Refining teacher design capacity: mathematics teachers' interactions with digital curriculum resources

NARCIS (Netherlands)

Pepin, B.; Gueudet, G.; Trouche, L.

2017-01-01

The goal of this conceptual paper is to develop enhanced understandings of mathematics teacher design and design capacity when interacting with digital curriculum resources. We argue that digital resources in particular offer incentives and increasing opportunities for mathematics teachers’ design,

Design, Synthesis and Evaluation of 2,5-Diketopiperazines as Inhibitors of the MDM2-p53 Interaction.

Directory of Open Access Journals (Sweden)

Mariell Pettersson

Full Text Available The transcription factor p53 is the main tumour suppressor in cells and many cancer types have p53 mutations resulting in a loss of its function. In tumours that retain wild-type p53 function, p53 activity is down-regulated by MDM2 (human murine double minute 2 via a direct protein-protein interaction. We have designed and synthesised two series of 2,5-diketopiperazines as inhibitors of the MDM2-p53 interaction. The first set was designed to directly mimic the α-helical region of the p53 peptide, containing key residues in the i, i+4 and i+7 positions of a natural α-helix. Conformational analysis indicated that 1,3,6-trisubstituted 2,5-diketopiperazines were able to place substituents in the same spatial orientation as an α-helix template. The key step of the synthesis involved the cyclisation of substituted dipeptides. The other set of tetrasubstituted 2,5-diketopiperazines were designed based on structure-based docking studies and the Ugi multicomponent reaction was used for the synthesis. This latter set comprised the most potent inhibitors which displayed micromolar IC50-values in a biochemical fluorescence polarisation assay.

Interactive Genetic Algorithm - An Adaptive and Interactive Decision Support Framework for Design of Optimal Groundwater Monitoring Plans

Science.gov (United States)

Babbar-Sebens, M.; Minsker, B. S.

2006-12-01

In the water resources management field, decision making encompasses many kinds of engineering, social, and economic constraints and objectives. Representing all of these problem dependant criteria through models (analytical or numerical) and various formulations (e.g., objectives, constraints, etc.) within an optimization- simulation system can be a very non-trivial issue. Most models and formulations utilized for discerning desirable traits in a solution can only approximate the decision maker's (DM) true preference criteria, and they often fail to consider important qualitative and incomputable phenomena related to the management problem. In our research, we have proposed novel decision support frameworks that allow DMs to actively participate in the optimization process. The DMs explicitly indicate their true preferences based on their subjective criteria and the results of various simulation models and formulations. The feedback from the DMs is then used to guide the search process towards solutions that are "all-rounders" from the perspective of the DM. The two main research questions explored in this work are: a) Does interaction between the optimization algorithm and a DM assist the system in searching for groundwater monitoring designs that are robust from the DM's perspective?, and b) How can an interactive search process be made more effective when human factors, such as human fatigue and cognitive learning processes, affect the performance of the algorithm? The application of these frameworks on a real-world groundwater long-term monitoring (LTM) case study in Michigan highlighted the following salient advantages: a) in contrast to the non-interactive optimization methodology, the proposed interactive frameworks were able to identify low cost monitoring designs whose interpolation maps respected the expected spatial distribution of the contaminants, b) for many same-cost designs, the interactive methodologies were able to propose multiple alternatives

Mapping Cultural Frame Shifting in Interaction Design with Blending Theory

DEFF Research Database (Denmark)

Markussen, Thomas; Krogh, Peter Gall

2008-01-01

In this paper, we introduce Gilles Fauconnier & Mark Turner's blending theory as a new conceptual framework for explaining ‘cultural frame shifting' in interaction design. Cultural frame shifting is when people, through their explorative use of technology, are required imaginatively to reorganize...... their cultural background knowledge and expectations. In current HCI research it has occasionally been pointed out that a proper understanding of this phenomenon hinges on addressing the relationship between embodied interaction and cultural meaning construction as part of a larger interactive system. However...... the network model of mental spaces from Fauconnier & Turner's blending theory onto video material and interviews from initial qualitative use studies of a design case. In so doing we explore and argue for how meaning formation and embodied cognition coalesce in cultural frame shifting and provide a tool...

Vibrational Markovian modelling of footprints after the interaction of antibiotics with the packaging region of HIV type 1.

Science.gov (United States)

Díaz, Humberto González; de Armas, Ronal Ramos; Molina, Reinaldo

2003-11-01

The design of novel anti-HIV compounds has now become a crucial area for scientists working in numerous interrelated fields of science such as molecular biology, medicinal chemistry, mathematical biology, molecular modelling and bioinformatics. In this context, the development of simple but physically meaningful mathematical models to represent the interaction between anti-HIV drugs and their biological targets is of major interest. One such area currently under investigation involves the targets in the HIV-RNA-packaging region. In the work described here, we applied Markov chain theory in an attempt to describe the interaction between the antibiotic paromomycin and the packaging region of the RNA in Type-1 HIV. In this model, a nucleic acid squeezed graph is used. The vertices of the graph represent the nucleotides while the edges are the phosphodiester bonds. A stochastic (Markovian) matrix was subsequently defined on this graph, an operation that codifies the probabilities of interaction between specific nucleotides of HIV-RNA and the antibiotic. The strength of these local interactions can be calculated through an inelastic vibrational model. The successive power of this matrix codifies the probabilities with which the vibrations after drug-RNA interactions vanish along the polynucleotide main chain. The sums of self-return probabilities in the k-vicinity of each nucleotide represent physically meaningful descriptors. A linear discriminant function was developed and gave rise to excellent discrimination in 80.8% of interacting and footprinted nucleotides. The Jackknife method was employed to assess the stability and predictability of the model. On the other hand, a linear regression model predicted the local binding affinity constants between a specific nucleotide and the antibiotic (R(2)=0.91, Q(2)=0.86). These kinds of models could play an important role either in the discovery of new anti-HIV compounds or the study of their mode of action.

Designing Smart Artifacts for Adaptive Mediation of Social Viscosity: Triadic Actor-Network Enactments as a Basis for Interaction Design

Science.gov (United States)

Salamanca, Juan

2012-01-01

With the advent of ubiquitous computing, interaction design has broadened its object of inquiry into how smart computational artifacts inconspicuously act in people's everyday lives. Although user-centered design approaches remains useful for exploring how people cope with interactive systems, they cannot explain how this new breed of…

Configuration interaction calculations for the region of 76Ge

Science.gov (United States)

Brown, Alex

2017-09-01

I will present a short history of the configuration interaction Hamiltonians that have been developed for the (0f5 / 2 , 1p3 / 2 , 1p1 / 2 , 0g9 / 2) (jj 44) model space. This model space is appropriate for the region of nuclei bounded by the nickel isotopes for Z = 28 and the isotones with N = 50 . I will discuss results for the double-beta decay of 76Ge that lies in the jj 44 region. I will show results for the structure of nuclei around 76Ge for some selected data from gamma decay, Gamow-Teller beta decay, charge-exchange reactions, one-nucleon transfer reactions, and two-nucleon transfer reactions. This work was supported by NSF Grant PHY-1404442.

Building interactive simulations in a Web page design program.

Science.gov (United States)

Kootsey, J Mailen; Siriphongs, Daniel; McAuley, Grant

2004-01-01

A new Web software architecture, NumberLinX (NLX), has been integrated into a commercial Web design program to produce a drag-and-drop environment for building interactive simulations. NLX is a library of reusable objects written in Java, including input, output, calculation, and control objects. The NLX objects were added to the palette of available objects in the Web design program to be selected and dropped on a page. Inserting an object in a Web page is accomplished by adding a template block of HTML code to the page file. HTML parameters in the block must be set to user-supplied values, so the HTML code is generated dynamically, based on user entries in a popup form. Implementing the object inspector for each object permits the user to edit object attributes in a form window. Except for model definition, the combination of the NLX architecture and the Web design program permits construction of interactive simulation pages without writing or inspecting code.

The Impact of Social Interaction and Communications on Innovation in the Architectural Design Studio

Directory of Open Access Journals (Sweden)

Bhzad Sidawi

2012-07-01

Full Text Available Design is a social phenomenon and researchers suggest that social interaction, negotiations and communication between designers are essential to initiate creativity. Within the design studio environment, a number of factors affect the healthy social interaction and design negotiations, such as the teaching style of tutors and the culture that governs a design studio’s environment. This may in turn affect the utilization of the outcome of negotiations in the design project. Design studio students from the third to fifth years at the College of Architecture, University of Dammam (UD, the Kingdom of Saudi Arabia (KSA, were surveyed to find out how far the design studio’s culture and communication would impact the production of innovative design projects. The results show that frequent communication and the establishment’s shared grounds are essential to develop knowledge and positively influence the design outcome. On the other hand, the research found that negative qualities on a personal level and on that of a design studio environment would hinder a student’s creativity. However, to develop students’ design/innovative abilities, the researcher recommends that certain measures should be considered. These would include transforming the design studio into an interactive and friendly learning environment, adjusting the teaching methodology, and developing interactive communication abilities of students and tutors.

Orifice design for the control of coupled region flow

International Nuclear Information System (INIS)

Atherton, R.; Spadaro, P.R.; Brummerhop, F.G.

1975-01-01

A fluid system arrangement for nuclear reactors is described comprising a triplate orifice apparatus which simultaneously controls core flow distribution, flow rate ratio between hydraulically coupled regions of the blanket and radial static pressure gradients entering and leaving the blanket fuel region. The design of the apparatus is based on the parameters of the diameter of the orifice holes, the friction factor, and expansion, contraction and turning pressure loss coefficients of the geometry of each orifice region. These above parameters are properly matched to provide the desired pressure drop, flow split and negligible cross flow at the interface of standard and power-flattened open lattice blanket regions. (U.S.)

Interaction systems design and the protocol- and middleware-centred paradigms in distributed application development

NARCIS (Netherlands)

Andrade Almeida, João; van Sinderen, Marten J.; Quartel, Dick; Ferreira Pires, Luis

2003-01-01

This paper aims at demonstrating the benefits and importance of interaction systems design in the development of distributed applications. We position interaction systems design with respect to two paradigms that have influenced the design of distributed applications: the middleware-centred and the

The Influence of Neonatal Nursery Design on Mothers' Interactions in the Nursery.

Science.gov (United States)

Jones, Liz; Peters, Kathryn; Rowe, Jennifer; Sheeran, Nicola

2016-01-01

This study examined the influence of neonatal nursery design on interactions between nurses and mothers of infants in the nursery. We used a natural quasi-experimental design, using semi-structured interviews and a structured measure of mothers' and nurses' perceptions of nursing care, to compare mothers (n=26 and n=40) and nurses (n=22 and n=29) in an open-bay (OB) nursery and a single family room (SFR) nursery. Thematic analysis was used to generate key themes from the interviews. Mothers and nurses in both nursery designs talked about Valuing interactions; the importance of interactions between mothers and nurses. Mothers and nurses described SFRs as providing a space, My/their room, which enhanced mothers' sense of control and connection with the infant. SFRs were also associated with Changing the norms of interactions with nurses and other mothers, which created challenges in the desired quantity and quality of interactions for mothers and nurses. Nurses in the SFR nursery also reported Enhanced interactions, including improved confidentiality and personalized communication. Mothers in the OB nursery reported more supportive mothering actions from nurses than mothers in the SFR nursery. Both mothers and nurses in the OB nursery also talked about Our nursery community, which captured the value of having other nurses and mothers in the rooms. Mothers and nurses perceived that the SFR nursery enhanced privacy and maternal closeness for mothers compared to the OB nursery. However, the SFR nursery design presented challenges to some interactions of value to nurses and mothers. Copyright © 2016 Elsevier Inc. All rights reserved.

AGILE, a tool for interactive lattice design

CERN Document Server

Bryant, P J

2000-01-01

AGILE is a program that works in the IBM-PC, MS-Windows environment and is dedicated to the interactive design of alternating-gradient lattices for synchrotrons and transfer lines. The program was originally intended as a teaching tool, but has been used mostly for professional design work and is subject to continuous development. It contains original algorithms for coupling, scattering and eddy currents, and some slightly unusual algorithms for off-axis orbits and space charge. There are also additional features such as engineering design aids, calculators for relativistic and synchrotron radiation parameters, expert routines for optimising slow extraction, fitting and matching, and the internal storage of constants for over 1000 stable and quasi-stable charged particles. The program is object-oriented and fully integrated into the Windows environment - it is not a shell. Apart from office work, AGILE is ideal for home use, design workshops and when travelling. It is particularly suited to practical problems...

The structure and institutions: a regional aspect of interaction in the economic system

Directory of Open Access Journals (Sweden)

Leonid Stepanovich Tarasevich

2014-09-01

Full Text Available In the article with the help of two-sector model of the economic system, the interaction of national and regional economy is investigated. This interaction is observed from the position of development of material structure and institutions. As the key structural parameter of an economy, the proportion between sector of excess resources and sector of scarce resources is taken. The situation when sector of excess resources prevails over sector of scarce resources forms structural conditions for the creation of the market institutions. If a sector of excess resources is smaller than a sector of scarce resources, the conditions for the emergence of institutions of government regulation are formed. Two cases are analyzed: the first one concerns the situation of a simple national economy consisting of 2 provisory regions. The second is the case of the national economy consisting of many regions. The authors show that material structure of a total combination of regions defines institutions of the market or state regulation for the national economy as a whole. The institutions formed at the level of the national economy, can support or resist the development of structure of the region. The conditions are observed under which united institutions of the national economy contradict a development of structure of the individual region.

Improving Magnet Designs With High and Low Field Regions

DEFF Research Database (Denmark)

Bjørk, Rasmus; Bahl, Christian Robert Haffenden; Smith, Anders

2011-01-01

A general scheme for increasing the difference in magnetic flux density between a high and a low magnetic field region by removing unnecessary magnet material is presented. This is important in, e.g., magnetic refrigeration where magnet arrays have to deliver high field regions in close proximity...... to low field regions. Also, a general way to replace magnet material with a high permeability soft magnetic material where appropriate is discussed. As an example, these schemes are applied to a two dimensional concentric Halbach cylinder design resulting in a reduction of the amount of magnet material...

The Study on Human-Computer Interaction Design Based on the Users’ Subconscious Behavior

Science.gov (United States)

Li, Lingyuan

2017-09-01

Human-computer interaction is human-centered. An excellent interaction design should focus on the study of user experience, which greatly comes from the consistence between design and human behavioral habit. However, users’ behavioral habits often result from subconsciousness. Therefore, it is smart to utilize users’ subconscious behavior to achieve design's intention and maximize the value of products’ functions, which gradually becomes a new trend in this field.

Designing for multi-user interaction in the home environment : Implementing social translucence

NARCIS (Netherlands)

Niemantsverdriet, K.; Broekhuijsen, M.J.; van Essen, H.A.; Eggen, J.H.

2016-01-01

Interfaces of interactive systems for domestic use are usually designed for individual interactions although these interactions influence multiple users. In order to prevent conflicts and unforeseen influences on others we propose to leverage the human ability to take each other into consideration

Intelligent adaptive systems an interaction-centered design perspective

CERN Document Server

Hou, Ming; Burns, Catherine

2014-01-01

A synthesis of recent research and developments on intelligent adaptive systems from the HF (human factors) and HCI (human-computer interaction) domains, this book provides integrated design guidance and recommendations for researchers and system developers. It addresses a recognized lack of integration between the HF and HCI research communities, which has led to inconsistencies between the research approaches adopted, and a lack of exploitation of research from one field by the other. The book establishes design guidance through the review of conceptual frameworks, analytical methodologies,

An improved method for pancreas segmentation using SLIC and interactive region merging

Science.gov (United States)

Zhang, Liyuan; Yang, Huamin; Shi, Weili; Miao, Yu; Li, Qingliang; He, Fei; He, Wei; Li, Yanfang; Zhang, Huimao; Mori, Kensaku; Jiang, Zhengang

2017-03-01

Considering the weak edges in pancreas segmentation, this paper proposes a new solution which integrates more features of CT images by combining SLIC superpixels and interactive region merging. In the proposed method, Mahalanobis distance is first utilized in SLIC method to generate better superpixel images. By extracting five texture features and one gray feature, the similarity measure between two superpixels becomes more reliable in interactive region merging. Furthermore, object edge blocks are accurately addressed by re-segmentation merging process. Applying the proposed method to four cases of abdominal CT images, we segment pancreatic tissues to verify the feasibility and effectiveness. The experimental results show that the proposed method can make segmentation accuracy increase to 92% on average. This study will boost the application process of pancreas segmentation for computer-aided diagnosis system.

Interactive computer graphics and its role in control system design of large space structures

Science.gov (United States)

Reddy, A. S. S. R.

1985-01-01

This paper attempts to show the relevance of interactive computer graphics in the design of control systems to maintain attitude and shape of large space structures to accomplish the required mission objectives. The typical phases of control system design, starting from the physical model such as modeling the dynamics, modal analysis, and control system design methodology are reviewed and the need of the interactive computer graphics is demonstrated. Typical constituent parts of large space structures such as free-free beams and free-free plates are used to demonstrate the complexity of the control system design and the effectiveness of the interactive computer graphics.

Emission-line diagnostics of nearby H II regions including interacting binary populations

Science.gov (United States)

Xiao, Lin; Stanway, Elizabeth R.; Eldridge, J. J.

2018-06-01

We present numerical models of the nebular emission from H II regions around young stellar populations over a range of compositions and ages. The synthetic stellar populations include both single stars and interacting binary stars. We compare these models to the observed emission lines of 254 H II regions of 13 nearby spiral galaxies and 21 dwarf galaxies drawn from archival data. The models are created using the combination of the BPASS (Binary Population and Spectral Synthesis) code with the photoionization code CLOUDY to study the differences caused by the inclusion of interacting binary stars in the stellar population. We obtain agreement with the observed emission line ratios from the nearby star-forming regions and discuss the effect of binary-star evolution pathways on the nebular ionization of H II regions. We find that at population ages above 10 Myr, single-star models rapidly decrease in flux and ionization strength, while binary-star models still produce strong flux and high [O III]/H β ratios. Our models can reproduce the metallicity of H II regions from spiral galaxies, but we find higher metallicities than previously estimated for the H II regions from dwarf galaxies. Comparing the equivalent width of H β emission between models and observations, we find that accounting for ionizing photon leakage can affect age estimates for H II regions. When it is included, the typical age derived for H II regions is 5 Myr from single-star models, and up to 10 Myr with binary-star models. This is due to the existence of binary-star evolution pathways, which produce more hot Wolf-Rayet and helium stars at older ages. For future reference, we calculate new BPASS binary maximal starburst lines as a function of metallicity, and for the total model population, and present these in Appendix A.

Pion-nucleon interactions in low energy region

International Nuclear Information System (INIS)

Hiroshige, Noboru; Tsujimura, Tadakuni.

1977-01-01

Pion-nucleon interactions in low energy region (below 320 MeV in kinetic energy) are investigated on the basis of the one-particle-exchange model. The model is directly compared with the experimental data, i.e., differential cross sections and recoil nucleon polarizations, since phase shifts have not been uniquely determined. It is shown that these experimental data can be well reproduced by taking account of N (nucleon), Δ 33 , N 11 , N 13 , rho, f 0 and S (scalar meson) in the intermediate state. Some comments are given on the coupling constants which are determined so as to minimize chi-squared value (chi 2 ). Our predicted phase shifts for s-, p- and d-waves are also compared with other authors'. (auth.)

Gender-specific spatial interactions on Dutch regional labour markets and the gender employment gap

NARCIS (Netherlands)

Noback, Inge; Broersma, Lourens; Van Dijk, Jouke

2013-01-01

Gender-specific spatial interactions on Dutch regional labour markets and the gender employment gap, Regional Studies. This paper analyses gender-specific employment rates and the gender employment gap in Dutch municipalities for 2002. The novelty of this analysis is that it takes into account the

Cross-cultural human-computer interaction and user experience design a semiotic perspective

CERN Document Server

Brejcha, Jan

2015-01-01

This book describes patterns of language and culture in human-computer interaction (HCI). Through numerous examples, it shows why these patterns matter and how to exploit them to design a better user experience (UX) with computer systems. It provides scientific information on the theoretical and practical areas of the interaction and communication design for research experts and industry practitioners and covers the latest research in semiotics and cultural studies, bringing a set of tools and methods to benefit the process of designing with the cultural background in mind.

Cross-talk studies between FCC-hh Experimental Interaction Regions

CERN Document Server

AUTHOR|(CDS)2081283; Seryi, Andrei; Appleby, Robert Barrie; Rafique, Haroon; Besana, Maria Ilaria

2017-01-01

Debris from 50 TeV proton-proton collisions at the main interaction point in the FCC-hh may contribute to the background in the subsequent detector. This cross-talk is of possible concern for the FCC-hh due to the high luminosity and energy of the collider. DPMJET-III is used as a collision debris generator in order to assess the muon cross-talk contribution. An analytical calculation of muon range in rock is performed. This is followed by a full Monte Carlo simulation using FLUKA, where the accelerator tunnel has been modelled. The muon cross talk between the adjacent interaction points is assessed and its implications for FCC-hh design are discussed.

Interaction between core analysis methodology and nuclear design: some PWR examples

International Nuclear Information System (INIS)

Rothleder, B.M.; Eich, W.J.

1982-01-01

The interaction between core analysis methodology and nuclear design is exemplified by PSEUDAX, a major improvement related to the Advanced Recycle methodology program (ARMP) computer code system, still undergoing development by the Electric Power Research Institute. The mechanism of this interaction is explored by relating several specific nulcear design changes to the demands placed by these changes on the ARMP system, and by examining the meeting of these demands, first within the standard ARMP methodology and then through augmentation of the standard methodology by development of PSEUDAX

Regional Design Approach in Designing Climatic Responsive Administrative Building in the 21st Century

Science.gov (United States)

Haja Bava Mohidin, Hazrina Binti; Ismail, Alice Sabrina

2015-01-01

The objective of this paper is to explicate on the study of modern administrative building in Malaysia which portrays regional design approach that conforms to the local context and climate by reviewing two case studies; Perdana Putra (1999) and former Prime Minister's Office (1967). This paper is significant because the country's stature and political statement was symbolized by administrative building as a national icon. In other words, it is also viewed as a cultural object that is closely tied to a particular social context and nation historical moment. Administrative building, therefore, may exhibit various meanings. This paper uses structuralism paradigm and semiotic principles as a methodological approach. This paper is of importance for practicing architects and society in the future as it offers new knowledge and understanding in identifying the suitable climatic consideration that may reflect regionalist design approach in modern administrative building. These elements then may be adopted in designing public buildings in the future with regional values that are important for expressing national culture to symbolize the identity of place and society as well as responsive to climate change.

LHC Interaction Region Upgrade Phase I

CERN Document Server

Ostojic, R

2009-01-01

The LHC is starting operation with beam in 2008. The primary goal of CERN and the LHC community is to ensure that the collider is operated efficiently, maximizing its physics reach, and to achieve the nominal performance in the shortest term. Since several years the community has been discussing the directions for upgrading the experiments, in particular ATLAS and CMS, the LHC machine and the CERN proton injector complex. A well substantiated and coherent scenario for the first phase of the upgrade, which is foreseen in 2013, is now approved by CERN Council. In this paper, we present the goals and the proposed conceptual solution for the Phase-I upgrade of the LHC interaction regions. This phase relies on the mature Nb-Ti superconducting magnet technology, with the target of increasing the luminosity by a factor of 2-3 with respect to the nominal luminosity of 1034 cm-2s-1, while maximising the use of the existing infrastructure.

OptMAVEn--a new framework for the de novo design of antibody variable region models targeting specific antigen epitopes.

Directory of Open Access Journals (Sweden)

Tong Li

Full Text Available Antibody-based therapeutics provides novel and efficacious treatments for a number of diseases. Traditional experimental approaches for designing therapeutic antibodies rely on raising antibodies against a target antigen in an immunized animal or directed evolution of antibodies with low affinity for the desired antigen. However, these methods remain time consuming, cannot target a specific epitope and do not lead to broad design principles informing other studies. Computational design methods can overcome some of these limitations by using biophysics models to rationally select antibody parts that maximize affinity for a target antigen epitope. This has been addressed to some extend by OptCDR for the design of complementary determining regions. Here, we extend this earlier contribution by addressing the de novo design of a model of the entire antibody variable region against a given antigen epitope while safeguarding for immunogenicity (Optimal Method for Antibody Variable region Engineering, OptMAVEn. OptMAVEn simulates in silico the in vivo steps of antibody generation and evolution, and is capable of capturing the critical structural features responsible for affinity maturation of antibodies. In addition, a humanization procedure was developed and incorporated into OptMAVEn to minimize the potential immunogenicity of the designed antibody models. As case studies, OptMAVEn was applied to design models of neutralizing antibodies targeting influenza hemagglutinin and HIV gp120. For both HA and gp120, novel computational antibody models with numerous interactions with their target epitopes were generated. The observed rates of mutations and types of amino acid changes during in silico affinity maturation are consistent with what has been observed during in vivo affinity maturation. The results demonstrate that OptMAVEn can efficiently generate diverse computational antibody models with both optimized binding affinity to antigens and reduced

Interaction Design in a Context of Rehabilitation

DEFF Research Database (Denmark)

Høgn, Pia; Lykke, Marianne; Missel, Pernille

2016-01-01

Information and communication technology(ICT) mediated learning processes for people suffering from aphasia after an acquired brain injury are a relatively uncovered area of research. Helmer-Nielsen et al. (2014)[1] report about projects that study the effect of ICT-mediated speech therapists...... suffering from aphasia, with the purpose of increasing their possibilities for living independent and active lives. In the project, we design a digital environment for communication and learning for people with aphasia who require special learning processes for rebuilding language after a brain injury...... of a combination of learning theory, theories on the brain function and human-computer interaction. The user study showed the needs for collaborative learning processes with communication and social interaction as their focus, tools to support multimodality expressions and customised teaching materials...

User-Centered Design for Interactive Maps: A Case Study in Crime Analysis

Directory of Open Access Journals (Sweden)

Robert E. Roth

2015-02-01

Full Text Available In this paper, we address the topic of user-centered design (UCD for cartography, GIScience, and visual analytics. Interactive maps are ubiquitous in modern society, yet they often fail to “work” as they could or should. UCD describes the process of ensuring interface success—map-based or otherwise—by gathering input and feedback from target users throughout the design and development of the interface. We contribute to the expanding literature on UCD for interactive maps in two ways. First, we synthesize core concepts on UCD from cartography and related fields, as well as offer new ideas, in order to organize existing frameworks and recommendations regarding the UCD of interactive maps. Second, we report on a case study UCD process for GeoVISTA CrimeViz, an interactive and web-based mapping application supporting visual analytics of criminal activity in space and time. The GeoVISTA CrimeViz concept and interface were improved iteratively by working through a series of user→utility→usability loops in which target users provided input and feedback on needs and designs (user, prompting revisions to the conceptualization and functional requirements of the interface (utility, and ultimately leading to new mockups and prototypes of the interface (usability for additional evaluation by target users (user… and so on. Together, the background review and case study offer guidance for applying UCD to interactive mapping projects, and demonstrate the benefit of including target users throughout design and development.

Seven-step problem-based learning in an interaction design course

DEFF Research Database (Denmark)

Schultz, Nette; Christensen, Hans Peter

2004-01-01

The objective in this paper is the implementation of the highly structured seven-step PBL procedure as part of the learning process in a human-computer interaction design course at the Technical University of Denmark, taking into account the common learning processes in PBL and the interaction de...... others in a single course. The evaluation results showed that the students definitely took a deep approach to learning, and indicated clearly that the students had obtained competences not only within the traditional HCI curriculum but also in terms of team-work skills.......The objective in this paper is the implementation of the highly structured seven-step PBL procedure as part of the learning process in a human-computer interaction design course at the Technical University of Denmark, taking into account the common learning processes in PBL and the interaction...... individual reports after each case in the PBL-process in order to explore the students’ inter- and intra-personal team skills development in the learning process. Different qualitative and quantitative evaluation methods have been used to obtain a thorough evaluation of PBL used as a learning method among...

13 CFR 304.1 - Designation of Economic Development Districts: Regional eligibility.

Science.gov (United States)

2010-01-01

... Development Districts: Regional eligibility. 304.1 Section 304.1 Business Credit and Assistance ECONOMIC DEVELOPMENT ADMINISTRATION, DEPARTMENT OF COMMERCE ECONOMIC DEVELOPMENT DISTRICTS § 304.1 Designation of Economic Development Districts: Regional eligibility. Upon the request of a District Organization (as...

Interactive design of probability density functions for shape grammars

KAUST Repository

Dang, Minh; Lienhard, Stefan; Ceylan, Duygu; Neubert, Boris; Wonka, Peter; Pauly, Mark

2015-01-01

A shape grammar defines a procedural shape space containing a variety of models of the same class, e.g. buildings, trees, furniture, airplanes, bikes, etc. We present a framework that enables a user to interactively design a probability density

Map-based mobile services design, interaction and usability

CERN Document Server

Meng, Liqiu; Winter, Stephan; Popovich, Vasily

2008-01-01

This book reports the newest research and technical achievements on the following theme blocks: Design of mobile map services and its constraints; Typology and usability of mobile map services; Visualization solutions on small displays for time-critical tasks; Mobile map users; Interaction and adaptation in mobile environments; and Applications of map-based mobile services.

Empowering Older Patients to Engage in Self Care: Designing an Interactive Robotic Device

Science.gov (United States)

Tiwari, Priyadarshi; Warren, Jim; Day, Karen

2011-01-01

Objectives: To develop and test an interactive robot mounted computing device to support medication management as an example of a complex self-care task in older adults. Method: A Grounded Theory (GT), Participatory Design (PD) approach was used within three Action Research (AR) cycles to understand design requirements and test the design configuration addressing the unique task requirements. Results: At the end of the first cycle a conceptual framework was evolved. The second cycle informed architecture and interface design. By the end of third cycle residents successfully interacted with the dialogue system and were generally satisfied with the robot. The results informed further refinement of the prototype. Conclusion: An interactive, touch screen based, robot-mounted information tool can be developed to support healthcare needs of older people. Qualitative methods such as the hybrid GT-PD-AR approach may be particularly helpful for innovating and articulating design requirements in challenging situations. PMID:22195203

The plasma-wall interaction region: a key low temperature plasma for controlled fusion

International Nuclear Information System (INIS)

Counsell, G F

2002-01-01

The plasma-wall interaction region of a fusion device provides the interface between the hot core plasma and the material surfaces. To obtain acceptably low levels of erosion from these surfaces requires most of the power leaving the core to be radiated. This is accomplished in existing devices by encouraging plasma detachment, in which the hot plasma arriving in the region is cooled by volume recombination and ion-neutral momentum transfer with a dense population of neutrals recycled from the surface. The result is a low temperature (1 eV e e >10 19 m -3 ) but weakly ionized (n 0 >10 20 m -3 , n e /n 0 <0.1) plasma found nowhere else in the fusion environment. This plasma provides many of the conditions found in industrial plasmas exploiting plasma chemistry and the presence of carbon in the region (in the form of carbon-fibre composite used in the plasma facing materials) can result in the formation of deposited hydrocarbon films. The plasma-wall interaction region is therefore among the most difficult in fusion to model, requiring an understanding of atomic, molecular and surface physics issues

DO COROTATING INTERACTION REGION ASSOCIATED SHOCKS SURVIVE WHEN THEY PROPAGATE INTO THE HELIOSHEATH?

International Nuclear Information System (INIS)

Provornikova, E.; Opher, M.; Izmodenov, V.; Toth, G.

2012-01-01

During the solar minimum at the distance of 42-52 AU from the Sun, Voyager 2 observed recurrent sharp, shock-like increases in the solar wind speed that look very much like forward shocks (Lazarus et al.). The shocks were produced by corotating interaction regions (CIRs) that originated near the Sun. After the termination shock (TS) crossing in 2007, Voyager 2 entered the heliosheath and has been observing the plasma emanated during the recent solar minima. Measurements show high variable flow, but there were no shocks detected in the heliosheath. When CIR-driven shocks propagate to the outer heliosphere, their structure changes due to collision and merging processes of CIRs. In this Letter, we explore an effect of the merging of CIRs on the structure of CIR-associated shocks. We use a three-dimensional MHD model to study the outward propagation of the shocks with characteristics similar to those observed by Voyager 2 at ∼45 AU (Lazarus et al. 1999). We show that due to merging of CIRs (1) reverse shocks disappear, (2) forward shocks become weaker due to interaction with rarefaction regions from preceding CIRs, and (3) forward shocks significantly weaken in the heliosheath. Merged CIRs produce compression regions in the heliosheath with small fluctuations of plasma parameters. Amplitudes of the fluctuations diminish as they propagate deeper in the sheath. We conclude that interaction of shocks and rarefaction regions could be one of the explanations, why shocks produced by CIRs are not observed in the heliosheath by Voyager 2 while they were frequently observed upstream the TS.

Using Social Media Sentiment Analysis for Interaction Design Choices

DEFF Research Database (Denmark)

McGuire, Mark; Kampf, Constance Elizabeth

2015-01-01

Social media analytics is an emerging skill for organizations. Currently, developers are exploring ways to create tools for simplifying social media analysis. These tools tend to focus on gathering data, and using systems to make it meaningful. However, we contend that making social media data...... meaningful is by nature a human-computer interaction problem. We examine this problem around the emerging field of sentiment analysis, exploring criteria for designing sentiment analysis systems based in Human Computer interaction, HCI. We contend that effective sentiment analysis affects audience analysis...

Visualisation and research strategy for computational spatial and structural design interaction

NARCIS (Netherlands)

Peeten, D.; Hofmeyer, H.; Thabet, W

2010-01-01

A research engine is under development for studying the interaction of spatial and structural design processes. The design processes are being implemented as two separate configurable transformation steps; a conversion step and an optimisation step. A significant part of the spatial-to-structural

Frequency domain design of gain scheduling control for large wind systems in full-load region

International Nuclear Information System (INIS)

Burlibaşa, A.; Ceangă, E.

2014-01-01

Highlights: • A large wind energy system, operating under full-load regime, is considered. • According to its particularities in frequency domain, control law design is provided. • These particularities are influenced by the interactions of wind–tower–blade ensemble. • Control low, within gain scheduling strategy, is achieved imposing stability reserve. • Supplementary a criterion, aimed at reducing mechanical loads, is imposed. - Abstract: The paper presents the issue of power control law synthesis, in the case of a large wind system that operates under full-load regime, based on dynamic properties details in frequency domain. Solving this problem involves two phases: the establishment of a linearized model as faithfully as possible in various operating points of the full-load region, and synthesis of the power controller, considered with classic structure, taking into account frequency particularities of the obtained linearized model. Obtained linear model of the controlled process is of order 16 and encloses subsystems for tower fore-aft oscillations damping, and for drive-train torsion oscillations damping. The designed controller contains a PI component and a lag compensator for dynamic correction at high frequencies. It is known that the main features of wind system dynamics generated by the interaction of wind–tower–blade ensemble cause a gap in the gain characteristic of the model and complex conjugate zeros, which can move between right and left half-planes, depending on the average wind speed value. Consequently, for control law synthesis an interactive frequency solution is adopted. This is “transparent” in relation to particularities induced by wind–tower–blade interaction. This solution allows evaluation of the extent to which control law is affected by the subsystem for tower oscillations damping. Given the strong dependence between the model and the mean wind speed value, a gain scheduling control law is designed. At

Strategic Mobility 21. Collaborative Regional Web Portal Design, Development and Documentation

National Research Council Canada - National Science Library

Mallon, Lawrence G; Carson, Steve

2007-01-01

...: a regional planning interface that makes data, models, and analyses available to all stakeholders in an interactive and configurable manner. An underlying theme of this report is the merging of Web 2.0 and knowledge management technologies with Service Oriented Architecture.

Regional Design Approach in Designing Climatic Responsive Administrative Building in the 21st Century

International Nuclear Information System (INIS)

Mohidin, Hazrina Binti Haja Bava; Ismail, Alice Sabrina

2015-01-01

The objective of this paper is to explicate on the study of modern administrative building in Malaysia which portrays regional design approach that conforms to the local context and climate by reviewing two case studies; Perdana Putra (1999) and former Prime Minister's Office (1967). This paper is significant because the country's stature and political statement was symbolized by administrative building as a national icon. In other words, it is also viewed as a cultural object that is closely tied to a particular social context and nation historical moment. Administrative building, therefore, may exhibit various meanings. This paper uses structuralism paradigm and semiotic principles as a methodological approach. This paper is of importance for practicing architects and society in the future as it offers new knowledge and understanding in identifying the suitable climatic consideration that may reflect regionalist design approach in modern administrative building. These elements then may be adopted in designing public buildings in the future with regional values that are important for expressing national culture to symbolize the identity of place and society as well as responsive to climate change

Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA

Directory of Open Access Journals (Sweden)

Li Deng

2016-01-01

Full Text Available In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method.

Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA.

Science.gov (United States)

Deng, Li; Wang, Guohua; Yu, Suihuai

2016-01-01

In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm) were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive characteristics were analyzed, and the layout principles of human-machine interaction interface were summarized as the constraints in layout design. Again, the expression form of fitness function, pheromone, and heuristic information for the layout optimization of cabin was studied. The layout design model of human-machine interaction interface was established based on GA-ACA. At last, a layout design system was developed based on this model. For validation, the human-machine interaction interface layout design of drilling rig control room was taken as an example, and the optimization result showed the feasibility and effectiveness of the proposed method.

Designing a Bioengine for Detection and Analysis of Base String on an Affected Sequence in High-Concentration Regions

Directory of Open Access Journals (Sweden)

Debnath Bhattacharyya

2013-01-01

Full Text Available We design an Algorithm for bioengine. As a program are enable optimal alignments searching between two sequences, the host sequence (normal plant as well as query sequence (virus. Searching for homologues has become a routine operation of biological sequences in 4 × 4 combination with different subsequence (word size. This program takes the advantage of the high degree of homology between such sequences to construct an alignment of the matching regions. There is a main aim which is to detect the overlapping reading frames. This program also enables to find out the highly infected colones selection highest matching region with minimum gap or mismatch zones and unique virus colones matches. This is a small, portable, interactive, front-end program intended to be used to find out the regions of matching between host sequence and query subsequences. All the operations are carried out in fraction of seconds, depending on the required task and on the sequence length.

Designing a Bioengine for Detection and Analysis of Base String on an Affected Sequence in High-Concentration Regions

Science.gov (United States)

Mandal, Bijoy Kumar; Kim, Tai-hoon

2013-01-01

We design an Algorithm for bioengine. As a program are enable optimal alignments searching between two sequences, the host sequence (normal plant) as well as query sequence (virus). Searching for homologues has become a routine operation of biological sequences in 4 × 4 combination with different subsequence (word size). This program takes the advantage of the high degree of homology between such sequences to construct an alignment of the matching regions. There is a main aim which is to detect the overlapping reading frames. This program also enables to find out the highly infected colones selection highest matching region with minimum gap or mismatch zones and unique virus colones matches. This is a small, portable, interactive, front-end program intended to be used to find out the regions of matching between host sequence and query subsequences. All the operations are carried out in fraction of seconds, depending on the required task and on the sequence length. PMID:24000321

Brain regions associated with the acquisition of conditioned place preference for cocaine vs. social interaction.

Science.gov (United States)

El Rawas, Rana; Klement, Sabine; Kummer, Kai K; Fritz, Michael; Dechant, Georg; Saria, Alois; Zernig, Gerald

2012-01-01

Positive social interaction could play an essential role in switching the preference of the substance dependent individual away from drug related activities. We have previously shown that conditioned place preference (CPP) for cocaine at the dose of 15 mg/kg and CPP for four 15-min episodes of social interaction were equally strong when rats were concurrently conditioned for place preference by pairing cocaine with one compartment and social interaction with the other. The aim of the present study was to investigate the differential activation of brain regions related to the reward circuitry after acquisition/expression of cocaine CPP or social interaction CPP. Our findings indicate that cocaine CPP and social interaction CPP activated almost the same brain regions. However, the granular insular cortex and the dorsal part of the agranular insular cortex were more activated after cocaine CPP, whereas the prelimbic cortex and the core subregion of the nucleus accumbens were more activated after social interaction CPP. These results suggest that the insular cortex appears to be potently activated after drug conditioning learning while activation of the prelimbic cortex-nucleus accumbens core projection seems to be preferentially involved in the conditioning to non-drug stimuli such as social interaction.

Combining ethnography and object-orientation for mobile interaction design

DEFF Research Database (Denmark)

Kjeldskov, Jesper; Stage, Jan

2012-01-01

There has been a lot of interest in ethnography within human–computer interaction over the last two decades, and its relevance within systems development is today beyond question. However, one of the challenges reported is that ethnography generates findings and knowledge with such contextual...... richness that it can be hard to transfer into system design. In the light of recent years' push for the use of ethnography within the area of mobile human–computer interaction, this challenge has resurfaced and is of renewed importance to the research field. In this article we describe an interdisciplinary...

The lignite industry and regional development. Interactions exemplified by the Rhenish mining area

International Nuclear Information System (INIS)

Kulik, Lars; Voigt, Jens

2013-01-01

Even in times of globalised markets, the German lignite industry retains its local and regional roots. Viewed against this background, the relationship between lignite industry and regional actors, and the interactions between the two play a major role in the perspectives for this branch of Germany's energy sector. Today, the links between the lignite industry and regional bodies are those of a partnership at eye-level. This type of relationship between the industry and regional actors has led to new forms and methods of cooperation at various levels. This is particularly evident in the efforts to re-shape the regional structure, develop the structure of townships and strengthen the economic structure with lignite playing an important role and new partners which are gaining in importance. (orig.)

Designing an Interactive Multimedia Environment for Learning and Aiding Troubleshooting

National Research Council Canada - National Science Library

Kolodner, Janet

1997-01-01

.... However troubleshooting is a complex process both to learn and perform. This report examines the prospects for designing an interactive learning environment that helps users acquire and engage in effective troubleshooting...

Growing grass: a smart material interactive display, design and construction history

NARCIS (Netherlands)

Minuto, A.; Nijholt, Antinus

2012-01-01

In this paper we will present the design process and development of "Follow the Grass", our smart material interactive pervasive display, with related technical detailed explanation. We will present the design steps and prototypes with instructions for the use of smart materials (NiTiNOL) to create

Analysis and design of hybrid electric regional turboprop aircraft

NARCIS (Netherlands)

Voskuijl, M.; van Bogaert, J.; Gangoli Rao, A.

2017-01-01

The potential environmental benefits of hybrid electric regional turboprop aircraft in terms of fuel consumption are investigated. Lithium–air batteries are used as energy source in combination with conventional fuel. A validated design and analysis framework is extended with sizing and analysis

Module discovery by exhaustive search for densely connected, co-expressed regions in biomolecular interaction networks.

Directory of Open Access Journals (Sweden)

Recep Colak

2010-10-01

Full Text Available Computational prediction of functionally related groups of genes (functional modules from large-scale data is an important issue in computational biology. Gene expression experiments and interaction networks are well studied large-scale data sources, available for many not yet exhaustively annotated organisms. It has been well established, when analyzing these two data sources jointly, modules are often reflected by highly interconnected (dense regions in the interaction networks whose participating genes are co-expressed. However, the tractability of the problem had remained unclear and methods by which to exhaustively search for such constellations had not been presented.We provide an algorithmic framework, referred to as Densely Connected Biclustering (DECOB, by which the aforementioned search problem becomes tractable. To benchmark the predictive power inherent to the approach, we computed all co-expressed, dense regions in physical protein and genetic interaction networks from human and yeast. An automatized filtering procedure reduces our output which results in smaller collections of modules, comparable to state-of-the-art approaches. Our results performed favorably in a fair benchmarking competition which adheres to standard criteria. We demonstrate the usefulness of an exhaustive module search, by using the unreduced output to more quickly perform GO term related function prediction tasks. We point out the advantages of our exhaustive output by predicting functional relationships using two examples.We demonstrate that the computation of all densely connected and co-expressed regions in interaction networks is an approach to module discovery of considerable value. Beyond confirming the well settled hypothesis that such co-expressed, densely connected interaction network regions reflect functional modules, we open up novel computational ways to comprehensively analyze the modular organization of an organism based on prevalent and largely

Module discovery by exhaustive search for densely connected, co-expressed regions in biomolecular interaction networks.

Science.gov (United States)

Colak, Recep; Moser, Flavia; Chu, Jeffrey Shih-Chieh; Schönhuth, Alexander; Chen, Nansheng; Ester, Martin

2010-10-25

Computational prediction of functionally related groups of genes (functional modules) from large-scale data is an important issue in computational biology. Gene expression experiments and interaction networks are well studied large-scale data sources, available for many not yet exhaustively annotated organisms. It has been well established, when analyzing these two data sources jointly, modules are often reflected by highly interconnected (dense) regions in the interaction networks whose participating genes are co-expressed. However, the tractability of the problem had remained unclear and methods by which to exhaustively search for such constellations had not been presented. We provide an algorithmic framework, referred to as Densely Connected Biclustering (DECOB), by which the aforementioned search problem becomes tractable. To benchmark the predictive power inherent to the approach, we computed all co-expressed, dense regions in physical protein and genetic interaction networks from human and yeast. An automatized filtering procedure reduces our output which results in smaller collections of modules, comparable to state-of-the-art approaches. Our results performed favorably in a fair benchmarking competition which adheres to standard criteria. We demonstrate the usefulness of an exhaustive module search, by using the unreduced output to more quickly perform GO term related function prediction tasks. We point out the advantages of our exhaustive output by predicting functional relationships using two examples. We demonstrate that the computation of all densely connected and co-expressed regions in interaction networks is an approach to module discovery of considerable value. Beyond confirming the well settled hypothesis that such co-expressed, densely connected interaction network regions reflect functional modules, we open up novel computational ways to comprehensively analyze the modular organization of an organism based on prevalent and largely available large

Distance Education for the Gifted and Talented: An Interactive Design Model.

Science.gov (United States)

McKinnon, David H.; Nolan, C. J. Patrick

1999-01-01

Discusses development of an Australian distance-education cosmology course that employs an interactive design model and an extensive communication system. The way the model is used to organized, sequence, and deliver the course is explained. Discussion addresses how the model might be used to design other courses. (Author/CR)

Interaction design challenges and solutions for ALMA operations monitoring and control

Science.gov (United States)

Pietriga, Emmanuel; Cubaud, Pierre; Schwarz, Joseph; Primet, Romain; Schilling, Marcus; Barkats, Denis; Barrios, Emilio; Vila Vilaro, Baltasar

2012-09-01

The ALMA radio-telescope, currently under construction in northern Chile, is a very advanced instrument that presents numerous challenges. From a software perspective, one critical issue is the design of graphical user interfaces for operations monitoring and control that scale to the complexity of the system and to the massive amounts of data users are faced with. Early experience operating the telescope with only a few antennas has shown that conventional user interface technologies are not adequate in this context. They consume too much screen real-estate, require many unnecessary interactions to access relevant information, and fail to provide operators and astronomers with a clear mental map of the instrument. They increase extraneous cognitive load, impeding tasks that call for quick diagnosis and action. To address this challenge, the ALMA software division adopted a user-centered design approach. For the last two years, astronomers, operators, software engineers and human-computer interaction researchers have been involved in participatory design workshops, with the aim of designing better user interfaces based on state-of-the-art visualization techniques. This paper describes the process that led to the development of those interface components and to a proposal for the science and operations console setup: brainstorming sessions, rapid prototyping, joint implementation work involving software engineers and human-computer interaction researchers, feedback collection from a broader range of users, further iterations and testing.

Designing interactive systems to support and augment creativity - a roadmap for research and design

DEFF Research Database (Denmark)

Dalsgaard, Peter; Halskov, Kim; Frich Pedersen, Jonas

2018-01-01

and developments, exemplary cases, and future initiatives to study and design systems and tools to augment creative practices. Participation in the workshop requires participants to contribute with a position paper on one of the above topics, and to read and comment on co-participants contributions before......The aims of the workshop are to examine and discuss the current state of research in designing interactive systems to support and augment creative work, and to outline a roadmap for future research initiatives. The workshop will explore methodological issues and approaches, overarching trends...

The Effectiveness of Using Interactive Multimedia in Improving the Concept of Fashion Design and Its Application in The Making of Digital Fashion Design

Science.gov (United States)

Wiana, W.

2018-02-01

This research is related to the effort to design a more representative learning system to improve the learning result of digital fashion design, through the development of interactive multimedia based on motion graphic. This research is aimed to know the effect of interactive multimedia application based on motion graphic to increase the mastery of the concept and skill of the students to making fashion designing in digital format. The research method used is quasi experiment with research design of Non-equivalent Control Group Design. The lectures are conducted in two different classes, namely class A as the Experimental Class and class B as the Control Class. From the calculation result after interpreted using Normalize Gain, there is an increase of higher learning result in student with interactive learning based on motion graphic, compared with student achievement on conventional learning. In this research, interactive multimedia learning based on motion graphic is effective toward the improvement of student learning in concept mastering indicator and on the aspect of making fashion design in digital format.

Mapping Soluble Guanylyl Cyclase and Protein Disulfide Isomerase Regions of Interaction.

Directory of Open Access Journals (Sweden)

Erin J Heckler

Full Text Available Soluble guanylyl cyclase (sGC is a heterodimeric nitric oxide (NO receptor that produces cyclic GMP. This signaling mechanism is a key component in the cardiovascular system. NO binds to heme in the β subunit and stimulates the catalytic conversion of GTP to cGMP several hundred fold. Several endogenous factors have been identified that modulate sGC function in vitro and in vivo. In previous work, we determined that protein disulfide isomerase (PDI interacts with sGC in a redox-dependent manner in vitro and that PDI inhibited NO-stimulated activity in cells. To our knowledge, this was the first report of a physical interaction between sGC and a thiol-redox protein. To characterize this interaction between sGC and PDI, we first identified peptide linkages between sGC and PDI, using a lysine cross-linking reagent and recently developed mass spectrometry analysis. Together with Flag-immunoprecipitation using sGC domain deletions, wild-type (WT and mutated PDI, regions of sGC involved in this interaction were identified. The observed data were further explored with computational modeling to gain insight into the interaction mechanism between sGC and oxidized PDI. Our results indicate that PDI interacts preferentially with the catalytic domain of sGC, thus providing a mechanism for PDI inhibition of sGC. A model in which PDI interacts with either the α or the β catalytic domain is proposed.

Understanding Mesoscale Land-Atmosphere Interactions in Arctic Region

Science.gov (United States)

Hong, X.; Wang, S.; Nachamkin, J. E.

2017-12-01

Land-atmosphere interactions in Arctic region are examined using the U.S. Navy Coupled Ocean/Atmosphere Mesoscale Prediction System (COAMPS©*) with the Noah Land Surface Model (LSM). Initial land surface variables in COAMPS are interpolated from the real-time NASA Land Information System (LIS). The model simulations are configured for three nest grids with 27-9-3 km horizontal resolutions. The simulation period is set for October 2015 with 12-h data assimilation update cycle and 24-h integration length. The results are compared with those simulated without using LSM and evaluated with observations from ONR Sea State R/V Sikuliaq cruise and the North Slope of Alaska (NSA). There are complex soil and vegetation types over the surface for simulation with LSM, compared to without LSM simulation. The results show substantial differences in surface heat fluxes between bulk surface scheme and LSM, which may have an important impact on the sea ice evolution over the Arctic region. Evaluations from station data show surface air temperature and relative humidity have smaller biases for simulation using LSM. Diurnal variation of land surface temperature, which is necessary for physical processes of land-atmosphere, is also better captured than without LSM.

The Design of Tools for Sketching Sensor-Based Interaction

DEFF Research Database (Denmark)

Brynskov, Martin; Lunding, Rasmus; Vestergaard, Lasse Steenbock

2012-01-01

, flexibility and cost, aimed at wearable and ultra-mobile prototyping where fast reaction is needed (e.g. in controlling sound), and we discuss the general issues facing this category of embodied interaction design tools. We then present the platform in more detail, both regarding hard- ware and software...

Russian HyperTutor: Designing Interactive Multimedia for the Macintosh.

Science.gov (United States)

Mitrevski, George

1995-01-01

Describes an interactive, multimedia computer program designed to teach Russian grammar, and accompany a commercial textbook. Each of the 35 lessons integrates graphics, sound, and animation. A dictionary and extensive vocabulary exercises are also included. Tutorials provide simple but concise grammar explanations that the teacher can edit or…

POPULATION MOBILITY CHARACTERISTIC: NOTES FROM THE URBAN-URBAN INTERACTION IN SEMARANG METROPOLITAN REGION

Directory of Open Access Journals (Sweden)

MARDHOTILLAH Santi

2016-12-01

Full Text Available The rapid growth of cities is characterized by the "pressure" in the form of increasingly dense urban areas, slums, traffic congestion, unemployment in the cities, and the number of illegal housing in the suburbs. This issue demonstrates the need for a balance between urban and rural areas. The balance is obtained through the interaction, and the interaction there is a process of "transfer" in the form of the human population, natural resources, and other supporting components. This view of the phenomenon makes many researchers conducting various studies in the context of the interaction between rural and urban. Furthermore, the study of the interaction of cities such as Salatiga and Semarang are in fact joined in the same region, KSN Kedungsepur. Semarang and surrounding developments as Semarang Metropolitan Region (SMR are the main attraction for the people who are around Semarang that caused an increase in the spatial interactions between Semarang and surrounding areas. From some areas belonging to KSN Kedungsepur, there are only two areas with the status of the city of Semarang city as a centre of KSN and Salatiga. This becomes interesting, unique conditions for studying the phenomenon under study is the interaction of the cities. The method used in this research was a quantitative method with descriptive analysis. Data was collected through a questionnaire survey technique primary by taking a random sample of migrants from Salatiga City and studied at the city of Semarang. The results of the study there were four mobility characteristics formed between Salatiga and Semarang, namely, commuting-boarding, boarding-commuting, boarding and boarding-permanent.

HyperCell: A Bio-inspired Design Framework for Real-time Interactive Architectures

Directory of Open Access Journals (Sweden)

Jia-Rey Chang

2018-01-01

Full Text Available This pioneering research focuses on Biomimetic Interactive Architecture using “Computation”, “Embodiment”, and “Biology” to generate an intimate embodied convergence to propose a novel rule-based design framework for creating organic architectures composed of swarm-based intelligent components. Furthermore, the research boldly claims that Interactive Architecture should emerge as the next truly Organic Architecture. As the world and society are dynamically changing, especially in this digital era, the research dares to challenge the Utilitas, Firmitas, and Venustas of the traditional architectural Weltanschauung, and rejects them by adopting the novel notion that architecture should be dynamic, fluid, and interactive. This project reflects a trajectory from the 1960’s with the advent of the avant-garde architectural design group, Archigram, and its numerous intriguing and pioneering visionary projects. Archigram’s non-standard, mobile, and interactive projects profoundly influenced a new generation of architects to explore the connection between technology and their architectural projects. This research continues this trend of exploring novel design thinking and the framework of Interactive Architecture by discovering the interrelationship amongst three major topics: “Computation”, “Embodiment”, and “Biology”. The project aims to elucidate pioneering research combining these three topics in one discourse: “Bio-inspired digital architectural design”. These three major topics will be introduced in this Summary.   “Computation”, is any type of calculation that includes both arithmetical and nonarithmetical steps and follows a well-defined model understood and described as, for example, an algorithm. But, in this research, refers to the use of data storage, parametric design application, and physical computing for developing informed architectural designs. “Form” has always been the most critical focus in

Decisive Constraints as a Creative Resource in Interaction Design

DEFF Research Database (Denmark)

Biskjaer, Michael Mose; Halskov, Kim

2014-01-01

‘decisive constraints’ based on a review of current, but dispersed, studies into creativity constraints. We build decisive constraints on two definitional conditions related to radical decision-making and creative turning points. To test our concept analytically and ensure its relevance to creative practice......, we apply the two definitional conditions to three media façade installation projects in which our interaction design research lab has been involved. In accord with insights from these case analyses, we argue that decisive constraints may inform current research into design processes and act......This article explores the observation that highly limiting, creative decisions of voluntary self-binding that radically prune the design solution space may in fact fuel and accelerate the process toward an innovative final design. To gain insight into this phenomenon, we propose the concept...

Interactive design for self-study and developing students’ critical thinking skills in electromagnetic radiation topic

Science.gov (United States)

Ambarwati, D.; Suyatna, A.

2018-01-01

The purpose of this research are to create interactive electronic school books (ESB) for electromagnetic radiation topic that can be used for self-study and increasing students’ critical thinking skills. The research method was based on the design of research and development (R&D) model of ADDIE. The research procedure is used limited the design of the product has been validated. Data source at interactive requirement analysis phase of ESB is student and high school teacher of class XII in Lampung province. The validation of interactive ESB designs is performed by experts in science education. The data of ESB interactive needs were collected using questionnaires and analyzed using quantitative descriptive. The results of the questionnaire obtained by 97% of books that are often used in the form of printed books from schools have not been interactive and foster critical thinking of students, and 55% of students stating physics books are used not meet expectations. Expectations of students in physics learning, teachers must use interactive electronic books. The results of the validation experts pointed out, the design of ESB produced is interactive, can be used for self-study, and increasing students’ critical thinking skills, which contains instruction manuals, learning objectives, learning materials, sample questions and discussion, video illustrations, animations, summaries, as well as interactive quizzes incorporating feedback exam practice and preparation for college entrance.

Gasdynamics of H II regions. V. The interaction of weak R ionization fronts with dense clouds

Energy Technology Data Exchange (ETDEWEB)

Tenorio-Tagle, G; Bedijn, P J

1981-06-01

The interaction of weak R-type ionization fronts with a density enhancement is calculated numerically as a function of time within the framework of the champagne model of the evolution of H II regions. Calculations are performed under the assumption of plane-parallel geometry for various relative densities of the cloud in which the exciting star is formed and a second cloud with which an ionization front from the first cloud interacts. The supersonic ionization front representing the outer boundary of an H II region experiencing the champagne phase is found to either evolve into a D-type front or remain of type R, depending on the absolute number of photons leaving the H II region that undergoes the champagne phase. Recombinations in the ionized gas eventually slow the ionization front, however photon fluxes allow it to speed up again, resulting in oscillatory propagation of the front. Front-cloud interactions are also shown to lead to the development of a backward-facing shock, a forward-facing shock, and a density maximum in the ionized gas. The results can be used to explain the origin of bright rims in H II regions.

Exploratory shaft facility preliminary designs - Gulf Interior Region salt domes

International Nuclear Information System (INIS)

1983-09-01

The purpose of the Preliminary Design Report, Gulf Interior Region, is to provide a description of the preliminary design for an Exploratory Shaft Facility on the Richton Dome, Mississippi. This issue of the report describes the preliminary design for constructing the exploratory shaft using the Large Hole Drilling method of construction and outlines the preliminary design and estimates of probable construction cost. The Preliminary Design Report is prepared to complement and summarize other documents that comprise the design at the preliminary stage of completion, December 1982. Other design documents include drawings, cost estimates and schedules. The preliminary design drawing package, which includes the construction schedule drawing, depicts the descriptions in this report. For reference, a list of the drawing titles and corresponding numbers are included in the Appendix. The report is divided into three principal sections: Design Basis, Facility Description and Construction Cost Estimate

Salt-bridge networks within globular and disordered proteins: characterizing trends for designable interactions.

Science.gov (United States)

Basu, Sankar; Mukharjee, Debasish

2017-07-01

There has been considerable debate about the contribution of salt bridges to the stabilization of protein folds, in spite of their participation in crucial protein functions. Salt bridges appear to contribute to the activity-stability trade-off within proteins by bringing high-entropy charged amino acids into close contacts during the course of their functions. The current study analyzes the modes of association of salt bridges (in terms of networks) within globular proteins and at protein-protein interfaces. While the most common and trivial type of salt bridge is the isolated salt bridge, bifurcated salt bridge appears to be a distinct salt-bridge motif having a special topology and geometry. Bifurcated salt bridges are found ubiquitously in proteins and interprotein complexes. Interesting and attractive examples presenting different modes of interaction are highlighted. Bifurcated salt bridges appear to function as molecular clips that are used to stitch together large surface contours at interacting protein interfaces. The present work also emphasizes the key role of salt-bridge-mediated interactions in the partial folding of proteins containing long stretches of disordered regions. Salt-bridge-mediated interactions seem to be pivotal to the promotion of "disorder-to-order" transitions in small disordered protein fragments and their stabilization upon binding. The results obtained in this work should help to guide efforts to elucidate the modus operandi of these partially disordered proteins, and to conceptualize how these proteins manage to maintain the required amount of disorder even in their bound forms. This work could also potentially facilitate explorations of geometrically specific designable salt bridges through the characterization of composite salt-bridge networks. Graphical abstract ᅟ.

Cognitive engineering models: A prerequisite to the design of human-computer interaction in complex dynamic systems

Science.gov (United States)

Mitchell, Christine M.

1993-01-01

This chapter examines a class of human-computer interaction applications, specifically the design of human-computer interaction for the operators of complex systems. Such systems include space systems (e.g., manned systems such as the Shuttle or space station, and unmanned systems such as NASA scientific satellites), aviation systems (e.g., the flight deck of 'glass cockpit' airplanes or air traffic control) and industrial systems (e.g., power plants, telephone networks, and sophisticated, e.g., 'lights out,' manufacturing facilities). The main body of human-computer interaction (HCI) research complements but does not directly address the primary issues involved in human-computer interaction design for operators of complex systems. Interfaces to complex systems are somewhat special. The 'user' in such systems - i.e., the human operator responsible for safe and effective system operation - is highly skilled, someone who in human-machine systems engineering is sometimes characterized as 'well trained, well motivated'. The 'job' or task context is paramount and, thus, human-computer interaction is subordinate to human job interaction. The design of human interaction with complex systems, i.e., the design of human job interaction, is sometimes called cognitive engineering.

Interacting with Compatriots in Russian Regions: the Experience of Tatarstan

Directory of Open Access Journals (Sweden)

Radik R. Gimatdinov

2015-01-01

Full Text Available Work with compatriots promoting the cultural presence of Russia in the world becomes an important element of "soft power" Supporting the preservation and development among compatriots the cultural traditions of the Tatar people as components of ethnic and cultural diversity of Russia, Tatarstan participates in the implementation of the national foreign policy. The Republic of Tatarstan interacts constructively with the Russian Foreign Ministry, Rossotrudnichestvo, takes part in the activities of the Government Commission on Compatriots Abroad. Work with compatriots is carried out by the executive authorities of the republic within a number of regional government programs. The Coordination Council for the Affairs of Compatriots is created in Tatarstan .The sessions of the World Congress of Tatars (WCT are held every five years. The Executive Committee of the WCT is in contact with one and a half hundreds of Tatar organizations in about 40 countries. The most important event in the in the cultural life of Tatar diaspora is celebration of Sabantui. The Days of the Republic of Tatarstan are also held abroad with great success,and they are aimed at strengthening bilateral cooperation together with the promotion of Tatar culture in the world.A special place in the activities of all the Tatar communities takes the honoring and support of the WWII and labor veterans. Work with the young people is the part of interaction with compatriots: youth forums and camps with the study of the Tatar language are organized. Attracting of compatriots to Tatarstan universities is carried out within Russian government programs.The work of strengthening business ties in the framework of the Tatar diaspora is conducted systematically. The interaction with various target groups of compatriots (women, scientists, cultural figures is organized.The authors propose measures of uniting overseas communities of compatriots and exploiting their potential to promote the interests

Particle acceleration at corotating interaction regions in the three-dimensional heliosphere

International Nuclear Information System (INIS)

Desai, M.I.; Marsden, R.G.; Sanderson, T.R.; Balogh, A.; Forsyth, R.J.; Gosling, J.T.

1998-01-01

We have investigated the relationship between the energetic (∼1MeV) proton intensity (J) and the magnetic compression ratio (C) measured at the trailing edges of corotating interaction regions observed at Ulysses. In general, our results show that the proton intensity was well correlated with the compression ratio, provided that the seed intensity remained constant, consistent with predictions of the Fermi model. Specifically, our results indicate that particles were accelerated to above ∼1MeV in energy at or near the trailing edges of the compression regions observed in the midlatitude southern heliosphere, irrespective of whether the bounding reverse shocks were present or not. On the basis of this, we conclude that shock acceleration is probably not the only mechanism by which particles are accelerated to above ∼1MeV in energy at compression or interaction regions (CIRs). On the basis of magnetic field measurements obtained near the trailing edges of several midlatitude CIRs, we propose that particles could have been accelerated via the Fermi mechanism by being scattered back and forth across the trailing edges of the compression regions by large-amplitude Alfvacute en waves. Our results also show that the proton intensity was well correlated with the compression ratio during low solar activity periods but was essentially independent of C during periods of high solar activity. We suggest that the correlation between J and C was not observed during solar active periods because of significant variations in the seed intensity that result from sporadic contributions from transient solar events. In contrast, the correlation was observable during quiescent periods probably because contributions from transients had decreased dramatically, which allowed the CIRs to accelerate particles out of a seed population whose intensity remained relatively unperturbed. copyright 1998 American Geophysical Union

NMR characterisation of the minimal interacting regions of centrosomal proteins 4.1R and NuMA1: effect of phosphorylation

Directory of Open Access Journals (Sweden)

Bruix Marta

2010-01-01

Full Text Available Abstract Background Some functions of 4.1R in non-erythroid cells are directly related with its distinct sub-cellular localisation during cell cycle phases. During mitosis, 4.1R is implicated in cell cycle progression and spindle pole formation, and co-localizes with NuMA1. However, during interphase 4.1R is located in the nucleus and only partially co-localizes with NuMA1. Results We have characterized by NMR the structural features of the C-terminal domain of 4.1R and those of the minimal region (the last 64 residues involved in the interaction with NuMA1. This subdomain behaves as an intrinsically unfolded protein containing a central region with helical tendency. The specific residues implicated in the interaction with NuMA1 have been mapped by NMR titrations and involve the N-terminal and central helical regions. The segment of NuMA1 that interacts with 4.1R is phosphorylated during mitosis. Interestingly, NMR data indicates that the phosphorylation of NuMA1 interacting peptide provokes a change in the interaction mechanism. In this case, the recognition occurs through the central helical region as well as through the C-terminal region of the subdomain meanwhile the N-terminal region do not interact. Conclusions These changes in the interaction derived from the phosphorylation state of NuMA1 suggest that phosphorylation can act as subtle mechanism of temporal and spatial regulation of the complex 4.1R-NuMA1 and therefore of the processes where both proteins play a role.

Teachers’ Pedagogic Design of Digital Interactive Whiteboard Materials in the UK Secondary School

Directory of Open Access Journals (Sweden)

Carey Jewitt

2008-03-01

Full Text Available Teachers have always made texts for use in the classroom. The wide spread introduction of Interactive whiteboard (IWB technology into UK classrooms, and the screen more generally, makes the multimodal resources of color, image, dynamic movement, and sound newly available for pedagogic design in newly connectable ways. These facilities present teachers with new questions about how to design and use teaching materials, new possibilites and constraints. This presentation will examine teachers' design of digital multimodal resources for IWBs and the influence of prevalent policy discourses of interactivity, multimodality and fast pace influence on teacher’s digital materials for the IWB.

Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors.

Science.gov (United States)

Suebsuwong, Chalada; Pinkas, Daniel M; Ray, Soumya S; Bufton, Joshua C; Dai, Bing; Bullock, Alex N; Degterev, Alexei; Cuny, Gregory D

2018-02-15

Development of selective kinase inhibitors remains a challenge due to considerable amino acid sequence similarity among family members particularly in the ATP binding site. Targeting the activation loop might offer improved inhibitor selectivity since this region of kinases is less conserved. However, the strategy presents difficulties due to activation loop flexibility. Herein, we report the design of receptor-interacting protein kinase 2 (RIPK2) inhibitors based on pan-kinase inhibitor regorafenib that aim to engage basic activation loop residues Lys169 or Arg171. We report development of CSR35 that displayed >10-fold selective inhibition of RIPK2 versus VEGFR2, the target of regorafenib. A co-crystal structure of CSR35 with RIPK2 revealed a resolved activation loop with an ionic interaction between the carboxylic acid installed in the inhibitor and the side-chain of Lys169. Our data provides principle feasibility of developing activation loop targeting type II inhibitors as a complementary strategy for achieving improved selectivity. Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Design of an interactive digital nutritional education package for elderly people.

Science.gov (United States)

Ali, Nazlena Mohamad; Shahar, Suzana; Kee, You Lee; Norizan, Azir Rezha; Noah, Shahrul Azman Mohd

2012-12-01

Designing a system for the elderly is crucial, as aging is associated with physiological changes that may impair perception, cognition and other social aspects; therefore, many aspects need consideration, especially in interface design. This study was conducted to develop a digital nutritional education package (WE Sihat) by following appropriate guidelines for elderly people to achieve better design interface and interaction. Touch-screen technology was used as a platform for user interaction. The nutritional content was based on previous nutrition studies and a lifestyle education package on healthy aging, which contains four modules. The questionnaires were distributed to 31 Malay subjects aged 60-76 years old, containing an evaluation about the overall content, graphics, design layout, colour, font size, audio/video, user-perceived satisfaction and acceptance levels. The findings showed positive feedback and acceptance. Most subjects agreed that the digital nutritional education package can increase their nutritional knowledge for a healthy lifestyle and is easy to use. The touch-screen technology was also well accepted by elderly people and can be used as a kiosk for disseminating nutrition education for healthy aging.

Designing Playful Interactive Installations for Urban Environments - The SwingScape Experience

DEFF Research Database (Denmark)

Grønbæk, Kaj; Kortbek, Karen Johanne; Christensen, Claus Møller

2012-01-01

. The design issues include: creating playful and collective interaction, making a familiar swing interaction simulate the experience of a music mixing board, providing gentle integration of multimedia (light and sound) in the atmosphere of an urban space, and finally making installations robust and safe...... at an urban playground. The objectives of SwingScape are to encourage physical activity as well as creating a playful and social experience in an urban space. The interaction techniques include movement sensors built into swings, LED lights, and an ambient loudspeaker system covering approx. 180 square meters...

Cultural ergonomics in interactional and experiential design: conceptual framework and case study of the Taiwanese twin cup.

Science.gov (United States)

Lin, Chih-Long; Chen, Si-Jing; Hsiao, Wen-Hsin; Lin, Rungtai

2016-01-01

Cultural ergonomics is an approach that considers interaction- and experience-based variations among cultures. Designers need to develop a better understanding of cultural ergonomics not just to participate in cultural contexts but also to develop interactive experiences for users. Cultural ergonomics extends our understanding of cultural meaning and our ability to utilize such understanding for design and evaluate everyday products. This study aims to combine cultural ergonomics and interactive design to explore human-culture interaction in user experiences. The linnak is a typical Taiwanese aboriginal cultural object. This study examined the cultural meaning and operational interface of the linnak, as well as the scenarios in which it is used in interaction and user experiences. The results produced a cultural ergonomics interface for examining the manner in which designers communicate across cultures as well as the interweaving of design and culture in the design process. Copyright © 2015 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Two-Level Designs to Estimate All Main Effects and Two-Factor Interactions

NARCIS (Netherlands)

Eendebak, P.T.; Schoen, E.D.

2017-01-01

We study the design of two-level experiments with N runs and n factors large enough to estimate the interaction model, which contains all the main effects and all the two-factor interactions. Yet, an effect hierarchy assumption suggests that main effect estimation should be given more prominence

Proposal of a Technical Design of the ATLAS Forward Region Shielding

CERN Document Server

Leroy, C; Palla, J; Pospísil, S; Puchmajer, P; Sodomka, J; Stekl, I

2002-01-01

The aim of this note is to present a technical design of the ATLAS forward region. The concept is based on segmented shielding supported by the results of an experiment performed at CERN - PS and Monte Carlo simulations extending these results to ATLAS situation. This concept is translated into a practical engineering design.

Enculturating science: Community-centric design of behavior change interactions for accelerating health impact.

Science.gov (United States)

Kumar, Vishwajeet; Kumar, Aarti; Ghosh, Amit Kumar; Samphel, Rigzin; Yadav, Ranjanaa; Yeung, Diana; Darmstadt, Gary L

2015-08-01

Despite significant advancements in the scientific evidence base of interventions to improve newborn survival, we have not yet been able to "bend the curve" to markedly accelerate global rates of reduction in newborn mortality. The ever-widening gap between discovery of scientific best practices and their mass adoption by families (the evidence-practice gap) is not just a matter of improving the coverage of health worker-community interactions. The design of the interactions themselves must be guided by sound behavioral science approaches such that they lead to mass adoption and impact at a large scale. The main barrier to the application of scientific approaches to behavior change is our inability to "unbox" the "black box" of family health behaviors in community settings. The authors argue that these are not black boxes, but in fact thoughtfully designed community systems that have been designed and upheld, and have evolved over many years keeping in mind a certain worldview and a common social purpose. An empathetic understanding of these community systems allows us to deconstruct the causal pathways of existing behaviors, and re-engineer them to achieve desired outcomes. One of the key reasons for the failure of interactions to translate into behavior change is our failure to recognize that the content, context, and process of interactions need to be designed keeping in mind an organized community system with a very different worldview and beliefs. In order to improve the adoption of scientific best practices by communities, we need to adapt them to their culture by leveraging existing beliefs, practices, people, context, and skills. The authors present a systems approach for community-centric design of interactions, highlighting key principles for achieving intrinsically motivated, sustained change in social norms and family health behaviors, elucidated with progressive theories from systems thinking, management sciences, cross-cultural psychology, learning

Applying systemic-structural activity theory to design of human-computer interaction systems

CERN Document Server

Bedny, Gregory Z; Bedny, Inna

2015-01-01

Human-Computer Interaction (HCI) is an interdisciplinary field that has gained recognition as an important field in ergonomics. HCI draws on ideas and theoretical concepts from computer science, psychology, industrial design, and other fields. Human-Computer Interaction is no longer limited to trained software users. Today people interact with various devices such as mobile phones, tablets, and laptops. How can you make such interaction user friendly, even when user proficiency levels vary? This book explores methods for assessing the psychological complexity of computer-based tasks. It also p

A new approach in the design of an interactive environment for teaching Hamiltonian digraphs

International Nuclear Information System (INIS)

Iordan, A E; Panoiu, M

2014-01-01

In this article the authors present the necessary steps in object orientated design of an interactive environment that is dedicated to the process of acquaintances assimilation in Hamiltonian graphs theory domain, especially for the simulation of algorithms which determine the Hamiltonian trails and circuits. The modelling of the interactive environment is achieved through specific UML diagrams representing the steps of analysis, design and implementation. This interactive environment is very useful for both students and professors, because computer programming domain, especially digraphs theory domain is comprehended and assimilated with difficulty by students

A Human Work Interaction Design (HWID) Case Study in E-Government and Public Information Systems

DEFF Research Database (Denmark)

Clemmensen, Torkil

2011-01-01

This paper first outlines a revised version of the general HWID framework, with a focus on what connects empirical work analysis and interaction design, and then presents a case study of the Danish government one-for-all authentication system NemID. The case is briefly analyzed, using ethnomethod...... in studying how human work analysis and interaction design in concrete cases are related and connected.......This paper first outlines a revised version of the general HWID framework, with a focus on what connects empirical work analysis and interaction design, and then presents a case study of the Danish government one-for-all authentication system NemID. The case is briefly analyzed, using...... ethnomethodology, work domain/task analysis, and the HWID approach, and comparing the results. Compared to the traditional approaches, the HWID focus on case-specific connections between human work and interaction design, gives different and supplementary answers. The conclusion is that there are benefits...

An exploration in kitchen blender interactions aimed at designing for high levels of engagement

NARCIS (Netherlands)

van Rheden, V.; Hengeveld, B.J.

2015-01-01

This paper illustrates three novel kitchen blender interactions aimed at bringing about a higher level of engagement with interactive products, as a response to current, seemingly un-engaging interactions. We describe our starting points and approach after which we present the designed blender

CADRIGS--computer aided design reliability interactive graphics system

International Nuclear Information System (INIS)

Kwik, R.J.; Polizzi, L.M.; Sticco, S.; Gerrard, P.B.; Yeater, M.L.; Hockenbury, R.W.; Phillips, M.A.

1982-01-01

An integrated reliability analysis program combining graphic representation of fault trees, automated data base loadings and reference, and automated construction of reliability code input files was developed. The functional specifications for CADRIGS, the computer aided design reliability interactive graphics system, are presented. Previously developed fault tree segments used in auxiliary feedwater system safety analysis were constructed on CADRIGS and, when combined, yielded results identical to those resulting from manual input to the same reliability codes

Improving the radiologist–CAD interaction: designing for appropriate trust

International Nuclear Information System (INIS)

Jorritsma, W.; Cnossen, F.; Ooijen, P.M.A. van

2015-01-01

Computer-aided diagnosis (CAD) has great potential to improve radiologists' diagnostic performance. However, the reported performance of the radiologist–CAD team is lower than what might be expected based on the performance of the radiologist and the CAD system in isolation. This indicates that the interaction between radiologists and the CAD system is not optimal. An important factor in the interaction between humans and automated aids (such as CAD) is trust. Suboptimal performance of the human–automation team is often caused by an inappropriate level of trust in the automation. In this review, we examine the role of trust in the radiologist–CAD interaction and suggest ways to improve the output of the CAD system so that it allows radiologists to calibrate their trust in the CAD system more effectively. Observer studies of the CAD systems show that radiologists often have an inappropriate level of trust in the CAD system. They sometimes under-trust CAD, thereby reducing its potential benefits, and sometimes over-trust it, leading to diagnostic errors they would not have made without CAD. Based on the literature on trust in human–automation interaction and the results of CAD observer studies, we have identified four ways to improve the output of CAD so that it allows radiologists to form a more appropriate level of trust in CAD. Designing CAD systems for appropriate trust is important and can improve the performance of the radiologist–CAD team. Future CAD research and development should acknowledge the importance of the radiologist–CAD interaction, and specifically the role of trust therein, in order to create the perfect artificial partner for the radiologist. This review focuses on the role of trust in the radiologist–CAD interaction. The aim of the review is to encourage CAD developers to design for appropriate trust and thereby improve the performance of the radiologist–CAD team. - Highlights: • Radiologists often have an inappropriate

Designing Interactive Storytelling: A Virtual Environment for Personal Experience Narratives

OpenAIRE

Ladeira , Ilda; Marsden , Gary; Green , Lesley

2011-01-01

Part 1: Long and Short Papers; International audience; We describe an ongoing collaboration with the District Six Museum, in Cape Town, aimed at designing a storytelling prototype for preserving personal experience narratives. We detail the design of an interactive virtual environment (VE) which was inspired by a three month ethnography of real-life oral storytelling. The VE places the user as an audience member in a virtual group listening to two storytelling agents capable of two forms of i...

Study of neutron-proton interaction in the 300-700 MeV energy region

International Nuclear Information System (INIS)

Northcliffe, L.C.

1989-08-01

The primary objective of the program is investigation of the nucleon-nucleon (NN) interaction, in the medium-energy region, in both elastic and inelastic channels. Most of the results of this research have already been published in refereed journals and will not be discussed here

Optimal design method to minimize users' thinking mapping load in human-machine interactions.

Science.gov (United States)

Huang, Yanqun; Li, Xu; Zhang, Jie

2015-01-01

The discrepancy between human cognition and machine requirements/behaviors usually results in serious mental thinking mapping loads or even disasters in product operating. It is important to help people avoid human-machine interaction confusions and difficulties in today's mental work mastered society. Improving the usability of a product and minimizing user's thinking mapping and interpreting load in human-machine interactions. An optimal human-machine interface design method is introduced, which is based on the purpose of minimizing the mental load in thinking mapping process between users' intentions and affordance of product interface states. By analyzing the users' thinking mapping problem, an operating action model is constructed. According to human natural instincts and acquired knowledge, an expected ideal design with minimized thinking loads is uniquely determined at first. Then, creative alternatives, in terms of the way human obtains operational information, are provided as digital interface states datasets. In the last, using the cluster analysis method, an optimum solution is picked out from alternatives, by calculating the distances between two datasets. Considering multiple factors to minimize users' thinking mapping loads, a solution nearest to the ideal value is found in the human-car interaction design case. The clustering results show its effectiveness in finding an optimum solution to the mental load minimizing problems in human-machine interaction design.

Experimental investigation on feasibility of two-region-designed pebble-bed high-temperature gas-cooled reactor

International Nuclear Information System (INIS)

Yang Xingtuan; Hu Wenping; Jiang Shengyao

2009-01-01

Phenomenological experiments were performed on a 2-dimensional scaled model of the two-region designed pebble-bed high-temperature gas-cooled reactor core consisting of the distinct fuel pebble region and graphite pebble region. Issues with respect to the feasibility of the two-region design, including the establishment of the two-region arrangement, the mixing zone between the two regions, and the stagnant zone existence, were investigated. Three equilibrium conditions were proposed to evaluate the stable two-region arrangement formation. The general characteristics of the flow of the pebble bed were analyzed on basis of the observed phenomenon. It was found that a stable two-region arrangement was formed under the experimental conditions: the pebbles' motion was to some extent random but also confined by the neighbors of pebbles so that the mixing zone is constrained to a reasonable size. Guide plates utilized to improve mixing are proved to be effective without noticeable effect on the two-region arrangement features. Stagnant zones were observed under the experimental conditions and they were expected to be avoided by improving the design of the experimental setup. (author)

ON MAGNETIC ACTIVITY BAND OVERLAP, INTERACTION, AND THE FORMATION OF COMPLEX SOLAR ACTIVE REGIONS

Energy Technology Data Exchange (ETDEWEB)

McIntosh, Scott W. [High Altitude Observatory, National Center for Atmospheric Research, P.O. Box 3000, Boulder, CO 80307 (United States); Leamon, Robert J., E-mail: mscott@hao.ucar.edu [Department of Physics, Montana State University, Bozeman, MT 59717 (United States)

2014-11-20

Recent work has revealed a phenomenological picture of the how the ∼11 yr sunspot cycle of the Sun arises. The production and destruction of sunspots is a consequence of the latitudinal-temporal overlap and interaction of the toroidal magnetic flux systems that belong to the 22 yr magnetic activity cycle and are rooted deep in the Sun's convective interior. We present a conceptually simple extension of this work, presenting a hypothesis on how complex active regions can form as a direct consequence of the intra- and extra-hemispheric interaction taking place in the solar interior. Furthermore, during specific portions of the sunspot cycle, we anticipate that those complex active regions may be particularly susceptible to profoundly catastrophic breakdown, producing flares and coronal mass ejections of the most severe magnitude.

Interactions of early adversity with stress-related gene polymorphisms impact regional brain structure in females.

Science.gov (United States)

Gupta, Arpana; Labus, Jennifer; Kilpatrick, Lisa A; Bonyadi, Mariam; Ashe-McNalley, Cody; Heendeniya, Nuwanthi; Bradesi, Sylvie; Chang, Lin; Mayer, Emeran A

2016-04-01

Early adverse life events (EALs) have been associated with regional thinning of the subgenual cingulate cortex (sgACC), a brain region implicated in the development of disorders of mood and affect, and often comorbid functional pain disorders, such as irritable bowel syndrome (IBS). Regional neuroinflammation related to chronic stress system activation has been suggested as a possible mechanism underlying these neuroplastic changes. However, the interaction of genetic and environmental factors in these changes is poorly understood. The current study aimed to evaluate the interactions of EALs and candidate gene polymorphisms in influencing thickness of the sgACC. 210 female subjects (137 healthy controls; 73 IBS) were genotyped for stress and inflammation-related gene polymorphisms. Genetic variation with EALs, and diagnosis on sgACC thickness was examined, while controlling for race, age, and total brain volume. Compared to HCs, IBS had significantly reduced sgACC thickness (p = 0.03). Regardless of disease group (IBS vs. HC), thinning of the left sgACC was associated with a significant gene-gene environment interaction between the IL-1β genotype, the NR3C1 haplotype, and a history of EALs (p = 0.05). Reduced sgACC thickness in women with the minor IL-1β allele, was associated with EAL total scores regardless of NR3C1 haplotype status (p = 0.02). In subjects homozygous for the major IL-1β allele, reduced sgACC with increasing levels of EALs was seen only with the less common NR3C1 haplotype (p = 0.02). These findings support an interaction between polymorphisms related to stress and inflammation and early adverse life events in modulating a key region of the emotion arousal circuit.

Lateral and medial ventral occipitotemporal regions interact during the recognition of images revealed from noise

Directory of Open Access Journals (Sweden)

Barbara eNordhjem

2016-01-01

Full Text Available Several studies suggest different functional roles for the medial and the lateral ventral sections in object recognition. Texture and surface information is processed in medial regions, while shape information is processed in lateral sections. This begs the question whether and how these functionally specialized sections interact with each other and with early visual cortex to facilitate object recognition. In the current research, we set out to answer this question. In an fMRI study, thirteen subjects viewed and recognized images of objects and animals that were gradually revealed from noise while their brains were being scanned. We applied dynamic causal modeling (DCM – a method to characterize network interactions – to determine the modulatory effect of object recognition on a network comprising the primary visual cortex (V1, the lingual gyrus (LG in medial ventral cortex and the lateral occipital cortex (LO. We found that object recognition modulated the bilateral connectivity between LG and LO. Moreover, the feed-forward connectivity from V1 to LG and LO was modulated, while there was no evidence for feedback from these regions to V1 during object recognition. In particular, the interaction between medial and lateral areas supports a framework in which visual recognition of objects is achieved by networked regions that integrate information on image statistics, scene content and shape – rather than by a single categorically specialized region – within the ventral visual cortex.

A tabletop interactive storytelling system: designing for social interaction

NARCIS (Netherlands)

Alofs, Thijs; Theune, Mariet; Swartjes, I.M.T.

This paper presents the Interactive Storyteller, a multi-user interface for AI-based interactive storytelling, where stories emerge from the interaction of human players with intelligent characters in a simulated story world. To support face-to-face contact and social interaction, we position users

A brief comparison of existing regional green building design standards in China

Science.gov (United States)

Wang, J.; Liu, Y.; Ren, J.; Cho, S.

2017-03-01

A large country with a variety of regional natural, cultural and economic conditions, China has established a number of green building design (GBD) standards both at national and regional (provincial and municipal) levels. Some researches have been conducted to review and compare such standards. The main aim was to provide valuable references for the establishment of new regionally specific GBD standards in different regions of the country. This paper introduces the preliminary results of the researches. The distribution, frameworks and content of the existing regional GBD standards are introduced and compared in relating to the regionally specific climate, resource, economic and cultural conditions. Conclusions are provided and further researches are recommended.

A Novel Design for Drug-Drug Interaction Alerts Improves Prescribing Efficiency.

Science.gov (United States)

Russ, Alissa L; Chen, Siying; Melton, Brittany L; Johnson, Elizabette G; Spina, Jeffrey R; Weiner, Michael; Zillich, Alan J

2015-09-01

Drug-drug interactions (DDIs) are common in clinical care and pose serious risks for patients. Electronic health records display DDI alerts that can influence prescribers, but the interface design of DDI alerts has largely been unstudied. In this study, the objective was to apply human factors engineering principles to alert design. It was hypothesized that redesigned DDI alerts would significantly improve prescribers' efficiency and reduce prescribing errors. In a counterbalanced, crossover study with prescribers, two DDI alert designs were evaluated. Department of Veterans Affairs (VA) prescribers were video recorded as they completed fictitious patient scenarios, which included DDI alerts of varying severity. Efficiency was measured from time-stamped recordings. Prescribing errors were evaluated against predefined criteria. Efficiency and prescribing errors were analyzed with the Wilcoxon signed-rank test. Other usability data were collected on the adequacy of alert content, prescribers' use of the DDI monograph, and alert navigation. Twenty prescribers completed patient scenarios for both designs. Prescribers resolved redesigned alerts in about half the time (redesign: 52 seconds versus original design: 97 seconds; p<.001). Prescribing errors were not significantly different between the two designs. Usability results indicate that DDI alerts might be enhanced by facilitating easier access to laboratory data and dosing information and by allowing prescribers to cancel either interacting medication directly from the alert. Results also suggest that neither design provided adequate information for decision making via the primary interface. Applying human factors principles to DDI alerts improved overall efficiency. Aspects of DDI alert design that could be further enhanced prior to implementation were also identified.

An Agenda for Designing Natural Interaction in a Museum Context

DEFF Research Database (Denmark)

Lund, Morten

2012-01-01

to the design of digitally based interaction. The digital nature of these technologies enables convergense and new combinations of existing objects and contexts, but also the establishment of new objects and contexts. This potential of digital technologies is very well illustrated by the Multiverse model...

Designing Interactive Multimedia Instruction To Enable and Enhance Information Literacy.

Science.gov (United States)

Amidon, Leslie E.

2001-01-01

Addresses key strategies for the design and development of Interactive Multimedia Instruction (IMI) programs for adult learners, focusing on the removal of learning barriers and the incorporation of information literacy principles. Barriers include financial constraints, socio-economic and social class, communication skills, time constraints,…

Brush and learn : transforming tooth brushing behavior through interactive materiality, a design exploration

NARCIS (Netherlands)

Bruns, M.; Stienstra, J.T.; Dijkstra, R.

2014-01-01

To counteract the increased tendency in skill learning addressing our cognitive abilities we discuss an opportunity on how performance skills can be trained by means of inherent feed forward through interactive materiality. We address this approach in the context of designing an interactive

User-Centered Design and Interactive Health Technologies for Patients

Science.gov (United States)

De Vito Dabbs, Annette; Myers, Brad A.; Mc Curry, Kenneth R.; Dunbar-Jacob, Jacqueline; Hawkins, Robert P.; Begey, Alex; Dew, Mary Amanda

2010-01-01

Despite recommendations that patients be involved in the design and testing of health technologies, few reports describe how to involve patients in systematic and meaningful ways to ensure that applications are customized to meet their needs. User-centered design (UCD) is an approach that involves end-users throughout the development process so that technology support tasks, are easy to operate, and are of value to users. In this paper we provide an overview of UCD and use the development of Pocket Personal Assistant for Tracking Health (Pocket PATH), to illustrate how these principles and techniques were applied to involve patients in the development of this interactive health technology. Involving patient-users in the design and testing ensured functionality and usability, therefore increasing the likelihood of promoting the intended health outcomes. PMID:19411947

Investigating Near Space Interaction Regions: Developing a Remote Observatory

Science.gov (United States)

Gallant, M.; Mierkiewicz, E. J.; Oliversen, R. J.; Jaehnig, K.; Percival, J.; Harlander, J.; Englert, C. R.; Kallio, R.; Roesler, F. L.; Nossal, S. M.; Gardner, D.; Rosborough, S.

2016-12-01

The Investigating Near Space Interaction Regions (INSpIRe) effort will (1) establish an adaptable research station capable of contributing to terrestrial and planetary aeronomy; (2) integrate two state-of-the-art second generation Fabry-Perot (FP) and Spatial Heteorodyne Spectrometers (SHS) into a remotely operable configuration; (3) deploy this instrumentation to a clear-air site, establishing a stable, well-calibrated observatory; (4) embark on a series of observations designed to contribute to three major areas of geocoronal research: geocoronal physics, structure/coupling, and variability. This poster describes the development of the INSpIRe remote observatory. Based at Embry-Riddle Aeronautical University (ERAU), initiative INSpIRe provides a platform to encourage the next generation of researchers to apply knowledge gained in the classroom to real-world science and engineering. Students at ERAU contribute to the INSpIRe effort's hardware and software needs. Mechanical/optical systems are in design to bring light to any of four instruments. Control software is in development to allow remote users to control everything from dome and optical system operations to calibration and data collection. In April 2016, we also installed and tested our first science instrument in the INSpIRe trailer, the Redline DASH Demonstration Instrument (REDDI). REDDI uses Doppler Asymmetric Spatial Heterodyne (DASH) spectroscopy, and its deployment as part of INSpIRe is a collaborative research effort between the Naval Research Lab, St Cloud State University, and ERAU. Similar to a stepped Michelson device, REDDI measures oxygen (630.0 nm) winds from the thermosphere. REDDI is currently mounted in a temporary location under INSpIRe's main siderostat until its entrance optical system can be modified. First light tests produced good signal-to-noise fringes in ten minute integrations, indicating that we will soon be able to measure thermospheric winds from our Daytona Beach testing site

The System-Supplementing Effect of the Interaction between Innovative Capacity and Institutional Environment Factors of a Region

Directory of Open Access Journals (Sweden)

Viktor Nikolayevich Ovchinnikov

2016-06-01

Full Text Available In the article, the effect of interaction between the development level of regional innovative capacity and its innovative and institutional infrastructure is traced. The research objective is to prove the hypothesis of the essential impact of the regional institutional and information environment on its innovative capacity, the identification of the effect of their systemsupplementing interaction. From the standpoint of the methodology of system-structural research its components are allocated within the innovative capacity of the regional innovative system (RIS, they are presented by a corporate sector, the structures of small and medium business, and also by the subjects of ethnic economy. The use of essential-analytical and functional approaches has revealed the leading role of intangible assets of the corporate sector of the economy in region’s innovative development. The correlation and regression analysis has confirmed the essential dependence of the innovative activity of the region on the systemic completeness of the development of its institutional and infrastructure environment. The results of the research have shown that to ensure the system-supplementing effect of the interaction between innovative capacity and the factors of its activation in the sphere of institutional infrastructure, it is necessary to consistently develop its operational base — the institutions of RIS. The recommendations reasoned in the article may be used for the development of regional innovation strategies, the formation of innovation clusters. The three-component structure of the innovation cluster of the region is offered; its integrating function in relation to the innovative components of the regional sectoral clusters is determined. The factors constraining the growth of innovation activity of the regional economic subjects are revealed and the recommendations on the development of the institutional and infrastructural environment of the Rostov

77 FR 9946 - Draft Guidance for Industry on Drug Interaction Studies-Study Design, Data Analysis, Implications...

Science.gov (United States)

2012-02-21

... industry entitled ``Drug Interaction Studies--Study Design, Data Analysis, Implications for Dosing, and... data analysis in the context of identifying potential drug interactions. The guidance also addresses... Studies--Study Design, Data Analysis, and Implications for Dosing and Labeling.'' Comments were received...

Emotional Engagement, Social Interactions, and the Development of an Afterschool Game Design Curriculum

Science.gov (United States)

Kwah, Helen; Milne, Catherine; Tsai, Tzuchi; Goldman, Ricki; Plass, Jan L.

2016-01-01

This formative design study examines how a program curriculum and implementation was emergently (re)designed in dynamic relation to the expressed emotions of teachers and students. The context was a yearlong afterschool game design program for STEM learning at an urban and public all-girls middle school. Using Randall Collins' (Interaction ritual…

Investigating the role of aesthetics for interaction design

DEFF Research Database (Denmark)

Stavrakos, Stavros-Konstantinos; Ahmed-Kristensen, Saeema

2013-01-01

Two important aspects when designing products is to focus on comfort and to define the aesthetic and emotional value of the product. The main purpose of this research is to answer the question of how attractiveness perceived through the sensory inputs affects the assessment of comfort as well...... when the levels of attractiveness increase and vice versa. The findings further indicate that there are strong, significant correlations between scores of comfort and product adjectives commonly used to describe product attributes such as size, weight and surface material. Hence, there is an emotional...... dimension of comfort which is initiated by the visual input during a human – product interaction and is affected by the attractiveness towards the product. In their endeavor to develop successful and comfortable products designers should focus more on attractiveness....

Wind tunnel study of the wind turbine interaction with a boundary-layer flow: Upwind region, turbine performance, and wake region

Science.gov (United States)

Bastankhah, M.; Porté-Agel, F.

2017-06-01

Comprehensive wind tunnel experiments were carried out to study the interaction of a turbulent boundary layer with a wind turbine operating under different tip-speed ratios and yaw angles. Force and power measurements were performed to characterize the variation of thrust force (both magnitude and direction) and generated power of the wind turbine under different operating conditions. Moreover, flow measurements, collected using high-resolution particle-image velocimetry as well as hot-wire anemometry, were employed to systematically study the flow in the upwind, near-wake, and far-wake regions. These measurements provide new insights into the effect of turbine operating conditions on flow characteristics in these regions. For the upwind region, the results show a strong lateral asymmetry under yawed conditions. For the near-wake region, the evolution of tip and root vortices was studied with the use of both instantaneous and phase-averaged vorticity fields. The results suggest that the vortex breakdown position cannot be determined based on phase-averaged statistics, particularly for tip vortices under turbulent inflow conditions. Moreover, the measurements in the near-wake region indicate a complex velocity distribution with a speed-up region in the wake center, especially for higher tip-speed ratios. In order to elucidate the meandering tendency of far wakes, particular focus was placed on studying the characteristics of large turbulent structures in the boundary layer and their interaction with wind turbines. Although these structures are elongated in the streamwise direction, their cross sections are found to have a size comparable to the rotor area, so that they can be affected by the presence of the turbine. In addition, the study of spatial coherence in turbine wakes reveals that any statistics based on streamwise velocity fluctuations cannot provide reliable information about the size of large turbulent structures in turbine wakes due to the effect of wake

Dalla disciplina del progetto, le ragioni di un percorso magistrale di studi in interaction design

Directory of Open Access Journals (Sweden)

Alessandra Bosco

2014-04-01

Full Text Available ITLa trasformazione del ruolo e della professione del designer nella condizione socio-economica culturale contemporanea, contraddistinta da una molteplicità di stimoli visivi, dal sovraffollamento dei prodotti, dall’uso di nuove tecnologie e dalla pervasività dei device, orienta la scelta di indirizzare un percorso di studi magistrale nell’ambito multidisciplinare dell’interaction design. La formazione specifica che si articola in maniera sinergica tra laboratori e corsi teorici trova fondamento nelle discipline dello human factors, delle teorie dell’interazione e della critica del design. Il paper argomenta le ragioni, i metodi e le scelte effettuate dal gruppo di docenti che tra il 2010 e il 2014 ha progettato tale percorso didattico all’Università degli Studi della Repubblica di San Marino.ENThe transformation of the designer’s role in the contemporary social, economic and cultural context, characterized by a growing overload of visual stimuli, new technological products, and a multitude of pervasive mobile devices, led the decision to steer the graduate degree programme in design towards the multidisciplinary field of interaction design. This specific branch of learning builds its fundamentals in the synergetic teaching of theoretical and studio courses focusing on human factors, theories of interaction and design criticism. This paper investigates the motivations, the methods and the choices made by a group of professors of the University of the Republic of San Marino to create a new graduate programme in interaction design.

Design And Implementation Of An Interactive Website; A Case Study ...

African Journals Online (AJOL)

An interactive website has been designed for the Department of Physics, University of Uyo, using Hypertext Markup Language (HTML) involving structuring, coding, and testing. This will enable the Department to gather, process, store and disseminate an up- to- date information to the whole world on the academic ...

The design and testing of interactive hospital spaces to meet the needs of waiting children.

Science.gov (United States)

Biddiss, Elaine; McPherson, Amy; Shea, Geoffrey; McKeever, Patricia

2013-01-01

To design an innovative interactive media display in a pediatric hospital clinic waiting space that addresses the growing demand for accessible, contact-surface-free options for play. In healthcare settings, waiting can be anxiety provoking for children and their accompanying family members. Opportunities for positive distraction have been shown to reduce waiting anxiety, leading to positive health outcomes. An interactive media display, ScreenPlay, was created and evaluated using a participatory design approach and a combination of techniques including quality function deployment and mixed data elicitation methods (questionnaires, focus groups, and observations). The user and organizational design requirements were established and used to review contemporary strategies for positive distraction in healthcare waiting spaces and to conceptualize and test ScreenPlay. Ten staff members, 11 children/youths, and 6 parents participated in the design and evaluation of ScreenPlay. ScreenPlay provided a positive, engaging experience without the use of contact surfaces through which infections can be spread. It was accessible to children, youth, and adults of all motor abilities. All participants strongly agreed that the interactive media display would improve the healthcare waiting experience. ScreenPlay is an interactive display that is the result of a successful model for the design of healthcare waiting spaces that is collaborative, interdisciplinary, and responsive to the needs of its community. Design process, healing environments, hospital, interdisciplinary, pediatric.

LOADS INTERACTION DOMAINS METHODOLOGY FOR THE DESIGN OF STEEL GREENHOUSE STRUCTURES

Directory of Open Access Journals (Sweden)

Sergio Castellano

2007-03-01

Full Text Available Aim of this research is to develop a design methodology which correlates main structural design parameters, whose production is characterised by high levels of standardization, such as the height of gutter or the distance between frames, with actions on the greenhouse. The methodology, based on the use of charts and abacus, permits a clear and a direct interpretation of the structural response to design load combinations and allows the design of structural improvements with the aim of the optimization of the ratio benefits (structural strength/costs. The study of structural interaction domains allowed a clear and a direct interpretation of the structural response to design load combinations. The diagrams highlight not only if the structure fulfils the standard requirements but also the safety levels with respect to design load combinations and allow the structural designer how to operate in order to optimize the structural response with standard requirements achieving the best ratio benefits (structural safety/ costs. The methodology was developed basing on criteria assigned by EN13031 on two different kinds of greenhouse structures: an arched greenhouse with a film plastic covering and a duo pitched roof greenhouse cover with rigid plastic membranes. Structural interaction domains for arched greenhouse showed a better capability of the structure to resist to vertical loads then to horizontal one. Moreover, the climatic load distribution on the structure assigned by EN13031 is such that the combination of climatic actions is less dangerous for the structure then their individual application. Whilst, duo pitched roof steel greenhouse interaction domains, showed a better capability of the structure to resist to vertical loads then to horizontal one and that, in any case, the serviceability limit states analysis is more strict then the ULS one. The shape of structural domains highlighted that the combination of actions is more dangerous for the

Considerations of fluid-structure interaction effects in the design of high-level waste storage tanks

International Nuclear Information System (INIS)

Stuart, R.J.; Shipley, L.E.; Ghose, A.; Hiremath, M.S.

1994-01-01

For the seismic evaluation and design of the large number of underground high-level waste storage tanks (HLWST) at DOE sites, an important consideration is the adequate estimation of the fluid-structure interaction effects on the design forces. The DOE Tanks Seismic Experts Panel (TSEP) has developed seismic design and evaluation guidelines which include simplified methods for estimating hydrodynamic effects on tanks. For the practical analysis and design of HLWSTs, however, more sophisticated methods are often needed. The research presented in this paper demonstrates the effectiveness and reliability of finite element method based techniques, developed and utilized by ARES, to evaluate the fluid-structure interaction effects on underground HLWSTs. Analysis results for simple cylindrical tank configurations are first compared with previously published data, to benchmark the techniques. Next, for an actual HLWST configuration, correlations are established between these techniques and the TSEP guidelines, for the design parameters affected by fluid-structure interaction. Finally, practical design situations which may require a level of analysis sophistication that goes beyond the simplified TSEP guidelines are presented. This level of sophistication is frequently required when attempting to validate or upgrade the design qualifications of existing tanks

Development of MCAERO wing design panel method with interactive graphics module

Science.gov (United States)

Hawk, J. D.; Bristow, D. R.

1984-01-01

A reliable and efficient iterative method has been developed for designing wing section contours corresponding to a prescribed subcritical pressure distribution. The design process is initialized by using MCAERO (MCAIR 3-D Subsonic Potential Flow Analysis Code) to analyze a baseline configuration. A second program DMCAERO is then used to calculate a matrix containing the partial derivative of potential at each control point with respect to each unknown geometry parameter by applying a first-order expansion to the baseline equations in MCAERO. This matrix is calculated only once but is used in each iteration cycle to calculate the geometry perturbation and to analyze the perturbed geometry. The potential on the new geometry is calculated by linear extrapolation from the baseline solution. This extrapolated potential is converted to velocity by numerical differentiation, and velocity is converted to pressure by using Bernoulli's equation. There is an interactive graphics option which allows the user to graphically display the results of the design process and to interactively change either the geometry or the prescribed pressure distribution.

Logic of quench protection assembly for BEPC II interaction region superconducting magnet

International Nuclear Information System (INIS)

Chen Fusan; Cheng Jian

2006-01-01

Two superconducting magnet complexes are used in BEPC II interaction region. The corresponding quench protection system divides all related faults into two classes and takes different protection actions according to the urgency degree. Since BEPC II has two operating modes and the superconducting magnets use different power supplies in different operating modes, the quench protection system must take the mode switching into consideration. (authors)

Using Tablet PCs and Interactive Software in IC Design Courses to Improve Learning

Science.gov (United States)

Simoni, M.

2011-01-01

This paper describes an initial study of using tablet PCs and interactive course software in integrated circuit (IC) design courses. A rapidly growing community is demonstrating how this technology can improve learning and retention of material by facilitating interaction between faculty and students via cognitive exercises during lectures. While…

SCOWLP classification: Structural comparison and analysis of protein binding regions

Directory of Open Access Journals (Sweden)

Anders Gerd

2008-01-01

Full Text Available Abstract Background Detailed information about protein interactions is critical for our understanding of the principles governing protein recognition mechanisms. The structures of many proteins have been experimentally determined in complex with different ligands bound either in the same or different binding regions. Thus, the structural interactome requires the development of tools to classify protein binding regions. A proper classification may provide a general view of the regions that a protein uses to bind others and also facilitate a detailed comparative analysis of the interacting information for specific protein binding regions at atomic level. Such classification might be of potential use for deciphering protein interaction networks, understanding protein function, rational engineering and design. Description Protein binding regions (PBRs might be ideally described as well-defined separated regions that share no interacting residues one another. However, PBRs are often irregular, discontinuous and can share a wide range of interacting residues among them. The criteria to define an individual binding region can be often arbitrary and may differ from other binding regions within a protein family. Therefore, the rational behind protein interface classification should aim to fulfil the requirements of the analysis to be performed. We extract detailed interaction information of protein domains, peptides and interfacial solvent from the SCOWLP database and we classify the PBRs of each domain family. For this purpose, we define a similarity index based on the overlapping of interacting residues mapped in pair-wise structural alignments. We perform our classification with agglomerative hierarchical clustering using the complete-linkage method. Our classification is calculated at different similarity cut-offs to allow flexibility in the analysis of PBRs, feature especially interesting for those protein families with conflictive binding regions

Design of the central region in the Warsaw K-160 cyclotron

CERN Document Server

Toprek, D; Choinski, J; Czosnyka, T

2001-01-01

This paper describes the design of the central region for h=2 and 3 modes of acceleration in the Warsaw K-160 cyclotron. The central region is unique and compatible with the two above-mentioned harmonic modes of operation. Only one spiral type inflector will be used. The electric field distribution in the inflector and in the four acceleration gaps has been numerically calculated from an electric potential map produced by the program RELAX3D. The geometry of the central region has been tested with the computations of orbits carried out by means of the computer code CYCLONE. The optical properties of the spiral inflector and the central region were studied by using the programs CASINO and CYCLONE, respectively.

Design of the central region in the Warsaw K-160 cyclotron

International Nuclear Information System (INIS)

Toprek, D.; Sura, Josef; Choinski, Jaroslav; Czosnyka, Tomas

2001-01-01

This paper describes the design of the central region for h=2 and 3 modes of acceleration in the Warsaw K-160 cyclotron. The central region is unique and compatible with the two above-mentioned harmonic modes of operation. Only one spiral type inflector will be used. The electric field distribution in the inflector and in the four acceleration gaps has been numerically calculated from an electric potential map produced by the program RELAX3D. The geometry of the central region has been tested with the computations of orbits carried out by means of the computer code CYCLONE. The optical properties of the spiral inflector and the central region were studied by using the programs CASINO and CYCLONE, respectively

Interactive Multimedia-Based Animation: A Study of Effectiveness on Fashion Design Technology Learning

Science.gov (United States)

Wiana, W.

2018-01-01

The learning process is believed will reach optimal results if facilitated by diversity of learning’s device from aspects of the approach, method, media or it’s evaluation system, in individually, groups, or as well as classical. One of the learning’s Device can be developed in an attempt to improve the results of the study is Computer Based Learning (CBL). CBL was developed aim to help students to understand the concepts of the learning material which presented interactively by the system and able to provide information and learning process better. This research is closely related to efforts to improve the quality of Fashion design in digital format learning, with specific targets to generate interactive multimedia-based animation as effective media and learning resources for fashion design learning. Applications that are generated may be an option for delivering learning material as well as to engender interest in learning as well as understanding with students against the subject matter so that it can improve the learning achievements of students. The instruments used to collect data is a test sheet of mastering the concept which developed on the basis of indicators understanding the concept of fashion design, the material elements and principles of fashion design as well as application on making fashion design. As for the skills test is done through test performance to making fashion design in digital format. The results of testing against the mastery of concepts and skills of fashion designing in digital formatted shows that experimental group obtained significantly higher qualifications compared to the control group. That means that the use of interactive multimedia-based animation, effective to increased mastery of concepts and skills on making fashion design in digital format.

Atypical energetic particle events observed prior energetic particle enhancements associated with corotating interaction regions

Science.gov (United States)

Khabarova, Olga; Malandraki, Olga; Zank, Gary; Jackson, Bernard; Bisi, Mario; Desai, Mihir; Li, Gang; le Roux, Jakobus; Yu, Hsiu-Shan

2017-04-01

Recent studies of mechanisms of particle acceleration in the heliosphere have revealed the importance of the comprehensive analysis of stream-stream interactions as well as the heliospheric current sheet (HCS) - stream interactions that often occur in the solar wind, producing huge magnetic cavities bounded by strong current sheets. Such cavities are usually filled with small-scale magnetic islands that trap and re-accelerate energetic particles (Zank et al. ApJ, 2014, 2015; le Roux et al. ApJ, 2015, 2016; Khabarova et al. ApJ, 2015, 2016). Crossings of these regions are associated with unusual variations in the energetic particle flux up to several MeV/nuc near the Earth's orbit. These energetic particle flux enhancements called "atypical energetic particle events" (AEPEs) are not associated with standard mechanisms of particle acceleration. The analysis of multi-spacecraft measurements of energetic particle flux, plasma and the interplanetary magnetic field shows that AEPEs have a local origin as they are observed by different spacecraft with a time delay corresponding to the solar wind propagation from one spacecraft to another, which is a signature of local particle acceleration in the region embedded in expanding and rotating background solar wind. AEPEs are often observed before the arrival of corotating interaction regions (CIRs) or stream interaction regions (SIRs) to the Earth's orbit. When fast solar wind streams catch up with slow solar wind, SIRs of compressed heated plasma or more regular CIRs are created at the leading edge of the high-speed stream. Since coronal holes are often long-lived structures, the same CIR re-appears often for several consecutive solar rotations. At low heliographic latitudes, such CIRs are typically bounded by forward and reverse waves on their leading and trailing edges, respectively, that steepen into shocks at heliocentric distances beyond 1 AU. Energetic ion increases have been frequently observed in association with CIR

Design, testing, and delivery of an interactive graphics display subsystem

Science.gov (United States)

Holmes, B.

1973-01-01

An interactive graphics display system was designed to be used in locating components on a printed circuit card and outputting data concerning their thermal values. The manner in which this was accomplished in terms of both hardware and software is described. An analysis of the accuracy of this approach is also included.

Instructional Design to Measure the Efficacy of Interactive E-Books in A High School Setting

Directory of Open Access Journals (Sweden)

Maria Victoria PABRUA BATOON

2018-04-01

Full Text Available This article describes a qualitative research analysis on the implementation of interactive e-books in high school courses using a case study approach. The subjects of the study included seven professors and 16 freshmen who were surveyed and interviewed with a questionnaire designed according to the Kemp Model of Instructional Design. The study revealed that participants use interactive e-books as a technological educational resource. The professors pointed out that the design of the interactive e-books helped students develop essential learning skills: technological ability, reading and writing skills, as well as cognition and metacognition abilities. Furthermore, the students noted that the use of interactive e-books has a positive effect on their grades due to its high audio and visual contents. However, the students indicated that they were allured to chat, to play or to navigate in their mobile device while they were using it. Finally, this study can contribute to the relative knowledge about the use of mobile technology in education, as well as, it aids the professor to make a reflection about the Instructional Design of the educational technological resources used in the classroom to promote better result in the process of learning.

An intelligent and interactive carpet role of design in a textile innovation project

NARCIS (Netherlands)

Deckers, E.J.L.; Stouw, van der B.; Peutz, J.

2012-01-01

This paper presents an ongoing innovation project on the development of an intelligent and interactive carpet called PeR+, short for Perception Rug Plus. This design-research project is a collaboration between an international flooring company, DESSO, and the Department of Industrial Design at the

Helping Hands: Designing Video Games with Interpersonal Touch Interaction

OpenAIRE

Watts , Cody; Sharlin , Ehud; Woytiuk , Peter

2010-01-01

International audience; Increasingly, the movements of players' physical bodies are being used as a method of controlling and playing video games. This trend is evidenced by the recent development of interpersonal touch-based games; multiplayer games which players control by physically touching their partners. Although a small number of interpersonal touch-based games have recently been designed, the best practices for creating video games based on this unconventional interaction technique re...

Exploratory shaft conceptual design report: Gulf Interior Region salt domes

International Nuclear Information System (INIS)

1983-07-01

This conceptual design report summarizes the conceptualized design for an exploratory shaft facility at a representative site in the Gulf Interior Region of the United States (Louisiana and Mississippi). Conceptualized designs for other possible locations (Paradox Basin in Utah and Permian Basin in Texas) are summarized in separate reports. The purpose of the exploratory shaft facility is to provide access to the reference repository horizon to permit in-situ testing of the salt. The in-situ testing is necessary to verify repository salt design parameters, evaluate isotropy and homoqeneity of the salt, and provide a demonstration of the constructability and confirmation of the design to gain access to the repository. The fundamental purpose of this conceptual design report is to assure the feasibility of the exploratory shaft project and to develop a reliable cost estimate and realistic schedule. Because a site has not been selected and site-specific subsurface data are not available, it has been necessary to make certain assumptions in order to develop a conceptural design for an exploratory shaft facility in salt. As more definitive information becomes available to support the design process, adjustments in the projected schedule and estimated costs will be required

Examining the role of policy design and policy interaction in EU automotive emissions performance gaps

International Nuclear Information System (INIS)

Skeete, Jean-Paul

2017-01-01

In the wake of the 2015 ‘Dieselgate’ scandal, the US and European governments publicly confronted automakers about their behaviour, which raised concerns about the integrity of the current emissions legislation regimes. In this article, I argue that ‘flexibilities’ within the EU's emissions legislative framework afforded automakers the opportunity to legally sidestep strict performance standards laid out in the law and resulted in a significant performance gap in real world driving emissions. This article provides a timely examination of EU emission legislation policy design and policy interaction within the European Union with the aim of explaining why the EU policy framework failed to regulate the regional automotive industry. Current research is mostly concerned with the typology and effectiveness of individual environmental policy instruments, be it regulatory or economic incentives, that aim to influence industry behaviour. This article approaches the current EU policy regime in a more holistic manner and focuses on the exploitation of weaknesses in the regulatory framework by private firms, which has received little academic attention in the innovation and transition literature. A major contribution of this article therefore is a body of primary qualitative interview data from industry elites concerning relevant emissions policies. - Highlights: • Significant performance gaps exist between stated and real-world car emissions. • Real-world performance gaps exist due to exploitation of flawed EU policy design. • Diesels have the widest performance gaps and are most harmful to air quality. • Policy interaction compounds EU air quality problems and promotes path-dependency. • Closing performance gaps requires policy revisions and more enforcement autonomy.

Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6.

Science.gov (United States)

Kim, Han Ie; Jung, Jinwon; Lee, Eun-Saem; Kim, Yong-Chul; Lee, Weontae; Lee, Seung-Taek

2007-11-03

PTK6 (also known as Brk) is an intracellular tyrosine kinase that contains SH3, SH2, and tyrosine kinase catalytic (Kinase) domains. The SH3 domain of PTK6 interacts with the N-terminal half of the linker (Linker) region between the SH2 and Kinase domains. Site-directed mutagenesis and surface plasmon resonance studies showed that a tryptophan residue (Trp44) in the SH3 domain and proline residues in the Linker region, in the order of Pro177, Pro175, and Pro179, contribute to the interaction. The three-dimensional modeled structure of the SH3-Linker complex was in agreement with the biochemical data. Disruption of the intramolecular interaction between the SH3 domain and the Linker region by mutation of Trp44, Pro175, Pro177, and Pro179 markedly increased the catalytic activity of PTK6 in HEK 293 cells. These results demonstrate that Trp44 in the SH3 domain and Pro177, Pro175, and Pro179 in the N-terminal half of the Linker region play important roles in the SH3-Linker interaction to maintain the protein in an inactive conformation along with the phosphorylated Tyr447-SH2 interaction.

Interactive Development of Regional Climate Web Pages for the Western United States

Science.gov (United States)

Oakley, N.; Redmond, K. T.

2013-12-01

Weather and climate have a pervasive and significant influence on the western United States, driving a demand for information that is ongoing and constantly increasing. In communications with stakeholders, policy makers, researchers, educators, and the public through formal and informal encounters, three standout challenges face users of weather and climate information in the West. First, the needed information is scattered about the web making it difficult or tedious to access. Second, information is too complex or requires too much background knowledge to be immediately applicable. Third, due to complex terrain, there is high spatial variability in weather, climate, and their associated impacts in the West, warranting information outlets with a region-specific focus. Two web sites, TahoeClim and the Great Basin Weather and Climate Dashboard were developed to overcome these challenges to meeting regional weather and climate information needs. TahoeClim focuses on the Lake Tahoe Basin, a region of critical environmental concern spanning the border of Nevada and California. TahoeClim arose out of the need for researchers, policy makers, and environmental organizations to have access to all available weather and climate information in one place. Additionally, TahoeClim developed tools to both interpret and visualize data for the Tahoe Basin with supporting instructional material. The Great Basin Weather and Climate Dashboard arose from discussions at an informal meeting about Nevada drought organized by the USDA Farm Service Agency. Stakeholders at this meeting expressed a need to take a 'quick glance' at various climate indicators to support their decision making process. Both sites were designed to provide 'one-stop shopping' for weather and climate information in their respective regions and to be intuitive and usable by a diverse audience. An interactive, 'co-development' approach was taken with sites to ensure needs of potential users were met. The sites were

Interaction for Innovation: Comparing Norwegian Regions

Directory of Open Access Journals (Sweden)

Marina Solesvik

2014-01-01

Full Text Available Building upon insights from earlier investigations of innovation collaboration from a regional perspective as well as the triple helix perspective, local/regional innovation systems and open innovation approaches, this study explores whether cooperation between firms, universities and government increases the intensity of innovation equally for the capital city and peripheral regions. We investigate whether firms located in the capital region benefit more from public support, cooperation with universities, and cooperation with different stakeholders than firms located in peripheral regions. Using logistic binary regressions, we find that capital region firms are generally not more innovative than those located elsewhere. We also find no effect on innovation from cooperation with universities, although public support is related to engagement in product and process innovations. Our results warn against simple applications of triple helix and open innovation approaches, as many forms of collaboration seem to have little impact on innovation, regardless of regional context.

Interaction effects of region-level GDP per capita and age on labour market transition rates in Italy

Directory of Open Access Journals (Sweden)

Luca Zanin

2017-04-01

Full Text Available Abstract The aim of this paper is to measure the effect of the interaction between age for the population of males and females aged 18 to 74 and region-level GDP per capita on labour market transition probabilities in Italy. We compare different occupational states in a sample of males and females who remained in their region of residence at two points in time (12 months apart. We estimate the transition probabilities using a flexible hierarchical logit model with interaction effects between worker age and region-level GDP per capita. We apply this model using longitudinal data from the Italian Labour Force Survey that cover the 2004–2013 period. We find empirical support for the assumption that people in the same age cohort have different labour market opportunities based on the level of GDP per capita in their region of residence. These differences are particularly relevant among younger workers.

The ZAP Project: Designing Interactive Computer Tools for Learning Psychology

Science.gov (United States)

Hulshof, Casper; Eysink, Tessa; de Jong, Ton

2006-01-01

In the ZAP project, a set of interactive computer programs called "ZAPs" was developed. The programs were designed in such a way that first-year students experience psychological phenomena in a vivid and self-explanatory way. Students can either take the role of participant in a psychological experiment, they can experience phenomena themselves,…

An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

Energy Technology Data Exchange (ETDEWEB)

Mathew, Jose V., E-mail: josev.mathew@gmail.com; Rao, S.V.L.S.; Krishnagopal, S.; Singh, P.

2013-11-01

The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ∼16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ∼20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs. -- Highlights: • An improved permanent magnet quadrupole (PMQ) design with larger good field region is proposed. • We investigate four PMQ designs, including the widely used Halbach and bullet nosed designs. • Analytical calculations are backed by 2D as well as 3D numerical solvers, PANDIRA and RADIA. • The optimized 16 segment rectangular PMQ design is identified to exhibit the largest good field region. • The effect of easy axis orientation

An improved permanent magnet quadrupole design with larger good field region for high intensity proton linacs

International Nuclear Information System (INIS)

Mathew, Jose V.; Rao, S.V.L.S.; Krishnagopal, S.; Singh, P.

2013-01-01

The Low Energy High Intensity Proton Accelerator (LEHIPA), being developed at the Bhabha Atomic Research Centre (BARC) will produce a 20 MeV, 30 mA, continuous wave (CW) proton beam. At these low velocities, space-charge forces dominate, and could lead to larger beam sizes and beam halos. Hence in the design of the focusing lattice of the LEHIPA drift tube linac (DTL) using permanent magnet quadrupoles (PMQs), a larger good field region is preferred. Here we study, using the two dimensional (2D) and three dimensional (3D) simulation codes PANDIRA and RADIA, four different types of cylindrical PMQ designs: 16-segment trapezoidal Halbach configuration, bullet-nosed geometry and 8- and 16-segment rectangular geometries. The trapezoidal Halbach geometry is used in a variety of accelerators since it provides very high field gradients in small bores, while the bullet-nosed geometry, which is a combination of the trapezoidal and rectangular designs, is used in some DTLs. This study shows that a larger good field region is possible in the 16-segment rectangular design as compared to the Halbach and bullet-nosed designs, making it more attractive for high-intensity proton linacs. An improvement in good-field region by ∼16% over the Halbach design is obtained in the optimized 16-segment rectangular design, although the field gradient is lower by ∼20%. Tolerance studies show that the rectangular segment PMQ design is substantially less sensitive to the easy axis orientation errors and hence will be a better choice for DTLs. -- Highlights: • An improved permanent magnet quadrupole (PMQ) design with larger good field region is proposed. • We investigate four PMQ designs, including the widely used Halbach and bullet nosed designs. • Analytical calculations are backed by 2D as well as 3D numerical solvers, PANDIRA and RADIA. • The optimized 16 segment rectangular PMQ design is identified to exhibit the largest good field region. • The effect of easy axis orientation

Rational Design and Tuning of Functional RNA Switch to Control an Allosteric Intermolecular Interaction.

Science.gov (United States)

Endoh, Tamaki; Sugimoto, Naoki

2015-08-04

Conformational transitions of biomolecules in response to specific stimuli control many biological processes. In natural functional RNA switches, often called riboswitches, a particular RNA structure that has a suppressive or facilitative effect on gene expression transitions to an alternative structure with the opposite effect upon binding of a specific metabolite to the aptamer region. Stability of RNA secondary structure (-ΔG°) can be predicted based on thermodynamic parameters and is easily tuned by changes in nucleobases. We envisioned that tuning of a functional RNA switch that causes an allosteric interaction between an RNA and a peptide would be possible based on a predicted switching energy (ΔΔG°) that corresponds to the energy difference between the RNA secondary structure before (-ΔG°before) and after (-ΔG°after) the RNA conformational transition. We first selected functional RNA switches responsive to neomycin with predicted ΔΔG° values ranging from 5.6 to 12.2 kcal mol(-1). We then demonstrated a simple strategy to rationally convert the functional RNA switch to switches responsive to natural metabolites thiamine pyrophosphate, S-adenosyl methionine, and adenine based on the predicted ΔΔG° values. The ΔΔG° values of the designed RNA switches proportionally correlated with interaction energy (ΔG°interaction) between the RNA and peptide, and we were able to tune the sensitivity of the RNA switches for the trigger molecule. The strategy demonstrated here will be generally applicable for construction of functional RNA switches and biosensors in which mechanisms are based on conformational transition of nucleic acids.

Emotional engagement, social interactions, and the development of an afterschool game design curriculum

Science.gov (United States)

Kwah, Helen; Milne, Catherine; Tsai, Tzuchi; Goldman, Ricki; Plass, Jan L.

2016-09-01

This formative design study examines how a program curriculum and implementation was emergently (re)designed in dynamic relation to the expressed emotions of teachers and students. The context was a yearlong afterschool game design program for STEM learning at an urban and public all-girls middle school. Using Randall Collins' (Interaction ritual chains, Princeton University Press, Princeton, 2004) sociology of emotions framework, our analysis of field notes and video data reveal how the original intended curriculum hindered the generation of positive emotions, mutual foci of attention, and feelings of group solidarity—factors important in the generation of successful group interactions. In response to teacher and student expressed emotions, we took these factors as a guide for redesigning the program curriculum and implementation in order to foster a more positive emotional climate and redirect students' positive emotions toward engagement in learning goals. This study's implications point to the possibilities for designing curricula and program implementations to engender more emotionally responsive environments for STEM learning.

Aerosol-cloud interactions from urban, regional to global scales

International Nuclear Information System (INIS)

Wang, Yuan

2015-01-01

The studies in this dissertation aim at advancing our scientific understandings about physical processes involved in the aerosol-cloud-precipitation interaction and quantitatively assessing the impacts of aerosols on the cloud systems with diverse scales over the globe on the basis of the observational data analysis and various modeling studies. As recognized in the Fifth Assessment Report by the Inter-government Panel on Climate Change, the magnitude of radiative forcing by atmospheric aerosols is highly uncertain, representing the largest uncertainty in projections of future climate by anthropogenic activities. By using a newly implemented cloud microphysical scheme in the cloud-resolving model, the thesis assesses aerosol-cloud interaction for distinct weather systems, ranging from individual cumulus to mesoscale convective systems. This thesis also introduces a novel hierarchical modeling approach that solves a long outstanding mismatch between simulations by regional weather models and global climate models in the climate modeling community. More importantly, the thesis provides key scientific solutions to several challenging questions in climate science, including the global impacts of the Asian pollution. As scientists wrestle with the complexities of climate change in response to varied anthropogenic forcing, perhaps no problem is more challenging than the understanding of the impacts of atmospheric aerosols from air pollution on clouds and the global circulation.

Aerosol-cloud interactions from urban, regional to global scales

Energy Technology Data Exchange (ETDEWEB)

Wang, Yuan [California Institute of Technology, Pasadena, CA (United States). Seismological Lab.

2015-10-01

The studies in this dissertation aim at advancing our scientific understandings about physical processes involved in the aerosol-cloud-precipitation interaction and quantitatively assessing the impacts of aerosols on the cloud systems with diverse scales over the globe on the basis of the observational data analysis and various modeling studies. As recognized in the Fifth Assessment Report by the Inter-government Panel on Climate Change, the magnitude of radiative forcing by atmospheric aerosols is highly uncertain, representing the largest uncertainty in projections of future climate by anthropogenic activities. By using a newly implemented cloud microphysical scheme in the cloud-resolving model, the thesis assesses aerosol-cloud interaction for distinct weather systems, ranging from individual cumulus to mesoscale convective systems. This thesis also introduces a novel hierarchical modeling approach that solves a long outstanding mismatch between simulations by regional weather models and global climate models in the climate modeling community. More importantly, the thesis provides key scientific solutions to several challenging questions in climate science, including the global impacts of the Asian pollution. As scientists wrestle with the complexities of climate change in response to varied anthropogenic forcing, perhaps no problem is more challenging than the understanding of the impacts of atmospheric aerosols from air pollution on clouds and the global circulation.

Delineation of the calcineurin-interacting region of cyclophilin B.

Science.gov (United States)

Carpentier, M; Allain, F; Haendler, B; Slomianny, M C; Spik, G

2000-12-01

The immunosuppressant drug cyclosporin A (CsA) inhibits T-cell function by blocking the phosphatase activity of calcineurin. This effect is mediated by formation of a complex between the drug and cyclophilin (CyP), which creates a composite surface able to make high-affinity contacts with calcineurin. In vitro, the CyPB/CsA complex is more effective in inhibiting calcineurin than the CyPA/CsA and CyPC/CsA complexes, pointing to fine structural differences in the calcineurin-binding region. To delineate the calcineurin-binding region of CyPB, we mutated several amino acids, located in two loops corresponding to CyPA regions known to be involved, as follows: R76A, G77H, D155R, and D158R. Compared to wild-type CyPB, the G77H, D155R, and D158R mutants had intact isomerase and CsA-binding activities, indicating that no major conformational changes had taken place. When complexed to CsA, they all displayed only reduced affinity for calcineurin and much decreased inhibition of calcineurin phosphatase activity. These results strongly suggest that the three amino acids G77, D155, and D158 are directly involved in the interaction of CyPB/CsA with calcineurin, in agreement with their exposed position. The G77, D155, and D158 residues are not maintained in CyPA and might therefore account for the higher affinity of the CyPB/CsA complex for calcineurin.

Interdisciplinary Interactions During R&D and Early Design of Large Engineered Systems

Science.gov (United States)

McGowan, Anna-Maria Rivas

2014-01-01

Designing Large-Scale Complex Engineered Systems (LaCES) such as aircraft and submarines requires the input of thousands of engineers and scientists whose work is proximate in neither time nor space. Comprehensive knowledge of the system is dispersed among specialists whose expertise is in typically one system component or discipline. This study examined the interactive work practices among such specialists seeking to improve engineering practice through a rigorous and theoretical understanding of current practice. This research explored current interdisciplinary practices and perspectives during R&D and early LaCES design and identified why these practices and perspectives prevail and persist. The research design consisted of a three-fold, integrative approach that combined an open-ended survey, semi-structured interviews, and ethnography. Significant empirical data from experienced engineers and scientists in a large engineering organization were obtained and integrated with theories from organization science and engineering. Qualitative analysis was used to obtain a holistic, contextualized understanding. The over-arching finding is that issues related to cognition, organization, and social interrelations mostly dominate interactions across disciplines. Engineering issues, such as the integration of hardware or physics-based models, are not as significant. For example, organization culture is an important underlying factor that guided researchers more toward individual sovereignty over cross-disciplinarity. The organization structure and the engineered system architecture also serve as constraints to the engineering work. Many differences in work practices were observed, including frequency and depth of interactions, definition or co-construction of requirements, clarity or creation of the system architecture, work group proximity, and cognitive challenges. Practitioners are often unaware of these differences resulting in confusion and incorrect assumptions

HOM [higher order mode] losses at the IR [interaction region] of the B-factory

International Nuclear Information System (INIS)

Heifets, S.

1990-08-01

Masking at the interaction region (IR) will presumably reduce the synchrotron radiation background in the detector. One possible layout of the IR for B-factory shows a rather complicated system of masks. A bunch passing each mask will generate RF waves. These waves (called usually higher order modes, HOM-s) will be absorbed in the beam pipe wall producing additional heating and, interacting with the beam, kicking particles in the radial and azimuthal directions. This may change the bunch motion and its emittance. These effects are estimated in the present note

Dimensionless Analysis for Designing Domestic Rainwater Harvesting Systems at the Regional Level in Northern Taiwan

Directory of Open Access Journals (Sweden)

Chao-Hsien Liaw

2014-12-01

Full Text Available A regional-level and dimensionless analysis for designing a domestic rainwater harvesting system (DRWHS was developed. To consider various combinations of water demand, storage capacity, effective roof area, and rainfall in DRWHS design, two dimensionless ratios were used, namely, demand fraction and storage fraction, along with a relationship between the two ratios. Firstly, Northern Taiwan was divided into four sub-regions through cluster analysis based on the average annual 10-day rainfall distribution at rainfall stations and administrative districts. Easy-to-use dimensionless curves between demand fraction and storage fraction were obtained for five rainwater supply reliabilities of the DRWHS for the four sub-regions. Based on the dimensionless curves, a nomogram was constructed for designing DRWHSs at a rainwater supply reliability of 95% in the sub-region I. Storage capacities determined from the dimensionless curves showed a close fit with those determined from simulated values, but were larger than the values estimated from the method presented in the Green Building Evaluation Manual in most situations. The methodology developed herein can be used effectively for the preliminary design of a DRWHS and for overcoming the difficulties faced in designing a DRWHS without rainfall data and with incomplete rainfall data.

Exploring Interaction Space as Abstraction Mechanism for Task-Based User Interface Design

DEFF Research Database (Denmark)

Nielsen, C. M.; Overgaard, M.; Pedersen, M. B.

2007-01-01

Designing a user interface is often a complex undertaking. Model-based user interface design is an approach where models and mappings between them form the basis for creating and specifying the design of a user interface. Such models usually include descriptions of the tasks of the prospective user......, but there is considerable variation in the other models that are employed. This paper explores the extent to which the notion of interaction space is useful as an abstraction mechanism to reduce the complexity of creating and specifying a user interface design. We present how we designed a specific user interface through...... mechanism that can help user interface designers exploit object-oriented analysis results and reduce the complexity of designing a user interface....

Sikorsky interactive graphics surface design/manufacturing system

Science.gov (United States)

Robbins, R.

1975-01-01

An interactive graphics system conceived to be used in the design, analysis, and manufacturing of aircraft components with free form surfaces was described. In addition to the basic surface definition and viewing capabilities inherent in such a system, numerous other features are present: surface editing, automated smoothing of control curves, variable milling patch boundary definitions, surface intersection definition and viewing, automatic creation of true offset surfaces, digitizer and drafting machine interfaces, and cutter path optimization. Documented costs and time savings of better than six to one are being realized with this system. The system was written in FORTRAN and GSP for use on IBM 2250 CRT's in conjunction with an IBM 370/158 computer.

Design of the central region for axial injection in the VINCY cyclotron

International Nuclear Information System (INIS)

Milinkovic, L.; Toprek, D.

1996-01-01

This paper describes the design of the central region for h=1, h=2 and h=4 modes of acceleration in the VINCY cyclotron. The result which is worth reported in that the central region is unique and compatible with the three above mentioned harmonic modes of operation. Only one spiral type inflector will be used. The central region is designed to operate with two external ion sources: (a) an ECR ion source with the maximum extraction voltage of 25 kV for heavy ions, and (b) a multicusp ion source with the maximum extraction voltage of 30 kV for H - and D - ions. Heavy ions will be accelerated by the second and fourth harmonics, D - ions by the second harmonic and H - ions by the first harmonic of the RF field. The central region is equipped with an axial injection system. The electric field distribution in the inflector and in the four acceleration gaps has been numerically calculated from an electric potential map produced by the program RELAX3D. The geometry of the central region has been tested with the computations of orbits carried out by means of the computer code CYCLONE. The optical properties of the spiral inflector and the central region were studied by using the programs CASINO and CYCLONE respectively. We have also made an effort to minimize the inflector fringe field using the RELAX3D program. (orig.)

Optimal design of regional wastewater pipelines and treatment plant systems.

Science.gov (United States)

Brand, Noam; Ostfeld, Avi

2011-01-01

This manuscript describes the application of a genetic algorithm model for the optimal design of regional wastewater systems comprised of transmission gravitational and pumping sewer pipelines, decentralized treatment plants, and end users of reclaimed wastewater. The algorithm seeks the diameter size of the designed pipelines and their flow distribution simultaneously, the number of treatment plants and their size and location, the pump power, and the required excavation work. The model capabilities are demonstrated through a simplified example application using base runs and sensitivity analyses. Scaling of the proposed methodology to real life wastewater collection and treatment plants design problems needs further testing and developments. The model is coded in MATLAB using the GATOOL toolbox and is available from the authors.

Designing products as an integral part of choreography of interaction : the product's form as an integral part of movement

NARCIS (Netherlands)

Klooster, S.; Overbeeke, C.J.; Feijs, L.; Kyffin, S.; Young, B.

2005-01-01

Recent developments in design research concentrate on two themes (1) the unity of form, function and interaction and (2) the semantics of movement. The Design Movement approach incorporates unity of form, function and interaction through movement. Design Movement introduces the design of products as

Interannual-to-decadal air-sea interactions in the tropical Atlantic region

Science.gov (United States)

Ruiz-Barradas, Alfredo

2001-09-01

The present research identifies modes of atmosphere-ocean interaction in the tropical Atlantic region and the mechanisms by which air-sea interactions influence the regional climate. Novelties of the present work are (1)the use of relevant ocean and atmosphere variables important to identity coupled variability in the system. (2)The use of new data sets, including realistic diabatic heating. (3)The study of interactions between ocean and atmosphere relevant at interannual-to-decadal time scales. Two tropical modes of variability are identified during the period 1958-1993, the Atlantic Niño mode and the Interhemispheric mode. Those modes have defined structures in both ocean and atmosphere. Anomalous sea surface temperatures and winds are associated to anomalous placement of the Intertropical Convergence Zone (ITCZ). They develop maximum amplitude during boreal summer and spring, respectively. The anomalous positioning of the ITCZ produces anomalous precipitation in some places like Nordeste, Brazil and the Caribbean region. Through the use of a diagnostic primitive equation model, it is found that the most important terms controlling local anomalous surface winds over the ocean are boundary layer temperature gradients and diabatic heating anomalies at low levels (below 780 mb). The latter is of particular importance in the deep tropics in producing the anomalous meridional response to the surface circulation. Simulated latent heat anomalies indicate that a thermodynamic feedback establishes positive feedbacks at both sides of the equator and west of 20°W in the deep tropics and a negative feedback in front of the north west coast of Africa for the Interhemispheric mode. This thermodynamic feedback only establishes negative feedbacks for the Atlantic Niño mode. Transients establish some connection between the tropical Atlantic and other basins. Interhemispheric gradients of surface temperature in the tropical Atlantic influence winds in the midlatitude North

It's All Part of the Game: Video Game Interaction Design and Business Performance.

Science.gov (United States)

Shirinian, Ara

2001-01-01

Discusses the importance of positive video game experiences and designs that can create them, including immediacy of feedback, allowing graceful recovery from mistakes, high-quality feedback, and input device mappings. Examines interface complexity. Concludes game designers must treat the interaction between human and video game as a formal…

Correlation between safety assessments in the driver-car interaction design process.

Science.gov (United States)

Broström, Robert; Bengtsson, Peter; Axelsson, Jakob

2011-05-01

With the functional revolution in modern cars, evaluation methods to be used in all phases of driver-car interaction design have gained importance. It is crucial for car manufacturers to discover and solve safety issues early in the interaction design process. A current problem is thus to find a correlation between the formative methods that are used during development and the summative methods that are used when the product has reached the customer. This paper investigates the correlation between efficiency metrics from summative and formative evaluations, where the results of two studies on sound and navigation system tasks are compared. The first, an analysis of the J.D. Power and Associates APEAL survey, consists of answers given by about two thousand customers. The second, an expert evaluation study, was done by six evaluators who assessed the layouts by task completion time, TLX and Nielsen heuristics. The results show a high degree of correlation between the studies in terms of task efficiency, i.e. between customer ratings and task completion time, and customer ratings and TLX. However, no correlation was observed between Nielsen heuristics and customer ratings, task completion time or TLX. The results of the studies introduce a possibility to develop a usability evaluation framework that includes both formative and summative approaches, as the results show a high degree of consistency between the different methodologies. Hence, combining a quantitative approach with the expert evaluation method, such as task completion time, should be more useful for driver-car interaction design. Copyright © 2010 Elsevier Ltd and The Ergonomics Society. All rights reserved.

Interaction of impeller and guide vane in a series-designed axial-flow pump

International Nuclear Information System (INIS)

Kim, S; Choi, Y S; Lee, K Y; Kim, J H

2012-01-01

In this paper, the interaction of the impeller and guide vane in a series-designed axial-flow pump was examined through the implementation of a commercial CFD code. The impeller series design refers to the general design procedure of the base impeller shape which must satisfy the various flow rate and head requirements by changing the impeller setting angle and number of blades of the base impeller. An arc type meridional shape was used to keep the meridional shape of the hub and shroud with various impeller setting angles. The blade angle and the thickness distribution of the impeller were designed as an NACA airfoil type. In the design of the guide vane, it was necessary to consider the outlet flow condition of the impeller with the given setting angle. The meridional shape of the guide vane were designed taking into consideration the setting angle of the impeller, and the blade angle distribution of the guide vane was determined with a traditional design method using vane plane development. In order to achieve the optimum impeller design and guide vane, three-dimensional computational fluid dynamics and the DOE method were applied. The interaction between the impeller and guide vane with different combination set of impeller setting angles and number of impeller blades was addressed by analyzing the flow field of the computational results.

An object-oriented feature-based design system face-based detection of feature interactions

International Nuclear Information System (INIS)

Ariffin Abdul Razak

1999-01-01

This paper presents an object-oriented, feature-based design system which supports the integration of design and manufacture by ensuring that part descriptions fully account for any feature interactions. Manufacturing information is extracted from the feature descriptions in the form of volumes and Tool Access Directions, TADs. When features interact, both volumes and TADs are updated. This methodology has been demonstrated by developing a prototype system in which ACIS attributes are used to record feature information within the data structure of the solid model. The system implemented in the C++ programming language and embedded in a menu-driven X-windows user interface to the ACIS 3D Toolkit. (author)

Interaction in Balanced Cross Nested Designs

Science.gov (United States)

Ramos, Paulo; Mexia, João T.; Carvalho, Francisco; Covas, Ricardo

2011-09-01

Commutative Jordan Algebras, CJA, are used in the study of mixed models obtained, through crossing and nesting, from simpler ones. In the study of cross nested models the interaction between nested factors have been systematically discarded. However this can constitutes an artificial simplification of the models. We point out that, when two crossed factors interact, such interaction is symmetric, both factors playing in it equivalent roles, while when two nested factors interact, the interaction is determined by the nesting factor. These interactions will be called interactions with nesting. In this work we present a coherent formulation of the algebraic structure of models enabling the choice of families of interactions between cross and nested factors using binary operations on CJA.

THE MAIN TRENDS OF INTERACTION BETWEEN THE ADMINISTRATION OF ROSPOTREBNADZOR IN THE LENINGRAD REGION AND THE GOVERNMENT OF LENINGRAD REGION IN THE FIELD OF POPULATION RADIATION PROTECTION

Directory of Open Access Journals (Sweden)

S. A. Gorbanev

2008-01-01

Full Text Available The article gives the main interaction trends of the Administration of Rospotrebnadzor in the Leningrad Region and the Government of Leningrad Region regarding issues of regional radiation protection. It reports on comprehensive measures devoted to the limitation of the population exposure from natural irradiation sources, monitoring of territories which suffered from Chernobyl NPP accident and monitoring of the environmental impact of unauthorized dumps and solid municipal waste sites in the Leningrad Region. It presents the basic issues of medical exposure limitation in the Leningrad Region and measures for their solving.

A statistically rigorous sampling design to integrate avian monitoring and management within Bird Conservation Regions.

Science.gov (United States)

Pavlacky, David C; Lukacs, Paul M; Blakesley, Jennifer A; Skorkowsky, Robert C; Klute, David S; Hahn, Beth A; Dreitz, Victoria J; George, T Luke; Hanni, David J

2017-01-01

Monitoring is an essential component of wildlife management and conservation. However, the usefulness of monitoring data is often undermined by the lack of 1) coordination across organizations and regions, 2) meaningful management and conservation objectives, and 3) rigorous sampling designs. Although many improvements to avian monitoring have been discussed, the recommendations have been slow to emerge in large-scale programs. We introduce the Integrated Monitoring in Bird Conservation Regions (IMBCR) program designed to overcome the above limitations. Our objectives are to outline the development of a statistically defensible sampling design to increase the value of large-scale monitoring data and provide example applications to demonstrate the ability of the design to meet multiple conservation and management objectives. We outline the sampling process for the IMBCR program with a focus on the Badlands and Prairies Bird Conservation Region (BCR 17). We provide two examples for the Brewer's sparrow (Spizella breweri) in BCR 17 demonstrating the ability of the design to 1) determine hierarchical population responses to landscape change and 2) estimate hierarchical habitat relationships to predict the response of the Brewer's sparrow to conservation efforts at multiple spatial scales. The collaboration across organizations and regions provided economy of scale by leveraging a common data platform over large spatial scales to promote the efficient use of monitoring resources. We designed the IMBCR program to address the information needs and core conservation and management objectives of the participating partner organizations. Although it has been argued that probabilistic sampling designs are not practical for large-scale monitoring, the IMBCR program provides a precedent for implementing a statistically defensible sampling design from local to bioregional scales. We demonstrate that integrating conservation and management objectives with rigorous statistical

A statistically rigorous sampling design to integrate avian monitoring and management within Bird Conservation Regions.

Directory of Open Access Journals (Sweden)

David C Pavlacky

Full Text Available Monitoring is an essential component of wildlife management and conservation. However, the usefulness of monitoring data is often undermined by the lack of 1 coordination across organizations and regions, 2 meaningful management and conservation objectives, and 3 rigorous sampling designs. Although many improvements to avian monitoring have been discussed, the recommendations have been slow to emerge in large-scale programs. We introduce the Integrated Monitoring in Bird Conservation Regions (IMBCR program designed to overcome the above limitations. Our objectives are to outline the development of a statistically defensible sampling design to increase the value of large-scale monitoring data and provide example applications to demonstrate the ability of the design to meet multiple conservation and management objectives. We outline the sampling process for the IMBCR program with a focus on the Badlands and Prairies Bird Conservation Region (BCR 17. We provide two examples for the Brewer's sparrow (Spizella breweri in BCR 17 demonstrating the ability of the design to 1 determine hierarchical population responses to landscape change and 2 estimate hierarchical habitat relationships to predict the response of the Brewer's sparrow to conservation efforts at multiple spatial scales. The collaboration across organizations and regions provided economy of scale by leveraging a common data platform over large spatial scales to promote the efficient use of monitoring resources. We designed the IMBCR program to address the information needs and core conservation and management objectives of the participating partner organizations. Although it has been argued that probabilistic sampling designs are not practical for large-scale monitoring, the IMBCR program provides a precedent for implementing a statistically defensible sampling design from local to bioregional scales. We demonstrate that integrating conservation and management objectives with rigorous

Advances in Human-Computer Interaction: Graphics and Animation Components for Interface Design

Science.gov (United States)

Cipolla Ficarra, Francisco V.; Nicol, Emma; Cipolla-Ficarra, Miguel; Richardson, Lucy

We present an analysis of communicability methodology in graphics and animation components for interface design, called CAN (Communicability, Acceptability and Novelty). This methodology has been under development between 2005 and 2010, obtaining excellent results in cultural heritage, education and microcomputing contexts. In studies where there is a bi-directional interrelation between ergonomics, usability, user-centered design, software quality and the human-computer interaction. We also present the heuristic results about iconography and layout design in blogs and websites of the following countries: Spain, Italy, Portugal and France.

Mask locations in the SLC final focus region

International Nuclear Information System (INIS)

Cence, R.J.

1983-01-01

The location of four sets of masks needed to shield against background in the final focus region of the SLC is shown. The main point of this note is to update the results of Miller and Sens taking into account the recent changes that have been made in the optics of the SLC beams. For the latest beam design we use the TRANSPORT output dated 5-13-83. This design assumes that the final bends will form an S about the interaction point and that the final quadrupoles will be superconducting and will be placed about 8 feet from the interaction point

Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface

Science.gov (United States)

Chen, Ing-Chien; Lee, Yu-Ching; Chen, Jun-Bo; Tsai, Keng-Chang; Chen, Ching-Tai; Chang, Jeng-Yih; Yang, Ei-Wen; Hsu, Po-Chiang; Jian, Jhih-Wei; Hsu, Hung-Ju; Chang, Hung-Ju; Hsu, Wen-Lian; Huang, Kai-Fa; Ma, Alex Che; Yang, An-Suei

2012-01-01

Protein-protein interactions are critical determinants in biological systems. Engineered proteins binding to specific areas on protein surfaces could lead to therapeutics or diagnostics for treating diseases in humans. But designing epitope-specific protein-protein interactions with computational atomistic interaction free energy remains a difficult challenge. Here we show that, with the antibody-VEGF (vascular endothelial growth factor) interaction as a model system, the experimentally observed amino acid preferences in the antibody-antigen interface can be rationalized with 3-dimensional distributions of interacting atoms derived from the database of protein structures. Machine learning models established on the rationalization can be generalized to design amino acid preferences in antibody-antigen interfaces, for which the experimental validations are tractable with current high throughput synthetic antibody display technologies. Leave-one-out cross validation on the benchmark system yielded the accuracy, precision, recall (sensitivity) and specificity of the overall binary predictions to be 0.69, 0.45, 0.63, and 0.71 respectively, and the overall Matthews correlation coefficient of the 20 amino acid types in the 24 interface CDR positions was 0.312. The structure-based computational antibody design methodology was further tested with other antibodies binding to VEGF. The results indicate that the methodology could provide alternatives to the current antibody technologies based on animal immune systems in engineering therapeutic and diagnostic antibodies against predetermined antigen epitopes. PMID:22457753

Design, synthesis, and evaluation of an alpha-helix mimetic library targeting protein-protein interactions.

Science.gov (United States)

Shaginian, Alex; Whitby, Landon R; Hong, Sukwon; Hwang, Inkyu; Farooqi, Bilal; Searcey, Mark; Chen, Jiandong; Vogt, Peter K; Boger, Dale L

2009-04-22

The design and solution-phase synthesis of an alpha-helix mimetic library as an integral component of a small-molecule library targeting protein-protein interactions are described. The iterative design, synthesis, and evaluation of the candidate alpha-helix mimetic was initiated from a precedented triaryl template and refined by screening the designs for inhibition of MDM2/p53 binding. Upon identifying a chemically and biologically satisfactory design and consistent with the screening capabilities of academic collaborators, the corresponding complete library was assembled as 400 mixtures of 20 compounds (20 x 20 x 20-mix), where the added subunits are designed to mimic all possible permutations of the naturally occurring i, i + 4, i + 7 amino acid side chains of an alpha-helix. The library (8000 compounds) was prepared using a solution-phase synthetic protocol enlisting acid/base liquid-liquid extractions for purification on a scale that insures its long-term availability for screening campaigns. Screening of the library for inhibition of MDM2/p53 binding not only identified the lead alpha-helix mimetic upon which the library was based, but also suggests that a digestion of the initial screening results that accompany the use of such a comprehensive library can provide insights into the nature of the interaction (e.g., an alpha-helix mediated protein-protein interaction) and define the key residues and their characteristics responsible for recognition.

Instructional Design as Resource for the Strengthening of the Regional Identity

Directory of Open Access Journals (Sweden)

Carol del Carmen Terán González

2017-05-01

Full Text Available The present investigation takes as a fundamental goal, the elaboration of an instructional digital design that contributes to the strengthening of the regional identity of the students. The study is based on the theoretical postulates of: UNESCO (2004, CBN (1997, Ausubel (1983, Vygotsky, Rodríguez (2001, Careaga (2001, Galvis (1992, Pastorini, (2000, Salazar (2008, Rosario (2005, Bernice McCarthy (1987, among others. The same one, adopted the type of descriptive investigation, with a field design placed in the modality of viable project. The population is constituted by 12 teachers, and 40 students of the sixth degree. For the diagnostic phase a questionnaire will be applied with 14 items for teachers and students, the validation will be of content across the experts' judgment. In conclusion, there exists weakness for the constitutive elements of the historical memory as part of the regional identity.

Southern Regional Center for Lightweight Innovative Design

Energy Technology Data Exchange (ETDEWEB)

Wang, Paul T. [Mississippi State Univ., Mississippi State, MS (United States)

2012-12-01

The Southern Regional Center for Lightweight Innovative Design (SRCLID) has developed an experimentally validated cradle-to-grave modeling and simulation effort to optimize automotive components in order to decrease weight and cost, yet increase performance and safety in crash scenarios. In summary, the three major objectives of this project are accomplished: To develop experimentally validated cradle-to-grave modeling and simulation tools to optimize automotive and truck components for lightweighting materials (aluminum, steel, and Mg alloys and polymer-based composites) with consideration of uncertainty to decrease weight and cost, yet increase the performance and safety in impact scenarios; To develop multiscale computational models that quantify microstructure-property relations by evaluating various length scales, from the atomic through component levels, for each step of the manufacturing process for vehicles; and To develop an integrated K-12 educational program to educate students on lightweighting designs and impact scenarios. In this final report, we divided the content into two parts: the first part contains the development of building blocks for the project, including materials and process models, process-structure-property (PSP) relationship, and experimental validation capabilities; the second part presents the demonstration task for Mg front-end work associated with USAMP projects.

Interactive design optimization of magnetorheological-brake actuators using the Taguchi method

Science.gov (United States)

Erol, Ozan; Gurocak, Hakan

2011-10-01

This research explored an optimization method that would automate the process of designing a magnetorheological (MR)-brake but still keep the designer in the loop. MR-brakes apply resistive torque by increasing the viscosity of an MR fluid inside the brake. This electronically controllable brake can provide a very large torque-to-volume ratio, which is very desirable for an actuator. However, the design process is quite complex and time consuming due to many parameters. In this paper, we adapted the popular Taguchi method, widely used in manufacturing, to the problem of designing a complex MR-brake. Unlike other existing methods, this approach can automatically identify the dominant parameters of the design, which reduces the search space and the time it takes to find the best possible design. While automating the search for a solution, it also lets the designer see the dominant parameters and make choices to investigate only their interactions with the design output. The new method was applied for re-designing MR-brakes. It reduced the design time from a week or two down to a few minutes. Also, usability experiments indicated significantly better brake designs by novice users.

Interactive design optimization of magnetorheological-brake actuators using the Taguchi method

International Nuclear Information System (INIS)

Erol, Ozan; Gurocak, Hakan

2011-01-01

This research explored an optimization method that would automate the process of designing a magnetorheological (MR)-brake but still keep the designer in the loop. MR-brakes apply resistive torque by increasing the viscosity of an MR fluid inside the brake. This electronically controllable brake can provide a very large torque-to-volume ratio, which is very desirable for an actuator. However, the design process is quite complex and time consuming due to many parameters. In this paper, we adapted the popular Taguchi method, widely used in manufacturing, to the problem of designing a complex MR-brake. Unlike other existing methods, this approach can automatically identify the dominant parameters of the design, which reduces the search space and the time it takes to find the best possible design. While automating the search for a solution, it also lets the designer see the dominant parameters and make choices to investigate only their interactions with the design output. The new method was applied for re-designing MR-brakes. It reduced the design time from a week or two down to a few minutes. Also, usability experiments indicated significantly better brake designs by novice users

A GOAL QUESTION METRIC (GQM APPROACH FOR EVALUATING INTERACTION DESIGN PATTERNS IN DRAWING GAMES FOR PRESCHOOL CHILDREN

Directory of Open Access Journals (Sweden)

Dana Sulistiyo Kusumo

2017-06-01

Full Text Available In recent years, there has been an increasing interest to use smart devices’ drawing games for educational benefit. In Indonesia, our government classifies children age four to six years old as preschool children. Not all preschool children can use drawing games easily. Further, drawing games may not fulfill all Indonesia's preschool children’s drawing competencies. This research proposes to use Goal-Question Metric (GQM to investigate and evaluate interaction design patterns of preschool children in order to achieve the drawing competencies for preschool children in two drawing Android-based games: Belajar Menggambar (in English: Learn to Draw and Coret: Belajar Menggambar (in English: Scratch: Learn to Draw. We collected data from nine students of a preschool children education in a user research. The results show that GQM can assist to evaluate interaction design patterns in achieving the drawing competencies. Our approach can also yield interaction design patterns by comparing interaction design patterns in two drawing games used.

A large-scale soil-structure interaction experiment: Part I design and construction

International Nuclear Information System (INIS)

Tang, H.T.; Tang, Y.K.; Wall, I.B.; Lin, E.

1987-01-01

In the simulated earthquake experiments (SIMQUAKE) sponsored by EPRI, the detonation of vertical arrays of explosives propagated wave motions through the ground to the model structures. Although such a simulation can provide information about dynamic soil-structure interaction (SSI) characteristics in a strong motion environment, it lacks seismic wave scattering characteristics for studying seismic input to the soil-structure system and the effect of different kinds of wave composition to the soil-structure response. To supplement the inadequacy of the simulated earthquake SSI experiment, the Electric Power Research Institute (EPRI) and the Taiwan Power Company (Taipower) jointly sponsored a large scale SSI experiment in the field. The objectives of the experiment are: (1) to obtain actual strong motion earthquakes induced database in a soft-soil environment which will substantiate predictive and design SSI models;and (2) to assess nuclear power plant reactor containment internal components dynamic response and margins relating to actual earthquake-induced excitation. These objectives are accomplished by recording and analyzing data from two instrumented, scaled down, (1/4- and 1/12-scale) reinforced concrete containments sited in a high seismic region in Taiwan where a strong-motion seismic array network is located

A Randomized Trial Comparing Classical Participatory Design to VandAID, an Interactive CrowdSourcing Platform to Facilitate User-centered Design.

Science.gov (United States)

Dufendach, Kevin R; Koch, Sabine; Unertl, Kim M; Lehmann, Christoph U

2017-10-26

Early involvement of stakeholders in the design of medical software is particularly important due to the need to incorporate complex knowledge and actions associated with clinical work. Standard user-centered design methods include focus groups and participatory design sessions with individual stakeholders, which generally limit user involvement to a small number of individuals due to the significant time investments from designers and end users. The goal of this project was to reduce the effort for end users to participate in co-design of a software user interface by developing an interactive web-based crowdsourcing platform. In a randomized trial, we compared a new web-based crowdsourcing platform to standard participatory design sessions. We developed an interactive, modular platform that allows responsive remote customization and design feedback on a visual user interface based on user preferences. The responsive canvas is a dynamic HTML template that responds in real time to user preference selections. Upon completion, the design team can view the user's interface creations through an administrator portal and download the structured selections through a REDCap interface. We have created a software platform that allows users to customize a user interface and see the results of that customization in real time, receiving immediate feedback on the impact of their design choices. Neonatal clinicians used the new platform to successfully design and customize a neonatal handoff tool. They received no specific instruction and yet were able to use the software easily and reported high usability. VandAID, a new web-based crowdsourcing platform, can involve multiple users in user-centered design simultaneously and provides means of obtaining design feedback remotely. The software can provide design feedback at any stage in the design process, but it will be of greatest utility for specifying user requirements and evaluating iterative designs with multiple options.

Materials Design via Optimized Intramolecular Noncovalent Interactions for High-Performance Organic Semiconductors

Energy Technology Data Exchange (ETDEWEB)

Guo, Xiaojie; Liao, Qiaogan; Manley, Eric F.; Wu, Zishan; Wang, Yulun; Wang, Weida; Yang, Tingbin; Shin, Young-Eun; Cheng, Xing; Liang, Yongye; Chen, Lin X.; Baeg, Kang-Jun; Marks, Tobin J.; Guo, Xugang

2016-03-15

We report the design, synthesis, and implemention in semiconducting polymers of a novel head-to-head linkage containing the TRTOR (3-alkyl-3'-alkoxy-2,2'-bithiophene) donor subunit having a single strategically optimized, planarizing noncovalent S···O interaction. Diverse complementary thermal, optical, electrochemical, X-ray scattering, electrical, photovoltaic, and electron microscopic characterization techniques are applied to establish structure-property correlations in a TRTOR-based polymer series. In comparison to monomers having double S···O interactions, replacing one alkoxy substituent with a less electron-donating alkyl one yields TRTOR-based polymers with significantly depressed (0.2-0.3 eV) HOMOs. Furthermore, the weaker single S···O interaction and greater TRTOR steric encumberance enhances materials processability without sacrificing backbone planarity. From another perspective, TRTOR has comparable electronic properties to ring-fused 5Hdithieno[ 3,2-b:2',3'-d]pyran (DTP) subunits, but a centrosymmetric geometry which promotes a more compact and ordered structure than bulkier, axisymmetric DTP. Compared to monosubstituted TTOR (3-alkoxy-2,2'-bithiophene), alkylation at the TRTOR bithiophene 3-position enhances conjugation and polymer crystallinity with contracted π-π stacking. Grazing incidence wide-angle X-ray scattering (GIWAXS) data reveal that the greater steric hindrance and the weaker single S···O interaction are not detrimental to close packing and high crystallinity. As a proof of materials design, copolymerizing TRTOR with phthalimides yields copolymers with promising thin-film transistor mobility as high as 0.42 cm2/(V·s) and 6.3% power conversion efficiency in polymer solar cells, the highest of any phthalimide copolymers reported to date. The depressed TRTOR HOMOs imbue these polymers with substantially increased Ion/Ioff ratios and Voc’s versus analogous subunits with multiple electron donating

Materials Design via Optimized Intramolecular Noncovalent Interactions for High-Performance Organic Semiconductors

Energy Technology Data Exchange (ETDEWEB)

Guo, Xiaojie [Shenzhen Key Laboratory; Liao, Qiaogan [Shenzhen Key Laboratory; Manley, Eric F. [Department; Chemical; Wu, Zishan [Shenzhen Key Laboratory; Wang, Yulun [Shenzhen Key Laboratory; Wang, Weida [Shenzhen Key Laboratory; Yang, Tingbin [Shenzhen Key Laboratory; Shin, Young-Eun [Department; Cheng, Xing [Shenzhen Key Laboratory; Liang, Yongye [Shenzhen Key Laboratory; Chen, Lin X. [Department; Chemical; Baeg, Kang-Jun [Department; Marks, Tobin J. [Department; Guo, Xugang [Shenzhen Key Laboratory

2016-03-15

We report the design, synthesis, and implemention in semiconducting polymers of a novel head-to-head linkage containing the TRTOR (3-alkyl-3'-alkoxy-2,2'-bithiophene) donor subunit having a single strategically optimized, planarizing noncovalent S···O interaction. Diverse complementary thermal, optical, electrochemical, X-ray scattering, electrical, photovoltaic, and electron microscopic characterization techniques are applied to establish structure–property correlations in a TRTOR-based polymer series. In comparison to monomers having double S···O interactions, replacing one alkoxy substituent with a less electron-donating alkyl one yields TRTOR-based polymers with significantly depressed (0.2–0.3 eV) HOMOs. Furthermore, the weaker single S···O interaction and greater TRTOR steric encumberance enhances materials processability without sacrificing backbone planarity. From another perspective, TRTOR has comparable electronic properties to ring-fused 5H-dithieno[3,2-b:2',3'-d]pyran (DTP) subunits, but a centrosymmetric geometry which promotes a more compact and ordered structure than bulkier, axisymmetric DTP. Compared to monosubstituted TTOR (3-alkoxy-2,2'-bithiophene), alkylation at the TRTOR bithiophene 3-position enhances conjugation and polymer crystallinity with contracted π–π stacking. Grazing incidence wide-angle X-ray scattering (GIWAXS) data reveal that the greater steric hindrance and the weaker single S···O interaction are not detrimental to close packing and high crystallinity. As a proof of materials design, copolymerizing TRTOR with phthalimides yields copolymers with promising thin-film transistor mobility as high as 0.42 cm2/(V·s) and 6.3% power conversion efficiency in polymer solar cells, the highest of any phthalimide copolymers reported to date. The depressed TRTOR HOMOs imbue these polymers with substantially increased Ion/Ioff ratios and Voc’s versus analogous subunits with multiple electron

Application of Monte Carlo filtering method in regional sensitivity analysis of AASHTOWare Pavement ME design

Directory of Open Access Journals (Sweden)

Zhong Wu

2017-04-01

Full Text Available Since AASHTO released the Mechanistic-Empirical Pavement Design Guide (MEPDG for public review in 2004, many highway research agencies have performed sensitivity analyses using the prototype MEPDG design software. The information provided by the sensitivity analysis is essential for design engineers to better understand the MEPDG design models and to identify important input parameters for pavement design. In literature, different studies have been carried out based on either local or global sensitivity analysis methods, and sensitivity indices have been proposed for ranking the importance of the input parameters. In this paper, a regional sensitivity analysis method, Monte Carlo filtering (MCF, is presented. The MCF method maintains many advantages of the global sensitivity analysis, while focusing on the regional sensitivity of the MEPDG model near the design criteria rather than the entire problem domain. It is shown that the information obtained from the MCF method is more helpful and accurate in guiding design engineers in pavement design practices. To demonstrate the proposed regional sensitivity method, a typical three-layer flexible pavement structure was analyzed at input level 3. A detailed procedure to generate Monte Carlo runs using the AASHTOWare Pavement ME Design software was provided. The results in the example show that the sensitivity ranking of the input parameters in this study reasonably matches with that in a previous study under a global sensitivity analysis. Based on the analysis results, the strengths, practical issues, and applications of the MCF method were further discussed.

Designing interfaces patterns for effective interaction design

CERN Document Server

Tidwell, Jenifer

2005-01-01

This convenient resource offers advice on creating user-friendly interface designs--whether they're delivered on the Web, a CD, or a smart" devices like a cell phone. Solutions to common UI design problems are expressed as a collection of patterns--each one containing concrete examples, recommendations, and warnings. Intended for designers with basic UI design knowledge

Thermodynamics of antibody-antigen interaction revealed by mutation analysis of antibody variable regions.

Science.gov (United States)

Akiba, Hiroki; Tsumoto, Kouhei

2015-07-01

Antibodies (immunoglobulins) bind specific molecules (i.e. antigens) with high affinity and specificity. In order to understand their mechanisms of recognition, interaction analysis based on thermodynamic and kinetic parameters, as well as structure determination is crucial. In this review, we focus on mutational analysis which gives information about the role of each amino acid residue in antibody-antigen interaction. Taking anti-hen egg lysozyme antibodies and several anti-small molecule antibodies, the energetic contribution of hot-spot and non-hot-spot residues is discussed in terms of thermodynamics. Here, thermodynamics of the contribution from aromatic, charged and hydrogen bond-forming amino acids are discussed, and their different characteristics have been elucidated. The information gives fundamental understanding of the antibody-antigen interaction. Furthermore, the consequences of antibody engineering are analysed from thermodynamic viewpoints: humanization to reduce immunogenicity and rational design to improve affinity. Amino acid residues outside hot-spots in the interface play important roles in these cases, and thus thermodynamic and kinetic parameters give much information about the antigen recognition. Thermodynamic analysis of mutant antibodies thus should lead to advanced strategies to design and select antibodies with high affinity. © The Authors 2015. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.

An application of interactive computer graphics technology to the design of dispersal mechanisms

Science.gov (United States)

Richter, B. J.; Welch, B. H.

1977-01-01

Interactive computer graphics technology is combined with a general purpose mechanisms computer code to study the operational behavior of three guided bomb dispersal mechanism designs. These studies illustrate the use of computer graphics techniques to discover operational anomalies, to assess the effectiveness of design improvements, to reduce the time and cost of the modeling effort, and to provide the mechanism designer with a visual understanding of the physical operation of such systems.

Enabling through design : explorations of aesthetic interaction in therapy and care

NARCIS (Netherlands)

Marti, P.

2012-01-01

Digital products generally place demands on our cognitive abilities, and deny us the opportunity of building bodily skills (Djajadiningrat et al, 2007). We have a body, we have our senses to dialogue with the environment around us. Why does interaction design not use these skills in a more

Towards for Analyzing Alternatives of Interaction Design Based on Verbal Decision Analysis of User Experience

Directory of Open Access Journals (Sweden)

Marília Soares Mendes

2010-04-01

Full Text Available In domains (as digital TV, smart home, and tangible interfaces that represent a new paradigm of interactivity, the decision of the most appropriate interaction design solution is a challenge. HCI researchers have promoted in their works the validation of design alternative solutions with users before producing the final solution. User experience with technology is a subject that has also gained ground in these works in order to analyze the appropriate solution(s. Following this concept, a study was accomplished under the objective of finding a better interaction solution for an application of mobile TV. Three executable applications of mobile TV prototypes were built. A Verbal Decision Analysis model was applied on the investigations for the favorite characteristics in each prototype based on the user’s experience and their intentions of use. This model led a performance of a qualitative analysis which objectified the design of a new prototype.

Human Work Interaction Design for Pervasive and Smart Workplaces

DEFF Research Database (Denmark)

Campos, Pedro F.; Lopes, Arminda; Clemmensen, Torkil

2014-01-01

' experience and outputs? This workshop focuses on answering this question to support professionals, academia, national labs, and industry engaged in human work analysis and interaction design for the workplace. Conversely, tools, procedures, and professional competences for designing human......Pervasive and smart technologies have pushed workplace configuration beyond linear logic and physical boundaries. As a result, workers' experience of and access to technology is increasingly pervasive, and their agency constantly reconfigured. While this in certain areas of work is not new (e.......g., technology mediation and decision support in air traffic control), more recent developments in other domains such as healthcare (e.g., Augmented Reality in Computer Aided Surgery) have raised challenging issues for HCI researchers and practitioners. The question now is: how to improve the quality of workers...

Conversational interfaces for task-oriented spoken dialogues: design aspects influencing interaction quality

NARCIS (Netherlands)

Niculescu, A.I.

2011-01-01

This dissertation focuses on the design and evaluation of speech-based conversational interfaces for task-oriented dialogues. Conversational interfaces are software programs enabling interaction with computer devices through natural language dialogue. Even though processing conversational speech is

Conserved regions of ribonucleoprotein ribonuclease MRP are involved in interactions with its substrate.

Science.gov (United States)

Esakova, Olga; Perederina, Anna; Berezin, Igor; Krasilnikov, Andrey S

2013-08-01

Ribonuclease (RNase) MRP is a ubiquitous and essential site-specific eukaryotic endoribonuclease involved in the metabolism of a wide range of RNA molecules. RNase MRP is a ribonucleoprotein with a large catalytic RNA moiety that is closely related to the RNA component of RNase P, and multiple proteins, most of which are shared with RNase P. Here, we report the results of an ultraviolet-cross-linking analysis of interactions between a photoreactive RNase MRP substrate and the Saccharomyces cerevisiae RNase MRP holoenzyme. The results show that the substrate interacts with phylogenetically conserved RNA elements universally found in all enzymes of the RNase P/MRP family, as well as with a phylogenetically conserved RNA region that is unique to RNase MRP, and demonstrate that four RNase MRP protein components, all shared with RNase P, interact with the substrate. Implications for the structural organization of RNase MRP and the roles of its components are discussed.

KEKB B-factory design report

International Nuclear Information System (INIS)

1995-08-01

KEKB is an asymmetric electron-positron collider at 8 x 3.5 GeV which aims at providing electron-positron collision at the center of mass energy of 10.58 GeV. Its mission is to support high energy physics research programs on CP violation and other topics in B-meson decay. Its luminosity goal is 10 34 /cm 2 s. As the construction of the KEKB was approved as a five-year project by the Japanese government, it was begun formally in April, 1994. The low energy ring LER for positrons at 3.5 GeV and the high energy ring HER for electrons at 8 GeV will be built side by side in the existing TRISTAN tunnel with 3 km circumference, and the maximum use of the infrastructure of TRISTAN will be made. The KEKB has only one interaction point in the Tsukuba experimental hall, and the BELLE detector will be installed in this interaction region. The layout of the two rings is explained. In this report, the basic design, hardware systems, the construction schedule, physics requirement, machine parameters, beam-beam interaction, RF parameters, impedance and collective effects, lattice design, interaction region, RF system, magnet system, vacuum system, beam instrumentation, injection and accelerator control system are described. (K.I.)

KEKB B-factory design report

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-08-01

KEKB is an asymmetric electron-positron collider at 8 x 3.5 GeV which aims at providing electron-positron collision at the center of mass energy of 10.58 GeV. Its mission is to support high energy physics research programs on CP violation and other topics in B-meson decay. Its luminosity goal is 10{sup 34}/cm{sup 2}s. As the construction of the KEKB was approved as a five-year project by the Japanese government, it was begun formally in April, 1994. The low energy ring LER for positrons at 3.5 GeV and the high energy ring HER for electrons at 8 GeV will be built side by side in the existing TRISTAN tunnel with 3 km circumference, and the maximum use of the infrastructure of TRISTAN will be made. The KEKB has only one interaction point in the Tsukuba experimental hall, and the BELLE detector will be installed in this interaction region. The layout of the two rings is explained. In this report, the basic design, hardware systems, the construction schedule, physics requirement, machine parameters, beam-beam interaction, RF parameters, impedance and collective effects, lattice design, interaction region, RF system, magnet system, vacuum system, beam instrumentation, injection and accelerator control system are described. (K.I.).

Layout Design of Human-Machine Interaction Interface of Cabin Based on Cognitive Ergonomics and GA-ACA

OpenAIRE

Deng, Li; Wang, Guohua; Yu, Suihuai

2016-01-01

In order to consider the psychological cognitive characteristics affecting operating comfort and realize the automatic layout design, cognitive ergonomics and GA-ACA (genetic algorithm and ant colony algorithm) were introduced into the layout design of human-machine interaction interface. First, from the perspective of cognitive psychology, according to the information processing process, the cognitive model of human-machine interaction interface was established. Then, the human cognitive cha...

Motivation, Participation, and Engagement in Human Work Interaction Design Literature

DEFF Research Database (Denmark)

Barricelli, Barbara Rita; Clemmensen, Torkil; Campos, Pedro

2016-01-01

This position paper is aimed at presenting as discussion material at the CoPDA 2016 Workshop the preliminary results of a short review of the literature published by the HWID community in the last 10 years in four books. Specifically, the attention is posed on understanding the importance of moti...... of motivation, participation, and engagement in Interaction Design projects for smart and pervasive workplaces...

Design and simulation of a sub-terahertz folded-waveguide extended interaction oscillator

Science.gov (United States)

Liu, Wenxin; Zhang, Zhaochuan; Zhao, Chao; Guo, Xin; Liao, Suying

2017-06-01

In this paper, an interesting type of a two-section folded wave-guide (TSFW) slow wave structure (SWS) for the development of sub-Terahertz (sub-THz) extended interaction oscillator (EIO) is proposed. In this sub-THz device, the prebunching electron beam is produced by the TSFW SWS, which results in the enhancement of the output power. To verify this concept, the TSFW for sub-THz EIO is developed, which includes the design, simulation, and some fabrications. A small size of electron optics system (EOS), the TSFW SWS for beam-wave interactions, and the output structure are studied with simulations. Through the codes Egun and Superfish, the EOS is designed and optimized. With a help of CST studio and 3D particle-in-cell (PIC) simulation CHIPIC, the characteristics of beam-wave interaction generated by the TSFW are studied. The results of PIC simulation show that the output power is remarkably enhanced by a factor of 3, which exceeds 200 W at the frequency of 108 GHz. Based on the optimum parameters, the TSFW is manufactured with a high speed numerical mill, and the test transmission characteristic |S21| is 13 dB. At last, the output structure with a pill-box window is optimized, fabricated, integrated, and tested, and the result shows that the voltage standing-wave ratio of the window is about 2.2 at an operating frequency of 108 GHz. This design and simulation can provide an effective method to develop high power THz sources.

Collaborative design support : workshops to stimulate interaction and knowledge exchange between practitioners

NARCIS (Netherlands)

Quanjel, E.M.C.J.

2013-01-01

The focus of this research project is on the effectiveness of Collaborative Design activities of practitioners. More specifically, the research project focuses to interaction and knowledge exchange between two specific practitioners, Architects and Contractors, with a different educational

Identification of T1D susceptibility genes within the MHC region by combining protein interaction networks and SNP genotyping data

DEFF Research Database (Denmark)

Brorsson, C.; Hansen, Niclas Tue; Hansen, Kasper Lage

2009-01-01

genes. We have developed a novel method that combines single nucleotide polymorphism (SNP) genotyping data with protein-protein interaction (ppi) networks to identify disease-associated network modules enriched for proteins encoded from the MHC region. Approximately 2500 SNPs located in the 4 Mb MHC......To develop novel methods for identifying new genes that contribute to the risk of developing type 1 diabetes within the Major Histocompatibility Complex (MHC) region on chromosome 6, independently of the known linkage disequilibrium (LD) between human leucocyte antigen (HLA)-DRB1, -DQA1, -DQB1...... region were analysed in 1000 affected offspring trios generated by the Type 1 Diabetes Genetics Consortium (T1DGC). The most associated SNP in each gene was chosen and genes were mapped to ppi networks for identification of interaction partners. The association testing and resulting interacting protein...

Design Principles for Interactive Software

DEFF Research Database (Denmark)

The book addresses the crucial intersection of human-computer interaction (HCI) and software engineering by asking both what users require from interactive systems and what developers need to produce well-engineered software. Needs are expressed as...

Quality by Design approach in the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol and its impurities.

Science.gov (United States)

Jovanović, Marko; Rakić, Tijana; Tumpa, Anja; Jančić Stojanović, Biljana

2015-06-10

This study presents the development of hydrophilic interaction liquid chromatographic method for the analysis of iohexol, its endo-isomer and three impurities following Quality by Design (QbD) approach. The main objective of the method was to identify the conditions where adequate separation quality in minimal analysis duration could be achieved within a robust region that guarantees the stability of method performance. The relationship between critical process parameters (acetonitrile content in the mobile phase, pH of the water phase and ammonium acetate concentration in the water phase) and critical quality attributes is created applying design of experiments methodology. The defined mathematical models and Monte Carlo simulation are used to evaluate the risk of uncertainty in models prediction and incertitude in adjusting the process parameters and to identify the design space. The borders of the design space are experimentally verified and confirmed that the quality of the method is preserved in this region. Moreover, Plackett-Burman design is applied for experimental robustness testing and method is fully validated to verify the adequacy of selected optimal conditions: the analytical column ZIC HILIC (100 mm × 4.6 mm, 5 μm particle size); mobile phase consisted of acetonitrile-water phase (72 mM ammonium acetate, pH adjusted to 6.5 with glacial acetic acid) (86.7:13.3) v/v; column temperature 25 °C, mobile phase flow rate 1 mL min(-1), wavelength of detection 254 nm. Copyright © 2015 Elsevier B.V. All rights reserved.

The Design of an Interactive Data Retrieval System for Casual Users.

Science.gov (United States)

Radhakrishnan, T.; And Others

1982-01-01

Describes an interactive data retrieval system which was designed and implemented for casual users and which incorporates a user-friendly interface, aids to train beginners in use of the system, versatility in output, and error recovery protocols. A 14-item reference list and two figures illustrating system operation and output are included. (JL)

Remixing to Design Learning: Social Media and Peer-to-Peer Interaction

Science.gov (United States)

Casey, Gail; Wells, Muriel

2015-01-01

Social and participatory media offer opportunities to interact and share user-generated content. After some investigation and research, the authors are in their initial stages of using such media to provide a pathway for thinking about learning design in higher education. Using the concept of remixing, the authors aim to creatively blend and…

C-terminal region of the UV-B photoreceptor UVR8 initiates signaling through interaction with the COP1 protein

Science.gov (United States)

Cloix, Catherine; Kaiserli, Eirini; Heilmann, Monika; Baxter, Katherine J.; Brown, Bobby A.; O’Hara, Andrew; Smith, Brian O.; Christie, John M.; Jenkins, Gareth I.

2012-01-01

UV-B light initiates photomorphogenic responses in plants. Arabidopsis UV RESISTANCE LOCUS8 (UVR8) specifically mediates these responses by functioning as a UV-B photoreceptor. UV-B exposure converts UVR8 from a dimer to a monomer, stimulates the rapid accumulation of UVR8 in the nucleus, where it binds to chromatin, and induces interaction of UVR8 with CONSTITUTIVELY PHOTOMORPHOGENIC1 (COP1), which functions with UVR8 to control photomorphogenic UV-B responses. Although the crystal structure of UVR8 reveals the basis of photoreception, it does not show how UVR8 initiates signaling through interaction with COP1. Here we report that a region of 27 amino acids from the C terminus of UVR8 (C27) mediates the interaction with COP1. The C27 region is necessary for UVR8 function in the regulation of gene expression and hypocotyl growth suppression in Arabidopsis. However, UVR8 lacking C27 still undergoes UV-B–induced monomerization in both yeast and plant protein extracts, accumulates in the nucleus in response to UV-B, and interacts with chromatin at the UVR8-regulated ELONGATED HYPOCOTYL5 (HY5) gene. The UV-B–dependent interaction of UVR8 and COP1 is reproduced in yeast cells and we show that C27 is both necessary and sufficient for the interaction of UVR8 with the WD40 domain of COP1. Furthermore, we show that C27 interacts in yeast with the REPRESSOR OF UV-B PHOTOMORPHOGENESIS proteins, RUP1 and RUP2, which are negative regulators of UVR8 function. Hence the C27 region has a key role in UVR8 function. PMID:22988111

HyperCell : A Bio-inspired Design Framework for Real-time Interactive Architectures

NARCIS (Netherlands)

Chang, J.R.

2018-01-01

This pioneering research focuses on Biomimetic Interactive Architecture using “Computation”, “Embodiment”, and “Biology” to generate an intimate embodied convergence to propose a novel rule-based design framework for creating organic architectures composed of swarm-based intelligent components.

Control system design and analysis using the INteractive Controls Analysis (INCA) program

Science.gov (United States)

Bauer, Frank H.; Downing, John P.

1987-01-01

The INteractive Controls Analysis (INCA) program was developed at the Goddard Space Flight Center to provide a user friendly efficient environment for the design and analysis of linear control systems. Since its inception, INCA has found extensive use in the design, development, and analysis of control systems for spacecraft, instruments, robotics, and pointing systems. Moreover, the results of the analytic tools imbedded in INCA have been flight proven with at least three currently orbiting spacecraft. This paper describes the INCA program and illustrates, using a flight proven example, how the package can perform complex design analyses with relative ease.

SLC ir conceptual design

International Nuclear Information System (INIS)

Keller, L.P.