is due to complexity of meteorological, chemical and biological processes, their interactions and especially within and above the surface layer, linking to climate change, and influence on ecosystems. The online integrated meteorology-chemistry-aerosols model Enviro-HIRLAM (Environment - High Resolution Limited Area Model) was employed for evaluating spatio-temporal variability of atmospheric aerosols and their interactions and effects on meteorology with a focus on the Northern Europe and Arctic regions. The model setup covers domain having 510 x 568 grids of latitude vs. longitude, horizontal resolution of 0.15 deg, 40 vertical hybrid levels, time step of 360 sec, 6 h meteorological surface data assimilation. The model was run for January and July-August 2010 at DMI's CRAY-XC30 supercomputer. Emissions used are anthropogenic (ECLIPSE v5), shipping (combined AU_RCP and FMI), wildfires (IS4FIRES), and interactive sea salt, dust and DMS. The boundary conditions were obtained from ECMWF: for meteorology (from IFS at 0.15 and 0.25 deg. for summer and winter, respectively) and atmospheric composition (from MACC Reanalysis at 1.125 deg. resolution). The Enviro-HIRLAM model was employed in 4 modes: the reference run (e.g. without aerosols influence on meteorology) and 3 modified runs (direct aerosol effect (DAE), indirect aerosol effect (IDAE), and both effects DAE and IDAE included). The differences between the reference run and the runs with mentioned aerosol effects were estimated on a day-by-day, monthly and diurnal cycle bases over the domain, Arctic areas, European and Nordic countries. The results of statistical analyses are summarized and presented.

  15. Large Amplitude IMF Fluctuations in Corotating Interaction Regions: Ulysses at Midlatitudes

    Science.gov (United States)

    Tsurutani, Bruce T.; Ho, Christian M.; Arballo, John K.; Goldstein, Bruce E.; Balogh, Andre

    1995-01-01

    Corotating Interaction Regions (CIRs), formed by high-speed corotating streams interacting with slow speed streams, have been examined from -20 deg to -36 deg heliolatitudes. The high-speed streams emanate from a polar coronal hole that Ulysses eventually becomes fully embedded in as it travels towards the south pole. We find that the trailing portion of the CIR, from the interface surface (IF) to the reverse shock (RS), contains both large amplitude transverse fluctuations and magnitude fluctuations. Similar fluctuations have been previously noted to exist within CIRs detected in the ecliptic plane, but their existence has not been explained. The normalized magnetic field component variances within this portion of the CIR and in the trailing high-speed stream are approximately the same, indicating that the fluctuations in the CIR are compressed Alfven waves. Mirror mode structures with lower intensities are also observed in the trailing portion of the CIR, presumably generated from a local instability driven by free energy associated with compression of the high-speed solar wind plasma. The mixture of these two modes (compressed Alfven waves and mirror modes) plus other modes generated by three wave processes (wave-shock interactions) lead to a lower Alfvenicity within the trailing portion of the CfR than in the high-speed stream proper. The results presented in this paper suggest a mechanism for generation of large amplitude B(sub z) fluctuations within CIRS. Such phenomena have been noted to be responsible for the generation of moderate geomagnetic storms during the declining phase of the solar cycle.

  16. Communication during gynecological out-patient encounters.

    NARCIS (Netherlands)

    Dulmen, A.M. van

    1999-01-01

    The intimate nature of women's health problems presented during gynecological encounters places great demands on gynecologists' communicative behavior. The present study examined what patients expect from their gynecologist, how gynecologists and patients actually communicate during out-patient

  17. Service encounters as bases for innovation

    DEFF Research Database (Denmark)

    Sundbo, Jon; Sundbo, Donna; Henten, Anders

    2015-01-01

    This article examines the factors affecting the innovativeness of service encounters – either as drivers or as barriers. The assumption is that a considerable number of innovations in service industries are initiated in service encounters and that employees are the core factor in connecting...... customers with the innovating organization. Based on literature studies and pilot case studies, seven propositions are proposed and tested in a qualitative, hermeneutic way in field experiments in nine service organizations. Important new results are that encounter-based innovation requires mutual empathy...... between employees and customers, employees investing stubbornness and time can be a driver for innovation, and several layers of management can be a barrier. In the field experiments three new factors for encounter-based innovation were found: translation, multitasking, and hyper-professionalism. The two...

  18. Interaction between the Supernova Remnant HB 3 and the Nearby Star-Forming Region W3

    CERN Document Server

    Zhou, Xin; Fang, Min; Su, Yang; Sun, Yan; Chen, Yang

    2016-01-01

    We performed millimeter observations in CO lines toward the supernova remnant (SNR) HB 3. Substantial molecular gas around -45 km s^-1 is detected in the conjunction region between the SNR HB 3 and the nearby W3 complex. This molecular gas is distributed along the radio continuum shell of the remnant. Furthermore, the shocked molecular gas indicated by line wing broadening features is also distributed along the radio shell and inside it. By both morphological correspondence and dynamical evidence, we confirm that the SNR HB 3 is interacting with the -45 km s^-1 molecular cloud (MC), in essence, with the nearby H II region/MC complex W3. The red-shifted line wing broadening features indicate that the remnant is located at the nearside of the MC. With this association, we could place the remnant at the same distance as the W3/W4 complex, which is 1.95 +- 0.04 kpc. The spatial distribution of aggregated young stellar object candidates (YSOc) shows a correlation to the shocked molecular strip associated with the ...

  19. Unfavorable regions in the ramachandran plot: Is it really steric hindrance? The interacting quantum atoms perspective.

    Science.gov (United States)

    Maxwell, Peter I; Popelier, Paul L A

    2017-11-05

    Accurate description of the intrinsic preferences of amino acids is important to consider when developing a biomolecular force field. In this study, we use a modern energy partitioning approach called Interacting Quantum Atoms to inspect the cause of the φ and ψ torsional preferences of three dipeptides (Gly, Val, and Ile). Repeating energy trends at each of the molecular, functional group, and atomic levels are observed across both (1) the three amino acids and (2) the φ/ψ scans in Ramachandran plots. At the molecular level, it is surprisingly electrostatic destabilization that causes the high-energy regions in the Ramachandran plot, not molecular steric hindrance (related to the intra-atomic energy). At the functional group and atomic levels, the importance of key peptide atoms (Oi-1 , Ci , Ni , Ni+1 ) and some sidechain hydrogen atoms (Hγ ) are identified as responsible for the destabilization seen in the energetically disfavored Ramachandran regions. Consistently, the Oi-1 atoms are particularly important for the explanation of dipeptide intrinsic behavior, where electrostatic and steric destabilization unusually complement one another. The findings suggest that, at least for these dipeptides, it is the peptide group atoms that dominate the intrinsic behavior, more so than the sidechain atoms. © 2017 The Authors. Journal of Computational Chemistry Published by Wiley Periodicals, Inc. © 2017 The Authors. Journal of Computational Chemistry Published by Wiley Periodicals, Inc.

  20. Uncovering the deeply embedded AGN activity in the nuclear regions of the interacting galaxy Arp299

    CERN Document Server

    Alonso-Herrero, A; Esquej, P; Gonzalez-Martin, O; Pereira-Santaella, M; Almeida, C Ramos; Levenson, N A; Packham, C; Ramos, A Asensio; Mason, R E; Espinosa, J M Rodriguez; Alvarez, C; Colina, L; Aretxaga, I; Diaz-Santos, T; Perlman, E; Telesco, C M

    2013-01-01

    We present mid-infrared (MIR) 8-13micron spectroscopy of the nuclear regions of the interacting galaxy Arp299 (IC694+NGC3690) obtained with CanariCam (CC) on the 10.4m Gran Telescopio Canarias (GTC). The high angular resolution (~0.3-0.6arcsec) of the data allows us to probe nuclear physical scales between 60 and 120pc, which is a factor of 10 improvement over previous MIR spectroscopic observations of this system. The GTC/CC spectroscopy displays evidence of deeply embedded Active Galactic Nucleus (AGN) activity in both nuclei. The GTC/CC nuclear spectrum of NGC3690/Arp299-B1 can be explained as emission from AGN-heated dust in a clumpy torus with both a high covering factor and high extinction along the line of sight. The estimated bolometric luminosity of the AGN in NGC3690 is 3.2(+/-0.6)x10^44 erg/s. The nuclear GTC/CC spectrum of IC694/Arp299-A shows 11.3micron polycyclic aromatic hydrocarbon (PAH) emission stemming from a deeply embedded (A_V~24mag) region of less than 120pc in size. There is also a con...

  1. OASIS: Ocean-Atmosphere-Sea-Ice-Snowpack Interactions in Polar Regions

    Science.gov (United States)

    Bottenheim, J. W.; Abbatt, J.; Beine, H.; Berg, T.; Bigg, K.; Domine, F.; Leck, C.; Lindberg, S.; Matrai, P.; MacDonald, R.; McConnell, J.; Platt, U.; Raspopov, O.; Shepson, P.; Shumilov, O.; Stutz, J.; Wolff, E.

    2004-05-01

    While Polar regions encompass a large part of the globe, little attention has been paid to the interactions between the atmosphere and its extensive snow-covered surfaces. Recent discoveries in the Arctic and Antarctic show that the top ten centimeters of snow is not simply a white blanket but in fact is a surprisingly reactive medium for chemical reactions in the troposphere. It has been concluded that interlinked physical, chemical, and biological mechanisms, fueled by the sun and occurring in the snow, are responsible for depletion of tropospheric ozone and gaseous mercury. At the same time production of highly reactive compounds (e.g. formaldehyde, nitrogen dioxide) has been observed at the snow surface. Air-snow interactions also have an impact on the chemical composition of the snow and hence the nature and amounts of material released in terrestrial/marine ecosystems during the melting of seasonal snow-packs. Many details of these possibly naturally occurring processes are yet to be discovered. For decades humans have added waste products including acidic particles (sulphates) and toxic contaminants such as gaseous mercury and POPs (persistent organic pollutants) to the otherwise pristine snow surface. Virtually nothing is known about transformations of these contaminants in the snowpack, making it impossible to assess the risk to the polar environment, including humans. This is especially disconcerting when considering that climate change will undoubtedly alter the nature of these transformations involving snow, ice, atmosphere, ocean, and, ultimately, biota. To address these topics an interdisciplinary group of scientists from North America, Europe and Japan is developing a set of coordinated research activities under the banner of the IGBP programs IGAC and SOLAS. The program of Ocean-Atmosphere-Sea Ice-Snowpack (OASIS) interactions has been established with a mission statement aimed at determining the impact of OASIS chemical exchange on tropospheric

  2. Complex interactions between regional dispersal of native taxa and an invasive species.

    Science.gov (United States)

    Strecker, Angela L; Arnott, Shelley E

    2010-04-01

    may alter the conditions under which species can establish. These results have implications for the interaction of native and invasive species across broad spatial scales, as regional dispersal of native taxa may forestall the local extirpation of native species. In particular, transient phases that result from variable persistence of invaders within habitats or across a region may permit native colonists to successfully establish, and thus increase local and regional resistance to future disturbance.

  3. Close Encounters of the Stellar Kind

    Science.gov (United States)

    2003-07-01

    NASA's Chandra X-ray Observatory has confirmed that close encounters between stars form X-ray emitting, double-star systems in dense globular star clusters. These X-ray binaries have a different birth process than their cousins outside globular clusters, and should have a profound influence on the cluster's evolution. A team of scientists led by David Pooley of the Massachusetts Institute of Technology in Cambridge took advantage of Chandra's unique ability to precisely locate and resolve individual sources to determine the number of X-ray sources in 12 globular clusters in our Galaxy. Most of the sources are binary systems containing a collapsed star such as a neutron star or a white dwarf star that is pulling matter off a normal, Sun-like companion star. "We found that the number of X-ray binaries is closely correlated with the rate of encounters between stars in the clusters," said Pooley. "Our conclusion is that the binaries are formed as a consequence of these encounters. It is a case of nurture not nature." A similar study led by Craig Heinke of the Harvard-Smithsonian Center for Astrophysics in Cambridge, Mass. confirmed this conclusion, and showed that roughly 10 percent of these X-ray binary systems contain neutron stars. Most of these neutron stars are usually quiet, spending less than 10% of their time actively feeding from their companion. NGC 7099 NGC 7099 A globular cluster is a spherical collection of hundreds of thousands or even millions of stars buzzing around each other in a gravitationally-bound stellar beehive that is about a hundred light years in diameter. The stars in a globular cluster are often only about a tenth of a light year apart. For comparison, the nearest star to the Sun, Proxima Centauri, is 4.2 light years away. With so many stars moving so close together, interactions between stars occur frequently in globular clusters. The stars, while rarely colliding, do get close enough to form binary star systems or cause binary stars to

  4. Volcano-rift interaction on Venus: initial results from the Beta-Atla-Themis region.

    Science.gov (United States)

    Lopez, I.; Martin-Gonzalez, F.; Marquez, A.; de Pablo, M. A.; Carreno, F.

    Extensional deformation and volcanism are widespread and geographically related processes on the surface of Venus (e.g. Head et al., 1992; Solomon et al., 1992). We report the initial results of an ongoing study on the interaction between fracture belts (chasmata and fossae) and large to intermediate-size volcanoes on Venus. The initial work focused in Beta-Atla-Themis, a region centered at ˜ 250o of longitude that covers ˜ 20 percent of the surface of the planet in which concentration of volcanic centers and fracture belts exceeds the global mean density (e.g. Crumpler et al., 1993). We carried out a survey of the volcanic features located in and close to fracture belts using existing volcano databases (Crumpler and Aubele, 2000) updated during this initial stage of our study through the analysis of full-resolution Magellan radar images for the studied region. We identified over a hundred volcanic features of different size and type (large volcanoes, intermediate-size volcanoes, steep-side domes and modified or fluted edifices) located in or near fracture belts. In this initial work, we have also established the time relationship that exist between each volcanic feature and the fracture belts and found that volcanic edifices predate, postdate or develop contemporaneously to extensional fracturing. Detailed structural mapping of locations where extensional fracturing and the formation of volcanoes is related is being carried out. In these geological settings the fracture patterns resulting from the interaction between both processes can help to constrain the different processes that operate during volcano growth (i.e. dike intrusion, chamber inflation, volcanic sagging and volcanic spreading) and its interaction with the regional stress fields responsible for the fracture belts. References: - Crumpler L.S. and J.C. Aubele (2000). Volcanism on Venus. In Encyclopedia of volcanoes, (Sigurdsson, H, B. Houghton, S.R. McNutt, H. Rymer, J. Stix, eds), p.727- 770

  5. Response of different regional online coupled models to aerosol-radiation interactions

    Science.gov (United States)

    Forkel, Renate; Balzarini, Alessandra; Brunner, Dominik; Baró, Rocio; Curci, Gabriele; Hirtl, Marcus; Honzak, Luka; Jiménez-Guerrero, Pedro; Jorba, Oriol; Pérez, Juan L.; Pirovano, Guido; San José, Roberto; Schröder, Wolfram; Tuccella, Paolo; Werhahn, Johannes; Wolke, Ralf; Žabkar, Rahela

    2016-04-01

    The importance of aerosol-meteorology interactions and their representation in online coupled regional atmospheric chemistry-meteorology models was investigated in COST Action ES1004 (EuMetChem, http://eumetchem.info/). Case study results from different models (COSMO-Muscat, COSMO-ART, and different configurations of WRF-Chem), which were applied for Europe as a coordinated exercise for the year 2010, are analyzed with respect to inter-model variability and the response of the different models to direct and indirect aerosol-radiation interactions. The main focus was on two episodes - the Russian heat wave and wildfires episode in July/August 2010 and a period in October 2010 with enhanced cloud cover and rain and including an of Saharan dust transport to Europe. Looking at physical plausibility the decrease in downward solar radiation and daytime temperature due to the direct aerosol effect is robust for all model configurations. The same holds for the pronounced decrease in cloud water content and increase in solar radiation for cloudy conditions and very low aerosol concentrations that was found for WRF-Chem when aerosol cloud interactions were considered. However, when the differences were tested for statistical significance no significant differences in mean solar radiation and mean temperature between the baseline case and the simulations including the direct and indirect effect from simulated aerosol concentrations were found over Europe for the October episode. Also for the fire episode differences between mean temperature and radiation from the simulations with and without the direct aerosol effect were not significant for the major part of the modelling domain. Only for the region with high fire emissions in Russia, the differences in mean solar radiation and temperature due to the direct effect were found to be significant during the second half of the fire episode - however only for a significance level of 0.1. The few observational data indicate that

  6. Energetic electron precipitation in weak to moderate corotating interaction region-driven storms

    Science.gov (United States)

    Ødegaard, Linn-Kristine Glesnes; Tyssøy, Hilde Nesse; Søraas, Finn; Stadsnes, Johan; Sandanger, Marit Irene

    2017-03-01

    High-energy electron precipitation from the radiation belts can penetrate deep into the mesosphere and increase the production rate of NOx and HOx, which in turn will reduce ozone in catalytic processes. The mechanisms for acceleration and loss of electrons in the radiation belts are not fully understood, and most of the measurements of the precipitating flux into the atmosphere have been insufficient for estimating the loss cone flux. In the present study the electron flux measured by the NOAA POES Medium Energy Proton and Electron Detectors 0° and 90° detectors is combined together with theory of pitch angle diffusion by wave-particle interaction to quantify the electron flux lost below 120 km altitude. Using this method, 41 weak and moderate geomagnetic storms caused by corotating interaction regions during 2006-2010 are studied. The dependence of the energetic electron precipitation fluxes upon solar wind parameters and geomagnetic indices is investigated. Nine storms give increased precipitation of >˜750 keV electrons. Nineteen storms increase the precipitation of >˜300 keV electrons, but not the >˜750 keV population. Thirteen storms either do not change or deplete the fluxes at those energies. Storms that have an increase in the flux of electrons with energy >˜300 keV are characterized by an elevated solar wind velocity for a longer period compared to the storms that do not. Storms with increased precipitation of >˜750 keV flux are distinguished by higher-energy input from the solar wind quantified by the ɛ parameter and corresponding higher geomagnetic activity.

  7. Interactions of two large antiviral polyamides with the long control region of HPV16.

    Science.gov (United States)

    Vasilieva, Elena; Niederschulte, Jacquelyn; Song, Yang; Harris, George Davis; Koeller, Kevin J; Liao, Puhong; Bashkin, James K; Dupureur, Cynthia M

    2016-08-01

    PA1 and PA25 are large hairpin polyamides that are effective in nearly eliminating HPV16 episomes (DNA) in cell culture, and PA25 has broad spectrum activity against three cancer-causing forms of HPV (Edwards, T. G., Koeller, K. J., Slomczynska, U., Fok, K., Helmus, M., Bashkin, J. K., Fisher, C., Antiviral Res. 91 (2011) 177-186). Described here are the interactions of these PAs with sequences in the long control region (LCR) of HPV16 (7348-122). Using an FeEDTA conjugate of PA1 (designed to recognize 5'-W2GW7-3'; W = A or T), 34 affinity cleavage (AC) patterns were detected for this fragment. These sites can be rationalized with sequences featuring perfect, single, double, triple and quadruple mismatches. Quantitative DNase I footprinting analysis indicates that perfect sites bind PA1 with Kds between 0.7 and 2.2 nM. Kds for single, double, triple and quadruple mismatch sites range from 1-3 nM-20 nM. Using AC and EDTA conjugates, we report that unlike smaller 8-ring hairpin PAs, introduction of a chiral turn in this large polyamide has no effect on binding orientation (forward vs. reverse). Despite its design to recognize 5'-W2GW5GW4-3' via two Im residues, a motif not represented in this HPV sequence, a PA25-EDTA conjugate yielded 31 affinity cleavage sites on the region. Low nM Kds for PA25 without EDTA indicates a high tolerance for triple and quadruple mismatches. While there is extensive coverage of the sequence examined, AC cleavage patterns for the two PAs show discrete binding events and do not overlap significantly. This indicates that within the context of A/T rich sequences, these PAs do not recognize a simple shared sequence-related feature of the DNA. These insights continue to inform the complex nature of large hairpin PA-DNA interactions and antiviral behavior.

  8. Quantifying the regional groundwater/surface water interaction based on 18O and Deuterium

    Science.gov (United States)

    Merz, Christoph; Lischeid, Gunnar; Nitzsche, Kai; Kayler, Zachary Eric

    2017-04-01

    time. First results clearly show distinct patterns of the temporal dynamics of the groundwater/surface water interaction reflecting the regional system behavior. They provide the basis for anticipating future development of the hydraulic system under climate change, and - regarding system changes - for adapted water resources management decisions.

  9. Observation of Energetic particles between a pair of Corotating Interaction Regions

    CERN Document Server

    Wu, Z; Li, G; Zhao, L L; Ebert, R W; Desai, M I; Mason, G M; Lavraud, B; Zhao, L; Liu, Y C -M; Guo, F; Tang, C L; Landi, E; Sauvaud, J

    2014-01-01

    We report observations of the acceleration and trapping of energetic ions and electrons between a pair of corotating interaction regions (CIRs). The event occurred in Carrington Rotation 2060. Observed at spacecraft STEREO-B, the two CIRs were separated by less than 5 days. In contrast to other CIR events, the fluxes of energetic ions and electrons in this event reached their maxima between the trailing-edge of the first CIR and the leading edge of the second CIR. The radial magnetic field (Br) reversed its sense and the anisotropy of the flux also changed from sunward to anti-sunward between the two CIRs. Furthermore, there was an extended period of counter-streaming suprathermal electrons between the two CIRs. Similar observations for this event were also obtained for ACE and STEREO-A. We conjecture that these observations were due to a "U-shape" large scale magnetic field topology connecting the reverse shock of the first CIR and the forward shock of the second CIR. Such a disconnected U-shaped magnetic fi...

  10. Quantifying wetland–aquifer interactions in a humid subtropical climate region: An integrated approach

    Science.gov (United States)

    Mendoza-Sanchez, Itza; Phanikumar, Mantha S.; Niu, Jie; Masoner, Jason R.; Cozzarelli, Isabelle M.; McGuire, Jennifer T.

    2013-01-01

    Wetlands are widely recognized as sentinels of global climate change. Long-term monitoring data combined with process-based modeling has the potential to shed light on key processes and how they change over time. This paper reports the development and application of a simple water balance model based on long-term climate, soil, vegetation and hydrological dynamics to quantify groundwater–surface water (GW–SW) interactions at the Norman landfill research site in Oklahoma, USA. Our integrated approach involved model evaluation by means of the following independent measurements: (a) groundwater inflow calculation using stable isotopes of oxygen and hydrogen (16O, 18O, 1H, 2H); (b) seepage flux measurements in the wetland hyporheic sediment; and (c) pan evaporation measurements on land and in the wetland. The integrated approach was useful for identifying the dominant hydrological processes at the site, including recharge and subsurface flows. Simulated recharge compared well with estimates obtained using isotope methods from previous studies and allowed us to identify specific annual signatures of this important process during the period of study (1997–2007). Similarly, observations of groundwater inflow and outflow rates to and from the wetland using seepage meters and isotope methods were found to be in good agreement with simulation results. Results indicate that subsurface flow components in the system are seasonal and readily respond to rainfall events. The wetland water balance is dominated by local groundwater inputs and regional groundwater flow contributes little to the overall water balance.

  11. Description of nuclei in the A$\\sim$100 mass region with the interacting boson model

    CERN Document Server

    Böyükata, M; Uluer, I

    2010-01-01

    Even--even nuclei in the $A\\sim100$ mass region are investigated within the framework of the interacting boson model-1 (\\mbox{IBM-1}). The study includes energy spectra and electric quadrupole transition properties of zirconium, molybdenum, ruthenium and palladium isotopes with neutron number $N\\geq52$. A global parametrization of the \\mbox{IBM-1} Hamiltonian is found leading to a description of about 300 collective levels in 30 nuclei with a root-mean-square deviation from the observed level energies of 120~keV. The importance of the $d_{5/2}$ subshell closure at neutron number $N=56$ is pointed out. The geometric character of the nuclei can be visualized by plotting the potential energy surface $V(\\beta,\\gamma)$ obtained from the \\mbox{IBM-1} Hamiltonian in the classical limit. The parametrization established on the basis of known elements is used to predict properties of the unknown, neutron-rich isotopes $^{106}$Zr, $^{112}$Mo, $^{116}$Ru and $^{122}$Pd.

  12. A Preliminary Interaction Region Design for a Super B-Factory

    CERN Document Server

    Sullivan, Michael K; Donald, Martin; Ecklund, Stanley; Novokhatski, Alexander; Seeman, John; Wienands, Ulrich

    2005-01-01

    The success of the two B-Factories (PEP-II and KEKB) has encouraged us to look at design parameters for a B-Factory with a 30-50 times increase in the luminosity of the present machines (L~1e36). In order to achieve this high luminosity, the beta y* values are reduced to 3-2 mm, the bunch spacing is minimized (0.6-0.3 m) and the bunch currents are increased. Total beam currents range from 5-25 A. The interaction region (IR) of these "SuperB" designs presents special challenges. Synchrotron radiation fans from local bending in shared magnets and from upstream sources pose difficulties due to the high power levels in these fans. High-order-mode(HOM)heating, effects that have been seen in the present B-factories, will become much more pronounced with the very short bunches and high beam currents. Masking the detector beam pipe from synchrotron radiation must take into account effects of HOM power generation. Backgrounds that are a function of the luminosity will become very important. We presen...

  13. Investigating a Possible Spectral Signature of the Wind-ISM Interaction Region of Alpha Tau

    CERN Document Server

    Wood, B E; Müller, H R; Zank, G P; Wood, Brian E.; Harper, Graham M.; Mueller, Hans-Reinhard; Zank, Gary P.

    2002-01-01

    Ultraviolet spectra from the GHRS instrument on board the Hubble Space Telescope reveal the presence of a mysterious absorption feature in the Mg II h & k lines of the nearby (d=20.0 pc) K5 III star Alpha Tau. The narrow absorption looks like an interstellar absorption feature but it is in the wrong location based on our knowledge of the local ISM flow vector. Since the absorption is close to the rest frame of the star, it has been interpreted as being from the interaction region between Alpha Tau's massive, cool wind and the interstellar medium, i.e., Alpha Tau's "astrosphere". We compute hydrodynamic models of the Alpha Tau astrosphere in order to see if the models can reproduce the Mg II absorption feature. These models do predict that stellar wind material heated, decelerated, and compressed after passing through a termination shock a few thousand AU from the star should produce a Mg II absorption feature with about the right width at roughly the right velocity. However, our first models underestimate...

  14. Radiation and Thermal Analysis of Superconducting Quadrupoles in the Interaction Region of Linear Collider

    Energy Technology Data Exchange (ETDEWEB)

    Drozhdin, A.I.; Kashikhin, V.V.; Kashikhin, V.S.; Lopes, M.L.; Mokhov, N.V.; Zlobin, A.V.; /Fermilab; Seryi, Andrei; /SLAC

    2011-10-14

    Radiation heat deposition in the superconducting magnets of the Interaction Region (IR) of a linear collider can be a serious issue that limits the magnet operating margins and shortens the material lifetime. Radiation and thermal analyses of the IR quadrupoles in the incoming and extraction beam lines of the ILC are performed in order to determine the magnet limits. This paper presents an analysis of the radial, azimuthal and longitudinal distributions of heat deposition in the incoming and disrupted beam doublets. Operation margins of the magnets based on NbTi superconductor are calculated and compared. The radiation and thermal analysis of the ILC IR quadrupoles based on Rutherford type cables was performed. It was found that the peak radiation heat deposition takes place in the second extraction quadrupole QFEX2. The maximum power density in the coil is {approx}17mW/g. This is rather high, comparing to the proton machines (LHC). However, the fast radial decay of the heat deposition together with the high thermal conductivity of the Rutherford type cable limits the coil temperatures to a moderate level. It was determined that both 2-layer and 4-layer QFEX2 magnet designs have thermal margins of a factor of {approx}4 at the nominal gradient of 31.3 T/m. Because of the large margins, these magnets can easily accommodate possible changes in the IR optics and heat deposition levels.

  15. Informing Regional Water-Energy-Food Nexus with System Analysis and Interactive Visualizations

    Science.gov (United States)

    Yang, Y. C. E.; Wi, S.

    2016-12-01

    Communicating scientific results to non-technical practitioners is challenging due to their differing interests, concerns and agendas. It is further complicated by the growing number of relevant factors that need to be considered, such as climate change and demographic dynamic. Visualization is an effective method for the scientific community to disseminate results, and it represents an opportunity for the future of water resources systems analysis (WRSA). This study demonstrates an intuitive way to communicate WRSA results to practitioners using interactive web-based visualization tools developed by the JavaScript library: Data-Driven Documents (D3) with a case study in Great Ruaha River of Tanzania. The decreasing trend of streamflow during the last decades in the region highlights the need of assessing the water usage competition between agricultural production, energy generation, and ecosystem service. Our team conduct the advance water resources systems analysis to inform policy that will affect the water-energy-food nexus. Modeling results are presented in the web-based visualization tools and allow non-technical practitioners to brush the graph directly (e. g. Figure 1). The WRSA suggests that no single measure can completely resolve the water competition. A combination of measures, each of which is acceptable from a social and economic perspective, and accepting that zero flows cannot be totally eliminated during dry years in the wetland, are likely to be the best way forward.

  16. Observations of energetic particles between a pair of corotating interaction regions

    Energy Technology Data Exchange (ETDEWEB)

    Wu, Z.; Chen, Y.; Tang, C. L. [Institute of Space Sciences and School of Space Science and Physics, Shandong University at Weihai, Weihai 264209 (China); Li, G.; Zhao, L. L. [Department of Space Science and CSPAR, University of Alabama in Huntsville, AL 35899 (United States); Ebert, R. W.; Desai, M. I. [Southwest Research Institute, San Antonio, TX 78228 (United States); Mason, G. M. [Applied Physics Laboratory, Johns Hopkins University, Laurel, MD 20723 (United States); Lavraud, B.; Sauvaud, J. [Institut de Recherche en Astrophysique et Planétologie, Université de Toulouse (UPS) and Centre National de la Recherche Scientifique, UMR 5277, Toulouse (France); Zhao, L.; Landi, E. [Department of Atmospheric, Oceanic, and Space Sciences, University of Michigan, Ann Arbor, MI 48105 (United States); Liu, Y. C.-M. [State Key Laboratory of Space Weather, National Space Science Center, CAS. Beijing 100190 (China); Guo, F., E-mail: gang.li@uah.edu [Theoretical Division, Los Alamos National Laboratory, NM 87545 (United States)

    2014-01-20

    We report observations of the acceleration and trapping of energetic ions and electrons between a pair of corotating interaction regions (CIRs). The event occurred in Carrington Rotation 2060. Observed by the STEREO-B spacecraft, the two CIRs were separated by less than 5 days. In contrast to other CIR events, the fluxes of the energetic ions and electrons in this event reached their maxima between the trailing edge of the first CIR and the leading edge of the second CIR. The radial magnetic field (B{sub r} ) reversed its sense and the anisotropy of the flux also changed from Sunward to anti-Sunward between the two CIRs. Furthermore, there was an extended period of counterstreaming suprathermal electrons between the two CIRs. Similar observations for this event were also obtained with the Advanced Composition Explorer and STEREO-A. We conjecture that these observations were due to a U-shaped, large-scale magnetic field topology connecting the reverse shock of the first CIR and the forward shock of the second CIR. Such a disconnected U-shaped magnetic field topology may have formed due to magnetic reconnection in the upper corona.

  17. Cosmic-Ray Transport in Heliospheric Magnetic Structures. II. Modeling Particle Transport through Corotating Interaction Regions

    Science.gov (United States)

    Kopp, Andreas; Wiengarten, Tobias; Fichtner, Horst; Effenberger, Frederic; Kühl, Patrick; Heber, Bernd; Raath, Jan-Louis; Potgieter, Marius S.

    2017-03-01

    The transport of cosmic rays (CRs) in the heliosphere is determined by the properties of the solar wind plasma. The heliospheric plasma environment has been probed by spacecraft for decades and provides a unique opportunity for testing transport theories. Of particular interest for the three-dimensional (3D) heliospheric CR transport are structures such as corotating interaction regions (CIRs), which, due to the enhancement of the magnetic field strength and magnetic fluctuations within and due to the associated shocks as well as stream interfaces, do influence the CR diffusion and drift. In a three-fold series of papers, we investigate these effects by modeling inner-heliospheric solar wind conditions with the numerical magnetohydrodynamic (MHD) framework Cronos (Wiengarten et al., referred as Paper I), and the results serve as input to a transport code employing a stochastic differential equation approach (this paper). While, in Paper I, we presented results from 3D simulations with Cronos, the MHD output is now taken as an input to the CR transport modeling. We discuss the diffusion and drift behavior of Galactic cosmic rays using the example of different theories, and study the effects of CIRs on these transport processes. In particular, we point out the wide range of possible particle fluxes at a given point in space resulting from these different theories. The restriction of this variety by fitting the numerical results to spacecraft data will be the subject of the third paper of this series.

  18. Complex interactions mediate the effects of fish farming on benthic chemistry within a region of Scotland.

    Science.gov (United States)

    Mayor, Daniel J; Solan, Martin

    2011-07-01

    Fish farms typically generate a localised gradient of both organic and inorganic pollutants in the underlying sediments. The factors governing the extent of such impacts remain poorly understood, particularly when multiple sites are considered. We used regression-type techniques to examine the drivers of sediment chemistry patterns around five Scottish fish farms that ranged in size (120-2106 tonnes) and fish species, but were located within farm illustrate that between-site variability can be high, even at this regional-scale. These effects must be accounted for when comparing the effects of fish farming at different locations. All measured chemical parameters declined rapidly as a function of distance from the cage edge, with the rate of decline depending on local current speeds. Only phosphorus concentrations increased directly with farm size. Increasing current speeds at farms carbon in the underlying sediments, whereas the opposite occurred at larger farms. The counterintuitive effect of current speed at farms above the threshold size suggests that the physical properties of the seabed at these locations favour the accumulation of organic wastes and/or that the underlying communities have a lower assimilative capacity. These imply that the environmental efficiency of fish farming activities may be further optimised by taking into account the interaction between current speed, substrate complexity and the functional characteristics of the benthos. Collectively, our analyses demonstrate that the fate of fish farm-derived wastes is complex and highlight the need for site-specific management techniques.

  19. FlySanDiego: a web-aware 3D interactive regional information system

    Science.gov (United States)

    Lukas, David S.; Bailey, Michael J.

    2002-03-01

    Communication of regional geographic information to the population as a whole should be a municipal priority, but sadly it is not. From traffic patterns to weather information to emergency information to proposed highways, a city or county has, in electronic form, all of this useful information and more. With the ubiquity of web browsers and the arrival of online 3D graphics technologies such as VRML and Java 3D,this information could and should be made available. By using Java andJava3D, the rendering power of an OpenGL-type application can be combined with multithreading, allowing a program to invisibly access data sets from Internet sites with dedicated threads while processing user interaction with another. Any type of relevant data can be transformed into a three-dimensional interpretation and mapped over the terrain that the user is analyzing. This prototype is designed to be extremely extensible and expandable in order to accommodate future revisions and/or portability. This paper discusses the issues surrounding the creation of such a model, along with challenges, problems, and solutions.

  20. Challenges in the professional care encounters

    DEFF Research Database (Denmark)

    Kaldal, Maiken Holm; Kristiansen, Jette; Uhrenfeldt, Lisbeth

    2017-01-01

    To prepare and guide the nursing students through their clinical periods, evidence on the students’ experiences of professional care encounters in a hospital unit, is required. A systematic review following The Joanna Briggs Institute guidelines. Five qualitative research articles were included...... are challenged by their personal boundaries in the professional care encounter and they experience a great psychological impact Patient contact is an unavoidable and complex component in the nursing education. The students have not yet built up a professional filter and are exposed to a wealth of emotional...... reactions. It is essential that the faculties prepare and guide the students before, during and after the professional care encounter to assist the development of educational strategies to prevent attrition and to the topic “The Established Relationship between the Nurse and Patient” curricula...

  1. Direct measurements of wall shear stress by buried wire gages in a shock-wave boundary-layer interaction region

    Science.gov (United States)

    Murthy, V. S.; Rose, W. C.

    1977-01-01

    Detailed measurements of wall shear stress (skin friction) were made with specially developed buried wire gages in the interaction regions of a Mach 2.9 turbulent boundary layer with externally generated shocks. Separation and reattachment points inferred by these measurements support the findings of earlier experiments which used a surface oil flow technique and pitot profile measurements. The measurements further indicate that the boundary layer tends to attain significantly higher skin-friction values downstream of the interaction region as compared to upstream. Comparisons between measured wall shear stress and published results of some theoretical calculation schemes show that the general, but not detailed, behavior is predicted well by such schemes.

  2. Predator-prey encounters in turbulent waters

    DEFF Research Database (Denmark)

    Mann, J.; Ott, Søren; Pécseli, H.L.;

    2002-01-01

    With reference to studies of predator-prey encounters in turbulent waters, we demonstrate the feasibility of an experimental method for investigations of particle fluxes to an absorbing surface in turbulent flows. A laboratory experiment is carried out, where an approximately homogeneous and isot......With reference to studies of predator-prey encounters in turbulent waters, we demonstrate the feasibility of an experimental method for investigations of particle fluxes to an absorbing surface in turbulent flows. A laboratory experiment is carried out, where an approximately homogeneous...

  3. Healthcare professionals experience with motivational interviewing in their encounter with obese pregnant women

    DEFF Research Database (Denmark)

    Lindhardt, Christina Louise; Rubak, Sune; Mogensen, Ole

    2015-01-01

    OBJECTIVE: to explore and describe how healthcare professionals in the Southern Region of Denmark experienced motivational interviewing as a communication method when working with pregnant women with obesity. DESIGN: a qualitative, descriptive study based on face-to-face interviews with 11...... a descriptive analysis methodology. FINDINGS: motivational interviewing was found to be a useful method when communicating with obese pregnant women. The method made the healthcare professionals more aware of their own communication style both when encountering pregnant women and in their interaction...... 'burned out', 'powerless' and 'stressed' as they felt they had a communication method in handling difficult workloads. CONCLUSION: healthcare professionals experienced motivational interviewing to be a useful method when working perinatally. The motivational interviewing method permitted heightened...

  4. Genome-wide occupancy profile of mediator and the Srb8-11 module reveals interactions with coding regions

    DEFF Research Database (Denmark)

    Zhu, Xuefeng; Wirén, Marianna; Sinha, Indranil

    2006-01-01

    to investigate genome-wide localization of Mediator and the Srb8-11 module in fission yeast. Mediator and the Srb8-11 module display similar binding patterns, and interactions with promoters and upstream activating sequences correlate with increased transcription activity. Unexpectedly, Mediator also interacts...... with the downstream coding region of many genes. These interactions display a negative bias for positions closer to the 5' ends of open reading frames (ORFs) and appear functionally important, because downregulation of transcription in a temperature-sensitive med17 mutant strain correlates with increased Mediator...

  5. IMMERSE: Interactive Mentoring for Multimodal Experiences in Realistic Social Encounters

    Science.gov (United States)

    2015-08-28

    val) relations, and permission levels for access to objects ranging from “no access” (0) to “can consume /destroy” (5). The motivations are...a VC, the code causes VC action, and when that role is fulfilled by the player, the code recognizes (and generally consumes ) the corresponding...being judgmental and ethnocentric . Klein, H. A. & Borders, J. – Good Stranger Diagnostic Tool ! 3 The Good Stranger Diagnostic Tool Our earlier

  6. VARIATIONS OF THE MUON FLUX AT SEA LEVEL ASSOCIATED WITH INTERPLANETARY ICMEs AND COROTATING INTERACTION REGIONS

    Energy Technology Data Exchange (ETDEWEB)

    Augusto, C. R. A.; Kopenkin, V.; Navia, C. E.; Tsui, K. H.; Shigueoka, H. [Instituto de Fisica, Universidade Federal Fluminense, 24210-346, Niteroi, RJ (Brazil); Fauth, A. C.; Kemp, E.; Manganote, E. J. T. [Instituto de Fisica Gleb Wathagin, Universidade Estadual de Campinas, Campinas, SP (Brazil); Leigui de Oliveira, M. A. [Centro de Ciencias Naturais e Humanas da Universidade Federal do ABC, Santo Andre, SP (Brazil); Miranda, P.; Ticona, R.; Velarde, A. [Instituto de Investigaciones Fisicas, UMSA, La Paz Bolivia (United States)

    2012-11-10

    We present the results of an ongoing survey on the association between the muon flux variation at ground level (3 m above sea level) registered by the Tupi telescopes (Niteri-Brazil, 22.{sup 0}9S, 43.{sup 0}2W, 3 m) and the Earth-directed transient disturbances in the interplanetary medium propagating from the Sun (such as coronal mass ejections (CME), and corotating interaction regions (CIRs)). Their location inside the South Atlantic Anomaly region enables the muon telescopes to achieve a low rigidity of response to primary and secondary charged particles. The present study is primarily based on experimental events obtained by the Tupi telescopes in the period from 2010 August to 2011 December. This time period corresponds to the rising phase of solar cycle 24. The Tupi events are studied in correlation with data obtained by space-borne detectors (SOHO, ACE, GOES). Identification of interplanetary structures and associated solar activity was based on the nomenclature and definitions given by the satellite observations, including an incomplete list of possible interplanetary shocks observed by the CELIAS/MTOF Proton Monitor on the Solar and Heliospheric Observatory (SOHO) spacecraft. Among 29 experimental events reported in the present analysis, there are 15 possibly associated with the CMEs and sheaths, and 3 events with the CIRs (forward or reverse shocks); the origin of the remaining 11 events has not been determined by the satellite detectors. We compare the observed time (delayed or anticipated) of the muon excess (positive or negative) signal on Earth (the Tupi telescopes) with the trigger time of the interplanetary disturbances registered by the satellites located at Lagrange point L1 (SOHO and ACE). The temporal correlation of the observed ground-based events with solar transient events detected by spacecraft suggests a real physical connection between them. We found that the majority of observed events detected by the Tupi experiment were delayed in

  7. The System-Supplementing Effect of the Interaction between Innovative Capacity and Institutional Environment Factors of a Region

    Directory of Open Access Journals (Sweden)

    Viktor Nikolayevich Ovchinnikov

    2016-06-01

    Full Text Available In the article, the effect of interaction between the development level of regional innovative capacity and its innovative and institutional infrastructure is traced. The research objective is to prove the hypothesis of the essential impact of the regional institutional and information environment on its innovative capacity, the identification of the effect of their systemsupplementing interaction. From the standpoint of the methodology of system-structural research its components are allocated within the innovative capacity of the regional innovative system (RIS, they are presented by a corporate sector, the structures of small and medium business, and also by the subjects of ethnic economy. The use of essential-analytical and functional approaches has revealed the leading role of intangible assets of the corporate sector of the economy in region’s innovative development. The correlation and regression analysis has confirmed the essential dependence of the innovative activity of the region on the systemic completeness of the development of its institutional and infrastructure environment. The results of the research have shown that to ensure the system-supplementing effect of the interaction between innovative capacity and the factors of its activation in the sphere of institutional infrastructure, it is necessary to consistently develop its operational base — the institutions of RIS. The recommendations reasoned in the article may be used for the development of regional innovation strategies, the formation of innovation clusters. The three-component structure of the innovation cluster of the region is offered; its integrating function in relation to the innovative components of the regional sectoral clusters is determined. The factors constraining the growth of innovation activity of the regional economic subjects are revealed and the recommendations on the development of the institutional and infrastructural environment of the Rostov

  8. Dynamics of a stressful encounter: cognitive appraisal, coping, and encounter outcomes.

    Science.gov (United States)

    Folkman, S; Lazarus, R S; Dunkel-Schetter, C; DeLongis, A; Gruen, R J

    1986-05-01

    Despite the importance that is attributed to coping as a factor in psychological and somatic health outcomes, little is known about actual coping processes, the variables that influence them, and their relation to the outcomes of the stressful encounters people experience in their day-to-day lives. This study uses an intraindividual analysis of the interrelations among primary appraisal (what was at stake in the encounter), secondary appraisal (coping options), eight forms of problem- and emotion-focused coping, and encounter outcomes in a sample of community-residing adults. Coping was strongly related to cognitive appraisal; the forms of coping that were used varied depending on what was at stake and the options for coping. Coping was also differentially related to satisfactory and unsatisfactory encounter outcomes. The findings clarify the functional relations among appraisal and coping variables and the outcomes of stressful encounters.

  9. Sixth Graders Speak Out: Troublesome Intercultural Encounters.

    Science.gov (United States)

    Jaasma, Marjorie A.

    Researchers have pointed to cultural diversity as a major source of conflict in our nation's schools, noting that these conflicts have the potential to escalate into violence. This study seeks to identify the types of intercultural encounters that young people themselves find troublesome. Participants were 906 sixth graders in 12 elementary…

  10. Managing Complaints in Multilingual Care Encounters

    Science.gov (United States)

    Jansson, Gunilla; Wadensjö, Cecilia; Plejert, Charlotta

    2017-01-01

    Troubles-telling and complaints are common in contexts of care for older people and need to be managed by care staff in a respectful manner. This paper examines the handling of an older person's complaints in multilingual care encounters that involve participants who do not share a common language. The data consist of video-recordings and…

  11. Entering a Crack: An Encounter with Gossip

    Science.gov (United States)

    Henderson, Linda

    2014-01-01

    In this paper, I enter a crack to think otherwise about the concept "gossip". Drawing on previous scholarship engaging with Deleuzian concepts to inform research methodologies, this paper builds on this body of work. Following Deleuze and Guattari, the paper undertakes a mapping of gossip, subsequent to an encounter with a crack.…

  12. 69 70 THE PHONOLOGICAL PROBLEMS ENCOUNTERED BY ...

    African Journals Online (AJOL)

    Dr Ike

    2007-05-10

    May 10, 2007 ... This paper examines the phonological problems Nigerian students speaking Igbo language encounter in learning the Chinese language. Introduction ..... Jiao, F. A Chinese-English Dictionary of Measure Words. Beijing: Sinolingua, 2001. Lyons, J. Language and Linguistics: An Introduction. England:.

  13. Moral Relations in Encounters with Nature

    Science.gov (United States)

    Andersson, Karin; Öhman, Johan

    2015-01-01

    The overall aim of this article is to develop in-depth knowledge about the connection between outdoor experiences and moral attitudes towards nature. The study focuses on processes in which moral relations are at stake in encounters between students and nature. The purpose is to identify such events, describe their specific circumstances and…

  14. Encountering Pedagogy through Relational Art Practices

    Science.gov (United States)

    Irwin, Rita L.; O'Donoghue, Donal

    2012-01-01

    Two artists involved in "socially engaged art" practice were invited to work with art education teacher candidates and instructors in an effort to rethink notions of teaching, learning and art. We initiated this residency, which we called "The Summerhill Residency", to examine how learning encounters might create environments…

  15. Domestic Violence Encountered among Kurdish Women

    Science.gov (United States)

    Ali, Sirwan Kamil

    2015-01-01

    Background and objective; There is growing recognition that violence against women has a large public health impact, in addition to being a gross violation of women's human rights. The study's aims were: To show the types of domestic abuse encountered by Kurdish women, and study the relationship between them. Methods; The study conducted in the…

  16. Encounters on a Shape-changing Bench

    DEFF Research Database (Denmark)

    Kinch, Sofie; Grönvall, Erik; Petersen, Marianne Graves;

    2014-01-01

    ; a concert hall, an airport and a shopping mall. We gathered insights from more than 120 people, as they unexpectedly encountered the shape changing capabilities of the bench. By taking the user tests out of the lab and into the wild, we explored the influence of context on the users experience of a shape...

  17. Primary lumbar hernia: A rarely encountered hernia

    Directory of Open Access Journals (Sweden)

    Sharada Sundaramurthy

    2016-01-01

    Conclusion: A surgeon may encounter a primary lumbar hernia perhaps once in his lifetime making it an interesting surgical challenge. Sound anatomical knowledge and adequate imaging are indispensable. Inspite of advances in minimally invasive surgery, it cannot be universally applied to patients with lumbar hernia and management requires a more tailored approach.

  18. Entering a Crack: An Encounter with Gossip

    Science.gov (United States)

    Henderson, Linda

    2014-01-01

    In this paper, I enter a crack to think otherwise about the concept "gossip". Drawing on previous scholarship engaging with Deleuzian concepts to inform research methodologies, this paper builds on this body of work. Following Deleuze and Guattari, the paper undertakes a mapping of gossip, subsequent to an encounter with a crack.…

  19. Moral Relations in Encounters with Nature

    Science.gov (United States)

    Andersson, Karin; Öhman, Johan

    2015-01-01

    The overall aim of this article is to develop in-depth knowledge about the connection between outdoor experiences and moral attitudes towards nature. The study focuses on processes in which moral relations are at stake in encounters between students and nature. The purpose is to identify such events, describe their specific circumstances and…

  20. Children's collaborative encounters in pre-school

    DEFF Research Database (Denmark)

    Svinth, Lone

    2013-01-01

    ’s collaboration and how the institutional demands influence children’s collaborative encounters. The study is based on video recordings of paedagogical activities (workshops and circle times) in two Danish pre-schools over a period of 11 months. Although institutional demands challenge children’s initiatives...

  1. A Web-Based Modelling Platform for Interactive Exploration of Regional Responses to Global Change

    Science.gov (United States)

    Holman, I.

    2014-12-01

    Climate change adaptation is a complex human-environmental problem that is framed by the uncertainty in impacts and the adaptation choices available, but is also bounded by real-world constraints such as future resource availability and environmental and institutional capacities. Educating the next generation of informed decision-makers that will be able to make knowledgeable responses to global climate change impacts requires them to have access to information that is credible, accurate, easy to understand, and appropriate. However, available resources are too often produced by inaccessible models for scenario simulations chosen by researchers hindering exploration and enquiry. This paper describes the interactive exploratory web-based CLIMSAVE Integrated Assessment (IA) Platform (www.climsave.eu/iap) that aims to democratise climate change impacts, adaptation and vulnerability modelling. The regional version of the Platform contain linked simulation models (of the urban, agriculture, forestry, water and biodiversity sectors), probabilistic climate scenarios and socio-economic scenarios, that enable users to select their inputs (climate and socioeconomic), rapidly run the models using their input variable settings and view their chosen outputs. The interface of the CLIMSAVE IA Platform is designed to facilitate a two-way iterative process of dialogue and exploration of "what if's" to enable a wide range of users to improve their understanding surrounding impacts, adaptation responses and vulnerability of natural resources and ecosystem services under uncertain futures. This paper will describe the evolution of the Platform and demonstrate how using its holistic framework (multi sector / ecosystem service; cross-sectoral, climate and socio-economic change) will help to assist learning around the challenging concepts of responding to global change.

  2. Interaction between the tidal and seasonal variability of the Gulf of Maine and Scotian Shelf region

    Science.gov (United States)

    Katavouta, Anna; Thompson, Keith; Lu, Youyu; Loder, John

    2017-04-01

    In the Gulf of Maine and Scotian Shelf (off the northeastern coast of North America) tides are large and can alter the local hydrographic properties, circulation, and sea surface height through processes such as tidal rectification, mixing, and horizontal advection. Furthermore, the stratification of the water column can influence tidal elevation and currents over the shelves (e.g., baroclinic tides). To investigate this interaction, a newly developed high resolution (1/36 degree) regional circulation model is used (GoMSS model). First, numerical experiments with and without density stratification are used to demonstrate the influence of stratification on the tides. GoMSS model is then used to interpret the physical mechanisms responsible for the largest seasonal variations in the M2 surface current which occur over, and to the north of, Georges Bank. An alternating pattern of highs and lows in the summer maximum M2 surface speed in the Gulf of Maine is identified, for the first time, in both the model output and observations by a high frequency coastal radar system. This pattern consists of extended striations in tidal speed aligned with the northern flank of Georges Bank that separates the Gulf of Maine from the North Atlantic. The striations are explained in terms of a linear superposition of the barotropic tide flowing across the northern flank of Georges Bank and the reflected, phase-locked baroclinic tide. The striations have amplitudes of about 0.1 m/s and longitudinal length scales of order 100 km, and are thus of practical significance.

  3. Mildly negative social encounters reduce physical pain sensitivity.

    Science.gov (United States)

    Borsook, Terry K; MacDonald, Geoff

    2010-11-01

    While previous research has demonstrated a reduction in physical pain sensitivity in response to social exclusion, the manipulations employed have arguably been far removed from typical daily experience. The purpose of this study was to investigate the effects of relatively ordinary social encounters on the perception of pain. Healthy participants rated the intensity and unpleasantness of painful stimuli before and after engaging in a structured interaction with a confederate who was instructed to either be warm and friendly or indifferent. A control group was asked to perform a similar structured activity, but alone. Consistent with predictions, participants who experienced the mildly negative social exchange reported lower pain intensity and unpleasantness after the encounter relative to baseline, whereas those exposed to the positive social exchange did not evidence any change in pain ratings. These results were not mediated by changes in mood or perceived connectedness. If mildly negative social encounters can provoke an analgesic effect, it is possible that social hypoalgesia may be considerably more commonplace than previously realized. Discussion focuses on the role of stress-induced hypoalgesia, and the implications of the results for clinical assessments of pain.

  4. Viral video: Live imaging of virus-host encounters

    Science.gov (United States)

    Son, Kwangmin; Guasto, Jeffrey S.; Cubillos-Ruiz, Andres; Chisholm, Sallie W.; Sullivan, Matthew B.; Stocker, Roman

    2014-11-01

    Viruses are non-motile infectious agents that rely on Brownian motion to encounter and subsequently adsorb to their hosts. Paradoxically, the viral adsorption rate is often reported to be larger than the theoretical limit imposed by the virus-host encounter rate, highlighting a major gap in the experimental quantification of virus-host interactions. Here we present the first direct quantification of the viral adsorption rate, obtained using live imaging of individual host cells and viruses for thousands of encounter events. The host-virus pair consisted of Prochlorococcus MED4, a 800 nm small non-motile bacterium that dominates photosynthesis in the oceans, and its virus PHM-2, a myovirus that has a 80 nm icosahedral capsid and a 200 nm long rigid tail. We simultaneously imaged hosts and viruses moving by Brownian motion using two-channel epifluorescent microscopy in a microfluidic device. This detailed quantification of viral transport yielded a 20-fold smaller adsorption efficiency than previously reported, indicating the need for a major revision in infection models for marine and likely other ecosystems.

  5. Toward Construction of the Unified Lepton-Nucleus Interaction Model from a Few Hundred MeV to GeV Region

    CERN Document Server

    Nakamura, S X; Hirai, M; Kamano, H; Kumano, S; Sakuda, M; Saito, K; Sato, T

    2013-01-01

    Next generation neutrino oscillation experiments will need a quantitative understanding of neutrino-nucleus interaction far better than ever. Kinematics covered by the relevant neutrino-nucleus interaction spans wide region, from the quasi-elastic, through the resonance region, to the deeply inelastic scattering region. The neutrino-nucleus interaction in each region has quite different characteristics. Obviously, it is essential to combine different expertise to construct a unified model that covers all the kinematical region of the neutrino-nucleus interaction. Recently, several experimentalists and theorists got together to form a collaboration to tackle this problem. In this contribution, we report the collaboration's recent activity and a goal in near future.

  6. Interaction-Point Phase-Space Characterization using Single-Beam and Luminous-Region Measurements at PEP-II

    Energy Technology Data Exchange (ETDEWEB)

    Kozanecki, W; /Saclay; Bevan, A.J.; /Queen Mary, U. of London; Viaud, B.F.; /Montreal U.; Cai, Y.; Fisher, A.S.; O' Grady, C.; Lindquist, B.; Roodman, A.; J.M.Thompson, M.Weaver; /SLAC

    2008-09-09

    We present an extensive experimental characterization of the e{sup {+-}} phase space at the interaction point of the SLAC PEP-II B-Factory, that combines a detailed mapping of luminous-region observables using the BABAR detector, with stored-beam measurements by accelerator techniques.

  7. Main Effects of Diagnoses, Brain Regions, and their Interaction Effects for Cerebral Metabolites in Bipolar and Unipolar Depressive Disorders

    Science.gov (United States)

    Tan, Hai-Zhu; Li, Hui; Liu, Chen-Feng; Guan, Ji-Tian; Guo, Xiao-Bo; Wen, Can-Hong; Ou, Shao-Min; Zhang, Yin-Nan; Zhang, Jie; Xu, Chong-Tao; Shen, Zhi-Wei; Wu, Ren-Hua; Wang, Xue-Qin

    2016-11-01

    Previous studies suggested patients with bipolar depressive disorder (BDd) or unipolar depressive disorder (UDd) have cerebral metabolites abnormalities. These abnormalities may stem from multiple sub-regions of gray matter in brain regions. Thirteen BDd patients, 20 UDd patients and 20 healthy controls (HC) were enrolled to investigate these abnormalities. Absolute concentrations of 5 cerebral metabolites (glutamate-glutamine (Glx), N-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), creatine (Cr), parietal cortex (PC)) were measured from 4 subregions (the medial frontal cortex (mPFC), anterior cingulate cortex (ACC), posterior cingulate cortex (PCC), and parietal cortex (PC)) of gray matter. Main and interaction effects of cerebral metabolites across subregions of gray matter were evaluated. For example, the Glx was significantly higher in BDd compared with UDd, and so on. As the interaction analyses showed, some interaction effects existed. The concentrations of BDds’ Glx, Cho, Cr in the ACC and HCs’ mI and Cr in the PC were higher than that of other interaction effects. In addition, the concentrations of BDds’ Glx and Cr in the PC and HCs’ mI in the ACC were statistically significant lower than that of other interaction effects. These findings point to region-related abnormalities of cerebral metabolites across subjects with BDd and UDd.

  8. Regulatory R region of the CFTR chloride channel is a dynamic integrator of phospho-dependent intra- and intermolecular interactions.

    Science.gov (United States)

    Bozoky, Zoltan; Krzeminski, Mickael; Muhandiram, Ranjith; Birtley, James R; Al-Zahrani, Ateeq; Thomas, Philip J; Frizzell, Raymond A; Ford, Robert C; Forman-Kay, Julie D

    2013-11-19

    Intrinsically disordered proteins play crucial roles in regulatory processes and often function as protein interaction hubs. Here, we present a detailed characterization of a full-length disordered hub protein region involved in multiple dynamic complexes. We performed NMR, CD, and fluorescence binding studies on the nonphosphorylated and highly PKA-phosphorylated human cystic fibrosis transmembrane conductance regulator (CFTR) regulatory region, a ∼200-residue disordered segment involved in phosphorylation-dependent regulation of channel trafficking and gating. Our data provide evidence for dynamic, phosphorylation-dependent, multisite interactions of various segments of the regulatory region for its intra- and intermolecular partners, including the CFTR nucleotide binding domains 1 and 2, a 42-residue peptide from the C terminus of CFTR, the SLC26A3 sulphate transporter and antisigma factor antagonist (STAS) domain, and 14-3-3β. Because of its large number of binding partners, multivalent binding of individually weak sites facilitates rapid exchange between free and bound states to allow the regulatory region to engage with different partners and generate a graded or rheostat-like response to phosphorylation. Our results enrich the understanding of how disordered binding segments interact with multiple targets. We present structural models consistent with our data that illustrate this dynamic aspect of phospho-regulation of CFTR by the disordered regulatory region.

  9. Rational Design of Coumarin Derivatives as CK2 Inhibitors by Improving the Interaction with the Hinge Region.

    Science.gov (United States)

    Zhang, Na; Chen, Wen-Juan; Zhou, Yue; Zhao, Hongtao; Zhong, Ru-Gang

    2016-01-01

    Design of novel coumarin derivatives as CK2 inhibitors were attempted by targeting the interaction with the hinge region. A set of substituents capable of forming a hydrogen bond or halogen bond with the hinge region were screened in silico, and trifluoromethyl emerges as a promising motif by forming favorable electrostatic interaction and a presumable halogen bond with the hinge region. As proof of concept, three trifluoromethyl derivatives of coumarin were synthesized and tested in vitro. The results indicated that replacement of methyl by trifluoromethyl leads to a modest 5-fold improvement in potency, with the most active compound being 0.4 µM. The newly designed compounds were further screened on one lung cancer cell line A549, showing low micromolar anti-proliferative activity.

  10. Functional regions of Candida albicans hyphal cell wall protein Als3 that determine interaction with the oral bacterium Streptococcus gordonii.

    Science.gov (United States)

    Bamford, Caroline V; Nobbs, Angela H; Barbour, Michele E; Lamont, Richard J; Jenkinson, Howard F

    2015-01-01

    The opportunistic pathogen Candida albicans colonizes the oral cavity and gastrointestinal tract. Adherence to host cells, extracellular matrix and salivary glycoproteins that coat oral surfaces, including prostheses, is an important prerequisite for colonization. In addition, interactions of C. albicans with commensal oral streptococci are suggested to promote retention and persistence of fungal cells in mixed-species communities. The hyphal filament specific cell wall protein Als3, a member of the Als protein family, is a major determinant in C. albicans adherence. Here, we utilized site-specific in-frame deletions within Als3 expressed on the surface of heterologous Saccharomyces cerevisiae to determine regions involved in interactions of Als3 with Streptococcus gordonii. N-terminal region amino acid residue deletions Δ166-225, Δ218-285, Δ270-305 and Δ277-286 were each effective in inhibiting binding of Strep. gordonii to Als3. In addition, these deletions differentially affected biofilm formation, hydrophobicity, and adherence to silicone and human tissue proteins. Deletion of the central repeat domain (Δ434-830) did not significantly affect interaction of Als3 with Strep. gordonii SspB protein, but affected other adherence properties and biofilm formation. Deletion of the amyloid-forming region (Δ325-331) did not affect interaction of Als3 with Strep. gordonii SspB adhesin, suggesting this interaction was amyloid-independent. These findings highlighted the essential function of the N-terminal domain of Als3 in mediating the interaction of C. albicans with S. gordonii, and suggested that amyloid formation is not essential for the inter-kingdom interaction.

  11. Application of electromagnetic-wave-ionospheric interactions to global warming in the arctic region

    Science.gov (United States)

    Wong, A. Y.

    An approach to expel pollutants which can contribute to global warming from the upper atmosphere by the use of HF electromagnetic waves has been proposed [1]. Laboratory plasma experiments have shown that significant gyro-resonance acceleration of minority ion species in a plasma is possible. The separation of ions differing in mass by one unit has been achieved. This method is applicable to the selective acceleration of ions perpendicular to the geomagnetic field in the ionosphere and involves the modulation of the auroral electrojet current to excite ion cyclotron waves. On account of the divergent geomagnetic field in the polar atmosphere the accelerated perpendicular ion velocity is converted into an upward motion along open magnetic field lines. The ions thus removed will not return to the upper atmosphere. Negatively charged particles move upward by the fair-weather electric field and by atmospheric convection. When ions reach above 120˜ km altitude where the ion gyro-frequency is comparable to or greater than the ion-neutral collision frequency, they can be accelerated by electromagnetic fields through the gyro-resonance interaction. By modulating the auroral electrojet in the gyro-frequency range for important minority ion species (˜ 15--30 Hz for CO2-, and Cl-) electromagnetic ion cyclotron waves can be excited, which propagate nearly along the geomagnetic field lines. Experimental evidence for this effect has been obtained with the HIPAS facility [Wong et al., 1997]. When exciting ELF waves over a range of ion gyro-frequencies of dominant ion species, dips were observed in magnetometer data at ion gyro-frequencies of various species, which suggests that the ELF wave energy was absorbed by ions. Similar ion acceleration and expelling phenomenon over the polar regions occurs naturally in so called ion conics as observed by high latitude satellites. Field aligned currents might provide the free energy needed to make this process practical. Field

  12. TAXPAYERS AND TAX AUTHORITIES INTERACTING WITHIN THE MENA REGION: THE NEXUS BETWEEN TRUST, POWER AND COMPLIANCE

    Directory of Open Access Journals (Sweden)

    Batrancea Larissa

    2014-12-01

    Full Text Available Any type of interaction climate, be it synergistic or antagonistic, is delineated by a tandem of dimensions: trust in authorities and power of authorities. Advocates for this assumption are the manifold of empirical studies testing the “slippery slope framework” which subsumes the two dimensions. A major proffer advanced by the framework is that tax authorities’ approach towards citizens poses great influence on compliance, either fuelling or hindering it. Irrespective of whether tax burden level is high (e.g., Scandinavian, Continental welfare states, medium (e.g., East European, Anglo-Saxon welfare states, minimum or completely lacking (e.g., tax havens, tax authorities and taxpayers establish a connection in which the former’s actions are mirrored in the latter’s perceptions about leadership’s benevolence in public good provisions (i.e., trust and efficiency in deterring tax evasion (i.e., power. The tandem trust-power and the specific features of such connections within some countries of the Middle East and Northern Africa tax climate (i.e., Bahrain, Egypt, Iran, Jordan, Kuwait, Morocco, Oman, Qatar, Saudi Arabia, United Arab Emirates are the thrust of the present study. The methodology spans a multidisciplinary approach, from explaining trust and power via governance indicators proposed by the World Bank, investigating economic development with chain base indexes and examining tax compliance process on country-level. The MENA region is source for novel and relevant insights on the nexus between trust, power and compliance, as it hosts countries which vary greatly in terms of economic development (transition to developed, fiscal policy (low to no taxes or economy drivers (oil exporters, oil importers and where tax compliance gains importance amid diminishing hydrocarbon resources. Nowadays economic realities constrain MENA authorities to refocus their governing strategies and perceive taxation as a viable future solution for

  13. Local and regional interactions between air quality and climate in New Delhi- A sector based analysis

    Science.gov (United States)

    Marrapu, Pallavi

    Deteriorating air quality is one of the major problems faced worldwide and in particular in Asia. The world's most polluted megacities are located in Asia highlighting the urgent need for efforts to improve the air quality. New Delhi (India), one of the world's most polluted cities, was the host of the Common Wealth Games during the period of 4-14 October 2010. This high profile event provided a good opportunity to accelerate efforts to improve air quality. Computational advances now allow air quality forecast models to fully couple the meteorology with chemical constituents within a unified modeling system that allows two-way interactions. The WRF-Chem model is used to simulate air quality in New Delhi. The thesis focuses on evaluating air quality and meteorology feedbacks. Four nested domains ranging from South Asia, Northern India, NCR Delhi and Delhi city at 45km, 15km, 5km and 1.67km resolution for a period of 20 day (26th Sep--15th Oct, 2010) are used in the study. The predicted mean surface concentrations of various pollutants show similar spatial distributions with peak values in the middle of the domain reflecting the traffic and population patterns in the city. Along with these activities, construction dust and industrial emissions contribute to high levels of criteria pollutants. The study evaluates the WRF-Chem capabilities using a new emission inventory developed over Delhi at a fine resolution of 1.67km and evaluating the results with observational data from 11 monitoring sties placed at various Game venues. The contribution of emission sectors including transportation, power, industry, and domestic to pollutant concentrations at targeted regions are studied and the results show that transportation and domestic sector are the major contributors to the pollution levels in Delhi, followed by industry. Apart from these sectors, emissions outside of Delhi contribute 20-50% to surface concentrations depending on the species. This indicates that pollution

  14. The interaction between the membrane-proximal external region and the N-trimer region of HIV- 1 gp41: Involvement in viral fusion

    Institute of Scientific and Technical Information of China (English)

    LI Jing; LU Lu; WU Fan; CHEN Xi; NIU Ben; JIANG ShiBo; CHEN YingHua

    2009-01-01

    The membrane proximal external region (MPER) of gp41 is extremely conserved among diverse HIV-1 variants, implying its important role in viral infection. Interestingly, two of the most broadly neutralizing antibodies, 2F5 and 4E10, specifically recognize this region. Our previous study demonstrated that the antigenicity and immunogenicity of 4E10 epitope are affected by remodeling gp41 fusion core, sug-gesting that the MPER may be associated with gp41 core and involved in gp41-mediated membrane fusion. Here we measured the binding activity of 4E10 epitope peptide (D4E10P) with various gp41 core-derived peptides and found that the N-trimer region in a construct designated N-trimer-6HB in-teracted significantly with D4E10P. Using N-trimer-6HB to screen a phage library, we identified a motif (WF) located in 4E10 epitope that may play a certain role in the interaction of gp41 MPER with the N-trimer in gp41 fusion core and, we thus speculated upon the potential involvement of MPER in the usion process between viral envelope and target cell membrane.

  15. Mobbing behaviors encountered by nurse teaching staff.

    Science.gov (United States)

    Yildirim, Dilek; Yildirim, Aytolan; Timucin, Arzu

    2007-07-01

    The term 'mobbing' is defined as antagonistic behaviors with unethical communication directed systematically at one individual by one or more individuals in the workplace. This cross-sectional and descriptive study was conducted for the purpose of determining the mobbing behaviors encountered by nursing school teaching staff in Turkey, its effect on them, and their responses to them. A large percentage (91%) of the nursing school employees who participated in this study reported that they had encountered mobbing behaviors in the institution where they work and 17% that they had been directly exposed to mobbing in the workplace. The academic staff who had been exposed to mobbing behaviors experienced various physiological, emotional and social reactions. They frequently 'worked harder and [were] more organized and worked very carefully to avoid criticism' to escape from mobbing. In addition, 9% of the participants stated that they 'thought about suicide occasionally'.

  16. Winnicott and Lacan: a missed encounter?

    Science.gov (United States)

    Vanier, Alain

    2012-04-01

    Winnicott was able to say that Lacan's paper on the mirror stage "had certainly influenced" him, while Lacan argued that he found his object a in Winnicott's transitional object. By following the development of their personal relations, as well as of their theoretical discussions, it is possible to argue that this was a missed encounter--yet a happily missed one, since the misunderstandings of their theoretical exchanges allowed each of them to clarify concepts otherwise difficult to discern.

  17. Investigation of Wake-Vortex Aircraft Encounters

    Science.gov (United States)

    Smith, Sonya T.

    1999-01-01

    The National Aeronautics and Space Administration is addressing airport capacity enhancements during instrument meteorological conditions though the Terminal Area Productivity (TAP) program. The major goal of the TAP program is to develop the technology that will allow air traffic levels during instrument meteorological condition to approach those achieved during visual operations. The Reduced Spacing Operations (RSO) subelement of TAP at the NASA Langley Research Center (LaRC) will develop the Aircraft Vortex Spacing System (AVOSS). The purpose of the AVOSS is to integrate current and predicted weather conditions, wake vortex transport and decay knowledge, wake vortex sensor data, and operational definitions of acceptable strengths for vortex encounters to produce dynamic wake vortex separation criteria. The proposed research is in support of the wake vortex hazard definition component of the LaRC AVOSS development research. The research program described in the next section provided an analysis of the static test data and uses this data to evaluate the accuracy vortex/wake-encounter models. The accuracy of these models has not before been evaluated using experimental data. The research results also presented the first analysis of the forces and moments imparted on an airplane during a wake vortex encounter using actual flight test data.

  18. Boundary-Dependent Chaotic Regions for a Bose-Einstein Condensate Interacting with Laser Field

    Institute of Scientific and Technical Information of China (English)

    ZHU Qian-Quan; HAI Wen-Hua; DENG Hai-Ming

    2007-01-01

    Spatial chaos of a Bose-Einstein condensate perturbed by a weak laser standing wave and a weak laser S pulse is studied. By using the perturbed chaotic solution we investigate the new type of Melnikov chaotic regions, which depend on an integration constant CQ determined by the boundary conditions. It is shown that when the |c0| values are small, the chaotic region corresponds to small values of laser wave vector k, and the chaotic region for the larger k values is related to the large |c0| values. The result is confirmed numerically by finding the chaotic and regular orbits on the Poincaré section for the two different parameter regions. Thus, for a fixed c0 the adjustment of k from a small value to large value can transform the chaotic region into the regular one or on the contrary, which suggests a feasible method for eliminating or generating Melnikov chaos.

  19. Levy Flights of Binary Orbits due to Impulsive Encounters

    CERN Document Server

    Collins, Benjamin F

    2008-01-01

    We examine the evolution of an almost circular Keplerian orbit interacting with unbound perturbers. We calculate the change in eccentricity and angular momentum that results from a single encounter, assuming the timescale for the interaction is shorter than the orbital period. The orbital perturbations are incorporated into a Boltzmann equation that allows for eccentricity dissipation. We present an analytic solution to the Boltzmann equation that describes the distribution of orbital eccentricity and relative inclination as a function of time. The eccentricity and inclination of the binary do not evolve according to a normal random walk but perform a Levy flight. The slope of the mass spectrum of perturbers dictates whether close gravitational scatterings are more important than distant tidal ones. When close scatterings are important, the mass spectrum sets the slope of the eccentricity and inclination distribution functions. We use this general framework to understand the eccentricities of several Kuiper b...

  20. Herpesviruses and Intermediate Filaments: Close Encounters with the Third Type

    Directory of Open Access Journals (Sweden)

    Laura Hertel

    2011-07-01

    Full Text Available Intermediate filaments (IF are essential to maintain cellular and nuclear integrity and shape, to manage organelle distribution and motility, to control the trafficking and pH of intracellular vesicles, to prevent stress-induced cell death, and to support the correct distribution of specific proteins. Because of this, IF are likely to be targeted by a variety of pathogens, and may act in favor or against infection progress. As many IF functions remain to be identified, however, little is currently known about these interactions. Herpesviruses can infect a wide variety of cell types, and are thus bound to encounter the different types of IF expressed in each tissue. The analysis of these interrelationships can yield precious insights into how IF proteins work, and into how viruses have evolved to exploit these functions. These interactions, either known or potential, will be the focus of this review.

  1. DIFFRACTION, REFRACTION, AND REFLECTION OF AN EXTREME-ULTRAVIOLET WAVE OBSERVED DURING ITS INTERACTIONS WITH REMOTE ACTIVE REGIONS

    Energy Technology Data Exchange (ETDEWEB)

    Shen Yuandeng; Liu Yu; Zhao Ruijuan; Tian Zhanjun [Yunnan Astronomical Observatory, Chinese Academy of Sciences, Kunming 650011 (China); Su Jiangtao [Key Laboratory of Solar Activity, Chinese Academy of Sciences, Beijing 100012 (China); Li Hui [Key Laboratory of Dark Matter and Space Astronomy, Chinese Academy of Sciences, Nanjing 210008 (China); Ichimoto, Kiyoshi; Shibata, Kazunari, E-mail: ydshen@ynao.ac.cn [Kwasan and Hida Observatories, Kyoto University, Kyoto 6078471 (Japan)

    2013-08-20

    We present observations of the diffraction, refraction, and reflection of a global extreme-ultraviolet (EUV) wave propagating in the solar corona. These intriguing phenomena are observed when the wave interacts with two remote active regions, and together they exhibit properties of an EUV wave. When the wave approached AR11465, it became weaker and finally disappeared in the active region, but a few minutes later a new wavefront appeared behind the active region, and it was not concentric with the incoming wave. In addition, a reflected wave was also simultaneously observed on the wave incoming side. When the wave approached AR11459, it transmitted through the active region directly and without reflection. The formation of the new wavefront and the transmission could be explained with diffraction and refraction effects, respectively. We propose that the different behaviors observed during the interactions may be caused by different speed gradients at the boundaries of the two active regions. We find that the EUV wave formed ahead of a group of expanding loops a few minutes after the start of the loops' expansion, which represents the initiation of the associated coronal mass ejection (CME). Based on these results, we conclude that the EUV wave should be a nonlinear magnetosonic wave or shock driven by the associated CME, which propagated faster than the ambient fast mode speed and gradually slowed down to an ordinary linear wave. Our observations support the hybrid model that includes both fast wave and slow non-wave components.

  2. Wind interactions above accretion discs: a model for broad-line regions and collimated outflow

    Energy Technology Data Exchange (ETDEWEB)

    Smith, M.D.; Raine, D.J. (Leicester Univ. (UK). Dept. of Astronomy)

    1985-01-15

    The interaction of a wind from an active galactic nucleus with a Compton-heating-induced wind from an accretion disc is studied. The nuclear wind is taken as initially supersonic and spherically symmetric. The disc wind arises when the disc surface is exposed to a hard and powerful X-ray source. Three classes of interaction are identified in terms of the relation between the pressure on the disc surface and the corresponding thermal and ram pressures in the nuclear wind.

  3. «Cross-border Environmental Peace» as the Interaction of Regional Norms and Local Power: Lessons from Cross-Regional Analysis of Water Security Debates

    Directory of Open Access Journals (Sweden)

    Harlan Koff

    2017-01-01

    Full Text Available This article contends that notions of «peace» and «justice» in cross-border water management vary in different world regions. Moreover, it argues that «peace» and «justice» can be explained by analyzing the interaction between «regional» interpretations and implementation of water security norms and local cross-border power structures. «Regional water security» is defined as the normative commitment to provide necessary water resources to communities within world regions. «Power,» which is defined traditionally as «the ability of actors to obtain their objectives despite opposition» is viewed as a function of political entrepreneurialism and opportunity structures. This article derives from a review of the pertinent literatures on «water security» and «water justice,» the two elements of «water peace» as well as scholarship on cross-border water management in different world regions. It discusses water governance within the framework of cross-border politics and comparative regional integration. It also includes analysis of the policy documents and websites of seventeen regional organizations as well as interviews with key actors and local experts on water management in specific cross-border case studies. The article is divided into five sections. Following this introduction, part two examines «water security» and «water justice» in international affairs. Part III then discusses «power» in cross-border water governance debates and addresses the transnational face of water security discussions. Part IV presents a comparative examination of cross-border «water justice» in selected world regions which is followed by theoretical considerations that are addressed in part V, the conclusion. In general, the article emphasizes the need to promote comparative cross-regional research on cross-border water governance in order to examine how «peace,» «security» and «justice» are framed in debates over water resources. 

  4. Binding characteristics and interactive region of 2-phenylpyrazolo[1,5-c]quinazoline with DNA.

    Science.gov (United States)

    Song, Yonghai; Zhong, Dandan; Luo, Jinhui; Tan, Hongliang; Chen, Shouhui; Li, Ping; Wang, Li; Wang, Tao

    2014-12-01

    The interaction between 2-phenylpyrazolo[1,5-c]quinazoline (PQ) and DNA under physiological conditions was investigated using multi-spectroscopic techniques, atomic force microscopy and gel electrophoresis. The thermodynamic parameters were estimated and were discussed in detail. The results of fluorescence-quenching experiments indicated that the main interactive force between PQ and DNA was a hydrophobic interaction and that it was a static quenching process. Potassium iodide and single-strand (ss)DNA quenching studies, together with circular dichroism spectra implied groove binding of PQ with DNA. Atomic force microscopy and gel electrophoresis experiments suggested that there were no major conformational changes in DNA upon interaction with PQ. In addition, UV/vis absorption titration of DNA bases confirmed that PQ bound with DNA mainly through a minor groove interaction and preferentially interacted with adenine and thymine. We anticipate that this work will provide useful information for the application of quinazoline derivatives in the fields of medicinal and pharmaceutical chemistry.

  5. Understanding the Pluto-Charon Plasma Environment during the New Horizons Encounter

    Science.gov (United States)

    Hale, J. M.; Paty, C. S.

    2016-12-01

    This work studies the plasma environment of the Pluto-Charon system during the New Horizons encounter using a multifluid MHD model. We have simulated scenarios in which the upstream solar wind conditions match those observed by New Horizons at the time of the encounter as well as cases which represent what are thought to be more typical, lower solar wind density, conditions. Simulations have also been conducted in which Charon possesses a trace ionosphere in an effort to explain a measured increase in ion density while New Horizons was within Charon's geometric shadow [McComas et al, 2016]. In order to more accurately reflect the local plasma environment, photochemistry and plasma-neutral interactions - specifically photoionization and electron impact ionization as plasma sources and charge exchange as a momentum loss mechanism - have been incorporated into the model. Given the unexpectedly small interaction region observed by New Horizons and the corresponding compactness of Pluto's atmosphere, the heightened physical accuracy afforded by these additions to the model is necessary so that a useful modeling context for the brief period of available physical data may be provided. Our previous work in which Charon is placed either directly upstream or directly downstream of Pluto has been expanded in light of the previously mentioned data returned by New Horizons. The results of this study demonstrate that in these circumstances Charon modifies the upstream flow, both in the case in which Charon possesses an ionosphere, and in the case in which Charon is without an ionosphere. The case in which Charon is upstream and has an ionosphere results in a notable decrease in ionospheric loss from Pluto due to a shielding effect.

  6. Challenges And Concepts for Design of An Interaction Region With Push-Pull Arrangement of Detectors - An Interface Document

    Energy Technology Data Exchange (ETDEWEB)

    Parker, B.; /Brookhaven; Herve, Alain; Osborne, J.; /CERN; Mikhailichenko, A.; /Cornell U., Phys. Dept.; Buesser, K.; /DESY; Ashmanskas, B.; Kuchler, Victor P.; Mokhov, N.; /Fermilab; Enomoto, A.; Sugimoto, Y.; Tauchi, T.; Tsuchiya, K.; /KEK, Tsukuba; Weisend, J.; /NSF, Wash., D.C.; Burrows, P.; /Oxford U.; Markiewicz, Thomas W.; Oriunno, M.; Seryi, Andrei; Sullivan, M.; /SLAC; Angal-Kalinin, D.; /Rutherford; Sanuki, T.; Yamamoto, H.; /Tohoku U.

    2011-10-14

    Two experimental detectors working in a push-pull mode has been considered for the Interaction Region of the International Linear Collider. The push-pull mode of operation sets specific requirements and challenges for many systems of detector and machine, in particular for the IR magnets, for the cryogenics and alignment system, for beamline shielding, for detector design and overall integration, and so on. These challenges and the identified conceptual solutions discussed in the paper intend to form a draft of the Interface Document which will be developed further in the nearest future. The authors of the present paper include the organizers and conveners of working groups of the workshop on engineering design of interaction region IRENG07, the leaders of the IR Integration within Global Design Effort Beam Delivery System, and the representatives from each detector concept submitting the Letters Of Intent.

  7. Comparison of the effective interaction to various orders in different mass regions

    CERN Document Server

    Hjorth-Jensen, M; Polls, A; Osnes, E

    1995-01-01

    The convergence of the perturbation expansion for the effective interaction to be used in shell-model calculations is investigated as function of the mass number A, from A=4 to A=208. As the mass number increases, there are more intermediate states to sum over in each higher-order diagram which contributes to the effective interaction. Together with the fact that the energy denominators in each diagram are smaller for larger mass numbers, these two effects could largely enhance higher-order contributions to the effective interaction, thereby deteriorating the order-by-order convergence of the effective interaction. This effect is counterbalanced by the short range of the nucleon-nucleon interaction, which implies that its matrix elements are weaker for valence single-particle states in ``large'' nuclei with large mass number as compared to those in light nuclei. These effects are examined by comparing various mean values of the matrix elements. It turns out that the contributions from higher-order terms remai...

  8. Interaction Effects between Cellulose and Water in Nanocrystalline and Amorphous Regions: A Novel Approach Using Molecular Modeling

    Directory of Open Access Journals (Sweden)

    Ali Chami Khazraji

    2013-01-01

    Full Text Available The hydrophilic/hydrophobic nature of cellulose is based on its structural anisotropy. Cellulose chains are arranged in a parallel manner and are organized in sheets stabilized by interchain OH–O hydrogen bonds, whereas the stacking of sheets is stabilized by both van der Waals (vdW dispersion forces and weak CH–O hydrogen bonds. Cellulose has a strong affinity to itself and materials containing hydroxyls, especially water. Based on the preponderance of hydroxyl functional groups, cellulose polymer is very reactive with water. Water molecular smallness promotes the reaction with the cellulose chains and immediately formed hydrogen bonds. Besides that, vdW dispersion forces play an important role between these two reactive entities. They stabilize the cellulose structure according to the considerable cohesive energy in the cellulose network. Hydrogen bonding, electrostatic interactions, and vdW dispersion forces play an important role in determining the cellulose crystal structure during the cellulose-water interactions. As a result of these interactions, the volume of cellulose undergoes a meaningful change expressed not only by an exponential growth in amorphous regions, but also by an expansion in nanocrystalline regions. In addition, the volume change is associated with the swelling material expressed as a weight gain of the cellulose polymer. Molecular modeling using Accelrys Materials Studio allowed us to open a new horizon and is helpful for understanding cellulose-water interactions.

  9. Tight junction protein Par6 interacts with an evolutionarily conserved region in the amino terminus of PALS1/stardust.

    Science.gov (United States)

    Wang, Qian; Hurd, Toby W; Margolis, Ben

    2004-07-16

    Tight junctions are the structures in mammalian epithelial cells that separate the apical and basolateral membranes and may also be important in the establishment of cell polarity. Two evolutionarily conserved multiprotein complexes, Crumbs-PALS1 (Stardust)-PATJ and Cdc42-Par6-Par3-atypical protein kinase C, have been implicated in the assembly of tight junctions and in polarization of Drosophila melanogaster epithelia. These two complexes have been linked physically and functionally by an interaction between PALS1 and Par6. Here we identify an evolutionarily conserved region in the amino terminus of PALS1 as the Par6 binding site and identify valine and aspartic acid residues in this region as essential for interacting with the PDZ domain of Par6. We have also characterized, in more detail, the amino terminus of Drosophila Stardust and demonstrate that the interaction mechanism between Stardust and Drosophila Par6 is evolutionarily conserved. Par6 interferes with PATJ in binding PALS1, and these two interactions do not appear to function synergistically. Taken together, these results define the molecular mechanisms linking two conserved polarity complexes.

  10. Spatial Interaction Modelling of Cross-Region R&D Collaborations: Empirical Evidence from the 5th EU Framework Programme

    CERN Document Server

    Scherngell, Thomas; 10.1111/j.1435-5957.2008.00215.x

    2010-01-01

    The last few years have witnessed an increasing interest in the geography of innovation. As noted by Autant-Bernard et al. (2007a), the geographical dimension of innovation deserves further attention by analysing such phenomena as R&D collaborations. In this study we focus on cross-region R&D collaborations in Europe. The European coverage is achieved by using data on collaborative R&D projects funded by the EU Framework Programmes (FPs) between organisation that are located in 255 NUTS-2 regions of the 25 pre-2007 EU member-states, as well as Norway and Switzerland. The objective is to identify separation effects - such as geographical or technological effects - on the constitution of cross-region collaborative R&D activities. We specify a Poisson spatial interaction model to analyse these questions. The dependent variable is the intensity of cross-region R&D collaborations, the independent variables include origin, destination and separation characteristics of interaction. The results pr...

  11. Comparative internal kinematics of the HII regions in interacting and isolated galaxies: implications for massive star formation modes

    CERN Document Server

    Zaragoza-Cardiel, Javier; Font, Joan; García-Lorenzo, Begoña; Camps-Fariña, Artemi; Fathi, Kambiz; James, Philip A; Erroz-Ferrer, Santiago; Barrera-Ballesteros, Jorge; Cisternas, Mauricio

    2015-01-01

    We have observed 10 interacting galaxy pairs using the Fabry-Perot interferometer GH$\\alpha$FaS (Galaxy H$\\alpha$ Fabry-Perot system) on the $4.2\\rm{m}$ William Herschel Telescope (WHT) at the Observatorio del Roque de los Muchachos, La Palma. We present here the H$\\alpha$ surface brightness, velocity and velocity dispersion maps for the 10 systems we have not previously observed using this technique, as well as the physical properties (sizes, H$\\alpha$ luminosities and velocity dispersion) of 1259 HII regions from the full sample. We also derive the physical properties of 1054 HII regions in a sample of 28 isolated galaxies observed with the same instrument in order to compare the two populations of HII regions. We find a population of the brightest HII regions for which the scaling relations, for example the relation between the H$\\alpha$ luminosity and the radius, are clearly distinct from the relations for the regions of lower luminosity. The regions in this bright population are more frequent in the inte...

  12. Interactive lakes in the Canadian Regional Climate Model, version 5: the role of lakes in the regional climate of North America

    Directory of Open Access Journals (Sweden)

    Bernard Dugas

    2012-02-01

    Full Text Available Two one-dimensional (1-D column lake models have been coupled interactively with a developmental version of the Canadian Regional Climate Model. Multidecadal reanalyses-driven simulations with and without lakes revealed the systematic biases of the model and the impact of lakes on the simulated North American climate.The presence of lakes strongly influences the climate of the lake-rich region of the Canadian Shield. Due to their large thermal inertia, lakes act to dampen the diurnal and seasonal cycle of low-level air temperature. In late autumn and winter, ice-free lakes induce large sensible and latent heat fluxes, resulting in a strong enhancement of precipitation downstream of the Laurentian Great Lakes, which is referred to as the snow belt.The FLake (FL and Hostetler (HL lake models perform adequately for small subgrid-scale lakes and for large resolved lakes with shallow depth, located in temperate or warm climatic regions. Both lake models exhibit specific strengths and weaknesses. For example, HL simulates too rapid spring warming and too warm surface temperature, especially in large and deep lakes; FL tends to damp the diurnal cycle of surface temperature. An adaptation of 1-D lake models might be required for an adequate simulation of large and deep lakes.

  13. Asymmetric multisensory interactions of visual and somatosensory responses in a region of the rat parietal cortex.

    Directory of Open Access Journals (Sweden)

    Michael T Lippert

    Full Text Available Perception greatly benefits from integrating multiple sensory cues into a unified percept. To study the neural mechanisms of sensory integration, model systems are required that allow the simultaneous assessment of activity and the use of techniques to affect individual neural processes in behaving animals. While rodents qualify for these requirements, little is known about multisensory integration and areas involved for this purpose in the rodent. Using optical imaging combined with laminar electrophysiological recordings, the rat parietal cortex was identified as an area where visual and somatosensory inputs converge and interact. Our results reveal similar response patterns to visual and somatosensory stimuli at the level of current source density (CSD responses and multi-unit responses within a strip in parietal cortex. Surprisingly, a selective asymmetry was observed in multisensory interactions: when the somatosensory response preceded the visual response, supra-linear summation of CSD was observed, but the reverse stimulus order resulted in sub-linear effects in the CSD. This asymmetry was not present in multi-unit activity however, which showed consistently sub-linear interactions. These interactions were restricted to a specific temporal window, and pharmacological tests revealed significant local intra-cortical contributions to this phenomenon. Our results highlight the rodent parietal cortex as a system to model the neural underpinnings of multisensory processing in behaving animals and at the cellular level.

  14. Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo

    NARCIS (Netherlands)

    Shabani, D.; Tahiri, Z.; Bara, P.; Hudhra, K.; Malaj, L.; Jucja, B.; Bozalia, A.; Burazeri, G.

    2014-01-01

    AIM: Our aim was to assess the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the adult population of transitional Kosovo. METHODS: A cross-sectional study was conducted including a representative sample of 1921 patients aged >/=18 years (mean age: 57.8+/-11.2 y

  15. Prevalence and Correlates of Drug-drug Interactions in the Regional Hospital of Gjilan, Kosovo

    NARCIS (Netherlands)

    Shabani, D.; Tahiri, Z.; Bara, P.; Hudhra, K.; Malaj, L.; Jucja, B.; Bozalia, A.; Burazeri, G.

    2014-01-01

    AIM: Our aim was to assess the prevalence and socioeconomic and clinical correlates of drug-drug interactions among the adult population of transitional Kosovo. METHODS: A cross-sectional study was conducted including a representative sample of 1921 patients aged >/=18 years (mean age: 57.8+/-11.2

  16. Does serotonin influence aggression? Comparing regional activity before and during social interaction

    DEFF Research Database (Denmark)

    Summers, C.H.; Korzan, W.J.; Lukkes, J.L.

    2005-01-01

    Serotonin is widely believed to exert inhibitory control over aggressive behavior and intent. In addition, a number of studies of fish, reptiles, and mammals, including the lizard Anolis carolinensis, have demonstrated that serotonergic activity is stimulated by aggressive social interaction in b...

  17. Rhinoplasty Education Using a Standardized Patient Encounter

    Science.gov (United States)

    Wright, Eric J.; Khosla, Rohit K.; Howell, Lori

    2016-01-01

    Background Comprehensive aesthetic surgery training continues to be a challenge for residency programs. Our residency program developed a rhinoplasty-based objective structured clinical examination (OSCE) based upon validated methods as part of the residency education curriculum. We report our experience with the rhinoplasty-based OSCE and offer guidance to its incorporation within residency programs. Methods The encounter involved resident evaluation and operative planning for a standardized patient desiring a rhinoplasty procedure. Validated OSCE methods currently used at our medical school were implemented. Residents were evaluated on appropriate history taking, physical examination, and explanation to the patient of treatment options. Examination results were evaluated using analysis of variance (statistical significance POSCE. Medical knowledge assessment showed increasing performance with clinical year, 50% versus 84% for postgraduate year 3 and 6, respectively (POSCE realistically represents an actual patient encounter. All faculty confirmed the utility of evaluating resident performance during the OSCE as a useful assessment tool for determining the Next Accreditation System Milestone level. Conclusions Aesthetic surgery training for residents will require innovative methods for education. Our examination showed a program-educational weakness in billing/coding, an area that will be improved upon by topic-specific lectures. A thoroughly developed OSCE can provide a realistic educational opportunity to improve residents' performance on the nonoperative aspects of rhinoplasty and should be considered as an adjunct to resident education. PMID:27689053

  18. Envisioning invertebrates and other aquatic encounters

    Science.gov (United States)

    Hayward, Eva

    2007-12-01

    To "envision" animals is to visualize, to experience, to figure, to image, kinds of species, discourses, representations, institutions, histories, epistemologies; and, to "imagine possible" a set of material and ethical relationships between species. This dissertation explores the "envisioning of animals" that takes place through/across/between the interfaces of seawater/visuality/experience/biology/technology/phyla---as illustrated in the documentary works of Jean Painleve (scientist and filmmaker), Genevieve Hamon (filmmaker and set-designer), Leni Riefenstahl (filmmaker and photographer), and David Powell (scientist and aquarist). In each case, aesthetic conceptions of beauty and/or ambiguity coupled with biological epistemology and phenomenology of the organisms themselves compete over "what gets to count as culture and nature," and in doing so, construct a host of hybridized and enmeshed "encounters." In the process the following questions are raised: What is the role of the ocean---it's ecosystems and semiotics---in the production of "envisioning"? How are animals used---and in turn shape and reshape the users---to construct tropes of encounter? What theories can be used to understand the phenomenological, semiotic, material, and rhetorical use/miss-use of animals in the articulation of history, economy, biology, narrativity, and representation? How does this motley crew of documentarians answer differently "the animal question," and challenge and/or reinforce anthropocentrism? Divided into two parts, the dissertation first develops a set of methodological questions derived from critical appraisal of "envisioning," encountering, and embodying through science studies, as well as an account of the use and misuse of animals as only "stand ins" for human intentionality; secondly, the dissertation analyses the work of the documentarians in question. Jean Painleve and Genevieve Hamon are shown to critique traditions of representation in nature/science films

  19. Excitation of the orbital inclination of Iapetus during planetary encounters

    Energy Technology Data Exchange (ETDEWEB)

    Nesvorný, David; Vokrouhlický, David; Deienno, Rogerio; Walsh, Kevin J., E-mail: davidn@boulder.swri.edu [Department of Space Studies, Southwest Research Institute, 1050 Walnut Street, Suite 300, Boulder, CO 80302 (United States)

    2014-09-01

    Saturn's moon, Iapetus, has an orbit in a transition region where the Laplace surface is bending from the equator to the orbital plane of Saturn. The orbital inclination of Iapetus to the local Laplace plane is ≅ 8°, which is unexpected because the inclination should be ≅ 0 if Iapetus formed from a circumplanetary disk on the Laplace surface. It thus appears that some process has pumped up Iapetus's inclination while leaving its eccentricity near zero (e ≅ 0.03 at present). Here, we examined the possibility that Iapetus's inclination was excited during the early solar system instability when encounters between Saturn and ice giants occurred. We found that the dynamical effects of planetary encounters on Iapetus's orbit sensitively depend on the distance of the few closest encounters. In 4 out of 10 instability cases studied here, the orbital perturbations were too large to be plausible. In one case, Iapetus's orbit was practically unaffected. In the remaining five cases, the perturbations of Iapetus's inclination were adequate to explain its present value. In three of these cases, however, Iapetus's eccentricity was excited to >0.1-0.25, and it is not clear whether it could have been damped to its present value (≅ 0.03) by a subsequent process (e.g., tides and dynamical friction from captured irregular satellites do not seem to be strong enough). Our results therefore imply that only 2 out of 10 instability cases (∼20%) can excite Iapetus's inclination to its current value (∼30% of trials lead to >5°) while leaving its orbital eccentricity low.

  20. Co-creation of Innovations in ICT based service encounters

    DEFF Research Database (Denmark)

    Sørensen, Jannick Kirk; Henten, Anders

    2014-01-01

    Innovations in services often emanate from service encounters (i.e. the touch points between the service producers and the customers). Two different types of service encounters are dealt with: face-to-face and ICT-based service encounters. The aim of the chapter is to examine the specific...... conditions for innovations from ICT-based service encounters. The service encounter research tradition is mostly concerned with customer satisfaction. The perspective of the present chapter is on innovations in the service encounter. The specific contribution of the chapter is to establish a conceptual...

  1. Interactions between traditional regional determinants and socio-economic status on dietary patterns in a sample of French men.

    Science.gov (United States)

    Perrin, Anne-Elisabeth; Dallongeville, Jean; Ducimetière, Pierre; Ruidavets, Jean-Bernard; Schlienger, Jean-Louis; Arveiler, Dominique; Simon, Chantal

    2005-01-01

    The aim of the present study was to assess the respective contributions of regional and socio-economic factors to dietary pattern. We used the data from the final MONICA (MONItoring of trends and determinants in Cardiovascular disease) population survey conducted in the three French centres in 1995-7 among a representative sample of 976 men aged 45-64 years. Dietary intake was assessed using a 3-d record method. Dietary patterns were identified by a factor analysis, based on fifteen food items. An analysis of variance was then used to study their relationship with regional and socio-economic determinants. Two major dietary patterns were identified: a 'Western diet', characterized by high intakes of sugar and sweets, grains, butter, added fats, eggs, potatoes and cheese; a 'prudent diet', mainly distinguished by high intakes of fruit, vegetables, olive oil and fish and low intakes of alcohol, high-fat meat and potatoes. Strong associations were mostly observed with the 'prudent diet' pattern, with a significant relationship with region, educational and income-tax levels, leisure-time physical activity and smoking status. There was also a statistically significant interaction between region and educational level (P=0.05), and between region and income-tax level (P=0.03), indicating that the influence of socio-economic factors is different among regions. In conclusion, these results indicate large regional and socio-economic differences in the dietary patterns of this French male population. When considering the 'prudent diet' pattern, they also suggest that traditional regional influences may now be overcome by socio-economic determinants.

  2. Modeling land-surface processes and land-atmosphere interactions in the community weather and regional climate WRF model (Invited)

    Science.gov (United States)

    Chen, F.; Barlage, M. J.

    2013-12-01

    The Weather Research and Forecasting (WRF) model has been widely used with high-resolution configuration in the weather and regional climate communities, and hence demands its land-surface models to treat not only fast-response processes, such as plant evapotranspiration that are important for numerical weather prediction but also slow-evolving processes such as snow hydrology and interactions between surface soil water and deep aquifer. Correctly representing urbanization, which has been traditionally ignored in coarse-resolution modeling, is critical for applying WRF to air quality and public health research. To meet these demands, numerous efforts have been undertaken to improve land-surface models (LSM) in WRF, including the recent implementation of the Noah-MP (Noah Multiple-Physics). Noah-MP uses multiple options for key sub-grid land-atmosphere interaction processes (Niu et al., 2011; Yang et al., 2011), and contains a separate vegetation canopy representing within- and under-canopy radiation and turbulent processes, a multilayer physically-based snow model, and a photosynthesis canopy resistance parameterization with a dynamic vegetation model. This paper will focus on the interactions between fast and slow land processes through: 1) a benchmarking of the Noah-MP performance, in comparison to five widely-used land-surface models, in simulating and diagnosing snow evolution for complex terrain forested regions, and 2) the effects of interactions between shallow and deep aquifers on regional weather and climate. Moreover, we will provide an overview of recent improvements of the integrated WRF-Urban modeling system, especially its hydrological enhancements that takes into account the effects of lawn irrigation, urban oasis, evaporation from pavements, anthropogenic moisture sources, and a green-roof parameterization.

  3. Interacting Regional-Scale Regime Shifts for Biodiversity and Ecosystem Services

    NARCIS (Netherlands)

    Leadley, P.; Proenca, V.; Fernandez-Manjarres, J.; Pereira, H.M.; Alkemade, J.R.M.; Biggs, R.; Bruley, E.; Cheung, W.; Cooper, D.; Figueiredo, J.; Gilman, E.; Guenette, S.; Hurtt, G.; Mbow, C.; Oberdorff, T.; Revenga, C.; Scharlemann, J.P.W.; Scholes, R.; Smith, M.S.; Sumaila, U.R.; Walpole, M.

    2014-01-01

    Current trajectories of global change may lead to regime shifts at regional scales, driving coupled human-environment systems to highly degraded states in terms of biodiversity, ecosystem services, and human well-being. For business-as-usual socioeconomic development pathways, regime shifts are proj

  4. Regional septal hinge-point injury contributes to adverse biventricular interactions in pulmonary hypertension

    DEFF Research Database (Denmark)

    Nielsen, Eva Amalie; Okumura, Kenichi; Sun, Mei

    2017-01-01

    chronic RV pressure overload. Two distinct animal models were studied: A rabbit model of increased RV pressure-load through progressive pulmonary artery banding A rat model of monocrotaline (MCT)-induced pulmonary arterial hypertension (PAH). Regional myocardial function was assessed by speckle-tracking...

  5. Tropical-temperate interactions over southern Africa simulated by a regional climate model

    Energy Technology Data Exchange (ETDEWEB)

    Vigaud, N.; Pohl, B.; Cretat, J. [UMR 6282 Biogeosciences CNRS/Universite de Bourgogne, Centre de Recherches de Climatologie, Dijon (France)

    2012-12-15

    The Weather Research and Forecasting model (WRF) forced by ERA40 re-analyses, is used to examine, at regional scale, the role of key features of the local atmospheric circulation on the origin and development of Tropical Temperate Troughs (TTTs) representing a major contribution to South African rainfall during austral summer. A cluster analysis applied on 1971-2000 ERA40 and WRF simulated daily outgoing longwave radiation reveals for the November-February season three coherent regimes characteristic of TTTs over the region. Analyses of WRF simulated TTTs suggest that their occurrence is primarily linked with mid-latitude westerly waves and their phasing. Ensemble experiments designed for the case of austral summer 1996/1997 allow to examine the reproducibility of TTT events. The results obtained illustrate the importance of westerly waves phasing regarding the persistence of rain-producing continental TTT events. Moreover, oceanic surface conditions prevailing over the Agulhas current regions of the South West Indian Ocean (SWIO) are also found to influence TTT persistence for regional experiments with an oceanic mixed layer, warmer sea surface temperatures being associated with increased moisture advection from the SWIO where latent heat release is enhanced, favoring baroclinic instability and thus sustaining convection activity locally. (orig.)

  6. Interacting Regional-Scale Regime Shifts for Biodiversity and Ecosystem Services

    NARCIS (Netherlands)

    Leadley, P.; Proenca, V.; Fernandez-Manjarres, J.; Pereira, H.M.; Alkemade, J.R.M.; Biggs, R.; Bruley, E.; Cheung, W.; Cooper, D.; Figueiredo, J.; Gilman, E.; Guenette, S.; Hurtt, G.; Mbow, C.; Oberdorff, T.; Revenga, C.; Scharlemann, J.P.W.; Scholes, R.; Smith, M.S.; Sumaila, U.R.; Walpole, M.

    2014-01-01

    Current trajectories of global change may lead to regime shifts at regional scales, driving coupled human-environment systems to highly degraded states in terms of biodiversity, ecosystem services, and human well-being. For business-as-usual socioeconomic development pathways, regime shifts are proj

  7. Quasar Evolution Driven by Galaxy Encounters in Hierarchical Structures

    CERN Document Server

    Menci, N; Fontana, A; Giallongo, E; Poli, F; Vittorini, V

    2003-01-01

    We link the evolution of the galaxies in the hierarchical clustering scenario with the changing accretion rates of cold gas onto the central massive black holes that power the quasars. We base on galaxy interactions as main triggers of accretion; the related scaling laws are taken up from Cavaliere & Vittorini (2000), and grafted to a semi-analytic code for galaxy formation. As a result, at high $z$ the protogalaxies grow rapidly by hierarchical merging; meanwhile, much fresh gas is imported and also destabilized, so the holes are fueled at their full Eddington rates. At lower $z$ the galactic dynamical events are mostly encounters in hierarchically growing groups; now the refueling peters out, as the residual gas is exhausted while the destabilizing encounters dwindle. So, with no parameter tuning other than needed for stellar observables, our model uniquely produces at $z>3$ a rise, and at $z\\lesssim 2.5 $ a decline of the bright quasar population as steep as observed. In addition, our results closely f...

  8. Cross-talk studies between FCC-hh Experimental Interaction Regions

    CERN Document Server

    Abelleira, Jose; Appleby, Robert Barrie; Rafique, Haroon; Besana, Maria Ilaria

    2017-01-01

    Debris from 50 TeV proton-proton collisions at the main interaction point in the FCC-hh may contribute to the background in the subsequent detector. This cross-talk is of possible concern for the FCC-hh due to the high luminosity and energy of the collider. DPMJET-III is used as a collision debris generator in order to assess the muon cross-talk contribution. An analytical calculation of muon range in rock is performed. This is followed by a full Monte Carlo simulation using FLUKA, where the accelerator tunnel has been modelled. The muon cross talk between the adjacent interaction points is assessed and its implications for FCC-hh design are discussed.

  9. Modeling the Surface Water-Groundwater Interaction in Arid and Semi-Arid Regions Impacted by Agricultural Activities

    Science.gov (United States)

    Tian, Y.; Wu, B.; Zheng, Y.

    2013-12-01

    In many semi-arid and arid regions, interaction between surface water and groundwater plays an important role in the eco-hydrological system. The interaction is often complicated by agricultural activities such as surface water diversion, groundwater pumping, and irrigation. In existing surface water-groundwater integrated models, simulation of the interaction is often simplified, which could introduce significant simulation uncertainty under certain circumstance. In this study, GSFLOW, a USGS model coupling PRMS and MODFLOW, was improved to better characterize the surface water-groundwater interaction. The practices of water diversion from rivers, groundwater pumping and irrigation are explicitly simulated. In addition, the original kinematic wave routing method was replaced by a dynamic wave routing method. The improved model was then applied in Zhangye Basin (the midstream part of Heihe River Baisn), China, where the famous 'Silk Road' came through. It is a typical semi-arid region of the western China, with extensive agriculture in its oasis. The model was established and calibrated using the data in 2000-2008. A series of numerical experiments were conducted to evaluate the effect of those improvements. It has been demonstrated that with the improvements, the observed streamflow and groundwater level were better reproduced by the model. The improvements have a significant impact on the simulation of multiple fluxes associated with the interaction, such as groundwater discharge, riverbed seepage, infiltration, etc. Human activities were proved to be key elements of the water cycle in the study area. The study results have important implications to the water resources modeling and management in semi-arid and arid basins.

  10. Housing shortages in urban regions: aggressive interactions at tree hollows in forest remnants.

    Directory of Open Access Journals (Sweden)

    Adrian Davis

    Full Text Available Urbanisation typically results in a reduction of hollow-bearing trees and an increase in the density of particularly species, potentially resulting in an increased level of competition as cavity-nesting species compete for a limited resource. To improve understanding of hollow usage between urban cavity-nesting species in Australia, particularly parrots, we investigated how the hollow-using assemblage, visitation rate, diversity and number of interactions varied between hollows within urban remnant forest and continuous forest. Motion-activated video cameras were installed, via roped access to the canopy, and hollow usage was monitored at 61 hollows over a two-year period. Tree hollows within urban remnants had a significantly different assemblage of visitors to those in continuous forest as well as a higher rate of visitation than hollows within continuous forest, with the rainbow lorikeet making significantly more visitations than any other taxa. Hollows within urban remnants were characterised by significantly higher usage rates and significantly more aggressive interactions than hollows within continuous forest, with parrots responsible for almost all interactions. Within urban remnants, high rates of hollow visitation and both interspecific and intraspecific interactions observed at tree hollows suggest the number of available optimal hollows may be limiting. Understanding the usage of urban remnant hollows by wildlife, as well as the role of parrots as a potential flagship for the conservation of tree-hollows, is vital to prevent a decrease in the diversity of urban fauna, particularly as other less competitive species risk being outcompeted by abundant native species.

  11. Possibilities of creating meaningful encounters in anesthesia nursing

    DEFF Research Database (Denmark)

    Aagaard, Karin

    Anesthesia nursing is performed in a highly technological environment with restricted time for interaction with patients. Patients are in a vulnerable position, which can be characterized by anxiety regarding the anesthetic and surgical procedure. The bedrock of effective nursing care is to facil......Anesthesia nursing is performed in a highly technological environment with restricted time for interaction with patients. Patients are in a vulnerable position, which can be characterized by anxiety regarding the anesthetic and surgical procedure. The bedrock of effective nursing care...... of nursing. In this dissertation, focused ethnography is used to explore the interactions between patients and nurse anesthetists before general anesthesia. Moreover, it will explore the professional identity of nurse anesthetists, in relation to the situation of preparing patients for general anesthesia....... A micro-substantive theory is developed regarding the opportunities for creating meaningful encounters between patients and nurse anesthetists. The theory is based on three dominant motivations for interaction in anesthesia nursing. The context of care is not committed and responsive to the core elements...

  12. Impulsive behaviour in interpersonal encounters: associations with quarrelsomeness and agreeableness.

    Science.gov (United States)

    aan Het Rot, Marije; Moskowitz, D S; Young, Simon N

    2015-02-01

    Associations between impulsivity and interpersonal behaviours have rarely been examined, even though impulsivity may disrupt the flow of social interactions. For example, it is unknown to what extent the commonly used Barratt Impulsiveness Scale (BIS-11) predicts impulsive behaviour in social situations, and how behaving impulsively during interpersonal encounters might influence levels of quarrelsomeness and agreeableness. In this study, 48 healthy working individuals completed the BIS-11 and recorded their behaviour in social situations using event-contingent recording. Record forms included items representing quarrelsome, agreeable, and impulsive behaviours. BIS-11 motor impulsiveness scores predicted impulsive behaviour in social situations. Impulsive behaviour was associated, in different interactions, with both agreeableness and quarrelsomeness. Behaving impulsively in specific interactions was negatively associated with agreeableness in participants with higher BIS-11 motor impulsiveness and positively associated with agreeableness in participants with lower BIS-11 motor impulsiveness. Impulsive quarrelsome behaviour may cause interpersonal problems. Impulsive agreeable behaviour may have positive effects in individuals with low trait impulsivity. The idea that there are between-person differences in the effects of state impulsivity on the flow of social interaction deserves further study.

  13. Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions.

    Science.gov (United States)

    Akiba, Hiroki; Tsumoto, Kouhei

    2015-07-01

    Antibodies (immunoglobulins) bind specific molecules (i.e. antigens) with high affinity and specificity. In order to understand their mechanisms of recognition, interaction analysis based on thermodynamic and kinetic parameters, as well as structure determination is crucial. In this review, we focus on mutational analysis which gives information about the role of each amino acid residue in antibody-antigen interaction. Taking anti-hen egg lysozyme antibodies and several anti-small molecule antibodies, the energetic contribution of hot-spot and non-hot-spot residues is discussed in terms of thermodynamics. Here, thermodynamics of the contribution from aromatic, charged and hydrogen bond-forming amino acids are discussed, and their different characteristics have been elucidated. The information gives fundamental understanding of the antibody-antigen interaction. Furthermore, the consequences of antibody engineering are analysed from thermodynamic viewpoints: humanization to reduce immunogenicity and rational design to improve affinity. Amino acid residues outside hot-spots in the interface play important roles in these cases, and thus thermodynamic and kinetic parameters give much information about the antigen recognition. Thermodynamic analysis of mutant antibodies thus should lead to advanced strategies to design and select antibodies with high affinity.

  14. The International, Regional and Local Interaction in the Promotion of Cultural Tourism in Mozambique

    Directory of Open Access Journals (Sweden)

    Elisa Magnani

    2017-03-01

    Full Text Available This paper discusses the tourist promotion of the cultural and natural heritage in Mozambique, one of Africa’s poorest countries, whose strategy for the reduction of poverty highlights the role of tourism in supporting territorial development and implementing the Millennium/Sustainable Development Goals, the United Nation plan to end poverty, protect the planet and ensure prosperity for all. The country has produced a national strategy for the development of tourism that is based on the integration at the national level of international and regional policies implemented through the territorial action of several subjects working at the local level. Among them, regional and international Ngos, that play an important role in promoting actions aimed at capacity-building, advocacy, empowerment. This strategy makes of Mozambique a very interesting example of the rescaling process in tourism development that guides the political agenda of both the international tourist organizations and the national governments.

  15. Interaction of neutral atoms and plasma turbulence in the tokamak edge region

    OpenAIRE

    Wersal, Christoph; Ricci, Paolo; Jorge, Rogério; Morales, Jorge; Paruta, Paola; Riva, Fabio

    2016-01-01

    A novel first-principles self-consistent model that couples plasma and neutral atom physics suitable for the simulation of turbulent plasma behaviour in the tokamak edge region has been developed and implemented in the GBS code. While the plasma is modelled by the drift-reduced two fluid Braginskii equations, a kinetic model is used for the neutrals, valid in short and in long mean free path scenarios. The model includes ionization, charge-exchange, recombination, and elastic collisional proc...

  16. INTERACTIVE STUDY BETWEEN IDENTICAL COHERENT STRUCTURES IN THE WALL REGION OF A TURBULENT BOUNDARY LAYER

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A theoretical model for identical coherent structures in the wall region of a turbulent boundary layer was proposed, using the idea of general resonant triad of the hydrodynamic stability. The evolution of the structures in the wall region of a turbulent boundary layer was studied by combining the compact finite differences of high numerical accuracy and the Fourier spectral hybrid method for solving the three dimensional Navier-Stokes equations. In this method, the third order mixed explicit-implicit scheme was applied for the time integration. The fifth-order upwind compact finite difference schemes for the nonlinear convection terms in the physical space, and the sixth-order center compact schemes for the derivatives in spectral space were introduced, respectively. The fourth-order compact schemes satisfied by the velocities and pressure in spectral space was derived. As an application, the method was implemented to the wall region of a turbulent boundary to study the evolution of identical coherent structures. It is found that the numerical results are satisfactory.

  17. Encounter Probability of Individual Wave Height

    DEFF Research Database (Denmark)

    Liu, Z.; Burcharth, H. F.

    1998-01-01

    wave height corresponding to a certain exceedence probability within a structure lifetime (encounter probability), based on the statistical analysis of long-term extreme significant wave height. Then the design individual wave height is calculated as the expected maximum individual wave height...... associated with the design significant wave height, with the assumption that the individual wave heights follow the Rayleigh distribution. However, the exceedence probability of such a design individual wave height within the structure lifetime is unknown. The paper presents a method for the determination...... of the design individual wave height corresponding to an exceedence probability within the structure lifetime, given the long-term extreme significant wave height. The method can also be applied for estimation of the number of relatively large waves for fatigue analysis of constructions....

  18. Spider behaviors include oral sexual encounters

    Science.gov (United States)

    Gregorič, Matjaž; Šuen, Klavdija; Cheng, Ren-Chung; Kralj-Fišer, Simona; Kuntner, Matjaž

    2016-01-01

    Several clades of spiders whose females evolved giant sizes are known for extreme sexual behaviors such as sexual cannibalism, opportunistic mating, mate-binding, genital mutilation, plugging, and emasculation. However, these behaviors have only been tested in a handful of size dimorphic spiders. Here, we bring another lineage into the picture by reporting on sexual behavior of Darwin’s bark spider, Caerostris darwini. This sexually size dimorphic Madagascan species is known for extreme web gigantism and for producing the world’s toughest biomaterial. Our field and laboratory study uncovers a rich sexual repertoire that predictably involves cannibalism, genital mutilation, male preference for teneral females, and emasculation. Surprisingly, C. darwini males engage in oral sexual encounters, rarely reported outside mammals. Irrespective of female’s age or mating status males salivate onto female genitalia pre-, during, and post-copulation. While its adaptive significance is elusive, oral sexual contact in spiders may signal male quality or reduce sperm competition. PMID:27126507

  19. Ethics in the bank internet encounter

    DEFF Research Database (Denmark)

    Rendtorff, Jacob Dahl; Mattsson, Jan

    2012-01-01

    /implications – The important implication for managerial research of this study would be for banks to focus on customer competency with an ethical concern instead of only being concerned with technical solutions for effective internet operations. Practical implications – Since more and more businesses are digitally based......Purpose – The purpose of this paper is to discuss some ethical issues in the internet encounter between customer and bank. Empirical data related to the difficulties that customers have when they deal with the bank through internet technology and electronic banking. The authors discuss...... the difficulties that customers expressed from an ethical standpoint. Design/methodology/approach – The key problem of the paper is “how does research handle the user's lack of competence in a web-based commercial environment?” The authors illustrate this ethical dilemma with data from a Danish Bank collected...

  20. Focus Groups as Transformative Spiritual Encounters

    Directory of Open Access Journals (Sweden)

    Sharon Moloney PhD

    2011-03-01

    Full Text Available Focus groups are a valuable method for exploring the construction and negotiation of meanings. In her doctoral research the author explored how Australian women's experiences of menstruation, birth, and spirituality are invested with meaning and how that meaning influences and shapes those experiences. The focus group has been described as a potentially liminal space, which enables the discussion of taboo subjects by breaking the ice and giving people permission to comment. In addition, she discovered that the groups could be occasions of empowerment and transformation for both participants and researcher. In a way that far exceeded her expectations, the group format was ideally suited to feminist research and the organic inquiry methodology she used. Some groups became deeply spiritual encounters that were nourishing and transformative for all. This article explores how focus groups can be vehicles of spiritual transformation, examining one group in particular to highlight the points raised.

  1. Rhinoplasty Education Using a Standardized Patient Encounter

    Directory of Open Access Journals (Sweden)

    Eric J. Wright

    2016-09-01

    Full Text Available BackgroundComprehensive aesthetic surgery training continues to be a challenge for residency programs. Our residency program developed a rhinoplasty-based objective structured clinical examination (OSCE based upon validated methods as part of the residency education curriculum. We report our experience with the rhinoplasty-based OSCE and offer guidance to its incorporation within residency programs.MethodsThe encounter involved resident evaluation and operative planning for a standardized patient desiring a rhinoplasty procedure. Validated OSCE methods currently used at our medical school were implemented. Residents were evaluated on appropriate history taking, physical examination, and explanation to the patient of treatment options. Examination results were evaluated using analysis of variance (statistical significance P<0.05.ResultsTwelve residents completed the rhinoplasty OSCE. Medical knowledge assessment showed increasing performance with clinical year, 50% versus 84% for postgraduate year 3 and 6, respectively (P<0.005. Systems-based practice scores showed that all residents incorrectly submitted forms for billing and operative scheduling. All residents confirmed that the OSCE realistically represents an actual patient encounter. All faculty confirmed the utility of evaluating resident performance during the OSCE as a useful assessment tool for determining the Next Accreditation System Milestone level.ConclusionsAesthetic surgery training for residents will require innovative methods for education. Our examination showed a program-educational weakness in billing/coding, an area that will be improved upon by topic-specific lectures. A thoroughly developed OSCE can provide a realistic educational opportunity to improve residents' performance on the nonoperative aspects of rhinoplasty and should be considered as an adjunct to resident education.

  2. Discriminative predation: Simultaneous and sequential encounter experiments

    Institute of Scientific and Technical Information of China (English)

    C.D.BEATTY; D.W.FRANKS

    2012-01-01

    There are many situations in which the ability of animals to distinguish between two similar looking objects can have significant selective consequences.For example,the objects that require discrimination may be edible versus defended prey,predators versus non-predators,or mates of varying quality.Working from the premise that there are situations in which discrimination may be more or less successful,we hypothesized that individuals find it more difficult to distinguish between stimuli when they encounter them sequentially rather than simultaneously.Our study has wide biological and psychological implications from the perspective of signal perception,signal evolution,and discrimination,and could apply to any system where individuals are making relative judgments or choices between two or more stimuli or signals.While this is a general principle that might seem intuitive,it has not been experimentally tested in this context,and is often not considered in the design of models or experiments,or in the interpretation of a wide range of studies.Our study is different from previous studies in psychology in that a) the level of similarity of stimuli are gradually varied to obtain selection gradients,and b) we discuss the implications of our study for specific areas in ecology,such as the level of perfection of mimicry in predator-prey systems.Our experiments provide evidence that it is indeed more difficult to distinguish between stimuli - and to learn to distinguish between stimuli - when they are encountered sequentially rather than simultaneously,even if the intervening time interval is short.

  3. Exchange interaction radically changes behavior of a quantum particle in a classically forbidden region: simple model

    CERN Document Server

    Flambaum, V V

    2009-01-01

    Exchange interaction strongly influences the long-range behavior of localized electron orbitals and quantum tunneling amplitudes.In the Hartree-Fock approximation the exchange produces a power-law decay instead of the usual exponential decrease at large distances. To show that this effect is real (i.e. not a result of the approximation) we consider a simple model where different effects may be accurately analyzed. Applications include huge enhancement of inner electron ionization by a static electric field or laser field considered in Ref. M. Ya. Amusia, arxiv:0904.4395

  4. Guest-Host Encounters in Diaspora-Heritage Tourism: The Taglit-Birthright Israel Mifgash (Encounter)

    Science.gov (United States)

    Sasson, Theodore; Mittelberg, David; Hecht, Shahar; Saxe, Leonard

    2011-01-01

    More than 300,000 diaspora Jewish young adults and tens of thousands of their Israeli peers have participated in structured, cross-cultural encounters--"mifgashim"--in the context of an experiential education program known as Taglit-Birthright Israel. Drawing on field observations, interviews, and surveys, the formal and informal…

  5. Guest-Host Encounters in Diaspora-Heritage Tourism: The Taglit-Birthright Israel Mifgash (Encounter)

    Science.gov (United States)

    Sasson, Theodore; Mittelberg, David; Hecht, Shahar; Saxe, Leonard

    2011-01-01

    More than 300,000 diaspora Jewish young adults and tens of thousands of their Israeli peers have participated in structured, cross-cultural encounters--"mifgashim"--in the context of an experiential education program known as Taglit-Birthright Israel. Drawing on field observations, interviews, and surveys, the formal and informal…

  6. Integration with the LHC of Electron Interaction Region Optics for a Ring-ring LHeC

    CERN Document Server

    Thompson, L; Kostka, P; Bernard, NR; Burkhardt, H; Fitterer, M; Klein, M; Holzer, BJ

    2012-01-01

    The Large Hadron Electron Collider (LHeC) project is a proposal to study e-p and e-A interactions at the LHC. One design uses an electron synchrotron to collide a 60 GeV e beam with the 7 TeV proton beam. Designing a new accelerator around the existing LHC machine poses unique challenges, particularly in the interaction region (IR). The electron beam must be quickly separated from the proton beam after the interaction point (IP) to avoid beam-beam effects, while not significantly reducing luminosity or producing large amounts of synchrotron radiation. The proton beam must pass through the electron optics, while the electron beam must avoid the proton optics. The long straight section requires bending in both planes to counteract the IP crossing angle and to displace the beam vertically from the electron machine to the proton IP. An achromatic bending scheme is used in the vertical plane to eliminate dispersion at the IP and provide an optics which is well matched to the LHeC ring lattice. The interaction reg...

  7. Doctor-patient interaction and informed consent in pediatric surgery: theory and reality in the regional practice

    Directory of Open Access Journals (Sweden)

    Sergio Luis González López

    2009-09-01

    Full Text Available Informed consent is a core element in the doctor-patient interaction. With the objective of reviewing the essentials and legal basis of its procedure and relation with pediatric surgery in the regional context we developed a bibliographic review of national and international biomedical publications. It is widely accepted that the recognition of patient´s autonomy and the informed consent process have led to a change in the doctor-patients interaction, which is closely linked to the pediatric surgical practice in the particular Cuban modern environment. In addition to the study of bioethical principles and their enforcement by those who are to provide medical services, it is also necessary to look for useful answers to bioethical questions affecting the legal tools that support the procedure.

  8. Environmental changes and human work in the region of the Upper Paraná River floodplain: processes and interactions

    Directory of Open Access Journals (Sweden)

    EA. Tomanik

    Full Text Available The environment and society constitute a complex of elements and interactions. Thus, an understanding of the processes in which the environment and psychosocial elements are involved may not be gained from knowledge of just one isolated variable. Based on such premises, the present paper, which summarizes the results of a series of studies, adopts work relationships as its main focus, but in addition, it has two complementary objectives. One is to present some analyses on the interaction between human actions and the environmental changes that have been taking place in the region of the Upper Paraná River floodplain and in its boundaries. A secondary aim is to show how those two factors have been changing people's working and living conditions and the identity configuration of some of the human groups that live at that site.

  9. Macroecological evidence for competitive regional-scale interactions between the two major clades of mammal carnivores (Feliformia and Caniformia).

    Science.gov (United States)

    Pedersen, Rasmus Østergaard; Sandel, Brody; Svenning, Jens-Christian

    2014-01-01

    Geographical gradients in species diversity are often explained by environmental factors such as climate and productivity. Biotic interactions play a key role in evolutionary diversification and may therefore also affect diversity patterns, but this has rarely been assessed. Here, we investigate whether negative competitive interactions shape the diversity patterns of the two major mammalian clades of carnivores, the suborders Caniformia (dogs and allies) and Feliformia (cats and allies) within the order Carnivora. We specifically test for a negative effect of feliform species richness on caniform species richness by a natural experiment, The Great American Interchange, which due to biogeographic lineage history and climate patterns caused tropical South America to be colonized by most caniform families, but only one feliform family. To this end we used regression modelling to investigate feliform and caniform richness patterns and their determinants with emphasis on contrasting the Old and New World tropics. We find that feliform richness is elevated in the Old World Tropics, while caniform richness is elevated in the New World Tropics. Models based on environmental variables alone underpredict caniform richness and overpredict feliform richness in the New World and vice versa in the Old World. We further show that models including feliform richness as a predictor for caniform species richness significantly improve predictions at the continental scale, albeit not at finer scales. Our results are consistent with a negative effect of feliforms on regional-scale caniform diversification within the tropics, probably indicating that niche space occupancy by the one clade constrains diversification in the other in the build-up of regional faunas, while negative interactions at smaller scales may be unimportant due to niche differentiation within the regional faunas.

  10. Macroecological evidence for competitive regional-scale interactions between the two major clades of mammal carnivores (Feliformia and Caniformia.

    Directory of Open Access Journals (Sweden)

    Rasmus Østergaard Pedersen

    Full Text Available Geographical gradients in species diversity are often explained by environmental factors such as climate and productivity. Biotic interactions play a key role in evolutionary diversification and may therefore also affect diversity patterns, but this has rarely been assessed. Here, we investigate whether negative competitive interactions shape the diversity patterns of the two major mammalian clades of carnivores, the suborders Caniformia (dogs and allies and Feliformia (cats and allies within the order Carnivora. We specifically test for a negative effect of feliform species richness on caniform species richness by a natural experiment, The Great American Interchange, which due to biogeographic lineage history and climate patterns caused tropical South America to be colonized by most caniform families, but only one feliform family. To this end we used regression modelling to investigate feliform and caniform richness patterns and their determinants with emphasis on contrasting the Old and New World tropics. We find that feliform richness is elevated in the Old World Tropics, while caniform richness is elevated in the New World Tropics. Models based on environmental variables alone underpredict caniform richness and overpredict feliform richness in the New World and vice versa in the Old World. We further show that models including feliform richness as a predictor for caniform species richness significantly improve predictions at the continental scale, albeit not at finer scales. Our results are consistent with a negative effect of feliforms on regional-scale caniform diversification within the tropics, probably indicating that niche space occupancy by the one clade constrains diversification in the other in the build-up of regional faunas, while negative interactions at smaller scales may be unimportant due to niche differentiation within the regional faunas.

  11. GRB Afterglow Blast Wave Encountering Sudden Circumburst Density Change Produces No Flares

    CERN Document Server

    Gat, Ilana; MacFadyen, Andrew

    2013-01-01

    Afterglows of gamma-ray bursts are observed to produce light curves with the flux following power law evolution in time. However, recent observations reveal bright flares at times on the order of minutes to days. One proposed explanation for these flares is the interaction of a relativistic blast wave with a circumburst density transition. In this paper, we model this type of interaction computationally in one and two dimensions, using a relativistic hydrodynamics code with adaptive mesh refinement called ram, and analytically in one dimension. We simulate a blast wave traveling in a stellar wind environment that encounters a sudden change in density, followed by a homogeneous medium, and compute the observed radiation using a synchrotron model. We show that flares are not observable for an encounter with a sudden density increase, such as a wind termination shock, nor for an encounter with a sudden density decrease. Furthermore, by extending our analysis to two dimensions, we are able to resolve the spreadin...

  12. No flares from GRB afterglow blast waves encountering sudden circumburst density change

    CERN Document Server

    Gat, Ilana; MacFadyen, Andrew

    2013-01-01

    Afterglows of gamma-ray bursts are observed to produce light curves with the flux following power law evolution in time. However, recent observations reveal bright flares at times on the order of minutes to days. One proposed explanation for these flares is the interaction of a relativistic blast wave with a circumburst density transition. In this paper, we model this type of interaction computationally in one and two dimensions, using a relativistic hydrodynamics code with adaptive mesh refinement called RAM, and analytically in one dimension. We simulate a blast wave traveling in a stellar wind environment that encounters a sudden change in density, followed by a homogeneous medium, and compute the observed radiation using a synchrotron model. We show that flares are not observable for an encounter with a sudden density increase, such as a wind termination shock, nor for an encounter with a sudden density decrease. Furthermore, by extending our analysis to two dimensions, we are able to resolve the spreadin...

  13. Innovation from the ICT-based service encounter

    DEFF Research Database (Denmark)

    Henten, Anders

    2012-01-01

    The pupose of the paper is to develop a framework for analyzing the dynamics of innovations emanating from the ICT-based service encounters. Many innovations are based on the direct encounter between employees and customers, and the paper aims to extend the analysis of such encounters to ICT...

  14. A new WRF-Chem treatment for studying regional scale impacts of cloud-aerosol interactions in parameterized cumuli

    Science.gov (United States)

    Berg, L. K.; Shrivastava, M.; Easter, R. C.; Fast, J. D.; Chapman, E. G.; Liu, Y.

    2014-04-01

    A new treatment of cloud-aerosol interactions within parameterized shallow and deep convection has been implemented in WRF-Chem that can be used to better understand the aerosol lifecycle over regional to synoptic scales. The modifications to the model to represent cloud-aerosol interactions include treatment of the cloud droplet number mixing ratio; key cloud microphysical and macrophysical parameters (including the updraft fractional area, updraft and downdraft mass fluxes, and entrainment) averaged over the population of shallow clouds, or a single deep convective cloud; and vertical transport, activation/resuspension, aqueous chemistry, and wet removal of aerosol and trace gases in warm clouds. These changes have been implemented in both the WRF-Chem chemistry packages as well as the Kain-Fritsch cumulus parameterization that has been modified to better represent shallow convective clouds. Preliminary testing of the modified WRF-Chem has been completed using observations from the Cumulus Humilis Aerosol Processing Study (CHAPS) as well as a high-resolution simulation that does not include parameterized convection. The simulation results are used to investigate the impact of cloud-aerosol interactions on regional scale transport of black carbon (BC), organic aerosol (OA), and sulfate aerosol. Based on the simulations presented here, changes in the column integrated BC can be as large as -50% when cloud-aerosol interactions are considered (due largely to wet removal), or as large as +40% for sulfate in non-precipitating conditions due to the sulfate production in the parameterized clouds. The modifications to WRF-Chem version 3.2.1 are found to account for changes in the cloud drop number concentration (CDNC) and changes in the chemical composition of cloud-drop residuals in a way that is consistent with observations collected during CHAPS. Efforts are currently underway to port the changes described here to WRF-Chem version 3.5, and it is anticipated that they

  15. Regional Aerosol Forcing over India: Preliminary Results from the South West Asian Aerosol-Monsoon Interactions (SWAAMI) Aircraft Experiment

    Science.gov (United States)

    Morgan, W.; Brooks, J.; Fox, C.; Haslett, S.; Liu, D.; Kompalli, S. K.; Pathak, H.; Manoj, M. R.; Allan, J. D.; Haywood, J. M.; Highwood, E.; Langridge, J.; Nanjundaiah, R. S.; Krishnamoorthy, K.; Babu, S. S.; Satheesh, S. K.; Turner, A. G.; Coe, H.

    2016-12-01

    Aerosol particles from multiple sources across the Indian subcontinent build up to form a dense and extensive haze across the region in advance of the monsoon. These aerosols are thought to perturb the regional radiative balance and hydrological cycle, which may have a significant impact on the monsoon circulation, as well as influencing the associated cloud and rainfall of the system. However the nature and magnitude of such impacts are poorly understood or constrained. Major uncertainties relevant to the regional aerosol burden include its vertical distribution, the relative contribution of different pollution sources and natural emissions and the role of absorbing aerosol species (black carbon and mineral dust). The South West Asian Aerosol-Monsoon Interactions (SWAAMI) project sought to address these major uncertainties by conducting an airborne experiment during June/July 2016 on-board the UK Facility for Airborne Atmospheric Measurement (FAAM) BAe-146 research aircraft. Based out of Lucknow in the), The aircraft conducted multiple flights from Lucknow in the heart of the Indo-Gangetic Plain (IGP) in advance of the monsoon and during the onset phase. The spatial and vertical distribution of aerosol was evaluated across northern India, encompassing drier desert-like regions to the west, heavily populated urban and industrial centres over the IGP and air masses in outflow regions to the south-east towards the Bay of Bengal. Principal measurements included aerosol chemical composition using an Aerodyne Aerosol Mass Spectrometer and a DMT Single Particle Soot Photometer, alongside a Leosphere backscatter LIDAR. Sulphate was a major contributor to the aerosol burden across India, while the organic aerosol was elevated and more dominant over the most polluted regions of the IGP. Substantial aerosol concentrations were frequently observed up to altitudes of approximately 6km, with notable changes in aerosol chemical and physical properties when comparing different

  16. Vibronic interactions in NO 3: from the 2E' origin region to the NO + O 2 reactive channel

    Science.gov (United States)

    Valachovic, L.; Riehn, C.; Mikhaylichenko, K.; Wittig, C.

    1996-08-01

    LIF spectra of expansion-cooled NO 3 in the region 595-666 nm reveal vibronic interactions responsible for 2E' radiationless decay. A hierarchy of coupling strengths is suggested. Due the large atomic masses, tunneling results in small unimolecular decomposition rates below the NO + O 2 barrier on the 2A' 2 ground potential surface. These have been observed via their quenching of long-lived NO 3 fluorescence, and rates as small as 3 × 10 4 s -1 are reported. This is 5 orders of magnitude smaller than the rate just above the barrier, which had been determined previously by using the ultrafast pump-probe technique.

  17. Quench performance and mechanical behavior of the first Fermilab- built prototype high gradient quadrupole for the LHC interaction regions

    CERN Document Server

    Andreev, N; Bauer, P; Bossert, R; Brandt, J; Carson, J; Caspi, S; Chichili, D R; Di Marco, J; Fehér, S; Ghosh, A; Glass, H; Kerby, J S; Lamm, M J; Makarov, A; McInturff, A D; Nicol, T H; Nobrega, A; Novitski, I; Orris, D; Peterson, T; Rabehl, Roger Jon; Robotham, W; Scanlan, R M; Schlabach, P; Sylvester, C D; Strait, J B; Tartaglia, A; Tompkins, J C; Velev, G V; Yadav, S; Zlobin, A V

    2002-01-01

    As part of the US LHC program to provide high gradient superconducting quadrupoles for the LHC interaction regions, a 5.5 meter long prototype magnet has been built and tested horizontally in a production type cryostat at Fermilab. This prototype magnet was used to validate the mechanical and magnetic design, production fabrication and assembly tooling. The first prototype magnet has met the LHC requirements of operating at 215 T/m with excellent magnetic field harmonics. This paper summarizes the test results of this magnet, including quench tests and mechanical behavior over several thermal cycles. (11 refs).

  18. Final-state interaction correction to the electromagnetic nucleon form factors in the time-like region

    Energy Technology Data Exchange (ETDEWEB)

    Van de Wiele, Jacques; Ong, Saro [Universite de Paris-Sud, Institut de Physique Nucleaire d' Orsay (UMR 8608), IN2P3-CNRS, Orsay Cedex (France)

    2015-10-15

    We study the strong energy dependence of the proton electromagnetic form factors in the time-like region, taking into account the one-pion-exchange final-state interaction in a covariant way. This effect is quantified in terms of the corrected Dirac F{sub 1} and Pauli F{sub 2} form factors and in the commonly used electric G{sub E} and magnetic G{sub M} ones. Our results on the ratio G{sub E} /G{sub M} depend only on the values of two free parameters and allow significant comparisons with the BaBar data. (orig.)

  19. Organised cultural encounters and social integration

    DEFF Research Database (Denmark)

    Kappa, Katherine

    2017-01-01

    takes an explorative, social interactional approach. The paper gives examples of a common occurrence: specifically, how the volunteers actively seek out shared identities, or co-membership, with the asylum seekers and refugees as language learners. It is argued that this interactional choice highlights...

  20. Neutrino Interaction Calculations from MeV to GeV Region

    CERN Document Server

    Amaro, J E; Valverde, M; Vicente-Vacas, M J

    2008-01-01

    The Quasi-Elastic (QE) contribution of the nuclear inclusive electron model developed in Nucl. Phys. A627 543 (1997) is extended to the study of neutrino/antineutrino Charged Current (CC) and Neutral Current (NC) induced nuclear reactions at intermediate energies. Long range nuclear (RPA) correlations, Final State Interaction (FSI) and Coulomb corrections are included within the model. RPA correlations are shown to play a crucial role in the whole range (100--500 MeV) of studied neutrino energies. Results for inclusive muon capture for different nuclei through the Periodic Table are also discussed. In addition, and by means of a Monte Carlo cascade method to account for the rescattering of the outgoing nucleon, we also study the CC and NC inclusive one nucleon knockout reactions off nuclei.

  1. Unexplored regions in QFT: delocalization of quantum matter through interactions with zero mass potentials

    CERN Document Server

    Schroer, Bert

    2010-01-01

    Massive quantum matter of prescribed spin permits infinitely many possibilities of covariantization in terms of spinorial (undotted/dotted) pointlike fields, whereas massless finite helicity representations lead to large gap in this spinorial spectrum which quantum field theorists usually try to fill by inventing an indefinite metric vectorpotential (Gupta-Bleuler, BRST) outside the quantum theoretic realm. Only after completing the computation the expecration of the gauge invariant observables are obtained. The full range of covariant possiblities (without indefinite metric) is restored if one allows localization along semiinfinite strings in addition to pointlike localization. These stringlike potentials fluctuate in the direction of the string (points in a lower de Sitter space) and absorb part of the short distance singularity: there always exists a potential with the smallest short distance dimension allowed by unitarity: sdd=1. In case the interaction with the potential remains linear (QED), there is a ...

  2. Numerical Simulation of Fault Interaction in a Trans-Tensional Setting, the La Paz Los Cabos Region, Baja California, Mexico.

    Science.gov (United States)

    Zielke, O.; Arrowsmith, R. J.

    2006-12-01

    A number of medium to large normal faulting earthquakes occurred in the La Paz-Los Cabos region, at the tip of Baja California, within the last four decades. They (along with the tectonic geomorphology of the fault zones on the Peninsula) demonstrate that the existing structures in the area are active and capable of hazardous earthquakes. The goal of this study is to understand how the individual active faults in this region affect the behavior of the fault system as a whole. What role does fault interaction (i.e., stress transfer) and earthquake triggering play in the La Paz-Los Cabos region? Do we know all the significant, active and therefore hazardous structures that are part of the fault system? Are these structures capable of releasing the tectonically accumulated strain? What role does that fault system play in the regional, trans-tensional setting? To approach these questions we utilize a numerical model, based on derivations by Okada (1992), with which we compute the strain distribution and Coulomb failure stress for a given (frictionless) displacement along a rectangular fault patch and its interactions with other faults of the fault array. Beginning with simple geometric models of the fault system in the La Paz-Los Cabos region, we investigate under what conditions individual earthquakes may have triggered subsequent events. We focused on the M =5.6 event on April 4th 1969 that may have had an effect on the timing of the M=6.2 event on June 30th 1995. The proximity of these two earthquakes (epicenters only 60km apart) supports the idea that stress transfer caused by the 1969 event may have altered the seismic cycle of the fault activated in 1995. Because fault geometry and slip distribution during these two events are not well known, we explore the parameter space to learn under what conditions the 1969 event may have triggered the 1995 event. We apply the empirical relations among magnitude, fault geometry, and displacement, derived by Wells

  3. A process study of the interaction of tidal currents, tidal mixing and density gradients in a region of freshwater influence

    Science.gov (United States)

    Xing, Jiuxing; Chen, Shengli

    2017-08-01

    A three dimensional unstructured grid model of the west coast of Britain is used to study the process of the interaction of tidal currents, tidal mixing and density gradient in the Liverpool Bay region. Calculations with M2 tidal forcing and omitting freshwater discharge show that tidal currents in the region are strong (of order 1 ms- 1), with tidal current ellipses essentially rectilinear in the surface and bottom. In the absence of tidal forcing, the freshwater is confined to a thin surface layer. With the inclusion of tidal mixing the surface layer thickens, and in the shallow water area mixed layer occupies the whole water depth. This has a significant effect of reducing its lateral spread. A detailed study of time series of velocity, salinity and turbulence reveals that at flood tide, more saline water is advected into the coastal region and rapid vertical mixing occurs, whereas at ebb tide, fresher water is advected over more saline water. The induced strong pycnocline uncouples surface and bottom layers leading to more circular tidal ellipses which rotate in opposite directions in the vertical, as found in observations. The three dimensional nature of the model reveals that this process involves both horizontal and vertical density gradients, and shows significant horizontal variability in the Liverpool Bay region.

  4. Evaluating Spatial Interaction Models for Regional Mobility in Sub-Saharan Africa.

    Science.gov (United States)

    Wesolowski, Amy; O'Meara, Wendy Prudhomme; Eagle, Nathan; Tatem, Andrew J; Buckee, Caroline O

    2015-07-01

    Simple spatial interaction models of human mobility based on physical laws have been used extensively in the social, biological, and physical sciences, and in the study of the human dynamics underlying the spread of disease. Recent analyses of commuting patterns and travel behavior in high-income countries have led to the suggestion that these models are highly generalizable, and as a result, gravity and radiation models have become standard tools for describing population mobility dynamics for infectious disease epidemiology. Communities in Sub-Saharan Africa may not conform to these models, however; physical accessibility, availability of transport, and cost of travel between locations may be variable and severely constrained compared to high-income settings, informal labor movements rather than regular commuting patterns are often the norm, and the rise of mega-cities across the continent has important implications for travel between rural and urban areas. Here, we first review how infectious disease frameworks incorporate human mobility on different spatial scales and use anonymous mobile phone data from nearly 15 million individuals to analyze the spatiotemporal dynamics of the Kenyan population. We find that gravity and radiation models fail in systematic ways to capture human mobility measured by mobile phones; both severely overestimate the spatial spread of travel and perform poorly in rural areas, but each exhibits different characteristic patterns of failure with respect to routes and volumes of travel. Thus, infectious disease frameworks that rely on spatial interaction models are likely to misrepresent population dynamics important for the spread of disease in many African populations.

  5. Evaluating Spatial Interaction Models for Regional Mobility in Sub-Saharan Africa.

    Directory of Open Access Journals (Sweden)

    Amy Wesolowski

    2015-07-01

    Full Text Available Simple spatial interaction models of human mobility based on physical laws have been used extensively in the social, biological, and physical sciences, and in the study of the human dynamics underlying the spread of disease. Recent analyses of commuting patterns and travel behavior in high-income countries have led to the suggestion that these models are highly generalizable, and as a result, gravity and radiation models have become standard tools for describing population mobility dynamics for infectious disease epidemiology. Communities in Sub-Saharan Africa may not conform to these models, however; physical accessibility, availability of transport, and cost of travel between locations may be variable and severely constrained compared to high-income settings, informal labor movements rather than regular commuting patterns are often the norm, and the rise of mega-cities across the continent has important implications for travel between rural and urban areas. Here, we first review how infectious disease frameworks incorporate human mobility on different spatial scales and use anonymous mobile phone data from nearly 15 million individuals to analyze the spatiotemporal dynamics of the Kenyan population. We find that gravity and radiation models fail in systematic ways to capture human mobility measured by mobile phones; both severely overestimate the spatial spread of travel and perform poorly in rural areas, but each exhibits different characteristic patterns of failure with respect to routes and volumes of travel. Thus, infectious disease frameworks that rely on spatial interaction models are likely to misrepresent population dynamics important for the spread of disease in many African populations.

  6. Long-term Radiation Budget Variability in the Northern Eurasian Region: Assessing the Interaction with Fire

    Science.gov (United States)

    Stackhouse, P. W.; Soja, A. J.; Zhang, T.; Mikovitz, J. C.

    2013-12-01

    In terms of global change, boreal regions are particularly important, because significant warming and change are already evident and significant future warming is predicted. Mean global air temperature has increased by 0.74°C in the last century, and temperatures are predicted to increase by 1.8°C to 4°C by 2090, depending on the Inter-governmental Panel on Climate Change (IPCC) scenario. Some of the greatest temperature increases are currently found in the Northern Eurasian winter and spring, which has led to longer growing seasons, increased potential evapotranspiration and extreme fire weather [Groisman et al., 2007]. In the Siberian Sayan, winter temperatures have already exceeded a 2090 Hadley Centre scenario (HadCM3GGa1) [Soja et al., 2007]. There is evidence of climate-induced change across the circumboreal in terms of increased infestations, alterations in vegetation and increased fire regimes (area burned, fire frequency, severity and number of extreme fire seasons). In this paper, we analyzed long-term surface radiation data sets from the NASA/GEWEX (Global Energy and Water Exchanges) Surface Radiation Budget data products, CERES Surface EBAF and SYN data products and also the available surface radiation measurements in the region. First, we show that during overlap years SRB and CERES data products agree very well in terms of anomalies and we'll use this fact to evaluate 30 years of satellite based estimates of the variability of downwelling SW parameters first corresponding to locations of surface measurements and then for the region as a whole. We also show the observed variability of other SW components such as the net SW and the albedo. Next we assess the variability of the downward and LW fluxes over time and compare these to variability observed in the surface temperature and other meteorological measurements. We assess anomalies on various spatial scales. Finally, we assess the correlation of this variability in specific locations to known fire

  7. Modelling the interactions between regional farming structure, nitrogen losses and environmental regulation

    DEFF Research Database (Denmark)

    Happe, Kathrin; Hutchings, Nick; Dalgaard, Tommy;

    2011-01-01

    Changes in the structure of agriculture are known to affect emissions of environmental pollutants from agriculture. Such changes are often driven by structural changes in agricultural production, so structural changes are likely to have indirect effects on emissions. In a pilot study, we consider...... how linking two complementary simulation models might be used to explore these effects. The agent-based AgriPoliS model was used to simulate the structural dynamics of agricultural production. The results from AgriPoliS were passed via a number of intermediate models to the Farm-N model, which...... was used to estimate the nitrogen surplus and losses from each farm for each year. The modelling complex was exercised by simulating the effects of two plausible policy scenarios for each of 14 years. The initial sizes and types of farms were based on statistics from a region in Denmark and the farms were...

  8. New techniques to control salinity-wastewater reuse interactions in golf courses of the Mediterranean regions

    Science.gov (United States)

    Beltrao, J.; Costa, M.; Rosado, V.; Gamito, P.; Santos, R.; Khaydarova, V.

    2003-04-01

    Due to the lack water around the Mediterranean regions, potable water luxurious uses - as in golf courses - are increasingly contested. In order to solve this problem, non conventional water resources (effluent, gray, recycled, reclaimed, brackish), like treated wastewater, for irrigation gained increasing role in the planning and development of additional water supplies in golf courses. In most cases, the intense use of effluent for irrigation attracted public awareness in respect of contaminating pathogens and heavy metals. The contaminating effect of salinity in soil and underground water is very often neglected. The objective of this work is to present the conventional techniques to control salinity of treated wastewater and to present some results on new clean techniques to solve this problem, in the framework of the INCO-COPERNICUS project (no. IC-15CT98-0105) "Adaptation of Efficient Water Use Criteria in Marginal Regions of Europe and Middle Asia with Scarce Sources Subject to Environmental Control, Climate Change and Socio-Economic Development" and of the INCO-DC project (no. IC18-CT98-0266) "Control of Salination and Combating Desertification Effects in the Mediterranean Region. Phase II". Saline water is the most common irrigation water in arid climates. Moreover, for each region treated wastewater is always more saline than tap water, and therefore, when treated wastewater is reused in golf courses, more salinity problems occur. Conventional techniques to combat the salination process in golf courses can be characterized by four generations: 1) Problem of root zone salination by soil leaching - two options can occur - when there is an impermeable layer, salts will be concentrated above this layer; on the other hand, when there is no impermeable layer, aquifers contamination can be observed; 2) Use of subsurface trickle irrigation - economy of water, and therefore less additional salts; however the problem of groundwater contamination due to natural rain

  9. Interaction of neutral atoms and plasma turbulence in the tokamak edge region

    Science.gov (United States)

    Wersal, Christoph; Ricci, Paolo; Jorge, Rogerio; Morales, Jorge; Paruta, Paola; Riva, Fabio

    2016-10-01

    A novel first-principles self-consistent model that couples plasma and neutral atom physics suitable for the simulation of turbulent plasma behaviour in the tokamak edge region has been developed and implemented in the GBS code. While the plasma is modelled by the drift-reduced two fluid Braginskii equations, a kinetic model is used for the neutrals, valid in short and in long mean free path scenarios. The model includes ionization, charge-exchange, recombination, and elastic collisional processes. The model was used to study the transition form the sheath to the conduction limited regime, to include gas puffs in the simulations, and to investigate the interplay between neutral atoms and plasma turbulence.

  10. Simulated interaction of MHD shock waves with a complex network-like region

    CERN Document Server

    Santamaria, Irantzu C; Collados, Manuel; de Vicente, Angel

    2016-01-01

    We provide estimates of the wave energy reaching the solar chromosphere and corona in a network-like magnetic field topology, including a coronal null point. The waves are excited by an instantaneous strong subphotospheric source and propagate through the subphotosphere, photosphere, chromosphere, transition region, and corona with the plasma beta and other atmospheric parameters varying by several orders of magnitude. We compare two regimes of the wave propagation: a linear and nonlinear regime. While the amount of energy reaching the corona is similar in both regimes, this energy is transmitted at different frequencies. In both cases the dominant periods of waves at each height strongly depend on the local magnetic field topology, but this distribution is only in accordance with observations in the nonlinear case.

  11. A Brief Encounter Group Experience and Social Relationships in a Dormitory

    Science.gov (United States)

    Dies, Robert R.; Sadowsky, Richard

    1974-01-01

    The investigation examined the effects of a brief encounter group experience upon residents in a university dormitory. Women living on three separate floors were designated experimental subjects and provided with a group experience designed to encourage personal interaction, while women on two other floors were assigned to a control group. (Author)

  12. Studying Critical Classroom Encounters: The Experiences of Students in German College Education

    Science.gov (United States)

    Voss, Roediger

    2009-01-01

    Purpose: This paper seeks to explore satisfactory and unsatisfactory classroom (student-lecturer) encounters in higher education from a student's perspective. Design/methodology/approach: The critical incident technique (CIT) is used to categorise positive and negative student-lecturer interactions, to reveal quality dimensions of the lecturer,…

  13. First Encounters: Native Americans and Europeans in the Mississippi Valley. [CD-ROM].

    Science.gov (United States)

    Sabo, George, III; Restrepo, Luis Fernando; Jones, Linda

    This CD-ROM provides interactive, multimedia software that enables students to investigate many aspects of Native American and European encounters in the Mississippi Valley through study of original historical sources, including texts, maps, artworks, and archaeological finds. The Lower Mississippi Valley was chosen as the study area because of…

  14. Standardized Patient Encounters Improved Athletic Training Students' Confidence in Clinical Evaluations

    Science.gov (United States)

    Armstrong, Kirk J.; Jarriel, Amanda J.

    2015-01-01

    Context: Researchers have reported that interacting with standardized patients (SPs) is a worthwhile and realistic experience for athletic training (AT) students. These encounters enhance students' interviewing skills, confidence as a clinician, clinical skill development, and interpersonal communication. Objective: To determine how SP encounters…

  15. International workshop on final focus and interaction regions of next generation linear colliders: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1992-11-01

    The first day of the workshop was devoted to four plenary ``issues`` talks, one for each working group: Beam-Beam Interaction, Detector, Hardware, and Optical Design. The last day was devoted to plenary talks summarizing the activities of the working groups. Each of the three remaining days there,was a short morning plenary devoted to a brief summary of the preceding day and an announcement of planned working group discussions for that day. The transparencies for the ``issues`` and ``summary`` talks are included in this volume, along with some remarks from the working group chairpersons. Very briefly, the beam-beam group continued to address the quantitative study of QED induced backgrounds, and attempted to better understand the nature and prevalence of QCD millijets. The detector group attempted to identify the impact on masking and detector design of the beam-beam backgrounds, the synchrotron radiation induced backgrounds from beam halos and muon backgrounds produced primarily in collimators. Nanosecond timing elements needed in conjunction with multi-bunch operation were discussed. The hardware group addressed the problem of magnet design and support, especially the final doublet magnets suspended within the detector environment, and instrumentation issues, such as high resolution beam position monitors. The optics group discussed new final focus system ideas, collimator design, and improvement of beamline tolerances. If you were not here to participate, we hope that this volume will help you in your orientation to these problems.

  16. International workshop on final focus and interaction regions of next generation linear colliders: Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    1992-01-01

    The first day of the workshop was devoted to four plenary issues'' talks, one for each working group: Beam-Beam Interaction, Detector, Hardware, and Optical Design. The last day was devoted to plenary talks summarizing the activities of the working groups. Each of the three remaining days there,was a short morning plenary devoted to a brief summary of the preceding day and an announcement of planned working group discussions for that day. The transparencies for the issues'' and summary'' talks are included in this volume, along with some remarks from the working group chairpersons. Very briefly, the beam-beam group continued to address the quantitative study of QED induced backgrounds, and attempted to better understand the nature and prevalence of QCD millijets. The detector group attempted to identify the impact on masking and detector design of the beam-beam backgrounds, the synchrotron radiation induced backgrounds from beam halos and muon backgrounds produced primarily in collimators. Nanosecond timing elements needed in conjunction with multi-bunch operation were discussed. The hardware group addressed the problem of magnet design and support, especially the final doublet magnets suspended within the detector environment, and instrumentation issues, such as high resolution beam position monitors. The optics group discussed new final focus system ideas, collimator design, and improvement of beamline tolerances. If you were not here to participate, we hope that this volume will help you in your orientation to these problems.

  17. Heterodynes dominate precipitation isotopes in the East Asian monsoon region, reflecting interaction of multiple climate factors

    Science.gov (United States)

    Thomas, Elizabeth K.; Clemens, Steven C.; Sun, Youbin; Prell, Warren L.; Huang, Yongsong; Gao, Li; Loomis, Shannon; Chen, Guangshan; Liu, Zhengyu

    2016-12-01

    For the past decade, East Asian monsoon history has been interpreted in the context of an exceptionally well-dated, high-resolution composite record of speleothem oxygen isotopes (δ18Ocave) from the Yangtze River Valley. This record is characterized by a unique spectral response, with variance concentrated predominantly within the precession band and an enigmatic lack of variance at the eccentricity and obliquity bands. Here we examine the spectral characteristics of all existing >250-kyr-long terrestrial water isotope records in Asia, including a new water isotope record using leaf wax hydrogen isotope ratios from the Chinese Loess Plateau. There exist profound differences in spectral characteristics among all orbital-scale Asian water isotope records. We demonstrate that these differences result from latitudinal gradients in the influence of the winter and summer monsoons, both of which impact climate and water isotopes throughout East Asia. Water isotope records therefore do not reflect precipitation during a single season or from a single circulation system. Rather, water isotope records in East Asia reflect the complex interplay of oceanic and continental moisture sources, operating at multiple Earth-orbital periods. These non-linear interactions are reflected in water isotope spectra by the presence of heterodynes. Although complex, we submit that water isotope records, when paired with rapidly developing isotope-enabled model simulations, will have the potential to elucidate mechanisms causing seasonal precipitation variability and moisture source variability in East Asia.

  18. A laser-based beam profile monitor for the SLC/SLD interaction region

    Science.gov (United States)

    Ross, M. C.; Alley, R.; Arnett, D.; Bong, E.; Colocho, W.; Frisch, J.; Horton-Smith, S.; Inman, W.; Jobe, K.; Kotseroglou, T.; McCormick, D.; Nelson, J.; Scheeff, M.; Wagner, S.

    1997-01-01

    Beam size estimates made using beam-beam deflections are used for optimization of the Stanford Linear Collider (SLC) electron-positron beam sizes. Typical beam sizes and intensities expected for 1996 operations are 2.1×0.6 μm (x,y) at 4.0×1010 particles per pulse. Conventional profile monitors, such as scanning wires, fail at charge densities well below this. Since the beam-beam deflection does not provide single beam size information, another method is needed for interaction point (IP) beam size optimization. The laser-based profile monitor uses a finely focused, 350-nm, wavelength-tripled yttrium-lithium-flouride (YLF) laser pulse that traverses the particle beam path about 29 cm away from the e+/e- IP. Compton scattered photons and degraded e+/e- are detected as the beam is steered across the laser pulse. The laser pulse has a transverse size of 380 nm and a Rayleigh range of about 5 μm. This is adequate for present or planned SLC beams. Design and preliminary results will be presented.

  19. CORONAL HEATING BY THE INTERACTION BETWEEN EMERGING ACTIVE REGIONS AND THE QUIET SUN OBSERVED BY THE SOLAR DYNAMICS OBSERVATORY

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Jun; Zhang, Bin; Li, Ting; Yang, Shuhong; Zhang, Yuzong; Li, Leping [Key Laboratory of Solar Activity, National Astronomical Observatories, Chinese Academy of Sciences, Beijing 100012 (China); Chen, Feng; Peter, Hardi, E-mail: zjun@nao.cas.cn, E-mail: liting@nao.cas.cn, E-mail: shuhongyang@nao.cas.cn, E-mail: yuzong@nao.cas.cn, E-mail: lepingli@nao.cas.cn, E-mail: chen@mps.mpg.de, E-mail: peter@mps.mpg.de [Max-Planck Institute for Solar System Research (MPS), D-37077, Göttingen (Germany)

    2015-02-01

    The question of what heats the solar corona remains one of the most important puzzles in solar physics and astrophysics. Here we report Solar Dynamics Observatory Atmospheric Imaging Assembly observations of coronal heating by the interaction between emerging active regions (EARs) and the surrounding quiet Sun (QS). The EARs continuously interact with the surrounding QS, resulting in dark ribbons which appear at the boundary of the EARs and the QS. The dark ribbons visible in extreme-ultraviolet wavelengths propagate away from the EARs with speeds of a few km s{sup −1}. The regions swept by the dark ribbons are brightening afterward, with the mean temperature increasing by one quarter. The observational findings demonstrate that uninterrupted magnetic reconnection between EARs and the QS occurs. When the EARs develop, the reconnection continues. The dark ribbons may be the track of the interface between the reconnected magnetic fields and the undisturbed QS’s fields. The propagating speed of the dark ribbons reflects the reconnection rate and is consistent with our numerical simulation. A long-term coronal heating which occurs in turn from nearby the EARs to far away from the EARs is proposed.

  20. Similar interactions of the poliovirus and rhinovirus 3D polymerases with the 3' untranslated region of rhinovirus 14.

    Science.gov (United States)

    Meredith, J M; Rohll, J B; Almond, J W; Evans, D J

    1999-12-01

    We showed previously that a human rhinovirus 14 (HRV14) 3' untranslated region (3' UTR) on a poliovirus genome was able to replicate with nearly wild-type kinetics (J. B. Rohll, D. H. Moon, D. J. Evans, and J. W. Almond, J. Virol 69:7835-7844, 1995). This enabled the HRV14 single 3' UTR stem-loop structure to be studied in combination with a sensitive reporter system, poliovirus FLC/REP, in which the capsid coding region is replaced by an in-frame chloramphemicol acetyltransferase (CAT) gene. Using such a construct, we identified a mutant (designated mut4), in which the structure and stability of the stem were predicted to be maintained, that replicated very poorly as determined by its level of CAT activity. The effect of this mutant 3' UTR on replication has been further investigated by transferring it onto the full-length cDNAs of both poliovirus type 3 (PV3) and HRV14. Virus was recovered with a parental plaque phenotype at a low frequency, indicating the acquisition of compensating changes, which sequence analysis revealed were, in both poliovirus- and rhinovirus-derived viruses, located in the active-site cleft of 3D polymerase and involved the substitution of Asn18 for Tyr. These results provide further evidence of a specific interaction between the 3' UTR of picornaviruses and the viral polymerase and also indicate similar interactions of the 3' UTR of rhinovirus with both poliovirus and rhinovirus polymerases.

  1. Observational analysis of the atmosphere-land surface interactions over the TERENO pre-alpine region

    Science.gov (United States)

    Soltani, Mohsen; Mauder, Matthias; Laux, Patrick; Kunstmann, Harald

    2016-04-01

    In order to examine the variability of heat fluxes and energy partitioning over complex terrain in the TERrestrial ENvironmental Observatories (TERENO) pre-alpine region, the turbulent heat fluxes and moisture at the surface layer were calculated using the eddy covariance technique. To better understand the principle characteristics of the land-surface energy balance, monthly and seasonal variations of radiation components, heat fluxes and moisture contents in the region, the measurements obtained from three eddy-covariance towers from January 2013 to December 2014 were analyzed. The diurnal, monthly and seasonal variations observed in all the radiation components as a result of the seasonal variation in the solar radiation. The diurnal variations in shortwave radiation were larger than those of longwave radiations. The highest daily value of incoming shortwave radiation (ISR, 344.2 W/m2), incoming longwave radiation (ILR, 389.3 W/m2) and outgoing longwave radiation (OLR, 439.2 W/m2) were measured in summer, while the highest daily value of outgoing shortwave radiation (OSR, 120.7 W/m2) occurred in winter due to the snow cover in the region. The ISR and OLR had the strongest seasonal and interannual variability, in particular during the summertime. The maximum (extreme) surface albedo value was measured in winter 2013 due to the heavy snowfall event. By contrast, it was lower during the warm seasons because of a darker surface (i.e. high vegetation fraction and wetter soil). The seasonal variation of the sensible heat flux (H) was stronger than that of the latent heat flux (LE) in winter, while LE had a stronger variation in summer and considered as the main consumer of available energy in summer, while the soil heat flux (G) indicated the least variation over the experimental time. In addition, the range of the seasonal diurnal cycle of net radiation (Rn) increased from winter to summer and decreased in-turned position indicating a high variation of Rn in summer

  2. Aging and Osteoarthritis: An Inevitable Encounter?

    Directory of Open Access Journals (Sweden)

    Thomas Hügle

    2012-01-01

    Full Text Available Osteoarthritis (OA is a major health burden of our time. Age is the most prominent risk factor for the development and progression of OA. The mechanistic influence of aging on OA has different facets. On a molecular level, matrix proteins such as collagen or proteoglycans are modified, which alters cartilage function. Collagen cross-linking within the bone results in impaired plasticity and increased stiffness. Synovial or fat tissue, menisci but also ligaments and muscles play an important role in the pathogenesis of OA. In the elderly, sarcopenia or other causes of muscle atrophy are frequently encountered, leading to a decreased stability of the joint. Inflammation in form of cellular infiltration of synovial tissue or subchondral bone and expression of inflammatory cytokines is more and more recognized as trigger of OA. It has been demonstrated that joint movement can exhibit anti-inflammatory mechanisms. Therefore physical activity or physiotherapy in the elderly should be encouraged, also in order to increase the muscle mass. A reduced stem cell capacity in the elderly is likely associated with a decrease of repair mechanisms of the musculoskeletal system. New treatment strategies, for example with mesenchymal stem cells (MSC are investigated, despite clear evidence for their efficacy is lacking.

  3. LHC experiences close encounters with UFOs

    CERN Multimedia

    Mike Lamont for the LHC Team

    2011-01-01

    On 29 May, yet another record was set as 1092 bunches per beam were injected into the LHC, hitting a peak luminosity of 1.26x1033 cm-2 s-1. While running at 3.5 TeV each beam now packs a total energy of over 70 MJ – equivalent to a TGV travelling at a 70 kph.   Operators in the LHC Control Centre happily show off their display screens after succesfully injecting 1092 bunches injected into the machine for the first time.  As the total beam intensity has been pushed up, the LHC has encountered a number of related problems, such as the so-called UFOs (Unidentified Falling Objects). These are thought to be dust particles falling through the beam, causing localized beam loss. The losses can push nearby beam loss monitors over the threshold and dump the beam. This is more of an annoyance than a danger for the LHC, but UFOs do reduce the operational efficiency of the machine. Despite this, the luminosity delivered to the experiments has steadily increased. On three occasions there ha...

  4. Close encounters of the prototype kind

    CERN Multimedia

    2005-01-01

    CERN is building a new control centre for the operation of its entire accelerator complex and technical infrastructure. The prototype console for the new centre has just been installed and tested. Close encounters of the prototype kind CERN is building a new control centre for the operation of its entire accelerator complex and technical infrastructure. The prototype console for the new centre has just been installed and tested. The prototype of the control consoles that will be at the heart of the future CERN Control Centre (CCC) has just been installed in the Roy Billinge Room in Building 354. Until now, there have been four separate control rooms for the CERN accelerators and technical infrastructure. The CCC, which will be located on the Prévessin site, will bring them all together in a single room. The Centre will consist of 40 consoles for four different areas (LHC, SPS, PS complex and technical infrastructure). The prototype was tested by the technicians for a month. Following installation and con...

  5. Assortment of encounters and evolution of cooperativeness.

    Science.gov (United States)

    Eshel, I; Cavalli-Sforza, L L

    1982-02-01

    The method of evolutionary stable strategies (ESS), in its current form, is confronted with a difficulty when it tries to explain how some social behaviors initiate their evolution. We show that this difficulty may be removed by changing the assumption made tacitly in game theory (and in ESS) of randomness of meetings or encounters. In reality, such randomness seems to be rare in nature. Family, population and social structure, customs, and habits impose various types of deviation from randomness. Introducing nonrandomness of meeting in a way formally similar to assortative mating, we show that the bar to initial increase of inherited cooperative or altruistic behaviors can be removed, provided there is sufficient assortment of meetings. Family structure may cause contacts predominantly between certain types of relatives, and one can reconstruct some results of classical kin selection in terms of evolutionary stable strategy with assortative meetings. Neighbor effects and group selection might be similarly treated. Assortment need not be a passive consequence of population and social structure, but it can also be actively pursued. Behaviors favoring the choice of cooperative companions will have the effect of favoring the evolution of cooperativeness. It can be shown that discrimination in the choice of companions, especially if combined with assortment, can favor the development of cooperativeness, making initial increase of cooperative behavior possible even at levels of assortment passively imposed which would not be adequate, per se, to guarantee the increase of cooperativeness. It is possible that, in some cases, cooperativeness and behavior favoring some type of assortment are coselected.

  6. Incorporating Hypnosis into Pediatric Clinical Encounters.

    Science.gov (United States)

    Pendergrast, Robert A

    2017-03-16

    Increasing numbers of licensed health professionals who care for children have been trained in clinical hypnosis. The evidence base for the safety and efficacy of this therapeutic approach in a wide variety of conditions is also growing. Pediatricians and other health professionals who have received training may wish to apply these skills in appropriate clinical scenarios but still may be unsure of the practical matters of how to incorporate this skill-set into day to day practice. Moreover, the practical application of such skills will take very different forms depending on the practice setting, types of acute or chronic conditions, patient and family preferences, and the developmental stages of the child or teen. This article reviews the application of pediatric clinical hypnosis skills by describing the use of hypnotic language outside of formal trance induction, by describing natural trance states that occur in children and teens in healthcare settings, and by describing the process of planning a clinical hypnosis encounter. It is assumed that this article does not constitute training in hypnosis or qualify its readers for the application of such skills; rather, it may serve as a practical guide for those professionals who have been so trained, and may serve to inform other professionals what to expect when referring a patient for hypnotherapy. The reader is referred to specific training opportunities and organizations.

  7. Incorporating Hypnosis into Pediatric Clinical Encounters

    Directory of Open Access Journals (Sweden)

    Robert A. Pendergrast

    2017-03-01

    Full Text Available Increasing numbers of licensed health professionals who care for children have been trained in clinical hypnosis. The evidence base for the safety and efficacy of this therapeutic approach in a wide variety of conditions is also growing. Pediatricians and other health professionals who have received training may wish to apply these skills in appropriate clinical scenarios but still may be unsure of the practical matters of how to incorporate this skill-set into day to day practice. Moreover, the practical application of such skills will take very different forms depending on the practice setting, types of acute or chronic conditions, patient and family preferences, and the developmental stages of the child or teen. This article reviews the application of pediatric clinical hypnosis skills by describing the use of hypnotic language outside of formal trance induction, by describing natural trance states that occur in children and teens in healthcare settings, and by describing the process of planning a clinical hypnosis encounter. It is assumed that this article does not constitute training in hypnosis or qualify its readers for the application of such skills; rather, it may serve as a practical guide for those professionals who have been so trained, and may serve to inform other professionals what to expect when referring a patient for hypnotherapy. The reader is referred to specific training opportunities and organizations.

  8. Aerosol-cloud-precipitation interactions: A challenging problem in regional environment and climate research

    Institute of Scientific and Technical Information of China (English)

    P.C.S.Devara; M.G.Manoj

    2013-01-01

    Aerosols affect clouds in two broad ways:(i) presence of more number of aerosols leads to formation of more smaller droplets,and reduces coalescence,resulting in brighter clouds that reflect more solar energy back to space,hence they contribute to cooling of the Earth's surface and (ii) numerous smaller cloud droplets tend to reduce precipitation and change the extent of cloud cover and increase cloud lifetime and albedo.One of our recent studies on aerosols over the Indo-Gangetic Plains (IGP) relative to the pristine oceans to the south of Indian Ocean showed that highly absorbing aerosols could potentially lead to the revival of active condition preceded by long break.The absorption of solar radiation by aerosols such as black carbon and desert dust produces surface cooling and local stabilization of lower atmosphere.This stability effect is overcome by the enhanced moisture convergence due to the meridional gradient of aerosol-induced heating.In some other studies,we showed association between cloud thickness and cloud to sub-cloud ratio (SCR),aerosol variability (in terms of aerosol optical depth and aerosol index) and monsoon precipitation and climate over regional scale.This paper provides an overview of some salient results that have been obtained from the studies conducted,using the ground-and space-based active and passive remote sensing techniques,at the Indian Institute of Tropical Meteorology (IITM),Pune,India in the recent decade.

  9. INTERACT

    DEFF Research Database (Denmark)

    Jochum, Elizabeth; Borggreen, Gunhild; Murphey, TD

    This paper considers the impact of visual art and performance on robotics and human-computer interaction and outlines a research project that combines puppetry and live performance with robotics. Kinesics—communication through movement—is the foundation of many theatre and performance traditions...... interaction between a human operator and an artificial actor or agent. We can apply insights from puppetry to develop culturally-aware robots. Here we describe the development of a robotic marionette theatre wherein robotic controllers assume the role of human puppeteers. The system has been built, tested...

  10. First Encounters: Knowledge Interpretation on the Front-Lines of Cross-Cultural Encounters

    Directory of Open Access Journals (Sweden)

    Robert F. Barsky

    2012-06-01

    Full Text Available The hypothesis that guides this work is that although it may be valuable to lobby for competent translators to help vulnerable foreigners in cross-cultural settings, such as the Canadian Convention refugee determination hearings or criminal trials, it is nevertheless too late to make much of a difference at that point, because most of the incriminating damage is done in the initial encounter between claimant/defendant and authority. Approaching a discussion about the relative merits of translation versus interpretation from this perspective, that emphasizes the time at which the conversation occurs, would suggest that linguistic accuracy is much more important in formal hearings, while interpretation is crucial during the initial encounter, because it is during this period of negotiation that a sensitive and qualified interpreter can keep a claimant from incriminating herself or mis-communicating the situation to authority.

  11. Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

    Energy Technology Data Exchange (ETDEWEB)

    Pancera, Marie; Majeed, Shahzad; Ban, Yih-En Andrew; Chen, Lei; Huang, Chih-chin; Kong, Leopold; Kwon, Young Do; Stuckey, Jonathan; Zhou, Tongqing; Robinson, James E.; Schief, William R.; Sodroski, Joseph; Wyatt, Richard; Kwong, Peter D. (UWASH); (NIH); (Tulane); (DFCI)

    2010-04-15

    The viral spike of HIV-1 is composed of three gp120 envelope glycoproteins attached noncovalently to three gp41 transmembrane molecules. Viral entry is initiated by binding to the CD4 receptor on the cell surface, which induces large conformational changes in gp120. These changes not only provide a model for receptor-triggered entry, but affect spike sensitivity to drug- and antibody-mediated neutralization. Although some of the details of the CD4-induced conformational change have been visualized by crystal structures and cryoelectron tomograms, the critical gp41-interactive region of gp120 was missing from previous atomic-level characterizations. Here we determine the crystal structure of an HIV-1 gp120 core with intact gp41-interactive region in its CD4-bound state, compare this structure to unliganded and antibody-bound forms to identify structurally invariant and plastic components, and use ligand-oriented cryoelectron tomograms to define component mobility in the viral spike context. Newly defined gp120 elements proximal to the gp41 interface complete a 7-stranded {beta}-sandwich, which appeared invariant in conformation. Loop excursions emanating from the sandwich form three topologically separate - and structurally plastic - layers, topped off by the highly glycosylated gp120 outer domain. Crystal structures, cryoelectron tomograms, and interlayer chemistry were consistent with a mechanism in which the layers act as a shape-changing spacer, facilitating movement between outer domain and gp41-associated {beta}-sandwich and providing for conformational diversity used in immune evasion. A 'layered' gp120 architecture thus allows movement among alternative glycoprotein conformations required for virus entry and immune evasion, whereas a {beta}-sandwich clamp maintains gp120-gp41 interaction and regulates gp41 transitions.

  12. A Spatially Explicit Dual-Isotope Approach to Map Regions of Plant-Plant Interaction after Exotic Plant Invasion.

    Directory of Open Access Journals (Sweden)

    Christine Hellmann

    Full Text Available Understanding interactions between native and invasive plant species in field settings and quantifying the impact of invaders in heterogeneous native ecosystems requires resolving the spatial scale on which these processes take place. Therefore, functional tracers are needed that enable resolving the alterations induced by exotic plant invasion in contrast to natural variation in a spatially explicit way. 15N isoscapes, i.e., spatially referenced representations of stable nitrogen isotopic signatures, have recently provided such a tracer. However, different processes, e.g. water, nitrogen or carbon cycles, may be affected at different spatial scales. Thus multi-isotope studies, by using different functional tracers, can potentially return a more integrated picture of invader impact. This is particularly true when isoscapes are submitted to statistical methods suitable to find homogeneous subgroups in multivariate data such as cluster analysis. Here, we used model-based clustering of spatially explicit foliar δ15N and δ13C isoscapes together with N concentration of a native indicator species, Corema album, to map regions of influence in a Portuguese dune ecosystem invaded by the N2-fixing Acacia longifolia. Cluster analysis identified regions with pronounced alterations in N budget and water use efficiency in the native species, with a more than twofold increase in foliar N, and δ13C and δ15N enrichment of up to 2‰ and 8‰ closer to the invader, respectively. Furthermore, clusters of multiple functional tracers indicated a spatial shift from facilitation through N addition in the proximity of the invader to competition for resources other than N in close contact. Finding homogeneous subgroups in multi-isotope data by means of model-based cluster analysis provided an effective tool for detecting spatial structure in processes affecting plant physiology and performance. The proposed method can give an objective measure of the spatial extent

  13. Sustained spatial attention to vibrotactile stimulation in the flutter range: relevant brain regions and their interaction.

    Science.gov (United States)

    Goltz, Dominique; Pleger, Burkhard; Thiel, Sabrina D; Thiel, Sabrina; Villringer, Arno; Müller, Matthias M

    2013-01-01

    The present functional magnetic resonance imaging (fMRI) study was designed to get a better understanding of the brain regions involved in sustained spatial attention to tactile events and to ascertain to what extent their activation was correlated. We presented continuous 20 Hz vibrotactile stimuli (range of flutter) concurrently to the left and right index fingers of healthy human volunteers. An arrow cue instructed subjects in a trial-by-trial fashion to attend to the left or right index finger and to detect rare target events that were embedded in the vibrotactile stimulation streams. We found blood oxygen level-dependent (BOLD) attentional modulation in primary somatosensory cortex (SI), mainly covering Brodmann area 1, 2, and 3b, as well as in secondary somatosensory cortex (SII), contralateral to the to-be-attended hand. Furthermore, attention to the right (dominant) hand resulted in additional BOLD modulation in left posterior insula. All of the effects were caused by an increased activation when attention was paid to the contralateral hand, except for the effects in left SI and insula. In left SI, the effect was related to a mixture of both a slight increase in activation when attention was paid to the contralateral hand as well as a slight decrease in activation when attention was paid to the ipsilateral hand (i.e., the tactile distraction condition). In contrast, the effect in left posterior insula was exclusively driven by a relative decrease in activation in the tactile distraction condition, which points to an active inhibition when tactile information is irrelevant. Finally, correlation analyses indicate a linear relationship between attention effects in intrahemispheric somatosensory cortices, since attentional modulation in SI and SII were interrelated within one hemisphere but not across hemispheres. All in all, our results provide a basis for future research on sustained attention to continuous vibrotactile stimulation in the range of flutter.

  14. Sustained spatial attention to vibrotactile stimulation in the flutter range: relevant brain regions and their interaction.

    Directory of Open Access Journals (Sweden)

    Dominique Goltz

    Full Text Available The present functional magnetic resonance imaging (fMRI study was designed to get a better understanding of the brain regions involved in sustained spatial attention to tactile events and to ascertain to what extent their activation was correlated. We presented continuous 20 Hz vibrotactile stimuli (range of flutter concurrently to the left and right index fingers of healthy human volunteers. An arrow cue instructed subjects in a trial-by-trial fashion to attend to the left or right index finger and to detect rare target events that were embedded in the vibrotactile stimulation streams. We found blood oxygen level-dependent (BOLD attentional modulation in primary somatosensory cortex (SI, mainly covering Brodmann area 1, 2, and 3b, as well as in secondary somatosensory cortex (SII, contralateral to the to-be-attended hand. Furthermore, attention to the right (dominant hand resulted in additional BOLD modulation in left posterior insula. All of the effects were caused by an increased activation when attention was paid to the contralateral hand, except for the effects in left SI and insula. In left SI, the effect was related to a mixture of both a slight increase in activation when attention was paid to the contralateral hand as well as a slight decrease in activation when attention was paid to the ipsilateral hand (i.e., the tactile distraction condition. In contrast, the effect in left posterior insula was exclusively driven by a relative decrease in activation in the tactile distraction condition, which points to an active inhibition when tactile information is irrelevant. Finally, correlation analyses indicate a linear relationship between attention effects in intrahemispheric somatosensory cortices, since attentional modulation in SI and SII were interrelated within one hemisphere but not across hemispheres. All in all, our results provide a basis for future research on sustained attention to continuous vibrotactile stimulation in the range

  15. Functional interaction of CCAAT/enhancer-binding-protein-α basic region mutants with E2F transcription factors and DNA.

    Science.gov (United States)

    Kowenz-Leutz, Elisabeth; Schuetz, Anja; Liu, Qingbin; Knoblich, Maria; Heinemann, Udo; Leutz, Achim

    2016-07-01

    The transcription factor CCAAT/enhancer-binding protein α (C/EBPα) regulates cell cycle arrest and terminal differentiation of neutrophils and adipocytes. Mutations in the basic leucine zipper domain (bZip) of C/EBPα are associated with acute myeloid leukemia. A widely used murine transforming C/EBPα basic region mutant (BRM2) entails two bZip point mutations (I294A/R297A). BRM2 has been discordantly described as defective for DNA binding or defective for interaction with E2F. We have separated the two BRM2 mutations to shed light on the intertwined reciprocity between C/EBPα-E2F-DNA interactions. Both, C/EBPα I294A and R297A retain transactivation capacity and interaction with E2F-DP. The C/EBPα R297A mutation destabilized DNA binding, whereas the C/EBPα I294A mutation enhanced binding to DNA. The C/EBPα R297A mutant, like BRM2, displayed enhanced interaction with E2F-DP but failed to repress E2F-dependent transactivation although both mutants were readily suppressed by E2F1 for transcription through C/EBP cis-regulatory sites. In contrast, the DNA binding enhanced C/EBPα I294A mutant displayed increased repression of E2F-DP mediated transactivation and resisted E2F-DP mediated repression. Thus, the efficient repression of E2F dependent S-phase genes and the activation of differentiation genes reside in the balanced DNA binding capacity of C/EBPα.

  16. Principal coordinate analysis of genotype × environment interaction for grain yield of bread wheat in the semi-arid regions

    Directory of Open Access Journals (Sweden)

    Sabaghnia Naser

    2013-01-01

    Full Text Available Multi-environmental trials have significant main effects and significant multiplicative genotype × environment (GE interaction effect. Principal coordinate analysis (PCOA offers a more appropriate statistical analysis to deal with such situations, compared to traditional statistical methods. Eighteen bread wheat genotypes were grown in four semi-arid regions over three year seasons to study the GE interaction and yield stability and obtained data on grain yield were analyzed using PCOA. Combined analysis of variance indicated that all of the studied effects including the main effects of genotype and environments as well as the GE interaction were highly significant. According to grand means and total mean yield, test environments were grouped to two main groups as high mean yield (H and low mean yield (L. There were five H test environments and six L test environments which analyzed in the sequential cycles. For each cycle, both scatter point diagram and minimum spanning tree plot were drawn. The identified most stable genotypes with dynamic stability concept and based on the minimum spanning tree plots and centroid distances were G1 (3310.2 kg ha-1 and G5 (3065.6 kg ha-1, and therefore could be recommended for unfavorable or poor conditions. Also, genotypes G7 (3047.2 kg ha-1 and G16 (3132.3 kg ha-1 were located several times in the vertex positions of high cycles according to the principal coordinates analysis. The principal coordinates analysis provided useful and interesting ways of investigating GE interaction of barley genotypes. Finally, the results of principal coordinates analysis in general confirmed the breeding value of the genotypes, obtained on the basis of the yield stability evaluation.

  17. Close Encounters of Lymphoid Cells and Bacteria

    Science.gov (United States)

    Cruz-Adalia, Aranzazu; Veiga, Esteban

    2016-01-01

    During infections, the first reaction of the host against microbial pathogens is carried out by innate immune cells, which recognize conserved structures on pathogens, called pathogen-associated molecular patterns. Afterward, some of these innate cells can phagocytose and destroy the pathogens, secreting cytokines that would modulate the immune response to the challenge. This rapid response is normally followed by the adaptive immunity, more specific and essential for a complete pathogen clearance in many cases. Some innate immune cells, usually named antigen-presenting cells, such as macrophages or dendritic cells, are able to process internalized invaders and present their antigens to lymphocytes, triggering the adaptive immune response. Nevertheless, the traditional boundary of separated roles between innate and adaptive immunity has been blurred by several studies, showing that very specialized populations of lymphocytes (cells of the adaptive immunity) behave similarly to cells of the innate immunity. These “innate-like” lymphocytes include γδ T cells, invariant NKT cells, B-1 cells, mucosal-associated invariant T cells, marginal zone B cells, and innate response activator cells, and together with the newly described innate lymphoid cells are able to rapidly respond to bacterial infections. Strikingly, our recent data suggest that conventional CD4+ T cells, the paradigm of cells of the adaptive immunity, also present innate-like behavior, capturing bacteria in a process called transinfection. Transinfected CD4+ T cells digest internalized bacteria like professional phagocytes and secrete large amounts of proinflammatory cytokines, protecting for further bacterial challenges. In the present review, we will focus on the data showing such innate-like behavior of lymphocytes following bacteria encounter.

  18. Opening stages in triadic medical encounters in Taiwan.

    Science.gov (United States)

    Tsai, Mei-Hui

    2005-01-01

    Opening stages in medical interviews are important because good doctor-patient rapport facilitates the doctor's tasks in later stages, especially in triadic first-visit interviews where doctors are not acquaintances of patients and companions. Given its importance, the research examines opening stages in the Taiwanese context from two perspectives: discourse components of opening stages and discourse mechanisms of presenting non-acquaintances' identities, especially the companions' identities. By examining 30 geriatric triadic encounters collected in a teaching hospital in southern Taiwan, this research concludes that opening-stage interaction patterns in Taiwanese medical interviews differ from Western patterns in the following ways. Under time pressure, Taiwanese doctors tend to open the interview in a fast pattern that hardly allows verbal participation from the patients. The common practice of presenting non-acquaintances' identities in Western conversation openings is rarely observed in the Taiwanese context. As a result, contrary to the professional norms, most companions' identities are not clarified until they talk in the later stages, such as the pedigree stage, which is the most natural context for revealing their identities. This seeming violation of professional norms, however, can be explained by traditional Chinese interaction norms, and can be remedied by following another traditional norm-using a situational greeting. Further recommendations for Taiwanese medical professionals are also proposed to balance these potentially conflicting needs.

  19. RGS12 interacts with the SNARE-binding region of the Cav2.2 calcium channel.

    Science.gov (United States)

    Richman, Ryan W; Strock, Jesse; Hains, Melinda D; Cabanilla, Nory Jun; Lau, King-Kei; Siderovski, David P; Diversé-Pierluissi, María

    2005-01-14

    Activation of GABAB receptors in chick dorsal root ganglion (DRG) neurons inhibits the Cav2.2 calcium channel in both a voltage-dependent and voltage-independent manner. The voltage-independent inhibition requires activation of a tyrosine kinase that phosphorylates the alpha1 subunit of the channel and thereby recruits RGS12, a member of the "regulator of G protein signaling" (RGS) proteins. Here we report that RGS12 binds to the SNARE-binding or "synprint" region (amino acids 726-985) in loop II-III of the calcium channel alpha1 subunit. A recombinant protein encompassing the N-terminal PTB domain of RGS12 binds to the synprint region in protein overlay and surface plasmon resonance binding assays; this interaction is dependent on tyrosine phosphorylation and yet is within a sequence that differs from the canonical NPXY motif targeted by other PTB domains. In electrophysiological experiments, microinjection of DRG neurons with synprint-derived peptides containing the tyrosine residue Tyr-804 altered the rate of desensitization of neurotransmitter-mediated inhibition of the Cav2.2 calcium channel, whereas peptides centered about a second tyrosine residue, Tyr-815, were without effect. RGS12 from a DRG neuron lysate was precipitated using synprint peptides containing phosphorylated Tyr-804. The high degree of conservation of Tyr-804 in the SNARE-binding region of Cav2.1 and Cav2.2 calcium channels suggests that this region, in addition to the binding of SNARE proteins, is also important for determining the time course of the modulation of calcium current via tyrosine phosphorylation.

  20. Moving beyond the language barrier: the communication strategies used by international medical graduates in intercultural medical encounters.

    Science.gov (United States)

    Jain, Parul; Krieger, Janice L

    2011-07-01

    To understand the communication strategies international medical graduates use in medical interactions to overcome language and cultural barriers. In-depth interviews were conducted with 12 international physicians completing their residency training in internal medicine in a large hospital in Midwestern Ohio. The interview explored (a) barriers participants encountered while communicating with their patients regarding language, affect, and culture, and (b) communication convergence strategies used to make the interaction meaningful. International physicians use multiple convergence strategies when interacting with their patients to account for the intercultural and intergroup differences, including repeating information, changing speaking styles, and using non-verbal communication. Understanding barriers to communication faced by international physicians and recognizing accommodation strategies they employ in the interaction could help in training of future international doctors who come to the U.S. to practice medicine. Early intervention could reduce the time international physicians spend navigating through the system and trying to learn by experimenting with different strategies which will allow these physicians to devote more time to patient care. We recommend developing a training manual that is instructive of the socio-cultural practices of the region where international physician will start practicing medicine. Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.

  1. Serotonin Transporter-Linked Polymorphic Region (5-HTTLPR) Genotype and Stressful Life Events Interact to Predict Preschool-Onset Depression: A Replication and Developmental Extension

    Science.gov (United States)

    Bogdan, Ryan; Agrawal, Arpana; Gaffrey, Michael S.; Tillman, Rebecca; Luby, Joan L.

    2014-01-01

    Background: Scientific enthusiasm about gene × environment interactions, spurred by the 5-HTTLPR (serotonin transporter-linked polymorphic region) × SLEs (stressful life events) interaction predicting depression, have recently been tempered by sober realizations of small effects and meta-analyses reaching opposing conclusions. These mixed findings…

  2. Early life adversity and serotonin transporter gene variation interact to affect DNA methylation of the corticotropin-releasing factor gene promoter region in the adult rat brain

    NARCIS (Netherlands)

    Doelen, R.H. van der; Arnoldussen, I.A.C.; Ghareh, H.; Och, L. van; Homberg, J.R.; Kozicz, L.T.

    2015-01-01

    The interaction between childhood maltreatment and the serotonin transporter (5-HTT) gene linked polymorphic region has been associated with increased risk to develop major depression. This Gene x Environment interaction has furthermore been linked with increased levels of anxiety and glucocorticoid

  3. Encountering My Privilege (and Others' Oppression)

    Science.gov (United States)

    Kirby, Erika L.

    2016-01-01

    Courses: Communication and Diversity, Intercultural Communication, Gender Communication. Objectives: After completing this semester-long activity, students should be able to (1) articulate a systems-of-oppression (privilege??oppression) approach to thinking about difference; (2) confront and "interact differently" with one social…

  4. The difficult encounter between inspector and farmer

    DEFF Research Database (Denmark)

    Anneberg, Inger; Sørensen, Jan Tind; Vaarst, Mette

    2012-01-01

    When the inspector drives into the farmyard and asks to see the animal barns to inspect the welfare of the animals, a tense situation may arise because inspections transcend limits and are complex and difficult for many farmers to relate to. A new research project is examining the interaction...... between authorities and farmers....

  5. Beyond the interface: Encountering artifacts in use

    DEFF Research Database (Denmark)

    Bødker, Susanne; Bannon, Liam

    1991-01-01

    This paper is written by two people who come form rather different backgrounds, yet who, at the same time, share similar concerns about the human-computer interaction (HCI) area. One of us has a background in computing and cognitive science, coupled with a long-standing interest in helping users ...

  6. Interactive Development-oriented Poverty Reduction Model for Bijie Experimental Region under the Guidance of Scientific Outlook on Development

    Institute of Scientific and Technical Information of China (English)

    Faliang; YU; Lisong; CHEN

    2013-01-01

    Bijie Experimental Region takes the ecological construction as the guarantee and takes population control as the key,to promote development-oriented poverty reduction and explore benign interaction between development-oriented poverty reduction and ecological construction and population control.Development-oriented poverty reduction model includes combination of raising crops and livestock,coordinated development of multiple wealth sources,transferring labor,and partner assistance;ecological construction model includes"Five sons passed imperial examinations",desertification control,agricultural circular economy,and project promotion;population control models includes human-land linkage,combination of favorable policies and propaganda and education,and combination of ambition arousing and education promotion.

  7. Integration of Soil Information System and Interactive Self—Organizing Data for Agricultural Developing Zones in Red Soil Region

    Institute of Scientific and Technical Information of China (English)

    SHIZHOU; WANGRENCHAO; 等

    1999-01-01

    Integration of soil information system (SIS) and interactive self-organizing data(ISODATA) was studied to establish proper agricultural developing zones in red soil region of southern China which are of crucial importance to farmers,researchers,and decision maders while utilizing and managing red soil resources.SIS created by using ARC/INFO was used to provide data acquisition,systematic model parameter assignment,and visual display of analytic results.Topography,temperature,soil component(e.g.,organic matter and pH) and condition of agricultural production were selected as parameters of ISODATA model.Taking Longyou County,Zhejiang Province as the case study area,the effect of the integration and recommendations are discussed for future research.

  8. Numerical simulations of land surface physical processes and land-atmosphere interactions over oasis-desert/Gobi region

    Institute of Scientific and Technical Information of China (English)

    LIU ShuHua; LIU HePing; HU Yu; ZHANG ChengYi; LIANG FuMing; WANG JianHua

    2007-01-01

    A land-surface physical process model was coupled with a mesoscale atmospheric model. This coupled model was then used to simulate the interactions between land and the atmosphere, including surface temperature, net radiation, sensible heat flux and latent heat flux over a desert/Gobi with an oasis in northwestern semiarid regions in China. Comparisons between observations and simulations were made over the oasis and the desert/Gobi, respectively. Both cold island effect and wet island effect, the so-called oasis effect, were observed and simulated. Lower temperature, higher specific humidity and weaker turbulent transfer were present over the oasis than the desert/Gobi. A subsidence occurred over the oasis, leading to a thermally-generated mesoscale circulation.

  9. The Value of Difference: Kantian Hospitality and Flikschuh’s Rethinking of Nomadic Encounters

    Directory of Open Access Journals (Sweden)

    Suma Rajiva

    2017-06-01

    Full Text Available In this essay I discuss the issue of Kantian hospitality and how Katrin Flikschuh’s arguments in “Kant’s Nomads: Encountering Strangers” offer us a framework for dealing with certain problems that seem to arise out of the Kantian account, namely, problems of dealing with cultures unlike modern liberal states, such as nomadic and indigenous communities. I look at some criticisms of Kant’s position on hospitality and cosmopolitan right and on how Flikschuh’s discussion helps to resolve these criticisms. I focus especially on her discussion of respectful interaction and openness in the course of encountering cultural others, encounters that inherently and positively contain a large element of unexpectedness.

  10. The Influence of Everyday Interpersonal Communication on the Medical Encounter: An Extension of Street's Ecological Model.

    Science.gov (United States)

    Head, Katharine J; Bute, Jennifer J

    2017-04-13

    Street's ecological model has shaped the research-examining communication during medical encounters for over a decade. Although the model accounts for the variety of contexts that shape the conversations in which patients and health-care providers engage, the model does not adequately address the way that everyday conversations about health carry over into patient-provider interactions. In this essay, we propose an extension of Street's model that adds the context of everyday communication about health as a contributing factor in the medical encounter. We support the need for this extension by discussing research that points to the ways these conversations with our social network influence communication during the medical encounter and propose new areas for research based on this extension.

  11. PROTECT: Proximity-based Trust-advisor using Encounters for Mobile Societies

    CERN Document Server

    Kumar, Udayan; Helmy, Ahmed

    2010-01-01

    Many interactions between network users rely on trust, which is becoming particularly important given the security breaches in the Internet today. These problems are further exacerbated by the dynamics in wireless mobile networks. In this paper we address the issue of trust advisory and establishment in mobile networks, with application to ad hoc networks, including DTNs. We utilize encounters in mobile societies in novel ways, noticing that mobility provides opportunities to build proximity, location and similarity based trust. Four new trust advisor filters are introduced - including encounter frequency, duration, behavior vectors and behavior matrices - and evaluated over an extensive set of real-world traces collected from a major university. Two sets of statistical analyses are performed; the first examines the underlying encounter relationships in mobile societies, and the second evaluates DTN routing in mobile peer-to-peer networks using trust and selfishness models. We find that for the analyzed trace...

  12. Interaction of a nodule specific, trans-acting factor with distinct DNA elements in the soybean leghaemoglobin Ibc(3) 5' upstream region

    DEFF Research Database (Denmark)

    Jensen, Erik Østergaard; Marcker, Kjeld A; Schell, J;

    1988-01-01

    Nuclear extracts from soybean nodules, leaves and roots were used to investigate protein-DNA interactions in the 5' upstream (promoter) region of the soybean leghaemoglobin lbc(3) gene. Two distinct regions were identified which strongly bind a nodule specific factor. A Bal31 deletion analysis de...

  13. UNCOVERING THE DEEPLY EMBEDDED ACTIVE GALACTIC NUCLEUS ACTIVITY IN THE NUCLEAR REGIONS OF THE INTERACTING GALAXY Arp 299

    Energy Technology Data Exchange (ETDEWEB)

    Alonso-Herrero, A. [Instituto de Física de Cantabria, CSIC-UC, E-39005 Santander (Spain); Roche, P. F. [Astrophysics Department, University of Oxford, Oxford OX1 3RH (United Kingdom); Esquej, P.; Colina, L. [Centro de Astrobiología, CSIC-INTA, E-28035 Madrid (Spain); González-Martín, O.; Ramos Almeida, C.; Asensio Ramos, A.; Rodríguez Espinosa, J. M.; Alvarez, C. [Instituto de Astrofísica de Canarias, E-38205 La Laguna (Spain); Pereira-Santaella, M. [Istituto di Astrofisica e Planetologia Spaziali, INAF, I-00133 Rome (Italy); Levenson, N. A. [Gemini Observatory, La Serena (Chile); Packham, C. [University of Texas at San Antonio, San Antonio, TX 78249 (United States); Mason, R. E. [Gemini Observatory, Hilo, HI 96720 (United States); Aretxaga, I. [INAOE, 72000 Puebla (Mexico); Díaz-Santos, T. [Spitzer Science Center, Caltech, Pasadena, CA 91125 (United States); Perlman, E. [Florida Institute of Technology, Melbourne, FL 32901 (United States); Telesco, C. M., E-mail: aalonso@ifca.unican.es [Department of Astronomy, University of Florida, Gainesville, FL 32611 (United States)

    2013-12-10

    We present mid-infrared (MIR) 8-13 μm spectroscopy of the nuclear regions of the interacting galaxy Arp 299 (IC 694+NGC 3690) obtained with CanariCam (CC) on the 10.4 m Gran Telescopio Canarias (GTC). The high angular resolution (∼0.''3-0.''6) of the data allows us to probe nuclear physical scales between 60 and 120 pc, which is a factor of 10 improvement over previous MIR spectroscopic observations of this system. The GTC/CC spectroscopy displays evidence of deeply embedded active galactic nucleus (AGN) activity in both nuclei. The GTC/CC nuclear spectrum of NGC 3690/Arp 299-B1 can be explained as emission from AGN-heated dust in a clumpy torus with both a high covering factor and high extinction along the line of sight. The estimated bolometric luminosity of the AGN in NGC 3690 is 3.2 ± 0.6 × 10{sup 44} erg s{sup –1}. The nuclear GTC/CC spectrum of IC 694/Arp 299-A shows 11.3 μm polycyclic aromatic hydrocarbon emission stemming from a deeply embedded (A{sub V} ∼ 24 mag) region of less than 120 pc in size. There is also a continuum-emitting dust component. If associated with the putative AGN in IC 694, we estimate that it would be approximately five times less luminous than the AGN in NGC 3690. The presence of dual AGN activity makes Arp 299 a good example to study such phenomena in the early coalescence phase of interacting galaxies.

  14. Functional interactions within the parahippocampal region revealed by voltage-sensitive dye imaging in the isolated guinea pig brain.

    Science.gov (United States)

    Biella, Gerardo; Spaiardi, Paolo; Toselli, Mauro; de Curtis, Marco; Gnatkovsky, Vadym

    2010-02-01

    The massive transfer of information from the neocortex to the entorhinal cortex (and vice versa) is hindered by a powerful inhibitory control generated in the perirhinal cortex. In vivo and in vitro experiments performed in rodents and cats support this conclusion, further extended in the present study to the analysis of the interaction between the entorhinal cortex and other parahippocampal areas, such as the postrhinal and the retrosplenial cortices. The experiments were performed in the in vitro isolated guinea pig brain by a combined approach based on electrophysiological recordings and fast imaging of optical signals generated by voltage-sensitive dyes applied to the entire brain by arterial perfusion. Local stimuli delivered in different portions of the perirhinal, postrhinal, and retrosplenial cortex evoked local responses that did not propagate to the entorhinal cortex. Neither high- and low-frequency-patterned stimulation nor paired associative stimuli facilitated the propagation of activity to the entorhinal region. Similar stimulations performed during cholinergic neuromodulation with carbachol were also ineffective in overcoming the inhibitory network that controls propagation to the entorhinal cortex. The pharmacological inactivation of GABAergic transmission by local application of bicuculline (1 mM) in area 36 of the perirhinal cortex facilitated the longitudinal (rostrocaudal) propagation of activity into the perirhinal/postrhinal cortices but did not cause propagation into the entorhinal cortex. Bicuculline injection in both area 35 and medial entorhinal cortex released the inhibitory control and allowed the propagation of the neural activity to the entorhinal cortex. These results demonstrate that, as for the perirhinal-entorhinal reciprocal interactions, also the connections between the postrhinal/retrosplenial cortices and the entorhinal region are subject to a powerful inhibitory control.

  15. Visuality – Textuality: An Uncanny Encounter

    Directory of Open Access Journals (Sweden)

    Elisabeth Bronfen

    2010-08-01

    Full Text Available

     

    Abstract (E: Given that visuality is as much a part of all narration as the fact that we view images by reading them as though they were texts, this essay proposes to speak about an uncanny encounter between the two. In order to illustrate this mutual implication, as well as to bring in the theme of the spectral (that Freud suggests all experiences of the uncanny entail, it offers a cross-mapping between three different media at three different historical moments: a novella by the late Victorian author Charlotte Perkins Gilman, a series of photographs by the late modern photographer Francesca Woodman, and a film by the postmodern film maker Amenábar.

    Abstract (F:

     

    Cet article part de deux observations : à savoir que la visualité fait partie du champ plus large du récit, et que nous regardons les images en les lisant comme si elles étaient des textes. À partir de là, on examine la rencontre du textuel et du visuel comme une forme de l’inquiétante étrangeté. Afin d’illustrer leur implication réciproque et d’introduire la notion de spectre (dont Freud pose qu’il est sous-entendu par toutes les expériences de l’inquiétante étrangeté, l’article procède à l’analyse comparative de trois médias à trois moments historiques différents : un récit par une auteure des dernières années de l’ère victorienne, Charlotte Perkins Gilman ; une suite de photographes par la photographe du modernisme tardif Francesca Woodman ; et un film par le r

  16. Due Regard Encounter Model Version 1.0

    Science.gov (United States)

    2013-08-19

    Note that no existing model covers encoun- ters between two IFR aircraft in oceanic airspace. The reason for this is that one cannot observe encounters...encounters between instrument flight rules ( IFR ) and non- IFR traffic beyond 12NM. 2 TABLE 1 Encounter model categories. Aircraft of Interest Intruder...Aircraft Location Flight Rule IFR VFR Noncooperative Noncooperative Conventional Unconventional CONUS IFR C C U X VFR C U U X Offshore IFR C C U X VFR C U

  17. Interactions

    DEFF Research Database (Denmark)

    The main theme of this anthology is the unique interaction between mathematics, physics and philosophy during the beginning of the 20th century. Seminal theories of modern physics and new fundamental mathematical structures were discovered or formed in this period. Significant physicists...... such as Lorentz and Einstein as well as mathematicians such as Poincare, Minkowski, Hilbert and Weyl contributed to this development. They created the new physical theories and the mathematical disciplines that play such paramount roles in their mathematical formulations. These physicists and mathematicians were...

  18. Encountering whales: How encounter rates became the basis for managing whaling

    Directory of Open Access Journals (Sweden)

    Tim D Smith

    2009-09-01

    Full Text Available Declining rates of encountering whales, including both sighting and catching, were noted by whalers throughout the 19th century, and these declines became the first indication that whaling was adversely affecting whale abundance. The interpretation of declines in both sighting and catch rates proved to be a difficult scientific task. Satisfactory quantitative methods of interpreting changes in whale encounter rates were not developed until the second half of the 20th century. Rates of encountering whales played a key role in the International Whaling Commission (IWC Scientific Committee from its beginning in the early 1950s, as well as in the US in implementing its Marine Mammal Protection Act beginning in the early 1970s. The development of methods of collecting and interpreting sighting and catch data was intimately interwoven with the development of themanagement of whaling and cetacean by-catches in fisheries throughout the world, but especially within the context of the Scientific Committees of the IWC and the North Atlantic Marine Mammal Commission (NAMMCO. Although overfishing of whales was initially identified through the use of sighting rate data, catch rate data provided the IWC’s Committee its first firm footing for management advice. However, it was sighting rate data that ultimately became the basis for the scientific advice on whaling and for management advice in other settings. This led to the development of large scale cetacean sighting programmes, such as the IWC’s International Decade of Cetacean Researchsurveys in Antarctic aboard Japanese ships, the North Atlantic Sighting Surveys (NASS aboard Norwegian, Icelandic, Spanish, Greenlandic and Faroese vessels and aircraft (coordinated by NAMMCO through its Scientific Committee from 1995, and surveys under the US’s Marine Mammal Protection Act and the European Union’s Small Cetacean Abundance in the North Sea (SCANS programme. Fishery independent cetacean sighting surveys

  19. Development and manufacturing of a Nb$_{3}$Sn quadrupole magnet Model at CEA/Saclay for TESLA Interaction Region

    CERN Document Server

    Durante, Maria; Fratini, M; Leboeuf, D; Segreti, M; Védrine, Pierre; 10.1109/TASC.2004.829129

    2004-01-01

    One possible application of Nb/sub 3/Sn, whose superconducting properties far exceed those of NbTi, is the fabrication of short and powerful quadrupole magnets for the interaction regions of large particle accelerators. In some projects, as in the future linear collider TESLA, the quadrupole magnets are inside the detector solenoid and must operate in its background field. This situation gives singular Lorentz force distribution in the ends of the magnet. To learn about Nb/sub 3/Sn technology, evaluate fabrication techniques and test the interaction with a solenoidal field, DAPNIA /SACM at CEA/Saclay has started the manufacturing of a 1-m-long, 56- mm-single-aperture quadrupole magnet model. The model relies on the same coil geometry as the LHC arc quadrupole magnets, but has no iron yoke. It will produce a nominal field gradient of 211 T/m at 11,870 A. The coils are wound from Rutherford-type cables insulated with glass fiber tape, before being heat-treated and vacuum-impregnated with epoxy resin. Laminated,...

  20. Source Regions of the Type II Radio Burst Observed During a CME-CME Interaction on 2013 May 22

    CERN Document Server

    Gopalswamy, P Mäkelä N; Akiyama, S; Krupar, V

    2016-01-01

    We report on our study of radio source regions during the type II radio burst on 2013 May 22 based on direction finding (DF) analysis of the Wind/WAVES and STEREO/WAVES (SWAVES) radio observations at decameter-hectometric (DH) wavelengths. The type II emission showed an enhancement that coincided with interaction of two coronal mass ejections (CMEs) launched in sequence along closely spaced trajectories. The triangulation of the SWAVES source directions posited the ecliptic projections of the radio sources near the line connecting the Sun and the STEREO-A spacecraft. The WAVES and SWAVES source directions revealed shifts in the latitude of the radio source indicating that the spatial location of the dominant source of the type II emission varies during the CME-CME interaction. The WAVES source directions close to 1 MHz frequencies matched the location of the leading edge of the primary CME seen in the images of the LASCO/C3 coronagraph. This correspondence of spatial locations at both wavelengths confirms tha...

  1. Early modality-specific somatosensory cortical regions are modulated by attended visual stimuli: interaction of vision, touch and behavioral intent.

    Directory of Open Access Journals (Sweden)

    W. Richard Staines

    2014-04-01

    Full Text Available Bimodal interactions between relevant visual and tactile inputs can facilitate attentional modulation at early stages in somatosensory cortices to achieve goal-oriented behaviors. However, the specific contribution of each sensory system during attentional processing and, importantly, how these interact with the required behavioural motor goals remains unclear. Here we used EEG and event-related potentials (ERPs to test the hypothesis that activity from modality-specific somatosensory cortical regions would be enhanced with task-relevant bimodal (visual-tactile stimuli and that the degree of modulation would depend on the difficulty of the associated sensory-motor task demands. Tactile stimuli were discrete vibrations to the index finger and visual stimuli were horizontal bars on a computer screen, both with random amplitudes. Streams of unimodal (tactile and crossmodal (visual and tactile stimuli were randomly presented and participants were instructed to attend to one type of stimulus (unimodal or crossmodal and responses involved either an indication of the presence of an attended stimulus (detect, or the integration and summation of 2 stimulus amplitudes using a pressure-sensitive ball (grade. Force-amplitude associations were learned in a training session, and no feedback was provided during the task. ERPs were time-locked to tactile stimuli and extracted for early modality-specific components (P50, P100, N140. The P50 was enhanced with bimodal (visual-tactile stimuli that were attended to. This was maximal when the motor requirements involved integration of the 2 stimuli in the grade task and when the visual stimulus occurred before (100 ms the tactile stimulus. These results suggest that visual information relevant for movement modulates early somatosensory processing and that the motor behavioral context influences this likely through interaction of top-down attentional and motor preparatory systems with more bottom-up crossmodal

  2. Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb.

    Science.gov (United States)

    Neufeld, Stanley J; Wang, Fan; Cobb, John

    2014-11-01

    The growth and development of the vertebrate limb relies on homeobox genes of the Hox and Shox families, with their independent mutation often giving dose-dependent effects. Here we investigate whether Shox2 and Hox genes function together during mouse limb development by modulating their relative dosage and examining the limb for nonadditive effects on growth. Using double mRNA fluorescence in situ hybridization (FISH) in single embryos, we first show that Shox2 and Hox genes have associated spatial expression dynamics, with Shox2 expression restricted to the proximal limb along with Hoxd9 and Hoxa11 expression, juxtaposing the distal expression of Hoxa13 and Hoxd13. By generating mice with all possible dosage combinations of mutant Shox2 alleles and HoxA/D cluster deletions, we then show that their coordinated proximal limb expression is critical to generate normally proportioned limb segments. These epistatic interactions tune limb length, where Shox2 underexpression enhances, and Shox2 overexpression suppresses, Hox-mutant phenotypes. Disruption of either Shox2 or Hox genes leads to a similar reduction in Runx2 expression in the developing humerus, suggesting their concerted action drives cartilage maturation during normal development. While we furthermore provide evidence that Hox gene function influences Shox2 expression, this regulation is limited in extent and is unlikely on its own to be a major explanation for their genetic interaction. Given the similar effect of human SHOX mutations on regional limb growth, Shox and Hox genes may generally function as genetic interaction partners during the growth and development of the proximal vertebrate limb.

  3. Stereotype threat and racial differences in citizens' experiences of police encounters.

    Science.gov (United States)

    Najdowski, Cynthia J; Bottoms, Bette L; Goff, Phillip Atiba

    2015-10-01

    We conducted 2 studies to investigate how cultural stereotypes that depict Blacks as criminals affect the way Blacks experience encounters with police officers, expecting that such encounters induce Blacks to feel stereotype threat (i.e., concern about being judged and treated unfairly by police because of the stereotype). In Study 1, we asked Black and White participants to report how they feel when interacting with police officers in general. As predicted, Blacks, but not Whites, reported concern that police officers stereotype them as criminals simply because of their race. In addition, this effect was found for Black men but not Black women. In Study 2, we asked Black and White men to imagine a specific police encounter and assessed potential downstream consequences of stereotype threat. Consistent with Study 1, Black but not White men anticipated feeling stereotype threat in the hypothetical police encounter. Further, racial differences in anticipated threat translated into racial differences in anticipated anxiety, self-regulatory efforts, and behavior that is commonly perceived as suspicious by police officers. By demonstrating that Blacks might expect to be judged and treated unfairly by police because of the negative stereotype of Black criminality, this research extends stereotype threat theory to the new domain of criminal justice encounters. It also has practical implications for understanding how the stereotype could ironically contribute to bias-based policing and racial disparities in the justice system.

  4. The effect of the high-speed stream following the corotating interaction region on the geomagnetic activities

    Directory of Open Access Journals (Sweden)

    S. Watari

    Full Text Available The high-speed stream following the corotating interaction regions (CIRs was analyzed. As a result of the analysis, it is found that the geomagnetic field is continuously disturbed in the high-speed stream in question. The geomagnetic disturbances with long duration recurred several rotations between December 1993 and June 1994. These disturbances were associated with a large recurrent coronal hole expanding from the south pole of the Sun. High-speed solar wind from this coronal hole was observed by the IMP-8 satellite during this period. However, the observed intensities of the geomagnetic disturbances were different for each recurrent period. This is explained by the seasonal effect. The disturbed geomagnetic condition continued in the high-speed stream after the passage of the CIRs. The long duration of these disturbances can be explained by the continuous energy input into the Earth's magnetosphere from the high-speed regions following the CIRs. This kind of long-duration geomagnetic disturbance in association with coronal holes has been observed in the declining phase of other solar cycles. The relation between the coronal-hole area and the maximum solar-wind velocity is not good for the well-developed large coronal hole analyzed here.

  5. Direct evidence of megamammal-carnivore interaction decoded from bone marks in historical fossil collections from the Pampean region

    Directory of Open Access Journals (Sweden)

    Karina Vanesa Chichkoyan

    2017-05-01

    Full Text Available Pleistocene South American megafauna has traditionally attracted the interest of scientists and the popular media alike. However, ecological interactions between the species that inhabited these ecosystems, such as predator-prey relationships or interspecific competition, are poorly known. To this regard, carnivore marks imprinted on the fossil bones of megamammal remains are very useful for deciphering biological activity and, hence, potential interspecific relationships among taxa. In this article, we study historical fossil collections housed in different European and Argentinean museums that were excavated during the 19th and early 20th centuries in the Pampean region, Argentina, in order to detect carnivore marks on bones of megamammals and provide crucial information on the ecological relationships between South American taxa during the Pleistocene. Our results indicate that the long bones of megafauna from the Pampean region (e.g., the Mylodontidae and Toxodontidae families exhibit carnivore marks. Furthermore, long bones of medium-sized species and indeterminate bones also present punctures, pits, scores and fractures. Members of the large-carnivore guild, such as ursids, canids and even felids, are recognised as the main agents that inflicted the marks. We hypothesize that the analysed carnivore marks represent the last stages of megaherbivore carcass exploitation, suggesting full consumption of these animals by the same or multiple taxa in a hunting and/or scavenging scenario. Moreover, our observations provide novel insights that help further our understanding of the palaeoecological relationships of these unique communities of megamammals.

  6. Controlling the processes of impact interaction of a tool with rocks in the region of spasmodic destruction frequencies

    Energy Technology Data Exchange (ETDEWEB)

    Dzidziguri, A.A.; Sepiashvili, A.D.; Yamanidze, T.Sh.

    1983-01-01

    A working hypothesis is described which made it possible to take into consideration the wave processes occurring in the drilling tool, and the discrete nature of crushing of rocks in limits of a single impact. A mathematical model is given for the process of impact interaction of the drilling tool with the rock. It is indicated that the nonlinear elastic link with assigned rigid characteristics under conditions of single-frequency harmonic effect result in excitation of the highest odd harmonics. It follows from this that the contact region which is a nonlinear fluctuating contour in the same way as the wave reflector can create with definite conditions polyresonance modes of oscillations of the working end of the drilling tool, and promote intensification of the processes of spasmodic crushing of rocks in systems of direct impact or impact through the drilling machine. Practical realization of the optimal nonlinear elastic bond in the region of contact of crushing tool with the rock is possible by optimizing form, dimensions and elastic properties of the crushing tool.

  7. Regional repression of a Drosophila POU box gene in the endoderm involves inductive interactions between germ layers.

    Science.gov (United States)

    Affolter, M; Walldorf, U; Kloter, U; Schier, A F; Gehring, W J

    1993-04-01

    An induction process occurring between the mesodermal and the endodermal germ layers has recently been described in the regulation of the Drosophila homeotic gene labial (lab). We report here that proper spatial regulation of the Drosophila POU box gene pdm-1 products also involves interaction between these two germ layers. pdm-1 transcripts are initially present in both the anterior and the posterior endodermal midgut primordia. Upon fusion of the two primordia, transcripts disappear from two regions in the endoderm, a central domain and an anterior domain. The anterior repression domain of pdm-1 is independent of the expression of known homeotic genes and genes encoding secreted signalling molecules in the visceral mesoderm, both for its positioning and its repression. Repression in the central domain requires both the homeotic gene Ultrabithorax (Ubx) and the decapentaplegic (dpp) gene, which encodes a secreted protein. Both of these genes are also required for lab induction. However, the analysis of pdm-1 expression in various mutant backgrounds indicates that the regulation of lab and pdm-1 across germ layers is controlled by different genetic cascades. Our study indicates that dpp is not the signal that dictates central pdm-1 repression across germ layers and suggests that in the same midgut region, different signalling pathways result in the differential activation or repression of potential transcription factors.

  8. Climate Risk and Vulnerability in the Caribbean and Gulf of Mexico Region: Interactions with Spatial Population and Land Cover Change

    Science.gov (United States)

    Chen, R. S.; Levy, M.; Baptista, S.; Adamo, S.

    2010-12-01

    Vulnerability to climate variability and change will depend on dynamic interactions between different aspects of climate, land-use change, and socioeconomic trends. Measurements and projections of these changes are difficult at the local scale but necessary for effective planning. New data sources and methods make it possible to assess land-use and socioeconomic changes that may affect future patterns of climate vulnerability. In this paper we report on new time series data sets that reveal trends in the spatial patterns of climate vulnerability in the Caribbean/Gulf of Mexico Region. Specifically, we examine spatial time series data for human population over the period 1990-2000, time series data on land use and land cover over 2000-2009, and infant mortality rates as a proxy for poverty for 2000-2008. We compare the spatial trends for these measures to the distribution of climate-related natural disaster risk hotspots (cyclones, floods, landslides, and droughts) in terms of frequency, mortality, and economic losses. We use these data to identify areas where climate vulnerability appears to be increasing and where it may be decreasing. Regions where trends and patterns are especially worrisome include coastal areas of Guatemala and Honduras.

  9. Linkage Analysis of Genomic Regions Contributing to the Expression of Type 1 Diabetes Microvascular Complications and Interaction with HLA

    Directory of Open Access Journals (Sweden)

    Ettie M. Lipner

    2015-01-01

    Full Text Available We conducted linkage analysis to follow up earlier work on microvascular complications of type 1 diabetes (T1D. We analyzed 415 families (2,008 individuals previously genotyped for 402 SNP markers spanning chromosome 6. We did linkage analysis for the phenotypes of retinopathy and nephropathy. For retinopathy, two linkage peaks were mapped: one located at the HLA region and another novel locus telomeric to HLA. For nephropathy, a linkage peak centromeric to HLA was mapped, but the linkage peak telomeric to HLA seen in retinopathy was absent. Because of the strong association of T1D with DRB1*03:01 and DRB1*04:01, we stratified our analyses based on families whose probands were positive for DRB1*03:01 or DRB1*04:01. When analyzing the DRB1*03:01-positive retinopathy families, in addition to the novel telomeric locus, one centromeric to HLA was identified at the same location as the nephropathy peak. When we stratified on DRB1*04:01-positive families, the HLA telomeric peak strengthened but the centromeric peak disappeared. Our findings showed that HLA and non-HLA loci on chromosome 6 are involved in T1D complications’ expression. While the HLA region is a major contributor to the expression of T1D, our results suggest an interaction between specific HLA alleles and other loci that influence complications’ expression.

  10. Wellness Tourism among Seniors in Taiwan: Previous Experience, Service Encounter Expectations, Organizational Characteristics, Employee Characteristics, and Customer Satisfaction

    Directory of Open Access Journals (Sweden)

    Kaung-Hwa Chen

    2015-08-01

    Full Text Available This study aimed to investigate the influence of the service encounter expectations of senior customers during wellness tours on customer satisfaction. The organizational attributes of hotels, organizational characteristics and employee characteristics, were adopted as mediating variables. A total of 346 valid questionnaires were retrieved from 50 year-old and above seniors in Taiwan. The results showed that the service encounter expectations of seniors had an indirect influence on customer satisfaction and the organizational attributes mediated the service encounter expectations of seniors and customer satisfaction. The moment of truth in the interactions between service staff members and seniors represents the pivotal management implication of this study.

  11. Distinct regions of Galpha13 participate in its regulatory interactions with RGS homology domain-containing RhoGEFs.

    Science.gov (United States)

    Kreutz, Barry; Hajicek, Nicole; Yau, Douglas M; Nakamura, Susumu; Kozasa, Tohru

    2007-08-01

    Galpha12 and Galpha13 transduce signals from G protein-coupled receptors to RhoA through RhoGEFs containing an RGS homology (RH) domain, such as p115 RhoGEF or leukemia-associated RhoGEF (LARG). The RH domain of p115 RhoGEF or LARG binds with high affinity to active forms of Galpha12 and Galpha13 and confers specific GTPase-activating protein (GAP) activity, with faster GAP responses detected in Galpha13 than in Galpha12. At the same time, Galpha13, but not Galpha12, directly stimulates the RhoGEF activity of p115 RhoGEF or nonphosphorylated LARG in reconstitution assays. In order to better understand the molecular mechanism by which Galpha13 regulates RhoGEF activity through interaction with RH-RhoGEFs, we sought to identify the region(s) of Galpha13 involved in either the GAP response or RhoGEF activation. For this purpose, we generated chimeras between Galpha12 and Galpha13 subunits and characterized their biochemical activities. In both cell-based and reconstitution assays of RhoA activation, we found that replacing the carboxyl-terminal region of Galpha12 (residues 267-379) with that of Galpha13 (residues 264-377) conferred gain-of-function to the resulting chimeric subunit, Galpha12C13. The inverse chimera, Galpha13C12, exhibited basal RhoA activation which was similar to Galpha12. In contrast to GEF assays, GAP assays showed that Galpha12C13 or Galpha13C12 chimeras responded to the GAP activity of p115 RhoGEF or LARG in a manner similar to Galpha12 or Galpha13, respectively. We conclude from these results that the carboxyl-terminal region of Galpha13 (residues 264-377) is essential for its RhoGEF stimulating activity, whereas the amino-terminal alpha helical and switch regions of Galpha12 and Galpha13 are responsible for their differential GAP responses to the RH domain.

  12. Busting Up Binaries: Encounters Between Compact Binaries and a Supermassive Black Hole

    CERN Document Server

    Addison, Eric; Larson, Shane

    2015-01-01

    Given the stellar density near the galactic center, close encounters between compact object binaries and the supermassive black hole are a plausible occurrence. We present results from a numerical study of close to 13 million such encounters. Consistent with previous studies, we corroborate that, for binary systems tidally disrupted by the black hole, the component of the binary remaining bound to the hole has eccentricity ~ 0.97 and circularizes dramatically by the time it enters the classical LISA band. Our results also show that the population of surviving binaries merits attention. These binary systems experience perturbations to their internal orbital parameters with potentially interesting observational consequences. We investigated the regions of parameter space for survival and estimated the distribution of orbital parameters post-encounter. We found that surviving binaries harden and their eccentricity increases, thus accelerating their merger due gravitational radiation emission and increasing the p...

  13. Aerosol-radiation-cloud interactions in a regional coupled model: the effects of convective parameterisation and resolution

    Science.gov (United States)

    Archer-Nicholls, Scott; Lowe, Douglas; Schultz, David M.; McFiggans, Gordon

    2016-05-01

    The Weather Research and Forecasting model with Chemistry (WRF-Chem) has been used to simulate a region of Brazil heavily influenced by biomass burning. Nested simulations were run at 5 and 1 km horizontal grid spacing for three case studies in September 2012. Simulations were run with and without fire emissions, convective parameterisation on the 5 km domain, and aerosol-radiation interactions in order to explore the differences attributable to the parameterisations and to better understand the aerosol direct effects and cloud responses. Direct aerosol-radiation interactions due to biomass burning aerosol resulted in a net cooling, with an average short-wave direct effect of -4.08 ± 1.53 Wm-2. However, around 21.7 Wm-2 is absorbed by aerosol in the atmospheric column, warming the atmosphere at the aerosol layer height, stabilising the column, inhibiting convection, and reducing cloud cover and precipitation. The changes to clouds due to radiatively absorbing aerosol (traditionally known as the semi-direct effects) increase the net short-wave radiation reaching the surface by reducing cloud cover, producing a secondary warming that counters the direct cooling. However, the magnitude of the semi-direct effect was found to be extremely sensitive to the model resolution and the use of convective parameterisation. Precipitation became organised in isolated convective cells when not using a convective parameterisation on the 5 km domain, reducing both total cloud cover and total precipitation. The SW semi-direct effect varied from 6.06 ± 1.46 with convective parameterisation to 3.61 ± 0.86 Wm-2 without. Convective cells within the 1 km domain are typically smaller but with greater updraft velocity than equivalent cells in the 5 km domain, reducing the proportion of the domain covered by cloud in all scenarios and producing a smaller semi-direct effect. Biomass burning (BB) aerosol particles acted as cloud condensation nuclei (CCN), increasing the droplet number

  14. Assessing regional scale predictions of aerosols, marine stratocumulus, and their interactions during VOCALS-REx using WRF-Chem

    Directory of Open Access Journals (Sweden)

    Q. Yang

    2011-12-01

    Full Text Available This study assesses the ability of the recent chemistry version (v3.3 of the Weather Research and Forecasting (WRF-Chem model to simulate boundary layer structure, aerosols, stratocumulus clouds, and energy fluxes over the Southeast Pacific Ocean. Measurements from the VAMOS Ocean-Cloud-Atmosphere-Land Study Regional Experiment (VOCALS-REx and satellite retrievals (i.e., products from the MODerate resolution Imaging Spectroradiometer (MODIS, Clouds and Earth's Radiant Energy System (CERES, and GOES-10 are used for this assessment. The Morrison double-moment microphysics scheme is newly coupled with interactive aerosols in the model. The 31-day (15 October–16 November 2008 WRF-Chem simulation with aerosol-cloud interactions (AERO hereafter is also compared to a simulation (MET hereafter with fixed cloud droplet number concentrations in the microphysics scheme and simplified cloud and aerosol treatments in the radiation scheme. The well-simulated aerosol quantities (aerosol number, mass composition and optical properties, and the inclusion of full aerosol-cloud couplings lead to significant improvements in many features of the simulated stratocumulus clouds: cloud optical properties and microphysical properties such as cloud top effective radius, cloud water path, and cloud optical thickness. In addition to accounting for the aerosol direct and semi-direct effects, these improvements feed back to the simulation of boundary-layer characteristics and energy budgets. Particularly, inclusion of interactive aerosols in AERO strengthens the temperature and humidity gradients within the capping inversion layer and lowers the marine boundary layer (MBL depth by 130 m from that of the MET simulation. These differences are associated with weaker entrainment and stronger mean subsidence at the top of the MBL in AERO. Mean top-of-atmosphere outgoing shortwave fluxes, surface latent heat, and surface downwelling longwave fluxes are in better agreement with

  15. Interactive effects of apolipoprotein E4 and diabetes risk on later myelinating white matter regions in neurologically healthy older aged adults.

    Science.gov (United States)

    Foley, Jessica M; Salat, David H; Stricker, Nikki H; Zink, Tyler A; Grande, Laura J; McGlinchey, Regina E; Milberg, William P; Leritz, Elizabeth C

    2014-05-01

    Possession of the apolipoprotein E4 (APOE4) allele and diabetes risk are independently related to reduced white matter (WM) integrity that may contribute to the development of Alzheimer's disease (AD). The purpose of this study is to examine the interactive effects of APOE4 and diabetes risk on later myelinating WM regions among healthy elderly individuals at risk of AD. A sample of 107 healthy elderly (80 APOE4-/27 APOE4+) individuals underwent structural magnetic resonance imaging/diffusion tensor imaging (DTI). Data were prepared using Tract-Based Spatial Statistics, and a priori regions of interest (ROIs) were extracted from T1-based WM parcellations. Regions of interest included later myelinating frontal/temporal/parietal WM regions and control regions measured by fractional anisotropy (FA). There were no APOE group differences in DTI for any ROI. Within the APOE4 group, we found negative relationships between hemoglobin A1c/fasting glucose and APOE4 on FA for all later myelinating WM regions but not for early/middle myelinating control regions. Results also showed APOE4/diabetes risk interactions for WM underlying supramarginal, superior temporal, precuneus, superior parietal, and superior frontal regions. Results suggest interactive effects of APOE4 and diabetes risk on later myelinating WM regions, which supports preclinical detection of AD among this particularly susceptible subgroup.

  16. Nucleosome free regions in yeast promoters result from competitive binding of transcription factors that interact with chromatin modifiers.

    Directory of Open Access Journals (Sweden)

    Evgeniy A Ozonov

    Full Text Available Because DNA packaging in nucleosomes modulates its accessibility to transcription factors (TFs, unraveling the causal determinants of nucleosome positioning is of great importance to understanding gene regulation. Although there is evidence that intrinsic sequence specificity contributes to nucleosome positioning, the extent to which other factors contribute to nucleosome positioning is currently highly debated. Here we obtained both in vivo and in vitro reference maps of positions that are either consistently covered or free of nucleosomes across multiple experimental data-sets in Saccharomyces cerevisiae. We then systematically quantified the contribution of TF binding to nucleosome positioning using a rigorous statistical mechanics model in which TFs compete with nucleosomes for binding DNA. Our results reconcile previous seemingly conflicting results on the determinants of nucleosome positioning and provide a quantitative explanation for the difference between in vivo and in vitro positioning. On a genome-wide scale, nucleosome positioning is dominated by the phasing of nucleosome arrays over gene bodies, and their positioning is mainly determined by the intrinsic sequence preferences of nucleosomes. In contrast, larger nucleosome free regions in promoters, which likely have a much more significant impact on gene expression, are determined mainly by TF binding. Interestingly, of the 158 yeast TFs included in our modeling, we find that only 10-20 significantly contribute to inducing nucleosome-free regions, and these TFs are highly enriched for having direct interactions with chromatin remodelers. Together our results imply that nucleosome free regions in yeast promoters results from the binding of a specific class of TFs that recruit chromatin remodelers.

  17. Nucleosome free regions in yeast promoters result from competitive binding of transcription factors that interact with chromatin modifiers.

    Science.gov (United States)

    Ozonov, Evgeniy A; van Nimwegen, Erik

    2013-01-01

    Because DNA packaging in nucleosomes modulates its accessibility to transcription factors (TFs), unraveling the causal determinants of nucleosome positioning is of great importance to understanding gene regulation. Although there is evidence that intrinsic sequence specificity contributes to nucleosome positioning, the extent to which other factors contribute to nucleosome positioning is currently highly debated. Here we obtained both in vivo and in vitro reference maps of positions that are either consistently covered or free of nucleosomes across multiple experimental data-sets in Saccharomyces cerevisiae. We then systematically quantified the contribution of TF binding to nucleosome positioning using a rigorous statistical mechanics model in which TFs compete with nucleosomes for binding DNA. Our results reconcile previous seemingly conflicting results on the determinants of nucleosome positioning and provide a quantitative explanation for the difference between in vivo and in vitro positioning. On a genome-wide scale, nucleosome positioning is dominated by the phasing of nucleosome arrays over gene bodies, and their positioning is mainly determined by the intrinsic sequence preferences of nucleosomes. In contrast, larger nucleosome free regions in promoters, which likely have a much more significant impact on gene expression, are determined mainly by TF binding. Interestingly, of the 158 yeast TFs included in our modeling, we find that only 10-20 significantly contribute to inducing nucleosome-free regions, and these TFs are highly enriched for having direct interactions with chromatin remodelers. Together our results imply that nucleosome free regions in yeast promoters results from the binding of a specific class of TFs that recruit chromatin remodelers.

  18. INTERACTION BETWEEN THE TRADITIONAL AND INNOVATIVE APPROACHES IN TRAINING PHARMACISTS FOR THEIR PROFESSIONAL WORK IN THE CARPATHIAN REGION

    Directory of Open Access Journals (Sweden)

    Mariana Drachuk

    2015-04-01

    Full Text Available This paper presented the modern automated diagnostic systems and pharmacological rehabilitation technologies. There is a lack in the raw material base of many medicinal plants due to the bad environmental situation. Today natural resources were so depleted that Arnica was listed in the Red Book of Ukraine. Nowadays the training of specialists in the field of pharmacology requires not only new approaches associated with the development of medical science and computer technology. We have national traditions for the use of plant resources, particularly in the Carpathian region. Much of the research in the field of pharmacology requires new approaches in the analysis of clinical trails of new medical products. Pharmaceutical practice is focused on the types of professional activities. The ethical aspects related to medicines are equally significant. In the professional work of pharmacists information technologies are used on such stages as the creation of a medicinal product. The research of resources is conducted all over the world and is used to record all types of natural resources, but this term is most commonly used to define plant resources. The pharmacist should be able to adjust the recipes prescribed by doctors and know the rules of drug intake and provision. Regarding plant medicines, the Carpathian region has a rich heritage of traditional use of medical plants. Nowadays modern conditions require the active use of new technologies in pharmacist’s professional activity. Particularly acute is the problem of compatibility of medicinal substances and their interaction in the pharmaceutical phase as well as in the process of distribution and absorption. The Carpathian region which is extremely rich in medical plants should be constantly studied and integrated with the modern knowledge and capabilities

  19. Encounters between Alpine ibex, Alpine chamois and domestic sheep in the Swiss Alps

    Directory of Open Access Journals (Sweden)

    Marie-Pierre Ryser-Degiorgis

    2002-12-01

    Full Text Available Abstract Information regarding spatio-temporal relationships and encounters of sympatric domestic sheep, Alpine ibex (Capra ibex ibex and Alpine chamois (Rupicapra rupicapra rupicapra in the Swiss Alps were systematically registered to evaluate the possibility of an interspecific transmission of infectious agents on pastures. Observations were performed in alpine regions of four Swiss cantons during the 1997 and 1998 mountain summer grazing season. In the main study area, Val Chamuera (canton of Grisons, a consistent reduction in the number of ibexes was observed after the arrival of sheep on the pasture. Some ibexes remained for a longer time in the area, but in general, ibexes and sheep did not use the same compartments of the area simultaneously. However, a salt lick for sheep attracted the ibexes, and several encounters were recorded in the compartments close to this salt lick. Several encounters registered in other areas of the Swiss Alps also occurred in the neighbourhood of a salt lick; however, in other cases different species were attracted by rich pastures. The study indicates that encounters (0-50 m between free-ranging individuals of different Caprinae species, domestic and wild, are not uncommon events in the Alps. Therefore, encounters can be considered to be a predisposing factor for interspecific transmission of infectious agents such as Mycoplasma conjunctivae, causing keratoconjunctivitis in chamois, ibex, domestic sheep and goats.

  20. The Rings of Chariklo under Close Encounters with the Giant Planets

    Science.gov (United States)

    Araujo, R. A. N.; Sfair, R.; Winter, O. C.

    2016-06-01

    The Centaur population is composed of minor bodies wandering between the giant planets that frequently perform close gravitational encounters with these planets, leading to a chaotic orbital evolution. Recently, the discovery of two well-defined narrow rings was announced around the Centaur 10199 Chariklo. The rings are assumed to be in the equatorial plane of Chariklo and to have circular orbits. The existence of a well-defined system of rings around a body in such a perturbed orbital region poses an interesting new problem. Are the rings of Chariklo stable when perturbed by close gravitational encounters with the giant planets? Our approach to address this question consisted of forward and backward numerical simulations of 729 clones of Chariklo, with similar initial orbits, for a period of 100 Myr. We found, on average, that each clone experiences during its lifetime more than 150 close encounters with the giant planets within one Hill radius of the planet in question. We identified some extreme close encounters that were able to significantly disrupt or disturb the rings of Chariklo. About 3% of the clones lose their rings and about 4% of the clones have their rings significantly disturbed. Therefore, our results show that in most cases (more than 90%), the close encounters with the giant planets do not affect the stability of the rings in Chariklo-like systems. Thus, if there is an efficient mechanism that creates the rings, then these structures may be common among these kinds of Centaurs.

  1. Estimating migratory connectivity of birds when re-encounter probabilities are heterogeneous

    Science.gov (United States)

    Cohen, Emily B.; Hostelter, Jeffrey A.; Royle, J. Andrew; Marra, Peter P.

    2014-01-01

    Understanding the biology and conducting effective conservation of migratory species requires an understanding of migratory connectivity – the geographic linkages of populations between stages of the annual cycle. Unfortunately, for most species, we are lacking such information. The North American Bird Banding Laboratory (BBL) houses an extensive database of marking, recaptures and recoveries, and such data could provide migratory connectivity information for many species. To date, however, few species have been analyzed for migratory connectivity largely because heterogeneous re-encounter probabilities make interpretation problematic. We accounted for regional variation in re-encounter probabilities by borrowing information across species and by using effort covariates on recapture and recovery probabilities in a multistate capture–recapture and recovery model. The effort covariates were derived from recaptures and recoveries of species within the same regions. We estimated the migratory connectivity for three tern species breeding in North America and over-wintering in the tropics, common (Sterna hirundo), roseate (Sterna dougallii), and Caspian terns (Hydroprogne caspia). For western breeding terns, model-derived estimates of migratory connectivity differed considerably from those derived directly from the proportions of re-encounters. Conversely, for eastern breeding terns, estimates were merely refined by the inclusion of re-encounter probabilities. In general, eastern breeding terns were strongly connected to eastern South America, and western breeding terns were strongly linked to the more western parts of the nonbreeding range under both models. Through simulation, we found this approach is likely useful for many species in the BBL database, although precision improved with higher re-encounter probabilities and stronger migratory connectivity. We describe an approach to deal with the inherent biases in BBL banding and re-encounter data to demonstrate

  2. DAFNE Interaction Regions upgrade

    CERN Document Server

    Milardi, C; Biagini, M E; Biscari, C; Boni, R; Boscolo, M; Bossi, F; Buonomo, B; Clozza, A; Delle Monache, G; Demma, T; Di Pasquale, E; Di Pirro, G; Drago, A; Gallo, A; Ghigo, A; Guiducci, S; Ligi, C; Marcellini, F; Mazzitelli, G; Murtas, F; Pellegrino, L; Preger, M; Quintieri, L; Raimondi, P; Ricci, R; Rotundo, U; Sanelli, C; Serio, M; Sgamma, F; Spataro, B; Stecchi, A; Stella, A; Tomassini, S; Vaccarezza, C; Zobov, M; Koop, I; Levichev, E; Piminov, P; Shatilov, D; Smaluk, V; Bettoni, S; Schioppa, M; Valente, P; Ohmi, K; Arnaud, N; Breton, D; Roudeau, P; Stocchi, A; Variola, A; Viaud, B.F; Esposito, M; Paoloni, E; Branchini, P

    2008-01-01

    DAFNE, the Frascati F-factory, has recently completed experimental runs for the three main detectors, KLOE, FINUDA and DEAR achieving 1.6x10E+32 cm-2s-1 peak and 10 pb-1 daily integrated luminosities. Improving these results by a significant factor requires changing the collision scheme. For this reason, in view of the SIDDHARTA detector installation, relevant modifications of the machine have been realized, aimed at implementing a new collision scheme based on a large Piwinski angle and crab-waist, together with several other hardware modifications involving injection kickers, bellows and beam pipe sections.

  3. CBF mediates adenovirus Ela trans-activation by interaction at the C-terminal promoter targeting domain of conserved region 3.

    Science.gov (United States)

    Agoff, S N; Wu, B

    1994-12-01

    Genetic and biochemical evidence suggest that conserved region 3 (CR3) of the adenovirus Ela polypeptide can provide two distinct and separable functions: an N-terminal transcriptional activation region and a C-terminal promoter targeting region. It is thought that the promoter targeting region of Ela CR3 interacts with promoter-specific transcription factors, thereby bringing the activation region of Ela CR3 in proximity of the promoter. Here we report that CBF, a CCAAT-box-binding factor that regulates hsp70 gene expression and mediates Ela trans-activation in vivo, interacts with the promoter targeting region of Ela CR3 in vitro. Point mutations in Ela CR3 that are defective in stimulating transcription from the hsp70 promoter are also defective in stimulating transcription directed by a synthetic activator, GAL-CBF, composed of the DNA-binding domain of yeast GAL4 fused to CBF. These mutations fall into two classes with respect to their abilities to interact with CBF in vitro. Mutations in the transcriptional activation region of Ela CR3 do not affect binding to CBF, but mutation of the promoter targeting region of Ela CR3 prevents association with CBF in vitro.

  4. Tourism Encounters and Controversies: Ontological Politics of Tourism Development

    NARCIS (Netherlands)

    Jóhannesson, G.T.; Ren, C.; Duim, van der V.R.

    2015-01-01

    The multiplicity of tourism encounters provide some of the best available occasions to observe the social world and its making(s). Focusing on ontological politics of tourism development, this book examines how different versions of tourism are enacted, how encounters between different versions of t

  5. Managing the bank service encounter: A conceptual model

    Directory of Open Access Journals (Sweden)

    K. K. Govender

    1999-06-01

    Full Text Available In financial services marketing, especially among banks, there are a limited number of chances to impress the customer, since the services are becoming more automated. Since personal interactions with customers are becoming less numerous, customers are expecting higher quality contacts and more individual treatment. This paper proposes a service encounter management model which may impact on the customers service experience. By matching service employees with customers, the effects of certain human resources strategies may be ascertained through the customers perception of the employee service quality and the overall service quality. Opsomming Daar is 'n beperkte geleenthede om die finansiele dienste klient, veral die in banke, te beindruk, aangesien dienste al meer ge-outomatiseer raak. Seinde persoonlike kontak met kliente al minder word, verwag kliente hoer gehalte kontak en meer individuele behandeling. Hierdie artikel stel 'n bestuursmodel vir diensontmoetings voor wat 'n impak op kliente se dienservarings mag he. Deur dienswerknemers met kliente te verbind kan bepaalde menslike hulpbronstrategie-effekte vasgestel word, deur middel van kliente se persepsie van werknemer-diensgehalte en algemene diensgehalte.

  6. Identification of distinct nisin leader peptide regions that determine interactions with the modification enzymes NisB and NisC.

    Science.gov (United States)

    Khusainov, Rustem; Moll, Gert N; Kuipers, Oscar P

    2013-01-01

    Nisin is the most prominent and applied bacteriocin that serves as a model for class I lantibiotics. The nisin leader peptide importantly determines interactions between precursor nisin and its modification enzymes NisB and NisC that mature nisin posttranslationally. NisB dehydrates serines and threonines, while NisC catalyzes the subsequent coupling of the formed dehydroamino acids to form lanthionines. Currently, little is known about how the nisin leader interacts with NisB and even less is known about its interactions with NisC. To investigate the nisin leader peptide requirements for functional interaction with the modification enzymes NisB and NisC, we systematically replaced six regions, of 2-4 amino acids each, with all-alanine regions. By performing NisB and NisC co-purification studies with these mutant leader peptides, we demonstrate that the nisin leader regions STKD(-22-19), FNLD(-18-15) and PR(-2-1) importantly contribute to the interactions of precursor nisin with both NisB and NisC, whereas the nisin leader region LVSV(-14-11) additionally contributes to the interaction of precursor nisin with NisC.

  7. NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation

    Directory of Open Access Journals (Sweden)

    Bruix Marta

    2010-01-01

    Full Text Available Abstract Background Some functions of 4.1R in non-erythroid cells are directly related with its distinct sub-cellular localisation during cell cycle phases. During mitosis, 4.1R is implicated in cell cycle progression and spindle pole formation, and co-localizes with NuMA1. However, during interphase 4.1R is located in the nucleus and only partially co-localizes with NuMA1. Results We have characterized by NMR the structural features of the C-terminal domain of 4.1R and those of the minimal region (the last 64 residues involved in the interaction with NuMA1. This subdomain behaves as an intrinsically unfolded protein containing a central region with helical tendency. The specific residues implicated in the interaction with NuMA1 have been mapped by NMR titrations and involve the N-terminal and central helical regions. The segment of NuMA1 that interacts with 4.1R is phosphorylated during mitosis. Interestingly, NMR data indicates that the phosphorylation of NuMA1 interacting peptide provokes a change in the interaction mechanism. In this case, the recognition occurs through the central helical region as well as through the C-terminal region of the subdomain meanwhile the N-terminal region do not interact. Conclusions These changes in the interaction derived from the phosphorylation state of NuMA1 suggest that phosphorylation can act as subtle mechanism of temporal and spatial regulation of the complex 4.1R-NuMA1 and therefore of the processes where both proteins play a role.

  8. The remains of a spinning, hyperbolic encounter

    CERN Document Server

    De Vittori, Lorenzo; Gupta, Anuradha; Jetzer, Philippe

    2014-01-01

    We review a recently proposed approach to construct gravitational wave (GW) polarization states of unbound spinning compact binaries. Through this rather simple method, we are able to include corrections due to the dominant order spin-orbit interactions, in the quadrupolar approximation and in a semi-analytic way. We invoke the 1.5 post-Newtonian (PN) accurate quasi-Keplerian parametrization for the radial part of the dynamics and impose its temporal evolution in the PN accurate polarization states equations. Further, we compute 1PN accurate amplitude corrections for the polarization states of non-spinning compact binaries on hyperbolic orbits. As an interesting application, we perform comparisons with previously available results for both the GW signals in the case of non-spinning binaries and the theoretical prediction for the amplitude of the memory effect on the metric after the hyperbolic passage.

  9. GASP cloud encounter statistics - Implications for laminar flow control flight

    Science.gov (United States)

    Jasperson, W. H.; Nastrom, G. D.; Davis, R. E.; Holdeman, J. D.

    1984-01-01

    The cloud observation archive from the NASA Global Atmospheric Sampling Program (GASP) is analyzed in order to derive the probability of cloud encounter at altitudes normally flown by commercial airliners, for application to a determination of the feasability of Laminar Flow Control (LFC) on long-range routes. The probability of cloud encounter is found to vary significantly with season. Several meteorological circulation features are apparent in the latitudinal distribution of cloud cover. The cloud encounter data are shown to be consistent with the classical midlatitude cyclone model with more clouds encountered in highs than in lows. Aircraft measurements of route-averaged time-in-clouds fit a gamma probability distribution model which is applied to estimate the probability of extended cloud encounter, and the associated loss of LFC effectiveness along seven high-density routes. The probability is demonstrated to be low.

  10. The space of togetherness--a caring encounter.

    Science.gov (United States)

    Holopainen, Gunilla; Kasén, Anne; Nyström, Lisbet

    2014-03-01

    Encounters in relation to the nurse-patient relationship are often discussed within nursing and caring literature without a reflection on the actual meaning of the concept. Assuming that an encounter is essential for nursing care, this article seeks to create a deeper understanding of the concept through a hermeneutic approach to texts by the philosophers Buber and Marcel. Presence, recognition, availability and mutuality seem to be essential prerequisites for an encounter. As these prerequisites are fulfilled within and between human beings who encounter each other, it is possible to speak of a space of togetherness, a mutual existence, where life's mystery shines forth and caring is realized. The challenge lies in creating these encounters within nursing care. © 2012 The Authors Scandinavian Journal of Caring Sciences © 2012 Nordic College of Caring Science.

  11. Orbital Perturbations of the Galilean Satellites During Planetary Encounters

    CERN Document Server

    Deienno, R; Vokrouhlicky, D; Yokoyama, T

    2014-01-01

    The Nice model of the dynamical instability and migration of the giant planets can explain many properties of the present Solar System, and can be used to constrain its early architecture. In the jumping-Jupiter version of the Nice model, required from the terrestrial planet constraint and dynamical structure of the asteroid belt, Jupiter has encounters with an ice giant. Here we study the survival of the Galilean satellites in the jumping-Jupiter model. This is an important concern because the ice-giant encounters, if deep enough, could dynamically perturb the orbits of the Galilean satellites, and lead to implausible results. We performed numerical integrations where we tracked the effect of planetary encounters on the Galilean moons. We considered three instability cases from Nesvorny & Morbidelli (2012) that differed in the number and distribution of encounters. We found that in one case, where the number of close encounters was relatively small, the Galilean satellite orbits were not significantly af...

  12. Modelling soil-plant-atmosphere interactions by coupling the regional weather model WRF to mechanistic plant models

    Science.gov (United States)

    Klein, C.; Hoffmann, P.; Priesack, E.

    2012-04-01

    Climate change causes altering distributions of meteorological factors influencing plant growth and its interactions between the land surface and the atmosphere. Recent studies show, that uncertainties in regional and global climate simulations are also caused by lacking descriptions of the soil-plant-atmosphere system. Therefore, we couple a mechanistic soil-plant model to a regional climate and forecast model. The detailed simulation of the water and energy exchanges, especially the transpiration of grassland and forests stands, are the key features of the modelling framework. The Weather Research and Forecasting model (WRF) (Skamarock 2008) is an open source mesoscale numerical weather prediction model. The WRF model was modified in a way, to either choose its native, static land surface model NOAH or the mechanistic eco-system model Expert-N 5.0 individually for every single grid point within the simulation domain. The Expert-N 5.0 modelling framework provides a highly modular structure, enabling the development and use of a large variety of different plant and soil models, including heat transfer, nitrogen uptake/turnover/transport as well as water uptake/transport and crop management. To represent the key landuse types grassland and forest, we selected two mechanistic plant models: The Hurley Pasture model (Thornley 1998) and a modified TREEDYN3 forest simulation model (Bossel 1996). The models simulate plant growth, water, nitrogen and carbon flows for grassland and forest stands. A mosaic approach enables Expert-N to use high resolution land use data e.g. CORINE Land Cover data (CLC, 2006) for the simulation, making it possible to simulate different land use distributions within a single grid cell. The coupling results are analyzed for plausibility and compared with the results of the default land surface model NOAH (Fei Chen and Jimy Dudhia 2010). We show differences between the mechanistic and the static model coupling, with focus on the feedback effects

  13. Determinants of frequency and longevity of hospital encounters' data use

    Directory of Open Access Journals (Sweden)

    Wyatt Jeremy C

    2010-03-01

    Full Text Available Abstract Background The identification of clinically relevant information enables improvement in user interfaces and in data management. However, it is difficult to identify what information is important in daily clinical care, and what is used occasionally. This study aims to determine for how long clinical documents are used in a Hospital Information System (HIS. Methods The access logs of 3 years of usage of a HIS were analysed concerning report departmental source, type of hospital encounter, and inpatient encounter ICD-9-CM main diagnosis. Reports median life indicates the median time elapsed between information creation and its usage. The models that better explains report views over time were explored. Results The number of report views in the study period was 656 583. Fifty two percent of the reports viewed by medical doctors in emergency encounters were from previous encounters - 21% at outpatient attendance, 19% in inpatient (wards and 12% during emergency encounters. In an inpatient setting, 20% of the reports viewed were produced in previous encounters. The median life of information in documents is 1.5 days for emergency, 4.8 days for inpatient and 37.8 days for outpatient encounters. Immune-haemotherapy reports reach their median lives faster (7 days than clinical pathology (15 days, gastroenterology (80 days and pathology (118 days. The median life of reports produced in inpatient encounters varied from 36 days for neoplasms as the main diagnosis to 0.7 days for injury and poisoning. The model with the best fit (R2 > 0.9 was the exponential. Conclusions The usage of past patient information varied significantly according to patient age, type of information, type of hospital encounter and medical cause (main diagnosis for the encounter. The exponential model is a good fit to model how the reports are seen over time, so the design of user interfaces and repository management algorithms should take it in consideration.

  14. Global and regional effects of land-use change on climate in 21st century simulations with interactive carbon cycle

    Directory of Open Access Journals (Sweden)

    L. R. Boysen

    2014-04-01

    Full Text Available Biogeophysical (BGP and biogeochemical (BGC effects of land-use and land cover change (LULCC are separated at the global and regional scales in new interactive CO2 simulations for the 21st century. Results from four Earth System models (ESMs are analyzed for the future RCP8.5 scenario from simulations with and without land-use and land cover change (LULCC contributing to the Land-Use and Climate, IDentification of robust impacts (LUCID project. Over the period, 2006–2100, LULCC causes the atmospheric CO2 concentration to increase by 12, 22, and 66 ppm in CanESM2, MIROC-ESM, and MPI-ESM-LR, respectively. Statistically significant changes in global near-surface temperature are found in three models with a BGC-induced global mean annual warming between 0.07 and 0.23 K. BGP-induced responses are simulated by three models in areas of intense LULCC of varying sign and magnitude (between −0.47 and 0.10 K. Global land carbon losses due to LULCC are simulated by all models: 218, 57, 35 and 34 Gt C by MPI-ESM-LR, MIROC-ESM, IPSL-CM5A-LR and CanESM2, respectively. On the contrary, the CO2-fertilization effect caused by elevated atmospheric CO2 concentrations due to LULCC leads to a land carbon gain of 39 Gt C in MPI-ESM-LR and is almost negligible in the other models. A substantial part of the spread in models' responses to LULCC is attributed to the differences in implementation of LULCC (e.g. whether pastures or crops are simulated explicitly and the simulation of specific processes. Simple idealized experiments with clear protocols for implementing LULCC in ESMs are needed to increase the understanding of model responses and the statistical significance of results, especially, when analyzing the regional-scale impacts of LULCC.

  15. Multiple, distant (40°) in situ observations of a magnetic cloud and a corotating interaction region complex

    Science.gov (United States)

    Farrugia, C. J.; Berdichevsky, D. B.; Möstl, C.; Galvin, A. B.; Leitner, M.; Popecki, M. A.; Simunac, K. D. C.; Opitz, A.; Lavraud, B.; Ogilvie, K. W.; Veronig, A. M.; Temmer, M.; Luhmann, J. G.; Sauvaud, J. A.

    2011-06-01

    We report a comprehensive analysis of in situ observations made by Wind and the STEREO probes (STA, STB) of a complex interaction between a magnetic cloud (MC) and a corotating interaction region (CIR) occurring near the heliospheric current sheet (HCS) on November 19-21, 2007. The probes were separated by 0.7 AU (˜40∘) with a spread in heliographic latitudes (4.8,° 2.2,° and -0.4,° for STB, Wind and STA, respectively). We employ data from the MFI, SWE and 3DP instruments on Wind, and the PLASTIC and IMPACT suites on STEREO. STB, located east of Earth, observed a forward shock followed by signatures of a MC. The MC took the role of the HCS in that the polarity of the interplanetary magnetic field (IMF) on exit was the reverse of that on entry. A passage through a plasma sheet was observed. Along the Sun-Earth line Wind observed a stream interface (SI) between a forward and a reverse shock. A MC, compressed by the CIR, was entrained in this. STA, located 20° to the west of Earth, saw a MC which was not preceded by a shock. A SI trailed the transient. The shocks are examined using various methods and from this it is concluded that the forward shock at Wind—but not at STB—was driven by the MC. Examining the MC by Grad-Shafranov reconstruction, we find evidence of a double-flux rope structure at Wind and STA and possibly also at STB. The orientations are at variance with the notion of a large-scale flux tube being observed at the three spacecraft. We find consistency of this with the directional properties of the solar wind "strahl" electrons. We examine aspects of the geomagnetic response and find a double-dip storm corresponding to the two interplanetary triggers. The minimum Dst phase was prolonged and the geoeffects were intensified due to the interaction. We conclude that while the formation of compound streams is a common feature of interplanetary space, understanding their components when CIRs are involved is a complicated matter needing numerical

  16. Multiple, Distant (40 deg) in situ Observations of a Magnetic Cloud and a Corotating Interaction Region Complex

    Science.gov (United States)

    Farrugia, C. J.; Berdichevsky, D. B.; Moestl, C.; Galvin, A. B.; Leitner, M.; Popecki, M.; Simunac, K. D.; Opitz, A.; Lavraud, B.; Ogilvie, K.; Veronig, A.; Temmer, M.; Luhmann, J. G.; Sauvaud, J.

    2010-12-01

    We report a comprehensive analysis of in situ observations made by Wind and the STEREO probes (STA, STB) of a complex interaction between a magnetic cloud (MC) and a corotating interaction region (CIR) occurring near the heliospheric current sheet (HCS) on November 19-21, 2007. The probes were separated by 0.7 AU (~40 deg) with a spread in heliographic latitudes (4.8, 2.2, and -0.4 deg for STB, Wind and STA, respectively). We employ data from the MFI, SWE and 3DP instruments on Wind, and the PLASTIC and IMPACT suites on STEREO. STB, located east of Earth, observed a forward shock followed by signatures of a MC. The MC took the role of the HCS in that the polarity of the interplanetary magnetic field (IMF) on exit was the reverse of that on entry. A passage through a plasma sheet is observed. Along the Sun-Earth line Wind observed a stream interface (SI) between a forward and a reverse shock. A MC, compressed by the CIR, was entrained in this. STA, located 20 deg to the west of Earth, saw a MC which was not preceded by a shock. A SI trailed the transient. The shocks are examined using various methods and from this it is concluded that the forward shock at Wind - but not at STB - was driven by the MC. Examining the MC by Grad-Shafranov reconstruction, we find evidence of a double-flux rope structure at Wind and STA and possibly also at STB. The orientations are at variance with the notion of a large-scale flux tube being observed at the three spacecraft. We find consistency of this with the directional properties of the solar wind "strahl" electrons. We examine aspects of the geomagnetic response and find a double-dip storm corresponding to the two interplanetary triggers. The minimum Dst phase was prolonged and the geoffects were intensified due to the interaction. We conclude that while the formation of compound streams is a common feature of interplanetary space, understanding their components when CIRs are involved is a complicated matter needing numerical

  17. Nanoparticles and amyloid systems: A fatal encounter?

    Energy Technology Data Exchange (ETDEWEB)

    Abel, Bernd [Leibniz Institute of Surface Modification, Chemical Department, Permoserstr. 15, D-04318 Leipzig, Germany and Wilhelm-Ostwald-Institute for Physical and Theoretical Chemistry, Linnéstr. 3, D-04103 Leipzig (Germany)

    2014-10-06

    Nanoparticles (NPs) are used in many products of our daily life, however, there has been concern that they may also be harmful to human health. Recently NPs have been found to accelerate the fibrillation kinetics of amyloid systems. In the past this has been preliminarily attributed to a nucleation effect. Nanoparticle surfaces and interfaces appear to limit the degrees of freedom of amyloid systems (i.e., peptides and proteins) due to a phase space constraint such that rapid cross-beta structures are formed faster than without interface interactions and in turn fibril formation is enhanced significantly. Here we explore if lipid bilayers in the form of liposomes (140nm) also accelerate fibril formation for amyloid systems. We have investigated a fragment NNFGAIL of the Human islet amyloid polypeptide (hIAPP) in contact with 1,2-diphytanoyl-sn-glycero-3-phosphocholine (DPhPC) liposomes in aqueous solution. We found that the lipid bilayer vesicles do accelerate fibril formation in time-resolved off-line detected atomic force microscopy experiments. Characteristic Thioflavine-T fluorescence on the same structures verify that the structures consist of aggregated peptides in a typical cross-β-structure arrangement.

  18. An Intimate Encounter: Negotiating Subtitled Cinema

    Directory of Open Access Journals (Sweden)

    Niall Flynn

    2016-01-01

    Full Text Available The question of subtitling has received little attention in Film Studies, despite being the primary means by which foreign-language cinema is experienced. Current literature focuses on important matters of language and translation, but there are other aspects that exceed these matters when we watch subtitled films, aspects which are able to affect and move viewers without relying on explanation through translation. My paper shows how viewers have to negotiate these affective elements in order to apprehend foreign-language films, with special attention on their indeterminate characteristics that escape representation. It considers the negotiation of subtitled cinema from numerous theoretical perspectives. Gilles Deleuze’s film-philosophy is popular in Film Studies for its theoretical flows and lines of flight, but this paper engages another Deleuzian thread—one of gaps and fissure—in order to explore the indeterminate negotiations of subtitled films. But in thinking about subtitling, we also have to reconsider the constitution of media. Cinema is not just made up of individual parts; rather, it is made of many interacting media, which cannot be separated. I argue that subtitled cinema consists of multiple affective elements that go beyond the interpretive methods of language and translation, and that the practice of negotiation is one way to apprehend them. In conclusion, this article, by exploring non-linguistic issues, argues that subtitling is not simply supplementary to cinema.

  19. Suprathermal helium in corotating interaction regions: combined observations from SOHO/CELIAS/STOF and ACE/SWICS

    Science.gov (United States)

    Yu, J.; Berger, L.; Wimmer-Schweingruber, R.; Bochsler, P.; Klecker, B.; Hilchenbach, M.; Kallenbach, R.

    2017-02-01

    Context. Energetic particle enhancements that are associated with corotating interaction regions (CIRs) are typically believed to arise from the sunward propagation of particles that are accelerated by CIR-driven shocks beyond 1 AU. It is expected that these sunward-travelling particles will lose energy and scatter, resulting in a turnover of the energy spectra below 0.5 MeV/nuc. However, the turnover has not been observed so far, suggesting that the CIR-associated low-energy suprathermal ions are accelerated locally close to the observer. Aims: We investigate the variability of suprathermal particle spectra from CIR to CIR as well as their evolution and variation as the observer moves away from the rear shock or wave. Methods: Helium data in the suprathermal energy range from the Solar and Heliospheric Observatory/Charge, Element, and Isotope Analysis System/Suprathermal Time-of-Flight (SOHO/CELIAS/STOF) were used for the spectral analysis and were combined with data from the Advanced Composition Explorer/ Solar Wind Ion Composition Spectrometer (ACE/SWICS) in the solar wind energies. Results: We investigated sixteen events: nine clean CIR events, three CIR events with possible contamination from upstream ion events or solar energetic particles (SEPs), and four events that occurred during CIR periods that were dominated by SEPs. Six of the nine clean CIR events showed possible signs of a turnover between 10-40 keV/nuc in the fast solar wind that trails the compression regions. Three of them even showed this behaviour inside the compressed fast wind. The turnover part of the spectra became flatter and shifted from lower to higher energies with increasing connection distance to the reverse shock. The remaining three clean events showed continuous power-law spectra in both the compressed fast wind and fast wind regions, that is, the same behaviour as reported from previous observations. The spectra of the seven remaining events are more variable, that is, they show

  20. Transformative Theatre: A Promising Educational Tool for Improving Health Encounters With LGBT Older Adults.

    Science.gov (United States)

    Hughes, Anne K; Luz, Clare; Hall, Dennis; Gardner, Penny; Hennessey, Chris Walker; Lammers, Lynn

    2016-01-01

    Lesbian, gay, bisexual, or transgender (LGBT) older adults are often unaware or fearful of aging services that contribute to greater vulnerability, isolation, and risk when services are needed. In addition, they may perceive or experience bias in health care encounters. Providers may not recognize their own biases or their impact on such encounters. In response, a group of LGBT community activists, aging professionals, researchers, and a theatre ensemble developed an interactive theatre experience, described herein, that portrays challenges faced by LGBT older adults needing services. Goals included raising awareness among LGBT older adults and providers about issues such as the limited legal rights of partners, limited family support, and fear of being mistreated as a result of homophobia. Evaluations and feedback reflected the potential of interactive theatre to engage people in sensitive discussions that can lead to increased awareness, reduced bias, practice change, and ultimately improved care for LGBT older adults.

  1. Influence of fault geometry and fault interaction on strain partitioning within western Sichuan and its adjacent region

    Institute of Scientific and Technical Information of China (English)

    2010-01-01

    There are several major active fault zones in the western Sichuan and its vicinity. Slip rates and seismicity vary on different fault zones. For example, slip rates on the Xianshuihe fault zone are higher than 10 mm/a. Its seismicity is also intense. Slip rates on the Longmenshan fault zone are low. However, Wenchuan Ms8.0 earthquake occurred on this fault zone in 2008. Here we study the impact of fault geometry on strain partitioning in the western Sichuan region using a three-dimensional viscoe- lastoplastic model. We conclude that the slip partitioning on the Xianshuihe-Xiaojiang fault presents as segmented, and it is related to fault geometry and fault structure. Slip rate is high on fault segment with simple geometry and structure, and vice versa. Strain rate outside the fault is localized around the fault segment with complex geometry and fault structure. Strain partitioning on the central section of the Xianshuihe-Xiaojiang fault zone is influenced by the interaction between the Anninghe-Zemuhe fault and the Daliangshan fault zone. Striking of the Longmenshan fault zone is nearly orthogonal to the direction of eastward extrusion in the Tibetan Plateau. It leads to low slip rate on the fault zone.

  2. Genetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.

    Science.gov (United States)

    Bacíková, Dagmar; Horowitz, David S

    2005-03-01

    Both the Prp18 protein and the U5 snRNA function in the second step of pre-mRNA splicing. We identified suppressors of mutant prp18 alleles in the gene for the U5 snRNA (SNR7). The suppressors' U5 snRNAs have either a U4-to-A or an A8-to-C mutation in the evolutionarily invariant loop 1 of U5. Suppression is specific for prp18 alleles that encode proteins with mutations in a highly conserved region of Prp18 which forms an unstructured loop in crystals of Prp18. The snr7 suppressors partly restored the pre-mRNA splicing activity that was lost in the prp18 mutants. The close functional relationship of Prp18 and U5 is emphasized by the finding that two snr7 alleles, U5A and U6A, are dominant synthetic lethal with prp18 alleles. Our results support the idea that Prp18 and the U5 snRNA act in concert during the second step of pre-mRNA splicing and suggest a model in which the conserved loop of Prp18 acts to stabilize the interaction of loop 1 of the U5 snRNA with the splicing intermediates.

  3. CARE-HHH-APD Workshop on Interaction Regions for the LHC Upgrade, DAFNE, and SuperB

    CERN Document Server

    Zimmermann, Frank; IR'07; IR 2007

    2008-01-01

    This report contains the Proceedings of the CARE-HHH-APD Mini-Workshop “IR’07,” which was held in Frascati, Italy, from 7 to 9 November 2007. The central theme of the IR’07 Mini-Workshop was the upgrade of the LHC interaction region (IR). A second topic was the experience with the upgraded DAFNE IR as well as the ongoing plans and studies for SuperB, plus possible applications of crab-waist collisions for the LHC upgrade. Discussions during the workshop addressed the performance and limitations of the IR-upgrade optics performance, the optimization of new LHC triplet magnets, the US-LARP magnet strategy (response to Lucio Rossi’s “challenge”), heat deposition, earlyseparation dipoles, detector-integrated quadrupoles, strategy for crab cavities, beam–beam wire compensators, and crab-waist collisions. At IR’07 all auxiliary systems, e.g. wires and crab cavities, received a strong boost. Energy deposition was shown to add an important criterion to the optics requirements—in a first attempt a ...

  4. Impact of SDS surfactant on the interactions of Cu(2+) ions with the amyloidogenic region of human prion protein.

    Science.gov (United States)

    Hecel, Aleksandra; Migliorini, Caterina; Valensin, Daniela; Luczkowski, Marek; Kozlowski, Henryk

    2015-08-01

    Prion diseases, known as Transmissible Spongiform Encephalopathies (TSEs), are a group of fatal neuronal, and to some extent infectious disorders, associated with a pathogenic protein agent called prion protein (PrP). The human prion protein (hPrP) fragment encompassing the 91-127 region, also known as the amyloidogenic domain, comprises two copper-binding sites corresponding to His-96 and His-111 residues that act as anchors for Cu(2+) binding. In this work, we investigated Cu(2+) interaction with hPrP91-127 in the presence of the anionic surfactant sodium dodecyl sulfate (SDS), which induces a partial α-helix folding of the peptide. Our data indicate that the Cu(2+) coordination ability of the amyloidogenic fragment in the presence of SDS micelles is significantly different to that observed in aqueous solution. This is mainly due to the fact that SDS micelles strongly stabilize the formation of the α-helical structure of the peptide backbone, which is well conserved also upon Cu(2+) binding, contrary to the random coil conformation mainly assumed by hPrP91-127 in aqueous solutions. Potentiometric and spectroscopic studies clearly indicate that in the case of SDS containing solutions, Cu(2+) ions coordinate simultaneously to both imidazoles, while in the case of water solutions, metal ion coordination involves only a single His side chain, which individually acts as an independent Cu(2+) anchoring site.

  5. Spatial fingerprints of community structure in human interaction network for an extensive set of large-scale regions.

    Directory of Open Access Journals (Sweden)

    Zsófia Kallus

    Full Text Available Human interaction networks inferred from country-wide telephone activity recordings were recently used to redraw political maps by projecting their topological partitions into geographical space. The results showed remarkable spatial cohesiveness of the network communities and a significant overlap between the redrawn and the administrative borders. Here we present a similar analysis based on one of the most popular online social networks represented by the ties between more than 5.8 million of its geo-located users. The worldwide coverage of their measured activity allowed us to analyze the large-scale regional subgraphs of entire continents and an extensive set of examples for single countries. We present results for North and South America, Europe and Asia. In our analysis we used the well-established method of modularity clustering after an aggregation of the individual links into a weighted graph connecting equal-area geographical pixels. Our results show fingerprints of both of the opposing forces of dividing local conflicts and of uniting cross-cultural trends of globalization.

  6. Reproductive encounters: Negev bedouin women’s lay encounters at childbirth in an Israeli hospital

    NARCIS (Netherlands)

    S. Kisch

    2009-01-01

    Though hospital studies have often focused on the vertical relationships between patients and medical staff, the interactions between patients have received much less attention. Whereas interaction with staff members is episodic, patients often spend long hours sharing intimate space and daily routi

  7. Social encounter networks: characterizing Great Britain.

    Science.gov (United States)

    Danon, Leon; Read, Jonathan M; House, Thomas A; Vernon, Matthew C; Keeling, Matt J

    2013-08-22

    A major goal of infectious disease epidemiology is to understand and predict the spread of infections within human populations, with the intention of better informing decisions regarding control and intervention. However, the development of fully mechanistic models of transmission requires a quantitative understanding of social interactions and collective properties of social networks. We performed a cross-sectional study of the social contacts on given days for more than 5000 respondents in England, Scotland and Wales, through postal and online survey methods. The survey was designed to elicit detailed and previously unreported measures of the immediate social network of participants relevant to infection spread. Here, we describe individual-level contact patterns, focusing on the range of heterogeneity observed and discuss the correlations between contact patterns and other socio-demographic factors. We find that the distribution of the number of contacts approximates a power-law distribution, but postulate that total contact time (which has a shorter-tailed distribution) is more epidemiologically relevant. We observe that children, public-sector and healthcare workers have the highest number of total contact hours and are therefore most likely to catch and transmit infectious disease. Our study also quantifies the transitive connections made between an individual's contacts (or clustering); this is a key structural characteristic of social networks with important implications for disease transmission and control efficacy. Respondents' networks exhibit high levels of clustering, which varies across social settings and increases with duration, frequency of contact and distance from home. Finally, we discuss the implications of these findings for the transmission and control of pathogens spread through close contact.

  8. PROTECT: Proximity-based Trust-advisor using Encounters for Mobile Societies

    OpenAIRE

    Kumar, Udayan; Thakur, Gautam; Helmy, Ahmed

    2010-01-01

    Many interactions between network users rely on trust, which is becoming particularly important given the security breaches in the Internet today. These problems are further exacerbated by the dynamics in wireless mobile networks. In this paper we address the issue of trust advisory and establishment in mobile networks, with application to ad hoc networks, including DTNs. We utilize encounters in mobile societies in novel ways, noticing that mobility provides opportunities to build proximity,...

  9. A computational approach identifies two regions of Hepatitis C Virus E1 protein as interacting domains involved in viral fusion process.

    Science.gov (United States)

    Bruni, Roberto; Costantino, Angela; Tritarelli, Elena; Marcantonio, Cinzia; Ciccozzi, Massimo; Rapicetta, Maria; El Sawaf, Gamal; Giuliani, Alessandro; Ciccaglione, Anna Rita

    2009-07-29

    The E1 protein of Hepatitis C Virus (HCV) can be dissected into two distinct hydrophobic regions: a central domain containing an hypothetical fusion peptide (FP), and a C-terminal domain (CT) comprising two segments, a pre-anchor and a trans-membrane (TM) region. In the currently accepted model of the viral fusion process, the FP and the TM regions are considered to be closely juxtaposed in the post-fusion structure and their physical interaction cannot be excluded. In the present study, we took advantage of the natural sequence variability present among HCV strains to test, by purely sequence-based computational tools, the hypothesis that in this virus the fusion process involves the physical interaction of the FP and CT regions of E1. Two computational approaches were applied. The first one is based on the co-evolution paradigm of interacting peptides and consequently on the correlation between the distance matrices generated by the sequence alignment method applied to FP and CT primary structures, respectively. In spite of the relatively low random genetic drift between genotypes, co-evolution analysis of sequences from five HCV genotypes revealed a greater correlation between the FP and CT domains than respect to a control HCV sequence from Core protein, so giving a clear, albeit still inconclusive, support to the physical interaction hypothesis.The second approach relies upon a non-linear signal analysis method widely used in protein science called Recurrence Quantification Analysis (RQA). This method allows for a direct comparison of domains for the presence of common hydrophobicity patterns, on which the physical interaction is based upon. RQA greatly strengthened the reliability of the hypothesis by the scoring of a lot of cross-recurrences between FP and CT peptides hydrophobicity patterning largely outnumbering chance expectations and pointing to putative interaction sites. Intriguingly, mutations in the CT region of E1, reducing the fusion process in

  10. Value creation and knowledge development in tourism experience encounters

    DEFF Research Database (Denmark)

    Sørensen, Flemming; Jensen, Jens Friis

    2015-01-01

    It has been argued that service encounters between front-line employees and users support the development of knowledge about users' needs. However, the potential for this often remains unused, not least in tourism. This article argues that if tourism service encounters are changed into ‘experience...... encounters’ by integrating them into the tourism experience to which they are related, this will create added experiential value for tourists and increase the creation of knowledge about users. This is illustrated in an innovation field experiment in a retro design boutique hotel in which service encounters...

  11. Clinical teacher training--maximising the 'ad hoc' teaching encounter.

    Science.gov (United States)

    Molodysky, Eugen

    2007-12-01

    Classically, the patient is absent when the learner makes an 'ad hoc' corridor enquiry of their supervisor. This teaching encounter challenges the supervisor to ensure that the educational benefit is not limited by the brevity of the encounter. Focusing on some of the critical steps or teaching skills involved in the learning process increases the efficiency and effectiveness of this type of teaching encounter. Educationalists have provided models to optimise this fleeting corridor enquiry. This article presents a range of scripted clinical teaching scenarios that demonstrate the sound educational theory and principles underlying one such model--the 'one minute preceptor' or 'five step microskills model' of clinical teaching.

  12. Encountering Science in the World: New Partnerships for Science Interpretation

    Science.gov (United States)

    Chambers, L. H.; Davis, A.; Paglierani, R.

    2014-12-01

    In 2000, while visiting Arches National Park in Utah, I had my first encounter with my science in the context of interpretation. During a ranger walk, a student intern at the park explained the concept of the radiation budget (for the desert surface, in her case) to the group of visitors. As a NASA scientist on the Clouds and the Earth's Radiant Energy System (CERES) science team, a team whose entire focus is on understanding Earth's energy budget, that visit made quite an impression on me: here was my science connected to the immediate and personal experience of that desert environment in a way that even my then 4-year-old daughter could take something from. Some years later, when I was invited to speak to a group of interpreters through the NASA/National Park Service "Earth to Sky" project, I jumped at the chance. Since then, I have had several opportunities to interact with interpreters, through additional "Earth to Sky" workshops as well as during a meeting of the National Association for Interpretation in my hometown. While I was invited to speak to these groups as a subject matter expert, I always learned at least as much as they did from the interaction. The standard practice for Earth to Sky is to pair presenters with an interpreter coach to help fine-tune the presentation for the audience - a valuable practice for presentations to any audience, if one can find an appropriate coach. The mere idea that interpretation is a profession, with research and guidelines and best practices, was completely eye opening to me at one of my first Earth to Sky events. So how to leverage interpretation for science communication? Rather than expecting busy scientists to learn everything about interpretation, a more effective approach is likely the one taken in the Earth to Sky workshop series, where scientists and interpreters work together for an intensive period to share information and approaches, and the interpreters are then able to take appropriate science elements to

  13. An observational study of the relationship between precipitating ions and ENAs emerging from the ion/atmosphere interaction region

    Science.gov (United States)

    Mackler, David A.

    Plasmasheet particles transported Earthward during times of active magnetospheric convection can interact with thermospheric neutrals through charge exchange. The resulting Energetic Neutral Atoms (ENAs) are free to leave the influence of the magnetosphere and can be remotely detected. ENAs associated with low altitude (300--800 km) ion precipitation in the high latitude atmosphere/ionosphere are termed Low Altitude Emissions (LAEs). Remotely observed LAEs are highly non-isotropic in velocity space such that the pitch angle distribution at the time of charge exchange is near 90 degrees. The Geomagnetic Emission Cone (GEC) of LAEs can be mapped spatially, showing where proton energy is deposited during times of varying geomagnetic activity. In this study we present a statistical look at the correlation between LAE flux (intensity and location) and geomagnetic activity as well as comparisons of LAE signatures with in situ ion precipitation. The LAE data is from the MENA imager on the IMAGE satellite over the declining phase of solar cycle 23 (2000--2005). The SYM-H, AE, and Kp indices are used to describe geomagnetic activity. The in situ data is from the Defense Meteorological Satellite Program (DMSP). The goal of the study is to evaluate properties of LAEs in ENA images and determine if those images can be used to infer properties of ion precipitation. Results indicate a general positive correlation to LAE flux for all three indices, with the SYM-H showing the greatest non-linearity. The MLT distribution of LAEs are centered about midnight and spread with increasing activity. The Invariant Latitude for all indices has a slightly negative correlation. The combined results indicate that both LAE and DMSP data behave similarly to geomagnetic activity. LAEs are more spread out in latitude, possibly due to multiple charge exchange interactions, while the in situ data changes to lower latitudes dramatically with increasing flux. The bulk of the data indicates that the

  14. The standardized patient encounter: a dynamic educational approach to enhance students' clinical healthcare skills.

    Science.gov (United States)

    Herge, E Adel; Lorch, Arlene; Deangelis, Tina; Vause-Earland, Tracey; Mollo, Kimberly; Zapletal, Audrey

    2013-01-01

    Occupational therapy educators are challenged to prepare students entering the profession to be skilled in assessment, critical thinking, self-analysis, and decision-making. Simulation is an effective strategy used in medical and nursing curriculums to develop or enhance critical thinking, self-analysis, and decision-making skills. Through simulated learning activities, such as encounters with standardized patients (SP), students develop skills in decision-making, clinical reasoning, and interpersonal communication, skills necessary to function effectively in the current health care environment. This paper describes the process for integrating SP encounters in a professional healthcare curriculum for occupational therapy graduate students. Evidence that supports the use of simulation in healthcare curriculums for health profession students is explored. An example of an SP encounter in one occupational therapy course is described to illustrate how students engage in higher-level thinking as they administer an assessment tool and interact with an SP. The process of developing and evaluating the SP encounter is described and the outcomes are presented. The authors believe the SP experience is a viable teaching method in preparing competent, reflective practitioners for tomorrow's healthcare environment.

  15. Solar-wind turbulence and shear: a superposed-epoch analysis of corotating interaction regions at 1 AU

    Energy Technology Data Exchange (ETDEWEB)

    Borovsky, Joseph E [Los Alamos National Laboratory; Denton, Michael H [LANCASTER UNIV.

    2009-01-01

    A superposed-epoch analysis of ACE and OMNI2 measurements is performed on 27 corotating interaction regions (CIRs) in 2003-2008, with the zero epoch taken to be the stream interface as determined by the maximum of the plasma vorticity. The structure of CIRs is investigated. When the flow measurements are rotated into the local-Parker-spiral coordinate system the shear is seen to be abrupt and intense, with vorticities on the order of 10{sup -5}-10{sup -4} sec{sup -1}. Converging flows perpendicular to the stream interface are seen in the local-Parker-spiral coordinate system and about half of the CIRs show a layer of divergent rebound flow away from the stream interface. Arguments indicate that any spreading of turbulence away from the region where it is produced is limited to about 10{sup 6} km, which is very small compared with the thickness of a CrR. Analysis of the turbulence across the CrRs is performed. When possible, the effects of discontinuities are removed from the data. Fluctuation amplitudes, the Alfvenicity, and the level of Alfvenic correlations all vary smoothly across the CrR. The Alfven ratio exhibits a decrease at the shear zone of the stream interface. Fourier analysis of 4.5-hr subintervals of ACE data is performed and the results are superposed averaged as an ensemble of realizations. The spectral slopes of the velocity, magnetic-field, and total-energy fluctuations vary smoothly across the CIR. The total-energy spectral slope is {approx} 3/2 in the slow and fast wind and in the CrRs. Analysis of the Elsasser inward-outward fluctuations shows a smooth transition across the CrR from an inward-outward balance in the slow wind to an outward dominance in the fast wind. A number of signatures of turbulence driving at the shear zone are sought (entropy change, turbulence amplitude, Alfvenicity, Alfven ratio, spectral slopes, in-out nature): none show evidence of driving of turbulence by shear.

  16. Global and regional effects of land-use change on climate in 21st century simulations with interactive carbon cycle

    Directory of Open Access Journals (Sweden)

    L. R. Boysen

    2014-09-01

    Full Text Available Biogeophysical (BGP and biogeochemical (BGC effects of land-use and land cover change (LULCC are separated at the global and regional scales in new interactive CO2 simulations for the 21st century. Results from four earth system models (ESMs are analyzed for the future RCP8.5 scenario from simulations with and without land-use and land cover change (LULCC, contributing to the Land-Use and Climate, IDentification of robust impacts (LUCID project. Over the period 2006–2100, LULCC causes the atmospheric CO2 concentration to increase by 12, 22, and 66 ppm in CanESM2, MIROC-ESM, and MPI-ESM-LR, respectively. Statistically significant changes in global near-surface temperature are found in three models with a BGC-induced global mean annual warming between 0.07 and 0.23 K. BGP-induced responses are simulated by three models in areas of intense LULCC of varying sign and magnitude (between −0.47 and 0.10 K. Modifications of the land carbon pool by LULCC are disentangled in accordance with processes that can lead to increases and decreases in this carbon pool. Global land carbon losses due to LULCC are simulated by all models: 218, 57, 35 and 34 Gt C by MPI-ESM-LR, MIROC-ESM, IPSL-CM5A-LR and CanESM2, respectively. On the contrary, the CO2-fertilization effect caused by elevated atmospheric CO2 concentrations due to LULCC leads to a land carbon gain of 39 Gt C in MPI-ESM-LR and is almost negligible in the other models. A substantial part of the spread in models' responses to LULCC is attributed to the differences in implementation of LULCC (e.g., whether pastures or crops are simulated explicitly and the simulation of specific processes. Simple idealized experiments with clear protocols for implementing LULCC in ESMs are needed to increase the understanding of model responses and the statistical significance of results, especially when analyzing the regional-scale impacts of LULCC.

  17. Solar-wind turbulence and shear: a superposed-epoch analysis of corotating interaction regions at 1 AU

    Energy Technology Data Exchange (ETDEWEB)

    Borovsky, Joseph E [Los Alamos National Laboratory; Denton, Michael H [LANCASTER UNIV.

    2009-01-01

    A superposed-epoch analysis of ACE and OMNI2 measurements is performed on 27 corotating interaction regions (CIRs) in 2003-2008, with the zero epoch taken to be the stream interface as determined by the maximum of the plasma vorticity. The structure of CIRs is investigated. When the flow measurements are rotated into the local-Parker-spiral coordinate system the shear is seen to be abrupt and intense, with vorticities on the order of 10{sup -5}-10{sup -4} sec{sup -1}. Converging flows perpendicular to the stream interface are seen in the local-Parker-spiral coordinate system and about half of the CIRs show a layer of divergent rebound flow away from the stream interface. Arguments indicate that any spreading of turbulence away from the region where it is produced is limited to about 10{sup 6} km, which is very small compared with the thickness of a CrR. Analysis of the turbulence across the CrRs is performed. When possible, the effects of discontinuities are removed from the data. Fluctuation amplitudes, the Alfvenicity, and the level of Alfvenic correlations all vary smoothly across the CrR. The Alfven ratio exhibits a decrease at the shear zone of the stream interface. Fourier analysis of 4.5-hr subintervals of ACE data is performed and the results are superposed averaged as an ensemble of realizations. The spectral slopes of the velocity, magnetic-field, and total-energy fluctuations vary smoothly across the CIR. The total-energy spectral slope is {approx} 3/2 in the slow and fast wind and in the CrRs. Analysis of the Elsasser inward-outward fluctuations shows a smooth transition across the CrR from an inward-outward balance in the slow wind to an outward dominance in the fast wind. A number of signatures of turbulence driving at the shear zone are sought (entropy change, turbulence amplitude, Alfvenicity, Alfven ratio, spectral slopes, in-out nature): none show evidence of driving of turbulence by shear.

  18. Availability and Usability of BHO Encounter Data in MAX 2009

    Data.gov (United States)

    U.S. Department of Health & Human Services — Availability and Usability of Behavioral Health Organization Encounter Data in MAX 2009, published in Volume 4, Issue 2 of Medicare and Medicaid Research Review,...

  19. Assessing the Usability of MAX 2008 Encounter Data

    Data.gov (United States)

    U.S. Department of Health & Human Services — Assessing the Usability of MAX 2008 Encounter Data for Comprehensive Managed Care As growing numbers of Medicaid enrollees receive comprehensive health benefits...

  20. Storyboard GALILEO CRUISE SCIENCE OPPORTUNITIES describes asteroid encounters

    Science.gov (United States)

    1989-01-01

    Storyboard with mosaicked image of an asteroid and entitled GALILEO CRUISE SCIENCE OPPORTUNITIES describes asteroid objectives. These objectives include: first asteroid encounter; surface geology, composition size, shape, mass; and relation of primitive bodies to meteorites.

  1. The interaction between deepwater channel systems and growing thrusts and folds, toe-thrust region of the deepwater Niger Delta

    Science.gov (United States)

    Jolly, Byami; Whittaker, Alex; Lonergan, Lidia

    2015-04-01

    Gravity-driven seaward-verging thrusts, landward-verging back-thrusts and associated folds often characterize the slope and deepwater settings of passive margins. These structures, found in the 'toe-thrust' region of the system, exert a significant control on sediment gravity flows because they create and determine the location and configuration of sediment depocentres and transport systems. Consequently, a quantitative understanding of the interaction between sediment gravity flows and seabed topography is required to understand these systems effectively. Here we make quantitative measurements of the geomorphic response of submarine channels to growing tectonic structures with the aim of providing new constraints on the long-term erosional dynamics of submarine channel systems. This study exploits 3D seismic data in the outer toe-thrust region of the deepwater Niger Delta to analyze the interaction between Plio-Pleistocene channel systems and actively growing folds and thrusts. We mapped folds and thrusts from the seismic data and we used this data to reconstruct the history of fold growth. We then used the sea-bed seismic horizon to build a 50 m resolution Digital Elevation Model (DEM) of the sea floor in Arc-GIS. We extracted channel long- profiles across growing structures from the DEM, and made measurements of channel geometries at regular intervals along the channel length. This information was used to infer morphodyanamic processes that sculpted the channel systems through time, and to estimate the bed shear stresses and fluid velocities of typical flow events. The bathymetric long profiles of these channels are relatively linear with concavity that range from -0.08 to -0.34, and an average gradient of ~1o. Actively growing thrusts are typically associated with a local steepening in channel gradient by a factor of up to 3, and this effect extends 0.5 - 2 km upstream of the thrust. Within these knickzones, channel incision increases by approximately by a

  2. Opposing effects of D-cycloserine on fear despite a common extinction duration: interactions between brain regions and behavior.

    Science.gov (United States)

    Bolkan, Scott S; Lattal, K Matthew

    2014-09-01

    A number of studies have reported that D-cycloserine (DCS), a partial agonist of the N-methyl-D-aspartate glutamate receptor, can facilitate the loss of conditioned fear if it is administered during an extinction trial. Here we examine the effects of DCS injected into the hippocampus or amygdala on extinction of context-evoked freezing after contextual fear conditioning in C57BL/6 mice. We find that DCS administered prior to an extinction session decreased freezing from the outset of the session regardless of which brain region was targeted. Retention tests revealed opposite effects on fear expression despite identical behavioral treatments: intra-hippocampal DCS inhibited fear expression while intra-amygdala DCS potentiated fear expression. Following post-extinction session injections of DCS, we found a similar though less pronounced effect. Closer inspection of the data revealed that the effects of DCS interacted with the behavior of the subjects during extinction. Intra-hippocampal injections of DCS enhanced extinction in those mice that showed the greatest amount of within-session extinction, but had less pronounced effects on mice that showed the least within-session extinction. Intra-amygdala injections of DCS impaired extinction in those mice that showed the least within-session extinction, but there was some evidence that the effect in the amygdala did not depend on behavior during extinction. These findings demonstrate that even with identical extinction trial durations, the effects of DCS administered into the hippocampus and amygdala can heavily depend on the organism's behavior during the extinction session. The broader implication of these findings is that the effects of pharmacological treatments designed to enhance extinction by targeting hippocampal or amygdalar processes may depend on the responsivity of the subject to the behavioral treatment.

  3. Prospective Out-of-ecliptic White-light Imaging of Interplanetary Corotating Interaction Regions at Solar Maximum

    Science.gov (United States)

    Xiong, Ming; Davies, Jackie A.; Li, Bo; Yang, Liping; Liu, Ying D.; Xia, Lidong; Harrison, Richard A.; Keiji, Hayashi; Li, Huichao

    2017-07-01

    Interplanetary corotating interaction regions (CIRs) can be remotely imaged in white light (WL), as demonstrated by the Solar Mass Ejection Imager (SMEI) on board the Coriolis spacecraft and Heliospheric Imagers (HIs) on board the twin Solar TErrestrial RElations Observatory (STEREO) spacecraft. The interplanetary WL intensity, due to Thomson scattering of incident sunlight by free electrons, is jointly determined by the 3D distribution of electron number density and line-of-sight (LOS) weighting factors of the Thomson-scattering geometry. The 2D radiance patterns of CIRs in WL sky maps look very different from different 3D viewpoints. Because of the in-ecliptic locations of both the STEREO and Coriolis spacecraft, the longitudinal dimension of interplanetary CIRs has, up to now, always been integrated in WL imagery. To synthesize the WL radiance patterns of CIRs from an out-of-ecliptic (OOE) vantage point, we perform forward magnetohydrodynamic modeling of the 3D inner heliosphere during Carrington Rotation CR1967 at solar maximum. The mixing effects associated with viewing 3D CIRs are significantly minimized from an OOE viewpoint. Our forward modeling results demonstrate that OOE WL imaging from a latitude greater than 60° can (1) enable the garden-hose spiral morphology of CIRs to be readily resolved, (2) enable multiple coexisting CIRs to be differentiated, and (3) enable the continuous tracing of any interplanetary CIR back toward its coronal source. In particular, an OOE view in WL can reveal where nascent CIRs are formed in the extended corona and how these CIRs develop in interplanetary space. Therefore, a panoramic view from a suite of wide-field WL imagers in a solar polar orbit would be invaluable in unambiguously resolving the large-scale longitudinal structure of CIRs in the 3D inner heliosphere.

  4. Orbital perturbations of the Galilean satellites during planetary encounters

    Energy Technology Data Exchange (ETDEWEB)

    Deienno, Rogerio; Nesvorný, David [Southwest Research Institute, Boulder, CO (United States); Vokrouhlický, David [Institute of Astronomy, Charles University, Prague (Czech Republic); Yokoyama, Tadashi, E-mail: rogerio.deienno@gmail.com [Universidade Estadual Paulista, Rio Claro, SP (Brazil)

    2014-08-01

    The Nice model of the dynamical instability and migration of the giant planets can explain many properties of the present solar system, and can be used to constrain its early architecture. In the jumping-Jupiter version of the Nice model, required from the terrestrial planet constraint and dynamical structure of the asteroid belt, Jupiter has encounters with an ice giant. Here, we study the survival of the Galilean satellites in the jumping-Jupiter model. This is an important concern because the ice-giant encounters, if deep enough, could dynamically perturb the orbits of the Galilean satellites and lead to implausible results. We performed numerical integrations where we tracked the effect of planetary encounters on the Galilean moons. We considered three instability cases from Nesvorný and Morbidelli that differed in the number and distribution of encounters. We found that in one case, where the number of close encounters was relatively small, the Galilean satellite orbits were not significantly affected. In the other two, the orbital eccentricities of all moons were excited by encounters, Callisto's semimajor axis changed, and, in a large fraction of trials, the Laplace resonance of the inner three moons was disrupted. The subsequent evolution by tides damps eccentricities and can recapture the moons in the Laplace resonance. A more important constraint is represented by the orbital inclinations of the moons, which can be excited during the encounters and not appreciably damped by tides. We find that one instability case taken from Nesvorný and Morbidelli clearly does not meet this constraint. This shows how the regular satellites of Jupiter can be used to set limits on the properties of encounters in the jumping-Jupiter model, and help us to better understand how the early solar system evolved.

  5. Orbital Perturbations of the Galilean Satellites during Planetary Encounters

    Science.gov (United States)

    Deienno, Rogerio; Nesvorný, David; Vokrouhlický, David; Yokoyama, Tadashi

    2014-08-01

    The Nice model of the dynamical instability and migration of the giant planets can explain many properties of the present solar system, and can be used to constrain its early architecture. In the jumping-Jupiter version of the Nice model, required from the terrestrial planet constraint and dynamical structure of the asteroid belt, Jupiter has encounters with an ice giant. Here, we study the survival of the Galilean satellites in the jumping-Jupiter model. This is an important concern because the ice-giant encounters, if deep enough, could dynamically perturb the orbits of the Galilean satellites and lead to implausible results. We performed numerical integrations where we tracked the effect of planetary encounters on the Galilean moons. We considered three instability cases from Nesvorný & Morbidelli that differed in the number and distribution of encounters. We found that in one case, where the number of close encounters was relatively small, the Galilean satellite orbits were not significantly affected. In the other two, the orbital eccentricities of all moons were excited by encounters, Callisto's semimajor axis changed, and, in a large fraction of trials, the Laplace resonance of the inner three moons was disrupted. The subsequent evolution by tides damps eccentricities and can recapture the moons in the Laplace resonance. A more important constraint is represented by the orbital inclinations of the moons, which can be excited during the encounters and not appreciably damped by tides. We find that one instability case taken from Nesvorný & Morbidelli clearly does not meet this constraint. This shows how the regular satellites of Jupiter can be used to set limits on the properties of encounters in the jumping-Jupiter model, and help us to better understand how the early solar system evolved.

  6. Delaying the image : towards an aesthetics of encounter

    OpenAIRE

    Altés Arlandis, Alberto

    2016-01-01

    This thesis, as part of a movement towards the degree of PhD (a becoming Doctor of Philosophy), is constructed and approached as a philosophical situation, which is always about an encounter between terms that are foreign to each other. In this case, through the exploration of the interplays of space, film and politics, a multiplicity of foreign terms and such encounters will emerge and take us along a journey through places, movies and architectures, to discuss the ways in which architecture...

  7. Evidence for early stellar encounters in the orbital distribution of Edgeworth-Kuiper Belt objects

    CERN Document Server

    Ida, S; Burkert, A

    1999-01-01

    We have investigated effects of early stellar encounters on a protoplanetary disk (planetesimal disk) and found that they can explain the high eccentricities and inclinations observed in the outer part ($>42$AU) of the Edgeworth-Kuiper Belt (EKB). The proto-sun is considered as a member of a stellar aggregation that undergoes dissolution on a timescale $\\sim 10^8$yrs, such that a planetesimal disk experiences a flyby encounter at pericenter distance ($q$) on the order of 100AU. We simulated dynamical evolution of a planetesimal (test particle) disk perturbed by a passing star. We show that the stellar encounter pumps the velocity dispersion in the disk in the outer parts ($> 0.25q$). Planet formation is forestalled in that region. We also find that a stellar encounter with pericenter distance $q \\sim 100-200$AU could have pumped up the velocity dispersion of EKB objects outside 42AU to the observed magnitude while preserving that inside Neptune's 3:2 mean-motion resonance (located at 39.5AU), which allows for...

  8. Earth encounters as the origin of fresh surfaces on near-Earth asteroids.

    Science.gov (United States)

    Binzel, Richard P; Morbidelli, Alessandro; Merouane, Sihane; Demeo, Francesca E; Birlan, Mirel; Vernazza, Pierre; Thomas, Cristina A; Rivkin, Andrew S; Bus, Schelte J; Tokunaga, Alan T

    2010-01-21

    Telescopic measurements of asteroids' colours rarely match laboratory reflectance spectra of meteorites owing to a 'space weathering' process that rapidly reddens asteroid surfaces in less than 10(6) years. 'Unweathered' asteroids (those having spectra matching the most commonly falling ordinary chondrite meteorites), however, are seen among small bodies the orbits of which cross inside Mars and the Earth. Various explanations have been proposed for the origin of these fresh surface colours, ranging from collisions to planetary encounters. Less reddened asteroids seem to cross most deeply into the terrestrial planet region, strengthening the evidence for the planetary-encounter theory, but encounter details within 10(6) years remain to be shown. Here we report that asteroids displaying unweathered spectra (so-called 'Q-types') have experienced orbital intersections closer than the Earth-Moon distance within the past 5 x 10(5) years. These Q-type asteroids are not currently found among asteroids showing no evidence of recent close planetary encounters. Our results substantiate previous work: tidal stress, strong enough to disturb and expose unweathered surface grains, is the most likely dominant short-term asteroid resurfacing process. Although the seismology details are yet to be worked out, the identification of rapid physical processes that can produce both fresh and weathered asteroid surfaces resolves the decades-long puzzle of the difference in colour of asteroids and meteorites.

  9. Releasing and relieving encounters: experiences of pregnancy and childbirth.

    Science.gov (United States)

    Lundgren, Ingela

    2004-12-01

    The experience of childbirth is an important life event for women, memories of which may follow them throughout life. The aim of the study reported here was to synthesize the results from four selected studies describing these experiences by focusing on women's and midwives' experiences of the encounter during childbirth, as well as experiences of pregnancy from the women's perspective. The setting was the Alternative Birth Care Centre (Sahlgrenska University Hospital, Goteborg) and Karolinska Hospital (Stockholm, Sweden). A qualitative method grounded in phenomenology and hermeneutics was used as a basis for the studies and synthesis. The essential structure may be conceptualized under the heading 'releasing and relieving encounters', which, for the woman, constitutes an encounter with herself as well as with the midwife, and includes stillness as well as change. Stillness is expressed as presence and being one's body. Change is expressed as transition to the unknown and to motherhood. In the releasing and relieving encounter, for the midwife stillness and change equals being both anchored and a companion. To be a companion is to be an available person who listens to and follows the woman through the process of childbirth. To be anchored is to be the person who respects the limits of the woman's ability as well as her own professional limits in the transition process. A releasing and relieving encounter implies a sharing of responsibility and participation for women. This may be understood as a unique feature, which differs from other caring encounters and should be further studied.

  10. Emotions in relation to healthcare encounters affecting self-esteem.

    Science.gov (United States)

    Räty, Lena; Gustafsson, Barbro

    2006-02-01

    This study identifies emotions in patients with epilepsy as a result of confirming and disconfirming healthcare experiences. A discussion of emotions as a motive for patients' goal-directed actions was a further aim of this study. The critical incident method was used for data collection. Emotions occurring in confirming and disconfirming healthcare encounters were analyzed using the Belief-Desire Theory of Emotions and were categorized as basic, complex, or self-evaluating. Confirming encounters aroused emotions like hope, a feeling of security, joy, relief, and pride, while disconfirming encounters aroused emotions like despair, fear, unrest, resignation, shame, and guilt. The emotions identified in the healthcare encounters were recognized as motives for action. An emotion such as a feeling of security aroused a desire in the patients to strengthen their positive self and motivated them to have a constructive and sympathetic attitude toward the healthcare experience. An emotion such as anger caused patients to strive to maintain their self-respect either by avoiding difficult situations and ignoring the problem (patients with a low self-esteem) or by trying to re-create a positive self-image (patients with a high self-esteem). Healthcare encounters between patient and caregiver considerably affect the patient's emotional status and thereby his or her well-being. The importance of establishing healthcare encounters that evoke positive emotions that strengthen patients' resources must be addressed in future nursing care.

  11. Finding the imprints of stellar encounters in long period comets

    CERN Document Server

    Feng, Fabo

    2015-01-01

    The solar system's Oort cloud can be perturbed by the Galactic tide and by individual passing stars. These perturbations can inject Oort cloud objects into the inner parts of the solar system, where they may be observed as the long-period comets (periods longer than 200 years). Using dynamical simulations of the Oort cloud under the perturbing effects of the tide and 61 known stellar encounters, we investigate the link between long-period comets and encounters. We find that past encounters were responsible for injecting at least 5% of the currently known long-period comets. This is a lower limit due to the incompleteness of known encounters. Although the Galactic tide seems to play the dominant role in producing the observed long-period comets, the non-uniform longitude distribution of the cometary perihelia suggests the existence of strong -- but as yet unidentified -- stellar encounters or other impulses. The strongest individual future and past encounters are probably HIP 89825 (Gliese 710) and HIP 14473, ...

  12. Activation of G Protein-Coupled Receptor Kinase 1 Involves Interactions between Its N-Terminal Region and Its Kinase Domain

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Chih-chin; Orban, Tivadar; Jastrzebska, Beata; Palczewski, Krzysztof; Tesmer, John J.G. (Case Western); (Michigan)

    2012-03-16

    G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors (GPCRs) to initiate receptor desensitization. In addition to the canonical phosphoacceptor site of the kinase domain, activated receptors bind to a distinct docking site that confers higher affinity and activates GRKs allosterically. Recent mutagenesis and structural studies support a model in which receptor docking activates a GRK by stabilizing the interaction of its 20-amino acid N-terminal region with the kinase domain. This interaction in turn stabilizes a closed, more active conformation of the enzyme. To investigate the importance of this interaction for the process of GRK activation, we first validated the functionality of the N-terminal region in rhodopsin kinase (GRK1) by site-directed mutagenesis and then introduced a disulfide bond to cross-link the N-terminal region of GRK1 with its specific binding site on the kinase domain. Characterization of the kinetic and biophysical properties of the cross-linked protein showed that disulfide bond formation greatly enhances the catalytic efficiency of the peptide phosphorylation, but receptor-dependent phosphorylation, Meta II stabilization, and inhibition of transducin activation were unaffected. These data indicate that the interaction of the N-terminal region with the kinase domain is important for GRK activation but does not dictate the affinity of GRKs for activated receptors.

  13. The proline-histidine-rich CDK2/CDK4 interaction region of C/EBPalpha is dispensable for C/EBPalpha-mediated growth regulation in vivo

    DEFF Research Database (Denmark)

    Porse, Bo Torben; Pedersen, Thomas Askov; Hasemann, Marie Sigurd

    2006-01-01

    that a short, centrally located, 15-amino-acid proline-histidine-rich region (PHR) of C/EBPalpha is responsible for the growth-inhibitory function of the protein through its ability to interact with CDK2 and CDK4, thereby inhibiting their activities. Homozygous Cebpa(DeltaPHR/DeltaPHR) (DeltaPHR) mice...

  14. A Cross-cultural Corpus of Annotated Verbal and Nonverbal Behaviors in Receptionist Encounters

    CERN Document Server

    Makatchev, Maxim; Sakr, Majd

    2012-01-01

    We present the first annotated corpus of nonverbal behaviors in receptionist interactions, and the first nonverbal corpus (excluding the original video and audio data) of service encounters freely available online. Native speakers of American English and Arabic participated in a naturalistic role play at reception desks of university buildings in Doha, Qatar and Pittsburgh, USA. Their manually annotated nonverbal behaviors include gaze direction, hand and head gestures, torso positions, and facial expressions. We discuss possible uses of the corpus and envision it to become a useful tool for the human-robot interaction community.

  15. Affinity modification of EcoRII DNA methyltransferase by the dialdehyde-substituted DNA duplexes: mapping the enzyme region that interacts with DNA.

    Science.gov (United States)

    Gritsenko, Oksana M; Koudan, Elizaveta V; Mikhailov, Sergey N; Ermolinsky, Boris S; Van Aerschot, Arthur; Herdewijn, Piet; Gromova, Elizaveta S

    2002-01-01

    Affinity modification of EcoRII DNA methyltransferase (M x EcoRII) by DNA duplexes containing oxidized 2'-O-beta-D-ribofuranosylcytidine (Crib*) or 1-(beta-D-galactopyranosyl)thymine (Tgal*) residues was performed. Cross-linking yields do not change irrespective of whether active Crib* replaces an outer or an inner (target) deoxycytidine within the EcoRII recognition site. Chemical hydrolysis of M x EcoRII in the covalent cross-linked complex with the Tgal*-substituted DNA indicates the region Gly268-Met391 of the methylase that is likely to interact with the DNA sugar-phosphate backbone. Both specific and non-specific DNA interact with the same M x EcoRII region. Our results support the theoretically predicted DNA binding region of M x EcoRII.

  16. Major Geomagnetic Storms (Dst less than or equal to -100 nT) Generated by Corotating Interaction Regions

    Science.gov (United States)

    Richardson, I. G.; Webb, D. F.; Zhang, J.; Berdichevsky, B. D.; Biesecker, D. A.; Kasper, J. C.; Kataoka, R.; Steinberg, J. T.; Thompson, B. J.; Wu, C.-C.; Zhukov, A. N.

    2006-01-01

    Seventy-nine major geomagnetic storms (minimum Dst less than or equal to -100 nT) observed in 1996 to 2004 were the focus of a Living with a Star Coordinated Data-Analysis Workshop (CDAW) in March, 2005. In 9 cases, the storm driver appears to have been purely a corotating interaction region (CIR) without any contribution from coronal mass ejection-related material (interplanetary coronal mass ejections, ICMEs). These storms were generated by structures within CIRs located both before and/or after the stream interface that included persistently southward magnetic fields for intervals of several hours. We compare their geomagnetic effects with those of 159 CIRs observed during 1996 - 2005. The major storms form the extreme tail of a continuous distribution of CIR geoeffectiveness which peaks at Dst approx. -40 nT but is subject to a prominent seasonal variation of - 40 nT which is ordered by the spring and fall equinoxes and the solar wind magnetic field direction towards or away from the Sun. The O'Brien and McPherron [2000] equations, which estimate Dst by integrating the incident solar wind electric field and incorporating a ring current loss term, largely account for the variation in storm size. They tend to underestimate the size of the larger CIR-associated storms by Dst approx. 20 nT. This suggests that injection into the ring current may be more efficient than expected in such storms. Four of the nine major storms in 1996 - 2004 occurred during a period of less than three solar rotations in September - November, 2002, also the time of maximum mean IMF and solar magnetic field intensity during the current solar cycle. The maximum CIR-storm strength found in our sample of events, plus additional 23 probable CIR-associated Dst less than or equal to -100 nT storms in 1972 - 1995, is (Dst = -161 nT). This is consistent with the maximum storm strength (Dst approx. -180 nT) expected from the O'Brien and McPherron equations for the typical range of solar wind

  17. Development of prognostic aerosol–cloud interactions combining a chemistry transport model and a regional climate model

    Directory of Open Access Journals (Sweden)

    M. A. Thomas

    2015-02-01

    Full Text Available To reduce uncertainties and hence, to obtain a better estimate of aerosol (direct and indirect radiative forcing, next generation climate models aim for a tighter coupling between chemistry transport models and regional climate models and a better representation of aerosol–cloud interactions. In this study, this coupling is done by first forcing the Rossby Center regional climate model, RCA4 by ERA-Interim lateral boundaries (LBCs and SST using the standard CDNC (cloud droplet number concentration formulation (hereafter, referred to as the "stand-alone RCA4 version" or "CTRL" simulation. In this simulation, the CDNCs are assigned fixed numbers based on if the underlying surface is land or oceanic. The meteorology from this simulation is then used to drive the chemistry transport model, MATCH which is coupled online with the aerosol dynamics model, SALSA. CDNC fields obtained from MATCH-SALSA are then fed back into a new RCA4 simulation. In this new simulation (referred to as "MOD" simulation, all parameters remain the same as in the first run except for the CDNCs provided by MATCH-SALSA. Simulations are carried out with this model set up for the period 2005–2012 over Europe and the differences in cloud microphysical properties and radiative fluxes as a result of local CDNC changes and possible model responses are analyzed. Our study shows substantial improvements in the cloud microphysical properties with the input of the MATCH-SALSA derived 3-D CDNCs compared to the stand-alone RCA4 version. This model set up improves the spatial, seasonal and vertical distribution of CDNCs with higher concentration observed over central Europe during summer half of the year and over Eastern Europe and Russia during the winter half of the year. Realistic cloud droplet radii (CD radii values have been simulated with the maxima reaching 13 μm whereas in the stand-alone version, the values reached only 5 μm. A substantial improvement in the distribution of

  18. Exploring the Relation between the Degree of Novelty of Innovations and User-producer Interaction across Different Income Regions

    DEFF Research Database (Denmark)

    Harirchi, Gouya; Chaminade, Cristina

    2014-01-01

    User–producer interactions have been recognized as important for innovation. With the rapid growth of emerging economies’ markets, and an increasing degree of technological sophistication of both users and producers in those markets, user–producer interaction is becoming global. Using original firm...

  19. Gravitational Vortices And Clump Formation In Saturn's F ring During An Encounter With Prometheus

    Science.gov (United States)

    Sutton, Phil J.; Kusmartsev, Feodor V.

    2013-02-01

    Saturn rings are most beautiful and dynamic places in the solar system, consisting of ice particles in a constant battle between the gravitational forces of Saturn and its many moons. Fan, spiral, propellers, moonlets and streamer-channels observed by CASSINI in the F-ring have been attributed to encounters by Prometheus on the F ring, with investigations of optical thickness revealing large populations of transient moonlets. Taking into account gravitational interaction between particles and a multi-stranded F-ring structure we show that Prometheus' encounters create rotational flows, like atmospheric vortices and the self-gravity enhances the accelerated growth and size of moonlets. Vortex patches form caustics, which is a primary cause of the transient particle density clumps of 20 km width and 100 km length, and they are elongated to cover an area of 1600 km by 150 km, which may eventually combine into a vortex sheet.

  20. Gravitational vortices and clump formation in Saturn's F ring during an encounter with Prometheus.

    Science.gov (United States)

    Sutton, Phil J; Kusmartsev, Feodor V

    2013-01-01

    Saturn rings are most beautiful and dynamic places in the solar system, consisting of ice particles in a constant battle between the gravitational forces of Saturn and its many moons. Fan, spiral, propellers, moonlets and streamer-channels observed by CASSINI in the F-ring have been attributed to encounters by Prometheus on the F ring, with investigations of optical thickness revealing large populations of transient moonlets. Taking into account gravitational interaction between particles and a multi-stranded F-ring structure we show that Prometheus' encounters create rotational flows, like atmospheric vortices and the self-gravity enhances the accelerated growth and size of moonlets. Vortex patches form caustics, which is a primary cause of the transient particle density clumps of 20 km width and 100 km length, and they are elongated to cover an area of 1600 km by 150 km, which may eventually combine into a vortex sheet.