CRC-113 gene expression signature for predicting prognosis in patients with colorectal cancer.

Science.gov (United States)

Nguyen, Minh Nam; Choi, Tae Gyu; Nguyen, Dinh Truong; Kim, Jin-Hwan; Jo, Yong Hwa; Shahid, Muhammad; Akter, Salima; Aryal, Saurav Nath; Yoo, Ji Youn; Ahn, Yong-Joo; Cho, Kyoung Min; Lee, Ju-Seog; Choe, Wonchae; Kang, Insug; Ha, Joohun; Kim, Sung Soo

2015-10-13

Colorectal cancer (CRC) is the third leading cause of global cancer mortality. Recent studies have proposed several gene signatures to predict CRC prognosis, but none of those have proven reliable for predicting prognosis in clinical practice yet due to poor reproducibility and molecular heterogeneity. Here, we have established a prognostic signature of 113 probe sets (CRC-113) that include potential biomarkers and reflect the biological and clinical characteristics. Robustness and accuracy were significantly validated in external data sets from 19 centers in five countries. In multivariate analysis, CRC-113 gene signature showed a stronger prognostic value for survival and disease recurrence in CRC patients than current clinicopathological risk factors and molecular alterations. We also demonstrated that the CRC-113 gene signature reflected both genetic and epigenetic molecular heterogeneity in CRC patients. Furthermore, incorporation of the CRC-113 gene signature into a clinical context and molecular markers further refined the selection of the CRC patients who might benefit from postoperative chemotherapy. Conclusively, CRC-113 gene signature provides new possibilities for improving prognostic models and personalized therapeutic strategies.

PSA Review Handbook

International Nuclear Information System (INIS)

Hallman, Anders; Nyman, Ralph; Knochenhauer, Michael

2004-05-01

The Swedish Nuclear Power Inspectorate (SKI) expresses requirements on the performance of PSAs as well as on PSA activities in general in the the regulatory document 'Regulations Concerning Safety in Certain Nuclear Facilities', SKlFS 1998:1. The follow-up of these activities is part of the inspection tasks of the SKI. In view or this, there is a need for documented guidelines on now to perform these inspections and reviews. The SKI PSA Review Handbook is intended to be a support in the SKI inspection and control of the PSA activities or the licensees. These PSA activities include both the organisation and working procedures of the licensee, the layout and contents of the PSA, and its areas of application. Using the regulation SKIFS 1998:1 as a starting point, the review handbook presents important aspects to be considered when judging whether a licensee fulfils the requirements on PSA activities, including the performance of PSA:s or PSA applications. The handbook shall also be a guidance for the review of PSA:s. However, the intention of the PSA Review Handbook is not to be a handbook for how a PSA is performed. The PSA Review Handbook is applicable to all types or initiating events and all operating conditions, and has been structured in a way, which stresses the integrated characteristics of PSA in the creation of the risk picture of a plant. The PSA Review Handbook has been based on the requirements for PSA of nuclear power plants, as this is the most extensive application. However, the relevant parts of it are also applicable when analysing other nuclear installations. The PSA Review Handbook is published as a research report as its contents are judged to be of general interest, and the SKI welcomes comments to the handbook. An update or the PSA Review Handbook may be required as experience with the use of the handbook is acquired and if general PSA requirements change

CRC concise encyclopedia of mathematics

CERN Document Server

Weisstein, Eric W

2003-01-01

Upon publication, the first edition of the CRC Concise Encyclopedia of Mathematics received overwhelming accolades for its unparalleled scope, readability, and utility. It soon took its place among the top selling books in the history of Chapman & Hall/CRC, and its popularity continues unabated. Yet also unabated has been the dedication of author Eric Weisstein to collecting, cataloging, and referencing mathematical facts, formulas, and definitions. He has now updated most of the original entries and expanded the Encyclopedia to include 1000 additional pages of illustrated entries. The accessibility of the Encyclopedia along with its broad coverage and economical price make it attractive to the widest possible range of readers and certainly a must for libraries, from the secondary to the professional and research levels. For mathematical definitions, formulas, figures, tabulations, and references, this is simply the most impressive compendium available.

Genetic diagnosis of high-penetrance susceptibility for colorectal cancer (CRC) is achievable for a high proportion of familial CRC by exome sequencing.

Science.gov (United States)

Chubb, Daniel; Broderick, Peter; Frampton, Matthew; Kinnersley, Ben; Sherborne, Amy; Penegar, Steven; Lloyd, Amy; Ma, Yussanne P; Dobbins, Sara E; Houlston, Richard S

2015-02-10

Knowledge of the contribution of high-penetrance susceptibility to familial colorectal cancer (CRC) is relevant to the counseling, treatment, and surveillance of CRC patients and families. To quantify the impact of germline mutation to familial CRC, we sequenced the mismatch repair genes (MMR) APC, MUTYH, and SMAD4/BMPR1A in 626 early-onset familial CRC cases ascertained through a population-based United Kingdom national registry. In addition, we evaluated the contribution of mutations in the exonuclease domain (exodom) of POLE and POLD1 genes that have recently been reported to confer CRC risk. Overall mutations (pathogenic, likely pathogenic) in MMR genes make the highest contribution to familial CRC (10.9%). Mutations in the other established CRC genes account for 3.3% of cases. POLE/POLD1 exodom mutations were identified in three patients with family histories consistent with dominant transmission of CRC. Collectively, mutations in the known genes account for 14.2% of familial CRC (89 of 626 cases; 95% CI = 11.5, 17.2). A genetic diagnosis is feasible in a high proportion of familial CRC. Mainstreaming such analysis in clinical practice should enable the medical management of patients and their families to be optimized. Findings suggest CRC screening of POLE and POLD1 mutation carriers should be comparable to that afforded to those at risk of HNPCC. Although the risk of CRC associated with unexplained familial CRC is in general moderate, in some families the risk is substantive and likely to be the consequence of unidentified genes, as exemplified by POLE and POLD1. Our findings have utility in the design of genetic analyses to identify such novel CRC risk genes. © 2015 by American Society of Clinical Oncology.

Upregulated STAT3 and RhoA signaling in colorectal cancer (CRC) regulate the invasion and migration of CRC cells.

Science.gov (United States)

Zhang, G-Y; Yang, W-H; Chen, Z

2016-05-01

We aimed to reveal the expression and activation of signal transducers and activators of transcription 3 (STAT3) and RhoA/Rho-associated coiled-coil forming kinase 1 (ROCK1) signaling in CRC tissues, and to investigate the regulatory role of STAT3 and RhoA signaling in the invasion and migration of colorectal cancer cells. We examined the expression of STAT3, RhoA and ROCK1 in CRC tissues with real-time PCR and Western blotting methods. And then we examined the interaction between STAT3 and RhoA/ROCK1 signaling in CRC HT-29 cells with gain-of-function and loss-of-function strategies. In addition, we determined the regulation by STAT3 and RhoA/ROCK1 on the invasion and migration of CRC HT-29 cells. Our study demonstrated a significant upregulation of RhoA and ROCK1 expression and STAT3-Y705 phosphorylation in 32 CRC specimens, compared to the 17 normal CRC tissues. Further study demonstrated there was a coordination between STAT3 and RhoA/Rock signaling in the HT-29 cells. Moreover, STAT3 knockdown or RhoA knockdown significantly repressed the migration and invasion in HT-29 cells and vice versa. STAT3 and RhoA signaling regulate the invasion and migration of CRC cells, implying the orchestrated and oncogenic roles of STAT3 and RhoA/ROCK1 signaling in CRC.

Tape Storage and CRC Protection

CERN Document Server

Ha, Karel

2014-01-01

Over 100 Petabytes of data is stored on several kind of physical support, namely disks and tapes. Data on any physical support or traveling on a data link (network, fibre channel...) can be subject to silent data corruption. A possible improvement is introducing end-to-end data integrity from the filesystem down to the tape layer. For the tape back-end it can be done by using Logical Block Protection, which computes and compares CRC checksum of every single block of data. During my work, I improved on-the-fly CRC calculation for the tape storage system, which was achieved by introducing a multithreaded implementation - a technique applicable to arbitrary CRC algorithm. Finally, I per...

Shell petroleum handbook. [Glossary included

Energy Technology Data Exchange (ETDEWEB)

1986-01-01

The present edition has been completely updated and revised, reflecting the very great changes which have come about in the oil industry over the last 18 years, since the last edition appeared. The expressed aim of the Handbook is to combine explanations of the processes of today's petroleum industry, from crude oil exploration to product end-use, with some historical background and explanation of the economic context in which the oil, gas and petrochemical industries operate. It is therefore intended as a technical reference manual, although it will be of interest both to specialists in search of information outside their expertise and to the more general reader. Chapter 3, entitled Exploration and Production, is concerned with structural geology, exploration methods and theory, and reservoir engineering, although the economic and financial aspects of drilling, project management and communication logistics are also considered. Other chapters are devoted to the distribution, consumption and end use of natural gas and NGL, the chemistry of petroleum, the manufacture of oil products, marketing, supply and trading, petrochemicals, synfuels, R and D, environmental conservation, and introduction to the world petroleum industry, and a review of oil and gas in the centrally planned economies, although only the Soviet Union is considered in any detail.

Gen IV Materials Handbook Implementation Plan

International Nuclear Information System (INIS)

Rittenhouse, P.; Ren, W.

2005-01-01

A Gen IV Materials Handbook is being developed to provide an authoritative single source of highly qualified structural materials information and materials properties data for use in design and analyses of all Generation IV Reactor Systems. The Handbook will be responsive to the needs expressed by all of the principal government, national laboratory, and private company stakeholders of Gen IV Reactor Systems. The Gen IV Materials Handbook Implementation Plan provided here addresses the purpose, rationale, attributes, and benefits of the Handbook and will detail its content, format, quality assurance, applicability, and access. Structural materials, both metallic and ceramic, for all Gen IV reactor types currently supported by the Department of Energy (DOE) will be included in the Gen IV Materials Handbook. However, initial emphasis will be on materials for the Very High Temperature Reactor (VHTR). Descriptive information (e.g., chemical composition and applicable technical specifications and codes) will be provided for each material along with an extensive presentation of mechanical and physical property data including consideration of temperature, irradiation, environment, etc. effects on properties. Access to the Gen IV Materials Handbook will be internet-based with appropriate levels of control. Information and data in the Handbook will be configured to allow search by material classes, specific materials, specific information or property class, specific property, data parameters, and individual data points identified with materials parameters, test conditions, and data source. Details on all of these as well as proposed applicability and consideration of data quality classes are provided in the Implementation Plan. Website development for the Handbook is divided into six phases including (1) detailed product analysis and specification, (2) simulation and design, (3) implementation and testing, (4) product release, (5) project/product evaluation, and (6) product

More comprehensive discussion of CRC screening associated with higher screening.

Science.gov (United States)

Mosen, David M; Feldstein, Adrianne C; Perrin, Nancy A; Rosales, A Gabriella; Smith, David H; Liles, Elizabeth G; Schneider, Jennifer L; Meyers, Ronald E; Elston-Lafata, Jennifer

2013-04-01

Examine association of comprehensiveness of colorectal cancer (CRC) screening discussion by primary care physicians (PCPs) with completion of CRC screening. Observational study in Kaiser Permanente Northwest, a group-model health maintenance organization. A total of 883 participants overdue for CRC screening received an automated telephone call (ATC) between April and June 2009 encouraging CRC screening. Between January and March 2010, participants completed a survey on PCPs' discussion of CRC screening and patient beliefs regarding screening. receipt of CRC screening (assessed by electronic medical record [EMR], 9 months after ATC). Primary independent variable: comprehensiveness of CRC screening discussion by PCPs (7-item scale). Secondary independent variables: perceived benefits of screening (4-item scale assessing respondents' agreement with benefits of timely screening) and primary care utilization (EMR; 9 months after ATC). The independent association of variables with CRC screening was assessed with logistic regression. Average scores for comprehensiveness of CRC discussion and perceived benefits were 0.4 (range 0-1) and 4.0 (range 1-5), respectively. A total of 28.2% (n = 249) completed screening, 84% of whom had survey assessments after their screening date. Of screeners, 95.2% completed the fecal immunochemical test. More comprehensive discussion of CRC screening was associated with increased screening (odds ratio [OR] = 1.51, 95% confidence interval [CI] = 1.03-2.21). Higher perceived benefits (OR = 1.46, 95% CI = 1.13-1.90) and 1 or more PCP visits (OR = 5.82, 95% CI = 3.87-8.74) were also associated with increased screening. More comprehensive discussion of CRC screening was independently associated with increased CRC screening. Primary care utilization was even more strongly associated with CRC screening, irrespective of discussion of CRC screening.

12 CFR 617.7315 - What records must the qualified lender maintain on behalf of the CRC?

Science.gov (United States)

2010-01-01

... on behalf of the CRC? 617.7315 Section 617.7315 Banks and Banking FARM CREDIT ADMINISTRATION FARM... must the qualified lender maintain on behalf of the CRC? A qualified lender must maintain a complete file of all requests for CRC reviews, including participation in state mediation programs, the minutes...

How does the serrated polyp pathway alter CRC screening and surveillance?

Science.gov (United States)

Kahi, Charles J

2015-03-01

Screening and surveillance for colorectal cancer (CRC) reduces mortality through the detection of early-stage adenocarcinoma, and more importantly the detection and removal of premalignant polyps. While adenomas have historically been considered the most common and screening-relevant precursor lesions, there is accumulating evidence showing that the serrated pathway is an important contributor to CRC, and a disproportionate contributor to interval or postcolonoscopy CRC, particularly in the proximal colon. The serrated pathway is characterized by mutations in the BRAF gene, high levels of methylation of promoter CpG islands (CIMP-high), and the sessile serrated adenoma/polyp (SSA/P) is the most important precursor lesion. The study of serrated polyps has been complicated by evolving nomenclature, substantial variation among pathologists in the identification of SSA/Ps, high variability in endoscopic detection rates, and uncertainty regarding the relation to synchronous and metachronous colonic neoplasia. This paper presents an overview of the serrated polyp pathway and discusses its clinical implications including its impact on CRC screening.

Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance.

Science.gov (United States)

Krzystek-Korpacka, Malgorzata; Diakowska, Dorota; Kapturkiewicz, Bartosz; Bębenek, Marek; Gamian, Andrzej

2013-08-28

Alternate colorectal cancer (CRC) screening and surveillance strategies are needed to pre-select candidates for invasive methods. We compared systemic inflammatory profiles in CRC (n=99), health (n=98), high CRC-risk conditions (n=48) and overt inflammation (n=69) by multiplexed analysis of IL-1β, IL-6, IL-8, FGF-2, G-CSF, GM-CSF, MCP-1, MIP-1α, TNF-α, VEGF-A, and PDGF-B and CEA. Cytokines corresponded with CRC advancement. FGF2, GM-CSF, IL-1β, IL-6, MIP-1α, PDGF-BB, TNF-α, and VEGF-A were higher than in controls already in stage I CRC with FGF2, IL1-β, and MIP-1α higher than in high CRC-risk individuals as well. Cytokine panels devised to differentiate early CRC from controls, adenomas, or inflammatory bowel disease patients (IBD) had good accuracy but only IBD panel had promising specificity at 95% sensitivity. Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

Fault isolation through no-overhead link level CRC

Science.gov (United States)

Chen, Dong; Coteus, Paul W.; Gara, Alan G.

2007-04-24

A fault isolation technique for checking the accuracy of data packets transmitted between nodes of a parallel processor. An independent crc is kept of all data sent from one processor to another, and received from one processor to another. At the end of each checkpoint, the crcs are compared. If they do not match, there was an error. The crcs may be cleared and restarted at each checkpoint. In the preferred embodiment, the basic functionality is to calculate a CRC of all packet data that has been successfully transmitted across a given link. This CRC is done on both ends of the link, thereby allowing an independent check on all data believed to have been correctly transmitted. Preferably, all links have this CRC coverage, and the CRC used in this link level check is different from that used in the packet transfer protocol. This independent check, if successfully passed, virtually eliminates the possibility that any data errors were missed during the previous transfer period.

Advances in CRC Prevention: Screening and Surveillance.

Science.gov (United States)

Dekker, Evelien; Rex, Douglas K

2018-05-01

Colorectal cancer (CRC) is among the most commonly diagnosed cancers and causes of death from cancer across the world. CRC can, however, be detected in asymptomatic patients at a curable stage, and several studies have shown lower mortality among patients who undergo screening compared with those who do not. Using colonoscopy in CRC screening also results in the detection of precancerous polyps that can be directly removed during the procedure, thereby reducing the incidence of cancer. In the past decade, convincing evidence has appeared that the effectiveness of colonoscopy as CRC prevention tool is associated with the quality of the procedure. This review aims to provide an up-to-date overview of recent efforts to improve colonoscopy effectiveness by enhancing detection and improving the completeness and safety of resection of colorectal lesions. Copyright © 2018 AGA Institute. Published by Elsevier Inc. All rights reserved.

High Rab27A expression indicates favorable prognosis in CRC.

Science.gov (United States)

Shi, Chuanbing; Yang, Xiaojun; Ni, Yijiang; Hou, Ning; Xu, Li; Zhan, Feng; Zhu, Huijun; Xiong, Lin; Chen, Pingsheng

2015-06-13

Rab27A is a peculiar member in Rab family and has been suggested to play essential roles in the development of human cancers. However, the association between Rab27A expression and clinicopathological characteristics of colorectal cancer (CRC) has not been elucidated yet. One-step quantitative real-time polymerase chain reaction (qPCR) test with 18 fresh-frozen CRC samples and immunohistochemistry (IHC) analysis in 112 CRC cases were executed to evaluate the relationship between Rab27A expression and the clinicopathological features of CRC. Cox regression and Kaplan-Meier survival analyses were performed to identify the prognostic factors for 112 CRC patients. The results specified that the expression levels of Rab27A mRNA and protein were significantly higher in CRC tissues than that in matched non-cancerous tissues, in both qPCR test (p = 0.029) and IHC analysis (p = 0.020). The IHC data indicated that the Rab27A protein expression in CRC was statistically correlated with lymph node metastasis (p = 0.022) and TNM stage (p = 0.026). Cox multi-factor analysis and Kaplan-Meier method suggested Rab27A protein expression (p = 0.012) and tumor differentiation (p = 0.004) were significantly associated with the overall survival of CRC patients. The data indicated the differentiate expression of Rab27A in CRC tissues and matched non-cancerous tissues. Rab27A may be used as a valuable prognostic biomarker for CRC patients.

Advances in CRC prevention: screening and surveillance

NARCIS (Netherlands)

Dekker, Evelien; Rex, Douglas K.

2018-01-01

Colorectal cancer (CRC) is amongst the most commonly diagnosed cancers and causes of death from cancer across the world. CRC can, however, be detected in asymptomatic patients at a curable stage, and several studies have shown lower mortality among patients who undergo screening compared to those

Long noncoding RNA lnc-sox5 modulates CRC tumorigenesis by unbalancing tumor microenvironment.

Science.gov (United States)

Wu, Kaiming; Zhao, Zhenxian; Liu, Kuanzhi; Zhang, Jian; Li, Guanghua; Wang, Liang

2017-07-03

Long non-coding RNAs (LncRNAs) have been recently regarded as systemic regulators in multiple biologic processes including tumorigenesis. In this study, we observed the expression of lncRNA lnc-sox5 was significantly increased in colorectal cancer (CRC). Despite the CRC cell growth, cell cycle and cell apoptosis was not affected by lnc-sox5 knock-down, lnc-sox5 knock-down suppressed CRC cell migration and invasion. In addition, xenograft animal model suggested that lnc-sox5 knock-down significantly suppressed the CRC tumorigenesis. Our results also showed that the expression of indoleamine 2,3-dioxygenase 1 (IDO1) was significantly reduced by lnc-sox5 knock-down and therefore modulated the infiltration and cytotoxicity of CD3 + CD8 + T cells. Taken together, these results suggested that lnc-sox5 unbalances tumor microenvironment to regulate colorectal cancer progression.

Employee Handbook

Energy Technology Data Exchange (ETDEWEB)

Bello, Madelyn

2008-09-05

Welcome to Berkeley Lab. You are joining or are already a part of a laboratory with a sterling tradition of scientific achievement, including eleven Nobel Laureates and thirteen National Medal of Science winners. No matter what job you do, you make Berkeley Lab the outstanding organization that it is. Without your hard work and dedication, we could not achieve all that we have. We value you and thank you for choosing to be part of our community. This Employee Handbook is designed to help you navigate the Lab. With over 3,000 employees, an additional 3,000 guests visiting from countries around the world, a 200-acre campus and many policies and procedures, learning all the ins and outs may seem overwhelming, especially if you're a new employee. However, even if you have been here for a while, this Handbook should be a useful reference tool. It is meant to serve as a guide, highlighting and summarizing what you need to know and informing you where you can go for more detailed information. The general information provided in this Handbook serves only as a brief description of many of the Lab's policies. Policies, procedures and information are found in the Lab's Regulations and Procedures Manual (RPM), Summary Plan Descriptions, University of California policies, and provisions of Contract 31 between the Regents of the University and the U.S. Department of Energy. In addition, specific terms and conditions for represented employees are found in applicable collective bargaining agreements. Nothing in this Handbook is intended to supplant, change or conflict with the previously mentioned documents. In addition, the information in this Handbook does not constitute a contract or a promise of continued employment and may be changed at any time by the Lab. We believe employees are happier and more productive if they know what they can expect from their organization and what their organization expects from them. The Handbook will familiarize you with the

CRC handbook of radiobiology

International Nuclear Information System (INIS)

Prasad, K.N.

1984-01-01

The author presents Development of Radiobiology. A Review. Basic Cell Biology. Physics of Radiation Biology. Cellular Radiation Damage. Modifications of Cellular Radiation Damage. Repair of Radiation Damage. Molecular Radiation Biology. Radiation Syndromes and their Modifications. Radiation Damage of Skin and Mucous Membrane. Radiation Damage of Nervous Tissue. Radiation Damage of Reproductive Organs. Radiation Damage of Other Organ Systems. Radiation Immunology. Background, Medical and Commercial Sources. Radiation Injuries to Human Fetuses. Radiation-Induced Genetic Damage. Radiation Carcinogenesis: Tissue Culture Model. Radiation Carcinogenesis: Animal Model. Radiation Carcinogenesis: Human Model. Radiation Carcinogenesis: Secondary Neoplasms. After Therapy of Tumors. Other Late Effects: Aging, Cataract, Aplastic Anemia. Maximum Permissible Dose (MPD). Radiation Response of Human Tumor. Radioisotopes in Biology and Medicine

Polar Coding with CRC-Aided List Decoding

Science.gov (United States)

2015-08-01

TECHNICAL REPORT 2087 August 2015 Polar Coding with CRC-Aided List Decoding David Wasserman Approved...list decoding . RESULTS Our simulation results show that polar coding can produce results very similar to the FEC used in the Digital Video...standard. RECOMMENDATIONS In any application for which the DVB-S2 FEC is considered, polar coding with CRC-aided list decod - ing with N = 65536

Potential role of TRIM3 as a novel tumour suppressor in colorectal cancer (CRC) development.

Science.gov (United States)

Piao, Mei-Yu; Cao, Hai-Long; He, Na-Na; Xu, Meng-Que; Dong, Wen-Xiao; Wang, Wei-Qiang; Wang, Bang-Mao; Zhou, Bing

2016-01-01

Colorectal cancer (CRC) is the third leading cause of cancer-related mortality in the United States. Recent cancer genome-sequencing efforts and complementary functional studies have led to the identification of a collection of candidate 'driver' genes involved in CRC tumorigenesis. Tripartite motif (TRIM3) is recently identified as a tumour suppressor in glioblastoma but this tumour-suppressive function has not been investigated in CRC. In this study, we investigated the potential role of TRIM3 as a tumour suppressor in CRC development by manipulating the expression of TRIM3 in two authentic CRC cell lines, HCT116 and DLD1, followed by various functional assays, including cell proliferation, colony formation, scratch wound healing, soft agar, and invasion assays. Xenograft experiment was performed to examine in vivo tumour-suppressive properties of TRIM3. Small-interfering RNA (siRNA) mediated knockdown of TRIM3 conferred growth advantage in CRC cells. In contrast, overexpression of TRIM3 affected cell survival, cell migration, anchorage independent growth and invasive potential in CRC cells. In addition, TRIM3 was found to be down-regulated in human colon cancer tissues compared with matched normal colon tissues. Overexpression of TRIM3 significantly inhibited tumour growth in vivo using xenograft mouse models. Mechanistic investigation revealed that TRIM3 can regulate p53 protein level through its stabilisation. TRIM3 functions as a tumour suppressor in CRC progression. This tumour-suppressive function is exerted partially through regulation of p53 protein. Therefore, this protein may represent a novel therapeutic target for prevention or intervention of CRC.

CRC Credential Attainment by State Vocational Rehabilitation Counselors

Science.gov (United States)

Harpster, Anna M.; Byers, Katherine L.; Harris, LaKeisha L.

2011-01-01

This study examines 137 state vocational rehabilitation (VR) counselors' perceptions of the value of having the Certified Rehabilitation Counselor (CRC) credential. While almost 53% of this sample included persons who were certified, the majority who were not indicated that the two major reasons for not currently having this designation were: (a)…

Nanoelectronic device applications handbook

CERN Document Server

Morris, James E

2013-01-01

Nanoelectronic Device Applications Handbook gives a comprehensive snapshot of the state of the art in nanodevices for nanoelectronics applications. Combining breadth and depth, the book includes 68 chapters on topics that range from nano-scaled complementary metal-oxide-semiconductor (CMOS) devices through recent developments in nano capacitors and AlGaAs/GaAs devices. The contributors are world-renowned experts from academia and industry from around the globe. The handbook explores current research into potentially disruptive technologies for a post-CMOS world.These include: Nanoscale advance

NASA Systems Engineering Handbook

Science.gov (United States)

Hirshorn, Steven R.; Voss, Linda D.; Bromley, Linda K.

2017-01-01

The update of this handbook continues the methodology of the previous revision: a top-down compatibility with higher level Agency policy and a bottom-up infusion of guidance from the NASA practitioners in the field. This approach provides the opportunity to obtain best practices from across NASA and bridge the information to the established NASA systems engineering processes and to communicate principles of good practice as well as alternative approaches rather than specify a particular way to accomplish a task. The result embodied in this handbook is a top-level implementation approach on the practice of systems engineering unique to NASA. Material used for updating this handbook has been drawn from many sources, including NPRs, Center systems engineering handbooks and processes, other Agency best practices, and external systems engineering textbooks and guides. This handbook consists of six chapters: (1) an introduction, (2) a systems engineering fundamentals discussion, (3) the NASA program project life cycles, (4) systems engineering processes to get from a concept to a design, (5) systems engineering processes to get from a design to a final product, and (6) crosscutting management processes in systems engineering. The chapters are supplemented by appendices that provide outlines, examples, and further information to illustrate topics in the chapters. The handbook makes extensive use of boxes and figures to define, refine, illustrate, and extend concepts in the chapters.

Deletions at SLC18A1 increased the risk of CRC and lower SLC18A1 expression associated with poor CRC outcome.

Science.gov (United States)

Zhang, Dandan; Li, Zhenli; Xu, Xiaohong; Zhou, Dan; Tang, Shunli; Yin, Xiaoyang; Xu, Fangying; Li, Hui; Zhou, Yuan; Zhu, Tao; Deng, Hong; Zhang, Shuai; Huang, Qiong; Wang, Jing; Yin, Wei; Zhu, Yimin; Lai, Maode

2017-10-26

Copy number variations (CNVs) contribute to the development of colorectal cancer (CRC). We conducted a two-stage association study to identify CNV risk loci for CRC. We performed a gene-based rare CNV study on 694 sporadic CRC and 1641 controls using Illumina Human-OmniExpress-12v1.0 BeadChips, and further replicated in 934 CRC cases and 2680 controls for risk CNVs by using TaqMan Copy Number Assay. Tumor buddings, cancer cells in the center of primary tumor and normal intestinal epithelial cells were captured using laser capture microdissection (LCM) and were assayed using AffymetrixGeneChip® Human Genome U133 Plus 2.0 Array. In addition, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus data were assessed for the effects of risk CNVs. We found that germline deletions affecting the last six exons of SLC18A1 significantly associated with CRC with a combined P value of 6.4 × 10-5 by a two-stage analysis. Both in TCGA CRC RNA seq dataset and GDS4382, SLC18A1 was significantly down regulated in CRC tissues than in paired normal tissues (N = 32 and 17 pairs, P = 0.004 and 0.009, respectively). In LCM samples, similar observations were obtained that the expression levels of SLC18A1 in the tumor buddings, cancer cells in the center of primary tumor, and stroma of both tumor budding and cancer cells were lower than normal intestinal epithelial and stromal cells (fold change = 0.17-0.62, 0.12-0.57 and 0.37-0.68, respectively). In summary, the germline deletions at SLC18A1 contributed to the development of CRC. The role of SLC18A1 required further exploration. © The Author 2017. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Handbook of probability

CERN Document Server

Florescu, Ionut

2013-01-01

THE COMPLETE COLLECTION NECESSARY FOR A CONCRETE UNDERSTANDING OF PROBABILITY Written in a clear, accessible, and comprehensive manner, the Handbook of Probability presents the fundamentals of probability with an emphasis on the balance of theory, application, and methodology. Utilizing basic examples throughout, the handbook expertly transitions between concepts and practice to allow readers an inclusive introduction to the field of probability. The book provides a useful format with self-contained chapters, allowing the reader easy and quick reference. Each chapter includes an introductio

Mining, Validation, and Clinical Significance of Colorectal Cancer (CRC)-Associated lncRNAs.

Science.gov (United States)

Sun, Xiangwei; Hu, Yingying; Zhang, Liang; Hu, Changyuan; Guo, Gangqiang; Mao, Chenchen; Xu, Jianfeng; Ye, Sisi; Huang, Guanli; Xue, Xiangyang; Guo, Aizhen; Shen, Xian

2016-01-01

Colorectal cancer (CRC) is one of the deadliest tumours, but its pathogenesis remains unclear. The involvement of differentially expressed long non-coding RNAs (lncRNAs) in CRC tumorigenesis makes them suitable tumour biomarkers. Here, we screened 150 cases of CRC and 85 cases of paracancerous tissues in the GEO database for differentially expressed lncRNAs. The levels of lncRNA candidates in 84 CRC and paracancerous tissue samples were validated by qRT-PCR and their clinical significance was analyzed. We identified 15 lncRNAs with differential expression in CRC tumours; among them, AK098081 was significantly up-regulated, whereas AK025209, BC040303, BC037331, AK026659, and CR749831 were down-regulated in CRC. In a receiver operating characteristic curve analysis, the area under the curve for the six lncRNAs was 0.914. High expression of AK098081 and low expression of BC040303, CR749831, and BC037331 indicated poor CRC differentiation. CRC patients with lymph node metastasis had lower expression of BC037331. In addition, the group with high AK098081 expression presented significantly lower overall survival and disease-free survival rates than the low-expression group, confirming AK098081 as an independent risk factor for CRC patients. In conclusion, we have identified multiple CRC-associated lncRNAs from microarray expression profiles that can serve as novel biomarkers for the diagnosis and prognosis of CRC.

A Novel Least Significant Bit First Processing Parallel CRC Circuit

Directory of Open Access Journals (Sweden)

Xiujie Qu

2013-01-01

Full Text Available In HDLC serial communication protocol, CRC calculation can first process the most or least significant bit of data. Nowadays most CRC calculation is based on the most significant bit (MSB first processing. An algorithm of the least significant bit (LSB first processing parallel CRC is proposed in this paper. Based on the general expression of the least significant bit first processing serial CRC, using state equation method of linear system, we derive a recursive formula by the mathematical deduction. The recursive formula is applicable to any number of bits processed in parallel and any series of generator polynomial. According to the formula, we present the parallel circuit of CRC calculation and implement it with VHDL on FPGA. The results verify the accuracy and effectiveness of this method.

77 FR 15609 - Revocation of TSCA Section 4 Testing Requirements for Certain High Production Volume Chemical...

Science.gov (United States)

2012-03-16

... substitute language for your requested changes. iv. Describe any assumptions and provide any technical... boiling point listed for that chemical substance in the ``Handbook of Chemistry and Physics'' (Ref. 21...-0182). 21. CRC Handbook of Chemistry and Physics. 85th Edition. David R. Lide, ed., CRC Press. Boca...

Radioactivity Handbook

International Nuclear Information System (INIS)

Firestone, R.B.; Browne, E.

1985-01-01

The Radioactivity Handbook will be published in 1985. This handbook is intended primarily for applied users of nuclear data. It will contain recommended radiation data for all radioactive isotopes. Pages from the Radioactivity Handbook for A = 221 are shown as examples. These have been produced from the LBL Isotopes Project extended ENDSF data-base. The skeleton schemes have been manually updated from the Table of Isotopes and the tabular data are prepared using UNIX with a phototypesetter. Some of the features of the Radioactivity Handbook are discussed here

DOE handbook: Design considerations

International Nuclear Information System (INIS)

1999-04-01

The Design Considerations Handbook includes information and suggestions for the design of systems typical to nuclear facilities, information specific to various types of special facilities, and information useful to various design disciplines. The handbook is presented in two parts. Part 1, which addresses design considerations, includes two sections. The first addresses the design of systems typically used in nuclear facilities to control radiation or radioactive materials. Specifically, this part addresses the design of confinement systems and radiation protection and effluent monitoring systems. The second section of Part 1 addresses the design of special facilities (i.e., specific types of nonreactor nuclear facilities). The specific design considerations provided in this section were developed from review of DOE 6430.1A and are supplemented with specific suggestions and considerations from designers with experience designing and operating such facilities. Part 2 of the Design Considerations Handbook describes good practices and design principles that should be considered in specific design disciplines, such as mechanical systems and electrical systems. These good practices are based on specific experiences in the design of nuclear facilities by design engineers with related experience. This part of the Design Considerations Handbook contains five sections, each of which applies to a particular engineering discipline

DOE handbook: Design considerations

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-04-01

The Design Considerations Handbook includes information and suggestions for the design of systems typical to nuclear facilities, information specific to various types of special facilities, and information useful to various design disciplines. The handbook is presented in two parts. Part 1, which addresses design considerations, includes two sections. The first addresses the design of systems typically used in nuclear facilities to control radiation or radioactive materials. Specifically, this part addresses the design of confinement systems and radiation protection and effluent monitoring systems. The second section of Part 1 addresses the design of special facilities (i.e., specific types of nonreactor nuclear facilities). The specific design considerations provided in this section were developed from review of DOE 6430.1A and are supplemented with specific suggestions and considerations from designers with experience designing and operating such facilities. Part 2 of the Design Considerations Handbook describes good practices and design principles that should be considered in specific design disciplines, such as mechanical systems and electrical systems. These good practices are based on specific experiences in the design of nuclear facilities by design engineers with related experience. This part of the Design Considerations Handbook contains five sections, each of which applies to a particular engineering discipline.

Handbook of Qualitative Research. Second Edition.

Science.gov (United States)

Denzin, Norman K., Ed.; Lincoln, Yvonna S., Ed.

This handbook's second edition represents the state of the art for the theory and practice of qualitative inquiry. It features eight new topics, including autoethnography, critical race theory, applied ethnography, queer theory, and "testimonio"every chapter in the handbook has been thoroughly revised and updated. The book…

Handbook for Policymackers

DEFF Research Database (Denmark)

Jensen, Ulla Højmark

2016-01-01

The purpose of the handbook is to support policy makers / decision makers by enabling them to make informed decisions about funding for second chance education or the adoption of its methods into mainstream education. The Handbook makes policy recommendations and provides guidelines to structure...... a quality assurance system that evidences success factors of second chance education and the value of informal learning. The handbook draws on the results of the literature review, the development of the quality assurance system (SMS system), the Teachers Handbook and the Organisational Handbook...

Mechanical Design Handbook for Elastomers

Science.gov (United States)

Darlow, M.; Zorzi, E.

1986-01-01

Mechanical Design Handbook for Elastomers reviews state of art in elastomer-damper technology with particular emphasis on applications of highspeed rotor dampers. Self-contained reference but includes some theoretical discussion to help reader understand how and why dampers used for rotating machines. Handbook presents step-by-step procedure for design of elastomer dampers and detailed examples of actual elastomer damper applications.

DOE fundamentals handbook: Chemistry

International Nuclear Information System (INIS)

1993-01-01

The Chemistry Handbook was developed to assist nuclear facility operating contractors in providing operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of chemistry. The handbook includes information on the atomic structure of matter; chemical bonding; chemical equations; chemical interactions involved with corrosion processes; water chemistry control, including the principles of water treatment; the hazards of chemicals and gases, and basic gaseous diffusion processes. This information will provide personnel with a foundation for understanding the chemical properties of materials and the way these properties can impose limitations on the operation of equipment and systems

Fuel Handbook[Wood and other renewable fuels

Energy Technology Data Exchange (ETDEWEB)

Stroemberg, Birgitta [TPS Termiska Processer AB, Nykoeping (SE)] (ed.)

2006-03-15

This handbook on renewable fuels is intended for power and heat producers in Sweden. This fuel handbook provides, from a plant owner's perspective, a method to evaluate different fuels on the market. The fuel handbook concerns renewable fuels (but does not include household waste) that are available on the Swedish market today or fuels that have potential to be available within the next ten years. The handbook covers 26 different fuels. Analysis data, special properties, operating experiences and literature references are outlined for each fuel. [Special properties, operating experiences and literature references are not included in this English version] The handbook also contains: A proposed methodology for introduction of new fuels. A recommendation of analyses and tests to perform in order to reduce the risk of problems is presented. [The recommendation of analyses and tests is not included in the English version] A summary of relevant laws and taxes for energy production, with references to relevant documentation. [Only laws and taxes regarding EU are included] Theory and background to evaluate a fuel with respect to combustion, ash and corrosion properties and methods that can be used for such evaluations. Summary of standards, databases and handbooks on biomass fuels and other solid fuels, and links to web sites where further information about the fuels can be found. The appendices includes: A methodology for trial firing of fuels. Calculations procedures for, amongst others, heating value, flue gas composition, key number and free fall velocity [Free fall velocity is not included in the English version]. In addition, conversion routines between different units for a number of different applications are provided. Fuel analyses are presented in the appendix. (The report is a translation of parts of the report VARMEFORSK--911 published in 2005)

Toxic substances handbook

Science.gov (United States)

Junod, T. L.

1979-01-01

Handbook, published in conjunction with Toxic Substances Alert Program at NASA Lewis Research Center, profiles 187 toxic chemicals in their relatively pure states and include 27 known or suspected carcinogens.

Survivin -31 G/C polymorphism might contribute to colorectal cancer (CRC) risk: a meta-analysis.

Science.gov (United States)

Yao, Linhua; Hu, Yi; Deng, Zhongmin; Li, Jingjing

2015-01-01

Published data has shown inconsistent findings about the association of survivin -31 G/C polymorphism with the risk of colorectal cancer (CRC). This meta-analysis quantitatively assesses the results from published studies to provide a more precise estimate of the association between survivin -31 G/C polymorphism as a possible predictor of the risk of CRC. We conducted a literature search in the PubMed, Web of Science, and Cochrane Library databases. Stata 12 software was used to calculate the pooled odds ratios (ORs) with 95% confidence intervals (CIs) based on the available data from each article. Six studies including 1840 cases with CRC and 1804 controls were included in this study. Survivin -31 G/C polymorphism was associated with a significantly increased risk of CRC (OR = 1.78; 95% CI, 1.53-2.07; I(2) = 0%). In the race subgroup analysis, both Asians (OR = 1.72; 95% CI, 1.44-2.05; I(2) = 0%) and Caucasians (OR = 1.93; 95% CI, 1.46-2.55; I(2) = 0%) with survivin -31 G/C polymorphism had increased CRC risk. In the subgroup analysis according to site of CRC, survivin -31 G/C polymorphism was not associated with colon cancer risk (OR = 2.02; 95% CI, 0.79-5.22; I(2) = 82%). However, this polymorphism was significantly associated with rectum cancer risk (OR = 1.98; 95% CI, 1.42-2.74; I(2) = 0%). In the subgroup analysis by clinical stage, both early stage (I+II) and advanced stage (III+IV) were associated with survivin -31 G/C polymorphism (OR = 1.61; 95% CI, 1.20-2.16; I(2) = 0% and OR = 2.30; 95% CI, 1.70-3.13; I(2) = 0%, respectively). In the subgroup analysis by smoke status, both smokers and non-smokers with survivin -31 G/C polymorphism showed increased CRC risk (OR = 1.47; 95% CI, 1.01-2.13; I(2) = 60% and OR = 1.71; 95% CI, 1.28-2.30; I(2) = 0%, respectively). In the subgroup analysis by drink status, both drinkers and non-drinkers with survivin -31 G/C polymorphism showed increased CRC risk (OR = 1.58; 95% CI, 1.06-2.37; I(2) = 8% and OR = 1.61; 95% CI, 1

Springer Handbook of Acoustics

CERN Document Server

Rossing, Thomas D

2007-01-01

Acoustics, the science of sound, has developed into a broad interdisciplinary field encompassing the academic disciplines of physics, engineering, psychology, speech, audiology, music, architecture, physiology, neuroscience, and others. The Springer Handbook of Acoustics is an unparalleled modern handbook reflecting this richly interdisciplinary nature edited by one of the acknowledged masters in the field, Thomas Rossing. Researchers and students benefit from the comprehensive contents spanning: animal acoustics including infrasound and ultrasound, environmental noise control, music and human speech and singing, physiological and psychological acoustics, architectural acoustics, physical and engineering acoustics, signal processing, medical acoustics, and ocean acoustics. This handbook reviews the most important areas of acoustics, with emphasis on current research. The authors of the various chapters are all experts in their fields. Each chapter is richly illustrated with figures and tables. The latest rese...

29 CFR 37.88 - Who may contact CRC about a complaint?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true Who may contact CRC about a complaint? 37.88 Section 37.88... PROVISIONS OF THE WORKFORCE INVESTMENT ACT OF 1998 (WIA) Compliance Procedures § 37.88 Who may contact CRC... contact CRC for information about the complaint. The Director will determine what information, if any...

KRAS polymorphisms are associated with survival of CRC in Chinese population.

Science.gov (United States)

Dai, Qiong; Wei, Hui Lian; Huang, Juan; Zhou, Tie Jun; Chai, Li; Yang, Zhi-Hui

2016-04-01

rs12245, rs12587, rs9266, rs1137282, rs61764370, and rs712 of KRAS oncogene are characterized in the 3'UTR. The study highlights the important role of these polymorphisms playing in the susceptibility, oxaliplatin-based chemotherapy sensitivity, progression, and prognosis of CRC. Improved multiplex ligation detection reaction (iMLDR) technique is used for genotyping. An unconditional logistic regression model was used to estimate the association of certain polymorphism and CRC risk. The Kaplan-Meier method, log-rank test, and Cox regression model were used to evaluate the effects of polymorphisms on survival analysis. Results demonstrated that TT genotype and T allele of rs712 were associated with the increased risk of CRC; the patients with GG genotype and G allele of rs61764370 had a shorter survival and a higher risk of relapse or metastasis of CRC. Our studies supported the conclusions that rs61764370 and rs712 polymorphisms of the KRAS are functional and it may play an important role in the development of CRC and oxaliplatin-based chemotherapy efficiency and prognosis of CRC.

Handbook of metaheuristics

CERN Document Server

Potvin, Jean-Yves

2010-01-01

“… an excellent book if you want to learn about a number of individual metaheuristics." (U. Aickelin, Journal of the Operational Research Society, Issue 56, 2005, on the First Edition) The first edition of the Handbook of Metaheuristics was published in 2003 under the editorship of Fred Glover and Gary A. Kochenberger. Given the numerous developments observed in the field of metaheuristics in recent years, it appeared that the time was ripe for a second edition of the Handbook. When Glover and Kochenberger were unable to prepare this second edition, they suggested that Michel Gendreau and Jean-Yves Potvin should take over the editorship, and so this important new edition is now available. Through its 21 chapters, this second edition is designed to provide a broad coverage of the concepts, implementations and applications in this important field of optimization. Original contributors either revised or updated their work, or provided entirely new chapters. The Handbook now includes updated chapters on the b...

Semiconductors data handbook

CERN Document Server

Madelung, Otfried

2004-01-01

This volume Semiconductors: Data Handbook contains frequently used data from the corresponding larger Landolt-Börnstein handbooks in a low price book for the individual scientist working in the laboratory. The Handbook contain important information about a large number of semiconductors

DOE handbook: Tritium handling and safe storage

Energy Technology Data Exchange (ETDEWEB)

NONE

1999-03-01

The DOE Handbook was developed as an educational supplement and reference for operations and maintenance personnel. Most of the tritium publications are written from a radiological protection perspective. This handbook provides more extensive guidance and advice on the null range of tritium operations. This handbook can be used by personnel involved in the full range of tritium handling from receipt to ultimate disposal. Compliance issues are addressed at each stage of handling. This handbook can also be used as a reference for those individuals involved in real time determination of bounding doses resulting from inadvertent tritium releases. This handbook provides useful information for establishing processes and procedures for the receipt, storage, assay, handling, packaging, and shipping of tritium and tritiated wastes. It includes discussions and advice on compliance-based issues and adds insight to those areas that currently possess unclear DOE guidance.

DOE handbook: Tritium handling and safe storage

International Nuclear Information System (INIS)

1999-03-01

The DOE Handbook was developed as an educational supplement and reference for operations and maintenance personnel. Most of the tritium publications are written from a radiological protection perspective. This handbook provides more extensive guidance and advice on the null range of tritium operations. This handbook can be used by personnel involved in the full range of tritium handling from receipt to ultimate disposal. Compliance issues are addressed at each stage of handling. This handbook can also be used as a reference for those individuals involved in real time determination of bounding doses resulting from inadvertent tritium releases. This handbook provides useful information for establishing processes and procedures for the receipt, storage, assay, handling, packaging, and shipping of tritium and tritiated wastes. It includes discussions and advice on compliance-based issues and adds insight to those areas that currently possess unclear DOE guidance

Handbook of biomedical optics

CERN Document Server

Boas, David A

2011-01-01

Biomedical optics holds tremendous promise to deliver effective, safe, non- or minimally invasive diagnostics and targeted, customizable therapeutics. Handbook of Biomedical Optics provides an in-depth treatment of the field, including coverage of applications for biomedical research, diagnosis, and therapy. It introduces the theory and fundamentals of each subject, ensuring accessibility to a wide multidisciplinary readership. It also offers a view of the state of the art and discusses advantages and disadvantages of various techniques.Organized into six sections, this handbook: Contains intr

The digital media handbook

CERN Document Server

Dewdney, Andrew

2013-01-01

The new edition of The Digital Media Handbook presents an essential guide to the historical and theoretical development of digital media, emphasising cultural continuity alongside technological change, and highlighting the emergence of new forms of communication in contemporary networked culture.Andrew Dewdney and Peter Ride present detailed critical commentary and descriptive historical accounts, as well as a series of interviews from a range of digital media practitioners, including producers, developers, curators and artists.The Digital Media Handbook highlights key concerns of today's prac

Handbook on Decision Making

CERN Document Server

Jain, Lakhmi C

2010-01-01

The present "Volume 1: Techniques and Applications" of the "Handbook on Decision Making" presents a useful collection of AI techniques, as well as other complementary methodologies, that are useful for the design and development of intelligent decision support systems. Application examples of how these intelligent decision support systems can be utilized to help tackle a variety of real-world problems in different domains, such as business, management, manufacturing, transportation and food industries, and biomedicine, are presented. The handbook includes twenty condensed c

Rechargeable batteries applications handbook

CERN Document Server

1998-01-01

Represents the first widely available compendium of the information needed by those design professionals responsible for using rechargeable batteries. This handbook introduces the most common forms of rechargeable batteries, including their history, the basic chemistry that governs their operation, and common design approaches. The introduction also exposes reader to common battery design terms and concepts.Two sections of the handbook provide performance information on two principal types of rechargeable batteries commonly found in consumer and industrial products: sealed nickel-cad

Knowledge Service Engineering Handbook

CERN Document Server

Kantola, Jussi

2012-01-01

Covering the emerging field of knowledge service engineering, this groundbreaking handbook outlines how to acquire and utilize knowledge in the 21st century. Drawn on the expertise of the founding faculty member of the world's first university knowledge engineering service department, this book describes what knowledge services engineering means and how it is different from service engineering and service production. Presenting multiple cultural aspects including US, Finnish, and Korean, this handbook provides engineering, systemic, industry, and consumer use viewpoints to knowledge service sy

Detection of colorectal cancer (CRC by urinary volatile organic compound analysis.

Directory of Open Access Journals (Sweden)

Ramesh P Arasaradnam

Full Text Available Colorectal cancer (CRC is a leading cause of cancer related death in Europe and the USA. There is no universally accepted effective non-invasive screening test for CRC. Guaiac based faecal occult blood (gFOB testing has largely been superseded by Faecal Immunochemical testing (FIT, but sensitivity still remains poor. The uptake of population based FOBt testing in the UK is also low at around 50%. The detection of volatile organic compounds (VOCs signature(s for many cancer subtypes is receiving increasing interest using a variety of gas phase analytical instruments. One such example is FAIMS (Field Asymmetric Ion Mobility Spectrometer. FAIMS is able to identify Inflammatory Bowel disease (IBD patients by analysing shifts in VOCs patterns in both urine and faeces. This study extends this concept to determine whether CRC patients can be identified through non-invasive analysis of urine, using FAIMS. 133 patients were recruited; 83 CRC patients and 50 healthy controls. Urine was collected at the time of CRC diagnosis and headspace analysis undertaken using a FAIMS instrument (Owlstone, Lonestar, UK. Data was processed using Fisher Discriminant Analysis (FDA after feature extraction from the raw data. FAIMS analyses demonstrated that the VOC profiles of CRC patients were tightly clustered and could be distinguished from healthy controls. Sensitivity and specificity for CRC detection with FAIMS were 88% and 60% respectively. This study suggests that VOC signatures emanating from urine can be detected in patients with CRC using ion mobility spectroscopy technology (FAIMS with potential as a novel screening tool.

Detection of colorectal cancer (CRC) by urinary volatile organic compound analysis.

Science.gov (United States)

Arasaradnam, Ramesh P; McFarlane, Michael J; Ryan-Fisher, Courtenay; Westenbrink, Erik; Hodges, Phoebe; Hodges, Paula; Thomas, Matthew G; Chambers, Samantha; O'Connell, Nicola; Bailey, Catherine; Harmston, Christopher; Nwokolo, Chuka U; Bardhan, Karna D; Covington, James A

2014-01-01

Colorectal cancer (CRC) is a leading cause of cancer related death in Europe and the USA. There is no universally accepted effective non-invasive screening test for CRC. Guaiac based faecal occult blood (gFOB) testing has largely been superseded by Faecal Immunochemical testing (FIT), but sensitivity still remains poor. The uptake of population based FOBt testing in the UK is also low at around 50%. The detection of volatile organic compounds (VOCs) signature(s) for many cancer subtypes is receiving increasing interest using a variety of gas phase analytical instruments. One such example is FAIMS (Field Asymmetric Ion Mobility Spectrometer). FAIMS is able to identify Inflammatory Bowel disease (IBD) patients by analysing shifts in VOCs patterns in both urine and faeces. This study extends this concept to determine whether CRC patients can be identified through non-invasive analysis of urine, using FAIMS. 133 patients were recruited; 83 CRC patients and 50 healthy controls. Urine was collected at the time of CRC diagnosis and headspace analysis undertaken using a FAIMS instrument (Owlstone, Lonestar, UK). Data was processed using Fisher Discriminant Analysis (FDA) after feature extraction from the raw data. FAIMS analyses demonstrated that the VOC profiles of CRC patients were tightly clustered and could be distinguished from healthy controls. Sensitivity and specificity for CRC detection with FAIMS were 88% and 60% respectively. This study suggests that VOC signatures emanating from urine can be detected in patients with CRC using ion mobility spectroscopy technology (FAIMS) with potential as a novel screening tool.

Handbook of unmanned aerial vehicles

CERN Document Server

Vachtsevanos, George

2015-01-01

The Handbook of Unmanned Aerial Vehicles is a reference text for the academic and research communities, industry, manufacturers, users, practitioners, Federal Government, Federal and State Agencies, the private sector, as well as all organizations that are and will be using unmanned aircraft in a wide spectrum of applications. The Handbook covers all aspects of UAVs, from design to logistics and ethical issues. It is also targeting the young investigator, the future inventor and entrepreneur by providing an overview and detailed information of the state-of-the-art as well as useful new concepts that may lead to innovative research. The contents of the Handbook include material that addresses the needs and ‘know how’ of all of the above sectors targeting a very diverse audience. The Handbook offers a unique and comprehensive treatise of everything one needs to know about unmanned aircrafts, from conception to operation, from technologies to business activities, users, OEMs, reference sources, conferences, ...

Performance Analysis of CRC Codes for Systematic and Nonsystematic Polar Codes with List Decoding

Directory of Open Access Journals (Sweden)

Takumi Murata

2018-01-01

Full Text Available Successive cancellation list (SCL decoding of polar codes is an effective approach that can significantly outperform the original successive cancellation (SC decoding, provided that proper cyclic redundancy-check (CRC codes are employed at the stage of candidate selection. Previous studies on CRC-assisted polar codes mostly focus on improvement of the decoding algorithms as well as their implementation, and little attention has been paid to the CRC code structure itself. For the CRC-concatenated polar codes with CRC code as their outer code, the use of longer CRC code leads to reduction of information rate, whereas the use of shorter CRC code may reduce the error detection probability, thus degrading the frame error rate (FER performance. Therefore, CRC codes of proper length should be employed in order to optimize the FER performance for a given signal-to-noise ratio (SNR per information bit. In this paper, we investigate the effect of CRC codes on the FER performance of polar codes with list decoding in terms of the CRC code length as well as its generator polynomials. Both the original nonsystematic and systematic polar codes are considered, and we also demonstrate that different behaviors of CRC codes should be observed depending on whether the inner polar code is systematic or not.

Do recent epidemiologic observations impact who and how we should screen for CRC?

Science.gov (United States)

Bortniker, Ethan; Anderson, Joseph C

2015-03-01

Colorectal cancer (CRC) screening is recommended to begin at age 50 for those patients with no significant family history of CRC. However, even within this group of average-risk patients, there is data to suggest that there may be variation in CRC risk. These observations suggest that perhaps CRC screening should be tailored to target those patients at higher risk for earlier or more invasive screening as compared to those individuals at lower risk. The strategy of how to identify those higher-risk patients may not be straightforward. One method might be to use single risk factors such as smoking or elevated BMI as has been suggested in the recent American College of Gastroenterology CRC screening guidelines. Another paradigm involves the use of models which incorporate several risk factors to stratify patients by risk. This article will highlight recent large studies that examine recognized CRC risk factors as well as review recently developed CRC risk models. There will also be a discussion of the application of these factors and models in an effort to make CRC screening more efficient.

Mechanical engineer's handbook

CERN Document Server

Marghitu, Dan B

2001-01-01

The Mechanical Engineer's Handbook was developed and written specifically to fill a need for mechanical engineers and mechanical engineering students throughout the world. With over 1000 pages, 550 illustrations, and 26 tables the Mechanical Engineer's Handbook is very comprehensive, yet affordable, compact, and durable. The Handbook covers all major areas of mechanical engineering with succinct coverage of the definitions, formulas, examples, theory, proofs, and explanations of all principle subject areas. The Handbook is an essential, practical companion for all mechanic

Technical handbook on the National Arrangements for Incidents involving Radioactivity. NAIR technical handbook

International Nuclear Information System (INIS)

McColl, N.P.; Kruse, P.

2002-01-01

This Technical Handbook contains information for radiation specialists participating in the National Arrangements for Incidents involving Radioactivity (NAIR). Together with the NAIR Users Handbook 2000 edition, it updates and replaces the NAIR Handbook published in 1995. The Users Handbook was designed for those who might seek assistance through NAIR, principally the police or other emergency services. Both Handbooks are reproduced on the NRPB website (www.nrpb.org) and are available from NRPB

Handbook of optical design

CERN Document Server

Malacara-Hernández, Daniel

2013-01-01

Handbook of Optical Design, Third Edition covers the fundamental principles of geometric optics and their application to lens design in one volume. It incorporates classic aspects of lens design along with important modern methods, tools, and instruments, including contemporary astronomical telescopes, Gaussian beams, and computer lens design. Written by respected researchers, the book has been extensively classroom-tested and developed in their lens design courses. This well-illustrated handbook clearly and concisely explains the intricacies of optical system design and evaluation. It also di

Mucin Expression in Colorectal Cancer (CRC): Systematic Review and Meta-Analysis.

Science.gov (United States)

Niv, Yaron; Rokkas, Theodore

2018-05-18

A body of evidence has suggested that mucins play an important role in adhesion, invasion, and cancer metastasis. However, this evidence is scarce and sometimes confusing. We performed a systematic review and meta-analysis of available studies to better define the role of mucins in the behavior of colorectal cancer (CRC). Medical literature was searched through November 30, 2017, using suitable keywords. Pooled estimates, that is, odd ratios (ORs), were obtained using fixed or random-effects models, as appropriate. Heterogeneity between studies was evaluated with the Cochran Q test and I values, whereas the likelihood of publication bias was assessed by constructing funnel plots. Their symmetry was estimated by the Begg and Mazumdar adjusted rank correlation test and by the Egger regression test. A total of 2234 CRC patients were included in 12 studies, eligible for meta-analysis. There was a significant difference concerning total mucin expression between CRC patients and controls [pooled ORs (95% confidence interval)=8.156 (2.624-25.354), test for overall effect Z=3.627, PCRC, that is advanced stage versus localized disease [ORs (95% confidence interval)=2.724 (1.211-6.127), Z= 2.423, P=0.015], as opposed to MUC2 and MUC4. MUC1 is overexpressed in CRC tissue comparing with healthy mucosa, and may have a role in the neoplastic transformation and metastatic process. MUC2 has probably no role in carcinogenesis.

Sittig's handbook of pesticides and agricultural chemicals

National Research Council Canada - National Science Library

Greene, Stanley A; Pohanish, Richard P

2005-01-01

... Card Number: 2005005935 Library of Congress Cataloging-in-Publication Data Sittig's handbook of pesticides and agricultural chemicals / edited by Stanley A. Greene and Richard P. Pohanish. p. cm. Includes bibliographical references. ISBN 0-8155-1516-2 (alk. paper) 1. Fertilizers--Handbooks, manuals, etc. 2. Fertilizers--Environmental aspects--Ha...

Handbook of smoke control engineering

CERN Document Server

Klote, John H; Turnbull, Paul G; Kashef, Ahmed; Ferreira, Michael J

2012-01-01

The Handbook of Smoke Control Engineering extends the tradition of the comprehensive treatment of smoke control technology, including fundamental concepts, smoke control systems, and methods of analysis. The handbook provides information needed for the analysis of design fires, including considerations of sprinklers, shielded fires, and transient fuels. It is also extremely useful for practicing engineers, architects, code officials, researchers, and students. Following the success of Principles of Smoke Management in 2002, this new book incorporates the latest research and advances in smoke control practice. New topics in the handbook are: controls, fire and smoke control in transport tunnels, and full-scale fire testing. For those getting started with the computer models CONTAM and CFAST, there are simplified instructions with examples. This is the first smoke control book with climatic data so that users will have easy-to-use weather data specifically for smoke control design for locations in the U.S., Can...

Handbook of vacuum physics

CERN Document Server

1964-01-01

Handbook of Vacuum Physics, Volume 3: Technology is a handbook of vacuum physics, with emphasis on the properties of miscellaneous materials such as mica, oils, greases, waxes, and rubber. Accurate modern tables of physical constants, properties of materials, laboratory techniques, and properties of commercial pumps, gauges, and leak detectors are presented. This volume is comprised of 12 chapters and begins with a discussion on pump oils, divided into rotary pump oils and vapor pump oils. The next chapter deals with the properties and applications of greases, including outgassing and vapor pr

Handbook of divorce and relationship dissolution

CERN Document Server

Fine, Mark A

2013-01-01

This Handbook presents up-to-date scholarship on the causes and predictors, processes, and consequences of divorce and relationship dissolution. Featuring contributions from multiple disciplines, this Handbook reviews relationship termination, including variations depending on legal status, race/ethnicity, and sexual orientation. The Handbook focuses on the often-neglected processes involved as the relationship unfolds, such as infidelity, hurt, and remarriage. It also covers the legal and policy aspects, the demographics, and the historical aspects of divorce. Intended for researchers, practitioners, counselors, clinicians, and advanced students in psychology, sociology, family studies, communication, and nursing, the book serves as a text in courses on divorce, marriage and the family, and close relationships.

Handbook of nuclear data for safeguards

International Nuclear Information System (INIS)

Lammer, M.; Schwerer, O.

1991-06-01

This handbook contains nuclear data needed by safeguards users for their work. It was initiated by an IAEA working group, and the contents were defined by the relies to a questionnaire sent to safeguards specialists. This is a preliminary edition of the handbook for distribution to safeguards and nuclear data experts for review. The present edition of the handbook contains the following basic nuclear data: actinides: nuclear decay data, thermal neutron cross sections and resonance integrals, prompt neutron data, delayed neutron data; fission products: nuclear decay data, thermal neutron capture cross sections and resonance integrals; fission product yields. Also included are appendices that summarize the data requested by safeguards users, and that present a number of questions to them and to data experts on the data contained in this preliminary issue and about additional data for possible inclusion in future editions and updates of the handbook

Sodium technology handbook

International Nuclear Information System (INIS)

2005-09-01

This document was published as a textbook for the education and training of personnel working for operations and maintenances of sodium facilities including FBR plants and those engaged in R and D activities related to sodium technology. This handbook covers the following technical areas. Properties of sodium. Compatibilities of sodium with materials. Thermalhydraulics and structural integrity. Sodium systems and components. Sodium instrumentations. Sodium handling technology. Sodium related accident evaluation and countermeasures for FBRs. Operation, maintenance and repair technology of sodium facilities. Safety measures related to sodium. Laws, regulations and internal rules related to sodium. The plannings and discussions of the handbook were made in the Sodium Technology Education Committee organized in O-arai Engineering Center consisting of the representatives of the related departments including Tsuruga headquarters. Experts in various departments participated in writing individual technical subjects. (author)

The Fuel Handbook 2012; Braenslehandboken 2012

Energy Technology Data Exchange (ETDEWEB)

Stroemberg, Birgitta; Herstad Svaerd, Solvie

2012-04-15

This fuel handbook provides, from a plant owner's perspective, a method of evaluating different fuels on the market. The fuel handbook concerns renewable fuels (but not including household waste) that are available on the Swedish market today or which are judged to have the potential to be available within the next ten years. The handbook covers 31 different fuels. Analysis data, special properties, operating experience, recommendations, risks when using the fuels and literature references are outlined for each fuel. The handbook also contains 1. A proposed route to follow when one plans to introduce a new fuel. Those analyses and tests one should perform to reduce the risk of encountering problems. 2. A summary of relevant laws and taxes for energy production, with directions as to where relevant documentation can be found. 3. Theory and background to judge the fuel's combustion, ash and corrosion properties and different methods that can be used for such judgement. 4. Summary of standards, databases and handbooks for biomass fuels and other solid fuels, and details on where further information on the fuels can be found, with the help of links to different web sites. Included in the annexes are 1. A proposal for a standard procedure for test burning of fuel. 2. Calculations procedures for, amongst others, heating value, flue gas composition and key numbers. In addition, calculations routines for different units for a number of different applications are provided

The Fuel Handbook 2012; Braenslehandboken 2012

Energy Technology Data Exchange (ETDEWEB)

Stroemberg, Birgitta; Herstad Svaerd, Solvie

2012-04-15

This fuel handbook provides, from a plant owner's perspective, a method of evaluating different fuels on the market. The fuel handbook concerns renewable fuels (but not including household waste) that are available on the Swedish market today or which are judged to have the potential to be available within the next ten years. The handbook covers 31 different fuels. Analysis data, special properties, operating experience, recommendations, risks when using the fuels and literature references are outlined for each fuel. The handbook also contains 1. A proposed route to follow when one plans to introduce a new fuel. Those analyses and tests one should perform to reduce the risk of encountering problems. 2. A summary of relevant laws and taxes for energy production, with directions as to where relevant documentation can be found. 3. Theory and background to judge the fuel's combustion, ash and corrosion properties and different methods that can be used for such judgement. 4. Summary of standards, databases and handbooks for biomass fuels and other solid fuels, and details on where further information on the fuels can be found, with the help of links to different web sites. Included in the annexes are 1. A proposal for a standard procedure for test burning of fuel. 2. Calculations procedures for, amongst others, heating value, flue gas composition and key numbers. In addition, calculations routines for different units for a number of different applications are provided

12 CFR 617.7310 - What is the review process of the CRC?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What is the review process of the CRC? 617.7310... on Applications; Review of Credit Decisions § 617.7310 What is the review process of the CRC? (a) How will an applicant or borrower know when the CRC will consider the review request? The qualified lender...

The Pseudomonas aeruginosa catabolite repression control protein Crc is devoid of RNA binding activity.

Science.gov (United States)

Milojevic, Tetyana; Grishkovskaya, Irina; Sonnleitner, Elisabeth; Djinovic-Carugo, Kristina; Bläsi, Udo

2013-01-01

The Crc protein has been shown to mediate catabolite repression control in Pseudomonas, leading to a preferential assimilation of carbon sources. It has been suggested that Crc acts as a translational repressor of mRNAs, encoding functions involved in uptake and breakdown of different carbon sources. Moreover, the regulatory RNA CrcZ, the level of which is increased in the presence of less preferred carbon sources, was suggested to bind to and sequester Crc, resulting in a relief of catabolite repression. Here, we determined the crystal structure of Pseudomonas aeruginosa Crc, a member of apurinic/apyrimidinic (AP) endonuclease family, at 1.8 Å. Although Crc displays high sequence similarity with its orthologs, there are amino acid alterations in the area corresponding to the active site in AP proteins. Unlike typical AP endonuclease family proteins, Crc has a reduced overall positive charge and the conserved positively charged amino-acid residues of the DNA-binding surface of AP proteins are partially substituted by negatively charged, polar and hydrophobic residues. Crc protein purified to homogeneity from P. aeruginosa did neither display DNase activity, nor did it bind to previously identified RNA substrates. Rather, the RNA chaperone Hfq was identified as a contaminant in His-tagged Crc preparations purified by one step Ni-affinity chromatography from Escherichia coli, and was shown to account for the RNA binding activity observed with the His-Crc preparations. Taken together, these data challenge a role of Crc as a direct translational repressor in carbon catabolite repression in P. aeruginosa.

Gen IV Materials Handbook Functionalities and Operation (2B) Handbook Version 2.0

International Nuclear Information System (INIS)

Ren, Weiju

2011-01-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Gen IV Materials Handbook Functionalities and Operation (4A) Handbook Version 4.0

Energy Technology Data Exchange (ETDEWEB)

Ren, Weiju [ORNL

2013-09-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Gen IV Materials Handbook Functionalities and Operation (2B) Handbook Version 2.0

Energy Technology Data Exchange (ETDEWEB)

Ren, Weiju [ORNL

2011-08-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Whole Gene Capture Analysis of 15 CRC Susceptibility Genes in Suspected Lynch Syndrome Patients.

Science.gov (United States)

Jansen, Anne M L; Geilenkirchen, Marije A; van Wezel, Tom; Jagmohan-Changur, Shantie C; Ruano, Dina; van der Klift, Heleen M; van den Akker, Brendy E W M; Laros, Jeroen F J; van Galen, Michiel; Wagner, Anja; Letteboer, Tom G W; Gómez-García, Encarna B; Tops, Carli M J; Vasen, Hans F; Devilee, Peter; Hes, Frederik J; Morreau, Hans; Wijnen, Juul T

2016-01-01

Lynch Syndrome (LS) is caused by pathogenic germline variants in one of the mismatch repair (MMR) genes. However, up to 60% of MMR-deficient colorectal cancer cases are categorized as suspected Lynch Syndrome (sLS) because no pathogenic MMR germline variant can be identified, which leads to difficulties in clinical management. We therefore analyzed the genomic regions of 15 CRC susceptibility genes in leukocyte DNA of 34 unrelated sLS patients and 11 patients with MLH1 hypermethylated tumors with a clear family history. Using targeted next-generation sequencing, we analyzed the entire non-repetitive genomic sequence, including intronic and regulatory sequences, of 15 CRC susceptibility genes. In addition, tumor DNA from 28 sLS patients was analyzed for somatic MMR variants. Of 1979 germline variants found in the leukocyte DNA of 34 sLS patients, one was a pathogenic variant (MLH1 c.1667+1delG). Leukocyte DNA of 11 patients with MLH1 hypermethylated tumors was negative for pathogenic germline variants in the tested CRC susceptibility genes and for germline MLH1 hypermethylation. Somatic DNA analysis of 28 sLS tumors identified eight (29%) cases with two pathogenic somatic variants, one with a VUS predicted to pathogenic and LOH, and nine cases (32%) with one pathogenic somatic variant (n = 8) or one VUS predicted to be pathogenic (n = 1). This is the first study in sLS patients to include the entire genomic sequence of CRC susceptibility genes. An underlying somatic or germline MMR gene defect was identified in ten of 34 sLS patients (29%). In the remaining sLS patients, the underlying genetic defect explaining the MMRdeficiency in their tumors might be found outside the genomic regions harboring the MMR and other known CRC susceptibility genes.

CRC handbook of methods for oxygen radical research

National Research Council Canada - National Science Library

Greenwald, Robert A

1985-01-01

.... This volume is divided into five sections. Section I deals with preparative methodology for isolation and purification of the components of the oxy radical experimental systems used most frequently, including all the three forms of SOD...

The CRC 20 years: An overview of some of the major achievements and remaining challenges.

Science.gov (United States)

Doek, Jaap E

2009-11-01

On 20 November 1989, the General Assembly of the United Nations adopted the Convention on the Rights of the Child (CRC). It entered into force on 2 September 1990 and has by now been ratified by 193 States, making the most universally ratified human rights treaty. This overview will present and discuss the impact of this treaty both at the international and the national level, an overview which necessarily has to be limited to some of the developments as a result of the implementation of the CRC. The first part of this paper will be devoted to the impact the CRC had and still has on the setting and development of the international agenda for the promotion and protection of the rights and welfare of children. Special attention will given to developments, achievements, and remaining challenges at the international level with regard to protection of children in armed conflict; prevention and the protection of children from sexual exploitation; and from all forms of violence. This will include some information on the impact of these international developments and actions at the national level, for example, in the area of legislation. The second part will focus on the impact at the national level. Given the wide scope of the CRC this part will be limited to some of the General Measures of Implementation (law reform, national programmes, and independent monitoring) and the General Principles (non-discrimination, best interest, right to be heard) of the CRC. This will be based on reports of States on the implementation of the CRC submitted to the CRC Committee and the Concluding Observations of this Committee and on a number of studies. The conclusion will provide remarks on poverty as one of the major remaining challenges for the implementation of children's rights.

Regulatory analysis technical evaluation handbook. Final report

International Nuclear Information System (INIS)

1997-01-01

The purpose of this Handbook is to provide guidance to the regulatory analyst to promote preparation of quality regulatory analysis documents and to implement the policies of the Regulatory Analysis Guidelines of the US Nuclear Regulatory Commission (NUREG/BR-0058 Rev. 2). This Handbook expands upon policy concepts included in the NRC Guidelines and translates the six steps in preparing regulatory analyses into implementable methodologies for the analyst. It provides standardized methods of preparation and presentation of regulatory analyses, with the inclusion of input that will satisfy all backfit requirements and requirements of NRC's Committee to Review Generic Requirements. Information on the objectives of the safety goal evaluation process and potential data sources for preparing a safety goal evaluation is also included. Consistent application of the methods provided here will result in more directly comparable analyses, thus aiding decision-makers in evaluating and comparing various regulatory actions. The handbook is being issued in loose-leaf format to facilitate revisions. NRC intends to periodically revise the handbook as new and improved guidance, data, and methods become available

Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa.

Science.gov (United States)

Wei, Yong; Zhang, Heng; Gao, Zeng-Qiang; Xu, Jian-Hua; Liu, Quan-Sheng; Dong, Yu-Hui

2013-01-01

The global metabolic regulator catabolite repression control (Crc) has recently been found to modulate the susceptibility to antibiotics and virulence in the opportunistic pathogen Pseudomonas aeruginosa and been suggested as a nonlethal target for novel antimicrobials. In P. aeruginosa, Crc couples with the CA motifs from the small RNA CrcZ to form a post-transcriptional regulator system and is removed from the 5'-end of the target mRNAs. In this study, we first reported the crystal structure of Crc from P. aeruginosa refined to 2.20 Å. The structure showed that it consists of two halves with similar overall topology and there are 11 β strands surrounded by 13 helices, forming a four-layered α/β-sandwich. The circular dichroism spectroscopy revealed that it is thermostable in solution and shares similar characteristics to that in crystal. Comprehensive structural analysis and comparison with the homologies of Crc showed high similarity with several known nucleases and consequently may be classified into a member exodeoxyribonuclease III. However, it shows distinct substrate specificity (RNA as the preferred substrate) compared to these DNA endonucleases. Structural comparisons also revealed potential RNA recognition and binding region mainly consisting of five flexible loops. Our structure study provided the basis for the future application of Crc as a target to develop new antibiotics. Copyright © 2012 International Union of Biochemistry and Molecular Biology, Inc.

The New Design Handbook for School Food Service. Revised.

Science.gov (United States)

Silberberg, Susan Crowl

A handbook, created for both designers and users of food service facilities in schools, provides reference information and guidance for making sure schools can provide quality food service. The handbook's first six chapters include explanations on how to start a school food service design project; required space, including kitchen work flow and…

CTBT technical issues handbook

International Nuclear Information System (INIS)

Zucca, J.J.

1994-05-01

The purpose of this handbook is to give the nonspecialist in nuclear explosion physics and nuclear test monitoring an introduction to the topic as it pertains to a Comprehensive Test Ban Treaty (CTBT). The authors have tried to make the handbook visually oriented, with figures paired to short discussions. As such, the handbook may be read straight through or in sections. The handbook covers four main areas and ends with a glossary, which includes both scientific terms and acronyms likely to be encountered during CTBT negotiations. The following topics are covered: (1) Physics of nuclear explosion experiments. This is a description of basic nuclear physics and elementary nuclear weapon design. Also discussed are testing practices. (2) Other nuclear experiments. This section discusses experiments that produce small amounts of nuclear energy but differ from explosion experiments discussed in the first chapter. This includes the type of activities, such as laser fusion, that would continue after a CTBT is in force. (3) Monitoring tests in various environments. This section describes the different physical environments in which a test could be conducted (underground, in the atmosphere, in space, underwater, and in the laboratory); the sources of non-nuclear events (such as earthquakes and mining operations); and the opportunities for evasion. (4) On-site inspections. A CTBT is likely to include these inspections as an element of the verification provisions, in order to resolve the nature of ambiguous events. This chapter describes some technical considerations and technologies that are likely to be useful. (5) Selecting verification measures. This chapter discusses the uncertain nature of the evidence from monitoring systems and how compliance judgments could be made, taking the uncertainties into account. It also discusses how to allocate monitoring resources, given the likelihood of testing by various countries in various environments

A Handbook of Essential Mathematical Formulae

CERN Document Server

Davies, Alan

2005-01-01

Intended for students of mathematics as well as of engineering, physical science, economics, business studies, and computer science, this handbook contains vital information and formulas for algebra, geometry, calculus, numerical methods, and statistics. Comprehensive tables of standard derivatives and integrals, together with the tables of Laplace, Fourier, and Z transforms are included. A spiral binding that allows the handbook to lay flat for easy reference enhances the user-friendly design.

Crane handbook

CERN Document Server

Dickie, D E

1975-01-01

Crane Handbook offers extensive advice on how to properly handle a crane. The handbook highlights various safety requirements and rules. The aim of the book is to improve the readers' crane operating skills, which could eventually make the book a standard working guide for training operators. The handbook first reminds the readers that the machine should be carefully tested by a regulatory board before use. The text then notes that choosing the right crane for a particular job is vital and explains why this is the case. It then discusses how well-equipped and durable the crane should be. T

A Quality Improvement Initiative to Increase Colorectal Cancer (CRC) Screening: Collaboration between a Primary Care Clinic and Research Team.

Science.gov (United States)

Green, Beverly B; Fuller, Sharon; Anderson, Melissa L; Mahoney, Christine; Mendy, Peter; Powell, Susan L

2017-01-01

Multiple randomized controlled trials have demonstrated that mailed fecal testing programs are effective in increasing colorectal cancer screening participation. However, few healthcare organization in the US have Implemented such programs. Stakeholders from one clinic in an integrated healthcare system in Washington State initiated collaboration with researchers with expertise in CRC screening, aiming to increase screening rates at their clinic. Age-eligible individuals who were overdue for CRC screening and had previously completed a fecal test were randomized to receive mailed fecal immunochemical test kits (FIT) at the start of the project (Early) or 6 months later (Late). Outcomes included comparing FIT completion at 6 months by randomization group, and overall CRC screening rates at 12 months. We also assessed implementation facilitators and challenges. Overall 2,421 FIT tests were mailed at a cost of $10,739. At 6 months, FIT completion was significantly higher among the Early compared to the Late group (62% vs.47%, p CRC screening rate was 75.1% at baseline and 78.0% 12 months later. Key constructs associated with successful program implementation included strong stakeholder involvement, use of evidence-based strategies, simplicity, and low cost. Challenges included lack of a plan for maintaining the program. Collaboration between clinic stakeholders and researchers led to a successful project that rapidly increased CRC screening rates. However, institutional normalization of the program would be required to maintain it.

Colorectal cancer diagnosis in 2012: A new focus for CRC prevention--more serration, less inflammation

NARCIS (Netherlands)

East, James E.; Dekker, Evelien

2013-01-01

Knowledge of colorectal cancer (CRC) risks has been rebalanced in 2012. The 'serrated pathway' to CRC, exemplified by serrated polyposis syndrome, emphasizes the importance of serrated lesions. The dogma that patients with IBD are at high risk of CRC, however, might be overstated; optimizing CRC

Handbook of thin film technology

CERN Document Server

Frey, Hartmut

2015-01-01

“Handbook of Thin Film Technology” covers all aspects of coatings preparation, characterization and applications. Different deposition techniques based on vacuum and plasma processes are presented. Methods of surface and thin film analysis including coating thickness, structural, optical, electrical, mechanical and magnetic properties of films are detailed described. The several applications of thin coatings and a special chapter focusing on nanoparticle-based films can be found in this handbook. A complete reference for students and professionals interested in the science and technology of thin films.

Quantitative proteomic analysis of paired colorectal cancer and non-tumorigenic tissues reveals signature proteins and perturbed pathways involved in CRC progression and metastasis.

Science.gov (United States)

Sethi, Manveen K; Thaysen-Andersen, Morten; Kim, Hoguen; Park, Cheol Keun; Baker, Mark S; Packer, Nicolle H; Paik, Young-Ki; Hancock, William S; Fanayan, Susan

2015-08-03

Modern proteomics has proven instrumental in our understanding of the molecular deregulations associated with the development and progression of cancer. Herein, we profile membrane-enriched proteome of tumor and adjacent normal tissues from eight CRC patients using label-free nanoLC-MS/MS-based quantitative proteomics and advanced pathway analysis. Of the 948 identified proteins, 184 proteins were differentially expressed (P1.5) between the tumor and non-tumor tissue (69 up-regulated and 115 down-regulated in tumor tissues). The CRC tumor and non-tumor tissues clustered tightly in separate groups using hierarchical cluster analysis of the differentially expressed proteins, indicating a strong CRC-association of this proteome subset. Specifically, cancer associated proteins such as FN1, TNC, DEFA1, ITGB2, MLEC, CDH17, EZR and pathways including actin cytoskeleton and RhoGDI signaling were deregulated. Stage-specific proteome signatures were identified including up-regulated ribosomal proteins and down-regulated annexin proteins in early stage CRC. Finally, EGFR(+) CRC tissues showed an EGFR-dependent down-regulation of cell adhesion molecules, relative to EGFR(-) tissues. Taken together, this study provides a detailed map of the altered proteome and associated protein pathways in CRC, which enhances our mechanistic understanding of CRC biology and opens avenues for a knowledge-driven search for candidate CRC protein markers. Copyright © 2015 Elsevier B.V. All rights reserved.

CRC-cards to support development and maintenance of product configuration systems

DEFF Research Database (Denmark)

Haug, Anders; Hvam, Lars

2009-01-01

This article presents a new definition of special Class, Responsibility and Collaboration (CRC) cards to be used for the development and maintenance of Product Configuration Systems (PCSs). CRC cards were introduced as an informal and user-friendly technique for teaching object-oriented modelling...... and maintenance of PCSs. This procedure has since been applied in several configuration projects and further developed at the Centre for Product Modelling (CPM) at the Technical University of Denmark. However, the investigations of two companies that applies CRC cards to document the knowledge base of their PCSs...

Cross-regulation by CrcZ RNA controls anoxic biofilm formation in Pseudomonas aeruginosa

Science.gov (United States)

Pusic, Petra; Tata, Muralidhar; Wolfinger, Michael T.; Sonnleitner, Elisabeth; Häussler, Susanne; Bläsi, Udo

2016-12-01

Pseudomonas aeruginosa (PA) can thrive in anaerobic biofilms in the lungs of cystic fibrosis (CF) patients. Here, we show that CrcZ is the most abundant PA14 RNA bound to the global regulator Hfq in anoxic biofilms grown in cystic fibrosis sputum medium. Hfq was crucial for anoxic biofilm formation. This observation complied with an RNAseq based transcriptome analysis and follow up studies that implicated Hfq in regulation of a central step preceding denitrification. CrcZ is known to act as a decoy that sequesters Hfq during relief of carbon catabolite repression, which in turn alleviates Hfq-mediated translational repression of catabolic genes. We therefore inferred that CrcZ indirectly impacts on biofilm formation by competing for Hfq. This hypothesis was supported by the findings that over-production of CrcZ mirrored the biofilm phenotype of the hfq deletion mutant, and that deletion of the crcZ gene augmented biofilm formation. To our knowledge, this is the first example where competition for Hfq by CrcZ cross-regulates an Hfq-dependent physiological process unrelated to carbon metabolism.

DOE/EPRI Electricity Storage Handbook in Collaboration with NRECA.

Energy Technology Data Exchange (ETDEWEB)

Akhil, Abbas Ali [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Huff, Georgianne [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Currier, Aileen B. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Kaun, Benjamin C [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Rastler, Dan M. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Chen, Stella Bingqing [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Cotter, Andrew L. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Bradshaw, Dale T. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States); Gauntlett, William D. [Sandia National Laboratories (SNL-NM), Albuquerque, NM (United States)

2015-02-01

The Electricity Storage Handbook (Handbook) is a how - to guide for utility and rural cooperative engineers, planners, and decision makers to plan and implement energy storage projects. The Handbook also serves as an information resource for investors and venture capitalists, providing the latest developments in technologies and tools to guide their evaluation s of energy storage opportunities. It includes a comprehensive database of the cost of current storage systems in a wide variety of electric utility and customer services, along with interconnection schematics. A list of significant past and present energy storage projects is provided for a practical perspective . This Handbook, jointly sponsored by the U.S. Department of Energy and the Electric Power Research Institute in collaboration with the National Rural Electric Cooperative Association, is published in electronic form at www.sandia.gov/ess. This Handbook is best viewed online.

Expressions of IGF-1, ERK, GLUT4, IRS-1 in metabolic syndrome complicated with colorectal cancer and their associations with the clinical characteristics of CRC.

Science.gov (United States)

Hu, Jianxia; Liu, Xiaoyi; Chi, Jingwei; Che, Kui; Feng, Yan; Zhao, Shihua; Wang, Zhongchao; Wang, Yangang

2018-01-01

Epidemiological data have revealed that colorectal cancer (CRC) risk is increased in patients with Metabolic syndrome. To explore the expressions of IGF-1, ERK, GLUT4, IRS-1 in MS patients with CRC and their associations with the clinical characteristics of CRC. We investigated the expressions of IGF-1, ERK, GLUT4 and IRS-1 in greater omental adipose tissues of 168 MS patients with/without CRC, 85 CRC patients without MS and 98 healthy controls by RT-PCR, and analyzed the relationships between their expressions and clinical characteristics of CRC. The expression levels of IGF-1 and ERK in MS patients with/without CRC were higher while the expression levels of GLUT4 were lower compared with CRC patients without MS and healthy controls (PCRC were higher while expression levels of GLUT4 were lower compared to MS patients without CRC (PCRC, including tumor size, distant metastasis and advanced stages (III/IV) (PCRC.

The CRC orthologue from Pisum sativum shows conserved functions in carpel morphogenesis and vascular development.

Science.gov (United States)

Fourquin, Chloé; Primo, Amparo; Martínez-Fernández, Irene; Huet-Trujillo, Estefanía; Ferrándiz, Cristina

2014-11-01

CRABS CLAW (CRC) is a member of the YABBY family of transcription factors involved in carpel morphogenesis, floral determinacy and nectary specification in arabidopsis. CRC orthologues have been functionally characterized across angiosperms, revealing additional roles in leaf vascular development and carpel identity specification in Poaceae. These studies support an ancestral role of CRC orthologues in carpel development, while roles in vascular development and nectary specification appear to be derived. This study aimed to expand research on CRC functional conservation to the legume family in order to better understand the evolutionary history of CRC orthologues in angiosperms. CRC orthologues from Pisum sativum and Medicago truncatula were identified. RNA in situ hybridization experiments determined the corresponding expression patterns throughout flower development. The phenotypic effects of reduced CRC activity were investigated in P. sativum using virus-induced gene silencing. CRC orthologues from P. sativum and M. truncatula showed similar expression patterns, mainly restricted to carpels and nectaries. However, these expression patterns differed from those of other core eudicots, most importantly in a lack of abaxial expression in the carpel and in atypical expression associated with the medial vein of the ovary. CRC downregulation in pea caused defects in carpel fusion and style/stigma development, both typically associated with CRC function in eudicots, but also affected vascular development in the carpel. The data support the conserved roles of CRC orthologues in carpel fusion, style/stigma development and nectary development. In addition, an intriguing new aspect of CRC function in legumes was the unexpected role in vascular development, which could be shared by other species from widely diverged clades within the angiosperms, suggesting that this role could be ancestral rather than derived, as so far generally accepted. © The Author 2014. Published by

Electrical transformer handbook

Energy Technology Data Exchange (ETDEWEB)

Hurst, R.W.; Horne, D. (eds.)

2005-07-01

This handbook is a valuable user guide intended for electrical engineering and maintenance personnel, electrical contractors and electrical engineering students. It provides current information on techniques and technologies that can help extend the life of transformers. It discusses transformer testing, monitoring, design, commissioning, retrofitting and other elements involved in keeping electrical transformers in safe and efficient operation. It demonstrates how a power transformer can be put to use and common problems faced by owners. In addition to covering control techniques, testing and maintenance procedures, this handbook covers the power transformer; control electrical power transformer; electrical power transformer; electrical theory transformer; used electrical transformer; down electrical step transformer; electrical manufacturer transformer; electrical picture transformer; electrical transformer work; electrical surplus transformer; current transformer; step down transformer; voltage transformer; step up transformer; isolation transformer; low voltage transformer; toroidal transformer; high voltage transformer; and control power transformer. The handbook includes articles from leading experts on overcurrent protection of transformers; ventilated dry-type transformers; metered load factors for low-voltage, and dry-type transformers in buildings. The maintenance of both dry-type or oil-filled transformers was discussed with reference to sealing, gaskets, oils, moisture and testing. The adoption of dynamic load practices was also discussed along with the reclamation or recycling of used lube oil, transformer dielectric fluids and aged solid insulation. A buyer's guide and directory of transformer manufacturers and suppliers was also included. refs., tabs., figs.

Handbook of Markov chain Monte Carlo

CERN Document Server

Brooks, Steve

2011-01-01

""Handbook of Markov Chain Monte Carlo"" brings together the major advances that have occurred in recent years while incorporating enough introductory material for new users of MCMC. Along with thorough coverage of the theoretical foundations and algorithmic and computational methodology, this comprehensive handbook includes substantial realistic case studies from a variety of disciplines. These case studies demonstrate the application of MCMC methods and serve as a series of templates for the construction, implementation, and choice of MCMC methodology.

Nuclear material accounting handbook

International Nuclear Information System (INIS)

2008-01-01

The handbook documents existing best practices and methods used to account for nuclear material and to prepare the required nuclear material accounting reports for submission to the IAEA. It provides a description of the processes and steps necessary for the establishment, implementation and maintenance of nuclear material accounting and control at the material balance area, facility and State levels, and defines the relevant terms. This handbook serves the needs of State personnel at various levels, including State authorities, facility operators and participants in training programmes. It can assist in developing and maintaining accounting systems which will support a State's ability to account for its nuclear material such that the IAEA can verify State declarations, and at the same time support the State's ability to ensure its nuclear security. In addition, the handbook is useful for IAEA staff, who is closely involved with nuclear material accounting. The handbook includes the steps and procedures a State needs to set up and maintain to provide assurance that it can account for its nuclear material and submit the prescribed nuclear material accounting reports defined in Section 1 and described in Sections 3 and 4 in terms of the relevant agreement(s), thereby enabling the IAEA to discharge its verification function as defined in Section 1 and described in Sections 3 and 4. The contents of the handbook are based on the model safeguards agreement and, where applicable, there will also be reference to the model additional protocol. As a State using The handbook consists of five sections. In Section 1, definitions or descriptions of terms used are provided in relation to where the IAEA applies safeguards or, for that matter, accounting for and control of nuclear material in a State. The IAEA's approach in applying safeguards in a State is also defined and briefly described, with special emphasis on verification. In Section 2, the obligations of the State

Experience with S-1 in older Caucasian patients with metastatic colorectal cancer (mCRC)

DEFF Research Database (Denmark)

Winther, Stine Braendegaard; Zubcevic, Kanita; Qvortrup, Camilla

2016-01-01

BACKGROUND: An aging population will increase the number of older patients with metastatic colorectal cancer (mCRC). However, there is limited knowledge about treatment in older patients as they are under-represented in clinical trials. The oral fluoropyrimidine S-1 is associated with a lower rate...... of adverse events than capecitabine and may therefore be a suitable drug for elderly. However, data on the use of S-1 in Caucasian mCRC patients are lacking/scarce. MATERIAL AND METHODS: In the present study we evaluated safety and the efficacy of S-1 alone or in combination with oxaliplatin (SOx......) or irinotecan (IRIS) in older mCRC patients. Patients who received at least one cycle of S-1 (first-line therapy), SOx (mainly first-line therapy) or IRIS (second-line therapy) were included. RESULTS: From June 2012 to December 2014, 71 older patients received ≥1 cycle of either S-1 (n = 9), SOx (n = 44...

Observations on Polar Coding with CRC-Aided List Decoding

Science.gov (United States)

2016-09-01

TECHNICAL REPORT 3041 September 2016 Observations on Polar Coding with CRC-Aided List Decoding David Wasserman Approved for public release. SSC...described in [2, 3]. In FY15 and FY16 we used cyclic redundancy check (CRC)-aided polar list decoding [4]. Section 2 describes the basics of polar coding ...and gives details of the encoders and decoders we used. In the course of our research, we performed simulations of polar codes in hundreds of cases

Co-expression analysis identifies CRC and AP1 the regulator of Arabidopsis fatty acid biosynthesis.

Science.gov (United States)

Han, Xinxin; Yin, Linlin; Xue, Hongwei

2012-07-01

Fatty acids (FAs) play crucial rules in signal transduction and plant development, however, the regulation of FA metabolism is still poorly understood. To study the relevant regulatory network, fifty-eight FA biosynthesis genes including de novo synthases, desaturases and elongases were selected as "guide genes" to construct the co-expression network. Calculation of the correlation between all Arabidopsis thaliana (L.) genes with each guide gene by Arabidopsis co-expression dating mining tools (ACT) identifies 797 candidate FA-correlated genes. Gene ontology (GO) analysis of these co-expressed genes showed they are tightly correlated to photosynthesis and carbohydrate metabolism, and function in many processes. Interestingly, 63 transcription factors (TFs) were identified as candidate FA biosynthesis regulators and 8 TF families are enriched. Two TF genes, CRC and AP1, both correlating with 8 FA guide genes, were further characterized. Analyses of the ap1 and crc mutant showed the altered total FA composition of mature seeds. The contents of palmitoleic acid, stearic acid, arachidic acid and eicosadienoic acid are decreased, whereas that of oleic acid is increased in ap1 and crc seeds, which is consistent with the qRT-PCR analysis revealing the suppressed expression of the corresponding guide genes. In addition, yeast one-hybrid analysis and electrophoretic mobility shift assay (EMSA) revealed that CRC can bind to the promoter regions of KCS7 and KCS15, indicating that CRC may directly regulate FA biosynthesis. © 2012 Institute of Botany, Chinese Academy of Sciences.

Disease severity does not affect the interval between IBD diagnosis and the development of CRC: results from two large, Dutch case series.

Science.gov (United States)

Mooiweer, Erik; Baars, Judith E; Lutgens, Maurice W M D; Vleggaar, Frank; van Oijen, Martijn; Siersema, Peter D; Kuipers, Ernst J; van der Woude, C Janneke; Oldenburg, Bas

2012-05-01

The increased risk of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD) is well established. The incidence of IBD-related CRC however, differs markedly between cohorts from referral centers and population-based studies. In the present study we aimed to identify characteristics potentially explaining these differences in two cohorts of patients with IBD-related CRC. PALGA, a nationwide pathology network and registry in The Netherlands, was used to search for patients with IBD-associated CRC between 1990 and 2006. Patients from 7 referral hospitals and 78 general hospitals were included. Demographic and disease specific parameters were collected retrospectively using patient charts. A total of 281 patients with IBD-associated CRC were identified. Patients from referral hospitals had a lower median age at IBD diagnosis (26 years vs. 28 years (p=0.02)), while having more IBD-relapses before CRC diagnosis than patients from general hospitals (3.8 vs. 1.5 (pCRC was diagnosed at a younger age (47 years vs. 51 years (p=0.01)). However, the median interval between IBD diagnosis and diagnosis of CRC was similar in both cohorts (19 years in referral hospitals vs. 17 years in general hospitals (p=0.13)). IBD patients diagnosed with CRC treated in referral hospitals in The Netherlands are younger at both the diagnosis of IBD and CRC than IBD patients with CRC treated in general hospitals. Although patients from referral centers appeared to have a more severe course of IBD, the interval between IBD and CRC diagnosis was similar. Copyright © 2011 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

12 CFR 617.7305 - What is a CRC and who are the members?

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 6 2010-01-01 2010-01-01 false What is a CRC and who are the members? 617.7305... on Applications; Review of Credit Decisions § 617.7305 What is a CRC and who are the members? The... decisions made by a qualified lender. The CRC may only review adverse credit decisions at the request of the...

Nuclear criticality safety handbook. Version 2

International Nuclear Information System (INIS)

1999-03-01

The Nuclear Criticality Safety Handbook, Version 2 essentially includes the description of the Supplement Report to the Nuclear Criticality Safety Handbook, released in 1995, into the first version of Nuclear Criticality Safety Handbook, published in 1988. The following two points are new: (1) exemplifying safety margins related to modelled dissolution and extraction processes, (2) describing evaluation methods and alarm system for criticality accidents. Revision is made based on previous studies for the chapter that treats modelling the fuel system: e.g., the fuel grain size that the system can be regarded as homogeneous, non-uniformity effect of fuel solution, and burnup credit. This revision solves the inconsistencies found in the first version between the evaluation of errors found in JACS code system and criticality condition data that were calculated based on the evaluation. (author)

3 GeV Injector Design Handbook

Energy Technology Data Exchange (ETDEWEB)

Wiedemann, H.; /SLAC, SSRL

2009-12-16

This Design Handbook is intended to be the main reference book for the specifications of the 3 GeV SPEAR booster synchrotron project. It is intended to be a consistent description of the project including design criteria, key technical specifications as well as current design approaches. Since a project is not complete till it's complete changes and modifications of early conceptual designs must be expected during the duration of the construction. Therefore, this Design Handbook is issued as a loose leaf binder so that individual sections can be replaced as needed. Each page will be dated to ease identification with respect to latest revisions. At the end of the project this Design Handbook will have become the 'as built' reference book of the injector for operations and maintenance personnel.

Handbook for Planning and Conducting Charrettes for High-Performance Projects

Energy Technology Data Exchange (ETDEWEB)

Lindsey, G.; Todd, J. A.; Hayter, S. J.

2003-08-01

The purpose of this handbook is to furnish guidance for planning and conducting a"high-performance building" charrette, sometimes called a"greening charrette." The handbook answers typical questions that will arise, such as"What is a charrette?""Why conduct a charrette?""What topics should we cover during the charrette?" and"Whom should we invite?" It also contains samples of agendas, invitation letters, and other commonly used charrette materials. This handbook also outlines the characteristics of a good charrette facilitator. It gives suggestions for the types of experts to invite to the event to motivate participants and answer their questions. The handbook includes sample presentations that can be used by these experts to ensure they address the required technical content. It suggests the types of participants, including technical, political, and community representatives, to invite to the charrette. It offers advice for forming effective breakout groups to ensure that a broad range of complementary expertise is represented in each group. We have also included guidance on how best to include key decision makers and stakeholders who are able to attend only portions of the event.

Biofuel technology handbook. 2. ed.

Energy Technology Data Exchange (ETDEWEB)

Rutz, Dominik; Janssen, Rainer

2008-01-15

This comprehensive handbook was created in order to promote the production and use of biofuels and to inform politicians, decision makers, biofuel traders and all other relevant stakeholders about the state-of-the-art of biofuels and relevant technologies. The large variety of feedstock types and different conversion technologies are described. Explanations about the most promising bio fuels provide a basis to discuss about the manifold issues of biofuels. The impartial information in this handbook further contributes to diminish existing barriers for the broad use of biofuels. Emphasis of this handbook is on first generation biofuels: bio ethanol, Biodiesel, pure plant oil, and bio methane. It also includes second generation biofuels such as BTL-fuels and bio ethanol from lingo-cellulose as well as bio hydrogen. The whole life cycle of bio fuels is assessed under technical, economical, ecological, and social aspect. Characteristics and applications of bio fuels for transport purposes are demonstrated and evaluated. This is completed by an assessment about the most recent studies on biofuel energy balances. This handbook describes the current discussion about green house gas (GHG) balances and sustainability aspects. GHG calculation methods are presented and potential impacts of biofuel production characterized: deforestation of rainforests and wetlands, loss of biodiversity, water pollution, human health, child labour, and labour conditions.

Energy manager's handbook

Energy Technology Data Exchange (ETDEWEB)

Payne, G A

1977-01-01

The handbook provides sufficient guidance on the principles involved for readers to tailor a program to meet their own requirement. The following chapters are included: Energy Conservation; Management of Energy; Delivery, Storage, and Handling of Fuels; Boilers; Furnaces; Heat Distribution and Utilization; Industrial Space Heating; Electricity; Services; and Road Transport. (MCW)

Loudspeaker handbook

CERN Document Server

Eargle, John

2003-01-01

The second edition of Loudspeaker Handbook follows the same general outlines as the highly successful first edition and has been augmented and updated in many areas of technology. Most notable are the developments in large-scale, programmable line arrays, distributed mode loudspeakers, and ultrasonic-based audio transduction. Additionally, the core chapters on low frequency systems, system concepts, and horn systems have been expanded to include both more analytical material and a richer array of examples. Much of the success of the first edition has been due to its accessibility both to loudspeaker engineers and to lay technicians working in the field - a point of view the author maintains in the present work. A full understanding of the underlying technology requires a fairly rigorous engineering background through the second year of professional study. At the same time, the generous use of graphs, with their intuitive thrust, will be useful to all readers. Loudspeaker Handbook, Second Edition continues to ...

Handbook on Windows and Energy

DEFF Research Database (Denmark)

Thomsen, Kirsten Engelund; Schultz, Jørgen Munthe; Svendsen, Sv Aa Højgaard

The handbook on windows and energy is a general description of windows with the main focus put on the energy performance. Common window products are described by commonly used nomenclature, description of frame and sash conctructions and description of commonly used glazing types.The energy...... transmission through windows is described in detail including radiation, convection and conduction as well as solar transmittance of window glazing. The most used terms related to characterization of window energy performance are defined and calculation methods according to international standards...... flow and detailed calculation of light and solar transmittance is given.Different measurement techniques for characterization of window heat loss coefficient and total solar energy transmittance is described and references to interantional standards are given.Finally, the handbook includes...

Diagnostic value of fecal tumor M2-pyruvate kinase for CRC screening: a systematic review and meta-analysis.

Science.gov (United States)

Li, Rui; Liu, Jianjun; Xue, Huiping; Huang, Gang

2012-10-15

The measurement of fecal tumor M2-pyruvate kinase (PKM2), overexpressed in tumor cells, has been proposed as a novel tool for detecting colorectal cancer (CRC). However, the sensitivity and specificity of this test varied among studies. The aim of this meta-analysis was to determine the diagnostic accuracy of fecal PKM2 for CRC and to evaluate its utility in the CRC screening. It was compared to guaiac fecal occult blood test (gFOBT) or immunological fecal occult blood test (iFOBT). Through comprehensive literature search, 10 studies met the inclusion criteria and were included. Summary estimates for sensitivity and specificity were calculated by using the bivariate random effect model. The hierarchical summary receiver operating characteristic curve was also undertaken. The overall sensitivity and specificity of fecal PKM2 for detecting CRC were 79% (95% CI = 75-83%) and 81% (95% CI = 73-87%), respectively. The summary positive predictive value and negative predictive value were 74% (95% CI = 56-87%) and 86% (95% CI = 79-91%), respectively. The pooled diagnostic odds ratio was 16 (95% CI = 10-26). In head-to-head comparison, the diagnostic odds ratio of PKM2 and gFOBT for CRC were 10.167 (95% CI = 5.992-17.250) and 6.557 (95% CI = 3.467-12.403), respectively. The diagnostic odds ratio of PKM2 and iFOBT for CRC were 9.542 (95% CI = 5.893-15.452) and 67.248 (95% CI = 16.194-279.26), respectively. The fecal PKM2 test was a diagnostic tool with moderate sensitivity and specificity for detecting CRC. Its diagnostic efficiency was similar to that of gFOBT. Because of its relatively low specificity and positive predict value, fecal PKM2 was not recommended used alone as a screening tool for CRC. Copyright © 2012 UICC.

Handbook of energy

CERN Document Server

Cleveland, Cutler J

2013-01-01

Handbook of Energy, Volume II: Chronologies, Top Ten Lists, and Word Clouds draws together a comprehensive account of the energy field from the prestigious and award-winning authors of the Encyclopedia of Energy (2004), The Dictionary of Energy, Expanded Edition (2009), and the Handbook of Energy, Volume I (2013). Handbook of Energy, Volume II takes the wealth of information about historical aspects of energy spread across many books, journals, websites, disciplines, ideologies, and user communities and synthesizes the information in one central repository. This book meets the needs of a di

Nuclear fuel cycle facility accident analysis handbook

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-03-01

The purpose of this Handbook is to provide guidance on how to calculate the characteristics of releases of radioactive materials and/or hazardous chemicals from nonreactor nuclear facilities. In addition, the Handbook provides guidance on how to calculate the consequences of those releases. There are four major chapters: Hazard Evaluation and Scenario Development; Source Term Determination; Transport Within Containment/Confinement; and Atmospheric Dispersion and Consequences Modeling. These chapters are supported by Appendices, including: a summary of chemical and nuclear information that contains descriptions of various fuel cycle facilities; details on how to calculate the characteristics of source terms for releases of hazardous chemicals; a comparison of NRC, EPA, and OSHA programs that address chemical safety; a summary of the performance of HEPA and other filters; and a discussion of uncertainties. Several sample problems are presented: a free-fall spill of powder, an explosion with radioactive release; a fire with radioactive release; filter failure; hydrogen fluoride release from a tankcar; a uranium hexafluoride cylinder rupture; a liquid spill in a vitrification plant; and a criticality incident. Finally, this Handbook includes a computer model, LPF No.1B, that is intended for use in calculating Leak Path Factors. A list of contributors to the Handbook is presented in Chapter 6. 39 figs., 35 tabs.

Nuclear fuel cycle facility accident analysis handbook

International Nuclear Information System (INIS)

1998-03-01

The purpose of this Handbook is to provide guidance on how to calculate the characteristics of releases of radioactive materials and/or hazardous chemicals from nonreactor nuclear facilities. In addition, the Handbook provides guidance on how to calculate the consequences of those releases. There are four major chapters: Hazard Evaluation and Scenario Development; Source Term Determination; Transport Within Containment/Confinement; and Atmospheric Dispersion and Consequences Modeling. These chapters are supported by Appendices, including: a summary of chemical and nuclear information that contains descriptions of various fuel cycle facilities; details on how to calculate the characteristics of source terms for releases of hazardous chemicals; a comparison of NRC, EPA, and OSHA programs that address chemical safety; a summary of the performance of HEPA and other filters; and a discussion of uncertainties. Several sample problems are presented: a free-fall spill of powder, an explosion with radioactive release; a fire with radioactive release; filter failure; hydrogen fluoride release from a tankcar; a uranium hexafluoride cylinder rupture; a liquid spill in a vitrification plant; and a criticality incident. Finally, this Handbook includes a computer model, LPF No.1B, that is intended for use in calculating Leak Path Factors. A list of contributors to the Handbook is presented in Chapter 6. 39 figs., 35 tabs

Parent Involvement Handbook.

Science.gov (United States)

Caplan, Arna

This handbook on parent involvement, designed to be used with preschool programs, was developed by the Jefferson County Public Schools in Lakewood, Colorado. Included are: (1) a general statement about parent involvement in an early childhood program, (2) a description of the Jefferson County Early Childhood Program, (3) a description of the…

29 CFR 37.38 - What information must grant applicants and recipients provide to CRC?

Science.gov (United States)

2010-07-01

... provide to CRC? 37.38 Section 37.38 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE... information must grant applicants and recipients provide to CRC? In addition to the information which must be collected, maintained, and, upon request, submitted to CRC under § 37.37: (a) Each grant applicant and...

Trustee Essentials: A Handbook for Wisconsin Public Library Trustees.

Science.gov (United States)

Wisconsin State Dept. of Public Instruction, Madison.

This handbook for Trustees of the Wisconsin Public Library describes in detail the tasks involved in being a library trustee. The handbook comprises a number of "Trustee Essentials" that cover the basic essential information needed by Trustees, as well as sources of additional information. Contents include: The Trustee Job Description;…

Embedded systems handbook networked embedded systems

CERN Document Server

Zurawski, Richard

2009-01-01

Considered a standard industry resource, the Embedded Systems Handbook provided researchers and technicians with the authoritative information needed to launch a wealth of diverse applications, including those in automotive electronics, industrial automated systems, and building automation and control. Now a new resource is required to report on current developments and provide a technical reference for those looking to move the field forward yet again. Divided into two volumes to accommodate this growth, the Embedded Systems Handbook, Second Edition presents a comprehensive view on this area

Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC.

Science.gov (United States)

Wang, Shuwei; Zhang, Weidong

2016-05-01

Interleukin (IL)-6 and the downstream Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway have previously been reported to be important in the development of colorectal cancer (CRC), and several studies have shown the relationship between the polymorphisms of related genes in this pathway with the risk of CRC. However, the findings of these related studies are inconsistent. Moreover, there has no systematic review and meta-analysis to evaluate the relationship between genetic variants in IL-6/JAK/STAT3 pathway and CRC susceptibility. Hence, we conducted a meta-analysis to explore the relationship between polymorphisms in IL-6/JAK/STAT3 pathway genes and CRC risk. Eighteen eligible studies with a total of 13,795 CRC cases and 18,043 controls were identified by searching PubMed, Web of Science, Embase, and the Cochrane Library databases for the period up to September 15, 2015. Odds ratios (ORs) and their 95 % confidence intervals (CIs) were used to calculate the strength of the association. Our results indicated that IL-6 genetic variants in allele additive model (OR = 1.05, 95 % CI = 1.00, 1.09) and JAK2 genetic variants (OR = 1.40, 95 % CI = 1.15, 1.65) in genotype recessive model were significantly associated with CRC risk. Moreover, the pooled data revealed that IL-6 rs1800795 polymorphism significantly increased the risk of CRC in allele additive model in Europe (OR = 1.07, 95 % CI = 1.01, 1.14). In conclusion, the present findings indicate that IL-6 and JAK2 genetic variants are associated with the increased risk of CRC while STAT3 genetic variants not. We need more well-designed clinical studies covering more countries and population to definitively establish the association between genetic variants in IL-6/JAK/STAT3 pathway and CRC susceptibility.

Peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and colorectal cancer (CRC) risk.

Science.gov (United States)

Wang, Wei; Shao, Yan; Tang, Shenhua; Cheng, Xianyong; Lian, Haifeng; Qin, Chengyong

2015-01-01

The association between the peroxisome proliferator-activated receptor-γ (PPARγ) Pro12Ala polymorphism and colorectal cancer (CRC) risk was inconclusive. We conducted a meta-analysis to evaluate the association between PPARγ Pro12Ala polymorphism and CRC risk. We searched Pubmed, EMBASE, and China National Knowledge Infrastructure databases. Data were extracted and pooled odds ratios (OR) with 95% confidence intervals (CI) were calculated. A total of 17 case-control studies with 12635 and 15803 controls were included in this meta-analysis. Overall, PPARγ Pro12Ala polymorphism was associated with CRC risk (OR = 0.84, 95% CI 0.75-0.94, P = 0.003, I(2) = 35%). In the subgroup analysis by ethnicity, a significant association was found among Caucasians (OR = 0.85, 95% CI 0.75-0.96, P = 0.007, I(2) = 38%) but not among Asians (OR = 0.76, 95% CI 0.51-1.12, P = 0.17, I(2) = 28%). In the subgroup analysis by CRC site, a significant association was found among colon cancer (OR = 0.81, 95% CI 0.66-0.98, P = 0.03, I(2) = 16%) but not among rectal cancer (OR = 0.83, 95% CI 0.57-1.21, P = 0.34, I(2) = 63%). The sensitivity analysis did not influence the result by omitting low-quality studies (OR = 0.76, 95% CI 0.63-0.93, P = 0.006, I(2) = 51%). In conclusion, this meta-analysis suggested that PPARγ Pro12Ala polymorphism was significant associated with CRC risk.

EURANOS. The Handbook Users Group (HUG)

DEFF Research Database (Denmark)

Nisbet, A.F.; Andersson, Kasper Grann; Carlé, B.

Three handbooks to assist in the management of contaminated food production systems, inhabited areas and drinking water supplies have been developed in conjunction with a wide range of stakeholders in Europe. These handbooks are living documents that will require updating from time to time.......eu-neris.net) to facilitate information exchange. Emergency centres in Member States not involved in the development of the handbooks were invited to take part in demonstration activities to establish whether the handbooks were useful for the purposes of contingency planning and accident management. Results from...... to remain state-of-the-art. To address this need, a handbook users’ group (HUG) was established in 2007 to provide a platform for maintaining the handbooks and to build a network of users for both the generic handbooks and any subsequently customised versions. A web site was set up (www...

PASHTO INSTRUCTOR'S HANDBOOK.

Science.gov (United States)

CHAVARRIA-AGUILAR, O.L.

THE MATERIALS IN THIS HANDBOOK CONSIST OF 64 PRONUNCIATION DRILLS FOR THE "PASHTO BASIC COURSE." THESE DRILLS ARE BASED ON A CONTRASTIVE ANALYSIS OF PASHTO AND ENGLISH PHONOLOGY AND ARE TO BE ADMINISTERED BY A NATIVE SPEAKER. SIXTY PASHTO ITEMS ARE INCLUDED IN EACH DRILL, 30 CONTAINING THE PARTICULAR SOUND BEING TAUGHT AND 30 CONTAINING…

Thermally Cross-Linked Anion Exchange Membranes from Solvent Processable Isoprene Containing Ionomers

Science.gov (United States)

2015-01-15

mm were obtained. Characterizations. 1H NMR spectroscopy was performed on a Bruker DPX-300 FT-NMR. Gel permeation chromatography (GPC) was performed...31, 7559−7561. (24) Greenley, R. Z. Q and e Values for Free Radical Copolymerizations of Vinyl Monomers and Telogens. In Polymer Handbook ; Brandrup, J...Diffusion at Infinite Dilution. In CRC Handbook of Chemistry and Physics, 81st ed.; CRC Press: Boca Raton, FL, 2001. (34) Schmidt-Rohr, K.; Chen, Q. Nat

Durability Testing of Additively Manufactured High Power Microwave Structures

Science.gov (United States)

2017-10-29

D. Hoffman, B. Singh and J. Thomas, Handbook of vacuum science and technology . San Diego, CA: Academic Press, 1998. [17] M. Cuneo, "The effect of...the higher He diffusion rate through rubber o-rings, its lower pumping speed within the cryopump and possibly saturation of the charcoal arrays...Third Edition, CRC Press (Boca Raton, FL, USA, 2016). [3] J. C. Whitaker, “Power Vacuum Tubes Handbook ”, Second Edition, CRC Press (New York, NY, USA

DOE/EPRI Electricity Storage Handbook in Collaboration with NRECA

Energy Technology Data Exchange (ETDEWEB)

Akhil, Abbas A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Energy Storage Technology and Systems; Huff, Georgianne [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Energy Storage Technology and Systems; Currier, Aileen B. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Energy Storage Technology and Systems; Hernandez, Jacquelynne [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States). Energy Storage Technology and Systems; Bender, Donald Arthur [Sandia National Lab. (SNL-CA), Livermore, CA (United States); Kaun, Benjamin C. [Electric Power Research Inst. (EPRI), Palo Alto, CA (United States); Rastler, Dan M. [Electric Power Research Inst. (EPRI), Palo Alto, CA (United States); Chen, Stella Bingqing [Electric Power Research Inst. (EPRI), Palo Alto, CA (United States); Cotter, Andrew L. [National Rural Electric Cooperative Association, Arlington, VA (United States); Bradshaw, Dale T. [National Rural Electric Cooperative Association, Arlington, VA (United States); Gauntlett, William D. [AECOM Technical Services, Inc., Albuquerque, NM (United States); Eyer, James [Clean Energy States Alliance, Montpelier, VT (United States); Olinsky-Paul, Todd [Clean Energy States Alliance, Montpelier, VT (United States); Ellison, Michelle [E& I Consulting, Oakland, CA (United States); Schoenung, Susan [Longitude 122 West, Inc., Menlo Park, CA (United States)

2016-09-01

The Electricity Storage Handbook (Handbook) is a how-to guide for utility and rural cooperative engineers, planners, and decision makers to plan and implement energy storage projects. The Handbook also serves as an information resource for investors and venture capitalists, providing the latest developments in technologies and tools to guide their evaluations of energy storage opportunities. It includes a comprehensive database of the cost of current storage systems in a wide variety of electric utility and customer services, along with interconnection schematics. A list of significant past and present energy storage projects is provided for a practical perspective. This Handbook, jointly sponsored by the U.S. Department of Energy and the Electric Power Research Institute in collaboration with the National Rural Electric Cooperative Association, is published in electronic form at www.sandia.gov/ess.

Handbook of systems toxicology

National Research Council Canada - National Science Library

Casciano, Daniel A; Sahu, Saura C

2011-01-01

"In the first handbook to comprehensively cover the emerging area of systems toxicology, the Handbook of Systems Toxicology provides an authoritative compilation of up-to-date developments presented...

National association of broadcasters engineering handbook NAB engineering handbook

CERN Document Server

Jones, Graham A; Osenkowsky, Thomas G; Williams, Edmund A

2013-01-01

The NAB Engineering Handbook provides detailed information on virtually every aspect of the broadcast chain, from news gathering, program production and postproduction through master control and distribution links to transmission, antennas, RF propagation, cable and satellite. Hot topics covered include HD Radio, HDTV, 2 GHz broadcast auxiliary services, EAS, workflow, metadata, digital asset management, advanced video and audio compression, audio and video over IP, and Internet broadcasting. A wide range of related topics that engineers and managers need to understand are also covered, includ

Two variants on T2DM susceptible gene HHEX are associated with CRC risk in a Chinese population.

Science.gov (United States)

Sun, Rui; Liu, Jian-Ping; Gao, Chang; Xiong, Ying-Ying; Li, Min; Wang, Ya-Ping; Su, Yan-Wei; Lin, Mei; Jiang, An-Li; Xiong, Ling-Fan; Xie, Yan; Feng, Jue-Ping

2016-05-17

Increasing amounts of evidence has demonstrated that T2DM (Type 2 Diabetes Mellitus) patients have increased susceptibility to CRC (colorectal cancer). As HHEX is a recognized susceptibility gene in T2DM, this work was focused on two SNPs in HHEX, rs1111875 and rs7923837, to study their association with CRC. T2DM patients without CRC (T2DM-only, n=300), T2DM with CRC (T2DM/CRC, n=135), cancer-free controls (Control, n=570), and CRC without T2DM (CRC-only, n=642) cases were enrolled. DNA samples were extracted from the peripheral blood leukocytes of the patients and sequenced by direct sequencing. The χ2 test was used to compare categorical data. We found that in T2DM patients, rs1111875 but not the rs7923837 in HHEX gene was associated with the occurrence of CRC (p= 0.006). for rs1111875, TC/CC patients had an increased risk of CRC (p=0.019, OR=1.592, 95%CI=1.046-2.423). Moreover, our results also indicated that the two variants of HEEX gene could be risk factors for CRC in general population, independent on T2DM (pCRC was observed in TC or TC/CC than CC individuals (pCRC risk was observed in AG, GG, and AG/GG than AA individuals (pCRC susceptibility. Risk effects and the functional impact of these polymorphisms need further validation.

Low-level-waste-treatment handbook

International Nuclear Information System (INIS)

Clinton, S.D.; Goeller, H.E.; Holladay, D.W.; Donaldson, T.L.

1982-01-01

The initial draft of the Low-Level Waste Treatment Handbook has been prepared and submitted to the DOE Low-Level Waste Management Program for review and comment. A revised draft is scheduled to be delivered to DOE Headquarters in December 1982. The Handbook is designed to be useful to all individuals and groups concerned with low-level wastes. It is one of several volumes that will ultimately comprise a Low-Level Waste Technology Handbook. The objective of the Low-Level Waste Treatment Handbook is to present an overview of current practices related to the segregation, classification, volume reduction, solidification, handling, packaging, and transportation of LLW for disposal in a shallow land burial facility. The Handbook is intended to serve as a guide to individuals interested in the treatment and handling of low-level radioactive waste. The Handbook will not explicitly tell the user how to design and operate LLW treatment facilities, but rather will identify (1) kinds of information required to evaluate the options, (2) methods that may be used to evaluate these options, and (3) limitations associated with the selection of the treatment options. The focus of the Handbook is providing guidance on how to do waste treatment for disposal by shallow land burial

Handbook of antenna technologies

CERN Document Server

Liu, Duixian; Nakano, Hisamatsu; Qing, Xianming; Zwick, Thomas

2016-01-01

The Handbook of Antenna Technologies aims to present the rapid development of antenna technologies, particularly in the past two decades, and also showcasing the newly developed technologies and the latest applications. The handbook will provide readers with the comprehensive updated reference information covering theory, modeling and optimization methods, design and measurement, new electromagnetic materials, and applications of antennas. The handbook will widely cover not only all key antenna design issues but also fundamentals, issues related to antennas (transmission, propagation, feeding structure, materials, fabrication, measurement, system, and unique design challenges in specific applications). This handbook will benefit the readers as a full and quick technical reference with a high-level historic review of technology, detailed technical descriptions and the latest practical applications.

Ewe (for Togo): Grammar Handbook. Peace Corps Language Handbook Series.

Science.gov (United States)

Kozelka, Paul R.

This handbook is composed of: (1) 20 grammar lessons; (2) an introduction to the handbook and to the Ewe language; (3) an appendix presenting the most important differences between Ewe and Mina, the lingua franca in the capital and in markets, offices, and work-sites throughout Togo; (4) answers to written summary exercises; (5) an Ewe-English…

FINODEX Handbook for Entrepreneurs

DEFF Research Database (Denmark)

The handbook provides short introductions to necessary knowledge for applicants in the two calls in October 2014 and June 2015 where they can present an idea for product development and apply for up to 10,000 Euro. Furthermore, the handbook is relevant for the next phase, where the selected approx....... 50 projects elaborate detailed technical and market plans. Last, the handbook provides links to further study and information about how to get help in later phases....

Energy Efficiency Governance: Handbook

Energy Technology Data Exchange (ETDEWEB)

NONE

2010-07-01

This handbook has been written to assist EE practitioners, government officials and stakeholders to establish effective EE governance structures for their country. The handbook provides readers with relevant information in an accessible format that will help develop comprehensive and effective governance mechanisms. For each of the specific topics dealt with (see Figure 1 in the Handbook), the IEA offers guidelines for addressing issues, or directs readers to examples of how such issues have been dealt with by specific countries.

Probiotics in colorectal cancer (CRC) with emphasis on mechanisms of action and current perspectives.

Science.gov (United States)

Kahouli, Imen; Tomaro-Duchesneau, Catherine; Prakash, Satya

2013-08-01

Colorectal cancer (CRC) is the third most common form of cancer. Diverse therapies such as chemotherapy, immunotherapy and radiation have shown beneficial effects, but are limited because of their safety and toxicity. Probiotic formulations have shown great promise in CRC as preventive and early stage therapeutics. This review highlights the importance of a balanced intestinal microbiota and summarizes the recent developments in probiotics for treating CRC. Specifically, this report describes evidence of the role of probiotics in modulating the microbiota, in improving the physico-chemical conditions of the gut and in reducing oxidative stress. It also discusses the mechanisms of probiotics in inhibiting tumour progression, in producing anticancer compounds and in modulating the host immune response. Even though some of these effects were observed in several clinical trials, when probiotic formulations were used as a supplement to CRC therapies, the application of probiotics as biotherapeutics against CRC still needs further investigation.

Oil economists' handbook 1984

Energy Technology Data Exchange (ETDEWEB)

Jenkins, G [ed.

1983-01-01

This handbook lists statistics on energy resources, production and consumption; petroleum refining, products, storage, quality and prices; shipping; pipelines; and energy companies. Conversion factors, a dictionary of terms, and a chronology of major events (1919-1938) are included. The data given runs up to 1982/83.

DOE handbook: Integrated safety management systems (ISMS) verification. Team leader's handbook

International Nuclear Information System (INIS)

1999-06-01

The primary purpose of this handbook is to provide guidance to the ISMS verification Team Leader and the verification team in conducting ISMS verifications. The handbook describes methods and approaches for the review of the ISMS documentation (Phase I) and ISMS implementation (Phase II) and provides information useful to the Team Leader in preparing the review plan, selecting and training the team, coordinating the conduct of the verification, and documenting the results. The process and techniques described are based on the results of several pilot ISMS verifications that have been conducted across the DOE complex. A secondary purpose of this handbook is to provide information useful in developing DOE personnel to conduct these reviews. Specifically, this handbook describes methods and approaches to: (1) Develop the scope of the Phase 1 and Phase 2 review processes to be consistent with the history, hazards, and complexity of the site, facility, or activity; (2) Develop procedures for the conduct of the Phase 1 review, validating that the ISMS documentation satisfies the DEAR clause as amplified in DOE Policies 450.4, 450.5, 450.6 and associated guidance and that DOE can effectively execute responsibilities as described in the Functions, Responsibilities, and Authorities Manual (FRAM); (3) Develop procedures for the conduct of the Phase 2 review, validating that the description approved by the Approval Authority, following or concurrent with the Phase 1 review, has been implemented; and (4) Describe a methodology by which the DOE ISMS verification teams will be advised, trained, and/or mentored to conduct subsequent ISMS verifications. The handbook provides proven methods and approaches for verifying that commitments related to the DEAR, the FRAM, and associated amplifying guidance are in place and implemented in nuclear and high risk facilities. This handbook also contains useful guidance to line managers when preparing for a review of ISMS for radiological

Nuclear Criticality Safety Handbook, Version 2. English translation

International Nuclear Information System (INIS)

2001-08-01

The Nuclear Criticality Safety Handbook, Version 2 essentially includes the description of the Supplement Report to the Nuclear Criticality Safety Handbook, released in 1995, into the first version of the Nuclear Criticality Safety Handbook, published in 1988. The following two points are new: (1) exemplifying safety margins related to modeled dissolution and extraction processes, (2) describing evaluation methods and alarm system for criticality accidents. Revision has been made based on previous studies for the chapter that treats modeling the fuel system: e.g., the fuel grain size that the system can be regarded as homogeneous, non-uniformity effect of fuel solution, an burnup credit. This revision has solved the inconsistencies found in the first version between the evaluation of errors found in JACS code system and the criticality condition data that were calculated based on the evaluation. This report is an English translation of the Nuclear Criticality Safety Handbook, Version 2, originally published in Japanese as JAERI 1340 in 1999. (author)

G9a stimulates CRC growth by inducing p53 Lys373 dimethylation-dependent activation of Plk1.

Science.gov (United States)

Zhang, Jie; Wang, Yafang; Shen, Yanyan; He, Pengxing; Ding, Jian; Chen, Yi

2018-01-01

Rationale: G9a is genetically deregulated in various tumor types and is important for cell proliferation; however, the mechanism underlying G9a-induced carcinogenesis, especially in colorectal cancer (CRC), is unclear. Here, we investigated if G9a exerts oncogenic effects in CRC by increasing polo-like kinase 1 (Plk1) expression. Thus, we further characterized the detailed molecular mechanisms. Methods: The role of Plk1 in G9a aberrant CRC was determined by performing different in vitro and in vivo assays, including assessment of cell growth by performing cell viability assay and assessment of signaling transduction profiles by performing immunoblotting, in the cases of pharmacological inhibition or short RNA interference-mediated suppression of G9a. Detailed molecular mechanisms underlying the effect of G9a on Plk1 expression were determined by performing point mutation analysis, chromatin immunoprecipitation analysis, and luciferase reporter assay. Correlation between G9a and Plk1 expression was determined by analyzing clinical samples of patients with CRC by performing immunohistochemistry. Results: Our study is the first to report a significant positive correlation between G9a and Plk1 levels in 89 clinical samples of patients with CRC. Moreover, G9a depletion decreased Plk1 expression and suppressed CRC cell growth both in vitro and in vivo , thus confirming the significant correlation between G9a and Plk1 levels. Further, we observed that G9a-induced Plk1 regulation depended on p53 inhibition. G9a dimethylated p53 at lysine 373, which in turn increased Plk1 expression and promoted CRC cell growth. Conclusions: These results indicate that G9a-induced and p53-dependent epigenetic programing stimulates the growth of colon cancer, which also suggests that G9a inhibitors that restore p53 activity are promising therapeutic agents for treating colon cancer, especially for CRC expressing wild-type p53.

ZEB1 Mediates Drug Resistance and EMT in p300-Deficient CRC.

Science.gov (United States)

Lazarova, Darina; Bordonaro, Michael

2017-01-01

We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed as therapeutic agents against CRC. We have previously discussed that resistance to butyrate likely contributes to colonic carcinogenesis, and we have demonstrated that butyrate resistance leads to cross-resistance to cancer therapeutic HDACis. Deregulated Wnt signaling is the major initiating event in most CRC cases. One mechanism whereby butyrate and other HDACis exert their anti-CRC effects is via Wnt signaling hyperactivation, which promotes CRC cell apoptosis. The histone acetylases (HATs) CBP and p300 are mediators of Wnt transcriptional activity, and play divergent roles in the downstream consequences of Wnt signaling. CBP-mediated Wnt signaling is associated with cell proliferation and stem cell maintenance; whereas, p300-mediated Wnt activity is associated with differentiation. We have found that CBP and p300 differentially affect the ability of butyrate to influence Wnt signaling, apoptosis, and proliferation. ZEB 1 is a Wnt signaling-targeted gene, whose product is a transcription factor expressed at the invasive front of carcinomas where it promotes malignant progression and EMT. ZEB1 is typically a transcriptional repressor; however, when associated with p300, ZEB1 enhances transcription. These changes in ZEB1 activity likely affect the cancer cell phenotype. ZEB1 has been shown to promote resistance to chemotherapeutic agents, and expression of ZEB1 is upregulated in butyrate-resistant CRC cells that lack p300 expression. Since the expression of ZEB1 correlates with poor outcomes in cancer, ZEB represents a relevant therapeutic target. Here we propose that targeting the signaling network established by ZEB1, Wnt signaling, and p300

Handbook on dynamics of jointed structures.

Energy Technology Data Exchange (ETDEWEB)

Ames, Nicoli M.; Lauffer, James P.; Jew, Michael D.; Segalman, Daniel Joseph; Gregory, Danny Lynn; Starr, Michael James; Resor, Brian Ray

2009-07-01

The problem of understanding and modeling the complicated physics underlying the action and response of the interfaces in typical structures under dynamic loading conditions has occupied researchers for many decades. This handbook presents an integrated approach to the goal of dynamic modeling of typical jointed structures, beginning with a mathematical assessment of experimental or simulation data, development of constitutive models to account for load histories to deformation, establishment of kinematic models coupling to the continuum models, and application of finite element analysis leading to dynamic structural simulation. In addition, formulations are discussed to mitigate the very short simulation time steps that appear to be required in numerical simulation for problems such as this. This handbook satisfies the commitment to DOE that Sandia will develop the technical content and write a Joints Handbook. The content will include: (1) Methods for characterizing the nonlinear stiffness and energy dissipation for typical joints used in mechanical systems and components. (2) The methodology will include practical guidance on experiments, and reduced order models that can be used to characterize joint behavior. (3) Examples for typical bolted and screw joints will be provided.

Faculty Handbook. Regis College.

Science.gov (United States)

Regis Coll., Weston, MA.

Regis College policies and procedures are described in this 1976 faculty handbook. Chapter 1 covers college organization and governance, including roles of academic officers and committees. Specific faculty data are presented in Chapter 2, such as definition of academic ranks and titles, recruitment and appointment, promotion, tenure, review,…

Girls Physical Education Handbook.

Science.gov (United States)

Fairfax County Schools, VA.

This handbook was designed to provide the student with basic information for various individual, dual, and team sports. The individual and dual sports which are discussed include archery, badminton, creative dance, fencing, golf, gymnastics, and games such as deck tennis, table tennis, horseshoes, and shuffledboard. Basketball, field hockey,…

Shallow-land-burial handbook

International Nuclear Information System (INIS)

Boegly, W.J. Jr.; Davis, E.C.

1981-01-01

The initial draft of the Shallow-Land Burial Handbook has been prepared and submitted to the DOE Low-Level Waste Management Program for review and comment. The Handbook informs the reader of the current way in which low-level wastes are being handled, outlines the legal and institutional problems that would be involved in developing and licensing such a facility, and describes in some detail the considerations and data needs for siting, designing, operating, and closing such a facility. The initial draft is not a Handbook that provides answers to all questions, nor insures that following the steps detailed in the Handbook guarantees that the facility will be licensed. It does illustrate the types of actions that must be considered and the types of information required to achieve successful operations

Environmental and Social Management System Implementation Handbook : Crop Production

OpenAIRE

International Finance Corporation

2014-01-01

This Handbook is intended to be a practical guide to help companies in the crop production industry develop and implement an environmental and social management system, which should help to improve overall operations. If a company has existing management systems for quality or health and safety, this Handbook will help to expand them to include environmental and social performance. Sectio...

NASA Risk Management Handbook. Version 1.0

Science.gov (United States)

Dezfuli, Homayoon; Benjamin, Allan; Everett, Christopher; Maggio, Gaspare; Stamatelatos, Michael; Youngblood, Robert; Guarro, Sergio; Rutledge, Peter; Sherrard, James; Smith, Curtis;

Java EE 7 handbook

CERN Document Server

Pilgrim, Peter A

2013-01-01

Java EE 7 Handbook is an example based tutorial with descriptions and explanations.""Java EE 7 Handbook"" is for the developer, designer, and architect aiming to get acquainted with the Java EE platform in its newest edition. This guide will enhance your knowledge about the Java EE 7 platform. Whether you are a long-term Java EE (J2EE) developer or an intermediate level engineer on the JVM with just Java SE behind you, this handbook is for you, the new contemporary Java EE 7 developer!

DOE Fundamentals Handbook: Mathematics, Volume 1

International Nuclear Information System (INIS)

1992-06-01

The Mathematics Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of mathematics and its application to facility operation. The handbook includes a review of introductory mathematics and the concepts and functional use of algebra, geometry, trigonometry, and calculus. Word problems, equations, calculations, and practical exercises that require the use of each of the mathematical concepts are also presented. This information will provide personnel with a foundation for understanding and performing basic mathematical calculations that are associated with various DOE nuclear facility operations

DOE Fundamentals Handbook: Mathematics, Volume 2

International Nuclear Information System (INIS)

1992-06-01

The Mathematics Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of mathematics and its application to facility operation. The handbook includes a review of introductory mathematics and the concepts and functional use of algebra, geometry, trigonometry, and calculus. Word problems, equations, calculations, and practical exercises that require the use of each of the mathematical concepts are also presented. This information will provide personnel with a foundation for understanding and performing basic mathematical calculations that are associated with various DOE nuclear facility operations

29 CFR 37.84 - What happens if CRC does not have jurisdiction over a complaint?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true What happens if CRC does not have jurisdiction over a complaint? 37.84 Section 37.84 Labor Office of the Secretary of Labor IMPLEMENTATION OF THE... Procedures § 37.84 What happens if CRC does not have jurisdiction over a complaint? If CRC does not have...

Springer handbook of ocean engineering

CERN Document Server

Xiros, Nikolaos

2016-01-01

The handbook is the definitive reference for the interdisciplinary field that is ocean engineering. It integrates the coverage of fundamental and applied material and encompasses a diverse spectrum of systems, concepts and operations in the maritime environment, as well as providing a comprehensive update on contemporary, leading-edge ocean technologies. Coverage includes but is not limited to; an overview of ocean science, ocean signals and instrumentation, coastal structures, developments in ocean energy technologies, and ocean vehicles and automation. The handbook will be of interest to practitioners in a range of offshore industries and naval establishments as well as academic researchers and graduate students in ocean, coastal, offshore, and marine engineering and naval architecture.

Handbook of Visual Display Technology

CERN Document Server

Cranton, Wayne; Fihn, Mark

2012-01-01

The Handbook of Visual Display Technology is a unique work offering a comprehensive description of the science, technology, economic and human interface factors associated with the displays industry. An invaluable compilation of information, the Handbook will serve as a single reference source with expert contributions from over 150 international display professionals and academic researchers. All classes of display device are covered including LCDs, reflective displays, flexible solutions and emissive devices such as OLEDs and plasma displays, with discussion of established principles, emergent technologies, and particular areas of application. The wide-ranging content also encompasses the fundamental science of light and vision, image manipulation, core materials and processing techniques, display driving and metrology.

A Poetry Handbook.

Science.gov (United States)

Oliver, Mary

Intended to impart the basic ways a poem is constructed, this concise handbook is a prose guide to writing poetry. The handbook talks about meter and rhyme, form and diction, sound and sense, iambs and trochees, couplets and sonnets, and how and why this should matter to any person writing or reading poetry. Interspersing history and analysis with…

Evaluating the impact of an educational intervention to increase CRC screening rates in the African American community: a preliminary study.

Science.gov (United States)

Philip, Errol J; DuHamel, Katherine; Jandorf, Lina

2010-10-01

Despite the acknowledged importance of colorectal cancer (CRC) screening and its proven prognostic benefit, African American men and women simultaneously possess the highest rates of CRC-related incidence and mortality (Swan et al. in Cancer 97(6):1528-1540, 2003) and lowest screening rates in the United States (Polite et al. in Med Clin N Am 89(4):771-793, 2005). Effective, targeted interventions that promote CRC screening for this community are therefore critical. The current study evaluated the impact of a print-based educational intervention on screening behavior and associated patient-based factors, including cancer-related knowledge, fatalism, worry, and decisional balance (pros-cons). One hundred and eighteen individuals (mean age = 56.08, SD = 5.58) who had not undergone screening were recruited from two health clinics in New York City. Each participant received educational print materials regarding the need for screening, the process of undergoing screening, and the benefits of regular CRC screening. One in four individuals had undergone post-intervention screening at a three-month follow-up. Whereas all participants reported a decrease in cancer-related worry (p benefits and barriers of screening may be critical in the decision to undergo CRC screening. Future interventions to increase CRC-screening rates for this community may be improved by focusing on these patient-based factors.

Association between hMLH1 hypermethylation and JC virus (JCV) infection in human colorectal cancer (CRC).

Science.gov (United States)

Vilkin, Alex; Niv, Yaron

2011-04-01

Incorporation of viral DNA may interfere with the normal sequence of human DNA bases on the genetic level or cause secondary epigenetic changes such as gene promoter methylation or histone acetylation. Colorectal cancer (CRC) is the second leading cause of cancer mortality in the USA. Chromosomal instability (CIN) was established as the key mechanism in cancer development. Later, it was found that CRC results not only from the progressive accumulation of genetic alterations but also from epigenetic changes. JC virus (JCV) is a candidate etiologic factor in sporadic CRC. It may act by stabilizing β-catenin, facilitating its entrance to the cell nucleus, initialing proliferation and cancer development. Diploid CRC cell lines transfected with JCV-containing plasmids developed CIN. This result provides direct experimental evidence for the ability of JCV T-Ag to induce CIN in the genome of colonic epithelial cells. The association of CRC hMLH1 methylation and tumor positivity for JCV was recently documented. JC virus T-Ag DNA sequences were found in 77% of CRCs and are associated with promoter methylation of multiple genes. hMLH1 was methylated in 25 out of 80 CRC patients positive for T-Ag (31%) in comparison with only one out of 11 T-Ag negative cases (9%). Thus, JCV can mediate both CIN and aberrant methylation in CRC. Like other viruses, chronic infection with JCV may induce CRC by different mechanisms which should be further investigated. Thus, gene promoter methylation induced by JCV may be an important process in CRC and the polyp-carcinoma sequence.

[Records of growth and development data in the child health handbook].

Science.gov (United States)

Abud, Simone Mourão; Gaíva, Maria Aparecida Munhoz

2015-06-01

The aim was to analyse the input of growth and development data in the Child Health Handbook. This is a cross-sectional study conducted in Cuiabá, Brazil, on August 13, 2011, with the application of a questionnaire and direct observation of 950 handbooks. We included children under one year of age who resided in Cuiabá, accompanied by their mothers or guardians who were in possession of the handbook. Data were analyzed by calculating the prevalence ratio (PR) and Chi-Square test, with a significance level set at 5%. The project was approved by the Ethics Committee under Opinion No. 882/2010. Of the analyzed handbooks, 95.4% of the development data and 79.6% of the data in the growth charts were incomplete or missing. The low rate of growth and development data input in the handbooks reveals the need to create awareness among the population, health care professionals and managers on the importance of handbooks, and the need to invest in training and the empowerment of professionals in relation to its proper use.

76 FR 60474 - Commercial Item Handbook

Science.gov (United States)

2011-09-29

... DEPARTMENT OF DEFENSE Defense Acquisition Regulations System Commercial Item Handbook AGENCY.... SUMMARY: DoD has updated its Commercial Item Handbook. The purpose of the Handbook is to help acquisition personnel develop sound business strategies for procuring commercial items. DoD is seeking industry input on...

A handbook of silicate rock analysis

International Nuclear Information System (INIS)

Potts, P.J.

1986-01-01

The topics covered in this handbook include the following: concepts in analytical chemistry; wet chemical and optical spectroscopy methods; X-ray and micro-beam methods; nuclear methods; pre-concentration techniques; and mass spectrometry

Communications technology handbook

CERN Document Server

Lewis, Geoff

2013-01-01

This is the first point of reference for the communications industries. It offers an introduction to a wide range of topics and concepts encountered in the field of communications technology. Whether you are looking for a simple explanation, or need to go into a subject in more depth, the Communications Technology Handbook provides all the information you need in one single volume.This second edition has been updated to include the latest technology including: Video on DemandWire-less Distribution systemsHigh spee

RGC32 induces epithelial-mesenchymal transition by activating the Smad/Sip1 signaling pathway in CRC.

Science.gov (United States)

Wang, Xiao-Yan; Li, Sheng-Nan; Zhu, Hui-Fang; Hu, Zhi-Yan; Zhong, Yan; Gu, Chuan-Sha; Chen, Shi-You; Liu, Teng-Fei; Li, Zu-Guo

2017-05-04

Response gene to complement 32 (RGC32) is a transcription factor that regulates the expression of multiple genes involved in cell growth, viability and tissue-specific differentiation. However, the role of RGC32 in tumorigenesis and tumor progression in colorectal cancer (CRC) has not been fully elucidated. Here, we showed that the expression of RGC32 was significantly up-regulated in human CRC tissues versus adjacent normal tissues. RGC32 expression was significantly correlated with invasive and aggressive characteristics of tumor cells, as well as poor survival of CRC patients. We also demonstrated that RGC32 overexpression promoted proliferation, migration and tumorigenic growth of human CRC cells in vitro and in vivo. Functionally, RGC32 facilitated epithelial-mesenchymal transition (EMT) in CRC via the Smad/Sip1 signaling pathway, as shown by decreasing E-cadherin expression and increasing vimentin expression. In conclusion, our findings suggested that overexpression of RGC32 facilitates EMT of CRC cells by activating Smad/Sip1 signaling.

Animal damage management handbook.

Science.gov (United States)

Hugh C. Black

1994-01-01

This handbook treats animal damage management (ADM) in the West in relation to forest, range, and recreation resources; predator management is not addressed. It provides a comprehensive reference of safe, effective, and practical methods for managing animal damage on National Forest System lands. Supporting information is included in references after each chapter and...

Nuclear safeguards technology handbook

International Nuclear Information System (INIS)

1977-12-01

The purpose of this handbook is to present to United States industrial organizations the Department of Energy's (DOE) Safeguards Technology Program. The roles and missions for safeguards in the U.S. government and application of the DOE technology program to industry safeguards planning are discussed. A guide to sources and products is included

Linear electric machines, drives, and MAGLEVs handbook

CERN Document Server

Boldea, Ion

2013-01-01

Based on author Ion Boldea's 40 years of experience and the latest research, Linear Electric Machines, Drives, and Maglevs Handbook provides a practical and comprehensive resource on the steady improvement in this field. The book presents in-depth reviews of basic concepts and detailed explorations of complex subjects, including classifications and practical topologies, with sample results based on an up-to-date survey of the field. Packed with case studies, this state-of-the-art handbook covers topics such as modeling, steady state, and transients as well as control, design, and testing of li

DOE Fundamentals Handbook: Electrical Science, Volume 2

International Nuclear Information System (INIS)

1992-06-01

The Electrical Science Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding terminology, and application. The handbook includes information on alternating current (AC) and direct current (DC) theory, circuits, motors, and generators; AC power and reactive components; batteries; AC and DC voltage regulators; transformers; and electrical test instruments and measuring devices. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility electrical equipment

DOE Fundamentals Handbook: Electrical Science, Volume 1

International Nuclear Information System (INIS)

1992-06-01

The Electrical Science Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of electrical theory, terminology, and application. The handbook includes information on alternating current (AC) and direct current (DC) theory, circuits, motors, and generators; AC power and reactive components; batteries; AC and DC voltage regulators; transformers; and electrical test instruments and measuring devices. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility electrical equipment

DOE Fundamentals Handbook: Electrical Science, Volume 3

International Nuclear Information System (INIS)

1992-06-01

The Electrical Science Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of electrical theory, terminology, and application. The handbook includes information on alternating current (AC) and direct current (DC) theory, circuits, motors and generators; AC power and reactive components; batteries; AC and DC voltage regulators; transformers; and electrical test instruments and measuring devices. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility electrical equipment

DOE Fundamentals Handbook: Electrical Science, Volume 4

International Nuclear Information System (INIS)

1992-06-01

The Electrical Science Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of electrical theory, terminology, and application. The handbook includes information on alternating current (AC) and direct current (DC) theory, circuits, motors, and generators; AC power and reactive transformers; and electrical test components; batteries; AC and DC voltage regulators; instruments and measuring devices. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility electrical equipment

Report: Cultural Research Centre (CRC)

OpenAIRE

Cross-Cultural Foundation of Uganda

2010-01-01

This report arises from research carried out in Iganga and Namutumba districts in late 2006/early 2007 by the Cultural Research Centre (CRC), based in Jinja. Our research focus was to gauge the impact of using Lusoga as a medium of instruction (since 2005 in "pilot" lower primary classes) within and outside the classroom. This initiative was in response to a new set of circumstances in the education sector in Uganda, especially the introduction by Government of teaching in local languages in ...

Perioperative FOLFOX4 plus bevacizumab for initially unresectable advanced colorectal cancer (NAVIGATE-CRC-01).

Science.gov (United States)

Suenaga, Mitsukuni; Fujimoto, Yoshiya; Matsusaka, Satoshi; Shinozaki, Eiji; Akiyoshi, Takashi; Nagayama, Satoshi; Fukunaga, Yosuke; Oya, Masatoshi; Ueno, Masashi; Mizunuma, Nobuyuki; Yamaguchi, Toshiharu

2015-01-01

Perioperative chemotherapy combined with surgery for liver metastases is considered an active strategy in metastatic colorectal cancer (CRC). However, its impact on initially unresectable, previously untreated advanced CRC, regardless of concurrent metastases, remains to be clarified. A Phase II study was conducted to evaluate the safety and efficacy of perioperative FOLFOX4 plus bevacizumab for initially unresectable advanced CRC. Patients with previously untreated advanced colon or rectal cancer initially diagnosed as unresectable advanced CRC (TNM stage IIIb, IIIc, or IV) but potentially resectable after neoadjuvant chemotherapy (NAC) were studied. Preoperatively, patients received six cycles of NAC (five cycles of neoadjuvant FOLFOX4 plus bevacizumab followed by one cycle of FOLFOX4 alone). The interval between the last dose of bevacizumab and surgery was at least 5 weeks. Six cycles of adjuvant FOLFOX4 plus bevacizumab were given after surgery. The completion rate of NAC and feasibility of curative surgery were the primary endpoints. An interim analysis was performed at the end of NAC in the 12th patient to assess the completion rate of NAC. The median follow-up time was 56 months. The characteristics of the patients were as follows: sex, eight males and four females; tumor location, sigmoid colon in three, ascending colon in one, and rectum (above the peritoneal reflection) in eight; stage, III in eight and IV in four (liver or lymph nodes). All patients completed six cycles of NAC. There were no treatment-related severe adverse events or deaths. An objective response to NAC was achieved in nine patients (75%), and no disease progression was observed. Eleven patients underwent curative tumor resection, including metastatic lesions. In December 2012, this Phase II study was terminated because of slow registration. Perioperative FOLFOX4 plus bevacizumab is well tolerated and has a promising response rate leading to curative surgery, which offers a survival

Handbook of industrial lighting

CERN Document Server

Lyons, Stanley L

2013-01-01

Handbook of Industrial Lighting is a practical guide on the specification, design, installation, operation, and maintenance of lighting in industrial premises. Coverage of the book includes the importance of good localized lighting; the different lighting schemes; lighting for difficult visual tasks; lighting in consideration to safety; and emergency lighting. The book also includes the practical, thermal, ventilation, and energy considerations; lighting in different environments; maintenance of lighting installations; and the cost benefits of efficient lighting. Appendices include useful info

Handbook of sustainable engineering

CERN Document Server

Lee, Kun-Mo

2013-01-01

"The efficient utilization of energy, sustainable use of natural resources, and large-scale adoption of sustainable technologies is the key to a sustainable future. The Handbook of Sustainable Engineering provides tools that will help us achieve these goals". Nobel Prize Winner Dr. R.K. Pauchauri, Chairman, UN Intergovernmental Panel on Climate Change As global society confronts the challenges of diminishing resources, ecological degradation, and climate change, engineers play a crucial role designing and building technologies and products that fulfil our needs for utility and sustainability. The Handbook of Sustainable Engineering equips readers with the context and the best practices derived from both academic research and practical examples of successful implementations of sustainable technical solutions. The handbook’s content revolves around the two themes, new ways of thinking and new business models, including sustainable production, products, service systems and consumption while addressing key asse...

Nuclear safeguards technology handbook

Energy Technology Data Exchange (ETDEWEB)

1977-12-01

The purpose of this handbook is to present to United States industrial organizations the Department of Energy's (DOE) Safeguards Technology Program. The roles and missions for safeguards in the U.S. government and application of the DOE technology program to industry safeguards planning are discussed. A guide to sources and products is included. (LK)

Influence of the Hfq and Crc global regulators on the control of iron homeostasis in Pseudomonas putida.

Science.gov (United States)

Sánchez-Hevia, Dione L; Yuste, Luis; Moreno, Renata; Rojo, Fernando

2018-04-30

Metabolically versatile bacteria use catabolite repression control to select their preferred carbon sources, thus optimizing carbon metabolism. In pseudomonads, this occurs through the combined action of the proteins Hfq and Crc, which form stable tripartite complexes at target mRNAs, inhibiting their translation. The activity of Hfq/Crc is antagonised by small RNAs of the CrcZ family, the amounts of which vary according to carbon availability. The present work examines the role of Pseudomonas putida Hfq protein under conditions of low-level catabolite repression, in which Crc protein would have a minor role since it is sequestered by CrcZ/CrcY. The results suggest that, under these conditions, Hfq remains operative and plays an important role in iron homeostasis. In this scenario, Crc appears to participate indirectly by helping CrcZ/CrcY to control the amount of free Hfq in the cell. Iron homeostasis in pseudomonads relies on regulatory elements such as the Fur protein, the PrrF1-F2 sRNAs, and several extracytoplasmic sigma factors. Our results show that the absence of Hfq is paralleled by a reduction in PrrF1-F2 small RNAs. Hfq thus provides a regulatory link between iron and carbon metabolism, coordinating the iron supply to meet the needs of the enzymes operational under particular nutritional regimes. This article is protected by copyright. All rights reserved. © 2018 Society for Applied Microbiology and John Wiley & Sons Ltd.

Nanobiomaterials handbook

CERN Document Server

Sitharaman, Balaji

2011-01-01

Nanobiomaterials exhibit distinctive characteristics, including mechanical, electrical, and optical properties, which make them suitable for a variety of biological applications. Because of their versatility, they are poised to play a central role in nanobiotechnology and make significant contributions to biomedical research and healthcare. Nanobiomaterials Handbook provides a comprehensive overview of the field, offering a broad introduction for those new to the subject as well as a useful reference for advanced professionals.Analyzing major topics and disciplines in this arena, this volume:

Virulence of Pseudomonas syringae pv. tomato DC3000 Is Influenced by the Catabolite Repression Control Protein Crc.

Science.gov (United States)

Chakravarthy, Suma; Butcher, Bronwyn G; Liu, Yingyu; D'Amico, Katherine; Coster, Matthew; Filiatrault, Melanie J

2017-04-01

Pseudomonas syringae infects diverse plant species and is widely used as a model system in the study of effector function and the molecular basis of plant diseases. Although the relationship between bacterial metabolism, nutrient acquisition, and virulence has attracted increasing attention in bacterial pathology, it is largely unexplored in P. syringae. The Crc (catabolite repression control) protein is a putative RNA-binding protein that regulates carbon metabolism as well as a number of other factors in the pseudomonads. Here, we show that deletion of crc increased bacterial swarming motility and biofilm formation. The crc mutant showed reduced growth and symptoms in Arabidopsis and tomato when compared with the wild-type strain. We have evidence that the crc mutant shows delayed hypersensitive response (HR) when infiltrated into Nicotiana benthamiana and tobacco. Interestingly, the crc mutant was more susceptible to hydrogen peroxide, suggesting that, in planta, the mutant may be sensitive to reactive oxygen species generated during pathogen-associated molecular pattern-triggered immunity (PTI). Indeed, HR was further delayed when PTI-induced tissues were challenged with the crc mutant. The crc mutant did not elicit an altered PTI response in plants compared with the wild-type strain. We conclude that Crc plays an important role in growth and survival during infection.

Handbook of energy use for building construction

Energy Technology Data Exchange (ETDEWEB)

Stein, R.G.; Stein, C.; Buckley, M.; Green, M.

1980-03-01

The construction industry accounts for over 11.14% of the total energy consumed in the US annually. This represents the equivalent energy value of 1 1/4 billion barrels of oil. Within the construction industry, new building construction accounts for 5.19% of national annual energy consumption. The remaining 5.95% is distributed among new nonbuilding construction (highways, ralroads, dams, bridges, etc.), building maintenance construction, and nonbuilding maintenance construction. The handbook focuses on new building construction; however, some information for the other parts of the construction industry is also included. The handbook provides building designers with information to determine the energy required for buildings construction and evaluates the energy required for alternative materials, assemblies, and methods. The handbook is also applicable to large-scale planning and policy determination in that it provides the means to estimate the energy required to carry out major building programs.

DOE Fundamentals Handbook: Classical Physics

International Nuclear Information System (INIS)

1992-06-01

The Classical Physics Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of physical forces and their properties. The handbook includes information on the units used to measure physical properties; vectors, and how they are used to show the net effect of various forces; Newton's Laws of motion, and how to use these laws in force and motion applications; and the concepts of energy, work, and power, and how to measure and calculate the energy involved in various applications. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility systems and equipment

Handbook on the Experience Economy

DEFF Research Database (Denmark)

This illuminating Handbook presents the state-of-the-art in the scientific field of experience economy studies. It offers a rich and varied collection of contributions that discuss different issues of crucial importance for our understanding of the experience economy. Each chapter reflects diverse...... an insight into how receivers react to experiential elements of experience economy studies. An innovative presentation of experience economics, this is a remarkable collection of new theory and analyses. This book will prove an invaluable resource to researchers and students in management, marketing...... scientific viewpoints from disciplines including management, mainstream economics and sociology to provide a comprehensive overview. The Handbook is divided into three subsections to explore progression in the scientific field of experience economy studies. The first section focuses on fundamental debates...

Interplay between the catabolite repression control protein Crc, Hfq and RNA in Hfq-dependent translational regulation in Pseudomonas aeruginosa.

Science.gov (United States)

Sonnleitner, Elisabeth; Wulf, Alexander; Campagne, Sébastien; Pei, Xue-Yuan; Wolfinger, Michael T; Forlani, Giada; Prindl, Konstantin; Abdou, Laetitia; Resch, Armin; Allain, Frederic H-T; Luisi, Ben F; Urlaub, Henning; Bläsi, Udo

2018-02-16

In Pseudomonas aeruginosa the RNA chaperone Hfq and the catabolite repression control protein (Crc) act as post-transcriptional regulators during carbon catabolite repression (CCR). In this regard Crc is required for full-fledged Hfq-mediated translational repression of catabolic genes. RNAseq based transcriptome analyses revealed a significant overlap between the Crc and Hfq regulons, which in conjunction with genetic data supported a concerted action of both proteins. Biochemical and biophysical approaches further suggest that Crc and Hfq form an assembly in the presence of RNAs containing A-rich motifs, and that Crc interacts with both, Hfq and RNA. Through these interactions, Crc enhances the stability of Hfq/Crc/RNA complexes, which can explain its facilitating role in Hfq-mediated translational repression. Hence, these studies revealed for the first time insights into how an interacting protein can modulate Hfq function. Moreover, Crc is shown to interfere with binding of a regulatory RNA to Hfq, which bears implications for riboregulation. These results are discussed in terms of a working model, wherein Crc prioritizes the function of Hfq toward utilization of favored carbon sources.

Gen IV Materials Handbook Functionalities and Operation

International Nuclear Information System (INIS)

Ren, Weiju

2009-01-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

Gen IV Materials Handbook Functionalities and Operation

Energy Technology Data Exchange (ETDEWEB)

Ren, Weiju [ORNL

2009-12-01

This document is prepared for navigation and operation of the Gen IV Materials Handbook, with architecture description and new user access initiation instructions. Development rationale and history of the Handbook is summarized. The major development aspects, architecture, and design principles of the Handbook are briefly introduced to provide an overview of its past evolution and future prospects. Detailed instructions are given with examples for navigating the constructed Handbook components and using the main functionalities. Procedures are provided in a step-by-step fashion for Data Upload Managers to upload reports and data files, as well as for new users to initiate Handbook access.

DOE Fundamentals Handbook: Instrumentation and Control, Volume 1

International Nuclear Information System (INIS)

1992-06-01

The Instrumentation and Control Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of instrumentation and control systems. The handbook includes information on temperature, pressure, flow, and level detection systems; position indication systems; process control systems; and radiation detection principles. This information will provide personnel with an understanding of the basic operation of various types of DOE nuclear facility instrumentation and control systems

DOE Fundamentals Handbook: Instrumentation and Control, Volume 1

Energy Technology Data Exchange (ETDEWEB)

1992-06-01

The Instrumentation and Control Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of instrumentation and control systems. The handbook includes information on temperature, pressure, flow, and level detection systems; position indication systems; process control systems; and radiation detection principles. This information will provide personnel with an understanding of the basic operation of various types of DOE nuclear facility instrumentation and control systems.

DOE Fundamentals Handbook: Instrumentation and Control, Volume 2

International Nuclear Information System (INIS)

1992-06-01

The Instrumentation and Control Fundamentals Handbook personnel, and the technical staff facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of instrumentation and control systems. The handbook includes information on temperature, pressure, flow, and level detection systems; position indication systems; process control systems; and radiation detection principles. This information will provide personnel with an understanding of the basic operation of various types of DOE nuclear facility instrumentation and control systems

FCRD Advanced Reactor (Transmutation) Fuels Handbook

Energy Technology Data Exchange (ETDEWEB)

Janney, Dawn Elizabeth [Idaho National Lab. (INL), Idaho Falls, ID (United States); Papesch, Cynthia Ann [Idaho National Lab. (INL), Idaho Falls, ID (United States)

2016-09-01

Transmutation of minor actinides such as Np, Am, and Cm in spent nuclear fuel is of international interest because of its potential for reducing the long-term health and safety hazards caused by the radioactivity of the spent fuel. One important approach to transmutation (currently being pursued by the DOE Fuel Cycle Research & Development Advanced Fuels Campaign) involves incorporating the minor actinides into U-Pu-Zr alloys, which can be used as fuel in fast reactors. U-Pu-Zr alloys are well suited for electrolytic refining, which leads to incorporation rare-earth fission products such as La, Ce, Pr, and Nd. It is, therefore, important to understand not only the properties of U-Pu-Zr alloys but also those of U-Pu-Zr alloys with concentrations of minor actinides (Np, Am) and rare-earth elements (La, Ce, Pr, and Nd) similar to those in reprocessed fuel. In addition to requiring extensive safety precautions, alloys containing U, Pu, and minor actinides (Np and Am) are difficult to study for numerous reasons, including their complex phase transformations, characteristically sluggish phasetransformation kinetics, tendency to produce experimental results that vary depending on the histories of individual samples, rapid oxidation, and sensitivity to contaminants such as oxygen in concentrations below a hundred parts per million. Although less toxic, rare-earth elements such as La, Ce, Pr, and Nd are also difficult to study for similar reasons. Many of the experimental measurements were made before 1980, and the level of documentation for experimental methods and results varies widely. It is, therefore, not surprising that little is known with certainty about U-Pu-Zr alloys, particularly those that also contain minor actinides and rare-earth elements. General acceptance of results commonly indicates that there is only a single measurement for a particular property. This handbook summarizes currently available information about U, Pu, Zr, Np, Am, La, Ce, Pr, and Nd and

Radiation`96. Conference handbook

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-12-31

The conference program includes eight invited lectures which cover a range of contemporary topics in radiation science and technology. In addition, thirty-two oral papers were presented, along with forty-five posters. The conference handbook contains one-page precis or extended abstracts of all presentations, and is a substantial compendium of current radiation research in Australia.

Radiation`96. Conference handbook

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-12-31

The conference program includes eight invited lectures which cover a range of contemporary topics in radiation science and technology. In addition, thirty-two oral papers were presented, along with forty-five posters. The conference handbook contains one-page precis or extended abstracts of all presentations, and is a substantial compendium of current radiation research in Australia.

Radiation'96. Conference handbook

International Nuclear Information System (INIS)

1996-01-01

The conference program includes eight invited lectures which cover a range of contemporary topics in radiation science and technology. In addition, thirty-two oral papers were presented, along with forty-five posters. The conference handbook contains one-page precis or extended abstracts of all presentations, and is a substantial compendium of current radiation research in Australia

The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis.

Science.gov (United States)

Song, Lele; Jia, Jia; Peng, Xiumei; Xiao, Wenhua; Li, Yuemin

2017-06-08

The SEPT9 gene methylation assay is the first FDA-approved blood assay for colorectal cancer (CRC) screening. Fecal immunochemical test (FIT), FIT-DNA test and CEA assay are also in vitro diagnostic (IVD) tests used in CRC screening. This meta-analysis aims to review the SEPT9 assay performance and compare it with other IVD CRC screening tests. By searching the Ovid MEDLINE, EMBASE, CBMdisc and CJFD database, 25 out of 180 studies were identified to report the SEPT9 assay performance. 2613 CRC cases and 6030 controls were included, and sensitivity and specificity were used to evaluate its performance at various algorithms. 1/3 algorithm exhibited the best sensitivity while 2/3 and 1/1 algorithm exhibited the best balance between sensitivity and specificity. The performance of the blood SEPT9 assay is superior to that of the serum protein markers and the FIT test in symptomatic population, while appeared to be less potent than FIT and FIT-DNA tests in asymptomatic population. In conclusion, 1/3 algorithm is recommended for CRC screening, and 2/3 or 1/1 algorithms are suitable for early detection for diagnostic purpose. The SEPT9 assay exhibited better performance in symptomatic population than in asymptomatic population.

Procurement Career Management Handbook.

Science.gov (United States)

Department of the Treasury, Washington, DC.

This handbook is the result of the Treasury Department's efforts to increase professionalism among its procurement employees nationwide through its Procurement Career Management Program. First, the scope and objectives of the Procurement Career Management Program are discussed. The remaining sections of the handbook deal with the following program…

75 FR 8575 - Testing of Certain High Production Volume Chemicals; Third Group of Chemicals

Science.gov (United States)

2010-02-25

...: Beilstein Database, CRC Handbook of Chemistry and Physics, Hawley's Condensed Chemical Dictionary, Illustrated Handbooks of Physical- Chemical Properties and Environmental Fate for Organic Chemicals, Merck... Coefficient: Method A (40 CFR 799.6755--shake flask). Method B (ASTM E 1147-92(2005)--liquid chromatography...

Precision Medicine for CRC Patients in the Veteran Population: State-of-the-Art, Challenges and Research Directions.

Science.gov (United States)

Mohapatra, Shyam S; Batra, Surinder K; Bharadwaj, Srinivas; Bouvet, Michael; Cosman, Bard; Goel, Ajay; Jogunoori, Wilma; Kelley, Michael J; Mishra, Lopa; Mishra, Bibhuti; Mohapatra, Subhra; Patel, Bhaumik; Pisegna, Joseph R; Raufman, Jean-Pierre; Rao, Shuyun; Roy, Hemant; Scheuner, Maren; Singh, Satish; Vidyarthi, Gitanjali; White, Jon

2018-05-01

Colorectal cancer (CRC) accounts for ~9% of all cancers in the Veteran population, a fact which has focused a great deal of the attention of the VA's research and development efforts. A field-based meeting of CRC experts was convened to discuss both challenges and opportunities in precision medicine for CRC. This group, designated as the VA Colorectal Cancer Cell-genomics Consortium (VA4C), discussed advances in CRC biology, biomarkers, and imaging for early detection and prevention. There was also a discussion of precision treatment involving fluorescence-guided surgery, targeted chemotherapies and immunotherapies, and personalized cancer treatment approaches. The overarching goal was to identify modalities that might ultimately lead to personalized cancer diagnosis and treatment. This review summarizes the findings of this VA field-based meeting, in which much of the current knowledge on CRC prescreening and treatment was discussed. It was concluded that there is a need and an opportunity to identify new targets for both the prevention of CRC and the development of effective therapies for advanced disease. Also, developing methods integrating genomic testing with tumoroid-based clinical drug response might lead to more accurate diagnosis and prognostication and more effective personalized treatment of CRC.

Warehouse Sanitation Workshop Handbook.

Science.gov (United States)

Food and Drug Administration (DHHS/PHS), Washington, DC.

This workshop handbook contains information and reference materials on proper food warehouse sanitation. The materials have been used at Food and Drug Administration (FDA) food warehouse sanitation workshops, and are selected by the FDA for use by food warehouse operators and for training warehouse sanitation employees. The handbook is divided…

Travel time data collection handbook

Science.gov (United States)

1998-03-01

This Travel Time Data Collection Handbook provides guidance to transportation : professionals and practitioners for the collection, reduction, and presentation : of travel time data. The handbook should be a useful reference for designing : travel ti...

Handbook for evaluation studies in virtual reality

DEFF Research Database (Denmark)

Livatino, Salvatore; Koeffel, Christina

2006-01-01

of human behavior including aspects of perception, action, and task-performance. The evaluation issue calls for multi- and interdisciplinary research activities, where technical expertise is combined with humanistic knowledge and methodology. Several experts in the field of VR as well as in the field...... in evaluation studies as well as students. The aim is also to facilitate multi-disciplinary activities through the use of an evaluation handbook which would be simple and focused on VR. The applicability of this guideline has been tested in two pilot studies, which showed how this handbook could successfully...... be employed to carry out pilot (and formal) evaluations....

Handbook of social network technologies and applications

CERN Document Server

Furht, Borko

2010-01-01

Social networking is a concept that has existed for a long time; however, with the explosion of the Internet, social networking has become a tool for people to connect and communicate in ways that were impossible in the past. The recent development of Web 2.0 has provided many new applications, such as Myspace, Facebook, and LinkedIn. The purpose of ""Handbook of Social Networks: Technologies and Applications"" is to provide comprehensive guidelines on the current and future trends in social network technologies and applications in the field of Web-based Social Networks. This handbook includes

Dentistry and Dental Hygiene Handbook.

Science.gov (United States)

New York State Education Dept., Albany. Office of the Professions.

The handbook contains laws, rules, and regulations of the New York State Education Department that govern dentistry and dental hygiene practice in the state. It describes licensure requirements and includes complete application forms and instructions for obtaining license and first registration as a dentist and dental hygienist. Applicants are…

DOE fundamentals handbook: Nuclear physics and reactor theory

International Nuclear Information System (INIS)

1993-01-01

The Nuclear Physics and Reactor Theory Handbook was developed to assist nuclear facility operating contractors in providing operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of nuclear physics and reactor theory. The handbook includes information on atomic and nuclear physics; neutron characteristics; reactor theory and nuclear parameters; and the theory of reactor operation. This information will provide personnel with a foundation for understanding the scientific principles that are associated with various DOE nuclear facility operations and maintenance

Safety analysis and risk assessment handbook

International Nuclear Information System (INIS)

Peterson, V.L.; Colwell, R.G.; Dickey, R.L.

1997-01-01

This Safety Analysis and Risk Assessment Handbook (SARAH) provides guidance to the safety analyst at the Rocky Flats Environmental Technology Site (RFETS) in the preparation of safety analyses and risk assessments. Although the older guidance (the Rocky Flats Risk Assessment Guide) continues to be used for updating the Final Safety Analysis Reports developed in the mid-1980s, this new guidance is used with all new authorization basis documents. With the mission change at RFETS came the need to establish new authorization basis documents for its facilities, whose functions had changed. The methodology and databases for performing the evaluations that support the new authorization basis documents had to be standardized, to avoid the use of different approaches and/or databases for similar accidents in different facilities. This handbook presents this new standardized approach. The handbook begins with a discussion of the requirements of the different types of authorization basis documents and how to choose the one appropriate for the facility to be evaluated. It then walks the analyst through the process of identifying all the potential hazards in the facility, classifying them, and choosing the ones that need to be analyzed further. It then discusses the methods for evaluating accident initiation and progression and covers the basic steps in a safety analysis, including consequence and frequency binning and risk ranking. The handbook lays out standardized approaches for determining the source terms of the various accidents (including airborne release fractions, leakpath factors, etc.), the atmospheric dispersion factors appropriate for Rocky Flats, and the methods for radiological and chemical consequence assessments. The radiological assessments use a radiological open-quotes templateclose quotes, a spreadsheet that incorporates the standard values of parameters, whereas the chemical assessments use the standard codes ARCHIE and ALOHA

Therapeutic value of EGFR inhibition in CRC and NSCLC: 15 years of clinical evidence.

Science.gov (United States)

Troiani, Teresa; Napolitano, Stefania; Della Corte, Carminia Maria; Martini, Giulia; Martinelli, Erika; Morgillo, Floriana; Ciardiello, Fortunato

2016-01-01

Epidermal growth factor receptor (EGFR) plays a key role in tumour evolution, proliferation and immune evasion, and is one of the most important targets for biological therapy, especially for non-small-cell lung cancer (NSCLC) and colorectal cancer (CRC). In the past 15 years, several EGFR antagonists have been approved for the treatment of NSCLC and metastatic CRC (mCRC). To optimise the use of anti-EGFR agents in clinical practice, various clinical and molecular biomarkers have been investigated, thus moving their indication from unselected to selected populations. Nowadays, anti-EGFR drugs represent a gold-standard therapy for metastatic NSCLC harbouring EGFR activating mutation and for RAS wild-type mCRC. Their clinical efficacy is limited by the presence of intrinsic resistance or the onset of acquired resistance. In this review, we provide an overview of the antitumour activity of EGFR inhibitors in NSCLC and CRC and of mechanisms of resistance, focusing on the development of a personalised approach through 15 years of preclinical and clinical research.

Mobile retroreflectivity best practices handbook.

Science.gov (United States)

2009-07-01

This handbook documents best practices related to proper use of the mobile retroreflectometer, sampling of : sites for data collection, and handling of mobile retroreflectivity data. The best practices described in this : handbook are derived from th...

Protein kinase C zeta suppresses low- or high-grade colorectal cancer (CRC) phenotypes by interphase centrosome anchoring.

Science.gov (United States)

Deevi, Ravi Kiran; Javadi, Arman; McClements, Jane; Vohhodina, Jekaterina; Savage, Kienan; Loughrey, Maurice Bernard; Evergren, Emma; Campbell, Frederick Charles

2018-04-01

Histological grading provides prognostic stratification of colorectal cancer (CRC) by scoring heterogeneous phenotypes. Features of aggressiveness include aberrant mitotic spindle configurations, chromosomal breakage, and bizarre multicellular morphology, but pathobiology is poorly understood. Protein kinase C zeta (PKCz) controls mitotic spindle dynamics, chromosome segregation, and multicellular patterns, but its role in CRC phenotype evolution remains unclear. Here, we show that PKCz couples genome segregation to multicellular morphology through control of interphase centrosome anchoring. PKCz regulates interdependent processes that control centrosome positioning. Among these, interaction between the cytoskeletal linker protein ezrin and its binding partner NHERF1 promotes the formation of a localized cue for anchoring interphase centrosomes to the cell cortex. Perturbation of these phenomena induced different outcomes in cells with single or extra centrosomes. Defective anchoring of a single centrosome promoted bipolar spindle misorientation, multi-lumen formation, and aberrant epithelial stratification. Collectively, these disturbances induce cribriform multicellular morphology that is typical of some categories of low-grade CRC. By contrast, defective anchoring of extra centrosomes promoted multipolar spindle formation, chromosomal instability (CIN), disruption of glandular morphology, and cell outgrowth across the extracellular matrix interface characteristic of aggressive, high-grade CRC. Because PKCz enhances apical NHERF1 intensity in 3D epithelial cultures, we used an immunohistochemical (IHC) assay of apical NHERF1 intensity as an indirect readout of PKCz activity in translational studies. We show that apical NHERF1 IHC intensity is inversely associated with multipolar spindle frequency and high-grade morphology in formalin-fixed human CRC samples. To conclude, defective PKCz control of interphase centrosome anchoring may underlie distinct categories of

MEG3 is a prognostic factor for CRC and promotes chemosensitivity by enhancing oxaliplatin-induced cell apoptosis.

Science.gov (United States)

Li, Lixia; Shang, Jian; Zhang, Yupeng; Liu, Shi; Peng, Yanan; Zhou, Zhou; Pan, Huaqing; Wang, Xiaobing; Chen, Lipng; Zhao, Qiu

2017-09-01

A major reason for the failure of advanced colorectal cancer (CRC) treatment is the occurrence of chemoresistance to oxaliplatin-based chemotherapy. Recently, studies have shown that long non-coding RNAs (lncRNAs) play an important role in drug resistance. Using HiSeq sequencing methods, we identified that lncRNAs show differential expression levels in oxaliplatin-resistant (OxR) and non-resistant CRC patients. RT-qPCR was then performed in tissues and serum samples, and lncRNA MEG3 was verified to be downregulated in non-responding patients and to have considerable discriminating potential to identify responding patients from non-responding patients. Moreover, decreased serum MEG3 expression was associated with poor chemoresponse and low survival rate in CRC patients receiving oxaliplatin treatment. Subsequently, OxR cell lines were established, and MEG3 was significantly downregulated in HT29 OxR and SW480 OxR cells. In addition, overexpression of MEG3 with pMEG3 reversed oxaliplatin resistance in both CRC cell lines. Flow cytometric apoptosis analysis indicated that MEG3 promoted CRC cell apoptosis. More importantly, MEG3 enhanced oxaliplatin‑induced cell cytotoxicity in CRC. In conclusion, our integrated approach demonstrated that decreased expression of lncRNA MEG3 in CRC confers potent poor therapeutic efficacy, and that MEG3 promotes chemosensitivity by enhancing oxaliplatin-induced cell apoptosis. Thus, overexpression of MEG3 may be a future direction by which to develop a novel therapeutic strategy to overcome oxaliplatin resistance of CRC patients.

Novel targets of the CbrAB/Crc carbon catabolite control system revealed by transcript abundance in Pseudomonas aeruginosa.

Science.gov (United States)

Sonnleitner, Elisabeth; Valentini, Martina; Wenner, Nicolas; Haichar, Feth el Zahar; Haas, Dieter; Lapouge, Karine

2012-01-01

The opportunistic human pathogen Pseudomonas aeruginosa is able to utilize a wide range of carbon and nitrogen compounds, allowing it to grow in vastly different environments. The uptake and catabolism of growth substrates are organized hierarchically by a mechanism termed catabolite repression control (Crc) whereby the Crc protein establishes translational repression of target mRNAs at CA (catabolite activity) motifs present in target mRNAs near ribosome binding sites. Poor carbon sources lead to activation of the CbrAB two-component system, which induces transcription of the small RNA (sRNA) CrcZ. This sRNA relieves Crc-mediated repression of target mRNAs. In this study, we have identified novel targets of the CbrAB/Crc system in P. aeruginosa using transcriptome analysis in combination with a search for CA motifs. We characterized four target genes involved in the uptake and utilization of less preferred carbon sources: estA (secreted esterase), acsA (acetyl-CoA synthetase), bkdR (regulator of branched-chain amino acid catabolism) and aroP2 (aromatic amino acid uptake protein). Evidence for regulation by CbrAB, CrcZ and Crc was obtained in vivo using appropriate reporter fusions, in which mutation of the CA motif resulted in loss of catabolite repression. CbrB and CrcZ were important for growth of P. aeruginosa in cystic fibrosis (CF) sputum medium, suggesting that the CbrAB/Crc system may act as an important regulator during chronic infection of the CF lung.

Overview of the 2014 Edition of the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook)

Energy Technology Data Exchange (ETDEWEB)

John D. Bess; J. Blair Briggs; Jim Gulliford; Ian Hill

2014-10-01

The International Reactor Physics Experiment Evaluation Project (IRPhEP) is a widely recognized world class program. The work of the IRPhEP is documented in the International Handbook of Evaluated Reactor Physics Benchmark Experiments (IRPhEP Handbook). Integral data from the IRPhEP Handbook is used by reactor safety and design, nuclear data, criticality safety, and analytical methods development specialists, worldwide, to perform necessary validations of their calculational techniques. The IRPhEP Handbook is among the most frequently quoted reference in the nuclear industry and is expected to be a valuable resource for future decades.

A Handbook for Teacher Leaders.

Science.gov (United States)

Pellicer, Leonard O.; Anderson, Lorin W.

This handbook is written for teachers in leadership roles, including team leaders, lead teachers, department chairpersons, and master teachers. Part 1, "The Nature of School Leadership," is devoted to a description of teacher leaders and how they lead. Results are provided from research on teacher leaders, and persistent obstacles to…

DcR3 induces epithelial-mesenchymal transition through activation of the TGF-β3/SMAD signaling pathway in CRC.

Science.gov (United States)

Liu, Yan-Ping; Zhu, Hui-Fang; Liu, Ding-Li; Hu, Zhi-Yan; Li, Sheng-Nan; Kan, He-Ping; Wang, Xiao-Yan; Li, Zu-Guo

2016-11-22

Decoy receptor 3 (DcR3), a novel member of the tumor necrosis factor receptor (TNFR) family, was recently reported to be associated with tumorigenesis and metastasis. However, the role of DcR3 in human colorectal cancer (CRC) has not been fully elucidated. In this study, we found that DcR3 expression was significantly higher in human colorectal cancer tissues than in paired normal tissues, and that DcR3 expression was strongly correlated with tumor invasion, lymph node metastases and poor prognoses. Moreover, DcR3 overexpression significantly enhanced CRC cell proliferation and migration in vitro and tumorigenesis in vivo. Conversely, DcR3 knockdown significantly repressed CRC cell proliferation and migration in vitro, and DcR3 deficiency also attenuated CRC tumorigenesis and metastasis in vivo. Functionally, DcR3 was essential for TGF-β3/SMAD-mediated epithelial-mesenchymal transition (EMT) of CRC cells. Importantly, cooperation between DcR3 and TGF-β3/SMAD-EMT signaling-related protein expression was correlated with survival and survival time in CRC patients. In conclusion, our results demonstrate that DcR3 may be a prognostic biomarker for CRC and that this receptor facilitates CRC development and metastasis by participating in TGF-β3/SMAD-mediated EMT of CRC cells.

Present status of Japanese Criticality Safety Handbook

International Nuclear Information System (INIS)

Okuno, Hiroshi

1999-01-01

A draft of the second edition of Nuclear Criticality Safety Handbook has been finalized, and it is under examination by reviewing committee for JAERI Report. Working Group designated for revising the Japanese Criticality Safety Handbook, which is chaired by Prof. Yamane, is now preparing for 'Guide on Burnup Credit for Storage and Transport of Spent Nuclear Fuel' and second edition of 'Data Collection' part of Handbook. Activities related to revising the Handbook might give a hint for a future experiment at STACY. (author)

Safety and environmental health handbook

Science.gov (United States)

,

1989-01-01

This Safety Handbook (445-1-H.) supplements the Geological Survey Safety Management Program objectives set forth in Survey Manual 445.1. Specifically, it provides a compact source of basic information to assist management and employees in preventing motor vehicle accidents, personal injuries, occupational diseases, fire, and other property damage or loss. All work situations incidental to the Geological Survey cannot be discussed in a handbook, and such complete coverage is not intended in this document. However, a wide range of subjects are covered in which a "common sense" approach to safety has been expressed. These subjects have been organized such that Chapters 1-5 address administrative issues, Chapters 6-12 address activities usually conducted within a facility, and Chapters 13-20 address field activities. No information contained in the Handbook is intended to alter any provision of any Federal law or executive order, Department of the Interior or Survey directive, or collective bargaining agreement. Questions or suggestions regarding the content of the Safety Handbook may be directed to the Survey Safety Manager, Administrative Division, Office of Facilities and Management Services, National Center, Reston, Virginia, Mail Stop 246. The previous edition of the Safety Handbook is superseded.

Handbook of reflector antennas and feed systems v.3 applications of reflectors

CERN Document Server

Rao, Sudhakar; Sharma, Satish K

2013-01-01

This is the first truly comprehensive and most up-to-date handbook available on modern reflector antennas and feed sources for diversified space and ground applications. There has never been such an all-encompassing reflector handbook in print, and no currently available title offers coverage of such recent research developments. The Handbook consists of three volumes. Volume III focuses on the range of reflector antenna applications, including space, terrestrial, and radar. The intent of this book volume is to provide practical applications and design information on reflector antennas used fo

International handbook of coal petrography. 2nd ed.

Energy Technology Data Exchange (ETDEWEB)

Crosdale, P. (ed.)

2001-07-01

This handbook is a CD-ROM version of the 1963 edition which was produced as a series of scanned tiff files with some corrections added. The handbook contains an alphabetical list of terms pertaining to brown coal petrography. Only terms recognised by a majority of experienced world petrographers are included. Generally, each of the terms contains sections on the origin of the term, a description of its constituents and properties, botanical affinities and genesis, alteration during coalification, occurrence and practical importance. Other sections cover other nomenclature systems, synonyms and analogous terms, and petrographic analysis methods.

Handbook of differential equations stationary partial differential equations

CERN Document Server

Chipot, Michel

2006-01-01

This handbook is volume III in a series devoted to stationary partial differential quations. Similarly as volumes I and II, it is a collection of self contained state-of-the-art surveys written by well known experts in the field. The topics covered by this handbook include singular and higher order equations, problems near critically, problems with anisotropic nonlinearities, dam problem, T-convergence and Schauder-type estimates. These surveys will be useful for both beginners and experts and speed up the progress of corresponding (rapidly developing and fascinating) areas of mathematics. Ke

IRPhEP-handbook, International Handbook of Evaluated Reactor Physics Benchmark Experiments

International Nuclear Information System (INIS)

Sartori, Enrico; Blair Briggs, J.

2008-01-01

1 - Description: The purpose of the International Reactor Physics Experiment Evaluation Project (IRPhEP) is to provide an extensively peer-reviewed set of reactor physics-related integral data that can be used by reactor designers and safety analysts to validate the analytical tools used to design next-generation reactors and establish the safety basis for operation of these reactors. This work of the IRPhEP is formally documented in the 'International Handbook of Evaluated Reactor Physics Benchmark Experiments,' a single source of verified and extensively peer-reviewed reactor physics benchmark measurements data. The IRPhE Handbook is available on DVD. You may request a DVD by completing the DVD Request Form available at: http://irphep.inl.gov/handbook/hbrequest.shtml The evaluation process entails the following steps: 1. Identify a comprehensive set of reactor physics experimental measurements data, 2. Evaluate the data and quantify overall uncertainties through various types of sensitivity analysis to the extent possible, verify the data by reviewing original and subsequently revised documentation, and by talking with the experimenters or individuals who are familiar with the experimental facility, 3. Compile the data into a standardized format, 4. Perform calculations of each experiment with standard reactor physics codes where it would add information, 5. Formally document the work into a single source of verified and peer reviewed reactor physics benchmark measurements data. The International Handbook of Evaluated Reactor Physics Benchmark Experiments contains reactor physics benchmark specifications that have been derived from experiments that were performed at various nuclear experimental facilities around the world. The benchmark specifications are intended for use by reactor physics personal to validate calculational techniques. The 2008 Edition of the International Handbook of Evaluated Reactor Physics Experiments contains data from 25 different

Harwell emergency handbook

International Nuclear Information System (INIS)

1986-12-01

The Harwell Laboratory Emergency Handbook 1987 contains emergency procedures to deal with any incident which might occur at AERE Harwell involving radioactive or toxic material releases. The Handbook gives details of the duties of members of the Site Emergency Organization and other key members of staff, the methods by which incidents are controlled, the communication links and liaison arrangements with other organizations and the possible consequences and actions that may be needed following an emergency. (UK)

Biogas/biofertilizer business handbook (third edition)

Energy Technology Data Exchange (ETDEWEB)

Arnott, M.

1985-07-01

The handbook covers biogas systems, including raw material preparation, digesters, separate gas storage tanks, use of gas to run engines, and the use of sludge as fertilizer. Also covers secondary projects such as flat-plate solar collector water heaters, composting, and bio-insecticides.

The electric motor handbook

Energy Technology Data Exchange (ETDEWEB)

Hurst, R.W.; Feltham, P. (eds.)

2004-05-01

This handbook outlines the important role that electric motors play in modern society. It covers the field of motor applications from various motor types to their use and repair. It also presents practical applications of electric motors and methods on motor efficiency. More than half of all electricity generated, and 75 per cent of all industrial electricity consumption is consumed by electric motors. Electrical personnel must be aware of all factors involved in electric motors in order to choose and apply the appropriate size of electric motor. These factors include efficiency, sizing and proper application. The efficient use and maximum life expectancy of electric motors depends on proper motor protection, control and maintenance. This handbook includes articles from leading experts on electric motors in modern electrical systems. The content includes: design considerations; proper electric motor sizing techniques; optimal electric motor application; electric motor protection technology; electric motor control principles; electric motor maintenance and troubleshooting; induction electric motors; electric motor bearing currents; electric motor bearing lubrication; electromagnetism; electric motor enclosures; electric motor testing; electric motor repair; DC electric motor; electric motor starters; electric motor brushes; industrial electric motors; electric motor diagrams; AC electric motors; electric motor wiring; electric motor service; electric motor rewinding; electric motor winding; diagram of electric motor wiring; electric motor kit; and, troubleshooting electric motors. A directory of motor manufacturers and suppliers was also included. refs., tabs., figs.

Direct utilization of geothermal energy: a technical handbook

Energy Technology Data Exchange (ETDEWEB)

Anderson, D.N; Lund, J.W. (eds.)

1979-01-01

This technical handbook includes comprehensive discussions on nature and occurrence of the geothermal resource, its development, utilization, economics, financing, and regulation. Information on pricing parameters for the direct use of geothermal energy is included as an appendix. (MRH)

The Crc global regulator inhibits the Pseudomonas putida pWW0 toluene/xylene assimilation pathway by repressing the translation of regulatory and structural genes.

Science.gov (United States)

Moreno, Renata; Fonseca, Pilar; Rojo, Fernando

2010-08-06

In Pseudomonas putida, the expression of the pWW0 plasmid genes for the toluene/xylene assimilation pathway (the TOL pathway) is subject to complex regulation in response to environmental and physiological signals. This includes strong inhibition via catabolite repression, elicited by the carbon sources that the cells prefer to hydrocarbons. The Crc protein, a global regulator that controls carbon flow in pseudomonads, has an important role in this inhibition. Crc is a translational repressor that regulates the TOL genes, but how it does this has remained unknown. This study reports that Crc binds to sites located at the translation initiation regions of the mRNAs coding for XylR and XylS, two specific transcription activators of the TOL genes. Unexpectedly, eight additional Crc binding sites were found overlapping the translation initiation sites of genes coding for several enzymes of the pathway, all encoded within two polycistronic mRNAs. Evidence is provided supporting the idea that these sites are functional. This implies that Crc can differentially modulate the expression of particular genes within polycistronic mRNAs. It is proposed that Crc controls TOL genes in two ways. First, Crc inhibits the translation of the XylR and XylS regulators, thereby reducing the transcription of all TOL pathway genes. Second, Crc inhibits the translation of specific structural genes of the pathway, acting mainly on proteins involved in the first steps of toluene assimilation. This ensures a rapid inhibitory response that reduces the expression of the toluene/xylene degradation proteins when preferred carbon sources become available.

DEAD-box helicase 27 promotes colorectal cancer growth and metastasis and predicts poor survival in CRC patients.

Science.gov (United States)

Tang, Jieting; Chen, Huarong; Wong, Chi-Chun; Liu, Dabin; Li, Tong; Wang, Xiaohong; Ji, Jiafu; Sung, Joseph Jy; Fang, Jing-Yuan; Yu, Jun

2018-03-14

Copy number alterations (CNAs) are crucial for colorectal cancer (CRC) development. In this study, DEAD box polypeptide 27 (DDX27) was identified to be highly amplified in both TCGA CRC (474/615) and primary CRC (47/103), which was positively correlated with its mRNA overexpression. High DDX27 mRNA (N = 199) and protein expression (N = 260) predicted poor survival in CRC patients. Ectopic expression of DDX27 increased CRC cells proliferation, migration and invasion, but suppressed apoptosis. Conversely, silencing of DDX27 exerted opposite effects in vitro and significantly inhibited murine xenograft tumor growth and lung metastasis in vivo. Up-regulation of DDX27 enhanced and prolonged TNF-α-mediated NF-κB signaling. Nucleophosmin (NPM1) was identified as a binding partner of DDX27. DDX27 increased nuclear NPM1 and NF-κB-p65 interaction to enhance DNA binding activity of NF-κB. Silencing NPM1 abrogated DDX27-activating NF-κB signaling and its tumor-promoting function. Together, DDX27 is overexpressed and plays a pivotal oncogenic role in CRC.

miR-133b down-regulates ABCC1 and enhances the sensitivity of CRC to anti-tumor drugs.

Science.gov (United States)

Chen, Miao; Li, Daojiang; Gong, Ni; Wu, Hao; Su, Chen; Xie, Canbin; Xiang, Hong; Lin, Changwei; Li, Xiaorong

2017-08-08

Multidrug resistance (MDR) is the main cause of failed chemotherapy treatments. Therefore, preventing MDR is pivotal in treating colorectal cancer (CRC). In a previous study miR-133b was shown to be a tumor suppressor. Additionally, in CRC cells transfected with miR-133b, ATP-binding cassette (ABC) subfamily C member 1(ABCC1) was shown to be significantly down regulated. Whether miR-133b also enhances the chemosensitivity of drugs used to treat CRC by targeting ABCC1 is still unclear. Here, we utilized flow cytometry and high-performance liquid chromatography (HPLC) analysis to identify the ability of miR-133b to reserve MDR in CRC. We then used a dual-luciferase reporter assay to validate that miR-133b targets ABCC1. Further in vivo experiments were designed to validate the method in which miR-133b reversed MDR in CRC cells. The results demonstrated that the level of miR-133b was down-regulated and the expression of ABCC1 was up-regulated in drug-resistant CRC cells compared to non-drug-resistant CRC cells. The restoration of miR-133b expression in CRC drug-resistant cells in vitro resulted in reduced IC50s to chemotherapeutic drugs, significantly induced G1 accumulation, inhibited growth and promoted necrosis in combination with either 5-fluorouracil (5-FU) or vincristine (VCR), and decreased the expression of ABCC1. The dual-luciferase assay demonstrated that miR-133b directly targets ABCC1. The combination of agomiRNA-133b with chemotherapeutic drugs in vivo inhibited tumor growth induced by CRC drug-resistant cells. A xenograft from the in vivo model resulted in up-regulated levels of miR-133b and down-regulated levels of ABCC1. Therefore, miR-133b enhances the chemosensitivity of CRC cells to anti-tumor drugs by directly down-regulating ABCC1. This discovery provides a therapeutic strategy in which miR-133b is used as a potential sensitizer for drug-resistant CRC.

The development of a packaging handbook

International Nuclear Information System (INIS)

Shappert, L.B.

1994-01-01

The Packaging Handbook, dealing with the development of packagings designed to carry radioactive material, is being written for DOE's Transportation and Packaging Safety Division. The primary goal of the Handbook is to provide sufficient technical information and guidance to improve the quality of Safety Analysis Reports on Type B Packagings (SARPs) that are submitted to DOE for certification. This paper provides an update on the status of the Handbook

Springer handbook of spacetime

CERN Document Server

Petkov, Vesselin

2014-01-01

The Springer Handbook of Spacetime is dedicated to the ground-breaking paradigm shifts embodied in the two relativity theories, and describes in detail the profound reshaping of physical sciences they ushered in. It includes in a single volume chapters on foundations, on the underlying mathematics, on physical and astrophysical implications, experimental evidence and cosmological predictions, as well as chapters on efforts to unify general relativity and quantum physics. The Handbook can be used as a desk reference by researchers in a wide variety of fields, not only by specialists in relativity but also by researchers in related areas that either grew out of, or are deeply influenced by, the two relativity theories: cosmology, astronomy and astrophysics, high energy physics, quantum field theory, mathematics, and philosophy of science. It should also serve as a valuable resource for graduate students and young researchers entering these areas, and for instructors who teach courses on these subjects. The Han...

Statistical handbook for Canada's upstream petroleum industry: '96 updates

International Nuclear Information System (INIS)

1997-01-01

The Statistical Handbook of CAPP is an annual compilation of useful information about the Canadian petroleum and natural gas industry. It has been published since 1955, and is a key source of upstream petroleum statistics. It presents a historical summary of the petroleum industry''s progress and provides detailed statistical information on the production and consumption of petroleum, petroleum products, natural gas and natural gas liquids, imports and exports, land sales, pipelines, reserves, drilling and refinery activities, and prices in Canada. The information, mostly in tabular form, is based on the latest available data (generally up to and including 1996). For the first time in 1997, the Handbook is also made available in CD-ROM format (EXCEL 5.0). Plans are also underway to publish the Handbook on a secure site on the Internet

Practical electronics handbook

CERN Document Server

Sinclair, Ian R

2013-01-01

Practical Electronics Handbook, Third Edition provides the frequently used and highly applicable principles of electronics and electronic circuits.The book contains relevant information in electronics. The topics discussed in the text include passive and active discrete components; linear and digital I.C.s; microprocessors and microprocessor systems; digital-analogue conversions; computer aids in electronics design; and electronic hardware components.Electronic circuit constructors, service engineers, electronic design engineers, and anyone with an interest in electronics will find the book ve

Newnes communications technology handbook

CERN Document Server

Lewis, Geoff

1994-01-01

Newnes Communications Technology Handbook provides a discussion on different topics relevant to communications technology. The book is comprised of 39 chapters that tackle a wide variety of concern in communications technology. The coverage of the text includes technologies, such as analog digital communications systems, radio frequency receiver, and satellite systems. The book also discusses some methods and techniques used in communications technology, including mixer signal processing, modulation and demodulation, and spread spectrum techniques. The text will be of great use to engineers, t

Petra Governance Handbook - WP7 – Governance structures & business models : D7.3: Governance Handbook

NARCIS (Netherlands)

Veeneman, W.; Hirschhorn, F.; Klievink, A.J.; Steenhuisen, B.M.; van der Voort, H.G.

2017-01-01

This document represents the governance handbook on mobility data platforms for the PETRA project. The governance handbook provides metropolitan authorities contemplating the implementation of a mobility data platform in line with the PETRA project about governance issues and design.
The

Handbook for value-impact assessment

International Nuclear Information System (INIS)

Heaberlin, S.W.; Burnham, J.B.; Gallucci, R.H.V.

1983-12-01

The basic purpose of this handbook is to document a set of systematic procedures for providing information that can be used in performing value-impact assessments of Nuclear Regulatory Commission (NRC) regulatory actions. The handbook describes a structured but flexible process for performing the assessment. Chapter 1 is an introduction to the value-impact assessment process. Chapter 2 describes the attributes most frequently affected by proposed NRC actions, provides guidance concerningthe appropriate level of effort to be devoted to the assessment, suggests a standard format for documenting the assessment, and discusses the treatment of uncertainty. Chapter 3 contains detailed methods for evaluating each of the attributes affected by a regulatory action. The handbook has five appendixes containing background information, technical data, and example applications of the value-impact assessment procedures. This edition of the handbook focuses primarily on assessing nuclear power reactor safety issues

WIPP Project Records Management Handbook

International Nuclear Information System (INIS)

1991-01-01

The Waste Isolation Pilot Plant (WIPP) Records Management Handbook provides the WIPP Project Records Management personnel with a tool to use to fulfill the requirements of the WIPP Records Program and direct their actions in the important area of records management. The handbook describes the various project areas involved in records management, and how they function. The handbook provides the requirements for Record Coordinators and Master Record Center (MRC) personnel to follow in the normal course of file management, records scheduling, records turnover, records disposition, and records retrieval. More importantly, the handbook provides a single reference which encompasses the procedures set fourth in DOE Order 1324.2A, ''Records Disposition'' ASME NQA-1, ''Quality Assurance Program Requirements for Nuclear Facilities'' and DOE-AL 5700.6B, ''General Operations Quality Assurance.'' These documents dictate how an efficient system of records management will be achieved on the WIPP Project

Instructional Improvement Listening Handbook. Secondary Level.

Science.gov (United States)

Crapse, Larry

Stressing that the importance of listening carefully cannot be underestimated, this handbook describes the process of listening (including the five components--previous knowledge, listening material, physiological activity, attention, and intellectual activity), some barriers to efficient listening, and bad and good listening habits. It also…

Guidelines for Guidelines: Are They Up to the Task? A Comparative Assessment of Clinical Practice Guideline Development Handbooks

Science.gov (United States)

Ansari, Shabnam; Rashidian, Arash

2012-01-01

Objectives We conducted a comparative review of clinical practice guideline development handbooks. We aimed to identify the main guideline development tasks, assign weights to the importance of each task using expert opinions and identify the handbooks that provided a comprehensive coverage of the tasks. Methods We systematically searched and included handbooks published (in English language) by national, international or professional bodies responsible for evidenced-based guideline development. We reviewed the handbooks to identify the main guideline development tasks and scored each handbook for each task from 0 (the handbook did not mention the task) to 2 (the task suitably addressed and explained), and calculated a weighted score for each handbook. The tasks included in over 75% of the handbooks were considered as ‘necessary’ tasks. Result Nineteen guideline development handbooks and twenty seven main tasks were identified. The guideline handbooks’ weighted scores ranged from 100 to 220. Four handbooks scored over 80% of the maximum possible score, developed by the National Institute for Health and Clinical Excellence, Swiss Centre for International Health, Scottish Intercollegiate Guidelines Network and World Health Organization. Necessary tasks were: selecting the guideline topic, determining the guideline scope, identifying relevant existing guidelines, involving the consumers, forming guideline development group,, developing clinical questions, systematic search for evidence, selecting relevant evidence, appraising identifies research evidence, making group decision, grading available evidence, creating recommendations, final stakeholder consultation, guideline implementation strategies, updating recommendations and correcting potential errors. Discussion Adequate details for evidence based development of guidelines were still lacking from many handbooks. The tasks relevant to ethical issues and piloting were missing in most handbooks. The findings

Low Complexity List Decoding for Polar Codes with Multiple CRC Codes

Directory of Open Access Journals (Sweden)

Jong-Hwan Kim

2017-04-01

Full Text Available Polar codes are the first family of error correcting codes that provably achieve the capacity of symmetric binary-input discrete memoryless channels with low complexity. Since the development of polar codes, there have been many studies to improve their finite-length performance. As a result, polar codes are now adopted as a channel code for the control channel of 5G new radio of the 3rd generation partnership project. However, the decoder implementation is one of the big practical problems and low complexity decoding has been studied. This paper addresses a low complexity successive cancellation list decoding for polar codes utilizing multiple cyclic redundancy check (CRC codes. While some research uses multiple CRC codes to reduce memory and time complexity, we consider the operational complexity of decoding, and reduce it by optimizing CRC positions in combination with a modified decoding operation. Resultingly, the proposed scheme obtains not only complexity reduction from early stopping of decoding, but also additional reduction from the reduced number of decoding paths.

EURANOS. Generic handbook for assisting in the management of contaminated inhabited areas in Europe following a radiological emergency

DEFF Research Database (Denmark)

Nisbet, A.F.; Andersson, Kasper Grann; Brown, J.

industry and others who may be affected. The handbook is a living document that requires updating from time to time to remain state-of-the-art and customisation of the generic handbook is an essential part of its use within individual countries. The handbook includes management options for application...... and plants; trees and shrubs. The handbook is divided into several independent sections comprising: supporting scientific and technical information; an analysis of the factors influencing recovery; compendia of comprehensive, state-of-the-art datasheets for more than 50 management options; guidance....... The handbook for inhabited areas complements the two other handbooks for food production systems and drinking water supplies....

Reference handbook: Level detectors

International Nuclear Information System (INIS)

1990-01-01

The purpose of this handbook is to provide Rocky Flats personnel with the information necessary to understand level measurement and detection. Upon completion of this handbook you should be able to do the following: List three reasons for measuring level. Describe the basic operating principles of the sight glass. Demonstrate proper techniques for reading a sight glass. Describe the basic operating principles of a float level detector. Describe the basic operating principles of a bubbler level indicating system. Explain the differences between a wet and dry reference leg indicating system, and describe how each functions. This handbook is designed for use by experienced Rocky Flats operators to reinforce and improve their current knowledge level, and by entry-level operators to ensure that they possess a minimum level of fundamental knowledge. Level Detectors is applicable to many job classifications and can be used as a reference for classroom work or for self-study. Although this reference handbook is by no means all-encompassing, you will gain enough information about this subject area to assist you in contributing to the safe operation of Rocky Flats Plant

Practical electronics handbook

CERN Document Server

Sinclair, Ian R

1988-01-01

Practical Electronics Handbook, Second Edition covers information useful in electronics, with focus on mathematical conventions. The handbook discusses the passive (resistors, capacitors, band coding, and inductors) and active discrete (diodes, transistors and negative feedback) components; discrete component circuits; and transferring digital data. Linear I.C.s, which are the single-chip arrangements of amplifier circuits that are intended to be biased and operated in a linear way, and digital I.C.s, which process signals and consist of two significant voltage levels, are also considered. T

Combination of preoperative NLR, PLR and CEA could increase the diagnostic efficacy for I-III stage CRC.

Science.gov (United States)

Peng, Hong-Xin; Yang, Lin; He, Bang-Shun; Pan, Yu-Qin; Ying, Hou-Qun; Sun, Hui-Ling; Lin, Kang; Hu, Xiu-Xiu; Xu, Tao; Wang, Shu-Kui

2017-09-01

Inflammation plays an important role in the development and progression of CRC. The members of inflammatory biomarkers, preoperative NLR and PLR, have been proved by numerous studies to be promising prognostic biomarkers for CRC. However, the diagnostic value of the two biomarkers in CRC remains unknown, and no study reported the combined diagnostic efficacy of NLR, PLR and CEA. Five hundred and fifty-nine patients with I-III stage CRC undergoing surgical resection and 559 gender- and age-matched healthy controls were enrolled in this retrospective study. NLR and PLR were calculated from preoperative peripheral blood cell count detected using white blood cell five classification by Sysmex XT-1800i Automated Hematology System and serum CEA were measured by electrochemiluminescence by ELECSYS 2010. The diagnostic performance of NLR, PLR and CEA for CRC was evaluated by ROC curve. Levels of NLR and PLR in the cases were significantly higher than them in the healthy controls. ROC curves comparison analyses showed that the diagnostic efficacy of NLR (AUC=.755, 95%CI=.728-.780) alone for CRC was significantly higher than PLR (AUC=.723, 95%CI=.696-.749, P=.037) and CEA (AUC=.690, 95%CI=.662-.717, P=.002) alone. In addition, the diagnostic efficacy of the combination of NLR, PLR and CEA(AUC=.831, 95%CI=.807-.852)for CRC was not only significantly higher than NLR alone but also higher than any combinations of the two of these three biomarkers (PCRC diagnostic biomarker, even for early stage CRC, and the combination of NLR, PLR and CEA could significantly improve the diagnostic efficacy. © 2016 Wiley Periodicals, Inc.

IRRIGATION PRACTICES IN LONG-TERM SURVIVORS OF COLORECTAL CANCER (CRC) WITH COLOSTOMIES

OpenAIRE

Grant, Marcia; McMullen, Carmit K.; Altschuler, Andrea; Hornbrook, Mark C.; Herrinton, Lisa J.; Wendel, Christopher S.; Baldwin, Carol M.; Krouse, Robert S.

2012-01-01

Creation of a colostomy in colorectal (CRC) cancer patients results in a loss of control over bowel evacuation. The only way to re-establish some control is through irrigation, a procedure that involves instilling fluid into the bowel to allow for gas and fecal output. This article reports on irrigation practices of participants in a large, multi-site, multi-investigator study of health-related quality of life (HR-QOL) in long term CRC survivors. Questions about irrigation practices were iden...

Handbook of infrared standards II with spectral coverage between

CERN Document Server

Meurant, Gerard

1993-01-01

This timely compilation of infrared standards has been developed for use by infrared researchers in chemistry, physics, engineering, astrophysics, and laser and atmospheric sciences. Providing maps of closely spaced molecular spectra along with their measured wavenumbers between 1.4vm and 4vm, this handbook will complement the 1986 Handbook of Infrared Standards that included special coverage between 3 and 2600vm. It will serve as a necessary reference for all researchers conducting spectroscopic investigations in the near-infrared region.Key Features:- Provides all new spec

Integrated Circuit Electromagnetic Immunity Handbook

Science.gov (United States)

Sketoe, J. G.

2000-08-01

This handbook presents the results of the Boeing Company effort for NASA under contract NAS8-98217. Immunity level data for certain integrated circuit parts are discussed herein, along with analytical techniques for applying the data to electronics systems. This handbook is built heavily on the one produced in the seventies by McDonnell Douglas Astronautics Company (MDAC, MDC Report E1929 of 1 August 1978, entitled Integrated Circuit Electromagnetic Susceptibility Handbook, known commonly as the ICES Handbook, which has served countless systems designers for over 20 years). Sections 2 and 3 supplement the device susceptibility data presented in section 4 by presenting information on related material required to use the IC susceptibility information. Section 2 concerns itself with electromagnetic susceptibility analysis and serves as a guide in using the information contained in the rest of the handbook. A suggested system hardening requirements is presented in this chapter. Section 3 briefly discusses coupling and shielding considerations. For conservatism and simplicity, a worst case approach is advocated to determine the maximum amount of RF power picked up from a given field. This handbook expands the scope of the immunity data in this Handbook is to of 10 MHz to 10 GHz. However, the analytical techniques provided are applicable to much higher frequencies as well. It is expected however, that the upper frequency limit of concern is near 10 GHz. This is due to two factors; the pickup of microwave energy on system cables and wiring falls off as the square of the wavelength, and component response falls off at a rapid rate due to the effects of parasitic shunt paths for the RF energy. It should be noted also that the pickup on wires and cables does not approach infinity as the frequency decreases (as would be expected by extrapolating the square law dependence of the high frequency roll-off to lower frequencies) but levels off due to mismatch effects.

The SQUID Handbook

CERN Document Server

Braginski, Alex I

2006-01-01

This two-volume handbook offers a comprehensive and well coordinated presentation of SQUIDs (Superconducting Quantum Interference Devices), including device fundamentals, design, technology, system construction and multiple applications. It is intended to bridge the gap between fundamentals and applications, and will be a valuable textbook reference for graduate students and for professionals engaged in SQUID research and engineering. It will also be of use to specialists in multiple fields of practical SQUID applications, from human brain research and heart diagnostics to airplane and nuclear

REA's handbook of English grammar, style, and writing

CERN Document Server

REA, The Editors of

1992-01-01

The ability to write and speak correctly and effectively is a prerequisite for doing well in all subjects, including the physical and social sciences, math and the liberal arts. Writing and speaking skills become even more important when seeking a job and trying to succeed in a chosen career. This easy-to-understand, straightforward English handbook does not use the hard-to-understand technical jargon usually found in English grammar books. Instead, this handbook provides hundreds of examples from which it is possible to easily see what is correct and what is incorrect in all areas of English grammar and writing. Learn quickly and easily: 1. Rules and exceptions in grammar, 2. Spelling and proper punctuation, 3. Common errors in sentence structure, 4. 2,000 examples of correct usage, and 5. Effective writing skills. Complete practice exercises with answers follow each chapter.The handbook covers the following in detail: nouns, verbs, adjectives, paragraphs, composition, punctuation, spelling, and much more. A...

The Java EE architect's handbook how to be a successful application architect for Java EE applications

CERN Document Server

Ashmore, Derek C.

2014-01-01

This handbook is a concise guide to assuming the role of application architect for Java EE applications. This handbook will guide the application architect through the entire Java EE project including identifying business requirements, performing use-case analysis, object and data modeling, and guiding a development team during construction. This handbook will provide tips and techniques for communicating with project managers and management. This handbook will provide strategies for making your application easier and less costly to support. Whether you are about to architect your first Java EE application or are looking for ways to keep your projects on-time and on-budget, you will refer to this handbook again and again.

Influence of the Crc regulator on the hierarchical use of carbon sources from a complete medium in Pseudomonas.

Science.gov (United States)

La Rosa, Ruggero; Behrends, Volker; Williams, Huw D; Bundy, Jacob G; Rojo, Fernando

2016-03-01

The Crc protein, together with the Hfq protein, participates in catabolite repression in pseudomonads, helping to coordinate metabolism. Little is known about how Crc affects the hierarchy of metabolite assimilation from complex mixtures. Using proton Nuclear Magnetic Resonance (NMR) spectroscopy, we carried out comprehensive metabolite profiling of culture supernatants (metabolic footprinting) over the course of growth of both Pseudomonas putida and P. aeruginosa, and compared the wild-type strains with deletion mutants for crc. A complex metabolite consumption hierarchy was observed, which was broadly similar between the two species, although with some important differences, for example in sugar utilization. The order of metabolite utilization changed upon inactivation of the crc gene, but even in the Crc-null strains some compounds were completely consumed before late metabolites were taken up. This suggests the presence of additional regulatory elements that determine the time and order of consumption of compounds. Unexpectedly, the loss of Crc led both species to excrete acetate and pyruvate as a result of unbalanced growth during exponential phase, compounds that were later consumed in stationary phase. This loss of carbon during growth helps to explain the contribution of the Crc/Hfq regulatory system to evolutionary fitness of pseudomonads. © 2015 Society for Applied Microbiology and John Wiley & Sons Ltd.

NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.

Science.gov (United States)

Narayan, Satya; Jaiswal, Aruna S; Sharma, Ritika; Nawab, Akbar; Duckworth, Lizette Vila; Law, Brian K; Zajac-Kaye, Maria; George, Thomas J; Sharma, Jay; Sharma, Arun K; Hromas, Robert A

2017-08-22

The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. These stalled replication forks then collapse to form one sided double-strand breaks, leading to apoptosis. However, colorectal cancer (CRC) stem cells rapidly repair the stalled/collapsed replication forks and overcome treatment effects. Recent evidence suggests a critical role of checkpoint kinase 1 (Chk1) in preventing the replicative stress. Therefore, Chk1 kinase has been a target for developing mono or combination therapeutic agents. In the present study, we have identified a novel orphan molecule NSC30049 (NSC49L) that is effective alone, and in combination potentiates 5-FU-mediated growth inhibition of CRC heterogeneous bulk and FOLFOX-resistant cell lines in culture with minimal effect on normal colonic epithelial cells. It also inhibits the sphere forming activity of CRC stem cells, and decreases the expression levels of mRNAs of CRC stem cell marker genes. Results showed that NSC49L induces 5-FU-mediated S-phase cell cycle arrest due to increased load of DNA damage and increased γ-H2AX staining as a mechanism of cytotoxicity. The pharmacokinetic analysis showed a higher bioavailability of this compound, however, with a short plasma half-life. The drug is highly tolerated by animals with no pathological aberrations. Furthermore, NSC49L showed very potent activity in a HDTX model of CRC stem cell tumors either alone or in combination with 5-FU. Thus, NSC49L as a single agent or combined with 5-FU can be developed as a therapeutic agent by targeting the Chk1 pathway in 5-FU-resistant CRC heterogeneous bulk and CRC stem cell populations.

An investigation on microwave sintering of Fe, Fe–Cu and Fe–Cu–C ...

Indian Academy of Sciences (India)

The current study examines the effect of heating mode on densifi- cation, microstructure ..... ing mechanisms. It increases the self diffusion coefficient of .... Lide D R (ed) 1998 CRC handbook of chemistry and physics (Boca. Raton, FL: CRC ... MPIF Standard 46 1991 Determination of tap density of metal powder. Standard ...

Handbook of wafer bonding

CERN Document Server

Ramm, Peter; Taklo, Maaike M V

2011-01-01

Written by an author and editor team from microsystems companies and industry-near research organizations, this handbook and reference presents dependable, first-hand information on bonding technologies.In the first part, researchers from companies and institutions around the world discuss the most reliable and reproducible technologies for the production of bonded wafers. The second part is devoted to current and emerging applications, including microresonators, biosensors and precise measuring devices.

Handbook of radioimmunoassay

International Nuclear Information System (INIS)

Abraham, G.E.

1977-01-01

This handbook provides clear, detailed descriptions of ways to set up radioimmunoassay procedures for a variety of polypeptides and low molecular weight compounds. It covers extensively the subjects of statistical evaluation of radioimmunoassay, instrumentation in radioimmunoassay, and radiation safety in the performance of radioimmunoassay. Related nonconventional methods are also discussed. Contributors to this handbook have presented their own procedures for performing the radioimmunoassay and their rationale for choosing particular reagents and conditions. Emphasis is on providing sufficient information to enable relatively inexperienced immunoassayists to set up assay systems with a minimum of difficulty

The small library manager's handbook

CERN Document Server

Graves, Alice

2014-01-01

The Small Library Manager's Handbook is for librarians working in all types of small libraries. It covers the everyday nuts-and-bolts operations that all librarians must perform. This handbook, written by experts who are small librarians themselves, will help all small librarians to do multiple jobs at the same time.

Handbook for TEAC Auditors, 2011

Science.gov (United States)

Teacher Education Accreditation Council, 2011

2011-01-01

This handbook is primarily for the Teacher Education Accreditation Council (TEAC) auditor. It is intended to help in preparing for audits of "Inquiry Briefs" and "Inquiry Brief Proposals" and to contribute to the writing of the audit report. This handbook contains a full description of the audit process, the responsibilities of…

Handbook of Technical Communication

OpenAIRE

Mehler , Alexander; Romary , Laurent; Gibbon , Dafydd

2012-01-01

International audience; The handbook "Technical Communication" brings together a variety of topics which range from the role of technical media in human communication to the linguistic, multimodal enhancement of present-day technologies. It covers the area of computer-mediated text, voice and multimedia communication as well as of technical documentation. In doing so, the handbook takes professional and private communication into account. Special emphasis is put on technical communication bas...

The handbook of journal publishing

CERN Document Server

Morris, Sally; LaFrenier, Douglas; Reich, Margaret

2013-01-01

The Handbook of Journal Publishing is a comprehensive reference work written by experienced professionals, covering all aspects of journal publishing, both online and in print. Journals are crucial to scholarly communication, but changes in recent years in the way journals are produced, financed, and used make this an especially turbulent and challenging time for journal publishers - and for authors, readers, and librarians. The Handbook offers a thorough guide to the journal publishing process, from editing and production through marketing, sales, and fulfilment, with chapters on management, finances, metrics, copyright, and ethical issues. It provides a wealth of practical tools, including checklists, sample documents, worked examples, alternative scenarios, and extensive lists of resources, which readers can use in their day-to-day work. Between them, the authors have been involved in every aspect of journal publishing over several decades and bring to the text their experience working for a wide range of ...

Structural stability, electronic, mechanical and superconducting properties of CrC and MoC

Energy Technology Data Exchange (ETDEWEB)

Kavitha, M.; Sudha Priyanga, G. [Department of Physics, N.M.S.S.V.N College, Madurai 625019, Tamilnadu (India); Rajeswarapalanichamy, R., E-mail: rrpalanichamy@gmail.com [Department of Physics, N.M.S.S.V.N College, Madurai 625019, Tamilnadu (India); Iyakutti, K. [Department of Physics and Nanotechnology, SRM University, Chennai 603203, Tamilnadu (India)

2016-02-01

The structural, electronic, mechanical and superconducting properties of chromium carbide (CrC) and molybdenum carbide (MoC) are investigated using first principles calculations based on density functional theory (DFT). The computed ground state properties like equilibrium lattice constants and cell volume are in good agreement with available theoretical and experimental data. A pressure induced structural phase transition from tungsten carbide phase (WC) to zinc blende phase (ZB) and then zinc blende phase (ZB) to nickel arsenide phase (NiAs) are observed in both chromium and molybdenum carbides. Electronic structure reveals that these carbides are metallic at ambient condition. All the calculated elastic constants obey the Born–Huang stability criteria, suggesting that they are mechanically stable at normal and high pressure. The super conducting transition temperatures for CrC and MoC in WC phase are found to be 31.12 K and 17.14 K respectively at normal pressure. - Highlights: • Electronic and mechanical properties of CrC and MoC are investigated. • Pressure induced structural phase transition is predicted at high pressure. • Electronic structure reveals that these materials exhibit metallic behaviour. • Debye temperature values are computed for CrC and MoC. • Superconducting transition temperature values are computed.

Handbook of the Economics of Education. Volume 2

Science.gov (United States)

Hanushek, Erik A., Ed.; Welch, F., Ed.

2006-01-01

The Handbooks in Economics series continues to provide the various branches of economics with handbooks which are definitive reference sources, suitable for use by professional researchers, advanced graduate students, or by those seeking a teaching supplement. With contributions from leading researchers, each Handbook presents an accurate,…

Handbook of mathematics

CERN Document Server

Kuipers, L

1969-01-01

International Series of Monographs in Pure and Applied Mathematics, Volume 99: Handbook of Mathematics provides the fundamental mathematical knowledge needed for scientific and technological research. The book starts with the history of mathematics and the number systems. The text then progresses to discussions of linear algebra and analytical geometry including polar theories of conic sections and quadratic surfaces. The book then explains differential and integral calculus, covering topics, such as algebra of limits, the concept of continuity, the theorem of continuous functions (with examp

Handbook of thermoluminescence

CERN Document Server

Furetta, Claudio

2010-01-01

This second edition of the Handbook of Thermoluminescence enlarges on all the subjects which were treated in the first edition and adds further arguments, including the theory of thermoluminescent dose measurement, several examples concerning the kinetics parameters determination using various methods such as peak shape, isothermal decay, and so on. A special section is devoted to food irradiation, an important subject at the present time, and to the thermoluminescent characterization of the minerals extracted from the irradiated food. Another new section is devoted to the thermoluminescent ph

Leybold vacuum handbook

CERN Document Server

Diels, K; Diels, Kurt

1966-01-01

Leybold Vacuum Handbook presents a collection of data sets that are essential for numerical calculation of vacuum plants and vacuum processes. The title first covers vacuum physics, which includes gas kinetics, flow phenomena, vacuum gauges, and vapor removal. Next, the selection presents data on vacuum, high vacuum process technology, and gas desorption and gettering. The text also deals with materials, vapor pressure, boiling and melting points, and gas permeability. The book will be of great interest to engineers and technicians that deals with vacuum related technologies.

Springer handbook of acoustics

CERN Document Server

2014-01-01

Acoustics, the science of sound, has developed into a broad interdisciplinary field encompassing the academic disciplines of physics, engineering, psychology, speech, audiology, music, architecture, physiology, neuroscience, and electronics. The Springer Handbook of Acoustics is also in his 2nd edition an unparalleled modern handbook reflecting this richly interdisciplinary nature edited by one of the acknowledged masters in the field, Thomas Rossing. Researchers and students benefit from the comprehensive contents. This new edition of the Handbook features over 11 revised and expanded chapters, new illustrations, and 2 new chapters covering microphone arrays  and acoustic emission.  Updated chapters contain the latest research and applications in, e.g. sound propagation in the atmosphere, nonlinear acoustics in fluids, building and concert hall acoustics, signal processing, psychoacoustics, computer music, animal bioacousics, sound intensity, modal acoustics as well as new chapters on microphone arrays an...

Handbook of co₂ in power systems

CERN Document Server

Rebennack, Steffen; Pardalos, Panos; Pereira, Mario; Iliadis, Niko

2012-01-01

The Handbook of CO₂in Power Systems' objective is to include the state-of-the-art developments that occurred in power systems taking CO₂emission into account. The book includes power systems operation modeling with CO₂emissions considerations, CO₂market mechanism modeling, CO₂regulation policy modeling, carbon price forecasting, and carbon capture modeling. For each of the subjects, at least one article authored by a world specialist on the specific domain is included.

Handbook of nuclear safeguards measurement methods

International Nuclear Information System (INIS)

Rogers, D.R.

1983-09-01

This handbook is intended to be a guide to the selection of methods for meeting specific measurement requirements. The information was compiled from a survey of production facilities, the literature, and current exchange programs. The survey included bulk measurements, chemical assay, sampling techniques, isotopic measurements, passive NDA, and active NDA

Handbook for nuclear power plant self-assessment programs. Final report, July 1991

International Nuclear Information System (INIS)

1991-07-01

EPRI has prepared this handbook to help utilities with their Self-Assessment Programs at nuclear power plants. Self-assessments are independent reviews performed by nuclear plant utilities to identify trends in operational activities that are important to safety, and to assess the impact of these trends on plant safety. Activities performed as self-assessments include reviews and evaluations of plant performance and abnormal events, technical evaluations of plant activities to identify potential problem areas, and reviews of other sources of plant design and operating experience for applicability to safety. This handbook is based on information obtained from utilities and includes examples of activities and methods that have proven effective. The handbook includes a summary of NRC requirements, guidelines for self-assessment program planning, descriptions and examples of investigative techniques, and key references that can be consulted for additional information. It can serve as a training guide for plant staff members who are assigned to self-assessment activities. (author)

Multicenter retrospective analysis of metastatic colorectal cancer (CRC) with high-level microsatellite instability (MSI-H).

Science.gov (United States)

Goldstein, J; Tran, B; Ensor, J; Gibbs, P; Wong, H L; Wong, S F; Vilar, E; Tie, J; Broaddus, R; Kopetz, S; Desai, J; Overman, M J

2014-05-01

The microsatellite instability-high (MSI-H) phenotype, present in 15% of early colorectal cancer (CRC), confers good prognosis. MSI-H metastatic CRC is rare and its impact on outcomes is unknown. We describe survival outcomes and the impact of chemotherapy, metastatectomy, and BRAF V600E mutation status in the largest reported cohort of MSI-H metastatic colorectal cancer (CRC). A retrospective review of 55 MSI-H metastatic CRC patients from two institutions, Royal Melbourne Hospital (Australia) and The University of Texas MD Anderson Cancer Center (United States), was conducted. Statistical analyses utilized Kaplan-Meier method, Log-rank test, and Cox proportional hazards models. Median age was 67 years (20-90), 58% had poor differentiation, and 45% had stage IV disease at presentation. Median overall survival (OS) from metastatic disease was 15.4 months. Thirteen patients underwent R0/R1 metastatectomies, with median OS from metastatectomy 33.8 months. Thirty-one patients received first-line systemic chemotherapy for metastatic disease with median OS from the start of chemotherapy 11.5 months. No statistically significant difference in progression-free survival or OS was seen between fluoropyrimidine, oxaliplatin, or irinotecan based chemotherapy. BRAF V600E mutation was present in 14 of 47 patients (30%). BRAF V600E patients demonstrated significantly worse median OS; 10.1 versus 17.3 months, P = 0.03. In multivariate analyses, BRAF V600E mutants had worse OS (HR 4.04; P = 0.005), while patients undergoing metastatectomy (HR 0.11; P = CRC do not appear to have improved outcomes. BRAF V600E mutation is a poor prognostic factor in MSI-H metastatic CRC.

Services Subcontract Technical Representative (STR) handbook

International Nuclear Information System (INIS)

Houston, D.H.

1997-06-01

The purpose of this handbook is to provide guidance to Bechtel Hanford, Inc. Subcontract Representatives in their assignments. It is the intention of this handbook to ensure that subcontract work is performed in accordance with the subcontract documents

Human-computer interaction handbook fundamentals, evolving technologies and emerging applications

CERN Document Server

Sears, Andrew

2007-01-01

This second edition of The Human-Computer Interaction Handbook provides an updated, comprehensive overview of the most important research in the field, including insights that are directly applicable throughout the process of developing effective interactive information technologies. It features cutting-edge advances to the scientific knowledge base, as well as visionary perspectives and developments that fundamentally transform the way in which researchers and practitioners view the discipline. As the seminal volume of HCI research and practice, The Human-Computer Interaction Handbook feature

Radio Wave Propagation Handbook for Communication on and Around Mars

Science.gov (United States)

Ho, Christian; Golshan, Nasser; Kliore, Arvydas

2002-01-01

This handbook examines the effects of the Martian environment on radio wave propagation on Mars and in the space near the planet. The environmental effects include these from the Martian atmosphere, ionosphere, global dust storms, aerosols, clouds, and geomorphologic features. Relevant Martian environmental parameters were extracted from the measurements of Mars missions during the past 30 years, especially from Mars Pathfinder and Mars Global Surveyor. The results derived from measurements and analyses have been reviewed through an extensive literature search. The updated parameters have been theoretically analyzed to study their effects on radio propagation. This handbook also provides basic information about the entire telecommunications environment on and around Mars for propagation researchers, system engineers, and link analysts. Based on these original analyses, some important recommendations have been made, including the use of the Martian ionosphere as a reflector for Mars global or trans-horizon communication between future Martian colonies, reducing dust storm scattering effects, etc. These results have extended our wave propagation knowledge to a planet other than Earth; and the tables, models, and graphics included in this handbook will benefit telecommunication system engineers and scientific researchers.

Welding engineering handbook. Volume 1

International Nuclear Information System (INIS)

Sundarrajan, S.; Bhaskar, S.V.; Amarnath Kumar, G.C.

1992-11-01

In this Welding Engineering Handbook, we have brought key application areas of welding which are of technocommercial importance. These details are not normally available. Each author, highly specialized in these areas has spent considerable amount of time and covered the topic exhaustively giving valuable details. Each application area has different quality requirements which are brought out clearly. This handbook is designed to cater the information source for various professionals in core sector industries like fabrication, shipbuilding, automobiles, nuclear plants, machine building, fertilisers and chemical industry, pressure vessel manufactures etc. We are sure that this handbook will serve as a reference reckoner to all plant/works managers, maintenance, projects, engineers, R and D and students. (original)

HANDBOOK ON ADVANCED PHOTOCHEMICAL OXIDATION ...

Science.gov (United States)

This handbook summarizes commercial-scale system performance and cost data for advanced photochemical oxidation (APO) treatment of contaminated water, air, and solids. Similar information from pilot- and bench-scale evaluations of APO processes is also included to supplement the commercial-scale data. Performance and cost data is summarized for various APO processes, including vacuum ultraviolet (VUV) photolysis, ultraviolet (UV)/oxidation, photo-Fenton, and dye- or semiconductor-sensitized APO processes. This handbook is intended to assist engineering practitioners in evaluating the applicability of APO processes and in selecting one or more such processes for site-specific evaluation.APO has been shown to be effective in treating contaminated water and air. Regarding contaminated water treatment, UV/oxidation has been evaluated for the most contaminants, while VUV photolysis has been evaluated for the fewest. Regarding contaminated air treatment, the sensitized APO processes have been evaluated for the most contaminants, while VUV photolysis has been evaluated for the fewest.APO processes for treating contaminated solids generally involve treatment of contaminated slurry or leachate generated using an extraction process such as soil washing. APO has been shown to be effective in treating contaminated solids, primarily at the bench-scale level. Information

DOE handbook electrical safety

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-01-01

Electrical Safety Handbook presents the Department of Energy (DOE) safety standards for DOE field offices or facilities involved in the use of electrical energy. It has been prepared to provide a uniform set of electrical safety guidance and information for DOE installations to effect a reduction or elimination of risks associated with the use of electrical energy. The objectives of this handbook are to enhance electrical safety awareness and mitigate electrical hazards to employees, the public, and the environment.

Handbook of Social Capital

DEFF Research Database (Denmark)

The Handbook of Social Capital balances the ‘troika' of sociology, political science and economics by offering important contributions to the study of bonding and bridging social capital networks. This inter-disciplinary Handbook intends to serve as a bridge for students and scholars within all...... the social sciences. The contributors explore the different scientific approaches that are all needed if international research is to embrace both the bright and the more shadowy aspects of social capital....

Soviet Space Program Handbook.

Science.gov (United States)

1988-04-01

in advance and some events were even broadcast live. Immediately following the first success- ful launch of their new Energia space launch vehicle in...early 1988. Just as a handbook written a couple of years ago would need updating with Mir, Energia , and the SL-16, this handbook will one day need up...1986. Johnson, Nicholas L. The Soviet Year in Space 1983. Colorado Springs, CO: Teledyne Brown Engineering, 1984. Lawton, A. " Energia - Soviet Super

Handbook for Greenhouse Rose Production Ethiopia

NARCIS (Netherlands)

Maden, van der E.; Hoogerwerf, F.; Marrewijk, van J.; Kerklaan, E.; Posthumus, J.; Boven, van A.; Elings, A.; Garcia Victoria, N.; Rikken, M.; Humphries, G.

2012-01-01

This practical handbook is prepared by DLV Plant, in collaboration with Wageningen UR, CBI and EHPEA, under assignment of the Ethiopia Netherlands Horticulture Partnership (ENHP). The following persons have contributed to this handbook: DVL Plant: Edwin van der Maden, Francis Hoogerwerf, Jeroen van

Handbook for value-impact assessments of NRC regulatory actions

International Nuclear Information System (INIS)

Mullen, M.F.; DiPalo, A.J.

1985-01-01

According to current Nuclear Regulatory Commission (NRC) procedures, value-impact (cost-benefit) assessments must be prepared for all rulemaking actions and for a broad range of other regulatory requirements and guidance. Probabilistic risk assessment (PRA) methods furnish an important part of the information base for these assessments. PRA methods are frequently the principal quantitative tool for estimating the benefits (e.g., public risk reduction) of proposed regulatory actions. In December 1983, the NRC published A Handbook for Value-Impact Assessment, NUREG/CR-3568, which provides a set of systematic procedures for performing value-impact assessments. The Handbook contains methods, data, and sources of information that can assist the regulatory analyst in conducting such assessments. The use of probabilistic risk analysis to estimate the benefits of proposed regulatory actions is described. Procedures and methods are also given for evaluating the costs and other consequences associated with regulatory actions. The Handbook has been adopted by the NRC as the recommended guideline for value impact assessments. This paper presents the background, objectives, and scope of the Handbook, describes the value-impact assessment methods (including the use of probabilistic risk assessment to estimate benefits), and discusses a selection of current and planned applications, with examples to illustrate how the methods are used

Geothermal survey handbook

Energy Technology Data Exchange (ETDEWEB)

1974-01-01

The objective of this handbook is to publicize widely the nature of geothermal surveys. It covers geothermal survey planning and measurement as well as measurement of thermal conductivity. Methods for the detection of eruptive areas, the measurement of radiative heat using snowfall, the measurement of surface temperature using infrared radiation and the measurement of thermal flow are described. The book also contains information on physical detection of geothermal reservoirs, the measurement of spring wells, thermographic measurement of surface heat, irregular layer surveying, air thermographics and aerial photography. Isotope measurement techniques are included.

Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24.

Science.gov (United States)

Ishimaru, Shinya; Mimori, Koshi; Yamamoto, Ken; Inoue, Hiroshi; Imoto, Seiya; Kawano, Shuichi; Yamaguchi, Rui; Sato, Tetsuya; Toh, Hiroyuki; Iinuma, Hisae; Maeda, Toyoki; Ishii, Hideshi; Suzuki, Sadao; Tokudome, Shinkan; Watanabe, Masahiko; Tanaka, Jun-ichi; Kudo, Shin-ei; Sugihara, Ken-ichi; Hase, Kazuo; Mochizuki, Hidetaka; Kusunoki, Masato; Yamada, Kazutaka; Shimada, Yasuhiro; Moriya, Yoshihiro; Barnard, Graham F; Miyano, Satoru; Mori, Masaki

2012-09-01

Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated. A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures. Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulin-dependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM. We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.

Handbook on modelling for discrete optimization

CERN Document Server

Pitsoulis, Leonidas; Williams, H

2006-01-01

The primary objective underlying the Handbook on Modelling for Discrete Optimization is to demonstrate and detail the pervasive nature of Discrete Optimization. While its applications cut across an incredibly wide range of activities, many of the applications are only known to specialists. It is the aim of this handbook to correct this. It has long been recognized that "modelling" is a critically important mathematical activity in designing algorithms for solving these discrete optimization problems. Nevertheless solving the resultant models is also often far from straightforward. In recent years it has become possible to solve many large-scale discrete optimization problems. However, some problems remain a challenge, even though advances in mathematical methods, hardware, and software technology have pushed the frontiers forward. This handbook couples the difficult, critical-thinking aspects of mathematical modeling with the hot area of discrete optimization. It will be done in an academic handbook treatment...

CRC Handbook of Medical Physics, vol. 3

International Nuclear Information System (INIS)

Waggener, R.G.; Kereiakes, J.G.; Shalek, R.J.

1984-01-01

In this work, the care and testing of measurement and diagnostic instruments are described in detail. Difficulties encountered with therapeutic and diagnostic calibrations are explored and solutions are suggested. VOLUME III Physics Teaching for Radiologic Technologists, Physics Teaching for Diagnostic Radiology Residents, Physics Teaching for Nuclear Medicine Residents, Physics Teaching for Radiotherapy Residents, Degree Programs in Medical Physics, Radiobiology Teaching, Non-Degree Medical Physics Training and American Board of Radiology Certifications, Radioactivity and Production of Medical Isotopes, Practical Medical Physics Consulting, Radiologic Terminology, Nuclear Medicine Imaging Techniques, Description of Radiotherapy Procedures, Medical Applications of Ultrasonography and Thermography, Glossary of Medical and Anatomical Terms Used in Medical Physics, Equipment List for Medical Physics and Acquisition Priority. Bibliography of Reference Materials. Index

International Reactor Physics Handbook Database and Analysis Tool (IDAT) - IDAT user manual

International Nuclear Information System (INIS)

2013-01-01

The IRPhEP Database and Analysis Tool (IDAT) was first released in 2013 and is included on the DVD. This database and corresponding user interface allows easy access to handbook information. Selected information from each configuration was entered into IDAT, such as the measurements performed, benchmark values, calculated values and materials specifications of the benchmark. In many cases this is supplemented with calculated data such as neutron balance data, spectra data, k-eff nuclear data sensitivities, and spatial reaction rate plots. IDAT accomplishes two main objectives: 1. Allow users to search the handbook for experimental configurations that satisfy their input criteria. 2. Allow users to trend results and identify suitable benchmarks experiments for their application. IDAT provides the user with access to several categories of calculated data, including: - 1-group neutron balance data for each configuration with individual isotope contributions in the reactor system. - Flux and other reaction rates spectra in a 299-group energy scheme. Plotting capabilities were implemented into IDAT allowing the user to compare the spectra of selected configurations in the original fine energy structure or on any user-defined broader energy structure. - Sensitivity coefficients (percent changes of k-effective due to elementary change of basic nuclear data) for the major nuclides and nuclear processes in a 238-group energy structure. IDAT is actively being developed. Those approved to access the online version of the handbook will also have access to an online version of IDAT. As May 2013 marks the first release, IDAT may contain data entry errors and omissions. The handbook remains the primary source of reactor physics benchmark data. A copy of IDAT user's manual is attached to this document. A copy of the IRPhE Handbook can be obtained on request at http://www.oecd-nea.org/science/wprs/irphe/irphe-handbook/form.html

Enforcement handbook: Enforcement of DOE nuclear safety requirements

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-06-01

This Handbook provides detailed guidance and procedures to implement the General Statement of DOE Enforcement Policy (Enforcement Policy or Policy). A copy of this Enforcement Policy is included for ready reference in Appendix D. The guidance provided in this Handbook is qualified, however, by the admonishment to exercise discretion in determining the proper disposition of each potential enforcement action. As discussed in subsequent chapters, the Enforcement and Investigation Staff will apply a number of factors in assessing each potential enforcement situation. Enforcement sanctions are imposed in accordance with the Enforcement Policy for the purpose of promoting public and worker health and safety in the performance of activities at DOE facilities by DOE contractors (and their subcontractors and suppliers) who are indemnified under the Price-Anderson Amendments Act. These indemnified contractors, and their suppliers and subcontractors, will be referred to in this Handbook collectively as DOE contractors. It should be remembered that the purpose of the Department`s enforcement policy is to improve nuclear safety for the workers and the public, and this goal should be the prime consideration in exercising enforcement discretion.

Enforcement handbook: Enforcement of DOE nuclear safety requirements

International Nuclear Information System (INIS)

1995-06-01

This Handbook provides detailed guidance and procedures to implement the General Statement of DOE Enforcement Policy (Enforcement Policy or Policy). A copy of this Enforcement Policy is included for ready reference in Appendix D. The guidance provided in this Handbook is qualified, however, by the admonishment to exercise discretion in determining the proper disposition of each potential enforcement action. As discussed in subsequent chapters, the Enforcement and Investigation Staff will apply a number of factors in assessing each potential enforcement situation. Enforcement sanctions are imposed in accordance with the Enforcement Policy for the purpose of promoting public and worker health and safety in the performance of activities at DOE facilities by DOE contractors (and their subcontractors and suppliers) who are indemnified under the Price-Anderson Amendments Act. These indemnified contractors, and their suppliers and subcontractors, will be referred to in this Handbook collectively as DOE contractors. It should be remembered that the purpose of the Department's enforcement policy is to improve nuclear safety for the workers and the public, and this goal should be the prime consideration in exercising enforcement discretion

Information security employee handbook: November 2010

OpenAIRE

2013-01-01

This handbook is a quick reference guide to some of the most important points of the London 2012 information security policy. This information security handbook outlines the policies that all staff, secondees, volunteers and certain third parties who process LOCOG information must comply with.

Conditionally reprogrammed cells (CRC) methodology does not allow the in vitro expansion of patient-derived primary and metastatic lung cancer cells.

Science.gov (United States)

Sette, Giovanni; Salvati, Valentina; Giordani, Ilenia; Pilozzi, Emanuela; Quacquarini, Denise; Duranti, Enrico; De Nicola, Francesca; Pallocca, Matteo; Fanciulli, Maurizio; Falchi, Mario; Pallini, Roberto; De Maria, Ruggero; Eramo, Adriana

2018-07-01

Availability of tumor and non-tumor patient-derived models would promote the development of more effective therapeutics for non-small cell lung cancer (NSCLC). Recently, conditionally reprogrammed cells (CRC) methodology demonstrated exceptional potential for the expansion of epithelial cells from patient tissues. However, the possibility to expand patient-derived lung cancer cells using CRC protocols is controversial. Here, we used CRC approach to expand cells from non-tumoral and tumor biopsies of patients with primary or metastatic NSCLC as well as pulmonary metastases of colorectal or breast cancers. CRC cultures were obtained from both tumor and non-malignant tissues with extraordinary high efficiency. Tumor cells were tracked in vitro through tumorigenicity assay, monitoring of tumor-specific genetic alterations and marker expression. Cultures were composed of EpCAM+ lung epithelial cells lacking tumorigenic potential. NSCLC biopsies-derived cultures rapidly lost patient-specific genetic mutations or tumor antigens. Similarly, pulmonary metastases of colon or breast cancer generated CRC cultures of lung epithelial cells. All CRC cultures examined displayed epithelial lung stem cell phenotype and function. In contrast, brain metastatic lung cancer biopsies failed to generate CRC cultures. In conclusion, patient-derived primary and metastatic lung cancer cells were negatively selected under CRC conditions, limiting the expansion to non-malignant lung epithelial stem cells from either tumor or non-tumor tissue sources. Thus, CRC approach cannot be applied for direct therapeutic testing of patient lung tumor cells, as the tumor-derived CRC cultures are composed of (non-tumoral) airway basal cells. © 2018 UICC.

International handbook of evaluated criticality safety benchmark experiments

International Nuclear Information System (INIS)

2010-01-01

added to this document periodically. The document is organized in a manner that allows easy inclusion of additional evaluations as they become available. This handbook was prepared by a technical review group comprised of experienced criticality safety personnel from the United States, United Kingdom, Japan, the Russian Federation, France, Hungary, Republic of Korea, Slovenia, Serbia, Kazakhstan, Israel, Spain, Brazil, Czech Republic, Poland, India, Canada, China, Sweden, and Argentina. The ICSBEP Handbook is available both on DVD and the Internet. A 'Database for the International Criticality Safety Benchmark Evaluation Project' (DICE) is included on the DVD version of the Handbook. DICE is a tool intended to make more efficient use of the Handbook and will enable users to more easily identify information in the Handbook that meets their needs. Basically, DICE is a relational database with a user interface to query the database. DICE accomplishes two main objectives: - Provide a summary description of each experimental configuration, where the main characteristics of the experiments are displayed in a uniform format. - Allow users to search the handbook for experimental configurations that satisfy their unique input criteria (much more than a word search). DICE can facilitate finding desired benchmarks in the Handbook; however it is subject to data entry errors and omissions. The International Handbook remains the primary source of criticality safety benchmark data

EURANOS. Generic handbook for assisting in the management of contaminated food production systems in Europe following a radiological emergency

DEFF Research Database (Denmark)

Nisbet, A.F.; Howard, B.J.; Jones, A.

production sectors and others who may be affected. The handbook is a living document that requires updating from time to time to remain state-of-the-art and customisation of the generic handbook is an essential part of its use within individual countries. The handbook includes management options......The handbook for food production systems has been developed as a result of a series of UK and European initiatives involving a wide range of stakeholders. It is aimed at national and local authorities, central government departments and agencies, radiation protection experts, agriculture and food...... for application in the pre-release, emergency and longer term phases of an incident. Sources of contamination considered in the handbook are nuclear accidents, radiological dispersion devices and satellite accidents. Agricultural and domestic food production systems are considered, including the gathering of free...

Handbook of networking & connectivity

CERN Document Server

McClain, Gary R

1994-01-01

Handbook of Networking & Connectivity focuses on connectivity standards in use, including hardware and software options. The book serves as a guide for solving specific problems that arise in designing and maintaining organizational networks.The selection first tackles open systems interconnection, guide to digital communications, and implementing TCP/IP in an SNA environment. Discussions focus on elimination of the SNA backbone, routing SNA over internets, connectionless versus connection-oriented networks, internet concepts, application program interfaces, basic principles of layering, proto

Handbook on electronic commerce

Energy Technology Data Exchange (ETDEWEB)

Shaw, M. [Illinois Univ., Urbana, IL (United States). Beckman Inst. for Advanced Science and Technology; Blanning, R. [Vanderbilt Univ., Nashville, TN (United States). Owen Graduate School of Management; Strader, T. [Iowa State Univ., Ames, IA (United States). Management Information Systems; Whinston, A. [eds.] [Texas Univ., Austin, TX (United States). Dept. of Management Science and Information Systems

2000-07-01

The world is undergoing a revolution to a digital economy, with pronounced implications for corporate strategy, marketing, operations, information systems, customer services, global supply-chain management, and product distribution. This handbook examines the aspects of electronic commerce, including electronic storefront, on-line business, consumer interface, business-to-business networking, digital payment, legal issues, information product development, and electronic business models. Indispensable for academics, students and professionals who are interested in Electronic Commerce and Internet Business. (orig.)

Handbook of fiber optic data communication a practical guide to optical networking

CERN Document Server

DeCusatis, Casimer

2008-01-01

The third edition of this Handbook provides a comprehensive, easy to use guide to the field of optical fiber data communications. Written by experts in the industry from major companies such as IBM, Cisco and Nortel, the Handbook is a key reference for optical fiber technology, networking, protocols, applications, manufacturing, and future directions. It includes chapters on all the major industry standards, written by the same experts who developed them.This edition contains new material on transceiver form factors (QSFP, SFP +, XFP, X2), manufacturing standards, including JEDEC and R

Summary of project to develop handbook of human reliability analysis for nuclear power plant operations

International Nuclear Information System (INIS)

Swain, A.D.

1978-01-01

For the past two years Alan Swain and Henry E. Guttmann, of the Statistics, Computing, and Human Factors Division, Sandia Laboratories, have been developing a handbook to aid qualified persons to evaluate the effect of human error on the availability of engineered safety systems and features in nuclear power plants. The handbook includes a mathematical model, procedures, derived human failure data, and principles of human behavior and ergonomics. The handbook is expanding the human error analyses which were presented in WASH--1400. The work, under the sponsorship of Probabilistic Analysis Staff, NRC Office of Nuclear Regulatory Research (Dr. M.C. Cullingford, NRC Program Manager), is about half completed. An outline of the handbook contents is given in copies of vugraphs (attached), followed by copies of human performance model abstractors (also attached). A first draft of the handbook is scheduled for NRC review by July 1, 1979

Newnes electronics assembly handbook

CERN Document Server

Brindley, Keith

2013-01-01

Newnes Electronics Assembly Handbook: Techniques, Standards and Quality Assurance focuses on the aspects of electronic assembling. The handbook first looks at the printed circuit board (PCB). Base materials, basic mechanical properties, cleaning of assemblies, design, and PCB manufacturing processes are then explained. The text also discusses surface mounted assemblies and packaging of electromechanical assemblies, as well as the soldering process. Requirements for the soldering process; solderability and protective coatings; cleaning of PCBs; and mass solder/component reflow soldering are des

The biodiesel handbook

National Research Council Canada - National Science Library

Knothe, Gerhard; Krahl, Jurgen; Van Gerpen, Jon Harlan

2010-01-01

.... The Biodiesel Handbook delivers solutions to issues associated with biodiesel feedstocks, production issues, quality control, viscosity, stability, applications, emissions, and other environmental...

Selected Thermophysical Properties of 2,2 Dimethylcyclopentyl Methylphosphonofluoridate (GP) and 2,2 Dimethylcyclopentanol (DMCP)

Science.gov (United States)

2016-09-01

chromatography using a thermal conductivity detector (GC-TCD). Table 1. Sample Information for GP and DMCP Chemical Name Mole Fraction Purity...Proving Ground, MD, 1983; UNCLASSIFIED Report (ADC033491). 23. Weast, R.C. CRC Handbook of Chemistry and Physics, 53rd ed.; CRC Press: Boca Raton, FL...gas chromatography GD pinacolyl methylphosphonofluoridate GF cyclohexyl methylphosphonofluoridate GP 2,2-dimethylcyclopentyl

Springer handbook of robotics

CERN Document Server

Khatib, Oussama

2016-01-01

The second edition of this handbook provides a state-of-the-art cover view on the various aspects in the rapidly developing field of robotics. Reaching for the human frontier, robotics is vigorously engaged in the growing challenges of new emerging domains. Interacting, exploring, and working with humans, the new generation of robots will increasingly touch people and their lives. The credible prospect of practical robots among humans is the result of the scientific endeavour of a half a century of robotic developments that established robotics as a modern scientific discipline. The ongoing vibrant expansion and strong growth of the field during the last decade has fueled this second edition of the Springer Handbook of Robotics. The first edition of the handbook soon became a landmark in robotics publishing and won the American Association of Publishers PROSE Award for Excellence in Physical Sciences & Mathematics as well as the organization’s Award for Engineering & Technology. The second edition o...

Criticality handbook. Pt. 1

International Nuclear Information System (INIS)

Heinicke, W.; Krug, H.; Thomas, W.; Weber, W.; Gmal, B.

1985-12-01

The GRS Criticality Handbook is intended as a source of information on criticality problems for the persons concerned in industry, authorities, or research laboratories. It is to serve as a guide allowing quick and appropriate evaluation of criticality problems during design or erection of nuclear installations. This present issue replaces the one published in 1979, presenting revised and new data in a modified construction, but within the framework of the proven basic structure of the Handbook. Some fundamental knowledge is required of criticality problems and the relevant terms and definitions of nuclear safety, in order to fully deploy the information given. Part 1 of the Handbook therefore first introduces terminology and definitions, followed by experimental methods and calculation models for criticality calculations. The next chapters deal with the function and efficiency of neutron reflectors and neutron absorbers, measuring methods for criticality monitoring, organisational safety measures, and criticality accidents and their subsequent analysis. (orig./HP) [de

A European handbook for teachers on radiation and radiation protection

International Nuclear Information System (INIS)

Teunen, D.

1994-01-01

The Commission of the European Communities (Directorate General XI) has taken several initiatives to assist Member States, one of them being the development of a handbook for teachers on radiation and radiation protection, in order to give teachers a clear, scientifically valid and objective set of materials to enable those who so wish to includes courses on radiation protection in their teaching programmes. The draft handbook has been tested in five countries and is to be published in English and French in 1993. Translations in all Community languages are envisaged

Speech-Language-Pathology and Audiology Handbook.

Science.gov (United States)

New York State Education Dept., Albany. Office of the Professions.

The handbook contains State Education Department rules and regulations that govern speech-language pathology and audiology in New York State. The handbook also describes licensure and first registration as a licensed speech-language pathologist or audiologist. The introduction discusses professional regulation in New York State while the second…

SCM Handbooks for dc-to-dc Converters

Science.gov (United States)

Lee, F.; Mohmoud, M.; Yu, Y.

1984-01-01

Two documents aid in design of control modules for dc-to-dc converters. Features of SCM include: Adaptive stability, power component stress limiting, implementation of various control laws, unified design approach. Analysis and quidelines contained in handbooks enable engineer to design SCM circuit and confidently predict resulting overall performance.

Aberrant gene methylation in non-neoplastic mucosa as a predictive marker of ulcerative colitis-associated CRC.

Science.gov (United States)

Scarpa, Marco; Scarpa, Melania; Castagliuolo, Ignazio; Erroi, Francesca; Kotsafti, Andromachi; Basato, Silvia; Brun, Paola; D'Incà, Renata; Rugge, Massimo; Angriman, Imerio; Castoro, Carlo

2016-03-01

BACKGROUND PROMOTER: hypermethylation plays a major role in cancer through transcriptional silencing of critical genes. The aim of our study is to evaluate the methylation status of these genes in the colonic mucosa without dysplasia or adenocarcinoma at the different steps of sporadic and UC-related carcinogenesis and to investigate the possible role of genomic methylation as a marker of CRC. The expression of Dnmts 1 and 3A was significantly increased in UC-related carcinogenesis compared to non inflammatory colorectal carcinogenesis. In non-neoplastic colonic mucosa, the number of methylated genes resulted significantly higher in patients with CRC and in those with UC-related CRC compared to the HC and UC patients and patients with dysplastic lesion of the colon. The number of methylated genes in non-neoplastic colonic mucosa predicted the presence of CRC with good accuracy either in non inflammatory and inflammatory related CRC. Colonic mucosal samples were collected from healthy subjects (HC) (n = 30) and from patients with ulcerative colitis (UC) (n = 29), UC and dysplasia (n = 14), UC and cancer (n = 10), dysplastic adenoma (n = 14), and colon adenocarcinoma (n = 10). DNA methyltransferases-1, -3a, -3b, mRNA expression were quantified by real time qRT-PCR. The methylation status of CDH13, APC, MLH1, MGMT1 and RUNX3 gene promoters was assessed by methylation-specific PCR. Methylation status of APC, CDH13, MGMT, MLH1 and RUNX3 in the non-neoplastic mucosa may be used as a marker of CRC: these preliminary results could allow for the adjustment of a patient's surveillance interval and to select UC patients who should undergo intensive surveillance.

Federal environmental inspections handbook

International Nuclear Information System (INIS)

1991-10-01

This Federal Environmental Inspection Handbook has been prepared by the Department of Energy (DOE), Office of Environmental Guidance, RCRA/CERCLA Division (EH-231). It is designed to provide DOE personnel with an easily accessible compilation of the environmental inspection requirements under Federal environmental statutes which may impact DOE operations and activities. DOE personnel are reminded that this Handbook is intended to be used in concert with, and not as a substitute for, the Code of Federal Regulations (CFR). Federal Register (FR), and other applicable regulatory documents

The Development of a Handbook for the Undecided Major at the State University of New York College at Purchase.

Science.gov (United States)

Wilkie, Dana A.

This practicum report describes design and development of a handbook to help undecided students at the State University of New York College at Purchase explore possible choices of major fields of study. In order to determine what elements should be included in the handbook, a search of the literature on handbook content and development process and…

Resource handbook on transport risk assessment (invited paper)

International Nuclear Information System (INIS)

Chen, S.Y.; Biwer, B.M.; Monette, F.A.; Luna, R.; Weiner, R.; Yoshimura, R.; Detrick, C.; Dunn, T.; Maheras, S.; Bhatnager, S.; Kapoor, A.K.

2003-01-01

The US Department of Energy's (DOE's) National Transportation Program established the DOE Transportation Risk Assessment Working Group (TRAWG) to develop the Resource Handbook on DOE Transportation Risk Assessment, published in July 2002. The working group is comprised of technical experts representing DOE national laboratories, the DOE Naval Reactors Program, and DOE contractors. The motivation behind preparing this handbook was to document and disseminate lessons learned and information accumulated from more than 20 years of experience by DOE and its contractors in preparing transport risk assessments that address the shipment of virtually all types of radioactive materials and wastes. The handbook is intended to serve as a primary source of information on conducting transport risk assessments for shipments of radioactive materials or wastes under both normal and accident conditions. The paper provides an overview of the information contained in the handbook. It should be recognised that development of radioactive materials transport risk assessment is an ongoing process, and that the analysis methods are regularly improved. The Resource Handbook on DOE Transportation Risk Assessment appears on the Web at www.ntp.doe.gov/transrisk_handbook.pdf. (author)

Saving time with a computerised handbook

International Nuclear Information System (INIS)

Henrie, D.K.

1993-01-01

The DE/CAASE computerised engineering handbook (Desktop Engineering, Mahwah, NJ, USA) is a software tool designed to automate a wide variety of engineering tasks that are typically performed with an engineering handbook and hand calculator. It significantly reduces the time taken to perform these tasks. For example, instead of spending 60 minutes on determining section properties of composite sections in control room panels and other equipment by hand, it might take less than 5 minutes by using the computerised handbook. Similarly, mode shapes and frequencies of simple structures may take less than 10 minutes to calculate, compared with the hours it used to take. (author)

High efficiency motor selection handbook

Science.gov (United States)

McCoy, Gilbert A.; Litman, Todd; Douglass, John G.

1990-10-01

Substantial reductions in energy and operational costs can be achieved through the use of energy-efficient electric motors. A handbook was compiled to help industry identify opportunities for cost-effective application of these motors. It covers the economic and operational factors to be considered when motor purchase decisions are being made. Its audience includes plant managers, plant engineers, and others interested in energy management or preventative maintenance programs.

LAWRENCE RADIATION LABORATORY COUNTING HANDBOOK

Energy Technology Data Exchange (ETDEWEB)

Group, Nuclear Instrumentation

1966-10-01

The Counting Handbook is a compilation of operational techniques and performance specifications on counting equipment in use at the Lawrence Radiation Laboratory, Berkeley. Counting notes have been written from the viewpoint of the user rather than that of the designer or maintenance man. The only maintenance instructions that have been included are those that can easily be performed by the experimenter to assure that the equipment is operating properly.

Handbook of compliant mechanisms

CERN Document Server

Howell, Larry L; Olsen, Brian M

2013-01-01

A fully illustrated reference book giving an easy-to-understand introduction to compliant mechanisms A broad compilation of compliant mechanisms to give inspiration and guidance to those interested in using compliant mechanisms in their designs, the Handbook of Compliant Mechanisms includes graphics and descriptions of many compliant mechanisms. It comprises an extensive categorization of devices that can be used to help readers identify compliant mechanisms related to their application. It also provides chapters on the basic background in compliant mechanisms, the categories o

Action Handbook for Automotive Service Instruction.

Science.gov (United States)

Motor Vehicle Manufacturers Association of the U.S., Inc., Detroit, MI.

The document is a handbook for a vocational automotive service education program which was formulated as a result of a four-day series of intensive workshops called the National Automotive Service Vocational Education Conference. The handbook discusses the major components of an automotive service vocational education program and aspects of their…

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria

Directory of Open Access Journals (Sweden)

O'Gara Fergal

2010-11-01

Full Text Available Abstract Background Catabolite repression control (CRC is an important global control system in Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of CRC in Pseudomonas spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5' end of an mRNA resulting in translational down-regulation of target genes. Despite the identification of several Crc targets in Pseudomonas spp. the Crc regulon has remained largely unexplored. Results In order to predict direct targets of Crc, we used a bioinformatics approach based on detection of A-rich motifs near the initiation of translation of all protein-encoding genes in twelve fully sequenced Pseudomonas genomes. As expected, our data predict that genes related to the utilisation of less preferred nutrients, such as some carbohydrates, nitrogen sources and aromatic carbon compounds are targets of Crc. A general trend in this analysis is that the regulation of transporters is conserved across species whereas regulation of specific enzymatic steps or transcriptional activators are often conserved only within a species. Interestingly, some nucleoid associated proteins (NAPs such as HU and IHF are predicted to be regulated by Crc. This finding indicates a possible role of Crc in indirect control over a subset of genes that depend on the DNA bending properties of NAPs for expression or repression. Finally, some virulence traits such as alginate and rhamnolipid production also appear to be regulated by Crc, which links nutritional status cues with the regulation of virulence traits. Conclusions Catabolite repression control regulates a broad spectrum of genes in Pseudomonas. Some targets are genus-wide and are typically related to central metabolism, whereas other targets are species-specific, or even unique to particular strains. Further study of these novel targets will enhance our understanding of how Pseudomonas

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria.

Science.gov (United States)

Browne, Patrick; Barret, Matthieu; O'Gara, Fergal; Morrissey, John P

2010-11-25

Catabolite repression control (CRC) is an important global control system in Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of CRC in Pseudomonas spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5' end of an mRNA resulting in translational down-regulation of target genes. Despite the identification of several Crc targets in Pseudomonas spp. the Crc regulon has remained largely unexplored. In order to predict direct targets of Crc, we used a bioinformatics approach based on detection of A-rich motifs near the initiation of translation of all protein-encoding genes in twelve fully sequenced Pseudomonas genomes. As expected, our data predict that genes related to the utilisation of less preferred nutrients, such as some carbohydrates, nitrogen sources and aromatic carbon compounds are targets of Crc. A general trend in this analysis is that the regulation of transporters is conserved across species whereas regulation of specific enzymatic steps or transcriptional activators are often conserved only within a species. Interestingly, some nucleoid associated proteins (NAPs) such as HU and IHF are predicted to be regulated by Crc. This finding indicates a possible role of Crc in indirect control over a subset of genes that depend on the DNA bending properties of NAPs for expression or repression. Finally, some virulence traits such as alginate and rhamnolipid production also appear to be regulated by Crc, which links nutritional status cues with the regulation of virulence traits. Catabolite repression control regulates a broad spectrum of genes in Pseudomonas. Some targets are genus-wide and are typically related to central metabolism, whereas other targets are species-specific, or even unique to particular strains. Further study of these novel targets will enhance our understanding of how Pseudomonas bacteria integrate nutritional status cues with the regulation

Computational prediction of the Crc regulon identifies genus-wide and species-specific targets of catabolite repression control in Pseudomonas bacteria

LENUS (Irish Health Repository)

Browne, Patrick

2010-11-25

Abstract Background Catabolite repression control (CRC) is an important global control system in Pseudomonas that fine tunes metabolism in order optimise growth and metabolism in a range of different environments. The mechanism of CRC in Pseudomonas spp. centres on the binding of a protein, Crc, to an A-rich motif on the 5\\' end of an mRNA resulting in translational down-regulation of target genes. Despite the identification of several Crc targets in Pseudomonas spp. the Crc regulon has remained largely unexplored. Results In order to predict direct targets of Crc, we used a bioinformatics approach based on detection of A-rich motifs near the initiation of translation of all protein-encoding genes in twelve fully sequenced Pseudomonas genomes. As expected, our data predict that genes related to the utilisation of less preferred nutrients, such as some carbohydrates, nitrogen sources and aromatic carbon compounds are targets of Crc. A general trend in this analysis is that the regulation of transporters is conserved across species whereas regulation of specific enzymatic steps or transcriptional activators are often conserved only within a species. Interestingly, some nucleoid associated proteins (NAPs) such as HU and IHF are predicted to be regulated by Crc. This finding indicates a possible role of Crc in indirect control over a subset of genes that depend on the DNA bending properties of NAPs for expression or repression. Finally, some virulence traits such as alginate and rhamnolipid production also appear to be regulated by Crc, which links nutritional status cues with the regulation of virulence traits. Conclusions Catabolite repression control regulates a broad spectrum of genes in Pseudomonas. Some targets are genus-wide and are typically related to central metabolism, whereas other targets are species-specific, or even unique to particular strains. Further study of these novel targets will enhance our understanding of how Pseudomonas bacteria integrate

Decision aiding handbooks for managing contaminated food production systems, drinking water and inhabited areas in Europe

DEFF Research Database (Denmark)

Nisbet, A.F.; Brown, J.; Howard, B.J.

2010-01-01

Three handbooks have been developed, in conjunction with a wide range of stakeholders to assist in the management of contaminated food production systems, inhabited areas and drinking water following a radiological incident. The handbooks are aimed at national and local authorities, central...... government departments and agencies, emergency services, radiation protection experts, the agriculture and food production sectors, industry and others who may be affected. The handbooks include management options for application in the different phases of an incident. Sources of contamination considered...

Aberrant methylation of GCNT2 is tightly related to lymph node metastasis of primary CRC.

Science.gov (United States)

Nakamura, Kazunori; Yamashita, Keishi; Sawaki, Hiromichi; Waraya, Mina; Katoh, Hiroshi; Nakayama, Nobukazu; Kawamata, Hiroshi; Nishimiya, Hiroshi; Ema, Akira; Narimatsu, Hisashi; Watanabe, Masahiko

2015-03-01

Glycoprotein expression profile is dramatically altered in human cancers; however, specific glycogenes have not been fully identified. A comprehensive real-time polymerase chain reaction (PCR) system for glycogenes (CRPS-G) identified several outstanding glycogenes. GCNT2 was of particular interest after GCNT2 expression and epigenetics were rigorously investigated in primary colorectal cancer (CRC). The highlights of this work can be summarized as follows: (i) Expression of GCNT2 was remarkably suppressed. (ii) Silenced expression of GCNT2 was reactivated by combined demethylating agents. (iii) Promoter DNA methylation of GCNT2 was silenced in CRC cell lines and tissues. Hypomethylation of GCNT2 variant 2 is tightly associated with lymph node metastasis in primary CRC. (iv) GCNT2 methylation level in the normal tissues also showed a close association with that in the tumor tissues and reflected lymph node metastasis. We identified aberrant expression of GCNT2, which can be explained by promoter DNA hypermethylation. Hypomethylation of the GCNT2 variant 2 reflected lymph node metastasis of CRC in the tumor and normal tissues. Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

The Crc and Hfq proteins of Pseudomonas putida cooperate in catabolite repression and formation of ribonucleic acid complexes with specific target motifs.

Science.gov (United States)

Moreno, Renata; Hernández-Arranz, Sofía; La Rosa, Ruggero; Yuste, Luis; Madhushani, Anjana; Shingler, Victoria; Rojo, Fernando

2015-01-01

The Crc protein is a global regulator that has a key role in catabolite repression and optimization of metabolism in Pseudomonads. Crc inhibits gene expression post-transcriptionally, preventing translation of mRNAs bearing an AAnAAnAA motif [the catabolite activity (CA) motif] close to the translation start site. Although Crc was initially believed to bind RNA by itself, this idea was recently challenged by results suggesting that a protein co-purifying with Crc, presumably the Hfq protein, could account for the detected RNA-binding activity. Hfq is an abundant protein that has a central role in post-transcriptional gene regulation. Herein, we show that the Pseudomonas putida Hfq protein can recognize the CA motifs of RNAs through its distal face and that Crc facilitates formation of a more stable complex at these targets. Crc was unable to bind RNA in the absence of Hfq. However, pull-down assays showed that Crc and Hfq can form a co-complex with RNA containing a CA motif in vitro. Inactivation of the hfq or the crc gene impaired catabolite repression to a similar extent. We propose that Crc and Hfq cooperate in catabolite repression, probably through forming a stable co-complex with RNAs containing CA motifs to result in inhibition of translation initiation. © 2014 Society for Applied Microbiology and John Wiley & Sons Ltd.

Training Program Handbook: A systematic approach to training

Energy Technology Data Exchange (ETDEWEB)

1994-08-01

This DOE handbook describes a systematic method for establishing and maintaining training programs that meet the requirements and expectations of DOE Orders 5480.18B and 5480.20. The systematic approach to training includes 5 phases: Analysis, design, development, implementation, and evaluation.

75 FR 5317 - Exposure Factors Handbook: 2009 Update

Science.gov (United States)

2010-02-02

... chemicals. These factors include: Drinking water consumption; mouthing behavior; soil ingestion rates... document solely for the purpose of pre- dissemination peer review under applicable information quality... various factors used in assessing human exposure. This Handbook is aimed at exposure assessors inside the...

Collecting, curating, and researching writers' libraries a handbook

CERN Document Server

Oram, Richard W

2014-01-01

Collecting, Curating, and Researching Writers' Libraries: A Handbook is the first book to examine the history, acquisition, cataloging, and scholarly use of writers' personal libraries. This book also includes interviews with several well-known writers, who discuss their relationship with their books.

Information security management handbook

CERN Document Server

2002-01-01

The Information Security Management Handbook continues its tradition of consistently communicating the fundamental concepts of security needed to be a true CISSP. In response to new developments, Volume 4 supplements the previous volumes with new information covering topics such as wireless, HIPAA, the latest hacker attacks and defenses, intrusion detection, and provides expanded coverage on security management issues and applications security. Even those that don't plan on sitting for the CISSP exam will find that this handbook is a great information security reference.The changes in the tech

The french criticality handbook

International Nuclear Information System (INIS)

Maubert, L.; Puit, J.C.

1987-01-01

The french criticality handbook, published in 1978 by the ''Commissariat a l'Energie Atomique'', is presented with the main targets aimed by the writer and the main choices taken relating to fissile mediums, reflection conditions, dilution curves. The validation of the critical values is presented as one of the most important aspects of this handbook which is mainly intended, in the mind of the author, to specialists well advertised in the field of criticality. The complements which have been introduced since 1978 and those which are foreseen in a near future are also detailed. (author)

Information security management handbook

CERN Document Server

Tipton, Harold F

2003-01-01

Since 1993, the Information Security Management Handbook has served not only as an everyday reference for information security practitioners but also as an important document for conducting the intense review necessary to prepare for the Certified Information System Security Professional (CISSP) examination. Now completely revised and updated and in its fifth edition, the handbook maps the ten domains of the Information Security Common Body of Knowledge and provides a complete understanding of all the items in it. This is a ...must have... book, both for preparing for the CISSP exam and as a c

Handbook of surveillance technologies

CERN Document Server

Petersen, JK

2012-01-01

From officially sanctioned, high-tech operations to budget spy cameras and cell phone video, this updated and expanded edition of a bestselling handbook reflects the rapid and significant growth of the surveillance industry. The Handbook of Surveillance Technologies, Third Edition is the only comprehensive work to chronicle the background and current applications of the full-range of surveillance technologies--offering the latest in surveillance and privacy issues.Cutting-Edge--updates its bestselling predecessor with discussions on social media, GPS circuits in cell phones and PDAs, new GIS s

Software quality assurance handbook

Energy Technology Data Exchange (ETDEWEB)

1990-09-01

There are two important reasons for Software Quality Assurance (SQA) at Allied-Signal Inc., Kansas City Division (KCD): First, the benefits from SQA make good business sense. Second, the Department of Energy has requested SQA. This handbook is one of the first steps in a plant-wide implementation of Software Quality Assurance at KCD. The handbook has two main purposes. The first is to provide information that you will need to perform software quality assurance activities. The second is to provide a common thread to unify the approach to SQA at KCD. 2 figs.

Buying green! A handbook on green energy procurement. 2nd edition

Energy Technology Data Exchange (ETDEWEB)

NONE

2011-11-10

Over 2 trillion Euros is spent on public contracts on a yearly basis in the EU, translating to 19 percent of its GDP. ICLEI has been working with the European Commission to produce guidance on green public procurement (GPP) which will help public authorities to reduce their environmental impact, while complying with the procurement rules. The result is the new edition of the Buying Green! handbook. The handbook identifies strategies for GPP, and explains in detail how these can be implemented at each stage of the procurement process. It is intended for public sector procurers but is also a useful reference for policy makers and businesses who are either implementing their own green purchasing or responding to tenders. In addition to explaining how GPP can be implemented under the EU procurement rules, the handbook includes examples of green contracts from across the EU-27. The resource has been fully updated from the previous 2004 edition and includes expanded sections on life-cycle costing (LCC) and the construction, timber, electricity and food and drink sectors.

The Yaws handbook of vapor pressure Antoine coefficients

CERN Document Server

Yaws, Carl L

2015-01-01

Increased to include over 25,000 organic and inorganic compounds, The Yaws Handbook of Vapor Pressure: Antoine Coefficients, 2nd Edition delivers the most comprehensive and practical database source for today's petrochemical. Understanding antoine coefficients for vapor pressure leads to numerous critical engineering applications such as pure components in storage vessels, pressure relief valve design, flammability limits at the refinery, as well as environmental emissions from exposed liquids, making data to efficiently calculate these daily challenges a fundamental need. Written by the world's leading authority on chemical and petrochemical data, The Yaws Handbook of Vapor Pressure simplifies the guesswork for the engineer and reinforces the credibility of the engineer's calculations with a single trust-worthy source. This data book is a must-have for the engineer's library bookshelf. Increase compound coverage from 8,200 to over 25,000 organic and inorganic compounds, including sulfur and hydrocarbons Sol...

Quantitative proteomics unravels that the post-transcriptional regulator Crc modulates the generation of vesicles and secreted virulence determinants of Pseudomonas aeruginosa.

Science.gov (United States)

Reales-Calderón, Jose Antonio; Corona, Fernando; Monteoliva, Lucía; Gil, Concha; Martínez, Jose Luis

2015-09-08

Recent research indicates that the post-transcriptional regulator Crc modulates susceptibility to antibiotics and virulence in Pseudomonas aeruginosa. Several P. aeruginosa virulence factors are secreted or engulfed in vesicles. To decipher the Crc modulation of P. aeruginosa virulence, we constructed a crc deficient mutant and measure the proteome associated extracellular vesicles and the vesicle-free secretome using iTRAQ. Fifty vesicle-associated proteins were more abundant and 14 less abundant in the crc-defective strain, whereas 37 were more abundant and 17 less abundant in the vesicle-free secretome. Among them, virulence determinants, such as ToxA, protease IV, azurin, chitin-binding protein, PlcB and Hcp1, were less abundant in the crc-defective mutant. Transcriptomic analysis revealed that some of the observed changes were post-transcriptional and, thus, could be attributed to a direct Crc regulatory role; whereas, for other differentially secreted proteins, the regulatory role was likely indirect. We also observed that the crc mutant presented an impaired vesicle-associated secretion of quorum sensing signal molecules and less cytotoxicity than its wild-type strain. Our results offer new insights into the mechanisms by which Crc regulates P. aeruginosa virulence, through the modulation of vesicle formation and secretion of both virulence determinants and quorum sensing signals. This article is part of a Special Issue entitled: HUPO 2014. Published by Elsevier B.V.

Fault tree handbook

International Nuclear Information System (INIS)

Haasl, D.F.; Roberts, N.H.; Vesely, W.E.; Goldberg, F.F.

1981-01-01

This handbook describes a methodology for reliability analysis of complex systems such as those which comprise the engineered safety features of nuclear power generating stations. After an initial overview of the available system analysis approaches, the handbook focuses on a description of the deductive method known as fault tree analysis. The following aspects of fault tree analysis are covered: basic concepts for fault tree analysis; basic elements of a fault tree; fault tree construction; probability, statistics, and Boolean algebra for the fault tree analyst; qualitative and quantitative fault tree evaluation techniques; and computer codes for fault tree evaluation. Also discussed are several example problems illustrating the basic concepts of fault tree construction and evaluation

Instrumentation Hardware Abstraction Language (IHAL) Handbook

Science.gov (United States)

2017-01-01

WING 96TH TEST WING 412TH TEST WING ARNOLD ENGINEERING DEVELOPMENT COMPLEX NATIONAL AERONAUTICS AND SPACE ADMINISTRATION This page...configuration tool was pre-loaded with an IHAL configuration consisting of one DAU connected to three different analog signal conditioning cards, for a total of...not be illustrated in this handbook. 4 Recall that XML elements and types can include a namespace

Data Collection Handbook to Support Modeling Impacts of Radioactive Material in Soil and Building Structures

Energy Technology Data Exchange (ETDEWEB)

Yu, Charley [Argonne National Lab. (ANL), Argonne, IL (United States); Kamboj, Sunita [Argonne National Lab. (ANL), Argonne, IL (United States); Wang, Cheng [Argonne National Lab. (ANL), Argonne, IL (United States); Cheng, Jing-Jy [Argonne National Lab. (ANL), Argonne, IL (United States)

2015-09-01

This handbook is an update of the 1993 version of the Data Collection Handbook and the Radionuclide Transfer Factors Report to support modeling the impact of radioactive material in soil. Many new parameters have been added to the RESRAD Family of Codes, and new measurement methodologies are available. A detailed review of available parameter databases was conducted in preparation of this new handbook. This handbook is a companion document to the user manuals when using the RESRAD (onsite) and RESRAD-OFFSITE code. It can also be used for RESRAD-BUILD code because some of the building-related parameters are included in this handbook. The RESRAD (onsite) has been developed for implementing U.S. Department of Energy Residual Radioactive Material Guidelines. Hydrogeological, meteorological, geochemical, geometrical (size, area, depth), crops and livestock, human intake, source characteristic, and building characteristic parameters are used in the RESRAD (onsite) code. The RESRAD-OFFSITE code is an extension of the RESRAD (onsite) code and can also model the transport of radionuclides to locations outside the footprint of the primary contamination. This handbook discusses parameter definitions, typical ranges, variations, and measurement methodologies. It also provides references for sources of additional information. Although this handbook was developed primarily to support the application of RESRAD Family of Codes, the discussions and values are valid for use of other pathway analysis models and codes.

Faculty Handbook -- 1974-1976. Montana State University, Bozeman.

Science.gov (United States)

Montana State Univ., Bozeman.

The Montana State University's 1974 faculty handbook outlines the history and scope of the university within the Montana state higher education system. The document details the administrative organization; the faculty organization and operation; personnel policies including appointments, tenure, rank and titles, faculty review, promotions,…

Handbook of reference electrodes

CERN Document Server

Inzelt, György; Scholz, Fritz

2013-01-01

Reference Electrodes are a crucial part of any electrochemical system, yet an up-to-date and comprehensive handbook is long overdue. Here, an experienced team of electrochemists provides an in-depth source of information and data for the proper choice and construction of reference electrodes. This includes all kinds of applications such as aqueous and non-aqueous solutions, ionic liquids, glass melts, solid electrolyte systems, and membrane electrodes. Advanced technologies such as miniaturized, conducting-polymer-based, screen-printed or disposable reference electrodes are also covered. Essen

Handbook of visual communications

CERN Document Server

Hang, Hseuh-Ming

1995-01-01

Handbook of Visual Communications explores the latest developments in the field, such as model-based image coding, and provides readers with insight into possible future developments.Key Features* Displays comprehensive coverage from fundamental theory to international standards and VLSI design* Includes 518 pages of contributions from well-known experts* [please keep this feature current with the page count]* Presents state-of-the-art knowledge--the most up-to-date and accurate information on various topics in the field* Provides an extensive overview of international standards for industrial

Heat pump planning handbook

CERN Document Server

Bonin, Jürgen

2015-01-01

The Heat Pump Planning Handbook contains practical information and guidance on the design, planning and selection of heat pump systems, allowing engineers, designers, architects and construction specialists to compare a number of different systems and options. Including detailed descriptions of components and their functions and reflecting the current state of technology this guide contains sample tasks and solutions as well as new model calculations and planning evaluations. Also economic factors and alternative energy sources are covered, which are essential at a time of rising heat costs. T

Alternatives to Arsine: The Atmospheric Pressure Organometallic Chemical Vapor Deposition Growth of GaAs Using Triethylarsenic.

Science.gov (United States)

1987-08-15

also found to affect residual doping type at a low V/Ill ratio and had a significant effect upon epilayer 6 650 - A~ N-TYPE (3 sipm) A N-TYPE (2 stpm ...editor, "CRC Handbook of Chemistry and Physics ," 64th ed., F-177,179 (CRC Press, Inc., Boca Raton, Florida, 1983). 7. P.D. Dapkus, H.M. Manasevit, K.L

Handbook of methods for risk-based analyses of technical specifications

International Nuclear Information System (INIS)

Samanta, P.K.; Kim, I.S.; Mankamo, T.; Vesely, W.E.

1994-12-01

Technical Specifications (TS) requirements for nuclear power plants define the Limiting Conditions for Operation (LCOs) and Surveillance Requirements (SRs) to assure safety during operation. In general, these requirements are based on deterministic analysis and engineering judgments. Experiences with plant operation indicate that some elements of the requirements are unnecessarily restrictive, while a few may not be conducive to safety. The US Nuclear Regulatory Commission (USNRC) Office of Research has sponsored research to develop systematic risk-based methods to improve various aspects of TS requirements. This handbook summarizes these risk-based methods. The scope of the handbook includes reliability and risk-based methods for evaluating allowed outage times (AOTs), scheduled or preventive maintenance, action statements requiring shutdown where shutdown risk may be substantial, surveillance test intervals (STIs), and management of plant configurations resulting from outages of systems, or components. For each topic, the handbook summarizes analytic methods with data needs, outlines the insights to be gained, lists additional references, and gives examples of evaluations

Handbook of methods for risk-based analyses of technical specifications

Energy Technology Data Exchange (ETDEWEB)

Samanta, P.K.; Kim, I.S. [Brookhaven National Lab., Upton, NY (United States); Mankamo, T. [Avaplan Oy, Espoo (Finland); Vesely, W.E. [Science Applications International Corp., Dublin, OH (United States)

1994-12-01

Technical Specifications (TS) requirements for nuclear power plants define the Limiting Conditions for Operation (LCOs) and Surveillance Requirements (SRs) to assure safety during operation. In general, these requirements are based on deterministic analysis and engineering judgments. Experiences with plant operation indicate that some elements of the requirements are unnecessarily restrictive, while a few may not be conducive to safety. The US Nuclear Regulatory Commission (USNRC) Office of Research has sponsored research to develop systematic risk-based methods to improve various aspects of TS requirements. This handbook summarizes these risk-based methods. The scope of the handbook includes reliability and risk-based methods for evaluating allowed outage times (AOTs), scheduled or preventive maintenance, action statements requiring shutdown where shutdown risk may be substantial, surveillance test intervals (STIs), and management of plant configurations resulting from outages of systems, or components. For each topic, the handbook summarizes analytic methods with data needs, outlines the insights to be gained, lists additional references, and gives examples of evaluations.

Using a handbook to improve nurses' continence care.

Science.gov (United States)

Williams, K; Roe, B; Sindhu, F

Nursing care should be based on sound research evidence with demonstrated clinical effectiveness. Dissemination of this research evidence is, therefore, of paramount importance. A study using focus groups was undertaken during 1993-1994 to evaluate the dissemination of a clinical handbook for continence care to qualified nurses, in relation to reported nursing practice in care of the elderly wards/units in one health authority. A total of 124 nurses participated in the study and 98 variables were included. Improvements were recorded in nurses' responses between the pre-test and post-test for 84 (86 per cent) variables in the experimental group and 58 (59 per cent) in the control group. This demonstrates the positive value of the clinical handbook as a method of disseminating research evidence.

Handbook of digital games and entertainment technologies

NARCIS (Netherlands)

Nakatsu, R.; Rauterberg, G.W.M.; Ciancarini, P.

2017-01-01

The topics treated in this handbook cover all areas of games and entertainment technologies, such as digital entertainment; technology, design/art, and sociology. The handbook consists of contributions from top class scholars and researchers from the interdisciplinary topic areas. The aim of this

Crisis Communication (Handbooks of Communication Science Vol. 23)

DEFF Research Database (Denmark)

Johansen, Winni

Vol. 23 - The Handbook of Communication Science General editors: Peter J. Schultz and Paul Cobley......Vol. 23 - The Handbook of Communication Science General editors: Peter J. Schultz and Paul Cobley...

The global regulator Crc plays a multifaceted role in modulation of type III secretion system in Pseudomonas aeruginosa.

Science.gov (United States)

Dong, Yi-Hu; Zhang, Xi-Fen; Zhang, Lian-Hui

2013-02-01

The opportunistic pathogen Pseudomonas aeruginosa utilizes type III secretion system (T3SS) to translocate effector proteins into eukaryotic host cells that subvert normal host cell functions to the benefit of the pathogen, and results in serious infections. T3SS in P. aeruginosa is controlled by a complex system of regulatory mechanisms and signaling pathways. In this study, we described that Crc, an RNA-binding protein, exerts a positive impact on T3SS in P. aeruginosa, as evidenced by promoter activity assays of several key T3SS genes, transcriptomics, RT-PCR, and immunoblotting in crc mutant. We further demonstrated that the regulatory function of Crc on the T3SS was mediated through the T3SS master regulator ExsA and linked to the Cbr/Crc signaling system. Expression profiling of the crc mutant revealed a downregulation of flagship T3SS genes as well as 16 other genes known to regulate T3SS gene expression in P. aeruginosa. On the basis of these data, we proposed that Crc may exert multifaceted control on the T3SS through various pathways, which may serve to fine-tune this virulence mechanism in response to environmental changes and nutrient sources. © 2012 The Authors. Published by Blackwell Publishing Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

School handbooks from yesterday to today: Thefrench example

Directory of Open Access Journals (Sweden)

Alain CHOPPIN

2013-11-01

Full Text Available The school handbook has been for a long time devaluated for bibliographers, archivists and even for the historian community, but durign the last decades and increasing interest hast emerged among educational and textbook historians. First of all, the author the reasons of a textbook as an important source for the historian and the motives of such an unexpected interest for this subject, and afterwards make a brief historical review of the French school edition, specially focoused to the evolution of the handbook as a pedagogical tool. He tries to enlighten the different parameters that could have been successively implicated in the concept and use of handbooks in France, joining it closely current questions (increasingly complex handbooks, incidence of advanced technologies, teacher's training.

DOE Fundamentals Handbook: Thermodynamics, Heat Transfer, and Fluid Flow, Volume 1

International Nuclear Information System (INIS)

1992-06-01

The Thermodynamics, Heat Transfer, and Fluid Flow Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of the thermal sciences. The handbook includes information on thermodynamics and the properties of fluids; the three modes of heat transfer -- conduction, convection, and radiation; and fluid flow, and the energy relationships in fluid systems. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility fluid systems

DOE Fundamentals Handbook: Thermodynamics, Heat Transfer, and Fluid Flow, Volume 3

International Nuclear Information System (INIS)

1992-06-01

The Thermodynamics, Heat Transfer, and Fluid Flow Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of the thermal sciences. The handbook includes information on thermodynamics and the properties of fluids; the three modes of heat transfer -- conduction, convection, and radiation; and fluid flow, and the energy relationships in fluid systems. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility fluid systems

DOE Fundamentals Handbook: Thermodynamics, Heat Transfer, and Fluid Flow, Volume 2

International Nuclear Information System (INIS)

1992-06-01

The Thermodynamics, Heat Transfer, and Fluid Flow Fundamentals Handbook was developed to assist nuclear facility operating contractors provide operators, maintenance personnel, and the technical staff with the necessary fundamentals training to ensure a basic understanding of the thermal sciences. The handbook includes information on thermodynamics and the properties of fluids; the three modes of heat transfer -- conduction, convection, and radiation; and fluid flow, and the energy relationships in fluid systems. This information will provide personnel with a foundation for understanding the basic operation of various types of DOE nuclear facility fluid systems

Handbook of signal processing systems

CERN Document Server

Deprettere, Ed; Leupers, Rainer; Takala, Jarmo

2013-01-01

Handbook of Signal Processing Systems is organized in three parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications; the third part focuses on compilers and simulation tools, describes models of computation and their associated design tools and methodologies. This handbook is an essential tool for professionals in many fields and researchers of all levels.

Handbook of Global and Multicultural Negotiation

CERN Document Server

Moore, Christopher W

2010-01-01

Handbook of Global and Multicultural Negotiation provides advice and strategies for effective cross-cultural negotiations. Written from a multicultural perspective, this guidebook explores cross-cultural communication for problem solving and negotiations. This resource includes real-life stories and examples compiled from over thirty years of domestic and global experience from both authors, including Chris Moore, a well-known international negotiator and best selling author. This step-by-step guide to negotiation provides practical recommendations, advice, and globally proven strategies to pr

"Come to Chimera!" 1978: A Librarian's Planning Handbook.

Science.gov (United States)

Lukenbill, Shirley; Lesser, Anita

This handbook, prepared to assist librarians in planning summer reading programs for children, includes suggestions on the following: (1) establishing program goals, objectives, and activities; (2) supplies, resources, and materials needed for the program; (3) sample registration, evaluation, and volunteer recruitment forms; (4) types of publicity…

Handbook of interatomic potentials

International Nuclear Information System (INIS)

Stoneham, A.M.; Taylor, R.

1981-08-01

This Handbook collects together interatomic potentials for a large number of metals. Most of the potentials describe the interactions of host metal atoms with each other, and these, in some cases, may be applied to solid and liquid metals. In addition, there are potentials (a) for a metallic impurity alloyed with the host, (b) for a small number of chemical impurities in the metal (eg H, O), and (c) for rare-gas impurities, notably He. The Handbook is intended to be a convenient source of potentials for bulk, surface and defect calculations, both static and dynamic. (author)

Handbook of relativistic quantum chemistry

International Nuclear Information System (INIS)

Liu, Wenjian

2017-01-01

This handbook focuses on the foundations of relativistic quantum mechanics and addresses a number of fundamental issues never covered before in a book. For instance: How can many-body theory be combined with quantum electrodynamics? How can quantum electrodynamics be interfaced with relativistic quantum chemistry? What is the most appropriate relativistic many-electron Hamiltonian? How can we achieve relativistic explicit correlation? How can we formulate relativistic properties? - just to name a few. Since relativistic quantum chemistry is an integral component of computational chemistry, this handbook also supplements the ''Handbook of Computational Chemistry''. Generally speaking, it aims to establish the 'big picture' of relativistic molecular quantum mechanics as the union of quantum electrodynamics and relativistic quantum chemistry. Accordingly, it provides an accessible introduction for readers new to the field, presents advanced methodologies for experts, and discusses possible future perspectives, helping readers understand when/how to apply/develop the methodologies.

Improving diagnosis, prognosis and prediction by using biomarkers in CRC patients (Review).

Science.gov (United States)

Nikolouzakis, Taxiarchis Konstantinos; Vassilopoulou, Loukia; Fragkiadaki, Persefoni; Mariolis Sapsakos, Theodoros; Papadakis, Georgios Z; Spandidos, Demetrios A; Tsatsakis, Aristides M; Tsiaoussis, John

2018-06-01

Colorectal cancer (CRC) is among the most common cancers. In fact, it is placed in the third place among the most diagnosed cancer in men, after lung and prostate cancer, and in the second one for the most diagnosed cancer in women, following breast cancer. Moreover, its high mortality rates classifies it among the leading causes of cancer‑related death worldwide. Thus, in order to help clinicians to optimize their practice, it is crucial to introduce more effective tools that will improve not only early diagnosis, but also prediction of the most likely progression of the disease and response to chemotherapy. In that way, they will be able to decrease both morbidity and mortality of their patients. In accordance with that, colon cancer research has described numerous biomarkers for diagnostic, prognostic and predictive purposes that either alone or as part of a panel would help improve patient's clinical management. This review aims to describe the most accepted biomarkers among those proposed for use in CRC divided based on the clinical specimen that is examined (tissue, faeces or blood) along with their restrictions. Lastly, new insight in CRC monitoring will be discussed presenting promising emerging biomarkers (telomerase activity, telomere length and micronuclei frequency).

Expression of the MAP kinase phosphatase DUSP4 is associated with microsatellite instability in colorectal cancer (CRC) and causes increased cell proliferation.

Science.gov (United States)

Gröschl, Benedikt; Bettstetter, Marcus; Giedl, Christian; Woenckhaus, Matthias; Edmonston, Tina; Hofstädter, Ferdinand; Dietmaier, Wolfgang

2013-04-01

DUSP4 (MKP-2), a member of the mitogen-activated protein kinase phosphatase (MKP) family and potential tumor suppressor, negatively regulates the MAPKs (mitogen-activated protein kinases) ERK, p38 and JNK. MAPKs play a crucial role in cancer development and progression. Previously, using microarray analyses we found a conspicuously frequent overexpression of DUSP4 in colorectal cancer (CRC) with high frequent microsatellite instability (MSI-H) compared to microsatellite stable (MSS) CRC. Here we studied DUSP4 expression on mRNA level in 38 CRC (19 MSI-H and 19 MSS) compared to matched normal tissue as well as in CRC cell lines by RT-qPCR. DUSP4 was overexpressed in all 19 MSI-H tumors and in 14 MSS tumors. Median expression levels in MSI-H tumors were significantly higher than in MSS-tumors (p CRC cell lines showed 6.8-fold higher DUSP4 mRNA levels than MSS cell lines. DUSP4 expression was not regulated by promoter methylation since no methylation was found by quantitative methylation analysis of DUSP4 promoter in CRC cell lines neither in tumor samples. Furthermore, no DUSP4 mutation was found on genomic DNA level in four CRC cell lines. DUSP4 overexpression in CRC cell lines through DUSP4 transfection caused upregulated expression of MAPK targets CDC25A, CCND1, EGR1, FOS, MYC and CDKN1A in HCT116 as well as downregulation of mismatch repair gene MSH2 in SW480. Furthermore, DUSP4 overexpression led to increased proliferation in CRC cell lines. Our findings suggest that DUSP4 acts as an important regulator of cell growth within the MAPK pathway and causes enhanced cell growth in MSI-H CRC. Copyright © 2012 UICC.

Handbook of Signal Processing in Acoustics

CERN Document Server

Havelock, David; Vorländer, Michael

2009-01-01

The Handbook of Signal Processing in Acoustics presents signal processing as it is practiced in the field of acoustics. The Handbook is organized by areas of acoustics, with recognized leaders coordinating the self-contained chapters of each section. It brings together a wide range of perspectives from over 100 authors to reveal the interdisciplinary nature of signal processing in acoustics. Success in acoustic applications often requires juggling both the acoustic and the signal processing parameters of the problem. This handbook brings the key issues from both into perspective and is complementary to other reference material on the two subjects. It is a unique resource for experts and practitioners alike to find new ideas and techniques within the diversity of signal processing in acoustics.

Handbook of Research on Environmental Taxation

DEFF Research Database (Denmark)

, their environmental and economic impact and, finally, the larger question of the role of taxation among other policy approaches to environmental protection. Intermixing theory with case studies, the Handbook offers readers lessons that can be applied around the world. It identifies key bodies of research for people......The Handbook of Research on Environmental Taxation captures the state of the art of research on environmental taxation. Written by 36 specialists in environmental taxation from 16 countries, it takes an interdisciplinary and international approach, focusing on issues that are universal to using...... taxation to achieve environmental goals. The Handbook explores the conceptual foundations of environmental taxation, essential elements for designing environmental tax measures, factors that influence the acceptance of environmental taxation, the variety of ways to implement environmental taxes...

Fuel Cell Handbook, Fifth Edition

Energy Technology Data Exchange (ETDEWEB)

Energy and Environmental Solutions

2000-10-31

Progress continues in fuel cell technology since the previous edition of the Fuel Cell Handbook was published in November 1998. Uppermost, polymer electrolyte fuel cells, molten carbonate fuel cells, and solid oxide fuel cells have been demonstrated at commercial size in power plants. The previously demonstrated phosphoric acid fuel cells have entered the marketplace with more than 220 power plants delivered. Highlighting this commercial entry, the phosphoric acid power plant fleet has demonstrated 95+% availability and several units have passed 40,000 hours of operation. One unit has operated over 49,000 hours. Early expectations of very low emissions and relatively high efficiencies have been met in power plants with each type of fuel cell. Fuel flexibility has been demonstrated using natural gas, propane, landfill gas, anaerobic digester gas, military logistic fuels, and coal gas, greatly expanding market opportunities. Transportation markets worldwide have shown remarkable interest in fuel cells; nearly every major vehicle manufacturer in the U.S., Europe, and the Far East is supporting development. This Handbook provides a foundation in fuel cells for persons wanting a better understanding of the technology, its benefits, and the systems issues that influence its application. Trends in technology are discussed, including next-generation concepts that promise ultrahigh efficiency and low cost, while providing exceptionally clean power plant systems. Section 1 summarizes fuel cell progress since the last edition and includes existing power plant nameplate data. Section 2 addresses the thermodynamics of fuel cells to provide an understanding of fuel cell operation at two levels (basic and advanced). Sections 3 through 8 describe the six major fuel cell types and their performance based on cell operating conditions. Alkaline and intermediate solid state fuel cells were added to this edition of the Handbook. New information indicates that manufacturers have stayed

HVAC systems design handbook

CERN Document Server

Haines, Roger W

2010-01-01

Thoroughly updated with the latest codes, technologies, and practices, this all-in-one resource provides details, calculations, and specifications for designing efficient and effective residential, commercial, and industrial HVAC systems. HVAC Systems Design Handbook, Fifth Edition, features new information on energy conservation and computer usage for design and control, as well as the most recent International Code Council (ICC) Mechanical Code requirements. Detailed illustrations, tables, and essential HVAC equations are also included. This comprehensive guide contains everything you need to design, operate, and maintain peak-performing HVAC systems.

Near field communications handbook

CERN Document Server

Ahson, Syed A; Furht, Borko

2011-01-01

Near Field Communication, or NFC, is a short-range high frequency wireless communication technology that enables the exchange of data between devices over about a decimeter. The technology is a simple extension of the ISO 14443 proximity-card standard (contact less card, RFID) that combines the interface of a smart card and a reader into a single device with practical implications. A complete reference for NFC, this handbook provides technical information about all aspects of NFC, as well as applications. It covers basic concepts as well as research grade material and includes a discussion of

Handbook for sound engineers

CERN Document Server

Ballou, Glen

2015-01-01

Handbook for Sound Engineers is the most comprehensive reference available for audio engineers, and is a must read for all who work in audio.With contributions from many of the top professionals in the field, including Glen Ballou on interpretation systems, intercoms, assistive listening, and fundamentals and units of measurement, David Miles Huber on MIDI, Bill Whitlock on audio transformers and preamplifiers, Steve Dove on consoles, DAWs, and computers, Pat Brown on fundamentals, gain structures, and test and measurement, Ray Rayburn on virtual systems, digital interfacing, and preamplifiers

Handbook of linear algebra

CERN Document Server

Hogben, Leslie

2013-01-01

With a substantial amount of new material, the Handbook of Linear Algebra, Second Edition provides comprehensive coverage of linear algebra concepts, applications, and computational software packages in an easy-to-use format. It guides you from the very elementary aspects of the subject to the frontiers of current research. Along with revisions and updates throughout, the second edition of this bestseller includes 20 new chapters.New to the Second EditionSeparate chapters on Schur complements, additional types of canonical forms, tensors, matrix polynomials, matrix equations, special types of

Seals and sealing handbook

CERN Document Server

Flitney, Robert K

2014-01-01

Seals and Sealing Handbook, 6th Edition provides comprehensive coverage of sealing technology, bringing together information on all aspects of this area to enable you to make the right sealing choice. This includes detailed coverage on the seals applicable to static, rotary and reciprocating applications, the best materials to use in your sealing systems, and the legislature and regulations that may impact your sealing choices. Updated in line with current trends this updated reference provides the theory necessary for you to select the most appropriate seals for the job and with its 'Failur

Entry-Control Systems Handbook

International Nuclear Information System (INIS)

1978-09-01

The function of an entry-control system in a total Physical Protection System is to allow the movement of authorized personnel and material through normal access routes, yet detect and delay unauthorized movement of personnel and material from uncontrolled areas. The ten chapters of this handbook cover: introduction, credentials, personnel identity verification systems, special nuclear materials monitors, metal detectors, explosives sensors, package search systems, criteria for selection of entry-control equipment, machine-aided manual entry-control systems, and automated entry-control systems. A system example and its cost are included as an appendix

Handbook of radiation shielding data

International Nuclear Information System (INIS)

Courtney, J.C.

1976-07-01

This handbook is a compilation of data on units, conversion factors, geometric considerations, sources of radiation, and the attenuation of photons, neutrons, and charged particles. It also includes related topics in health physics. Data are presented in tabular and graphical form with sufficient narrative for a least first-approximation solutions to a variety of problems in nuclear radiation protection. Members of the radiation shielding community contributed the information in this document from unclassified and uncopyrighted sources, as referenced

Handbook of luminescent semiconductor materials

CERN Document Server

Bergman, Leah

2011-01-01

Photoluminescence spectroscopy is an important approach for examining the optical interactions in semiconductors and optical devices with the goal of gaining insight into material properties. With contributions from researchers at the forefront of this field, Handbook of Luminescent Semiconductor Materials explores the use of this technique to study semiconductor materials in a variety of applications, including solid-state lighting, solar energy conversion, optical devices, and biological imaging. After introducing basic semiconductor theory and photoluminescence principles, the book focuses

The handbook of artificial intelligence

CERN Document Server

Barr, Avron

1982-01-01

The Handbook of Artificial Intelligence, Volume II focuses on the improvements in artificial intelligence (AI) and its increasing applications, including programming languages, intelligent CAI systems, and the employment of AI in medicine, science, and education. The book first elaborates on programming languages for AI research and applications-oriented AI research. Discussions cover scientific applications, teiresias, applications in chemistry, dependencies and assumptions, AI programming-language features, and LISP. The manuscript then examines applications-oriented AI research in medicine

The Crc protein inhibits the production of polyhydroxyalkanoates in Pseudomonas putida under balanced carbon/nitrogen growth conditions.

Science.gov (United States)

La Rosa, Ruggero; de la Peña, Fernando; Prieto, María Axiliadora; Rojo, Fernando

2014-01-01

Pseudomonas putida synthesizes polyhydroxyalkanoates (PHAs) as storage compounds. PHA synthesis is more active when the carbon source is in excess and the nitrogen source is limiting, but can also occur at a lower rate under balanced carbon/nitrogen ratios. This work shows that PHA synthesis is controlled by the Crc global regulator, a protein that optimizes carbon metabolism by inhibiting the expression of genes involved in the use of non-preferred carbon sources. Crc acts post-transcriptionally. The mRNAs of target genes contain characteristic catabolite activity (CA) motifs near the ribosome binding site. Sequences resembling CA motifs can be predicted for the phaC1 gene, which codes for a PHA polymerase, and for phaI and phaF, which encode proteins associated to PHA granules. Our results show that Crc inhibits the translation of phaC1 mRNA, but not that of phaI or phaF, reducing the amount of PHA accumulated in the cell. Crc inhibited PHA synthesis during exponential growth in media containing a balanced carbon/nitrogen ratio. No inhibition was seen when the carbon/nitrogen ratio was imbalanced. This extends the role of Crc beyond that of controlling the hierarchical utilization of carbon sources and provides a link between PHA synthesis and the global regulatory networks controlling carbon flow. © 2013 Society for Applied Microbiology and John Wiley & Sons Ltd.

Iowa Family Day Care Handbook. Second Edition.

Science.gov (United States)

Pinsky, Dorothy; And Others

The Iowa Family Day Care Handbook is designed as an aid for persons entering the business of providing home day care as well as for those persons already in the field. Topics include advantages and disadvantages of family day care for children, parents and providers; getting started in family day care; and a list and description of records that…

Materials handbook for fusion energy systems

Science.gov (United States)

Davis, J. W.; Marchbanks, M. F.

A materials data book for use in the design and analysis of components and systems in near term experimental and commercial reactor concepts has been created by the Office of Fusion Energy. The handbook is known as the Materials Handbook for Fusion Energy Systems (MHFES) and is available to all organizations actively involved in fusion related research or system designs. Distribution of the MHFES and its data pages is handled by the Hanford Engineering Development Laboratory (HEDL), while its direction and content is handled by McDonnell Douglas Astronautics Company — St. Louis (MDAC-STL). The MHFES differs from other handbooks in that its format is geared more to the designer and structural analyst than to the materials scientist or materials engineer. The format that is used organizes the handbook by subsystems or components rather than material. Within each subsystem is information pertaining to material selection, specific material properties, and comments or recommendations on treatment of data. Since its inception a little more than a year ago, over 80 copies have been distributed to over 28 organizations consisting of national laboratories, universities, and private industries.

Greater Sudbury fuel efficient driving handbook

Energy Technology Data Exchange (ETDEWEB)

NONE

2009-12-15

Reducing the amount of fuel that people use for personal driving saves money, improves local air quality, and reduces personal contributions to climate change. This handbook was developed to be used as a tool for a fuel efficient driving pilot program in Greater Sudbury in 2009-2010. Specifically, the purpose of the handbook was to provide greater Sudbury drivers with information on how to drive and maintain their personal vehicles in order to maximize fuel efficiency. The handbook also provides tips for purchasing fuel efficient vehicles. It outlines the benefits of fuel maximization, with particular reference to reducing contributions to climate change; reducing emissions of air pollutants; safe driving; and money savings. Some tips for efficient driving are to avoid aggressive driving; use cruise control; plan trips; and remove excess weight. Tips for efficient winter driving are to avoid idling to warm up the engine; use a block heater; remove snow and ice; use snow tires; and check tire pressure. The importance of car maintenance and tire pressure was emphasized. The handbook also explains how fuel consumption ratings are developed by vehicle manufacturers. refs., figs.

The translational repressor Crc controls the Pseudomonas putida benzoate and alkane catabolic pathways using a multi-tier regulation strategy.

Science.gov (United States)

Hernández-Arranz, Sofía; Moreno, Renata; Rojo, Fernando

2013-01-01

Metabolically versatile bacteria usually perceive aromatic compounds and hydrocarbons as non-preferred carbon sources, and their assimilation is inhibited if more preferable substrates are available. This is achieved via catabolite repression. In Pseudomonas putida, the expression of the genes allowing the assimilation of benzoate and n-alkanes is strongly inhibited by catabolite repression, a process controlled by the translational repressor Crc. Crc binds to and inhibits the translation of benR and alkS mRNAs, which encode the transcriptional activators that induce the expression of the benzoate and alkane degradation genes respectively. However, sequences similar to those recognized by Crc in benR and alkS mRNAs exist as well in the translation initiation regions of the mRNA of several structural genes of the benzoate and alkane pathways, which suggests that Crc may also regulate their translation. The present results show that some of these sites are functional, and that Crc inhibits the induction of both pathways by limiting not only the translation of their transcriptional activators, but also that of genes coding for the first enzyme in each pathway. Crc may also inhibit the translation of a gene involved in benzoate uptake. This multi-tier approach probably ensures the rapid regulation of pathway genes, minimizing the assimilation of non-preferred substrates when better options are available. A survey of possible Crc sites in the mRNAs of genes associated with other catabolic pathways suggested that targeting substrate uptake, pathway induction and/or pathway enzymes may be a common strategy to control the assimilation of non-preferred compounds. © 2012 Society for Applied Microbiology and Blackwell Publishing Ltd.

The "Interval Walking in Colorectal Cancer" (I-WALK-CRC) study: Design, methods and recruitment results of a randomized controlled feasibility trial.

Science.gov (United States)

Banck-Petersen, Anna; Olsen, Cecilie K; Djurhuus, Sissal S; Herrstedt, Anita; Thorsen-Streit, Sarah; Ried-Larsen, Mathias; Østerlind, Kell; Osterkamp, Jens; Krarup, Peter-Martin; Vistisen, Kirsten; Mosgaard, Camilla S; Pedersen, Bente K; Højman, Pernille; Christensen, Jesper F

2018-03-01

Low physical activity level is associated with poor prognosis in patients with colorectal cancer (CRC). To increase physical activity, technology-based platforms are emerging and provide intriguing opportunities to prescribe and monitor active lifestyle interventions. The "Interval Walking in Colorectal Cancer"(I-WALK-CRC) study explores the feasibility and efficacy a home-based interval-walking intervention delivered by a smart-phone application in order to improve cardio-metabolic health profile among CRC survivors. The aim of the present report is to describe the design, methods and recruitment results of the I-WALK-CRC study.Methods/Results: The I-WALK-CRC study is a randomized controlled trial designed to evaluate the feasibility and efficacy of a home-based interval walking intervention compared to a waiting-list control group for physiological and patient-reported outcomes. Patients who had completed surgery for local stage disease and patients who had completed surgery and any adjuvant chemotherapy for locally advanced stage disease were eligible for inclusion. Between October 1st , 2015, and February 1st , 2017, 136 inquiries were recorded; 83 patients were eligible for enrollment, and 42 patients accepted participation. Age and employment status were associated with participation, as participants were significantly younger (60.5 vs 70.8 years, P CRC survivors was feasible but we aim to better the recruitment rate in future studies. Further, the study clearly favored younger participants. The I-WALK-CRC study will provide important information regarding feasibility and efficacy of a home-based walking exercise program in CRC survivors.

Materials and Reliability Handbook for Semiconductor Optical and Electron Devices

CERN Document Server

Pearton, Stephen

2013-01-01

Materials and Reliability Handbook for Semiconductor Optical and Electron Devices provides comprehensive coverage of reliability procedures and approaches for electron and photonic devices. These include lasers and high speed electronics used in cell phones, satellites, data transmission systems and displays. Lifetime predictions for compound semiconductor devices are notoriously inaccurate due to the absence of standard protocols. Manufacturers have relied on extrapolation back to room temperature of accelerated testing at elevated temperature. This technique fails for scaled, high current density devices. Device failure is driven by electric field or current mechanisms or low activation energy processes that are masked by other mechanisms at high temperature. The Handbook addresses reliability engineering for III-V devices, including materials and electrical characterization, reliability testing, and electronic characterization. These are used to develop new simulation technologies for device operation and ...

The β-catenin E3 ubiquitin ligase SIAH-1 is regulated by CSN5/JAB1 in CRC cells.

Science.gov (United States)

Jumpertz, Sandra; Hennes, Thomas; Asare, Yaw; Vervoorts, Jörg; Bernhagen, Jürgen; Schütz, Anke K

2014-09-01

COP9 signalosome subunit 5 (CSN5) plays a decisive role in cellular processes such as cell cycle regulation and apoptosis via promoting protein degradation, gene transcription, and nuclear export. CSN5 regulates cullin-RING-E3 ligase (CRL) activity through its deNEDDylase function. It is overexpressed in several tumor entities, but its role in colorectal cancer (CRC) is poorly understood. Wnt/β-catenin signaling is aberrant in most CRC cells, resulting in increased levels of oncogenic β-catenin and thus tumor progression. Under physiological conditions, β-catenin levels are tightly regulated by continuous proteasomal degradation. We recently showed that knockdown of CSN5 in model and CRC cells results in decreased (phospho)-β-catenin levels. Reduced β-catenin levels were associated with an attenuated proliferation rate of different CRC cell types after CSN5 knockdown. The canonical Wnt pathway involves degradation of β-catenin by a β-TrCP1-containing E3 ligase, but is mostly non-functional in CRC cells. We thus hypothesized that alternative β-catenin degradation mediated by SIAH-1 (seven in absentia homolog-1), is responsible for the effect of CSN5 on β-catenin signaling in CRC cells. We found that SIAH-1 plays an essential role in β-catenin degradation in HCT116 CRC cells and that CSN5 affects β-catenin target gene expression in these cells. Of note, CSN5 affected SIAH-1 mRNA and SIAH-1 protein levels. Moreover, β-catenin and SIAH-1 form protein complexes with CSN5 in HCT116 cells. Lastly, we demonstrate that CSN5 promotes SIAH-1 degradation in HCT116 and SW480 cells and that this is associated with its deNEDDylase activity. In conclusion, we have identified a CSN5/β-catenin/SIAH-1 interaction network that might control β-catenin degradation in CRC cells. Copyright © 2014 Elsevier Inc. All rights reserved.

Handbook of high-level radioactive waste transportation

International Nuclear Information System (INIS)

Sattler, L.R.

1992-10-01

The High-Level Radioactive Waste Transportation Handbook serves as a reference to which state officials and members of the general public may turn for information on radioactive waste transportation and on the federal government's system for transporting this waste under the Civilian Radioactive Waste Management Program. The Handbook condenses and updates information contained in the Midwestern High-Level Radioactive Waste Transportation Primer. It is intended primarily to assist legislators who, in the future, may be called upon to enact legislation pertaining to the transportation of radioactive waste through their jurisdictions. The Handbook is divided into two sections. The first section places the federal government's program for transporting radioactive waste in context. It provides background information on nuclear waste production in the United States and traces the emergence of federal policy for disposing of radioactive waste. The second section covers the history of radioactive waste transportation; summarizes major pieces of legislation pertaining to the transportation of radioactive waste; and provides an overview of the radioactive waste transportation program developed by the US Department of Energy (DOE). To supplement this information, a summary of pertinent federal and state legislation and a glossary of terms are included as appendices, as is a list of publications produced by the Midwestern Office of The Council of State Governments (CSG-MW) as part of the Midwestern High-Level Radioactive Waste Transportation Project

DOE handbook table-top needs analysis

Energy Technology Data Exchange (ETDEWEB)

NONE

1996-03-01

Purpose of this handbook is to establish guidelines for training personnel in developing training for operation, maintenance, and technical support personnel at DOE nuclear facilities. Information from this handbook can be used to conduct needs analysis as the information and methods apply. Operating contractors are encouraged to use good practices selectively in developing or improving programs to meet the specific needs of their facility.

2012 Aerospace Medical Certification Statistical Handbook

Science.gov (United States)

2013-12-01

2012 Aerospace Medical Certification Statistical Handbook Valerie J. Skaggs Ann I. Norris Civil Aerospace Medical Institute Federal Aviation...Certification Statistical Handbook December 2013 6. Performing Organization Code 7. Author(s) 8. Performing Organization Report No. Skaggs VJ, Norris AI 9...2.57 Hayfever 14,477 2.49 Asthma 12,558 2.16 Other general heart pathology (abnormal ECG, open heart surgery, etc.). Wolff-Parkinson-White syndrome

Assessing Religious Orientations: Replication and Validation of the Commitment-Reflectivity Circumplex (CRC Model

Directory of Open Access Journals (Sweden)

Steven L. Isaak

2017-09-01

Full Text Available The Commitment-Reflectivity Circumplex (CRC model is a structural model of religious orientation that was designed to help organize and clarify measurement of foundational aspect of religiousness. The current study successfully replicated the CRC model using multidimensional scaling, and further evaluated the reliability, structure, and validity of their measures in both a university student sample (Study 1 and a nationally representative sample (Study 2. All 10 subscales of the Circumplex Religious Orientation Inventory (CROI demonstrated good reliability across both samples. A two-week test-retest of the CROI showed that the subscales are stable over time. A confirmatory factor analysis of the CROI in the representative adult sample demonstrated good model fit. Finally, the CROI’s validity was examined in relation to the Intrinsic, Extrinsic and Quest measures. Overall, the CROI appears to clarify much of the ambiguity inherent in the established scales by breaking down what were very broad orientations into very specific suborientations. The results suggest that the CRC model is applicable for diverse populations of adults. In addition, the CROI appears to be construct valid with good structural and psychometric properties across all 10 subscales.

The nanobiotechnology handbook

CERN Document Server

Xie, Yubing

2012-01-01

A thorough overview of nanobiotechnology and its place in advances in applied science and engineering, The Nanobiotechnology Handbook combines contributions from physics, bioorganic and bioinorganic chemistry, molecular and cellular biology, materials science, and medicine as well as from mechanical, electrical, chemical, and biomedical engineering to address the full scope of current and future developments. World-class experts discuss the role of nanobiotechnology in bioanalysis, biomolecular and biomedical nanotechnology, biosensors, biocatalysis and biofuel, and education and workforce development. It includes a companion CD that contains all figures in the book. The book begins with discussions of biomimetic nanotechnology, including a comprehensive overview of DNA nanostructure and DNA-inspired nanotechnology, aptamer-functionalized nanomaterials as artificial antibodies, artificial enzymes, molecular motors, and RNA structures and RNA-inspired nanotechnology. It shows how nanotechnology can be inspired...

Handbook of relativistic quantum chemistry

Energy Technology Data Exchange (ETDEWEB)

Liu, Wenjian (ed.) [Peking Univ., Beijing (China). Center for Computational Science and Engineering

2017-03-01

This handbook focuses on the foundations of relativistic quantum mechanics and addresses a number of fundamental issues never covered before in a book. For instance: How can many-body theory be combined with quantum electrodynamics? How can quantum electrodynamics be interfaced with relativistic quantum chemistry? What is the most appropriate relativistic many-electron Hamiltonian? How can we achieve relativistic explicit correlation? How can we formulate relativistic properties? - just to name a few. Since relativistic quantum chemistry is an integral component of computational chemistry, this handbook also supplements the ''Handbook of Computational Chemistry''. Generally speaking, it aims to establish the 'big picture' of relativistic molecular quantum mechanics as the union of quantum electrodynamics and relativistic quantum chemistry. Accordingly, it provides an accessible introduction for readers new to the field, presents advanced methodologies for experts, and discusses possible future perspectives, helping readers understand when/how to apply/develop the methodologies.

The Routledge Handbook of Scandinavian Politics

DEFF Research Database (Denmark)

Scandinavian politics today through a series of cutting-edge chapters. It will be a key reference point both for advanced-level students developing knowledge about the subject, as well as researchers producing new material in the area and beyond. It brings geographical scope and depth, with comparative...... chapters contributed by experts across the region. Methodologically and theoretically pluralistic, the handbook is in itself a reflection of the field of political science in Scandinavia and the diversity of the issues covered in the volume. The Routledge Handbook of Scandinavian Politics......The Routledge Handbook of Scandinavian Politics is a comprehensive overview of Scandinavian politics provided by leading experts in the field and covering the polity, the politics and the policy of Scandinavia. Coherently structured with a multi-level thematic approach, it explains and details...

The role of RCAS1 as a biomarker in diagnosing CRC and monitoring tumor recurrence and metastasis.

Science.gov (United States)

Han, Su-xia; Wang, Jing; Wang, Li-juan; Jin, Gui-hua; Ying, Xia; He, Chen-chen; Guo, Xi-jing; Zhang, Jian-ying; Zhang, Ying; Zhu, Qing

2014-06-01

Receptor-binding cancer antigen expressed on SiSo cells (RCAS1) plays an important role in tumor progression by helping tumor cell to escape from host immunological surveillance or modifying the characteristics of connective tissue around. RCAS1 may appropriately reflect the development and prognosis of tumor. In the study, we sought to identify the clinical significance of RCAS1 in colorectal cancer (CRC) diagnosis and tumor recurrence monitoring. Immunohistochemistry (IHC) with tissue array slides was preformed to analyze RCAS1 protein expression in CRC, colorectal polyps, and normal colon tissues. RCAS1 levels in colorectal cancer were significantly higher than those in colorectal polyps and normal colon tissues (PCRC are significantly higher than in healthy controls and polyps (PCRC was 82.1 %, which was higher than carcinoembryonic antigen (CEA). Especially in CEA-negative cases, the sensitivity of RCAS1 was 88.2 %. Finally, CRC patients who were followed up showed a serum RCAS1 level which significantly decreased after surgery (PCRC diagnosis but also useful for monitoring tumor recurrence. RCAS1 might be a supplementary serological marker for CRC.

Welding processes handbook

CERN Document Server

Weman, Klas

2011-01-01

Offers an introduction to the range of available welding technologies. This title includes chapters on individual techniques that cover principles, equipment, consumables and key quality issues. It includes material on such topics as the basics of electricity in welding, arc physics, and distortion, and the weldability of particular metals.$bThe first edition of Welding processes handbook established itself as a standard introduction and guide to the main welding technologies and their applications. This new edition has been substantially revised and extended to reflect the latest developments. After an initial introduction, the book first reviews gas welding before discussing the fundamentals of arc welding, including arc physics and power sources. It then discusses the range of arc welding techniques including TIG, plasma, MIG/MAG, MMA and submerged arc welding. Further chapters cover a range of other important welding technologies such as resistance and laser welding, as well as the use of welding techniqu...

IAEA-IFRAM joint development of nuclear plant aging management handbooks

International Nuclear Information System (INIS)

Yeji Kim, II Soon Hwang

2015-01-01

As attentions to the beyond design basis accident have increased following Fukushima accident, the importance of aging management for key system, structure and components of nuclear power plant (NPP) also has been emerged as the key factor for safety and reliability of NPPs. The diverse experiences can serve as the foundation for aging management processes that has major trust in the understanding of materials degradation mechanisms. IAEA and IFRAM have collaborated to produce the nuclear plant aging management handbook in order to help entry-level engineers and graduate students understand big pictures. As the number of old NPPs and new-comer countries have increased, sharing experiences and accumulated knowledge from existing nuclear industries has become increasingly important. From this point of view, the handbook has been completed for publication by IAEA which assembled a panel of international experts to integrate the vast body of background knowledge regarding aging mechanism and the extensive know-hows of expertsinto a primer handbook. The next step is to actively utilize the IAEA handbook to produce its web version. In order to reach the ultimate purpose of nuclear safety culture of IAEA, information the handbook should be made easily accessible ana understandable. In this regards, the conversion of IFRAM handbook to web version is being planned. Careful considerations about how to restructure the content and how to reflect opinions from experts and readers are needed. In addition, this handbook can be extended to a training program for maintenance managers, vendors, research organizations and regulators to assist them in their work on aging management in operating NPPs. Through these two aspects, this IFRAM handbook on aging management of NPPs will support of NPP staff both new-comer and established countries. This paper introduces the purpose, approach, structure, content of already completed IAEA handbook and the status and plan for IFRAM Web-handbook

Teaching Development of Foundation Environmental Science Course Using Undergraduate Handbook of Buriram Rajabhat University

Directory of Open Access Journals (Sweden)

Kuntida Thammamrat

2017-06-01

Full Text Available The present study is an attempt to apply the handbook as a tool for teaching foundation of environmental science. The aims of this investigation were 1 to develop a course handbook that fills the standard criteria of 80/80 2 to compare mean derived from pretest and posttest scores 3 to compare student’s attitude toward environmental science from the pretest and posttest scores and 4 to compare student’s environmental scientific skills prior to and after using a study handbook. The key informants were 56 students drawn from 1st- year students of Environmental Science Department of Buriram Rajabhat University in 2558 (B.E academic year. Four instruments of data collection were constructed including 1 the course handbook 2 test of student’s basic knowledge on environmental science, 3 the test of student’s attitude toward environmental science, and 4 the test of student’s environmental scientific skills. The statistics analysis in this study comprised frequency percentage, mean, standard deviation and dependent t – test, which were of used for examining the hypothesis. The findings of this investigation revealed that 1 the efficiency of the handbook entitled “Foundation of environmental science” met the criteria of 80/80 in all aspects with value 83.93/91.81 2 the scores derived from student’s posttest is higher than pretest with .05 statistical significant difference 3 teaching through the handbook enhanced the level of student attitude toward environmental science with .05 statistical significant difference and 4 the environmental scientific skills of the students learning through the handbook are significantly higher than before, at .05 level.

Handbook of nanomedicine

CERN Document Server

Jain, Kewal K

2012-01-01

In its updated and reorganized second edition, this handbook captures the latest advances in nanomedicine applied to researching the pathomechanism of disease, refining molecular diagnostics, and aiding in the discovery, development, and delivery of drugs.

Nutrition for Athletes. A Handbook for Coaches.

Science.gov (United States)

American Association for Health, Physical Education, and Recreation, Washington, DC.

This handbook contains nutritional information for athletic coaches and others who provide this information and guidance to high school and college students. The purposes of the handbook are to review briefly the content of a sound basic diet and to analyze theories and practices that would relate to nutrition and athletic performance. The…

Handbook of Qualitative Research in Communication Disorders

Science.gov (United States)

Ball, Martin J., Ed.; Müller, Nicole, Ed.; Nelson, Ryan L., Ed.

2013-01-01

This volume provides a comprehensive and in-depth handbook of qualitative research in the field of communication disorders. It introduces and illustrates the wide range of qualitative paradigms that have been used in recent years to investigate various aspects of communication disorders. The first part of the Handbook introduces in some detail the…

Handbook of hydraulic fluid technology

CERN Document Server

Totten, George E

2011-01-01

""The Handbook of Hydraulic Fluid Technology"" serves as the foremost resource for designing hydraulic systems and for selecting hydraulic fluids used in engineering applications. Featuring new illustrations, data tables, as well as practical examples, this second edition is updated with essential information on the latest hydraulic fluids and testing methods. The detailed text facilitates unparalleled understanding of the total hydraulic system, including important hardware, fluid properties, and hydraulic lubricants. Written by worldwide experts, the book also offers a rigorous overview of h

APS beamline standard components handbook, Version 1.3

International Nuclear Information System (INIS)

Hahn, U.; Shu, D.; Kuzay, T.M.

1993-02-01

This Handbook in its current version (1.3) contains descriptions, specifications, and preliminary engineering design drawings for many of the standard components. The design status and schedules have been provided wherever possible. In the near future, the APS plans to update engineering drawings of identified standard beamline components and complete the Handbook. The completed version of this Handbook will become available to both the CATs and potential vendors. Use of standard components should result in major cost reductions for CATs in the areas of beamline design and construction

Handbook of Research on Environmental Taxation

OpenAIRE

2012-01-01

The Handbook of Research on Environmental Taxation captures the state of the art of research on environmental taxation. Written by 36 specialists in environmental taxation from 16 countries, it takes an interdisciplinary and international approach, focusing on issues that are universal to using taxation to achieve environmental goals.The Handbook explores the conceptual foundations of environmental taxation, essential elements for designing environmental tax measures, factors that influence t...

NR2F2 inhibits Smad7 expression and promotes TGF-β-dependent epithelial-mesenchymal transition of CRC via transactivation of miR-21.

Science.gov (United States)

Wang, Hao; Nie, Lei; Wu, Lei; Liu, Qiufang; Guo, Xueyan

2017-03-25

Metastasis is one of the most decisive factors influencing CRC patient prognosis and current studies suggest that a molecular mechanism known as EMT broadly regulates cancer metastasis. NR2F2 is a key molecule in the development of CRC, but the roles and underlying mechanisms of NR2F2 in TGF-β induced EMT in CRC remain largely unknown. In the current study, we were interested to examine the role of NR2F2 in the TGF-β-induced EMT in CRC. Here, we found NR2F2 was upregulated in CRC cells and promotes TGF-β-induced EMT in CRC. Using comparative miRNA profiling TGF-β pre-treated CRC cells in which NR2F2 had been knocked down with that of control cells, we identified miR-21 as a commonly downregulated miRNA in HT29 cells treated with TGF-β and NR2F2 siRNA, and its downregulation inhibiting migration and invasion of CRC cells. Moreover, we found NR2F2 could transcriptional activated miR-21 expression by binding to miR-21 promoter in HT29 by ChIP and luciferase assay. In the last, our data demonstrated that Smad7 was the direct target of miR-21 in CRC cells. Thus, NR2F2 could promote TGF-β-induced EMT and inhibit Smad7 expression via transactivation of miR-21, and NR2F2 may be a new common therapeutic target for CRC. Copyright © 2017 Elsevier Inc. All rights reserved.

The Crc protein participates in down-regulation of the Lon gene to promote rhamnolipid production and rhl quorum sensing in Pseudomonas aeruginosa.

Science.gov (United States)

Yang, Nana; Ding, Shuting; Chen, Feifei; Zhang, Xue; Xia, Yongjie; Di, Hongxia; Cao, Qiao; Deng, Xin; Wu, Min; Wong, Catherine C L; Tian, Xiao-Xu; Yang, Cai-Guang; Zhao, Jing; Lan, Lefu

2015-05-01

Rhamnolipid acts as a virulence factor during Pseudomonas aeruginosa infection. Here, we show that deletion of the catabolite repression control (crc) gene in P. aeruginosa leads to a rhamnolipid-negative phenotype. This effect is mediated by the down-regulation of rhl quorum sensing (QS). We discover that a disruption of the gene encoding the Lon protease entirely offsets the effect of crc deletion on the production of both rhamnolipid and rhl QS signal C4-HSL. Crc is unable to bind lon mRNA in vitro in the absence of the RNA chaperon Hfq, while Crc contributes to Hfq-mediated repression of the lon gene expression at a posttranscriptional level. Deletion of crc, which results in up-regulation of lon, significantly reduces the in vivo stability and abundance of the RhlI protein that synthesizes C4-HSL, causing the attenuation of rhl QS. Lon is also capable of degrading the RhlI protein in vitro. In addition, constitutive expression of rhlI suppresses the defects of the crc deletion mutant in rhamnolipid, C4-HSL and virulence on lettuce leaves. This study therefore uncovers a novel posttranscriptional regulatory cascade, Crc-Hfq/Lon/RhlI, for the regulation of rhamnolipid production and rhl QS in P. aeruginosa. © 2015 John Wiley & Sons Ltd.

FAA statistical handbook of aviation, calendar year 1988

Science.gov (United States)

1988-08-15

The FAA Statistical Handbook of Aviation is published annually by the Federal Aviation Administration (FAA). The handbook is provided here in MS Excel. format as downloadable files and as text tables that can be viewed in PDF format. The prime purpos...

The Family Support Group (FSG) Leaders’ Handbook

Science.gov (United States)

2000-04-01

family guide. Fort Hood, TX: Author. Granovsky , N. (1998). Family Support Group leader basic handbook (Operation READY). Alexandria, VA: U. S...Readiness and Financial Planning " (22.3 minutes). Granovsky , N. (1998). Family Support Group Leader Basic Handbook (Operation READY). Alexandria

approche algorithme génétique

African Journals Online (AJOL)

Structure / acentric factor relationship of alcohols and phenols: genetic ... descriptors of geometrical type selected by genetic algorithm, among more than 1600 ..... Practical handbook of genetic algorithms: Applications Volume I; CRC Press.

High reflectance Cr/C multilayer at 250 eV for soft X-ray polarimetry

Energy Technology Data Exchange (ETDEWEB)

Wen, Mingwu; Jiang, Li; Zhang, Zhong; Huang, Qiushi [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); Wang, Zhanshan, E-mail: wangzs@tongji.edu.cn [MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering (IPOE), School of Physics Science and Engineering, Tongji University, Shanghai 200092 (China); She, Rui; Feng, Hua [Department of Engineering Physics, Tsinghua University, Beijing (China); Wang, Hongchang [Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE (United Kingdom)

2015-10-01

X-ray reflection near 45° via multilayer mirrors can be used for astronomical polarization measurements. A Cr/C multilayer mirror (designed for X-ray polarimetry at 250 eV), with a period thickness of 3.86 nm and a bi-layer number of 100, was fabricated using direct current magnetron sputtering. Grazing incidence X-ray reflectometry at 8 keV and transmission electron microscopy were used to investigate the multilayer structure. Different models were introduced to fit the hard X-ray reflectivity curve, which indicates that the layer thickness of two materials slightly drifts from the bottom to the top of the stack. Both the chromium and carbon layers are amorphous with asymmetric interfaces, while the Cr-on-C interface is slightly wider. Based on the good quality of the multilayer structure, a high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV at a grazing incidence angle of 40.7°. The fabricated Cr/C multilayer mirror exhibits high reflectivity and polarization levels in the energy region of 240 eV–260 eV. - Highlights: • We fabricated Cr/C multilayer with 3.8 nm d-spacing. • X-ray reflectometry was used to determine the exact structure of Cr/C multilayer. • A high reflectivity of 21.8% for the s-polarized light was obtained at 250 eV. • Both Cr and C were found to be amorphous with slightly asymmetric interfaces. • A 4-layer model was used to fit and explain the results.

Student Employee Handbook. EP-2008-09-136-MSFC

Science.gov (United States)

National Aeronautics and Space Administration (NASA), 2007

2007-01-01

This student employee handbook offers tips on planning, design process, and presentation of a student Lunar Nautics project. Each section includes mission, task, challenge, and guide questions. With the activities presented, students will learn to design a Lunar Lander, Lunar Miner, and Lunar Base; investigate the geography and geology of the moon…

Handbook of mechanical engineering terms

CERN Document Server

Ramalingam, KK

2009-01-01

About the Book: The Handbook of Mechanical Engineering terms contains short, precise definitions of about four thousand terms. These terms have been collected from different sources, edited and grouped under twenty six parts and given alphabetically under each part for easy reference. The book will be a source of guidance and help to the students, staff and practising engineers in understanding and updating the subject matter. Contents: The Handbook of Mechanical Engineering terms contains short, precise definitions of about four thousand terms. These terms have been collected from differ

NASA Risk-Informed Decision Making Handbook

Science.gov (United States)

Dezfuli, Homayoon; Stamatelatos, Michael; Maggio, Gaspare; Everett, Christopher; Youngblood, Robert; Rutledge, Peter; Benjamin, Allan; Williams, Rodney; Smith, Curtis; Guarro, Sergio

2010-01-01

This handbook provides guidance for conducting risk-informed decision making in the context of NASA risk management (RM), with a focus on the types of direction-setting key decisions that are characteristic of the NASA program and project life cycles, and which produce derived requirements in accordance with existing systems engineering practices that flow down through the NASA organizational hierarchy. The guidance in this handbook is not meant to be prescriptive. Instead, it is meant to be general enough, and contain a sufficient diversity of examples, to enable the reader to adapt the methods as needed to the particular decision problems that he or she faces. The handbook highlights major issues to consider when making decisions in the presence of potentially significant uncertainty, so that the user is better able to recognize and avoid pitfalls that might otherwise be experienced.

Stop the Bullying: A Handbook for Schools.

Science.gov (United States)

Rigby, Ken

Noting that bullying in school is a growing concern in Australian communities, this handbook draws upon a 10-year study of bullying in Australian schools and is designed to help educators find out what is happening in their school and develop sound anti-bullying policies. The handbook also provides guidance in working effectively with students to…

Handbook of integral equations

CERN Document Server

Polyanin, Andrei D

2008-01-01

This handbook contains over 2,500 integral equations with solutions as well as analytical and numerical methods for solving linear and nonlinear equations. It explores Volterra, Fredholm, WienerHopf, Hammerstein, Uryson, and other equations that arise in mathematics, physics, engineering, the sciences, and economics. This second edition includes new chapters on mixed multidimensional equations and methods of integral equations for ODEs and PDEs, along with over 400 new equations with exact solutions. With many examples added for illustrative purposes, it presents new material on Volterra, Fredholm, singular, hypersingular, dual, and nonlinear integral equations, integral transforms, and special functions.

Handbook for sound engineers

CERN Document Server

Ballou, Glen

2013-01-01

Handbook for Sound Engineers is the most comprehensive reference available for audio engineers. All audio topics are explored: if you work on anything related to audio you should not be without this book! The 4th edition of this trusted reference has been updated to reflect changes in the industry since the publication of the 3rd edition in 2002 -- including new technologies like software-based recording systems such as Pro Tools and Sound Forge; digital recording using MP3, wave files and others; mobile audio devices such as iPods and MP3 players. Over 40 topic

Handbook of enumerative combinatorics

CERN Document Server

Bona, Miklos

2015-01-01

Presenting the state of the art, the Handbook of Enumerative Combinatorics brings together the work of today's most prominent researchers. The contributors survey the methods of combinatorial enumeration along with the most frequent applications of these methods.This important new work is edited by Miklós Bóna of the University of Florida where he is a member of the Academy of Distinguished Teaching Scholars. He received his Ph.D. in mathematics at Massachusetts Institute of Technology in 1997. Miklós is the author of four books and more than 65 research articles, including the award-winning C

Hyapproval : final handbook for approval of hydrogen refuelling stations

NARCIS (Netherlands)

Wurster, R.; Landinger, H.; Machens, C.; Allidières, L.; Molag, M.; Barron, J.; Reijalt, M.; Hill, H.J.

2006-01-01

HyApproval is an EC co-financed Specific Targeted Research Project (STREP) to develop a Handbook facilitating the approval of Hydrogen Refuelling Stations (HRS). The project, started in October 2005, will be performed over 24 months by a balanced partnership including 25 partners from industry, SMEs

The handbook of optical communication networks

CERN Document Server

Ilyas, Mohammad

2003-01-01

The Handbook of Optical Communication Networks presents comprehensive, up-to-date technical information on integrated, state-of-the-art optical networks. Beginning with an in-depth intoduction to the field, top international authorities explore every major aspect of optical networks, from basic concepts to research grade material. Their discussions cover all of the essential topics, including protocols, resource management, routing and wavelength assignment in WDM networks, connection management, survivability, enabling technologies, and future trends.

Handbook for designing roadways for the aging population.

Science.gov (United States)

2014-06-01

The original Older Driver Highway Design Handbook was published by FHWA in 1998 (FHWA-RD-97-135). The : 2nd edition, titled Highway Design Handbook for Older Drivers and Pedestrians (FHWA-RD-01-103) was published in : 2001. This 3rd edition, under a ...

Handbook of practical X-ray fluorescence analysis

International Nuclear Information System (INIS)

Beckhoff, B.; Wedell, R.; Wolff, H.

2006-01-01

X-ray fluorescence analysis (XRF) is a reliable multi-elemental and nondestructive analytical method widely used in research and industrial applications. This practical handbook provides self-contained modules featuring XRF instrumentation, quantification methods, and most of the current applications. The broad spectrum of topics is due to the efforts of a large number of authors from a variety of different types of institutions such as universities, research institutes, and companies. The book gives a survey of the theoretical fundamentals, analytical instrumentation, software for data processing, various excitation regimes including gracing incidents and microfocus measurements, quantitative analysis, applications in routine and micro analysis, mineralogy, biology, medicine, criminal investigations, archeology, metallurgy, abrasion, microelectronics, environmental air and water analysis. It gives the basic knowledge on this technique, information on analytical equipment and guides the reader to the various applications. This practical handbook is intended as a resource for graduate students, research scientists, and industrial users. (orig.)

Handbook of practical X-ray fluorescence analysis

Energy Technology Data Exchange (ETDEWEB)

Beckhoff, B. [Physikalisch-Technische Bundesanstalt, Berlin (Germany). X-ray Spectrometry; Kanngiesser, B. [Technische Univ. Berlin (Germany). Inst. fuer Atomare Physik und Fachdidaktik; Langhoff, N. [IfG-Institute for Scientific Instruments GmbH, Berlin (Germany); Wedell, R.; Wolff, H. (eds.) [Institut fuer Angewandte Photonik e.V., Berlin (Germany)

2006-07-01

X-ray fluorescence analysis (XRF) is a reliable multi-elemental and nondestructive analytical method widely used in research and industrial applications. This practical handbook provides self-contained modules featuring XRF instrumentation, quantification methods, and most of the current applications. The broad spectrum of topics is due to the efforts of a large number of authors from a variety of different types of institutions such as universities, research institutes, and companies. The book gives a survey of the theoretical fundamentals, analytical instrumentation, software for data processing, various excitation regimes including gracing incidents and microfocus measurements, quantitative analysis, applications in routine and micro analysis, mineralogy, biology, medicine, criminal investigations, archeology, metallurgy, abrasion, microelectronics, environmental air and water analysis. It gives the basic knowledge on this technique, information on analytical equipment and guides the reader to the various applications. This practical handbook is intended as a resource for graduate students, research scientists, and industrial users. (orig.)

Hsa-miR-875-5p exerts tumor suppressor function through down-regulation of EGFR in colorectal carcinoma (CRC).

Science.gov (United States)

Zhang, Tiening; Cai, Xun; Li, Qi; Xue, Peng; Chen, Zhixiao; Dong, Xiao; Xue, Ying

2016-07-05

Hsa-miRNA-875-5p (miR-875-5p) has recently been discovered to have anticancer efficacy in different organs. However, the role of miR-875-5p on colorectal carcinoma (CRC) is still ambiguous. In this study, we investigated the role of miR-875-5p on the development of CRC. The results indicated that miR-875-5p was significantly down-regulated in primary tumor tissues and very low levels were found in CRC cell lines. Ectopic expression of miR-875-5p in CRC cell lines significantly suppressed cell growth as evidenced by cell viability assay, colony formation assay and BrdU staining, through inhibition of cyclin D1, cyclin D2, CDK4 and up-regulation of p57(Kip2) and p21(Waf1/Cip1). In addition, miR-875-5p induced apoptosis, as indicated by concomitantly with up-regulation of key apoptosis protein cleaved caspase-3, and down-regulation of anti-apoptosis protein Bcl2. Moreover, miR-875-5p inhibited cellular migration and invasiveness through inhibition of matrix metalloproteinases (MMP)-7 and MMP-9. Further, oncogene EGFR was revealed to be a putative target of miR-875-5p, which was inversely correlated with miR-875-5p expression in CRC. Taken together, our results demonstrated that miR-875-5p played a pivotal role on CRC through inhibiting cell proliferation, migration, invasion, and promoting apoptosis by targeting oncogenic EGFR.

Referencing handbook: OSCOLA

OpenAIRE

Williams, Helen

2016-01-01

University of Lincoln approved guide to OSCOLA referencing. Providing guidelines on how to reference UK, EU and International primary sources of law and secondary sources. The handbook provides examples and annotated diagrams to help you reference sources in the OSCOLA style.

Randomized controlled dissemination study of community-to-clinic navigation to promote CRC screening: Study design and implications.

Science.gov (United States)

Larkey, Linda; Szalacha, Laura; Herman, Patricia; Gonzalez, Julie; Menon, Usha

2017-02-01

Regular screening facilitates early diagnosis of colorectal cancer (CRC) and reduction of CRC morbidity and mortality. Screening rates for minorities and low-income populations remain suboptimal. Provider referral for CRC screening is one of the strongest predictors of adherence, but referrals are unlikely among those who have no clinic home (common among poor and minority populations). This group randomized controlled study will test the effectiveness of an evidence based tailored messaging intervention in a community-to-clinic navigation context compared to no navigation. Multicultural, underinsured individuals from community sites will be randomized (by site) to receive CRC screening education only, or education plus navigation. In Phase I, those randomized to education plus navigation will be guided to make a clinic appointment to receive a provider referral for CRC screening. Patients attending clinic appointments will continue to receive navigation until screened (Phase II) regardless of initial arm assignment. We hypothesize that those receiving education plus navigation will be more likely to attend clinic appointments (H1) and show higher rates of screening (H2) compared to those receiving education only. Phase I group assignment will be used as a control variable in analysis of screening follow-through in Phase II. Costs per screening achieved will be evaluated for each condition and the RE-AIM framework will be used to examine dissemination results. The novelty of our study design is the translational dissemination model that will allow us to assess the real-world application of an efficacious intervention previously tested in a randomized controlled trial. Copyright © 2016. Published by Elsevier Inc.

AINSE's 40th anniversary conference. Conference handbook

International Nuclear Information System (INIS)

1998-01-01

Highlights of 40 years of activity of the Australian Institute of Nuclear Science and Engineering (AINSE) were the main focus of this conference. Topics covered include nuclear physics, plasma physics, radiation chemistry, radiation biology, neutron diffraction, nuclear techniques of analysis and other relevant aspects of nuclear science and technology. The conference handbook contains the summaries of the 78 papers and posters presented and the list of participants

MicroRNA-466 (miR-466) functions as a tumor suppressor and prognostic factor in colorectal cancer (CRC).

Science.gov (United States)

Tong, Feng; Ying, Youhua; Pan, Haihua; Zhao, Wei; Li, Hongchen; Zhan, Xiaoli

2018-01-17

MicroRNAs (miRNAs) have an important role in the regulation of tumor development and metastasis. In this study, we investigated the clinical and prognostic value as well as biological function of miR-466 in colorectal cancer (CRC). Tumor and adjacent healthy tissues were obtained from 100 patients diagnosed with CRC. miR-466 expression was determined by quantitative reverse transcription polymerase chain reaction (qRT-PCR). mRNA and protein levels of cyclin D1, apoptosis regulator BAX (BAX), and matrix metalloproteinase-2 (MMP-2) were analyzed by qRT-PCR and Western blot, respectively, in SW-620 CRC cells transfected with miR-466 mimics or negative control miRNA. Effects of miR-466 on SW-620 cell proliferation, cell cycle and apoptosis, and invasion were investigated using CCK-8 assay, flow cytometry and Transwell assay, respectively. miR-466 expression was significantly downregulated in tumor tissues compared to matched adjacent non-tumor tissues. Low expression of miR-466 was significantly correlated with the tumor size, Tumor Node Metastasis stage, lymph node metastasis, and distant metastasis. The overall survival of CRC patients with low miR-466 expression was significantly shorter compared to high-miR-466 expression group (log-rank test: p = 0.0103). Multivariate analysis revealed that low miR-466 expression was associated with poor prognosis in CRC patients. The ectopic expression of miR-466 suppressed cell proliferation and migration/invasion, as well as induced G0/G1 arrest and apoptosis in SW-620 cells. Moreover, the ectopic expression of miR-466 decreased the expression of cyclin D1 and MMP-2, but increased BAX expression in SW-620 cells. In conclusion, our findings demonstrated that miR-466 functions as a suppressor miRNA in CRC and may be used as a prognostic factor in these patients.

Third international handbook of mathematics education

CERN Document Server

Bishop, Alan; Keitel, Christine; Kilpatrick, Jeremy; Leung, Frederick

2013-01-01

This entirely new Third International Handbook of Mathematics Education comprises 31 chapters which have been written by a total of 84 different authors representing 26 nations, each a recognized expert in the field.   Comprised of four sections: Social, Political and Cultural Dimensions in Mathematics Education; Mathematics Education as a Field of Study; Technology in the Mathematics Curriculum; and International Perspectives on Mathematics Education, this Third Handbook offers essential reading for all persons interested in the future of mathematics education. The authors present challenging international perspectives on the history of mathematics education, current issues, and future directions.   What makes this Handbook unique is its structure. Each section covers past, present and future aspects of mathematics education.   The first chapter in each section identifies and analyzes historical antecedents The “middle” chapters draw attention to present-day key issues and themes The final chapter in ...

Why Wait Until Our Community Gets Cancer?: Exploring CRC Screening Barriers and Facilitators in the Spanish-Speaking Community in North Carolina.

Science.gov (United States)

Martens, Christa E; Crutchfield, Trisha M; Laping, Jane L; Perreras, Lexie; Reuland, Daniel S; Cubillos, Laura; Pignone, Michael P; Wheeler, Stephanie B

2016-12-01

Colorectal cancer (CRC) is a leading cause of death among Hispanics in the United States. Despite the benefits of CRC screening, many Hispanics are not being screened. Using a combined methodology of focus groups and discrete choice experiment (DCE) surveys, the objectives for this research were as follows: (1) to improve understanding of preferences regarding potential CRC screening program characteristics, and (2) to improve understanding of the barriers and facilitators around CRC screening with the Hispanic, immigrant community in North Carolina. Four gender-stratified focus groups were conducted and DCE surveys were administered to 38 Spanish-speaking individuals across four counties in North Carolina. In-depth content analysis was used to examine the focus group data; descriptive analyses and mean attribute importance scores for cost of screening and follow-up care, travel time, and test options were calculated from DCE data. Data analyses showed that this population has a strong interest in CRC screening but experience barriers such as lack of access to resources, cost uncertainty, and stigma. Some of these barriers are unique to their cultural experiences in the United States, such as an expressed lack of tailored CRC information. Based on the DCE, cost variables were more important than testing options or travel time. This study suggests that Hispanics may have a general awareness of and interest in CRC screening, but multiple barriers prevent them from getting screened. Special attention should be given to designing culturally and linguistically appropriate programs to improve access to healthcare resources, insurance, and associated costs among Hispanics.

Development of a quality assurance handbook to improve educational courses in Africa.

Science.gov (United States)

Nabwera, Helen M; Purnell, Sue; Bates, Imelda

2008-12-18

The attainment of the Millennium Development Goals has been hampered by the lack of skilled and well-informed health care workers in many developing countries. The departure of health care workers from developing countries is one of the most important causes. One of the motivations for leaving is that developed countries have well-established health care systems that incorporate continuing medical education, which enables health care workers to develop their skills and knowledge base. This provision is lacking in many developing countries. The provision of higher-education programmes of good quality within developing countries therefore, contributes to building capacity of the health care workforce in these countries. The Liverpool School of Tropical Medicine is involved in delivering off-site higher educational programmes to health care workers in Africa. Our colleagues at one of these sites requested a guide to help them ensure that their professional development courses met international educational standards. We reviewed published literature that outlines the principles of quality assurance in higher education from various institutions worldwide. Using this information, we designed a handbook that outlines the quality assurance principles in a simple and practical way. This was intended to enable institutions, even in developing countries, to adapt these principles in accordance with their local resource capacity. We subsequently piloted this handbook at one of the sites in Ghana. The feedback from this aided the development of the handbook. The development of this handbook was participatory in nature. The handbook addresses six main themes that are the minimum requirements that a higher education course should incorporate to ensure that it meets internationally recognized standards. These include: recruitment and admissions, course design and delivery, student assessments, approval and review processes, support for students and staff training and welfare. It

Family history assessment for colorectal cancer (CRC) risk analysis - comparison of diagram- and questionnaire-based web interfaces.

Science.gov (United States)

Schultz, Michael; Seo, Steven Bohwan; Holt, Alec; Regenbrecht, Holger

2015-11-18

Colorectal cancer (CRC) has a high incidence, especially in New Zealand. The reasons for this are unknown. While most cancers develop sporadically, a positive family history, determined by the number and age at diagnosis of affected first and second degree relatives with CRC is one of the major factors, which may increase an individual's lifetime risk. Before a patient can be enrolled in a surveillance program a detailed assessment and documentation of the family history is important but time consuming and often inaccurate. The documentation is usually paper-based. Our aim was therefore to develop and validate the usability and efficacy of a web-based family history assessment tool for CRC suitable for the general population. The tool was also to calculate the risk and make a recommendation for surveillance. Two versions of an electronic assessment tool, diagram-based and questionnaire-based, were developed with the risk analysis and recommendations for surveillance based on the New Zealand Guidelines Group recommendations. Accuracy of our tool was tested prior to the study by comparing risk calculations based on family history by experienced gastroenterologists with the electronic assessment. The general public, visiting a local science fair were asked to use and comment on the usability of the two interfaces. Ninety people assessed and commented on the two interfaces. Both interfaces were effective in assessing the risk to develop CRC through their familial history for CRC. However, the questionnaire-based interface performed with significantly better satisfaction (p = 0.001) than the diagram-based interface. There was no difference in efficacy though. We conclude that a web-based questionnaire tool can assist in the accurate documentation and analysis of the family history relevant to determine the individual risk of CRC based on local guidelines. The calculator is now implemented and assessable through the web-page of a local charity for colorectal cancer

Job Sharing: General Information. A Handbook for Employers.

Science.gov (United States)

Olmsted, Barney

Arranging work time in new and flexible ways has been a topic of growing interest for the past ten years. This handbook for employers explains one way in which jobs can be made more flexible--job sharing. It discusses ways that work hours can be shared with potential benefits for employer and employees. Topics discussed include definition of job…

Kitchen Magic: A Nutrition and Cooking Activities Handbook.

Science.gov (United States)

Crist, Mary Jo; And Others

This handbook on nutrition and cooking is one of a series written especially for parents and other caregivers. Contents include: (1) the importance of nutrition, (2) the four basic food groups in terms of serving size, menu planning, and major nutrients, (3) ways to build healthy attitudes toward food, (4) unsafe foods which have the potential to…

[Handbook for the preparation of evidence-based documents. Tools derived from scientific knowledge].

Science.gov (United States)

Carrión-Camacho, M R; Martínez-Brocca, M A; Paneque-Sánchez-Toscano, I; Valencia-Martín, R; Palomino-García, A; Muñoz-Durán, C; Tamayo-López, M J; González-Eiris-Delgado, C; Otero-Candelera, R; Ortega-Ruiz, F; Sobrino-Márquez, J M; Jiménez-García-Bóveda, R; Fernández-Quero, M; Campos-Pareja, A M

2013-01-01

This handbook is intended to be an accessible, easy-to-consult guide to help professionals produce or adapt Evidence-Based Documents. Such documents will help standardize both clinical practice and decision-making, the quality always being monitored in such a way that established references are complied with. Evidence-Based Health Care Committee, a member of "Virgen del Rocío" University Hospital quality structure, proposed the preparation of a handbook to produce Evidence-Based Documents including: a description of products, characteristics, qualities, uses, methodology of production, and application scope of every one of them. The handbook consists of seven Evidence-Based tools, one chapter on critical analysis methodology of scientific literature, one chapter with internet resources, and some appendices with different assessment tools. This Handbook provides general practitioners with a great opportunity to improve quality and as a guideline to standardize clinical healthcare, and managers with a strategy to promote and encourage the development of documents in an effort to reduce clinical practice variability, as well as giving patients the opportunity of taking part in planning their own care. Copyright © 2011 SECA. Published by Elsevier Espana. All rights reserved.

Transit manager's handbook.

Science.gov (United States)

2011-09-01

This handbook provides an overview of public transit in Iowa and how to do business with the Iowa Department of Transportation (Iowa DOT) Office of Public Transit (OPT). It is intended to be a tool to assist transit managers navigate through the many...

Quality assurance handbook for measurement laboratories

International Nuclear Information System (INIS)

Delvin, W.L.

1984-10-01

This handbook provides guidance in the application of quality assurance to measurement activities. It is intended to help those persons making measurements in applying quality assurance to their work activities by showing how laboratory practices and quality assurance requirements are integrated to provide control within those activities. The use of the guidance found in this handbook should help provide consistency in the interpretation of quality assurance requirements across all types of measurement laboratories. This handbook also can assist quality assurance personnel in understanding the relationships between laboratory practices and quality assurance requirements. The handbook is composed of three chapters and several appendices. Basic guidance is provided by the three chapters. In Chapter 1, the role of quality assurance in obtaining quality data and the importance of such data are discussed. Chapter 2 presents the elements of laboratory quality assurance in terms of practices that can be used in controlling work activities to assure the acquisition of quality data. Chapter 3 discusses the implementation of laboratory quality assurance. The appendices provide supplemental information to give the users a better understanding of the following: what is quality assurance; why quality assurance is required; where quality assurance requirements come from; how those requirements are interpreted for application to laboratory operations; how the elements of laboratory quality assurance relate to various laboratory activities; and how a quality assurance program can be developed

Handbook of parameter values for the prediction of radionuclide transfer to wildlife

Energy Technology Data Exchange (ETDEWEB)

NONE

2014-06-15

This handbook provides generic parameter values for estimating the transfer of radionuclides from environmental media to wildlife for the purpose of assessing potential radiation exposure under equilibrium conditions. These data are intended for use where site specific data are either not available or not required, and to parameterize generic assessment models. They are based on a comprehensive review of the available literature, including many Russian language publications that have not previously been available in English. The publication addresses the limitations of the parameter values and the applicability of data. Some general background information on the assessment of potential impacts of radioactive releases on wildlife is also included. It complements the existing handbook in the same IAEA series with parameter to assess the radiological impact to humans.

Dynamical systems and linear algebra

OpenAIRE

Colonius, Fritz (Prof.)

2007-01-01

Dynamical systems and linear algebra / F. Colonius, W. Kliemann. - In: Handbook of linear algebra / ed. by Leslie Hogben. - Boca Raton : Chapman & Hall/CRC, 2007. - S. 56,1-56,22. - (Discrete mathematics and its applications)

Unusual radioresistance of nitrogen-fixing cultures of Anabaena ...

Indian Academy of Sciences (India)

Prakash

Atlas R M 2004 Handbook of microbiological media; third edition. (Florida: CRC Press) ... nitrogen-fixation, and nodularin production by two Baltic sea cyanobacteria ... Sharma A 1998 Mycotoxins: risk evaluation and management in radiation ...

Multiple Hfq-Crc target sites are required to impose catabolite repression on (methyl)phenol metabolism in Pseudomonas putida CF600.

Science.gov (United States)

Wirebrand, Lisa; Madhushani, Anjana W K; Irie, Yasuhiko; Shingler, Victoria

2018-01-01

The dmp-system encoded on the IncP-2 pVI150 plasmid of Pseudomonas putida CF600 confers the ability to assimilate (methyl)phenols. Regulation of the dmp-genes is subject to sophisticated control, which includes global regulatory input to subvert expression of the pathway in the presence of preferred carbon sources. Previously we have shown that in P. putida, translational inhibition exerted by the carbon repression control protein Crc operates hand-in-hand with the RNA chaperon protein Hfq to reduce translation of the DmpR regulator of the Dmp-pathway. Here, we show that Crc and Hfq co-target four additional sites to form riboprotein complexes within the proximity of the translational initiation sites of genes encoding the first two steps of the Dmp-pathway to mediate two-layered control in the face of selection of preferred substrates. Furthermore, we present evidence that Crc plays a hitherto unsuspected role in maintaining the pVI150 plasmid within a bacterial population, which has implications for (methyl)phenol degradation and a wide variety of other physiological processes encoded by the IncP-2 group of Pseudomonas-specific mega-plasmids. © 2017 Society for Applied Microbiology and John Wiley & Sons Ltd.

Premium Efficiency Motor Selection and Application Guide – A Handbook for Industry

Energy Technology Data Exchange (ETDEWEB)

Gilbert A. McCoy and John G. Douglass

2014-02-01

This handbook informs new motor purchase decisions by identifying energy and cost savings that can come from replacing motors with premium efficiency units. The handbook provides an overview of current motor use in the industrial sector, including the development of motor efficiency standards, currently available and emerging advanced efficiency motor technologies, and guidance on how to evaluate motor efficiency opportunities. It also several tips on getting the most out of industrial motors, such as how to avoid adverse motor interactions with electronic adjustable speed drives and how to ensure efficiency gains are not lost to undervoltage operation or excessive voltage unbalance.

Newnes short wave listening handbook

CERN Document Server

Pritchard, Joe

2013-01-01

Newnes Short Wave Listening Handbook is a guide for starting up in short wave listening (SWL). The book is comprised of 15 chapters that discuss the basics and fundamental concepts of short wave radio listening. The coverage of the text includes electrical principles; types of signals that can be heard in the radio spectrum; and using computers in SWL. The book also covers SWL equipment, such as receivers, converters, and circuits. The text will be of great use to individuals who want to get into short wave listening.

Data envelopment analysis a handbook of modeling internal structure and network

CERN Document Server

Cook, Wade D

2014-01-01

This comprehensive handbook on state-of-the-art topics in DEA modeling of internal structures and networks presents work by leading researchers who share their results on subjects including additive efficiency decomposition and slacks-based network DEA.

HANDBOOK - Environmental Assessment of Construction Products - An introduction to test mehtods and other procedures related to CE-marking

DEFF Research Database (Denmark)

Wahlstrom, Margareta; Laine-Ylyjoki, Jutta; Rautiainen, Liisa

2009-01-01

regulatory limit values with test results. The starting point in this handbook is the situation where there might be a potential for a release to soil and water during the intended use of a product. This handbook presents aspects that are especially important for manufactures of construction products...... Harmonised Standards and European Technical Approvals describe methods for testing of construction products and specify the conditions for CE marking of construction products. This handbook presents an overview of the technical, regulatory and administrative framework within which CE marking of construction...... products takes place and offers guidance on the selection of test methods for assessment of release of regulated dangerous substances from construction products to soil, surface water and groundwater. The handbook includes information on how test results can be used, e.g. by regulators when comparing...

Decision support handbook for recovery of contaminated inhabited areas

Energy Technology Data Exchange (ETDEWEB)

Andersson, K.G. (Technical Univ. of Denmark, Risoe National Lab. for Sustainable Energy, Roskilde (Denmark)); Ammann, M. (STUK, Helsinki (Finland)); Backe, S. (IFE, Kjeller (Norway)); Rosen, K. (Swedish Univ. of Agricultural Sciences, Uppsala (Sweden))

2008-07-15

The handbook is aimed at providing Nordic decision-makers and their expert advisors with required background material for the development of an optimised, operational preparedness for situations where airborne radioactive matter has contaminated a Nordic inhabited area. The focus is on the mitigation of long-term problems. It should be stressed that the information given in the handbook is comprehensive, and many details require careful consideration well in time before implementation of countermeasures in a specific area. Training sessions are therefore recommended. The handbook describes the current relevant Nordic preparedness (dissemination routes) in detail, and suggests methods for measurement of contamination and prognoses of resultant doses, and data for evaluation of countermeasures and associated waste management options. A number of non-technical aspects of contamination in inhabited areas, and of countermeasures for its mitigation, are discussed, and a series of recommendations on the application of all the handbook data in a holistic countermeasure strategy are given. A part of the handbook development has been a dialogue with end-user representatives in each of the Nordic countries, to focus the work of the specific needs of the users. (au)

Decision support handbook for recovery of contaminated inhabited areas

International Nuclear Information System (INIS)

Andersson, K.G.; Ammann, M.; Backe, S.; Rosen, K.

2008-07-01

The handbook is aimed at providing Nordic decision-makers and their expert advisors with required background material for the development of an optimised, operational preparedness for situations where airborne radioactive matter has contaminated a Nordic inhabited area. The focus is on the mitigation of long-term problems. It should be stressed that the information given in the handbook is comprehensive, and many details require careful consideration well in time before implementation of countermeasures in a specific area. Training sessions are therefore recommended. The handbook describes the current relevant Nordic preparedness (dissemination routes) in detail, and suggests methods for measurement of contamination and prognoses of resultant doses, and data for evaluation of countermeasures and associated waste management options. A number of non-technical aspects of contamination in inhabited areas, and of countermeasures for its mitigation, are discussed, and a series of recommendations on the application of all the handbook data in a holistic countermeasure strategy are given. A part of the handbook development has been a dialogue with end-user representatives in each of the Nordic countries, to focus the work of the specific needs of the users. (au)

The international handbook of space technology

CERN Document Server

Badescu, Viorel

2014-01-01

This comprehensive handbook provides an overview of space technology and a holistic understanding of the system-of-systems that is a modern spacecraft. With a foreword by Elon Musk, CEO and CTO of SpaceX, and contributions from globally leading agency experts from NASA, ESA, JAXA, and CNES, as well as European and North American academics and industrialists, this handbook, as well as giving an interdisciplinary overview, offers, through individual self-contained chapters, more detailed understanding of specific fields, ranging through: ·         Launch systems, structures, power, thermal, communications, propulsion, and software, to ·         entry, descent and landing, ground segment, robotics, and data systems, to ·         technology management, legal and regulatory issues, and project management. This handbook is an equally invaluable asset to those on a career path towards the space industry as it is to those already within the industry.

Photovoltaic engineering handbook

Energy Technology Data Exchange (ETDEWEB)

Lasnier, F; Ang, T G [Asian Institute of Technolgoy, Bangkok (TH)

1990-01-01

The Photovoltaic Engineering Handbook is a comprehensive 'nuts and bolts' guide to photovoltaic technology and systems engineering aimed at engineers and designers in the field. It is the first book to look closely at the practical problems involved in evaluating and setting up a PV power system. The authors' comprehensive insight into the different procedures and decisions that a designer needs to make. The book is unique in its coverage and the technical information is presented in a concise and simple way to enable engineers from a wide range of backgrounds to initiate, assess, analyse and design a PV system. Energy planners making decisions on the most appropriate system for specific needs will also benefit from reading this book. Topics covered include technological processes, including solar cell technology, the photovoltaic generator, photovoltaic systems engineering; characterization and testing methods, sizing procedure; economic analysis and instrumentation. (author).

Handbook of supernovae

CERN Document Server

Murdin, Paul

2017-01-01

This reference work gathers all of the latest research in the supernova field areas to create a definitive source book on supernovae, their remnants and related topics. It includes each distinct subdiscipline, including stellar types, progenitors, stellar evolution, nucleosynthesis of elements, supernova types, neutron stars and pulsars, black holes, swept up interstellar matter, cosmic rays, neutrinos from supernovae, supernova observations in different wavelengths, interstellar molecules and dust. While there is a great deal of primary and specialist literature on supernovae, with a great many scientific groups around the world focusing on the phenomenon and related subdisciplines, nothing else presents an overall survey. This handbook closes that gap at last. As a comprehensive and balanced collection that presents the current state of knowledge in the broad field of supernovae, this is to be used as a basis for further work and study by graduate students, astronomers and astrophysicists working in close/r...

Handbook for structural analysis of radioactive material transport casks

International Nuclear Information System (INIS)

Ikushima, Takeshi

1991-04-01

This paper described structural analysis method of radioactive material transport casks for use of a handbook of safety analysis and evaluation. Safety analysis conditions, computer codes for analyses and stress evaluation method are also involved in the handbook. (author)

SEL/Project Language. Level II, Kindergarten, Teacher's Handbook.

Science.gov (United States)

Valladares, Ann E.; Lynch, Helen C.

The Teacher's Handbook is part of the publication series of the Southeastern Education Laboratory/Project Language (SEL/PL), an 8-year language-centered program designed to alleviate the language deficiencies of disadvantaged children between the ages of four and eleven. For teachers utilizing SEL/PL, the Handbook provides a research summary and…

Barriers to CRC Screening among Latino Adults in Pennsylvania: ACCN Results

Science.gov (United States)

Garcia-Dominic, Oralia; Lengerich, Eugene J.; Wray, Linda A.; Parrott, Roxanne; Aumiller, Betsy; Kluhsman, Brenda; Renderos, Carlos; Dignan, Mark

2012-01-01

Objectives: To describe knowledge of and barriers to colorectal cancer (CRC) screening by sex and geography among Latino adults in Pennsylvania. Methods: Eighty-two Latinos greater than 50 years old engaged in one of 8 focus groups. Focus groups consisted of 4 components. Focus group data were audiotaped, transcribed, and grouped into thematic…

20. AINSE plasma science and technology conference. Conference handbook

International Nuclear Information System (INIS)

1995-01-01

The 20th AINSE plasma science and technology conference was held at Flinders University of South Australia on 13-14 February 1995. Topics under discussion included plasma physics studies, current status of rotamak devices, plasma processing and material studies. The handbook contains the conference program, 54 abstracts and a list of participants

20. AINSE plasma science and technology conference. Conference handbook

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-12-31

The 20th AINSE plasma science and technology conference was held at Flinders University of South Australia on 13-14 February 1995. Topics under discussion included plasma physics studies, current status of rotamak devices, plasma processing and material studies. The handbook contains the conference program, 54 abstracts and a list of participants.

Mechanical engineers' handbook, manufacturing and management

CERN Document Server

Kutz, Myer

2015-01-01

Full coverage of manufacturing and management in mechanicalengineering Mechanical Engineers' Handbook, Fourth Edition provides aquick guide to specialized areas that engineers may encounter intheir work, providing access to the basics of each and pointingtoward trusted resources for further reading, if needed. The book'saccessible information offers discussions, examples, and analysesof the topics covered, rather than the straight data, formulas, andcalculations found in other handbooks. No single engineer can be aspecialist in all areas that they are called upon to work in. It'sa discipline

Hereditary Colorectal Cancer (CRC Program in Latvia

Directory of Open Access Journals (Sweden)

Irmejs Arvids

2003-12-01

Full Text Available Abstract Introduction The aim of the study is to evaluate the incidence and phenotype - genotype characteristics of hereditary colorectal cancer syndromes in Latvia in order to develop the basis of clinical management for patients and their relatives affected by these syndromes. Materials and methods From 02/1999-09/2002 in several hospitals in Latvia cancer family histories were collected from 865 patients with CRC. In families suspected of having a history consistent with a hereditary colorectal cancer syndrome, DNA testing for MLH1, MSH2 and MSH6 genes was performed. In addition immunohistochemical (IH examination of the normal and cancer tissue from large bowel tumors for MSH2 and MSH6 protein expression was performed prior to DNA analysis. Results From the 865 CRC cases only 3 (0.35% pedigrees fulfilled the Amsterdam II criteria of Hereditary Nonpolyposis Colorectal Cancer (HNPCC and 15 cases (1.73% were suspected of HNPCC. In 69 cases (8% with a cancer family aggregation (CFA were identified. Thus far 27 IH analyses have been performed and in 3 cancers homogenous lack of MSH2 or MSH6 protein expression was found. In one of these cases a mutation in MSH6 was identified. In 18 patients suspected of HNPCC or of matching the Amsterdam II criteria, denaturing high performance liquid chromatography (DHPLC followed by DNA sequencing of any heteroduplexes of the 35 exons comprising both MLH1 and MSH2 was performed revealing 3 mutations. For all of kindreds diagnosed definitively or with a high probability of being an HNPCC family appropriate recommendations concerning prophylactic measures, surveillance and treatment were provided in written form. Conclusions Existing pedigree/clinical data suggest that in Latvia the frequency of HNPCC is around 2% of consecutive colorectal cancer patients. It is crucial that genetic counseling is an integral part of cancer family syndrome management.

Handbook of Social Media for Researchers and Supervisors

OpenAIRE

Minocha, Shailey; Petre, Marian

2012-01-01

The goal of this handbook is to assist researchers and their supervisors to adopt and use social media tools in the service of their research, and, in particular, in engaging in the discourse of research. The handbook presents an innovative suite of resources for developing and maintaining a social media strategy for research dialogues.

Handbook of electroporation

CERN Document Server

2017-01-01

This major reference work is a one-shot knowledge base on electroporation and the use of pulsed electric fields of high intensity and their use in biology, medicine, biotechnology, and food and environmental technologies. The Handbook offers a widespread and well-structured compilation of 156 chapters ranging from the foundations to applications in industry and hospital. It is edited and written by most prominent researchers in the field. With regular updates and growing in its volume it is suitable for academic readers and researchers regardless of their disciplinary expertise, and will also be accessible to students and serious general readers. The Handbook's 276 authors have established scholarly credentials and come from a wide range of disciplines. This is crucially important in a highly interdisciplinary field of electroporation and the use of pulsed electric fields of high intensity and its applications in different fields from medicine, biology, food proce ssing, agriculture, process engineering, en...

Handbook of SCADA/control systems security

CERN Document Server

Radvanovsky, Robert

2013-01-01

The availability and security of many services we rely upon-including water treatment, electricity, healthcare, transportation, and financial transactions-are routinely put at risk by cyber threats. The Handbook of SCADA/Control Systems Security is a fundamental outline of security concepts, methodologies, and relevant information pertaining to the supervisory control and data acquisition (SCADA) systems and technology that quietly operate in the background of critical utility and industrial facilities worldwide. Divided into five sections, the book examines topics comprising functions within

Planning for Student Assessment: Participant's Handbook. Bilingual Evaluation Technical Assistance, Workshop III.

Science.gov (United States)

California Univ., Los Angeles. Center for the Study of Evaluation.

This participant's handbook is designed to be used in conjunction with a workshop for planning bilingual student assessment. The following materials are included: (1) simulation materials, including descriptions of simulated programs, tests, test manuals, and printouts; (2) checklists, diagrams, and charts illustrating important points of the…

Introduction to 'International Handbook of Criticality Safety Benchmark Experiments'

International Nuclear Information System (INIS)

Komuro, Yuichi

1998-01-01

The Criticality Safety Benchmark Evaluation Project (CSBEP) was initiated in 1992 by the United States Department of Energy. The project quickly became an international effort as scientists from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) is now an official activity of the Organization for Economic Cooperation and Development-Nuclear Energy Agency (OECD-NEA). 'International Handbook of Criticality Safety Benchmark Experiments' was prepared and is updated year by year by the working group of the project. This handbook contains criticality safety benchmark specifications that have been derived from experiments that were performed at various nuclear critical facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculation techniques used. The author briefly introduces the informative handbook and would like to encourage Japanese engineers who are in charge of nuclear criticality safety to use the handbook. (author)

29 CFR 37.64 - What procedures must the Director follow when CRC has completed a post-approval compliance review?

Science.gov (United States)

2010-07-01

... 29 Labor 1 2010-07-01 2010-07-01 true What procedures must the Director follow when CRC has completed a post-approval compliance review? 37.64 Section 37.64 Labor Office of the Secretary of Labor... (WIA) Compliance Procedures § 37.64 What procedures must the Director follow when CRC has completed a...

Handbook of satellite applications

CERN Document Server

Madry, Scott; Camacho-Lara, Sergio

2013-01-01

Top space experts from around the world have collaborated to produce this comprehensive, authoritative, and clearly illustrated reference guide to the fast growing, multi-billion dollar field of satellite applications and space communications. This handbook, done under the auspices of the International Space University based in France, addresses not only system technologies but also examines market dynamics, technical standards and regulatory constraints. The handbook is a completely multi-disciplinary reference book that covers, in an in-depth fashion, the fields of satellite telecommunications, Earth observation, remote sensing, satellite navigation, geographical information systems, and geosynchronous meteorological systems. It covers current practices and designs as well as advanced concepts and future systems. It provides a comparative analysis of the common technologies and design elements for satellite application bus structures, thermal controls, power systems, stabilization techniques, telemetry, com...

NASA systems engineering handbook

Science.gov (United States)

Shishko, Robert; Aster, Robert; Chamberlain, Robert G.; McDuffee, Patrick; Pieniazek, Les; Rowell, Tom; Bain, Beth; Cox, Renee I.; Mooz, Harold; Polaski, Lou

1995-06-01

This handbook brings the fundamental concepts and techniques of systems engineering to NASA personnel in a way that recognizes the nature of NASA systems and environment. It is intended to accompany formal NASA training courses on systems engineering and project management when appropriate, and is designed to be a top-level overview. The concepts were drawn from NASA field center handbooks, NMI's/NHB's, the work of the NASA-wide Systems Engineering Working Group and the Systems Engineering Process Improvement Task team, several non-NASA textbooks and guides, and material from independent systems engineering courses taught to NASA personnel. Five core chapters cover systems engineering fundamentals, the NASA Project Cycle, management issues in systems engineering, systems analysis and modeling, and specialty engineering integration. It is not intended as a directive.

Expression Analysis of Previously Verified Fecal and Plasma Dow-regulated MicroRNAs (miR-4478, 1295-3p, 142-3p and 26a-5p), in FFPE Tissue Samples of CRC Patients.

Science.gov (United States)

Ghanbari, Reza; Rezasoltani, Sama; Hashemi, Javad; Mohamadkhani, Ashraf; Tahmasebifar, Arash; Arefian, Ehsan; Mobarra, Naser; Asadi, Jahanbakhsh; Nazemalhosseini Mojarad, Ehsan; Yazdani, Yaghoub; Knuutila, Sakari; Malekzadeh, Reza

2017-02-01

Colorectal cancer (CRC) is one of the most common causes of cancer-related mortality worldwide. Early diagnosis of this neoplasm is critical and may reduce patients' mortality. MicroRNAs are small non-coding RNA molecules whose expression pattern can be altered in various diseases such as CRC. In this study, we evaluated the expression levels of miR-142-3p, miR-26a-5p (their reduced expression in plasma samples of CRC patients was previously confirmed), miR-4478 and miR-1295-3p (their reduced expression in stool samples of CRC patients was previously confirmed) in tissue samples of CRC patients in comparison to healthy subjects. To achieve this purpose, total RNA including small RNA was extracted from 53 CRC and 35 normal subjects' Formalin-fixed, Paraffin-embedded (FFPE) tissue samples using the miRNeasy FFPE Mini Kit. The expression levels of these four selected miRNAs were measured using quantitative Reverse Transcriptase Polymerase Chain Reaction (qRT-PCR). We found that the expression levels of miR-4478 and miR-1295b-3p (two previously down-regulated fecal miRNAs) were significantly decreased in FFPE samples of CRC patients compared to healthy controls. On the other hand, no significant differences were seen in expression levels of miR-142-3p and miR-26a-5p (two previously down-regulated circulating miRNAs) in FFPE samples between these two groups. Regarding current findings, it may be concluded that to diagnose CRC patients based on the miRNAs approach, stool samples are more likely preferable to plasma samples; nevertheless, additional studies with more samples are needed to confirm the results.

Archaeological Handbook for Establishing Offshore Wind Farms in Sweden. Lillgrund Pilot Project

Energy Technology Data Exchange (ETDEWEB)

Bengtsson, Boel [Bohuslaens Museum, Uddevalla (Sweden)

2008-03-15

The purpose of this handbook is to provide a structured guide for contractors interested in establishing offshore wind farms within Swedish territorial waters and its extended economical zone, in relation to Underwater Cultural Heritage (UCH). It is also applicable to UCH in inland waters. Therefore, this handbook seeks to provide information on; - The management structure of underwater/maritime cultural heritage in Sweden, including institutions and units with maritime antiquarian expertise, - The different types of archaeological remains that can be found around the Swedish coast - in offshore, coastal areas and on the foreshore - which can potentially be affected by offshore wind farm projects, - The laws that underwater archaeological remains are subject to - within the National Maritime Boundary as well as within the contiguous and exclusive economical zones - and the necessary archaeological investigations that need to be considered in order to avoid and/or protect the cultural heritage provided by those remains, - Archaeological standards and methods for assessing and evaluating the potential for finding archaeological remains under water, - The steps that need to be to considered during the planning process of establishing offshore wind farms, and how the contractor and archaeologist can work together in order to make the process more cost effective, and - Considerations for the future. Furthermore, this handbook includes a presentation of archaeological finds made during archaeological surveys in connection with the Lillgrund project. The handbook does not make references to any investigations that may be required in relation to land based archaeological sites other than those which are undertaken close to the shoreline (situated on the foreshore), nor does it consider the visual impact sea-based wind farms might have on cultural heritage

Millimeter-wave spectroscopy of CrC (X(3)Σ(-)) and CrCCH (X̃ (6)Σ(+)): Examining the chromium-carbon bond.

Science.gov (United States)

Min, J; Ziurys, L M

2016-05-14

Pure rotational spectroscopy of the CrC (X(3)Σ(-)) and CrCCH (X̃ (6)Σ(+)) radicals has been conducted using millimeter/sub-millimeter direct absorption methods in the frequency range 225-585 GHz. These species were created in an AC discharge of Cr(CO)6 and either methane or acetylene, diluted in argon. Spectra of the CrCCD were also recorded for the first time using deuterated acetylene as the carbon precursor. Seven rotational transitions of CrC were measured, each consisting of three widely spaced, fine structure components, arising from spin-spin and spin-rotation interactions. Eleven rotational transitions were recorded for CrCCH and five for CrCCD; each transition in these cases was composed of a distinct fine structure sextet. These measurements confirm the respective (3)Σ(-) and (6)Σ(+) ground electronic states of these radicals, as indicated from optical studies. The data were analyzed using a Hund's case (b) Hamiltonian, and rotational, spin-spin, and spin-rotation constants have been accurately determined for all three species. The spectroscopic parameters for CrC were significantly revised from previous optical work, while those for CrCCH are in excellent agreement; completely new constants were established for CrCCD. The chromium-carbon bond length for CrC was calculated to be 1.631 Å, while that in CrCCH was found to be rCr-C = 1.993 Å - significantly longer. This result suggests that a single Cr-C bond is present in CrCCH, preserving the acetylenic structure of the ligand, while a triple bond exists in CrC. Analysis of the spin constants suggests that CrC has a nearby excited (1)Σ(+) state lying ∼16 900 cm(-1) higher in energy, and CrCCH has a (6)Π excited state with E ∼ 4800 cm(-1).

Backbone and stereospecific (13)C methyl Ile (δ1), Leu and Val side-chain chemical shift assignments of Crc.

Science.gov (United States)

Sharma, Rakhi; Sahu, Bhubanananda; Ray, Malay K; Deshmukh, Mandar V

2015-04-01

Carbon catabolite repression (CCR) allows bacteria to selectively assimilate a preferred compound among a mixture of several potential carbon sources, thus boosting growth and economizing the cost of adaptability to variable nutrients in the environment. The RNA-binding catabolite repression control (Crc) protein acts as a global post-transcriptional regulator of CCR in Pseudomonas species. Crc triggers repression by inhibiting the expression of genes involved in transport and catabolism of non-preferred substrates, thus indirectly favoring assimilation of preferred one. We report here a nearly complete backbone and stereospecific (13)C methyl side-chain chemical shift assignments of Ile (δ1), Leu and Val of Crc (~ 31 kDa) from Pseudomonas syringae Lz4W.

Development of a quality assurance handbook to improve educational courses in Africa

Directory of Open Access Journals (Sweden)

Purnell Sue

2008-12-01

Full Text Available Abstract Background The attainment of the Millennium Development Goals has been hampered by the lack of skilled and well-informed health care workers in many developing countries. The departure of health care workers from developing countries is one of the most important causes. One of the motivations for leaving is that developed countries have well-established health care systems that incorporate continuing medical education, which enables health care workers to develop their skills and knowledge base. This provision is lacking in many developing countries. The provision of higher-education programmes of good quality within developing countries therefore, contributes to building capacity of the health care workforce in these countries. Methods The Liverpool School of Tropical Medicine is involved in delivering off-site higher educational programmes to health care workers in Africa. Our colleagues at one of these sites requested a guide to help them ensure that their professional development courses met international educational standards. We reviewed published literature that outlines the principles of quality assurance in higher education from various institutions worldwide. Using this information, we designed a handbook that outlines the quality assurance principles in a simple and practical way. This was intended to enable institutions, even in developing countries, to adapt these principles in accordance with their local resource capacity. We subsequently piloted this handbook at one of the sites in Ghana. The feedback from this aided the development of the handbook. The development of this handbook was participatory in nature. Results The handbook addresses six main themes that are the minimum requirements that a higher education course should incorporate to ensure that it meets internationally recognized standards. These include: recruitment and admissions, course design and delivery, student assessments, approval and review processes

First Handbooks on History of Religion and Comparative Religion Abroad

Directory of Open Access Journals (Sweden)

Barashkov Viktor

2016-01-01

Full Text Available One of the important aspects of institutionalization of the religious studies in 1870– 1910s was the publishing of the fi rst handbooks on history of religion and comparative religion. The aim of the paper is to analyze methods and approaches of religious studies, as they described in these handbooks. The main characteristic of religion for the historians of religion was its universality. The most important methods, according to them, were historical approach, comparative approach, using of the notion «development». It is important, that we deal foremost with the «history of religion» in these handbooks, not with the «history of religions». Primitive religions were usually excluded from these handbooks, because they «have not history». First handbooks on history of religion often were edited in the series of theological handbooks, that’s why Christianity was described in them quite often as «higher» religion. Researches on comparative religion were based upon the history of religion. One of the main principles of comparative religion was that it should not deal with religious values, but only with a comparison of facts. The author concludes that scholars of religion nowadays should not only collect the facts, but also realize projects on the general history (theory of religion.

ICSBEP-2007, International Criticality Safety Benchmark Experiment Handbook

International Nuclear Information System (INIS)

Blair Briggs, J.

2007-01-01

1 - Description: The Critically Safety Benchmark Evaluation Project (CSBEP) was initiated in October of 1992 by the United Sates Department of Energy. The project quickly became an international effort as scientist from other interested countries became involved. The International Criticality Safety Benchmark Evaluation Project (ICSBEP) is now an official activity of the Organization of Economic Cooperation and Development - Nuclear Energy Agency (OECD-NEA). This handbook contains criticality safety benchmark specifications that have been derived from experiments that were performed at various nuclear critical facilities around the world. The benchmark specifications are intended for use by criticality safety engineers to validate calculational techniques used to establish minimum subcritical margins for operations with fissile material. The example calculations presented do not constitute a validation of the codes or cross section data. The work of the ICSBEP is documented as an International Handbook of Evaluated Criticality Safety Benchmark Experiments. Currently, the handbook spans over 42,000 pages and contains 464 evaluations representing 4,092 critical, near-critical, or subcritical configurations and 21 criticality alarm placement/shielding configurations with multiple dose points for each and 46 configurations that have been categorized as fundamental physics measurements that are relevant to criticality safety applications. The handbook is intended for use by criticality safety analysts to perform necessary validations of their calculational techniques and is expected to be a valuable tool for decades to come. The ICSBEP Handbook is available on DVD. You may request a DVD by completing the DVD Request Form on the internet. Access to the Handbook on the Internet requires a password. You may request a password by completing the Password Request Form. The Web address is: http://icsbep.inel.gov/handbook.shtml 2 - Method of solution: Experiments that are found

Demonstration of generic handbooks for assisting in the management of contaminated food production systems and inhabited areas in Europe

DEFF Research Database (Denmark)

Nisbet, A.F.; Andersson, Kasper Grann; Duranova, T.

2010-01-01

Two handbooks have been developed in conjunction with a wide range of stakeholders that provide assistance in the management of contaminated food production systems and inhabited areas following a radiological incident. Emergency centres in Member States not involved in the development...... of these handbooks were invited to take part in demonstration activities to establish whether the handbooks would be useful for the purposes of contingency planning and accident management. Some eight centres took part. Emergency exercises or similar events based on scenarios involving contamination of the foodchain...... and inhabited areas were used. Feedback from all of the demonstrations was positive with constructive criticism given on how to improve the navigation, structure and format of the handbooks. All of the key improvements highlighted during the demonstrations were taken into account and included in version 2...

Springer Handbook of Condensed Matter and Materials Data

CERN Document Server

Martienssen, Werner

2005-01-01

Condensed Matter and Materials Science are two of the most active fields of applied physics, with a stream of discoveries in areas from superconductivity and magnetism to the optical, electronic and mechanical properties of materials. While a huge amount of data has been compiled and spread over numerous reference works, no single volume compiles the most used information. Springer Handbook of Condensed Matter and Materials Data provides a concise compilation of data and functional relationships from the fields of solid-state physics and materials in this 1200-page volume. The data, encapsulated in over 750 tables and 1025 illustrations, have been selected and extracted primarily from the extensive high-quality data collection Landolt-Börnstein and also from other systematic data sources and recent publications of physical and technical property data. Many chapters are authored by Landolt-Börnstein editors, including the editors of this Springer Handbook. Key Topics Fundamental Constants The International S...

Handbook of latent variable and related models

CERN Document Server

Lee, Sik-Yum

2011-01-01

This Handbook covers latent variable models, which are a flexible class of models for modeling multivariate data to explore relationships among observed and latent variables.- Covers a wide class of important models- Models and statistical methods described provide tools for analyzing a wide spectrum of complicated data- Includes illustrative examples with real data sets from business, education, medicine, public health and sociology.- Demonstrates the use of a wide variety of statistical, computational, and mathematical techniques.

Basic Reading Instruction for Students in Automotive Occupations. Student's Handbook.

Science.gov (United States)

General Behavioral Systems, Inc., Torrance, CA.

The basic reading course outlined in this student handbook emphasizes the decoding process. The contents consist of a letter-and-sound spelling chart and 87 course modules which are based on single-letter and letter-combination sounds. Many of the modules include exercises, and some contain reading material. (JM)

Construction project management handbook.

Science.gov (United States)

2012-03-01

The purpose of the FTA Construction Project Management Handbook is to provide guidelines for use by public transit agencies (Agen-cies) undertaking substantial construction projects, either for the first time or with little prior experience with cons...

AINSE`s 40th anniversary conference. Conference handbook

Energy Technology Data Exchange (ETDEWEB)

NONE

1998-12-31

Highlights of 40 years of activity of the Australian Institute of Nuclear Science and Engineering (AINSE) were the main focus of this conference. Topics covered include nuclear physics, plasma physics, radiation chemistry, radiation biology, neutron diffraction, nuclear techniques of analysis and other relevant aspects of nuclear science and technology. The conference handbook contains the summaries of the 78 papers and posters presented and the list of participants

Handbook of Applied Solid State Spectroscopy

CERN Document Server

Vij, D. R

2006-01-01

Solid-State spectroscopy is a burgeoning field with applications in many branches of science, including physics, chemistry, biosciences, surface science, and materials science. Handbook of Applied Solid-State Spectroscopy brings together in one volume information about various spectroscopic techniques that is currently scattered in the literature of these disciplines. This concise yet comprehensive volume covers theory and applications of a broad range of spectroscopies, including NMR, NQR, EPR/ESR, ENDOR, scanning tunneling, acoustic resonance, FTIR, auger electron emission, x-ray photoelectron emission, luminescence, and optical polarization, and more. Emphasis is placed on fundamentals and current methods and procedures, together with the latest applications and developments in the field.

Handbook of hardware/software codesign

CERN Document Server

Teich, Jürgen

2017-01-01

This handbook presents fundamental knowledge on the hardware/software (HW/SW) codesign methodology. Contributing expert authors look at key techniques in the design flow as well as selected codesign tools and design environments, building on basic knowledge to consider the latest techniques. The book enables readers to gain real benefits from the HW/SW codesign methodology through explanations and case studies which demonstrate its usefulness. Readers are invited to follow the progress of design techniques through this work, which assists readers in following current research directions and learning about state-of-the-art techniques. Students and researchers will appreciate the wide spectrum of subjects that belong to the design methodology from this handbook. .

More than Twenty Years of Svensén's Handbook

DEFF Research Database (Denmark)

Pálfi, Loránd-Levente

2010-01-01

The number of real handbooks dealing with lexicography and metalexicography is not, and has never been, impressive. When one looks at comprehensive handbooks and in addition those brought up to date, the number becomes even smaller. Because of this, but also because it has existed for more than 20...

Handbook of Best Practices for Geothermal Drilling

Energy Technology Data Exchange (ETDEWEB)

Finger, John Travis [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Blankenship, Douglas A. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

2012-02-01

This Handbook is a description of the complex process that comprises drilling a geothermal well. The focus of the detailed Chapters covering various aspects of the process (casing design, cementing, logging and instrumentation, etc) is on techniques and hardware that have proven successful in geothermal reservoirs around the world. The Handbook will eventually be linked to the GIA web site, with the hope and expectation that it can be continually updated as new methods are demonstrated or proven.

Introduction: Green Building Handbook

CSIR Research Space (South Africa)

Van Wyk, Llewellyn V

2010-08-01

Full Text Available By recognising the specific environmental challenges facing South Africa, mindful of the government‘s commitment to reducing South Africa‘s Greenhouse gas emissions, and acknowledging the need to build social cohesion, the Green Building Handbook...

Exploring Cryogenic Focused Ion Beam Milling as a Group III-V Device Fabrication Tool

Science.gov (United States)

2013-09-01

boiling, triple , and critical points of the elements” in CRC Handbook of Chemistry and Physics, 92nd ed., Boca Raton, FL: CRC press, 2011-2012, p. 4...The most widely used ion source in FIB instruments is a gallium (Ga) liquid metal ion source (LMIS) [4]. Gallium is attractive as an ion source...Figure 3b. EDS spectra were captured at different points across the patterned region of the room temperature milled sample, as indicated in Figure 4

The Video Handbook.

Science.gov (United States)

1972

In order to provide basic technical and production information for closed-circuit television, the editors have assembled this series of papers. Deisgned as an introductory guide for those entering the field, the handbook covers the basic areas of non-broadcast television. Starting with facilities and equipment the guide outlines the planning and…

Handbook of Memetic Algorithms

CERN Document Server

Cotta, Carlos; Moscato, Pablo

2012-01-01

Memetic Algorithms (MAs) are computational intelligence structures combining multiple and various operators in order to address optimization problems.  The combination and interaction amongst operators evolves and promotes the diffusion of the most successful units and generates an algorithmic behavior which can handle complex objective functions and hard fitness landscapes.   “Handbook of Memetic Algorithms” organizes, in a structured way, all the the most important results in the field of MAs since their earliest definition until now.  A broad review including various algorithmic solutions as well as successful applications is included in this book. Each class of optimization problems, such as constrained optimization, multi-objective optimization, continuous vs combinatorial problems, uncertainties, are analysed separately and, for each problem,  memetic recipes for tackling the difficulties are given with some successful examples. Although this book contains chapters written by multiple authors, ...

Solar cell radiation handbook

Science.gov (United States)

Tada, H. Y.; Carter, J. R., Jr.; Anspaugh, B. E.; Downing, R. G.

1982-01-01

The handbook to predict the degradation of solar cell electrical performance in any given space radiation environment is presented. Solar cell theory, cell manufacturing and how they are modeled mathematically are described. The interaction of energetic charged particles radiation with solar cells is discussed and the concept of 1 MeV equivalent electron fluence is introduced. The space radiation environment is described and methods of calculating equivalent fluences for the space environment are developed. A computer program was written to perform the equivalent fluence calculations and a FORTRAN listing of the program is included. Data detailing the degradation of solar cell electrical parameters as a function of 1 MeV electron fluence are presented.

Suicide Bombing in the COE. DCSINT Handbook No. 1.03

National Research Council Canada - National Science Library

2005-01-01

This handbook is one in a series of supplements to TRADOC DCSINT Handbook No. 1, "A Military Guide to Terrorism in the Twenty-First Century," which is a basic terrorism primer prepared under the direction of the U.S...

Radiance Research Particle Soot/Absorption Photometer Instrument Handbook

Energy Technology Data Exchange (ETDEWEB)

Springston, S. R. [Brookhaven National Lab. (BNL), Upton, NY (United States)

2016-03-01

Radiance Research PSAPs as described in this Handbook are deployed in the second ARM Mobile Facility (AMF2) Aerosol Observing System (AOS), the third ARM Mobile Facility (AMF3) AOS, ENA AOS and Mobile Aerosol Observing System (MAOS)-A. An earlier version of the PSAP is currently operated in the ARM Aerial Facility and at SGP. The older SGP instrument is covered in a separate Handbook.

The health physics and radiological health handbook

International Nuclear Information System (INIS)

Shleien, B.

1992-01-01

This handbook was conceived in order to fill the need of health physics practitioners, technicians, and students for an easy to use, practical handbook containing health physics and radiological health data. While briefer and more specific data sources are sources are available on single subject areas, as are multi-volume compendia, there is no current up-to-date compilation of information useful on a daily basis by the health physicist. Separate abstracts have been prepared for 16 chapters in this book

Handbook of ecotoxicology

Science.gov (United States)

Hoffman, David J.; Rattner, Barnett A.; Burton, G. Allen; Cairns, John

1995-01-01

The Handbook of Ecotoxicology offers 34 chapters with contributions from over 50 selected international experts. The book is divided into four major sections: I. Quantifying and Measuring Ecotoxicological Effects, II. Contaminant Sources and Effects, III. Case Histories and Ecosystem Surveys, and IV. Methods for Making Estimates and Predictability in Ecotoxicology. Concepts and methodology are presented for many types of aquatic and terrestrial ecotoxicity test protocols for both controlled and field assessments. Chapters are offered on such diverse topics as sediment and soil ecotoxicity, landscape indicators, biomonitoring, and use of current bioindicators. The roles of deforestation and global warming, pathogens and disease in ecotoxicology, abiotic factors, urban runoff, predictive ecotoxicology, population modeling, and restoration ecology are discussed. This book was designed to serve as a reference book for students entering the fields of ecotoxicology, aquatic toxicology, terrestrial wildlife toxicology, and other environmental sciences. Many portions of this handbook will serve as a convenient reference text for established investigators, resource managers, and those involved in risk assessment and risk management within regulatory agencies and the private sector.

Information handbook on independent spent fuel storage installations

International Nuclear Information System (INIS)

Raddatz, M.G.; Waters, M.D.

1996-12-01

In this information handbook, the staff of the U.S. Nuclear Regulatory Commission describes (1) background information regarding the licensing and history of independent spent fuel storage installations (ISFSIs), (2) a discussion of the licensing process, (3) a description of all currently approved or certified models of dry cask storage systems (DCSSs), and (4) a description of sites currently storing spent fuel in an ISFSI. Storage of spent fuel at ISFSIs must be in accordance with the provisions of 10 CFR Part 72. The staff has provided this handbook for information purposes only. The accuracy of any information herein is not guaranteed. For verification or for more details, the reader should refer to the respective docket files for each DCSS and ISFSI site. The information in this handbook is current as of September 1, 1996

Physical electronics handbook of vacuum physics

CERN Document Server

Beck, A H

2013-01-01

Handbook of Vacuum Physics, Volume 2, Physical Electronics, discusses the fundamentals of electric discharges in gases. Electrical discharges in gases is used generically to denote the passage of electricity through a gas and implicitly embraces the wide variety of physical phenomena which accompany such a discharge of electricity. The discharge currents may be as small as 10-16A in certain ionization growth studies, or be as large as megamperes in thermonuclear and plasma physics studies. Key topics discussed include collision phenomena in gases; surface phenomena and transport of charged par

Handbook of spin transport and magnetism

CERN Document Server

Tsymbal, Evgeny Y

2011-01-01

In the past several decades, the research on spin transport and magnetism has led to remarkable scientific and technological breakthroughs, including Albert Fert and Peter Grünberg's Nobel Prize-winning discovery of giant magnetoresistance (GMR) in magnetic metallic multilayers. Handbook of Spin Transport and Magnetism provides a comprehensive, balanced account of the state of the art in the field known as spin electronics or spintronics. It reveals how key phenomena first discovered in one class of materials, such as spin injection in metals, have been revisited decades later in other materia

Handbook of digital games and entertainment technologies

CERN Document Server

Rauterberg, Matthias; Ciancarini, Paolo

2017-01-01

The topics treated in this handbook cover all areas of games and entertainment technologies, such as digital entertainment; technology, design/art, and sociology. The handbook consists of contributions from top class scholars and researchers from the interdisciplinary topic areas.  The aim of this handbook is to serving as a key reference work in the field and provides readers with a holistic picture of this interdisciplinary field covering technical issues, aesthetic/design issues, and sociological issues. At present, there is no reference work in the field that provides such a broad and complete picture of the field. Engineers and researchers who want to learn about this emerging area will be able to find adequate answers regarding technology issues on digital entertainment. Designers and artists can learn how their skills and expertise can contribute to this emerging area. Also researchers working in the field of sociology and psychology will find how their experience and knowledge are connected to other ...

Handbook on the history of mathematics education

CERN Document Server

Schubring, Gert

2014-01-01

This is the first comprehensive International Handbook on the History of Mathematics Education, covering a wide spectrum of epochs and civilizations, countries and cultures. Until now, much of the research into the rich and varied history of mathematics education has remained inaccessible to the vast majority of scholars,  not least because it has been written in the language, and for readers, of an individual country. And yet a historical overview, however brief, has become an indispensable element of nearly every dissertation and scholarly article. This handbook provides, for the first time, a comprehensive and systematic aid for researchers around the world in finding the information they need about historical developments in mathematics education, not only in their own countries, but globally as well. Although written primarily for mathematics educators, this handbook will also be of interest to researchers of the history of education in general, as well as specialists in cultural and even social history...

BOOK REVIEW Handbook of Physics in Medicine and Biology Handbook of Physics in Medicine and Biology

Science.gov (United States)

Tabakov, Slavik

2010-11-01

This is a multi-author handbook (66 authors) aiming to describe various applications of physics to medicine and biology, from anatomy and physiology to medical equipment. This unusual reference book has 44 chapters organized in seven sections: 1. Anatomical physics; 2. Physics of perception; 3. Biomechanics; 4. Electrical physics; 5. Diagnostic physics; 6. Physics of accessory medicine; 7. Physics of bioengineering. Each chapter has separate page numbering, which is inconvenient but understandable with the number of authors. Similarly there is some variation in the emphasis of chapters: for some the emphasis is more technical and for others clinical. Each chapter has a separate list of references. The handbook includes hundreds of diagrams, images and tables, making it a useful tool for both medical physicists/engineers and other medical/biology specialists. The first section (about 40 pages) includes five chapters on physics of the cell membrane; protein signaling; cell biology and biophysics of the cell membrane; cellular thermodynamics; action potential transmission and volume conduction. The physics of these is well explained and illustrated with clear diagrams and formulae, so it could be a suitable reference for physicists/engineers. The chapters on cellular thermodynamics and action potential transmission have a very good balance of technical/clinical content. The second section (about 85 pages) includes six chapters on medical decision making; senses; somatic senses: touch and pain; hearing; vision; electroreception. Again these are well illustrated and a suitable reference for physicists/engineers. The chapter on hearing stands out with good balance and treatment of material, but some other chapters contain less physics and are close to typical physiological explanations. One could query the inclusion of the chapter on medical decision making, which also needs more detail. The third section (about 80 pages) includes eight chapters on biomechanics

Capillary Condensation in Confined Media

OpenAIRE

Charlaix, Elisabeth; Ciccotti, Matteo

2009-01-01

28 pages - To appear in 2010 in the Handbook of Nanophysics - Vol 1 - Edited by Klaus Sattler - CRC Press; We review here the physics of capillary condensation of liquids in confined media, with a special regard to the application in nanotechnologies. The thermodynamics of capillary condensation and thin film adsorption are first exposed along with all the relevant notions. The focus is then shifted to the modelling of capillary forces, to their measurements techniques (including SFA, AFM and...

Phase-change materials handbook

Science.gov (United States)

Hale, D. V.; Hoover, M. J.; Oneill, M. J.

1972-01-01

Handbook describes relationship between phase-change materials and more conventional thermal control techniques and discusses materials' space and terrestrial applications. Material properties of most promising phase-change materials and purposes and uses of metallic filler materials in phase-change material composites are provided.

Integrated Baseline Review (IBR) Handbook

Science.gov (United States)

Fleming, Jon F.; Kehrer, Kristen C.

2016-01-01

The purpose of this handbook is intended to be a how-to guide to prepare for, conduct, and close-out an Integrated Baseline Review (IBR). It discusses the steps that should be considered, describes roles and responsibilities, tips for tailoring the IBR based on risk, cost, and need for management insight, and provides lessons learned from past IBRs. Appendices contain example documentation typically used in connection with an IBR. Note that these appendices are examples only, and should be tailored to meet the needs of individual projects and contracts. Following the guidance in this handbook will help customers and suppliers preparing for an IBR understand the expectations of the IBR, and ensure that the IBR meets the requirements for both in-house and contract efforts.