WorldWideScience

Sample records for integrated response equipment

  1. CV equipment responsibilities

    CERN Document Server

    Pirollet, B

    2008-01-01

    This document describes the limits of the responsibilities of the TS/CV for fire fighting equipment at the LHC. The various interfaces, providers and users of the water supply systems and clean water raising systems are described.

  2. Response to waste electrical and electronic equipments in China: legislation, recycling system, and advanced integrated process.

    Science.gov (United States)

    Zhou, Lei; Xu, Zhenming

    2012-05-01

    Over the past 30 years, China has been suffering from negative environmental impacts from distempered waste electrical and electronic equipments (WEEE) recycling activities. For the purpose of environmental protection and resource reusing, China made a great effort to improve WEEE recycling. This article reviews progresses of three major fields in the development of China's WEEE recycling industry: legal system, formal recycling system, and advanced integrated process. Related laws concerning electronic waste (e-waste) management and renewable resource recycling are analyzed from aspects of improvements and loopholes. The outcomes and challenges for existing formal recycling systems are also discussed. The advantage and deficiency related to advanced integrated recycling processes for typical e-wastes are evaluated respectively. Finally, in order to achieve high disposal rates of WEEE, high-quantify separation of different materials in WEEE and high added value final products produced by separated materials from WEEE, an idea of integrated WEEE recycling system is proposed to point future development of WEEE recycling industry. © 2012 American Chemical Society

  3. Aircraft Wiring Support Equipment Integration Laboratory (AWSEIL)

    Data.gov (United States)

    Federal Laboratory Consortium — Purpose:The Aircraft Wiring Support Equipment Integration Laboratory (AWSEIL) provides a variety of research, design engineering and prototype fabrication services...

  4. Generation of equipment response spectrum considering equipment-structure interaction

    International Nuclear Information System (INIS)

    Lee, Sang Hoon; Yoo, Kwang Hoon

    2005-01-01

    Floor response spectra for dynamic response of subsystem such as equipment, or piping in nuclear power plant are usually generated without considering dynamic interaction between main structure and subsystem. Since the dynamic structural response generally has the narrow-banded shapes, the resulting floor response spectra developed for various locations in the structure usually have high spectral peak amplitudes in the narrow frequency bands corresponding to the natural frequencies of the structural system. The application of such spectra for design of subsystems often leads to excessive design conservatisms, especially when the equipment frequency and structure are at resonance condition. Thus, in order to provide a rational and realistic design input for dynamic analysis and design of equipment, dynamic equipment-structure interaction (ESI) should be considered in developing equipment response spectrum which is particularly important for equipment at the resonance condition. Many analytical methods have been proposed in the past for developing equipment response spectra considering ESI. However, most of these methods have not been adapted to the practical applications because of either the complexities or the lack of rigorousness of the methods. At one hand, mass ratio among the equipment and structure was used as an important parameter to obtain equipment response spectra. Similarly, Tseng has also proposed the analytical method for developing equipment response spectra using mass ratio in the frequency domain. This method is analytically rigorous and can be easily validated. It is based on the dynamic substructuring method as applied to the dynamic soil-structure interaction (SSI) analysis, and can relatively easily be implemented for practical applications without to change the current dynamic analysis and design practice for subsystems. The equipment response spectra derived in this study are also based on Tseng's proposed method

  5. Functional integration of digital radiologic equipment

    International Nuclear Information System (INIS)

    Agnifili, A.; DiStefano, G.; Salcito, G.; Passariello, R.

    1989-01-01

    This paper reports on a pilot project for the functional integration of digital radiologic equipment. Four different systems (a digital subtraction angiography unit, a DF unit, a computer radiography prototype, and a film digitizer) were connected with a link in an Ethernet LAN.ACR-NEMA standards were used to process the images of the different units in the same way. The central computer manages the long-term optical archive and the film laser printer. Some graphic workstations are connected to the picture archiving and communications system, which allows fast retrieval and processing of the images. Patients; data are acquired through the RIS and stored together with the images

  6. Plant-wide integrated equipment monitoring and analysis system

    International Nuclear Information System (INIS)

    Morimoto, C.N.; Hunter, T.A.; Chiang, S.C.

    2004-01-01

    A nuclear power plant equipment monitoring system monitors plant equipment and reports deteriorating equipment conditions. The more advanced equipment monitoring systems can also provide information for understanding the symptoms and diagnosing the root cause of a problem. Maximizing the equipment availability and minimizing or eliminating consequential damages are the ultimate goals of equipment monitoring systems. GE Integrated Equipment Monitoring System (GEIEMS) is designed as an integrated intelligent monitoring and analysis system for plant-wide application for BWR plants. This approach reduces system maintenance efforts and equipment monitoring costs and provides information for integrated planning. This paper describes GEIEMS and how the current system is being upgraded to meet General Electric's vision for plant-wide decision support. (author)

  7. Response of equipment to aircraft impact

    International Nuclear Information System (INIS)

    Wolf, J.P.; Bucher, K.M.; Skrikerud, P.E.

    1977-01-01

    The loading case of an aircraft crashing onto certain safety-relevant buildings of a nuclear-power plant has recently become, in certain countries, as important as that of the safe-shutdown earthquake. Although its probability of occurrence is substantially smaller than that of the SSE, the analysis is justified as an aircraft can also be regarded as representative of other shock loading cases. For the purpose of design it is convenient to distinguish between the response of the actual structure and that of the equipment. The former, which consists of global stress resultants and of local effects such as spalling, scabbing, penetration and perforation of the concrete of the structure, is quite well understood and is not examined in this paper. The latter, caused by propagating shock waves, has, rather surprisingly, received little attention, although, for earthquake excitation, the analysis of equipment is routinely performed. The high accelerations experienced by the equipment are calculated and the corresponding floor-response spectra show that the airplane crash is dominant in the high-frequency range, when compared to the effect of earthquakes. As the aircraft impacts on a small area of the structure only, and the corresponding function of the load versus time exhibits a substantial content of high frequency, the modelling of the structure has to be rather detailed. Several thousand dynamic degrees of freedom in a finite-element idealization result, when analyzing e.g. a typical reactor auxiliary building, the familiar lumped-beam models used successfully for earthquake analysis can obviously not be chosen. (Auth.)

  8. Responsibility and Integrated Thinking

    OpenAIRE

    Robinson, SJ

    2014-01-01

    Integrated thinking is essentially focused in dialogue and communication. This is partly because relationships and related purpose focus on action, which itself acts as a means of integration, and partly because critical dialogue enables better, more responsive, integrated thinking and action.

  9. Integrated reliability condition monitoring and maintenance of equipment

    CERN Document Server

    Osarenren, John

    2015-01-01

    Consider a Viable and Cost-Effective Platform for the Industries of the Future (IOF) Benefit from improved safety, performance, and product deliveries to your customers. Achieve a higher rate of equipment availability, performance, product quality, and reliability. Integrated Reliability: Condition Monitoring and Maintenance of Equipment incorporates reliable engineering and mathematical modeling to help you move toward sustainable development in reliability condition monitoring and maintenance. This text introduces a cost-effective integrated reliability growth monitor, integrated reliability degradation monitor, technological inheritance coefficient sensors, and a maintenance tool that supplies real-time information for predicting and preventing potential failures of manufacturing processes and equipment. The author highlights five key elements that are essential to any improvement program: improving overall equipment and part effectiveness, quality, and reliability; improving process performance with maint...

  10. Integrated logistics management system for operation of machinery and equipment

    Directory of Open Access Journals (Sweden)

    Józef Frąś

    2014-09-01

    Full Text Available Background: The main issue in the operations of machinery and equipment, which is the subject of theoretical and empirical research is to provide high reliability and durability with qualitative post-trade services of machinery and equipment. Quality of service can be achieved through planned maintenance activities supported by computer technology. The article presents the concept of an integrated system of logistics management operation of machinery and equipment, especially special one for stationary transport equipment. At the outset, it emphasized the importance and essence of technological transport and storage systems storage in modern manufacturing enterprise. Then the objective and the method of research have been set. An essential part of deliberations in the article is the concept of integrated logistics management system operation for stationary transport equipment. Authors of this article have presented the results the implementation and operation of the system. The results are presented in a descriptive and graphic form. Methods: The purpose of this article is to present the concept of implementing an integrated logistics management system for operation of stationary transport equipment. It goes through combination of planning, event logging service, warehouse management in the field of spare parts, account and records of the cost of service activities. The paper presents an analysis and evaluation method of brainstorming a new approach to logistics management operation stationary transport equipment. Authors takes into account the specific conditions of use of transport equipment and conduct the service, which have a significant impact on the time and place of cost and service as well. It should be noted that the developed system has been implemented. It was also carried out an assessment of its functionality and efficiency as the new IT tool for logistics management operation. Results and conclusions: The paper presents a new

  11. Integrated marketing communications at solar energy equipment market

    OpenAIRE

    I.L. Litovchenko; I.A. Shkurupskaya

    2013-01-01

    The aim of the article. The article is devoted to the development of the concept of «integrated marketing communications», as well as its adaptation to a specific market of solar energy equipment. The theoretical development of foreign and domestic scholars in the field of IMC is considered. The aim of the article is to define the concept of «integrated marketing communications» and use them in the market of solar еnergy equipment in an information economy. The author's definition of the c...

  12. Infrastructure for Integration of Legacy Electrical Equipment into a Smart-Grid Using Wireless Sensor Networks.

    Science.gov (United States)

    de Araújo, Paulo Régis C; Filho, Raimir Holanda; Rodrigues, Joel J P C; Oliveira, João P C M; Braga, Stephanie A

    2018-04-24

    At present, the standardisation of electrical equipment communications is on the rise. In particular, manufacturers are releasing equipment for the smart grid endowed with communication protocols such as DNP3, IEC 61850, and MODBUS. However, there are legacy equipment operating in the electricity distribution network that cannot communicate using any of these protocols. Thus, we propose an infrastructure to allow the integration of legacy electrical equipment to smart grids by using wireless sensor networks (WSNs). In this infrastructure, each legacy electrical device is connected to a sensor node, and the sink node runs a middleware that enables the integration of this device into a smart grid based on suitable communication protocols. This middleware performs tasks such as the translation of messages between the power substation control centre (PSCC) and electrical equipment in the smart grid. Moreover, the infrastructure satisfies certain requirements for communication between the electrical equipment and the PSCC, such as enhanced security, short response time, and automatic configuration. The paper’s contributions include a solution that enables electrical companies to integrate their legacy equipment into smart-grid networks relying on any of the above mentioned communication protocols. This integration will reduce the costs related to the modernisation of power substations.

  13. Infrastructure for Integration of Legacy Electrical Equipment into a Smart-Grid Using Wireless Sensor Networks

    Directory of Open Access Journals (Sweden)

    Paulo Régis C. de Araújo

    2018-04-01

    Full Text Available At present, the standardisation of electrical equipment communications is on the rise. In particular, manufacturers are releasing equipment for the smart grid endowed with communication protocols such as DNP3, IEC 61850, and MODBUS. However, there are legacy equipment operating in the electricity distribution network that cannot communicate using any of these protocols. Thus, we propose an infrastructure to allow the integration of legacy electrical equipment to smart grids by using wireless sensor networks (WSNs. In this infrastructure, each legacy electrical device is connected to a sensor node, and the sink node runs a middleware that enables the integration of this device into a smart grid based on suitable communication protocols. This middleware performs tasks such as the translation of messages between the power substation control centre (PSCC and electrical equipment in the smart grid. Moreover, the infrastructure satisfies certain requirements for communication between the electrical equipment and the PSCC, such as enhanced security, short response time, and automatic configuration. The paper’s contributions include a solution that enables electrical companies to integrate their legacy equipment into smart-grid networks relying on any of the above mentioned communication protocols. This integration will reduce the costs related to the modernisation of power substations.

  14. Reconciliation of equipment flexibility effects on piping system dynamic response

    International Nuclear Information System (INIS)

    Geraets, L.H.

    1987-01-01

    Piping systems are connected to equipment; if the equipment cannot be considered as ''rigid'' relative to excitation frequencies, nozzle response spectra techniques, or equipment modeling techniques are used. If the equipment is considered rigid, a fixed anchor is assumed. However, occasionally after (seismic) dynamic analysis has been completed, tests or detailed equipment dynamic analyses demonstrate that the assumption of ''infinite stiff'' is questionable. This paper reviews several classes of equipment (pumps, vessels, reservoirs, heat exchangers), and the associated (piping stresses, support loads, equipment nozzle allowables). Significant divergences between design and ''as built'' results are shown (for heat exchangers in particular). The paper discusses the reconciliation process performed for a belgian PWR plant through the use of less conservative seismic damping data (Code Case N-411)

  15. Modification of evaluation response spectrum by ductility of equipment anchorage

    International Nuclear Information System (INIS)

    Choi, I. G.; Jun, Y. S.; Su, J. M.

    2003-01-01

    The failure mode of welded anchorage is assumed as brittle in the seismic capacity evaluation of nuclear power plant equipments. But the welded anchorage has some ductile capacity. This limited displacement capacity can cause the reduction of the effective frequency of high frequency equipments and the increase of the inelastic energy absorption capacity due to the nonlinear behavior. In this study, the uniform hazard spectrum for Korean nuclear power plant site was modified using the response spectrum reduction factor developed by EPRI. The spectral acceleration for various damping ratio was determined by the theoretical method based on the random vibration theory. In conclusion, the high frequency components of evaluation response spectra were greatly reduced due to the consideration of welded anchorage ductility. This reduced response spectra can be used for the development of in-structure response spectra used in the seismic capacity evaluation of high frequency equipments

  16. Timing criteria for supplemental BWR emergency response equipment

    International Nuclear Information System (INIS)

    Bickel, John H.

    2015-01-01

    The Great Tohuku Earthquake and subsequent Tsunami represented a double failure event which destroyed offsite power connections to Fukushima-Daiichi site and then destroyed on-site electrical systems needed to run decay heat removal systems. The accident could have been mitigated had there been supplemental portable battery chargers, supplemental pumps, and in-place piping connections to provide alternate decay heat removal. In response to this event in the USA, two national response centers, one in Memphis, Tennessee, and another in Phoenix, Arizona, will begin operation. They will be able to dispatch supplemental emergency response equipment to any nuclear plant in the U.S. within 24 hours. In order to define requirements for supplemental nuclear power plant emergency response equipment maintained onsite vs. in a regional support center it is necessary to confirm: (a) the earliest time such equipment might be needed depending on the specific scenario, (b) the nominal time to move the equipment from a storage location either on-site or within the region of a nuclear power plant, and (c) the time required to connect in the supplemental equipment to use it. This paper describes an evaluation process for a BWR-4 with a Mark I Containment starting with: (a) severe accident simulation to define best estimate times available for recovery based on the specific scenario, (b) identify the key supplemental response equipment needed at specific times to accomplish recovery of key safety functions, and (c) evaluate what types of equipment should be warehoused on-site vs. in regional response centers. (authors)

  17. Integrated software system for improving medical equipment management.

    Science.gov (United States)

    Bliznakov, Z; Pappous, G; Bliznakova, K; Pallikarakis, N

    2003-01-01

    The evolution of biomedical technology has led to an extraordinary use of medical devices in health care delivery. During the last decade, clinical engineering departments (CEDs) turned toward computerization and application of specific software systems for medical equipment management in order to improve their services and monitor outcomes. Recently, much emphasis has been given to patient safety. Through its Medical Device Directives, the European Union has required all member nations to use a vigilance system to prevent the reoccurrence of adverse events that could lead to injuries or death of patients or personnel as a result of equipment malfunction or improper use. The World Health Organization also has made this issue a high priority and has prepared a number of actions and recommendations. In the present workplace, a new integrated, Windows-oriented system is proposed, addressing all tasks of CEDs but also offering a global approach to their management needs, including vigilance. The system architecture is based on a star model, consisting of a central core module and peripheral units. Its development has been based on the integration of 3 software modules, each one addressing specific predefined tasks. The main features of this system include equipment acquisition and replacement management, inventory archiving and monitoring, follow up on scheduled maintenance, corrective maintenance, user training, data analysis, and reports. It also incorporates vigilance monitoring and information exchange for adverse events, together with a specific application for quality-control procedures. The system offers clinical engineers the ability to monitor and evaluate the quality and cost-effectiveness of the service provided by means of quality and cost indicators. Particular emphasis has been placed on the use of harmonized standards with regard to medical device nomenclature and classification. The system's practical applications have been demonstrated through a pilot

  18. Integrated inventory ranking system for oilfield equipment industry

    Directory of Open Access Journals (Sweden)

    Jalel Ben Hmida

    2014-01-01

    Full Text Available Purpose: This case study is motivated by the subcontracting problem in an oilfield equipment and service company where the management needs to decide which parts to manufacture in-house when the capacity is not enough to make all required parts. Currently the company is making subcontracting decisions based on management’s experience. Design/methodology/approach: Working with the management, a decision support system (DSS is developed to rank parts by integrating three inventory classification methods considering both quantitative factors such as cost and demand, and qualitative factors such as functionality, efficiency, and quality. The proposed integrated inventory ranking procedure will make use of three classification methods: ABC, FSN, and VED. Findings: An integration mechanism using weights is developed to rank the parts based on the total priority scores. The ranked list generated by the system helps management to identify about 50 critical parts to manufacture in-house. Originality/value: The integration of all three inventory classification techniques into a single system is a unique feature of this research. This is important as it provides a more inclusive, big picture view of the DSS for management’s use in making business decisions.

  19. Equipment response spectra for base-isolated shear beam structures

    International Nuclear Information System (INIS)

    Ahmadi, G.; Su, L.

    1992-01-01

    Equipment response spectra in base-isolated structure under seismic ground excitations are studied. The equipment is treated as a single-degree-of-freedom system attached to a nonuniform elastic beam structural model. Several leading base isolation systems, including the laminated rubber bearing, the resilient-friction base isolator with and without a sliding upper plate, and the EDF system are considered. Deflection and acceleration response spectra for the equipment and the shear beam structure subject to a sinusoidal and the accelerogram of the N00W component of El Centro 1940 earthquake are evaluated. Primary-secondary interaction effects are included in the analysis. Several numerical parametric studies are carried out and the effectiveness of different base isolation systems in protecting the nonstructural components is studied. It is shown that use of properly designed base isolation systems provides considerable protection for secondary systems, as well as, the structure against severe seismic loadings. (orig.)

  20. Inspector training for VIFM equipment - An integrated approach

    International Nuclear Information System (INIS)

    Truong, Q.S. Bob; Keeffe, R.; Ellacott, T.; Desson, K.; Herber, N.

    2001-01-01

    Full text: The VXI Integrated Fuel Monitor (VIFM) was developed by the Canadian Safeguards Support Program (CSSP) as a generic radiation monitor for safeguards applications. The VIFM equipment features a modular design, where a single cabinet can house several instruments such as bundle counters, core discharge monitors, Yes/No monitors, and other devices. VIFM can also be used in a stand-alone, transportable mode, with a detector connected to a single VIFM module linked to a laptop computer. VIFM equipment is currently in use at CANDU nuclear generating stations in several countries. Because each facility may have a different combination of detectors, the training program has been designed to reflect the modular nature of VIFM. Introductory material is generic and applies to any facility. More advanced material is carefully compartmentalized to allow IAEA Inspectors to concentrate their efforts in areas that concern them. Advanced material is available in a just-in-time reference format that simplifies rapid access to detailed information. A number of training resources have been developed, including multimedia and video material on CD-ROMs. This material has been designed to operate on a laptop computer, allowing inspectors to review and refresh their knowledge at any time - for example, during inspection trips. Although each of these resources is useful in its own right, the CSSP is developing an integrated approach to inspector training that combines all of these elements in a new way calculated to produce better training results than in the past. This new training approach features a two-day workshop preceded by a period of CD-ROM-based self-paced study. After the workshop, participants are able to make use of printed and CD-ROM-based reference materials for just-in-time 'refreshers'. Each step in this integrated approach to training will be described in the presentation. Briefly, the steps are as follows. A multimedia computer-based training package is made

  1. Response of equipment in nuclear power plants to airplane crash

    International Nuclear Information System (INIS)

    Schalk, M.; Woelfel, H.

    1975-01-01

    The question has been posed concerning the effect of airplane crash on the safety of the equipment (pipes, vessels, etc.) mounted on the floors and walls inside the outer structure. This equipment is set into vibration by the crash-induced shaking of the outer building; the resulting stresses may be quite appreciable. The following questions arise: a) how large are these stresses. Can they, for example, be larger than the stresses produced by earthquake loading. b) What are the significant response parameters. c) Which methods of analysis and design criteria are reasonable. To what extent is it possible to apply the techniques which have become generally accepted for earthquake loading. The paper presents a preliminary answer to these questions pending further work in this area. (orig./HP) [de

  2. Analysis of the computational methods on the equipment shock response based on ANSYS environments

    International Nuclear Information System (INIS)

    Wang Yu; Li Zhaojun

    2005-01-01

    With the developments and completions of equipment shock vibration theory, math calculation method simulation technique and other aspects, equipment shock calculation methods are gradually developing form static development to dynamic and from linearity to non-linearity. Now, the equipment shock calculation methods applied worldwide in engineering practices mostly include equivalent static force method, Dynamic Design Analysis Method (abbreviated to DDAM) and real-time simulation method. The DDAM is a method based on the modal analysis theory, which inputs the shock design spectrum as shock load and gets hold of the shock response of the integrated system by applying separate cross-modal integrating method within the frequency domain. The real-time simulation method is to carry through the computational analysis of the equipment shock response within the time domain, use the time-history curves obtained from real-time measurement or spectrum transformation as the equipment shock load and find an iterative solution of a differential equation of the system movement by using the computational procedure within the time domain. Conclusions: Using the separate DDAM and Real-time Simulation Method, this paper carried through the shock analysis of a three-dimensional frame floating raft in ANSYS environments, analyzed the result, and drew the following conclusion: Because DDAM does not calculate damping, non-linear effect and phase difference between mode responses, the result is much bigger than that of real-time simulation method. The coupling response is much complex when the mode result of 3-dimension structure is being calculated, and the coupling response of non-shock direction is also much bigger than that of real-time simulation method when DDAM is applied. Both DDAM and real-time simulation method has its good points and scope of application. The designers should select the design method that is economic and in point according to the features and anti

  3. Integration of Diagnostics into Ground Equipment Study. Volume 1

    National Research Council Canada - National Science Library

    Kumara, Soundar; Gautam, N; Hall, Dave; Purao, Sandeep; Garga, Amulya; Grimes, Barney

    2004-01-01

    ...) for Ground Equipment used by the U.S. Marine Corps. The study reviewed the sources of Autonomic Logistics data, the data requirements, the timeliness or required "pull" of such data, its transmission means...

  4. Power/response spectrum transformations in equipment qualification

    International Nuclear Information System (INIS)

    Unruh, J.F.; Kana, D.D.

    1985-01-01

    Since its introduction a few years ago the use of the power/response spectrum transformation has gained considerable interest and acceptance, and a number of new applications of the transformation have been developed in the equipment qualification area. A brief review of the power/response spectrum transformation is given with a discussion of the input/output relationships for linear systems required for elevated power spectrum generation. Frequency content of earthquakelike signals is discussed with emphasis on the resolution given by the PSD. The problem of excessive ZPA due to inconsistent spectra enveloping and mechanical nonlinearities is also discussed. The PSD/RS transformation is applied to the problems of combining various dynamic load events, developing bounding spectra, and developing damping consistent test spectra. Development of elevated component spectra corrected for base overtest and generation from in-situ measurements is reviewed

  5. Electric vehicle station equipment for grid-integrated vehicles

    Science.gov (United States)

    Kempton, Willett; Kiamilev, Fouad; McGee, Rodney; Waite, Nick

    2017-09-05

    Methods, systems, and apparatus transferring power between the grid and an electric vehicle are disclosed. The apparatus may include at least one vehicle communication port for interfacing with electric vehicle equipment (EVE) and a processor coupled to the at least one vehicle communication port to establish communication with the EVE, receive EVE attributes from the EVE, and transmit electric vehicle station equipment (EVSE) attributes to the EVE. Power may be transferred between the grid and the electric vehicle by maintaining EVSE attributes, establishing communication with the EVE, and transmitting the EVSE maintained attributes to the EVE.

  6. Response of equipment in nuclear power plants to airplane crash

    International Nuclear Information System (INIS)

    Schalk, M.; Woelfel, H.

    1976-01-01

    Nuclear power plants in Germany are to be designed against airplane crash. Two problems arise: first, the local problem of penetration as well as local destruction of the building and secondly the airplane induced vibrations of the whole building which cause loadings for secondary systems (equipment). This paper deals especially with the second problem. Floor response spectra due to airplane crash are presented for two different power plant buildings. The influence of various parameters (time history of excitation, direction and location of impact, mathematical model, soil, damping, etc.) are discussed. A comparison with the results of earthquake loading is given. Suggestions are made for developing suitable floor design spectra and using them to analyse multidegree-of-freedom systems. However, the paper gives only a partial answer to the questions arising because of some important restrictions which had to be made. Studies concerning these restrictions are still being conducted and will be presented in a separate paper. (Auth.)

  7. Seismic response and rehabilitation of critical substation equipment

    Energy Technology Data Exchange (ETDEWEB)

    Saadeghvaziri, M.A.; Allaverdi, N.H. [New Jersey Inst. of Technology, Newark, NJ (United States); Ashrafi, A. [Columbia Univ., New York, NY (United States); Ersoy, S. [Greenman-Pedersen Inc., Babylon, NY (United States)

    2004-07-01

    Substations are one of the most important components of an electrical power system. They provide protection to transmission and distribution lines and transfer power between different voltage levels. Transformers and bushings within the substation are vulnerable to earthquake ground motion. It is extremely important that electric power systems remain functional following seismic damage. This study assessed the seismic response of critical substation equipment and described advanced technologies for rehabilitation measures such as the Friction Pendulum System (FPS). It presents the results of an extensive finite element analysis on response of transformers and bushings. The objective was to determine the seismic behaviour of transformers and bushings during an earthquake and to determine the probability of different failure modes. The response of an FPS isolated transformer to different earthquakes was also examined along with FPS radii, ground motion intensity and vertical excitations. A finite element model was developed for FPS. The study showed that seismic isolation is a viable mitigation strategy, but a modest increase in slack must be provided. 15 refs., 1 tab., 12 figs.

  8. Integration of transport and handling equipment at CERN criteria to satisfy operational needs and safety aspects

    CERN Document Server

    Bertone, C; CERN. Geneva. TS Department

    2004-01-01

    Within the last 4 years TS-IC-HM (former ST-HM group) integrated about 150 transport and handling supplies including 29 cranes, 20 fork lift trucks, 60 tunnel vehicles. Most of these are standardised supplies, but very often special functionality has been implemented and the complexity of the equipment has been increased. With the Rocla cryo-dipol transporters even prototype equipment was integrated that had been specially designed for CERN. This paper discusses the differences regarding the actions that have to be performed when the different kind of equipment have to be integrated.

  9. Composition and fundamental requirements of nuclear emergency response monitoring equipment

    International Nuclear Information System (INIS)

    Lai Yongfang; Huang Weiqi; Wang Yonghong

    2009-01-01

    Nuclear emergency monitoring equipment is concrete foundation for accomplishing radiation monitoring in nuclear or radiation accidents. Based on technical report: Generic procedures for monitoring in a nuclear or radiological emergency published by IAEA in 1999, this paper presents the main task and composition of nuclear emergency monitoring briefly, and then the basic equipment and trends of nuclear emergency monitoring equipment is put forward in detail, which is useful to construction and reinforcement of our nuclear emergency monitoring. (authors)

  10. Electric vehicle equipment for grid-integrated vehicles

    Science.gov (United States)

    Kempton, Willett

    2013-08-13

    Methods, systems, and apparatus for interfacing an electric vehicle with an electric power grid are disclosed. An exemplary apparatus may include a station communication port for interfacing with electric vehicle station equipment (EVSE), a vehicle communication port for interfacing with a vehicle management system (VMS), and a processor coupled to the station communication port and the vehicle communication port to establish communication with the EVSE via the station communication port, receive EVSE attributes from the EVSE, and issue commands to the VMS to manage power flow between the electric vehicle and the EVSE based on the EVSE attributes. An electric vehicle may interface with the grid by establishing communication with the EVSE, receiving the EVSE attributes, and managing power flow between the EVE and the grid based on the EVSE attributes.

  11. Research on Integrated Analysis Method for Equipment and Tactics Based on Intervention Strategy Discussion

    Institute of Scientific and Technical Information of China (English)

    陈超; 张迎新; 毛赤龙

    2012-01-01

    As the increase of the complexity of the information warfare,its intervention strategy needs to be designed in an integrated environment.However,the current research always breaks the internal relation between equipment and tactics,and it is difficult to meet the requirements of their integrated analysis.In this paper,the research status quo of the integrated analysis about equipment and tactics is discussed first,some shortages of the current methods are summarized then,and an evolvement mechanism of the integrated analysis for equipment and tactics is given finally.Based on these,a framework of integrated analysis is proposed.This method's effectiveness is validated by an example.

  12. Catalog of physical protection equipment. Book 3: Volume VI. Automated response components

    International Nuclear Information System (INIS)

    Haberman, W.

    1977-06-01

    The Catalog of Physical Protection Equipment presents information on currently available physical protection equipment that could be employed to safeguard special nuclear materials. The primary source of information was the responses of manufacturers and vendors to requests for literature and data. All equipment listed in the Catalog has been screened in accordance with the following general criteria, and only items meeting one or more of these criteria have been included: (1) equipment is commercially available off-the-shelf; (2) equipment is currently in use at commercial nuclear facilities licensed or to be licensed by NRC; (3) equipment is applicable for use at nuclear facilities licensed or to be licensed by NRC; (4) equipment can operate in the environmental conditions present at nuclear facilities; and (5) equipment is not designed solely or primarily for residential use. The final report describes the methodology and rationale used to create the Catalog of Physical Protection Equipment

  13. Skills of Asn inspectors responsible for inspecting pressurised equipment

    International Nuclear Information System (INIS)

    Colonna, F.

    2010-01-01

    ASN relies on the unique competencies of its staff to assure that it can complete its mission of maintaining public health and safety. Since 1975, personnel at ASN Nuclear Pressure Equipment Department have played a major role in the oversight of pressure boundary equipment by verifying that equipment is manufactured in compliance with regulatory requirements. This has called for highly competent individuals trained in a variety of technical and regulatory backgrounds. ASN is meeting the challenge of keeping its staff trained and prepared to continue its oversight of nuclear boilers. This has included ensuring that its organization is welt suited to meet the demands, and relying on third-party experts when necessary. With the implementation of the 2006 transparency law, ASN has taken necessary steps to ensure that it will maintain its high level of expertise going forward. (author)

  14. Study on Earthquake Response of High Voltage Electrical Equipment Coupling System with Flexible Busbar

    Science.gov (United States)

    Liu, Chuncheng; Qu, Da; Wang, Chongyang; Lv, Chunlei; Li, Guoqiang

    2017-12-01

    With the rapid development of technology and society, all walks of life in China are becoming more and more dependent on power systems. When earthquake occurs, the electrical equipment of substation is prone to damage because of its own structural features, top-heavy, and brittleness of main body. At the same time, due to the complex coupling of the soft electrical connection of substation electrical equipment, the negative impact can not be estimated. In this paper, the finite element model of the coupling system of the single unit of high voltage electrical equipment with the connecting soft bus is established and the seismic response is analysed. The results showed that there is a significant difference between the simple analysis for the seismic response of electrical equipment monomer and the analytical results of electrical equipment systems, and the impact on different electrical equipment is different. It lays a foundation for the future development of seismic performance analysis of extra high voltage electrical equipment.

  15. Boosting program integrity and effectiveness of the cognitive behavioral program EQUIP for incarcerated youth in The Netherlands

    NARCIS (Netherlands)

    Helmond, P.; Overbeek, G.; Brugman, D.

    2014-01-01

    This study examined whether a "program integrity booster" could improve the low to moderate program integrity and effectiveness of the EQUIP program for incarcerated youth as practiced in The Netherlands. Program integrity was assessed in EQUIP groups before and after the booster. Youth residing in

  16. Improving electrical equipment and control systems for shield integrated mining systems

    Energy Technology Data Exchange (ETDEWEB)

    Rabinovich, Z.M.; Starikov, B.Ya.; Kibrik, I.S.

    1984-06-01

    The design and operation are discussed for electrical equipment and control systems for the 1AShchM, the ANShch and the 2ANShch shield integrated face systems consisting of shield supports, coal plow and chain conveyor. The shield system is used for mining inclined and steep coal seams endangered by coal dust explosions, methane or rock bursts. Control and electrical system for 3 types of shield face mining systems is similar. It cuts energy supply when methane content at working faces exceeds the maximum permissible level, controls haulage rate and cutting rate of a coal plow, controls operation of shield supports (using the Sirena system), controls dust suppression system and its water consumption. The system is also equipped with communications equipment. Tests of the control and electrical system for the integrated shield system carried out in the im. Gagarin mine in the Ukraine are described. The VAUS III control system developed by Dongiprouglemash was tested.

  17. An integrated approach to calculate life cycle costs of arms and military equipment

    Directory of Open Access Journals (Sweden)

    Vlada S. Sokolović

    2013-12-01

    is only a few percent and all other expenses are related to support costs. All presented elements are necessary to be analyzed through the existing organization of the military and the logistic support system, because deviations or adjustments to specific operating conditions can bring significant cost saving as well. Due to the multi-disciplinary and multi-criteria character of the process of equipping the military with AME, it is necessary to form project teams that will adequately manage the process. When the equipping is of strategic importance for the country, it is necessary that the Government and relevant ministries  take an adequate role in the process. An integrated approach to the budget and the reduction of AME life cycle costs should follow the general trends in the reform of public (state sector such as: cost and efficiency optimization, team approach to solving complex problems, greater transparency, shorter response time, introduction of a labor-incentive system, reducing administration, public-private partnerships and multinational projects. The aim is to provide a better solution, product or service or a higher level of satisfaction of the public (state interests with lower consumption of resources. In the defense sector, this means sustainable and smart defense and multinational approach in the implementation of costly projects. In order to optimize the AME life cycle costs, it is necessary, at all levels of study and training of personnel, to study certain features of integrated logistic support, to apply proper concepts and approaches and to predict and monitor organizational and technological changes in the defense system. 

  18. Generate floor response spectra, Part 2: Response spectra for equipment-structure resonance

    International Nuclear Information System (INIS)

    Li, Bo; Jiang, Wei; Xie, Wei-Chau; Pandey, Mahesh D.

    2015-01-01

    Highlights: • The concept of tRS is proposed to deal with tuning of equipment and structures. • Established statistical approaches for estimating tRS corresponding to given GRS. • Derived a new modal combination rule from the theory of random vibration. • Developed efficient and accurate direct method for generating floor response spectra. - Abstract: When generating floor response spectra (FRS) using the direct spectra-to-spectra method developed in the companion paper, probability distribution of t-response spectrum (tRS), which deals with equipment-structure resonance or tuning, corresponding to a specified ground response spectrum (GRS) is required. In this paper, simulation results using a large number of horizontal and vertical ground motions are employed to establish statistical relationships between tRS and GRS. It is observed that the influence of site conditions on horizontal statistical relationships is negligible, whereas the effect of site conditions on vertical statistical relationships cannot be ignored. Considering the influence of site conditions, horizontal statistical relationship suitable for all site conditions and vertical statistical relationships suitable for hard sites and soft sites, respectively, are established. The horizontal and vertical statistical relationships are suitable to estimate tRS for design spectra in USNRC R.G. 1.60 and NUREG/CR-0098, Uniform Hazard Spectra (UHS) in Western North America (WNA), or any GRS falling inside the valid coverage of the statistical relationship. For UHS with significant high frequency spectral accelerations, such as UHS in Central and Eastern North America (CENA), an amplification ratio method is proposed to estimate tRS. Numerical examples demonstrate that the statistical relationships and the amplification ratio method are acceptable to estimate tRS for given GRS and to generate FRS using the direct method in different practical situations.

  19. Generate floor response spectra, Part 2: Response spectra for equipment-structure resonance

    Energy Technology Data Exchange (ETDEWEB)

    Li, Bo, E-mail: b68li@uwaterloo.ca; Jiang, Wei, E-mail: w46jiang@uwaterloo.ca; Xie, Wei-Chau, E-mail: xie@uwaterloo.ca; Pandey, Mahesh D., E-mail: mdpandey@uwaterloo.ca

    2015-11-15

    Highlights: • The concept of tRS is proposed to deal with tuning of equipment and structures. • Established statistical approaches for estimating tRS corresponding to given GRS. • Derived a new modal combination rule from the theory of random vibration. • Developed efficient and accurate direct method for generating floor response spectra. - Abstract: When generating floor response spectra (FRS) using the direct spectra-to-spectra method developed in the companion paper, probability distribution of t-response spectrum (tRS), which deals with equipment-structure resonance or tuning, corresponding to a specified ground response spectrum (GRS) is required. In this paper, simulation results using a large number of horizontal and vertical ground motions are employed to establish statistical relationships between tRS and GRS. It is observed that the influence of site conditions on horizontal statistical relationships is negligible, whereas the effect of site conditions on vertical statistical relationships cannot be ignored. Considering the influence of site conditions, horizontal statistical relationship suitable for all site conditions and vertical statistical relationships suitable for hard sites and soft sites, respectively, are established. The horizontal and vertical statistical relationships are suitable to estimate tRS for design spectra in USNRC R.G. 1.60 and NUREG/CR-0098, Uniform Hazard Spectra (UHS) in Western North America (WNA), or any GRS falling inside the valid coverage of the statistical relationship. For UHS with significant high frequency spectral accelerations, such as UHS in Central and Eastern North America (CENA), an amplification ratio method is proposed to estimate tRS. Numerical examples demonstrate that the statistical relationships and the amplification ratio method are acceptable to estimate tRS for given GRS and to generate FRS using the direct method in different practical situations.

  20. Emergency response exercise of laboratories equipped with gamma spectrometry

    International Nuclear Information System (INIS)

    Mala, H.; Jezkova, T.; Rulik, P.; Beckova, V. et al.

    2014-01-01

    Seven laboratories equipped with semiconductor gamma spectrometry (HPGe detectors) are currently included in the Radiation Monitoring Network (RMN) in the Czech Republic. These laboratories have more than 30 spectrometric chains and approximately 20 'experts' and 70 'users' who would guarantee measurements during the radiological emergency (RE). The emergency exercise was carried out in 5 of them in 2014 (in 4 of them also in 2013). The aim was to test repeatedly their capacity in existing technical facilities and with current staff in the event of a RE and identify problems (bottlenecks) in the whole process from receipt of samples to entering the results into the central database of RMN. Duration of the exercise was 12 hours, due to the shortage of staff; work in one 12-hour shift is presumed during a RE, which the laboratories should be able to provide for 14 days. These exercise samples covered a wide range of commodities that would probably come to the laboratories during the RE (aerosol filters, sorbents for sorption of gaseous forms of iodine, fallout, surface and drinking waters, food chain components and soils). Some of the samples were previously spiked with 85 Sr, 88 Y and 40 K (in the exercise these nuclides represented actual contamination that would occur in RE); liquid samples were spiked with 85 Sr and 88 Y and bulk materials with 40 K.During the exercise almost 800 samples were analysed; in addition, the automatic gamma counter (GA) in Prague laboratory measured other 90 samples automatically during the night (samples were prepared during the day-shift). On the basis of the results the total measuring capacity of the laboratories of RMN CR was estimated at about 1300 samples per day. (authors)

  1. Emergency response exercise of laboratories equipped with gammaspectrometry

    International Nuclear Information System (INIS)

    Mala, H.; Jezkova, T.; Rulik, P.; Beckova, V.

    2014-01-01

    Seven laboratories equipped with semiconductor gamma spectrometry (HPGe detectors) are currently included in the Radiation Monitoring Network (RMN) in the Czech Republic. These laboratories have more than 30 spectrometric chains and approximately 20 'experts' and 70 'users' who would guarantee measurements during the radiological emergency (RE). The emergency exercise was carried out in 5 of them in 2014 (in 4 of them also in 2013). The aim was to test repeatedly their capacity in existing technical facilities and with current staff in the event of a RE and identify problems (bottlenecks) in the whole process from receipt of samples to entering the results into the central database of RMN. Duration of the exercise was 12 hours, due to the shortage of staff; work in one 12-hour shift is presumed during a RE, which the laboratories should be able to provide for 14 days. These exercise samples covered a wide range of commodities that would probably come to the laboratories during the RE (aerosol filters, sorbents for sorption of gaseous forms of iodine, fallout, surface and drinking waters, food chain components and soils). Some of the samples were previously spiked with 85 Sr, 88 Y and 40 K (in the exercise these nuclides represented actual contamination that would occur in RE); liquid samples were spiked with 85 Sr and 88 Y and bulk materials with 40 K.During the exercise almost 800 samples were analysed; in addition, the automatic gamma counter (GA) in Prague laboratory measured other 90 samples automatically during the night (samples were prepared during the day-shift). On the basis of the results the total measuring capacity of the laboratories of RMN CR was estimated at about 1300 samples per day. (authors)

  2. Risk assessment of the upstream petroleum industry's oil spill response equipment capability in western Canada

    International Nuclear Information System (INIS)

    Wotherspoon, P.; Brown, L.; Sawyer, M.

    1993-01-01

    A key component in the development of an effective onshore oil spill response capability is the type, condition, and geographical placement of oil spill equipment. When spill response equipment is first being purchased for a particular operating area, a brief analysis should be conducted to ensure that the equipment would provide an adequate response capability for that area. This response capability may change over time with variations in oil field production capabilities, pipelines and markets, company ownerships, manpower availability, and other logistical changes. Equipment may also become inoperable or redundant. These problems may be effectively addressed if one operator or spill cooperative actively reviews their spill response capabilities on a regular (annual) basis. However, when multiple operators and cooperatives exist over an extensive geographical area, the responsibility for regularly review of the capabilities of spill equipment may become lost in the organizational structure and in other responsibilities. In addition, the responsibility to conduct a multiarea review of the surrounding area may never be identified

  3. The Bosnian Train and Equip Program: A Lesson in Interagency Integration of Hard and Soft Power

    Science.gov (United States)

    2014-03-01

    even before Bos- nia officially declared independence. Most of the weaponry and commanders from the former Yugoslav People’s Army in Bosnia, which was...ability, and disposition.” 505 It covers characteristics that research indicates affect team performance including attitudinal, de- mographic, and...The Train and Equip Program reduced foreign influence in the Federation, which helped remove impediments to reconciliation and integration in Bos- nia

  4. INTEGRATED MANAGEMENT SYSTEM FOR A SOCIETY FROM INDUSTRY OF MACHINERY AND EQUIPMENT

    Directory of Open Access Journals (Sweden)

    Constanţa RĂDULESCU

    2014-05-01

    Full Text Available In this paper shows the importance that it has SMI in a society of the industry of machinery and equipment. An integrated management system is the mode to design, implement and certify two or more management systems: Quality - Environment, Quality -Environment - Safety and Occupational Health. By implementing the system, the society themselves hires in the development and continuous improvement of the system in accordance with the ones three standards and with objective of activity of the society. Also, in the paper themselves presents the advantages and disadvantages of implementing this integrated system.

  5. Safeguards equipment of the future: Integrated monitoring systems and remote monitoring

    International Nuclear Information System (INIS)

    Sonnier, C.S.; Johnson, C.S.

    1994-01-01

    From the beginning, equipment to support IAEA Safeguards could be characterized as that which is used to measure nuclear material, Destructive Assay (DA) and Non Destructive Assay (NDA), and that which is used to provide continuity of knowledge between inspection intervals, Containment ampersand Surveillance (C/S). C/S equipment has often been thought of as Cameras and Seals, with a limited number of monitors being employed as they became available. In recent years, technology has advanced at an extremely rapid rate, and continues to do so. The traditional film cameras are being replaced by video equipment, and fiber optic and electronic seals have come into rather widespread use. Perhaps the most interesting aspect of this evolution, and that which indicates the wave of the future without much question, is the integration of video surveillance and electronic seals with a variety of monitors. This is demonstrated by safeguards systems which are installed in several nuclear facilities in France, Germany, Japan, the UK, the USA, and elsewhere. The terminology of Integrated Monitoring Systems (IMS) has emerged, with the employment of network technology capable of interconnecting all desired elements in a very flexible manner. Also, the technology for transmission of a wide variety of information to off-site locations, termed Remote Monitoring, is in widespread industrial use, requiring very little adaptation for safeguards use. This paper examines the future of the Integrated Monitoring Systems and Remote Monitoring in International Safeguards, including technical and other related factors

  6. Emergency response exercise of laboratories equipped with gamma spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Mala, Helena; Rulik, Petr; Jezkova, Tereza; Beckova, Vera [National Radiation Protection Institute (SURO), 140 00 Praha 28 (Czech Republic)

    2014-07-01

    At present 7 laboratories equipped with semiconductor gamma spectrometry (HPGe detectors) are included in the Radiation Monitoring Network (RMN) in the Czech Republic. These laboratories have 31 spectrometric chains and approximately 20 'experts' and 70 'users' who would guarantee measurements during a radiological emergency (RE). The stress exercise (a load test) was carried out in 4 of them. The aim was to test their measuring capacity in existing technical facilities and staff in the event of a RE and identify problems (bottlenecks) in the whole process from receipt of samples to entering the results into the central database of RMN. Duration of the exercise was 8 to 14 hours. Due to lack of staff, work in one 12-hour shift during a RE is presumed, which the laboratories should be able to provide for 14 days. Exercise samples covered a wide range of commodities that would probably come to the laboratories during RE (aerosol filters, adsorbed gaseous forms of iodine, fallout, surface and drinking waters, food chain components and soils). Some of the samples were previously spiked with {sup 85}Sr, {sup 88}Y and {sup 40}K (these nuclides represented actual nuclides that would occur in RE); soil samples contained higher values of {sup 137}Cs activity originating from the Chernobyl accident. Almost 40 employees took part in the exercise and measurements were carried out at 18 spectrometric chains. An automatic gamma counter which allows automatic operation of two HPGe detectors including the analysis of the spectra with a storage for up to 180 sample containers was operating in one of the laboratories involved in the exercise. The procedures in individual laboratories varied slightly depending on the staff and laboratory space available. During the exercise about 700 samples were evaluated; in addition, gamma-automat measured other 80 samples in the 'night shift'. 700 samples, this means 40 samples per a spectrometric chain or, from

  7. Suitability of Strain Gage Sensors for Integration into Smart Sport Equipment: A Golf Club Example.

    Science.gov (United States)

    Umek, Anton; Zhang, Yuan; Tomažič, Sašo; Kos, Anton

    2017-04-21

    Wearable devices and smart sport equipment are being increasingly used in amateur and professional sports. Smart sport equipment employs various sensors for detecting its state and actions. The correct choice of the most appropriate sensor(s) is of paramount importance for efficient and successful operation of sport equipment. When integrated into the sport equipment, ideal sensors are unobstructive, and do not change the functionality of the equipment. The article focuses on experiments for identification and selection of sensors that are suitable for the integration into a golf club with the final goal of their use in real time biofeedback applications. We tested two orthogonally affixed strain gage (SG) sensors, a 3-axis accelerometer, and a 3-axis gyroscope. The strain gage sensors are calibrated and validated in the laboratory environment by a highly accurate Qualisys Track Manager (QTM) optical tracking system. Field test results show that different types of golf swing and improper movement in early phases of golf swing can be detected with strain gage sensors attached to the shaft of the golf club. Thus they are suitable for biofeedback applications to help golfers to learn repetitive golf swings. It is suggested that the use of strain gage sensors can improve the golf swing technical error detection accuracy and that strain gage sensors alone are enough for basic golf swing analysis. Our final goal is to be able to acquire and analyze as many parameters of a smart golf club in real time during the entire duration of the swing. This would give us the ability to design mobile and cloud biofeedback applications with terminal or concurrent feedback that will enable us to speed-up motor skill learning in golf.

  8. Demand Response and Energy Storage Integration Study

    Energy Technology Data Exchange (ETDEWEB)

    Ma, Ookie; Cheung, Kerry; Olsen, Daniel J.; Matson, Nance; Sohn, Michael D.; Rose, Cody M.; Dudley, Junqiao Han; Goli, Sasank; Kiliccote, Sila; Cappers, Peter; MacDonald, Jason; Denholm, Paul; Hummon, Marissa; Jorgenson, Jennie; Palchak, David; Starke, Michael; Alkadi, Nasr; Bhatnagar, Dhruv; Currier, Aileen; Hernandez, Jaci; Kirby, Brendan; O' Malley, Mark

    2016-03-01

    Demand response and energy storage resources present potentially important sources of bulk power system services that can aid in integrating variable renewable generation. While renewable integration studies have evaluated many of the challenges associated with deploying large amounts of variable wind and solar generation technologies, integration analyses have not yet fully incorporated demand response and energy storage resources. This report represents an initial effort in analyzing the potential integration value of demand response and energy storage, focusing on the western United States. It evaluates two major aspects of increased deployment of demand response and energy storage: (1) Their operational value in providing bulk power system services and (2) Market and regulatory issues, including potential barriers to deployment.

  9. Integrating HIV care and treatment into primary healthcare: Are clinics equipped?

    Directory of Open Access Journals (Sweden)

    Talitha Crowley

    2014-01-01

    Full Text Available Background: The demand for HIV care and treatment services is increasing rapidly and strategies to sustain long-term care should be employed. The decentralisation and integration of HIV care and treatment services into primary healthcare (PHC is vitally important in order to ensure optimal access to life-saving antiretroviral therapy and ongoing chronic care. Conversely, the PHC system is fraught with the current burden of disease. Setting: The study was conducted in PHC clinics in the uMgungundlovu district, Kwa-Zulu Natal.Aim: The objectives of the study were to assess whether PHC clinics were equipped to deliver integrated HIV services and to evaluate the availability of resources as well as support systems for HIV care and treatment in PHC clinics.Methods: A quantitative, cross-sectional descriptive study was undertaken in 20 randomly-selected, eligible clinics in the uMgungundlovu district, KwaZulu-Natal, South Africa. An evaluation instrument was completed through observations and review of the clinic data records. Criteria were based on the World Health Organization’s guide to indicators for antiretroviral programmes as well as South African HIV standards for PHC facilities.Results: None of the clinics were equipped adequately. Clinics with a higher patient load had poorer scores, whilst clinics providing antiretroviral therapy were better equipped in terms of human resources and infrastructure.Conclusion: HIV services are an essential part of primary healthcare and clinics need to be equipped adequately in order to render this service. It is unlikely that the over-burdened health system would be able to cope with an increased number of patients on antiretroviral therapy in the long term, whilst maintaining quality of services, without support being given to PHC clinics.

  10. Integrating HIV care and treatment into primary healthcare: Are clinics equipped?

    Directory of Open Access Journals (Sweden)

    Talitha Crowley

    2014-08-01

    Full Text Available Background: The demand for HIV care and treatment services is increasing rapidly and strategies to sustain long-term care should be employed. The decentralisation and integration of HIV care and treatment services into primary healthcare (PHC is vitally important in order to ensure optimal access to life-saving antiretroviral therapy and ongoing chronic care. Conversely, the PHC system is fraught with the current burden of disease. Setting: The study was conducted in PHC clinics in the uMgungundlovu district, Kwa-Zulu Natal. Aim: The objectives of the study were to assess whether PHC clinics were equipped to deliver integrated HIV services and to evaluate the availability of resources as well as support systems for HIV care and treatment in PHC clinics. Methods: A quantitative, cross-sectional descriptive study was undertaken in 20 randomly-selected, eligible clinics in the uMgungundlovu district, KwaZulu-Natal, South Africa. An evaluation instrument was completed through observations and review of the clinic data records. Criteria were based on the World Health Organization’s guide to indicators for antiretroviral programmes as well as South African HIV standards for PHC facilities. Results: None of the clinics were equipped adequately. Clinics with a higher patient load had poorer scores, whilst clinics providing antiretroviral therapy were better equipped in terms of human resources and infrastructure. Conclusion: HIV services are an essential part of primary healthcare and clinics need to be equipped adequately in order to render this service. It is unlikely that the over-burdened health system would be able to cope with an increased number of patients on antiretroviral therapy in the long term, whilst maintaining quality of services, without support being given to PHC clinics.

  11. Integrated Instrumentation and Sensor Systems Enabling Condition-Based Maintenance of Aerospace Equipment

    Directory of Open Access Journals (Sweden)

    Richard C. Millar

    2012-01-01

    Full Text Available The objective of the work reported herein was to use a systems engineering approach to guide development of integrated instrumentation/sensor systems (IISS incorporating communications, interconnections, and signal acquisition. These require enhanced suitability and effectiveness for diagnostics and health management of aerospace equipment governed by the principles of Condition-based maintenance (CBM. It is concluded that the systems engineering approach to IISS definition provided clear benefits in identifying overall system requirements and an architectural framework for categorizing and evaluating alternative architectures, relative to a bottom up focus on sensor technology blind to system level user needs. CBM IISS imperatives identified include factors such as tolerance of the bulk of aerospace equipment operational environments, low intrusiveness, rapid reconfiguration, and affordable life cycle costs. The functional features identified include interrogation of the variety of sensor types and interfaces common in aerospace equipment applications over multiplexed communication media with flexibility to allow rapid system reconfiguration to adapt to evolving sensor needs. This implies standardized interfaces at the sensor location (preferably to open standards, reduced wire/connector pin count in harnesses (or their elimination through use of wireless communications.

  12. Multisensory integration produces an initial response enhancement

    Directory of Open Access Journals (Sweden)

    Benjamin A Rowland

    2007-11-01

    Full Text Available The brain has evolved the ability to integrate information across the senses in order to improve the detection and disambiguation of biologically significant events. This multisensory synthesis of information leads to faster (and more accurate behavioral responses, yet the underlying neural mechanisms by which these responses are speeded are as yet unclear. The aim of these experiments was to evaluate the temporal properties of multisensory enhancement in the physiological responses of neuron in the superior colliculus (SC. Of specific interest was the temporal evolution of their responses to individual modality-specific stimuli as well as to cross-modal combinations of these stimuli. The results demonstrate that cross-modal stimuli typically elicit faster, more robust, and more reliable physiological responses than do their modality-specific component stimuli. Response measures sensitive to the time domain showed that these multisensory responses were enhanced from their very onset, and that the acceleration of the enhancement was greatest within the first 40 ms (or 50% of the response. The latter half of the multisensory response was typically only as robust and informative as predicted by a linear combination of the unisensory component responses. These results may reveal some of the key physiological changes underlying many of the SC-mediated behavioral benefits of multisensory integration.

  13. Instantaneous response spectrum in seismic testing of nuclear power plant equipment

    International Nuclear Information System (INIS)

    Morrone, A.

    1977-01-01

    Seismic response spectra, as used in seismic analyses, give the maximum responses of single degree of freedom oscillators without consideration of the different time in the seismic time history at which each of the maximum responses occur. For response spectrum seismic analysis, the use of time-independent maximum responses is appropriate. The time dependece is considered in a statistical manner, for multi-degree of freedom systems, usually by combining the modal effects by the square root of the sum of the squares. For seismic testing of electrical equipment. IEEE Std. 344-1975 makes use of the response spectrum to define the input motion of the shake table. One of the basic requirements is that the test response spectrum (TRS) that is, the response spectrum produced by the shake table motion, should envelop the required response spectrum (RRS) calculated from the building analysis at the support point of the equipment being tested. This paper presents the concept of instantaneous response spectrum (IRS) as the response of single degree of freedom oscillators at a particular time. It demonstrates that a shake table random motion whose standard TRS envelops the RRS does not necessarily satisfy the enveloping requirement instantaneously. (Auth.)

  14. Integrated simulation of emergency response in disasters

    International Nuclear Information System (INIS)

    Kanno, Taro; Furuta, Kazuo

    2005-01-01

    An integrated simulation system of emergency response in disasters is under development that can consider various factors of disasters, such as disaster phenomena, activities of response organizations, resident behavior, and their environment. The aim of this system is to provide support for design and assessment of disaster management systems. This paper introduces the conceptual design of the entire system and presents simulators of organizational behavior in nuclear and earthquake disasters. (author)

  15. Study concerning the power plant control and safety equipment by integrated distributed systems

    International Nuclear Information System (INIS)

    Optea, I.; Oprea, M.; Stanescu, P.

    1995-01-01

    The paper deals with the trends existing in the field of nuclear control and safety equipment and systems, proposing a high-efficiency integrated system. In order to enhance the safety of the plant and reliability of the structure system and components, we present a concept based on the latest computer technology with an open, distributed system, connected by a local area network with high redundancy. A modern conception for the control and safety system is to integrate all the information related to the reactor protection, active engineered safeguard and auxiliary systems parameters, offering a fast flow of information between all the agencies concerned so that situations can be quickly assessed. The integrated distributed control is based on a high performance operating system for realtime applications, flexible enough for transparent networking and modular for demanding configurations. The general design considerations for nuclear reactors instrumentation reliability and testing methods for real-time functions under dynamic regime are presented. Taking into account the fast progress in information technology, we consider the replacement of the old instrumentation of Cernavoda-1 NPP by a modern integrated system as an economical and efficient solution for the next units. (Author) 20 Refs

  16. Integration of radiation monitoring for nuclear emergency response teams

    Energy Technology Data Exchange (ETDEWEB)

    Olsen, J T; Thompson, N Y [Royal Military Coll. of Canada, Kingston, ON (Canada)

    1994-12-31

    The Canadian Forces have established Nuclear Emergency Response Teams to cope with potential radiation accidents. Previously, only gamma and high-energy beta radiation could be detected. Recently, new radiation sampling, detecting, and analytical equipment has been bought, including air samplers, beta counters, high-purity germanium gamma detectors, and multi-channel analyzers together with Gamma Vision Software to analyze gamma spectra. The purpose of the present study is to propose a way to use the new equipment, to analyze the results from the gamma and beta detectors, and to integrate the results into a format for decision making. Integration is achieved through the creation of a computer program, Radiation Integration Program (RIP). This program analyzes gross beta counts, and uses them to estimate danger to the thyroid. As well the results from Gamma Vision are converted from Bq to dose rate for several parts of the body. Overall gamma results affecting the thyroid are compared to the beta results to verify the initial estimations.

  17. Technical Report on Preliminary Methodology for Enhancing Risk Monitors with Integrated Equipment Condition Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, Pradeep; Coles, Garill A.; Coble, Jamie B.; Hirt, Evelyn H.

    2013-09-17

    Small modular reactors (SMRs) generally include reactors with electric output of ~350 MWe or less (this cutoff varies somewhat but is substantially less than full-size plant output of 700 MWe or more). Advanced SMRs (AdvSMRs) refer to a specific class of SMRs and are based on modularization of advanced reactor concepts. AdvSMRs may provide a longer-term alternative to traditional light-water reactors (LWRs) and SMRs based on integral pressurized water reactor concepts currently being considered. Enhancing affordability of AdvSMRs will be critical to ensuring wider deployment. AdvSMRs suffer from loss of economies of scale inherent in small reactors when compared to large (~greater than 600 MWe output) reactors. Some of this loss can be recovered through reduced capital costs through smaller size, fewer components, modular fabrication processes, and the opportunity for modular construction. However, the controllable day-to-day costs of AdvSMRs will be dominated by operation and maintenance (O&M) costs. Technologies that help characterize real-time risk are important for controlling O&M costs. Risk monitors are used in current nuclear power plants to provide a point-in-time estimate of the system risk given the current plant configuration (e.g., equipment availability, operational regime, and environmental conditions). However, current risk monitors are unable to support the capability requirements listed above as they do not take into account plant-specific normal, abnormal, and deteriorating states of active components and systems. This report documents technology developments that are a step towards enhancing risk monitors that, if integrated with supervisory plant control systems, can provide the capability requirements listed and meet the goals of controlling O&M costs. The report describes research results from an initial methodology for enhanced risk monitors by integrating real-time information about equipment condition and POF into risk monitors.

  18. Integrating Responsive Building Elements in Buildings

    DEFF Research Database (Denmark)

    Haase, Matthias; Amato, Alex; Heiselberg, Per

    2006-01-01

    energy strategies to develop guidelines and procedures for estimation of environmental performance of responsive building elements and integrated building concepts This paper introduces the ideas of this collaborative work and discusses its usefulness for Hong Kong and China. Special focus was put...

  19. Design of the Nonlinear Pin Rubber Forming Equipment Integrating the Functions of Extruding, Dewatering, Drying & Expanding

    Directory of Open Access Journals (Sweden)

    Yuefeng Yuan

    2014-12-01

    Full Text Available The top priority of car-tire suppliers is to improve wetland grip force of the using tires, reduce the rolling resistance and the rolling noise of tires. It is urgent for the tire industry to research and develop high-performance tires to solve the above problems. They must use the high- performance synthetic rubber and auxiliary rubber to develop the most advanced manufacturing technologies and equipment. Silica, a kind of important tire auxiliary rubber, can significantly reduce the rolling resistance of tires, improve the grip force and properties resistant to ice, wetness or slippery of tires. In this paper, based on the conventional tire rubber forming technologies of extrusion, dewatering, drying and expanding, a study is made on the conical screw, the dewatering barrel, the drying barrel, the pin layout scheme, the expanding die head, cutter and the control system. The nonlinear pin rubber forming equipment integrating the functions of extrusion, dewatering, drying and expanding is designed and applied to tire auxiliary rubber forming. The experiment shows that the forming device can realize the one-step forming, with high forming efficiency, low cost and less labor.

  20. Cloud-based shaft torque estimation for electric vehicle equipped with integrated motor-transmission system

    Science.gov (United States)

    Zhu, Xiaoyuan; Zhang, Hui; Yang, Bo; Zhang, Guichen

    2018-01-01

    In order to improve oscillation damping control performance as well as gear shift quality of electric vehicle equipped with integrated motor-transmission system, a cloud-based shaft torque estimation scheme is proposed in this paper by using measurable motor and wheel speed signals transmitted by wireless network. It can help reduce computational burden of onboard controllers and also relief network bandwidth requirement of individual vehicle. Considering possible delays during signal wireless transmission, delay-dependent full-order observer design is proposed to estimate the shaft torque in cloud server. With these random delays modeled by using homogenous Markov chain, robust H∞ performance is adopted to minimize the effect of wireless network-induced delays, signal measurement noise as well as system modeling uncertainties on shaft torque estimation error. Observer parameters are derived by solving linear matrix inequalities, and simulation results using acceleration test and tip-in, tip-out test demonstrate the effectiveness of proposed shaft torque observer design.

  1. Delivering on Industry Equipment Reliability Goals By Leveraging an Integration Platform and Decision Support Environment

    International Nuclear Information System (INIS)

    Coveney, Maureen K.; Bailey, W. Henry; Parkinson, William

    2004-01-01

    Utilities have invested in many costly enterprise systems - computerized maintenance management systems, document management systems, enterprise grade portals, to name but a few - and often very specialized systems, like data historians, high end diagnostic systems, and other focused and point solutions. From recent industry reports, we now know that the average nuclear power utilizes on average 1900 systems to perform daily work, of which 250 might facilitate the equipment reliability decision-making process. The time has come to leverage the investment in these systems by providing a common platform for integration and decision-making that will further the collective industry aim of enhancing the reliability of our nuclear generation assets to maintain high plant availability and to deliver on plant life extension goals without requiring additional large scale investment in IT infrastructure. (authors)

  2. A new method to determine J0-integral values (ASTM E 813) without any auxiliary equipment

    International Nuclear Information System (INIS)

    Ullrich, G.; Krompholz, K.

    1987-01-01

    In this contribution the path independent J-integral according to J.R. Rice, respective J.D. Landes and J.A. Begley due to ASTME 813 is calculated by the product J pl = d v J el for 3 point bend type specimen. Here d v is the load point displacement up to the point of the onset of stable crack growth V, which is taken from the load versus load point displacement diagram and J el a value which is equivalent to K 2 /E, where K is the stress intensity factor (ASTME 399) and E is Young's modulus. The advantage of the new procedure is the simplicity of the test arrangement and of the evaluation with the determination of initiation point V without computer or other auxiliary equipment. (orig.) [de

  3. An Updated Methodology for Enhancing Risk Monitors with Integrated Equipment Condition Assessment

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, Evelyn H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Coles, Garill A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bonebrake, Christopher A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Ivans, William J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Wootan, David W. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Mitchell, Mark R. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2014-07-18

    Small modular reactors (SMRs) generally include reactors with electric output of ~350 MWe or less (this cutoff varies somewhat but is substantially less than full-size plant output of 700 MWe or more). Advanced SMRs (AdvSMRs) refer to a specific class of SMRs and are based on modularization of advanced reactor concepts. Enhancing affordability of AdvSMRs will be critical to ensuring wider deployment, as AdvSMRs suffer from loss of economies of scale inherent in small reactors when compared to large (~greater than 600 MWe output) reactors and the controllable day-to-day costs of AdvSMRs will be dominated by operation and maintenance (O&M) costs. Technologies that help characterize real-time risk are important for controlling O&M costs. Risk monitors are used in current nuclear power plants to provide a point-in-time estimate of the system risk given the current plant configuration (e.g., equipment availability, operational regime, and environmental conditions). However, current risk monitors are unable to support the capability requirements listed above as they do not take into account plant-specific normal, abnormal, and deteriorating states of active components and systems. This report documents technology developments towards enhancing risk monitors that, if integrated with supervisory plant control systems, can provide the capability requirements listed and meet the goals of controlling O&M costs. The report describes research results on augmenting an initial methodology for enhanced risk monitors that integrate real-time information about equipment condition and POF into risk monitors. Methods to propagate uncertainty through the enhanced risk monitor are evaluated. Available data to quantify the level of uncertainty and the POF of key components are examined for their relevance, and a status update of this data evaluation is described. Finally, we describe potential targets for developing new risk metrics that may be useful for studying trade-offs for economic

  4. The integrated design of building services by an equipped and eco-efficient module (MOTE2

    Directory of Open Access Journals (Sweden)

    Roberto Giordano

    2016-12-01

    Full Text Available The targets set out by European Directives concerning the energy savings in the construction sector refer both to building envelope and to its services. With regard to building services it is mandatory meeting requirements related to heating, cooling, lighting and ventilation. Building services take up a variable space in the buildings that cannot be considered anymore negligible and they would always be fully integrated into buildings. Equipped and Eco-efficient Technological Module (MOTE2 is a research project aimed at implementing the integration in a unique services cupboard of some building services: heating and cooling; domestic hot water; mechanical ventilation. The project was organized according to four main phases. In phase 1 a set of rules was defined matching requirements related to the energy efficiency to environmental building design standards. During the phase 2 six building models were studied in order to size the corresponding building services according to scenario analysis set down for existing buildings. In phase 3 the project was focused on designing the assembly among services. The cupboard design is like a Tetris® game through the planning of the best combination among services shape. Based on the drawings developed a first mock-up was built up and monitored. Finally, in phase 4 the paper deals with the MOTE2’s expected performances. Outlook and some conclusions point out the future steps of the research activities.

  5. Development of generic floor response spectra for equipment qualification for seismic loads

    International Nuclear Information System (INIS)

    Curren, J.R.; Costantino, C.J.

    1984-01-01

    A generic floor response spectra has been developed for use in the qualification of electrical and mechanical equipment in operating nuclear power plants. Actual PWR and BWR - Mark I structural models were used as representative of a class of structures. For each model, the stiffness properties were varied, with the same mass, so as to extend the fundamental base structure natural frequency from 2 cps to 36 cps. This resulted in fundamental mode coupled natural frequencies as low as 0.86 cps and as high as 30 cps. The characteristics of 1000 floor response spectra were studied to determine the generic spectra. A procedure for its application to any operating plant has been established. The procedure uses as much or as little information that currently exists at the plant relating to the question of equipment qualification. A generic floor response spectra is proposed for the top level of a generic structure. Reduction factors are applied to the peak acceleration for equipment at lower levels

  6. Development of generic floor response spectra for equipment qualification for seismic loads

    International Nuclear Information System (INIS)

    Curreri, J.R.; Costantino, C.J.

    1984-10-01

    A generic floor response spectra has been developed for use in the qualification of electrical and mechanical equipment in operating nuclear power plants. Actual PWR and BWR - Mark I structural models were used as representative of a class of structures. For each model, the stiffness properties were varied, with the same mass, so as to extend the fundamental base structure natural frequency from 2 cps to 36 cps. This resulted in fundamental mode coupled natural frequencies as low as 0.86 cps and as high as 30 cps. The characteristics of 1000 floor response spectra were studied to determine the generic spectra. A procedure for its application to any operating plant has been established. The procedure uses as much or as little information that currently exists at the plant relating to the question of equipment qualification. A generic floor response spectra is proposed for the top level of a generic structure. Reduction factors are applied to the peak acceleration for equipment at lower levels

  7. Optomecatronic design and integration of a high resolution equipment Berkut to the 1-meter class telescopes

    Science.gov (United States)

    Granados, R.; López, R.; Farah, Alejandro

    2014-07-01

    It is proposed the development and implementation of a High Speed Resolution Camera instrument. The basic principle of this technique is to take several pictures of short exposure using different filters of an astronomical object of interest . These images are subsequently processed using specialized software to remove aberrations from atmosphere and from the instrument itself such as blur and scintillation among others. In this paper are described electronic and control systems implemented for BERKUT instrument based on FPGA (Field Programmable Gate Array) generated with VHDL description. An UART communication, using serial protocol, is used with a friendly User Interface providing an easy way for the astronomer to choose between different lenses and different filters for capturing the images. All the movements are produced by stepper motors that are driven by a circuit that powers all the electronics. The camera and the lenses are placed into a linear positioner with the help of a stepper motor which give us repeatable movements for positioning these optical components. Besides it is planned to integrate in the same system a pipeline for image data reduction to have one sturdy system that could fulfill any astronomer needs in the usage of this technique. With this instrument we pretend to confirm the Hipparcos catalogue of binary stars besides finding exoplanets. This technique requires more simple optical equipment and it is less sensitive to environmental noise, making it cheaper and provides good quality and great resolution images for scientific purposes. This equipment will be installed on different 1-m class telescopes in Mexico1 and probably other countries which makes it a wide application instrument.

  8. Seismic response analysis of Wolsung NPP structure and equipment subjected to scenario earthquakes

    Energy Technology Data Exchange (ETDEWEB)

    Choi, In Kil; Ahn, Seong Moon; Choun, Young Sun; Seo, Jeong Moon

    2005-03-15

    The standard response spectrum proposed by US NRC has been used as a design earthquake for the design of Korean nuclear power plant structures. However, it does not reflect the characteristic of seismological and geological of Korea. In this study, the seismic response analysis of Wolsung NPP structure and equipment were performed. Three types of input motions, artificial time histories that envelop the US NRC Regulatory Guide 1.60 spectrum and the probability based scenario earthquake spectra developed for the Korean NPP site and a typical near-fault earthquake recorded at thirty sites, were used as input motions. The acceleration, displacement and shear force responses of Wolsung containment structure due to the design earthquake were larger than those due to the other input earthquakes. But, considering displacement response increases abruptly as Wolsung NPP structure does nonlinear behavior, the reassessment of the seismic safety margin based on the displacement is necessary if the structure does nonlinear behavior; although it has adequate the seismic safety margin within elastic limit. Among the main safety-related devices, electrical cabinet and pump showed the large responses on the scenario earthquake which has the high frequency characteristic. This has great effects of the seismic capacity of the main devices installed inside of the building. This means that the design earthquake is not so conservative for the safety of the safety related nuclear power plant equipments.

  9. Seismic response analysis of Wolsung NPP structure and equipment subjected to scenario earthquakes

    International Nuclear Information System (INIS)

    Choi, In Kil; Ahn, Seong Moon; Choun, Young Sun; Seo, Jeong Moon

    2005-03-01

    The standard response spectrum proposed by US NRC has been used as a design earthquake for the design of Korean nuclear power plant structures. However, it does not reflect the characteristic of seismological and geological of Korea. In this study, the seismic response analysis of Wolsung NPP structure and equipment were performed. Three types of input motions, artificial time histories that envelop the US NRC Regulatory Guide 1.60 spectrum and the probability based scenario earthquake spectra developed for the Korean NPP site and a typical near-fault earthquake recorded at thirty sites, were used as input motions. The acceleration, displacement and shear force responses of Wolsung containment structure due to the design earthquake were larger than those due to the other input earthquakes. But, considering displacement response increases abruptly as Wolsung NPP structure does nonlinear behavior, the reassessment of the seismic safety margin based on the displacement is necessary if the structure does nonlinear behavior; although it has adequate the seismic safety margin within elastic limit. Among the main safety-related devices, electrical cabinet and pump showed the large responses on the scenario earthquake which has the high frequency characteristic. This has great effects of the seismic capacity of the main devices installed inside of the building. This means that the design earthquake is not so conservative for the safety of the safety related nuclear power plant equipments

  10. Equipment and physical plant changes in response to the Fukushima event

    International Nuclear Information System (INIS)

    Newman, G.

    2013-01-01

    The Fukushima event led the international nuclear industry and regulatory bodies to challenge the ability of existing nuclear power plants to prevent and mitigate the effects of a severe external event leading to a total loss of AC power and resultant loss of cooling. Canadian Nuclear Industry's immediate response was to provide a high level of assurance that the existing plant is in a high state of readiness to deal with design basis and beyond design basis events, verify the capability of the existing plant to deal with beyond design basis events (equipment, procedures, staff qualification, external support agreements, etc), verify capability to mitigate station black out events, verify capability to cope with internal and external floods and address vulnerabilities to seismically induced damage to mitigation equipment.

  11. Integrated equipment for increasing and maintaining coolant pressure in primary circuit of PWR nuclear power plant

    International Nuclear Information System (INIS)

    Sykora, D.

    1986-01-01

    An open heat pump circuit is claimed connected to the primary circuit. The pump circuit consists of a steam pressurizer with a built-in steam distributor, a compressor, an expander, a reducing valve, an auxiliary pump, and of water and steam pipes. The operation is described and a block diagram is shown of integrated equipment for increasing and maintaining pressure in the nuclear power plant primary circuit. The appropriate entropy diagram is also shown. The advantage of the open pump circuit consists in reducing the electric power input and electric power consumption for the steam pressurizers, removing entropy loss in heat transfer with high temperature gradient, in the possibility of inserting, between the expander and the auxiliary pump, a primary circuit coolant treatment station, in simplified design and manufacture of the high-pressure steam pressurizer vessel, reducing the weight of the steam pressurizer by changing its shape from cylindrical to spherical, increasing the rate of pressure growth in the primary circuit. (E.S.)

  12. Calculation of integrated biological response in brachytherapy

    International Nuclear Information System (INIS)

    Dale, Roger G.; Coles, Ian P.; Deehan, Charles; O'Donoghue, Joseph A.

    1997-01-01

    Purpose: To present analytical methods for calculating or estimating the integrated biological response in brachytherapy applications, and which allow for the presence of dose gradients. Methods and Materials: The approach uses linear-quadratic (LQ) formulations to identify an equivalent biologically effective dose (BED eq ) which, if applied to a specified tissue volume, would produce the same biological effect as that achieved by a given brachytherapy application. For simple geometrical cases, BED multiplying factors have been derived which allow the equivalent BED for tumors to be estimated from a single BED value calculated at a dose reference point. For more complex brachytherapy applications a voxel-by-voxel determination of the equivalent BED will be more accurate. Equations are derived which when incorporated into brachytherapy software would facilitate such a process. Results: At both high and low dose rates, the BEDs calculated at the dose reference point are shown to be lower than the true values by an amount which depends primarily on the magnitude of the prescribed dose; the BED multiplying factors are higher for smaller prescribed doses. The multiplying factors are less dependent on the assumed radiobiological parameters. In most clinical applications involving multiple sources, particularly those in multiplanar arrays, the multiplying factors are likely to be smaller than those derived here for single sources. The overall suggestion is that the radiobiological consequences of dose gradients in well-designed brachytherapy treatments, although important, may be less significant than is sometimes supposed. The modeling exercise also demonstrates that the integrated biological effect associated with fractionated high-dose-rate (FHDR) brachytherapy will usually be different from that for an 'equivalent' continuous low-dose-rate (CLDR) regime. For practical FHDR regimes involving relatively small numbers of fractions, the integrated biological effect to

  13. Active seismic response control systems for nuclear power plant equipment facilities

    International Nuclear Information System (INIS)

    Kobori, Takuji; Kanayama, Hiroo; Kamagata, Shuichi

    1989-01-01

    To sustain severe earthquake ground motion, a new type of anti-seismic structure is proposed, called a Dynamic Intelligent Building (DIB) system, which is positioned as an active seismic response controlled the structure. The structural concept starts from a new recognition of earthquake ground motion, and the structural natural frequency is actively adjusted to avoid resonant vibration, and similarly the external counter-force cancels the resonant force which comes from the dynamic structural motion energy. These concepts are verified using an analytical simulator program. The advanced application of the DIB system, is the Active Supporting system and the Active Stabilizer system for nuclear power plant equipment facilities. (orig.)

  14. Evaluating Attenuation of Vibration Response using Particle Impact Damping for a Range of Equipment Assemblies

    Science.gov (United States)

    Knight, Brent; Parsons, David; Smith, Andrew; Hunt, Ron; LaVerde, Bruce; Towner, Robert; Craigmyle, Ben

    2013-01-01

    Particle dampers provide a mechanism for diverting energy away from resonant structural vibrations. This experimental study provides data from a series of acoustically excited tests to determine the effectiveness of these dampers for equipment mounted to a curved orthogrid panel for a launch vehicle application. Vibration attenuation trends are examined for variations in particle damper fill level, component mass, and excitation energy. A significant response reduction at the component level was achieved, suggesting that comparatively small, strategically placed, particle damper devices might be advantageously used in launch vehicle design. These test results were compared to baseline acoustic response tests without particle damping devices, over a range of isolation and damping parameters. Instrumentation consisting of accelerometers, microphones, and still photography data will be collected to correlate with the analytical results.

  15. Development of floor design response spectra for seismic design of floor-supported equipment or components, Revision 1, February 1978

    International Nuclear Information System (INIS)

    Anon.

    1979-01-01

    This guide presents an acceptable method for developing two horizontal and one vertical floor design response spectra at various floor or other equipment-support locations from the time-history motions resulting from the dynamic analysis of the supporting structure. These floor design response spectra are used in the dynamic analysis of systems or equipment supported at various locations of the supporting structure. Consulation has been provided by the Advisory Committee on Reactor Safeguards

  16. Integrating Environmentally Responsive Elements in Buildings

    DEFF Research Database (Denmark)

    Heiselberg, Per

    2006-01-01

    Significant improvement have been achieved on efficiency improvements of specific building elements like the building envelope and building equipment and services and whilst most building elements still offer opportunities for efficiency improvements, the greatest future potential lie with techno......Significant improvement have been achieved on efficiency improvements of specific building elements like the building envelope and building equipment and services and whilst most building elements still offer opportunities for efficiency improvements, the greatest future potential lie...

  17. Cost-Effective Integration of Efficient Low-Lift Base Load Cooling Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Jiang, Wei; Winiarski, David W.; Katipamula, Srinivas; Armstrong, Peter R.

    2008-01-14

    The long-term goal of DOE’s Commercial Buildings Integration subprogram is to develop cost-effective technologies and building practices that will enable the design and construction of net Zero Energy Buildings — commercial buildings that produce as much energy as they use on an annual basis — by 2025. To support this long-term goal, DOE further called for — as part of its FY07 Statement of Needs — the development by 2010 of “five cost-effective design technology option sets using highly efficient component technologies, integrated controls, improved construction practices, streamlined commissioning, maintenance and operating procedures that will make new and existing commercial buildings durable, healthy and safe for occupants.” In response, PNNL proposed and DOE funded a scoping study investigation of one such technology option set, low-lift cooling, that offers potentially exemplary HVAC energy performance relative to ASHRAE Standard 90.1-2004. The primary purpose of the scoping study was to estimate the national technical energy savings potential of this TOS.

  18. Personal Protective Equipment Supply Chain: Lessons Learned from Recent Public Health Emergency Responses.

    Science.gov (United States)

    Patel, Anita; D'Alessandro, Maryann M; Ireland, Karen J; Burel, W Greg; Wencil, Elaine B; Rasmussen, Sonja A

    Personal protective equipment (PPE) that protects healthcare workers from infection is a critical component of infection control strategies in healthcare settings. During a public health emergency response, protecting healthcare workers from infectious disease is essential, given that they provide clinical care to those who fall ill, have a high risk of exposure, and need to be assured of occupational safety. Like most goods in the United States, the PPE market supply is based on demand. The US PPE supply chain has minimal ability to rapidly surge production, resulting in challenges to meeting large unexpected increases in demand that might occur during a public health emergency. Additionally, a significant proportion of the supply chain is produced off-shore and might not be available to the US market during an emergency because of export restrictions or nationalization of manufacturing facilities. Efforts to increase supplies during previous public health emergencies have been challenging. During the 2009 H1N1 influenza pandemic and the 2014 Ebola virus epidemic, the commercial supply chain of pharmaceutical and healthcare products quickly became critical response components. This article reviews lessons learned from these responses from a PPE supply chain and systems perspective and examines ways to improve PPE readiness for future responses.

  19. Handling equipment Selection in open pit mines by using an integrated model based on group decision making

    Directory of Open Access Journals (Sweden)

    Abdolreza Yazdani-Chamzini

    2012-10-01

    Full Text Available Process of handling equipment selection is one of the most important and basic parts in the project planning, particularly mining projects due to holding a high charge of the total project's cost. Different criteria impact on the handling equipment selection, while these criteria often are in conflicting with each other. Therefore, the process of handling equipment selection is a complex and multi criteria decision making problem. There are a variety of methods for selecting the most appropriate equipment among a set of alternatives. Likewise, according to the sophisticated structure of the problem, imprecise data, less of information, and inherent uncertainty, the usage of the fuzzy sets can be useful. In this study a new integrated model based on fuzzy analytic hierarchy process (FAHP and fuzzy technique for order preference by similarity to ideal solution (FTOPSIS is proposed, which uses group decision making to reduce individual errors. In order to calculate the weights of the evaluation criteria, FAHP is utilized in the process of handling equipment selection, and then these weights are inserted to the FTOPSIS computations to select the most appropriate handling system among a pool of alternatives. The results of this study demonstrate the potential application and effectiveness of the proposed model, which can be applied to different types of sophisticated problems in real problems.

  20. Role of closely spaced modes in the seismic response of equipment and structures

    International Nuclear Information System (INIS)

    Nelson, F.C.

    1975-01-01

    The genesis for this study was a need for an explanation of how to combine the peak accelerations, displacements, stresses, etc., which result from a response spectrum analysis of nuclear power plant structures and equipment. The explanation was intended to be comprehensive in the sense that it would be based on a general principle from which the absolute sum, square root of the sum of the squares (SRSS), and double-sum modal recombination rules could be extracted as special cases. The purpose of such a comprehensive explanation was to convince design engineers that these rules, in particular the recently proposed double-sum rule, were logical in their formulation and therefore sensible in their application

  1. 75 FR 54025 - Vessel and Facility Response Plans for Oil: 2003 Removal Equipment Requirements and Alternative...

    Science.gov (United States)

    2010-09-03

    ... responders for each vessel or facility with appropriate equipment and resources located in each zone of operation; specific lists of equipment that the resource providers will make available in case of an...

  2. The Ural Electrochemical Integrated Plant Process for Managing Equipment Intended for Nuclear Material Protection, Control and Accounting System Upgrades

    International Nuclear Information System (INIS)

    Yuldashev, Rashid; Nosov, Andrei; Carroll, Michael F.; Garrett, Albert G.; Dabbs, Richard D.; Ku, Esther M.

    2008-01-01

    Since 1996, the Ural Electrochemical Integrated Plant (UEIP) located in the town of Novouralsk, Russia, (previously known as Sverdlovsk-44) and the United States Department of Energy (U.S. DOE) have been cooperating under the Nuclear Material Protection, Control and Accounting (MPC and A) Program. Because UEIP is involved in the processing of highly enriched uranium (HEU) into low enriched uranium (LEU), and there are highly enriched nuclear materials on its territory, the main goal of the MPC and A cooperation is to upgrade those systems that ensure secure storage, processing and transportation of nuclear materials at the plant. UEIP has completed key upgrades (equipment procurement and installation) aimed at improving MPC and A systems through significant investments made by both the U.S. DOE and UEIP. These joint cooperative efforts resulted in bringing MPC and A systems into compliance with current regulations, which led to nuclear material (NM) theft risk reduction and prevention from other unlawful actions with respect to them. Upon the U.S. MPC and A project team's suggestion, UEIP has developed an equipment inventory control process to track all the property provided through the MPC and A Program. The UEIP process and system for managing equipment provides many benefits including: greater ease and efficiency in determining the quantities, location, maintenance and repair schedule for equipment; greater assurance that MPC and A equipment is in continued satisfactory operation; and improved control in the development of a site sustainability program. While emphasizing UEIP's equipment inventory control processes, this paper will present process requirements and a methodology that may have practical and helpful applications at other sites.

  3. An integrated approach to calculate life cycle costs of arms and military equipment

    OpenAIRE

    SOKOLOVIC VLADA S.; ANDREJIC MARKO D.; LJUBOJEVIC SRDJAN D.

    2013-01-01

    INTRODUCTION In a situation when government expenditures for defense are more restrictive, any investment in the acquisition of arms and military equipment (AME) is a question that does not allow errors in decisions. Accordingly, the economic analysis of the investment must be detailed and unavoidable. In the past, the initial cost of procurement of AME was often the primary, and sometimes the only one criterion in decision-making. Neglecting the analysis of costs throughout the life of asset...

  4. Power and Responsibility in Therapy: Integrating Feminism and Multiculturalism

    Science.gov (United States)

    Williams, Elizabeth Nutt; Barber, Jill S.

    2004-01-01

    The integration of feminist and multicultural approaches to psychotherapy, called for many times, has not yet materialized. This article reviews possible reasons this integration has not taken place and offers an approach to integration based on the guiding principles of power and responsibility, which builds on previous theories and approaches.

  5. IEC 61850. Integrated supervision of auxiliary power equipment; IEC 61850. Prozess und Eigenbedarf wachsen zusammen

    Energy Technology Data Exchange (ETDEWEB)

    Ostertag, Robert; Jung, Matthias [Siemens AG, Erlangen (Germany)

    2009-07-01

    It is state of technology today: Having process control and auxiliary power control integrated in one DCS. The integration is based on the international standard IEC 61850 which allows standardization of electrical structures from the process interface up to the DCS level. Modern control systems are designed to realize a system structure according to IEC 61850. A wide range of systems is available from systems with interfaces to realize a standardized data exchange up to systems with a complete integration of the standard IEC 61850. (orig.)

  6. Radiation protection and the safe use of X-ray equipment: Laws, regulations and responsibilities

    Directory of Open Access Journals (Sweden)

    Charles Petrus Herbst

    2012-06-01

    Full Text Available Lately, South Africa’s regulatory framework for electromagnetic medical devices has come under considerable pressure. In this article the legislative framework and regulatory infrastructure are scrutinized, by looking at how the legislature has given form to protective measures against ionizing radiation. Although the Hazardous Substances Act provides for effective protection against radiation, poor administration led to insufficient staffing levels, uncertainty about Regulations and licensing conditions and therefore undermines a sound radiation protection infrastructure. The legal basis of enforcing licensing conditions through a website without proper consultation with interested and affected parties is questionable and ineffective in controlling radiation levels. Effective and legal radiation control is possible by activating the National Advisory Committee on Electronic Products provided for in Regulation R326 published in 1979, but never implemented. The possible impact of annual quality assurance tests currently enforced through licensing conditions on the radiation dose of the population is not cost effective as new training and accreditation structures had to be created. The fact that generally more than 80% of overexposures are caused by human error is a clear indication that training of the daily users of X-ray equipment should be emphasized and not the training and accreditation of the technicians responsible for a single quality assurance test per year. Constructive engagement with the professional bodies involved in the medical use of X-rays through a National Advisory Committee on Electronic Products may be a cost effective solution for lowering radiation dose to the population.

  7. W-026 acceptance test report system integration equipment (SIE)(submittal {number_sign} 018.6.A)

    Energy Technology Data Exchange (ETDEWEB)

    Watson, T.L.

    1997-01-27

    Acceptance testing of the System Integration Equipment (SIE) at Hanford was performed in two stages. The first was inconclusive, and resulted in a number of findings. These finding. are summarized as part of this report. The second stage of testing addressed these findings, and performed full system testing per the approved test procedure. This report includes summaries of all testing, results and finding.. Although the SIE did not in some cases perform as required for plant operations, it did perform per the system specification. (These discrepancies were noted and are addressed elsewhere.) Following testing, the system was formaLLy accepted. Documentation of this acceptance is incLuded in this report.

  8. Integrated configurable equipment selection and line balancing for mass production with serial-parallel machining systems

    Science.gov (United States)

    Battaïa, Olga; Dolgui, Alexandre; Guschinsky, Nikolai; Levin, Genrikh

    2014-10-01

    Solving equipment selection and line balancing problems together allows better line configurations to be reached and avoids local optimal solutions. This article considers jointly these two decision problems for mass production lines with serial-parallel workplaces. This study was motivated by the design of production lines based on machines with rotary or mobile tables. Nevertheless, the results are more general and can be applied to assembly and production lines with similar structures. The designers' objectives and the constraints are studied in order to suggest a relevant mathematical model and an efficient optimization approach to solve it. A real case study is used to validate the model and the developed approach.

  9. Contribution of custom-designed integrated circuits to the electronic equipment of multiwire chambers

    International Nuclear Information System (INIS)

    Prunier, J.

    1977-01-01

    The first generations of circuits intended to equip the multiwire proportional chambers provided the user with logical type indications (absence or presence of a signal at a given place). This logical indication was soon associated with a semi-analog data (presence or absence of a signal above an analog threshold, i.e. the discrimination function) as with FILAS, RBA and RBB circuits. The evolution continued with the appearance of analog data capture (time, amplitude, charge) and the corresponding circuits: IFT circuits, analog-to-digital converters [fr

  10. Development of an EVA systems cost model. Volume 2: Shuttle orbiter crew and equipment translation concepts and EVA workstation concept development and integration

    Science.gov (United States)

    1975-01-01

    EVA crewman/equipment translational concepts are developed for a shuttle orbiter payload application. Also considered are EVA workstation systems to meet orbiter and payload requirements for integration of workstations into candidate orbiter payload worksites.

  11. Field Demonstration of Active Desiccant Modules Designed to Integrate with Standard Unitary Rooftop Package Equipment - Final Report: Phase 3

    Energy Technology Data Exchange (ETDEWEB)

    Fischer, J

    2004-03-15

    This report summarizes the investigation of two active desiccant module (ADM) pilot site installations initiated in 2001. Both pilot installations were retrofits at existing facilities served by conventional heating, ventilating, and air-conditioning (HVAC) systems that had encountered frequent humidity control, indoor air quality (IAQ), and other operational problems. Each installation involved combining a SEMCO, Inc., ADM (as described in Fischer and Sand 2002) with a standard packaged rooftop unit built by the Trane Company. A direct digital control (DDC) system integral to the ADM performed the dual function of controlling the ADM/rooftop combination and facilitating data collection, trending, and remote performance monitoring. The first installation involved providing preconditioned outdoor air to replace air exhausted from the large kitchen hood and bathrooms of a Hooters restaurant located in Rome, Georgia. This facility had previously added an additional rooftop unit in an attempt to achieve occupant comfort without success. The second involved conditioning the outdoor air delivered to each room of a wing of the Mountain Creek Inn at the Callaway Gardens resort. This hotel, designed in the ''motor lodge'' format with each room opening to the outdoors, is located in southwest Georgia. Controlling the space humidity always presented a serious challenge. Uncomfortable conditions and musty odors had caused many guests to request to move to other areas within the resort. This is the first field demonstration performed by Oak Ridge National Laboratory where significant energy savings, operating cost savings, and dramatically improved indoor environmental conditions can all be claimed as the results of a retrofit desiccant equipment field installation. The ADM/rooftop combination installed at the restaurant resulted in a reduction of about 34% in the electricity used by the building's air-conditioning system. This represents a reduction of

  12. Integrating Technology into Peer Leader Responsibilities

    Science.gov (United States)

    Johnson, Melissa L.

    2012-01-01

    Technology has become an integral part of landscape of higher education. Students are coming to college with an arsenal of technological tools at their disposal. These tools are being used for informal, everyday communication as well as for formal learning in the classroom. At the same time, higher education is experiencing an increase in peer…

  13. Integrated Disease Surveillance and Response Reporting

    African Journals Online (AJOL)

    Post-intervention assessment on the groups was done.We analysed ... statistically significant (χ = 16.31;df= 1;p< 0.0000) in the intervention group. Conclusion: The study ..... staff; Nurses, Midwives, Environmental. Health Officers ... may also be found at other tiers of healthcare delivery. .... Performance of Integrated Disease.

  14. Plant equipment integrity monitoring and diagnosing method and device therefor, plant equipment maintenance and inspection time determining method and device therefor, as well as nuclear power plant

    International Nuclear Information System (INIS)

    Kato, Takahiko; Ando, Masashi; Osumi, Katsumi; Horiuchi, Tetsuo; Asakura, Yamato; Akamine, Kazuhiko.

    1995-01-01

    The present invention can accurately forecast a time for occurrence of troubles of plant equipments in contact with recycling water, to conduct its maintenance and inspection before occurrence of the troubles. Namely, change of water quality in plant equipments caused by corrosion of recycling water occurred in constitutional parts of the plant equipments is measured. The time upon occurrence of the troubles of the plant equipments to corrosion of the recycling water is forecast based on the measured value. A time till the occurrence of the change of water quality after starting the use of the plant equipments is calculated based on the measured value. The calculated time is compared with a correlation between the time of occurrence of the troubles after starting the use of the plant equipments and the time of occurrence of change of the water quality, to forecast the time of occurrence of the troubles. Preferably, electroconductivity and pH of recycling water in the inside or at the exit of the plant equipments are measured as an object for the measurement of change of water quality. (I.S.)

  15. Containment Response Analysis for Equipment Qualification of Kori Nuclear Power Plant Unit 3 and 4

    Energy Technology Data Exchange (ETDEWEB)

    Byun, Choong Sup; Song, Dong Soo; Hwang, Yong Jun [Korea Electric Power Research Institute, Taejon (Korea, Republic of); Seo, Kwi Hyun; Song, Wan Jung [ENERGEO Inc., Sungnam (Korea, Republic of)

    2006-07-01

    Equipment that is used to perform a necessary safety function must be capable of maintaining functional operability under all service condition postulated to occur during the installed life for the time it is required. The pressure and temperature analyses for loss of coolant accident and main steam line break accident provide the bounding test envelope inside containment for the operability evaluation of safety equipment in harsh environmental. This paper describes the results of the containment pressure and temperature analysis for the equipment qualification (EQ) envelopes of Kori unit 3 and 4.

  16. A Model of Traceability for Equipments Using RFID Tehnologies within an Integrated System

    Directory of Open Access Journals (Sweden)

    Radu LIXANDROIU

    2006-01-01

    Full Text Available Radio Frequency Identification (RFID is an automatic identification method, relying on storing and remotely retrieving data using devices called RFID tagss or transponders. An advanced automatic identification technology such as the Auto-ID system based on the Radio Frequency Identification (RFID technology has two values for inventory systems. First, the visibility provided by this technology allows an accurate knowledge on the inventory level by eliminating the discrepancy between inventory record and physical inventory. Second, the RFID technology can prevent or reduce the sources of errors. Benefits of using RFID include the reduction of labor costs, the simplification of business processes and the reduction of inventory inaccuracies. Also, RFID technology allows an knowledge on the traceability of equipments in a organization.

  17. EIRP Characterization of Electrically Large Wireless Equipment with Integrated Signal Generator in a Compact Environment

    Directory of Open Access Journals (Sweden)

    Soon-Soo Oh

    2015-01-01

    Full Text Available We describe a measurement technique to characterize the equivalent isotropically radiated power (EIRP of electrically large wireless equipment in a compact environment. A modified phase-measurement method was proposed and, thus, the separation of the signal generator and radiating element was not required during the measurement. A Fresnel-to-far-field transformation was used for the fast measurement time in a compact anechoic chamber. An experimental verification of the method was carried out in a compact anechoic chamber, where the source-detector separation was approximately 1/5 of the far-field distance. The measured magnitude and phase pattern exhibited only a small error. The EIRP obtained using a Fresnel-to-far-field transformation was compared with a reference value, and the error was within 0.5 dB.

  18. EQUIPMENT FOR NONDESTRUCTIVE TESTING OF SILICON WAFERS SUBMICRON TOPOLOGY DURING THE FABRICATION OF INTEGRATED CIRCUITS

    Directory of Open Access Journals (Sweden)

    S. A. Chizhik

    2013-01-01

    Full Text Available The advantages of using an atomic force microscopy in manufacturing of submicron integrated circuits are described. The possibilities of characterizing the surface morphology and the etching profile for silicon substrate and bus lines, estimation of the periodicity and size of bus lines, geometrical stability for elementary bus line are shown. Methods of optical and atomic force microcopies are combined in one diagnostic unit. Scanning  probe  microscope  (SPM  200  is  designed  and  produced.  Complex  SPM  200  realizes  nondestructive control of microelectronics elements made on silicon wafers up to 200 mm in diameter and it is introduced by JSC «Integral» for the purpose of operational control, metrology and acceptance of the final product.

  19. Plasticity of Neuron-Glial Transmission: Equipping Glia for Long-Term Integration of Network Activity

    Directory of Open Access Journals (Sweden)

    Wayne Croft

    2015-01-01

    Full Text Available The capacity of synaptic networks to express activity-dependent changes in strength and connectivity is essential for learning and memory processes. In recent years, glial cells (most notably astrocytes have been recognized as active participants in the modulation of synaptic transmission and synaptic plasticity, implicating these electrically nonexcitable cells in information processing in the brain. While the concept of bidirectional communication between neurons and glia and the mechanisms by which gliotransmission can modulate neuronal function are well established, less attention has been focussed on the computational potential of neuron-glial transmission itself. In particular, whether neuron-glial transmission is itself subject to activity-dependent plasticity and what the computational properties of such plasticity might be has not been explored in detail. In this review, we summarize current examples of plasticity in neuron-glial transmission, in many brain regions and neurotransmitter pathways. We argue that induction of glial plasticity typically requires repetitive neuronal firing over long time periods (minutes-hours rather than the short-lived, stereotyped trigger typical of canonical long-term potentiation. We speculate that this equips glia with a mechanism for monitoring average firing rates in the synaptic network, which is suited to the longer term roles proposed for astrocytes in neurophysiology.

  20. Plasma and process characterization of high power magnetron physical vapor deposition with integrated plasma equipment--feature profile model

    International Nuclear Information System (INIS)

    Zhang Da; Stout, Phillip J.; Ventzek, Peter L.G.

    2003-01-01

    High power magnetron physical vapor deposition (HPM-PVD) has recently emerged for metal deposition into deep submicron features in state of the art integrated circuit fabrication. However, the plasma characteristics and process mechanism are not well known. An integrated plasma equipment-feature profile modeling infrastructure has therefore been developed for HPM-PVD deposition, and it has been applied to simulating copper seed deposition with an Ar background gas for damascene metalization. The equipment scale model is based on the hybrid plasma equipment model [M. Grapperhaus et al., J. Appl. Phys. 83, 35 (1998); J. Lu and M. J. Kushner, ibid., 89, 878 (2001)], which couples a three-dimensional Monte Carlo sputtering module within a two-dimensional fluid model. The plasma kinetics of thermalized, athermal, and ionized metals and the contributions of these species in feature deposition are resolved. A Monte Carlo technique is used to derive the angular distribution of athermal metals. Simulations show that in typical HPM-PVD processing, Ar + is the dominant ionized species driving sputtering. Athermal metal neutrals are the dominant deposition precursors due to the operation at high target power and low pressure. The angular distribution of athermals is off axis and more focused than thermal neutrals. The athermal characteristics favor sufficient and uniform deposition on the sidewall of the feature, which is the critical area in small feature filling. In addition, athermals lead to a thick bottom coverage. An appreciable fraction (∼10%) of the metals incident to the wafer are ionized. The ionized metals also contribute to bottom deposition in the absence of sputtering. We have studied the impact of process and equipment parameters on HPM-PVD. Simulations show that target power impacts both plasma ionization and target sputtering. The Ar + ion density increases nearly linearly with target power, different from the behavior of typical ionized PVD processing. The

  1. Implementation of new integrated evaporation equipment for the preparation of 238U targets and improvement of the deposition process

    Science.gov (United States)

    Vanleeuw, D.; Lewis, D.; Moens, A.; Sibbens, G.; Wiss, T.

    2018-05-01

    Measurement of neutron cross section data is a core activity of the JRC-Directorate G for Nuclear Safety and Security in Geel. After a period of reduced activity and in line with a renewed interest for nuclear data required for GenIV reactors and waste minimization, the demand for high quality actinide targets increased. Physical vapour deposition by thermal evaporation is a key technique to prepare homogeneous thin actinide layers, but due to ageing effects the earlier in-house developed equipment can no longer provide the required quality. Because of a current lack of experience and human resources cooperation with private companies is required for the development of new deposition equipment directly integrated in a glove box. In this paper we describe the design, implementation and validation of the first commercial actinide evaporator in a glove box as well as the optimization of the deposition process. Highly enriched 238U3O8 was converted to 238UF4 powder and several deposition runs were performed on different substrates. The deposition parameters were varied and defined in order to guarantee physical and chemical stable homogeneous UF4 layers, even on polished substrates which was not longer feasible with the older equipment. The stability problem is discussed in view of the thin layer growth by physical vapour deposition and the influence of the deposition parameters on the layer quality. The deposits were characterized for the total mass by means of substitution weighing and for the areal density of 238U by means of alpha particle counting and thermal ionization mass spectrometry (TIMS). The quality of the layer was visually evaluated and by means of stereo microscopy and auto radiography.

  2. Effects of supporting structures on dynamic response of nuclear power plant equipment and piping systems

    International Nuclear Information System (INIS)

    Stoykovich, M.

    1982-01-01

    This paper presents the evaluation of the effects of supporting structures in dynamic analysis of equipment or piping systems, which involves formulations for determining reduced stiffness and mass matrices associated with the number of degrees of freedom corresponding to the support nodal points of a finite element model. Also, evaluation of a composite damping matrix associated with different damping properties of supporting structures, equipment, and piping systems is considered. Determination of spring constants, effective masses and mass moments of inertia, and damping values as fractions of critical damping on the basis of the theory of rigid bases on the surfaces of an elastic halfspace is demonstrated

  3. Information-integration category learning and the human uncertainty response.

    Science.gov (United States)

    Paul, Erick J; Boomer, Joseph; Smith, J David; Ashby, F Gregory

    2011-04-01

    The human response to uncertainty has been well studied in tasks requiring attention and declarative memory systems. However, uncertainty monitoring and control have not been studied in multi-dimensional, information-integration categorization tasks that rely on non-declarative procedural memory. Three experiments are described that investigated the human uncertainty response in such tasks. Experiment 1 showed that following standard categorization training, uncertainty responding was similar in information-integration tasks and rule-based tasks requiring declarative memory. In Experiment 2, however, uncertainty responding in untrained information-integration tasks impaired the ability of many participants to master those tasks. Finally, Experiment 3 showed that the deficit observed in Experiment 2 was not because of the uncertainty response option per se, but rather because the uncertainty response provided participants a mechanism via which to eliminate stimuli that were inconsistent with a simple declarative response strategy. These results are considered in the light of recent models of category learning and metacognition.

  4. Armenian NPP experience in assuring of vital equipment's integrity (by the means of Aging Management)

    International Nuclear Information System (INIS)

    Sevikyan, G.A.

    2012-01-01

    The purpose of this paper is to shortly represent the Armenian Nuclear Power Plant with its peculiar history. Thanks to responsible and attentive treatment of duties of all plant's personnel the Unit is operating during more than fifteen years without failures and incidents. In the given review the most vivid examples of timely revealing of defects which could lead to serious negative consequences are presented. (author)

  5. Double-shell tank integrity assessments ultrasonic test equipment performance test

    Energy Technology Data Exchange (ETDEWEB)

    Pfluger, D.C.

    1996-09-26

    A double-shell tank (DST) inspection (DSTI) system was performance tested over three months until August 1995 at Pittsburgh, Pennsylvania, completing a contract initiated in February 1993 to design, fabricate, and test an ultrasonic inspection system intended to provide ultrasonic test (UT) and visual data to determine the integrity of 28 DSTs at Hanford. The DSTs are approximately one-million-gallon underground radioactive-waste storage tanks. The test was performed in accordance with a procedure (Jensen 1995) that included requirements described in the contract specification (Pfluger 1995). This report documents the results of tests conducted to evaluate the performance of the DSTI system against the requirements of the contract specification. The test of the DSTI system also reflects the performance of qualified personnel and operating procedures.

  6. Safeguards equipment of the future integrated monitoring systems and remote monitoring

    International Nuclear Information System (INIS)

    Sonnier, C.S.; Johnson, C.S.

    1994-01-01

    Becoming aware of the significant events of the past four years and their effect on the expectations to international safeguards, it is necessary to reflect on which direction the development of nuclear safeguards in a new era needs to take and the implications. The lime proven monitoring techniques, based on quantitative factor's and demonstrated universal application, have shown their merit. However, the new expectations suggest a possibility that a future IAEA safeguards system could rely more heavily on the value of a comprehensive, transparent and open implementation regime. Within such a regime, the associated measures need to be determined and technological support identified. This paper will identify the proven techniques which, with appropriate implementation support, could most quickly make available additional measures for a comprehensive, transparent and open implementation regime. In particular, it will examine the future of Integrated Monitoring Systems and Remote Monitoring in international safeguards, including technical and other related factors

  7. RESUME-95: Results of an International Field Test of Mobile Equipment for Emergency Response

    DEFF Research Database (Denmark)

    Hovgaard, Jens; Scott, Marian

    1997-01-01

    In 1995 the exercise RESUME-95 (Rapid Environmental Surveying Using Mobile Equipment) took place in Finland. Groups from 8 European countries joined the exercise. The methods used were airborne gamma-ray measurements, car-borne measurements and in situ stationary measurements. The results of the ...

  8. Integrating Corporate Social Responsibility Awareness into a Retail Management Course

    Science.gov (United States)

    Beitelspacher, Lauren; Rodgers, Vikki L.

    2018-01-01

    Both students and industry are demanding that marketing instructors incorporate discussions of environmental and social responsibility into their courses. Marketing educators play a critical role in developing the knowledge and skills students need to effectively integrate corporate social responsibility (CSR) into their future business endeavors.…

  9. Preliminary Study for Development of Welds Integrity Verification Equipment for the Small Bore Piping

    International Nuclear Information System (INIS)

    Choi, Geun Suk; Lee, Jong Eun; Ryu, Jung Hoon; Cho, Kyoung Youn; Sohn, Myoung Sung; Lee, Sanghoon; Sung, Gi Ho; Cho, Hong Seok

    2016-01-01

    It has been reported leakage accident of small-bore piping in Korea. Leakage accident of small-bore pipes are those that will increase due to the aging of the nuclear power plant. And if leakage of the pipe is repaired by using the clamping device when it occur accident, it is economically benefits. The clamping device is a fastening device used to hold or secure objects tightly together to prevent movement or separation through the application of inward pressure. However, when the accident occurs, it can't immediately respond because maintenance and repairing technology are not institutionalized in KEPIC. Thus it appears an economic loss. The technology for corresponding thereto is necessary for the safety of the operation of nuclear power plants. The purpose of this research is to develop an online repairing technology of socket welded pipe and vibration monitoring system of small-bore pipe in the nuclear power plant. Specifically, detailed studies are as follows : • Development of weld overlay method of safety class socket welded connections • Development of Mechanical Clamping Devices for Safety Class 2, 3 small-bore pipe. The purpose of this study is to develop an online repairing technology of socket welded pipe and vibration monitoring system of small-bore pipe, resulting in degraded plant systems. And it is necessary to institutionalize the technology. The fatigue crack testing of socket welded overlay will be performed and fatigue life evaluation method will be developed in second year. Also prototype fabrication of mechanical clamping device will be completed. Base on final goal, the intent is to propose practical evaluation tools, design and fabrication methods for socket welded connection integrity. And result of this study is to development of KEPIC code case approved technology for on-line repairing system of socket welded connection and fabrication of mechanical clamping device

  10. Evaluation of the structural integrity of LMFBR equipment cell liners: results of preliminary investigations

    International Nuclear Information System (INIS)

    McAfee, W.J.; Sartory, W.K.

    1976-01-01

    The behavior of a plane wall segment of a prototype liquid-metal-cooled fast breeder reactor (LMFBR) cell under conditions of a postulated massive sodium spill was studied. Sodium-concrete reaction calculations were performed assuming an initial flaw existed in the liner such that high-temperature sodium could penetrate to the concrete underneath. Based on existing sodium-concrete reaction rate data, bounding values were established for the maximum energy release per unit volume of concrete. The potential effect of this energy release on the deformation of the liner material was determined. The temperature buildup in the liner and the pressure differential across the flaw in the liner were also studied. The transient thermal and structural responses of the steel liner and backup concrete were analyzed in detail using the inelastic computer code ANSYS. The literature on the mechanical, physical, and general behavior properties of concrete at high temperature was reviewed. This review emphasized the structural behavior of concrete and did not cover the sodium-concrete reaction

  11. Beam simulation of synchrotron radiation equipment. New method responsive to three dimensional magnetic field

    International Nuclear Information System (INIS)

    Tanaka, Hirofumi

    1999-01-01

    A new numerical analysis method capable of precise modeling of complex three dimensional magnetic field of superconducting wiggler and of long-term beam simulation without destroying property of Hamiltonian dynamics system was developed by using the above-mentioned method. Therefore, a fundamental design of a compact synchrotron radiation equipment with hexagonal column shape was also developed. Its main parameters had 1 GeV in energy, 36 m in circumference, 300 mA in stored current, and 184 nmrad in emittance. So as to enable to research the x-ray and vacuum UV regions, a superconducting wiggler with 7T in magnetic field strength and an undulator were set at straight section. It depends upon if beam around stable region on exciting the superconducting wiggler is wider than the required region whether this type of synchrotron radiation equipment can be realized or not. By using three orbit analysis methods containing the developed one, the circulating stable region was introduced. As a result, although shape of the stable region was different from used methods, it was found that considerably larger stable region was obtained than the required in circulation results of every three methods. That is to say, it was shown that the designed compact equipment can accumulate electron beams stably. (G.K.)

  12. Thermal Integration of CO{sub 2} Compression Processes with Coal-Fired Power Plants Equipped with Carbon Capture

    Energy Technology Data Exchange (ETDEWEB)

    Edward Levy

    2012-06-29

    Coal-fired power plants, equipped either with oxycombustion or post-combustion CO{sub 2} capture, will require a CO{sub 2} compression system to increase the pressure of the CO{sub 2} to the level needed for sequestration. Most analyses show that CO{sub 2} compression will have a significant effect on parasitic load, will be a major capital cost, and will contribute significantly to reduced unit efficiency. This project used first principle engineering analyses and computer simulations to determine the effects of utilizing compressor waste heat to improve power plant efficiency and increase net power output of coal-fired power plants with carbon capture. This was done for units with post combustion solvent-based CO{sub 2} capture systems and for oxyfired power plants, firing bituminous, PRB and lignite coals. The thermal integration opportunities analyzed for oxycombustion capture are use of compressor waste heat to reheat recirculated flue gas, preheat boiler feedwater and predry high-moisture coals prior to pulverizing the coal. Among the thermal integration opportunities analyzed for post combustion capture systems are use of compressor waste heat and heat recovered from the stripper condenser to regenerate post-combustion CO{sub 2} capture solvent, preheat boiler feedwater and predry high-moisture coals. The overall conclusion from the oxyfuel simulations is that thermal integration of compressor heat has the potential to improve net unit heat rate by up to 8.4 percent, but the actual magnitude of the improvement will depend on the type of heat sink used and to a lesser extent, compressor design and coal rank. The simulations of a unit with a MEA post combustion capture system showed that thermal integration of either compressor heat or stripper condenser heat to preheat boiler feedwater would result in heat rate improvements from 1.20 percent to 4.19 percent. The MEA capture simulations further showed that partial drying of low rank coals, done in combination

  13. INNOVATIVE INTEGRATION OF SOCIAL RESPONSIBILITY IN BUSINESS STRATEGY

    OpenAIRE

    ALBU MĂDĂLINA

    2015-01-01

    Innovative integration of social responsibility in the decision making in companies and other organizations, is an activity that causes immediate positive effect on those directly involved, on local communities and society as a whole. Setting up a framework to promote and implement the concept of social responsibility is an important factor for promoting economic development and sustainable development of local communities and society in general. The paper presents aspects of how ...

  14. Instantaneous response spectrum in seismic testing of nuclear power plant equipment

    International Nuclear Information System (INIS)

    Morrone, A.

    1977-01-01

    This paper presents the concept of instantaneous response spectrum (IRS) as the response of single degree of freedom oscillators at a particular time. It demonstrates that a shake table random motion whose standard TRS envelops the RRS does not necessarily satisfy the enveloping requirement instantaneously. That is, any one (or more) instantaneous required response spectrum (IRRS) is not enveloped by any instantaneous test response spectrum (ITRS). Response spectra from different time histories, including single frequency sine beat motion used in resonance testing, are compared for enveloping with maximum response and with the actual response at particular times. These comparisons are given for the enveloping of RRS and IRRS derived with a time history response calculated at a particular building elevation of a nuclear power plant. For the test motion, several of the most severe ITRS derived with a modified EL Centro motion and with a sine beat motion with ten cycles per beat were used. It is shown that although the TRS with the modified EL Centro motion enveloped the given RRS, the selected modified EL Centro ITRS did not envelop the corresponding IRRS. With the sine beat motion, even though the TRS did not fully envelop the given RRS, the resulting sine beat ITRS did not require a larger factor for full IRRS enveloping than those of the modified EL Centro motion

  15. Assessment of the TRANSREC-350 mechanical recovery capacity of the oil spill response equipment in Prince William Sound

    International Nuclear Information System (INIS)

    Provant, S.G.

    1992-01-01

    Studies were conducted to determine the compliance of oil spill response equipment in Prince William Sound, Alaska, to state standards. Data on the observed performance of the Framo TRANSREC skimmer, which represents a large portion of the initial response skimming capability of the Sound's equipment, were obtained from Norwegian experience. The results of the analysis are based on the level of performance expected from well-trained skimmer crews responding to a 300,000 bbl spill under the worst average weather conditions over a 72-h period. Certain assumptions are made about volumes of evaporation and decanting. Results indicate that the volume of oil expected to be recovered would be 188,900 bbl, which would expand via emulsion formation to 303,000 bbl. In addition, a volume of free water would be taken in with the emulsion, which would be reduced by decanting. The overall storage capacity needed would then be 382,300 bbl. With the present available configuration of skimmers and barges, the maximum available storage capacity is 370,000 bbl. Skimmer capability can be maximized by matching storage capacity to recovery capability or by developing and demonstrating a capability to offload the recovered oil effectively such that transfer operations do not materially affect recovery operations. Recommendations are made for spill response organizations to improve their operations. 4 refs., 9 figs

  16. A BENCHMARK PROGRAM FOR EVALUATION OF METHODS FOR COMPUTING SEISMIC RESPONSE OF COUPLED BUILDING-PIPING/EQUIPMENT WITH NON-CLASSICAL DAMPING

    International Nuclear Information System (INIS)

    Xu, J.; Degrassi, G.; Chokshi, N.

    2001-01-01

    Under the auspices of the US Nuclear Regulatory Commission (NRC), Brookhaven National Laboratory (BNL) developed a comprehensive program to evaluate state-of-the-art methods and computer programs for seismic analysis of typical coupled nuclear power plant (NPP) systems with nonclassical damping. In this program, four benchmark models of coupled building-piping/equipment systems with different damping characteristics were analyzed for a suite of earthquakes by program participants applying their uniquely developed methods and computer programs. This paper presents the results of their analyses, and their comparison to the benchmark solutions generated by BNL using time domain direct integration methods. The participant's analysis results established using complex modal time history methods showed good comparison with the BNL solutions, while the analyses produced with either complex-mode response spectrum methods or classical normal-mode response spectrum method, in general, produced more conservative results, when averaged over a suite of earthquakes. However, when coupling due to damping is significant, complex-mode response spectrum methods performed better than the classical normal-mode response spectrum method. Furthermore, as part of the program objectives, a parametric assessment is also presented in this paper, aimed at evaluation of the applicability of various analysis methods to problems with different dynamic characteristics unique to coupled NPP systems. It is believed that the findings and insights learned from this program will be useful in developing new acceptance criteria and providing guidance for future regulatory activities involving licensing applications of these alternate methods to coupled systems

  17. Comparison of Integrated Testlet and Constructed-Response Question Formats

    Science.gov (United States)

    Slepkov, Aaron D.; Shiell, Ralph C.

    2014-01-01

    Constructed-response (CR) questions are a mainstay of introductory physics textbooks and exams. However, because of the time, cost, and scoring reliability constraints associated with this format, CR questions are being increasingly replaced by multiple-choice (MC) questions in formal exams. The integrated testlet (IT) is a recently developed…

  18. A Responsive, Integrative Spanish Curriculum at UNC Charlotte

    Science.gov (United States)

    Doyle, Michael S.

    2010-01-01

    The Spanish program at UNC Charlotte is timely and responsive because it is designed to meet documented societal (job market) needs in today's and tomorrow's global village and economy by providing graduates with strong specialties in English-Spanish translating and in business Spanish. It is integrative in that it does so while maintaining its…

  19. Radiation response of high speed CMOS integrated circuits

    International Nuclear Information System (INIS)

    Yue, H.; Davison, D.; Jennings, R.F.; Lothongkam, P.; Rinerson, D.; Wyland, D.

    1987-01-01

    This paper studies the total dose and dose rate radiation response of the FCT family of high speed CMOS integrated circuits. Data taken on the devices is used to establish the dominant failure modes, and this data is further analyzed using one-sided tolerance factors for normal distribution statistical analysis

  20. An integrated management systems approach to corporate social responsibility.

    NARCIS (Netherlands)

    Asif, M.; Searcy, C.; Zutshi, A.; Fisscher, O.A.M.

    2011-01-01

    A great deal of research has emphasized the strategic management of corporate social responsibility (CSR). However, gaps remain on how CSR can be effectively integrated with existing business processes. One key question remaining is how to design business processes so that they accommodate

  1. Protecting Financial Market Integrity: Roles and Responsibilities of Auditors

    NARCIS (Netherlands)

    P.A.M. Diekman (Peter)

    2008-01-01

    textabstractWaarom heeft u nog vertrouwen in een bank? En waarom vertrouwt u uw geld nog toe aan banken? Deze vragen staan centraal in de oratie ‘Protecting Financial Market Integrity. Roles and Responsibilities of Auditors' van prof.dr. Peter A.M. Diekman RA. Hij stelt dat zowel de intern als de

  2. 30 CFR 254.42 - Exercises for your response personnel and equipment.

    Science.gov (United States)

    2010-07-01

    ..., communication, and decisionmaking in managing a response. You must not reveal the spill scenario to team members... the complete 3-year exercise cycle. Records should be maintained at the facility or at a corporate...

  3. Life sciences payload definition and integration study, task C and D. Volume 4: Preliminary equipment item specification catalog

    Science.gov (United States)

    1973-01-01

    A specification catalog to define the equipment to be used for conducting life sciences experiments in a space laboratory is presented. The specification sheets list the purpose of the equipment item, and any specific technical requirements which can be identified. The status of similar hardware for ground use is stated with comments regarding modifications required to achieve spaceflight qualified hardware. Pertinent sketches, commercial catalog sheets, or drawings of the applicable equipment are included.

  4. Emergency Response Equipment and Related Training: Airborne Radiological Computer System (Model II)

    Energy Technology Data Exchange (ETDEWEB)

    David P. Colton

    2007-02-28

    The materials included in the Airborne Radiological Computer System, Model-II (ARCS-II) were assembled with several considerations in mind. First, the system was designed to measure and record the airborne gamma radiation levels and the corresponding latitude and longitude coordinates, and to provide a first overview look of the extent and severity of an accident's impact. Second, the portable system had to be light enough and durable enough that it could be mounted in an aircraft, ground vehicle, or watercraft. Third, the system must control the collection and storage of the data, as well as provide a real-time display of the data collection results to the operator. The notebook computer and color graphics printer components of the system would only be used for analyzing and plotting the data. In essence, the provided equipment is composed of an acquisition system and an analysis system. The data can be transferred from the acquisition system to the analysis system at the end of the data collection or at some other agreeable time.

  5. Emergency Response Equipment and Related Training: Airborne Radiological Computer System (Model II) user's manual

    International Nuclear Information System (INIS)

    David P. Colton

    2007-01-01

    The materials included in the Airborne Radiological Computer System, Model-II (ARCS-II) were assembled with several considerations in mind. First, the system was designed to measure and record the airborne gamma radiation levels and the corresponding latitude and longitude coordinates, and to provide a first overview look of the extent and severity of an accident's impact. Second, the portable system had to be light enough and durable enough that it could be mounted in an aircraft, ground vehicle, or watercraft. Third, the system must control the collection and storage of the data, as well as provide a real-time display of the data collection results to the operator. The notebook computer and color graphics printer components of the system would only be used for analyzing and plotting the data. In essence, the provided equipment is composed of an acquisition system and an analysis system. The data can be transferred from the acquisition system to the analysis system at the end of the data collection or at some other agreeable time

  6. On the response of a reactor building and its equipment to aircraft crash

    International Nuclear Information System (INIS)

    Larsson, G.; Lundsager, P.

    1977-01-01

    The present study investigates the dynamic response of the ASEA-ATOM BWR 75 reactor building in terms of response spectra at significant locations considering various aircraft and points of load application. In the first part of the study a total of 21 forcing functions, most of them from the open literature and including the commonly used standard functions, have been studied with respect to documentation, consistency and frequency content. Since none of the forcing functions have been experimentally verified, their validity must be assessed mainly by judging the structural models and assumptions used in their derivation and by checking their consistency. In the second part, linear dynamical models of various degrees of detailedness have been investigated regarding their capacity to describe the behavior of the reactor building under this high frequency loading. The most detailed model consists of plane stress finite elements for every significant wall and floor. In the third part of the study the effects of a number of parameters on the response of the building are investigated. The parameters include the points of attack, damping values, soil spring stiffness as well as different forcing functions of various frequency contents. The reponse is displayed as response spectra and member forces for characteristic locations. The results serve as a basis for development of standardized design floor response spectra and for the structural verification of the bui

  7. Exercise Equipment: Neutral Buoyancy

    Science.gov (United States)

    Shackelford, Linda; Valle, Paul

    2016-01-01

    Load Bearing Equipment for Neutral Buoyancy (LBE-NB) is an exercise frame that holds two exercising subjects in position as they apply counter forces to each other for lower extremity and spine loading resistance exercises. Resistance exercise prevents bone loss on ISS, but the ISS equipment is too massive for use in exploration craft. Integrating the human into the load directing, load generating, and motion control functions of the exercise equipment generates safe exercise loads with less equipment mass and volume.

  8. Coupled lateral-torsional response of equipment mounted in CANDU nuclear power plants

    International Nuclear Information System (INIS)

    Ishac, M.F.; Heidebrecht, A.C.

    1979-01-01

    In this paper, a coupled lateral torsional model (CLTM) is developed as a modification of the uncoupled lateral torsional model (ULTM) by including the torsional degree of freedom for each mass point and taking into consideration the effect of eccentricities between the centers of mass and rigidity at each floor level. The lateral and rotational time-histories at each floor level are characterized by lateral and rotational floor response spectra at the mass centroid. These time-histories are also combined to determine the lateral floor response spectra at the extreme edges of each floor mass. (orig.)

  9. Integration of Corporate Social Responsibility and Corporate Communication

    OpenAIRE

    Islam, Mohammad Nur

    2017-01-01

    The purpose of this study is to present a new perspective on the current practices in corporate communications and CSR which calls for an integration of social responsibility and communication activities of corporations as an opportunity of competitive advantage. More specifically, this study looks at this subject from the angle of how companies can use communications to achieve CSR goal, while CSR can be a way to attain efficacy in communication. The study is designed to examine the current ...

  10. Using frequency response functions to manage image degradation from equipment vibration in the Daniel K. Inouye Solar Telescope

    Science.gov (United States)

    McBride, William R.; McBride, Daniel R.

    2016-08-01

    The Daniel K Inouye Solar Telescope (DKIST) will be the largest solar telescope in the world, providing a significant increase in the resolution of solar data available to the scientific community. Vibration mitigation is critical in long focal-length telescopes such as the Inouye Solar Telescope, especially when adaptive optics are employed to correct for atmospheric seeing. For this reason, a vibration error budget has been implemented. Initially, the FRFs for the various mounting points of ancillary equipment were estimated using the finite element analysis (FEA) of the telescope structures. FEA analysis is well documented and understood; the focus of this paper is on the methods involved in estimating a set of experimental (measured) transfer functions of the as-built telescope structure for the purpose of vibration management. Techniques to measure low-frequency single-input-single-output (SISO) frequency response functions (FRF) between vibration source locations and image motion on the focal plane are described. The measurement equipment includes an instrumented inertial-mass shaker capable of operation down to 4 Hz along with seismic accelerometers. The measurement of vibration at frequencies below 10 Hz with good signal-to-noise ratio (SNR) requires several noise reduction techniques including high-performance windows, noise-averaging, tracking filters, and spectral estimation. These signal-processing techniques are described in detail.

  11. Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

    Science.gov (United States)

    Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.

    1986-01-01

    Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

  12. The Integration Role of European Defense Procurement in Achieving a More Competitive and Stronger European Defense Equipment Market

    Science.gov (United States)

    2015-06-01

    and systems, even monopolistic ) essence of the supply side of the defense market . There are only a few suppliers that can meet today’s complex...DEFENSE PROCUREMENT IN ACHIEVING A MORE COMPETITIVE AND STRONGER EUROPEAN DEFENSE EQUIPMENT MARKET by Kiril O. Angelov June 2015 Thesis Advisor...COMPETITIVE AND STRONGER EUROPEAN DEFENSE EQUIPMENT MARKET 5. FUNDING NUMBERS 6. AUTHOR(S) Kiril O. Angelov 7. PERFORMING ORGANIZATION NAME(S) AND

  13. Integrating Social Media Monitoring Into Public Health Emergency Response Operations.

    Science.gov (United States)

    Hadi, Tamer A; Fleshler, Keren

    2016-10-01

    Social media monitoring for public health emergency response and recovery is an essential response capability for any health department. The value of social media for emergency response lies not only in the capacity to rapidly communicate official and critical incident information, but as a rich source of incoming data that can be gathered to inform leadership decision-making. Social media monitoring is a function that can be formally integrated into the Incident Command System of any response agency. The approach to planning and required resources, such as staffing, logistics, and technology, is flexible and adaptable based on the needs of the agency and size and scope of the emergency. The New York City Department of Health and Mental Hygiene has successfully used its Social Media Monitoring Team during public health emergency responses and planned events including major Ebola and Legionnaires' disease responses. The concepts and implementations described can be applied by any agency, large or small, interested in building a social media monitoring capacity. (Disaster Med Public Health Preparedness. 2016;page 1 of 6).

  14. Macrophage proinflammatory response to the titanium alloy equipment in dental implantation.

    Science.gov (United States)

    Chen, X; Li, H S; Yin, Y; Feng, Y; Tan, X W

    2015-08-07

    Titanium alloy and stainless steel (SS) had been widely used as dental implant materials because of their affinity with epithelial tissue and connective tissue, and good physical, chemical, biological, mechanical properties and processability. We compared the effects of titanium alloy and SS on macrophage cytokine expression as well as their biocompatibility. Mouse macrophage RAW264.7 cells were cultured on titanium alloy and SS surfaces. Cells were counted by scanning electron microscopy. A nitride oxide kit was used to detect released nitric oxide by macrophages on the different materials. An enzyme linked immunosorbent assay was used to detect monocyte chemoattractant protein-1 levels. Scanning electron microscopy revealed fewer macrophages on the surface of titanium alloy (48.2 ± 6.4 x 10(3) cells/cm(2)) than on SS (135 ± 7.3 x 10(3) cells/cm(2)). The nitric oxide content stimulated by titanium alloy was 22.5 mM, which was lower than that stimulated by SS (26.8 mM), but the difference was not statistically significant (P = 0.07). The level of monocyte chemoattractant protein-1 released was significantly higher in the SS group (OD value = 0.128) than in the titanium alloy group (OD value = 0.081) (P = 0.024). The transforming growth factor-b1 mRNA expression levels in macrophages after stimulation by titanium alloy for 12 and 36 h were significantly higher than that after stimulation by SS (P = 0.31 and 0.25, respectively). Macrophages participate in the inflammatory response by regulating cytokines such as nitric oxide, monocyte chemoattractant protein-1, and transforming growth factor-b1. There were fewer macrophages and lower inflammation on the titanium alloy surface than on the SS surface. Titanium alloy materials exhibited better biological compatibility than did SS.

  15. Grid Integration of Aggregated Demand Response, Part 2: Modeling Demand Response in a Production Cost Model

    Energy Technology Data Exchange (ETDEWEB)

    Hummon, Marissa [National Renewable Energy Lab. (NREL), Golden, CO (United States); Palchak, David [National Renewable Energy Lab. (NREL), Golden, CO (United States); Denholm, Paul [National Renewable Energy Lab. (NREL), Golden, CO (United States); Jorgenson, Jennie [National Renewable Energy Lab. (NREL), Golden, CO (United States); Olsen, Daniel J. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Kiliccote, Sila [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Matson, Nance [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Sohn, Michael [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Rose, Cody [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Dudley, Junqiao [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Goli, Sasank [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States); Ma, Ookie [U.S. Dept. of Energy, Washington, DC (United States)

    2013-12-01

    This report is one of a series stemming from the U.S. Department of Energy (DOE) Demand Response and Energy Storage Integration Study. This study is a multi-national-laboratory effort to assess the potential value of demand response (DR) and energy storage to electricity systems with different penetration levels of variable renewable resources and to improve our understanding of associatedmarkets and institutions. This report implements DR resources in the commercial production cost model PLEXOS.

  16. Corporate Social Responsibility and Organizational Psychology: An Integrative Review.

    Science.gov (United States)

    Glavas, Ante

    2016-01-01

    The author reviews the corporate social responsibility (CSR) literature that includes the individual level of analysis (referred to as micro CSR in the article) based on 166 articles, book chapters, and books. A framework is provided that integrates organizational psychology and CSR, with the purpose of highlighting synergies in order to advance scholarship and practice in both fields. The review is structured so that first, a brief overview is provided. Second, the literatures on organizational psychology and CSR are integrated. Third, gaps are outlined illuminating opportunities for future research. Finally, a research agenda is put forward that goes beyond addressing gaps and focuses on how organizational psychology and CSR can be partners in helping move both fields forward-specifically, through a humanistic research agenda rooted in positive psychology.

  17. Corporate Social Responsibility and Organizational Psychology: An Integrative Review

    Science.gov (United States)

    Glavas, Ante

    2016-01-01

    The author reviews the corporate social responsibility (CSR) literature that includes the individual level of analysis (referred to as micro CSR in the article) based on 166 articles, book chapters, and books. A framework is provided that integrates organizational psychology and CSR, with the purpose of highlighting synergies in order to advance scholarship and practice in both fields. The review is structured so that first, a brief overview is provided. Second, the literatures on organizational psychology and CSR are integrated. Third, gaps are outlined illuminating opportunities for future research. Finally, a research agenda is put forward that goes beyond addressing gaps and focuses on how organizational psychology and CSR can be partners in helping move both fields forward—specifically, through a humanistic research agenda rooted in positive psychology. PMID:26909055

  18. Evaluation of TLD dose response compared to MCNP-5 simulation of diagnostic X ray equipment - radiation diagnostic image

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez G, R.; Cavalieri, T. A.; De Paiva, F.; Dalledone S, P. de T.; Yoriyaz, H. [Instituto de Pesquisas Energeticas e Nucleares, Centro de Engenharia Nuclear / CNEN, Av. Lineu Prestes 2242, Cidade Universitaria, 05508-000 Sao Paulo (Brazil); Rodrigues F, M. A. [Universidade Estadual Paulista, Faculdade de Medicina de Botucatu, Departamento de Dermatologia e Radioterapia, Av. Prof. Montenegro s/n, Rubiao Junior, 18601-970 Botucatu (Brazil); Vivolo, V., E-mail: chancez@hotmail.com [Instituto de Pesquisas Energeticas e Nucleares, Gerencia de Metrologia das Radiacoes / CNEN, Av. Lineu Prestes 2242, Cidade Universitaria, 05508-000 Sao Paulo (Brazil)

    2014-08-15

    The thermo luminescent dosimeter (TLD) is used as a radiation dosimeter and can be used as environmental and staff personnel monitoring. The TLD measures ionizing radiation exposure by a process in which the amount of radiation collected by the dosimeter is converted in visible light when the crystal is heated. The amount of emitted light is proportional to the radiation exposure, and then the response of the TLD must be the related to the real dose. In this work it was used twenty four TLD 700 in order to obtain eight values of doses from a diagnostic X-ray equipment. The TLD-700 is a LiF TLD enriched with {sup 7}Li isotope. One way to compare and study the response of TLD is by Monte Carlo method, which has been used as a computational tool to solve problems stochastically. This method can be applied to any geometry, even those where the boundary conditions are unknown, making the method particularly useful to solve problems a priori. In this work it was modeled the X-ray tube exactly as the one used to irradiate the TLD, after the simulation and the TLD irradiation the results of dose value from both were compared. (Author)

  19. Evaluation of TLD dose response compared to MCNP-5 simulation of diagnostic X ray equipment - radiation diagnostic image

    International Nuclear Information System (INIS)

    Sanchez G, R.; Cavalieri, T. A.; De Paiva, F.; Dalledone S, P. de T.; Yoriyaz, H.; Rodrigues F, M. A.; Vivolo, V.

    2014-08-01

    The thermo luminescent dosimeter (TLD) is used as a radiation dosimeter and can be used as environmental and staff personnel monitoring. The TLD measures ionizing radiation exposure by a process in which the amount of radiation collected by the dosimeter is converted in visible light when the crystal is heated. The amount of emitted light is proportional to the radiation exposure, and then the response of the TLD must be the related to the real dose. In this work it was used twenty four TLD 700 in order to obtain eight values of doses from a diagnostic X-ray equipment. The TLD-700 is a LiF TLD enriched with 7 Li isotope. One way to compare and study the response of TLD is by Monte Carlo method, which has been used as a computational tool to solve problems stochastically. This method can be applied to any geometry, even those where the boundary conditions are unknown, making the method particularly useful to solve problems a priori. In this work it was modeled the X-ray tube exactly as the one used to irradiate the TLD, after the simulation and the TLD irradiation the results of dose value from both were compared. (Author)

  20. An integrated approach to shoreline mapping for spill response planning

    International Nuclear Information System (INIS)

    Owens, E.H.; LeBlanc, S.R.; Percy, R.J.

    1996-01-01

    A desktop mapping package was introduced which has the capability to provide consistent and standardized application of mapping and data collection/generation techniques. Its application in oil spill cleanup was discussed. The data base can be updated easily as new information becomes available. This provides a response team with access to a wide range of information that would otherwise be difficult to obtain. Standard terms and definitions and shoreline segmentation procedures are part of the system to describe the shore-zone character and shore-zone oiling conditions. The program that is in place for Atlantic Canada involves the integration of (1) Environment Canada's SCAT methodology in pre-spill data generation, (2) shoreline segmentation, (3) response management by objectives, (4) Environment Canada's national sensitivity mapping program, and (5) Environment Canada's field guide for the protection and treatment of oiled shorelines. 7 refs., 6 figs

  1. Transient rheology of stimuli responsive hydrogels: Integrating microrheology and microfluidics

    Science.gov (United States)

    Sato, Jun

    Stimuli-responsive hydrogels have diverse potential applications in the field of drug delivery, tissue engineering, agriculture, cosmetics, gene therapy, and as sensors and actuators due to their unique responsiveness to external signals, such as pH, temperature, and ionic strength. Understanding the responsiveness of hydrogel structure and rheology to these stimuli is essential for designing materials with desirable performance. However, no instrumentation and well-defined methodology are available to characterize the structural and rheological responses to rapid solvent changes. In this thesis, a new microrheology set-up is described, which allows us to quantitatively measure the transient rheological properties and microstructure of a variety of solvent-responsive complex fluids. The device was constructed by integrating particle tracking microrheology and microfluidics and offers unique experimental capabilities for performing solvent-reponse measurements on soft fragile materials without applying external shear forces. Transient analysis methods to quantitatively obtain rheological properties were also constructed, and guidelines for the trade-off between statistical validity and temporal resolution were developed to accurately capture physical transitions. Employing the new device and methodology, we successfully quantified the transient rheological and microstructural responses during gel formation and break-up, and viscosity changes of solvent-responsive complex fluids. The analysis method was expanded for heterogeneous samples, incorporating methods to quantify the microrheology of samples with broad distributions of individual particle dynamics. Transient microrheology measurements of fragile, heterogeneous, self-assembled block copolypeptide hydrogels revealed that solvent exchange via convective mixing and dialysis can lead to significantly different gel properties and that commonly applied sample preparation protocols for the characterization of soft

  2. INNOVATIVE INTEGRATION OF SOCIAL RESPONSIBILITY IN BUSINESS STRATEGY

    Directory of Open Access Journals (Sweden)

    ALBU MĂDĂLINA

    2015-12-01

    Full Text Available Innovative integration of social responsibility in the decision making in companies and other organizations, is an activity that causes immediate positive effect on those directly involved, on local communities and society as a whole. Setting up a framework to promote and implement the concept of social responsibility is an important factor for promoting economic development and sustainable development of local communities and society in general. The paper presents aspects of how McDonald's Romania treated with the utmost seriousness social responsibilities under its leadership, using all resources to contribute to a better world. The company must be continuously aware of its impact on the environment and the community, including these issues in its future strategy. Synergy between social responsibility activities of companies and their goals of business is a sure way to be successful on the market, this can be highlighted in the case study conducted at McDonald's Romania, a company that wants to use his position leadership to ensure that benefit ethical, environmental and economic.

  3. Integrative modeling of transcriptional regulation in response to antirheumatic therapy

    Directory of Open Access Journals (Sweden)

    Thiesen Hans-Juergen

    2009-08-01

    Full Text Available Abstract Background The investigation of gene regulatory networks is an important issue in molecular systems biology and significant progress has been made by combining different types of biological data. The purpose of this study was to characterize the transcriptional program induced by etanercept therapy in patients with rheumatoid arthritis (RA. Etanercept is known to reduce disease symptoms and progression in RA, but the underlying molecular mechanisms have not been fully elucidated. Results Using a DNA microarray dataset providing genome-wide expression profiles of 19 RA patients within the first week of therapy we identified significant transcriptional changes in 83 genes. Most of these genes are known to control the human body's immune response. A novel algorithm called TILAR was then applied to construct a linear network model of the genes' regulatory interactions. The inference method derives a model from the data based on the Least Angle Regression while incorporating DNA-binding site information. As a result we obtained a scale-free network that exhibits a self-regulating and highly parallel architecture, and reflects the pleiotropic immunological role of the therapeutic target TNF-alpha. Moreover, we could show that our integrative modeling strategy performs much better than algorithms using gene expression data alone. Conclusion We present TILAR, a method to deduce gene regulatory interactions from gene expression data by integrating information on transcription factor binding sites. The inferred network uncovers gene regulatory effects in response to etanercept and thus provides useful hypotheses about the drug's mechanisms of action.

  4. APPLICATION OF EQUIPMENT FOR AUTOMATIC CONTROL OF PLANAR STRUCTURES IN MANUFACTURING MASTER MASKS OF INTEGRATED CIRCUITS ON PHOTO-MASKS

    Directory of Open Access Journals (Sweden)

    S. M. Avakov

    2007-01-01

    Full Text Available Following the concept of defect-free manufacturing of master masks of IC on photo-masks, two Belarusian sets of optomechanical equipment for 0,3 5 p and 90 nanometers are presented in the paper. Each of the sets comprises:   • Multi-channel laser pattern generator; • Automatic mask defect inspection system; • Laser-based mask defect repair system.The paper contains description of automatic mask defect inspection process during photo-mask manufacturing and respective basic technological operations of the processes.Advantages of a complex approach to the development of a set of opto-mechanical equipment for defect-free manufacturing of photo-masks have been analyzed in the paper. 

  5. Shaping the Future: Integrating Cutting Edge Equipment to Enhance Research, Education and Outreach at Nova Southeastern University

    Science.gov (United States)

    2015-04-30

    antibiotic resistance and preventing the spread of infectious disease . These projects include 1) uncovering how the inoculum effect can drive spontaneous...bacterial infections. Furthermore, our results may have implications in controlling the spread of infectious diseases and the spread of invasive...equipment. For instance, a new faculty member starting this fall will be bringing dental pulp stem cells, collaborations will continue with pharmacology

  6. Cuidar integral da equipe multiprofissional: discurso de mulheres em pré-operatório de mastectomia

    Directory of Open Access Journals (Sweden)

    Karla Tamyres Santos do Nascimento

    2014-09-01

    Full Text Available Objetivo: Investigar a atuação da equipe multiprofissional, no que tange a preparação de mulheres em pré-operatório de mastectomia. Métodos: Trata-se de uma pesquisa exploratória com abordagem qualitativa, realizada na clínica cirúrgica de um hospital público, em João Pessoa - PB. A amostra foi composta por sete mulheres que iriam se submeter à mastectomia. A coleta de dados foi iniciada após parecer favorável do Comitê de Ética em Pesquisa nº 751/10 e CAAE nº 0578.0.126.000-10, no período de fevereiro a maio de 2011, por meio da técnica de entrevista gravada. Resultados: Os dados obtidos foram analisados mediante a técnica do Discurso do sujeito coletivo, gerando quatro ideias centrais, destacando a atuação da equipe multiprofissional, contemplando orientações pertinentes ao procedimento cirúrgico, pré-operatórias, apoio psicológico, espiritual e nutricional. Conclusão: Conclui-se que existe a necessidade de uma maior integração da equipe multiprofissional, para propiciar melhor assistência à mulher no período pré-operatório de mastectomia.

  7. Medical equipment management

    CERN Document Server

    Willson, Keith; Tabakov, Slavik

    2013-01-01

    Know What to Expect When Managing Medical Equipment and Healthcare Technology in Your Organization As medical technology in clinical care becomes more complex, clinical professionals and support staff must know how to keep patients safe and equipment working in the clinical environment. Accessible to all healthcare professionals and managers, Medical Equipment Management presents an integrated approach to managing medical equipment in healthcare organizations. The book explains the underlying principles and requirements and raises awareness of what needs to be done and what questions to ask. I

  8. Comparison of integrated testlet and constructed-response question formats

    Directory of Open Access Journals (Sweden)

    Aaron D. Slepkov

    2014-09-01

    Full Text Available Constructed-response (CR questions are a mainstay of introductory physics textbooks and exams. However, because of the time, cost, and scoring reliability constraints associated with this format, CR questions are being increasingly replaced by multiple-choice (MC questions in formal exams. The integrated testlet (IT is a recently developed question structure designed to provide a proxy of the pedagogical advantages of CR questions while procedurally functioning as set of MC questions. ITs utilize an answer-until-correct response format that provides immediate confirmatory or corrective feedback, and they thus allow not only for the granting of partial credit in cases of initially incorrect reasoning, but, furthermore, the ability to build cumulative question structures. Here, we report on a study that directly compares the functionality of ITs and CR questions in introductory physics exams. To do this, CR questions were converted to concept-equivalent ITs, and both sets of questions were deployed in midterm and final exams. We find that both question types provide adequate discrimination between stronger and weaker students, with CR questions discriminating slightly better than the ITs. There is some indication that any difference in discriminatory power may result from the baseline score for guessing that is inherent in MC testing. Meanwhile, an analysis of interrater scoring of the CR questions raises serious concerns about the reliability of the granting of partial credit when this traditional assessment technique is used in a realistic (but nonoptimized setting. Furthermore, we show evidence that partial credit is granted in a valid manner in the ITs. Thus, together with consideration of the vastly reduced costs of administering IT-based examinations compared to CR-based examinations, our findings indicate that ITs are viable replacements for CR questions in formal examinations where it is desirable both to assess concept integration and to

  9. Twenty-third water reactor safety information meeting. Volume 3, structural and seismic engineering, primary systems integrity, equipment operability and aging, ECCS strainer blockage research and regulatory issues

    Energy Technology Data Exchange (ETDEWEB)

    Monteleone, S. [comp.] [Brookhaven National Lab., Upton, NY (United States)

    1996-03-01

    This three-volume report contains papers presented at the Twenty- Third Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23-25, 1995. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Italy, Japan, Norway, Russia, Sweden, and Switzerland. This document, Volume 3, presents topics in Structural & Seismic Engineering, Primary Systems Integrity, Equipment Operability and Aging, and ECCS Strainer Blockage Research & Regulatory Issues. Individual papers have been cataloged separately.

  10. Twenty-third water reactor safety information meeting. Volume 3, structural and seismic engineering, primary systems integrity, equipment operability and aging, ECCS strainer blockage research and regulatory issues

    International Nuclear Information System (INIS)

    Monteleone, S.

    1996-03-01

    This three-volume report contains papers presented at the Twenty- Third Water Reactor Safety Information Meeting held at the Bethesda Marriott Hotel, Bethesda, Maryland, October 23-25, 1995. The papers are printed in the order of their presentation in each session and describe progress and results of programs in nuclear safety research conducted in this country and abroad. Foreign participation in the meeting included papers presented by researchers from France, Italy, Japan, Norway, Russia, Sweden, and Switzerland. This document, Volume 3, presents topics in Structural ampersand Seismic Engineering, Primary Systems Integrity, Equipment Operability and Aging, and ECCS Strainer Blockage Research ampersand Regulatory Issues. Individual papers have been cataloged separately

  11. Study of developing nuclear fabrication facility's integrated emergency response manual

    International Nuclear Information System (INIS)

    Kim, Taeh Yeong; Cho, Nam Chan; Han, Seung Hoon; Moon, Jong Han; Lee, Jin Hang; Min, Guem Young; Han, Ji Ah

    2016-01-01

    Public begin to pay attention to emergency management. Thus, public's consensus on having high level of emergency management system up to advanced country's is reached. In this social atmosphere, manual is considered as key factor to prevent accident or secure business continuity. Therefore, we first define possible crisis at KEPCO Nuclear Fuel (hereinafter KNF) and also make a 'Reaction List' for each crisis situation at the view of information-design. To achieve it, we analyze several country's crisis response manual and then derive component, indicate duties and roles at the information-design point of view. From this, we suggested guideline to make 'Integrated emergency response manual(IERM)'. The manual we used before have following few problems; difficult to applicate at the site, difficult to deliver information. To complement these problems, we searched manual elements from the view of information-design. As a result, we develop administrative manual. Although, this manual could be thought as fragmentary manual because it confined specific several agency/organization and disaster type

  12. Integrated Stress Response Mediates Epithelial Injury in Mechanical Ventilation.

    Science.gov (United States)

    Dolinay, Tamas; Himes, Blanca E; Shumyatcher, Maya; Lawrence, Gladys Gray; Margulies, Susan S

    2017-08-01

    Ventilator-induced lung injury (VILI) is a severe complication of mechanical ventilation that can lead to acute respiratory distress syndrome. VILI is characterized by damage to the epithelial barrier with subsequent pulmonary edema and profound hypoxia. Available lung-protective ventilator strategies offer only a modest benefit in preventing VILI because they cannot impede alveolar overdistension and concomitant epithelial barrier dysfunction in the inflamed lung regions. There are currently no effective biochemical therapies to mitigate injury to the alveolar epithelium. We hypothesize that alveolar stretch activates the integrated stress response (ISR) pathway and that the chemical inhibition of this pathway mitigates alveolar barrier disruption during stretch and mechanical ventilation. Using our established rat primary type I-like alveolar epithelial cell monolayer stretch model and in vivo rat mechanical ventilation that mimics the alveolar overdistension seen in acute respiratory distress syndrome, we studied epithelial responses to mechanical stress. Our studies revealed that the ISR signaling pathway is a key modulator of epithelial permeability. We show that prolonged epithelial stretch and injurious mechanical ventilation activate the ISR, leading to increased alveolar permeability, cell death, and proinflammatory signaling. Chemical inhibition of protein kinase RNA-like endoplasmic reticulum kinase, an upstream regulator of the pathway, resulted in decreased injury signaling and improved barrier function after prolonged cyclic stretch and injurious mechanical ventilation. Our results provide new evidence that therapeutic targeting of the ISR can mitigate VILI.

  13. Equipment considerations

    International Nuclear Information System (INIS)

    Anon.

    1992-01-01

    Trace or ultratrace analyses require that the HPLC equipment used, including the detector, be optimal for such determinations. HPLC detectors are discussed at length in Chapter 4; discussion here is limited to the rest of the equipment. In general, commercial equipment is adequate for trace analysis; however, as the authors approach ultratrace analysis, it becomes very important to examine the equipment thoroughly and optimize it, where possible. For this reason they will review the equipment commonly used in HPLC and discuss the optimization steps. Detectability in HPLC is influenced by two factors (1): (a) baseline noise or other interferences that lead to errors in assigning the baseline absorbance; (b) peak width. 87 refs

  14. Interim staff position on environmental qualification of safety-related electrical equipment: including staff responses to public comments. Regulatory report

    International Nuclear Information System (INIS)

    Szukiewicz, A.J.

    1981-07-01

    This document provides the NRC staff positions regarding selected areas of environmental qualification of safety-related electrical equipment, in the resolution of Unresolved Safety Issue A-24, 'Qualification of Class IE Safety-Related Equipment.' The positions herein are applicable to plants that are or will be in the construction permit (CP) or operating license (OL) review process and that are required to satisfy the requirements set forth in either the 1971 or the 1974 version of IEEE-323 standard

  15. Seismic and dynamic qualification of safety-related electrical and mechanical equipment in operating nuclear power plants: development of a method to generate generic floor-response spectra

    International Nuclear Information System (INIS)

    Curreri, J.; Costantino, C.; Subudhi, M.; Reich, M.

    1983-09-01

    Generic floor response spectra were developed for use in the qualification of electrical and mechanical equipment in operating nuclear power plants. The characteristics of 1000 floor response spectra were studied to determine the generic spectra. The procedure developed uses as much or as little information that currently exists at the plant relating to the question of equipment qualification. The general approach was to study the effects on the dynamic characteristics of each of the elements in the chain of events that goes between the loads and the responses. This includes the loads, the soils and the structures. A free-field earthquake response spectra was used to generate horizontal earthquake time histories. The excitation was applied through the soil and into the various structures to produce responses in equipment. An entire range of soil conditions was used with each structure. Actual PWR and BWR - Mark I structural models were used. For each model, the stiffness properties were varied, with the same mass, so as to extend the fundamental base structure natural frequency from 2 cps to 36 cps. The natural frequencies of the structures were varied to obtain maximum response conditions. The actual properties were first used to locate the natural frequencies. The stiffness properties were than varied, with the same mass, to extend the range of the fundamental base structure natural frequency. The intention was to have the coupled structural material frequencies in the vicinity of the peak amplitude frequency content of the excitation spectrum. Particular attention was therefore given to the frequency band between 2 Hz and 4 Hz. A horizontal generic floor response spectra is proposed for the top level of a generic structure. Reduction factors are applied to the peak acceleration for equipment at lower levels

  16. Triggers for virtual customer integration in the development of medical equipment – from a manufacturer and a user perspective

    DEFF Research Database (Denmark)

    Füller, Johann; Faullant, Rita; Matzler, Kurt

    2010-01-01

    that looks at the motivations of customers and managers to engage in virtual product development projects. In this paper we try to identify the triggers for virtual customer integration (VCI) from the manager's as well as from the customer's perspective. Using Ajzen's Theory of Planned Behavior we aim...

  17. Radiation therapy sources, equipment and installations

    International Nuclear Information System (INIS)

    2011-03-01

    The safety code for Telegamma Therapy Equipment and Installations, (AERB/SC/MED-1) and safety code for Brachytherapy Sources, Equipment and Installations, (AERB/SC/MED-3) were issued by AERB in 1986 and 1988 respectively. These codes specified mandatory requirements for radiation therapy facilities, covering the entire spectrum of operations ranging from the setting up of a facility to its ultimate decommissioning, including procedures to be followed during emergency situations. The codes also stipulated requirements of personnel and their responsibilities. With the advent of new techniques and equipment such as 3D-conformal radiation therapy, intensity modulated radiation therapy, image guided radiation therapy, treatment planning system, stereotactic radiosurgery, stereotactic radiotherapy, portal imaging, integrated brachytherapy and endovascular brachytherapy during the last two decades, AERB desires that these codes be revised and merged into a single code titled Radiation Therapy Sources, Equipment, and Installations

  18. Electronic equipment packaging technology

    CERN Document Server

    Ginsberg, Gerald L

    1992-01-01

    The last twenty years have seen major advances in the electronics industry. Perhaps the most significant aspect of these advances has been the significant role that electronic equipment plays in almost all product markets. Even though electronic equipment is used in a broad base of applications, many future applications have yet to be conceived. This versatility of electron­ ics has been brought about primarily by the significant advances that have been made in integrated circuit technology. The electronic product user is rarely aware of the integrated circuits within the equipment. However, the user is often very aware of the size, weight, mod­ ularity, maintainability, aesthetics, and human interface features of the product. In fact, these are aspects of the products that often are instrumental in deter­ mining its success or failure in the marketplace. Optimizing these and other product features is the primary role of Electronic Equipment Packaging Technology. As the electronics industry continues to pr...

  19. Approximate calculation method for integral of mean square value of nonstationary response

    International Nuclear Information System (INIS)

    Aoki, Shigeru; Fukano, Azusa

    2010-01-01

    The response of the structure subjected to nonstationary random vibration such as earthquake excitation is nonstationary random vibration. Calculating method for statistical characteristics of such a response is complicated. Mean square value of the response is usually used to evaluate random response. Integral of mean square value of the response corresponds to total energy of the response. In this paper, a simplified calculation method to obtain integral of mean square value of the response is proposed. As input excitation, nonstationary white noise and nonstationary filtered white noise are used. Integrals of mean square value of the response are calculated for various values of parameters. It is found that the proposed method gives exact value of integral of mean square value of the response.

  20. O papel da odontologia na equipe interdisciplinar: contribuindo para a atenção integral ao idoso

    OpenAIRE

    Shinkai Rosemary Sadami Arai; Del Bel Cury Altair Antoninha

    2000-01-01

    Este trabalho bibliográfico teve por objetivo discutir a atuação da odontologia na atenção integral à saúde do idoso, considerando-se a necessidade da abordagem interdisciplinar. É apresentada a atual situação da odontologia geriátrica e os problemas que ocorrem no Brasil pela falta de estudos específicos e de recursos humanos capacitados em geriatria e gerontologia dentro da odontologia. São destacadas as interações entre as diversas profissões de saúde e a odontologia, para a promoção de sa...

  1. Equipping providers with principles, knowledge and skills to successfully integrate behaviour change counselling into practice: a primary healthcare framework.

    Science.gov (United States)

    Vallis, M; Lee-Baggley, D; Sampalli, T; Ryer, A; Ryan-Carson, S; Kumanan, K; Edwards, L

    2018-01-01

    There is an urgent need for healthcare providers and healthcare systems to support productive interactions with patients that promote sustained health behaviour change in order to improve patient and population health outcomes. Behaviour change theories and interventions have been developed and evaluated in experimental contexts; however, most healthcare providers have little training, and therefore low confidence in, behaviour change counselling. Particularly important is how to integrate theory and method to support healthcare providers to engage in behaviour change counselling competently. In this article, we describe a general training model developed from theory, evidence, experience and stakeholder engagement. This model will set the stage for future evaluation research on training needed to achieve competency, sustainability of competency, as well as effectiveness/cost-effectiveness of training in supporting behaviour change. A framework to support competency based training in behaviour change counselling is described in this article. This framework is designed to be integrative, sustainable, scalable and capable of being evaluated in follow-up studies. Effective training in behaviour change counselling is critical to meet the current and future healthcare needs of patients living with, or at risk of, chronic diseases. Increasing competency in establishing change-based relationships, assessing and promoting readiness to change, implementing behaviour modification and addressing psychosocial issues will be value added to the healthcare system. Copyright © 2017 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.

  2. Integrative Blood Pressure Response to Upright Tilt Post Renal Denervation

    Science.gov (United States)

    Howden, Erin J.; East, Cara; Lawley, Justin S.; Stickford, Abigail S.L.; Verhees, Myrthe; Fu, Qi

    2017-01-01

    Abstract BACKGROUND Whether renal denervation (RDN) in patients with resistant hypertension normalizes blood pressure (BP) regulation in response to routine cardiovascular stimuli such as upright posture is unknown. We conducted an integrative study of BP regulation in patients with resistant hypertension who had received RDN to characterize autonomic circulatory control. METHODS Twelve patients (60 ± 9 [SD] years, n = 10 males) who participated in the Symplicity HTN-3 trial were studied and compared to 2 age-matched normotensive (Norm) and hypertensive (unmedicated, HTN) control groups. BP, heart rate (HR), cardiac output (Qc), muscle sympathetic nerve activity (MSNA), and neurohormonal variables were measured supine, and 30° (5 minutes) and 60° (20 minutes) head-up-tilt (HUT). Total peripheral resistance (TPR) was calculated from mean arterial pressure and Qc. RESULTS Despite treatment with RDN and 4.8 (range, 3–7) antihypertensive medications, the RDN had significantly higher supine systolic BP compared to Norm and HTN (149 ± 15 vs. 118 ± 6, 108 ± 8 mm Hg, P < 0.001). When supine, RDN had higher HR, TPR, MSNA, plasma norepinephrine, and effective arterial elastance compared to Norm. Plasma norepinephrine, Qc, and HR were also higher in the RDN vs. HTN. During HUT, BP remained higher in the RDN, due to increases in Qc, plasma norepinephrine, and aldosterone. CONCLUSION We provide evidence of a possible mechanism by which BP remains elevated post RDN, with the observation of increased Qc and arterial stiffness, as well as plasma norepinephrine and aldosterone levels at approximately 2 years post treatment. These findings may be the consequence of incomplete ablation of sympathetic renal nerves or be related to other factors. PMID:28338768

  3. O papel da odontologia na equipe interdisciplinar: contribuindo para a atenção integral ao idoso

    Directory of Open Access Journals (Sweden)

    Shinkai Rosemary Sadami Arai

    2000-01-01

    Full Text Available Este trabalho bibliográfico teve por objetivo discutir a atuação da odontologia na atenção integral à saúde do idoso, considerando-se a necessidade da abordagem interdisciplinar. É apresentada a atual situação da odontologia geriátrica e os problemas que ocorrem no Brasil pela falta de estudos específicos e de recursos humanos capacitados em geriatria e gerontologia dentro da odontologia. São destacadas as interações entre as diversas profissões de saúde e a odontologia, para a promoção de saúde, prevenção específica e reabilitação de pacientes idosos, com ênfase na importância da comunicação e troca de informações.

  4. O papel da odontologia na equipe interdisciplinar: contribuindo para a atenção integral ao idoso

    Directory of Open Access Journals (Sweden)

    Rosemary Sadami Arai Shinkai

    Full Text Available Este trabalho bibliográfico teve por objetivo discutir a atuação da odontologia na atenção integral à saúde do idoso, considerando-se a necessidade da abordagem interdisciplinar. É apresentada a atual situação da odontologia geriátrica e os problemas que ocorrem no Brasil pela falta de estudos específicos e de recursos humanos capacitados em geriatria e gerontologia dentro da odontologia. São destacadas as interações entre as diversas profissões de saúde e a odontologia, para a promoção de saúde, prevenção específica e reabilitação de pacientes idosos, com ênfase na importância da comunicação e troca de informações.

  5. Iodine and NOx behavior in the dissolver off-gas and IODOX [Iodine Oxidation] systems in the Oak Ridge National Laboratory Integrated Equipment Test facility

    International Nuclear Information System (INIS)

    Birdwell, J.F.

    1990-01-01

    This paper describes the most recent in a series of experiments evaluating the behavior of iodine and NO x in the Integrated Equipment Test (IET) Dissolver Off-Gas (DOG) System. This work was performed as part of a joint collaborative program between the US Department of Energy and the Power and Nuclear Fuel Development Corporation of Japan. The DOG system consists of two shell-and-tube heat exchangers in which water and nitric acid are removed from the dissolver off-gas by condensation, followed by a packed tower in which NO x is removed by absorption into a dilute nitric acid solution. The paper also describes the results of the operation of the Iodine Oxidation (IODOX) System. This system serves to remove iodine from the DOG system effluent by absorption into hyperazeotropic nitric acid. 7 refs., 11 figs., 10 tabs

  6. [Integrity].

    Science.gov (United States)

    Gómez Rodríguez, Rafael Ángel

    2014-01-01

    To say that someone possesses integrity is to claim that that person is almost predictable about responses to specific situations, that he or she can prudentially judge and to act correctly. There is a closed interrelationship between integrity and autonomy, and the autonomy rests on the deeper moral claim of all humans to integrity of the person. Integrity has two senses of significance for medical ethic: one sense refers to the integrity of the person in the bodily, psychosocial and intellectual elements; and in the second sense, the integrity is the virtue. Another facet of integrity of the person is la integrity of values we cherish and espouse. The physician must be a person of integrity if the integrity of the patient is to be safeguarded. The autonomy has reduced the violations in the past, but the character and virtues of the physician are the ultimate safeguard of autonomy of patient. A field very important in medicine is the scientific research. It is the character of the investigator that determines the moral quality of research. The problem arises when legitimate self-interests are replaced by selfish, particularly when human subjects are involved. The final safeguard of moral quality of research is the character and conscience of the investigator. Teaching must be relevant in the scientific field, but the most effective way to teach virtue ethics is through the example of the a respected scientist.

  7. 78 FR 25916 - Authorization of Radiofrequency Equipment

    Science.gov (United States)

    2013-05-03

    ...] Authorization of Radiofrequency Equipment AGENCY: Federal Communications Commission. ACTION: Proposed rule... bodies, and measurement procedures used to determine RF equipment compliance. The Commission believes... Commission is responsible for an equipment authorization program for radiofrequency (RF) devices under part 2...

  8. Integralidade e transdisciplinaridade em equipes multiprofissionais na saúde coletiva Integrality and transdisciplinarity in multi-professional teams in collective health

    Directory of Open Access Journals (Sweden)

    Silvani Botlender Severo

    2010-06-01

    Full Text Available Este artigo traz uma discussão e reflexão sobre a ativação da integralidade no processo de trabalho das equipes multiprofissionais na saúde coletiva. Alicerçamo-nos na teoria da complexidade de Edgar Morin e na lógica transdisciplinar de Basarab Nicolescu para compreender os paradoxos na ação coletiva dos trabalhadores no desafio de integrar as formações disciplinares com a exigência na prática de processos inter/transdisciplinares. Os trabalhadores encontram dificuldades na reorientação do modelo assistencial na saúde quando sua lógica está centrada na doença.This article brings about both a discussion and reflection on the activation of integrality in the work process of multi-professional teams in collective health. It has been grounded on the theory of complexity, by Edgar Morin, as well as on the transdisciplinary logic, by Basarab Nicolescu, to understand paradoxes in the collective action of workers when challenged to integrate disciplinary formations with the practice requirement of inter/transdisciplinary processes. Workers have found difficulty in reorienting the health assisting model whenever their logic is focused on illness.

  9. Design Process for Integrated Concepts with Responsive Building Elements

    DEFF Research Database (Denmark)

    Aa, Van der A.; Heiselberg, Per

    2008-01-01

    An integrated building concept is a prerequisite to come to an energy efficient building with a good and healthy IAQ indoor comfort. A design process that defines the targets and boundary conditions in the very first stage of the design and guarantees them until the building is finished and used...... is needed. The hard question is however: how to make the right choice of the combination of individual measures from building components and building services elements. Within the framework of IEA-ECBCS Annex 44 research has been conducted about the design process for integrated building concepts...

  10. Industry and chain responsibilities and integrative social contract theory

    NARCIS (Netherlands)

    Wempe, J.F.D.B. (Johan)

    2010-01-01

    This article shows that business ethics is not capable of explaining the responsibility of limited organized collectives such as chains, sectors and industries. The responsibility of the pharmaceutical industry to make AIDSblockers available for patients in Africa is an example of such a sector

  11. Assessment of Wind Turbine Structural Integrity using Response Surface Methodology

    DEFF Research Database (Denmark)

    Toft, Henrik Stensgaard; Svenningsen, Lasse; Moser, Wolfgang

    2016-01-01

    Highlights •A new approach to assessment of site specific wind turbine loads is proposed. •The approach can be applied in both fatigue and ultimate limit state. •Two different response surface methodologies have been investigated. •The model uncertainty introduced by the response surfaces...

  12. Optimization of multi-response dynamic systems integrating multiple ...

    African Journals Online (AJOL)

    It also results in better optimization performance than back-propagation neural network-based approach and data mining-based approach reported by the past researchers. Keywords: multiple responses, multiple regression, weighted dynamic signal-to-noise ratio, performance measure modelling, response function ...

  13. Planning and response to Ebola virus disease: An integrated approach.

    Science.gov (United States)

    Smith, Philip W; Boulter, Kathleen C; Hewlett, Angela L; Kratochvil, Christopher J; Beam, Elizabeth J; Gibbs, Shawn G; Lowe, John-Martin J; Schwedhelm, Michelle M

    2015-05-01

    The care of patients with Ebola virus disease (EVD) requires the application of critical care medicine principles under conditions of stringent infection control precautions. The care of patients with EVD requires a number of elements in terms of physical layout, personal protective apparel, and other equipment. Provision of care is demanding in terms of depth of staff and training. The key to safely providing such care is a system that brings many valuable skills to the table, and allows communication between these individuals. We present our approach to leadership structure and function--a variation of incident command--in providing care to 3 patients with EVD. Copyright © 2015 Association for Professionals in Infection Control and Epidemiology, Inc. Published by Elsevier Inc. All rights reserved.

  14. Demonstration of the iodine and NO/sub x/ removal systems in the Oak Ridge National Laboratory integrated equipment test facility

    International Nuclear Information System (INIS)

    Lewis, B.E.; Jubin, R.T.

    1987-03-01

    This report summarizes the findings from three sets of experiments on iodine and NO/sub x/ removal performance using dual downdraft condensers in the dissolver off-gas line. The initial experiments were conducted in the laboratory using glassware in proof-of-principle tests. Two additional sets of condenser experiments were conducted using equipment prototyical for a 0.5-t/d plant in the Integrated Equipment Test (IET) facility at the Oak Ridge National Laboratory. This report also describes the NO/sub x/ removal performance of a packed scrubber in the IET during the dissolution of depleted uranium oxides. The overall iodine pass-through efficiency of the condensers in the IET was high as desired. Removal efficiencies ranged from only 0.35 to 6.29%, indicating that the bulk of the iodine in the off-gas will be transferred on through the condensers to the iodox process for final disposal rather than recycled to the dissolver. The optimum operating temperature for the first condenser was in the range of 50 to 70 0 C, with the temperature of the second condenser held near 20 0 C. The NO/sub x/ removal performance of the combined dual condensers and packed scrubber resulted in effluent off-gas stream NO/sub x/ compositions of ∼0.4 to 1.0%, which are acceptable levels for the iodox process. The NO/sub x/ removal efficiency of the condensers ranged from ∼5 to 58%, but was generally around 20%. The removal efficiency of the packed tower scrubber was observed to be in the range of 40 to 60%. The NO/sub x/ removal performance of the condensers tended to complement the performance of the scrubber in that the condenser removal afficiency was high when the scrubber efficiency was low and vice versa

  15. Boy's responses to the integration of advertising and entertaining content

    NARCIS (Netherlands)

    van Reijmersdal, E.A.; Rozendaal, E.; Buijzen, M.

    2015-01-01

    Purpose - The purposes of this paper are to investigate the effects of integrated advertising formats on the persuasion of children, children’s awareness of the persuasive intent of these formats and how this awareness mediates the level of persuasion. Design/methodology/approach - An one-factor

  16. Boys’ responses to the integration of advertising and entertaining content

    NARCIS (Netherlands)

    Reijmersdal, E.A. van; Rozendaal, E.; Buijzen, M.A.

    2015-01-01

    Purpose – The purposes of this paper are to investigate the effects of integrated advertising formats on the persuasion of children, children’s awareness of the persuasive intent of these formats and how this awareness mediates the level of persuasion. Design/methodology/approach – An one-factor

  17. Taking Responsibility: The integration of Sustainability and Project Management

    NARCIS (Netherlands)

    Jasper van den Brink; Gilbert Gilbert Silvius

    2011-01-01

    Sustainability is one of the most important challenges of our time. How can we develop prosperity, without compromising the life of future generations? Companies are integrating ideas of sustainability in their marketing, corporate communications, annual reports and in their actions. Projects as

  18. The modeling of response indicators of integrated water resources ...

    African Journals Online (AJOL)

    models were used to model and predict the relationship between water resources mobilization WRM and response variables in the ... to the fast growing demand of urban and rural populations ... Meteorological Organization (WMO). They fall.

  19. Optimization of multi-response dynamic systems integrating multiple ...

    African Journals Online (AJOL)

    regression and Taguchi's dynamic signal-to-noise ratio concept ..... algorithm for dynamic multi-response optimization based on goal programming approach. .... problem-solving confirmation, if no grave infringement of model suppositions is ...

  20. The social responsibility of Nanoscience and Nanotechnology: an integral approach

    International Nuclear Information System (INIS)

    Caballero-Díaz, Encarnación; Simonet, Bartolomé M.; Valcárcel, Miguel

    2013-01-01

    The concept of social responsibility provides the ideal framework for raising awareness and arousing reflection on the social and environmental impact of nanoparticles in the range of 1–100 nm generated from research activities in nanoscience and production-related activities in nanotechnology. The model proposed here relates the essential aspects of these concepts by connecting the classical sequence Research–Development–Innovation (R and D and I) to nanoscience and nanotechnology (N and N) and social responsibility (SR). This paper identifies the stakeholders of the process and provides an extensive definition of Social Responsibility and related concepts. In addition, it describes the internal and external connotations of the implementation of SR at research centers and nanotechnological industries, and discusses the social implications of nanoscience and nanotechnology with provision for subjects such as nanoethics, nanotoxicity, and nanomedicine, which have emerged from the widespread use of nanomaterials by today’s society.

  1. The social responsibility of Nanoscience and Nanotechnology: an integral approach

    Science.gov (United States)

    Caballero-Díaz, Encarnación; Simonet, Bartolomé M.; Valcárcel, Miguel

    2013-04-01

    The concept of social responsibility provides the ideal framework for raising awareness and arousing reflection on the social and environmental impact of nanoparticles in the range of 1-100 nm generated from research activities in nanoscience and production-related activities in nanotechnology. The model proposed here relates the essential aspects of these concepts by connecting the classical sequence Research-Development-Innovation (R&D&I) to nanoscience and nanotechnology (N&N) and social responsibility (SR). This paper identifies the stakeholders of the process and provides an extensive definition of Social Responsibility and related concepts. In addition, it describes the internal and external connotations of the implementation of SR at research centers and nanotechnological industries, and discusses the social implications of nanoscience and nanotechnology with provision for subjects such as nanoethics, nanotoxicity, and nanomedicine, which have emerged from the widespread use of nanomaterials by today's society.

  2. The social responsibility of Nanoscience and Nanotechnology: an integral approach

    Energy Technology Data Exchange (ETDEWEB)

    Caballero-Diaz, Encarnacion; Simonet, Bartolome M.; Valcarcel, Miguel, E-mail: qa1vacam@uco.es [University of Cordoba, Department of Analytical Chemistry (Spain)

    2013-04-15

    The concept of social responsibility provides the ideal framework for raising awareness and arousing reflection on the social and environmental impact of nanoparticles in the range of 1-100 nm generated from research activities in nanoscience and production-related activities in nanotechnology. The model proposed here relates the essential aspects of these concepts by connecting the classical sequence Research-Development-Innovation (R and D and I) to nanoscience and nanotechnology (N and N) and social responsibility (SR). This paper identifies the stakeholders of the process and provides an extensive definition of Social Responsibility and related concepts. In addition, it describes the internal and external connotations of the implementation of SR at research centers and nanotechnological industries, and discusses the social implications of nanoscience and nanotechnology with provision for subjects such as nanoethics, nanotoxicity, and nanomedicine, which have emerged from the widespread use of nanomaterials by today's society.

  3. ISO 26000 – An Integrative Approach of Corporate Social Responsibility

    Directory of Open Access Journals (Sweden)

    Herciu Mihaela

    2016-04-01

    Full Text Available ISO 26000 represents a guidance on corporate social responsibility and it is, at the present time, one of the most important document on CSR in the world. Without being mandatory or regulated, ISO 26000 is focus on seven core subjects that have to be approached synergistic – governance, human right, labor, environment, business practices, consumer, and community – in order to achieve its goal. The present paper intends to present and analyze the seven core subjects of ISO 26000 from tow perspectives: by emphasizing the benefits of implementing the standard into the business strategy and by revealing the correlation between corporate social responsibility and sustainable development.

  4. INTEGRATION IN THE CHAIN: A CASE STUDY ON THE COLLABORATION IN THE CHAIN OF A RESALE COMPANY OF PARTS FOR INDUSTRIAL EQUIPMENT

    Directory of Open Access Journals (Sweden)

    Inês Shinobu Chubachi

    2016-07-01

    Full Text Available The increasing market competition makes companies seek better results, through partnerships with suppliers, and it isnecessary to analyze and adapt to the requirements of customers and market. Thus, for the realization of this article, it is based on concepts of Logistics according to supply chain, intending to analyze operational processes and suggest improvements in results and competitive gains for collaboration in the chain of trade in pieces of industrial equipment company in the Greater São Paulo region. Therefore, we conducted literature searches through books and articles, as well as a case study, which in general, revealed that the supply chain of the studied company has great potential for improvement it once has modest integration actions compared to a model with a strategic focus and some deviations compared to the academic literature. Research results have shown issues such as ignorance of the subject proposed by the employees as well as the need to create alternatives to maximize the interaction between the sectors within the organization contributing more competitive solutions in addition to providing agility in the process as a whole. To carry out further research, it is recommended further study regarding the implementation of management information systems to improve some processes and, consequently, the outcome of that organization.

  5. Integration of gamma measuring equipment into an Agusta A109BA helicopter of the Belgian Armed Forces for use in emergency situations

    International Nuclear Information System (INIS)

    Paridaens, J.

    2007-01-01

    In case of a nuclear emergency, accidental releases of radioactive material might cause large scale environmental contamination. After the emergency has been brought under control, and the radioactive releases have settled on the ground, it is essential to map as quickly as possible the extent of the contaminated area and to evaluate the severity of the contamination. Airborne gamma measurements are known to be an effective means for quickly and safely mapping and evaluating large scale contaminations of gamma-emitting radio nuclides. We wanted to integrate gamma measuring equipment, based on a NaI detector, into an Agusta A109BA helicopter of the Belgian armed forces. This was done within the framework of ''Aid to the Nation'', a special program developed by the Belgian Armed Forces for facilitating cooperation between the armed forces and civilian organisations, for projects that are to the benefit of the Belgian Nation. Working in this framework, we also want to develop the necessary procedures that will allow quick and efficient deployment of the measuring capability in case of an emergency

  6. Equipment stainless steel entire versus steels bimetallics clad or overlay; Utilizacao de equipamentos de processo construidos em aco inoxidavel integral versus acos bimetalicos cladeado ou 'overlay'

    Energy Technology Data Exchange (ETDEWEB)

    Batista, Itamar da Silva; Lima, Jadival Carneiro de; Leal, Murilo Fonseca; Cardoso, Amauri dos Santos; Jorjan, Roberto [PETROBRAS S.A., Sao Francisco do Conde, BA (Brazil). Refinaria Landulfo Alves Mataripen (RLAM)

    2008-07-01

    This study does not recommend the use of a pressure vessel made of integral stainless steel, due to the failure mechanisms under stress corrosion assisted by chlorides or polythionic acid. Are presented case studies of literature and analysis of reports of proceedings of RLAM reactors, showing that the materials produced by bimetallic clad overlay or are more appropriate, in terms of integrity, for use in equipment that the internal environment requires austenitic stainless steel specification.

  7. Guidelines for integrating socially responsible investment in the investment process

    NARCIS (Netherlands)

    de Graaf, F.J.; Slager, A.

    2009-01-01

    Socially Responsible Investment (SRI) is of growing importance for institutional investors. Our analysis shows that SRI strategies can be grouped in ethically-based, investment-driven and value-ensuring objectives. We demonstrate that this categorization strengthens decisionmaking in SRI. Based on

  8. The integration of corporate governance in corporate social responsibility disclosures

    NARCIS (Netherlands)

    Kolk, A.; Pinkse, J.

    2010-01-01

    In recent years, not only has attention to corporate governance increased but also the notion has broadened considerably, and started to cover some aspects traditionally seen as being part of corporate social responsibility (CSR). CSR, corporate governance and their interlink seem particularly

  9. The modeling of response indicators of integrated water resources ...

    African Journals Online (AJOL)

    The results indicate that the feed forward multilayer perceptron models with back propagation are useful tools to define and prioritize the most effective response variable on water resources mobilization to intervene and solve water problems. The model evaluation shows that the correlation coefficients are more than 96% ...

  10. A tool to guide the process of integrating health system responses to public health problems

    Directory of Open Access Journals (Sweden)

    Tilahun Nigatu Haregu

    2015-06-01

    Full Text Available An integrated model of health system responses to public health problems is considered to be the most preferable approach. Accordingly, there are several models that stipulate what an integrated architecture should look like. However, tools that can guide the overall process of integration are lacking. This tool is designed to guide the entire process of integration of health system responses to major public health problems. It is developed by taking into account the contexts of health systems of developing countries and the emergence of double-burden of chronic diseases in these settings. Chronic diseases – HIV/AIDS and NCDs – represented the evidence base for the development of the model. System level horizontal integration of health system responses were considered in the development of this tool.

  11. High-speed railway signal trackside equipment patrol inspection system

    Science.gov (United States)

    Wu, Nan

    2018-03-01

    High-speed railway signal trackside equipment patrol inspection system comprehensively applies TDI (time delay integration), high-speed and highly responsive CMOS architecture, low illumination photosensitive technique, image data compression technique, machine vision technique and so on, installed on high-speed railway inspection train, and achieves the collection, management and analysis of the images of signal trackside equipment appearance while the train is running. The system will automatically filter out the signal trackside equipment images from a large number of the background image, and identify of the equipment changes by comparing the original image data. Combining with ledger data and train location information, the system accurately locate the trackside equipment, conscientiously guiding maintenance.

  12. Regulatory Guide 1.122: Development of floor design response spectra for seismic design of floor-supported equipment or components

    International Nuclear Information System (INIS)

    Anon.

    1993-01-01

    ''Reactor Site Criteria,'' requires, in part, that safety-related structures, systems, and components remain functional in the event of a Safe Shutdown Earthquake (SSE). It specifies the use of a suitable dynamic analysis as one method of ensuring that the structures, systems, and components can withstand the seismic loads. Similarly, paragraph (a)(2) of Section VI of the same appendix requires, in part, that the structures, systems, and components necessary for continued operation without undue risk to the health and safety of the public remain functional in the event of an Operating Basis Earthquake (OBE). Again, the use of suitable dynamic analysis is specified as one method of ensuring that the structures, systems, and components can withstand the seismic loads. This guide describes methods acceptable to the NRC staff for developing two horizontal and one vertical floor design response spectra at various floors or other equipment-support locations of interest from the time-history motions resulting from the dynamic analysis of the supporting structure. These floor design response spectra are needed for the dynamic analysis of the systems or equipment supported at various locations of the supporting structure

  13. Integrated Platform for Automated Sustainable Demand Response in Smart Grids

    Energy Technology Data Exchange (ETDEWEB)

    Zois, Vassilis [Univ. of Southern California, Los Angeles, CA (United States). Dept. of Computer Science; Frincu, Marc [Univ. of Southern California, Los Angeles, CA (United States). Dept. of Electrical Engineering; Prasanna, Viktor K. [Univ. of Southern California, Los Angeles, CA (United States). Dept. of Electrical Engineering

    2014-10-08

    Demand Response(DR) is a common practice used by utility providers to regulate energy demand. It is used at periods of high demand to minimize the peak to average consumption ratio. Several methods have been Demand Response(DR) is a common praon using information about the baseline consumption and the consumption during DR. Our goal is to provide a sustainable reduction to ensure the elimination of peaks in demand. The proposed system includes an adaptation mechanism for when the provided solution does not meet the DR requirements. We conducted a series of experiments using consumption data from a real life micro grid to evaluate the efficiency as well as the robustness of our solution.

  14. Measuring Integration of Information and Communication Technology in Education: An Item Response Modeling Approach

    Science.gov (United States)

    Peeraer, Jef; Van Petegem, Peter

    2012-01-01

    This research describes the development and validation of an instrument to measure integration of Information and Communication Technology (ICT) in education. After literature research on definitions of integration of ICT in education, a comparison is made between the classical test theory and the item response modeling approach for the…

  15. The paradigm of consumer-driven and responsive supply chains: An integrated project approach

    NARCIS (Netherlands)

    Zimmermann, K.L.; Lans, van der I.A.

    2009-01-01

    This paper describes an integrated project approach that forms the basis of the studies on consumer-driven innovative and responsive supply chains in ISAFRUIT Pillar 1. This integrated approach leads to a wide range of indepth results on trends, preferences, and innovativeness of the European

  16. Pre-Service Teachers' Perception of Quick Response (QR) Code Integration in Classroom Activities

    Science.gov (United States)

    Ali, Nagla; Santos, Ieda M.; Areepattamannil, Shaljan

    2017-01-01

    Quick Response (QR) codes have been discussed in the literature as adding value to teaching and learning. Despite their potential in education, more research is needed to inform practice and advance knowledge in this field. This paper investigated the integration of the QR code in classroom activities and the perceptions of the integration by…

  17. Cost analysis of an integrated disease surveillance and response system: case of Burkina Faso, Eritrea, and Mali.

    Science.gov (United States)

    Somda, Zana C; Meltzer, Martin I; Perry, Helen N; Messonnier, Nancy E; Abdulmumini, Usman; Mebrahtu, Goitom; Sacko, Massambou; Touré, Kandioura; Ki, Salimata Ouédraogo; Okorosobo, Tuoyo; Alemu, Wondimagegnehu; Sow, Idrissa

    2009-01-08

    Communicable diseases are the leading causes of illness, deaths, and disability in sub-Saharan Africa. To address these threats, countries within the World Health Organization (WHO) African region adopted a regional strategy called Integrated Disease Surveillance and Response (IDSR). This strategy calls for streamlining resources, tools, and approaches to better detect and respond to the region's priority communicable disease. The purpose of this study was to analyze the incremental costs of establishing and subsequently operating activities for detection and response to the priority diseases under the IDSR. We collected cost data for IDSR activities at central, regional, district, and primary health care center levels from Burkina Faso, Eritrea, and Mali, countries where IDSR is being fully implemented. These cost data included personnel, transportation items, office consumable goods, media campaigns, laboratory and response materials and supplies, and annual depreciation of buildings, equipment, and vehicles. Over the period studied (2002-2005), the average cost to implement the IDSR program in Eritrea was $0.16 per capita, $0.04 in Burkina Faso and $0.02 in Mali. In each country, the mean annual cost of IDSR was dependent on the health structure level, ranging from $35,899 to $69,920 at the region level, $10,790 to $13,941 at the district level, and $1,181 to $1,240 at the primary health care center level. The proportions spent on each IDSR activity varied due to demand for special items (e.g., equipment, supplies, drugs and vaccines), service availability, distance, and the epidemiological profile of the country. This study demonstrates that the IDSR strategy can be considered a low cost public health system although the benefits have yet to be quantified. These data can also be used in future studies of the cost-effectiveness of IDSR.

  18. Cost analysis of an integrated disease surveillance and response system: case of Burkina Faso, Eritrea, and Mali

    Directory of Open Access Journals (Sweden)

    Touré Kandioura

    2009-01-01

    Full Text Available Abstract Background Communicable diseases are the leading causes of illness, deaths, and disability in sub-Saharan Africa. To address these threats, countries within the World Health Organization (WHO African region adopted a regional strategy called Integrated Disease Surveillance and Response (IDSR. This strategy calls for streamlining resources, tools, and approaches to better detect and respond to the region's priority communicable disease. The purpose of this study was to analyze the incremental costs of establishing and subsequently operating activities for detection and response to the priority diseases under the IDSR. Methods We collected cost data for IDSR activities at central, regional, district, and primary health care center levels from Burkina Faso, Eritrea, and Mali, countries where IDSR is being fully implemented. These cost data included personnel, transportation items, office consumable goods, media campaigns, laboratory and response materials and supplies, and annual depreciation of buildings, equipment, and vehicles. Results Over the period studied (2002–2005, the average cost to implement the IDSR program in Eritrea was $0.16 per capita, $0.04 in Burkina Faso and $0.02 in Mali. In each country, the mean annual cost of IDSR was dependent on the health structure level, ranging from $35,899 to $69,920 at the region level, $10,790 to $13,941 at the district level, and $1,181 to $1,240 at the primary health care center level. The proportions spent on each IDSR activity varied due to demand for special items (e.g., equipment, supplies, drugs and vaccines, service availability, distance, and the epidemiological profile of the country. Conclusion This study demonstrates that the IDSR strategy can be considered a low cost public health system although the benefits have yet to be quantified. These data can also be used in future studies of the cost-effectiveness of IDSR.

  19. Strategic Demand-Side Response to Wind Power Integration

    DEFF Research Database (Denmark)

    Daraeepour, Ali; Kazempour, Seyyedjalal; Patiño-Echeverri, Dalia

    2016-01-01

    This paper explores the effects of allowing large, price-responsive consumers to provide reserves in a power system with significant penetration of wind energy. A bilevel optimization model represents the utility maximization problem of a large consumer, subject to a stochastic day-ahead co......-optimization of energy and reserves that a system operator would solve to clear the market while considering wind power uncertainty. An examination of the market outcomes from both an illustrative and a large-scale study using this model allows analysis of a) the effects of the type of behavior of the large consumer (i...

  20. Equipping tomorrow's fire manager

    Science.gov (United States)

    Christopher A. Dicus

    2008-01-01

    Fire managers are challenged with an ever-increasing array of both responsibilities and critics. As in the past, fire managers must master the elements of fire behavior and ecology using the latest technologies. In addition, today’s managers must be equipped with the skills necessary to understand and liaise with a burgeoning group of vocal stakeholders while also...

  1. Integrated genomics of ovarian xenograft tumor progression and chemotherapy response

    International Nuclear Information System (INIS)

    Stuckey, Ashley; Brodsky, Alexander S; Fischer, Andrew; Miller, Daniel H; Hillenmeyer, Sara; Kim, Kyu K; Ritz, Anna; Singh, Rakesh K; Raphael, Benjamin J; Brard, Laurent

    2011-01-01

    Ovarian cancer is the most deadly gynecological cancer with a very poor prognosis. Xenograft mouse models have proven to be one very useful tool in testing candidate therapeutic agents and gene function in vivo. In this study we identify genes and gene networks important for the efficacy of a pre-clinical anti-tumor therapeutic, MT19c. In order to understand how ovarian xenograft tumors may be growing and responding to anti-tumor therapeutics, we used genome-wide mRNA expression and DNA copy number measurements to identify key genes and pathways that may be critical for SKOV-3 xenograft tumor progression. We compared SKOV-3 xenografts treated with the ergocalciferol derived, MT19c, to untreated tumors collected at multiple time points. Cell viability assays were used to test the function of the PPARγ agonist, Rosiglitazone, on SKOV-3 cell growth. These data indicate that a number of known survival and growth pathways including Notch signaling and general apoptosis factors are differentially expressed in treated vs. untreated xenografts. As tumors grow, cell cycle and DNA replication genes show increased expression, consistent with faster growth. The steroid nuclear receptor, PPARγ, was significantly up-regulated in MT19c treated xenografts. Surprisingly, stimulation of PPARγ with Rosiglitazone reduced the efficacy of MT19c and cisplatin suggesting that PPARγ is regulating a survival pathway in SKOV-3 cells. To identify which genes may be important for tumor growth and treatment response, we observed that MT19c down-regulates some high copy number genes and stimulates expression of some low copy number genes suggesting that these genes are particularly important for SKOV-3 xenograft growth and survival. We have characterized the time dependent responses of ovarian xenograft tumors to the vitamin D analog, MT19c. Our results suggest that PPARγ promotes survival for some ovarian tumor cells. We propose that a combination of regulated expression and copy number

  2. The intracellular cholesterol landscape: dynamic integrator of the immune response

    Science.gov (United States)

    Fessler, Michael B.

    2016-01-01

    Cholesterol has typically been considered an exogenous, disease-related factor in immunity; however, recent literature suggests that a paradigm shift is in order. Sterols are now recognized to ligate several immune receptors. Altered flux through the mevalonic acid synthesis pathway also appears to be a required event in the antiviral interferon response of macrophages and in the activation, proliferation, and differentiation of T cells. In this review, evidence is discussed that suggests an intrinsic, ‘professional’ role for sterols and oxysterols in macrophage and T cell immunity. Host defense may have been the original selection pressure behind the development of mechanisms for intracellular cholesterol homeostasis. Functional coupling between sterol metabolism and immunity has fundamental implications for health and disease. PMID:27692616

  3. [Hydrotherapy equipment].

    Science.gov (United States)

    Tsibikov, V B; Ragozin, S I; Mikheeva, L V

    1985-01-01

    A flow-chart is developed demonstrating the relation between medical and prophylactic institutions within the organizational structure of the rehabilitation system and main types of rehabilitation procedures. In order to ascertain the priority in equipping rehabilitation services with adequate hardware the special priority criterion is introduced. The highest priority is assigned to balneotherapeutic and fangotherapeutic services. Based on the operation-by-operation analysis of clinical processes related to service and performance of balneologic procedures the preliminary set of clinical devices designed for baths, basins and showers in hospitals and rehabilitation departments is defined in a generalized form.

  4. Experience of high-nitrogenous steel powder application in repairs and surface hardening of responsible parts for power equipment by plasma spraying

    Science.gov (United States)

    Kolpakov, A. S.; Kardonina, N. I.

    2016-02-01

    The questions of the application of novel diffusion-alloying high-nitrogenous steel powders for repair and surface hardening of responsible parts of power equipment by plasma spraying are considered. The appropriateness of the method for operative repair of equipment and increasing its service life is justified. General data on the structure, properties, and manufacture of nitrogen-, aluminum-, and chromium-containing steel powders that are economically alloyed using diffusion are described. It is noted that the nitrogen release during the decomposition of iron nitrides, when heating, protects the powder particles from oxidation in the plasma jet. It is shown that the coating retains 50% of nitrogen that is contained in the powder. Plasma spraying modes for diffusion-alloying high-nitrogenous steel powders are given. The service properties of plasma coatings based on these powders are analyzed. It is shown that the high-nitrogenous steel powders to a nitrogen content of 8.9 wt % provide the necessary wear resistance and hardness of the coating and the strength of its adhesion to the substrate and corrosion resistance to typical aggressive media. It is noted that increasing the coating porosity promotes stress relaxation and increases its thickness being limited with respect to delamination conditions in comparison with dense coatings on retention of the low defectiveness of the interface and high adhesion to the substrate. The examples of the application of high-nitrogenous steel powders in power engineering during equipment repairs by service companies and overhaul subdivisions of heat power plants are given. It is noted that the plasma spraying of diffusion-alloyed high-nitrogenous steel powders is a unique opportunity to restore nitrided steel products.

  5. The integration of corporate social responsibility (CSR) initiatives into business activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    2013-01-01

    While proponents of corporate social responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as 'strategic CSR' or 'shared value', research is lacking that explores how CSR programmes are integrated in companies. This paper compares CSR...... initiatives with human resource management (HRM) activities, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities. In contrast, the MNC...

  6. The Integration of Corporate Social Responsibility (CSR) Initiatives into Business Activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    While proponents of Corporate Social Responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as ‘strategic CSR’ or ‘shared value’, research is lacking that explores how CSR initiatives are integrated in companies. This article compares CSR...... initiatives to human resource management (HRM) initiatives, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR initiatives in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities...

  7. Demonstration of the iodine and NO/sub x/ removal systems in the Oak Ridge National Laboratory (ORNL) Integrated Equipment Test (IET) facility

    International Nuclear Information System (INIS)

    Jubin, R.T.; Lewis, B.E.

    1986-01-01

    The overall iodine removal performance of the condensers during phase-two experiments was good (i.e., very small amounts of iodine were recycled), with removal efficiency for both condensers ranging from 0.35 to 6.29%. The removal efficiency for the first condenser ranged from 0.03 to 5.78%, and the second condenser, from 0.02 to 3.42%. In all the cases studied, the overall iodine removal efficiency appeared to be smallest, with the first condenser operating near 50 0 C. While the 50 0 C operating temperature is not necessarily the optimum temperature, the data appear to indicate that the optimum is bounded by 50 and 70 0 C. Phase three of the Integrated Equipment Test dissolver off-gas (DOG) system tests verified the operation of the dual condensers and the NO/sub x/ scrubber column under a variety of operating conditions. The removal efficiencies of the condensers were higher than anticipated, generally approx.20% in these tests. The scrubber provided an NO/sub x/ effluent of approx.0.4 to 1.0% during the entire campaign, which is consistent with the acceptable NO/sub x/ levels in the off-gas to Iodox. In addition, this 0.4-to-1.0% NO/sub x/ level in the scrubber effluent confirms the BRET design decision to omit the NO/sub x/ scrubber in a system with a DOG NO/sub x/ concentration of approx.1.0%

  8. On-line coupling of a microelectrode array equipped poly(dimethylsiloxane) microchip with an integrated graphite electrospray emitter for electrospray ionisation mass spectrometry.

    Science.gov (United States)

    Liljegren, Gustav; Dahlin, Andreas; Zettersten, Camilla; Bergquist, Jonas; Nyholm, Leif

    2005-10-01

    A novel method for the manufacturing of microchips for on-chip combinations of electrochemistry (EC) and sheathless electrospray ionisation mass spectrometry (ESI-MS) is described. The technique, which does not require access to clean-room facilities, is based on the incorporation of an array of gold microcoil electrodes into a poly(dimethylsiloxane)(PDMS) microflow channel equipped with an integrated graphite based sheathless ESI emitter. Electrochemical measurements, which were employed to determine the electroactive area of the electrodes and to test the microchips, show that the manufacturing process was reproducible and that the important interelectrode distance in the electrochemical cell could to be adequately controlled. The EC-ESI-MS device was evaluated based on the ESI-MS detection of the oxidation products of dopamine. The results demonstrate that the present on-chip approach enables full potentiostatic control of the electrochemical cell and the attainment of very short transfer times between the electrochemical cell and the electrospray emitter. The transfer times were 0.6 and 1.2 s for flow rates of 1.0 and 0.5 microL min(-1), respectively, while the electrochemical conversion efficiency of the electrochemical cell was found to be 30% at a flow rate of 0.5 microL min(-1). To decouple the electrochemical cell from the ESI-MS high voltage and to increase the user-friendliness, the on-line electrochemistry-ESI-MS experiments were performed using a wireless Bluetooth battery-powered instrument with the chip floating at the potential induced by the ESI high voltage. The described on-chip EC-ESI-MS device can be used for fundamental electrochemical investigations as well as for applications based on the use of electrochemically controlled sample pretreatment, preconcentration and ionisation steps prior to ESI-MS.

  9. Reasons Not to Cheat, Academic-Integrity Responsibility, and Frequency of Cheating

    Science.gov (United States)

    Miller, Arden; Shoptaugh, Carol; Wooldridge, Jessica

    2011-01-01

    The authors investigated the relations among reasons students gave for why they would not cheat in response to a cheating vignette, self-reported cheating, and the extent to which students take responsibility for promoting academic integrity. The authors surveyed 1,086 graduate and undergraduate students. Students who said they would not cheat…

  10. The integrity of the tax system after BEPS : A shared responsibility

    NARCIS (Netherlands)

    Gribnau, Hans

    2017-01-01

    The international tax system is the result of the interaction of different actors who share the responsibility for its integrity. States and multinational corporations both enjoy to a certain extent freedom of choice with regard to their tax behaviour – which entails moral responsibility. Making,

  11. Dynamic Response of Control Servo System Installed in NAES-Equipped SB2C-5 Airplane (BuAer No. 83135)

    Science.gov (United States)

    Smaus, Louis H.; Stewart, Elwood C.

    1950-01-01

    Dynamic--response measurements for various conditions of displacement and rate signal input, sensitivity setting, and simulated hinge moment were made of the three control-surface servo systems of an NAES-equipped remote-controlled airplane while on the ground. The basic components of the servo systems are those of the General Electric Company type G-1 autopilot using electrical signal. sources, solenoid-operated valves, and hydraulic pistons. The test procedures and difficulties are discussed, Both frequency and transient-response data, are presented and comparisons are made. The constants describing the servo system, the undamped natural frequency, and the damping ratio, are determined by several methods. The response of the system with the addition of airframe rate signal is calculated. The transfer function of the elevator surface, linkage, and cable system is obtained. The agreement between various methods of measurement and calculation is considered very good. The data are complete enough and in such form that they may be used directly with the frequency-response data of an airplane to predict the stability of the autopilot-airplane combination.

  12. The development of a fully-integrated immune response model (FIRM) simulator of the immune response through integration of multiple subset models.

    Science.gov (United States)

    Palsson, Sirus; Hickling, Timothy P; Bradshaw-Pierce, Erica L; Zager, Michael; Jooss, Karin; O'Brien, Peter J; Spilker, Mary E; Palsson, Bernhard O; Vicini, Paolo

    2013-09-28

    The complexity and multiscale nature of the mammalian immune response provides an excellent test bed for the potential of mathematical modeling and simulation to facilitate mechanistic understanding. Historically, mathematical models of the immune response focused on subsets of the immune system and/or specific aspects of the response. Mathematical models have been developed for the humoral side of the immune response, or for the cellular side, or for cytokine kinetics, but rarely have they been proposed to encompass the overall system complexity. We propose here a framework for integration of subset models, based on a system biology approach. A dynamic simulator, the Fully-integrated Immune Response Model (FIRM), was built in a stepwise fashion by integrating published subset models and adding novel features. The approach used to build the model includes the formulation of the network of interacting species and the subsequent introduction of rate laws to describe each biological process. The resulting model represents a multi-organ structure, comprised of the target organ where the immune response takes place, circulating blood, lymphoid T, and lymphoid B tissue. The cell types accounted for include macrophages, a few T-cell lineages (cytotoxic, regulatory, helper 1, and helper 2), and B-cell activation to plasma cells. Four different cytokines were accounted for: IFN-γ, IL-4, IL-10 and IL-12. In addition, generic inflammatory signals are used to represent the kinetics of IL-1, IL-2, and TGF-β. Cell recruitment, differentiation, replication, apoptosis and migration are described as appropriate for the different cell types. The model is a hybrid structure containing information from several mammalian species. The structure of the network was built to be physiologically and biochemically consistent. Rate laws for all the cellular fate processes, growth factor production rates and half-lives, together with antibody production rates and half-lives, are provided. The

  13. UTILIZING SAR AND MULTISPECTRAL INTEGRATED DATA FOR EMERGENCY RESPONSE

    Directory of Open Access Journals (Sweden)

    S. Havivi

    2016-06-01

    complete scene for the emergency response following an event.

  14. Evaluation of time integration methods for transient response analysis of nonlinear structures

    International Nuclear Information System (INIS)

    Park, K.C.

    1975-01-01

    Recent developments in the evaluation of direct time integration methods for the transient response analysis of nonlinear structures are presented. These developments, which are based on local stability considerations of an integrator, show that the interaction between temporal step size and nonlinearities of structural systems has a pronounced effect on both accuracy and stability of a given time integration method. The resulting evaluation technique is applied to a model nonlinear problem, in order to: 1) demonstrate that it eliminates the present costly process of evaluating time integrator for nonlinear structural systems via extensive numerical experiments; 2) identify the desirable characteristics of time integration methods for nonlinear structural problems; 3) develop improved stiffly-stable methods for application to nonlinear structures. Extension of the methodology for examination of the interaction between a time integrator and the approximate treatment of nonlinearities (such as due to pseudo-force or incremental solution procedures) is also discussed. (Auth.)

  15. Autonomous Preference-Aware Information Services Integration for High Response in Integrated Faded Information Field Systems

    Science.gov (United States)

    Lu, Xiaodong; Mori, Kinji

    The market and users' requirements have been rapidly changing and diversified. Under these heterogeneous and dynamic situations, not only the system structure itself, but also the accessible information services would be changed constantly. To cope with the continuously changing conditions of service provision and utilization, Faded Information Field (FIF) has been proposed, which is a agent-based distributed information service system architecture. In the case of a mono-service request, the system is designed to improve users' access time and preserve load balancing through the information structure. However, with interdependent requests of multi-service increasing, adaptability and timeliness have to be assured by the system. In this paper, the relationship that exists among the correlated services and the users' preferences for separate and integrated services is clarified. Based on these factors, the autonomous preference-aware information services integration technology to provide one-stop service for users multi-service requests is proposed. As compared to the conventional system, we show that proposed technology is able to reduce the total access time.

  16. Responses to GM food content in context with food integrity issues: results from Australian population surveys.

    Science.gov (United States)

    Mohr, Philip; Golley, Sinéad

    2016-01-25

    This study examined community responses to use of genetically modified (GM) content in food in the context of responses to familiar food additives by testing an empirically and theoretically derived model of the predictors of responses to both GM content and food integrity issues generally. A nationwide sample of 849 adults, selected at random from the Australian Electoral Roll, responded to a postal Food and Health Survey. Structural equation modelling analyses confirmed that ratings of general concern about food integrity (related to the presence of preservatives and other additives) strongly predicted negativity towards GM content. Concern about food integrity was, in turn, predicted by environmental concern and health engagement. In addition, both concern about food integrity generally and responses to GM content specifically were weakly predicted by attitudes to benefits of science and an intuitive (i.e., emotionally-based) reasoning style. Data from a follow-up survey conducted under the same conditions (N=1184) revealed that ratings of concern were significantly lower for use of genetic engineering in food than for four other common food integrity issues examined. Whereas the question of community responses to GM is often treated as a special issue, these findings support the conclusion that responses to the concept of GM content in food in Australia are substantially a specific instance of a general sensitivity towards the integrity of the food supply. They indicate that the origins of responses to GM content may be largely indistinguishable from those of general responses to preservatives and other common food additives. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. Seismic response of reactor building on alluvial soil by direct implicit integration

    International Nuclear Information System (INIS)

    Thakkar, S.K.; Dinkar, A.K.

    1983-01-01

    The evaluation of seismic response of a reactor building is a complex problem. A study has been made in this paper of seismic response of a reactor building by direct implicit integration method. The direct implicit integration methods besides being unconditionally stable have the merit of including response of higher modes without much effort. A reactor building consisting of external shell, internal shell, internals and raft is considered to be resting on alluvium. The complete building including the foundation is idealized by axisymmetric finite elements. The structure is analyzed separately for horizontal and vertical components of ground motion using harmonic analysis. Total response is found by superposition of two responses. The variation of several parameters, such as soil stiffness, embedment depth, inertia of foundation, viscous boundary and damping on seismic response is studied. The structural response is seen to depend significantly on the soil stiffness and damping. The seismic response is observed to be less sensitive to embedment depth and inertia of foundation. The vertical accelerations on the raft, boiler room floor slab and dome due to vertical ground motions are quite appreciable. The viscous boundary is seen to alter structural response in significantly compared to rigid boundaries in a larger mesh and its use appears to be promising in absorbing energy of body waves when used with direct implicit integration method. (orig.)

  18. Responses of sun-induced chlorophyll fluorescence to biological and environmental variations measured with a versatile Fluorescence Auto-Measurement Equipment (FAME)

    Science.gov (United States)

    Gu, L.

    2017-12-01

    In this study, we examine responses of sun-induced chlorophyll fluorescence to biological and environmental variations measured with a versatile Fluorescence Auto-Measurement Equipment (FAME). FAME was developed to automatically and continuously measure chlorophyll fluorescence (F) of a leaf, plant or canopy in both laboratory and field environments, excited by either artificial light source or sunlight. FAME is controlled by a datalogger and allows simultaneous measurements of environmental variables complementary to the F signals. A built-in communication system allows FAME to be remotely monitored and data-downloaded. Radiance and irradiance calibrations can be done online. FAME has been applied in a variety of environments, allowing an investigation of biological and environmental controls on F emission.

  19. Report on the emergency response training and equipment activities through 1991 for the transportation of transuranic waste to the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    1992-04-01

    The Waste Isolation Pilot Plant (WIPP) is a research and development facility with the mission of demonstrating the safe shipment, emplacement and retrieval of radioactive transuranic (TRU) wastes resulting from the defense activities and programs of the United States. It is the only long-term storage facility constructed for TRU waste. This report provides the status on the Department of Energy (DOE) efforts as of December 31, 1991, regarding emergency response training and equipment funding provided to local, state, and tribal governments for waste shipments to the WIPP. Because of a growing public awareness of transportation activities involving nuclear materials, this report has been prepared to provide a status of the DOE's activities in this regard, as well as the cooperative efforts between the DOE and state and tribal governments

  20. Cryogenic equipment

    International Nuclear Information System (INIS)

    Leger, L.; Javellaud, J.; Caro, C.; Gilguy, R.; Testard, O.

    1966-06-01

    The cryostats presented here were built from standard parts; this makes it possible to construct a great variety of apparatus at minimum cost. The liquid nitrogen and helium reservoirs were designed so as to reduce losses to a minimum, and so as to make the cryostats as autonomous as possible. The experimental enclosure which is generally placed in the lower part of the apparatus requires a separate study in every case. Furthermore, complete assemblies such as transfer rods, isolated traps and high vacuum valves, were designed with a similar regard for the economic aspects and for the need for standardization. This equipment thus satisfies a great variety of experimental needs; it is readily adaptable and the consumptions of helium and liquid nitrogen are very low. (authors) [fr

  1. Free-world microelectronic manufacturing equipment

    Science.gov (United States)

    Kilby, J. S.; Arnold, W. H.; Booth, W. T.; Cunningham, J. A.; Hutcheson, J. D.; Owen, R. W.; Runyan, W. R.; McKenney, Barbara L.; McGrain, Moira; Taub, Renee G.

    1988-12-01

    Equipment is examined and evaluated for the manufacture of microelectronic integrated circuit devices and sources for that equipment within the Free World. Equipment suitable for the following are examined: single-crystal silicon slice manufacturing and processing; required lithographic processes; wafer processing; device packaging; and test of digital integrated circuits. Availability of the equipment is also discussed, now and in the near future. Very adequate equipment for most stages of the integrated circuit manufacturing process is available from several sources, in different countries, although the best and most widely used versions of most manufacturing equipment are made in the United States or Japan. There is also an active market in used equipment, suitable for manufacture of capable integrated circuits with performance somewhat short of the present state of the art.

  2. Dissecting stimulus-response binding effects: Grouping by color separately impacts integration and retrieval processes.

    Science.gov (United States)

    Laub, Ruth; Frings, Christian; Moeller, Birte

    2018-04-23

    In selection tasks, target and distractor features can be encoded together with the response into the same short-lived memory trace, or event file (see Hommel, 2004), leading to bindings between stimulus and response features. The repetition of a stored target or distractor feature can lead to the retrieval of the entire episode, including the response-so-called "binding effects." Binding effects due to distractor repetition are stronger for grouped than for nongrouped target and distractor stimulus configurations. Modulation of either of two mechanisms that lead to the observed binding effects might be responsible here: Grouping may influence either stimulus-response integration or stimulus-response retrieval. In the present study we investigated the influences of grouping on both mechanisms independently. In two experiments, target and distractor letters were grouped (or nongrouped) via color (dis)similarity separately during integration and retrieval. Grouping by color similarity affected integration and retrieval mechanisms independently and in different ways. Color dissimilarity enhanced distractor-based retrieval, whereas color similarity enhanced distractor integration. We concluded that stimulus grouping is relevant for binding effects, but that the mechanisms that contribute to binding effects should be carefully separated.

  3. HPV Integration in HNSCC Correlates with Survival Outcomes, Immune Response Signatures, and Candidate Drivers.

    Science.gov (United States)

    Koneva, Lada A; Zhang, Yanxiao; Virani, Shama; Hall, Pelle B; McHugh, Jonathan B; Chepeha, Douglas B; Wolf, Gregory T; Carey, Thomas E; Rozek, Laura S; Sartor, Maureen A

    2018-01-01

    The incidence of human papillomavirus (HPV)-related oropharynx cancer has steadily increased over the past two decades and now represents a majority of oropharyngeal cancer cases. Integration of the HPV genome into the host genome is a common event during carcinogenesis that has clinically relevant effects if the viral early genes are transcribed. Understanding the impact of HPV integration on clinical outcomes of head and neck squamous cell carcinoma (HNSCC) is critical for implementing deescalated treatment approaches for HPV + HNSCC patients. RNA sequencing (RNA-seq) data from HNSCC tumors ( n = 84) were used to identify and characterize expressed integration events, which were overrepresented near known head and neck, lung, and urogenital cancer genes. Five genes were recurrent, including CD274 (PD-L1) A significant number of genes detected to have integration events were found to interact with Tp63, ETS, and/or FOX1A. Patients with no detected integration had better survival than integration-positive and HPV - patients. Furthermore, integration-negative tumors were characterized by strongly heightened signatures for immune cells, including CD4 + , CD3 + , regulatory, CD8 + T cells, NK cells, and B cells, compared with integration-positive tumors. Finally, genes with elevated expression in integration-negative specimens were strongly enriched with immune-related gene ontology terms, while upregulated genes in integration-positive tumors were enriched for keratinization, RNA metabolism, and translation. Implications: These findings demonstrate the clinical relevancy of expressed HPV integration, which is characterized by a change in immune response and/or aberrant expression of the integration-harboring cancer-related genes, and suggest strong natural selection for tumor cells with expressed integration events in key carcinogenic genes. Mol Cancer Res; 16(1); 90-102. ©2017 AACR . ©2017 American Association for Cancer Research.

  4. A compliance testing program for diagnostic X-ray equipment

    International Nuclear Information System (INIS)

    Hutchinson, D.E.; Cobb, B.J.; Jacob, C.S.

    1999-01-01

    Compliance testing is nominally that part of a quality assurance program dealing with those aspects of X-ray equipment performance that are subject to radiation control legislation. Quality assurance programs for medical X-ray equipment should be an integral part of the quality culture in health care. However while major hospitals and individual medical centers may implement such programs with some diligence, much X-ray equipment can remain unappraised unless there is a comprehensive regulatory inspection program or some form of compulsion on the equipment owner to implement a testing program. Since the late 1950s all X-ray equipment in the State of Western Australia has been inspected by authorized officers acting on behalf of the Radiological Council, the regulatory authority responsible for administration of the State's Radiation Safety Act. However, economic constraints, coupled with increasing X-ray equipment numbers and a geographically large State have significantly affected the inspection rate. Data available from inspections demonstrate that regular compliance and performance checks are essential in order to ensure proper performance and to minimize unnecessary patient and operator dose. To ensure that diagnostic X-ray equipment complies with accepted standards and performance criteria, the regulatory authority introduced a compulsory compliance testing program for all medical, dental and chiropractic diagnostic X-ray equipment effective from 1 January 1997

  5. A comparison of integrated and fiber optic responses in the presence of nuclear fields

    International Nuclear Information System (INIS)

    Taylor, E.W.; Wilson, V.R.; Sanchez, A.D.; Coughenour, M.; Chapman, S.

    1988-01-01

    A short survey of past experimental results is presented along with new investigative data, mathematical and physical response models and a comparison of the nuclear effects compatibility of fiber and integrated optic guided wave structures. The disparity in radiation resistance between optical fibers and guided wave structures is discussed and predictions are offered on the impact that these differences may have on influencing the eventual development of totally integrated radiation resistant structures

  6. White matter integrity as a predictor of response to treatment in first episode psychosis.

    Science.gov (United States)

    Reis Marques, Tiago; Taylor, Heather; Chaddock, Chris; Dell'acqua, Flavio; Handley, Rowena; Reinders, A A T Simone; Mondelli, Valeria; Bonaccorso, Stefania; Diforti, Marta; Simmons, Andrew; David, Anthony S; Murray, Robin M; Pariante, Carmine M; Kapur, Shitij; Dazzan, Paola

    2014-01-01

    The integrity of brain white matter connections is central to a patient's ability to respond to pharmacological interventions. This study tested this hypothesis using a specific measure of white matter integrity, and examining its relationship to treatment response using a prospective design in patients within their first episode of psychosis. Diffusion tensor imaging data were acquired in 63 patients with first episode psychosis and 52 healthy control subjects (baseline). Response was assessed after 12 weeks and patients were classified as responders or non-responders according to treatment outcome. At this second time-point, they also underwent a second diffusion tensor imaging scan. Tract-based spatial statistics were used to assess fractional anisotropy as a marker of white matter integrity. At baseline, non-responders showed lower fractional anisotropy than both responders and healthy control subjects (P psychosis. These data, together with earlier findings on cortical grey matter, suggest that grey and white matter integrity at the start of treatment is an important moderator of response to antipsychotics. These findings can inform patient stratification to anticipate care needs, and raise the possibility that antipsychotics may restore white matter integrity as part of the therapeutic response.

  7. Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

    International Nuclear Information System (INIS)

    Calabrese, Edward J.; Bachmann, Kenneth A.; Bailer, A. John; Bolger, P. Michael; Borak, Jonathan; Cai, Lu; Cedergreen, Nina; Cherian, M. George; Chiueh, Chuang C.; Clarkson, Thomas W.; Cook, Ralph R.; Diamond, David M.; Doolittle, David J.; Dorato, Michael A.; Duke, Stephen O.; Feinendegen, Ludwig; Gardner, Donald E.; Hart, Ronald W.; Hastings, Kenneth L.; Hayes, A. Wallace; Hoffmann, George R.; Ives, John A.; Jaworowski, Zbigniew; Johnson, Thomas E.; Jonas, Wayne B.; Kaminski, Norbert E.; Keller, John G.; Klaunig, James E.; Knudsen, Thomas B.; Kozumbo, Walter J.; Lettieri, Teresa; Liu, Shu-Zheng; Maisseu, Andre; Maynard, Kenneth I.; Masoro, Edward J.; McClellan, Roger O.; Mehendale, Harihara M.; Mothersill, Carmel; Newlin, David B.; Nigg, Herbert N.; Oehme, Frederick W.; Phalen, Robert F.; Philbert, Martin A.; Rattan, Suresh I.S.; Riviere, Jim E.; Rodricks, Joseph; Sapolsky, Robert M.; Scott, Bobby R.; Seymour, Colin; Sinclair, David A.; Smith-Sonneborn, Joan; Snow, Elizabeth T.; Spear, Linda; Stevenson, Donald E.; Thomas, Yolene; Tubiana, Maurice; Williams, Gary M.; Mattson, Mark P.

    2007-01-01

    Many biological subdisciplines that regularly assess dose-response relationships have identified an evolutionarily conserved process in which a low dose of a stressful stimulus activates an adaptive response that increases the resistance of the cell or organism to a moderate to severe level of stress. Due to a lack of frequent interaction among scientists in these many areas, there has emerged a broad range of terms that describe such dose-response relationships. This situation has become problematic because the different terms describe a family of similar biological responses (e.g., adaptive response, preconditioning, hormesis), adversely affecting interdisciplinary communication, and possibly even obscuring generalizable features and central biological concepts. With support from scientists in a broad range of disciplines, this article offers a set of recommendations we believe can achieve greater conceptual harmony in dose-response terminology, as well as better understanding and communication across the broad spectrum of biological disciplines

  8. Integrating Corporate Social Responsability Programs into the Ethical Dimension of the Organization

    OpenAIRE

    Ibrian CARAMIDARU; Sabina IRIMIE

    2011-01-01

    The purpose of this paper is to indicate the need to integrate corporate social responsibility programs into the global ethical vision of organizations. Such an approach requires the definition of the corporation in relation to the moral values it assumes and the ways in which moral values occur within the organization. On this foundation, the authors examined the various implications that moral values have on the initiation and conduct of corporate social responsibility programs.

  9. The Socio-ecological Fit of Human Responses to Environmental Degradation: An Integrated Assessment Methodology.

    Science.gov (United States)

    Briassoulis, Helen

    2015-12-01

    The scientific and policy interest in the human responses to environmental degradation usually focuses on responses sensu stricto and 'best practices' that potentially abate degradation in affected areas. The transfer of individual, discrete instruments and 'best practices' to different contexts is challenging, however, because socio-ecological systems are complex and environmental degradation is contextual and contingent. To sensibly assess the effectiveness of formal and informal interventions to combat environmental degradation, the paper proposes an integrative, non-reductionist analytic, the 'response assemblage', for the study of 'responses-in-context,' i.e., products of human decisions to utilize environmental resources to satisfy human needs in socio-ecological systems. Response assemblages are defined as geographically and historically unique, provisional, open, territorial wholes, complex compositions emerging from processes of assembling biophysical and human components, including responses sensu stricto, from affected focal and other socio-ecological systems, to serve human goals, one of which may be combatting environmental degradation. The degree of match among the components, called the socio-ecological fit of the response assemblage, indicates how effectively their contextual and contingent interactions maintain the socio-ecological resilience, promote sustainable development, and secure the continuous provision of ecosystem services in a focal socio-ecological system. The paper presents a conceptual approach to the analysis of the socio-ecological fit of response assemblages and details an integrated assessment methodology synthesizing the resilience, assemblage, and 'problem of fit' literature. Lastly, it summarizes the novelty, value, and policy relevance of conceptualizing human responses as response assemblages and of the integrated assessment methodology, reconsiders 'best practices' and suggests selected future research directions.

  10. The Socio-ecological Fit of Human Responses to Environmental Degradation: An Integrated Assessment Methodology

    Science.gov (United States)

    Briassoulis, Helen

    2015-12-01

    The scientific and policy interest in the human responses to environmental degradation usually focuses on responses sensu stricto and `best practices' that potentially abate degradation in affected areas. The transfer of individual, discrete instruments and `best practices' to different contexts is challenging, however, because socio-ecological systems are complex and environmental degradation is contextual and contingent. To sensibly assess the effectiveness of formal and informal interventions to combat environmental degradation, the paper proposes an integrative, non-reductionist analytic, the `response assemblage', for the study of `responses-in-context,' i.e., products of human decisions to utilize environmental resources to satisfy human needs in socio-ecological systems. Response assemblages are defined as geographically and historically unique, provisional, open, territorial wholes, complex compositions emerging from processes of assembling biophysical and human components, including responses sensu stricto, from affected focal and other socio-ecological systems, to serve human goals, one of which may be combatting environmental degradation. The degree of match among the components, called the socio- ecological fit of the response assemblage, indicates how effectively their contextual and contingent interactions maintain the socio-ecological resilience, promote sustainable development, and secure the continuous provision of ecosystem services in a focal socio-ecological system. The paper presents a conceptual approach to the analysis of the socio-ecological fit of response assemblages and details an integrated assessment methodology synthesizing the resilience, assemblage, and `problem of fit' literature. Lastly, it summarizes the novelty, value, and policy relevance of conceptualizing human responses as response assemblages and of the integrated assessment methodology, reconsiders `best practices' and suggests selected future research directions.

  11. Medical Issues: Equipment

    Science.gov (United States)

    ... Information Packets Equipment Pool Living With SMA Medical Issues Palliative Breathing Orthopedics Nutrition Equipment Daily Life At ... curesma.org > support & care > living with sma > medical issues > equipment Equipment Individuals with SMA often require a ...

  12. Performance of integrated systems of automated roller shade systems and daylight responsive dimming systems

    Energy Technology Data Exchange (ETDEWEB)

    Park, Byoung-Chul; Choi, An-Seop; Jeong, Jae-Weon [Department of Architectural Engineering, Sejong University, Kunja-Dong, Kwangjin-Gu, Seoul (Korea, Republic of); Lee, Eleanor S. [Building Technologies Department, Lawrence Berkeley National Laboratory, Berkeley, CA (United States)

    2011-03-15

    Daylight responsive dimming systems have been used in few buildings to date because they require improvements to improve reliability. The key underlying factor contributing to poor performance is the variability of the ratio of the photosensor signal to daylight workplane illuminance in accordance with sun position, sky condition, and fenestration condition. Therefore, this paper describes the integrated systems between automated roller shade systems and daylight responsive dimming systems with an improved closed-loop proportional control algorithm, and the relative performance of the integrated systems and single systems. The concept of the improved closed-loop proportional control algorithm for the integrated systems is to predict the varying correlation of photosensor signal to daylight workplane illuminance according to roller shade height and sky conditions for improvement of the system accuracy. In this study, the performance of the integrated systems with two improved closed-loop proportional control algorithms was compared with that of the current (modified) closed-loop proportional control algorithm. In the results, the average maintenance percentage and the average discrepancies of the target illuminance, as well as the average time under 90% of target illuminance for the integrated systems significantly improved in comparison with the current closed-loop proportional control algorithm for daylight responsive dimming systems as a single system. (author)

  13. Mass Market Demand Response and Variable Generation Integration Issues: A Scoping Study

    Energy Technology Data Exchange (ETDEWEB)

    Cappers, Peter; Mills, Andrew; Goldman, Charles; Wiser, Ryan; Eto, Joseph H.

    2011-09-10

    This scoping study focuses on the policy issues inherent in the claims made by some Smart Grid proponents that the demand response potential of mass market customers which is enabled by widespread implementation of Advanced Metering Infrastructure (AMI) through the Smart Grid could be the “silver bullet” for mitigating variable generation integration issues. In terms of approach, we will: identify key issues associated with integrating large amounts of variable generation into the bulk power system; identify demand response opportunities made more readily available to mass market customers through widespread deployment of AMI systems and how they can affect the bulk power system; assess the extent to which these mass market Demand Response (DR) opportunities can mitigate Variable Generation (VG) integration issues in the near-term and what electricity market structures and regulatory practices could be changed to further expand the ability for DR to mitigate VG integration issues over the long term; and provide a qualitative comparison of DR and other approaches to mitigate VG integration issues.

  14. The Integration of Energy Efficiency, Renewable Energy, DemandResponse and Climate Change: Challenges and Opportunities for Evaluatorsand Planners

    Energy Technology Data Exchange (ETDEWEB)

    Vine, Edward

    2007-05-29

    This paper explores the feasibility of integrating energyefficiency program evaluation with the emerging need for the evaluationof programs from different "energy cultures" (demand response, renewableenergy, and climate change). The paper reviews key features andinformation needs of the energy cultures and critically reviews theopportunities and challenges associated with integrating these withenergy efficiency program evaluation. There is a need to integrate thedifferent policy arenas where energy efficiency, demand response, andclimate change programs are developed, and there are positive signs thatthis integration is starting to occur.

  15. Semiconductor Manufacturing equipment introduction

    International Nuclear Information System (INIS)

    Im, Jong Sun

    2001-02-01

    This book deals with semiconductor manufacturing equipment. It is comprised of nine chapters, which are manufacturing process of semiconductor device, history of semiconductor manufacturing equipment, kinds and role of semiconductor manufacturing equipment, construction and method of semiconductor manufacturing equipment, introduction of various semiconductor manufacturing equipment, spots of semiconductor manufacturing, technical elements of semiconductor manufacturing equipment, road map of technology of semiconductor manufacturing equipment and semiconductor manufacturing equipment in the 21st century.

  16. Attention, spatial integration, and the tail of response time distributions in Stroop task performance

    NARCIS (Netherlands)

    Roelofs, A.P.A.

    2012-01-01

    A few studies have examined selective attention in Stroop task performance through ex-Gaussian analyses of response time (RT) distributions. It has remained unclear whether the tail of the RT distribution in vocal responding reflects spatial integration of relevant and irrelevant attributes, as

  17. Pivoting from Arabidopsis to wheat to understand how agricultural plants integrate responses to biotic stress

    Science.gov (United States)

    Here we argue for a research initiative on gene-for-gene (g-f-g) interactions between wheat and its parasites. One aim is to begin a conversation between the disparate communities of plant pathology and entomology. Another is to understand how responses to biotic stress are integrated in an import...

  18. Integrating ecosystem services and climate change responses in coastal wetlands development plans for Bangladesh

    NARCIS (Netherlands)

    Sarwar, M.H.; Hein, L.G.; Rip, F.I.; Dearing, J.A.

    2015-01-01

    This study explores the integration of ecosystem services and climate change adaptation in development plans for coastal wetlands in Bangladesh. A new response framework for adaptation is proposed, based on an empirical analysis and consultations with stakeholders, using a modified version of the

  19. Spatial integration of local transmitter responses in motoneurones of the turtle spinal cord in vitro

    DEFF Research Database (Denmark)

    Skydsgaard, Morten Arnika; Hounsgaard, J

    1994-01-01

    1. Integration of responses to local activation of transmitter receptors in the dendrites of motoneurones was investigated in a slice preparation of the turtle spinal cord. Membrane-active substances were applied from up to three independent iontophoresis electrodes during intracellular recording...

  20. Integrating Social Responsibility into an Entrepreneurship Education Program: A Case Study

    Science.gov (United States)

    Maistry, Suriamurthee Moonsamy; Ramdhani, Jugathambal

    2010-01-01

    Entrepreneurship education in South Africa is often presented as a neutral discipline. Yet fundamental to any entrepreneurship education program should be the integration of key issues, such as ethics, values and social responsibility. This paper reports on a study that set out to explore student teachers experiences of engaging in an…

  1. The Integrity of the Tax System after BEPS: A Shared Responsibility

    NARCIS (Netherlands)

    H. Gribnau (Hans)

    2017-01-01

    textabstractThe international tax system is the result of the interaction of different actors who share the responsibility for its integrity. States and multinational corporations both enjoy to a certain extent freedom of choice with regard to their tax behaviour – which entails moral

  2. The passive response of the Integral Fast Reactor concept to the chilled inlet accident

    International Nuclear Information System (INIS)

    Vilim, R.B.

    1990-01-01

    Simple methods are described for bounding the passive response of a metal fueled liquid-metal cooled reactor to the chilled inlet accident. Calculation of these bounds for a prototype of the Integral Fast Reactor concept shows that failure limits --- eutectic melting, sodium boiling and fuel pin failure --- are not exceeded. 2 refs., 1 fig., 2 tabs

  3. Integrating Response to Intervention (RTI) with Neuropsychology: A Scientific Approach to Reading

    Science.gov (United States)

    Feifer, Steven G.

    2008-01-01

    This article integrates the fundamental components of both "Response to Intervention" (RTI) and cognitive neuropsychology when identifying reading disorders in children. Both proponents of RTI and cognitive neuropsychology agree the "discrepancy model" is not a reliable or valid method to identify learning disorders in school. In addition, both…

  4. Methodology of assessment of the impact on the risk of changes in peak times of unavailability of safety equipment integrating treatment and analysis of uncertainties

    International Nuclear Information System (INIS)

    Martorell, S.; Villamizar, M.; Marton, I.; Villanueva, J. f.; Carlos, S.; Sanchez, A. I.

    2013-01-01

    Surveillance of safety equipment requirements form parts of the technical specifications of Performance included in the bases of operation of nuclear power plants license, so they are center of attention in the study of improvements to the safety of the operation of the plant using different methods, both traditional deterministic as probabilistic.

  5. Life sciences payload definition and integration study. Volume 3: Preliminary equipment item specification catalog for the carry-on laboratories. [for Spacelab

    Science.gov (United States)

    1974-01-01

    All general purpose equipment items contained in the final carry-on laboratory (COL) design concepts are described in terms of specific requirements identified for COL use, hardware status, and technical parameters such as weight, volume, power, range, and precision. Estimated costs for each item are given, along with projected development times.

  6. The social-financial responsible reporting – the key for integrated reporting

    Directory of Open Access Journals (Sweden)

    Iulia Jianu

    2012-08-01

    Full Text Available General purpose of financial statements is to satisfy the needs of users who are not in the position to require of the entity to prepare reports tailored to their particular information needs. Because the public is one of these users interested of social information and because the financial statement do not provide sufficient social information to satisfy these needs, the study demonstrate the need to integrate the responsible social reporting into financial reporting. In order to support this reason, taking into account the data supplied by the entities listed on the Global Reporting Initiative regarding the corporate social responsibility. The results of the study show that social indicators can be disclosed in a monetary form which reinforces the need for their integration into financial reporting and the need to define a new concept: the social – financial responsible reporting.

  7. Metabolome Integrated Analysis of High-Temperature Response in Pinus radiata

    Directory of Open Access Journals (Sweden)

    Mónica Escandón

    2018-04-01

    Full Text Available The integrative omics approach is crucial to identify the molecular mechanisms underlying high-temperature response in non-model species. Based on future scenarios of heat increase, Pinus radiata plants were exposed to a temperature of 40°C for a period of 5 days, including recovered plants (30 days after last exposure to 40°C in the analysis. The analysis of the metabolome using complementary mass spectrometry techniques (GC-MS and LC-Orbitrap-MS allowed the reliable quantification of 2,287 metabolites. The analysis of identified metabolites and highlighter metabolic pathways across heat time exposure reveal the dynamism of the metabolome in relation to high-temperature response in P. radiata, identifying the existence of a turning point (on day 3 at which P. radiata plants changed from an initial stress response program (shorter-term response to an acclimation one (longer-term response. Furthermore, the integration of metabolome and physiological measurements, which cover from the photosynthetic state to hormonal profile, suggests a complex metabolic pathway interaction network related to heat-stress response. Cytokinins (CKs, fatty acid metabolism and flavonoid and terpenoid biosynthesis were revealed as the most important pathways involved in heat-stress response in P. radiata, with zeatin riboside (ZR and isopentenyl adenosine (iPA as the key hormones coordinating these multiple and complex interactions. On the other hand, the integrative approach allowed elucidation of crucial metabolic mechanisms involved in heat response in P. radiata, as well as the identification of thermotolerance metabolic biomarkers (L-phenylalanine, hexadecanoic acid, and dihydromyricetin, crucial metabolites which can reschedule the metabolic strategy to adapt to high temperature.

  8. The iso-response method: measuring neuronal stimulus integration with closed-loop experiments

    Science.gov (United States)

    Gollisch, Tim; Herz, Andreas V. M.

    2012-01-01

    Throughout the nervous system, neurons integrate high-dimensional input streams and transform them into an output of their own. This integration of incoming signals involves filtering processes and complex non-linear operations. The shapes of these filters and non-linearities determine the computational features of single neurons and their functional roles within larger networks. A detailed characterization of signal integration is thus a central ingredient to understanding information processing in neural circuits. Conventional methods for measuring single-neuron response properties, such as reverse correlation, however, are often limited by the implicit assumption that stimulus integration occurs in a linear fashion. Here, we review a conceptual and experimental alternative that is based on exploring the space of those sensory stimuli that result in the same neural output. As demonstrated by recent results in the auditory and visual system, such iso-response stimuli can be used to identify the non-linearities relevant for stimulus integration, disentangle consecutive neural processing steps, and determine their characteristics with unprecedented precision. Automated closed-loop experiments are crucial for this advance, allowing rapid search strategies for identifying iso-response stimuli during experiments. Prime targets for the method are feed-forward neural signaling chains in sensory systems, but the method has also been successfully applied to feedback systems. Depending on the specific question, “iso-response” may refer to a predefined firing rate, single-spike probability, first-spike latency, or other output measures. Examples from different studies show that substantial progress in understanding neural dynamics and coding can be achieved once rapid online data analysis and stimulus generation, adaptive sampling, and computational modeling are tightly integrated into experiments. PMID:23267315

  9. Chicken hepatic response to chronic heat stress using integrated transcriptome and metabolome analysis.

    Directory of Open Access Journals (Sweden)

    Sara F Jastrebski

    Full Text Available The liver plays a central role in metabolism and is important in maintaining homeostasis throughout the body. This study integrated transcriptomic and metabolomic data to understand how the liver responds under chronic heat stress. Chickens from a rapidly growing broiler line were heat stressed for 8 hours per day for one week and liver samples were collected at 28 days post hatch. Transcriptome analysis reveals changes in genes responsible for cell cycle regulation, DNA replication, and DNA repair along with immune function. Integrating the metabolome and transcriptome data highlighted multiple pathways affected by heat stress including glucose, amino acid, and lipid metabolism along with glutathione production and beta-oxidation.

  10. Analytic Lorentz integral transform of an arbitrary response function and its application to the inversion problem

    International Nuclear Information System (INIS)

    Barnea, N.; Liverts, E.

    2010-01-01

    In this paper we present an analytic expression for the Lorentz integral transform of an arbitrary response function expressed as a polynomial times a decaying exponent. The resulting expression is applied to the inversion problem of the Lorentz integral transform, simplifying the inversion procedure and improving the accuracy of the procedure. We have presented analytic formulae for a family of basis function often used in the inversion of the LIT function. These formulae allow for an efficient and accurate inversion. The quality and the stability of the resulting inversions were demonstrated through two different examples yielding outstanding results. (author)

  11. Integration scenarios of Demand Response into electricity markets: Load shifting, financial savings and policy implications

    International Nuclear Information System (INIS)

    Feuerriegel, Stefan; Neumann, Dirk

    2016-01-01

    Demand Response allows for the management of demand side resources in real-time; i.e. shifting electricity demand according to fluctuating supply. When integrated into electricity markets, Demand Response can be used for load shifting and as a replacement for both control reserve and balancing energy. These three usage scenarios are compared based on historic German data from 2011 to determine that load shifting provides the highest benefit: its annual financial savings accumulate to €3.110 M for both households and the service sector. This equals to relative savings of 2.83% compared to a scenario without load shifting. To improve Demand Response integration, the proposed model suggests policy implications: reducing bid sizes, delivery periods and the time-lag between market transactions and delivery dates in electricity markets. - Highlights: •Comparison of 3 scenarios to integrate Demand Response into electricity markets. •These are: optimize procurement, offer as control reserve, avoid balancing energy. •Ex post simulation to quantify financial impact and policy implications. •Highest savings from load shifting with a cost reduction of 3%. •Model suggests reducing bid sizes, delivery periods and time lags as policy issues.

  12. Should we learn culture in chemistry classroom? Integration ethnochemistry in culturally responsive teaching

    Science.gov (United States)

    Rahmawati, Yuli; Ridwan, Achmad; Nurbaity

    2017-08-01

    The papers report the first year of two-year longitudinal study of ethnochemistry integration in culturally responsive teaching in chemistry classrooms. The teaching approach is focusing on exploring the culture and indigenous knowledge in Indonesia from chemistry perspectives. Ethnochemistry looks at the culture from chemistry perspectives integrated into culturally responsive teaching has developed students' cultural identity and students' engagement in chemistry learning. There are limited research and data in exploring Indonesia culture, which has around 300 ethics, from chemistry perspectives. Students come to the chemistry classrooms from a different background; however, their chemistry learning disconnected with their background which leads to students' disengagement in chemistry learning. Therefore this approach focused on students' engagement within their differences. This research was conducted with year 10 and 11 from four classrooms in two secondary schools through qualitative methodology with observation, interviews, and reflective journals as data collection. The results showed that the integration of ethnochemistry in culturally responsive teaching approach can be implemented by involving 5 principles which are content integration, facilitating knowledge construction, prejudice reduction, social justice, and academic development. The culturally responsive teaching has engaged students in their chemistry learning and developed their cultural identity and soft skills. Students found that the learning experiences has helped to develop their chemistry knowledge and understand the culture from chemistry perspectives. The students developed the ability to work together, responsibility, curiosity, social awareness, creativity, empathy communication, and self-confidence which categorized into collaboration skills, student engagement, social and cultural awareness, and high order thinking skills. The ethnochemistry has helped them to develop the critical self

  13. Conceptual analysis of social responsibility of the person and its integration in pharmaceutical practice

    Directory of Open Access Journals (Sweden)

    N. O. Tkachenko

    2017-12-01

    Full Text Available The modern development of the social policy of pharmaceutical organizations in Ukraine, focused on the needs of society, is characterized by the lag in practical implementation of appropriate social responsibility (SR from the increased interest of pharmaceutical scientists in its various aspects. Issues of personal identity, its role and place in the system of socially responsible behavior of pharmaceutical organizations and the professional activity of pharmacists remain insufficiently studied. The purpose research. Conceptual analysis of the social responsibility of the individual with the integration into pharmacy and the rationale for strategic directions for the formation of social responsibility as a professional competence of pharmacists in the system of continuous pharmaceutical education. Materials and methods. We used the methods of information retrieval, comparison, systematization, analysis, synthesis and modeling. Materials for research were publications of fundamental and applied research of domestic and foreign scientists on issues of social responsibility, international standards. Results. Personality in the process of activity is both the subject and the object of responsibility, since social responsibility is a condition for interaction between the individual and the society. The social responsibility of pharmacy specialists directed to primary and secondary social groups, society and the individual, as well as to oneself. In the latter case, the self-concept is important, that is, the individual's complete self-image and the readiness of the individual to act in a certain way in certain situations, as well as the possible social roles of the pharmacist. The process of forming the social responsibility of pharmacy specialists is a complex level system that continuously educates, develops and improves the skill of social responsibility throughout professional life. Conclusions. On the basis of theoretical generalization of the

  14. Selection of equipment for equipment qualification

    International Nuclear Information System (INIS)

    Torr, K.G.

    1989-01-01

    This report describes the methodology applied in selecting equipment in the special safety systems for equipment qualification in the CANDU 600 MW nuclear generating stations at Gentilly 2 and Point Lepreau. Included is an explanation of the selection procedure adopted and the rationale behind the criteria used in identifying the equipment. The equipment items on the list have been grouped into three priority categories as a planning aid to AECB staff for a review of the qualification status of the special safety systems

  15. A calibration method for the measurement of IR detector spectral responses using a FTIR spectrometer equipped with a DTGS reference cell

    Science.gov (United States)

    Gravrand, Olivier; Wlassow, J.; Bonnefond, L.

    2014-07-01

    Various high performance IR detectors are today available on the market from QWIPs to narrow gap semiconductor photodiodes, which exhibit various spectral features. In the astrophysics community, the knowledge of the detector spectral shape is of first importance. This quantity (spectral QE or response) is usually measured by means of a monochromator followed by an integrating sphere and compared to a calibrated reference detector. This approach is usually very efficient in the visible range, where all optical elements are very well known, particularly the reference detector. This setup is also widely used in the near IR (up to 3μm) but as the wavelength increases, it becomes less efficient. For instance, the internal emittance of integrating spheres in the IR, and the bad knowledge of reference detectors for longer wavelengths tend to degrade the measurement reliability. Another approach may therefore be considered, using a Fourier transform IR spectrometer (FTIR). In this case, as opposed to the monochromator, the tested detector is not in low flux condition, the incident light containing a mix of different wavelengths. Therefore, the reference detector has to be to be sensitive (and known) in the whole spectral band of interest, because it will sense all those wavelengths at the same time. A popular detector used in this case is a Deuterated Triglycine Sulfate thermal detector (DTGS). Being a pyro detetector, the spectral response of such a detector is very flat, mainly limited by its window. However, the response of such a detector is very slow, highly depending on the temporal frequency of the input signal. Moreover, being a differential detector, it doesn't work in DC. In commercial FTIR spectrometers, the source luminance is usually continuously modulated by the moving interferometer, and the result is that the interferogram mixes optical spectral information (optical path difference) and temporal variations (temporal frequency) so that the temporal

  16. Developing equipment for AGR remote visual inspection

    International Nuclear Information System (INIS)

    James, P.W.; Walton, P.J.

    1985-01-01

    The Remote Inspection Group is part of the CEGB's Generation Development and Construction Division, and has responsibility for the design, development, procurement, testing and setting to work of the equipment provided to carry out routine remote visual inspections of its AGRs. This equipment includes both the viewing devices and the necessary placement equipment. (author)

  17. Ethical Responsibility of Governance for Integrating Disaster Risk Reduction with Development

    Science.gov (United States)

    Parkash Gupta, Surya

    2015-04-01

    The development in the public as well as the private sectors is controlled and regulated, directly or indirectly by the governments at federal, provincial and local levels. If this development goes haphazard and unplanned, without due considerations to environmental constraints and potential hazards; it is likely to cause disasters or may get affected by disasters. Therefore, it becomes an ethical responsibility of the people involved in governance sector to integrate disaster risk reduction with development in their administrative territories through enforcement of appropriate policies, guidelines and regulatory mechanisms. Such mechanisms should address the social, scientific, economic, environmental, and legal requirements that play significant role in planning, implementation of developmental activities as well as disaster management. The paper focuses on defining the ethical responsibilities for the governance sector for integrating disaster risk reduction with development. It highlights the ethical issues with examples from two case studies, one from the Uttarakhand state and the other Odhisa state in India. The case studies illustrates how does it make a difference in disaster risk reduction if the governments own or do not own ethical responsibilities. The paper considers two major disaster events, flash floods in Uttarakhand state and Cyclone Phailin in Odhisa state, that happened during the year 2013. The study points out that it makes a great difference in terms of consequences and response to disasters when ethical responsibilities are owned by the governance sector. The papers attempts to define these ethical responsibilities for integrating disaster risk reduction with development so that the governments can be held accountable for their acts or non-actions.

  18. Development of an integrated response generator for Si/CdTe semiconductor Compton cameras

    International Nuclear Information System (INIS)

    Odaka, Hirokazu; Sugimoto, Soichiro; Ishikawa, Shin-nosuke; Katsuta, Junichiro; Koseki, Yuu; Fukuyama, Taro; Saito, Shinya; Sato, Rie; Sato, Goro; Watanabe, Shin

    2010-01-01

    We have developed an integrated response generator based on Monte Carlo simulation for Compton cameras composed of silicon (Si) and cadmium telluride (CdTe) semiconductor detectors. In order to construct an accurate detector response function, the simulation is required to include a comprehensive treatment of the semiconductor detector devices and the data processing system in addition to simulating particle tracking. Although CdTe is an excellent semiconductor material for detection of soft gamma rays, its ineffective charge transport property distorts its spectral response. We investigated the response of CdTe pad detectors in the simulation and present our initial results here. We also performed the full simulation of prototypes of Si/CdTe semiconductor Compton cameras and report on the reproducibility of detection efficiencies and angular resolutions of the cameras, both of which are essential performance parameters of astrophysical instruments.

  19. A double-integration hypothesis to explain ocean ecosystem response to climate forcing

    Science.gov (United States)

    Di Lorenzo, Emanuele; Ohman, Mark D.

    2013-01-01

    Long-term time series of marine ecological indicators often are characterized by large-amplitude state transitions that can persist for decades. Understanding the significance of these variations depends critically on the underlying hypotheses characterizing expected natural variability. Using a linear autoregressive model in combination with long-term zooplankton observations off the California coast, we show that cumulative integrations of white-noise atmospheric forcing can generate marine population responses that are characterized by strong transitions and prolonged apparent state changes. This model provides a baseline hypothesis for explaining ecosystem variability and for interpreting the significance of abrupt responses and climate change signatures in marine ecosystems. PMID:23341628

  20. An electrically actuated imperfect microbeam: Dynamical integrity for interpreting and predicting the device response

    KAUST Repository

    Ruzziconi, Laura

    2013-02-20

    In this study we deal with a microelectromechanical system (MEMS) and develop a dynamical integrity analysis to interpret and predict the experimental response. The device consists of a clamped-clamped polysilicon microbeam, which is electrostatically and electrodynamically actuated. It has non-negligible imperfections, which are a typical consequence of the microfabrication process. A single-mode reduced-order model is derived and extensive numerical simulations are performed in a neighborhood of the first symmetric natural frequency, via frequency response diagrams and behavior chart. The typical softening behavior is observed and the overall scenario is explored, when both the frequency and the electrodynamic voltage are varied. We show that simulations based on direct numerical integration of the equation of motion in time yield satisfactory agreement with the experimental data. Nevertheless, these theoretical predictions are not completely fulfilled in some aspects. In particular, the range of existence of each attractor is smaller in practice than in the simulations. This is because these theoretical curves represent the ideal limit case where disturbances are absent, which never occurs under realistic conditions. A reliable prediction of the actual (and not only theoretical) range of existence of each attractor is essential in applications. To overcome this discrepancy and extend the results to the practical case where disturbances exist, a dynamical integrity analysis is developed. After introducing dynamical integrity concepts, integrity profiles and integrity charts are drawn. They are able to describe if each attractor is robust enough to tolerate the disturbances. Moreover, they detect the parameter range where each branch can be reliably observed in practice and where, instead, becomes vulnerable, i.e. they provide valuable information to operate the device in safe conditions according to the desired outcome and depending on the expected disturbances

  1. Secure, Autonomous, Intelligent Controller for Integrating Distributed Emergency Response Satellite Operations

    Science.gov (United States)

    Ivancic, William D.; Paulsen, Phillip E.; Miller, Eric M.; Sage, Steen P.

    2013-01-01

    This report describes a Secure, Autonomous, and Intelligent Controller for Integrating Distributed Emergency Response Satellite Operations. It includes a description of current improvements to existing Virtual Mission Operations Center technology being used by US Department of Defense and originally developed under NASA funding. The report also highlights a technology demonstration performed in partnership with the United States Geological Service for Earth Resources Observation and Science using DigitalGlobe(Registered TradeMark) satellites to obtain space-based sensor data.

  2. Green Marketing: integrated social and environmental responsibility in the marketing environment

    OpenAIRE

    Dalmoro, Marlon; Venturini, Jonas Cardona; Diniz Pereira, Breno Augusto

    2009-01-01

    This study aims to describe and analyze as social and environmental responsibility is integrated in the marketing strategy of a Coca-Cola Company franchisee. By the perceptions of Karna, Hansen and Juslin (2001), environment marketing is described based on three hierarchical levels: strategic, structural and functional marketing. There has been developed a qualitative approach through case study, in which the data were collected through semi-structured interviews with people involved in the p...

  3. “Toward socially responsible agents: integrating attachment and learning in emotional decision-making,”

    OpenAIRE

    M. Ben Moussa and N. Magnenat-Thalmann

    2013-01-01

    Our goal is to create socially responsible agents either robots or virtual humans. In this paper we present an integration of emotions attachment and learning in emotional decision making to achieve this goal. Based on emerging psychological theories we aim at building human like emotional decision making where emotions play a central role in selecting the next action to be performed by the agent. Here we present our own approach for emotion appraisal where we use emotional attachment as an i...

  4. The Social-Financial Responsible Reporting – The Key for Integrated Reporting

    OpenAIRE

    Iulia Jianu

    2012-01-01

    General purpose of financial statements is to satisfy the needs of users who are not in the position to require of the entity to prepare reports tailored to their particular information needs. Because the public is one of these users interested of social information and because the financial statement do not provide sufficient social information to satisfy these needs, the study demonstrate the need to integrate the responsible social reporting into financial reporting. In order to support th...

  5. Dynamic response characteristics of dual flow-path integrally bladed rotors

    Science.gov (United States)

    Beck, Joseph A.; Brown, Jeffrey M.; Scott-Emuakpor, Onome E.; Cross, Charles J.; Slater, Joseph C.

    2015-02-01

    New turbine engine designs requiring secondary flow compression often look to dual flow-path integrally bladed rotors (DFIBRs) since these stages have the ability to perform work on the secondary, or bypassed, flow-field. While analogous to traditional integrally bladed rotor stages, DFIBR designs have many differences that result in unique dynamic response characteristics that must be understood to avoid fatigue. This work investigates these characteristics using reduced-order models (ROMs) that incorporate mistuning through perturbations to blade frequencies. This work provides an alternative to computationally intensive geometric-mistuning approaches for DFIBRs by utilizing tuned blade mode reductions and substructure coupling in cyclic coordinates. Free and forced response results are compared to full finite element model (FEM) solutions to determine if any errors are related to the reduced-order model formulation reduction methods. It is shown that DFIBRs have many more frequency veering regions than their single flow-path integrally blade rotor (IBR) counterparts. Modal families are shown to transition between system, inner-blade, and outer-blade motion. Furthermore, findings illustrate that while mode localization of traditional IBRs is limited to a single or small subset of blades, DFIBRs can have modal energy localized to either an inner- or outer-blade set resulting in many blades responding above tuned levels. Lastly, ROM forced response predictions compare well to full FEM predictions for the two test cases shown.

  6. Modeling Framework and Validation of a Smart Grid and Demand Response System for Wind Power Integration

    Energy Technology Data Exchange (ETDEWEB)

    Broeer, Torsten; Fuller, Jason C.; Tuffner, Francis K.; Chassin, David P.; Djilali, Ned

    2014-01-31

    Electricity generation from wind power and other renewable energy sources is increasing, and their variability introduces new challenges to the power system. The emergence of smart grid technologies in recent years has seen a paradigm shift in redefining the electrical system of the future, in which controlled response of the demand side is used to balance fluctuations and intermittencies from the generation side. This paper presents a modeling framework for an integrated electricity system where loads become an additional resource. The agent-based model represents a smart grid power system integrating generators, transmission, distribution, loads and market. The model incorporates generator and load controllers, allowing suppliers and demanders to bid into a Real-Time Pricing (RTP) electricity market. The modeling framework is applied to represent a physical demonstration project conducted on the Olympic Peninsula, Washington, USA, and validation simulations are performed using actual dynamic data. Wind power is then introduced into the power generation mix illustrating the potential of demand response to mitigate the impact of wind power variability, primarily through thermostatically controlled loads. The results also indicate that effective implementation of Demand Response (DR) to assist integration of variable renewable energy resources requires a diversity of loads to ensure functionality of the overall system.

  7. Personal protective equipment

    International Nuclear Information System (INIS)

    2004-01-01

    This Practical Radiation Technical Manual is one of a series that has been designed to provide guidance on radiological protection for employers, radiation protection officers, managers and other technically competent persons who have responsibility for ensuring the safety of employees working with ionizing radiation. The Manual may be used with the appropriate IAEA Practical Radiation Safety Manuals to provide training, instruction and information for all employees engaged in work with ionizing radiation. Personal protective equipment (PPE) includes clothing or other special equipment that is issued to individual workers to provide protection against actual or potential exposure to ionizing radiations. It is used to protect each worker against the prevailing risk of external or internal exposure in circumstances in which it is not reasonably practicable to provide complete protection by means of engineering controls or administrative methods. Adequate personal protection depends on PPE being correctly selected, fitted and maintained. Appropriate training for the users and arrangements to monitor usage are also necessary to ensure that PPE provides the intended degree of protection effectively. This Manual explains the principal types of PPE, including protective clothing and respiratory protective equipment (RPE). Examples of working procedures are also described to indicate how PPE should be used within a safe system of work. The Manual will be of most benefit if it forms part of a more comprehensive training programme or is supplemented by the advice of a qualified expert in radiation protection. Some of the RPE described in this Manual should be used under the guidance of a qualified expert

  8. Owners responsibility of refrigeration equipment according F-Gas-regulation 'EC 842/2006' and answers; Betreiberpflichten nach 'F-Gas-Verordnung' EG 842/2006 und Antworten darauf

    Energy Technology Data Exchange (ETDEWEB)

    Beermann, Karsten [IKKE gGmbH, Duisburg (Germany)

    2012-08-15

    The results of the F-Gas-regulation EC 842/2006 are some responsibilities for owners of refrigeration equipment. To fulfill these duties exist e-learning training modules and different tools which are the result of a European LEONARDO- project. Particularly the awareness of the equipment owner and the certified person (refrigeration technician) according the regulation will be the main background of a safe handling of refrigerants for an effective environmental protection. Interested persons and companies will find helpful information to learn good practice. (orig.)

  9. Integrating Climate and Ecosystem-Response Sciences in Temperate Western North American Mountains: The CIRMOUNT Initiative

    Science.gov (United States)

    Millar, C. I.; Fagre, D. B.

    2004-12-01

    Mountain regions are uniquely sensitive to changes in climate, vulnerable to climate effects on biotic and physical factors of intense social concern, and serve as critical early-warning systems of climate impacts. Escalating demands on western North American (WNA) mountain ecosystems increasingly stress both natural resources and rural community capacities; changes in mountain systems cascade to issues of national concern. Although WNA has long been a focus for climate- and climate-related environmental research, these efforts remain disciplinary and poorly integrated, hindering interpretation into policy and management. Knowledge is further hampered by lack of standardized climate monitoring stations at high-elevations in WNA. An initiative is emerging as the Consortium for Integrated Climate Research in Western Mountains (CIRMOUNT) whose primary goal is to improve knowledge of high-elevation climate systems and to better integrate physical, ecological, and social sciences relevant to climate change, ecosystem response, and natural-resource policy in WNA. CIRMOUNT seeks to focus research on climate variability and ecosystem response (progress in understanding synoptic scale processes) that improves interpretation of linkages between ecosystem functions and human processing (progress in understanding human-environment integration), which in turn would yield applicable information and understanding on key societal issues such as mountains as water towers, biodiversity, carbon forest sinks, and wildland hazards such as fire and forest dieback (progress in understanding ecosystem services and key thresholds). Achieving such integration depends first on implementing a network of high-elevation climate-monitoring stations, and linking these with integrated ecosystem-response studies. Achievements since 2003 include convening the 2004 Mountain Climate Sciences Symposium (1, 2) and several special sessions at technical conferences; initiating a biennial mountain climate

  10. Using Gaming Equipment to Teach

    Science.gov (United States)

    Curriculum Review, 2009

    2009-01-01

    Gaming equipment (such as Nintendo's Wii[TM]) is making its way to schools and classrooms. However, most of the discussion regarding how to use this technology and integrate it into lesson plans is happening in blogs on the Internet. An advocate of interactive media in the classroom, Dr. Dawn Hawkins, a faculty member for the Art Institute of…

  11. The treatment of climate science in Integrated Assessment Modelling: integration of climate step function response in an energy system integrated assessment model.

    Science.gov (United States)

    Dessens, Olivier

    2016-04-01

    Integrated Assessment Models (IAMs) are used as crucial inputs to policy-making on climate change. These models simulate aspect of the economy and climate system to deliver future projections and to explore the impact of mitigation and adaptation policies. The IAMs' climate representation is extremely important as it can have great influence on future political action. The step-function-response is a simple climate model recently developed by the UK Met Office and is an alternate method of estimating the climate response to an emission trajectory directly from global climate model step simulations. Good et al., (2013) have formulated a method of reconstructing general circulation models (GCMs) climate response to emission trajectories through an idealized experiment. This method is called the "step-response approach" after and is based on an idealized abrupt CO2 step experiment results. TIAM-UCL is a technology-rich model that belongs to the family of, partial-equilibrium, bottom-up models, developed at University College London to represent a wide spectrum of energy systems in 16 regions of the globe (Anandarajah et al. 2011). The model uses optimisation functions to obtain cost-efficient solutions, in meeting an exogenously defined set of energy-service demands, given certain technological and environmental constraints. Furthermore, it employs linear programming techniques making the step function representation of the climate change response adapted to the model mathematical formulation. For the first time, we have introduced the "step-response approach" method developed at the UK Met Office in an IAM, the TIAM-UCL energy system, and we investigate the main consequences of this modification on the results of the model in term of climate and energy system responses. The main advantage of this approach (apart from the low computational cost it entails) is that its results are directly traceable to the GCM involved and closely connected to well-known methods of

  12. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  13. Nonassociative learning as gated neural integrator and differentiator in stimulus-response pathways

    Directory of Open Access Journals (Sweden)

    Young Daniel L

    2006-08-01

    Full Text Available Abstract Nonassociative learning is a basic neuroadaptive behavior exhibited across animal phyla and sensory modalities but its role in brain intelligence is unclear. Current literature on habituation and sensitization, the classic "dual process" of nonassociative learning, gives highly incongruous accounts between varying experimental paradigms. Here we propose a general theory of nonassociative learning featuring four base modes: habituation/primary sensitization in primary stimulus-response pathways, and desensitization/secondary sensitization in secondary stimulus-response pathways. Primary and secondary modes of nonassociative learning are distinguished by corresponding activity-dependent recall, or nonassociative gating, of neurotransmission memory. From the perspective of brain computation, nonassociative learning is a form of integral-differential calculus whereas nonassociative gating is a form of Boolean logic operator – both dynamically transforming the stimulus-response relationship. From the perspective of sensory integration, nonassociative gating provides temporal filtering whereas nonassociative learning affords low-pass, high-pass or band-pass/band-stop frequency filtering – effectively creating an intelligent sensory firewall that screens all stimuli for attention and resultant internal model adaptation and reaction. This unified framework ties together many salient characteristics of nonassociative learning and nonassociative gating and suggests a common kernel that correlates with a wide variety of sensorimotor integration behaviors such as central resetting and self-organization of sensory inputs, fail-safe sensorimotor compensation, integral-differential and gated modulation of sensorimotor feedbacks, alarm reaction, novelty detection and selective attention, as well as a variety of mental and neurological disorders such as sensorimotor instability, attention deficit hyperactivity, sensory defensiveness, autism

  14. Training requirements and responsibilities for the Buried Waste Integrated Demonstration at the Radioactive Waste Management Complex

    International Nuclear Information System (INIS)

    Vega, H.G.; French, S.B.; Rick, D.L.

    1992-09-01

    The Buried Waste Integrated Demonstration (BWID) is scheduled to conduct intrusive (hydropunch screening tests, bore hole installation, soil sampling, etc.) and nonintrusive (geophysical surveys) studies at the Radioactive Waste Management Complex (RWMC). These studies and activities will be limited to specific locations at the RWMC. The duration of these activities will vary, but most tasks are not expected to exceed 90 days. The BWID personnel requested that the Waste Management Operational Support Group establish the training requirements and training responsibilities for BWID personnel and BWID subcontractor personnel. This document specifies these training requirements and responsibilities. While the responsibilities of BWID and the RWMC are, in general, defined in the interface agreement, the training elements are based on regulatory requirements, DOE orders, DOE-ID guidance, state law, and the nature of the work to be performed

  15. Assessing the integration of health center and community emergency preparedness and response planning.

    Science.gov (United States)

    Wineman, Nicole V; Braun, Barbara I; Barbera, Joseph A; Loeb, Jerod M

    2007-11-01

    To assess the state of health center integration into community preparedness, we undertook a national study of linkages between health centers and the emergency preparedness and response planning initiatives in their communities. The key objectives of this project were to gain a better understanding of existing linkages in a nationally representative sample of health centers, and identify health center demographic and experience factors that were associated with strong linkages. The objectives of the study were to gain a baseline understanding of existing health center linkages to community emergency preparedness and response systems and to identify factors that were associated with strong linkages. A 60-item questionnaire was mailed to the population of health centers supported by the Health Resources and Services Administration's Bureau of Primary Health Care in February 2005. Results were aggregated and a chi square analysis identified factors associated with stronger linkages. Overall performance on study-defined indicators of strong linkages was low: 34% had completed a hazard vulnerability analysis in collaboration with the community emergency management agency, 30% had their role documented in the community plan, and 24% participated in community-wide exercises. Stronger linkages were associated with experience responding to a disaster and a perception of high risk for experiencing a disaster. The potential for health centers to participate in an integrated response is not fully realized, and their absence from community-based planning leaves an already vulnerable population at greater risk. Community planners should be encouraged to include health centers in planning and response and centers should receive more targeted resources for community integration.

  16. The use of a new PMOS monolithic integrated circuit for the electronic equipment of a large multiwire proportional chamber (MWPC) detection system

    International Nuclear Information System (INIS)

    Bareyre, P.; Borgeaud, P.; Poinsignon, J.; Billion, B.

    1975-01-01

    A new monolithic 8-channel PMOS integrated circuit has been developed for an experiment to be carried out on the CERN 300 GeV accelerator. The circuit, read-out electronics and tests performed on 12 large MWPCs (total of 48 000 channels) are described and the results are presented. (Auth.)

  17. Coral-zooxanthellae meta-transcriptomics reveals integrated response to pollutant stress.

    Science.gov (United States)

    Gust, Kurt A; Najar, Fares Z; Habib, Tanwir; Lotufo, Guilherme R; Piggot, Alan M; Fouke, Bruce W; Laird, Jennifer G; Wilbanks, Mitchell S; Rawat, Arun; Indest, Karl J; Roe, Bruce A; Perkins, Edward J

    2014-07-12

    Corals represent symbiotic meta-organisms that require harmonization among the coral animal, photosynthetic zooxanthellae and associated microbes to survive environmental stresses. We investigated integrated-responses among coral and zooxanthellae in the scleractinian coral Acropora formosa in response to an emerging marine pollutant, the munitions constituent, 1,3,5-trinitro-1,3,5 triazine (RDX; 5 day exposures to 0 (control), 0.5, 0.9, 1.8, 3.7, and 7.2 mg/L, measured in seawater). RDX accumulated readily in coral soft tissues with bioconcentration factors ranging from 1.1 to 1.5. Next-generation sequencing of a normalized meta-transcriptomic library developed for the eukaryotic components of the A. formosa coral holobiont was leveraged to conduct microarray-based global transcript expression analysis of integrated coral/zooxanthellae responses to the RDX exposure. Total differentially expressed transcripts (DET) increased with increasing RDX exposure concentrations as did the proportion of zooxanthellae DET relative to the coral animal. Transcriptional responses in the coral demonstrated higher sensitivity to RDX compared to zooxanthellae where increased expression of gene transcripts coding xenobiotic detoxification mechanisms (i.e. cytochrome P450 and UDP glucuronosyltransferase 2 family) were initiated at the lowest exposure concentration. Increased expression of these detoxification mechanisms was sustained at higher RDX concentrations as well as production of a physical barrier to exposure through a 40% increase in mucocyte density at the maximum RDX exposure. At and above the 1.8 mg/L exposure concentration, DET coding for genes involved in central energy metabolism, including photosynthesis, glycolysis and electron-transport functions, were decreased in zooxanthellae although preliminary data indicated that zooxanthellae densities were not affected. In contrast, significantly increased transcript expression for genes involved in cellular energy production

  18. Equilibrium and response properties of the integrate-and-fire neuron in discrete time

    Directory of Open Access Journals (Sweden)

    Moritz Helias

    2010-01-01

    Full Text Available The integrate-and-fire neuron with exponential postsynaptic potentials is a frequently employed model to study neural networks. Simulations in discrete time still have highest performance at moderate numerical errors, which makes them first choice for long-term simulations of plastic networks. Here we extend the population density approach to investigate how the equilibrium and response properties of the leaky integrate-and-fire neuron are affected by time discretization. We present a novel analytical treatment of the boundary condition at threshold, taking both discretization of time and finite synaptic weights into account. We uncover an increased membrane potential density just below threshold as the decisive property that explains the deviations found between simulations and the classical diffusion approximation. Temporal discretization and finite synaptic weights both contribute to this effect. Our treatment improves the standard formula to calculate the neuron’s equilibrium firing rate. Direct solution of the Markov process describing the evolution of the membrane potential density confirms our analysis and yields a method to calculate the firing rate exactly. Knowing the shape of the membrane potential distribution near threshold enables us to devise the transient response properties of the neuron model to synaptic input. We find a pronounced non-linear fast response component that has not been described by the prevailing continuous time theory for Gaussian white noise input.

  19. Integral transform solutions of dynamic response of a clamped–clamped pipe conveying fluid

    International Nuclear Information System (INIS)

    Gu Jijun; An Chen; Duan Menglan; Levi, Carlos; Su Jian

    2013-01-01

    Highlights: ► Dynamic response of pipe conveying fluid was studied numerically. ► The generalized integral transform technique (GITT) was applied. ► Numerical solutions with automatic global accuracy control were obtained. ► Excellent convergence behavior was shown. ► Modal separation analysis was carried out and the influence of mass ratio was analyzed. - Abstract: Analysis of dynamic response of pipe conveying fluid is an important aspect in nuclear power plant design. In the present paper, dynamic response of a clamped–clamped pipe conveying fluid was solved by the generalized integral transform technique (GITT). The governing partial differential equation was transformed into a set of second-order ordinary differential equations which is then numerically solved by making use of the subroutine DIVPAG from IMSL Library. A thorough convergence analysis was performed to yield sets of reference results of the transverse deflection at different time and spanwise position. We found good agreement between the computed natural frequencies at mode 1–3 and those obtained by previous theoretical study. Besides, modal separation analysis was carried out and the influence of mass ratio on deflection and natural frequencies was qualitatively and quantitatively assessed.

  20. Individual and organizational predictors of the ethicality of graduate students' responses to research integrity issues.

    Science.gov (United States)

    Langlais, Philip J; Bent, Blake J

    2014-12-01

    The development of effective means to enhance research integrity by universities requires baseline measures of individual, programmatic, and institutional factors known to contribute to ethical decision making and behavior. In the present study, master's thesis and Ph.D. students in the fields of biological, health and social sciences at a research extensive university completed a field appropriate measure of research ethical decision making and rated the seriousness of the research issue and importance for implementing the selection response. In addition they were asked to rate their perceptions of the institutional and departmental research climate and to complete a measure of utilitarian and formalistic predisposition. Female students were found to be more ethical in their decision making compared to male students. The research ethical decision measure was found to be related to participants' ethical predisposition and overall perception of organizational and departmental research climate; however, formalism was the only individual predictor to reach statistical significance and none of the individual subscales of the research climate measure were significantly correlated to ethicality. Participants' ratings of the seriousness of the issue were correlated with their ratings of the importance of carrying out their selected response but neither was significantly predictive of the ethicality of their responses. The implications of these findings for the development of more effective training programs and environments for graduate students in research ethics and integrity are discussed.

  1. Climate change, uncertainty, and resilient fisheries: Institutional responses through integrative science

    DEFF Research Database (Denmark)

    Miller, K.; Charles, A.; Barange, M.

    2010-01-01

    This paper explores the importance of a focus on the fundamental goals of resilience and adaptive capacity in the governance of uncertain fishery systems, particularly in the context of climate change. Climate change interacts strongly with fishery systems, and adds to the inherent uncertainty...... that understanding these aspects of fishery systems and fishery governance is valuable even in the absence of climate-induced processes of change, but that attention to climate change both reinforces the need for, and facilitates the move toward, implementation of integrative science for improved fishery governance....... and processes – to support suitable institutional responses, a broader planning perspective, and development of suitable resilience-building strategies. The paper explores how synergies between institutional change and integrative science can facilitate the development of more effective fisheries policy...

  2. INTEGRAL/SPI γ-ray line spectroscopy. Response and background characteristics

    Science.gov (United States)

    Diehl, Roland; Siegert, Thomas; Greiner, Jochen; Krause, Martin; Kretschmer, Karsten; Lang, Michael; Pleintinger, Moritz; Strong, Andrew W.; Weinberger, Christoph; Zhang, Xiaoling

    2018-03-01

    Context. The space based γ-ray observatory INTEGRAL of the European Space Agency (ESA) includes the spectrometer instrument "SPI". This is a coded mask telescope featuring a 19-element Germanium detector array for high-resolution γ-ray spectroscopy, encapsulated in a scintillation detector assembly that provides a veto for background from charged particles. In space, cosmic rays irradiate spacecraft and instruments, which, in spite of the vetoing detectors, results in a large instrumental background from activation of those materials, and leads to deterioration of the charge collection properties of the Ge detectors. Aim. We aim to determine the measurement characteristics of our detectors and their evolution with time, that is, their spectral response and instrumental background. These incur systematic variations in the SPI signal from celestial photons, hence their determination from a broad empirical database enables a reduction of underlying systematics in data analysis. For this, we explore compromises balancing temporal and spectral resolution within statistical limitations. Our goal is to enable modelling of background applicable to spectroscopic studies of the sky, accounting separately for changes of the spectral response and of instrumental background. Methods: We use 13.5 years of INTEGRAL/SPI data, which consist of spectra for each detector and for each pointing of the satellite. Spectral fits to each such spectrum, with independent but coherent treatment of continuum and line backgrounds, provides us with details about separated background components. From the strongest background lines, we first determine how the spectral response changes with time. Applying symmetry and long-term stability tests, we eliminate degeneracies and reduce statistical fluctuations of background parameters, with the aim of providing a self-consistent description of the spectral response for each individual detector. Accounting for this, we then determine how the

  3. The influence of a scaled boundary response on integral system transient behavior

    International Nuclear Information System (INIS)

    Dimenna, R.A.; Kullberg, C.M.

    1989-01-01

    Scaling relationships associated with the thermal-hydraulic response of a closed-loop system are applied to a calculational assessment of a feed-and-bleed recovery in a nuclear reactor integral effects test. The analysis demonstrates both the influence of scale on the system response and the ability of the thermal-hydraulics code to represent those effects. The qualitative response of the fluid is shown to be coupled to the behavior of the bounding walls through the energy equation. The results of the analysis described in this paper influence the determination of computer code applicability. The sensitivity of the code response to scaling variations introduced in the analysis is found to be appropriate with respect to scaling criteria determined from the scaling literature. Differences in the system response associated with different scaling criteria are found to be plausible and easily explained using well-known principles of heat transfer. Therefore, it is concluded that RELAP5/MOD2 can adequately represent the scaled effects of heat transfer boundary conditions of the thermal-hydraulic calculations through the mechanism of communicating walls. The results of the analysis also serve to clarify certain aspects of experiment and facility design

  4. PROFILE: Integrating Stressor and Response Monitoring into a Resource-Based Water-Quality Assessment Framework.

    Science.gov (United States)

    ROUX; KEMPSTER; KLEYNHANS; VAN; DU

    1999-01-01

    / South African water law as well as the country's water resource management policies are currently under review. The Water Law Principles, which were established as part of this review process, indicate a commitment to sustainable development of water resources and the protection of an ecological "reserve." Such policy goals highlight the limitations of traditional and current water-quality management strategies, which rely on stressor monitoring and associated regulation of pollution. The concept of an assimilative capacity is central to the implementation of the current water-quality management approach. Weaknesses inherent in basing water management on the concept of assimilative capacity are discussed. Response monitoring is proposed as a way of addressing some of the weaknesses. Following a global trend, the new policy goals emphasize the need to protect rather than to use the ability of ecosystems to recover from disturbances. This necessitates the adoption of response measurements to quantify ecological condition and monitor ecological change. Response monitoring focuses on properties that are essential to the sustainability of the ecosystem. These monitoring tools can be used to establish natural ranges of ecological change within ecosystems, as well as to quantify conceptually acceptable and unacceptable ranges of change. Through a framework of biological criteria and biological impairment standards, the results of response monitoring can become an integral part of future water resource management strategies in South Africa. KEY WORDS: Stressor monitoring; Response monitoring; Assimilative capacity; Ecosystem stability; Resilience; Biocriteria

  5. Integration of growth factor signals at the c-fos serum response element.

    Science.gov (United States)

    Price, M A; Hill, C; Treisman, R

    1996-04-29

    A transcription factor ternary complex composed of serum response factor (SRF) and a second factor, ternary complex factor (TCF), mediates the response of the c-fos Serum Response Element to growth factors and mitogens. In NIH3T3 fibroblasts, TCF binding is required for transcriptional activation by the SRE in response to activation of the Ras-Raf-ERK pathway. We compared the properties of three members of the TCF family, Elk-1, SAP-1 and SAP-2 (ERP/NET). Although all the proteins contain sequences required for ternary complex formation with SRF, only Elk-1 and SAP-1 appear to interact with the c-fos SRE efficiently in vivo. Each TCF contains a C-terminal activation domain capable of transcriptional activation in response to activation of the Ras-Raf-ERK pathway, and this is dependent on the integrity of S/T-P motifs conserved between all the TCF family members. In contrast, activation of the SRE by whole serum and the mitogenic phospholipid LPA requires SRF binding alone. Constitutively activated members of the Rho subfamily of Ras-like GTPases are also capable of inducing activation of the SRE in the absence of TCF; unlike activated Ras itself, these proteins do not activate the TCFs in NIH3T3 cells. At the SRE, SRF- and TCF-linked signalling pathways act synergistically to potentiate transcription.

  6. An Integrated MCDM Model for Conveyor Equipment Evaluation and Selection in an FMC Based on a Fuzzy AHP and Fuzzy ARAS in the Presence of Vagueness

    Science.gov (United States)

    Nguyen, Huu-Tho; Md Dawal, Siti Zawiah; Nukman, Yusoff; P. Rifai, Achmad; Aoyama, Hideki

    2016-01-01

    The conveyor system plays a vital role in improving the performance of flexible manufacturing cells (FMCs). The conveyor selection problem involves the evaluation of a set of potential alternatives based on qualitative and quantitative criteria. This paper presents an integrated multi-criteria decision making (MCDM) model of a fuzzy AHP (analytic hierarchy process) and fuzzy ARAS (additive ratio assessment) for conveyor evaluation and selection. In this model, linguistic terms represented as triangular fuzzy numbers are used to quantify experts’ uncertain assessments of alternatives with respect to the criteria. The fuzzy set is then integrated into the AHP to determine the weights of the criteria. Finally, a fuzzy ARAS is used to calculate the weights of the alternatives. To demonstrate the effectiveness of the proposed model, a case study is performed of a practical example, and the results obtained demonstrate practical potential for the implementation of FMCs. PMID:27070543

  7. History and development of the tennis equipment

    OpenAIRE

    Horáková, Kateřina

    2007-01-01

    Title: History and development of the tennis equipment. Aim of the work: Process an integral, tabular and synoptic historical development overview of the tennis equipment. This owerview will cover the period since the early beginnings of the game to present days. Methods: Advance work has historical charakter therefore used methods are historiogaphical methods such as chronological method and historical method. Results: Produce tabular description of the tennis equipment by means of reading a...

  8. Development of a multiple-gene-loading method by combining multi-integration system-equipped mouse artificial chromosome vector and CRISPR-Cas9.

    Directory of Open Access Journals (Sweden)

    Kazuhisa Honma

    Full Text Available Mouse artificial chromosome (MAC vectors have several advantages as gene delivery vectors, such as stable and independent maintenance in host cells without integration, transferability from donor cells to recipient cells via microcell-mediated chromosome transfer (MMCT, and the potential for loading a megabase-sized DNA fragment. Previously, a MAC containing a multi-integrase platform (MI-MAC was developed to facilitate the transfer of multiple genes into desired cells. Although the MI system can theoretically hold five gene-loading vectors (GLVs, there are a limited number of drugs available for the selection of multiple-GLV integration. To overcome this issue, we attempted to knock out and reuse drug resistance genes (DRGs using the CRISPR-Cas9 system. In this study, we developed new methods for multiple-GLV integration. As a proof of concept, we introduced five GLVs in the MI-MAC by these methods, in which each GLV contained a gene encoding a fluorescent or luminescent protein (EGFP, mCherry, BFP, Eluc, and Cluc. Genes of interest (GOI on the MI-MAC were expressed stably and functionally without silencing in the host cells. Furthermore, the MI-MAC carrying five GLVs was transferred to other cells by MMCT, and the resultant recipient cells exhibited all five fluorescence/luminescence signals. Thus, the MI-MAC was successfully used as a multiple-GLV integration vector using the CRISPR-Cas9 system. The MI-MAC employing these methods may resolve bottlenecks in developing multiple-gene humanized models, multiple-gene monitoring models, disease models, reprogramming, and inducible gene expression systems.

  9. Integration of midwives into the Quebec health care system. L'Equipe d'Evaluation des Projets-Pilotes Sages-Femmes.

    Science.gov (United States)

    Collin, J; Blais, R; White, D; Demers, A; Desbiens, F

    2000-01-01

    This paper reports on one aspect of the evaluation of the midwifery pilot projects in Quebec: the identification of the professional and organizational factors, as well as the mode of integrating midwives into the maternity care system, that would promote the best outcomes and the autonomy of midwives. The research strategy involved a multiple-case study, in which each midwifery pilot project represented a case. Based on a qualitative approach, the study employed various sources of data: individual interviews and focus groups with key informants, site observations and analyses of written documents. Results show that midwives were poorly integrated into the health care system during the evaluation. Four main reasons were identified: lack of knowledge about the practice of midwifery on the part of other health care providers; deficiencies in the legal and organizational structure of the pilot projects; competition over professional territories; and gaps between the midwives' and other providers' professional cultures. Recommendations are provided to facilitate the integration of midwives into the health care system.

  10. An Integrated Model to Explain How Corporate Social Responsibility Affects Corporate Financial Performance

    Directory of Open Access Journals (Sweden)

    Chin-Shien Lin

    2015-06-01

    Full Text Available The effect of corporate social responsibility (CSR on financial performance has important implications for enterprises, communities, and countries, and the significance of this issue cannot be ignored. Therefore, this paper proposes an integrated model to explain the influence of CSR on financial performance with intellectual capital as a mediator and industry type as a moderator. Empirical results indicate that intellectual capital mediates the relationship between CSR and financial performance, and industry type moderates the direct influence of CSR on financial performance. Such results have critical implications for both academia and practice.

  11. Market integration of flexible demand and DG-RES supply. A new approach for demand response

    International Nuclear Information System (INIS)

    Warmer, C.J.; Hommelberg, M.P.F.; Kamphuis, I.G.; Kok, J.K.

    2007-06-01

    In this paper we discuss the shortcomings of traditional Demand Response programs in an environment in which a large amount of distributed generation is available. An innovative approach is given in which true Customer Site Integration is obtained in the spirit of the liberalized electricity market, by making use of the load flexibility of underlying processes of production and consumption devices. The approach is based on distributed control mechanisms and incorporates new market models for distribution and aggregation costs, load losses, and network constraints

  12. Integration of laser trapping for continuous and selective monitoring of photothermal response of a single microparticle.

    Science.gov (United States)

    Vasudevan, Srivathsan; Chen, George C K; Ahluwalia, Balpreet Singh

    2008-12-01

    Photothermal response (PTR) is an established pump and probe technique for real-time sensing of biological assays. Continuous and selective PTR monitoring is difficult owing to the Brownian motion changing the relative position of the target with respect to the beams. Integration of laser trapping with PTR is proposed as a solution. The proposed method is verified on red polystyrene microparticles. PTR is continuously monitored for 30 min. Results show that the mean relaxation time variation of the acquired signals is less than 5%. The proposed method is then applied to human red blood cells for continuous and selective PTR.

  13. Lessons learned in testing of Safeguards equipment

    International Nuclear Information System (INIS)

    Pepper, Susan; Farnitano, Michael; Carelli, Joseph

    2001-01-01

    Full text: During the 1990s, the IAEA Department of Safeguards began a transition from analog to digital equipment. This included surveillance equipment, seals, NDA measurement systems, and other instruments. The transition to digital equipment was intended to facilitate compatibility between and integration of instruments, remote communication of data, improved data storage, and modernization. Many of the instruments are designed to operate on battery power during loss of facility power, and therefore, are designed to consume minimal power. In 2000, the IAEA experienced a number of failures in digital image surveillance (DIS) equipment. A study of the performance data revealed that the failures occurred in 'high risk' environments where the systems were exposed to neutrons. As a supporter of IAEA equipment development and implementation, the U.S. Support Program worked with the IAEA, the equipment designer, and the equipment manufacturer in special meetings on DIS to determine the cause of the failures. It was as a result of these meetings that single event upset (SEU) was determined to be the root cause of the failures. The meeting participants also identified a list of actions to improve the reliability of DIS systems. As a result of the DIS meetings and the identified actions, the U.S. Support Program approved a request from the IAEA and established Task E.125, 'Remote Monitoring and Unattended Digital Surveillance Systems.' This task is an umbrella task intended to provide a mechanism for response to IAEA needs related to improving the reliability of unattended, remote monitoring and DIS equipment. Subtasks approved under this task include: E.125.1, 'SDIS Software Consolidation and DCM-14 Audit' - This subtask involves the consolidation of a number of individual upgrades to the SDIS and review of the DCM-14 software. As the sponsor of the design of the DCM-14 by Dr. Neumann, the German Support Program is also a participant in this subtask; E.125.2, 'DIS

  14. Forced Responses of the Parametric Vibration System for the Electromechanical Integrated Magnetic Gear

    Directory of Open Access Journals (Sweden)

    Xiu-hong Hao

    2015-01-01

    Full Text Available Considering the magnetic fields modulating in the electromechanical integrated magnetic gear (EIMG, the electromagnetic coupling stiffnesses vary periodically and the expressions are given by the finite element method. The parametric vibration model and the dynamic differential equations are founded. The expressions of forced responses of EIMG system are deduced when the main resonances and the combination resonances occur. And then, the time and frequency responses are figured out. The dynamic characteristics of EIMG system are discussed. The results show that the dominant frequencies in the resonances are always the natural frequency of EIMG system. The relative amplitudes of the components have great difference and the components amplitudes of the main resonances are much bigger than the components amplitudes of the combination resonances. The time-varying meshing stiffness wave between the inner stator and the inner ferromagnetic pole-pieces has little influence on EIMG system.

  15. ABNT NBR ISO 26000 priorities to integrate the social responsibilities in peaceful use of nuclear energy

    Energy Technology Data Exchange (ETDEWEB)

    Biazini Filho, Francisco L.; Sordi, Gian-Maria, E-mail: gian@atomo.com.br, E-mail: Francisco.biazini@usp.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    The aim of this paper is to indicate the priorities in the themes and issues to integrate the social responsibilities (SR) in of the peaceful use of nuclear energy. The ABNT NBR ISO 26000 - Guidance on Social Responsibility{sub (1)}. Social responsibility should be an integral part of core organizational strategy, with assigned responsibilities and accountability at all appropriate levels of the organization. It should be reflected in decision making and considered in implementing activities. The process suggested is: 1 - determining relevance; 2 - determining significance and 3 - establishing priorities for addressing issues. The relevancies of each issue are established for us, in this paper, from the activities of the peaceful use of nuclear energy. For each relevant issue the priority are established and are: Core subject : The environment 6.5: Issue 1 : Prevention of pollution 6.5.3: Offers guidances to recognized authority sources on how to measure, assess, prevent or control the most common forms of pollution, including emissions to air, discharge waters, toxic products, waste management, biological agents, odors, visual pollution, among others. Core subject : The environment 6.5: Issue 2 : Sustainable resource use 6.5.4: Presents a series of actions aimed at the more smart use of resources, including energy efficiency, conservation, access and use of water, and extracting the most efficiency in the use of materials, renewable or not, reusing or recycling these resources whenever possible. Core subject : Community involvement and development 6.8: Issue 6 : Health 6.8.8: The organization must appreciate to eliminate the negative impacts of their activities on people's health, contributing as possible pair increase access to medicines and sanitation, as well as raise awareness about the disease as much as healthy lifestyles. In the next jobs we should consider the following to determine whether an action to address these 3 issues. (author)

  16. ABNT NBR ISO 26000 priorities to integrate the social responsibilities in peaceful use of nuclear energy

    International Nuclear Information System (INIS)

    Biazini Filho, Francisco L.; Sordi, Gian-Maria

    2013-01-01

    The aim of this paper is to indicate the priorities in the themes and issues to integrate the social responsibilities (SR) in of the peaceful use of nuclear energy. The ABNT NBR ISO 26000 - Guidance on Social Responsibility (1) . Social responsibility should be an integral part of core organizational strategy, with assigned responsibilities and accountability at all appropriate levels of the organization. It should be reflected in decision making and considered in implementing activities. The process suggested is: 1 - determining relevance; 2 - determining significance and 3 - establishing priorities for addressing issues. The relevancies of each issue are established for us, in this paper, from the activities of the peaceful use of nuclear energy. For each relevant issue the priority are established and are: Core subject : The environment 6.5: Issue 1 : Prevention of pollution 6.5.3: Offers guidances to recognized authority sources on how to measure, assess, prevent or control the most common forms of pollution, including emissions to air, discharge waters, toxic products, waste management, biological agents, odors, visual pollution, among others. Core subject : The environment 6.5: Issue 2 : Sustainable resource use 6.5.4: Presents a series of actions aimed at the more smart use of resources, including energy efficiency, conservation, access and use of water, and extracting the most efficiency in the use of materials, renewable or not, reusing or recycling these resources whenever possible. Core subject : Community involvement and development 6.8: Issue 6 : Health 6.8.8: The organization must appreciate to eliminate the negative impacts of their activities on people's health, contributing as possible pair increase access to medicines and sanitation, as well as raise awareness about the disease as much as healthy lifestyles. In the next jobs we should consider the following to determine whether an action to address these 3 issues. (author)

  17. Automation of innovative facade systems with integrated technical building equipment under consideration of comfort aspects; Automatisierung innovativer Fassadensysteme mit integrierter technischer Gebaeudeausruestung unter Beruecksichtigung von Behaglichkeitsaspekten

    Energy Technology Data Exchange (ETDEWEB)

    Hasert, Anita; Becker, Martin [Hochschule Biberach (Germany). Inst. fuer Gebaeude- und Energiesysteme (IGE)

    2012-07-01

    Facades are not only a shell of the protected habitats and a boundary between the indoor climate and the environment of buildings. Facades also convert from previously passive elements to active building systems which perform various functions of the room conditioning (heating, cooling, ventilation, lighting, and so on). The associated increased demands on the system integration into facades require new solutions for the planning, implementation and operation of these innovative systems. Within the intelligent handling of increasing complexity, superior automation strategies have to be developed by means of facade automation. These automation strategies have to match the individual functions with each other, and to ensure a building sector comprehensive functionality. Furthermore, another criterion for the design of integrated facade systems is the consideration of the user's feeling with respect to comfort as well as the user's control and user's acceptance. In line with the research project AUTiFAS (= Automation of innovative facade systems), different automation strategies of the facades and room automation are considered on the basis of metrological investigations and simulation analyses. For this purpose, an innovative facade element with a decentralized ventilation unit and an integrated sunshade had to be integrated into a test room initially. The functionality and the constructional tightness of the total test stand had to be verified and matched to the requirements of the tests. With the objective to develop a standardized description of the control and regulation functions of the building sector comprehensive automation strategies, an automation library was developed based on standard structures and forms of representation using a test facade as an example. The standards DIN EN 15232, IEC 61131 as well as the guidelines VDI 3813 and VDI 3814 provide the fundamentals. The developed automation strategies form the basis for the development of

  18. Social Identity Integration, Parental Response, and Psychological Outcomes among Lesbian, Gay, Bisexual, and Queer South Asian Americans

    OpenAIRE

    Kishore, Saanjh Aakash

    2015-01-01

    The goal of this study is to understand how social identities are integrated across domains of identity. Focusing on a population in which cultural norms dictate sexuality behaviors as a condition of ethnic membership, the study examines how South Asian LGBQ Americans integrate their ethnic and sexual orientation identities, and also examines the role of this dual social identity integration in the relationship between the distal stress of parental responses to LGBQ identity, the proximal str...

  19. Evaluating perceptual integration: uniting response-time- and accuracy-based methodologies.

    Science.gov (United States)

    Eidels, Ami; Townsend, James T; Hughes, Howard C; Perry, Lacey A

    2015-02-01

    This investigation brings together a response-time system identification methodology (e.g., Townsend & Wenger Psychonomic Bulletin & Review 11, 391-418, 2004a) and an accuracy methodology, intended to assess models of integration across stimulus dimensions (features, modalities, etc.) that were proposed by Shaw and colleagues (e.g., Mulligan & Shaw Perception & Psychophysics 28, 471-478, 1980). The goal was to theoretically examine these separate strategies and to apply them conjointly to the same set of participants. The empirical phases were carried out within an extension of an established experimental design called the double factorial paradigm (e.g., Townsend & Nozawa Journal of Mathematical Psychology 39, 321-359, 1995). That paradigm, based on response times, permits assessments of architecture (parallel vs. serial processing), stopping rule (exhaustive vs. minimum time), and workload capacity, all within the same blocks of trials. The paradigm introduced by Shaw and colleagues uses a statistic formally analogous to that of the double factorial paradigm, but based on accuracy rather than response times. We demonstrate that the accuracy measure cannot discriminate between parallel and serial processing. Nonetheless, the class of models supported by the accuracy data possesses a suitable interpretation within the same set of models supported by the response-time data. The supported model, consistent across individuals, is parallel and has limited capacity, with the participants employing the appropriate stopping rule for the experimental setting.

  20. Integrated response toward HIV: a health promotion case study from China.

    Science.gov (United States)

    Jiang, Zhen; Wang, Debin; Yang, Sen; Duan, Mingyue; Bu, Pengbin; Green, Andrew; Zhang, Xuejun

    2011-06-01

    Integrated HIV response refers to a formalized, collaborative process among organizations in communities with HIV at-risk populations. It is a both comprehensive and flexible scheme, which may include community-based environment promotion, skill coalition, fund linkage, human resource collaboration and service system jointly for both HIV prevention and control. It enables decisions and actions responds over time. In 1997, the Chinese government developed a 10-year HIV project supported by World Bank Loan (H9-HIV/AIDS/STIs). It was the first integrated STI/HIV intervention project in China and provides a unique opportunity to explore the long-term comprehensive STI/HIV intervention in a low-middle income country setting. Significant outcomes were identified as development and promotion of the national strategic plan and its ongoing implementation; positive knowledge, behavioral and STI/HIV prevalence rate change; and valuable experiences for managing integrated HIV/STI intervention projects. Essential factors for the success of the project and the key tasks for the next step were identified and included well-designed intervention in rural and low economic regions, unified program evaluation framework and real-time information collection and assessment.

  1. Evaluasi Program Corporate Social Responsibility “Organic Integrated System” PT. Pembangkitan Jawa-Bali Unit Pembangkitan Paiton

    OpenAIRE

    Harianto, Ruth Carissa

    2016-01-01

    Penelitian ini dilakukan untuk mengevaluasi program Corporate Social Responsibility “Organic Integrated System” yang dijalankan oleh divisi umum dan CSR PT. Pembangkitan Jawa – Bali Unit Pembangkitan Paiton. Di dalam melaksanakan program Corporate Social Responsibility “Organic Integrated System” ini, PT. Pembangkitan Jawa – Bali Unit Pembangkitan Paiton bekerja sama dengan Lembaga Swadaya Masyarakat Sekola Konang dan Kelompok Suko Tani sebagai publik sasarannya. Penelitian ini menggunakan pe...

  2. Fusion Analytics: A Data Integration System for Public Health and Medical Disaster Response Decision Support

    Science.gov (United States)

    Passman, Dina B.

    2013-01-01

    Objective The objective of this demonstration is to show conference attendees how they can integrate, analyze, and visualize diverse data type data from across a variety of systems by leveraging an off-the-shelf enterprise business intelligence (EBI) solution to support decision-making in disasters. Introduction Fusion Analytics is the data integration system developed by the Fusion Cell at the U.S. Department of Health and Human Services (HHS), Office of the Assistant Secretary for Preparedness and Response (ASPR). Fusion Analytics meaningfully augments traditional public and population health surveillance reporting by providing web-based data analysis and visualization tools. Methods Fusion Analytics serves as a one-stop-shop for the web-based data visualizations of multiple real-time data sources within ASPR. The 24-7 web availability makes it an ideal analytic tool for situational awareness and response allowing stakeholders to access the portal from any internet-enabled device without installing any software. The Fusion Analytics data integration system was built using off-the-shelf EBI software. Fusion Analytics leverages the full power of statistical analysis software and delivers reports to users in a secure web-based environment. Fusion Analytics provides an example of how public health staff can develop and deploy a robust public health informatics solution using an off-the shelf product and with limited development funding. It also provides the unique example of a public health information system that combines patient data for traditional disease surveillance with manpower and resource data to provide overall decision support for federal public health and medical disaster response operations. Conclusions We are currently in a unique position within public health. One the one hand, we have been gaining greater and greater access to electronic data of all kinds over the last few years. On the other, we are working in a time of reduced government spending

  3. Implementation of numerical integration schemes for the simulation of magnetic SMA constitutive response

    International Nuclear Information System (INIS)

    Kiefer, B; Bartel, T; Menzel, A

    2012-01-01

    Several constitutive models for magnetic shape memory alloys (MSMAs) have been proposed in the literature. The implementation of numerical integration schemes, which allow the prediction of constitutive response for general loading cases and ultimately the incorporation of MSMA response into numerical solution algorithms for fully coupled magneto-mechanical boundary value problems, however, has received only very limited attention. In this work, we establish two algorithmic implementations of the internal variable model for MSMAs proposed in (Kiefer and Lagoudas 2005 Phil. Mag. Spec. Issue: Recent Adv. Theor. Mech. 85 4289–329, Kiefer and Lagoudas 2009 J. Intell. Mater. Syst. 20 143–70), where we restrict our attention to pure martensitic variant reorientation to limit complexity. The first updating scheme is based on the numerical integration of the reorientation strain evolution equation and represents a classical predictor–corrector-type general return mapping algorithm. In the second approach, the inequality-constrained optimization problem associated with internal variable evolution is converted into an unconstrained problem via Fischer–Burmeister complementarity functions and then iteratively solved in standard Newton–Raphson format. Simulations are verified by comparison to closed-form solutions for experimentally relevant loading cases. (paper)

  4. Integrated experimental test program on waterhammer pressure pulses and associated structural responses within a feedwater sparger

    International Nuclear Information System (INIS)

    Nurkkala, P.; Hoikkanen, J.

    1997-01-01

    This paper describes the methods and systems as utilized in an integrated experimental thermohydraulic/mechanics analysis test program on waterhammer pressure pulses within a revised feedwater sparger of a Loviisa generation VVER-440-type reactor. This program was carried out in two stages: (1) measurements with a strictly limited set of operating parameters at Loviisa NPP, and (2) measurements with the full set of operating parameters on a test article simulating the revised feedwater sparger. The experiments at Loviisa NPS served as an invaluable source of information on the nature of waterhammer pressure pulses and structural responses. These tests thus helped to set the objectives and formulate the concept for series of tests on a test article to study the water hammer phenomena. The heavily instrumented full size test article of a steam generator feedwater sparger was placed within a pressure vessel simulating the steam generator. The feedwater sparger was subjected to the full range of operating parameters which were to result in waterhammer pressure pulse trains of various magnitudes and duration. Two different designs of revised feedwater sparger were investigated (i.e. 'grounded' and 'with goose neck'). The following objects were to be met within this program: (1) establish the thermohydraulic parameters that facilitate the occurrence of water hammer pressure pulses, (2) provide a database for further analysis of the pressure pulse phenomena, (3) establish location and severity of these water hammer pressure pulses, (4) establish the structural response due to these pressure pulses, (5) provide input data for structural integrity analysis. (orig.)

  5. Experienced speech-language pathologists' responses to ethical dilemmas: an integrated approach to ethical reasoning.

    Science.gov (United States)

    Kenny, Belinda; Lincoln, Michelle; Balandin, Susan

    2010-05-01

    To investigate the approaches of experienced speech-language pathologists (SLPs) to ethical reasoning and the processes they use to resolve ethical dilemmas. Ten experienced SLPs participated in in-depth interviews. A narrative approach was used to guide participants' descriptions of how they resolved ethical dilemmas. Individual narrative transcriptions were analyzed by using the participant's words to develop an ethical story that described and interpreted their responses to dilemmas. Key concepts from individual stories were then coded into group themes to reflect participants' reasoning processes. Five major themes reflected participants' approaches to ethical reasoning: (a) focusing on the well-being of the client, (b) fulfilling professional roles and responsibilities, (c) attending to professional relationships, (d) managing resources, and (e) integrating personal and professional values. SLPs demonstrated a range of ethical reasoning processes: applying bioethical principles, casuistry, and narrative reasoning when managing ethical dilemmas in the workplace. The results indicate that experienced SLPs adopted an integrated approach to ethical reasoning. They supported clients' rights to make health care choices. Bioethical principles, casuistry, and narrative reasoning provided useful frameworks for facilitating health professionals' application of codes of ethics to complex professional practice issues.

  6. Towards strategic stakeholder management? Integrating perspectives on sustainability challenges such as corporate responses to climate change

    International Nuclear Information System (INIS)

    Kolk, A.; Pinkse, J.

    2007-01-01

    The strategic management of corporate sustainability tends to be approached from one theoretical perspective in academic research and publications in mainstream journals simultaneously. In corporate practice, however, a sustainability issue has different dimensions that cannot be captured if only one such lens is taken. The purpose of this article is to develop a more integrated perspective, embedded in a stakeholder view. This paper uses climate change as an example to illustrate how institutional, resource-based, supply chain and stakeholder views are all important to characterize and understand corporate strategic responses to one issue. This is subsequently linked to the climate strategies and related capabilities of companies, reckoning with societal and competitive contexts. Findings - What a corporate climate strategy looks like depends on the type of stakeholders that a company manages more proactively, which is in turn determined by the extent to which these stakeholders control critical resources. While empirical literature usually adopts a particular theoretical perspective, this article has attempted to develop a more integrative approach on corporate responses to climate change

  7. Demand response with locational dynamic pricing to support the integration of renewables

    International Nuclear Information System (INIS)

    Dupont, B.; De Jonghe, C.; Olmos, L.; Belmans, R.

    2014-01-01

    Electricity production from centralised and decentralised renewable energy resources in Europe is gaining significance, resulting in operational challenges in the electricity system. Although these challenges add to the locational and time dependency of the underlying cost of operating the system, this variability in time and location is not reflected in residential tariff schemes. Consequently, residential users are not incentivised to react to varying system conditions and to help the integration of renewable energy resources. Therefore, this paper provides a theoretical framework for designing a locational dynamic pricing scheme. This can be used to assess existing tariff structures for consumption and injection, and can serve as a theoretical background for developing new tariff schemes. Starting from the underlying costs, this paper shows that the potential for locational dynamic pricing depends on the locational and time dependency of its cost drivers. When converting costs into tariffs, the tariff design should be determined. This includes the advance notice of sending tariffs to users, and the length of price blocks and price patterns. This tariff design should find a balance between tariff principles related to costs, practicality and social acceptability on the one hand, and the resulting demand response incentive on the other. - Highlights: • The integration of renewables affects the locational and time dependency of costs. • Locational dynamic pricing reflects cost variability and allows demand response. • A theoretical framework for designing and assessing tariff schemes is proposed. • Tariff variability depends on the locational and time dependency of its cost drivers. • The tariff design should consider the resulting demand response incentive

  8. A comparison of response spectrum and direct integration analysis methods as applied to a nuclear component support structure

    International Nuclear Information System (INIS)

    Bryan, B.J.; Flanders, H.E. Jr.

    1992-01-01

    Seismic qualification of Class I nuclear components is accomplished using a variety of analytical methods. This paper compares the results of time history dynamic analyses of a heat exchanger support structure using response spectrum and time history direct integration analysis methods. Dynamic analysis is performed on the detailed component models using the two methods. A nonlinear elastic model is used for both the response spectrum and direct integration methods. A nonlinear model which includes friction and nonlinear springs, is analyzed using time history input by direct integration. The loads from the three cases are compared

  9. Integration of Synthetic Aperture Radar (SAR) Imagery and Derived Products into Severe Weather Disaster Response

    Science.gov (United States)

    Schultz, L. A.; Molthan, A.; Nicoll, J. B.; Bell, J. R.; Gens, R.; Meyer, F. J.

    2017-12-01

    Disaster response efforts leveraging imagery from NASA, USGS, NOAA, and the European Space Agency (ESA) have continued to expand as satellite imagery and derived products offer an enhanced overview of the affected areas, especially in remote areas where terrain and the scale of the damage can inhibit response efforts. NASA's Short-term Prediction Research and Transition (SPoRT) Center has been supporting the NASA Earth Science Disaster Response Program by providing both optical and SAR imagery products to the NWS and FEMA to assist during domestic response efforts. Although optical imagery has dominated, the availability of ESA's Synthetic Aperture Radar (SAR) data from the Sentinel 1-A/B satellites offers a unique perspective to the damage response community as SAR imagery can be collected regardless of the time of day or the presence of clouds, two major hindrances to the use of satellite optical imagery. Through a partnership with the University of Alaska Fairbanks (UAF) and the collocated Alaska Satellite Facility (ASF), NASA's SAR Distributed Active Archive Center (DAAC), SPoRT has been investigating the use of SAR imagery products to support storm damage surveys conducted by the National Weather Service after any severe weather event. Additionally, products are also being developed and tested for FEMA and the National Guard Bureau. This presentation will describe how SAR data from the Sentinel 1A/B satellites are processed and developed into products. Examples from multiple tornado and hail events will be presented highlighting both the strengths and weaknesses of SAR imagery and how it integrates and compliments more traditional optical imagery collected post-event. Specific case study information from a large hail event in South Dakota and a long track tornado near Clear Lake, Wisconsin will be discussed as well as an overview of the work being done to support FEMA and the National Guard.

  10. Efficient colorimetric pH sensor based on responsive polymer-quantum dot integrated graphene oxide.

    Science.gov (United States)

    Paek, Kwanyeol; Yang, Hyunseung; Lee, Junhyuk; Park, Junwoo; Kim, Bumjoon J

    2014-03-25

    In this paper, we report the development of a versatile platform for a highly efficient and stable graphene oxide (GO)-based optical sensor that exhibits distinctive ratiometric color responses. To demonstrate the applicability of the platform, we fabricated a colorimetric, GO-based pH sensor that responds to a wide range of pH changes. Our sensing system is based on responsive polymer and quantum dot (QD) hybrids integrated on a single GO sheet (MQD-GO), with the GO providing an excellent signal-to-noise ratio and high dispersion stability in water. The photoluminescence emissions of the blue and orange color-emitting QDs (BQDs and OQDs) in MQD-GO can be controlled independently by different pH-responsive linkers of poly(acrylic acid) (PAA) (pKa=4.5) and poly(2-vinylpyridine) (P2VP) (pKa=3.0) that can tune the efficiencies of Förster resonance energy transfer from the BQDs to the GO and from the OQDs to the GO, respectively. As a result, the color of MQD-GO changes from orange to near-white to blue over a wide range of pH values. The detailed mechanism of the pH-dependent response of the MQD-GO sensor was elucidated by measurements of time-resolved fluorescence and dynamic light scattering. Furthermore, the MQD-GO sensor showed excellent reversibility and high dispersion stability in pure water, indicating that our system is an ideal platform for biological and environmental applications. Our colorimetric GO-based optical sensor can be expanded easily to various other multifunctional, GO-based sensors by using alternate stimuli-responsive polymers.

  11. Shipboard and laboratory equipment

    Digital Repository Service at National Institute of Oceanography (India)

    Shyamprasad, M.; Ramaswamy, V.

    The polymetallic nodules occur at an average depth of 4500 m. Adequate equipment and techniques are required for the exploration at such depths. Shipboard and various laboratory equipments for the sampling of polymetallic nodules is described...

  12. Remote handling equipment

    International Nuclear Information System (INIS)

    Clement, G.

    1984-01-01

    After a definition of intervention, problems encountered for working in an adverse environment are briefly analyzed for development of various remote handling equipments. Some examples of existing equipments are given [fr

  13. Population persistence of stream fish in response to environmental change: integrating data and models across space

    Science.gov (United States)

    Letcher, B. H.; Schueller, P.; Bassar, R.; Coombs, J.; Rosner, A.; Sakrejda, K.; Kanno, Y.; Whiteley, A.; Nislow, K. H.

    2013-12-01

    For stream fishes, environmental variation is a key driver of individual body growth/movement/survival and, by extension, population dynamics. Identifying how stream fish respond to environmental variation can help clarify mechanisms responsible for population dynamics and can help provide tools to forecast relative resilience of populations across space. Forecasting dynamics across space is challenging, however, because it can be difficult to conduct enough studies with enough intensity to fully characterize broad-scale population response to environmental change. We have adopted a multi-scale approach, using detailed individual-based studies and analyses (integral projection matrix) to determine sensitivities of population growth to environmental variation combined with broad spatial data and analyses (occupancy and abundance models) to estimate patterns of population response across space. Population growth of brook trout was most sensitive to stream flow in the spring and winter, most sensitive to stream temperature in the fall and sensitive to both flow and temperature in the summer. High flow in the spring and winter had negative effects on population growth while high temperature had a negative effect in the fall. Flow had no effect when it was cold, but a positive effect when it was warm in the summer. Combined with occupancy and abundance models, these data give insight into the spatial structure of resilient populations and can help guide prioritization of management actions.

  14. Integration of multiple cues allows threat-sensitive anti-intraguild predator responses in predatory mites

    Science.gov (United States)

    Walzer, Andreas; Schausberger, Peter

    2013-01-01

    Intraguild (IG) prey is commonly confronted with multiple IG predator species. However, the IG predation (IGP) risk for prey is not only dependent on the predator species, but also on inherent (intraspecific) characteristics of a given IG predator such as its life-stage, sex or gravidity and the associated prey needs. Thus, IG prey should have evolved the ability to integrate multiple IG predator cues, which should allow both inter- and intraspecific threat-sensitive anti-predator responses. Using a guild of plant-inhabiting predatory mites sharing spider mites as prey, we evaluated the effects of single and combined cues (eggs and/or chemical traces left by a predator female on the substrate) of the low risk IG predator Neoseiulus californicus and the high risk IG predator Amblyseius andersoni on time, distance and path shape parameters of the larval IG prey Phytoseiulus persimilis. IG prey discriminated between traces of the low and high risk IG predator, with and without additional presence of their eggs, indicating interspecific threat-sensitivity. The behavioural changes were manifest in distance moved, activity and path shape of IG prey. The cue combination of traces and eggs of the IG predators conveyed other information than each cue alone, allowing intraspecific threat-sensitive responses by IG prey apparent in changed velocities and distances moved. We argue that graded responses to single and combined IG predator cues are adaptive due to minimization of acceptance errors in IG prey decision making. PMID:23750040

  15. Integrating environmental and genetic effects to predict responses of tree populations to climate.

    Science.gov (United States)

    Wang, Tongli; O'Neill, Gregory A; Aitken, Sally N

    2010-01-01

    Climate is a major environmental factor affecting the phenotype of trees and is also a critical agent of natural selection that has molded among-population genetic variation. Population response functions describe the environmental effect of planting site climates on the performance of a single population, whereas transfer functions describe among-population genetic variation molded by natural selection for climate. Although these approaches are widely used to predict the responses of trees to climate change, both have limitations. We present a novel approach that integrates both genetic and environmental effects into a single "universal response function" (URF) to better predict the influence of climate on phenotypes. Using a large lodgepole pine (Pinus contorta Dougl. ex Loud.) field transplant experiment composed of 140 populations planted on 62 sites to demonstrate the methodology, we show that the URF makes full use of data from provenance trials to: (1) improve predictions of climate change impacts on phenotypes; (2) reduce the size and cost of future provenance trials without compromising predictive power; (3) more fully exploit existing, less comprehensive provenance tests; (4) quantify and compare environmental and genetic effects of climate on population performance; and (5) predict the performance of any population growing in any climate. Finally, we discuss how the last attribute allows the URF to be used as a mechanistic model to predict population and species ranges for the future and to guide assisted migration of seed for reforestation, restoration, or afforestation and genetic conservation in a changing climate.

  16. Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.

    Directory of Open Access Journals (Sweden)

    Scott Cukras

    Full Text Available Protein neddylation is involved in a wide variety of cellular processes. Here we show that the DNA damage response is perturbed in cells inactivated with an E2 Nedd8 conjugating enzyme UBE2M, measured by RAD51 foci formation kinetics and cell based DNA repair assays. UBE2M knockdown increases DNA breakages and cellular sensitivity to DNA damaging agents, further suggesting heightened genomic instability and defective DNA repair activity. Investigating the downstream Cullin targets of UBE2M revealed that silencing of Cullin 1, 2, and 4 ligases incurred significant DNA damage. In particular, UBE2M knockdown, or defective neddylation of Cullin 2, leads to a blockade in the G1 to S progression and is associated with delayed S-phase dependent DNA damage response. Cullin 4 inactivation leads to an aberrantly high DNA damage response that is associated with increased DNA breakages and sensitivity of cells to DNA damaging agents, suggesting a DNA repair defect is associated. siRNA interrogation of key Cullin substrates show that CDT1, p21, and Claspin are involved in elevated DNA damage in the UBE2M knockdown cells. Therefore, UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle.

  17. Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.

    Science.gov (United States)

    Cukras, Scott; Morffy, Nicholas; Ohn, Takbum; Kee, Younghoon

    2014-01-01

    Protein neddylation is involved in a wide variety of cellular processes. Here we show that the DNA damage response is perturbed in cells inactivated with an E2 Nedd8 conjugating enzyme UBE2M, measured by RAD51 foci formation kinetics and cell based DNA repair assays. UBE2M knockdown increases DNA breakages and cellular sensitivity to DNA damaging agents, further suggesting heightened genomic instability and defective DNA repair activity. Investigating the downstream Cullin targets of UBE2M revealed that silencing of Cullin 1, 2, and 4 ligases incurred significant DNA damage. In particular, UBE2M knockdown, or defective neddylation of Cullin 2, leads to a blockade in the G1 to S progression and is associated with delayed S-phase dependent DNA damage response. Cullin 4 inactivation leads to an aberrantly high DNA damage response that is associated with increased DNA breakages and sensitivity of cells to DNA damaging agents, suggesting a DNA repair defect is associated. siRNA interrogation of key Cullin substrates show that CDT1, p21, and Claspin are involved in elevated DNA damage in the UBE2M knockdown cells. Therefore, UBE2M is required to maintain genome integrity by activating multiple Cullin ligases throughout the cell cycle.

  18. BP volume reduction equipment

    International Nuclear Information System (INIS)

    Kitamura, Yoshinori; Muroo, Yoji; Hamanaka, Isao

    2003-01-01

    A new type of burnable poison (BP) volume reduction system is currently being developed. Many BP rods, a subcomponent of spent fuel assemblies are discharged from nuclear power reactors. This new system reduces the overall volume of BP rods. The main system consists of BP rod cutting equipment, equipment for the recovery of BP cut pieces, and special transport equipment for the cut rods. The equipment is all operated by hydraulic press cylinders in water to reduce operator exposure to radioactivity. (author)

  19. Response assessment of bevacizumab therapy in GBM with integrated 11C-MET-PET/MRI: a feasibility study.

    Science.gov (United States)

    Deuschl, Cornelius; Moenninghoff, Christoph; Goericke, Sophia; Kirchner, Julian; Köppen, Susanne; Binse, Ina; Poeppel, Thorsten D; Quick, Harald H; Forsting, Michael; Umutlu, Lale; Herrmann, Ken; Hense, Joerg; Schlamann, Marc

    2017-08-01

    The objective of this study was to evaluate the potential of integrated 11C-MET PET/MR for response assessment of relapsed glioblastoma (GBM) receiving bevacizumab treatment. Eleven consecutive patients with relapsed GBM were enrolled for an integrated 11C-MET PET/MRI at baseline and at follow-up. Treatment response for MRI was evaluated according to Response Assessment in Neuro-oncology (RANO) criteria and integrated 11C-MET PET was assessed by the T/N ratio. MRI showed no patient with complete response (CR), six of 11 patients with PR, four of 11 patients with SD, and one of 11 patients with progressive disease (PD). PET revealed metabolic response in five of the six patients with partial response (PR) and in two of the four patients with stable disease (SD), whereas metabolic non-response was detected in one of the six patients with PR, in two of the four patients with SD, and in the one patient with PD. Morphological imaging was predictive for PFS and OS when response was defined as CR, PR, SD, and non-response as PD. Metabolic imaging was predictive when using T/N ratio reduction of >25 as discriminator. Based on the morphologic and metabolic findings of this study a proposal for applying integrated PET/MRI for treatment response in relapsed GBM was developed, which was significantly predictive for PFS and OS (P = 0.010 respectively 0,029, log). This study demonstrates the potential of integrated 11C-MET-PET/MRI for response assessment of GBM and the utility of combined assessment of morphologic and metabolic information with the proposal for assessing relapsed GBM.

  20. Response assessment of bevacizumab therapy in GBM with integrated 11C-MET-PET/MRI: a feasibility study

    Energy Technology Data Exchange (ETDEWEB)

    Deuschl, Cornelius [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University of Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Duisburg (Germany); Moenninghoff, Christoph; Goericke, Sophia; Forsting, Michael; Umutlu, Lale [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); Kirchner, Julian [University Hospital Duesseldorf, Institute of Diagnostic and Interventional Radiology, Duesseldorf (Germany); Koeppen, Susanne [University Hospital Essen, Department of Neurology, Essen (Germany); Binse, Ina; Poeppel, Thorsten D.; Herrmann, Ken [University Hospital Essen, Department of Nuclear Medicine, Essen (Germany); Quick, Harald H. [University of Duisburg-Essen, Erwin L. Hahn Institute for Magnetic Resonance Imaging, Duisburg (Germany); University Hospital Essen, High Field and Hybrid MR Imaging, Essen (Germany); Hense, Joerg [University Hospital Essen, Department of Medical Oncology, West German Cancer Center, Essen (Germany); Schlamann, Marc [University Hospital Essen, Institute of Diagnostic and Interventional Radiology and Neuroradiology, Essen (Germany); University Hospital Giessen, Department of Neuroradiology, Essen (Germany)

    2017-08-15

    The objective of this study was to evaluate the potential of integrated 11C-MET PET/MR for response assessment of relapsed glioblastoma (GBM) receiving bevacizumab treatment. Eleven consecutive patients with relapsed GBM were enrolled for an integrated 11C-MET PET/MRI at baseline and at follow-up. Treatment response for MRI was evaluated according to Response Assessment in Neuro-oncology (RANO) criteria and integrated 11C-MET PET was assessed by the T/N ratio. MRI showed no patient with complete response (CR), six of 11 patients with PR, four of 11 patients with SD, and one of 11 patients with progressive disease (PD). PET revealed metabolic response in five of the six patients with partial response (PR) and in two of the four patients with stable disease (SD), whereas metabolic non-response was detected in one of the six patients with PR, in two of the four patients with SD, and in the one patient with PD. Morphological imaging was predictive for PFS and OS when response was defined as CR, PR, SD, and non-response as PD. Metabolic imaging was predictive when using T/N ratio reduction of >25 as discriminator. Based on the morphologic and metabolic findings of this study a proposal for applying integrated PET/MRI for treatment response in relapsed GBM was developed, which was significantly predictive for PFS and OS (P = 0.010 respectively 0,029, log). This study demonstrates the potential of integrated 11C-MET-PET/MRI for response assessment of GBM and the utility of combined assessment of morphologic and metabolic information with the proposal for assessing relapsed GBM. (orig.)

  1. Integrated outage management: Leveraging utility system assets including GIS and AMR for optimum outage response

    Energy Technology Data Exchange (ETDEWEB)

    Finamore, E. P.

    2004-02-01

    The control of electrical system outages is discussed. The principal argument advanced is that traditional stand-alone methods of outage response will no longer get the job done without utility companies integrating their outage management systems with other system assets such as GIS (geographic information system) and AMR (advanced metering systems). Many meter reading systems, while primarily supporting customer billing, can also provide outage alarm and some are also capable of service restoration notification, which is an invaluable benefit to service operators since it obviates the need for verifying system restoration by labour-intensive on-site visits or customer call-backs. If successfully leveraged, optimization of all utility assets and improvements in labour productivity can results in improved outage management performance gains without affecting performance in other areas.

  2. Western Wind and Solar Integration Study Phase 3 – Frequency Response and Transient Stability

    Energy Technology Data Exchange (ETDEWEB)

    Miller, N. W. [GE Energy Management, Schenectady, NY (United States); Shao, M. [GE Energy Management, Schenectady, NY (United States); Pajic, S. [GE Energy Management, Schenectady, NY (United States); D' Aquila, R. [GE Energy Management, Schenectady, NY (United States)

    2014-12-01

    Power system operators and utilities worldwide have concerns about the impact of high-penetration wind and solar generation on electric grid reliability (EirGrid 2011b, Hydro-Quebec 2006, ERCOT 2010). The stability of North American grids under these conditions is a particular concern and possible impediment to reaching future renewable energy goals. Phase 3 of the Western Wind and Solar Integration Study (WWSIS-3) considers a 33% wind and solar annual energy penetration level that results in substantial changes to the characteristics of the bulk power system, including different power flow patterns, different commitment and dispatch of existing synchronous generation, and different dynamic behavior of wind and solar generation. WWSIS-3 evaluates two specific aspects of fundamental frequency system stability: frequency response and transient stability.

  3. A robust direct-integration method for rotorcraft maneuver and periodic response

    Science.gov (United States)

    Panda, Brahmananda

    1992-01-01

    The Newmark-Beta method and the Newton-Raphson iteration scheme are combined to develop a direct-integration method for evaluating the maneuver and periodic-response expressions for rotorcraft. The method requires the generation of Jacobians and includes higher derivatives in the formulation of the geometric stiffness matrix to enhance the convergence of the system. The method leads to effective convergence with nonlinear structural dynamics and aerodynamic terms. Singularities in the matrices can be addressed with the method as they arise from a Lagrange multiplier approach for coupling equations with nonlinear constraints. The method is also shown to be general enough to handle singularities from quasisteady control-system models. The method is shown to be more general and robust than the similar 2GCHAS method for analyzing rotorcraft dynamics.

  4. The mast cell integrates the splanchnic and systemic inflammatory response in portal hypertension

    Directory of Open Access Journals (Sweden)

    Arias Jorge-Luis

    2007-09-01

    Full Text Available Abstract Portal hypertension is a clinical syndrome that is difficult to study in an isolated manner since it is always associated with a greater or lesser degree of liver functional impairment. The aim of this review is to integrate the complications related to chronic liver disease by using both, the array of mast cell functions and mediators, since they possibly are involved in the pathophysiological mechanisms of these complications. The portal vein ligated rat is the experimental model most widely used to study this syndrome and it has been considered that a systemic inflammatory response is produced. This response is mediated among other inflammatory cells by mast cells and it evolves in three linked pathological functional systems. The nervous functional system presents ischemia-reperfusion and edema (oxidative stress and would be responsible for hyperdynamic circulation; the immune functional system causes tissue infiltration by inflammatory cells, particularly mast cells and bacteria (enzymatic stress and the endocrine functional system presents endothelial proliferation (antioxidative and antienzymatic stress and angiogenesis. Mast cells could develop a key role in the expression of these three phenotypes because their mediators have the ability to produce all the aforementioned alterations, both at the splanchnic level (portal hypertensive enteropathy, mesenteric adenitis, liver steatosis and the systemic level (portal hypertensive encephalopathy. This hypothetical splanchnic and systemic inflammatory response would be aggravated during the progression of the chronic liver disease, since the antioxidant ability of the body decreases. Thus, a critical state is produced, in which the appearance of noxious factors would favor the development of a dedifferentiation process protagonized by the nervous functional system. This system rapidly induces an ischemia-reperfusion phenotype with hydration and salinization of the body (hepatorenal

  5. Plant responses to precipitation in desert ecosystems: integrating functional types, pulses, thresholds, and delays.

    Science.gov (United States)

    Ogle, Kiona; Reynolds, James F

    2004-10-01

    The 'two-layer' and 'pulse-reserve' hypotheses were developed 30 years ago and continue to serve as the standard for many experiments and modeling studies that examine relationships between primary productivity and rainfall variability in aridlands. The two-layer hypothesis considers two important plant functional types (FTs) and predicts that woody and herbaceous plants are able to co-exist in savannas because they utilize water from different soil layers (or depths). The pulse-reserve model addresses the response of individual plants to precipitation and predicts that there are 'biologically important' rain events that stimulate plant growth and reproduction. These pulses of precipitation may play a key role in long-term plant function and survival (as compared to seasonal or annual rainfall totals as per the two-layer model). In this paper, we re-evaluate these paradigms in terms of their generality, strengths, and limitations. We suggest that while seasonality and resource partitioning (key to the two-layer model) and biologically important precipitation events (key to the pulse-reserve model) are critical to understanding plant responses to precipitation in aridlands, both paradigms have significant limitations. Neither account for plasticity in rooting habits of woody plants, potential delayed responses of plants to rainfall, explicit precipitation thresholds, or vagaries in plant phenology. To address these limitations, we integrate the ideas of precipitation thresholds and plant delays, resource partitioning, and plant FT strategies into a simple 'threshold-delay' model. The model contains six basic parameters that capture the nonlinear nature of plant responses to pulse precipitation. We review the literature within the context of our threshold-delay model to: (i) develop testable hypotheses about how different plant FTs respond to pulses; (ii) identify weaknesses in the current state-of-knowledge; and (iii) suggest future research directions that will

  6. DNA double-strand break response in stem cells: mechanisms to maintain genomic integrity.

    Science.gov (United States)

    Nagaria, Pratik; Robert, Carine; Rassool, Feyruz V

    2013-02-01

    Embryonic stem cells (ESCs) represent the point of origin of all cells in a given organism and must protect their genomes from both endogenous and exogenous genotoxic stress. DNA double-strand breaks (DSBs) are one of the most lethal forms of damage, and failure to adequately repair DSBs would not only compromise the ability of SCs to self-renew and differentiate, but will also lead to genomic instability and disease. Herein, we describe the mechanisms by which ESCs respond to DSB-inducing agents such as reactive oxygen species (ROS) and ionizing radiation, compared to somatic cells. We will also discuss whether the DSB response is fully reprogrammed in induced pluripotent stem cells (iPSCs) and the role of the DNA damage response (DDR) in the reprogramming of these cells. ESCs have distinct mechanisms to protect themselves against DSBs and oxidative stress compared to somatic cells. The response to damage and stress is crucial for the maintenance of self-renewal and differentiation capacity in SCs. iPSCs appear to reprogram some of the responses to genotoxic stress. However, it remains to be determined if iPSCs also retain some DDR characteristics of the somatic cells of origin. The mechanisms regulating the genomic integrity in ESCs and iPSCs are critical for its safe use in regenerative medicine and may shed light on the pathways and factors that maintain genomic stability, preventing diseases such as cancer. This article is part of a Special Issue entitled Biochemistry of Stem Cells. Copyright © 2012 Elsevier B.V. All rights reserved.

  7. Distribution transformer lifetime analysis in the presence of demand response and rooftop PV integration

    Directory of Open Access Journals (Sweden)

    Behi Behnaz

    2017-01-01

    Full Text Available Many distribution transformers have already exceeded half of their expected service life of 35 years in the infrastructure of Western Power, the electric distribution company supplying southwest of Western Australia, Australia. Therefore, it is anticipated that a high investment on transformer replacement happens in the near future. However, high renewable integration and demand response (DR are promising resources to defer the investment on infrastructure upgrade and extend the lifetime of transformers. This paper investigates the impact of rooftop photovoltaic (PV integration and customer engagement through DR on the lifetime of transformers in electric distribution networks. To this aim, first, a time series modelling of load, DR and PV is utilised for each year over a planning period. This load model is applied to a typical distribution transformer for which the hot-spot temperature rise is modelled based on the relevant standard. Using this calculation platform, the loss of life and the actual age of distribution transformer are obtained. Then, various scenarios including different levels of PV penetration and DR contribution are examined, and their impacts on the age of transformer are reported. Finally, the equivalent loss of net present value of distribution transformer is formulated and discussed. This formulation gives major benefits to the distribution network planners for analysing the contribution of PV and DR on lifetime extension of the distribution transformer. In addition, the provided model can be utilised in optimal investment analysis to find the best time for the transformer replacement and the associated cost considering PV penetration and DR. The simulation results show that integration of PV and DR within a feeder can significantly extend the lifetime of transformers.

  8. Combined effect of Bacillus coagulans GBI-30, 6086 and HMB supplementation on muscle integrity and cytokine response during intense military training.

    Science.gov (United States)

    Gepner, Yftach; Hoffman, Jay R; Shemesh, Elad; Stout, Jeffrey R; Church, David D; Varanoske, Alyssa N; Zelicha, Hila; Shelef, Ilan; Chen, Yacov; Frankel, Hagai; Ostfeld, Ishay

    2017-07-01

    The purpose of this study was to compare the coadministration of the probiotic Bacillus coagulans GBI-30, 6086 (BC30) with β-hydroxy-β-methylbutyrate (HMB) calcium (CaHMB) to CaHMB alone on inflammatory response and muscle integrity during 40 days of intense military training. Soldiers were randomly assigned to one of two groups: CaHMB with BC30 (CaHMBBC30; n = 9) or CaHMB with placebo (CaHMBPL, n = 9). A third group of participants served as a control (CTL; n = 8). During the first 28 days soldiers were garrisoned on base and participated in the same training tasks. During the final 2 wk soldiers navigated 25-30 km per night in difficult terrain carrying ~35 kg of equipment. All assessments (blood draws and diffusion tensor imaging to assess muscle integrity) were conducted before and ~12 h after final supplement consumption. Analysis of covariance was used to analyze all blood and muscle measures. Significant attenuations were noted in IL-1β, IL-2, IL-6, CX3CL1, and TNF-α for both CaHMBBC30 and CaHMBPL compared with CTL. Plasma IL-10 concentrations were significantly attenuated for CaHMBBC30 compared with CTL only. A significant decrease in apparent diffusion coefficients was also observed for CaHMBBC30 compared with CaHMBPL. Results provide further evidence that HMB supplementation may attenuate the inflammatory response to intense training and that the combination of the probiotic BC30 with CaHMB may be more beneficial than CaHMB alone in maintaining muscle integrity during intense military training. NEW & NOTEWORTHY β-Hydroxy-β-methylbutyrate (HMB) in its free acid form was reported to attenuate inflammation and maintain muscle integrity during military training. However, this formulation was difficult to maintain in the field. In this investigation, soldiers ingested HMB calcium (CaHMB) with Bacillus coagulans (BC30) or CaHMB alone during 40 days of training. Results indicated that CaHMB attenuated the inflammatory response and that BC30 combined with

  9. Ergonomic requirements for the operation of machines and technical equipment

    Directory of Open Access Journals (Sweden)

    Górny Adam

    2017-01-01

    Full Text Available In order to operate machinery and equipment safely, it is critical for the solutions in place to conform to design-related and operating requirements. Design-related requirements are primarily the responsibility of machine designers/developers and manufacturers. Operating requirements should be satisfied by employers, who are responsible for ensuring safe working conditions for their employees. Under applicable laws, machinery and equipment should be designed, produced and then operated without placing excessive loads on workers and in keeping with machine functionality and intended use. One should also ensure that machinery and equipment can be maintained and adjusted without exposing their operators to hazards. Ergonomic criteria are an integral part of such requirements. They ensure that human users and operators of technical equipment are enabled to function properly. Design-related requirements are viewed as a priority safety consideration. While they facilitate the use of technical tools, the actual safety of employees ultimately depends on the satisfaction of specific requirements during operation.

  10. Simulation of Logging-while-drilling Tool Response Using Integral Equation Fast Fourier Transform

    Directory of Open Access Journals (Sweden)

    Sun Xiang-Yang

    2017-01-01

    Full Text Available We rely on the volume integral equation (VIE method for the simulation of loggingwhile- drilling (LWG tool response using the integral equation fast Fourier transform (IE-FFT algorithm to accelerate the computation of the matrix-vector product in the iterative solver. Depending on the virtue of the Toeplitz structure of the interpolation of the Green’s function on the uniform Cartesian grids, this method uses FFT to calculate the matrix-vector multiplication. At the same time, this method reduce the memory requirement and CPU time. In this paper, IEFFT method is first used in the simulation of LWG. Numerical results are presented to demonstrate the accuracy and efficiency of this method. Compared with the Moment of Method (MOM and other fast algorithms, IE-FFT have distinct advantages in the fact of memory requirement and CPU time. In addition, this paper study the truncation, mesh elements, the size of the interpolation grids of IE-FFT and dip formation, and give some conclusion with wide applicability.

  11. Kernel integration scatter model for parallel beam gamma camera and SPECT point source response

    International Nuclear Information System (INIS)

    Marinkovic, P.M.

    2001-01-01

    Scatter correction is a prerequisite for quantitative single photon emission computed tomography (SPECT). In this paper a kernel integration scatter Scatter correction is a prerequisite for quantitative SPECT. In this paper a kernel integration scatter model for parallel beam gamma camera and SPECT point source response based on Klein-Nishina formula is proposed. This method models primary photon distribution as well as first Compton scattering. It also includes a correction for multiple scattering by applying a point isotropic single medium buildup factor for the path segment between the point of scatter an the point of detection. Gamma ray attenuation in the object of imaging, based on known μ-map distribution, is considered too. Intrinsic spatial resolution of the camera is approximated by a simple Gaussian function. Collimator is modeled simply using acceptance angles derived from the physical dimensions of the collimator. Any gamma rays satisfying this angle were passed through the collimator to the crystal. Septal penetration and scatter in the collimator were not included in the model. The method was validated by comparison with Monte Carlo MCNP-4a numerical phantom simulation and excellent results were obtained. The physical phantom experiments, to confirm this method, are planed to be done. (author)

  12. Electrical equipment qualification

    International Nuclear Information System (INIS)

    Farmer, W.S.

    1983-01-01

    Electrical equipment qualification research programs being carried out by CEA, JAERI, and Sandia Laboratories are discussed. Objectives of the program are: (1) assessment of accident simulation methods for electrical equipment qualification testing; lower coarse (2) evaluation of equipment aging and accelerated aging methods; (3) determine radiation dose spectrum to electrical equipment and assess simulation methods for qualification; (4) identify inadequacies in electrical equipment qualification procedures and standards and potential failure modes; and (5) provide data for verifying and improving standards, rules and regulatory guides

  13. On the relative contributions of multisensory integration and crossmodal exogenous spatial attention to multisensory response enhancement.

    Science.gov (United States)

    Van der Stoep, N; Spence, C; Nijboer, T C W; Van der Stigchel, S

    2015-11-01

    Two processes that can give rise to multisensory response enhancement (MRE) are multisensory integration (MSI) and crossmodal exogenous spatial attention. It is, however, currently unclear what the relative contribution of each of these is to MRE. We investigated this issue using two tasks that are generally assumed to measure MSI (a redundant target effect task) and crossmodal exogenous spatial attention (a spatial cueing task). One block of trials consisted of unimodal auditory and visual targets designed to provide a unimodal baseline. In two other blocks of trials, the participants were presented with spatially and temporally aligned and misaligned audiovisual (AV) targets (0, 50, 100, and 200ms SOA). In the integration block, the participants were instructed to respond to the onset of the first target stimulus that they detected (A or V). The instruction for the cueing block was to respond only to the onset of the visual targets. The targets could appear at one of three locations: left, center, and right. The participants were instructed to respond only to lateral targets. The results indicated that MRE was caused by MSI at 0ms SOA. At 50ms SOA, both crossmodal exogenous spatial attention and MSI contributed to the observed MRE, whereas the MRE observed at the 100 and 200ms SOAs was attributable to crossmodal exogenous spatial attention, alerting, and temporal preparation. These results therefore suggest that there may be a temporal window in which both MSI and exogenous crossmodal spatial attention can contribute to multisensory response enhancement. Copyright © 2015 Elsevier B.V. All rights reserved.

  14. Integrated experimental test program on waterhammer pressure pulses and associated structural responses within a feedwater sparger

    Energy Technology Data Exchange (ETDEWEB)

    Nurkkala, P.; Hoikkanen, J. [Imatran Voima Oy, Vantaa (Finland)

    1997-12-31

    This paper describes the methods and systems as utilized in an integrated experimental thermohydraulic/mechanics analysis test program on waterhammer pressure pulses within a revised feedwater sparger of a Loviisa generation VVER-440-type reactor. This program was carried out in two stages: (1) measurements with a strictly limited set of operating parameters at Loviisa NPP, and (2) measurements with the full set of operating parameters on a test article simulating the revised feedwater sparger. The experiments at Loviisa NPS served as an invaluable source of information on the nature of waterhammer pressure pulses and structural responses. These tests thus helped to set the objectives and formulate the concept for series of tests on a test article to study the water hammer phenomena. The heavily instrumented full size test article of a steam generator feedwater sparger was placed within a pressure vessel simulating the steam generator. The feedwater sparger was subjected to the full range of operating parameters which were to result in waterhammer pressure pulse trains of various magnitudes and duration. Two different designs of revised feedwater sparger were investigated (i.e. `grounded` and `with goose neck`). The following objects were to be met within this program: (1) establish the thermohydraulic parameters that facilitate the occurrence of water hammer pressure pulses, (2) provide a database for further analysis of the pressure pulse phenomena, (3) establish location and severity of these water hammer pressure pulses, (4) establish the structural response due to these pressure pulses, (5) provide input data for structural integrity analysis. (orig.). 3 refs.

  15. Integrated experimental test program on waterhammer pressure pulses and associated structural responses within a feedwater sparger

    Energy Technology Data Exchange (ETDEWEB)

    Nurkkala, P; Hoikkanen, J [Imatran Voima Oy, Vantaa (Finland)

    1998-12-31

    This paper describes the methods and systems as utilized in an integrated experimental thermohydraulic/mechanics analysis test program on waterhammer pressure pulses within a revised feedwater sparger of a Loviisa generation VVER-440-type reactor. This program was carried out in two stages: (1) measurements with a strictly limited set of operating parameters at Loviisa NPP, and (2) measurements with the full set of operating parameters on a test article simulating the revised feedwater sparger. The experiments at Loviisa NPS served as an invaluable source of information on the nature of waterhammer pressure pulses and structural responses. These tests thus helped to set the objectives and formulate the concept for series of tests on a test article to study the water hammer phenomena. The heavily instrumented full size test article of a steam generator feedwater sparger was placed within a pressure vessel simulating the steam generator. The feedwater sparger was subjected to the full range of operating parameters which were to result in waterhammer pressure pulse trains of various magnitudes and duration. Two different designs of revised feedwater sparger were investigated (i.e. `grounded` and `with goose neck`). The following objects were to be met within this program: (1) establish the thermohydraulic parameters that facilitate the occurrence of water hammer pressure pulses, (2) provide a database for further analysis of the pressure pulse phenomena, (3) establish location and severity of these water hammer pressure pulses, (4) establish the structural response due to these pressure pulses, (5) provide input data for structural integrity analysis. (orig.). 3 refs.

  16. Baroreflex and neurovascular responses to skeletal muscle mechanoreflex activation in humans: an exercise in integrative physiology.

    Science.gov (United States)

    Drew, Rachel C

    2017-12-01

    Cardiovascular adjustments to exercise resulting in increased blood pressure (BP) and heart rate (HR) occur in response to activation of several neural mechanisms: the exercise pressor reflex, central command, and the arterial baroreflex. Neural inputs from these feedback and feedforward mechanisms integrate in the cardiovascular control centers in the brain stem and modulate sympathetic and parasympathetic neural outflow, resulting in the increased BP and HR observed during exercise. Another specific consequence of the central neural integration of these inputs during exercise is increased sympathetic neural outflow directed to the kidneys, causing renal vasoconstriction, a key reflex mechanism involved in blood flow redistribution during increased skeletal muscle work. Studies in humans have shown that muscle mechanoreflex activation inhibits cardiac vagal outflow, decreasing the sensitivity of baroreflex control of HR. Metabolite sensitization of muscle mechanoreceptors can lead to reduced sensitivity of baroreflex control of HR, with thromboxane being one of the metabolites involved, via greater inhibition of cardiac vagal outflow without affecting baroreflex control of BP or baroreflex resetting. Muscle mechanoreflex activation appears to play a predominant role in causing renal vasoconstriction, both in isolation and in the presence of local metabolites. Limited investigations in older adults and patients with cardiovascular-related disease have provided some insight into how the influence of muscle mechanoreflex activation on baroreflex function and renal vasoconstriction is altered in these populations. However, future research is warranted to better elucidate the specific effect of muscle mechanoreflex activation on baroreflex and neurovascular responses with aging and cardiovascular-related disease. Copyright © 2017 the American Physiological Society.

  17. DNA damage response and spindle assembly checkpoint function throughout the cell cycle to ensure genomic integrity.

    Directory of Open Access Journals (Sweden)

    Katherine S Lawrence

    2015-04-01

    Full Text Available Errors in replication or segregation lead to DNA damage, mutations, and aneuploidies. Consequently, cells monitor these events and delay progression through the cell cycle so repair precedes division. The DNA damage response (DDR, which monitors DNA integrity, and the spindle assembly checkpoint (SAC, which responds to defects in spindle attachment/tension during metaphase of mitosis and meiosis, are critical for preventing genome instability. Here we show that the DDR and SAC function together throughout the cell cycle to ensure genome integrity in C. elegans germ cells. Metaphase defects result in enrichment of SAC and DDR components to chromatin, and both SAC and DDR are required for metaphase delays. During persistent metaphase arrest following establishment of bi-oriented chromosomes, stability of the metaphase plate is compromised in the absence of DDR kinases ATR or CHK1 or SAC components, MAD1/MAD2, suggesting SAC functions in metaphase beyond its interactions with APC activator CDC20. In response to DNA damage, MAD2 and the histone variant CENPA become enriched at the nuclear periphery in a DDR-dependent manner. Further, depletion of either MAD1 or CENPA results in loss of peripherally associated damaged DNA. In contrast to a SAC-insensitive CDC20 mutant, germ cells deficient for SAC or CENPA cannot efficiently repair DNA damage, suggesting that SAC mediates DNA repair through CENPA interactions with the nuclear periphery. We also show that replication perturbations result in relocalization of MAD1/MAD2 in human cells, suggesting that the role of SAC in DNA repair is conserved.

  18. Space Heating Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Rafferty, Kevin D.

    1998-01-01

    The performance evaluation of space heating equipment for a geothermal application is generally considered from either of two perspectives: (a) selecting equipment for installation in new construction, or (b) evaluating the performance and retrofit requirements of an existing system. With regard to new construction, the procedure is relatively straightforward. Once the heating requirements are determined, the process need only involve the selection of appropriately sized hot water heating equipment based on the available water temperature. It is important to remember that space heating equipment for geothermal applications is the same equipment used in non-geothermal applications. What makes geothermal applications unique is that the equipment is generally applied at temperatures and flow rates that depart significantly from traditional heating system design. This chapter presents general considerations for the performance of heating equipment at non-standard temperature and flow conditions, retrofit of existing systems, and aspects of domestic hot water heating.

  19. A construção da integralidade no trabalho cotidiano da equipe saúde da família La construcción de la integralidad en el trabajo cotidiano del equipo de salud familiar The construction of integrality in the daily work of health family team

    Directory of Open Access Journals (Sweden)

    Selma Maria da Fonseca Viegas

    2013-03-01

    Full Text Available Trata-se do recorte de uma tese de doutorado de abordagem qualitativa, delineada pela estratégia de pesquisa Estudo de Casos Múltiplos Holísticos, com objetivo de compreender a construção das práticas de integralidade em saúde no trabalho cotidiano das equipes de Saúde da Família e de gestores de três municípios do Vale do Jequitinhonha-MG. Foram entrevistados 48 trabalhadores das equipes Saúde da Família e de apoio, além dos secretários municipais. Apresenta-se uma das categorias de análise que mostra a importância dada ao trabalho em equipe multiprofissional e o reconhecimento da necessidade do trabalho do outro, isto é, a complementaridade e a interdependência das ações para prestar uma assistência integral e resolutiva. Algumas equipes apresentaram ações interdisciplinares com uso das diferentes habilidades na identificação e resolução dos problemas. Outras convivem com ações individualizadas, mas referem a necessidade de responsabilidade compartilhada nas ações e decisões da equipe para alcançar a integralidade em saúde.Se trata de un recorte de una tesis doctoral de enfoque cualitativo delineada por la estrategia de investigación "Estudio de Casos Múltiples Holísticos", con el fin de comprender la construcción de las prácticas integrales de salud en el trabajo diario de los equipos de salud de la familia y los administradores de tres municipios del Vale de Jequitinhonha (MG. Los entrevistados son 48 trabajadores de los Equipos de Salud de la Familia y de apoyo, además de los secretarios municipales. Se presenta una de las categorías de análisis que evidencia la importancia dada al trabajo en equipo multiprofesional y el reconocimiento de la necesidad del trabajo del otro, es decir, la complementariedad y la interdependencia de las medidas para proporcionar una atención integral y eficaz. Algunos equipos tienen las medidas disciplinarias con el uso de diferentes habilidades para identificar y

  20. Renewal of radiological equipment.

    Science.gov (United States)

    2014-10-01

    In this century, medical imaging is at the heart of medical practice. Besides providing fast and accurate diagnosis, advances in radiology equipment offer new and previously non-existing options for treatment guidance with quite low morbidity, resulting in the improvement of health outcomes and quality of life for the patients. Although rapid technological development created new medical imaging modalities and methods, the same progress speed resulted in accelerated technical and functional obsolescence of the same medical imaging equipment, consequently creating a need for renewal. Older equipment has a high risk of failures and breakdowns, which might cause delays in diagnosis and treatment of the patient, and safety problems both for the patient and the medical staff. The European Society of Radiology is promoting the use of up-to-date equipment, especially in the context of the EuroSafe Imaging Campaign, as the use of up-to-date equipment will improve quality and safety in medical imaging. Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or renewal. This plan should look forward a minimum of 5 years, with annual updates. Teaching points • Radiological equipment has a definite life cycle span, resulting in unavoidable breakdown and decrease or loss of image quality which renders equipment useless after a certain time period.• Equipment older than 10 years is no longer state-of-the art equipment and replacement is essential. Operating costs of older equipment will be high when compared with new equipment, and sometimes maintenance will be impossible if no spare parts are available.• Older equipment has a high risk of failure and breakdown, causing delays in diagnosis and treatment of the patient and safety problems both for the patient and the medical staff.• Every healthcare institution or authority should have a plan for medical imaging equipment upgrade or replacement. This plan should look forward a

  1. Performance monitoring of safeguards equipment

    International Nuclear Information System (INIS)

    Sirisena, K.; Peltoranta, M.; Goussarov, V.; Vodrazka, P.

    1999-01-01

    SGTCS is responsible for monitoring and reporting the performance of the SG equipment. Performance monitoring (PM) has been implemented in most important safeguards equipment operating unattended in nuclear facilities. Inspectors acquire equipment performance data in facilities. After inspection, the data package is submitted to SGTCS for processing and analysis. The performance data is used for identification of systems or components, which should be changed in the field and for identification of modules which, should be diagnosed at HQ in order to determine the cause of failure. Moreover, the performance data is used for preventive maintenance and spares distribution planning, and to provide statistics for official reports and management decision making. An important part of the performance monitoring is reporting. Equipment performance reports contain information about equipment inventory, utilization, failure types, failure distribution, and reliability. Trends in performance are given in graphical form in cases, where past data is available. Reliability estimates such as expected times between failures are provided. The automated reporting tools are obtainable through EMIS database application. (author)

  2. Optimization of integrated chemical-biological degradation of a reactive azo dye using response surface methodology

    Energy Technology Data Exchange (ETDEWEB)

    Sudarjanto, Gatut [Advanced Wastewater Management Centre, The University of Queensland, Qld 4072 (Australia); Keller-Lehmann, Beatrice [Advanced Wastewater Management Centre, The University of Queensland, Qld 4072 (Australia); Keller, Jurg [Advanced Wastewater Management Centre, The University of Queensland, Qld 4072 (Australia)]. E-mail: j.keller@awmc.uq.edu.au

    2006-11-02

    The integrated chemical-biological degradation combining advanced oxidation by UV/H{sub 2}O{sub 2} followed by aerobic biodegradation was used to degrade C.I. Reactive Azo Red 195A, commonly used in the textile industry in Australia. An experimental design based on the response surface method was applied to evaluate the interactive effects of influencing factors (UV irradiation time, initial hydrogen peroxide dosage and recirculation ratio of the system) on decolourisation efficiency and optimizing the operating conditions of the treatment process. The effects were determined by the measurement of dye concentration and soluble chemical oxygen demand (S-COD). The results showed that the dye and S-COD removal were affected by all factors individually and interactively. Maximal colour degradation performance was predicted, and experimentally validated, with no recirculation, 30 min UV irradiation and 500 mg H{sub 2}O{sub 2}/L. The model predictions for colour removal, based on a three-factor/five-level Box-Wilson central composite design and the response surface method analysis, were found to be very close to additional experimental results obtained under near optimal conditions. This demonstrates the benefits of this approach in achieving good predictions while minimising the number of experiments required.

  3. Optimization of integrated chemical-biological degradation of a reactive azo dye using response surface methodology

    International Nuclear Information System (INIS)

    Sudarjanto, Gatut; Keller-Lehmann, Beatrice; Keller, Jurg

    2006-01-01

    The integrated chemical-biological degradation combining advanced oxidation by UV/H 2 O 2 followed by aerobic biodegradation was used to degrade C.I. Reactive Azo Red 195A, commonly used in the textile industry in Australia. An experimental design based on the response surface method was applied to evaluate the interactive effects of influencing factors (UV irradiation time, initial hydrogen peroxide dosage and recirculation ratio of the system) on decolourisation efficiency and optimizing the operating conditions of the treatment process. The effects were determined by the measurement of dye concentration and soluble chemical oxygen demand (S-COD). The results showed that the dye and S-COD removal were affected by all factors individually and interactively. Maximal colour degradation performance was predicted, and experimentally validated, with no recirculation, 30 min UV irradiation and 500 mg H 2 O 2 /L. The model predictions for colour removal, based on a three-factor/five-level Box-Wilson central composite design and the response surface method analysis, were found to be very close to additional experimental results obtained under near optimal conditions. This demonstrates the benefits of this approach in achieving good predictions while minimising the number of experiments required

  4. Integrative Genomic and Proteomic Analysis of the Response of Lactobacillus casei Zhang to Glucose Restriction.

    Science.gov (United States)

    Yu, Jie; Hui, Wenyan; Cao, Chenxia; Pan, Lin; Zhang, Heping; Zhang, Wenyi

    2018-03-02

    Nutrient starvation is an important survival challenge for bacteria during industrial production of functional foods. As next-generation sequencing technology has greatly advanced, we performed proteomic and genomic analysis to investigate the response of Lactobacillus casei Zhang to a glucose-restricted environment. L. casei Zhang strains were permitted to evolve in glucose-restricted or normal medium from a common ancestor over a 3 year period, and they were sampled at 1000, 2000, 3000, 4000, 5000, 6000, 7000, and 8000 generations and subjected to proteomic and genomic analyses. Genomic resequencing data revealed different point mutations and other mutational events in each selected generation of L. casei Zhang under glucose restriction stress. The differentially expressed proteins induced by glucose restriction were mostly related to fructose and mannose metabolism, carbohydrate metabolic processes, lyase activity, and amino-acid-transporting ATPase activity. Integrative proteomic and genomic analysis revealed that the mutations protected L. casei Zhang against glucose starvation by regulating other cellular carbohydrate, fatty acid, and amino acid catabolism; phosphoenolpyruvate system pathway activation; glycogen synthesis; ATP consumption; pyruvate metabolism; and general stress-response protein expression. The results help reveal the mechanisms of adapting to glucose starvation and provide new strategies for enhancing the industrial utility of L. casei Zhang.

  5. The physiology of meditation: a review. A wakeful hypometabolic integrated response.

    Science.gov (United States)

    Jevning, R; Wallace, R K; Beidebach, M

    1992-01-01

    While for centuries a wakeful and tranquil state or experience variously called "samadhi," "pure awareness," or "enlightenment" had been said to be a normal experience and the goal of meditation in Vedic, Buddhist, and Taoist traditions, there was little known about this behavior until recently, when the practice of "transcendental meditation" (TM) became available for study in Western scientific laboratories. Derived from the Vedic tradition, TM is unique because it requires no special circumstances or effort for practice. Based upon a wide spectrum of physiological data on TM, we hypothesize that meditation is an integrated response with peripheral circulatory and metabolic changes subserving increased central nervous activity. Consistent with the subjective description of meditation as a very relaxed but, at the same time, a very alert state, it is likely that such findings during meditation as increased cardiac output, probable increased cerebral blood flow, and findings reminiscent of the "extraordinary" character of classical reports: apparent cessation of CO2 generation by muscle, fivefold plasma AVP elevation, and EEG synchrony play critical roles in this putative response.

  6. Study of developing nuclear fabrication facility's integrated emergency response manual

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Taeh Yeong; Cho, Nam Chan; Han, Seung Hoon; Moon, Jong Han; Lee, Jin Hang [KEPCO, Daejeon (Korea, Republic of); Min, Guem Young; Han, Ji Ah [Dongguk Univ., Daejeon (Korea, Republic of)

    2016-05-15

    Public begin to pay attention to emergency management. Thus, public's consensus on having high level of emergency management system up to advanced country's is reached. In this social atmosphere, manual is considered as key factor to prevent accident or secure business continuity. Therefore, we first define possible crisis at KEPCO Nuclear Fuel (hereinafter KNF) and also make a 'Reaction List' for each crisis situation at the view of information-design. To achieve it, we analyze several country's crisis response manual and then derive component, indicate duties and roles at the information-design point of view. From this, we suggested guideline to make 'Integrated emergency response manual(IERM)'. The manual we used before have following few problems; difficult to applicate at the site, difficult to deliver information. To complement these problems, we searched manual elements from the view of information-design. As a result, we develop administrative manual. Although, this manual could be thought as fragmentary manual because it confined specific several agency/organization and disaster type.

  7. Supply chain responsibilities and the need for an integrative ethic Management in Emerging Economies

    Directory of Open Access Journals (Sweden)

    Lothar Auchter

    2015-03-01

    Full Text Available The economic importance of the Indian Textile and Clothing (T&C industry is unquestioned. It is one of the second largest employment generating industry, after agriculture, with direct employment of over 35 million people. Tamil Nadu accounts for over 65% of the total number spinning units in India and has been reported exploiting young women workers in the spinning and textile units what is called the “Sumangali Scheme”. “Sumangali” in Tamil means ‘happily married woman’. Globalization confronts decision-makers in connection with global conditions in identifying labour standards that can serve as guidelines for corporations producing or outsourcing outside of their home country. The Article shows that in a globalized business world the concept of a conventional corporate ethic system to put all energy into the development of codes of conduct, and ethical audits and sustainability reporting falls short. This applies to industries like the Tamil Nadu textile industry, as there is no clarity with regard to the causal factors and the key players in the supply chain of such a complex social system. The Integrative Social Contract Theory (ISCT allows understanding the problem of Supply-Chain Responsibilities as a contractual relationship that denotes concrete moral responsibilities.

  8. Quantitative techniques for medical equipment maintenance management

    NARCIS (Netherlands)

    Ben Houria, Zeineb; Masmoudi, Malek; Al Hanbali, Ahmad; Khatrouch, Ikram; Masmoudi, Faouzi

    2016-01-01

    The maintenance department in a hospital is responsible for ensuring the safety of medical equipment and their availability while keeping the operation costs minimal. The selection of the best maintenance strategy is a key decision to reduce the equipment downtime, increase the availability, and

  9. Electronic detecting equipment in the Camac standard

    International Nuclear Information System (INIS)

    Basiladze, S.G.

    1981-01-01

    Basic tends of development of electron detecting equipment of modern facilities for experiments in nuclear physics are considered. Special attention is paid to developments of specialized hybrid integrated circuits, specialized processors for selection of events, usage of integrated circuits of memories in detecting units as well as to prospects of developing nuclear electronics standards [ru

  10. Integrating NEPA (National Environmental Policy Act) and CERCLA (Comprehensive Environmental Response, Compensation, and Liability Act) requirements during remedial responses at DOE facilities

    Energy Technology Data Exchange (ETDEWEB)

    Levine, M.B.; Smith, E.D.; Sharples, F.E.; Eddlemon, G.K.

    1990-07-01

    US Department of Energy (DOE) Order 5400.4, issued October 6, 1989, calls for integrating the requirements of the National Environmental Policy Act (NEPA) with those of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) for DOE remedial actions under CERCLA. CERCLA requires that decisions on site remediation be made through a formal process called a Remedial Investigation/Feasibility Study (RI/FS). According to the DOE order, integration is to be accomplished by conducting the NEPA and CERCLA environmental planning and review procedures concurrently. The primary instrument for integrating the processes is to be the RI/FS process, which will be supplemented as needed to meet the procedural and documentational requirements of NEPA. The final product of the integrated process will be a single, integrated set of documents; namely, an RI report and an FS-EIS that satisfy the requirements of both NEPA and CERCLA. The contents of the report include (1) an overview and comparison of the requirements of the two processes; (2) descriptions of the major tasks included in the integrated RI/FS-EIS process; (3) recommended contents for integrated RI/FS-EIS documents; and (4)a discussion of some potential problems in integrating NEPA and CERCLA that fall outisde the scope of the RI/FS-EIS process, with suggestions for resolving some of these problems. 15 refs.

  11. Integrating NEPA [National Environmental Policy Act] and CERCLA [Comprehensive Environmental Response, Compensation, and Liability Act] requirements during remedial responses at DOE facilities

    International Nuclear Information System (INIS)

    Levine, M.B.; Smith, E.D.; Sharples, F.E.; Eddlemon, G.K.

    1990-07-01

    US Department of Energy (DOE) Order 5400.4, issued October 6, 1989, calls for integrating the requirements of the National Environmental Policy Act (NEPA) with those of the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) for DOE remedial actions under CERCLA. CERCLA requires that decisions on site remediation be made through a formal process called a Remedial Investigation/Feasibility Study (RI/FS). According to the DOE order, integration is to be accomplished by conducting the NEPA and CERCLA environmental planning and review procedures concurrently. The primary instrument for integrating the processes is to be the RI/FS process, which will be supplemented as needed to meet the procedural and documentational requirements of NEPA. The final product of the integrated process will be a single, integrated set of documents; namely, an RI report and an FS-EIS that satisfy the requirements of both NEPA and CERCLA. The contents of the report include (1) an overview and comparison of the requirements of the two processes; (2) descriptions of the major tasks included in the integrated RI/FS-EIS process; (3) recommended contents for integrated RI/FS-EIS documents; and (4)a discussion of some potential problems in integrating NEPA and CERCLA that fall outisde the scope of the RI/FS-EIS process, with suggestions for resolving some of these problems. 15 refs

  12. Calculating the price of tanks, vessels and process equipment of petrochemical industry second criteria of integrity and survival remaining of API RP 579 (Fitness for service); Calculo do preco de tanques, vasos e equipamentos de processo da industria petroquimica segundo criterios de integridade e sobrevida remanescente do API RP 579 (Fitness for service)

    Energy Technology Data Exchange (ETDEWEB)

    Morato, Paulo Cesar Vidal Morato [Petroleo Brasileiro S.A. (PETROBRAS), Rio de Janeiro, RJ (Brazil)

    2012-07-01

    By owning many tanks, vessels and process equipment, PETROBRAS has developed the concept of 'Fitness-For-Service' (suitability for use) under the standard API RP 579, i.e. to verify the structural integrity and remaining useful life of equipment in service. In this paper we will discuss how to calculate the remaining useful life of equipment used in accordance with such criteria and with this technical data, calculate the depreciated price. Steps: verification of applicability; surveys of the technical data of the equipment; surveys the minimum thickness of plating equipment over the years; calculation of the average annual rate of corrosion (tc); calculation of the required minimum thickness according to the criteria of API RP 579 (tr); calculation of remaining useful life (nr); calculation of the depreciated price (Vd) equipment. Conclusions: intended for evaluation of tanks price, vessels and process equipment according to API RP 579 concepts. Estimate the remaining useful life of equipment used and calculates the depreciated price. Scientific method based, consistent and robust, due to calculating established the remaining useful life. (author)

  13. Video equipment of tele dosimetry and audio

    International Nuclear Information System (INIS)

    Ojeda R, M.A.; Padilla C, I.

    2007-01-01

    To develop a work in an area with high radiation, it requires of a detailed knowledge of the surroundings work, a communication and effective vision, a near dosimetric control. In a work where the spaces variables and reduced accesses exist, noise that hinders the communication, defendant operative condition, radiation field and taking of decision, it is necessary to have tools that allow a total control of the environment to make opportune and effective decisions, there where the task is developed. Under this elementary concept, it was developed in the Laguna Verde Central a project that it allowed a mechanism, interactive of control in spaces complex; to see, to hear, to speak, to measure. This concept takes to the creation of an equipped system with closed circuit of television, wireless communication systems, tele dosimetry wireless systems, VHS and DVD recording equipment, uninterrupted energy units. The system requires of an electric power socket, and the installation of two cables by CCTV camera. The system is mobilized by a person. He puts on in operation in 5 minutes using a verification list. The concept was developed in the project denominated VETA-1, (Video Equipment of Tele dosimetry and Audio). It is objective of this work to present before the society the development of the VETA-1 tool that conclude in their first prototype in May of the present year. The VETA-1 project arises by a necessity of optimizing dose, it is an ALARA tool, with a countless applications, like it was proven in the 12 recharge stop of the Unit 1. The VETA-1 project integrate a recording system, with the primary end of analyzing in the place where the task is developed the details for an effective and opportune decision, but the resulting information is of utility for the personnel's training and the planning of future works. The VETA-1 system is an ALARA tool of quick response control. (Author)

  14. RETRIEVAL EQUIPMENT DESCRIPTIONS

    International Nuclear Information System (INIS)

    J. Steinhoff

    1997-01-01

    The objective and the scope of this document are to list and briefly describe the major mobile equipment necessary for waste package (WP) retrieval from the proposed subsurface nuclear waste repository at Yucca Mountain. Primary performance characteristics and some specialized design features of the equipment are explained and summarized in the individual subsections of this document. There are no quality assurance requirements or QA controls in this document. Retrieval under normal conditions is accomplished with the same fleet of equipment as is used for emplacement. Descriptions of equipment used for retrieval under normal conditions is found in Emplacement Equipment Descriptions, DI: BCAF00000-01717-5705-00002 (a document in progress). Equipment used for retrieval under abnormal conditions is addressed in this document and consists of the following: (1) Inclined Plane Hauler; (2) Bottom Lift Transporter; (3) Load Haul Dump (LHD) Loader; (4) Heavy Duty Forklift for Emplacement Drifts; (5) Covered Shuttle Car; (6) Multipurpose Vehicle; and (7) Scaler

  15. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    , while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions...... of equality in the three societies. Finally, it shows that family relations play a central role in immigrants’ and refugees’ establishment of a new life in the receiving societies, even though the welfare society takes on many of the social and economic functions of the family....

  16. Electrocoagulation and nanofiltration integrated process application in purification of bilge water using response surface methodology.

    Science.gov (United States)

    Akarsu, Ceyhun; Ozay, Yasin; Dizge, Nadir; Elif Gulsen, H; Ates, Hasan; Gozmen, Belgin; Turabik, Meral

    Marine pollution has been considered an increasing problem because of the increase in sea transportation day by day. Therefore, a large volume of bilge water which contains petroleum, oil and hydrocarbons in high concentrations is generated from all types of ships. In this study, treatment of bilge water by electrocoagulation/electroflotation and nanofiltration integrated process is investigated as a function of voltage, time, and initial pH with aluminum electrode as both anode and cathode. Moreover, a commercial NF270 flat-sheet membrane was also used for further purification. Box-Behnken design combined with response surface methodology was used to study the response pattern and determine the optimum conditions for maximum chemical oxygen demand (COD) removal and minimum metal ion contents of bilge water. Three independent variables, namely voltage (5-15 V), initial pH (4.5-8.0) and time (30-90 min) were transformed to coded values. The COD removal percent, UV absorbance at 254 nm, pH value (after treatment), and concentration of metal ions (Ti, As, Cu, Cr, Zn, Sr, Mo) were obtained as responses. Analysis of variance results showed that all the models were significant except for Zn (P > 0.05), because the calculated F values for these models were less than the critical F value for the considered probability (P = 0.05). The obtained R(2) and Radj(2) values signified the correlation between the experimental data and predicted responses: except for the model of Zn concentration after treatment, the high R(2) values showed the goodness of fit of the model. While the increase in the applied voltage showed negative effects, the increases in time and pH showed a positive effect on COD removal efficiency; also the most effective linear term was found as time. A positive sign of the interactive coefficients of the voltage-time and pH-time systems indicated synergistic effect on COD removal efficiency, whereas interaction between voltage and pH showed an antagonistic

  17. Maintenance program guidelines for programmatic equipment

    International Nuclear Information System (INIS)

    1994-11-01

    The Division Directors at Lawrence Berkeley Laboratory are responsible for implementing a maintenance program for research equipment (also referred to as programmatic equipment) assigned to them. The program must allow maintenance to be accomplished in a manner that promotes operational safety, environmental protection and compliance, and cost effectiveness; that preserves the intended functions of the facilities and equipment; and that supports the programmatic mission of the Laboratory. Programmatic equipment -- such as accelerators, lasers, radiation detection equipment, and glove boxes -- is dedicated specifically to research. Installed equipment, by contrast, includes the mechanical and electrical systems installed as part of basic building construction, equipment essential to the normal functioning of the facility and its intended use. Examples of installed equipment are heating, ventilating, and air conditioning systems; elevators; and communications systems. The LBL Operating and Assurance Program Plan (PUB-3111, Revision 4) requires that a maintenance program be prepared for programmatic equipment and defines the basic maintenance program elements. Such a program of regular, documented maintenance is vital to the safety and quality of research activities. As a part of that support, this document offers guidance to Laboratory organizations for developing their maintenance programs. It clarifies the maintenance requirements of the Operating and Assurance Program (OAP) and presents an approach that, while not the only possibility, can be expected to produce an effective maintenance program for research equipment belonging to the Laboratory's organizations

  18. Data communication equipment

    International Nuclear Information System (INIS)

    Kim, Hak Seon; Lee, Sang Mok

    1998-02-01

    The contents of this book are introduction of data communication on definition, purpose and history, information terminal about data communication system and data transmission system, data transmit equipment of summary, transmission cable, data port, concentrator and front-end processor, audio communication equipment like phones, radio communication equipment of summary on foundation of electromagnetic waves, AM transmitter, AM receiver, FM receiver and FM transmitter, a satellite and mobile communication equipment such as earth station, TT and C and Cellular phone, video telephone and new media apparatus.

  19. The integration of Price Responsive Demand into Regional Transmission Organization (RTO) wholesale power markets and system operations

    International Nuclear Information System (INIS)

    Centolella, Paul

    2010-01-01

    A number of states and utilities are pursuing demand response based on dynamic and time-differentiated retail prices and utility investments in Advanced Metering Infrastructure (AMI), often as part of Smart Grid initiatives. These developments could produce large amounts of Price Responsive Demand, demand that predictably responds to changes in wholesale prices. Price Responsive Demand could provide significant reliability and economic benefits. However, existing RTO tariffs present potential barriers to the development of Price Responsive Demand. Effectively integrating Price Responsive Demand into RTO markets and operations will require changes in demand forecasting, scarcity pricing reform, synchronization of scarcity pricing with capacity markets, tracking voluntary hedging by price responsive loads, and a non-discriminatory approach in curtailments in capacity emergencies. The article describes changes in RTO policies and systems needed incorporate Price Responsive Demand. (author)

  20. Precision Interval Estimation of the Response Surface by Means of an Integrated Algorithm of Neural Network and Linear Regression

    Science.gov (United States)

    Lo, Ching F.

    1999-01-01

    The integration of Radial Basis Function Networks and Back Propagation Neural Networks with the Multiple Linear Regression has been accomplished to map nonlinear response surfaces over a wide range of independent variables in the process of the Modem Design of Experiments. The integrated method is capable to estimate the precision intervals including confidence and predicted intervals. The power of the innovative method has been demonstrated by applying to a set of wind tunnel test data in construction of response surface and estimation of precision interval.

  1. Approximate seismic analysis of piping or equipment mounted on elastoplastic structures

    International Nuclear Information System (INIS)

    Villaverde, R.

    1990-01-01

    A simple approximate procedure is presented to estimate the maximum response of equipment, piping, or any other light secondary system mounted on nonlinear structures subjected to earthquake ground motions. The procedure is based on the consideration of structure and equipment as an integrated combined system, and on a response spectrum method for the analysis of nonlinear multistory structures. It is formulated in terms of the initial dynamic properties of the independent structure and equipment components, and the nonlinear response spectrum of a specified earthquake ground motion. It may be applied to any linear multiple-degree-of-freedom secondary system connected at one or two arbitrary points of a multistory structure. It fully takes into account the interaction between primary and secondary systems and the nonclassical damping character of structure-equipment systems. It is restricted, however, to structures with elastoplastic load-deformation behaviour and to those cases in which the mass of the secondary system is small in comparison with the mass of the structure. Its accuracy is evaluated by means of a comparative study with the numerical integration solutions of a number of idealized systems. In this comparative study, the proposed procedure estimates the numerical integration solutions with an average error of about 2 per cent. (author)

  2. Equipment Reliability Process in Krsko NPP

    International Nuclear Information System (INIS)

    Gluhak, M.

    2016-01-01

    To ensure long-term safe and reliable plant operation, equipment operability and availability must also be ensured by setting a group of processes to be established within the nuclear power plant. Equipment reliability process represents the integration and coordination of important equipment reliability activities into one process, which enables equipment performance and condition monitoring, preventive maintenance activities development, implementation and optimization, continuous improvement of the processes and long term planning. The initiative for introducing systematic approach for equipment reliability assuring came from US nuclear industry guided by INPO (Institute of Nuclear Power Operations) and by participation of several US nuclear utilities. As a result of the initiative, first edition of INPO document AP-913, 'Equipment Reliability Process Description' was issued and it became a basic document for implementation of equipment reliability process for the whole nuclear industry. The scope of equipment reliability process in Krsko NPP consists of following programs: equipment criticality classification, preventive maintenance program, corrective action program, system health reports and long-term investment plan. By implementation, supervision and continuous improvement of those programs, guided by more than thirty years of operating experience, Krsko NPP will continue to be on a track of safe and reliable operation until the end of prolonged life time. (author).

  3. Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data

    Science.gov (United States)

    Koleti, Amar; Terryn, Raymond; Stathias, Vasileios; Chung, Caty; Cooper, Daniel J; Turner, John P; Vidović, Dušica; Forlin, Michele; Kelley, Tanya T; D’Urso, Alessandro; Allen, Bryce K; Torre, Denis; Jagodnik, Kathleen M; Wang, Lily; Jenkins, Sherry L; Mader, Christopher; Niu, Wen; Fazel, Mehdi; Mahi, Naim; Pilarczyk, Marcin; Clark, Nicholas; Shamsaei, Behrouz; Meller, Jarek; Vasiliauskas, Juozas; Reichard, John; Medvedovic, Mario; Ma’ayan, Avi; Pillai, Ajay

    2018-01-01

    Abstract The Library of Integrated Network-based Cellular Signatures (LINCS) program is a national consortium funded by the NIH to generate a diverse and extensive reference library of cell-based perturbation-response signatures, along with novel data analytics tools to improve our understanding of human diseases at the systems level. In contrast to other large-scale data generation efforts, LINCS Data and Signature Generation Centers (DSGCs) employ a wide range of assay technologies cataloging diverse cellular responses. Integration of, and unified access to LINCS data has therefore been particularly challenging. The Big Data to Knowledge (BD2K) LINCS Data Coordination and Integration Center (DCIC) has developed data standards specifications, data processing pipelines, and a suite of end-user software tools to integrate and annotate LINCS-generated data, to make LINCS signatures searchable and usable for different types of users. Here, we describe the LINCS Data Portal (LDP) (http://lincsportal.ccs.miami.edu/), a unified web interface to access datasets generated by the LINCS DSGCs, and its underlying database, LINCS Data Registry (LDR). LINCS data served on the LDP contains extensive metadata and curated annotations. We highlight the features of the LDP user interface that is designed to enable search, browsing, exploration, download and analysis of LINCS data and related curated content. PMID:29140462

  4. The Unfolded Protein Response Is Induced by the Cell Wall Integrity Mitogen-activated Protein Kinase Signaling Cascade and Is Required for Cell Wall Integrity in Saccharomyces cerevisiae

    OpenAIRE

    Scrimale, Thomas; Didone, Louis; de Mesy Bentley, Karen L.; Krysan, Damian J.

    2009-01-01

    The yeast cell wall is an extracellular structure that is dependent on secretory and membrane proteins for its construction. We investigated the role of protein quality control mechanisms in cell wall integrity and found that the unfolded protein response (UPR) and, to a lesser extent, endoplasmic reticulum (ER)-associated degradation (ERAD) pathways are required for proper cell wall construction. Null mutation of IRE1, double mutation of ERAD components (hrd1Δ and ubc7Δ) and ire1Δ, or expres...

  5. Equipment qualification research program: program plan

    International Nuclear Information System (INIS)

    Dong, R.G.; Smith, P.D.

    1982-01-01

    The Lawrence Livermore National Laboratory (LLNL) under the sponsorship of the US Nuclear Regulatory Commission (NRC) has developed this program plan for research in equipment qualification (EQA). In this report the research program which will be executed in accordance with this plan will be referred to as the Equipment Qualification Research Program (EQRP). Covered are electrical and mechanical equipment under the conditions described in the OBJECTIVE section of this report. The EQRP has two phases; Phase I is primarily to produce early results and to develop information for Phase II. Phase I will last 18 months and consists of six projects. The first project is program management. The second project is responsible for in-depth evaluation and review of EQ issues and EQ processes. The third project is responsible for detailed planning to initiate Phase II. The remaining three projects address specific equipment; i.e., valves, electrical equipment, and a pump

  6. WISE-2005: Integrative cardiovascular responses with LBNP during 60-day bed rest in women

    Science.gov (United States)

    Hughson, R. L.; Kerbeci, P.; Arbeille, P.; Mattar, L.; Shoemaker, J. K.

    2005-08-01

    During 2005, 24 women will take part in the Women International Space-simulation for Exploration (WISE). In this paper we report on the first phase that studied 4 Exercise (EX+LBNP), 4 nutrition (NUT), and 4 no countermeasure control (CON) subjects. The EX+LBNP group completed regular exercise on a treadmill inside LBNP, flywheel resistive exercise and static periods of LBNP, and had recovery days. The NUT group received daily protein supplements. Integrative cardiovascular responses were obtained and here we report data for heart rate during LBNP, blood volume and angiotensin II. LBNP was applied at 0, -10, -20 and -30 mmHg for 2-minutes for each stage. Blood was sampled pre- bed rest and on HDT-60. After 60-days head down bed rest, HR in the CON group increased by 6.1±2.8 bpm at rest and by 20.7±5.0 bpm at -30 mmHg LBNP. The EX+LBNP group had increases of 3.6±5.6 and 11.6±5.4 bpm, while the NUT group HR increased 2.6±3.1 and 9.4±3.6 bpm. The EX+LBNP group had almost no change in blood volume or plasma angiotensin II from pre-bed rest to HDT60, while both the CON and NUT groups had larger increases in plasma volume and almost double concentrations of angiotensin II. These data show a positive effect in the EX+LBNP group on the heart rate response as well as an unexpected possible benefit in the NUT group. Further studies are required to confirm possible cardiovascular benefits of the protein supplement.

  7. Response statistics of rotating shaft with non-linear elastic restoring forces by path integration

    Science.gov (United States)

    Gaidai, Oleg; Naess, Arvid; Dimentberg, Michael

    2017-07-01

    Extreme statistics of random vibrations is studied for a Jeffcott rotor under uniaxial white noise excitation. Restoring force is modelled as elastic non-linear; comparison is done with linearized restoring force to see the force non-linearity effect on the response statistics. While for the linear model analytical solutions and stability conditions are available, it is not generally the case for non-linear system except for some special cases. The statistics of non-linear case is studied by applying path integration (PI) method, which is based on the Markov property of the coupled dynamic system. The Jeffcott rotor response statistics can be obtained by solving the Fokker-Planck (FP) equation of the 4D dynamic system. An efficient implementation of PI algorithm is applied, namely fast Fourier transform (FFT) is used to simulate dynamic system additive noise. The latter allows significantly reduce computational time, compared to the classical PI. Excitation is modelled as Gaussian white noise, however any kind distributed white noise can be implemented with the same PI technique. Also multidirectional Markov noise can be modelled with PI in the same way as unidirectional. PI is accelerated by using Monte Carlo (MC) estimated joint probability density function (PDF) as initial input. Symmetry of dynamic system was utilized to afford higher mesh resolution. Both internal (rotating) and external damping are included in mechanical model of the rotor. The main advantage of using PI rather than MC is that PI offers high accuracy in the probability distribution tail. The latter is of critical importance for e.g. extreme value statistics, system reliability, and first passage probability.

  8. Climate-smart technologies. Integrating renewable energy and energy efficiency in mitigation and adaptation responses

    Energy Technology Data Exchange (ETDEWEB)

    Leal Filho, Walter; Mannke, Franziska; Schulte, Veronika [Hamburg Univ. of Applied Sciences (Germany). Faculty of Life Sciences; Mohee, Romeela; Surroop, Dinesh (eds.) [Mauritius Univ., Reduit (Mauritius). Chemical and Environmental Engineering Dept.

    2013-11-01

    Explores the links between climate change and technologies. Relates to the links between renewable energy and climate change. Documents and promotes a collection of experiences from island nations. Has a strong international focus and value to developing countries. The book addresses the perceived need for a publication with looks at both, climate smart technologies and the integration of renewable energy and energy efficiency in mitigation and adaptation responses. Based on a set of papers submitted as part of the fifth on-line climate conference (CLIMATE 2012) and a major conference on renewable energy on island States held in Mauritius in 2012, the book provides a wealth of information on climate change strategies and the role of smart technologies. The book has been produced in the context of the project ''Small Developing Island Renewable Energy Knowledge and Technology Transfer Network'' (DIREKT), funded by the ACP Science and Technology Programme, an EU programme for cooperation between the European Union and the ACP region.

  9. The Role Of Grenelle II In Corporate Social Responsibility Integrated Reporting

    Directory of Open Access Journals (Sweden)

    Radoslaw Wolniak

    2013-12-01

    Full Text Available There is in the paper, the analysis of the Grenelle II act from Corporate Social Responsibility reporting point of view. France has long been an important global champion of corporate sustainability reporting. While this trend has advanced the integration of CSR into business practices, the increasing number of regulations has also made it more complicated and costly for international companies to create reports that fulfill the differing requirements of each foreign law. The Grenelle 2 law adopted in July 2010, implements the Grenelle 1 goals. It sets specific objectives, strategic, incentives and regulations. This Act aims at forcing companies to progress in reporting their environmental and social information: there is no sanction (such as fines, requirements are on a “comply or explain” basis and the implementation is progressive. The main advantage of such an Grenelle II Act is a beginning and will have to be rewritten and improved, taking into account the international movement – is to shift minds regarding CSR. CSR and extra-financial information has nothing to do with communication anymore: it is clearly a strategic and management process, facilitated by the reporting process.

  10. Integrative response of plant mitochondrial electron transport chain to nitrogen source.

    Science.gov (United States)

    Hachiya, Takushi; Noguchi, Ko

    2011-02-01

    Nitrogen (N) availability is widely known as a determinant of plant growth and respiration rate. However, less attention has been paid to the effect of the type of N source (nitrate, nitrite or ammonium) on the respiratory system. This review summarizes the latest findings on this topic, with an emphasis on the effect of ammonium and nitric oxide (NO) on the respiratory system, and the physiological role of alternative oxidase (AOX). First, concentrated ammonium has been found to increase plant respiration rate (ammonium-dependent respiratory increase, ARI). We will introduce two hypotheses to explain ARI, futile ammonium cycling and excess reducing equivalents, and verify the validity of each hypothesis. We suggest that these two hypotheses are not necessarily mutually exclusive. Second, gene expression of AOX is suppressed when N is predominately available as nitrate instead of ammonium. We will discuss possible signaling pathways leading to this expression pattern. Third, while AOX expression is induced by NO, AOX activity itself is insensitive to NO. In contrast, activity of cytochrome c oxidase (COX) is sensitive to NO. We outline the NO production pathway, focusing on nitrite-dependent NO production, and discuss the physiological significance of the fact that AOX activity is insensitive to NO. Finally, this review aims to build an integrated scheme of the respiratory response to the type of N source, considering leaves in high light conditions or hypoxic roots.

  11. Materials and noncoplanar mesh designs for integrated circuits with linear elastic responses to extreme mechanical deformations.

    Science.gov (United States)

    Kim, Dae-Hyeong; Song, Jizhou; Choi, Won Mook; Kim, Hoon-Sik; Kim, Rak-Hwan; Liu, Zhuangjian; Huang, Yonggang Y; Hwang, Keh-Chih; Zhang, Yong-wei; Rogers, John A

    2008-12-02

    Electronic systems that offer elastic mechanical responses to high-strain deformations are of growing interest because of their ability to enable new biomedical devices and other applications whose requirements are impossible to satisfy with conventional wafer-based technologies or even with those that offer simple bendability. This article introduces materials and mechanical design strategies for classes of electronic circuits that offer extremely high stretchability, enabling them to accommodate even demanding configurations such as corkscrew twists with tight pitch (e.g., 90 degrees in approximately 1 cm) and linear stretching to "rubber-band" levels of strain (e.g., up to approximately 140%). The use of single crystalline silicon nanomaterials for the semiconductor provides performance in stretchable complementary metal-oxide-semiconductor (CMOS) integrated circuits approaching that of conventional devices with comparable feature sizes formed on silicon wafers. Comprehensive theoretical studies of the mechanics reveal the way in which the structural designs enable these extreme mechanical properties without fracturing the intrinsically brittle active materials or even inducing significant changes in their electrical properties. The results, as demonstrated through electrical measurements of arrays of transistors, CMOS inverters, ring oscillators, and differential amplifiers, suggest a valuable route to high-performance stretchable electronics.

  12. Integrating a relaxation response-based curriculum into a public high school in Massachusetts.

    Science.gov (United States)

    Foret, Megan M; Scult, Matthew; Wilcher, Marilyn; Chudnofsky, Rana; Malloy, Laura; Hasheminejad, Nicole; Park, Elyse R

    2012-04-01

    Academic and societal pressures result in U.S. high school students feeling stressed. Stress management and relaxation interventions may help students increase resiliency to stress and overall well-being. The objectives of this study were to examine the feasibility (enrollment, participation and acceptability) and potential effectiveness (changes in perceived stress, anxiety, self-esteem, health-promoting behaviors, and locus of control) of a relaxation response (RR)-based curriculum integrated into the school day for high school students. The curriculum included didactic instruction, relaxation exercises, positive psychology, and cognitive restructuring. The intervention group showed significantly greater improvements in levels of perceived stress, state anxiety, and health-promoting behaviors when compared to the wait list control group. The intervention appeared most useful for girls in the intervention group. The results suggest that several modifications may increase the feasibility of using this potentially effective intervention in high schools. Copyright © 2011 The Foundation for Professionals in Services for Adolescents. Published by Elsevier Ltd. All rights reserved.

  13. Electronic equipment for spectrometric data processing

    International Nuclear Information System (INIS)

    Antonov, L.J.; Trenev, A.M.; Todorova, E.I.; Dimitrov, V.D.

    1978-01-01

    Electronic equipment carrying out logical operations and a full set of the arithmetic operations was developed for spectrometric data processing. The flowsheet of the computing part of the device, made on the basis of a specialized integral circuit, is given. The device includes input registers, multiplexor, matrix commutator, arithmetic unit and indication unit. The equipment is rated to carry out calculations according to comparatively complex formulae in several seconds

  14. Cooling of electronic equipment

    DEFF Research Database (Denmark)

    A. Kristensen, Anders Schmidt

    2003-01-01

    Cooling of electronic equipment is studied. The design size of electronic equipment decrease causing the thermal density to increase. This affect the cooling which can cause for example failures of critical components due to overheating or thermal induced stresses. Initially a pin fin heat sink...

  15. Capital Equipment Replacement Decisions

    OpenAIRE

    Batterham, Robert L.; Fraser, K.I.

    1995-01-01

    This paper reviews the literature on the optimal replacement of capital equipment, especially farm machinery. It also considers the influence of taxation and capital rationing on replacement decisions. It concludes that special taxation provisions such as accelerated depreciation and investment allowances are unlikely to greatly influence farmers' capital equipment replacement decisions in Australia.

  16. Establishment of nuclear equipment qualification system

    International Nuclear Information System (INIS)

    Joo, Po Kook; Lim, Nam Jin; Lee, Young Gun

    2003-04-01

    This study is carried out by KEARI(Korea Atomic Energy Research Institute) as the lead organization in cooperation with KIMM(Korea Institute of Machinery and Materials), KTL(Korea Testing Laboratory) and KRISS(Korea Research Institute of Standards and Science) to construct a basis of efficient management of nuclear equipment qualification business by expanding test equipment of each of participating organization, and developing qualification technologies. As for KIMM, control system of large scale shaker was replaced with advanced system, and LOCA(Loss of Coolant Accident) test facility was installed. KTL is now capable of conducting seismic tests of nuclear I and C as a result of installation of seismic test equipment during the first two project years. KRISS participated in the Project with a view to have large scale EMI test equipment and related technologies. In parallel with expansion of test equipment, a industrial-educational-research cooperation committee, as an intermediate step toward integrated equipment qualification system to maximize the usage of test equipment, was established and cooperation methods were investigated. As a result, Korea Nuclear Equipment Qualification Association, an corporate juridical person, was established. Research on development of thermal and radiation aging test technology of nuclear materials was carried out by Hanyang University and SECO(Saehan Engineering and Qualification Co., Ltd.). Integrated Equipment Qualification Database was developed which contains material test data, equipment qualification data and other EQ related informations. Standard qualification procedures were developed in order for test laboratories and manufacturers to establish design requirements and to efficiently perform tests

  17. Towards a strengthening of inspections carried out on pressurised equipment and pipework..

    International Nuclear Information System (INIS)

    Noel, St.

    2010-01-01

    Following the fast presidential election, a major restructuring of the administrative landscape was set in motion. Tasks that historically were the responsibility of the Ministry of Industry are now carried out by the Ministry of Sustainable Development, which in particular is responsible for the whole policy to do with the prevention of technological risks. The General Directorate for the Prevention of Risks (Direction generale de la prevention des risques (DGPR)) of this ministry is now responsible for controlling technological risks, opening up new perspectives in terms of managing accidental risks and offering a new opportunity for an 'integrated' approach, making it possible to deal with an industrial installation in all its facets. Within the DGPR, the Office for the Safety of Industrial Equipment (bureau de la securite des equipements industriels (BSEI)) is responsible for the safety of pressurised equipment, as well as pipes carrying gas, inflammable liquids and chemical products. After a quick presentation of the inspections carried out on this equipment, issues to do with their safety will be dealt with and in particular: - the suitability of inspections carried out in the tight of faults that are likely to occur and develop in the structures; - control of ageing; - management of the quality of new equipment. (author)

  18. From Idea to Action: Promoting Responsible Management Education through a Semester-Long Academic Integrity Learning Project

    Science.gov (United States)

    Lavine, Marc H.; Roussin, Christopher J.

    2012-01-01

    The authors describe a semester-long action-learning project where undergraduate or graduate management students learn about ethics, responsibility, and organizational behavior by examining the policy of their college or university that addresses academic integrity. Working in teams, students adopt a stakeholder management approach as they make…

  19. DEVELOPMENT OF SOCIAL RESPONSIBILITY IN MOLDOVAN ENTERPRISES AS A STRATEGIC OBJECTIVE OF INTEGRATION IN THE EUROPEAN COMMUNITY

    Directory of Open Access Journals (Sweden)

    Silvia BUCIUSCAN

    2013-02-01

    Full Text Available Socio-economic integration of the Republic of Moldova into the European Community may be held by the companies to achieve concrete measures in order to ensure the effective functioning of the international standards of quality management, social responsibility and environmental management ISO 9000 series, SA 800 and ISO 14000.

  20. Development of social responsibility In moldovan enterprises as a strategic objective of integration in the european community

    Directory of Open Access Journals (Sweden)

    Sendrea Mariana

    2013-02-01

    Full Text Available Socio-economic integration of the Republic of Moldova into the European Community may be held by the companies to achieve concrete measures in order to ensure the effective functioning of the international standards of quality management, social responsibility and environmental management ISO 9000 series, SA 800 and ISO 14000.

  1. Escherichia coli under Ionic Silver Stress: An Integrative Approach to Explore Transcriptional, Physiological and Biochemical Responses.

    Directory of Open Access Journals (Sweden)

    Claire Saulou-Bérion

    Full Text Available For a better understanding of the systemic effect of sub-lethal micromolar concentrations of ionic silver on Escherichia coli, we performed a multi-level characterization of cells under Ag+-mediated stress using an integrative biology approach combining physiological, biochemical and transcriptomic data. Physiological parameters, namely bacterial growth and survival after Ag+ exposure, were first quantified and related to the accumulation of intracellular silver, probed for the first time by nano secondary ion mass spectroscopy at sub-micrometer lateral resolution. Modifications in E. coli biochemical composition were evaluated under Ag+-mediated stress by in situ synchrotron Fourier-transform infrared microspectroscopy and a comprehensive transcriptome response was also determined. Using multivariate statistics, correlations between the physiological parameters, the extracellular concentration of AgNO3 and the intracellular silver content, gene expression profiles and micro-spectroscopic data were investigated. We identified Ag+-dependent regulation of gene expression required for growth (e.g. transporter genes, transcriptional regulators, ribosomal proteins, for ionic silver transport and detoxification (e.g. copA, cueO, mgtA, nhaR and for coping with various types of stress (dnaK, pspA, metA,R, oxidoreductase genes. The silver-induced shortening of the acyl chain of fatty acids, mostly encountered in cell membrane, was highlighted by microspectroscopy and correlated with the down-regulated expression of genes involved in fatty acid transport (fadL and synthesis/modification of lipid A (lpxA and arnA. The increase in the disordered secondary structure of proteins in the presence of Ag+ was assessed through the conformational shift shown for amides I and II, and further correlated with the up-regulated expression of peptidase (hfq and chaperone (dnaJ, and regulation of transpeptidase expression (ycfS and ycbB. Interestingly, as these

  2. Making petroleum equipment safe, a priority

    International Nuclear Information System (INIS)

    1999-01-01

    Changes to the 'Act respecting the use of petroleum products' have been announced effective May 1, 1999. The changes have been made to reduce problems which can be attributed to petroleum product leaks. The new regulations will make owners and users of petroleum equipment, including underground and above-ground storage equipment and commercial storage tanks, more accountable for the use of their own equipment. The emphasis in the new regulations is based upon the storage capacity of petroleum equipment and the risks associated with this equipment, rather than the on the activities of the owners concerned. Accordingly, the new regulations call for stricter requirements for high-risk equipment, a private equipment inspection plan, a two-year operating permit, replacing the current permits and certificates, a tariff structure based on the risks associated with the equipment, and deregulation of commercial activities involving petroleum products that require no equipment. Additionally, the amendments to the Act transfer responsibility for administration to the Regie du batiment and to the Ministere des Transports. Details of each of these changes are explained

  3. Age-related reduction of adaptive brain response during semantic integration is associated with gray matter reduction.

    Directory of Open Access Journals (Sweden)

    Zude Zhu

    Full Text Available While aging is associated with increased knowledge, it is also associated with decreased semantic integration. To investigate brain activation changes during semantic integration, a sample of forty-eight 25-75 year-old adults read sentences with high cloze (HC and low cloze (LC probability while functional magnetic resonance imaging was conducted. Significant age-related reduction of cloze effect (LC vs. HC was found in several regions, especially the left middle frontal gyrus (MFG and right inferior frontal gyrus (IFG, which play an important role in semantic integration. Moreover, when accounting for global gray matter volume reduction, the age-cloze correlation in the left MFG and right IFG was absent. The results suggest that brain structural atrophy may disrupt brain response in aging brains, which then show less brain engagement in semantic integration.

  4. Recorded earthquake responses from the integrated seismic monitoring network of the Atwood Building, Anchorage, Alaska

    Science.gov (United States)

    Celebi, M.

    2006-01-01

    An integrated seismic monitoring system with a total of 53 channels of accelerometers is now operating in and at the nearby free-field site of the 20-story steel-framed Atwood Building in highly seismic Anchorage, Alaska. The building has a single-story basement and a reinforced concrete foundation without piles. The monitoring system comprises a 32-channel structural array and a 21-channel site array. Accelerometers are deployed on 10 levels of the building to assess translational, torsional, and rocking motions, interstory drift (displacement) between selected pairs of adjacent floors, and average drift between floors. The site array, located approximately a city block from the building, comprises seven triaxial accelerometers, one at the surface and six in boreholes ranging in depths from 15 to 200 feet (???5-60 meters). The arrays have already recorded low-amplitude shaking responses of the building and the site caused by numerous earthquakes at distances ranging from tens to a couple of hundred kilometers. Data from an earthquake that occurred 186 km away traces the propagation of waves from the deepest borehole to the roof of the building in approximately 0.5 seconds. Fundamental structural frequencies [0.58 Hz (NS) and 0.47 Hz (EW)], low damping percentages (2-4%), mode coupling, and beating effects are identified. The fundamental site frequency at approximately 1.5 Hz is close to the second modal frequencies (1.83 Hz NS and 1.43 EW) of the building, which may cause resonance of the building. Additional earthquakes prove repeatability of these characteristics; however, stronger shaking may alter these conclusions. ?? 2006, Earthquake Engineering Research Institute.

  5. Obesity challenges the hepatoprotective function of the integrated stress response to asparaginase exposure in mice.

    Science.gov (United States)

    Nikonorova, Inna A; Al-Baghdadi, Rana J T; Mirek, Emily T; Wang, Yongping; Goudie, Michael P; Wetstein, Berish B; Dixon, Joseph L; Hine, Christopher; Mitchell, James R; Adams, Christopher M; Wek, Ronald C; Anthony, Tracy G

    2017-04-21

    Obesity increases risk for liver toxicity by the anti-leukemic agent asparaginase, but the mechanism is unknown. Asparaginase activates the integrated stress response (ISR) via sensing amino acid depletion by the eukaryotic initiation factor 2 (eIF2) kinase GCN2. The goal of this work was to discern the impact of obesity, alone versus alongside genetic disruption of the ISR, on mechanisms of liver protection during chronic asparaginase exposure in mice. Following diet-induced obesity, biochemical analysis of livers revealed that asparaginase provoked hepatic steatosis that coincided with activation of another eIF2 kinase PKR-like endoplasmic reticulum kinase (PERK), a major ISR transducer to ER stress. Genetic loss of Gcn2 intensified hepatic PERK activation to asparaginase, yet surprisingly, mRNA levels of key ISR gene targets such as Atf5 and Trib3 failed to increase. Instead, mechanistic target of rapamycin complex 1 (mTORC1) signal transduction was unleashed, and this coincided with liver dysfunction reflected by a failure to maintain hydrogen sulfide production or apolipoprotein B100 (ApoB100) expression. In contrast, obese mice lacking hepatic activating transcription factor 4 ( Atf4 ) showed an exaggerated ISR and greater loss of endogenous hydrogen sulfide but normal inhibition of mTORC1 and maintenance of ApoB100 during asparaginase exposure. In both genetic mouse models, expression and phosphorylation of Sestrin2, an ATF4 gene target, was increased by asparaginase, suggesting mTORC1 inhibition during asparaginase exposure is not driven via eIF2-ATF4-Sestrin2. In conclusion, obesity promotes a maladaptive ISR during asparaginase exposure. GCN2 functions to repress mTORC1 activity and maintain ApoB100 protein levels independently of Atf4 expression, whereas hydrogen sulfide production is promoted via GCN2-ATF4 pathway. © 2017 by The American Society for Biochemistry and Molecular Biology, Inc.

  6. Thyroid hormone regulation of Sirtuin 1 expression and implications to integrated responses in fasted mice.

    Science.gov (United States)

    Cordeiro, Aline; de Souza, Luana Lopes; Oliveira, Lorraine Soares; Faustino, Larissa Costa; Santiago, Letícia Aragão; Bloise, Flavia Fonseca; Ortiga-Carvalho, Tania Maria; Almeida, Norma Aparecida Dos Santos; Pazos-Moura, Carmen Cabanelas

    2013-02-01

    Sirtuin 1 (SIRT1), a NAD(+)-dependent deacetylase, has been connected to beneficial effects elicited by calorie restriction. Physiological adaptation to starvation requires higher activity of SIRT1 and also the suppression of thyroid hormone (TH) action to achieve energy conservation. Here, we tested the hypothesis that those two events are correlated and that TH may be a regulator of SIRT1 expression. Forty-eight-hour fasting mice exhibited reduced serum TH and increased SIRT1 protein content in liver and brown adipose tissue (BAT), and physiological thyroxine replacement prevented or attenuated the increment of SIRT1 in liver and BAT of fasted mice. Hypothyroid mice exhibited increased liver SIRT1 protein, while hyperthyroid ones showed decreased SIRT1 in liver and BAT. In the liver, decreased protein is accompanied by reduced SIRT1 activity and no alteration in its mRNA. Hyperthyroid and hypothyroid mice exhibited increases and decreases in food intake and body weight gain respectively. Food-restricted hyperthyroid animals (pair-fed to euthyroid group) exhibited liver and BAT SIRT1 protein levels intermediary between euthyroid and hyperthyroid mice fed ad libitum. Mice with TH resistance at the liver presented increased hepatic SIRT1 protein and activity, with no alteration in Sirt1 mRNA. These results suggest that TH decreases SIRT1 protein, directly and indirectly, via food ingestion control and, in the liver, this reduction involves TRβ. The SIRT1 reduction induced by TH has important implication to integrated metabolic responses to fasting, as the increase in SIRT1 protein requires the fasting-associated suppression of TH serum levels.

  7. Sensorimotor integration in chronic stroke: Baseline differences and response to sensory training.

    Science.gov (United States)

    Brown, Katlyn E; Neva, Jason L; Feldman, Samantha J; Staines, W Richard; Boyd, Lara A

    2018-01-01

    The integration of somatosensory information from the environment into the motor cortex to inform movement is essential for motor function. As motor deficits commonly persist into the chronic phase of stroke recovery, it is important to understand potential contributing factors to these deficits, as well as their relationship with motor function. To date the impact of chronic stroke on sensorimotor integration has not been thoroughly investigated. The current study aimed to comprehensively examine the influence of chronic stroke on sensorimotor integration, and determine whether sensorimotor integration can be modified with an intervention. Further, it determined the relationship between neurophysiological measures of sensorimotor integration and motor deficits post-stroke. Fourteen individuals with chronic stroke and twelve older healthy controls participated. Motor impairment and function were quantified in individuals with chronic stroke. Baseline neurophysiology was assessed using nerve-based measures (short- and long-latency afferent inhibition, afferent facilitation) and vibration-based measures of sensorimotor integration, which paired vibration with single and paired-pulse TMS techniques. Neurophysiological assessment was performed before and after a vibration-based sensory training paradigm to assess changes within these circuits. Vibration-based, but not nerve-based measures of sensorimotor integration were different in individuals with chronic stroke, as compared to older healthy controls, suggesting that stroke differentially impacts integration of specific types of somatosensory information. Sensorimotor integration was behaviourally relevant in that it related to both motor function and impairment post-stroke. Finally, sensory training modulated sensorimotor integration in individuals with chronic stroke and controls. Sensorimotor integration is differentially impacted by chronic stroke based on the type of afferent feedback. However, both nerve

  8. Integration of anatomical and external response mappings explains crossing effects in tactile localization: A probabilistic modeling approach.

    Science.gov (United States)

    Badde, Stephanie; Heed, Tobias; Röder, Brigitte

    2016-04-01

    To act upon a tactile stimulus its original skin-based, anatomical spatial code has to be transformed into an external, posture-dependent reference frame, a process known as tactile remapping. When the limbs are crossed, anatomical and external location codes are in conflict, leading to a decline in tactile localization accuracy. It is unknown whether this impairment originates from the integration of the resulting external localization response with the original, anatomical one or from a failure of tactile remapping in crossed postures. We fitted probabilistic models based on these diverging accounts to the data from three tactile localization experiments. Hand crossing disturbed tactile left-right location choices in all experiments. Furthermore, the size of these crossing effects was modulated by stimulus configuration and task instructions. The best model accounted for these results by integration of the external response mapping with the original, anatomical one, while applying identical integration weights for uncrossed and crossed postures. Thus, the model explained the data without assuming failures of remapping. Moreover, performance differences across tasks were accounted for by non-individual parameter adjustments, indicating that individual participants' task adaptation results from one common functional mechanism. These results suggest that remapping is an automatic and accurate process, and that the observed localization impairments in touch result from a cognitively controlled integration process that combines anatomically and externally coded responses.

  9. HVAC systems and equipment

    Energy Technology Data Exchange (ETDEWEB)

    Taylor, S.T. (Linford Air and Refrigeration Company, Oakland, CA (US))

    1990-02-01

    The author discusses the section of the ASHRAE Standard 90.1-1989 which addresses HVAC systems and equipment. New features of HVAC systems mandatory general requirements are described. New prescriptive requirements are detailed.

  10. Personal Protective Equipment

    National Research Council Canada - National Science Library

    1998-01-01

    ... of personal protective equipment A safety program for new employees is a necessary part of any orientation program An on-going safety program should be used to motivate employees to continue to use...

  11. Equipment for hydraulic testing

    International Nuclear Information System (INIS)

    Jacobsson, L.; Norlander, H.

    1981-07-01

    Hydraulic testing in boreholes is one major task of the hydrogeological program in the Stripa Project. A new testing equipment for this purpose was constructed. It consists of a downhole part and a surface part. The downhole part consists of two packers enclosing two test-sections when inflated; one between the packers and one between the bottom packer and the bottom of the borehole. A probe for downhole electronics is also included in the downhole equipment together with electrical cable and nylon tubing. In order to perform shut-in and pulse tests with high accuracy a surface controlled downhole valve was constructed. The surface equipment consists of the data acquisition system, transducer amplifier and surface gauges. In the report detailed descriptions of each component in the whole testing equipment are given. (Auth.)

  12. Requirements for industrial x-ray equipment

    International Nuclear Information System (INIS)

    1987-01-01

    This safety code is concerned with the protection of all individuals who may be exposed to radiation emitted by X-ray equipment operating at energies up to 1 MeV as used in industrial radiography. This code presents basic radiation safety information for the protection of personnel operating and servicing X-ray equipment and other workers and the general public in the vicinity of areas where X-ray equipment is in operation. It specifies general safety features of design, construction and functioning of X-ray equipment and facilities; describes the responsibilities of the user, operator and maintenance personnel; contains recommendations to ensure that the X-ray equipment is used and maintained in accordance with the ALARA principle; and describes a program of personnel monitoring and radiation safety surveys. ( 6 refs., 5 tabs., 4 figs.)

  13. Electronic quality control on dental x-rays equipment

    International Nuclear Information System (INIS)

    Pomares C, Martin

    1996-09-01

    A brief description of dental x-ray equipment is done. The non-invasive quality control is treated as than the responsibilities from the dentists to the patient and the equipment. A propose for quality control for dental x-ray equipment, film and developer is include

  14. Equipment Reliability Program in NPP Krsko

    International Nuclear Information System (INIS)

    Skaler, F.; Djetelic, N.

    2006-01-01

    Operation that is safe, reliable, effective and acceptable to public is the common message in a mission statement of commercial nuclear power plants (NPPs). To fulfill these goals, nuclear industry, among other areas, has to focus on: 1 Human Performance (HU) and 2 Equipment Reliability (EQ). The performance objective of HU is as follows: The behaviors of all personnel result in safe and reliable station operation. While unwanted human behaviors in operations mostly result directly in the event, the behavior flaws either in the area of maintenance or engineering usually cause decreased equipment reliability. Unsatisfied Human performance leads even the best designed power plants into significant operating events, which can be found as well-known examples in nuclear industry. Equipment reliability is today recognized as the key to success. While the human performance at most NPPs has been improving since the start of WANO / INPO / IAEA evaluations, the open energy market has forced the nuclear plants to reduce production costs and operate more reliably and effectively. The balance between these two (opposite) goals has made equipment reliability even more important for safe, reliable and efficient production. Insisting on on-line operation by ignoring some principles of safety could nowadays in a well-developed safety culture and human performance environment exceed the cost of electricity losses. In last decade the leading USA nuclear companies put a lot of effort to improve equipment reliability primarily based on INPO Equipment Reliability Program AP-913 at their NPP stations. The Equipment Reliability Program is the key program not only for safe and reliable operation, but also for the Life Cycle Management and Aging Management on the way to the nuclear power plant life extension. The purpose of Equipment Reliability process is to identify, organize, integrate and coordinate equipment reliability activities (preventive and predictive maintenance, maintenance

  15. An integrated health sector response to violence against women in Malaysia: lessons for supporting scale up

    Directory of Open Access Journals (Sweden)

    Colombini Manuela

    2012-07-01

    Full Text Available Abstract Background Malaysia has been at the forefront of the development and scale up of One-Stop Crisis Centres (OSCC - an integrated health sector model that provides comprehensive care to women and children experiencing physical, emotional and sexual abuse. This study explored the strengths and challenges faced during the scaling up of the OSCC model to two States in Malaysia in order to identify lessons for supporting successful scale-up. Methods In-depth interviews were conducted with health care providers, policy makers and key informants in 7 hospital facilities. This was complemented by a document analysis of hospital records and protocols. Data were coded and analysed using NVivo 7. Results The implementation of the OSCC model differed between hospital settings, with practise being influenced by organisational systems and constraints. Health providers generally tried to offer care to abused women, but they are not fully supported within their facility due to lack of training, time constraints, limited allocated budget, or lack of referral system to external support services. Non-specialised hospitals in both States struggled with a scarcity of specialised staff and limited referral options for abused women. Despite these challenges, even in more resource-constrained settings staff who took the initiative found it was possible to adapt to provide some level of OSCC services, such as referring women to local NGOs or community support groups, or training nurses to offer basic counselling. Conclusions The national implementation of OSCC provides a potentially important source of support for women experiencing violence. Our findings confirm that pilot interventions for health sector responses to gender based violence can be scaled up only when there is a sound health infrastructure in place – in other words a supportive health system. Furthermore, the successful replication of the OSCC model in other similar settings requires that the

  16. Report on the emergency response training and equipment activities through fiscal year 1992 for the transportation of transuranic waste to the Waste Isolation Pilot Plant

    International Nuclear Information System (INIS)

    1992-11-01

    The Waste Isolation Pilot Plant (WIPP) is a research and development facility with the mission of demonstrating the safe shipment, emplacement, and retrieval of radioactive transuranic (TRU) wastes resulting from the defense activities and programs of the United States. It is the only long-term storage facility constructed for TRU waste. This report provides the status on the Department of Energy (DOE) efforts as of September 30, 1992, regarding emergency response training provided to local, state, and tribal governments for waste shipments to the WIPP, as required by section 16(c)(1)(A) of the Waste Isolation Pilot Plant Land Withdrawal Act (Public Law 102-579). This is an update to the April 1992 report (DOE/WIPP 92003) which provided status through 1991. This report will be updated and issued annually. Because of a growing public awareness of transportation-activities involving nuclear materials, this report was prepared to provide a status of the DOE's activities in this regard, as well as the cooperative efforts between the DOE and state and tribal governments

  17. Systems integration: an effective and innovative response to emerging biological threats.

    Science.gov (United States)

    House, Robert V

    2007-04-20

    A rapid and effective development of vaccines and other prophylactics, as well as novel therapeutics, against emerging threats requires the development and implementation of novel strategies. One such strategy is the integrator approach. This approach utilizes an integrated development team comprising expertise in program management, scientific management, clinical research, preclinical/nonclinical development, manufacturing, testing, risk management, quality assurance, and regulatory strategy and compliance. Key to the success of this approach is the successful management of subcontracted work, as well as the seamless integration of multiple systems and data inputs into a coherent development plan.

  18. Integrating Social Responsibility into Business School Undergraduate Education: A Student Perspective

    Science.gov (United States)

    Barber, Nelson A.; Venkatachalam, Venky

    2013-01-01

    Organizations and society at large recognize that ethically and socially responsible behavior plays a crucial role in good business practices. Debate about social responsibility centers on the responsibilities of consumers and businesses working towards a sustainable future with a new focus on business education. This realization has led employers…

  19. Integrating plant ecological responses to climate extremes from individual to ecosystem levels.

    Science.gov (United States)

    Felton, Andrew J; Smith, Melinda D

    2017-06-19

    Climate extremes will elicit responses from the individual to the ecosystem level. However, only recently have ecologists begun to synthetically assess responses to climate extremes across multiple levels of ecological organization. We review the literature to examine how plant responses vary and interact across levels of organization, focusing on how individual, population and community responses may inform ecosystem-level responses in herbaceous and forest plant communities. We report a high degree of variability at the individual level, and a consequential inconsistency in the translation of individual or population responses to directional changes in community- or ecosystem-level processes. The scaling of individual or population responses to community or ecosystem responses is often predicated upon the functional identity of the species in the community, in particular, the dominant species. Furthermore, the reported stability in plant community composition and functioning with respect to extremes is often driven by processes that operate at the community level, such as species niche partitioning and compensatory responses during or after the event. Future research efforts would benefit from assessing ecological responses across multiple levels of organization, as this will provide both a holistic and mechanistic understanding of ecosystem responses to increasing climatic variability.This article is part of the themed issue 'Behavioural, ecological and evolutionary responses to extreme climatic events'. © 2017 The Author(s).

  20. From microgravity to osmotic conditions: mechanical integration of plant cells in response to stress

    Science.gov (United States)

    Wojtaszek, Przemyslaw; Kasprowicz, Anna; Michalak, Michal; Janczara, Renata; Volkmann, Dieter; Baluska, Frantisek

    Chemical reactions and interactions between molecules are commonly thought of as being at the basis of Life. Research of recent years, however, is more and more evidently indicating that physical forces are profoundly affecting the functioning of life at all levels of its organiza-tion. To detect and to respond to such forces, plant cells need to be integrated mechanically. Cell walls are the outermost functional zone of plant cells. They surround the individual cells, and also form a part of the apoplast. In cell suspensions, cell walls are embedded in the cul-ture medium which can be considered as a superapoplast. Through physical and chemical interactions they provide a basis for the structural and functional cell wall-plasma membrane-cytoskeleton (WMC) continuum spanning the whole cell. Here, the working of WMC contin-uum, and the participation of signalling molecules, like NO, would be presented in the context of plant responses to stress. In addition, the effects of the changing composition of WMC continuum will be considered, with particular attention paid to the modifications of the WMC components. Plant cells are normally adapted to changing osmotic conditions, resulting from variable wa-ter availability. The appearance of the osmotic stress activates adaptory mechanisms. If the strength of osmotic stress grows relatively slowly over longer period of time, the cells are able to adapt to conditions that are lethal to non-adapted cells. During stepwise adaptation of tobacco BY-2 suspension cells to the presence of various osmotically active agents, cells diverged into independent, osmoticum type-specific lines. In response to ionic agents (NaCl, KCl), the adhe-sive properties were increased and randomly dividing cells formed clumps, while cells adapted to nonionic osmotica (mannitol, sorbitol, PEG) revealed ordered pattern of precisely positioned cell divisions, resulting in the formation of long cell files. Changes in the growth patterns were accompanied by

  1. Maintenance and fabrication of nuclear electronic equipment

    International Nuclear Information System (INIS)

    Hong, Seok Boong; Chung, Chong Eun; Hwang, In Koo; Koo, In Soo; Park, Bum; Kim, Soo Hee; Lee, Seong Joo; Kim, Min Seok; Choi, Wha Lim

    2011-12-01

    - process equipment at PIEF, Chemical Analysis Team and RWFTF have been calibrated. - The electronic equipment and radiation equipment at RWTF and PIEF have been prepared. - Development and installation of integrated RMS software for Hanaro Cold Neutron Laboratory Building(CNLB) RMS, and development and performance upgrade of a portal monitor for CNLB. - Performance test of the Hardware/Software of digital unit controller has been performed, and functional upgrade of the Hardware/Software of stimulator for SMART MMIS performance test facility has also been performed. - A controller of high voltage power supply for a small electron beam generator and a controller for razer pinning and a remote monitoring apparatus of cathode power supply for a 0.2 Mev. small electron beam generator have been designed and fabricated. - Database construction for effective maintenance for the process equipment and radiation instruments are designed and constructed

  2. Thermal response of integral abutment bridges with mechanically stabilized earth walls.

    Science.gov (United States)

    2013-03-01

    The advantages of integral abutment bridges (IABs) include reduced maintenance costs and increased useful life spans. : However, improved procedures are necessary to account for the impacts of cyclic thermal displacements on IAB components, : includi...

  3. OCCUPATIONAL HEALTH AND SAFETY INTEGRATION IN CORPORATE SOCIAL RESPONSIBILITY POLICIES WITHIN B.R.D. - G.S.G. ROMANIA

    Directory of Open Access Journals (Sweden)

    CODRUŢA DURA

    2014-10-01

    Full Text Available Corporate Social Responsibility can be an opportunity for integration and approach of issues related to Occupational Health and Safety, seen from a broader perspective than that of mere correlation with legislation. The present paper aims at analysing the way the growing interest, in terms of Corporate Social Responsibility, can contribute to improving the implementation of appropriate systems to prevent accidents at work within Romanian organisations. The case study that illustrates the good practices of BRD-Groupe Société Générale revealed the role of the instruments analysed as catalysts for improving the activity of occupational safety and health.

  4. Diagnostic x-ray equipment and its use

    International Nuclear Information System (INIS)

    1993-01-01

    The guide contains the requirements for the use, structure and operation of diagnostic x-ray equipment necessary to ensure the radiation safety of workers and patients. The guide is intended for the party responsible for operating the x-ray units, the staff operating, installing and maintaining x-ray examination equipment, and companies manufacturing and selling such equipment. Special requirements for mammographic and dental x-ray equipments are given in separate ST guides. (5 refs., 1 figs., 2 tabs.)

  5. Equipment abnormality monitoring device

    International Nuclear Information System (INIS)

    Ando, Yasumasa

    1991-01-01

    When an operator hears sounds in a plantsite, the operator compares normal sounds of equipment which he previously heard and remembered with sounds he actually hears, to judge if they are normal or abnormal. According to the method, there is a worry that abnormal conditions can not be appropriately judged in a case where the number of objective equipments is increased and in a case that the sounds are changed gradually slightly. Then, the device of the present invention comprises a plurality of monitors for monitoring the operation sound of equipments, a recording/reproducing device for recording and reproducing the signals, a selection device for selecting the reproducing signals among the recorded signals, an acoustic device for converting the signals to sounds, a switching device for switching the signals to be transmitted to the acoustic device between to signals of the monitor and the recording/reproducing signals. The abnormality of the equipments can be determined easily by comparing the sounds representing the operation conditions of equipments for controlling the plant operation and the sounds recorded in their normal conditions. (N.H.)

  6. Prioritizing equipment for replacement.

    Science.gov (United States)

    Capuano, Mike

    2010-01-01

    It is suggested that clinical engineers take the lead in formulating evaluation processes to recommend equipment replacement. Their skill, knowledge, and experience, combined with access to equipment databases, make them a logical choice. Based on ideas from Fennigkoh's scheme, elements such as age, vendor support, accumulated maintenance cost, and function/risk were used.6 Other more subjective criteria such as cost benefits and efficacy of newer technology were not used. The element of downtime was also omitted due to the data element not being available. The resulting Periop Master Equipment List and its rationale was presented to the Perioperative Services Program Council. They deemed the criteria to be robust and provided overwhelming acceptance of the list. It was quickly put to use to estimate required capital funding, justify items already thought to need replacement, and identify high-priority ranked items for replacement. Incorporating prioritization criteria into an existing equipment database would be ideal. Some commercially available systems do have the basic elements of this. Maintaining replacement data can be labor-intensive regardless of the method used. There is usually little time to perform the tasks necessary for prioritizing equipment. However, where appropriate, a clinical engineering department might be able to conduct such an exercise as shown in the following case study.

  7. The influence of personal protection equipment, occupant body size, and restraint system on the frontal impact responses of Hybrid III ATDs in tactical vehicles.

    Science.gov (United States)

    Zaseck, Lauren Wood; Orton, Nichole Ritchie; Gruber, Rebekah; Rupp, Jonathan; Scherer, Risa; Reed, Matthew; Hu, Jingwen

    2017-08-18

    TAP. ATD kinematics and injury outcomes were determined for each test. Maximum excursions were generally greater in the 95th percentile male compared to the 50th percentile male ATD and in ATDs wearing TAP compared to ATDs without TAP. Pretensioners and load limiters were effective in decreasing excursions and injury measures, even when the ATD was outfitted in military gear. ATD injury response and kinematics are influenced by the size of the ATD, military gear, and restraint system. This study has provided important data for validating FE models of military occupants, which can be used for design optimization of military vehicle restraint systems.

  8. Similarity principles for equipment qualification by experience

    International Nuclear Information System (INIS)

    Kana, D.D.; Pomerening, D.J.

    1988-07-01

    A methodology is developed for seismic qualification of nuclear plant equipment by applying similarity principles to existing experience data. Experience data are available from previous qualifications by analysis or testing, or from actual earthquake events. Similarity principles are defined in terms of excitation, equipment physical characteristics, and equipment response. Physical similarity is further defined in terms of a critical transfer function for response at a location on a primary structure, whose response can be assumed directly related to ultimate fragility of the item under elevated levels of excitation. Procedures are developed for combining experience data into composite specifications for qualification of equipment that can be shown to be physically similar to the reference equipment. Other procedures are developed for extending qualifications beyond the original specifications under certain conditions. Some examples for application of the procedures and verification of them are given for certain cases that can be approximated by a two degree of freedom simple primary/secondary system. Other examples are based on use of actual test data available from previous qualifications. Relationships of the developments with other previously-published methods are discussed. The developments are intended to elaborate on the rather broad revised guidelines developed by the IEEE 344 Standards Committee for equipment qualification in new nuclear plants. However, the results also contribute to filling a gap that exists between the IEEE 344 methodology and that previously developed by the Seismic Qualification Utilities Group. The relationship of the results to safety margin methodology is also discussed. (author)

  9. The integrated disease surveillance and response system in northern Ghana: challenges to the core and support functions

    OpenAIRE

    Adokiya, Martin Nyaaba; Awoonor-Williams, John K.; Beiersmann, Claudia; Müller, Olaf

    2015-01-01

    Background: The integrated disease surveillance and response (IDSR) strategy was adopted in Ghana over a decade ago, yet gaps still remain in its proper functioning. The objective of this study was to assess the core and support functions of the IDSR system at the periphery level of the health system in northern Ghana. Methods: A qualitative study has been conducted among 18 key informants in two districts of Upper East Region. The respondents were from 9 health facilities considered repres...

  10. Graph-based semi-supervised learning with genomic data integration using condition-responsive genes applied to phenotype classification.

    Science.gov (United States)

    Doostparast Torshizi, Abolfazl; Petzold, Linda R

    2018-01-01

    Data integration methods that combine data from different molecular levels such as genome, epigenome, transcriptome, etc., have received a great deal of interest in the past few years. It has been demonstrated that the synergistic effects of different biological data types can boost learning capabilities and lead to a better understanding of the underlying interactions among molecular levels. In this paper we present a graph-based semi-supervised classification algorithm that incorporates latent biological knowledge in the form of biological pathways with gene expression and DNA methylation data. The process of graph construction from biological pathways is based on detecting condition-responsive genes, where 3 sets of genes are finally extracted: all condition responsive genes, high-frequency condition-responsive genes, and P-value-filtered genes. The proposed approach is applied to ovarian cancer data downloaded from the Human Genome Atlas. Extensive numerical experiments demonstrate superior performance of the proposed approach compared to other state-of-the-art algorithms, including the latest graph-based classification techniques. Simulation results demonstrate that integrating various data types enhances classification performance and leads to a better understanding of interrelations between diverse omics data types. The proposed approach outperforms many of the state-of-the-art data integration algorithms. © The Author 2017. Published by Oxford University Press on behalf of the American Medical Informatics Association. All rights reserved. For Permissions, please email: journals.permissions@oup.com

  11. Radioactive decontamination of equipment

    International Nuclear Information System (INIS)

    1982-03-01

    After a recall of some definitions relating to decontamination techniques and of the regulation into effect, the principles to be respected to arrange rationally work zones are quoted while insisting more particularly on the types of coatings which facilitate maintenance operations and the dismantling of these installations. Then, the processes and equipments to use in decontamination units for routine or particular operations are described; the list of recommended chemical products to decontaminate the equipment is given. The influence of these treatments on the state and the duration of life of equipments is studied, and some perfectible methods are quoted. In the appendix, are given: the limits of surface contamination accepted in the centers; a standard project which defines the criteria of admissible residual contamination in wastes considered as cold wastes; some remarks on the interest that certain special ventilation and air curtain devices for the protection of operators working on apparatus generating contaminated dusts [fr

  12. Seismic qualification of non-safety class equipment whose failure would damage safety class equipment

    International Nuclear Information System (INIS)

    LaSalle, F.R.

    1991-01-01

    Both Code of Federal Regulations, Title 10, Part 50, and US Department of Energy Order 6340.1A have requirements to assess the interaction of non-safety and safety class structures and equipment during a seismic event to maintain the safety function. At the Hanford Site, a cost effective program has been developed to perform the evaluation of non-safety class equipment. Seismic qualification is performed by analysis, test, or upgrading of the equipment to ensure the integrity of safety class structures and equipment. This paper gives a brief overview and synopsis that address design analysis guidelines including applied loading, damping values, component anchorage, allowable loads, and stresses. Test qualification of equipment and walkdown acceptance criteria for heating ampersand ventilation (H ampersand V) ducting, conduit, cable tray, missile zone of influence, as well as energy criteria are presented

  13. Equipment Operational Requirements

    Energy Technology Data Exchange (ETDEWEB)

    Greenwalt, B; Henderer, B; Hibbard, W; Mercer, M

    2009-06-11

    The Iraq Department of Border Enforcement is rich in personnel, but poor in equipment. An effective border control system must include detection, discrimination, decision, tracking and interdiction, capture, identification, and disposition. An equipment solution that addresses only a part of this will not succeed, likewise equipment by itself is not the answer without considering the personnel and how they would employ the equipment. The solution should take advantage of the existing in-place system and address all of the critical functions. The solutions are envisioned as being implemented in a phased manner, where Solution 1 is followed by Solution 2 and eventually by Solution 3. This allows adequate time for training and gaining operational experience for successively more complex equipment. Detailed descriptions of the components follow the solution descriptions. Solution 1 - This solution is based on changes to CONOPs, and does not have a technology component. It consists of observers at the forts and annexes, forward patrols along the swamp edge, in depth patrols approximately 10 kilometers inland from the swamp, and checkpoints on major roads. Solution 2 - This solution adds a ground sensor array to the Solution 1 system. Solution 3 - This solution is based around installing a radar/video camera system on each fort. It employs the CONOPS from Solution 1, but uses minimal ground sensors deployed only in areas with poor radar/video camera coverage (such as canals and streams shielded by vegetation), or by roads covered by radar but outside the range of the radar associated cameras. This document provides broad operational requirements for major equipment components along with sufficient operational details to allow the technical community to identify potential hardware candidates. Continuing analysis will develop quantities required and more detailed tactics, techniques, and procedures.

  14. Charging equipment. Ladegeraet

    Energy Technology Data Exchange (ETDEWEB)

    Neumann, E

    1981-09-17

    The invention refers to a charging equipment, particularly on board charging equipment for charging traction batteries of an electric vehicle from the AC mains supply, consisting of a DC converter, which contains a controlled power transistor, a switching off unloading circuit and a power transmitter, where the secondary winding is connected in series with a rectifier diode, and a smoothing capacitor is connected in parallel with this series circuit. A converter module is provided, which consists of two DC voltage converters, whose power transistors are controlled by a control circuit in opposition with a phase displacement of 180/sup 0/.

  15. LEGAL ASPECTS OF CORPORATE SOCIAL RESPONSIBILITY IN UKRAINE ON THE WAY TO EUROPEAN INTEGRATION

    OpenAIRE

    Kolohoida, Oleksandra; Lukach, Iryna; Poiedynok, Valeriia

    2017-01-01

    Summary: Corporate social responsibility is a new form of dialogue between business, society and the state. This article explores the possibilities of legislating for corporate social responsibility in Ukraine in respect of implementing the Association Agreement of 2014 between the European Union and its Member States, of the one part, and Ukraine, of the other part. Different approaches to introducing corporate social responsibility standards are examined. The paper considers not only intern...

  16. Day-ahead stochastic economic dispatch of wind integrated power system considering demand response of residential hybrid energy system

    International Nuclear Information System (INIS)

    Jiang, Yibo; Xu, Jian; Sun, Yuanzhang; Wei, Congying; Wang, Jing; Ke, Deping; Li, Xiong; Yang, Jun; Peng, Xiaotao; Tang, Bowen

    2017-01-01

    Highlights: • Improving the utilization of wind power by the demand response of residential hybrid energy system. • An optimal scheduling of home energy management system integrating micro-CHP. • The scattered response capability of consumers is aggregated by demand bidding curve. • A stochastic day-ahead economic dispatch model considering demand response and wind power. - Abstract: As the installed capacity of wind power is growing, the stochastic variability of wind power leads to the mismatch of demand and generated power. Employing the regulating capability of demand to improve the utilization of wind power has become a new research direction. Meanwhile, the micro combined heat and power (micro-CHP) allows residential consumers to choose whether generating electricity by themselves or purchasing from the utility company, which forms a residential hybrid energy system. However, the impact of the demand response with hybrid energy system contained micro-CHP on the large-scale wind power utilization has not been analyzed quantitatively. This paper proposes an operation optimization model of the residential hybrid energy system based on price response, integrating micro-CHP and smart appliances intelligently. Moreover, a novel load aggregation method is adopted to centralize scattered response capability of residential load. At the power grid level, a day-ahead stochastic economic dispatch model considering demand response and wind power is constructed. Furthermore, simulation is conducted respectively on the modified 6-bus system and IEEE 118-bus system. The results show that with the method proposed, the wind power curtailment of the system decreases by 78% in 6-bus system. In the meantime, the energy costs of residential consumers and the operating costs of the power system reduced by 10.7% and 11.7% in 118-bus system, respectively.

  17. Integrating the Rights of the Child with the Responsibility of the Parent

    Science.gov (United States)

    Scholz, Carolyn L.

    2011-01-01

    This paper will explore the balance between children's rights and parental responsibility from a family systems perspective. Children do not grow up in a vacuum; they are part of a biological, psychological and social system. The interaction of the child and parent within this system must include the development of responsibilities by the parent…

  18. Integrating Public Relations and Legal Responses during a Crisis: The Case of Odwalla, Inc.

    Science.gov (United States)

    Martinelli, Kathleen A.; Briggs, William

    1998-01-01

    Examines the crisis-communication strategies employed by Odwalla, Inc. during its juice contamination crisis, a crisis whose impact on public health and safety gave it the potential for developing into an issue that required public policy relief. Finds that public-relations response strategies dominated legal response strategies, followed by mixed…

  19. Experimental equipment, ch. 6

    International Nuclear Information System (INIS)

    Boomstra, F.; Hoogenboom, A.M.; Prins, C.M.; Strasters, B.A.; Vermeer, A.; Wit, P. de; Zwol, N.A. van.

    1977-01-01

    The experimental equipment in use at Utrecht university is discussed. Attention is paid to the tandem Van de Graaff accelerator and the 4MV and 1MV accelerators. The detection systems for gamma-ray spectroscopy are reviewed with emphasis on the compton-suppression spectrometer. The data-handling system used for experiments with the tandem is also briefly discussed

  20. Equipment gift to Monaco

    International Nuclear Information System (INIS)

    1970-01-01

    Research work at the Agency's Laboratory of Marine Radioactivity in Monaco, including that concerned with pollution of the sea, has been made more effective by its latest acquisition of equipment. This is a spectrophotometer donated by the Federal Republic of Germany. (author)

  1. Lifetime of Mechanical Equipment

    Energy Technology Data Exchange (ETDEWEB)

    Leland, K.

    1999-07-01

    The gas plant at Kaarstoe was built as part of the Statpipe gas transport system and went on stream in 1985. In 1993 another line was routed from the Sleipner field to carry condensate, and the plant was extended accordingly. Today heavy additional supply- and export lines are under construction, and the plant is extended more than ever. The main role of the factory is to separate the raw gas into commercial products and to pump or ship it to the markets. The site covers a large number of well-known mechanical equipment. This presentation deals with piping, mechanical and structural disciplines. The lifetime of mechanical equipment is often difficult to predict as it depends on many factors, and the subject is complex. Mechanical equipment has been kept in-house, which provides detailed knowledge of the stages from a new to a 14 years old plant. The production regularity has always been very high, as required. The standard of the equipment is well kept, support systems are efficient, and human improvisation is extremely valuable.

  2. Safeguards techniques and equipment

    International Nuclear Information System (INIS)

    1997-01-01

    The current booklet is intended to give a full and balanced description of the techniques and equipment used for both nuclear material accountancy and containment and surveillance measures, and for the new safeguards measure of environmental sampling. As new verification measures continue to be developed, the material in the booklet will be periodically reviewed and updated versions issued. (author)

  3. Electrical equipment design library

    International Nuclear Information System (INIS)

    1994-01-01

    This book guides the design supervision, construction order for electrical equipment. The contents of this library are let's use electricity like this, leading-in-pole and casual power, electric pole install below 300KVA, electric pole install below 301∼1000KVA, electric pole install exceed 1000KVA, rooftop install exceed 1000KVA, CUBICLE type, 154KV services. It adds an appendix.

  4. Orphee reactor experimental equipment

    International Nuclear Information System (INIS)

    1987-01-01

    Experimental equipment around the ORPHEE reactor is presented. The neutron source; and the spectrometers and sample environment (inelastic and quasi-elastic scattering, elastic scattering, spread scattering, small angle scattering) are described. An experiment proposal and reports guide is supplied [fr

  5. Seismic qualification of equipment

    International Nuclear Information System (INIS)

    Heidebrecht, A.C.; Tso, W.K.

    1983-03-01

    This report describes the results of an investigation into the seismic qualification of equipment located in CANDU nuclear power plants. It is particularly concerned with the evaluation of current seismic qualification requirements, the development of a suitable methodology for the seismic qualification of safety systems, and the evaluation of seismic qualification analysis and testing procedures

  6. Underground coal equipment

    Energy Technology Data Exchange (ETDEWEB)

    Chadwick, J.

    2002-12-01

    This paper reports on increasing automation and enhanced productivity on longwalls, new development cutting and bolting technologies and haulage systems. Amongst equipment discussed is DBT's Electra series EL3000 shearer, the Dosco LH1400 roadheader with onboard bolters, and Joy 12 CM30 continuous miners. 4 photos.

  7. Use of an integrated containment and ultimate heat sink (UHS) response approach to evaluate nuclear power plant modifications

    International Nuclear Information System (INIS)

    Wetzel, M.C.; Vieira, A.T.; Patton, D.C.

    1994-01-01

    Detailed containment and Ultimate Heat Sink (UHS) performance evaluations often are required to support major plant modifications, such as power up-rates and steam generator replacements. These UHS and containment pressure and temperature response evaluations are interrelated. Not only is the containment heat load to the UHS a factor in these evaluations, but other heat loads, such as those from the spent fuel pool, may change as a result of the plant modification and impact containment or UHS response. Our experience is that if an integrated containment/UHS response model is developed prior to the feasibility evaluations for such plant modifications, significant savings in engineering hours can be achieved. This paper presents an overview of such a front-end engineering tool that has been developed and used to support engineering evaluations. 3 refs., 2 figs

  8. Paved with good intentions: global financial integration and the eurozone’s response

    NARCIS (Netherlands)

    Underhill, G.R.D.

    2011-01-01

    Regional governance systems may resolve the dilemmas of global financial integration, and the Eurozone is the most advanced attempt to do so. The Euroland sovereign debt crisis is a test of this proposition but the outcome finds the EU wanting. The first section places EMU in the broader context of

  9. Analysis of thermal-plastic response of shells of revolution by numerical integration

    International Nuclear Information System (INIS)

    Leonard, J.W.

    1975-01-01

    An economic technique for the numerical analysis of the elasto-plastic behaviour of shells of revolution would be of considerable value in the nuclear reactor industry. A numerical method based on the numerical integration of the governing shell equations has been shown, for elastic cases, to be more efficient than the finite element method when applied to shells of revolution. In the numerical integration method, the governing differential equations of motion are converted into a set of initial-value problems. Each initial-value problem is integrated numerically between meridional boundary points and recombined so as to satisfy boundary conditions. For large-deflection elasto-plastic behaviour, the equations are nonlinear and, hence, are recombined in an iterative manner using the Newton-Raphson procedure. Suppression techniques are incorporated in order to eliminate extraneous solutions within the numerical integration procedure. The Reissner-Meissner shell theory for shells of revolution is adopted to account for large deflection and higher-order rotation effects. The computer modelling of the equations is quite general in that specific shell segment geometries, e.g. cylindrical, spherical, toroidal, conical segments, and any combinations thereof can be handled easily. (Auth.)

  10. Transport fuel demand responses to fuel price and income projections : Comparison of integrated assessment models

    NARCIS (Netherlands)

    Edelenbosch, O. Y.; van Vuuren, Detlef; Bertram, C.; Carrara, S.; Emmerling, J.; Daly, H.; Kitous, A.; McCollum, D. L.; Saadi Failali, N.

    Income and fuel price pathways are key determinants in projections of the energy system in integrated assessment models. In recent years, more details have been added to the transport sector representation in these models. To better understand the model dynamics, this manuscript analyses transport

  11. Modelling of Hot Water Storage Tank for Electric Grid Integration and Demand Response Control

    DEFF Research Database (Denmark)

    Sinha, Rakesh; Bak-Jensen, Birgitte; Pillai, Jayakrishnan Radhakrishna

    2017-01-01

    District heating (DH), based on electric boilers, when integrated into electric network has potential of flexible load with direct/indirect storage to increase the dynamic stability of the grid in terms of power production and consumption with wind and solar. The two different models of electric...

  12. Analysis of thermal-plastic response of shells of revolution by numerical integration

    International Nuclear Information System (INIS)

    Leonard, J.W.

    1975-01-01

    A numerical method based instead on the numerical integration of the governing shell equations has been shown, for elastic cases, to be more efficient than the finite element method when applied to shells of revolution. In the numerical integration method, the governing differential equations of motions are converted into a set of initial-value problems. Each initial-value problem is integrated numerically between meridional boundary points and recombined so as to satisfy boundary conditions. For large-deflection elasto-plastic behavior, the equations are nonlinear and, hence, are recombined in an iterative manner using the Newton-Raphson procedure. Suppression techniques are incorporated in order to eliminate extraneous solutions within the numerical integration procedure. The Reissner-Meissner shell theory for shells of revolution is adopted to account for large deflection and higher-order rotation effects. The computer modelling of the equations is quite general in that specific shell segment geometries, e.g. cylindrical, spherical, toroidal, conical segments, and any combinations thereof can be handled easily. The elasto-plastic constitutive relations adopted are in accordance with currently recommended constitutive equations for inelastic design analysis of FFTF Components. The Von Mises yield criteria and associated flow rule is used and the kinematic hardening law is followed. Examples are considered in which stainless steels common to LMFBR application are used

  13. Progress on EPRI electrical equipment qualification research

    International Nuclear Information System (INIS)

    Sliter, G.E.

    1983-01-01

    The objective of EPRI's electrical equipment qualification research program is to provide technical assistance to utilities in meeting nuclear plant safety requirements in a manner consistent with the state of the art. This paper reports progress on several research projects including: radiation effects studies, which compile data on degradation of organic materials in electrical equipment exposed to operational and accident radiation doses; the Equipment Qualification Data Bank, which is a remotely accessible computer system for disseminating qualification information on in-plant equipment, seismic data, and materials data; an aging/seismic correlation program, which is providing test data showing that, in many cases, age degradation has a negligibly small effect on the performance of electrical components under seismic excitation; a review of condition monitoring techniques, which has identified surveillance methods for measuring key performance parameters that have the potential for predicting remaining equipment life; and large-scale hydrogen burn equipment response tests, which are providing data to assess the ability of equipment to remain functional during and after hydrogen burning in postulated degraded core accidents

  14. Study of the integrated immune response induced by an inactivated EV71 vaccine.

    Directory of Open Access Journals (Sweden)

    Longding Liu

    Full Text Available Enterovirus 71 (EV71, a major causative agent of hand-foot-and-mouth disease (HFMD, causes outbreaks among children in the Asia-Pacific region. A vaccine is urgently needed. Based on successful pre-clinical work, phase I and II clinical trials of an inactivated EV71 vaccine, which included the participants of 288 and 660 respectively, have been conducted. In the present study, the immune response and the correlated modulation of gene expression in the peripheral blood mononuclear cells (PBMCs of 30 infants (6 to 11 months immunized with this vaccine or placebo and consented to join this study in the phase II clinical trial were analyzed. The results showed significantly greater neutralizing antibody and specific T cell responses in vaccine group after two inoculations on days 0 and 28. Additionally, more than 600 functional genes that were up- or down-regulated in PBMCs were identified by the microarray assay, and these genes included 68 genes associated with the immune response in vaccine group. These results emphasize the gene expression profile of the immune system in response to an inactivated EV71 vaccine in humans and confirmed that such an immune response was generated as the result of the positive mobilization of the immune system. Furthermore, the immune response was not accompanied by the development of a remarkable inflammatory response.NCT01391494 and NCT01512706.

  15. A bi-level integrated generation-transmission planning model incorporating the impacts of demand response by operation simulation

    International Nuclear Information System (INIS)

    Zhang, Ning; Hu, Zhaoguang; Springer, Cecilia; Li, Yanning; Shen, Bo

    2016-01-01

    Highlights: • We put forward a novel bi-level integrated power system planning model. • Generation expansion planning and transmission expansion planning are combined. • The effects of two sorts of demand response in reducing peak load are considered. • Operation simulation is conducted to reflect the actual effects of demand response. • The interactions between the two levels can guarantee a reasonably optimal result. - Abstract: If all the resources in power supply side, transmission part, and power demand side are considered together, the optimal expansion scheme from the perspective of the whole system can be achieved. In this paper, generation expansion planning and transmission expansion planning are combined into one model. Moreover, the effects of demand response in reducing peak load are taken into account in the planning model, which can cut back the generation expansion capacity and transmission expansion capacity. Existing approaches to considering demand response for planning tend to overestimate the impacts of demand response on peak load reduction. These approaches usually focus on power reduction at the moment of peak load without considering the situations in which load demand at another moment may unexpectedly become the new peak load due to demand response. These situations are analyzed in this paper. Accordingly, a novel approach to incorporating demand response in a planning model is proposed. A modified unit commitment model with demand response is utilized. The planning model is thereby a bi-level model with interactions between generation-transmission expansion planning and operation simulation to reflect the actual effects of demand response and find the reasonably optimal planning result.

  16. Integrated response and transit time distributions of watersheds by combining hydrograph separation and long-term transit time modeling

    Directory of Open Access Journals (Sweden)

    M. C. Roa-García

    2010-08-01

    Full Text Available We present a new modeling approach analyzing and predicting the Transit Time Distribution (TTD and the Response Time Distribution (RTD from hourly to annual time scales as two distinct hydrological processes. The model integrates Isotope Hydrograph Separation (IHS and the Instantaneous Unit Hydrograph (IUH approach as a tool to provide a more realistic description of transit and response time of water in catchments. Individual event simulations and parameterizations were combined with long-term baseflow simulation and parameterizations; this provides a comprehensive picture of the catchment response for a long time span for the hydraulic and isotopic processes. The proposed method was tested in three Andean headwater catchments to compare the effects of land use on hydrological response and solute transport. Results show that the characteristics of events and antecedent conditions have a significant influence on TTD and RTD, but in general the RTD of the grassland dominated catchment is concentrated in the shorter time spans and has a higher cumulative TTD, while the forest dominated catchment has a relatively higher response distribution and lower cumulative TTD. The catchment where wetlands concentrate shows a flashier response, but wetlands also appear to prolong transit time.

  17. Demand Response Integration Through Agent-Based Coordination of Consumers in Virtual Power Plants

    DEFF Research Database (Denmark)

    Clausen, Anders; Umair, Aisha; Ma, Zheng

    2016-01-01

    of industrial loads. Coordination happens in response to Demand Response events, while considering local objectives in the industrial domain. We illustrate the applicability of our approach on a Virtual Power Plant scenario with three simulated greenhouses. The results suggest that the proposed design is able...... Power Plant design that is able to balance the demand of energy-intensive, industrial loads with the supply situation in the electricity grid. The proposed Virtual Power Plant design uses a novel inter-agent, multi-objective, multi-issue negotiation mechanism, to coordinate the electricity demands...... to coordinate the electricity demands of industrial loads, in compliance with external Demand Response events....

  18. A new approach for determining phase response curves reveals that Purkinje cells can act as perfect integrators.

    Directory of Open Access Journals (Sweden)

    Elena Phoka

    2010-04-01

    Full Text Available Cerebellar Purkinje cells display complex intrinsic dynamics. They fire spontaneously, exhibit bistability, and via mutual network interactions are involved in the generation of high frequency oscillations and travelling waves of activity. To probe the dynamical properties of Purkinje cells we measured their phase response curves (PRCs. PRCs quantify the change in spike phase caused by a stimulus as a function of its temporal position within the interspike interval, and are widely used to predict neuronal responses to more complex stimulus patterns. Significant variability in the interspike interval during spontaneous firing can lead to PRCs with a low signal-to-noise ratio, requiring averaging over thousands of trials. We show using electrophysiological experiments and simulations that the PRC calculated in the traditional way by sampling the interspike interval with brief current pulses is biased. We introduce a corrected approach for calculating PRCs which eliminates this bias. Using our new approach, we show that Purkinje cell PRCs change qualitatively depending on the firing frequency of the cell. At high firing rates, Purkinje cells exhibit single-peaked, or monophasic PRCs. Surprisingly, at low firing rates, Purkinje cell PRCs are largely independent of phase, resembling PRCs of ideal non-leaky integrate-and-fire neurons. These results indicate that Purkinje cells can act as perfect integrators at low firing rates, and that the integration mode of Purkinje cells depends on their firing rate.

  19. Integration of transcriptomic and metabolic data reveals hub transcription factors involved in drought stress response in sunflower (Helianthus annuus L.).

    Science.gov (United States)

    Moschen, Sebastián; Di Rienzo, Julio A; Higgins, Janet; Tohge, Takayuki; Watanabe, Mutsumi; González, Sergio; Rivarola, Máximo; García-García, Francisco; Dopazo, Joaquin; Hopp, H Esteban; Hoefgen, Rainer; Fernie, Alisdair R; Paniego, Norma; Fernández, Paula; Heinz, Ruth A

    2017-07-01

    By integration of transcriptional and metabolic profiles we identified pathways and hubs transcription factors regulated during drought conditions in sunflower, useful for applications in molecular and/or biotechnological breeding. Drought is one of the most important environmental stresses that effects crop productivity in many agricultural regions. Sunflower is tolerant to drought conditions but the mechanisms involved in this tolerance remain unclear at the molecular level. The aim of this study was to characterize and integrate transcriptional and metabolic pathways related to drought stress in sunflower plants, by using a system biology approach. Our results showed a delay in plant senescence with an increase in the expression level of photosynthesis related genes as well as higher levels of sugars, osmoprotectant amino acids and ionic nutrients under drought conditions. In addition, we identified transcription factors that were upregulated during drought conditions and that may act as hubs in the transcriptional network. Many of these transcription factors belong to families implicated in the drought response in model species. The integration of transcriptomic and metabolomic data in this study, together with physiological measurements, has improved our understanding of the biological responses during droughts and contributes to elucidate the molecular mechanisms involved under this environmental condition. These findings will provide useful biotechnological tools to improve stress tolerance while maintaining crop yield under restricted water availability.

  20. Communication equipment radiation resistance ensurance

    International Nuclear Information System (INIS)

    Myrova, L.O.; Chelizhenko, A.Z.

    1983-01-01

    A review of works on radiation resistance of electronic equipment (epsilon epsilon) for 15 years is presented. The effect of ionizing radiation appearing as a result of nuclear explosions in nuclear facilities and in outerspace on epsilon epsilon has been considered. Types of radiation effects in epsilon epsilon, radiation effect on semiconductor devices and integrated circUits, types of epsilon epsilon failures, as well as the procass of radiation-resistant epsilon epsilon designing and selection of its main parameters have been described. The methods of epsilon epsilon flowsheet optimization, application of mathematical simulation and peculiarities of ensurance of epsilon epsilon radiation resistance of communication systems are considered. Peculiarities of designing of radiation-resistant quartz generators, secondary power supply sources and amplifiers are discussed

  1. Retrofits for Energy Efficient Office Buildings: Integration of Optimized Photovoltaics in the Form of Responsive Shading Devices

    Directory of Open Access Journals (Sweden)

    Hardi K. Abdullah

    2017-11-01

    Full Text Available This study presents a retrofit strategy: integrating optimized photovoltaics (PV in the form of responsive shading devices using a dual-axis solar tracking system. A prototype-based model was fabricated to compare the efficiency of PV in this implementation with the conventional fixed installation. The office building, T1 Empire World in Erbil, was selected as a retrofit case study and for the application of the proposed integration system. In order to assess the effectiveness of the proposed retrofit method, the energy performance of the base case is simulated to be compared later with the energy performance simulations after the integration technique. The amount of generated electricity from the PV surfaces of the integrated shading elements is calculated. The energy simulations were performed using OpenStudio® (NREL, Washington, DC, USA, EnergyPlusTM (NREL, Washington, DC, USA, and Grasshopper/ Ladybug tools in which the essential results were recorded for the baseline reference, as well as the energy performance of the retrofitted building. The results emphasize that the PV-integrated responsive shading devices can maximize the efficiency of PV cells by 36.8% in comparison to the fixed installation. The integrated system can provide approximately 15.39% of the electricity demand for operating the building. This retrofit method has reduced the total site energy consumption by 33.2% compared to the existing building performance. Total electricity end-use of the various utilities was lowered by 33.5%, and the total natural gas end-use of heating demand was reduced by 30.9%. Therefore, the percentage reduction in electricity cooling demand in July and August is 42.7% due to minimizing the heat gain in summer through blocking the sun’s harsh rays from penetrating into interior spaces of the building. In general, this system has multiple benefits, starting with being extremely efficient and viable in generating sustainable alternative energy

  2. Development of remote handling tools and equipment

    International Nuclear Information System (INIS)

    Nakahira, Masataka; Oka, Kiyoshi; Taguchi, Kou; Ito, Akira; Fukatsu, Seiichi; Oda, Yasushi; Kajiura, Soji; Yamazaki, Seiichiro; Aoyama, Kazuo.

    1997-01-01

    The remote handling (RH) tools and equipment development in ITER focuses mainly on the welding and cutting technique, weld inspection and double-seal door which are essential factors in the replacement of in-vessel components such as divertor and blanket. The conceptual design of these RH tools and equipment has been defined through ITER engineering design activity (EDA). Similarly, elementary R and D of the RH tools and equipment have been extensively performed to accumulate a technological data base for process and performance qualification. Based on this data, fabrications of full-scale RH tools and equipment are under progress. A prototypical bore tool for pipe welding and cutting has already been fabricated and is currently undergoing integrated performance tests. This paper describes the design outline of the RH tools and equipment related to in-vessel components maintenance, and highlights the current status of RH tools and equipment development by the Japan Home Team as an ITER R and D program. This paper also includes an outline of insulation joint and quick-pipe connector development, which has also been conducted through the ITER R and D program in order to standardize RH operations and components. (author)

  3. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response.

    Science.gov (United States)

    Watson, Emma; MacNeil, Lesley T; Arda, H Efsun; Zhu, Lihua Julie; Walhout, Albertha J M

    2013-03-28

    Expression profiles are tailored according to dietary input. However, the networks that control dietary responses remain largely uncharacterized. Here, we combine forward and reverse genetic screens to delineate a network of 184 genes that affect the C. elegans dietary response to Comamonas DA1877 bacteria. We find that perturbation of a mitochondrial network composed of enzymes involved in amino acid metabolism and the TCA cycle affects the dietary response. In humans, mutations in the corresponding genes cause inborn diseases of amino acid metabolism, most of which are treated by dietary intervention. We identify several transcription factors (TFs) that mediate the changes in gene expression upon metabolic network perturbations. Altogether, our findings unveil a transcriptional response system that is poised to sense dietary cues and metabolic imbalances, illustrating extensive communication between metabolic networks in the mitochondria and gene regulatory networks in the nucleus. Copyright © 2013 Elsevier Inc. All rights reserved.

  4. Tornado Warning Perception and Response: Integrating the Roles of Visual Design, Demographics, and Hazard Experience.

    Science.gov (United States)

    Schumann, Ronald L; Ash, Kevin D; Bowser, Gregg C

    2018-02-01

    Recent advancements in severe weather detection and warning dissemination technologies have reduced, but not eliminated, large-casualty tornado hazards in the United States. Research on warning cognition and behavioral response by the public has the potential to further reduce tornado-related deaths and injuries; however, less research has been conducted in this area compared to tornado research in the physical sciences. Extant research in this vein tends to bifurcate. One branch of studies derives from classic risk perception, which investigates cognitive, affective, and sociocultural factors in relation to concern and preparation for uncertain risks. Another branch focuses on psychological, social, and cultural factors implicated in warning response for rapid onset hazards, with attention paid to previous experience and message design. Few studies link risk perceptions with cognition and response as elicited by specific examples of warnings. The present study unites risk perception, cognition, and response approaches by testing the contributions of hypothesized warning response drivers in one set of path models. Warning response is approximated by perceived fear and intended protective action as reported by survey respondents when exposed to hypothetical tornado warning scenarios. This study considers the roles of hazard knowledge acquisition, information-seeking behaviors, previous experience, and sociodemographic factors while controlling for the effects of the visual warning graphic. Findings from the study indicate the primacy of a user's visual interpretation of a warning graphic in shaping tornado warning response. Results also suggest that information-seeking habits, previous tornado experience, and local disaster culture play strong influencing roles in warning response. © 2017 Society for Risk Analysis.

  5. The Influence of Gravito-Inertial Force on Sensorimotor Integration and Reflexive Responses

    Science.gov (United States)

    Curthoys, Ian S.; Guedry, Fred E.; Merfeld, Daniel M.; Watt, Doug G. D.; Tomko, David L.; Wade, Charles E. (Technical Monitor)

    1994-01-01

    Sensorimotor responses (e.g.. eye movements, spinal reflexes, etc depend upon the interpretation of the neural signals from the sensory systems. Since neural signals from the otoliths may represent either tilt (gravity) or translation (linear inertial force), sensory signals from the otolith organs are necessarily somewhat ambiguous. Therefore. the neural responses to changing otolith signals depend upon the context of the stimulation (e.g- active vs. passive, relative orientation of gravity, etc.) as well as upon other sensory signals (e.g., vision. canals, etc.). This session will focus upon the -role -played by the sensory signals from the otolith organs in producing efficient sensorimotor and behavioral responses. Curthoys will show the influence of the peripheral anatomy and physiology. Tomko will discuss the influence of tilt and translational otolith signals on eye movements. Merfeld will demonstrate the rate otolith organs play during the interaction of sensory signals from the canals and otoliths. Watt will show the influence of the otoliths on spinal/postural responses. Guedry will discuss the contribution of vestibular information to "path of movement"' perception and to the development of a stable vertical reference. Sensorimotor responses to the ambiguous inertial force stimulation provide an important tool to investigate how the nervous system processes patterns of sensory information and yields functional sensorimotor responses.

  6. The strategic decisions and success factors of the global integration-local responsiveness of Japanese MNCs in China

    Institute of Scientific and Technical Information of China (English)

    MAO Yunshi; WANG Jiancheng

    2007-01-01

    This article applies Foreign Direct Investment (FDI) theories to the strategic management analysis of the global integration-local responsiveness of multinational corporations (MNCs) in China, from the perspective of company characteristics (ownership advantages and internalization advantages) and environmental dynamics (locational factors) in order to analyze the success factors influencing the sales activities of Japanese MNCs in China. Based on the analysis of a survey conducted on 230 Japanese parent companies with investments in China, the empirical research findings include: Japanese MNCs in China favor global integration strategies; the more significant the ownership advantages and internalization advantages are, the greater the global integration is; the success factors of their operations in China due to global integration are present in manufacturing know-how, procurement of parts and supplies, financial power, previous investment experience in China as well as sales networks and technologies; locational advantages mainly lie in labor cost among other things; internalization factors do not have any significant correlation with the success and performance of the subsidiary company.

  7. Highly localized distributed Brillouin scattering response in a photonic integrated circuit

    Science.gov (United States)

    Zarifi, Atiyeh; Stiller, Birgit; Merklein, Moritz; Li, Neuton; Vu, Khu; Choi, Duk-Yong; Ma, Pan; Madden, Stephen J.; Eggleton, Benjamin J.

    2018-03-01

    The interaction of optical and acoustic waves via stimulated Brillouin scattering (SBS) has recently reached on-chip platforms, which has opened new fields of applications ranging from integrated microwave photonics and on-chip narrow-linewidth lasers, to phonon-based optical delay and signal processing schemes. Since SBS is an effect that scales exponentially with interaction length, on-chip implementation on a short length scale is challenging, requiring carefully designed waveguides with optimized opto-acoustic overlap. In this work, we use the principle of Brillouin optical correlation domain analysis to locally measure the SBS spectrum with high spatial resolution of 800 μm and perform a distributed measurement of the Brillouin spectrum along a spiral waveguide in a photonic integrated circuit. This approach gives access to local opto-acoustic properties of the waveguides, including the Brillouin frequency shift and linewidth, essential information for the further development of high quality photonic-phononic waveguides for SBS applications.

  8. Improvements in remote equipment torquing and fastening

    International Nuclear Information System (INIS)

    Garin, J.

    1978-01-01

    Remote torquing and fastening is a requirement of generic interest for application in an environment not readily accessible to man. The developments over the last 30 years in torque-controlled equipment above 200 nm (150 ft/lb) have not been emphasized. The development of specialized subassemblies to torque and fasten equipment in a remotely controlled environment is an integral part of the Advanced Fuel Recycle Program at Oak Ridge National Laboratory. Commercially available subassemblies have been adapted into a system that would provide remote torquing and fastening in the range of 200 to 750 nm (150 to 550 ft/lb). 9 figures

  9. Visual communication and terminal equipment

    International Nuclear Information System (INIS)

    Kang, Cheol Hui

    1988-06-01

    This book is divided two parts about visual communication and terminal equipment. The first part introduces visual communication, which deals with foundation of visual communication, technique of visual communication, equipment of visual communication, a facsimile and pictorial image system. The second part contains terminal equipment such as telephone, terminal equipment for data transmission on constitution and constituent of terminal equipment for data transmission, input device and output device, terminal device and up-to-date terminal device.

  10. Visual communication and terminal equipment

    Energy Technology Data Exchange (ETDEWEB)

    Kang, Cheol Hui

    1988-06-15

    This book is divided two parts about visual communication and terminal equipment. The first part introduces visual communication, which deals with foundation of visual communication, technique of visual communication, equipment of visual communication, a facsimile and pictorial image system. The second part contains terminal equipment such as telephone, terminal equipment for data transmission on constitution and constituent of terminal equipment for data transmission, input device and output device, terminal device and up-to-date terminal device.

  11. What factors influence ward nurses' recognition of and response to patient deterioration? An integrative review of the literature.

    Science.gov (United States)

    Massey, Debbie; Chaboyer, Wendy; Anderson, Vinah

    2017-01-01

    In this integrative review, we aimed to: first, identify and summarize published studies relating to ward nurses' recognition of and response to patient deterioration; second, to critically evaluate studies that described or appraised the practice of ward nurses in recognizing and responding to patient deterioration; and third, identify gaps in the literature for further research. An integrative review. The Cumulative Index to Nursing and Allied Health Literature (CINAHL) Ovid Medline, Informit and Google Scholar databases were accessed for the years 1990-2014. Data were extracted and summarized in tables and then appraised using the Mixed Method Appraisal Tool. Data were grouped into two domains; recognizing and responding to deterioration and then thematic analysis was used to identify the emerging themes. Seventeen studies were reviewed and appraised. Recognizing patient deterioration was encapsulated in four themes: (1) assessing the patient; (2) knowing the patient; (3) education and (4) environmental factors. Responding to patient deterioration was encapsulated in three themes; (1) non-technical skills; (2) access to support and (3) negative emotional responses. Issues involved in timely recognition of and response to clinical deterioration remain complex, yet patient safety relies on nurses' timely assessments and actions.

  12. A chlorophyll fluorescence-based method for the integrated characterization of the photophysiological response to light stress.

    Science.gov (United States)

    Serôdio, João; Schmidt, William; Frankenbach, Silja

    2017-02-01

    This work introduces a new experimental method for the comprehensive description of the physiological responses to light of photosynthetic organisms. It allows the integration in a single experiment of the main established manipulative chlorophyll fluorescence-based protocols. It enables the integrated characterization of the photophysiology of samples regarding photoacclimation state (generating non-sequential light-response curves of effective PSII quantum yield, electron transport rate or non-photochemical quenching), photoprotection capacity (running light stress-recovery experiments, quantifying non-photochemical quenching components) and the operation of photoinactivation and photorepair processes (measuring rate constants of photoinactivation and repair for different light levels and the relative quantum yield of photoinactivation). The new method is based on a previously introduced technique, combining the illumination of a set of replicated samples with spatially separated actinic light beams of different intensity, and the simultaneous measurement of the fluorescence emitted by all samples using an imaging fluorometer. The main novelty described here is the independent manipulation of light intensity and duration of exposure for each sample, and the control of the cumulative light dose applied. The results demonstrate the proof of concept for the method, by comparing the responses of cultures of Chlorella vulgaris acclimated to low and high light regimes, highlighting the mapping of light stress responses over a wide range of light intensity and exposure conditions, and the rapid generation of paired light-response curves of photoinactivation and repair rate constants. This approach represents a chlorophyll fluorescence 'protocol of everything', contributing towards the high throughput characterization of the photophysiology of photosynthetic organisms. © The Author 2017. Published by Oxford University Press on behalf of the Society for Experimental

  13. Equipment cost optimization

    International Nuclear Information System (INIS)

    Ribeiro, E.M.; Farias, M.A.; Dreyer, S.R.B.

    1995-01-01

    Considering the importance of the cost of material and equipment in the overall cost profile of an oil company, which in the case of Petrobras, represents approximately 23% of the total operational cost or 10% of the sales, an organization for the optimization of such costs has been established within Petrobras. Programs are developed aiming at: optimization of life-cycle cost of material and equipment; optimization of industrial processes costs through material development. This paper describes the methodology used in the management of the development programs and presents some examples of concluded and ongoing programs, which are conducted in permanent cooperation with suppliers, technical laboratories and research institutions and have been showing relevant results

  14. X-ray equipment

    International Nuclear Information System (INIS)

    Redmayne, I.G.B.

    1988-01-01

    The patent concerns a warning and protection system for mobile x-ray equipment used for 'on site' radiography, so that workers in the vicinity of such a working unit can be alerted to its presence. The invention is a local repeater warning system which gives a preliminary warning that energisation of the tubehead is imminent, as well as a switch near the tubehead to abort or inhibit energisation. The latter switch allows personnel caught in the vicinity of the tubehead to prevent energisation. The preliminary warning may be flashing lamps or by a klaxon. The control unit for the equipment may include a monitoring circuit to detect failure of the warning light or klaxon. (U.K.)

  15. X-ray equipment

    Energy Technology Data Exchange (ETDEWEB)

    Redmayne, I.G.B.

    1988-01-06

    The patent concerns a warning and protection system for mobile x-ray equipment used for 'on site' radiography, so that workers in the vicinity of such a working unit can be alerted to its presence. The invention is a local repeater warning system which gives a preliminary warning that energisation of the tubehead is imminent, as well as a switch near the tubehead to abort or inhibit energisation. The latter switch allows personnel caught in the vicinity of the tubehead to prevent energisation. The preliminary warning may be flashing lamps or by a klaxon. The control unit for the equipment may include a monitoring circuit to detect failure of the warning light or klaxon. (U.K.).

  16. Tube for irradiation equipment

    International Nuclear Information System (INIS)

    Goehrich, K.; Vogt, H.

    1979-01-01

    This patent describes a tube for irradiation equipment for limiting an emergent beam, with a baseplate, possessing a central aperture, intended for attaching to the equipment, as well as four carrier plates, each of which possesses a limiting edge and a sliding edge located at right angles thereto. The carrier plates are located parallel to the baseplate, the limiting edge of each carrier plate resting against the sliding edge of the adjacent carrier plate and each of the two mutually opposite pairs of carrier plates being displaceable, parallel to the direction of its sliding edges and symmetrically to the center of the transmission aperture, for the purpose of continuously varying the transmission aperture defined by the limiting edges, during which displacement each of the displaced carrier plates carries with it the carrier plate, resting against the limiting edge of the former plate, parallel to the direction of the limiting edge of the latter plate. 8 claims

  17. Towards an integrative computational model for simulating tumor growth and response to radiation therapy

    Science.gov (United States)

    Marrero, Carlos Sosa; Aubert, Vivien; Ciferri, Nicolas; Hernández, Alfredo; de Crevoisier, Renaud; Acosta, Oscar

    2017-11-01

    Understanding the response to irradiation in cancer radiotherapy (RT) may help devising new strategies with improved tumor local control. Computational models may allow to unravel the underlying radiosensitive mechanisms intervening in the dose-response relationship. By using extensive simulations a wide range of parameters may be evaluated providing insights on tumor response thus generating useful data to plan modified treatments. We propose in this paper a computational model of tumor growth and radiation response which allows to simulate a whole RT protocol. Proliferation of tumor cells, cell life-cycle, oxygen diffusion, radiosensitivity, RT response and resorption of killed cells were implemented in a multiscale framework. The model was developed in C++, using the Multi-formalism Modeling and Simulation Library (M2SL). Radiosensitivity parameters extracted from literature enabled us to simulate in a regular grid (voxel-wise) a prostate cell tissue. Histopathological specimens with different aggressiveness levels extracted from patients after prostatectomy were used to initialize in silico simulations. Results on tumor growth exhibit a good agreement with data from in vitro studies. Moreover, standard fractionation of 2 Gy/fraction, with a total dose of 80 Gy as a real RT treatment was applied with varying radiosensitivity and oxygen diffusion parameters. As expected, the high influence of these parameters was observed by measuring the percentage of survival tumor cell after RT. This work paves the way to further models allowing to simulate increased doses in modified hypofractionated schemes and to develop new patient-specific combined therapies.

  18. Pressure integration technique for predicting wind-induced response in high-rise buildings

    Directory of Open Access Journals (Sweden)

    Aly Mousaad Aly

    2013-12-01

    Full Text Available This paper presents a procedure for response prediction in high-rise buildings under wind loads. The procedure is illustrated in an application example of a tall building exposed to both cross-wind and along-wind loads. The responses of the building in the lateral directions combined with torsion are estimated simultaneously. Results show good agreement with recent design standards; however, the proposed procedure has the advantages of accounting for complex mode shapes, non-uniform mass distribution, and interference effects from the surrounding. In addition, the technique allows for the contribution of higher modes. For accurate estimation of the acceleration response, it is important to consider not only the first two lateral vibrational modes, but also higher modes. Ignoring the contribution of higher modes may lead to underestimation of the acceleration response; on the other hand, it could result in overestimation of the displacement response. Furthermore, the procedure presented in this study can help decision makers, involved in a tall building design/retrofit to choose among innovative solutions like aerodynamic mitigation, structural member size adjustment, damping enhancement, and/or materials change, with an objective to improve the resiliency and the serviceability under extreme wind actions.

  19. A carbon dioxide avoidance behavior is integrated with responses to ambient oxygen and food in Caenorhabditis elegans.

    Science.gov (United States)

    Bretscher, Andrew Jonathan; Busch, Karl Emanuel; de Bono, Mario

    2008-06-10

    Homeostasis of internal carbon dioxide (CO2) and oxygen (O2) levels is fundamental to all animals. Here we examine the CO2 response of the nematode Caenorhabditis elegans. This species inhabits rotting material, which typically has a broad CO2 concentration range. We show that well fed C. elegans avoid CO2 levels above 0.5%. Animals can respond to both absolute CO2 concentrations and changes in CO2 levels within seconds. Responses to CO2 do not reflect avoidance of acid pH but appear to define a new sensory response. Sensation of CO2 is promoted by the cGMP-gated ion channel subunits TAX-2 and TAX-4, but other pathways are also important. Robust CO2 avoidance in well fed animals requires inhibition of the DAF-16 forkhead transcription factor by the insulin-like receptor DAF-2. Starvation, which activates DAF-16, strongly suppresses CO2 avoidance. Exposure to hypoxia (avoidance via activation of the hypoxia-inducible transcription factor HIF-1. The npr-1 215V allele of the naturally polymorphic neuropeptide receptor npr-1, besides inhibiting avoidance of high ambient O2 in feeding C. elegans, also promotes avoidance of high CO2. C. elegans integrates competing O2 and CO2 sensory inputs so that one response dominates. Food and allelic variation at NPR-1 regulate which response prevails. Our results suggest that multiple sensory inputs are coordinated by C. elegans to generate different coherent foraging strategies.

  20. Integrative omic analysis reveals distinctive cold responses in leaves and roots of strawberry, Fragaria × ananassa ‘Korona’

    Directory of Open Access Journals (Sweden)

    Gage eKoehler

    2015-10-01

    Full Text Available To assess underlying metabolic processes and regulatory mechanisms during cold exposure of strawberry, integrative omic approaches were applied to Fragaria × ananassa Duch. ‘Korona’. Both root and leaf tissues were examined for responses to the cold acclimation processes. Levels of metabolites, proteins, and transcripts in tissues from plants grown at 18°C were compared to those following 1 to 10 days of cold (2°C exposure. Overall, ‘Korona’ showed a modest increase of protective metabolites such as amino acids (aspartic acid, leucine, isoleucine, and valine, pentoses, phosphorylated and non-phosphorylated hexoses, and distinct compounds of the raffinose pathway (galactinol and raffinose. By 2DE proteomics a total of 845 spots were observed in leaves; 4.6% changed significantly in response to cold.Transcript levels in leaves were determined by microarray, where dozens of cold associated transcripts were quantitatively characterized, and levels of several potential key contributors (e.g., the dehydrin COR47 and GADb to cold tolerance were confirmed by qRT-PCR. Cold responses are placed within the existing knowledge base of low temperature stress change in plants, allowing an evaluation of the uniqueness or generality of Fragaria responses in photosynthetic tissues. Overall, the cold response characteristics of ‘Korona’ are consistent with a moderately cold tolerant plant.

  1. Equipment for isotope diagnostics

    International Nuclear Information System (INIS)

    Platz, W.

    1976-01-01

    The invention concerns an improvement of equipment for isotope diagnostics allowing to mark special intensity ranges of the recorded measurements by means of different colors. For undisturbed operation it is of advantage to avoid electric circuits between movable and unmovable parts of the color recorder. According to the invention, long gear wheels of glass fiber-reinforced polyamide are used for these connections. (ORU) [de

  2. Soviet equipment flies in

    CERN Multimedia

    CERN PhotoLab

    1978-01-01

    End of February 1977 a Soviet Ilyushin-76 heavy freight aircraft landed at Cointrin airport having on board fifty large wire proprtional chambers and associated apparatus, together weighing 10 tons, supplied by the Joint Institute for Nuclear Research, Dubna, USSR. The equipment was for the CERN- Dubna-Munich-Saclay experiment NA4 on deep inelastic muon scattering being set up in the North Area of SPS. See Weekly Bulletin 11/78.

  3. Labelling of equipment dispensers.

    Science.gov (United States)

    Gray, D C

    1993-01-01

    A new labelling system for use on medical equipment dispensers is tested. This system uses one of the objects stored in each unit of the dispenser as the 'label', by attaching it to the front of the dispenser with tape. The new system was compared to conventional written labelling by timing subjects asked to select items from two dispensers. The new system was 27% quicker than the conventional system. Images Fig. 1 PMID:8110335

  4. 30 CFR 250.517 - Tubing and wellhead equipment.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 2 2010-07-01 2010-07-01 false Tubing and wellhead equipment. 250.517 Section... Tubing and wellhead equipment. (a) No tubing string shall be placed in service or continue to be used unless such tubing string has the necessary strength and pressure integrity and is otherwise suitable for...

  5. Equipment Obsolescence Management Program

    Energy Technology Data Exchange (ETDEWEB)

    Redmond, J.

    2014-07-01

    Nuclear Power Plant (NPP) Operators are challenged with securing reliable supply channels for safety related equipment due to equipment obsolescence. Many Original Equipment Manufacturers (OEMs) have terminated production of spare parts and product life-cycle support. The average component life cycles are much shorter than the NPP design life, which means that replacement components and parts for the original NPP systems are not available for the complete design life of the NPPs. The lack or scarcity of replacement parts adversely affects plant reliability and ultimately the profitability of the affected NPPs. This problem is further compounded when NPPs pursue license renewal and approval for plant-life extension. A reliable and predictable supply of replacement co components is necessary for NPPs to remain economically competitive and meet regulatory requirements and guidelines. Electrical and I and C components, in particular, have short product life cycles and obsolescence issues must be managed pro actively and not reactively in order to mitigate the risk to the NPP to ensure reliable and economic NPP operation. (Author)

  6. Response Surface Methodology and Aspen Plus Integration for the Simulation of the Catalytic Steam Reforming of Ethanol

    Directory of Open Access Journals (Sweden)

    Bernay Cifuentes

    2017-01-01

    Full Text Available The steam reforming of ethanol (SRE on a bimetallic RhPt/CeO2 catalyst was evaluated by the integration of Response Surface Methodology (RSM and Aspen Plus (version 9.0, Aspen Tech, Burlington, MA, USA, 2016. First, the effect of the Rh–Pt weight ratio (1:0, 3:1, 1:1, 1:3, and 0:1 on the performance of SRE on RhPt/CeO2 was assessed between 400 to 700 °C with a stoichiometric steam/ethanol molar ratio of 3. RSM enabled modeling of the system and identification of a maximum of 4.2 mol H2/mol EtOH (700 °C with the Rh0.4Pt0.4/CeO2 catalyst. The mathematical models were integrated into Aspen Plus through Excel in order to simulate a process involving SRE, H2 purification, and electricity production in a fuel cell (FC. An energy sensitivity analysis of the process was performed in Aspen Plus, and the information obtained was used to generate new response surfaces. The response surfaces demonstrated that an increase in H2 production requires more energy consumption in the steam reforming of ethanol. However, increasing H2 production rebounds in more energy production in the fuel cell, which increases the overall efficiency of the system. The minimum H2 yield needed to make the system energetically sustainable was identified as 1.2 mol H2/mol EtOH. According to the results of the integration of RSM models into Aspen Plus, the system using Rh0.4Pt0.4/CeO2 can produce a maximum net energy of 742 kJ/mol H2, of which 40% could be converted into electricity in the FC (297 kJ/mol H2 produced. The remaining energy can be recovered as heat.

  7. Development of integrated-type dosimeter responsive to high energy neutrons (2)

    Energy Technology Data Exchange (ETDEWEB)

    Sawamura, Teruko; Murai, Ikuo; Abe, Masashi; Uoyama, Kazuya; Das, Mala [Hokkaido Univ., Sapporo, Hokkaido (Japan); Tuda, Shuichi [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2003-03-01

    The response of superheated drop detectors or bubble detectors (BDs) was measured for quasi-monoenergetic neutron beams in the 40-75 MeV range. The experiments were performed at the AVF cyclotron facility, TAKASAKI Ion Accelerator for Advanced Radiation Application (TIARA) of Japan Atomic Energy Research Institute (JAERI). The measured dose sensitivities showed to be lowered to about a half the nominal sensitivity. A lead-breeder introduced to extend response to the high energy region were investigated and compared with Monte Carlo calculations by MCNPX code. (author)

  8. Renewable generation and demand response integration in micro-grids. Development of a new energy management and control system

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez-Bel, C.; Escriva-Escriva, G.; Alcazar-Ortega, M. [Institute for Energy Engineering, Universitat Politecnica de Valencia, Valencia (Spain)

    2013-11-15

    The aim of this research resides in the development of an energy management and control system to control a micro-grid based on the use of renewable generation and demand resources to introduce the application of demand response concepts to the management of micro-grids in order to effectively integrate the demand side as an operation resource for the grid and improve energy efficiency of the elements. As an additional result, the evaluation of reductions in the total amount of CO2 emitted into the atmosphere due to the improvement of the energy efficiency of the system is assessed.

  9. A modified precise integration method based on Magnus expansion for transient response analysis of time varying dynamical structure

    International Nuclear Information System (INIS)

    Yue, Cong; Ren, Xingmin; Yang, Yongfeng; Deng, Wangqun

    2016-01-01

    This paper provides a precise and efficacious methodology for manifesting forced vibration response with respect to the time-variant linear rotational structure subjected to unbalanced excitation. A modified algorithm based on time step precise integration method and Magnus expansion is developed for instantaneous dynamic problems. The iterative solution is achieved by the ideology of transition and dimensional increment matrix. Numerical examples on a typical accelerating rotation system considering gyroscopic moment and mass unbalance force comparatively demonstrate the validity, effectiveness and accuracy with Newmark-β method. It is shown that the proposed algorithm has high accuracy without loss efficiency.

  10. An Integrated Multiperiod OPF Model with Demand Response and Renewable Generation Uncertainty

    DEFF Research Database (Denmark)

    Bukhsh, Waqquas Ahmed; Zhang, Chunyu; Pinson, Pierre

    2015-01-01

    Renewable energy sources such as wind and solar have received much attention in recent years, and large amount of renewable generation is being integrated to the electricity networks. A fundamental challenge in a power system operation is to handle the intermittent nature of the renewable...... that with small flexibility on the demand-side substantial benefits in terms of re-dispatch costs can be achieved. The proposed approach is tested on all standard IEEE test cases upto 300 buses for a wide variety of scenarios....

  11. Response of Non-Linear Systems to Renewal Impulses by Path Integration

    DEFF Research Database (Denmark)

    Nielsen, Søren R.K.; Iwankiewicz, R.

    The cell-to-cell mapping (path integration) technique has been devised for MDOF non-linear and non-hysteretic systems subjected to random trains of impulses driven by an ordinary renewal point process with gamma-distributed integer parameter interarrival times (an Erlang process). Since the renewal...... point process has not independent increments the state vector of the system, consisting of the generalized displacements and velocities, is not a Markov process. Initially it is shown how the indicated systems can be converted to an equivalent Poisson driven system at the expense of introducing...... additional discrete-valued state variables for which the stochastic equations are also formulated....

  12. Seismic qualification of nuclear equipment under multiple support excitations

    International Nuclear Information System (INIS)

    Neelwarne, A.; Kushwaha, H.S.; Kakodkar, A.

    1991-01-01

    ERS (Envelop Response Spectrum) is a conservative method for seismic analysis of equipment without overhang whereas it may severely underestimate the response, as compared to the time history response, for the case of overhanging equipment. However, MSRS (Multi Support Response Spectrum) method appears to give conservative results for both class of equipment. Inability to account a) magnification of response and b) contribution of antisymmetric modes resulting from relative support motion are found to be the reasons for unconservatism of ERS method. A simple criterion for selection of proper method, between ERS and MSRS, for the analysis of overhanging equipment is developed. The criterion is based on correlation of modal mass with the modal normal coordinate and is applicable to generalised equipment of non uniform mass and stiffness distribution. It is shown that; 1) MSRS method must be adopted if equipment first mode corresponds to vibration of overhanging masses. 2) MSRS method should be adopted if the modal mass for the first mode is less than 15 % of equipment mass. 3) Algebraic support group combination appears to give realistic results for the analysis of equipment. This is due to the dominant cantilever beam like behaviour of primary structure resulting in near in-phase motion at equipment supports. (author)

  13. Integrating Social Responsibility of University and Corporate Sector for Inclusive Growth in India

    Science.gov (United States)

    Singh, Seema

    2016-01-01

    Globalization has made the market in India very competitive. The lower segment of the workforce is under tremendous pressure to improve their productivity to sustain in the market. Being one of the important stakeholders, universities can play a very significant role in transferring knowledge created by them under their social responsibility. The…

  14. An integrated Markov decision process and nested logit consumer response model of air ticket pricing

    NARCIS (Netherlands)

    Lu, J.; Feng, T.; Timmermans, H.P.J.; Yang, Z.

    2017-01-01

    The paper attempts to propose an optimal air ticket pricing model during the booking horizon by taking into account passengers' purchasing behavior of air tickets. A Markov decision process incorporating a nested logit consumer response model is established to modeling the dynamic pricing process.

  15. Teaching Socially Valid Social Interaction Responses to Students with Severe Disabilities in an Integrated School Setting.

    Science.gov (United States)

    Nientimp, Edward G.; Cole, Christine L.

    1992-01-01

    Evaluated effects of procedure to teach appropriate social responses to adolescents with severe disabilities by employing ABA withdrawal design, replicated twice with two students, and AB design with third student. Results showed increases in correct responding and decreases in echolalia following intervention. Generalization of appropriate…

  16. Immigrant Children Promoting Environmental Care: Enhancing Learning, Agency and Integration through Culturally-Responsive Environmental Education

    Science.gov (United States)

    Blanchet-Cohen, Natasha; Reilly, Rosemary C.

    2017-01-01

    This paper examines the potential of culturally-responsive environmental education to engage immigrant early adolescents. Our study suggests that environmental involvement can become a means and an end for children to bridge their school and home in agential ways. Drawing from a multi-phase study involving focus groups with children, parents, and…

  17. Consumer Response to Product-Integrated Energy Feedback: Behavior, Goal Level Shifts and Energy Conservation

    NARCIS (Netherlands)

    McCalley, L.T.; de Vries, Pieter Walter; Midden, Cees J.H.

    2011-01-01

    Results of recent experiments suggest that interactive control panels of individual appliances can be used to stimulate energy saving behavior by offering the means for consumers to set a goal and receive immediate energy use feedback. The underlying source of the behavioral response, however,

  18. IT Tools for Foresight: The Integrated Insight and Response System of Deutsche Telekom Innovation Laboratories

    DEFF Research Database (Denmark)

    Rohrbeck, René; Thom, Nico; Arnold, Heinrich

    2015-01-01

    . The overall system consists of a tool for scanning for weak signals on change (PEACOQ Scouting Tool), a tool for collecting internal ideas (PEACOQ Gate 0.5), and a tool for triggering organizational responses (Foresight Landing page). Particularly the link to innovation management and R&D strategy...

  19. Integrating Responsible Conduct of Research Education into Undergraduate Biochemistry and Molecular Biology Laboratory Curricula

    Science.gov (United States)

    Hendrickson, Tamara L.

    2015-01-01

    Recently, a requirement for directed responsible conduct in research (RCR) education has become a priority in the United States and elsewhere. In the US, both the National Institutes of Health and the National Science Foundation require RCR education for all students who are financially supported by federal awards. The guidelines produced by these…

  20. Language Teaching and Technology Forum: The Integration of a Student Response System in Flipped Classrooms

    Science.gov (United States)

    Hung, Hsiu-Ting

    2017-01-01

    The present study incorporates a student response system (SRS) as a means to engage students in a flipped classroom and promote active learning. While the effectiveness of such systems with regard to student learning has been well documented in disciplines that are dominated by lecture-based instruction, no studies have compared the effectiveness…

  1. An Integrated Omics Analysis: Impact of Microgravity on Host Response to Lipopolysaccharide in vitro

    Science.gov (United States)

    2014-08-07

    on host response to lipopolysaccharide in vitro 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Nabarun Chakraborty...49. Mateescu B, Batista L, Cardon M, Gruosso T, de Feraudy Y, Mariani O, Nicolas A, Meyniel JP, Cottu P, Sastre Garau X, Mechta Grigoriou F: miR 141

  2. Fuels planning: science synthesis and integration; environmental consequences fact sheet 10: The Understory Response Model

    Science.gov (United States)

    Steve Sutherland; Melanie Miller

    2005-01-01

    The Understory Response Model is a species-specific computer model that qualitatively predicts change in total species biomass for grasses, forbs, and shrubs after thinning, prescribed fire, or wildfire. The model examines the effect of fuels management on plant survivorship and reproduction. This fact sheet identifies the intended users and uses, required inputs, what...

  3. Integrated Conceptual Design of Joined-Wing SensorCraft Using Response Surface Models

    Science.gov (United States)

    2006-11-01

    vi Acknowledgements I would like to express my sincere appreciation to my thesis advisor, Dr. Robert Canfield for his guidance and...55 Raymer Approximate and Group Weights Sizing Methods....................................... 57 Finite Element Model Structural Weight...Empty Weight Fraction Equation ............................... 54 Figure 29 Response of Refined Weight to T/W and W/S Inputs for Model (2) Raymer ASW

  4. Catchment response to lava damming: integrating field observation, geochronology and landscape evolution modelling

    NARCIS (Netherlands)

    Van Gorp, Wouter; Schoorl, Jeroen M.; Temme, Arnaud J. A. M.; Reimann, Tony; Wijbrans, Jan R.; Maddy, Darrel; Demir, Tuncer; Veldkamp, Tom

    2016-01-01

    Combining field reconstruction and landscape evolution modelling can be useful to investigate the relative role of different drivers on catchment response. The Geren Catchment (~45 km2) in western Turkey is suitable for such a study, as it has been influenced by uplift, climate change and lava

  5. Consumer response to product-integrated energy feedback : behavior, goal level shifts, and energy conservation

    NARCIS (Netherlands)

    McCalley, L.T.; Vries, de P.W.; Midden, C.J.H.

    2011-01-01

    Results of recent experiments suggest that interactive control panels of individual appliances can be used to stimulate energy saving behavior by offering the means for consumers to set a goal and receive immediate energy use feedback. The underlying source of the behavioral response, however,

  6. Propagating Molecular Recognition Events through Highly Integrated Sense-Response Chemical Systems

    Science.gov (United States)

    2017-08-01

    Gianneschi: 2015 Outstanding Young Scientist Award, ACS Applied Materials & Interfaces, PAT 2015 2016 Fellow of the Royal Society of Chemistry 2016...Tianfu Distinguished Lecturer in Polymer Science and Engineering , Sichuan University 2017 Blavatnik Young Scientist Award Finalist Protocol Activity...developing the basic polymer chemistry of responsive, biopolymer/polymer hybrid materials. This began with us generating a nobornyl-PNA (peptide

  7. Fuels planning: science synthesis and integration; environmental consequences fact sheet 15: The Wildlife Habitat Response Model

    Science.gov (United States)

    David Pilliod

    2005-01-01

    The Wildlife Habitat Response Model (WHRM) is a Web-based computer tool for evaluating the potential effects of fuel-reduction projects on terrestrial wildlife habitats. It uses species-habitat associations in ponderosa pine (Pinus ponderosa), dry-type Douglas-fir (Pseudotsuga menziesii), lodgepole pine (Pinus...

  8. Highly localized distributed Brillouin scattering response in a photonic integrated circuit

    Directory of Open Access Journals (Sweden)

    Atiyeh Zarifi

    2018-03-01

    Full Text Available The interaction of optical and acoustic waves via stimulated Brillouin scattering (SBS has recently reached on-chip platforms, which has opened new fields of applications ranging from integrated microwave photonics and on-chip narrow-linewidth lasers, to phonon-based optical delay and signal processing schemes. Since SBS is an effect that scales exponentially with interaction length, on-chip implementation on a short length scale is challenging, requiring carefully designed waveguides with optimized opto-acoustic overlap. In this work, we use the principle of Brillouin optical correlation domain analysis to locally measure the SBS spectrum with high spatial resolution of 800 μm and perform a distributed measurement of the Brillouin spectrum along a spiral waveguide in a photonic integrated circuit. This approach gives access to local opto-acoustic properties of the waveguides, including the Brillouin frequency shift and linewidth, essential information for the further development of high quality photonic-phononic waveguides for SBS applications.

  9. Responsible science: Ensuring the integrity of the research process, volume 1

    Science.gov (United States)

    This report thoughtfully examines the challenges posed in ensuring that the search for truth reflects adherence to ethical standards. In recent years, we have learned, sometimes painfully, that not all scientists adhere to this obligation. Reports of falsified research results and plagiarism involving both junior and senior scientists have stimulated doubts and criticism about the ways in which misconduct in science is addressed by the research community. Misconduct in science is now being publicly examined in all of its aspects; how misconduct is defined, the process by which misconduct is discovered, and procedures for judging innocence or guilt and assessing penalties. Also being explored are the appropriate roles of individuals, research institutions, journals, government research agencies, and the legal system. Issues of misconduct and integrity in science present complex questions. These issues require the sustained attention of all members of the research community as well as of leaders in the public and private sector who are concerned with safeguarding the health of science. In this regard ensuring the integrity of the research process is similar to assuring safety in the workplace: it is a process that requires continued participation from all levels of the entire research enterprise--the practitioners, the host institutions, the sponsors in government, and the legislators who provide the funds.

  10. Complementary responses to mean and variance modulations in the perfect integrate-and-fire model.

    Science.gov (United States)

    Pressley, Joanna; Troyer, Todd W

    2009-07-01

    In the perfect integrate-and-fire model (PIF), the membrane voltage is proportional to the integral of the input current since the time of the previous spike. It has been shown that the firing rate within a noise free ensemble of PIF neurons responds instantaneously to dynamic changes in the input current, whereas in the presence of white noise, model neurons preferentially pass low frequency modulations of the mean current. Here, we prove that when the input variance is perturbed while holding the mean current constant, the PIF responds preferentially to high frequency modulations. Moreover, the linear filters for mean and variance modulations are complementary, adding exactly to one. Since changes in the rate of Poisson distributed inputs lead to proportional changes in the mean and variance, these results imply that an ensemble of PIF neurons transmits a perfect replica of the time-varying input rate for Poisson distributed input. A more general argument shows that this property holds for any signal leading to proportional changes in the mean and variance of the input current.

  11. Integrative assessment of biomarker responses in teleostean fishes exposed to glyphosate-based herbicide (Excel Mera 71

    Directory of Open Access Journals (Sweden)

    Sukhendu Dey

    2016-12-01

    Full Text Available Present study deals with the effects of glyphosate-based herbicide, Excel Mera 71 on Anabas testudineus, Heteropnestes fossilis and Oreochromis niloticus in field conditions (1.85 kg/ha based on anti-oxidative, metabolic and digestive responses. For this study following biomarkers viz., acetylcholinesterase (AChE, lipid peroxidation (LPO, catalase (CAT, glutathione-S-transferase (GST, alkaline phosphatase (ALP, aspartate aminotransferase (AST, alanine aminotransferase (ALT, amylase, lipase and protease were investigated in gill, stomach, intestine, liver, kidney, brain, muscle and spinal cord of the concerned fish species. Enzyme activities were significantly altered by glyphosate exposure after 30 days, these activities were tissue as well as species specific. The results suggested that these biomarkers could be used to assess the ecological risks of glyphosate on fish. Bioaccumulation factor (BAF studied in different aquatic natural macrophytes showed order of Alternanthera philoxeroides > Azolla pinnata > Lemna sp. (Minor > Lemna sp. (Major > Pistia stratiotes, while transfer factor (TF showed the order of Pistia stratiotes > Alternanthera philoxeroides > Lemna sp. Bioconcentration factor (BCF study showed maximum accumulation of glyphosate in liver, kidney or intestine, and minimum either in bone or stomach irrespective of fish species. An integrated biomarker response (IBR, which uses a battery of biomarkers to calculate the standardized scores for each biomarker responses ranging from physiological to biochemical/molecular responses, was evaluated by combining the multiple biomarkers into a single value to evaluate quantitatively the toxicological effects of glyphosate. In general, the multiple indices exhibited variations and A. testudineus was more affected than other fish species; maximum IBR value was observed for LPO and minimum in case of ALT. The order of integrated biomarkers caused by glyphosate treatment was

  12. Integration of white matter network is associated with interindividual differences in psychologically mediated placebo response in migraine patients.

    Science.gov (United States)

    Liu, Jixin; Ma, Shaohui; Mu, Junya; Chen, Tao; Xu, Qing; Dun, Wanghuan; Tian, Jie; Zhang, Ming

    2017-10-01

    Individual differences of brain changes of neural communication and integration in the modular architecture of the human brain network exist for the repeated migraine attack and physical or psychological stressors. However, whether the interindividual variability in the migraine brain connectome predicts placebo response to placebo treatment is still unclear. Using DTI and graph theory approaches, we systematically investigated the topological organization of white matter networks in 71 patients with migraine without aura (MO) and 50 matched healthy controls at three levels: global network measure, nodal efficiency, and nodal intramodule/intermodule efficiency. All patients participated in an 8-week sham acupuncture treatment to induce analgesia. In our results, 30% (n = 21) of patients had 50% change in migraine days from baseline after placebo treatment. At baseline, abnormal increased network integration was found in MO patients as compared with the HC group, and the increased global efficiency before starting clinical treatment was associated with their following placebo response. For nodal efficiency, significantly increased within-subnetwork nodal efficiency and intersubnetwork connectivity of the hippocampus and middle frontal gyrus in patients' white matter network were correlated with the responses of follow-up placebo treatment. Our findings suggested that the trait-like individual differences in pain-related maladaptive stress interfered with and diminished the capacity of chronic pain modulation differently, and the placebo response for treatment could be predicted from a prior white matter network modular structure in migraineurs. Hum Brain Mapp 38:5250-5259, 2017. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  13. Review of Real-time Electricity Markets for Integrating Distributed Energy Resources and Demand Response

    DEFF Research Database (Denmark)

    Wang, Qi; Zhang, Chunyu; Ding, Yi

    2015-01-01

    The high penetration of both Distributed Energy Resources (DER) and Demand Response (DR) in modern power systems requires a sequence of advanced strategies and technologies for maintaining system reliability and flexibility. Real-time electricity markets (RTM) are the nondiscriminatory transaction...... platforms for providing necessary balancing services, where the market clearing (nodal or zonal prices depending on markets) is very close to real time operations of power systems. One of the primary functions of RTMs in modern power systems is establishing an efficient and effective mechanism for small DER...... and DR to participate in balancing market transactions, while handling their meteorological or intermittent characteristics, facilitating asset utilization, and stimulating their active responses. Consequently, RTMs are dedicated to maintaining the flexibility and reliability of power systems. This paper...

  14. Integrated transcriptomic and proteomic analysis of the bile stress response in probiotic Lactobacillus salivarius LI01.

    Science.gov (United States)

    Lv, Long-Xian; Yan, Ren; Shi, Hai-Yan; Shi, Ding; Fang, Dai-Qiong; Jiang, Hui-Yong; Wu, Wen-Rui; Guo, Fei-Fei; Jiang, Xia-Wei; Gu, Si-Lan; Chen, Yun-Bo; Yao, Jian; Li, Lan-Juan

    2017-01-06

    Lactobacillus salivarius LI01, isolated from healthy humans, has demonstrated probiotic properties in the prevention and treatment of liver failure. Tolerance to bile stress is crucial to allow lactobacilli to survive in the gastrointestinal tract and exert their benefits. In this work, we used a Digital Gene Expression transcriptomic and iTRAQ LC-MS/MS proteomic approach to examine the characteristics of LI01 in response to bile stress. Using culture medium with or without 0.15% ox bile, 591 differentially transcribed genes and 347 differentially expressed proteins were detected in LI01. Overall, we found the bile resistance of LI01 to be based on a highly remodeled cell envelope and a reinforced bile efflux system rather than on the activity of bile salt hydrolases. Additionally, some differentially expressed genes related to regulatory systems, the general stress response and central metabolism processes, also play roles in stress sensing, bile-induced damage prevention and energy efficiency. Moreover, bile salts appear to enhance proteolysis and amino acid uptake (especially aromatic amino acids) by LI01, which may support the liver protection properties of this strain. Altogether, this study establishes a model of global response mechanism to bile stress in L. salivarius LI01. L. salivarius strain LI01 exhibits not only antibacterial and antifungal properties but also exerts a good health-promoting effect in acute liver failure. As a potential probiotic strain, the bile-tolerance trait of strain LI01 is important, though this has not yet been explored. In this study, an analysis based on DGE and iTRAQ was performed to investigate the gene expression in strain LI01 under bile stress at the mRNA and protein levels, respectively. To our knowledge, this work also represents the first combined transcriptomic and proteomic analysis of the bile stress response mechanism in L. salivarius. Copyright © 2016. Published by Elsevier B.V.

  15. Nuclear emergency response exercises and decision support systems - integrating domestic experience with international reference systems

    International Nuclear Information System (INIS)

    Slavnicu, D.S.; Vamanu, D.V.; Gheorghiu, D.; Acasandrei, V.T.; Slavnicu, E.

    2010-01-01

    The paper glosses on the experience of a research-oriented team routinely involved in emergency preparedness and response management activities, with the assimilation, implementation, and application of decision support systems (DSS) of continental reference in Europe, and the development of supportive, domestic radiological assessment tools. Two exemplary nuclear alert exercises are discussed, along with solutions that emerged during drill planning and execution, to make decision support tools of various origins and strength to work synergistically and complement each other. (authors)

  16. Using smart meter data to estimate demand response potential, with application to solar energy integration

    International Nuclear Information System (INIS)

    Dyson, Mark E.H.; Borgeson, Samuel D.; Tabone, Michaelangelo D.; Callaway, Duncan S.

    2014-01-01

    This paper presents a new method for estimating the demand response potential of residential air conditioning (A/C), using hourly electricity consumption data (“smart meter” data) from 30,000 customer accounts in Northern California. We apply linear regression and unsupervised classification methods to hourly, whole-home consumption and outdoor air temperature data to determine the hours, if any, that each home's A/C is active, and the temperature dependence of consumption when it is active. When results from our sample are scaled up to the total population, we find a maximum of 270–360 MW (95% c.i.) of demand response potential over a 1-h duration with a 4 °F setpoint change, and up to 3.2–3.8 GW of short-term curtailment potential. The estimated resource correlates well with the evening decline of solar production on hot, summer afternoons, suggesting that demand response could potentially act as reserves for the grid during these periods in the near future with expected higher adoption rates of solar energy. Additionally, the top 5% of homes in the sample represent 40% of the total MW-hours of DR resource, suggesting that policies and programs to take advantage of this resource should target these high users to maximize cost-effectiveness. - Highlights: • We use hourly electricity use data to estimate residential demand response (DR) potential. • The residential cooling DR resource is large and well-matched to solar variability. • Customer heterogeneity is large; programs should target high potential customers

  17. Firms’ corporate social responsibility behavior: An integration of institutional and profit maximization approaches

    OpenAIRE

    Susan L Young; Mona V Makhija

    2014-01-01

    Understanding firms’ behavior across countries – a key concern in the international business literature – requires the joint consideration of both institutional influences and firms’ profit maximization goals. In the corporate social responsibility (CSR) area, however, researchers have utilized theories that take into account only one or the other – institutional theory, which explains CSR as legitimacy-seeking activities in line with national-level institutions, or economic-based approaches ...

  18. A review of integrating electroactive polymers as responsive systems for specialized drug delivery applications.

    Science.gov (United States)

    Pillay, Viness; Tsai, Tong-Sheng; Choonara, Yahya E; du Toit, Lisa C; Kumar, Pradeep; Modi, Girish; Naidoo, Dinesh; Tomar, Lomas K; Tyagi, Charu; Ndesendo, Valence M K

    2014-06-01

    Electroactive polymers (EAPs) are promising candidate materials for the design of drug delivery technologies, especially in conditions where an "on-off" drug release mechanism is required. To achieve this, EAPs such as polyaniline, polypyrrole, polythiophene, ethylene vinyl acetate, and polyethylene may be blended into responsive hydrogels in conjunction with the desired drug to obtain a patient-controlled drug release system. The "on-off" drug release mechanism can be achieved through the environmental-responsive nature of the interpenetrating hydrogel-EAP complex via (i) charged ions initiated diffusion of drug molecules; (ii) conformational changes that occur during redox switching of EAPs; or (iii) electroerosion. These release mechanisms are not exhaustive and new release mechanisms are still under investigation. Therefore, this review seeks to provide a concise incursion and critical overview of EAPs and responsive hydrogels as a strategy for advanced drug delivery, for example, controlled release of neurotransmitters, sulfosalicyclic acid from cross-linked hydrogel, and vaccine delivery. The review further discusses techniques such as linear sweep voltammetry, cyclic voltammetry, impedance spectroscopy, and chronoamperometry for the determination of the redox capability of EAPs. The future implications of the hydrogel-EAP composites include, but not limited to, application toward biosensors, DNA hybridizations, microsurgical tools, and miniature bioreactors and may be utilized to their full potential in the form of injectable devices as nanorobots or nanobiosensors. Copyright © 2013 Wiley Periodicals, Inc.

  19. Integrated watershed-scale response to climate change for selected basins across the United States

    Science.gov (United States)

    Markstrom, Steven L.; Hay, Lauren E.; Ward-Garrison, D. Christian; Risley, John C.; Battaglin, William A.; Bjerklie, David M.; Chase, Katherine J.; Christiansen, Daniel E.; Dudley, Robert W.; Hunt, Randall J.; Koczot, Kathryn M.; Mastin, Mark C.; Regan, R. Steven; Viger, Roland J.; Vining, Kevin C.; Walker, John F.

    2012-01-01

    A study by the U.S. Geological Survey (USGS) evaluated the hydrologic response to different projected carbon emission scenarios of the 21st century using a hydrologic simulation model. This study involved five major steps: (1) setup, calibrate and evaluated the Precipitation Runoff Modeling System (PRMS) model in 14 basins across the United States by local USGS personnel; (2) acquire selected simulated carbon emission scenarios from the World Climate Research Programme's Coupled Model Intercomparison Project; (3) statistical downscaling of these scenarios to create PRMS input files which reflect the future climatic conditions of these scenarios; (4) generate PRMS projections for the carbon emission scenarios for the 14 basins; and (5) analyze the modeled hydrologic response. This report presents an overview of this study, details of the methodology, results from the 14 basin simulations, and interpretation of these results. A key finding is that the hydrological response of the different geographical regions of the United States to potential climate change may be different, depending on the dominant physical processes of that particular region. Also considered is the tremendous amount of uncertainty present in the carbon emission scenarios and how this uncertainty propagates through the hydrologic simulations.

  20. Transparency in authors' contributions and responsibilities to promote integrity in scientific publication.

    Science.gov (United States)

    McNutt, Marcia K; Bradford, Monica; Drazen, Jeffrey M; Hanson, Brooks; Howard, Bob; Jamieson, Kathleen Hall; Kiermer, Véronique; Marcus, Emilie; Pope, Barbara Kline; Schekman, Randy; Swaminathan, Sowmya; Stang, Peter J; Verma, Inder M

    2018-03-13

    In keeping with the growing movement in scientific publishing toward transparency in data and methods, we propose changes to journal authorship policies and procedures to provide insight into which author is responsible for which contributions, better assurance that the list is complete, and clearly articulated standards to justify earning authorship credit. To accomplish these goals, we recommend that journals adopt common and transparent standards for authorship, outline responsibilities for corresponding authors, adopt the Contributor Roles Taxonomy (CRediT) (docs.casrai.org/CRediT) methodology for attributing contributions, include this information in article metadata, and require authors to use the ORCID persistent digital identifier (https://orcid.org). Additionally, we recommend that universities and research institutions articulate expectations about author roles and responsibilities to provide a point of common understanding for discussion of authorship across research teams. Furthermore, we propose that funding agencies adopt the ORCID identifier and accept the CRediT taxonomy. We encourage scientific societies to further authorship transparency by signing on to these recommendations and promoting them through their meetings and publications programs. Copyright © 2018 the Author(s). Published by PNAS.