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Sample records for inclination doses range

  1. Inclined head position improves dose distribution during hippocampal-sparing whole brain radiotherapy using VMAT

    International Nuclear Information System (INIS)

    Kim, Kyung Su; Seo, Suk-Jin; Lee, Jaegi; Kim, Eunji; Choi, Noorie; Seok, Jin-Yong; Hong, Joo Wan; Chung, Jin-Beom; Eom, Keun-Yong; Kim, Jae-Sung; Kim, In Ah

    2016-01-01

    Hippocampal-sparing whole brain radiotherapy (HS-WBRT) aims to preserve neurocognitive functions in patients undergoing brain radiotherapy (RT). Volumetric modulated arc therapy (VMAT) involves intensity-modulated RT using a coplanar arc. An inclined head position might improve dose distribution during HS-WBRT using VMAT. This study analyzed 8 patients receiving brain RT with inclined head positioning. A comparable set of CT images simulating a non-inclined head position was obtained by rotating the original CT set. HS-WBRT plans of coplanar VMAT for each CT set were generated with a prescribed dose of 30 Gy in 10 fractions. Maximum dose to the hippocampi was limited to 16 Gy; to the optic nerve, optic chiasm, and eyeballs this was confined to less than 37.5 Gy; for the lenses to 8 Gy. Dosimetric parameters of the two different plans of 8 patients were compared with paired t-test. Mean inclined head angle was 11.09 ± 0.73 . The homogeneity (HI) and conformity (CI) indexes demonstrated improved results, with an average 8.4 ± 10.0 % (p = 0.041) and 5.3 ± 3.9 % (p = 0.005) reduction, respectively, in the inclined vs. non-inclined position. The inclined head position had lower hippocampi D min (10.45 ± 0.36 Gy), D max (13.70 ± 0.25 Gy), and D mean (12.01 ± 0.38 Gy) values vs. the non-inclined head position (D min = 12.07 ± 1.07 Gy; D max = 15.70 ± 1.25 Gy; D mean = 13.91 ± 1.01 Gy), with 12.8 ± 8.9 % (p = 0.007), 12.2 ± 6.8 % (p = 0.003), and 13.2 ± 7.2 % (p = 0.002) reductions, respectively. Mean D max for the lenses was 6.34 ± 0.72 Gy and 7.60 ± 0.46 Gy, respectively, with a 16.3 ± 10.8 % reduction in the inclined position (p = 0.004). D max for the optic nerve and D mean for the eyeballs also decreased by 7.0 ± 5.9 % (p = 0.015) and 8.4 ± 7.2 % (p = 0.015), respectively. Inclining the head position to approximately 11 during HS-WBRT using VMAT improved dose distribution in the planning target volume and allowed lower doses to the hippocampi and

  2. High-temperature absorbed dose measurements in the megagray range

    International Nuclear Information System (INIS)

    Balian, P.; Ardonceau, J.; Zuppiroli, L.

    1988-01-01

    Organic conductors of the tetraselenotetracene family have been tested as ''high-temperature'' absorbed dose dosimeters. They were heated up to 120 0 C and irradiated at this temperature with 1-MeV electrons in order to simulate, in a short time, a much longer γ-ray irradiation. The electric resistance increase of the crystal can be considered a good measurement of the absorbed dose in the range 10 6 Gy to a few 10 8 Gy and presumably one order of magnitude more. This dosimeter also permits on-line (in-situ) measurements of the absorbed dose without removing the sensor from the irradiation site. The respective advantages of organic and inorganic dosimeters at these temperature and dose ranges are also discussed. In this connection, we outline new, but negative, results concerning the possible use of silica as a high-temperature, high-dose dosimeter. (author)

  3. Effective dose range for dental cone beam computed tomography scanners

    International Nuclear Information System (INIS)

    Pauwels, Ruben; Beinsberger, Jilke; Collaert, Bruno; Theodorakou, Chrysoula; Rogers, Jessica; Walker, Anne; Cockmartin, Lesley; Bosmans, Hilde; Jacobs, Reinhilde; Bogaerts, Ria; Horner, Keith

    2012-01-01

    Objective: To estimate the absorbed organ dose and effective dose for a wide range of cone beam computed tomography scanners, using different exposure protocols and geometries. Materials and methods: Two Alderson Radiation Therapy anthropomorphic phantoms were loaded with LiF detectors (TLD-100 and TLD-100H) which were evenly distributed throughout the head and neck, covering all radiosensitive organs. Measurements were performed on 14 CBCT devices: 3D Accuitomo 170, Galileos Comfort, i-CAT Next Generation, Iluma Elite, Kodak 9000 3D, Kodak 9500, NewTom VG, NewTom VGi, Pax-Uni3D, Picasso Trio, ProMax 3D, Scanora 3D, SkyView, Veraviewepocs 3D. Effective dose was calculated using the ICRP 103 (2007) tissue weighting factors. Results: Effective dose ranged between 19 and 368 μSv. The largest contributions to the effective dose were from the remainder tissues (37%), salivary glands (24%), and thyroid gland (21%). For all organs, there was a wide range of measured values apparent, due to differences in exposure factors, diameter and height of the primary beam, and positioning of the beam relative to the radiosensitive organs. Conclusions: The effective dose for different CBCT devices showed a 20-fold range. The results show that a distinction is needed between small-, medium-, and large-field CBCT scanners and protocols, as they are applied to different indication groups, the dose received being strongly related to field size. Furthermore, the dose should always be considered relative to technical and diagnostic image quality, seeing that image quality requirements also differ for patient groups. The results from the current study indicate that the optimisation of dose should be performed by an appropriate selection of exposure parameters and field size, depending on the diagnostic requirements.

  4. Inclined planes

    CERN Document Server

    Rivera, Andrea

    2016-01-01

    From moving ramps to playground slides, inclined planes are at work all over in our world today. Learn all about them in five easy-to-read chapters. Vibrant, full-color photos, bolded glossary words, and a key stats section let readers zoom in even deeper. Aligned to Common Core Standards and correlated to state standards. Abdo Zoom is a division of ABDO.

  5. Sibutramine in weight control: a dose-ranging, efficacy study.

    Science.gov (United States)

    Weintraub, M; Rubio, A; Golik, A; Byrne, L; Scheinbaum, M L

    1991-09-01

    We tested the safety and efficacy of sibutramine, 5 and 20 mg, and placebo on weight loss. Medication was added to caloric restriction, behavior modification, and exercise in a parallel-group, double-blind clinical trial. Participants were 130% to 180% of ideal body weight and in good health. The study lasted 12 weeks over Thanksgiving, Christmas, and New Year's Day. Weight loss during 8 weeks of study medication was: placebo, 1.4 +/- 2.1 kg (n = 19); 5 mg sibutramine, 2.9 +/- 2.3 kg (n = 18); and 20 mg sibutramine, 5.0 +/- 2.7 kg (n = 18) (p less than 0.05 sibutramine, 5 and 20 mg, versus placebo; p less than 0.05 sibutramine, 20 mg versus 5 mg). There is a significant dose-effect relationship. Five participants left the study before completion, all because of adverse events; placebo (one patient), 5 mg sibutramine (one patient), and 20 mg sibutramine (three patients). Sleep difficulties were noted by eight participants (20 mg sibutramine, seven patients; 5 mg, one patient; and placebo, no patients). Six of 21 participants receiving 20 mg complained of irritability, unusual impatience, or "excitation." Sibutramine, 5 and 20 mg, added to a multimodal program assisted participants in losing weight.

  6. Real-life effectiveness of omalizumab in severe allergic asthma above the recommended dosing range criteria.

    Science.gov (United States)

    Hew, M; Gillman, A; Sutherland, M; Wark, P; Bowden, J; Guo, M; Reddel, H K; Jenkins, C; Marks, G B; Thien, F; Rimmer, J; Katsoulotos, G P; Cook, M; Yang, I; Katelaris, C; Bowler, S; Langton, D; Wright, C; Bint, M; Yozghatlian, V; Burgess, S; Sivakumaran, P; Yan, K Y; Kritikos, V; Peters, M; Baraket, M; Aminazad, A; Robinson, P; Jaffe, A; Powell, H; Upham, J W; McDonald, V M; Gibson, P G

    2016-11-01

    Omalizumab (Xolair) dosing in severe allergic asthma is based on serum IgE and bodyweight. In Australia, patients eligible for omalizumab but exceeding recommended ranges for IgE (30-1500 IU/mL) and bodyweight (30-150 kg) may still receive a ceiling dose of 750 mg/4 weeks. About 62% of patients receiving government-subsidized omalizumab are enrolled in the Australian Xolair Registry (AXR). To determine whether AXR participants above the recommended dosing ranges benefit from omalizumab and to compare their response to within-range participants. Data were stratified according to dose range status (above-range or within-range). Further sub-analyses were conducted according to the reason for being above the dosing range (IgE only vs. IgE and weight). Data for 179 participants were analysed. About 55 (31%) were above recommended dosing criteria; other characteristics were similar to within-range participants. Above-range participants had higher baseline IgE [812 (IQR 632, 1747) IU/mL vs. 209 (IQR 134, 306) IU/mL] and received higher doses of omalizumab [750 (IQR 650, 750) mg] compared to within-range participants [450 (IQR, 300, 600) mg]. At 6 months, improvements in Juniper 5-item Asthma Control Questionnaire (ACQ-5, 3.61 down to 2.01 for above-range, 3.47 down to 1.93 for within-range, P omalizumab have significantly improved symptom control, quality of life and lung function to a similar degree to within-range participants, achieved without dose escalation above 750 mg. © 2016 John Wiley & Sons Ltd.

  7. A logistic dose-ranging method for phase I clinical investigations trials.

    Science.gov (United States)

    Murphy, J R; Hall, D L

    1997-11-01

    This paper describes an alternative to the continual reassessment method (CRM) for phase I trials. The logistic dose ranging strategy (LDRS) uses logistic regression and a dose allocation scheme similar to the CRM. It can easily be implemented from any logistic regression program. The LDRS can be a stand alone dose allocation scheme or it can be incorporated into standard three on a dose strategies to indicate when escalation can proceed more rapidly. Finally, the effect of covariates such as age or comorbid conditions on the toxicity expected for the dose selected for a phase II trial can be examined.

  8. Alternative chitosan-based EPR dosimeter applicable for a relatively wide range of gamma radiation doses

    Science.gov (United States)

    Piroonpan, Thananchai; Katemake, Pichayada; Panritdam, Eagkapong; Pasanphan, Wanvimol

    2017-12-01

    Chitosan biopolymer is proposed as an alternative EPR dosimeter. Its ability to be EPR dosimeter was studied in comparison with the conventional alanine, sugars (i.e., glucose and sucrose), formate derivatives (i.e., lithium (Li), magnesium (Mg), and calcium (Ca) formate). Ethylene vinyl acetate (EVA) and paraffin were used as binder for the preparation of composite EPR dosimeter. Dose responses of all materials were investigated in a wide dose range of radiation doses, i.e., low-level (0-1 kGy), medium-level (1-10 kGy) and high-level (10-100 kGy). The EPR dosimeter properties were studied under different parameters, i.e., microwave power, materials contents, absorbed doses, storage conditions and post-irradiation effects. Li-formate showed a simple EPR spectrum and exhibited superior radiation response for low-dose range; whereas chitosan and sucrose exhibited linear dose response in all studied dose ranges. The EPR signals of chitosan exhibited similar stability as glucose, Li-formate and alanine at ambient temperature after irradiation as long as a year. All EPR signals of the studied materials were affected post-irradiation temperature and humidity after gamma irradiation. The EPR signal of chitosan exhibited long-term stability and it was not sensitive to high storage temperatures and humidity values after irradiation. Chitosan has a good merit as the alternative bio-based material for a stable EPR dosimeter in a wide range of radiation-absorbed doses.

  9. Vehicle with inclinable caterpillars

    International Nuclear Information System (INIS)

    Carra, O.; Delevallee, A.

    1991-01-01

    Vehicle has a body with propulsion assemblies that drive caterpillar tracks. When a propulsion unit inclines about its articulation axis it is aided by an advance movement of the caterpillar track in the opposite direction of rotation [fr

  10. Applichation of the sulphate ceric dosimetric in the high doses range

    International Nuclear Information System (INIS)

    Prieto Miranda, F.

    1991-01-01

    The ceric-cerous dosimetric system is one of the system more employed in the high dose dosimetry. The spectrophotometric procedure to measure the ceric-concentration is an usual analityc method to determine the absorbed dose. On the other hand, due at increase employ of the irradiation process control. In this paper is realized the ceric-cerous dosimetric calibration in the dose range of 0,6 - 5 kGy and the application in the irradiation process control to differents absorbed dose values

  11. The influence of patient positioning uncertainties in proton radiotherapy on proton range and dose distributions.

    Science.gov (United States)

    Liebl, Jakob; Paganetti, Harald; Zhu, Mingyao; Winey, Brian A

    2014-09-01

    Proton radiotherapy allows radiation treatment delivery with high dose gradients. The nature of such dose distributions increases the influence of patient positioning uncertainties on their fidelity when compared to photon radiotherapy. The present work quantitatively analyzes the influence of setup uncertainties on proton range and dose distributions. Thirty-eight clinical passive scattering treatment fields for small lesions in the head were studied. Dose distributions for shifted and rotated patient positions were Monte Carlo-simulated. Proton range uncertainties at the 50%- and 90%-dose falloff position were calculated considering 18 arbitrary combinations of maximal patient position shifts and rotations for two patient positioning methods. Normal tissue complication probabilities (NTCPs), equivalent uniform doses (EUDs), and tumor control probabilities (TCPs) were studied for organs at risk (OARs) and target volumes of eight patients. The authors identified a median 1σ proton range uncertainty at the 50%-dose falloff of 2.8 mm for anatomy-based patient positioning and 1.6 mm for fiducial-based patient positioning as well as 7.2 and 5.8 mm for the 90%-dose falloff position, respectively. These range uncertainties were correlated to heterogeneity indices (HIs) calculated for each treatment field (38%positioning) and 1.2% (fiducial-based positioning) of the studied OARs and patient shifts. For target volumes TCP decreases by more than 10% (absolute) occurred in less than 2.2% of the considered treatment scenarios for anatomy-based patient positioning and were nonexistent for fiducial-based patient positioning. EUD changes for target volumes were up to 35% (anatomy-based positioning) and 16% (fiducial-based positioning). The influence of patient positioning uncertainties on proton range in therapy of small lesions in the human brain as well as target and OAR dosimetry were studied. Observed range uncertainties were correlated with HIs. The clinical practice of

  12. The continual reassessment method: comparison of Bayesian stopping rules for dose-ranging studies.

    Science.gov (United States)

    Zohar, S; Chevret, S

    2001-10-15

    The continual reassessment method (CRM) provides a Bayesian estimation of the maximum tolerated dose (MTD) in phase I clinical trials and is also used to estimate the minimal efficacy dose (MED) in phase II clinical trials. In this paper we propose Bayesian stopping rules for the CRM, based on either posterior or predictive probability distributions that can be applied sequentially during the trial. These rules aim at early detection of either the mis-choice of dose range or a prefixed gain in the point estimate or accuracy of estimated probability of response associated with the MTD (or MED). They were compared through a simulation study under six situations that could represent the underlying unknown dose-response (either toxicity or failure) relationship, in terms of sample size, probability of correct selection and bias of the response probability associated to the MTD (or MED). Our results show that the stopping rules act correctly, with early stopping by using the two first rules based on the posterior distribution when the actual underlying dose-response relationship is far from that initially supposed, while the rules based on predictive gain functions provide a discontinuation of inclusions whatever the actual dose-response curve after 20 patients on average, that is, depending mostly on the accumulated data. The stopping rules were then applied to a data set from a dose-ranging phase II clinical trial aiming at estimating the MED dose of midazolam in the sedation of infants during cardiac catheterization. All these findings suggest the early use of the two first rules to detect a mis-choice of dose range, while they confirm the requirement of including at least 20 patients at the same dose to reach an accurate estimate of MTD (MED). A two-stage design is under study. Copyright 2001 John Wiley & Sons, Ltd.

  13. Optimal antiproteinuric dose of losartan in nondiabetic patients with nephrotic range proteinuria.

    Science.gov (United States)

    Laverman, G D; Henning, R H; de Jong, P E; Navis, G; de Zeeuw, D

    2001-12-01

    Although the antiproteinuric response to antihypertensive treatment is the main predictor of renoprotective efficacy in long-term renal disease, to date, dose-finding studies of antihypertensives have been based only on blood pressure. We aimed to find the optimal antiproteinuric dose of the angiotensin II antagonist losartan. An open-label, dose-response study using subsequent 6-week treatment periods was performed in 10 nondiabetic patients with proteinuria of 5.8 +/- 0.8 g/d and a mean arterial pressure of 103 +/- 3.7 mm Hg without antihypertensive medication. All patients had normal to moderately impaired renal function. After the baseline period, five periods followed with a daily losartan dose of 50 mg, 100 mg, 150 mg, and 50 mg and a recovery without losartan. At the end of each period, proteinuria and mean arterial pressure were measured. The consecutive doses of losartan had a similar antihypertensive response (-11.3 +/- 2.8% by the 100-mg dose). The optimal antiproteinuric response was reached at 100 mg of losartan (-30 +/- 8%). The 50-mg dose (-13 +/- 7%) was less effective, and the 150-mg dose (-28 +/- 8%) was not more effective. A 100-mg dose of losartan is optimal for reduction of proteinuria in nondiabetic patients with nephrotic range proteinuria.

  14. A wide range survey meter for estimating γ- and β-dose rates

    International Nuclear Information System (INIS)

    Jones, A.R.

    1980-09-01

    A survey meter has been developed to measure β-dose rates in the range 0.1 - 100 rad/h (1 mGy/h - 1 Gy/h) and γ-dose rates in the range 1 mrad/h - 100 rad/h (10 μGy/h-1 Gy/h). It also provides an audible warning of high γ-dose rates and an audible and visible warning when a predetermined γ-dose is exceeded. The report describes the design of the survey meter and presents data measured on the performance of an engineering prototype. Factors which affect performance and have been investigated are temperature, battery voltage (and type of battery), GM counter counting loss, direction of incident radiation, and energy of γ-rays. Finally, the application and calibration of the survey meter are discussed. (auth)

  15. Rescue dose orders as an alternative to range orders: an evidence-based practice project.

    Science.gov (United States)

    Yi, Cassia

    2015-06-01

    Relief of pain is a fundamental aspect of optimal patient care. However, pain management in the inpatient setting is often constrained by concerns related to regulatory oversight, particularly with regard to the use of opioid dose range orders. These concerns can inadvertently result in the development of policies and practices that can negatively impact the health care team's ability to deliver optimal and individualized pain management. An evidence-based practice project was undertaken to address concerns about regulatory oversight of pain management processes by changing the way pain was managed in a large academic hospital setting. A novel pain management approach using rescue dose medications was established as an alternative to opioid dose range orders. The use of the rescue dose protocol was successfully implemented. Outcomes included an overall reduction in the administration of inappropriate intravenous opioids and opioid-acetaminophen combination medications, with a subsequent increase in single-entity first-line opioid analgesics. Rescue dose protocols may offer an alternative to opioid dose range orders as a means of effectively managing pain. Copyright © 2015 American Society of PeriAnesthesia Nurses. Published by Elsevier Inc. All rights reserved.

  16. Dosimetric evaluation of sucrose and granulated cane sugar in the therapeutic dose range.

    Science.gov (United States)

    Davidson, Melanie T M; Jordan, Kevin J

    2009-04-01

    Granulated cane sugar has been used as a dosimetric material to report dose in high dose accidental irradiations. The purpose of this study was to assess whether clinical dosimetry is also plausible with such a commonly available material. The behavior of cane sugar was explored with respect to therapeutically relevant radiation quantities (dose, dose rate) and qualities (energy, radiation type) as well as under different temperature conditions. The stability of the signal postirradiation was also measured. Absorbed dose was measured by spectrophotometric readout of a ferrous ammonium sulfate xylenol orange (FX)-sugar solution in 10 cm path length cells. A visible color change was produced as a function of dose when the irradiated sugar samples were dissolved in FX solution (10% dilution by mass). A comparison of the optical absorbance spectra and dose response of cane sugar with analytical grade sucrose was done to establish a benchmark standard from which subsequent dosimetry measurements can be validated. The response of the sugar dosimeter read at 590 nm was found to be linear over the dose range of 100-2000 cGy, independent of energy (6-18 MV) and of the average dose rate (100-500 cGy/min). The readout of sugar samples irradiated with mixed photon and electron fields was also shown to be independent of radiation type (photons and electrons). Sugar temperature (20-40 degrees C) during irradiation did not affect dose estimates, making it a promising dosimeter for in vivo dosimetry, particularly in cases where the dosimeter must remain in contact with the patient for an extended period of time. Sugar can be used as an integrating dosimeter, since it exhibits no fractionation effects. Granulated cane sugar is cost effective, safe, soft tissue equivalent, and can be used under various experimental conditions, making it a suitable dosimeter for some radiotherapy applications.

  17. An analysis of ingestion doses from a range of postulated Magnox reactor releases

    International Nuclear Information System (INIS)

    Nair, S.

    1985-06-01

    An analysis has been carried out of ingestion doses from a range of postulated Magnox reactor releases to atmosphere. Calculations were made of the dose to the adult, ten year old child and one year old child, which showed the one year old child to receive the highest dose. Detailed studies were made of the significance of the ingestion dose to the one year old child in relation to other exposure routes. The ingestion dose was also analysed in terms of the contributing critical organs, foods and nuclides. Approximate calculations were also made of the dependence of the ingestion dose on the time of year when the release occurs. The results of the analysis were used to derive a set of release-specific Emergency Action Guidance Levels (EAGLs) of critical nuclide concentrations in the critical foods, which comply with NRPB's ingestion ERL recommendations. The EAGLs were supplemented with a corresponding set of EAGLs for grass, for use in situations where crop samples were not readily available. (author)

  18. New Morphine Analogs Produce Peripheral Antinociception within a Certain Dose Range of Their Systemic Administration.

    Science.gov (United States)

    Lackó, Erzsébet; Riba, Pál; Giricz, Zoltán; Váradi, András; Cornic, Laura; Balogh, Mihály; Király, Kornél; Csekő, Kata; Mousa, Shaaban A; Hosztafi, Sándor; Schäfer, Michael; Zádori, Zoltán Sándor; Helyes, Zsuzsanna; Ferdinandy, Péter; Fürst, Susanna; Al-Khrasani, Mahmoud

    2016-10-01

    Growing data support peripheral opioid antinociceptive effects, particularly in inflammatory pain models. Here, we examined the antinociceptive effects of subcutaneously administered, recently synthesized 14-O-methylmorphine-6-O-sulfate (14-O-MeM6SU) compared with morphine-6-O-sulfate (M6SU) in a rat model of inflammatory pain induced by an injection of complete Freund's adjuvant and in a mouse model of visceral pain evoked by acetic acid. Subcutaneous doses of 14-O-MeM6SU and M6SU up to 126 and 547 nmol/kg, respectively, produced significant and subcutaneous or intraplantar naloxone methiodide (NAL-M)-reversible antinociception in inflamed paws compared with noninflamed paws. Neither of these doses significantly affected thiobutabarbital-induced sleeping time or rat pulmonary parameters. However, the antinociceptive effects of higher doses were only partially reversed by NAL-M, indicating contribution of the central nervous system. In the mouse writhing test, 14-O-MeM6SU was more potent than M6SU after subcutaneous or intracerebroventricular injections. Both displayed high subcutaneous/intracerebroventricular ED50 ratios. The antinociceptive effects of subcutaneous 14-O-MeM6SU and M6SU up to 136 and 3043 nmol/kg, respectively, were fully antagonized by subcutaneous NAL-M. In addition, the test compounds inhibited mouse gastrointestinal transit in antinociceptive doses. Taken together, these findings suggest that systemic administration of the novel compound 14-O-MeM6SU similar to M6SU in specific dose ranges shows peripheral antinociception in rat and mouse inflammatory pain models without central adverse effects. These findings apply to male animals and must be confirmed in female animals. Therefore, titration of systemic doses of opioid compounds with limited access to the brain might offer peripheral antinociception of clinical importance. Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics.

  19. Radiation-induced polymerization of water-saturated styrene in a wide range of dose rate

    International Nuclear Information System (INIS)

    Takezaki, J.; Okada, T.; Sakurada, I.

    1978-01-01

    Radiation-induced polymerization of water-saturated styrene (water content 3.5 x 10 -2 mole/liter) was carried out in a wide range of dose rate between 1.2 x 10 3 and 1.8 x 10 7 rad/sec, and compared with the polymerization of the moderately dried styrene (water content 3.2 x 10 -3 mole/liter). Molecular weight distribution curves of the polymerization products showed that they were generally consisted of four parts, namely, oligomers, radical, cationic, and super polymers. Contributions of the four constituents to the polymerization and the number average degrees of polymerization (DP) of the four kinds of polymers were calculated by the graphical analysis of the curves. The rate of radical polymerization and DP of radical polymers are independent of the water content; the dose rate dependences of the polymerization rate and DP agree with the well known square root and inverse square root laws, respectively, of the radical polymerization of styrene. The rate of ionic polymerization is directly proportional to the dose rate, but it decreases, at a given dose rate, inversely proportional to the water content of styrene. DP of ionic polymer is independent of the dose rate but decreases with increasing water content. The super polymer of DP about 10 4 is not formed in the case of the moderately dried styrene. G values for the initiating radical and ion formation are calculated to be independently of the dose rate and water content, 0.66 and 0.027, respectively. It was suggested that oligomer was formed in the early stage by the interaction of cation with anion and only those cations which had survived underwent polymerization. 10 figures, 4 tables

  20. Evaporation of inclined water droplets

    Science.gov (United States)

    Kim, Jin Young; Hwang, In Gyu; Weon, Byung Mook

    2017-01-01

    When a drop is placed on a flat substrate tilted at an inclined angle, it can be deformed by gravity and its initial contact angle divides into front and rear contact angles by inclination. Here we study on evaporation dynamics of a pure water droplet on a flat solid substrate by controlling substrate inclination and measuring mass and volume changes of an evaporating droplet with time. We find that complete evaporation time of an inclined droplet becomes longer as gravitational influence by inclination becomes stronger. The gravity itself does not change the evaporation dynamics directly, whereas the gravity-induced droplet deformation increases the difference between front and rear angles, which quickens the onset of depinning and consequently reduces the contact radius. This result makes the evaporation rate of an inclined droplet to be slow. This finding would be important to improve understanding on evaporation dynamics of inclined droplets. PMID:28205642

  1. Bidispersive-inclined convection

    Science.gov (United States)

    Mulone, Giuseppe; Straughan, Brian

    2016-01-01

    A model is presented for thermal convection in an inclined layer of porous material when the medium has a bidispersive structure. Thus, there are the usual macropores which are full of a fluid, but there are also a system of micropores full of the same fluid. The model we employ is a modification of the one proposed by Nield & Kuznetsov (2006 Int. J. Heat Mass Transf. 49, 3068–3074. (doi:10.1016/j.ijheatmasstransfer.2006.02.008)), although we consider a single temperature field only. PMID:27616934

  2. Simulating threshold voltage shift of MOS devices due to radiation in the low-dose range

    CERN Document Server

    Wan Xin Heng; Gao Wen Yu; Huang Ru; Wang Yang Yuan

    2002-01-01

    An analytical MOSFET threshold voltage shift model due to radiation in the low-dose range has been developed for circuit simulations. Experimental data in the literature shows that the model predictions are in good agreement. It is simple in functional form and hence computationally efficient. It can be used as a basic circuit simulation tool for analysing MOSFET exposed to a nuclear environment up to about 1 Mrad(Si). In accordance with common believe, radiation induced absolute change of threshold voltage was found to be larger in irradiated PMOS devices. However, if the radiation sensitivity is defined in the way authors did it, the results indicated NMOS rather than PMOS devices are more sensitive, specially at low doses. This is important from the standpoint of their possible application in dosimetry

  3. Radiolysis of aqueous solutions of ammonium bicarbonate over a large dose range

    International Nuclear Information System (INIS)

    Draganic, Z.D.; Negron-Mendoza, A.; Vujosevic, S.I.; Navarro-Gonzales, R.; Albarran-Sanchez, M.G.

    1991-01-01

    Oxygen-free aqueous solutions of 0.05 mol dm -3 ammonium and sodium bicarbonate were studied after receiving various doses of 60 Co gammas (0.01-400 kGy) or 0.5-20 Gy pulses of 10 Mev electrons. Formate and oxalate were found to be the main radiolytic products, in addition to trace amounts of formaldehyde and an unidentified polymer. A large initial yield of formate in the γ-radiolysis, G(HCOO - ) = 2.2, is due to the reaction COO - + HCO 3 - ↔ HCOO - +CO 3 - . The efficiency of organic synthesis within the large dose range studied is low and is explained by efficient pathways leading to the reformation of bicarbonate, where the reaction COO - + CO 3 - is particularly significant. (author)

  4. Fundamental investigations of natural and laboratory generated SAR dose response curves for quartz OSL in the high dose range

    DEFF Research Database (Denmark)

    Timar-Gabor, Alida; Constantin, Daniela; Buylaert, Jan-Pieter

    2015-01-01

    SAR-OSL investigations on quartz from Romanian loess resulted in non concordant fine and coarse-grain ages for equivalent doses higher than ~100 Gy. The laboratory dose response for both grain sizes is well represented by a sum of two saturating exponential functions, fine and coarse grains chara...... equivalent dose of 2000e2500 Gy were found to be below the saturation level of the laboratory dose response curve for both grain sizes; this also applied to the luminescence signals measured after >5000 Gy given on top of natural doses. © 2015 Elsevier Ltd. All rights reserved....

  5. Efficacy and tolerability of orlistat in the treatment of obesity: a 6-month dose-ranging study. Orlistat Dose-Ranging Study Group.

    Science.gov (United States)

    Van Gaal, L F; Broom, J I; Enzi, G; Toplak, H

    1998-04-01

    To determine the weight-reducing efficacy of orlistat, a novel gastrointestinal lipase inhibitor, and to define the optimal dosage regimen and establish the tolerability of the drug when used for a 6-month treatment period. The study was a multicentre randomised, double-blind, parallel group in design and involved 676 obese male and female subjects aged at least 18 years with a body mass index between 28 and 43 kg x m(-2) Following a 5-week placebo run-in period, subjects were randomised to receive orlistat 30 mg, 60 mg, 120 mg, 240 mg or matching placebo three times a day (tid) for 24 weeks during meals. Patients were maintained on a mildly hypocaloric diet throughout the study period. The primary efficacy parameter was body weight change over time. Orlistat resulted in a significantly greater mean loss of body weight than observed in the placebo group. In absolute terms, mean weight loss was greatest in the 120 mg group (9.8%). More orlistat- than placebo-treated patients lost > 10% of initial body weight (37% of the 120 mg group vs 19% of the placebo group). Orlistat was well tolerated. Predictably, in view of its known pharmacological effects, more orlistat-treated patients experienced gastrointestinal events. Mean levels of vitamins A, D and E, and beta-carotene remained within the clinical reference ranges in all treatment groups and rarely required supplementation. After 24 weeks, plasma concentrations of orlistat were either non-measurable or detected at the assay's limit of quantitation. Orlistat treatment results in a dose-dependent reduction in body weight in obese subjects and is well tolerated. Orlistat 120 mg tid represents the optimal dosage regimen.

  6. Radiation doses due to long-range transport of airborne radionuclides

    International Nuclear Information System (INIS)

    Nordlund, G.; Valkama, I.; Rossi, J.; Savolainen, I.

    1985-12-01

    Within the framework of this study a model for estimating the long range transport of radioactive material and for calculating the resultant doses is developed. In the model initially the dispersion paths, i.e. trajectories, of the radioactive matter are calculated from the assumed source areas as well as the dispersion conditions along the trajectories. The trajectories are calculated at three-hour intervals in a two-dimensional grid using numerically analysed winds at a constant pressure level of 850 mb. The dispersion condition parameters applied are: the stability of the atmospheric boundary layer, the so-called mixing height, occurrence of precipitation and the character of the terrain. For each trajectory a type-index value is computed, describing the severity of the possible effects of radioactivity transported by the particular trajectory. The dispersion model uses the information on dispersion conditions provided by the trajectory model to compute the remaining radioactivity in the cloud, the deposition, as well as the doses due to different dose pathways. The pathways used are the external radiation from the cloud and from the activity deposited on the ground, inhalation of radioactive material and ingestion of contaminated food products (milk, meat, green vegetables, grain and roots). In addition to the effects of individual transport incidents, the cumulative probability distributions of the effects of accidental releases of radioactive matter can also be calculated using trajectory statistics and the trajectory type index

  7. /sup 210/Po in marine organisms: a wide range of natural radiation dose domains

    Energy Technology Data Exchange (ETDEWEB)

    Carvalho, F.P.

    1988-01-01

    Marine biota is able to concentrate /sup 210/Po to high levels, as 10/sup 3/-10/sup 5/ relative to sea water concentration. /sup 210/Po concentrations in mixed zooplankton reaches 34-51 Bq.kg/sup -1/ (fresh wt), special groups such as copepods reaching even higher concentrations /similar to/ 90 Bq.kg/sup -1/, whereas gelatinous zooplankton display /similar to/ 1 Bq.kg/sup -1/. Epipelagic teleosts feeding on plankton displayed the highest concentrations found in fish muscle, 2-21 Bq.kg/sup -1/. Contrasting with this, demersal teleosts and elasmobranchs display lower /sup 210/Po concentrations, in the ranges 0.5-7 Bq.kg/sup -1/ and 0.2-1.7 Bq.kg/sup -1/, respectively. Much higher concentrations can, however, be measured in fish liver, gonad, bone and piloric caecca, and small mesopelagic fish can reach /similar to/ 800 Bq.kg/sup -1/ on a whole-body basis. Due to these /sup 210/Po activity concentrations, dose equivalent rates delivered to biological tissues in marine organisms can vary widely, from 0.4 mSv.y/sup -1/ in gelatinous plankton up to 5.6 x 10/sup 3/ mSv.y/sup -1/ in the gut wall of sardines. It is concluded that in organisms living in the same ocean layer a wide range of internal radiation doses exists and it is essentially sustained by /sup 210/Po food-chain transfer. (author).

  8. Psychosocial Determinants of Romantic Inclination Among Indian Youth

    Directory of Open Access Journals (Sweden)

    D. Barani Ganth

    2017-10-01

    Full Text Available The present study was conducted with the aim of understanding the psychosocial determinants of romantic inclination among youth in India. We involved 779 student participants from a large central university in south India in the age range of 18-24 years. The participants filled measures on romantic inclination, personality, attachment style, interpersonal attraction, and social influence on romantic relationship in addition to a questionnaire on demographic information and relationship history. Analysis of the data revealed that males showed higher level of romantic inclination than females. Those who had current/past involvement in a romantic relationship (Lovers showed higher levels of romantic inclination than those who had never involved in a romantic relationship (Non-lovers. Parents’ type of marriage (Love/arranged, close fiends’ involvement in romantic relationship too had a discriminatory role in romantic inclination. Romantic inclination was significantly related to personality factors, attachment style, media and peer influences on romantic relationships and interpersonal attraction. Extraversion, openness to experience, agreeableness, media influence, peer influence, secure attachment and physical attraction emerged as significant predictors of romantic inclination in a regression model. Structural Equations Modeling (SEM indicated that personality, attachment style and interpersonal attraction had a significant influence on romantic inclination mediated by both media and peer influences. Romantic inclination in turn significantly predicted romantic relationship status.

  9. Homeostatic balance as an indicator of prolonged technogenic exposure in low dose range

    International Nuclear Information System (INIS)

    Karpov, A.B.; Voronova, I.A.; Takhauov, R.M.; Semyonova, Yu.V.; Sherstoboev, E.Yu.; Udut, V.V.

    2008-01-01

    Full text: Indication of changes induced by ionizing radiation starting up a wide range of pathologic reactions in the disease developments still poses a significant problem in radiation medicine. It mainly concerns exposure to low dose-rate ionizing radiation, since its effects are still open to question, and today any researcher acknowledges that radiation induced pathological changes can accumulate at both subclinical and prenosological stages and develop not only in exposed persons, but also in their offspring. The subject of this study was workers of reactor and radiochemical productions of Siberian Group of Chemical Enterprises (SGCE) exposed to external and combined (external and internal) radiation respectively. Two comparative groups were formed: reactor and radiochemical production workers. In the reactor production group of workers the cumulative dose of external γ-radiation was up to 300 mSv, in the radiochemical production group - up to 150 mSv. Age ranged from 40 to 50 years. The two groups were compared between each other. Above all, there were formed 'insider control' groups (workers of the same productions with zero doses) to assess the impact of radiation factor on central homeostatic mechanisms. These groups were created using pair technique in order to level somatic disorders influence on the parameters under study. Numbers of full and biochemical blood examinations, energy metabolism between cells, hormones of homeostasis by the adaptive hormone level - insulin and cortisol, lipid peroxidation and antioxidant protection systems, immune and vegetative systems were all analyzed. Analyses of the systems performed, it was found out that in persons having been exposed to long term occupational radiation there were significant changes indicating lipid peroxidation system activation, antioxidant protection system depression, as well as lowered energy metabolism. The higher external γ-doses the bigger these changes are. Results from the two groups of

  10. Radiolysis of aqueous solutions of ammonium bicarbonate over a large dose range

    International Nuclear Information System (INIS)

    Draganic, Z.D.; Draganic, I.G.; Negron-Mendoza, A.; Navarro-Gonzales, R.; Albarran-Sanchez, M.G.; Sehested, K.

    1986-12-01

    0 2 -free aqueous solutions of 0.05 mol dm -3 ammonium bicarbonate were studied after receiving various doses of 60 Co gammas (0.001-170 Mrd) or krd pulses of 10 MeV electrons. Formate, oxalate, formaldehyde and an unidentified polymer (M w 14000-16000 daltons) were found to be the main radiolytic products. A large initial yield of formate in the γ-radiolysis, G(HCOO - ) = 2.2, is due to the reaction CO 2 - + HCO 3 - ↔ HC00 - + CO 3 - . The efficiency of organic synthesis within the large dose range studied is low and is explained by efficient pathways to the reformation of bicarbonate, where the reaction CO 2 - + CO 3 - is particurlarly significant. Computer fitting of the data obtained in the γ-radiolysis and by pulsed electron beam experiments gives k(CO 2 - + HCO 3 - ) = (2 ± 0.4)x10 3 dm 3 mol -1 s -1 , k(CO 2 - + CO 3 - ) = (5 ± 1)x10 7 dm 3 mol -1 s -1 , k(NH 2 + = HCO 3 - ) 4 dm 3 mol -1 s -1 and k(NH 2 + CO 3 - ) = (1.5 ± 0.5)x10 9 dm 3 mol -1 s -1 . (author)

  11. Radiolysis of aqueous solutions of ammonium bicarbonate over a large dose range

    DEFF Research Database (Denmark)

    Draganic, Z.D.; Negrón-Mendoza, A.; Sehested, K.

    1991-01-01

    Oxygen-free aqueous solutions of 0.05 mol dm-3 ammonium and sodium bicarbonate were studied after receiving various doses of Co-60 gammas (0.01-400 kGy) or 0.5-20 Gy pulses of 10 Mev electrons. Formate and oxalate were found to be the main radiolytic products, in addition to trace amounts...... of formaldehyde and an unidentified polymer. A large initial yield of formate in the gamma-radiolysis, G(HCOO-) = 2.2, is due to the reaction COO- + HCO3- reversible HCOO- + CO3-. The efficiency of organic synthesis within the large dose range studied is low and is explained by efficient pathways leading...... to the reformation of bicarbonate, where the reaction COO- + CO3- is particularly significant. Computer fitting of the data obtained gives k(COO- + HCO3-) = (2 +/- 0.4) x 10(3) dm3 mol-1 s-1, k(COO- + CO3-) = (5 +/- 1) x 10(7) dm3 mol-1 s-1, k(NH2 + HCO3-)

  12. Radiation dose response estimation with emphasis on low dose range using restricted cubic splines: application to all solid cancer mortality data, 1950-2003, in atomic bomb survivors.

    Science.gov (United States)

    Nakashima, Eiji

    2015-07-01

    Using the all solid cancer mortality data set of the Life Span Study (LSS) cohort from 1950 to 2003 (LSS Report 14) data among atomic bomb survivors, excess relative risk (ERR) statistical analyses were performed using the second degree polynomial and the threshold and restricted cubic spline (RCS) dose response models. For the RCS models with 3 to 7 knots of equally spaced percentiles with margins in the dose range greater than 50 mGy, the dose response was assumed to be linear at less than 70 to 90 mGy. Due to the skewed dose distribution of atomic bomb survivors, the current knot system for the RCS analysis results in a detailed depiction of the dose response as less than approximately 0.5 Gy. The 6 knot RCS models for the all-solid cancer mortality dose response of the whole dose or less than 2 Gy were selected with the AIC model selection criterion and fit significantly better (p cubic spline in the lower and upper tails, and the best RCS model selected with AIC criterion was the usual RCS with L-constraints in both the lower and upper tails. The selected RCS had a linear dose-response model in the lower dose range (i.e., < 0.2-0.3 Gy) and was compatible with the linear no-threshold (LNT) model in this dose range. The proposed method is also useful in describing the dose response of a specific cancer or non-cancer disease incidence/mortality.

  13. Reconstruction of paediatric organ doses from axial CT scans performed in the 1990s - range of doses as input to uncertainty estimates.

    Science.gov (United States)

    Olerud, Hilde M; Toft, Benthe; Flatabø, Silje; Jahnen, Andreas; Lee, Choonsik; Thierry-Chef, Isabelle

    2016-09-01

    To assess the range of doses in paediatric CT scans conducted in the 1990s in Norway as input to an international epidemiology study: the EPI-CT study, http://epi-ct.iarc.fr/ . National Cancer Institute dosimetry system for Computed Tomography (NCICT) program based on pre-calculated organ dose conversion coefficients was used to convert CT Dose Index to organ doses in paediatric CT in the 1990s. Protocols reported from local hospitals in a previous Norwegian CT survey were used as input, presuming these were used without optimization for paediatric patients. Large variations in doses between different scanner models and local scan parameter settings are demonstrated. Small children will receive a factor of 2-3 times higher doses compared with adults if the protocols are not optimized for them. For common CT examinations, the doses to the active bone marrow, breast tissue and brain may have exceeded 30 mGy, 60 mGy and 100 mGy respectively, for the youngest children in the 1990s. The doses children received from non-optimised CT examinations during the 1990s are of such magnitude that they may provide statistically significant effects in the EPI-CT study, but probably do not reflect current practice. • Some organ doses from paediatric CT in the 1990s may have exceeded 100 mGy. • Small children may have received doses 2-3 times higher compared with adults. • Different scanner models varied by a factor of 2-3 in dose to patients. • Different local scan parameter settings gave dose variations of a factor 2-3. • Modern CTs and age-adjusted protocols will give much lower paediatric doses.

  14. Simulation of Canopy Leaf Inclination Angle in Rice

    Directory of Open Access Journals (Sweden)

    Xiao-cui ZHANG

    2013-11-01

    Full Text Available A leaf inclination angle distribution model, which is applicable to simulate leaf inclination angle distribution in six heights of layered canopy at different growth stages, was established by component factors affecting plant type in rice. The accuracy of the simulation results was validated by measured values from a field experiment. The coefficient of determination (R2 and the root mean square error (RMSE between the simulated and measured values were 0.9472 and 3.93%, respectively. The simulation results showed that the distribution of leaf inclination angles differed among the three plant types. The leaf inclination angles were larger in the compact variety Liangyoupeijiu with erect leaves than in the loose variety Shanyou 63 with droopy leaves and the intermediate variety Liangyou Y06. The leaf inclination angles were distributed in the lower range in Shanyou 63, which matched up with field measurements. The distribution of leaf inclination angles in the same variety changed throughout the seven growth stages. The leaf inclination angles enlarged gradually from transplanting to booting. During the post-booting period, the leaf inclination angle increased in Shanyou 63 and Liangyou Y06, but changed little in Liangyoupeijiu. At every growth stage of each variety, canopy leaf inclination angle distribution on the six heights of canopy layers was variable. As canopy height increased, the layered leaf area index (LAI decreased in all the three plant types. However, while the leaf inclination angles showed little change in Liangyoupeijiu, they became larger in Shanyou 63 but smaller in Liangyou Y06. The simulation results used in the constructed model were very similar to the actual measurement values. The model provides a method for estimating canopy leaf inclination angle distribution in rice production.

  15. Vocal Range in the Speech of Users of Low-Dose Oral Contraceptives.

    Science.gov (United States)

    Meurer, Eliséa Maria; Moura, Andressa Dias; Rechenberg, Leila; von Eye Corleta, Helena; Capp, Edison

    2017-05-01

    The study aimed to investigate the vocal range of oral contraceptive (OC) users aged between 20 and 30 years. This is a cross-sectional study. Forty-eight women aged 20-30 years who used low-dose OCs and 24 age-matched women who did not use oral monophasic contraceptives (w/oOC) were enrolled. Acoustic analysis was performed using the Motor Speech Profile program, Model 4341 (Kay Elemetrics Corp). Data were analyzed using generalized estimating equation. In the w/oOC group, the highest vocal tones in the sentence uttered using exclamatory intonation were similar in the follicular phases of two cycles (F1: 289 ± 46 Hz; F2: 284 ± 61 Hz). In the luteal phase of the first cycle, the vocal tones were lower, whereas in the second cycle they were higher than the tones in both follicular phases (L1: 274 ± 42 Hz; L2: 291 ± 62 Hz) (P = 0.056). In the highest vocal tones of the same sentence uttered using exclamatory intonation, the OC group showed lower tones (284 ± 53 Hz) than the w/oOC group (298 ± 44 Hz) (P = 0.048). In the lowest vocal tones of utterances of joy, the OC group showed higher values (180 ± 39 Hz) than the w/oOC group (169 ± 44 Hz) (P = 0.024). The close proximity of the highest to the lowest values of utterances of joy in the OC group (321 ± 59 Hz and 180 ± 39 Hz), when related to the w/oOC group (338 ± 65 Hz and 169 ± 44 Hz), suggests a reduced vocal modulation. The present findings demonstrate that the use of low-dose OCs influences the vocal range of women during menacme. Copyright © 2017 The Voice Foundation. Published by Elsevier Inc. All rights reserved.

  16. Optimal antiproteinuric dose of losartan in nondiabetic patients with nephrotic range proteinuria

    NARCIS (Netherlands)

    Laverman, GD; Henning, RH; de Jong, PE; Navis, G; de Zeeuw, D

    2001-01-01

    Although the antiproteinuric response to antihypertensive treatment is the main predictor of renoprotective efficacy in long-term renal disease, to date, dose-finding studies of anti hypertensives have been based only on blood pressure. We aimed to find the optimal antiproteinuric dose of the

  17. Pharmacokinetics and dose requirements of factor VIII over the age range 3-74 years

    DEFF Research Database (Denmark)

    Björkman, Sven; Folkesson, Anna; Jönsson, Siv

    2009-01-01

    in the sparse clinical data. Model-predicted doses (based on age and body weight) to maintain a recommended 0.01 U/mL trough level of FVIII with administration on alternate days started at around 60 U/kg in the small children, decreasing to 10 U/kg or less in middle age. However, "true" dose requirements......, as estimated from individual PK parameter data, showed a much greater variation. CONCLUSION: Appropriate dosing of FVIII for prophylactic treatment cannot be calculated only from body weight and/or age. However, plausible starting doses for most patients would be 1,000 U every other day. FVIII levels should...... can be calculated according to patient characteristics, and (3) to present dosing recommendations for initiating prophylactic treatment. METHODS: A population PK model was developed using data from four PK studies on patients aged 7-74 years. The model was tested on sparse FVIII data from 42...

  18. A thermoluminescence study of mineral silicates extracted from herbs in the dose range 0.5–5 Gy

    International Nuclear Information System (INIS)

    Della Monaca, Sara; Fattibene, Paola; Bortolin, Emanuela

    2013-01-01

    The presence of silicates in many personal objects suggests their potential use at low dose as fortuitous dosimeter in an accidental radiological exposure, when conventional dosimetry is not available. The goal of the present work is the dosimetric characterization of mineral silicates extracted from the plant Hibiscus Sabdariffa L, known as Jamaica flower, in the dose range 0.5–5 Gy. By studying the radiation-induced signal in time, the temperature integration region between 210 °C and 250 °C was found to be the most stable and also reduced the effects of thermal fading in the dose reconstruction process; the dose response curve was linear between 0.5 Gy and 5 Gy. By checking the change in sensitivity after repeated exposures to ionizing radiations and to high temperature heating, no variation in the glow curve shape or peak intensities were detected. To eliminate a pre-existing background signal, all the characterization measurements were performed with aliquots “annealed” by a preliminary readout of the TL. - Highlights: • Glow curves change in shape and intensity just in the first 3 days after irradiation. • The dose response is linear in the dose range 0.5–5 Gy. • The curve shape or intensity don't change after repeated exposures and heatings. • Encouraging results were obtained in the dose recovery test

  19. [Randomized Comparison of Two Approaches to Initial Warfarin Dosing: Time in Therapeutic Range of International Normalized Ratio During Hospitalization].

    Science.gov (United States)

    Gordeev, I G; Averkov, O V; Mishchenko, L N; Levchuk, N N; Vechorko, V I

    2017-09-01

    To perform a randomized, open-label comparison of average time in therapeutic range (TTR) of international normalized ratio (INR) using two approaches to initial warfarin dosing during hospitalization: the standard method and the one using individual patient characteristics (clinical algorithm - the studied approach). We randomly assigned 60 patients with different indications for vitamin K antagonist therapy to the studied approach (n=31, intervention group) or to the standard method (n=29, control group). А target INR range for all patients was 2.0 to 3.0. The average TTR and portions of INR values within target range during the whole time of drug dosing turned out to be small. TTR was 22.4% with standard method and 21.4% with clinical algorithm, which was well below desired 60%. The opportunities for achieving target INR in inpatient settings, regardless of warfarin dosing regimen, are limited.

  20. Dose rate range extension of the calibration of dosemeters at LNMRI, Rio de Janeiro, Brazil

    International Nuclear Information System (INIS)

    Cabral, T.S.; Carlos, M.T.; Ramos, M.M.O.

    2009-01-01

    The present work has an objective the implantation of a experimental arrange for application of essays of instrument calibration for measurement of low dose rate, which measure rate less than 10 μSv/h

  1. Psychosocial Determinants of Romantic Inclination Among Indian Youth

    OpenAIRE

    D. Barani Ganth; S. Kadhiravan

    2017-01-01

    The present study was conducted with the aim of understanding the psychosocial determinants of romantic inclination among youth in India. We involved 779 student participants from a large central university in south India in the age range of 18-24 years. The participants filled measures on romantic inclination, personality, attachment style, interpersonal attraction, and social influence on romantic relationship in addition to a questionnaire on demographic information and relationship histor...

  2. Dose ranging, expanded acute toxicity and safety pharmacology studies for intravenously administered functionalized graphene nanoparticle formulations.

    Science.gov (United States)

    Kanakia, Shruti; Toussaint, Jimmy D; Mullick Chowdhury, Sayan; Tembulkar, Tanuf; Lee, Stephen; Jiang, Ya-Ping; Lin, Richard Z; Shroyer, Kenneth R; Moore, William; Sitharaman, Balaji

    2014-08-01

    Graphene nanoparticle dispersions show immense potential as multifunctional agents for in vivo biomedical applications. Herein, we follow regulatory guidelines for pharmaceuticals that recommend safety pharmacology assessment at least 10-100 times higher than the projected therapeutic dose, and present comprehensive single dose response, expanded acute toxicology, toxicokinetics, and respiratory/cardiovascular safety pharmacology results for intravenously administered dextran-coated graphene oxide nanoplatelet (GNP-Dex) formulations to rats at doses between 1 and 500 mg/kg. Our results indicate that the maximum tolerable dose (MTD) of GNP-Dex is between 50 mg/kg ≤ MTD < 125 mg/kg, blood half-life < 30 min, and majority of nanoparticles excreted within 24 h through feces. Histopathology changes were noted at ≥250 mg/kg in the heart, liver, lung, spleen, and kidney; we found no changes in the brain and no GNP-Dex related effects in the cardiovascular parameters or hematological factors (blood, lipid, and metabolic panels) at doses < 125 mg/kg. The results open avenues for pivotal preclinical single and repeat dose safety studies following good laboratory practices (GLP) as required by regulatory agencies for investigational new drug (IND) application. Copyright © 2014 Elsevier Ltd. All rights reserved.

  3. The basic study of a bi-material range compensator for improving dose uniformity for proton therapy

    Energy Technology Data Exchange (ETDEWEB)

    Takada, Yoshihisa; Himukai, Takeshi; Takizawa, Kenji; Terashita, Yohsuke; Kamimura, Satoshi; Matsuda, Hiroshi; Hotta, Kenji [Institute of Applied Physics, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, Ibaraki 305-8573 (Japan); Kohno, Ryosuke [National Cancer Center Hospital East, 6-5-1, Kashiwanoha, Kashiwa, Chiba 277-8577 (Japan); Komori, Masataka; Kanai, Tatsuaki [National Institute of Radiological Sciences, 4-9-1, Anagawa, Inage-ku, Chiba-shi 263-8555 (Japan)], E-mail: takada@pmrc.tsukuba.ac.jp

    2008-10-07

    A range compensator (abbreviated as a RC hereafter) is used to form a conformal dose distribution for heavy-charged-particle therapy. However, it induces distortion of the dose distribution. The induced inhomogeneity may result in a calibration error of a monitor unit (MU) assigned to a transmission ionization chamber. By using a bi-material RC made from a low-Z material and a high-Z material instead of the regular RC, the dose inhomogeneity has been obviously reduced by equalizing the lateral dose distributions formed by pencil beams traversing elements of the RC with different base thicknesses at the same water-equivalent depth. We designed and manufactured a 4 x 4 matrix-shaped single-material RC and a bi-material RC with the same range losses at corresponding elements of the RCs. The bi-material RC is made from chemical wood (the main chemical component is an ABS resin) as a low-Z material and from brass as a high-Z material. Sixteen segments of the RC are designed so that the range-loss differences of the adjacent segments of the RC range from 0 to 50 mm in steps of 5 mm. We measured dose distributions in water formed by a 160 MeV proton beam traversing the single-material RC or the bi-material RC, using the HIMAC biology beam port. Large dips and bumps were observed in the dose distribution formed by the use of the single-material RC; the dose uniformity has been significantly improved in the target region by the use of the bi-material RC. The improvement has been obtained at the expense of blurring lateral penumbra. For clinical application of this method to a patient with large density inhomogeneity, a simple modification method of the original calculation model has been given.

  4. The basic study of a bi-material range compensator for improving dose uniformity for proton therapy

    Science.gov (United States)

    Takada, Yoshihisa; Himukai, Takeshi; Takizawa, Kenji; Terashita, Yohsuke; Kamimura, Satoshi; Matsuda, Hiroshi; Hotta, Kenji; Kohno, Ryosuke; Komori, Masataka; Kanai, Tatsuaki

    2008-10-01

    A range compensator (abbreviated as a RC hereafter) is used to form a conformal dose distribution for heavy-charged-particle therapy. However, it induces distortion of the dose distribution. The induced inhomogeneity may result in a calibration error of a monitor unit (MU) assigned to a transmission ionization chamber. By using a bi-material RC made from a low-Z material and a high-Z material instead of the regular RC, the dose inhomogeneity has been obviously reduced by equalizing the lateral dose distributions formed by pencil beams traversing elements of the RC with different base thicknesses at the same water-equivalent depth. We designed and manufactured a 4 × 4 matrix-shaped single-material RC and a bi-material RC with the same range losses at corresponding elements of the RCs. The bi-material RC is made from chemical wood (the main chemical component is an ABS resin) as a low-Z material and from brass as a high-Z material. Sixteen segments of the RC are designed so that the range-loss differences of the adjacent segments of the RC range from 0 to 50 mm in steps of 5 mm. We measured dose distributions in water formed by a 160 MeV proton beam traversing the single-material RC or the bi-material RC, using the HIMAC biology beam port. Large dips and bumps were observed in the dose distribution formed by the use of the single-material RC; the dose uniformity has been significantly improved in the target region by the use of the bi-material RC. The improvement has been obtained at the expense of blurring lateral penumbra. For clinical application of this method to a patient with large density inhomogeneity, a simple modification method of the original calculation model has been given.

  5. A Randomized Dose-Ranging Study of Neuropeptide Y in Patients with Posttraumatic Stress Disorder.

    Science.gov (United States)

    Sayed, Sehrish; Van Dam, Nicholas T; Horn, Sarah R; Kautz, Marin M; Parides, Michael; Costi, Sara; Collins, Katherine A; Iacoviello, Brian; Iosifescu, Dan V; Mathé, Aleksander A; Southwick, Steven M; Feder, Adriana; Charney, Dennis S; Murrough, James W

    2018-01-01

    Anxiety and trauma-related disorders are among the most prevalent and disabling medical conditions in the United States, and posttraumatic stress disorder in particular exacts a tremendous public health toll. We examined the tolerability and anxiolytic efficacy of neuropeptide Y administered via an intranasal route in patients with posttraumatic stress disorder. Twenty-six individuals were randomized in a cross-over, single ascending dose study into 1 of 5 cohorts: 1.4 mg (n=3), 2.8 mg (n=6), 4.6 mg (n=5), 6.8 mg (n=6), and 9.6 mg (n=6). Each individual was dosed with neuropeptide Y or placebo on separate treatment days 1 week apart in random order under double-blind conditions. Assessments were conducted at baseline and following a trauma script symptom provocation procedure subsequent to dosing. Occurrence of adverse events represented the primary tolerability outcome. The difference between treatment conditions on anxiety as measured by the Beck Anxiety Inventory and the State-Trait Anxiety Inventory immediately following the trauma script represented efficacy outcomes. Twenty-four individuals completed both treatment days. Neuropeptide Y was well tolerated up to and including the highest dose. There was a significant interaction between treatment and dose; higher doses of neuropeptide Y were associated with a greater treatment effect, favoring neuropeptide Y over placebo on Beck Anxiety Inventory score (F1,20=4.95, P=.038). There was no significant interaction for State-Trait Anxiety Inventory score. Our study suggests that a single dose of neuropeptide Y is well tolerated up to 9.6 mg and may be associated with anxiolytic effects. Future studies exploring the safety and efficacy of neuropeptide Y in stress-related disorders are warranted. The reported study is registered at: http://clinicaltrials.gov (ID: NCT01533519). © The Author(s) 2017. Published by Oxford University Press on behalf of CINP.

  6. Incisor inclination and perceived tooth colour changes.

    Science.gov (United States)

    Ciucchi, Philip; Kiliaridis, Stavros

    2017-10-01

    Social attractiveness is influenced by a variety of different smile-related factors. We evaluated whether the degree of upper central incisor proclination can result in tooth colour change. Forty young adult subjects (20-25 years) in good health with a complete sound dentition were selected. The subjects were seated in standardized light conditions with an above-directed light source. Their natural head position was stated as 0 degrees. To mimic the range of possible anterior torque movements they were asked to tilt their heads upward +15 degrees (upward tilting) and downward -15 degrees (downward tilting). Frontal macro photographs, parallel to the Frankfort plane of the patient's natural head position were taken at the three head angulations (+15, 0, and -15 degrees ). Photographs were analysed for colour differences at the centre of the incisor clinical crowns with a CIE L*a*b* colour model based software. A paired t-test was used to test for significance between each value for each inclination. Differences were found between the CIE L*a*b* colour values for: upward tilting, downward tilting, and -15 to +15 degrees (total tilting) except for b* values for downward tilting. As the inclination of the subject's head changed downward, the upper incisors were retroclined and the CIE L*a*b* values indicated a darker and less green but redder colour component. As the inclination of the subject's head changed upwards the upper incisors were proclined and the L*a*b* values indicated a lighter and less green and yellow but redder and bluer colour component. Proclination of upper incisors caused lighter tooth colour parameters compared to retroclined incisors and colour changes. Orthodontic change of upper incisor inclination may induce alterations on how tooth colour is perceived.

  7. Radiation-induced alterations of the proliferation dynamics of human skin fibroblasts after repeated irradiation in the subtherapeutic dose range

    International Nuclear Information System (INIS)

    Bumann, J.; Santo-Hoeltje, L.; Loeffler, H.; Bamberg, M.; Rodemann, H.P.

    1995-01-01

    The aim of this study was to determine the effect of single and multiple irradiations on the differentiation and proliferation pattern of the stem cell system of human fibroblasts. The pattern of differentiation of fibroblast cultures was analyzed by morphological criteria using colony forming assays. Proliferation rates were assessed by cell counting and measuring the incorporation of BrdU. Ionizing radiation both in low and high dose ranges exerts differential effects on the cellular processes of differentiation and proliferation in human fibroblasts. Single irradiations of fibroblasts in the dose range of 1 to 8 Gy induced terminal differentiation into postmitotic fibrocytes at high percentage level. Irradiation of longterm cultures of fibroblasts with repeated doses of 0.2, 0.6 and 1.0 Gy revealed that only in cultures, which were irradiated repeatedly (x10) with 0.6 and 1.0 Gy a marked reduction of the proliferation capacity was apparent. Inhibition of proliferation by repeated irradiations with cumulative doses up to 10 Gy was not more pronounced as compared to single irradiations. 1. These results of radiation-induced changes in the proliferation and differentiation pattern of cells may be a basis for the understanding of the cellular processes leading to radiation-induced fibrosis and tissue aging. 2. Multiple irradiations with single doses up to 1 Gy and cumulative doses up to 10 Gy did not change the radiosensitivity of fibroblast cultures regarding effects on cell proliferation. (orig.) [de

  8. Dose comparison according to Smooth Thickness application of Range compensator during proton therapy for brain tumor patient

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Tase Woan; Kim, Dae Woong; Kim, Jae Weon; Jeong, Kyeong Sik [Proton Therapy Center, National Cancer Center, Goyang (Korea, Republic of)

    2016-12-15

    Range Compensator used for proton therapy compensates the proton beam dose which delivers to the normal tissues according to the Target's Distal Margin dose. We are going to check the improvement of dose on the target part by comparing the dose of PTV and OAR according to applying in different method of Smooth Thickness of Range Compensator which is used in brain tumor therapy. For 10 brain tumor patients taking proton therapy in National Cancer Center, Apply Smooth Thickness applied in Range Compensator in order from one to five by using Compensator Editor of Eclipse Proton Planning System(Version 10.0, Varian, USA). The therapy plan algorithm used Proton Convolution Superposition(version 8.1.20 or 10.0.28), and we compared Dmax, Dmin, Homogeneity Index, Conformity Index and OAR dose around tumor by applying Smooth Thickness in phase. When Smooth Thickness was applied from one to five, the Dmax of PTV was decreased max 4.3%, minimum at 0.8 and average of 1.81%. Dmin increased max 1.8%, min 1.8% and average. Difference between max dose and minimum dose decreased at max 5.9% min 1.4% and average 2.6%. Homogeneity Index decreased average of 0.018 and Conformity Index didn't had a meaningful change. OAR dose decreased in Brain Stem at max 1.6%, min 0.1% and average 0.6% and in Optic Chiasm max 1.3%, min 0.3%, and average 0.5%. However, patient C and patient E had an increase each 0.3% and 0.6%. Additionally, in Rt. Optic Nerve, there was a decrease at max 1.5%, min 0.3%, and average 0.8%, however, patient B had 0.1% increase. In Lt. Optic Nerve, there was a decrease at max 1.8%, min 0.3%, and average 0.7%, however, patient H had 0.4 increase. As Smooth Thickness of Range Compensator which is used as the proton treatment for brain tumor patients is applied in stages, the resolution of Compensator increased and as a result the most optimized amount of proton beam dose can be delivered. This is considered to be able to irradiate the equal amount at PTV and

  9. Raman micro-spectroscopy analysis of human lens epithelial cells exposed to a low-dose-range of ionizing radiation

    Science.gov (United States)

    Allen, Christian Harry; Kumar, Achint; Qutob, Sami; Nyiri, Balazs; Chauhan, Vinita; Murugkar, Sangeeta

    2018-01-01

    Recent findings in populations exposed to ionizing radiation (IR) indicate dose-related lens opacification occurs at much lower doses (micro-spectroscopy was used to investigate the effects of varying doses of radiation, ranging from 0.01 Gy to 5 Gy, on human lens epithelial (HLE) cells which were chemically fixed 24 h post-irradiation. Raman spectra were acquired from the nucleus and cytoplasm of the HLE cells. Spectra were collected from points in a 3  ×  3 grid pattern and then averaged. The raw spectra were preprocessed and principal component analysis followed by linear discriminant analysis was used to discriminate between dose and control for 0.25, 0.5, 2, and 5 Gy. Using leave-one-out cross-validation accuracies of greater than 74% were attained for each dose/control combination. The ultra-low doses 0.01 and 0.05 Gy were included in an analysis of band intensities for Raman bands found to be significant in the linear discrimination, and an induced repair model survival curve was fit to a band-difference-ratio plot of this data, suggesting HLE cells undergo a nonlinear response to low-doses of IR. A survival curve was also fit to clonogenic assay data done on the irradiated HLE cells, showing a similar nonlinear response.

  10. Raman micro-spectroscopy analysis of human lens epithelial cells exposed to a low-dose-range of ionizing radiation.

    Science.gov (United States)

    Allen, Christian Harry; Kumar, Achint; Qutob, Sami; Nyiri, Balazs; Chauhan, Vinita; Murugkar, Sangeeta

    2018-01-09

    Recent findings in populations exposed to ionizing radiation (IR) indicate dose-related lens opacification occurs at much lower doses (micro-spectroscopy was used to investigate the effects of varying doses of radiation, ranging from 0.01 Gy to 5 Gy, on human lens epithelial (HLE) cells which were chemically fixed 24 h post-irradiation. Raman spectra were acquired from the nucleus and cytoplasm of the HLE cells. Spectra were collected from points in a 3  ×  3 grid pattern and then averaged. The raw spectra were preprocessed and principal component analysis followed by linear discriminant analysis was used to discriminate between dose and control for 0.25, 0.5, 2, and 5 Gy. Using leave-one-out cross-validation accuracies of greater than 74% were attained for each dose/control combination. The ultra-low doses 0.01 and 0.05 Gy were included in an analysis of band intensities for Raman bands found to be significant in the linear discrimination, and an induced repair model survival curve was fit to a band-difference-ratio plot of this data, suggesting HLE cells undergo a nonlinear response to low-doses of IR. A survival curve was also fit to clonogenic assay data done on the irradiated HLE cells, showing a similar nonlinear response.

  11. Insulin aspart has a shorter duration of action than human insulin over a wide dose-range.

    Science.gov (United States)

    Nosek, L; Roggen, K; Heinemann, L; Gottschalk, C; Kaiser, M; Arnolds, S; Heise, T

    2013-01-01

    Regular human insulin (RHI) at high doses shows prolongation of its duration of action potentially leading to late postprandial hypoglycaemia. This study compared late metabolic activity (4-12 and 6-12 h post-dosing) and duration of action (time to reach late half-maximal activity) over a range of doses between insulin aspart (IAsp) and RHI. Pharmacokinetic and pharmacodynamic properties of subcutaneous IAsp and RHI (6, 12 and 24 (I)U) were compared in 16 healthy subjects in this double-blind, randomized, six-way crossover glucose clamp study. With increasing doses of both insulins, metabolic activity, insulin exposure, maximum metabolic effect and maximum serum insulin concentration increased linearly. Late metabolic activity was lower for IAsp than RHI at all doses, reaching statistical significance (p IAsp had a shorter duration of action at all doses (p IAsp, compared with RHI, showed a higher maximum metabolic effect at 12 and 24 (I)U (p IAsp showed a shorter duration of action and, particularly with doses of 12 and 24 (I)U, less late metabolic activity than RHI. These properties might contribute to the lower incidence of hypoglycaemia observed with IAsp versus RHI in clinical trials as lower late metabolic activity should decrease the risk of late postprandial hypoglycaemia. © 2012 Blackwell Publishing Ltd.

  12. Phase I (or phase II) dose-ranging clinical trials: proposal of a two-stage Bayesian design.

    Science.gov (United States)

    Zohar, Sarah; Chevret, Sylvie

    2003-02-01

    We propose a new design for phase I (or phase II) dose-ranging clinical trials aiming at determining a dose of an experimental treatment to satisfy safety (respectively efficacy) requirements, at treating a sufficiently large number of patients to estimate the toxicity (respectively failure) probability of the dose level with a given reliability, and at stopping the trial early if it is likely that no dose is safe (respectively efficacious). A two-stage design was derived from the Continual Reassessment Method (CRM), with implementation of Bayesian criteria to generate stopping rules. A simulation study was conducted to compare the operating characteristics of the proposed two-stage design to those reached by the traditional CRM. Finally, two applications to real data sets are provided.

  13. Personal dose equivalent conversion coefficients for neutron fluence over the energy range of 20-250 MeV.

    Science.gov (United States)

    Olsher, R H; McLean, T D; Justus, A L; Devine, R T; Gadd, M S

    2010-03-01

    Monte Carlo simulations were performed to extend existing neutron personal dose equivalent fluence-to-dose conversion coefficients to an energy of 250 MeV. Presently, conversion coefficients, H(p,slab)(10,alpha)/Phi, are given by ICRP-74 and ICRU-57 for a range of angles of radiation incidence (alpha = 0, 15, 30, 45, 60 and 75 degrees ) in the energy range from thermal to 20 MeV. Standard practice has been to base operational dose quantity calculations 20 MeV. Both light and heavy ions (HIs) (carbon, nitrogen and oxygen recoil nuclei) were transported down to a lower energy limit (1 keV for light ions and 5 MeV for HIs). Track energy below the limit was assumed to be locally deposited. For neutron tracks slab phantom.

  14. Naltrexone and human eating behavior: a dose-ranging inpatient trial in moderately obese men.

    Science.gov (United States)

    Maggio, C A; Presta, E; Bracco, E F; Vasselli, J R; Kissileff, H R; Pfohl, D N; Hashim, S A

    1985-06-01

    To investigate the effects of the long-acting opiate antagonist naltrexone on spontaneous human eating behavior, eight moderately obese male paid volunteers were housed in a hospital metabolic unit for 28 days and offered palatable foods ad lib by a platter service method. Under double-blind conditions, equally divided doses of 100, 200 and 300 mg naltrexone, or an acetaminophen placebo, were administered twice daily in tablet form for 3-day periods each, according to a Latin Square design. The doses of naltrexone resulted in decreases of daily caloric intake from placebo level, but these reductions were neither statistically significant nor dose-related. When the averaged effects of the doses were compared to placebo, five subjects showed intake reductions but the overall intake reduction of 301.5 +/- 198.1 kcal/day (mean +/- SEM) was not statistically significant. Naltrexone administration failed to selectively alter intakes of individual meals and snacks or macronutrient consumption patterns. During active drug periods, subjects lost 0.62 +/- 0.22 lb over 3 days, while during the placebo period, subjects gained 0.46 +/- 0.68 lb. However, there was no reliable change of basal metabolic rate as a function of naltrexone administration. The present results, which indicate that naltrexone administration is relatively ineffective in reducing food intake and inducing body weight loss in obese humans, are thus in contrast with reports that administration of opiate antagonist agents promote significant reductions of food intake and attenuations of body weight gain in experimental animals.

  15. Thermo-economic performance of inclined solar water distillation systems

    Directory of Open Access Journals (Sweden)

    Agboola Phillips O.

    2015-01-01

    Full Text Available This study investigates the thermo-economic performance of different configurations of inclined solar water desalination for parameters such as daily production, efficiency, system cost and distilled water production cost. The four different configurations considered for this study are as follows; 1. Inclined solar water distillation with bare absorber plate (IISWD with daily production of 5.46 kg/m2 day and daily efficiency of 48.3%. 2. Inclined solar water distillation with wick on absorber plate (IISWDW with daily production of 6.41kg/m2 day and daily efficiency 50.3%. 3. Inclined solar water distillation with wire mesh on absorber plate (IISWDWM with daily production n of 3.03 kg/m2 day and daily efficiency 32.6%. 4. Inclined solar water distillation with bare absorber plate (ISWD. (Control System with daily production of 3.25 kg/m2 day and daily efficiency of 40.1%. The systems potable water cost price ranges from 0.03 $/L for IISWDW to 0.06$/L for IISWDWM System. All the systems are economically and technically feasible as a solar distillation system for potable water in Northern Cyprus. The price of potable water from water vendors/hawkers ranges from 0.11-0.16 $/L. It is more economically viable to have the rooftop inclined solar water desalination system than procuring potable water from vendors.`

  16. Accuracy and Radiation Dose Reduction of Limited-Range CT in the Evaluation of Acute Appendicitis in Pediatric Patients.

    Science.gov (United States)

    Jin, Michael; Sanchez, Thomas R; Lamba, Ramit; Fananapazir, Ghaneh; Corwin, Michael T

    2017-09-01

    The purpose of this article is to determine the accuracy and radiation dose reduction of limited-range CT prescribed from the top of L2 to the top of the pubic symphysis in children with suspected acute appendicitis. We performed a retrospective study of 210 consecutive pediatric patients from December 11, 2012, through December 11, 2014, who underwent abdominopelvic CT for suspected acute appendicitis. Two radiologists independently reviewed the theoretic limited scans from the superior L2 vertebral body to the top of the pubic symphysis, to assess for visualization of the appendix, acute appendicitis, alternative diagnoses, and incidental findings. Separately, the same parameters were assessed on the full scan by the same two reviewers. Whole-body effective doses were determined for the full- and limited-range scans and were compared using the paired t test. The appendix or entire cecum was visualized on the limited scan in all cases, and no cases of acute appendicitis were missed on the simulated limited scan compared with the full scan. Two alternative diagnoses were missed with the limited scan: one case of hydronephrosis and one of acute acalculous cholecystitis. The mean effective dose for the original scan was 5.6 mSv and that for the simulated limited scan was 3.0 mSv, resulting in a dose reduction of 46.4% (p appendicitis and reduces the dose by approximately 46%.

  17. Thermoluminescence and phosphate glass dosimeter systems in the low dose range

    International Nuclear Information System (INIS)

    Piesch, E.; Burgkhardt, B.

    1978-06-01

    This report describes a standard test program for TLD and RPL systems worked out by the Working Party on 'Dose Measurement of External Radiation' by the Fachverband fuer Strahlenschutz e.V. to demonstrate the performance of dosimeter systems to be employed in environmental monitoring and in personnel dosimetry. The results of an intercomparison study are outlined in which 17 laboratories from the German speaking countries participated with 43 dosimeter systems. (orig.) [de

  18. Extending the dose range: Probing deep traps in quartz with 3.06 eV photons

    DEFF Research Database (Denmark)

    Jain, Mayank

    2009-01-01

    This article demonstrates that violet (405 nm) stimulated luminescence (VSL) signal from quartz contains contribution from deep traps that are otherwise not accessible with blue light (470 nm). Additionally, it also contains the typical fast and slow components observed with the blue light...... and blue lights stimulation, and thermal stimulations. Finally, it is shown that the deep traps probed through violet light stimulation have potential for increasing the dose measurement/dating range using quartz. The post-blue VSL signal allows easy, precise measurement of dose up to at least 1 kGy in our...

  19. TRANSIT TIMING VARIATIONS FOR INCLINED AND RETROGRADE EXOPLANETARY SYSTEMS

    International Nuclear Information System (INIS)

    Payne, Matthew J.; Ford, Eric B.; Veras, Dimitri

    2010-01-01

    We perform numerical calculations of the expected transit timing variations (TTVs) induced on a hot-Jupiter by an Earth-mass perturber. Motivated by the recent discoveries of retrograde transiting planets, we concentrate on an investigation of the effect of varying relative planetary inclinations, up to and including completely retrograde systems. We find that planets in low-order (e.g., 2:1) mean-motion resonances (MMRs) retain approximately constant TTV amplitudes for 0 deg. 170 deg. Systems in higher order MMRs (e.g., 5:1) increase in TTV amplitude as inclinations increase toward 45 deg., becoming approximately constant for 45 deg. 135 deg. Planets away from resonance slowly decrease in TTV amplitude as inclinations increase from 0 deg. to 180 deg., whereas planets adjacent to resonances can exhibit a huge range of variability in TTV amplitude as a function of both eccentricity and inclination. For highly retrograde systems (135 deg. < i ≤ 180 deg.), TTV signals will be undetectable across almost the entirety of parameter space, with the exceptions occurring when the perturber has high eccentricity or is very close to an MMR. This high inclination decrease in TTV amplitude (on and away from resonance) is important for the analysis of the known retrograde and multi-planet transiting systems, as inclination effects need to be considered if TTVs are to be used to exclude the presence of any putative planetary companions: absence of evidence is not evidence of absence.

  20. Preliminary evaluation of second harmonic direct detection scheme for low-dose range in alanine/EPR dosimetry

    International Nuclear Information System (INIS)

    Chen, Felipe; Graeff, Carlos F.O.; Baffa, Oswaldo

    2002-01-01

    The usefulness of a direct detection scheme of the second harmonic (2h) overmodulated signal from irradiated alanine in EPR dosimetry was studied. For this purpose, a group of DL-alanine/paraffin cylindrical pellets was produced. The dosimeters were irradiated with a 60 Co radiotherapy gamma source with doses of 0.05, 0.1, 0.5, 1 and 5 Gy. The EPR measurements were carried out in a VARIAN-E4 spectrometer operating in X-band with optimized parameters to obtain highest amplitude signals of both harmonics. The 2h signal was detected directly at twice the modulation frequency. In preliminary results, the 2h showed some advantages over the 1h such as better resolution for doses below 1 Gy, better repeatability results and better linear behaviour in the dose range indicated. (author)

  1. Software to compute and conduct sequential Bayesian phase I or II dose-ranging clinical trials with stopping rules.

    Science.gov (United States)

    Zohar, Sarah; Latouche, Aurelien; Taconnet, Mathieu; Chevret, Sylvie

    2003-10-01

    The aim of dose-ranging phase I (resp. phase II) clinical trials is to rapidly identify the maximum tolerated dose (MTD) (resp., minimal effective dose (MED)) of a new drug or combination. For the conduct and analysis of such trials, Bayesian approaches such as the Continual Reassessment Method (CRM) have been proposed, based on a sequential design and analysis up to a completed fixed sample size. To optimize sample sizes, Zohar and Chevret have proposed stopping rules (Stat. Med. 20 (2001) 2827), the computation of which is not provided by available softwares. We present in this paper a user-friendly software for the design and analysis of these Bayesian Phase I (resp. phase II) dose-ranging Clinical Trials (BPCT). It allows to carry out the CRM with stopping rules or not, from the planning of the trial, with choice of model parameterization based on its operating characteristics, up to the sequential conduct and analysis of the trial, with estimation at stopping of the MTD (resp. MED) of the new drug or combination.

  2. Division probability and division delay in diploid Syrian hamster cells following a range of X-ray doses

    International Nuclear Information System (INIS)

    Joshi, G.P.; Nelson, W.J.; Revell, S.H.; Shaw, C.A.

    1982-01-01

    The first mitotic division probability and division delay of Gl-irradiated Syrian hamster cells (BHK 21 Cl3/A) have been measured following a range of single X-ray doses from 0.2 to 3.8 Gy. Synchronous cell samples were obtained by mitotic selection (mitosis M 0 ) and the data were gathered from visual observations of living cells by methods described in previous papers. The probability of reaching mitosis M 1 remained close to unity in the control cell sample and over the whole dose range (mean > 0.99), and therefore earlier work in the literature showing that cells which lose their clonogenic capacity do so after M 1 and not before it was confirmed. The mean interphase O duration increased linearly with radiation dose, and the regression fit had a slope of 1.32 hours/Gy and a zero-dose value of 10.17 hours. The linear relationship also confirms earlier work, for instance, that based on time-lapse cinemicrography. (author)

  3. Radiolysis of aqueous solutions of ammonium bicarbonate over a large dose range

    DEFF Research Database (Denmark)

    Draganic, Z.D.; Negrón-Mendoza, A.; Sehested, K.

    1991-01-01

    Oxygen-free aqueous solutions of 0.05 mol dm-3 ammonium and sodium bicarbonate were studied after receiving various doses of Co-60 gammas (0.01-400 kGy) or 0.5-20 Gy pulses of 10 Mev electrons. Formate and oxalate were found to be the main radiolytic products, in addition to trace amounts...... to the reformation of bicarbonate, where the reaction COO- + CO3- is particularly significant. Computer fitting of the data obtained gives k(COO- + HCO3-) = (2 +/- 0.4) x 10(3) dm3 mol-1 s-1, k(COO- + CO3-) = (5 +/- 1) x 10(7) dm3 mol-1 s-1, k(NH2 + HCO3-)

  4. Radiation chemistry of aqueous solutions of hydrogen cyanide in the megarad dose range. [. gamma. Radiation

    Energy Technology Data Exchange (ETDEWEB)

    Draganic, Z.D.; Draganic, I.G.; Borovicanin, M.

    1976-04-01

    The radiolytic behavior of HCN was studied in dilute (0.1 M) oxygen-free solutions at their natural pH and at pH 2.4. The solutions were exposed to high doses of /sup 60/Co gamma rays (up to 16 Mrad) causing large decompositions (up to 90 percent). The decomposition yield, G(-HCN), and the radiation-chemical yields of formation of NH/sub 3/, HCHO, H/sub 2/, CO/sub 2/, and of seven amino acids were determined. Also, the total yields of nitrogen in nitrogen-containing nonvolatile compounds, G(N), were measured. The irradiated solutions exhibited positive biuret reaction and the absorbancies depend on both the dose and the initial pH. Histidine, aspartic acid, threonine, serine, glutamic acid, alanine, and glycine were found in irradiated samples. Glycine was found to be the most abundant among the radiolytically produced amino acids; strong acid hydrolysis increases its yield by one or two orders of magnitude in samples irradiated initially at pH 2.4 as well as at their natural pH. The release of amino acids on hydrolysis and the positive biuret reaction suggest the presence of peptidic material in irradiated samples both at acid and neutral pH's. To account for these findings the formation of polymers (or their segments) having a peptidic structure was taken into consideration. The polymerization reactions were assumed to be initiated by the free radicals which were produced by HCN reactions with H, OH, ad e/sub aq/-species. It is concluded that the radiolysis of dilute aqueous solutions of HCN offers significant information on the eventual role of ionizing radiation in prebiotic chemical evolution in aqueous media.

  5. Radiation chemistry of aqueous solutions of hydrogen cyanide in the megarad dose range

    International Nuclear Information System (INIS)

    Draganic, Z.D.; Draganic, I.G.; Borovicanin, M.

    1976-01-01

    The radiolytic behavior of HCN was studied in dilute (0.1 M) oxygen-free solutions at their natural pH and at pH 2.4. The solutions were exposed to high doses of 60 Co gamma rays (up to 16 Mrad) causing large decompositions (up to 90 percent). The decomposition yield, G(-HCN), and the radiation-chemical yields of formation of NH 3 , HCHO, H 2 , CO 2 , and of seven amino acids were determined. Also, the total yields of nitrogen in nitrogen-containing nonvolatile compounds, G(N), were measured. The irradiated solutions exhibited positive biuret reaction and the absorbancies depend on both the dose and the initial pH. Histidine, aspartic acid, threonine, serine, glutamic acid, alanine, and glycine were found in irradiated samples. Glycine was found to be the most abundant among the radiolytically produced amino acids; strong acid hydrolysis increases its yield by one or two orders of magnitude in samples irradiated initially at pH 2.4 as well as at their natural pH. The release of amino acids on hydrolysis and the positive biuret reaction suggest the presence of peptidic material in irradiated samples both at acid and neutral pH's. To account for these findings the formation of polymers (or their segments) having a peptidic structure was taken into consideration. The polymerization reactions were assumed to be initiated by the free radicals which were produced by HCN reactions with H, OH, ad e/sub aq/-species. It is concluded that the radiolysis of dilute aqueous solutions of HCN offers significant information on the eventual role of ionizing radiation in prebiotic chemical evolution in aqueous media

  6. Structural equation modeling for alteration of occlusal plane inclination.

    Science.gov (United States)

    Shigeta, Yuko; Ogawa, Takumi; Nakamura, Yoshiharu; Ando, Eriko; Hirabayashi, Rio; Ikawa, Tomoko

    2015-07-01

    Occlusal plane inclination is important to maintain a normal opening closing/biting function. However, there can be several causes that lead to alterations of the occlusal plane. The purpose of this study was to observe variations of occlusal plane inclination in adult patients, and to uncover the factors affecting changes in occlusal plane inclination with aging. Subjects were 143 patients. A cephalometric image was taken of these patients. In this study, our inquiry points were age, 3 variables on intra-oral findings, and 7 variables on cephalometric analysis. To evaluate the possible causes that affect occlusal plane inclination, factor analysis was carried out, and each component was treated as factors, which were then statistically applied to a structural equation model. Statistical analysis was carried out through the SPSS 20.0 (SPSS Inc., Chicago, USA). In all patients, Camper-occlusal plane angle (COA) ranged from -25.7 to -4.9° (Mean±SD: -6.4±5.36). In the 60 patients who had no missing teeth, COA ranged from -11.6 to -4.9° (Mean±SD: -3.3±3.31). From the results of the structural analysis, it was suggested that the occlusal plane changes to counter-clockwise (on the right lateral cephalograms) with aging. In this study, variations of occlusal plane inclination in adult patients were observed, and the factors affecting changes in occlusal plane inclination with aging were investigated via factor analysis. From our results, it was suggested that the mandibular morphology change and loss of teeth with aging influence occlusal plane inclination. Copyright © 2015 Japan Prosthodontic Society. Published by Elsevier Ltd. All rights reserved.

  7. Clonidine as an adjunct to intravenous regional anesthesia: A randomized, double-blind, placebo-controlled dose ranging study

    Directory of Open Access Journals (Sweden)

    Clarence S Ivie

    2011-01-01

    Full Text Available Background : The addition of clonidine to lidocaine intravenous regional anesthesia (IVRA has been previously reported to improve postoperative analgesia in patients undergoing upper extremity surgery. Our objective was to perform a dose ranging study in order to determine the optimal dose of clonidine used with lidocaine in IVRA. Design & Setting : We performed a double-blinded randomized placebo-controlled study with 60 patients scheduled for elective endoscopic carpal tunnel release under IVRA with 50 ml lidocaine 0.5%. University-affiliated outpatient surgery center. Data collected in operating rooms, recovery room, and by telephone after discharge from surgery center. Materials & Methods : Sixty adult ASA I or II patients undergoing outpatient endoscopic carpal tunnel release under intravenous regional anesthesia.Patients were randomized into five study groups receiving different doses of clonidine in addition to 50 ml 0.5% lidocaine in their IVRA. Group A received 0 mcg/kg, group B 0.25 mcg/kg, group C 0.5 mcg/kg, group D 1.0 mcg/kg and group E 1.5 mcg/kg of clonidine.Intraoperative fentanyl, recovery room pain scores, time to first postsurgical analgesic, total number of acetaminophen/codeine tablets consumed postsurgery, incidence of sedation, hypotension and bradycardia. Results & Conclusions : There was no benefit from any dose of clonidine compared to placebo. There were no clonidine-related side effects seen within the dose range studied. In short duration minor hand surgery, the addition of clonidine to lidocaine-based intravenous regional anesthesia provides no measurable benefit.

  8. Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range

    Directory of Open Access Journals (Sweden)

    Satoko Baba

    2015-03-01

    Full Text Available Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their considerable binding affinity for this receptor in vitro. In the present study, we investigated the D3 receptor binding of blonanserin, a dopamine D2/D3 and serotonin 5-HT2A receptors antagonist, in vitro and in vivo. Blonanserin showed the most potent binding affinity for human D3 receptors among the tested atypical antipsychotics (risperidone, olanzapine and aripiprazole. Our GTPγS-binding assay demonstrated that blonanserin acts as a potent full antagonist for human D3 receptors. All test-drugs exhibited antipsychotic-like efficacy in methamphetamine-induced hyperactivity in rats. Treatment with blonanserin at its effective dose blocked the binding of [3H]-(+-PHNO, a D2/D3 receptor radiotracer, both in the D2 receptor-rich region (striatum and the D3 receptor-rich region (cerebellum lobes 9 and 10. On the other hand, the occupancies of other test-drugs for D3 receptors were relatively low. In conclusion, we have shown that blonanserin, but not other tested antipsychotics, extensively occupies D3 receptors in vivo in rats.

  9. Blonanserin extensively occupies rat dopamine D3 receptors at antipsychotic dose range.

    Science.gov (United States)

    Baba, Satoko; Enomoto, Takeshi; Horisawa, Tomoko; Hashimoto, Takashi; Ono, Michiko

    2015-03-01

    Antagonism of the dopamine D3 receptor has been hypothesized to be beneficial for schizophrenia cognitive deficits, negative symptoms and extrapyramidal symptoms. However, recent animal and human studies have shown that most antipsychotics do not occupy D3 receptors in vivo, despite their considerable binding affinity for this receptor in vitro. In the present study, we investigated the D3 receptor binding of blonanserin, a dopamine D2/D3 and serotonin 5-HT2A receptors antagonist, in vitro and in vivo. Blonanserin showed the most potent binding affinity for human D3 receptors among the tested atypical antipsychotics (risperidone, olanzapine and aripiprazole). Our GTPγS-binding assay demonstrated that blonanserin acts as a potent full antagonist for human D3 receptors. All test-drugs exhibited antipsychotic-like efficacy in methamphetamine-induced hyperactivity in rats. Treatment with blonanserin at its effective dose blocked the binding of [(3)H]-(+)-PHNO, a D2/D3 receptor radiotracer, both in the D2 receptor-rich region (striatum) and the D3 receptor-rich region (cerebellum lobes 9 and 10). On the other hand, the occupancies of other test-drugs for D3 receptors were relatively low. In conclusion, we have shown that blonanserin, but not other tested antipsychotics, extensively occupies D3 receptors in vivo in rats. Copyright © 2015 Japanese Pharmacological Society. Production and hosting by Elsevier B.V. All rights reserved.

  10. Efficacy of mizoribine followed by low-dose prednisone in patients with idiopathic membranous nephropathy and nephrotic-range proteinuria.

    Science.gov (United States)

    Matsumoto, Yoshihiro; Shimada, Yasushi; Nojima, Youichi; Moriki, Toshiaki

    2013-08-01

    Idiopathic membranous nephropathy (IMN) patients with persistent high-grade proteinuria are at the highest risk for developing end-stage renal failure. We previously reported the effects of treatment with mizoribine followed by low-dose prednisone treatment in 4 IMN patients. The purpose of the present study was to further assess the effects of this combined treatment in a larger study group. Thirteen patients with IMN and nephrotic-range proteinuria received combined treatment. Mizoribine was initiated at a dose of 150 mg/day, and 2-3 months later, 20 mg/day prednisone was added to the mizoribine regimen. The dosage of prednisone and/or mizoribine was tapered according to the urinary protein-to-creatinine ratio (P/C). We evaluated patient responses for up to 12 months after the initiation of combination therapy. Before treatment, patient urinary P/C ranged from 3.7 to 15.9 g/g. Although these values did not decrease during mizoribine monotherapy, all patients showed dramatic P/C decreases over the course of combination therapy. At 3, 6, and 12 months after combination therapy, 15%, 31%, and 62% of patients attained complete remission, respectively, and all patients were in partial or complete remission 6 months after combination therapy. No notable side effects were observed. The addition of prednisone after mizoribine monotherapy can be beneficial for all IMN patients with nephrotic-range proteinuria syndrome. The risks associated with immunotherapy can be decreased by initially prescribing mizoribine alone, which might act as a base for establishing therapy, followed by low-dose prednisone treatment.

  11. On liquid films on an inclined plate

    KAUST Repository

    BENILOV, E. S.

    2010-08-18

    This paper examines two related problems from liquid-film theory. Firstly, a steady-state flow of a liquid film down a pre-wetted plate is considered, in which there is a precursor film in front of the main film. Assuming the former to be thin, a full asymptotic description of the problem is developed and simple analytical estimates for the extent and depth of the precursor film\\'s influence on the main film are provided. Secondly, the so-called drag-out problem is considered, where an inclined plate is withdrawn from a pool of liquid. Using a combination of numerical and asymptotic means, the parameter range where the classical Landau-Levich-Wilson solution is not unique is determined. © 2010 Cambridge University Press.

  12. Sexual dimorphism and regional variation in human frontal bone inclination measured via digital 3D models.

    Science.gov (United States)

    Petaros, Anja; Garvin, Heather M; Sholts, Sabrina B; Schlager, Stefan; Wärmländer, Sebastian K T S

    2017-11-01

    The frontal bone is one of the most sexually dimorphic elements of the human skull, due to features such as the glabella, frontal eminences, and frontal inclination. While glabella is frequently evaluated in procedures to estimate sex in unknown human skeletal remains, frontal inclination has received less attention. In this study we present a straightforward, quick, and reproducible method for measuring frontal inclination angles from glabella and supraglabella. Using a sample of 413 human crania from four different populations (U.S. Whites, U.S. Blacks, Portuguese, and Chinese), we test the usefulness of the inclination angles for sex estimation and compare their performance to traditional methods of frontal inclination assessment. Accuracy rates in the range 75-81% were achieved for the U.S. White, U.S. Black, and Portuguese groups. For Chinese the overall accuracy was lower, i.e. 66%. Although some regional variation was observed, a cut-off value of 78.2° for glabellar inclination angles separates female and male crania from all studied populations with good accuracy. As inclination angles measured from glabella captures two sexually dimorphic features (i.e. glabellar prominence and frontal inclination) in a single measure, the observed clear male/female difference is not unexpected. Being continuous variables, inclination angles are suitable for use in statistical methods for sex estimations. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Dose-response relationships for the onset of avoidance of sonar by free-ranging killer whales.

    Science.gov (United States)

    Miller, Patrick J O; Antunes, Ricardo N; Wensveen, Paul J; Samarra, Filipa I P; Alves, Ana Catarina; Tyack, Peter L; Kvadsheim, Petter H; Kleivane, Lars; Lam, Frans-Peter A; Ainslie, Michael A; Thomas, Len

    2014-02-01

    Eight experimentally controlled exposures to 1-2 kHz or 6-7 kHz sonar signals were conducted with four killer whale groups. The source level and proximity of the source were increased during each exposure in order to reveal response thresholds. Detailed inspection of movements during each exposure session revealed sustained changes in speed and travel direction judged to be avoidance responses during six of eight sessions. Following methods developed for Phase-I clinical trials in human medicine, response thresholds ranging from 94 to 164 dB re 1 μPa received sound pressure level (SPL) were fitted to Bayesian dose-response functions. Thresholds did not consistently differ by sonar frequency or whether a group had previously been exposed, with a mean SPL response threshold of 142 ± 15 dB (mean ± s.d.). High levels of between- and within-individual variability were identified, indicating that thresholds depended upon other undefined contextual variables. The dose-response functions indicate that some killer whales started to avoid sonar at received SPL below thresholds assumed by the U.S. Navy. The predicted extent of habitat over which avoidance reactions occur depends upon whether whales responded to proximity or received SPL of the sonar or both, but was large enough to raise concerns about biological consequences to the whales.

  14. Experimental Study of Natural Convection Cooling of Vertical Cylinders with Inclined Plate Fins

    Directory of Open Access Journals (Sweden)

    Jong Bum Lee

    2016-05-01

    Full Text Available In this paper, natural convection from vertical cylinders with inclined plate fins is investigated experimentally for use in cooling electronic equipment. Extensive experimental investigations are performed for various inclination angles, fin numbers, and base temperatures. From the experimental data, a correlation for estimating the Nusselt number is proposed. The correlation is applicable when the Rayleigh number, inclination angle, and fin number are in the ranges 100,000–600,000, 30°–90°, and 9–36, respectively. Using the correlation, a contour map depicting the thermal resistance as a function of the fin number and fin thickness is presented. Finally, the optimal thermal resistances of cylinders with inclined plate fins and conventional radial plate fins are compared. It is found that that the optimal thermal resistance of the cylinder with inclined fins is 30% lower than that of the cylinder with radial plate fins.

  15. How do the substrate reaction forces acting on a gecko's limbs respond to inclines?

    Science.gov (United States)

    Wang, Zhouyi; Dai, Zhendong; Li, Wei; Ji, Aihong; Wang, Wenbao

    2015-02-01

    Locomotion is an essential character of animals, and excellent moving ability results from the delicate sensing of the substrate reaction forces (SRF) acting on body and modulating the behavior to adapt the motion requirement. The inclined substrates present in habitats pose a number of functional challenges to locomotion. In order to effectively overcome these challenges, climbing geckos execute complex and accurate movements that involve both the front and hind limbs. Few studies have examined gecko's SRF on steeper inclines of greater than 90°. To reveal how the SRFs acting on the front and hind limbs respond to angle incline changes, we obtained detailed measurements of the three-dimensional SRFs acting on the individual limbs of the tokay gecko while it climbed on an inclined angle of 0-180°. The fore-aft forces acting on the front and hind limbs show opposite trends on inverted inclines of greater than 120°, indicating propulsion mechanism changes in response to inclines. When the incline angles change, the forces exerted in the normal and fore-aft directions by gecko's front and hind limbs are reassigned to take full advantage of limbs' different roles in overcoming resistance and in propelling locomotion. This also ensures that weight acts in the angle range between the forces generated by the front and hind limbs. The change in the distribution of SRF with a change in the incline angle is directly linked to the favorable trade-off between locomotive maneuverability and stability.

  16. Comparison of patient specific dose metrics between chest radiography, tomosynthesis, and CT for adult patients of wide ranging body habitus

    International Nuclear Information System (INIS)

    Zhang, Yakun; Li, Xiang; Segars, W. Paul; Samei, Ehsan

    2014-01-01

    Purpose: Given the radiation concerns inherent to the x-ray modalities, accurately estimating the radiation doses that patients receive during different imaging modalities is crucial. This study estimated organ doses, effective doses, and risk indices for the three clinical chest x-ray imaging techniques (chest radiography, tomosynthesis, and CT) using 59 anatomically variable voxelized phantoms and Monte Carlo simulation methods. Methods: A total of 59 computational anthropomorphic male and female extended cardiac-torso (XCAT) adult phantoms were used in this study. Organ doses and effective doses were estimated for a clinical radiography system with the capability of conducting chest radiography and tomosynthesis (Definium 8000, VolumeRAD, GE Healthcare) and a clinical CT system (LightSpeed VCT, GE Healthcare). A Monte Carlo dose simulation program (PENELOPE, version 2006, Universitat de Barcelona, Spain) was used to mimic these two clinical systems. The Duke University (Durham, NC) technique charts were used to determine the clinical techniques for the radiographic modalities. An exponential relationship between CTDI vol and patient diameter was used to determine the absolute dose values for CT. The simulations of the two clinical systems compute organ and tissue doses, which were then used to calculate effective dose and risk index. The calculation of the two dose metrics used the tissue weighting factors from ICRP Publication 103 and BEIR VII report. Results: The average effective dose of the chest posteroanterior examination was found to be 0.04 mSv, which was 1.3% that of the chest CT examination. The average effective dose of the chest tomosynthesis examination was found to be about ten times that of the chest posteroanterior examination and about 12% that of the chest CT examination. With increasing patient average chest diameter, both the effective dose and risk index for CT increased considerably in an exponential fashion, while these two dose metrics

  17. Comparison of patient specific dose metrics between chest radiography, tomosynthesis, and CT for adult patients of wide ranging body habitus.

    Science.gov (United States)

    Zhang, Yakun; Li, Xiang; Segars, W Paul; Samei, Ehsan

    2014-02-01

    Given the radiation concerns inherent to the x-ray modalities, accurately estimating the radiation doses that patients receive during different imaging modalities is crucial. This study estimated organ doses, effective doses, and risk indices for the three clinical chest x-ray imaging techniques (chest radiography, tomosynthesis, and CT) using 59 anatomically variable voxelized phantoms and Monte Carlo simulation methods. A total of 59 computational anthropomorphic male and female extended cardiac-torso (XCAT) adult phantoms were used in this study. Organ doses and effective doses were estimated for a clinical radiography system with the capability of conducting chest radiography and tomosynthesis (Definium 8000, VolumeRAD, GE Healthcare) and a clinical CT system (LightSpeed VCT, GE Healthcare). A Monte Carlo dose simulation program (PENELOPE, version 2006, Universitat de Barcelona, Spain) was used to mimic these two clinical systems. The Duke University (Durham, NC) technique charts were used to determine the clinical techniques for the radiographic modalities. An exponential relationship between CTDIvol and patient diameter was used to determine the absolute dose values for CT. The simulations of the two clinical systems compute organ and tissue doses, which were then used to calculate effective dose and risk index. The calculation of the two dose metrics used the tissue weighting factors from ICRP Publication 103 and BEIR VII report. The average effective dose of the chest posteroanterior examination was found to be 0.04 mSv, which was 1.3% that of the chest CT examination. The average effective dose of the chest tomosynthesis examination was found to be about ten times that of the chest posteroanterior examination and about 12% that of the chest CT examination. With increasing patient average chest diameter, both the effective dose and risk index for CT increased considerably in an exponential fashion, while these two dose metrics only increased slightly for

  18. Comparison of patient specific dose metrics between chest radiography, tomosynthesis, and CT for adult patients of wide ranging body habitus

    Energy Technology Data Exchange (ETDEWEB)

    Zhang, Yakun [Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Li, Xiang [Medical Physics Graduate Program, Department of Physics, Cleveland State University, Cleveland, Ohio 44115 (United States); Segars, W. Paul [Medical Physics Graduate Program, Carl E. Ravin Advanced Imaging Laboratories, and Department of Radiology, Duke University Medical Center, Durham, North Carolina 27705 (United States); Samei, Ehsan, E-mail: samei@duke.edu [Medical Physics Graduate Program, Carl E. Ravin Advanced Imaging Laboratories, Department of Radiology, Departments of Physics, Biomedical Engineering, and Electrical and Computer Engineering, Duke University Medical Center, Durham, North Carolina 27705 (United States)

    2014-02-15

    Purpose: Given the radiation concerns inherent to the x-ray modalities, accurately estimating the radiation doses that patients receive during different imaging modalities is crucial. This study estimated organ doses, effective doses, and risk indices for the three clinical chest x-ray imaging techniques (chest radiography, tomosynthesis, and CT) using 59 anatomically variable voxelized phantoms and Monte Carlo simulation methods. Methods: A total of 59 computational anthropomorphic male and female extended cardiac-torso (XCAT) adult phantoms were used in this study. Organ doses and effective doses were estimated for a clinical radiography system with the capability of conducting chest radiography and tomosynthesis (Definium 8000, VolumeRAD, GE Healthcare) and a clinical CT system (LightSpeed VCT, GE Healthcare). A Monte Carlo dose simulation program (PENELOPE, version 2006, Universitat de Barcelona, Spain) was used to mimic these two clinical systems. The Duke University (Durham, NC) technique charts were used to determine the clinical techniques for the radiographic modalities. An exponential relationship between CTDI{sub vol} and patient diameter was used to determine the absolute dose values for CT. The simulations of the two clinical systems compute organ and tissue doses, which were then used to calculate effective dose and risk index. The calculation of the two dose metrics used the tissue weighting factors from ICRP Publication 103 and BEIR VII report. Results: The average effective dose of the chest posteroanterior examination was found to be 0.04 mSv, which was 1.3% that of the chest CT examination. The average effective dose of the chest tomosynthesis examination was found to be about ten times that of the chest posteroanterior examination and about 12% that of the chest CT examination. With increasing patient average chest diameter, both the effective dose and risk index for CT increased considerably in an exponential fashion, while these two dose

  19. The response of TL lithium fluoride detectors to 24 GeV/c protons for doses ranging up to 1 MGy

    CERN Document Server

    Obryk, B; Olko, P; Pajor, A; Glaser, M; Budzanowski, M; Bilski, P

    2010-01-01

    A new method of thermoluminescent (TL) measurement of radiation doses ranging from micrograys up to a megagray has been recently developed at IFJ. This method is based on a newly discovered behavior of LiF:Mg,Cu,P detectors at doses exceeding 1 kGy. Significant changes in their glow-curves are observed at higher doses; of special importance is occurrence of a new, well separated peak for doses above 50 kGy, thus these detectors can be used for measurements of doses at ultra-high dose range. In order to check the glow-curve features in the high dose region for different types of LiF:Mg,Cu,P and LiF:Mg,Ti detectors after irradiation with heavy charged particles, tests at the 24 GeV/c proton beam of IRRAD1 irradiation zone at the CERN Proton Synchrotron accelerator up to 1 MGy were performed. The occurrence of the high dose peak in the glow-curve of LiF:Mg,Cu,P detectors resulting from heavy particles irradiation was confirmed. Results of this investigation are presented in this paper. (C) 2010 Elsevier Ltd. All...

  20. Radiation impact in the low dose range. What we know, what we do not know; Strahlenwirkung im niedrigen Dosisbereich. Was wir wissen, was wir nicht wissen

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, W.U. [Inst. fuer Medizinische Strahlenbiologie, Univ. Essen (Germany)

    2009-07-01

    We know rather well radiation risk of doses exceeding about 100 mSv (adults) and 10 mSv (fetuses). Below these doses we have to make (plausible) assumptions, because epidemiology can give only limited advice due to the high statistical variability of the data. In radiation protection one uses the LNT (linear non-threshold) model, meaning a linear extrapolation starting in the medium dose range without the assumption of a threshold dose. As this model has been repeated so often, many individuals meanwhile think that it has been ''proven''. This is not the case. Opinions can be different within limits. Instead of linear, the course of dose response curves may be linear-quadratic, supra-linear, with a threshold or even with a protective effect. We know that numerous biological mechanisms affect the shape of the dose-response relations in the low-dose range, like adaptive response, bystander effect, genetic predisposition, genomic instability, immunological effects, repair. The idea is to analyse these mechanisms extensively and to estimate risk based on the summary of the single dose effect relationships. It is crucially important to include all mechanisms and not to base conclusions on single, selected mechanisms. (orig.)

  1. A jig for measuring incisor inclination.

    Science.gov (United States)

    Shah, N; Spary, D J; Rock, W P

    2005-06-01

    The aim of this study was to design and construct a jig for measuring the inclination of the upper incisors to the maxillary plane and of the lower incisors to the mandibular plane. After several prototypes had been tested, the required properties for a successful jig were identified and a simple inexpensive device was produced. Measurements obtained when using the jig on 51 subjects were compared with cephalometric values by means of regression analysis. This revealed that measurements obtained using the jig against the upper and then the lower incisor crowns could be converted to cephalometric incisor angulations with 96 per cent accuracy to 10 degrees, by adding 23 and 3 degrees, respectively. The jig was accurate to 5 degrees on 69 per cent of occasions for the upper teeth. The 5 degrees accuracy with the lower incisors was only 27 per cent, although over a 6 degree range it improved to 78 per cent. For upper and lower tooth measurements combined, the jig was accurate to within 6 degrees on 75 per cent of occasions.

  2. A Broad Range of Dose Optima Achieve High-level, Long-term Gene Expression After Hydrodynamic Delivery of Sleeping Beauty Transposons Using Hyperactive SB100x Transposase

    Directory of Open Access Journals (Sweden)

    Kelly M Podetz-Pedersen

    2016-01-01

    Full Text Available The Sleeping Beauty (SB transposon system has been shown to enable long-term gene expression by integrating new sequences into host cell chromosomes. We found that the recently reported SB100x hyperactive transposase conferred a surprisingly high level of long-term expression after hydrodynamic delivery of luciferase-encoding reporter transposons in the mouse. We conducted dose-ranging studies to determine the effect of varying the amount of SB100x transposase-encoding plasmid (pCMV-SB100x at a set dose of luciferase transposon and of varying the amount of transposon-encoding DNA at a set dose of pCMV-SB100x in hydrodynamically injected mice. Animals were immunosuppressed using cyclophosphamide in order to prevent an antiluciferase immune response. At a set dose of transposon DNA (25 µg, we observed a broad range of pCMV-SB100x doses (0.1–2.5 µg conferring optimal levels of long-term expression (>1011 photons/second/cm2. At a fixed dose of 0.5 μg of pCMV-SB100x, maximal long-term luciferase expression (>1010 photons/second/cm2 was achieved at a transposon dose of 5–125 μg. We also found that in the linear range of transposon doses (100 ng, co-delivering the CMV-SB100x sequence on the same plasmid was less effective in achieving long-term expression than delivery on separate plasmids. These results show marked flexibility in the doses of SB transposon plus pCMV-SB100x that achieve maximal SB-mediated gene transfer efficiency and long-term gene expression after hydrodynamic DNA delivery to mouse liver.

  3. Calorimetry for dose measurement at electron accelerators in the 80-120 keV energy range

    DEFF Research Database (Denmark)

    Helt-Hansen, J.; Miller, A.; Duane, S.

    2005-01-01

    Calorimeters for dose measurement at low-energy electron accelerator energies (80-120 keV) are described. Three calorimeters with different characteristics were designed and their dose response and measurement uncertainties were characterized. The heated air between the beam exit window...... and the calorimeter absorber influences significantly the response of the calorimeter and a thermal model was applied to quantify this effect. All three calorimeters are capable of measuring absolute dose, and can thus be used for calibration of other dosimeters. (C) 2005 Elsevier Ltd. All rights reserved....

  4. Locomotor Behavior of Chickens Anticipating Incline Walking

    Directory of Open Access Journals (Sweden)

    Chantal LeBlanc

    2018-01-01

    Full Text Available Keel bone damage (KBD is prevalent in hens raised for egg production, and ramps between different tiers in aviaries have potential to reduce the frequency of falls resulting in KBD. Effective use of ramps requires modulation of locomotion in anticipation of the incline. Inadequate adaptive locomotion may be one explanation why domestic layer hens (Gallus gallus domesticus exhibit high rates of KBD. To improve understanding of the capacity of hens to modulate their locomotion in anticipation of climbing, we measured the effects of incline angle upon the mechanics of the preparatory step before ascending a ramp. Because the energetic challenge of climbing increases with slope, we predicted that as angle of incline increased, birds during foot contact with the ground before starting to climb would increase their peak force and duration of contact and reduce variation in center of pressure (COP under their foot. We tested 20 female domestic chickens on ramp inclines at slopes of +0°, +40°, and +70° when birds were 17, 21, 26, 31, and 36 weeks of age. There were significantly higher vertical peak ground reaction forces in preparation at the steepest slope, and ground contact time increased significantly with each increase in ramp angle. Effects upon variation in COP were not apparent; likewise, effects of limb length, age, body mass were not significant. Our results reveal that domestic chickens are capable of modulating their locomotion in response to incline angle.

  5. Generation of inclined protoplanetary discs and misaligned planets through mass accretion - I. Coplanar secondary discs

    Science.gov (United States)

    Xiang-Gruess, M.; Kroupa, P.

    2017-10-01

    We study the three-dimensional (3D) evolution of a viscous protoplanetary disc that accretes gas material from a second protoplanetary disc during a close encounter in an embedded star cluster. The aim is to investigate the capability of the mass accretion scenario to generate strongly inclined gaseous discs that could later form misaligned planets. We use smoothed particle hydrodynamics to study mass transfer and disc inclination for passing stars and circumstellar discs with different masses. We explore different orbital configurations to find the parameter space that allows significant disc inclination generation. Thies et al. suggested that significant disc inclination and disc or planetary system shrinkage can generally be produced by the accretion of external gas material with a different angular momentum. We found that this condition can be fulfilled for a large range of gas mass and angular momentum. For all encounters, mass accretion from the secondary disc increases with decreasing mass of the secondary proto-star. Thus, higher disc inclinations can be attained for lower secondary stellar masses. Variations of the secondary disc's orientation relative to the orbital plane can alter the disc evolution significantly. The results taken together show that mass accretion can change the 3D disc orientation significantly resulting in strongly inclined discs. In combination with the gravitational interaction between the two star-disc systems, this scenario is relevant for explaining the formation of highly inclined discs that could later form misaligned planets.

  6. Phase 2 Randomized, Dose-Ranging Study of Oxymetazoline Cream for Treatment of Persistent Facial Erythema Associated With Rosacea.

    Science.gov (United States)

    DuBois, Janet; Dover, Jeffrey S; Jones, Terry M; Weiss, Robert A; Berk, David R; Ahluwalia, Gurpreet

    2018-03-01

    Rosacea is a chronic dermatologic condition with limited treatment options. This phase 2 study evaluated the optimal oxymetazoline dosing regimen in patients with moderate to severe persistent facial erythema of rosacea. Patients were randomly assigned to oxymetazoline cream, 0.5%, 1.0%, or 1.5%, or vehicle, administered once daily (QD) or twice daily (BID) for 28 consecutive days. The primary efficacy endpoint was the proportion of patients with ≥2-grade improvement from baseline on the Clinician Erythema Assessment (CEA) and the Subject Self-Assessment of erythema (SSA-1) on day 28. Safety assessments included treatment-emergent adverse events and dermal tolerability. A total of 356 patients were treated (mean age, 50.0 years; 80.1% female). The proportions of patients achieving the primary endpoint were significantly higher with oxymetazoline 0.5% QD (P=0.049), 1.0% QD (P=0.006), 1.5% QD (P=0.012), 1.0% BID (P=0.021), and 1.5% BID (P=0.006) versus their respective vehicles. For both QD and BID dosing, the efficacy of oxymetazoline 1.0% was greater than the 0.5% dose and comparable to the 1.5% dose. Safety and application-site tolerability were similar across groups. Short-term treatment period. Oxymetazoline 1.0% QD provided the optimal dosing regimen and was selected for evaluation in phase 3 clinical studies. J Drugs Dermatol. 2018;17(3):308-316.

  7. Inclined nanoimprinting lithography for 3D nanopatterning

    International Nuclear Information System (INIS)

    Liu Zhan; Bucknall, David G; Allen, Mark G

    2011-01-01

    We report a non-conventional shear-force-driven nanofabrication approach, inclined nanoimprint lithography (INIL), for producing 3D nanostructures of varying heights on planar substrates in a single imprinting step. Such 3D nanostructures are fabricated by exploiting polymer anisotropic dewetting where the degree of anisotropy can be controlled by the magnitude of the inclination angle. The feature size is reduced from micron scale of the template to a resultant nanoscale pattern. The underlying INIL mechanism is investigated both experimentally and theoretically. The results indicate that the shear force generated at a non-zero inclination angle induced by the INIL apparatus essentially leads to asymmetry in the polymer flow direction ultimately resulting in 3D nanopatterns with different heights. INIL removes the requirements in conventional nanolithography of either utilizing 3D templates or using multiple lithographic steps. This technique enables various 3D nanoscale devices including angle-resolved photonic and plasmonic crystals to be fabricated.

  8. SU-E-J-146: A Research of PET-CT SUV Range for the Online Dose Verification in Carbon Ion Radiation Therapy

    International Nuclear Information System (INIS)

    Sun, L; Hu, W; Moyers, M; Zhao, J; Hsi, W

    2015-01-01

    Purpose: Positron-emitting isotope distributions can be used for the image fusion of the carbon ion planning CT and online target verification PETCT, after radiation in the same decay period,the relationship between the same target volume and the SUV value of different every single fraction dose can be found,then the range of SUV for the radiation target could be decided.So this online range also can provide reference for the correlation and consistency in planning target dose verification and evaluation for the clinical trial. Methods: The Rando head phantom can be used as real body,the 10cc cube volume target contouring is done,beam ISO Center depth is 7.6cm and the 90 degree fixed carbon ion beams should be delivered in single fraction effective dose of 2.5GyE,5GyE and 8GyE.After irradiation,390 seconds later the 30 minutes PET-CT scanning is performed,parameters are set to 50Kg virtual weight,0.05mCi activity.MIM Maestro is used for the image processing and fusion,five 16mm diameter SUV spheres have been chosen in the different direction in the target.The average SUV in target for different fraction dose can be found by software. Results: For 10cc volume target,390 seconds decay period,the Single fraction effective dose equal to 2.5Gy,Ethe SUV mean value is 3.42,the relative range is 1.72 to 6.83;Equal to 5GyE,SUV mean value is 9.946,the relative range is 7.016 to 12.54;Equal or above to 8GyE,SUV mean value is 20.496,the relative range is 11.16 to 34.73. Conclusion: Making an evaluation for accuracy of the dose distribution using the SUV range which is from the planning CT with after treatment online PET-CT fusion for the normal single fraction carbon ion treatment is available.Even to the plan which single fraction dose is above 2GyE,in the condition of other parameters all the same,the SUV range is linearly dependent with single fraction dose,so this method also can be used in the hyper-fraction treatment plan

  9. Drop impact and rebound dynamics on an inclined superhydrophobic surface.

    Science.gov (United States)

    Yeong, Yong Han; Burton, James; Loth, Eric; Bayer, Ilker S

    2014-10-14

    Due to its potential in water-repelling applications, the impact and rebound dynamics of a water drop impinging perpendicular to a horizontal superhydrophobic surface have undergone extensive study. However, drops tend to strike a surface at an angle in applications. In such cases, the physics governing the effects of oblique impact are not well studied or understood. Therefore, the objective of this study was to conduct an experiment to investigate the impact and rebound dynamics of a drop at various liquid viscosities, in an isothermal environment, and on a nanocomposite superhydrophobic surface at normal and oblique impact conditions (tilted at 15°, 30°, 45°, and 60°). This study considered drops falling from various heights to create normal impact Weber numbers ranging from 6 to 110. In addition, drop viscosity was varied by decreasing the temperature for water drops and by utilizing water-glycerol mixtures, which have similar surface tension to water but higher viscosities. Results revealed that oblique and normal drop impact behaved similarly (in terms of maximum drop spread as well as rebound dynamics) at low normal Weber numbers. However, at higher Weber numbers, normal and oblique impact results diverged in terms of maximum spread, which could be related to asymmetry and more complex outcomes. These asymmetry effects became more pronounced as the inclination angle increased, to the point where they dominated the drop impact and rebound characteristics when the surface was inclined at 60°. The drop rebound characteristics on inclined surfaces could be classified into eight different outcomes driven primarily by normal Weber number and drop Ohnesorge numbers. However, it was found that these outcomes were also a function of the receding contact angle, whereby reduced receding angles yielded tail-like structures. Nevertheless, the contact times of the drops with the coating were found to be generally independent of surface inclination.

  10. Two Mechanisms of Sensorimotor Set Adaptation to Inclined Stance

    Directory of Open Access Journals (Sweden)

    Kyoung-Hyun Lee

    2017-10-01

    Full Text Available Orientation of posture relative to the environment depends on the contributions from the somatosensory, vestibular, and visual systems mixed in varying proportions to produce a sensorimotor set. Here, we probed the sensorimotor set composition using a postural adaptation task in which healthy adults stood on an inclined surface for 3 min. Upon returning to a horizontal surface, participants displayed a range of postural orientations – from an aftereffect that consisted of a large forward postural lean to an upright stance with little or no aftereffect. It has been hypothesized that the post-incline postural change depends on each individual’s sensorimotor set: whether the set was dominated by the somatosensory or vestibular system: Somatosensory dominance would cause the lean aftereffect whereas vestibular dominance should steer stance posture toward upright orientation. We investigated the individuals who displayed somatosensory dominance by manipulating their attention to spatial orientation. We introduced a distraction condition in which subjects concurrently performed a difficult arithmetic subtraction task. This manipulation altered the time course of their post-incline aftereffect. When not distracted, participants returned to upright stance within the 3-min period. However, they continued leaning forward when distracted. These results suggest that the mechanism of sensorimotor set adaptation to inclined stance comprises at least two components. The first component reflects the dominant contribution from the somatosensory system. Since the postural lean was observed among these subjects even when they were not distracted, it suggests that the aftereffect is difficult to overcome. The second component includes a covert attentional component which manifests as the dissipation of the aftereffect and the return of posture to upright orientation.

  11. Breakwaters with Vertical and Inclined Concrete Walls

    DEFF Research Database (Denmark)

    Burcharth, Hans Falk

    Following the PIANC PTC II working group on Analyses of Rubble Mound Breakwaters it was, in 1991, decided to form Working Group (WG) n° 28 on "Breakwaters with vertical and inclined concrete walls" The scope of the work was to achieve a better understanding of the overall safety aspects in the de......Following the PIANC PTC II working group on Analyses of Rubble Mound Breakwaters it was, in 1991, decided to form Working Group (WG) n° 28 on "Breakwaters with vertical and inclined concrete walls" The scope of the work was to achieve a better understanding of the overall safety aspects...

  12. Electrophysical properties of silicon layers implanted with erbium and oxygen ions over a wide dose range and heat treated with different temperature regimes

    CERN Document Server

    Aleksandrov, O V; Sobolev, N A; Nikolaev, Y A

    2002-01-01

    The electrophysical properties of silicon implanted with erbium and oxygen ions over a wide dose range have been studied. The electron mobility dependence on the electrically active center concentration has been obtained in erbium-doped silicon with a concentration varied over 9 x 10 sup 1 sup 5 - 8 x 10 sup 1 sup 6 cm sup - sup 3 range. In the concentration profiles of electrically active centers n(x) and erbium atoms C(x), irregularities related to some peculiarities of the Er segregation during solid phase epitaxial recrystallization were found. They are regarded as peculiar to erbium ion implantation doses higher than the amorphization thresholds. A linear increase of a maximum concentration of electrically active centers and practically constant effective coefficient k of their activation have been observed at the erbium ion implantation doses higher than the amorphization threshold. An increase in the electrically active center concentration gains saturation and k drops at the erbium concentration highe...

  13. Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)

    DEFF Research Database (Denmark)

    Nguyen, Quan Dong; Schachar, Ronald A; Nduaka, Chudy I

    2012-01-01

    To evaluate the safety and efficacy of three doses of PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene, for the treatment of diabetic macular edema (DME) compared to focal/grid laser photocoagulation....

  14. Effect of a simple two-step warfarin dosing algorithm on anticoagulant control as measured by time in therapeutic range : a pilot study

    NARCIS (Netherlands)

    Kim, Y. -K.; Nieuwlaat, R.; Connolly, S. J.; Schulman, S.; Meijer, K.; Raju, N.; Kaatz, S.; Eikelboom, J. W.

    Background: The efficacy and safety of vitamin K antagonists for the prevention of thromboembolism are dependent on the time for which the International Normalized Ratio (INR) is in the therapeutic range. The objective of our study was to determine the effect of introducing a simple two-step dosing

  15. A randomized, double-blind, placebo-controlled, dose-ranging study using Genz-644470 and sevelamer carbonate in hyperphosphatemic chronic kidney disease patients on hemodialysis

    Directory of Open Access Journals (Sweden)

    Moustafa M

    2014-04-01

    Full Text Available Moustafa Moustafa,1 Lawrence Lehrner,2 Fahd Al-Saghir,3 Mark Smith,4 Sunita Goyal,5 Maureen Dillon,5 John Hunter,5 Randy Holmes-Farley5 1South Carolina Nephrology and Hypertension Center Inc., Orangeburg, SC, USA; 2Kidney Specialists of Southern Nevada, Las Vegas, NV, USA; 3Michigan Kidney Consultants, Pontiac, MI, USA; 4Kidney Care Associates, LLC, Augusta, GA, USA; 5Genzyme, a Sanofi company, Cambridge, MA, USA Background: Genz-644470 is a new, nonabsorbed phosphate binding polymer. In an in vitro competitive phosphate binding assay, Genz-644470 bound significantly more phosphate per gram than sevelamer. As a consequence, this clinical study evaluated the ability of Genz-644470 to lower serum phosphorus in patients on hemodialysis and compared serum phosphorus lowering of Genz-644470 with sevelamer carbonate and placebo. Because three different fixed doses of Genz-644470 and sevelamer carbonate were used, phosphate-lowering dose-responses of each agent were also analyzed. Methods: A randomized, double-blind, dose-ranging study was conducted. After a 2-week phosphate binder washout, 349 hyperphosphatemic (serum phosphorus >5.5 mg/dL hemodialysis patients were randomized to one of seven fixed-dose groups: placebo, Genz-644470 2.4 g/day, Genz-644470 4.8 g/day, Genz-644470 7.2 g/day, sevelamer carbonate 2.4 g/day, sevelamer carbonate 4.8 g/day, or sevelamer carbonate 7.2 g/day. Indicated total daily doses were administered in fixed divided doses three times a day with meals for 3 weeks. The change in serum phosphorus during the treatment period and its dose-response patterns were assessed. Results: Dose-dependent reductions in serum phosphorus were observed with both Genz-644470 and sevelamer carbonate. Serum phosphorus-lowering responses to fixed doses of sevelamer carbonate and Genz-644470 were enhanced in a roughly linear fashion with increasing doses over a threefold range after 3 weeks of treatment. Genz-644470 did not show any advantage in

  16. Internally cooled V-shape inclined monochromator

    Czech Academy of Sciences Publication Activity Database

    Oberta, Peter; Áč, V.; Hrdý, Jaromír

    2008-01-01

    Roč. 15, - (2008), 8-11 ISSN 0909-0495 R&D Projects: GA AV ČR IAA100100716 Grant - others:VEGA(SK) 1/4134/07 Institutional research plan: CEZ:AV0Z10100522 Keywords : inclined monochromator * heat load * internal cooling Subject RIV: BH - Optics, Masers, Lasers Impact factor: 2.333, year: 2008

  17. A matter of chance, environment and inclination

    Indian Academy of Sciences (India)

    Lawrence

    Why did I opt for science subjects in school, and choose a career in science? Perhaps the best answer would be. 'Chance, Environment and Inclination'. Here I am, considered to be a professional woman scien- tist, working towards understanding the biology of the malaria parasite and the challenges put up by the same.

  18. Inclined test of nacelle wind lidar

    DEFF Research Database (Denmark)

    Courtney, Michael

    A nacelle wind lidar, placed at ground level, is tested by inclining the laser beams to bisect a measurement mast at a known distance and height. The horizontal wind speed reported by the lidar is compared to a reference cup anemometer mounted on the mast at the comparison height....

  19. Vehicle with inclinable caterpillar propulsion units

    International Nuclear Information System (INIS)

    Clar, G.

    1991-01-01

    This vehicle usable in hostile environment such nuclear industry has four propulsion units with a caterpillar track and two integrated motors: one for advancing the caterpillar track and the other for inclining the propulsion unit when overcoming obstacles. Each propulsion unit is easily replaceable because there are no mechanical parts in the body of the vehicle [fr

  20. The influence of non-radiation induced ESR background signal from paraffin-alanine probes for dosimetry in the radiotherapy dose range

    International Nuclear Information System (INIS)

    Wieser, A.; Lettau, C.; Fill, U.; Regulla, D.F.

    1993-01-01

    The yield of radicals induced by ionizing radiation in the amino acid alanine and its quantification by ESR spectroscopy has proven excellent reproducibility. Those radicals trapped in the crystal lattice are prevented from recombination providing a thermally very stable system. This allows alanine to be applied as a transfer dosemeter. With paraffin-alanine probes ESR dosimetry can be performed with a standard deviation of ± 0.5% in the dose range from 20 Gy up to 100 kGy. At 1 Gy dose level the error increases to ± 6%. This dose level is three orders of magnitude higher than the calculated detection threshold for alanine with modern X-band ESR spectrometers. It was found that the poor standard deviation at the 1 Gy dose level, is not mainly produced by a bad signal-to-noise ratio but by a variable non-radiation induced ESR background signal from the alanine probes within a batch. In the present study the main sources of error for ESR dosimetry in the dose range below 20 Gy were analyzed. The influences of the production process, UV light and humidity upon the ESR background signal from paraffin-alanine probes were investigated. Measurements are shown indicating a second stable structure of the alanine radical at room temperature. (author)

  1. A secular model for efficient exploration of mutually-inclined planetary systems

    Science.gov (United States)

    Deitrick, Russell; Barnes, Rory

    2015-01-01

    Dynamical studies of exoplanets largely assume coplanarity because of the lack of inclination information in many cases. However, the multiplanet system Upsilon Andromedae has orbital planes inclined by 30 degrees, models of planet-planet scattering predict large mutual inclinations, and astrometry missions such as Gaia have the power to reveal the 3 dimensional architecture of planetary systems. As the dynamics of systems with non-planar orbits will be key to understanding origins, and ultimately habitability where applicable, we present a computationally efficient model for the orbital evolution of planetary systems with modest inclinations and eccentricities which are not in a mean motion resonance. Specifically, our model is based on the disturbing function and extends to 4th order in eccentricity and inclination. We present comparisons to N-body models for known systems, such as the Solar System and Upsilon Andromedae, and hypothetical systems with a range of orbital configurations. We describe the eccentricity and inclination conditions under which the model is valid. We further calculate the rotational evolution of planets based on the orbital evolution and the stellar torque and find a wide range of obliquity evolution is possible. As obliquity is a key driver of planetary climate, Earth-like planets in non-planar systems may have climates dominated by their orbital evolution.

  2. Alanine-EPR dosimetry for measurements of ionizing radiation absorbed doses in the range 0.5-10 kGy

    CERN Document Server

    Peimel-Stuglik, Z

    2001-01-01

    The usefulness of two, easy accessible alanine dosimeters (ALANPOL from IChTJ and foil dosimeter from Gamma Service, Radeberg, Germany) to radiation dose measurement in the range of 0.5-10 kGy, were investigated. In both cases, the result of the test was positive. The foil dosemeter from Gamma Service is recommended for dose distribution measurements in fantoms or products, ALANPOL - for routine measurements. The EPR-alanine method based on the described dosimeters can be successfully used, among others, in the technology of radiation protection of food.

  3. A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study of AST-120 (Kremezin) in patients with moderate to severe CKD.

    Science.gov (United States)

    Schulman, Gerald; Agarwal, Rajiv; Acharya, Muralidhar; Berl, Tomas; Blumenthal, Samuel; Kopyt, Nelson

    2006-04-01

    AST-120 (Kremezin; Kureha Chemical Industry Co Ltd, Tokyo, Japan) is an orally administered adsorbent showing adsorption ability superior to activated charcoal for certain organic compounds known to be precursors of substances that accumulate in patients with chronic kidney disease (CKD) and that are believed to accelerate the decline in kidney function. AST-120 is approved in Japan for prolonging time to hemodialysis therapy and improving uremic symptoms in patients with CKD. A multicenter, randomized, double-blind, placebo-controlled, dose-ranging study was designed to examine the nephroprotective effects of 3 doses of AST-120 versus placebo in adult patients with moderate to severe CKD and elevated serum indoxyl sulfate levels while following an adequate protein-intake diet. Eligible patients were randomly assigned to 1 of 3 doses of AST-120 (0.9, 2.1, or 3.0 g) or placebo 3 times daily for 12 weeks. AST-120 decreased serum indoxyl sulfate levels in a dose-dependent fashion. During the 12-week treatment period, AST-120 did not affect serum creatinine levels or 24-hour urine creatinine appearance. Significant improvements in malaise were observed in a dose-dependent fashion. All doses of AST-120 were well tolerated and did not adversely affect the general health status of patients. Results suggest that the dose of 3 g 3 times daily is an optimal dose for the US population, and it may be useful in the treatment of patients with CKD. Because AST-120 did not directly affect serum creatinine levels or 24-hour urine creatinine appearance, the composite end point of doubling of serum creatinine level, transplantation, and dialysis therapy would be appropriate for a confirmatory phase III therapeutic outcome study.

  4. Randomized dose-ranging controlled trial of AQ-13, a candidate antimalarial, and chloroquine in healthy volunteers.

    Science.gov (United States)

    Mzayek, Fawaz; Deng, Haiyan; Mather, Frances J; Wasilevich, Elizabeth C; Liu, Huayin; Hadi, Christiane M; Chansolme, David H; Murphy, Holly A; Melek, Bekir H; Tenaglia, Alan N; Mushatt, David M; Dreisbach, Albert W; Lertora, Juan J L; Krogstad, Donald J

    2007-01-05

    To determine: (1) the pharmacokinetics and safety of an investigational aminoquinoline active against multidrug-resistant malaria parasites (AQ-13), including its effects on the QT interval, and (2) whether it has pharmacokinetic and safety profiles similar to chloroquine (CQ) in humans. Phase I double-blind, randomized controlled trials to compare AQ-13 and CQ in healthy volunteers. Randomizations were performed at each step after completion of the previous dose. Tulane-Louisiana State University-Charity Hospital General Clinical Research Center in New Orleans. 126 healthy adults 21-45 years of age. 10, 100, 300, 600, and 1,500 mg oral doses of CQ base in comparison with equivalent doses of AQ-13. Clinical and laboratory adverse events (AEs), pharmacokinetic parameters, and QT prolongation. No hematologic, hepatic, renal, or other organ toxicity was observed with AQ-13 or CQ at any dose tested. Headache, lightheadedness/dizziness, and gastrointestinal (GI) tract-related symptoms were the most common AEs. Although symptoms were more frequent with AQ-13, the numbers of volunteers who experienced symptoms with AQ-13 and CQ were similar (for AQ-13 and CQ, respectively: headache, 17/63 and 10/63, p = 0.2; lightheadedness/dizziness, 11/63 and 8/63, p = 0.6; GI symptoms, 14/63 and 13/63; p = 0.9). Both AQ-13 and CQ exhibited linear pharmacokinetics. However, AQ-13 was cleared more rapidly than CQ (respectively, median oral clearance 14.0-14.7 l/h versus 9.5-11.3 l/h; p < or = 0.03). QTc prolongation was greater with CQ than AQ-13 (CQ: mean increase of 28 ms; 95% confidence interval [CI], 18 to 38 ms, versus AQ-13: mean increase of 10 ms; 95% CI, 2 to 17 ms; p = 0.01). There were no arrhythmias or other cardiac AEs with either AQ-13 or CQ. These studies revealed minimal differences in toxicity between AQ-13 and CQ, and similar linear pharmacokinetics.

  5. Quantifying the spatial and temporal variation in dose from external exposure to radiation: a new tool for use on free-ranging wildlife

    International Nuclear Information System (INIS)

    Hinton, Thomas G.; Byrne, Michael E.; Webster, Sarah; Beasley, James C.

    2015-01-01

    Inadequate dosimetry is often the fundamental problem in much of the controversial research dealing with radiation effects on free-ranging wildlife. Such research is difficult because of the need to measure dose from several potential pathways of exposure (i.e., internal contamination, external irradiation, and inhalation). Difficulties in quantifying external exposures can contribute significantly to the uncertainties of dose-effect relationships. Quantifying an animal's external exposure due to spatial–temporal use of habitats that can vary by orders of magnitude in radiation levels is particularly challenging. Historically, wildlife dosimetry studies have largely ignored or been unable to accurately quantify variability in external dose because of technological limitations. The difficulties of quantifying the temporal–spatial aspects of external irradiation prompted us to develop a new dosimetry instrument for field research. We merged two existing technologies [Global Positioning Systems (GPS) and electronic dosimeters] to accommodate the restrictive conditions of having a combined unit small enough to be unobtrusively worn on the neck of a free-ranging animal, and sufficiently robust to withstand harsh environmental conditions. The GPS–dosimeter quantifies the spatial and temporal variation in external dose as wildlife traverse radioactively contaminated habitats and sends, via satellites, an animal's location and short term integrated dose to the researcher at a user-defined interval. Herein we describe: (1) the GPS–dosimeters; (2) tests to compare their uniformity of response to external irradiation under laboratory conditions; (3) field tests of their durability when worn on wildlife under natural conditions; and (4) a field application of the new technology at a radioactively contaminated site. Use of coupled GPS–dosimetry will allow, for the first time, researchers to better understand the relationship of animals to their contaminated

  6. Evaluation of GAFCHROMIC EBT2 dosimetry for the low dose range using a flat-bed scanner with the reflection mode

    International Nuclear Information System (INIS)

    Gotanda, Tatsuhiro; Katsuda, Toshizo; Akagawa, Takuya; Gotanda, Rumi; Tabuchi, Akihiko; Yamamoto, Kenyu; Kuwano, Tadao; Takedo, Yoshihiro; Yatake, Hidetoshi; Yabunaka, Koichi

    2013-01-01

    Recently developed radiochromic films can easily be used to measure absorbed doses because they do not need development processing and indicate a density change that depends on the absorbed dose. However, in GAFCHROMIC EBT2 dosimetry (GAF-EBT2) as a radiochromic film, the precision of the measurement was compromised, because of non-uniformity problems caused by image acquisition using a flat-bed scanner with a transmission mode. The purpose of this study was to improve the precision of the measurement using a flat-bed scanner with a reflection mode at the low absorbed dose dynamic range of GAF-EBT2. The calibration curves of the absorbed dose versus the film density for GAF-EBT2 were provided. X-rays were exposed in the range between ~0 and 120 mGy in increments of about 12 mGy. The results of the method using a flat-bed scanner with the transmission mode were compared with those of the method using the same scanner with the reflection mode. The results should that the determination coefficients (r 2 ) for the straight-line approximation of the calibration curve using the reflection mode were higher than 0.99, and the gradient using the reflection mode was about twice that of the one using the transmission mode. The non-uniformity error that is produced by a flat-bed scanner with the transmission mode setting could be almost eliminated by converting from the transmission mode to the reflection mode. In light of these findings, the method using a flat-bed scanner with the reflection mode (only using uniform white paper) improved the precision of the measurement for the low absorbed dose range.

  7. Granular flow down a flexible inclined plane

    Directory of Open Access Journals (Sweden)

    Sonar Prasad

    2017-01-01

    Full Text Available Discrete and continuous systems are commonly studied individually, but seldom together. Indeed, granular flows are typically studied through flows over a rigid base. Here, we investigate the behaviour of granular flows over an inclined, flexible base. The flexible base is modeled as a rigid platform mounted on springs and has one degree of freedom. The base vibrations are introduced by the flow. We simulate such flows through a discrete element method and compare with experiments. We find that a flexible base increased the upper limit of the inclination up to which a steady flow is possible by at least 3 degrees. This stabilized zone may have important implications in applications such as conveyor belts and chutes.

  8. Granular flow down a flexible inclined plane

    Science.gov (United States)

    Sonar, Prasad; Sharma, Ishan; Singh, Jayant

    2017-06-01

    Discrete and continuous systems are commonly studied individually, but seldom together. Indeed, granular flows are typically studied through flows over a rigid base. Here, we investigate the behaviour of granular flows over an inclined, flexible base. The flexible base is modeled as a rigid platform mounted on springs and has one degree of freedom. The base vibrations are introduced by the flow. We simulate such flows through a discrete element method and compare with experiments. We find that a flexible base increased the upper limit of the inclination up to which a steady flow is possible by at least 3 degrees. This stabilized zone may have important implications in applications such as conveyor belts and chutes.

  9. Stress field of a dislocating inclined fault

    Energy Technology Data Exchange (ETDEWEB)

    Huang, F.; Wang, T.

    1980-02-01

    Analytical expressions are derived for the stress field caused by a rectangular dislocating fault of an arbitrary dip in a semi-infinite elastic medium for the case of unequal Lame constants. The results of computations for the stress fields on the ground surface of an inclined strike-slip and an inclined dip-slip fault are represented by contour maps. The effects of Poisson Ratio of the medium, the dip angle, upper and lower boundaries of the faults on the stress field at surface have been discussed. As an application, the contour maps for shear stress and hydrostatic stress of near fields of the Tonghai (1970), Haicheng (1975) and Tangshan (1976) earthquakes have been calculated and compared with the spatial distributions of strong aftershocks of these earthquakes. It is found that most of the strong aftershocks are distributed in the regions of tensional stress, where the hydrostatic stress is positive.

  10. Stress field of a dislocating inclined fault

    Energy Technology Data Exchange (ETDEWEB)

    Huang, F.; Wang, T.

    1980-02-01

    In this paper, analytical expressions of the stress field given rise by a rectangular dislocating fault of an arbitrary dip in a semi-infinite elastic medium for the case of unequal Lame constants are derived. The results of computations for the stress fields on the ground surface of an inclined strike-slip and an inclined dip-slip fault are represented by contour maps. The effects of the Poisson Ratio of the medium, the dip angle, upper and lower boundaries of the faults on the stress field at the surface have been discussed. As an application, the contour maps for shear stress and hydrostatic stress of near fields of the Tonghai (1970), Haicheng, (1975) and Tangshan (1976) earthquakes have been calculated and compared with the spatial distributions of strong aftershocks of these earthquakes. It is found that most of the strong aftershocks are distributed in the regions of tensional stress where the hydrostatic stress is positive.

  11. Bubble streams rising beneath an inclined surface

    Science.gov (United States)

    Bird, James; Brasz, Frederik; Kim, Dayoung; Menesses, Mark; Belden, Jesse

    2017-11-01

    Bubbles released beneath a submerged inclined surface can tumble along the wall as they rise, dragging the surrounding fluid with them. This effect has recently regained attention as a method to mitigate biofouling in marine environment, such as a ship hull. It appears that the efficacy of this approach may be related to the velocity of the rising bubbles and the extent that they spread laterally as they rise. Yet, it is unclear how bubble stream rise velocity and lateral migration depend on bubble size, flow rate, and inclination angle. Here we perform systematic experiments to quantify these relationships for both individual bubble trajectories and ensemble average statistics. Research supported by the Office of Naval Research under Grant Number award N00014-16-1-3000.

  12. HIGH-INCLINATION ASTEROID FAMILIES V1.0

    Data.gov (United States)

    National Aeronautics and Space Administration — This data set contains the high-inclination asteroid families of Gil-Hutton (2006). A data set of 3652 high-inclination numbered asteroids was analyzed to search for...

  13. Tooth Wear Inclination in Great Ape Molars.

    Science.gov (United States)

    Knight-Sadler, Jordan; Fiorenza, Luca

    2017-01-01

    Primate dietary diversity is reflected in their dental morphology, with differences in size and shape of teeth. In particular, the tooth wear angle can provide insight into a species' ability to break down certain foods. To examine dietary and masticatory information, digitized polygon models of dental casts provide a basis for quantitative analysis of wear associated with tooth attrition. In this study, we analyze and compare the wear patterns of Pongo pygmaeus, Gorilla gorillagorilla and Pan troglodytes schweinfurthii lower molars, focusing on the degree of inclination of specific wear facets. The variation in wear angles appears to be indicative of jaw movements and the specific stresses imposed on food during mastication, reflecting thus the ecology of these species. Orangutans exhibit flatter wear angles, more typical of a diet consisting of hard and brittle foods, while gorillas show a wear pattern with a high degree of inclination, reflecting thus their more leafy diet. Chimpanzees, on the other hand, show intermediate inclinations, a pattern that could be related to their highly variable diet. This method is demonstrated to be a powerful tool for better understanding the relationship between food, mastication and tooth wear processes in living primates, and can be potentially used to reconstruct the diet of fossil species. © 2017 S. Karger AG, Basel.

  14. A jumping cylinder in an incline

    Science.gov (United States)

    Gomez, Raul W.; Hernandez, Jorge; Marquina, Vivianne

    2012-02-01

    The problem of a cylinder of mass m and radius r, with its center of mass out of the cylinder axis, rolling in an incline that makes an angle α respect to the horizontal is analyzed. The equation of motion is solved to obtain the site where the cylinder loses contact with the incline (jumps). Several simplifications are made: the analyzed system consists of an homogeneous disc with a one dimensional straight line of mass parallel to the disc axis at a distance d Styrofoam cylinder of radius r = 10.0 ± 0.05 cm, high h = 5.55 ± 0.05 cm and a mass m1 = 24.45 ± 0.05 g, to which a 9.50 ± 0.01 mm diameter and 5.10 ± 0.001 cm long brass road of mass m2 = 30.75 ± 0.05 g was imbibed parallel to the disc axis at a distance of 5.40 ± 0.05 cm from it. Then the disc rolls on a 3.20 m long wooden ramp inclined at 30 and 45 respect to the horizontal. To determine the jumping site, the movements were recorded with a high-speed video camera (Casio EX ZR100) at 400 frames per second. The experimental results agree well with the theoretical predictions.

  15. Irradiation Creep of Ferritic-Martensitic Steels EP-450, EP-823 and EI-852 Irradiated in the BN-350 Reactor over Wide Ranges of Irradiation Temperature and Dose

    International Nuclear Information System (INIS)

    Porollo, S.I.; Konobeev, Y.V.; Ivanov, A.A.; Shulepin, S.V.; Garner, F.

    2007-01-01

    Full text of publication follows: Ferritic/martensitic (F/M) steels appear to be the most promising materials for advanced nuclear systems, especially for fusion reactors. Their main advantages are higher resistance to swelling and lower irradiation creep rate as has been repeatedly demonstrated in examinations of these materials after irradiation. Nevertheless, available experimental data on irradiation resistance of F/M steels are insufficient, with the greatest deficiency of data for high doses and for both low and high irradiation temperatures. From the very beginning of operation the BN-350 fast reactor has been used for irradiation of specimens of structural materials, including F/M steels. The most unique feature of BN-350 was its low inlet sodium temperature, allowing irradiation at temperatures over a very wide range of temperatures compared with the range in other fast reactors. In this paper data are presented on swelling and irradiation creep of three Russian F/M steels EP-450, EP-823 and EI-852, irradiated in experimental assemblies of the BN-350 reactor at temperatures in the range of 305-700 deg. C to doses ranging from 20 to 89 dpa. The investigation was performed using gas-pressurized creep tubes with hoop stresses in the range of 0 - 294 MPa. (authors)

  16. Precession of a Spinning Ball Rolling down an Inclined Plane

    Science.gov (United States)

    Cross, Rod

    2015-01-01

    A routine problem in an introductory physics course considers a rectangular block at rest on a plane inclined at angle a to the horizontal. In order for the block not to slide down the incline, the coefficient of sliding friction, µ, must be at least tan a. The situation is similar for the case of a ball rolling down an inclined plane. In order…

  17. A randomized, double-blind, placebo-controlled, dose-ranging trial of tafenoquine for weekly prophylaxis against Plasmodium falciparum.

    Science.gov (United States)

    Hale, Braden R; Owusu-Agyei, Seth; Fryauff, David J; Koram, Kwadwo A; Adjuik, Martin; Oduro, Abraham R; Prescott, W Roy; Baird, J Kevin; Nkrumah, Francis; Ritchie, Thomas L; Franke, Eileen D; Binka, Fred N; Horton, John; Hoffman, Stephen L

    2003-03-01

    Tafenoquine is a promising new 8-aminoquinoline drug that may be useful for malaria prophylaxis in nonpregnant persons with normal glucose-6-phosphate dehydrogenase (G6PD) function. A randomized, double-blind, placebo-controlled chemoprophylaxis trial was conducted with adult residents of northern Ghana to determine the minimum effective weekly dose of tafenoquine for the prevention of infection by Plasmodium falciparum. The primary end point was a positive malaria blood smear result during the 13 weeks of study drug coverage. Relative to the placebo, all 4 tafenoquine dosages demonstrated significant protection against P. falciparum infection: for 25 mg/week, protective efficacy was 32% (95% confidence interval [CI], 20%-43%); for 50 mg/week, 84% (95% CI, 75%-91%); for 100 mg/week, 87% (95% CI, 78%-93%); and for 200 mg/week, 86% (95% CI, 76%-92%). The mefloquine dosage of 250 mg/week also demonstrated significant protection against P. falciparum infection (protective efficacy, 86%; 95% CI, 72%-93%). There was little difference between study groups in the adverse events reported, and there was no evidence of a relationship between tafenoquine dosage and reports of physical complaints or the occurrence of abnormal laboratory parameters. Tafenoquine dosages of 50, 100, and 200 mg/week were safe, well tolerated, and effective against P. falciparum infection in this study population.

  18. Pool Boiling CHF in Inclined Narrow Annuli

    International Nuclear Information System (INIS)

    Kang, Myeong Gie

    2010-01-01

    Pool boiling heat transfer has been studied extensively since it is frequently encountered in various heat transfer equipment. Recently, it has been widely investigated in nuclear power plants for application to the advanced light water reactors designs. Through the review on the published results it can be concluded that knowledge on the combined effects of the surface orientation and a confined space on pool boiling heat transfer is of great practical importance and also of great academic interest. Fujita et al. investigated pool boiling heat transfer, from boiling inception to the critical heat flux (CHF, q' CHF ), in a confined narrow space between heated and unheated parallel rectangular plates. They identified that both the confined space and the surface orientation changed heat transfer much. Kim and Suh changed the surface orientation angles of a downward heating rectangular channel having a narrow gap from the downward-facing position (180 .deg.) to the vertical position (90 .deg.). They observed that the CHF generally decreased as the inclination angle (θ ) increased. Yao and Chang studied pool boiling heat transfer in a confined heat transfer for vertical narrow annuli with closed bottoms. They observed that when the gap size ( s ) of the annulus was decreased the effect of space confinement to boiling heat transfer increased. The CHF was occurred at much lower value for the confined space comparing to the unconfined pool boiling. Pool boiling heat transfer in narrow horizontal annular crevices was studied by Hung and Yao. They concluded that the CHF decreased with decreasing gap size of the annuli and described the importance of the thin film evaporation to explain the lower CHF of narrow crevices. The effect of the inclination angle on the CHF on countercurrent boiling in an inclined uniformly heated tube with closed bottoms was also studied by Liu et al. They concluded that the CHF reduced with the inclination angle decrease. A study was carried out

  19. Radiological dose assessment for residual radioactive material in soil at the clean slate sites 1, 2, and 3, Tonopah Test Range

    International Nuclear Information System (INIS)

    1997-06-01

    A radiological dose assessment has been performed for Clean Slate Sites 1, 2, and 3 at the Tonopah Test Range, approximately 390 kilometers (240 miles) northwest of Las Vegas, Nevada. The assessment demonstrated that the calculated dose to hypothetical individuals who may reside or work on the Clean Slate sites, subsequent to remediation, does not exceed the limits established by the US Department of Energy for protection of members of the public and the environment. The sites became contaminated as a result of Project Roller Coaster experiments conducted in 1963 in support of the US Atomic Energy Commission (Shreve, 1964). Remediation of Clean Slate Sites 1, 2, and 3 is being performed to ensure that the 50-year committed effective dose equivalent to a hypothetical individual who lives or works on a Clean Slate site should not exceed 100 millirems per year. The DOE residual radioactive material guideline (RESRAD) computer code was used to assess the dose. RESRAD implements the methodology described in the DOE manual for establishing residual radioactive material guidelines (Yu et al., 1993a). In May and June of 1963, experiments were conducted at Clean Slate Sites 1, 2, and 3 to study the effectiveness of earth-covered structures for reducing the dispersion of nuclear weapons material as a result of nonnuclear explosions. The experiments required the detonation of various simulated weapons using conventional chemical explosives (Shreve, 1964). The residual radioactive contamination in the surface soil consists of weapons grade plutonium, depleted uranium, and their radioactive decay products

  20. Radiological dose assessment for residual radioactive material in soil at the clean slate sites 1, 2, and 3, Tonopah Test Range

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    A radiological dose assessment has been performed for Clean Slate Sites 1, 2, and 3 at the Tonopah Test Range, approximately 390 kilometers (240 miles) northwest of Las Vegas, Nevada. The assessment demonstrated that the calculated dose to hypothetical individuals who may reside or work on the Clean Slate sites, subsequent to remediation, does not exceed the limits established by the US Department of Energy for protection of members of the public and the environment. The sites became contaminated as a result of Project Roller Coaster experiments conducted in 1963 in support of the US Atomic Energy Commission (Shreve, 1964). Remediation of Clean Slate Sites 1, 2, and 3 is being performed to ensure that the 50-year committed effective dose equivalent to a hypothetical individual who lives or works on a Clean Slate site should not exceed 100 millirems per year. The DOE residual radioactive material guideline (RESRAD) computer code was used to assess the dose. RESRAD implements the methodology described in the DOE manual for establishing residual radioactive material guidelines (Yu et al., 1993a). In May and June of 1963, experiments were conducted at Clean Slate Sites 1, 2, and 3 to study the effectiveness of earth-covered structures for reducing the dispersion of nuclear weapons material as a result of nonnuclear explosions. The experiments required the detonation of various simulated weapons using conventional chemical explosives (Shreve, 1964). The residual radioactive contamination in the surface soil consists of weapons grade plutonium, depleted uranium, and their radioactive decay products.

  1. Two dose-ranging studies with PF-04937319, a systemic partial activator of glucokinase, as add-on therapy to metformin in adults with type 2 diabetes.

    Science.gov (United States)

    Amin, N B; Aggarwal, N; Pall, D; Paragh, G; Denney, W S; Le, V; Riggs, M; Calle, R A

    2015-08-01

    To assess the efficacy and safety of a range of doses of a systemic, partial, glucokinase activator, PF-04937319, as add-on therapy to metformin, in patients with type 2 diabetes mellitus (T2DM). Patients were randomized to once-daily PF-04937319 doses of 10, 50, 100 mg, or matching placebo (Study B1621002); or PF-04937319 doses of 3, 20, 50, 100 mg, or matching placebo (Study B1621007). Titrated glimepiride (Study B1621002) or sitagliptin (Study B1621007) were included in a double-dummy manner. The primary measure was change from baseline in glycated haemoglobin (HbA1c) at week 12. Key secondary measures included other glycaemic variables and safety and tolerability. In the 639 patients randomized, the minimally efficacious PF-04937319 dose was identified as 50 mg once daily. At the highest PF-04937319 dose tested (100 mg), on average, a clinically significant reduction in HbA1c [-4.94 or -5.11 mmol/mol (-0.45 or -0.47%), placebo-adjusted], which was similar to that achieved with sitagliptin [-4.69 mmol/mol (-0.43%)] but lower than that achieved with titrated glimepiride [-9.07 mmol/mol (-0.83%)], was observed. At this dose, the effect on fasting plasma glucose was not consistent between the two studies (Study B1621002 vs Study B1621007: placebo-adjusted mean change of -0.83 vs +0.50 mmol/l). PF-04937319 was well tolerated at doses up to 100 mg. Hypoglycaemia was reported in 2.5% of patients (on placebo), 5.1% of patients (on PF-04937319 100 mg), 1.8% of patients (on sitagliptin) and 34.4% of patients (on titrated glimepiride). In patients on metformin monotherapy, the addition of a 100-mg dose of PF-04937319 improved glycaemic control and was well tolerated. © 2015 John Wiley & Sons Ltd.

  2. Efficacy of a dose range of simulated sunlight exposures in raising vitamin D status in South Asian adults: implications for targeted guidance on sun exposure.

    Science.gov (United States)

    Farrar, Mark D; Webb, Ann R; Kift, Richard; Durkin, Marie T; Allan, Donald; Herbert, Annie; Berry, Jacqueline L; Rhodes, Lesley E

    2013-06-01

    Vitamin D is essential for bone health, and cutaneous synthesis is an important source. South Asians cannot attain adequate amounts of vitamin D by following general recommendations on summer sunlight exposure at northerly latitudes, and increased exposure may be appropriate for improving their vitamin D status. We examined the efficacy of a dose range of simulated summer sunlight exposures in raising vitamin D status in UK adults of South Asian ethnicity. In a dose-response study, healthy adults of South Asian ethnicity (n = 60; 20-60 y old) received 1 of 6 ultraviolet exposures ranging from 0.65 to 3.9 standard erythema doses (SEDs), which were equivalent to 15-90 min unshaded noontime summer sunlight at 53.5°N (Manchester, United Kingdom), 3 times/wk for 6 wk, while wearing casual clothes that revealed a 35% skin area. Serum 25-hydroxyvitamin D [25(OH)D] was measured weekly, and dietary vitamin D was estimated. At baseline, all completing participants (n = 51) were vitamin D insufficient [25(OH)D concentrations 10 ng/mL. Targeted guidance on sunlight exposure could usefully enhance vitamin D status to avoid deficiency [25(OH)D concentration >10 ng/mL] in South Asians living at latitudes distant from the equator. This trial was registered at the ISRCTN Register (www.isrctn.org) as 07565297.

  3. Critical heat flux during natural convective boiling in inclined tubes submerged in saturated liquids

    International Nuclear Information System (INIS)

    Liu Zhenhua; Yang Ronghua

    2005-01-01

    An experimental study was carried out to improve and expand understanding of boiling phenomena and the critical heat flux (CHF) during natural convective boiling in uniformly heated inclined tubes submerged in a pool of saturated liquids under atmospheric pressure. The test conditions were as follows: inter diameters of the test tubes ranged from 0.9 to 8.0 mm; heated lengths ranged from 100 to 400 mm, and inclination angles varied from 30 o to vertical position. The test fluids were water and R-11. The experimental results showed that the CHF decreases with the increasing ratio of the tube length to the tube diameter, and with the reducing of the inclination angle. A semi-theoretical correlation, which originally used for the CHF during natural convective boiling in vertical tubes, was modified to predict the CHF occurs in the inclined tubes. The modified correlation agreed reasonably well with the present experimental data and other CHF data for narrow inclined annular tubes

  4. Early changes of cortical blood flow, brain temperature and electrical activity after whole-body irradiation of the monkey (Macaca fascicularis) (dose range: 3-20 Gy)

    International Nuclear Information System (INIS)

    Court, L.; Gourmelon, P.; Mestries, J.C.

    1987-02-01

    A polyparametric investigation was carried out on 31 monkeys chronically wearing bioinstrumentation allowing to get and process simultaneously local brain blood flow, cerebral temperature, and energies in various frequency bands of the brain electrical activity. This method, which supplied data during several consecutive days, made it possible to study both the biological rhythms at the level of the various parameters, and their fast variations. The effects of whole-body gamma or neutron-gamma irradiation were studied in the 3-20 Gy dose range. Immediate changes after exposure demonstrated different radiosensitivities at the level of the rhythms of the various parameters, and/or their recovery, as well as dose-effect relationships [fr

  5. Friction and drag forces on spheres propagating down inclined planes

    Science.gov (United States)

    Tee, Yi Hui; Longmire, Ellen

    2017-11-01

    When a submerged sphere propagates along an inclined wall at terminal velocity, it experiences gravity, drag, lift, and friction forces. In the related equations of motion, the drag, lift and friction coefficients are unknown. Experiments are conducted to determine the friction and drag coefficients of the sphere over a range of Reynolds numbers. Through high speed imaging, translational and rotational velocities of spheres propagating along a glass plate are determined in liquids with several viscosities. The onset of sliding motion is identified by computing the dimensionless rotation rate of the sphere. Using drag and lift coefficients for Re friction coefficients are calculated for several materials. The friction coefficients are then employed to estimate the drag coefficient for 350 frictional force over this Re range. Supported by NSF (CBET-1510154).

  6. Impact of slope inclination on salt accumulation

    Science.gov (United States)

    Nachshon, Uri

    2017-04-01

    Field measurements indicated on high variability in salt accumulation along natural and cultivated slopes, even for relatively homogeneous soil conditions. It was hypothesised that slope inclination has an impact on the location of salt accumulation along the slope. A set of laboratory experiments and numerical models were used to explore the impact of slope inclination on salt accumulation. It was shown, experimentally, that for conditions of saline water source at the lower boundary of the slope - salt accumulates in low concentrations and homogeneously along the entire slope, for moderate slopes. However, as inclination increases high salt concentrations were observed at the upper parts of the slope, leaving the lower parts of the slope relatively free of salt. The traditional flow and transport models did not predict the experimental observations as they indicated also for the moderate slopes on salt accumulation in the elevated parts of the slope, away of the saline water source. Consequently - a conceptual model was raised to explain the laboratory observations. It was suggested that the interactions between slope angle, evaporation rates, hydraulic conductivity of the medium and distribution of wetness along the slope affect the saline water flow path through the medium. This lead to preferential flow path close to the soil-atmosphere interface for the steep slopes, which leads to constant wash of the salts from the evaporation front upward towards the slope upper parts, whereas for the moderate slopes, flow path is below the soil-atmosphere interface, therefore salt that accumulates at the evaporation front is not being transported upward. Understanding of salt dynamics along slopes is important for agricultural and natural environments, as well as for civil engineering purposes. Better understanding of the salt transport processes along slopes will improve our ability to minimize and to cope with soil salinization processes. The laboratory experiments and

  7. Inclined solar chimney for power production

    Energy Technology Data Exchange (ETDEWEB)

    Panse, S.V., E-mail: sudhirpanse@yahoo.com [Institute of Chemical Technology, Matunga, Mumbai 400 019 (India); Jadhav, A.S.; Gudekar, A.S. [Institute of Chemical Technology, Matunga, Mumbai 400 019 (India); Joshi, J.B. [Institute of Chemical Technology, Matunga, Mumbai 400 019 (India); Homi Bhabha National Institute, Trombay, Mumbai 400 094 (India)

    2011-09-15

    Highlights: {yields} Solar energy harnessing using inclined face of high mountains as solar chimney. {yields} Solar chimneys with structural stability, ease of construction and lower cost. {yields} Mathematical model developed, using complete (mechanical and thermal) energy balance. {yields} Can harness wind power also, as wind velocities at mountain top add to power output. {yields} Air temperature and velocity increase, as air rises in inclined chimney. - Abstract: The present concept of solar chimney is a tall vertical chimney constructed at the center of a large area, which is the collector. This creates questions about stability and economic viability of the chimney and also demands elaborate engineering techniques for constructing a tall chimney. We suggest geometry of 'Inclined Solar Chimney' (ISC), which is constructed along the face of a high rising mountain, on which maximum solar insolation is incident throughout the year. The chimney and the collector get merged here. This makes the structure stable, cost effective and easy for construction. A mathematical model has been developed considering the total energy balance. It predicts the temperature and velocity and kinetic power of the emerging air draft for some chosen values of other parameters. The model also shows the proportion in which absorbed solar energy is divided into different forms, and hence predicts the dependence of kinetic of emerging air draft upon dimensions of the chimney and properties of materials used. Further, it is shown that external winds enhance the kinetic power of the emerging air. Thus ISC can also harness the wind energy, available at the top of the mountain.

  8. Velocity and turbulence measurements of oil-water flow in horizontal and slightly inclined pipes using PIV

    OpenAIRE

    Kumara, W.A.S.; Halvorsen, Britt; Melaaen, Morten Christian

    2009-01-01

    Oil-water flows in horizontal and slightly inclined pipes are investigated using Particle Image Velocimetry (PIV). PIV offers a powerful non-invasive tool to study such flow fields. The experiments are conducted in a 15 m long, 56 mm diameter, inclinable steel pipe using Exxsol D60 oil (viscosity 1.64 mPa s, density 790 kg/m3) and water (viscosity 1.0 mPa s, density 996 kg/m3) as test fluids. The test pipe inclination is changed in the range from 5° upward to 5° downward. The experiments are ...

  9. A dose ranging study of the pharmacokinetics, safety, and preliminary efficacy of lamivudine in children and adolescents with chronic hepatitis B.

    Science.gov (United States)

    Sokal, E M; Roberts, E A; Mieli-Vergani, G; McPhillips, P; Johnson, M; Barber, J; Dallow, N; Boxall, E; Kelly, D

    2000-03-01

    Fifty-three patients with chronic hepatitis B and active viral replication were studied for 4 weeks while on treatment and for 12 weeks after treatment with the oral nucleoside analogue lamivudine. Children aged 2 to 12 years were randomized to receive twice-daily doses of 0.35, 1.5, or 4 mg of lamivudine solution per kg of body weight or once-daily doses of 3 mg of lamivudine solution per kg. Adolescents aged 13 to 17 years received lamivudine at 100 mg (as tablets). Blood samples for pharmacokinetic assay were taken on days 1 and 28. Lamivudine was rapidly absorbed following oral administration, with the maximum concentration in serum being reached 0.5 to 1 h postdosing. Apparent oral clearance (CL/F) was higher in younger children and decreased with age, with CL/F values for adolescents reaching those seen for adults by the age of 12. All doses produced a dramatic fall in serum hepatitis B virus (HBV) DNA levels, with a median reduction of >/=99.5% after 4 weeks of treatment and with the levels returning to the baseline levels posttreatment. The correlation of dose, area under the concentration-time curve (AUC), and changes in HBV DNA levels, as measured by the Chiron Quantiplex assay, showed maximal antiviral effects (99.9% inhibition and a reduction of the amount of HBV DNA of approximately 3 log(10)) at 3 mg/kg/day, with no discernible increase in effect seen whether the drug was given at 4 mg/kg twice daily or whether it was given once daily or twice daily. The limit of detection of the assay (2.5 pg/ml) was reached for some but not all patients across the dose ranges, with the smallest number (n = 2) of those having values negative by the Chiron Quantiplex assay being in the lowest-dose group. The 13- to 17-year-olds showed a similar overall response in terms of the HBV DNA level reduction compared to that for patients younger than age 13. Analysis of the same samples by PCR, which has a lower limit of sensitivity than the Chiron Quantiplex assay, also

  10. A Dose Ranging Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of Lamivudine in Children and Adolescents with Chronic Hepatitis B

    Science.gov (United States)

    Sokal, Etienne M.; Roberts, Eve A.; Mieli-Vergani, Giorgina; McPhillips, Penny; Johnson, Mark; Barber, Judy; Dallow, Nigel; Boxall, Elizabeth; Kelly, Deirdre

    2000-01-01

    Fifty-three patients with chronic hepatitis B and active viral replication were studied for 4 weeks while on treatment and for 12 weeks after treatment with the oral nucleoside analogue lamivudine. Children aged 2 to 12 years were randomized to receive twice-daily doses of 0.35, 1.5, or 4 mg of lamivudine solution per kg of body weight or once-daily doses of 3 mg of lamivudine solution per kg. Adolescents aged 13 to 17 years received lamivudine at 100 mg (as tablets). Blood samples for pharmacokinetic assay were taken on days 1 and 28. Lamivudine was rapidly absorbed following oral administration, with the maximum concentration in serum being reached 0.5 to 1 h postdosing. Apparent oral clearance (CL/F) was higher in younger children and decreased with age, with CL/F values for adolescents reaching those seen for adults by the age of 12. All doses produced a dramatic fall in serum hepatitis B virus (HBV) DNA levels, with a median reduction of ≥99.5% after 4 weeks of treatment and with the levels returning to the baseline levels posttreatment. The correlation of dose, area under the concentration-time curve (AUC), and changes in HBV DNA levels, as measured by the Chiron Quantiplex assay, showed maximal antiviral effects (99.9% inhibition and a reduction of the amount of HBV DNA of approximately 3 log10) at 3 mg/kg/day, with no discernible increase in effect seen whether the drug was given at 4 mg/kg twice daily or whether it was given once daily or twice daily. The limit of detection of the assay (2.5 pg/ml) was reached for some but not all patients across the dose ranges, with the smallest number (n = 2) of those having values negative by the Chiron Quantiplex assay being in the lowest-dose group. The 13- to 17-year-olds showed a similar overall response in terms of the HBV DNA level reduction compared to that for patients younger than age 13. Analysis of the same samples by PCR, which has a lower limit of sensitivity than the Chiron Quantiplex assay, also showed

  11. Dense, layered, inclined flows of spheres

    Science.gov (United States)

    Jenkins, James T.; Larcher, Michele

    2017-12-01

    We consider dense, inclined flows of spheres in which the particles translate in layers, whose existence may be promoted by the presence of a rigid base and/or sidewalls. We imagine that in such flows a sphere of a layer is forced up the back of a sphere of the layer below, lifting a column of spheres above it, and then falls down the front of the lower sphere, until it bumps against the preceding sphere of the lower layer. We calculate the forces and rate of momentum transfer associated with this process of rub, lift, fall, and bump and determine a relation between the ratio of shear stress to normal stress and the rate of strain that may be integrated to obtain the velocity profile. The fall of a sphere and that of the column above it results in a linear increase in the magnitude of the velocity fluctuations with distance from the base of the flow. We compare the predictions of the model with measured profiles of velocity and granular temperature in several different dense, inclined flows.

  12. Randomised clinical trial: a dose-ranging study of vonoprazan, a novel potassium-competitive acid blocker, vs. lansoprazole for the treatment of erosive oesophagitis.

    Science.gov (United States)

    Ashida, K; Sakurai, Y; Nishimura, A; Kudou, K; Hiramatsu, N; Umegaki, E; Iwakiri, K; Chiba, T

    2015-09-01

    The potassium-competitive acid blocker vonoprazan (VPZ) has potent acid-inhibitory effects and may offer clinical advantages over conventional therapy for acid-related disorders. To investigate the efficacy and safety of VPZ in patients with erosive oesophagitis (EO). In this multicentre, randomised, double-blind, parallel-group, dose-ranging study, patients ≥20 years with endoscopically confirmed EO [Los Angeles (LA) grades A-D] received VPZ 5, 10, 20 or 40 mg, or lansoprazole (LPZ) 30 mg once daily for 8 weeks. The primary endpoint was the proportion of healed EO subjects as shown by endoscopy at week 4. A total of 732 subjects received VPZ or LPZ. The proportion of healed EO subjects at week 4 was 92.3%, 92.5%, 94.4%, 97.0% and 93.2%, respectively, with VPZ 5, 10, 20 and 40 mg and LPZ 30 mg. All VPZ doses were non-inferior to LPZ when adjusted for baseline LA grades A/B and C/D. Among those with LA grades C/D, the proportions of healed EO subjects were 87.3%, 86.4%, 100%, 96.0% and 87.0%, respectively, with VPZ 5, 10, 20 and 40 mg and LPZ 30 mg. The incidence of adverse events was similar across the groups. Vonoprazan was effective and non-inferior to LPZ in healing EO. VPZ 20 mg or higher was highly efficacious for severe EO (LA grades C/D). VPZ was associated with no safety concern during this 8-week study, while there was a dose-dependent increase in serum gastrin. Once-daily VPZ 20 mg is the recommended clinical dose for treating EO. © 2015 The Authors. Alimentary Pharmacology & Therapeutics published by John Wiley & Sons Ltd.

  13. Constraining the Relative Inclinations of the Planets B and C of the ...

    Indian Academy of Sciences (India)

    of the orbital inclinations iB and iC independently of the pulsar's mass M. It turns out that coplanarity of the orbits of B and C would imply a violation of the equivalence principle. Adopting a pulsar mass range 1 ≲ M ≲ 3, in solar masses (supported by present-day theoretical and observational bounds for pulsar's masses), ...

  14. A Study of Static Performance of Fixed Inclined Slider Bearings – A ...

    African Journals Online (AJOL)

    Michael Horsfall

    and friction. He compared numerical solutions for the bearing performance metrics with analytical solution using a range of bearing aspect ratios and power law indices. In this paper, we present the effect of power law fluids on the static performance characteristics of inclined slider bearings. Based on the power law model ...

  15. Dose-ranging pilot randomized trial of amino acid mixture combined with physical activity promotion for reducing abdominal fat in overweight adults

    Directory of Open Access Journals (Sweden)

    Sasai H

    2017-07-01

    Full Text Available Hiroyuki Sasai,1–3,* Keisuke Ueda,4,5,* Takehiko Tsujimoto,6,7 Hiroyuki Kobayashi,1 Chiaki Sanbongi,4 Shuji Ikegami,4 Yoshio Nakata1 1Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki, 2Japan Society for the Promotion of Science, Chiyoda, Tokyo, 3Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Meguro, Tokyo, 4Food Science Research Laboratories, Meiji Co., Ltd., Odawara, Kanagawa, 5Graduate School of Comprehensive Human Sciences, 6Faculty of Health and Sport Sciences, University of Tsukuba, Tsukuba, Ibaraki, 7Faculty of Human Sciences, Shimane University, Matsue, Shimane, Japan *These authors contributed equally to this work Objective: The objective of this study was to determine the effective dose of an amino acid mixture comprising arginine, alanine, and phenylalanine combined with physical activity promotion in reducing abdominal fat among overweight adults.Methods: A 12-week randomized, double-blind, placebo-controlled, dose-ranging, pilot trial was conducted in Mito, Japan, from January through April 2016, and the data were analyzed from May through November 2016. The study participants were 35 overweight adults, aged 20–64 years, with no regular exercise habit. Participants were randomly assigned to high-dose (3,000 mg/d, n=9, medium-dose (1,500 mg/d, n=9, low-dose (750 mg/d, n=8, or placebo (0 mg/d, n=9 groups, and the test beverage containing the amino acid mixture or placebo was administered for 12 weeks. All participants maintained a physically active lifestyle during the study period through monthly physical activity promotion sessions and smartphone-based self-monitoring with wearable trackers. Primary outcomes were changes in abdominal total, subcutaneous, and visceral fat areas, assessed by computed tomography.Results: Of the 35 enrolled participants, 32 completed the 12-week follow-up visit. The intention-to-treat analysis revealed that the changes in abdominal total fat

  16. Experimental investigation of turbulent flow in a channel with the backward-facing inclined step

    Directory of Open Access Journals (Sweden)

    Uruba Václav

    2012-04-01

    Full Text Available The work deals with the experimental investigation of turbulent flow in a closed channel with the backward-facing inclined step. Experiments were carried by means of the PIV optical measuring method in the channel of the rectangular cross-section in the inlet part and with inclined steps of the constant height H mm and various inclination angles for a wide range of the Reynolds number. The attention was paid especially to the separation region behind the step and to the relaxation of the shear layer after the reattachment in the outlet part of the channel. The dependence of the length of the separation region on the Reynolds number was obtained for various step angles. Optical measurements were completed by the measurement of static pressure distribution in the inlet and outlet part of the channel to estimate energy losses.

  17. Safety, immunogenicity and dose ranging of a new Vi-CRM₁₉₇ conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults.

    Science.gov (United States)

    van Damme, Pierre; Kafeja, Froukje; Anemona, Alessandra; Basile, Venere; Hilbert, Anne Katrin; De Coster, Ilse; Rondini, Simona; Micoli, Francesca; Qasim Khan, Rana M; Marchetti, Elisa; Di Cioccio, Vito; Saul, Allan; Martin, Laura B; Podda, Audino

    2011-01-01

    Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from Asia. Epidemiological data show high disease incidence in young children and suggest that immunization programs should target children below two years of age: this is not possible with available vaccines. The Novartis Vaccines Institute for Global Health developed a conjugate vaccine (Vi-CRM₁₉₇) for infant vaccination concomitantly with EPI vaccines, either starting at 6 weeks with DTP or at 9 months with measles vaccine. We report the results from a Phase 1 and a Phase 2 dose ranging trial with Vi-CRM₁₉₇ in European adults. Following randomized blinded comparison of single vaccination with either Vi-CRM₁₉₇ or licensed polysaccharide vaccines (both containing 25·0 µg of Vi antigen), a randomised observer blinded dose ranging trial was performed in the same center to compare three concentrations of Vi-CRM₁₉₇ (1·25 µg, 5·0 µg and 12·5 µg of Vi antigen) with the polysaccharide vaccine. All vaccines were well tolerated. Compared to the polysaccharide vaccine, Vi-CRM₁₉₇ induced a higher incidence of mild to moderate short lasting local pain. All Vi-CRM₁₉₇ formulations induced higher Vi antibody levels compared to licensed control, with clear dose response relationship. Vi-CRM₁₉₇ did not elicit safety concerns, was highly immunogenic and is therefore suitable for further clinical testing in endemic populations of South Asia. ClinicalTrials.gov NCT01123941 NCT01193907.

  18. Safety, immunogenicity and dose ranging of a new Vi-CRM₁₉₇ conjugate vaccine against typhoid fever: randomized clinical testing in healthy adults.

    Directory of Open Access Journals (Sweden)

    Pierre van Damme

    Full Text Available Typhoid fever causes more than 21 million cases of disease and 200,000 deaths yearly worldwide, with more than 90% of the disease burden being reported from Asia. Epidemiological data show high disease incidence in young children and suggest that immunization programs should target children below two years of age: this is not possible with available vaccines. The Novartis Vaccines Institute for Global Health developed a conjugate vaccine (Vi-CRM₁₉₇ for infant vaccination concomitantly with EPI vaccines, either starting at 6 weeks with DTP or at 9 months with measles vaccine. We report the results from a Phase 1 and a Phase 2 dose ranging trial with Vi-CRM₁₉₇ in European adults.Following randomized blinded comparison of single vaccination with either Vi-CRM₁₉₇ or licensed polysaccharide vaccines (both containing 25·0 µg of Vi antigen, a randomised observer blinded dose ranging trial was performed in the same center to compare three concentrations of Vi-CRM₁₉₇ (1·25 µg, 5·0 µg and 12·5 µg of Vi antigen with the polysaccharide vaccine.All vaccines were well tolerated. Compared to the polysaccharide vaccine, Vi-CRM₁₉₇ induced a higher incidence of mild to moderate short lasting local pain. All Vi-CRM₁₉₇ formulations induced higher Vi antibody levels compared to licensed control, with clear dose response relationship.Vi-CRM₁₉₇ did not elicit safety concerns, was highly immunogenic and is therefore suitable for further clinical testing in endemic populations of South Asia.ClinicalTrials.gov NCT01123941 NCT01193907.

  19. Assessment of In Vivo Efficacy of Eravacycline against Enterobacteriaceae Exhibiting Various Resistance Mechanisms: A Dose-Ranging Study and PK/PD Analysis.

    Science.gov (United States)

    Thabit, Abrar K; Monogue, Marguerite L; Newman, Joseph V; Nicolau, David P

    2018-01-08

    After the pharmacokinetic (PK) profile of eravacycline as a novel fluorocycline was defined, understanding its pharmacodynamic (PD) profile became essential. The aim of this study was to assess the correlation of the PK/PD index of the area under free drug concentration-time curve above the minimum inhibitory concentration (fAUC/MIC) and its magnitude with eravacycline's efficacy against Enterobacteriaceae isolates using the immunocompetent murine thigh infection model to resemble the immunocompetent environment in eravacycline's clinical trials. Eight Enterobacteriaceae isolates with various resistance mechanisms were selected and tested. Eravacycline doses ranged 1-10 mg/kg/day and were given either once daily or divided into q12h doses over the 24h treatment period. Antibacterial efficacy was measured as the change in log 10 CFU at 24h compared with 0h controls. Composite data were modeled using a sigmoid E max model. Eravacycline MICs ranged 0.125-0.5 µg/ml. The mean fAUC/MIC magnitudes required for stasis and 1-log reduction for the eight isolates were 2.9 ± 3.1 and 5.6 ± 5.0, respectively. While the humanized eravacycline regimen (2.5 mg/kg q12h) pharmacokinetically achieves a fAUC 0-24 that is higher than the fAUC 0-24 achieved with the 5 mg/kg q24h dose, the latter was associated with higher efficacy raising a suggestive correlation of the free peak drug concentration to the MIC (fC max /MIC) index with eravacycline's efficacy. This study showed that the magnitudes associated with the efficacy of eravacycline in the immunocompetent murine thigh model appear to be close to achievable targets in human. These data support further development of eravacycline for the treatment of infections caused by drug-resistant Enterobacteriaceae. Copyright © 2018 Elsevier B.V. and International Society of Chemotherapy. All rights reserved.

  20. Granular flow over inclined channels with constrictions

    Science.gov (United States)

    Tunuguntla, Deepak; Weinhart, Thomas; Thornton, Anthony; Bokhove, Onno

    2013-04-01

    Study of granular flows down inclined channels is essential in understanding the dynamics of natural grain flows like landslides and snow avalanches. As a stepping stone, dry granular flow over an inclined channel with a localised constriction is investigated using both continuum methods and particle simulations. Initially, depth-averaged equations of motion (Savage & Hutter 1989) containing an unknown friction law are considered. The shallow-layer model for granular flows is closed with a friction law obtained from particle simulations of steady flows (Weinhart et al. 2012) undertaken in the open source package Mercury DPM (Mercury 2010). The closed two-dimensional (2D) shallow-layer model is then width-averaged to obtain a novel one-dimensional (1D) model which is an extension of the one for water flows through contraction (Akers & Bokhove 2008). Different flow states are predicted by this novel one-dimensional theory. Flow regimes with distinct flow states are determined as a function of upstream channel Froude number, F, and channel width ratio, Bc. The latter being the ratio of the channel exit width and upstream channel width. Existence of multiple steady states is predicted in a certain regime of F - Bc parameter plane which is in agreement with experiments previously undertaken by (Akers & Bokhove 2008) and for granular flows (Vreman et al. 2007). Furthermore, the 1D model is verified by solving the 2D shallow granular equations using an open source discontinuous Galerkin finite element package hpGEM (Pesch et al. 2007). For supercritical flows i.e. F > 1 the 1D asymptotics holds although the two-dimensional oblique granular jumps largely vary across the converging channel. This computationally efficient closed 1D model is validated by comparing it to the computationally more expensiveaa three-dimensional particle simulations. Finally, we aim to present a quasi-steady particle simulation of inclined flow through two rectangular blocks separated by a gap

  1. A dose-ranging study of pramipexole for the symptomatic treatment of restless legs syndrome: polysomnographic evaluation of periodic leg movements and sleep disturbance.

    Science.gov (United States)

    Jama, Leni; Hirvonen, Kari; Partinen, Markku; Alakuijala, Anniina; Hublin, Christer; Tamminen, Ilkka; Koester, Juergen; Reess, Juergen

    2009-06-01

    To evaluate, both polysomnographically and by subjective scales, the efficacy and safety profile of pramipexole for restless legs syndrome (RLS) via a 3-week, double-blind, placebo-controlled, parallel-group, dose-ranging study. At baseline and after 3 weeks, periodic limb movements (PLM) and sleep parameters were assessed by polysomnography, and patients self-assessed their sleep disturbance and overall RLS severity using the international RLS study group rating scale (IRLS). Four pramipexole doses were evaluated: 0.125, 0.25, 0.50, and 0.75mg/d. Data from 107 patients were included in the intent-to-treat (ITT) analysis. For pramipexole recipients, the primary outcome measure, PLM per hour in bed asleep or awake (the PLM index, or PLMI), decreased by a median of -26.55 to -52.70 depending on dosage group, vs. -3.00 for placebo (p<0.01 or 0.001 for each group vs. placebo; Wilcoxon-Mann-Whitney test). Improvements in the secondary endpoints of PLM while asleep and while awake were also significantly superior for pramipexole. At 3 weeks, all pramipexole doses reduced the median for PLM while asleep to levels considered normal (<5PLM/h). Except for delta-sleep time and awakenings/arousals, sleep parameters remained unchanged or favored pramipexole. Median sleep latency was reduced by -5.00 to -11.75min in the pramipexole groups, vs. -2.00 for placebo (p<0.05 for all groups except 0.25mg/d). Median total sleep time increased by 25.75-66.75min, vs. 25.50 (p<0.05 for 0.50mg/d), and median time in stages 2-4/rapid eye movement (REM) sleep increased by 37.00-68.00min, vs. 26.75 (p<0.05 for 0.50mg/d). By subjective IRLS ratings, all pramipexole doses were significantly superior to placebo. Safety analysis demonstrated no dose-dependent increase in adverse events, and no drug-related increase in daytime somnolence was observed. Pramipexole is effective and well tolerated in RLS, most notably among objective measures, for reducing PLM and decreasing sleep latency. Although

  2. A phase 2a randomized, parallel group, dose-ranging study of molindone in children with attention-deficit/hyperactivity disorder and persistent, serious conduct problems.

    Science.gov (United States)

    Stocks, Jennifer Dugan; Taneja, Baldeo K; Baroldi, Paolo; Findling, Robert L

    2012-04-01

    To evaluate safety and tolerability of four doses of immediate-release molindone hydrochloride in children with attention-deficit/hyperactivity disorder (ADHD) and serious conduct problems. This open-label, parallel-group, dose-ranging, multicenter trial randomized children, aged 6-12 years, with ADHD and persistent, serious conduct problems to receive oral molindone thrice daily for 9-12 weeks in four treatment groups: Group 1-10 mg (5 mg if weight conduct problems. Secondary outcome measures included change in Nisonger Child Behavior Rating Form-Typical Intelligence Quotient (NCBRF-TIQ) Conduct Problem subscale scores, change in Clinical Global Impressions-Severity (CGI-S) and -Improvement (CGI-I) subscale scores from baseline to end point, and Swanson, Nolan, and Pelham rating scale-revised (SNAP-IV) ADHD-related subscale scores. The study randomized 78 children; 55 completed the study. Treatment with molindone was generally well tolerated, with no clinically meaningful changes in laboratory or physical examination findings. The most common treatment-related adverse events (AEs) included somnolence (n=9), weight increase (n=8), akathisia (n=4), sedation (n=4), and abdominal pain (n=4). Mean weight increased by 0.54 kg, and mean body mass index by 0.24 kg/m(2). The incidence of AEs and treatment-related AEs increased with increasing dose. NCBRF-TIQ subscale scores improved in all four treatment groups, with 34%, 34%, 32%, and 55% decreases from baseline in groups 1, 2, 3, and 4, respectively. CGI-S and SNAP-IV scores improved over time in all treatment groups, and CGI-I scores improved to the greatest degree in group 4. Molindone at doses of 5-20 mg/day (children weighing <30 kg) and 20-40 mg (≥ 30 kg) was well tolerated, and preliminary efficacy results suggest that molindone produces dose-related behavioral improvements over 9-12 weeks. Additional double-blind, placebo-controlled trials are needed to further investigate molindone in this pediatric population.

  3. Inclined Buildings – Some Reasons and Solutions

    Science.gov (United States)

    Kijanka, Małgorzata; Kowalska, Magdalena

    2017-10-01

    To straighten a leaning building is never easy. There are no standard solutions. On the other hand, there are several, usually historical, leaning structures which have not been rectified, mostly because in the current shape they are a touristic attraction - the best example being the famous Leaning Tower of Pisa. This does not mean however that inclination of load bearing walls can be ignored. Even though in some cases the problem can be treated in terms of serviceability limit states (the deformation is only decreasing the comfort of ‘normal use’ of the building), in the other – it may be a signal of the forthcoming structural failure. The situation must always be treated individually – if the problem concerns a residential building, then cracks on the walls, not-opening doors or tilted ceilings, which often coincide with the leaning of the external walls, are always the reason of worry and such a building needs to be straightened. The reasons of the problem lie usually in uneven settlement of the ground, which in turn, may be caused by various problems, such as the presence of too soft, too weak, unconsolidated or expansive soils under the building, varying groundwater table, mining activity etc. Solving of the problem by just straightening the building is often not enough. To prevent further deformations a detailed analysis of the possible causes is necessary. Sometimes it may be helpful to review similar cases. The paper contains a general overview of selected inclined buildings: starting with the well-known historical examples and ending with individual houses from the Region of Silesia. Since the problem of instability mostly affects structures with critical height to width ratio, tall and narrow structures (towers) are dominating in the work. The aim of the study was to describe the reasons of the problems and present solutions that have been successfully applied and can be also useful to engineers and designers to prevent similar situations.

  4. Impinging Water Droplets on Inclined Glass Surfaces

    Energy Technology Data Exchange (ETDEWEB)

    Armijo, Kenneth Miguel [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lance, Blake [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Ho, Clifford K. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

    2017-09-01

    Multiphase computational models and tests of falling water droplets on inclined glass surfaces were developed to investigate the physics of impingement and potential of these droplets to self-clean glass surfaces for photovoltaic modules and heliostats. A multiphase volume-of-fluid model was developed in ANSYS Fluent to simulate the impinging droplets. The simulations considered different droplet sizes (1 mm and 3 mm), tilt angles (0°, 10°, and 45°), droplet velocities (1 m/s and 3 m/s), and wetting characteristics (wetting=47° contact angle and non-wetting = 93° contact angle). Results showed that the spread factor (maximum droplet diameter during impact divided by the initial droplet diameter) decreased with increasing inclination angle due to the reduced normal force on the surface. The hydrophilic surface yielded greater spread factors than the hydrophobic surface in all cases. With regard to impact forces, the greater surface tilt angles yielded lower normal forces, but higher shear forces. Experiments showed that the experimentally observed spread factor (maximum droplet diameter during impact divided by the initial droplet diameter) was significantly larger than the simulated spread factor. Observed spread factors were on the order of 5 - 6 for droplet velocities of ~3 m/s, whereas the simulated spread factors were on the order of 2. Droplets were observed to be mobile following impact only for the cases with 45° tilt angle, which matched the simulations. An interesting phenomenon that was observed was that shortly after being released from the nozzle, the water droplet oscillated (like a trampoline) due to the "snapback" caused by the surface tension of the water droplet being released from the nozzle. This oscillation impacted the velocity immediately after the release. Future work should evaluate the impact of parameters such as tilt angle and surface wettability on the impact of particle/soiling uptake and removal to investigate ways that

  5. Impact of flow inclination on downwind turbine loads and power

    Science.gov (United States)

    Kress, C.; Chokani, N.; Abhari, R. S.; Hashimoto, T.; Watanabe, M.; Sano, T.; Saeki, M.

    2016-09-01

    Wind turbines frequently operate under situations of pronounced flow inclinations, such as in complex terrain. In the present work the performance and rotor thrust of downwind and upwind turbines in upward and downward flow inclinations are experimentally investigated. In an upward flow inclination of +13°, downwind turbines are shown to have a 29% larger power output than a corresponding upwind turbine, whereas the relative increase in rotor thrust is only 9%. Furthermore, it is also shown that the performance of downwind turbines is less sensitive to changes in the flow inclination, as the upstream nacelle on downwind turbines beneficially redirects and accelerates the flow around the nacelle into the rotor plane.

  6. The Gothic arch (needle point) tracing and condylar inclination.

    Science.gov (United States)

    el-Gheriani, A S; Winstanley, R B

    1987-11-01

    The records of 11 patients referred for treatment of TMJ disorders were used to compare condylar inclination found by drawing a tangent and by using a mathematic technique. Needle point tracing angles were also measured for the same patients and were compared with the condylar inclination. It can be concluded that (1) the mathematic technique outlined records a more accurate condylar angulation, and (2) there is a great variation in condylar inclination values between patients and between left and right sides of the same patient, and (3) there is no direct relationship between condylar inclination and the needle point tracing angle.

  7. Coordinating bracket torque and incisor inclination : Part 3: Validity of bracket torque values in achieving norm inclinations.

    Science.gov (United States)

    Zimmer, Bernd; Sino, Hiba

    2018-03-19

    To analyze common values of bracket torque (Andrews, Roth, MBT, Ricketts) for their validity in achieving incisor inclinations that are considered normal by different cephalometric standards. Using the equations developed in part 1 (eU1 (BOP) = 90° - BT (U1) - TCA (U1) + α 1 - α 2 and eL1 (BOP) = 90° - BT (L1) - TCA (L1) + β 1 - β 2 ) (abbreviations see part 1) and the mean values (± SD) obtained as statistical measures in parts 1 and 2 of the study (α 1 and β 1 [1.7° ± 0.7°], α 2 [3.6° ± 0.3°], β 2 [3.2° ± 0.4°], TCA (U1) [24.6° ± 3.6°] and TCA (L1) [22.9° ± 4.3°]) expected (= theoretically anticipated) values were calculated for upper and lower incisors (U1 and L1) and compared to targeted (= cephalometric norm) values. For U1, there was no overlapping between the ranges of expected and targeted values, as the lowest targeted value of (58.3°; Ricketts) was higher than the highest expected value (56.5°; Andrews) relative to the bisected occlusal plane (BOP). Thus all of these torque systems will aim for flatter inclinations than prescribed by any of the norm values. Depending on target values, the various bracket systems fell short by 1.8-5.5° (Andrews), 6.8-10.5° (Roth), 11.8-15.5° (MBT), or 16.8-20.5° (Ricketts). For L1, there was good agreement of the MBT system with the Ricketts and Björk target values (Δ0.1° and Δ-0.8°, respectively), and both the Roth and Ricketts systems came close to the Bergen target value (both Δ2.3°). Depending on target values, the ranges of deviation for L1 were 6.3-13.2° for Andrews (Class II prescription), 2.3°-9.2° for Roth, -3.7 to -3.2° for MBT, and 2.3-9.2° for Ricketts. Common values of upper incisor bracket torque do not have acceptable validity in achieving normal incisor inclinations. A careful selection of lower bracket torque may provide satisfactory matching with some of the targeted norm values.

  8. LONG-LIVED CHAOTIC ORBITAL EVOLUTION OF EXOPLANETS IN MEAN MOTION RESONANCES WITH MUTUAL INCLINATIONS

    Energy Technology Data Exchange (ETDEWEB)

    Barnes, Rory; Deitrick, Russell; Quinn, Thomas R. [Astronomy Department, University of Washington, Box 951580, Seattle, WA 98195 (United States); Greenberg, Richard [Lunar and Planetary Laboratory, University of Arizona, 1629 E. University Boulevard, Tucson, AZ 86716 (United States); Raymond, Sean N., E-mail: rory@astro.washington.edu [NASA Astrobiology Institute-Virtual Planetary Laboratory Lead Team (United States)

    2015-03-10

    We present N-body simulations of resonant planets with inclined orbits that show chaotically evolving eccentricities and inclinations that can persist for at least 10 Gyr. A wide range of behavior is possible, from fast, low amplitude variations to systems in which eccentricities reach 0.9999 and inclinations 179.°9. While the orbital elements evolve chaotically, at least one resonant argument always librates. We show that the HD 73526, HD 45364, and HD 60532 systems may be in chaotically evolving resonances. Chaotic evolution is apparent in the 2:1, 3:1, and 3:2 resonances, and for planetary masses from lunar- to Jupiter-mass. In some cases, orbital disruption occurs after several gigayears, implying the mechanism is not rigorously stable, just long-lived relative to the main sequence lifetimes of solar-type stars. Planet-planet scattering appears to yield planets in inclined resonances that evolve chaotically in about 0.5% of cases. These results suggest that (1) approximate methods for identifying unstable orbital architectures may have limited applicability, (2) the observed close-in exoplanets may be produced during epochs of high eccentricit induced by inclined resonances, (3) those exoplanets' orbital planes may be misaligned with the host star's spin axis, (4) systems with resonances may be systematically younger than those without, (5) the distribution of period ratios of adjacent planets detected via transit may be skewed due to inclined resonances, and (6) potentially habitable planets may have dramatically different climatic evolution than Earth. The Gaia spacecraft is capable of discovering giant planets in these types of orbits.

  9. Inclined transpression in the Neka Valley, eastern Alborz, Iran

    Science.gov (United States)

    Nabavi, Seyed Tohid; Díaz-Azpiroz, Manuel; Talbot, Christopher J.

    2017-07-01

    Three major nappes in the Neka Valley in the eastern Alborz Mountains of Iran allow the Cimmerian to present convergence following the oblique collision between Iran and the southern margin of Eurasia. This work reports the identification of an inclined transpression zone recognized by field investigations and strain analyses of the geometries of formations and detailed mesoscopic structural analyses of multiple faults, folds and a cleavage. The main structures encountered include refolded recumbent asymmetric fold nappes, highly curved fold hinges, in a transpression zone that dips 37° to the NW between boundaries thrusts striking from N050° to N060°. The β angle (the angle between the zone boundary and direction of horizontal far-field shortening) is about 80°. The north-west and south-east boundaries of this zone coincide with the Haji-abad thrust and the Shah-Kuh thrust, respectively. Fold axes generally trend NE-SW and step to both right and left as a result of strike-slip components of fault displacements. Strain analyses using Fry's method on macroscopic ooids and fusulina deformed into oblate ellipsoids indicate that the natural strain varies between 2.1 and 3.14. The estimated angle between the maximum instantaneous strain axis (ISAmax) and the transpression zone boundary ( θ') is between 6° and 20°. The estimated oblique convergence angle ( α), therefore, ranges between 31° and 43°. The average kinematic vorticity number ( W k ) is 0.6, in a zone of sinistral pure shear-dominated inclined triclinic transpression. These results support the applicability of kinematic models of triclinic transpression to natural brittle-ductile shear zones.

  10. Economic Investigation of Different Configurations of Inclined Solar Water Desalination Systems

    Directory of Open Access Journals (Sweden)

    O. Phillips Agboola

    2014-02-01

    Full Text Available This study empirically investigated the performance of four configurations of inclined solar water desalination (ISWD system for parameters such as daily production, efficiency, system cost, and distilled water production cost. The empirical findings show that in terms of daily productivity improved inclined solar water desalination (IISWD performed best with 6.41 kg/m2/day while improved inclined solar water desalination with wire mesh (IISWDWM produced the least with 3.0 kg/m2/day. In terms of cost price of the systems, the control system inclined solar water desalination (ISWD is the cheapest while IISWDWM is the most expensive system. Distilled water cost price ranges from 0.059 TL/kg, for IISWDW, to 0.134 TL/kg, for IISWDWM system. All the systems are economically and technically feasible as a solar desalination system for potable water in northern Cyprus. Potable water from vendors/hawkers ranges from 0.2 to 0.3 TL/kg.

  11. Entrepreneurial inclinations of women from rural areas

    Directory of Open Access Journals (Sweden)

    Marković-Savić Olivera S.

    2014-01-01

    Full Text Available Entrepreneurial inclinations of women from rural areas are shaped by the lack of business ideas and economic capital, which, in addition to financial resources, includes cultural capital in the form of knowledge and skills. The paper presents a part of a broader study on the social position of women from the rural areas of northern Kosovo and Metohija, conducted in 2013. The research was predominantly focused on entrepreneurial inclinations of rural women, and the findings suggest that private enterprise in the studied population is undeveloped as a result of two dominant reasons. The first reason is the situation which is unfavorable in terms of politics and security, and therefore, not conducive to investment security, together with the specificity in the form of complex administrative business conditions requiring compliance to parallel and mutually incompatible standards (of the Republic of Serbia and of the UNMIK administration. The second important reason for the lack of entrepreneurial initiatives is the lack of ownership of property and the means of production, since banks do not give loans without guarantees in the form of ownership of the mortgage, while other forms of financial incentives are unavailable. The respondents attended programs for acquiring new knowledge and skills only in a small number of cases, while showing the greatest susceptibility to education in traditional skills, such as training in agriculture and handicrafts, which are not the skills in line with the needs of the labor market. As the most important reasons that -prevent them from having their own business, the respondents -mentioned: the lack of ideas and the lack of financial resources. In this regard, they would find incentives in the form of grants most helpful to start their own business. The absence of funds and gender inequality form the basis for the lack of ownership of property and means of production. In addition to the shortage of financial

  12. Self-filtering extremely inclined x-ray crystal monochromator

    Czech Academy of Sciences Publication Activity Database

    Hrdá, Jaromíra; Hrdý, Jaromír

    2011-01-01

    Roč. 44, č. 6 (2011), 1169-1172 ISSN 0021-8898 R&D Projects: GA MPO FR-TI1/412 Institutional research plan: CEZ:AV0Z10100522 Keywords : synchrotron radiation monochromator * x-ray crystal monochromator * inclined monochromator * inclined diffraction Subject RIV: BM - Solid Matter Physics ; Magnetism Impact factor: 5.152, year: 2011

  13. Shallow bias in Mediterranean paleomagnetic directions caused by inclination error

    NARCIS (Netherlands)

    Krijgsman, W.; Tauxe, Lisa

    2004-01-01

    A variety of paleomagnetic data from the Mediterranean region show a strong bias toward shallow inclinations. This pattern of shallow inclinations has been interpreted to be the result of (1) major northward terrane displacement, (2) large nondipole components in the Earth’s magnetic field, and

  14. Analysis of deformation due to inclined load in generalized ...

    African Journals Online (AJOL)

    The present investigation deals with study of deformation in homogeneous, isotropic thermodiffusion elastic half-space as a result of inclined load. The inclined load is assumed to be a linear combination of normal load and tangential load. The integral transform technique is used to solve the problem. As an application of ...

  15. 46 CFR 58.01-40 - Machinery, angles of inclination.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false Machinery, angles of inclination. 58.01-40 Section 58.01-40 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) MARINE ENGINEERING MAIN AND AUXILIARY MACHINERY AND RELATED SYSTEMS General Requirements § 58.01-40 Machinery, angles of inclination. (a) Propulsion machinery and all auxiliary...

  16. Evaluation of a pharmacogenetic-based warfarin dosing algorithm in patients with low time in therapeutic range - study protocol for a randomized controlled trial.

    Science.gov (United States)

    Marcatto, Leiliane Rodrigues; Sacilotto, Luciana; Bueno, Carolina Tosin; Facin, Mirella; Strunz, Celia Maria Cassaro; Darrieux, Francisco Carlos Costa; Scanavacca, Maurício Ibrahim; Krieger, Jose Eduardo; Pereira, Alexandre Costa; Santos, Paulo Caleb Junior Lima

    2016-11-17

    Time in therapeutic range (TTR) is a measurement of quality of warfarin therapy and lower TTR values (algorithm specifically calibrated for a Brazilian patient sample. The aims of this study are: to evaluate the impact of a genetic-based algorithm, compared to traditional anticoagulation, in the time to achieve the therapeutic target and in TTR percentage; and to assess the cost-effectiveness of genotype-guided warfarin dosing in a specific cohort of patients with low TTR (algorithm will be used. At the second, third, fourth and fifth consultations (with an interval of 7 days each) INR will be measured and, if necessary, the dose will be adjusted based on guidelines. Afterwards, patients who are INR stable will begin measuring their INR in 30 day intervals; if the patient's INR is not stable, the patient will return in 7 days for a new measurement of the INR. Outcomes measures will include the time to achieve the therapeutic target and the percentage of TTR at 4 and 12 weeks. In addition, as a secondary end-point, pharmacoeconomic analysis will be carried out. Ethical approval was granted by the Ethics Committee for Medical Research on Human Beings of the Clinical Hospital of the University of São Paulo Medical School. This randomized study will include patients with low TTR and it will evaluate whether a population-specific genetic algorithm might be more effective than traditional anticoagulation for a selected group of poorly anticoagulated patients. ClinicalTrials.gov, NCT02592980 . Registered on 29 October 2015.

  17. Inclined Weight-Loaded Walking at Different Speeds: Pelvis-Shoulder Coordination, Trunk Movements and Cost of Transport.

    Science.gov (United States)

    Rosa, Rodrigo Gomes da; Gomeñuka, Natalia Andrea; Oliveira, Henrique Bianchi de; Peyré-Tartaruga, Leonardo Alexandre

    2018-01-01

    Although studied at level surface, the trunk kinematics and pelvis-shoulder coordination of incline walking are unknown. The aim of this study was to evaluate the speed effects on pelvis-shoulder coordination and trunk movement and the cost of transport (C) during unloaded and loaded (25% of body mass) 15% incline walking. We collected 3-dimensional kinematic and oxygen consumption data from 10 physically active young men. The movements were analyzed in the sagittal plane (inclination and range of trunk motion) and the transverse plane (range of shoulder and pelvic girdle motion and phase difference). The rotational amplitude of the shoulder girdle decreased with load at all speeds, and it was lower at the highest speeds. The rotational amplitude of the pelvic girdle did not change with the different speeds. The phase difference was greater at optimal speed (3 km.hr -1 , at the lowest C) in the loaded and the unloaded conditions. The trunk inclination was greater with load and increased with speed, whereas the range of trunk motion was lower in the loaded condition and decreased with increasing speed. In conclusion, the load decreased the range of girdles and trunk motion, and the pelvis-shoulder coordination seemed to be critical for the incline walking performance.

  18. Hairpin packet structure of a turbulent boundary layer in inclined wall-normal/spanwise planes

    Science.gov (United States)

    Lee, Jae Hwa; Sung, Hyung Jin

    2009-11-01

    Turbulent coherent structures associated with hairpin packet motions have been scrutinized using the instantaneous flow fields obtained from the direct numerical simulation (DNS) of a turbulent boundary layer (TBL). The Reynolds number based on the momentum thickness was varied in the range Reθ=890˜2560. This study focused on the hairpin packet motions in inclined wall-normal/spanwise planes. The hairpin vortex signature associated with the hairpin leg components in the vertical inclined plane consists of a counter-rotating vortex pair, upward and downward motions and a stagnation point induced by the Q2 and Q4 events. These hairpin signatures were observed in the instantaneous flow field, in the two-point correlations and in the conditionally averaged flow fields, respectively. We considered three inclined planes (45^o, 90^o, and 135^o) to investigate the spatial characteristics of the hairpin packet motions in the log and wake regions. The statistical flow fields showed that significantly different flow patterns are induced by the intersections of the three inclined planes with the hairpin packet motions.

  19. Inclined asymmetric librations in exterior resonances

    Science.gov (United States)

    Voyatzis, G.; Tsiganis, K.; Antoniadou, K. I.

    2018-04-01

    Librational motion in Celestial Mechanics is generally associated with the existence of stable resonant configurations and signified by the existence of stable periodic solutions and oscillation of critical (resonant) angles. When such an oscillation takes place around a value different than 0 or π , the libration is called asymmetric. In the context of the planar circular restricted three-body problem, asymmetric librations have been identified for the exterior mean motion resonances (MMRs) 1:2, 1:3, etc., as well as for co-orbital motion (1:1). In exterior MMRs the massless body is the outer one. In this paper, we study asymmetric librations in the three-dimensional space. We employ the computational approach of Markellos (Mon Not R Astron Soc 184:273-281, https://doi.org/10.1093/mnras/184.2.273, 1978) and compute families of asymmetric periodic orbits and their stability. Stable asymmetric periodic orbits are surrounded in phase space by domains of initial conditions which correspond to stable evolution and librating resonant angles. Our computations were focused on the spatial circular restricted three-body model of the Sun-Neptune-TNO system (TNO = trans-Neptunian object). We compare our results with numerical integrations of observed TNOs, which reveal that some of them perform 1:2 resonant, inclined asymmetric librations. For the stable 1:2 TNO librators, we find that their libration seems to be related to the vertically stable planar asymmetric orbits of our model, rather than the three-dimensional ones found in the present study.

  20. Development of locomotion over inclined surfaces in laying hens.

    Science.gov (United States)

    LeBlanc, C; Tobalske, B; Bowley, S; Harlander-Matauschek, A

    2018-03-01

    The purpose of the present study was to evaluate locomotor strategies during development in domestic chickens (Gallus gallus domesticus); we were motivated, in part, by current efforts to improve the design of housing systems for laying hens which aim to reduce injury and over-exertion. Using four strains of laying hens (Lohmann Brown, Lohmann LSL lite, Dekalb White and Hyline Brown) throughout this longitudinal study, we investigated their locomotor style and climbing capacity in relation to the degree (0 to 70°) of incline, age (2 to 36 weeks) and the surface substrate (sandpaper or wire grid). Chicks and adult fowl performed only walking behavior to climb inclines ⩽40° and performed a combination of wing-assisted incline running (WAIR) or aerial ascent on steeper inclines. Fewer birds used their wings to aid their hind limbs when climbing 50° inclines on wire grid surface compared with sandpaper. The steepness of angle achieved during WAIR and the tendency to fly instead of using WAIR increased with increasing age and experience. White-feathered strains performed more wing-associated locomotor behavior compared with brown-feathered strains. A subset of birds was never able to climb incline angles >40° even when using WAIR. Therefore, we suggest that inclines of up to 40° should be provided for hens in three-dimensional housing systems, which are easily negotiated (without wing use) by chicks and adult fowl.

  1. Natural Circulation Characteristics of a Symmetric Loop under Inclined Conditions

    Directory of Open Access Journals (Sweden)

    Xingtuan Yang

    2014-01-01

    Full Text Available Natural circulation is an important process for primary loops of some marine integrated reactors. The reactor works under inclined conditions when severe accidents happen to the ship. In this paper, to investigate the characteristics of natural circulation, experiments were conducted in a symmetric loop under the inclined angle of 0~45°. A CFD model was also set up to predict the behaviors of the loop beyond the experimental scope. Total circulation flow rate decreases with the increase of inclined angle. Meanwhile one circulation is depressed while the other is enhanced, and accordingly the disparity between the branch circulations arises and increases with the increase of inclined angle. Circulation only takes place in one branch circuit at large inclined angle. Also based on the CFD model, the influences of flow resistance distribution and loop configuration on natural circulation are predicted. The numerical results show that to design the loop with the configuration of big altitude difference and small width, it is favorable to reduce the influence of inclination; however too small loop width will cause severe reduction of circulation ability at large angle inclination.

  2. Articular Eminence Inclination in Medieval and Contemporary Croatian Population

    Science.gov (United States)

    Kranjčić, Josip; Šlaus, Mario; Vodanović, Marin; Peršić, Sanja; Vojvodić, Denis

    2016-12-01

    Articular eminence inclination (AEI) of the temporomandibular joint leads the mandible in its movements. Therefore, the aim of the present study was to determine AEI values in medieval (MP) and recent (RP) Croatian population. The study was carried out on two groups of specimens: first group with 30 MP human dry skulls, while the other, serving as control group consisted of 137 dry skulls. The AEI was measured on lateral digital skull images as the angle between the best fi t line drawn along the posterior wall of the articular eminence and the Frankfurt horizontal plane. No statistically significant (p>0.05) differences between the left and right side AEI were found between MP skulls and RP skulls. The mean value of MP AEI was 45.5˚, with a range of 20.9˚-64˚. The mean RP AEI value was steeper (61.99˚), with a range of 30˚-94˚. Difference between the mean MP and RP AEI values was statistically significant (pmedieval time, and consequently different masticatory loads and forces.

  3. Gas-liquid flow splitting in T-junction with inclined lateral arm

    Science.gov (United States)

    Yang, Le-le; Liu, Shuo; Li, Hua; Zhang, Jian; Wu, Ying-xiang; Xu, Jing-yu

    2018-02-01

    This paper studies the gas-liquid flow splitting in T-junction with inclined lateral arm. The separation mechanism of the T-junction is related to the pressure distribution in the T-junction. It is shown that the separation efficiency strongly depends on the inclination angle, when the angle ranges from 0° to 30°, while not so strongly for angles in the range from 30° to 90° Increasing the number of connecting tubes is helpful for the gas-liquid separation, and under the present test conditions, with four connecting tubes, a good separation performance can be achieved. Accordingly, a multi-tube Y-junction separator with four connecting tubes is designed for the experimental investigation. A good agreement between the simulated and measured data shows that there is an optimal split ratio to achieve the best performance for the multi-tube Y-junction separator.

  4. Evaluation of Bearing Capacity of Strip Foundation Subjected to Eccentric Inclined Loads Using Finite Element Method

    Directory of Open Access Journals (Sweden)

    Ahmed Majeed Ali

    2016-08-01

    Full Text Available In real conditions of structures, foundations like retaining walls, industrial machines and platforms in offshore areas are commonly subjected to eccentrically inclined loads. This type of loading significantly affects the overall stability of shallow foundations due to exposing the foundation into two components of loads (horizontal and vertical and consequently reduces the bearing capacity Based on a numerical analysis performed using finite element software (Plaxis 3D Foundation, the behavior of model strip foundation rested on dry sand under the effect of eccentric inclined loads with different embedment ratios (D/B ranging from (0-1 has been explored. The results display that, the bearing capacity of strip foundation is noticeably decreased with the increase of inclination angle (α and eccentricity ratio (e/B. As well as, a reduction factor (RF expression was appointed to measure the degree of decreasing in the bearing capacity when the model footing is subjected to eccentric inclined load. It was observed that, the (RF decreases as the embedment ratio increases. Moreover, the test results also exhibit that, the model footing bearing capacity is reduced by about (69% when the load inclination is varied from (0° to 20° and the model footing is on the surface. While, the rate of decreasing in the bearing capacity was found to be (58%, for both cases of footing when they are at embedment ratios of (0.5 and 1.0. Also, a comparative study was carried out between the present results and previous experimental test results under the same conditions (soil properties and boundary condition. A good agreement was obtained between the predicted bearing capacities for the two related studies.

  5. Effects of inclined star-disk encounter on protoplanetary disk size

    Science.gov (United States)

    Bhandare, Asmita; Breslau, Andreas; Pfalzner, Susanne

    2016-10-01

    Most, if not all, young stars are initially surrounded by protoplanetary disks. Owing to the preferential formation of stars in stellar clusters, the protoplanetary disks around these stars may potentially be affected by the cluster environment. Various works have investigated the influence of stellar fly-bys on disks, although many of them consider only the effects due to parabolic, coplanar encounters often for equal-mass stars, which is only a very special case. We perform numerical simulations to study the fate of protoplanetary disks after the impact of parabolic star-disk encounter for the less investigated case of inclined up to coplanar, retrograde encounters, which is a much more common case. Here, we concentrate on the disk size after such encounters because this limits the size of the potentially forming planetary systems. In addition, with the possibilities that ALMA offers, now a direct comparison to observations is possible. Covering a wide range of periastron distances and mass ratios between the mass of the perturber and central star, we find that despite the prograde, coplanar encounters having the strongest effect on the disk size, inclined and even the least destructive retrograde encounters mostly also have a considerable effect, especially for close periastron passages. Interestingly, we find a nearly linear dependence of the disk size on the orbital inclination for the prograde encounters, but not for the retrograde case. We also determine the final orbital parameters of the particles in the disk such as eccentricities, inclinations, and semi-major axes. Using this information the presented study can be used to describe the fate of disks and also that of planetary systems after inclined encounters.

  6. Aqua/Aura Spring 2017 Inclination Adjust Maneuver Series

    Science.gov (United States)

    Noyes, Thomas; Stezelberger, Shane

    2017-01-01

    This will be presented at the International Earth Science Constellation Mission Operations Working Group meeting June 13-15, 2017 to discuss the AquaAura Spring 2017 Inclination Adjust Maneuver series.

  7. Brilliance and flux reduction in imperfect inclined crystals

    International Nuclear Information System (INIS)

    Lee, W.K.; Blasdell, R.C.; Fernandez, P.B.; Macrander, A.T.; Mills, D.M.

    1996-01-01

    The inclined crystal geometry has been suggested as a method of reducing the surface absorbed power density of high-heat-load monochromators for third-generation synchrotron radiation sources. Computer simulations have shown that if the crystals are perfectly aligned and have no strains then the diffraction properties of a pair of inclined crystals are very similar to a pair of conventional flat crystals with only subtle effects differentiating the two configurations. However, if the crystals are strained, these subtle differences in the behavior of inclined crystals can result in large beam divergences causing brilliance and flux losses. This manuscript elaborates on these issues and estimates potential brilliance and flux losses from strained inclined crystals at the APS

  8. Systems of pillarless working of adjacent, sloped and inclined seams

    Energy Technology Data Exchange (ETDEWEB)

    Batmanov, Yu.K.; Bakhtin, A.F.; Bulavka, E.I.

    1979-01-01

    An analysis is made (advantages and disadvantages) of existing and recommended (pillarless) systems of working adjacent, sloped, and inclined seams. The economic benefits, area and extent of those systems are indicated. 8 references, 4 figures.

  9. Uplift Capacity of Inclined Underreamed Piles Subjected to Vertical Load

    Science.gov (United States)

    Rahman, Md. Akilur; Sengupta, Siddhartha

    2017-12-01

    Many offshore structures are subjected to overturning moments due to wind load, wave pressure, and ship impacts. Inclined (batter) piles are used to support such structures, and to carry the horizontal and vertical loads resulted from the overturning moments. Though studies have been done with inclined piles having no underream bulb, little information is available in the literature about estimating the uplift capacity of inclined underreamed piles. In the present study laboratory experiments have been done with vertically loaded model piles having no underream as well as with one and two underreams. The piles were positioned at angle of inclination of θ = 0°, 10°, 20°, 30° (with vertical); and placed in locally available sand under vertical uplift load. Three different pile stem diameters (D = 20, 25, and 35 mm) were used. The corresponding pile length to stem diameter (l/D) ratio were 18, 14, and 10 respectively. Experiments had been conducted with two relative different densities (45 and 70%) of sand. The failure uplift loads were obtained in each case. It had been found that for inclined piles increase in number of underream bulbs from 0 to 2 was quite effective in resisting uplift loads corresponding to piles having l/D equals to 10. The percentage decreases in uplift capacity corresponding to increase in inclination angle were more pronounced for piles with double underreams.

  10. Trunk muscle activity with different sitting postures and pelvic inclination.

    Science.gov (United States)

    Watanabe, Masahiro; Kaneoka, Koji; Wada, Yusuke; Matsui, Yasushi; Miyakawa, Shumpei

    2014-01-01

    Sitting posture may often place large burden on trunk muscles, while trunk muscle activities in the sitting posture have not been well clarified. In this study, a difference in trunk muscle activity between two kinds of sitting postures was evaluated, focusing on low back pain induced by posture holding. An experiment was conducted on the subjects sitting on a stable-seat and on an unstable-seat, with the pelvis inclined forward, backward, rightward, and leftward. With the pelvis inclined forward, rightward and leftward, muscle activities were significantly increased in a stable-seat sitting posture. In contrast, no significant increase in muscle activity was observed with the pelvis inclined in every direction in an unstable-seat sitting posture. With the pelvis inclined in the stable-seat sitting posture, muscle activities were imbalanced, while with the pelvis inclined in the unstable-seat sitting posture, muscle activities were not imbalanced. Thus, it is suggested that with the pelvis inclined to the maximum extent in the stable-seat sitting posture, low back pain may be induced by imbalanced muscle activities.

  11. Inclination evolution of protoplanetary discs around eccentric binaries

    Science.gov (United States)

    Zanazzi, J. J.; Lai, Dong

    2018-01-01

    It is usually thought that viscous torque works to align a circumbinary disc with the binary's orbital plane. However, recent numerical simulations suggest that the disc may evolve to a configuration perpendicular to the binary orbit ('polar alignment) if the binary is eccentric and the initial disc-binary inclination is sufficiently large. We carry out a theoretical study on the long-term evolution of inclined discs around eccentric binaries, calculating the disc warp profile and dissipative torque acting on the disc. For discs with aspect ratio H/r larger than the viscosity parameter α, bending wave propagation effectively makes the disc precess as a quasi-rigid body, while viscosity acts on the disc warp and twist to drive secular evolution of the disc-binary inclination. We derive a simple analytic criterion (in terms of the binary eccentricity and initial disc orientation) for the disc to evolve towards polar alignment with the eccentric binary. When the disc has a non-negligible angular momentum compared to the binary, the final 'polar alignment' inclination angle is reduced from 90°. For typical protoplanetary disc parameters, the time-scale of the inclination evolution is shorter than the disc lifetime, suggesting that highly inclined discs and planets may exist orbiting eccentric binaries.

  12. Simulation of the effect of incline incident angle in DMD Maskless Lithography

    Science.gov (United States)

    Liang, L. W.; Zhou, J. Y.; Xiang, L. L.; Wang, B.; Wen, K. H.; Lei, L.

    2017-06-01

    The aim of this study is to provide a simulation method for investigation of the intensity fluctuation caused by the inclined incident angle in DMD (digital micromirror device) maskless lithography. The simulation consists of eight main processes involving the simplification of the DMD aperture function and light propagation utilizing the non-parallel angular spectrum method. These processes provide a possibility of co-simulation in the spatial frequency domain, which combines the microlens array and DMD in the maskless lithography system. The simulation provided the spot shape and illumination distribution. These two parameters are crucial in determining the exposure dose in the existing maskless lithography system.

  13. A dose-ranging study to determine the efficacy and safety of 1, 2, and 4mg of dienogest daily for endometriosis.

    Science.gov (United States)

    Köhler, Günter; Faustmann, Thomas A; Gerlinger, Christoph; Seitz, Christian; Mueck, Alfred O

    2010-01-01

    To compare the efficacy and safety of dienogest at doses of 1, 2, and 4mg/day orally in the treatment of endometriosis. An open-label, randomized, multicenter, 24-week comparative trial in women with histologically confirmed endometriosis. Efficacy was assessed by second-look laparoscopy and patient-reported symptoms. Statistical tests included chi(2) and Wilcoxon signed rank tests. Dienogest reduced mean revised American Fertility Society scores from 11.4 to 3.6 (n=29; PDienogest at 2 and 4mg/day was associated with symptom improvements in substantial proportions of women. Both dienogest doses were generally well tolerated, with low rates of treatment discontinuation due to adverse events. The 1-mg dose arm was discontinued owing to insufficient bleeding control. Dienogest at 2mg once a day is recommended as the optimal dose in future studies of endometriosis.

  14. A Phase 1 dose-ranging study examining the effects of a superabsorbent polymer (CLP) on fluid, sodium and potassium excretion in healthy subjects.

    Science.gov (United States)

    Henderson, Lee W; Dittrich, Howard C; Strickland, Alan; Blok, Thomas M; Newman, Richard; Oliphant, Thomas; Albrecht, Detlef

    2014-01-25

    CLP is an orally administered, non-absorbed, superabsorbent polymer being developed to increase fecal excretion of sodium, potassium and water in patients with heart failure and end-stage renal disease. This study was conducted to evaluate the safety of CLP, and to explore dose-related effects on fecal weight, fecal and urine sodium and potassium excretion, and serum electrolyte concentrations. This Phase 1, open-label, dose-escalation study included 25 healthy volunteers, who were administered CLP orally immediately prior to four daily meals for 9 days at doses of 7.5, 15.0, and 25.0 g/day (n = 5/group). An additional dose group received 15.0 g/day CLP under fasting conditions, and an untreated cohort (n = 5) served as control. Twenty-four-hour fecal and urinary output was collected daily. Samples were weighed, and sodium, potassium, and other ion content in stool and urine were measured for each treatment group. Effects on serum cation concentrations, other standard laboratory values, and adverse events were also determined. At doses below 25.0 g/day, CLP was well tolerated, with a low frequency of self-limiting gastrointestinal adverse events. CLP increased fecal weight and fecal sodium and potassium content in a dose-related manner. Concomitant dose-related decreases in urinary sodium and potassium were observed. All serum ion concentrations remained within normal limits. In this study, oral CLP removed water, sodium and potassium from the body via the gastrointestinal tract in a dose related fashion. CLP could become useful for patients with fluid overload and compromised kidney function in conditions such as congestive heart failure, salt sensitive hypertension, chronic kidney disease and end stage renal disease. NCT01944007.

  15. Reconstruction of inclined shower coordinates in electromagnetic calorimeters based on lead glass

    International Nuclear Information System (INIS)

    Vasil'ev, A.N.; Mochalov, V.V.; Solov'ev, L.F.

    2007-01-01

    A method for reconstructing the coordinates of inclined showers in lead glass electromagnetic calorimeters is described. Such showers are generated by photons with energies of 0.5-4.0 GeV that are incident on the detector at angles of as great as 30 deg. An analytical expression for the description of the actual photon coordinate in the calorimeter versus the coordinates of the shower center of gravity is proposed. Using this expression, it is possible to reconstruct the coordinates of inclined electromagnetic showers over wide ranges of angles and energies. The dependences of the spatial resolution on the photon energy and angle are determined. The longitudinal fluctuations of the shower length and their effect on the spatial resolution of the calorimeter are discussed [ru

  16. Sagittal crystal focusing of undulator radiation with high heat load inclined crystals

    International Nuclear Information System (INIS)

    Ice, G.E.; Sparks, C.J.

    1992-01-01

    Sagittal focusing of undulator radiation is shown to be compatible with the proposed inclined double-crystal monochromator geometry for heat load reduction. The focusing aberrations are found to be negligible for typical undulator-beam divergences over a range of magnifications from 1:2 to 6:1 and energies from 3 to 40 keV. The inclined geometry reduces the required signal sagittal curvature of the focusing crystal compared to focusing with conventional symmetric crystals; hence, focusing is possible at higher X-ray energies and with less anticlastic bending. In addition, anticlastic stiffening ribs project a smaller footprint to the beam so that the achievable focal spot size is potentially better than with conventional symmetrically cut crystals. 16 refs

  17. Evaluation of performance of veterinary in-clinic hematology analyzers.

    Science.gov (United States)

    Rishniw, Mark; Pion, Paul D

    2016-12-01

    A previous study provided information regarding the quality of in-clinic veterinary biochemistry testing. However, no similar studies for in-clinic veterinary hematology testing have been conducted. The objective of this study was to assess the quality of hematology testing in veterinary in-clinic laboratories using results obtained from testing 3 levels of canine EDTA blood samples. Clinicians prepared blood samples to achieve measurand concentrations within, below, and above their RIs and evaluated the samples in triplicate using their in-clinic analyzers. Quality was assessed by comparison of calculated total error with quality requirements, determination of sigma metrics, use of a quality goal index, and agreement between in-clinic and reference laboratory instruments. Suitability for statistical quality control was determined using adaptations from the computerized program, EZRules3. Evaluation of 10 veterinary in-clinic hematology analyzers showed that these instruments often fail to meet quality requirements. At least 60% of analyzers reasonably determined RBC, WBC, HCT, and HGB, when assessed by most quality goal criteria; platelets were less reliably measured, with 80% deemed suitable for low platelet counts, but only 30% for high platelet counts, and automated differential leukocyte counts were generally considered unsuitable for clinical use with fewer than 40% of analyzers meeting the least stringent quality goal requirements. Fewer than 50% of analyzers were able to meet requirements for statistical quality control for any measurand. These findings reflect the current status of in-clinic hematology analyzer performance and provide a basis for future evaluations of the quality of veterinary laboratory testing. © 2016 American Society for Veterinary Clinical Pathology.

  18. A photobleaching-based PDT dose metric predicts PDT efficacy over certain BPD concentration ranges in a three-dimensional model of ovarian cancer

    Science.gov (United States)

    Anbil, S.; Rizvi, I.; Celli, J. P.; Alagic, N.; Hasan, T.

    2013-03-01

    Photodynamic therapy (PDT) dosimetry is an active area of study that is motivated by the need to reliably predict treatment outcomes. Implicit dosimetric parameters, such as photosensitizer (PS) photobleaching, may indicate PDT efficacy and could establish a framework to provide patient-customized PDT. Here, tumor destruction and benzoporphryin-derivative (BPD) photobleaching are characterized by systematically varying BPD-light combinations to achieve fixed PDT doses (M * J * cm-2) in a three-dimensional (3D) model of micrometastatic ovarian cancer (OvCa). It is observed that the BPD-light parameters used to construct a given PDT dose significantly impact nodule viability and BPD photobleaching. As a result, PDT dose, when measured by the product of BPD concentration and fluence, does not reliably predict overall efficacy. A PDT dose metric that incorporates a term for BPD photobleaching more robustly predicts PDT efficacy at low concentrations of BPD. These results suggest that PDT dose metrics that are informed by implicit approaches to dosimetry could improve the reliability of PDT-based regimens and provide opportunities for patient-specific treatment planning.

  19. Measurement of the buccolingual inclination of teeth: manual technique vs 3-dimensional software.

    Science.gov (United States)

    Nouri, Mahtab; Abdi, Amir Hossein; Farzan, Arash; Mokhtarpour, Faraneh; Baghban, AliReza Akbarzadeh

    2014-10-01

    In this study, we aimed to measure the inclination of teeth on dental casts by a manual technique with the tooth inclination protractor (TIP; MBI, Newport, United Kingdom) and a newly designed 3-dimensional (3D) software program. The correlation of the 2 techniques was evaluated, and the reliability of each technique was assessed separately. This study was conducted on 36 dental casts of normal, well-aligned Class I occlusions; we assessed 432 teeth. All casts had a normal Class I occlusion. After determining the facial axis of the clinical crown and the facial axis points on the dental casts, we measured the inclinations of the incisors and posterior teeth up to the first molars in each dental arch relative to Andrews' occlusal plane and the posterior occlusal plane using the TIP. Moreover, the casts were scanned by a structured-light 3D scanner. The inclination of teeth relative to the occlusal plane was determined using the new software. To assess the reliability, measurements of all teeth from 15 casts were repeated twice by the 2 methods. Intraclass correlation coefficient and Dahlberg's formula were used for calculation of correlation and reliability. Overall, the 2 techniques were not significantly different in the measurements of the inclinations of the teeth in both jaws. The ranges of Dahlberg's formula were 3.1° to 5.8° for the maxilla and 3.3° to 5.9° for the mandible. The overall correlation of the 2 techniques according to the intraclass correlation coefficient was 0.91. For calculation of reliability, the intraclass correlation coefficients for the TIP and the 3D method were 0.73 and 0.82, respectively. The TIP and the 3D software showed a high correlation for measurement of the inclinations of maxillary and mandibular teeth relative to the occlusal plane. Also, the reproducibility of the measurements in each method was high. Copyright © 2014 American Association of Orthodontists. Published by Elsevier Inc. All rights reserved.

  20. Instability timescale for the inclination instability in the solar system

    Science.gov (United States)

    Zderic, Alexander; Madigan, Ann-Marie; Fleisig, Jacob

    2018-04-01

    The gravitational influence of small bodies is often neglected in the study of solar system dynamics. However, this is not always an appropriate assumption. For example, mutual secular torques between low mass particles on eccentric orbits can result in a self-gravity instability (`inclination instability'; Madigan & McCourt 2016). During the instability, inclinations increase exponentially, eccentricities decrease (detachment), and orbits cluster in argument of perihelion. In the solar system, the orbits of the most distant objects show all three of these characteristics (high inclination: Volk & Malhotra (2017), detachment: Delsanti & Jewitt (2006), and argument of perihelion clustering: Trujillo & Sheppard (2014)). The inclination instability is a natural explanation for these phenomena.Unfortunately, full N-body simulations of the solar system are unfeasible (N ≈ O(1012)), and the behavior of the instability depends on N, prohibiting the direct application of lower N simulations. Here we present the instability timescale's functional dependence on N, allowing us to extrapolate our simulation results to that appropriate for the solar system. We show that ~5 MEarth of small icy bodies in the Sedna region is sufficient for the inclination instability to occur in the outer solar system.

  1. Influence of occlusal plane inclination and mandibular deviation on esthetics.

    Science.gov (United States)

    Corte, Cristiane Cherobini Dalla; Silveira, Bruno Lopes da; Marquezan, Mariana

    2015-10-01

    The aim of this study was to assess the degree of perception of occlusal plane inclination and mandibular deviation in facial esthetics, assessed by laypeople, dentists and orthodontists. A woman with 5.88° of inclination and 5.54 mm of mandibular deviation was selected and, based on her original photograph, four new images were created correcting the deviations and creating more symmetric faces and smiles. Examiners assessed the images by means of a questionnaire. Their opinions were compared by qualitative and quantitative analyses. A total of 45 laypeople, 27 dentists and 31 orthodontists filled out the questionnaires. All groups were able to perceive the asymmetry; however, orthodontists were more sensitive, identifying asymmetries as from 4.32° of occlusal plane inclination and 4.155 mm of mandibular deviation (pocclusal plane inclination and 5.54 mm of mandibular deviation (pOcclusal plane inclination and mandibular deviation were perceived by all groups, but orthodontists presented higher perception of deviations.

  2. Measurements of thermal- and slow-neutron dose distributions in ordinary concrete shield using a reactor neutron beam of different energy ranges

    Energy Technology Data Exchange (ETDEWEB)

    Megahid, R.M.; Makarious, A.S.; El-Kolaly, M.A.; Afifi, Y.A.

    1980-01-01

    Experimental studies on the distribution and attenuation of thermal and slow neutron doses in ordinary concrete shield have been carried-out. A collimated beam of reactor neutrons emitted from one of the horizontal channels of the ET-RR-1 reactor was used. Measurements were performed using, a direct beam, cadmium filtered beam and boron carbide filtered beam. The neutron doses were measured using thermolumin-escent Li/sub 2/B/sub 4/O/sub 7/ detectors. The measured data have been analyzed and a group of attenuation curves were given for beams of reactor neutrons of different energy. These curves show that cadmium and boron carbide filters tend to decrease the neutron doses specially at the beginning of penetration. The data were transformed to that which would be obtained using neutron sources of different geometries.

  3. Pronociceptive and Antinociceptive Effects of Buprenorphine in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude

    Science.gov (United States)

    Gerhold, Katharina J.; Drdla-Schutting, Ruth; Honsek, Silke D.; Forsthuber, Liesbeth

    2015-01-01

    Due to its distinct pharmacological profile and lower incidence of adverse events compared with other opioids, buprenorphine is considered a safe option for pain and substitution therapy. However, despite its wide clinical use, little is known about the synaptic effects of buprenorphine in nociceptive pathways. Here, we demonstrate dose-dependent, bimodal effects of buprenorphine on transmission at C-fiber synapses in rat spinal cord dorsal horn in vivo. At an analgesically active dose of 1500 μg·kg−1, buprenorphine reduced the strength of spinal C-fiber synapses. This depression required activation of spinal opioid receptors, putatively μ1-opioid receptors, as indicated by its sensitivity to spinal naloxone and to the selective μ1-opioid receptor antagonist naloxonazine. In contrast, a 15,000-fold lower dose of buprenorphine (0.1 μg·kg−1), which caused thermal and mechanical hyperalgesia in behaving animals, induced an enhancement of transmission at spinal C-fiber synapses. The ultra-low-dose buprenorphine-induced synaptic facilitation was mediated by supraspinal naloxonazine-insensitive, but CTOP-sensitive μ-opioid receptors, descending serotonergic pathways, and activation of spinal glial cells. Selective inhibition of spinal 5-hydroxytryptamine-2 receptors (5-HT2Rs), putatively located on spinal astrocytes, abolished both the induction of synaptic facilitation and the hyperalgesia elicited by ultra-low-dose buprenorphine. Our study revealed that buprenorphine mediates its modulatory effects on transmission at spinal C-fiber synapses by dose dependently acting on distinct μ-opioid receptor subtypes located at different levels of the neuraxis. PMID:26134641

  4. A Dose Ranging Study of the Pharmacokinetics, Safety, and Preliminary Efficacy of Lamivudine in Children and Adolescents with Chronic Hepatitis B

    OpenAIRE

    Sokal, Etienne M.; Roberts, Eve A.; Mieli-Vergani, Giorgina; McPhillips, Penny; Johnson, Mark; Barber, Judy; Dallow, Nigel; Boxall, Elizabeth; Kelly, Deirdre

    2000-01-01

    Fifty-three patients with chronic hepatitis B and active viral replication were studied for 4 weeks while on treatment and for 12 weeks after treatment with the oral nucleoside analogue lamivudine. Children aged 2 to 12 years were randomized to receive twice-daily doses of 0.35, 1.5, or 4 mg of lamivudine solution per kg of body weight or once-daily doses of 3 mg of lamivudine solution per kg. Adolescents aged 13 to 17 years received lamivudine at 100 mg (as tablets). Blood samples for pharma...

  5. Droplet Depinning on Inclined Surfaces at High Reynolds Numbers

    Science.gov (United States)

    White, Edward; Singh, Natasha; Lee, Sungyon

    2017-11-01

    Contact angle hysteresis enables a sessile liquid drop to adhere to a solid surface when the surface is inclined, the drop is exposed to gas-phase flow, or the drop is exposed to both forcing modalities. Previous work by Schmucker and White (2012.DFD.M4.6) identified critical depinning Weber numbers for water drops subject to gravity- and wind-dominated forcing. This work extends the Schmucker and White data and finds the critical depinning Weber number obeys a two-slope linear model. Under pure wind forcing at Reynolds numbers above 1500 and with zero surface inclination, Wecrit = 8.0 . For non-zero inclinations, α, Wecrit decreases proportionally to A Bo sinα where A is the drop aspect ratio and Bo is its Bond number. The same relationship holds for α behavior. Supported by the National Science Foundation through Grant CBET-1605947.

  6. Natural Frequencies and Mode Shapes of Statically Deformed Inclined Risers

    KAUST Repository

    Alfosail, Feras

    2016-10-15

    We investigate numerically the linear vibrations of inclined risers using the Galerkin approach. The riser is modeled as an Euler-Bernoulli beam accounting for the nonlinear mid-plane stretching and self-weight. After solving for the initial deflection of the riser due to self-weight, we use a Galerkin expansion employing 15 axially loaded beam mode shapes to solve the eigenvalue problem of the riser around the static equilibrium configuration. This yields the riser natural frequencies and corresponding exact mode shapes for various values of inclination angles and tension. The obtained results are validated against a boundary-layer analytical solution and are found to be in good agreement. This constitutes a basis to study the nonlinear forced vibrations of inclined risers.

  7. Rolling and sliding motion of spheres propagating down inclined planes in still water

    Science.gov (United States)

    Tee, Yi Hui; Longmire, Ellen

    2016-11-01

    In modelling the motion of spheres submerged in liquid, gravity, drag, lift, and added mass forces have to be taken into account. For spheres contacting bounding surfaces, friction coefficients due to rolling and sliding increase the complexity of the model. In this study, experiments are conducted to investigate the effects of particle density and diameter on the rolling and sliding motion of spheres. Spherical particles with marked surfaces are released from rest on an inclined glass plate in still water at various inclination angles and allowed to accelerate. A 45° mirror mounted beneath the plate allows simultaneous capture of both longitudinal and spanwise motions of the sphere. Based on sequences obtained by high speed imaging, the translational and rotational velocities are determined. Particle Reynolds numbers at terminal velocity range from 400 to 2500 corresponding with Galileo numbers of 800 to 2800. By comparing the translational and rotational velocities, the occurrence of sliding motion can be identified. The onset of sliding motion is then determined as a function of inclination angle and Galileo number for multiple particle materials. The experimental results are also compared against the existing models from the literature. Supported by NSF (CBET-1510154).

  8. A phase 2, randomized, placebo-controlled, dose-ranging study of the calcium-sensing receptor antagonist MK-5442 in the treatment of postmenopausal women with osteoporosis.

    Science.gov (United States)

    Halse, Johan; Greenspan, Susan; Cosman, Felicia; Ellis, Graham; Santora, Arthur; Leung, Albert; Heyden, Norman; Samanta, Suvajit; Doleckyj, Steven; Rosenberg, Elizabeth; Denker, Andrew E

    2014-11-01

    MK-5442 is an orally bioavailable calcium-sensing receptor antagonist that is hypothesized to stimulate bone formation by stimulating endogenous secretion of a pulse of PTH. Earlier clinical and preclinical studies demonstrated increased bone mineral density (BMD) after treatment. Our objective was to identify a dose of MK-5442 that produces osteoanabolic effects without excessive hypercalcemia. This was a randomized, double-blind, placebo-controlled, parallel-group trial of private or institutional practice. In total, 383 postmenopausal women with osteoporosis were administered daily oral MK-5442 (2.5, 5, 7.5, 10, or 15 mg) or placebo. Serum PTH and calcium, bone turnover markers, areal BMD, and safety were evaluated. A dose-dependent transient increase in PTH occurred after an MK-5442 dose and lasted more than 3.5 hours. Compared with placebo, significant increases in bone formation markers (serum procollagen 1 N-terminal peptide and bone-specific alkaline phosphatase) were observed by 6 months, whereas bone resorption markers (serum C-telopeptide of type 1 collagen, urine N-telopeptides of type 1 collagen) initially decreased but were also significantly increased by 6 months. Despite the biochemical marker changes suggestive of an anabolic response, there were no statistically significant differences between any dose of MK-5442 and placebo in percent change from baseline at month 6 in any of the BMD endpoints. The frequency of hypercalcemia (trough serum calcium ≥ 10.8 mg/dL) was greater with higher MK-5442 doses. In postmenopausal women with low bone mass, treatment with MK-5442 resulted in transient pulses of PTH. Bone formation markers increased quickly and bone resorption markers decreased temporarily, suggestive of an anabolic window. However, there were no increases in BMD versus placebo.

  9. Minimum energy shapes of one-side-pinned static drops on inclined surfaces.

    Science.gov (United States)

    Thampi, Sumesh P; Govindarajan, Rama

    2011-10-01

    The shape that a liquid drop will assume when resting statically on a solid surface inclined to the horizontal is studied here in two dimensions. Earlier experimental and numerical studies yield multiple solutions primarily because of inherent differences in surface characteristics. On a solid surface capable of sustaining any amount of hysteresis, we obtain the global, and hence unique, minimum energy shape as a function of equilibrium contact angle, drop volume, and plate inclination. It is shown, in the energy minimization procedure, how the potential energy of this system is dependent on the basis chosen to measure it from, and two realistic bases, front-pinned and back-pinned, are chosen for consideration. This is at variance with previous numerical investigations where both ends of the contact line are pinned. It is found that the free end always assumes Young's equilibrium angle. Using this, simple equations that describe the angles and the maximum volume are then derived. The range of parameters where static drops are possible is presented. We introduce a detailed force balance for this problem and study the role of the wall in supporting the drop. We show that a portion of the wall reaction can oppose gravity while the other portion aids it. This determines the maximum drop volume that can be supported at a given plate inclination. This maximum volume is the least for a vertical wall, and is higher for all other wall inclinations. This study can be extended to three-dimensional drops in a straightforward manner and, even without this, lends itself to experimental verification of several of its predictions.

  10. Psychopathic Inclination Among Incarcerated Youth of Hazara Division Pakistan

    Directory of Open Access Journals (Sweden)

    Sher Dil

    2016-09-01

    Full Text Available Present study aimed at evaluating the psychopathic inclination among youth and finding the gender differences in psychopathy. An indigenously developed Psychopathy scale (Urdu has been used in this study. Alpha reliability of the scale was .90. The study was conducted on 100 males (50 criminals and 50 non-criminals and 100 females (26 criminals and 74 non-criminals using a convenient sampling technique from three districts of Hazara division: Haripur, Abbottabad, and Mansehra. Results confirmed that there is significant difference in psychopathic inclination of males and females; criminals differed significantly from the non-criminals. The study also paves way for further investigation in the field in Pakistan.

  11. Entrepreneurial Inclination Among Business Students: A Malaysian Study

    Directory of Open Access Journals (Sweden)

    Yet-Mee Lim

    2012-10-01

    Full Text Available Entrepreneurship has been the fundamental topics of discussion among the politicians, economists, and academics. Business creation is especially critical in developing countries to stimulate economic growth. The present study attempts to examine entrepreneurial inclination among students who are a potential source of entrepreneurs. The fi ndings of the present research study indicate that majority of our business students are not entrepreneurial-inclined. They do not seem to possess strong entrepreneurial characteristics and entrepreneurial skills, and they are not keen in starting a new business. The roles of higher institutes of education and the government in promoting entrepreneurship are discussed.

  12. Fluorescence intensity dependence on the propagation plane inclination

    International Nuclear Information System (INIS)

    Fernandez, J.E.; Rubio, Marcelo; Sanchez, H.J.

    1987-01-01

    A Monte Carlo simulation of the primary and secondary X-ray fluorescent emission from an homogeneous and infinite thickness sample, irradiated under different inclination of the propagation plane, is carried out. An agreement with the predictions based on Sherman equations depending on the inclination angle α was found. The invariance of the primary fluorescence with respect to α and the decrease until evanescence of the secondary fluorescence for a α → π/2 are confirmed. A discussion about the physical basis of this dependence is carried out. Similar results are expected for tertiary fluorescence. (Author) [es

  13. Passive dosing of triclosan in multi-generation tests with copepods - Stable exposure concentrations and effects at the low µg l-1 range

    DEFF Research Database (Denmark)

    Ribbenstedt, Anton; Mustajärvi, Lukas; Breitholtz, Magnus

    2017-01-01

    to test the applicability of passive dosing to maintain stable concentrations of the organochlorine bacteriocide triclosan in the water phase during a 6-week multi-generation population development test with the harpacticoid copepod Nitocra spinipes. Triclosan was loaded into silicone (1000 mg), which...... was used as passive dosing phase in the exposure vials. The distribution ratio for triclosan between silicone and water (Dsilicone-water ) was 10466 ± 1927. A population development test was conducted at three concentration levels of triclosan that were measured to be 3-5 µg L(-1) , 7-11 µg L(-1) and 16...... exerted on juvenile development. Progressively lower development index values in the populations exposed to increasing triclosan concentrations suggest developmental retardation. Our results further stress the need for chronic exposure during ecotoxicity testing in chemical risk assessment as even...

  14. Evaluation of the cell death mechanisms activated by the radiopharmaceutical 177Lu-DOTA-anti-CD20 in a dose range of 1 to 5 Gy

    International Nuclear Information System (INIS)

    Azorin V, E.P.; Rojas C, E. L.; Martinez V, B. E.; Ramos B, J. C.; Jimenez M, N. P.; Ferro F, G.

    2016-10-01

    The radio immunotherapy with anti-CD20 antibodies significantly increases the remission rate of patients with B-cell lymphomas over expressing the CD20. The radiolabeled antibodies directed to surface antigens allow delivering scaled doses of radiation to specific targets thus limiting the dose to healthy tissue. The anti-CD20 causes cell death by two major pathways; activating the immune system to destroy malignant cells and inducing the activation of cell death pathways. The 177 Lu is a beta particle emitter (max. 0.497 MeV) with a maximum reach on soft tissue of 0.7 mm and a half-life of 6.7 days. Several clinical studies have established a maximum tolerated dose (45 m Ci/m 2 ) for 177 Lu-DOTA-rituximab, which shows a favorable clinical response without hematological toxicity. However, the molecular mechanisms of action by synergistic effect of anti-CD20 and radionuclide have not been studied. In this work was evaluated; by flow cytometry, the activation kinetics of the cell death mechanisms induced by the treatment with 177 Lu-DOTA-Anti-CD20 in non-Hodgkin (Raji) lymphoma cells. The absorbed radiation dose delivered to the cell nucleus was calculated by Monte Carlo simulation, considering the contribution of the beta emissions of the radiopharmaceutical present in the cell membrane and surrounding environment, as well as crossfire. This work shows that the application of radiation doses of 1 to 5 Gy of the radiopharmaceutical 177 Lu-DOTA-anti-CD20, are sufficient to induce cell death by apoptosis and arrest of the cell cycle. The combination of these factors (continuous delivery of radiation, activation of repair mechanisms and increased radio sensitivity) causes the acute activation of the apoptotic program resulting in significant cell death after 96 h of treatment. The temporal analysis of cell death suggests the early activation of apoptosis that is counteracted by the activation of repair processes caused by sustained irradiation, which leads to cell

  15. Efficacy of adjunctive sertraline for the treatment of HIV-associated cryptococcal meningitis: an open-label dose-ranging study.

    Science.gov (United States)

    Rhein, Joshua; Morawski, Bozena M; Hullsiek, Kathy Huppler; Nabeta, Henry W; Kiggundu, Reuben; Tugume, Lillian; Musubire, Abdu; Akampurira, Andrew; Smith, Kyle D; Alhadab, Ali; Williams, Darlisha A; Abassi, Mahsa; Bahr, Nathan C; Velamakanni, Sruti S; Fisher, James; Nielsen, Kirsten; Meya, David B; Boulware, David R

    2016-07-01

    Cryptococcus is the most common cause of adult meningitis in Africa. We assessed the safety and microbiological efficacy of adjunctive sertraline, previously shown to have in-vitro and in-vivo activity against cryptococcus. In this open-label dose-finding study, we recruited HIV-infected individuals with cryptococcal meningitis who presented to Mulago Hospital in Kampala, Uganda between Aug 14, 2013, and Aug 30, 2014. To assess safety and tolerability, the first 60 participants were given sertraline at escalating doses of 100 mg/day, 200 mg/day, 300 mg/day, or 400 mg/day as induction therapy for 2 weeks, followed by consolidation therapy with 200 mg/day for an additional 8 weeks. From Nov 29, 2013, participants were randomly assigned (1:1) to receive open-label sertraline at predetermined doses of 200 mg/day, 300 mg/day, or 400 mg/day as induction therapy for 2 weeks, followed by consolidation therapy with 200 mg/day for 8 weeks. Dose assignment was made via computer-generated, permuted block randomisation stratified by antiretroviral therapy (ART) status for people with a first episode of meningitis. The primary outcome was 2-week cerebrospinal fluid (CSF) clearance rate of cryptococcus, termed early fungicidal activity, measured in patients with a first episode of culture-positive meningitis and two or more CSF cultures. This study is registered with ClinicalTrials.gov, number NCT01802385. Of the 330 individuals assessed, 172 HIV-infected adults with cryptococcal meningitis were enrolled. We gave 100 mg/day sertraline to 17 patients, 200 mg/day to 12 patients, 300 mg/day to 14 patients, and 400 mg/day to 17 patients. 112 participants were randomly assigned to receive sertraline at 200 mg (n=48), 300 mg (n=36), or 400 mg (n=28) daily for the first 2 weeks, and 200 mg/day thereafter. The final population consisted of 17 participants in the 100 mg group, 60 in the 200 mg group, 50 in the 300 mg group, and 45 in the 400 mg in group. Participants receiving any

  16. Aqua/Aura Inclination Adjust Maneuver Series Spring 2018 Planning

    Science.gov (United States)

    Trenholme, Elena; Boone, Spencer

    2017-01-01

    This will be presented at the International Earth Science Constellation Mission Operations Working Group meeting on December 6-8, 2017 to discuss the Aqua/Aura Spring 2018 Inclination Adjust Maneuver series planning. Presentation has been reviewed and approved by Eric Moyer, ESMO (Earth Science Mission Operations) Deputy Project Manager.

  17. MEASUREMENTS OF DUST EXTINCTION IN HIGHLY INCLINED SPIRAL GALAXIES

    NARCIS (Netherlands)

    JANSEN, RA; KNAPEN, JH; BECKMAN, JE; PELETIER, RF; HES, R

    1994-01-01

    We study the extinction properties of dust in the well-defined dust lanes of four highly inclined galaxies, using U-, B-, V-, R- and I-band CCD and J- and K'-band near-infrared array images. For three of these galaxies, we could use the symmetry of the underlying light profile to obtain absolute

  18. Motion on an Inclined Plane and the Nature of Science

    Science.gov (United States)

    Pendrill, Ann-Marie; Ekström, Peter; Hansson, Lena; Mars, Patrik; Ouattara, Lassana; Ryan, Ulrika

    2014-01-01

    Friction is an important phenomenon in everyday life. All children are familiar with playground slides, which may thus be a good starting point for investigating friction. Motion on an inclined plane is a standard physics example. This paper presents an investigation of friction by a group of 11-year olds. How did they plan their investigations?…

  19. Evidences of inclined transpression at the contact between ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Earth System Science; Volume 125; Issue 5. Evidences of inclined ... a right lateral strike-slip component. As a whole, it is suggested that Udayagiri group is thrusted over Vinjamuru group along a westerly dipping thrust plane with a right lateral strike-slip motion and simultaneous E–W contraction.

  20. Inclined Planes and Motion Detectors: A Study of Acceleration.

    Science.gov (United States)

    Tracy, Dyanne M.

    2001-01-01

    Presents an activity in which students work in cooperative groups and roll balls down inclined planes, collect data with the help of an electronic motion detector, and represent data with a graphing calculator to explore concepts such as mass, gravity, velocity, and acceleration. (Contains 12 references.) (Author/ASK)

  1. The effect of circular bridge piers with different inclination angles ...

    Indian Academy of Sciences (India)

    c Indian Academy of Sciences. The effect of circular bridge piers with different inclination angles toward downstream on scour. MOHAMMAD VAGHEFI1,∗, MASOUD GHODSIAN2 and. SAEID SALIMI3. 1Department of Civil Engineering, Persian Gulf University, Shahid Mahini Street, P.O. Box: 75169-13817,. Bushehr, Iran.

  2. The inter-relationships between angle of inclination, height and ...

    African Journals Online (AJOL)

    Experiments were conducted to investigate the dependence of number of sprouted teak (Tectona grandis Linn. F) stumps on the height above root collar and angle of inclination of planted teak stumps. The studies were aim-ed at developing suitable methods of converting teak seedlings into stumps and planting practices to ...

  3. Reconstruction of Galileo Galilei's Experiment: The Inclined Plane

    Science.gov (United States)

    Straulino, S.

    2008-01-01

    In the "Third Day" of the "Discourses and Mathematical Demonstrations Concerning Two New Sciences" Galileo Galilei describes the famous experiment of the inclined plane and uses it to bring an experimental confirmation to the laws of uniformly accelerated motion. We describe a reconstruction of the experiment and how the results can be used for…

  4. Optimization of PV array inclination in India using ANN estimator ...

    Indian Academy of Sciences (India)

    Home; Journals; Sadhana; Volume 40; Issue 5. Optimization of PV array inclination in India using ANN estimator: Method comparison study ... Although different non-linear, empirical models have been proposed by different researchers in India, they have too many constraints and needs complex and rigorous computational ...

  5. A layered model for inclined pipe flow of settling slurry

    Czech Academy of Sciences Publication Activity Database

    Matoušek, Václav; Krupička, Jan; Kesely, Mikoláš

    2018-01-01

    Roč. 333, June (2018), s. 317-326 ISSN 0032-5910 R&D Projects: GA ČR GA17-14271S Institutional support: RVO:67985874 Keywords : inclined pipe * settling slurry * pressure drop * flow stratification * laboratory loop Impact factor: 2.942, year: 2016

  6. Evidences of inclined transpression at the contact between ...

    Indian Academy of Sciences (India)

    zone may show different structures or dominance of certain type of structures, depending on whether that part is dominated by strike-slip, dip slip or compression. The present study finds evidences of inclined transpression at the contact between. Udayagiri and Vinjamuru group of NSB, which is the main focus of this paper.

  7. Natural convection in inclined hemispherical cavities with isothermal disk and dome faced downwards. Experimental and numerical study

    International Nuclear Information System (INIS)

    Baïri, A.; Monier-Vinard, E.; Laraqi, N.; Baïri, I.; Nguyen, M.N.; Dia, C.T.

    2014-01-01

    The objective of this work is to propose correlations of Nusselt–Rayleigh type for controlling the thermal state of electronic devices used in various engineering sectors such as thermoregulation of electronic devices, solar energy, aeronautics or safety and security. The assemblies are contained in hemispherical air-filled cavities whose disk is maintained isothermal and inclined at an angle varying between 90° (vertical position) and 180° (disk horizontal with isothermal dome oriented downwards). The numerical approach performed by means of the finite volume method for Rayleigh numbers varying between 10 4 and 5 × 10 8 is validated by measurements for various combinations of inclination angle and Rayleigh number. The results of this work show that the natural convective heat transfer are between 13% and 21% higher when the disk is maintained isothermal as compared to the case corresponding to imposed heat flux on the disk, for the same inclination angle and Rayleigh ranges. - Highlights: • Quantification of steady state natural convective heat transfer. • Nu–Ra correlations for large Ra range and Dirichlet-type boundary condition. • Hemispherical air-filled inclined enclosure with dome oriented downwards. • Thermal control of electronic devices for engineering applications. • Experimental and numerical approaches

  8. Passive dosing of triclosan in multigeneration tests with copepods - stable exposure concentrations and effects at the low μg/L range.

    Science.gov (United States)

    Ribbenstedt, Anton; Mustajärvi, Lukas; Breitholtz, Magnus; Gorokhova, Elena; Mayer, Philipp; Sobek, Anna

    2017-05-01

    Ecotoxicity testing is a crucial component of chemical risk assessment. Still, due to methodological difficulties related to controlling exposure concentrations over time, data on long-term effects of organic chemicals at low concentrations are limited. The aim of the present study was, therefore, to test the applicability of passive dosing to maintain stable concentrations of the organochlorine bacteriocide triclosan in the water phase during a 6-wk multigeneration population development test with the harpacticoid copepod Nitocra spinipes. Triclosan was loaded into silicone (1000 mg), which was used as passive dosing phase in the exposure vials. The distribution ratio for triclosan between silicone and water (D silicone-water ) was 10466 ± 1927. A population development test was conducted at 3 concentration levels of triclosan that were measured to be 3 μg/L to 5 μg/L, 7 μg/L to 11 μg/L and 16 μg/L to 26 μg/L. The results demonstrate that passive dosing is applicable for long-term ecotoxicity testing of organic chemicals, including during significant growth of the test organism population. Shifts in the demographic structure of the population during exposure suggest the most severe effects were exerted on juvenile development. Progressively lower development index values in the populations exposed to increasing triclosan concentrations suggest developmental retardation. The results further stress the need for chronic exposure during ecotoxicity testing in chemical risk assessment because even the most sensitive endpoint was not significant until after 7 d of exposure. Environ Toxicol Chem 2017;36:1254-1260. © 2016 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC. © 2016 The Authors. Environmental Toxicology and Chemistry published by Wiley Periodicals, Inc. on behalf of SETAC.

  9. Role of emotional stress in development of somatic breaking beside liquidators of damage on Chernobyl atomic stations, irradiated within the range of small dose

    International Nuclear Information System (INIS)

    Moroz, B.B.; Deshevoj, Yu.B.

    1999-01-01

    On the basis of modern ideas on emotional stress the available data on changes in health states of the Chernobyl accident response participants are considered. The results of psychological, psychophysiological and endocrinological examinations point out to the fact of chronic emotional stress development in great number of the accident response participants. Correlations are supposed to take place between emotional stress and development in accident response participants of the following pathology: mental disorders, cardiovascular pathology, gastric and duodenal ulcer. Problem of combined effects of low dose ionizing radiation and long-term emotional stress on the human organism is studied [ru

  10. Kinematic control of aerodynamic forces on an inclined flapping wing with asymmetric strokes

    International Nuclear Information System (INIS)

    Park, Hyungmin; Choi, Haecheon

    2012-01-01

    In the present study, we conduct an experiment using a one-paired dynamically scaled model of an insect wing, to investigate how asymmetric strokes with different wing kinematic parameters are used to control the aerodynamics of a dragonfly-like inclined flapping wing in still fluid. The kinematic parameters considered are the angles of attack during the mid-downstroke (α md ) and mid-upstroke (α mu ), and the duration (Δτ) and time of initiation (τ p ) of the pitching rotation. The present dragonfly-like inclined flapping wing has the aerodynamic mechanism of unsteady force generation similar to those of other insect wings in a horizontal stroke plane, but the detailed effect of the wing kinematics on the force control is different due to the asymmetric use of the angle of attack during the up- and downstrokes. For example, high α md and low α mu produces larger vertical force with less aerodynamic power, and low α md and high α mu is recommended for horizontal force (thrust) production. The pitching rotation also affects the aerodynamics of a flapping wing, but its dynamic rotational effect is much weaker than the effect from the kinematic change in the angle of attack caused by the pitching rotation. Thus, the influences of the duration and timing of pitching rotation for the present inclined flapping wing are found to be very different from those for a horizontal flapping wing. That is, for the inclined flapping motion, the advanced and delayed rotations produce smaller vertical forces than the symmetric one and the effect of pitching duration is very small. On the other hand, for a specific range of pitching rotation timing, delayed rotation requires less aerodynamic power than the symmetric rotation. As for the horizontal force, delayed rotation with low α md and high α mu is recommended for long-duration flight owing to its high efficiency, and advanced rotation should be employed for hovering flight for nearly zero horizontal force. The present

  11. Kinematic control of aerodynamic forces on an inclined flapping wing with asymmetric strokes.

    Science.gov (United States)

    Park, Hyungmin; Choi, Haecheon

    2012-03-01

    In the present study, we conduct an experiment using a one-paired dynamically scaled model of an insect wing, to investigate how asymmetric strokes with different wing kinematic parameters are used to control the aerodynamics of a dragonfly-like inclined flapping wing in still fluid. The kinematic parameters considered are the angles of attack during the mid-downstroke (α(md)) and mid-upstroke (α(mu)), and the duration (Δτ) and time of initiation (τ(p)) of the pitching rotation. The present dragonfly-like inclined flapping wing has the aerodynamic mechanism of unsteady force generation similar to those of other insect wings in a horizontal stroke plane, but the detailed effect of the wing kinematics on the force control is different due to the asymmetric use of the angle of attack during the up- and downstrokes. For example, high α(md) and low α(mu) produces larger vertical force with less aerodynamic power, and low α(md) and high α(mu) is recommended for horizontal force (thrust) production. The pitching rotation also affects the aerodynamics of a flapping wing, but its dynamic rotational effect is much weaker than the effect from the kinematic change in the angle of attack caused by the pitching rotation. Thus, the influences of the duration and timing of pitching rotation for the present inclined flapping wing are found to be very different from those for a horizontal flapping wing. That is, for the inclined flapping motion, the advanced and delayed rotations produce smaller vertical forces than the symmetric one and the effect of pitching duration is very small. On the other hand, for a specific range of pitching rotation timing, delayed rotation requires less aerodynamic power than the symmetric rotation. As for the horizontal force, delayed rotation with low α(md) and high α(mu) is recommended for long-duration flight owing to its high efficiency, and advanced rotation should be employed for hovering flight for nearly zero horizontal force. The

  12. Pharmacokinetics, tolerability, and preliminary efficacy of paquinimod (ABR-215757), a new quinoline-3-carboxamide derivative: studies in lupus-prone mice and a multicenter, randomized, double-blind, placebo-controlled, repeat-dose, dose-ranging study in patients with systemic lupus erythematosus.

    Science.gov (United States)

    Bengtsson, Anders A; Sturfelt, Gunnar; Lood, Christian; Rönnblom, Lars; van Vollenhoven, Ronald F; Axelsson, Bengt; Sparre, Birgitta; Tuvesson, Helén; Ohman, Marie Wallén; Leanderson, Tomas

    2012-05-01

    To assess the efficacy of paquinimod, a new immunomodulatory small molecule, in a murine lupus model, and to evaluate its pharmacokinetics and tolerability in systemic lupus erythematosus (SLE) patients at doses predicted to be efficacious and safe and determine the maximum tolerated dose. The efficacy of paquinimod was studied in lupus-prone MRL-lpr/lpr mice and compared with that of established SLE treatments. Dose-response data and pharmacokinetic data were used to calculate effective and safe clinical doses of paquinimod. The pharmacokinetics and tolerability of paquinimod were evaluated in a phase Ib double-blind, placebo controlled, dose-ranging study in which cohorts of SLE patients received daily oral treatment for 12 weeks. Paquinimod treatment resulted in disease inhibition in MRL-lpr/lpr mice, comparable to that obtained with prednisolone and mycophenolate mofetil; prominent effects on disease manifestations and serologic markers and a steroid-sparing effect were observed. In patients with SLE, the pharmacokinetic properties of paquinimod were linear and well suitable for once-daily oral treatment. The majority of the adverse events (AEs) were mild or moderate, and transient. The most frequent AEs were arthralgia and myalgia, reported with the highest dose levels of paquinimod (4.5 mg/day and 6.0 mg/day). At the 4.5 mg/day dose level and higher, some AEs of severe intensity and serious adverse events were reported. Paquinimod effectively inhibited disease and had a steroid-sparing effect in experimental lupus. Results from preclinical models together with pharmacokinetic data were successfully translated into a safe clinical dose range, and doses of up to 3.0 mg/day were well tolerated in the SLE patients. Taken together, the promising combined data from a murine model and human SLE support the future clinical development of paquinimod. Copyright © 2012 by the American College of Rheumatology.

  13. A dose-ranging study of the pharmacokinetics and pharmacodynamics of the selective apoptotic antineoplastic drug (SAAND), OSI-461, in patients with advanced cancer, in the fasted and fed state.

    Science.gov (United States)

    O'Bryant, C L; Lieu, C H; Leong, S; Boinpally, R; Basche, M; Gore, L; Leonardi, K; Schultz, M K; Hariharan, S; Chow, L; Diab, S; Gibbs, A; Eckhardt, S G

    2009-02-01

    To evaluate the safety, pharmacokinetics and determine the recommended dose of the selective apoptotic antineoplastic drug, OSI-461 administered on a twice-daily regimen to patients with advanced solid malignancies. In this phase I trial, 33 patients were treated with OSI-461 doses ranging from 400 to 1,200 mg given twice daily in 4-week cycles. Pharmacokinetic studies were performed to characterize the plasma disposition of OSI-461 and the effect of food intake on OSI-461 absorption. Secondary biomarker studies were performed to assess the biologic activity of OSI-461 including the measurement of pGSK-3beta, a PKG substrate, and pharmacogenetic studies to identify polymorphisms of CYP3A that influence drug metabolism and of ABCG2, involved in drug resistance. Thirty-three patients were treated with 86 courses of OSI-461. The dose-limiting toxicities were grade 3 abdominal pain, found in one patient at the 1,000 mg BID fed dose level and all patients at the 1,200 mg BID fed dose level. There was also one episode each of grade 3 fatigue and grade 3 constipation at the 1,000 and 1,200 mg BID fed dose levels, respectively. Other common toxicities included mild to moderate fatigue, nausea, anorexia and mild elevation in bilirubin. Pharmacokinetic studies of OSI-461 revealed approximately a twofold increase in AUC(0-24) when OSI-461 was administered with food. An increase in pGSK-3beta post-dose was seen in the majority of patients and was greater at higher dose levels. No patients exhibited CYP3A4 polymorphisms, while 100% of patients were found to have the CYP3A5*3/CYP3A5*3 polymorphism. Two known polymorphisms of the ABCG2 gene, G34 --> A34 and C421 --> A421, occurred at frequencies of 11.76 and 29%, respectively. Toxicity and pharmacodynamic data show that the recommended oral dose of OSI-461 is 800 mg twice daily administered with food. The drug appears to be well-tolerated, and overall bioavailability appears to be markedly increased when the drug is administered

  14. Egg hatching response to a range of ultraviolet-B (UV-B) radiation doses for four predatory mites and the herbivorous spider mite Tetranychus urticae.

    Science.gov (United States)

    Koveos, Dimitrios S; Suzuki, Takeshi; Terzidou, Anastasia; Kokkari, Anastasia; Floros, George; Damos, Petros; Kouloussis, Nikos A

    2017-01-01

    Egg hatchability of four predatory mites-Phytoseiulus persimilis Athias-Henriot, Iphiseius [Amblyseius] degenerans Berlese, Amblyseius swirskii Athias-Henriot, and Euseius finlandicus Oudemans (Acari: Phytoseiidae)-and the spider mite Tetranychus urticae Koch (Acari: Tetranychidae) was determined under various UV-B doses either in constant darkness (DD) or with simultaneous irradiation using white light. Under UV-B irradiation and DD or simultaneous irradiation with white light, the predator's eggs hatched in significantly lower percentages than in the control non-exposed eggs, which indicates deleterious effects of UV-B on embryonic development. In addition, higher hatchability percentages were observed under UV-B irradiation and DD in eggs of the predatory mites than in eggs of T. urticae. This might be caused by a higher involvement of an antioxidant system, shield effects by pigments or a mere shorter duration of embryonic development in predatory mites than in T. urticae, thus avoiding accumulative effects of UV-B. Although no eggs of T. urticae hatched under UV-B irradiation and DD, variable hatchability percentages were observed under simultaneous irradiation with white light, which suggests the involvement of a photoreactivation system that reduces UV-B damages. Under the same doses with simultaneous irradiation with white light, eggs of T. urticae displayed higher photoreactivation and were more tolerant to UV-B than eggs of the predatory mites. Among predators variation regarding the tolerance to UV-B effects was observed, with eggs of P. persimilis and I. degenerans being more tolerant to UV-B radiation than eggs of A. swirskii and E. finlandicus.

  15. Deontological and utilitarian inclinations in moral decision making: a process dissociation approach.

    Science.gov (United States)

    Conway, Paul; Gawronski, Bertram

    2013-02-01

    Dual-process theories of moral judgment suggest that responses to moral dilemmas are guided by two moral principles: the principle of deontology states that the morality of an action depends on the intrinsic nature of the action (e.g., harming others is wrong regardless of its consequences); the principle of utilitarianism implies that the morality of an action is determined by its consequences (e.g., harming others is acceptable if it increases the well-being of a greater number of people). Despite the proposed independence of the moral inclinations reflecting these principles, previous work has relied on operationalizations in which stronger inclinations of one kind imply weaker inclinations of the other kind. The current research applied Jacoby's (1991) process dissociation procedure to independently quantify the strength of deontological and utilitarian inclinations within individuals. Study 1 confirmed the usefulness of process dissociation for capturing individual differences in deontological and utilitarian inclinations, revealing positive correlations of both inclinations to moral identity. Moreover, deontological inclinations were uniquely related to empathic concern, perspective-taking, and religiosity, whereas utilitarian inclinations were uniquely related to need for cognition. Study 2 demonstrated that cognitive load selectively reduced utilitarian inclinations, with deontological inclinations being unaffected. In Study 3, a manipulation designed to enhance empathy increased deontological inclinations, with utilitarian inclinations being unaffected. These findings provide evidence for the independent contributions of deontological and utilitarian inclinations to moral judgments, resolving many theoretical ambiguities implied by previous research. (c) 2013 APA, all rights reserved.

  16. The lone gamer: Social exclusion predicts violent video game preferences and fuels aggressive inclinations in adolescent players.

    Science.gov (United States)

    Gabbiadini, Alessandro; Riva, Paolo

    2018-03-01

    Violent video game playing has been linked to a wide range of negative outcomes, especially in adolescents. In the present research, we focused on a potential determinant of adolescents' willingness to play violent video games: social exclusion. We also tested whether exclusion can predict increased aggressiveness following violent video game playing. In two experiments, we predicted that exclusion could increase adolescents' preferences for violent video games and interact with violent game playing fostering adolescents' aggressive inclinations. In Study 1, 121 adolescents (aged 10-18 years) were randomly assigned to a manipulation of social exclusion. Then, they evaluated the violent content of nine different video games (violent, nonviolent, or prosocial) and reported their willingness to play each presented video game. The results showed that excluded participants expressed a greater willingness to play violent games than nonviolent or prosocial games. No such effect was found for included participants. In Study 2, both inclusionary status and video game contents were manipulated. After a manipulation of inclusionary status, 113 adolescents (aged 11-16 years) were randomly assigned to play either a violent or a nonviolent video game. Then, they were given an opportunity to express their aggressive inclinations toward the excluders. Results showed that excluded participants who played a violent game displayed the highest level of aggressive inclinations than participants who were assigned to the other experimental conditions. Overall, these findings suggest that exclusion increases preferences for violent games and that the combination of exclusion and violent game playing fuels aggressive inclinations. © 2017 Wiley Periodicals, Inc.

  17. Spectrum of 100-kyr glacial cycle: orbital inclination, not eccentricity.

    Science.gov (United States)

    Muller, R A; MacDonald, G J

    1997-08-05

    Spectral analysis of climate data shows a strong narrow peak with period approximately 100 kyr, attributed by the Milankovitch theory to changes in the eccentricity of the earth's orbit. The narrowness of the peak does suggest an astronomical origin; however the shape of the peak is incompatible with both linear and nonlinear models that attribute the cycle to eccentricity or (equivalently) to the envelope of the precession. In contrast, the orbital inclination parameter gives a good match to both the spectrum and bispectrum of the climate data. Extraterrestrial accretion from meteoroids or interplanetary dust is proposed as a mechanism that could link inclination to climate, and experimental tests are described that could prove or disprove this hypothesis.

  18. Entrepreneurial Inclination Among Business Students: A Malaysian Study

    Directory of Open Access Journals (Sweden)

    Yet-Mee Lim

    2012-11-01

    Full Text Available Normal 0 false false false IN X-NONE AR-SA MicrosoftInternetExplorer4 Entrepreneurship has been the fundamental topics of discussion among the politicians, economists, and academics. Business creation is especially critical in developing countries to stimulate economic growth. The present study attempts to examine entrepreneurial inclination among students who are a potential source of entrepreneurs. The fi ndings of the present research study indicate that majority of our business students are not entrepreneurial-inclined. They do not seem to possess strong entrepreneurial characteristics and entrepreneurial skills, and they are not keen in starting a new business. The roles of higher institutes of education and the government in promoting entrepreneurship are discussed.

  19. Aqua/Aura Updated Inclination Adjust Maneuver Performance Prediction Model

    Science.gov (United States)

    Boone, Spencer

    2017-01-01

    This presentation will discuss the updated Inclination Adjust Maneuver (IAM) performance prediction model that was developed for Aqua and Aura following the 2017 IAM series. This updated model uses statistical regression methods to identify potential long-term trends in maneuver parameters, yielding improved predictions when re-planning past maneuvers. The presentation has been reviewed and approved by Eric Moyer, ESMO Deputy Project Manager.

  20. Graphs and matroids weighted in a bounded incline algebra.

    Science.gov (United States)

    Lu, Ling-Xia; Zhang, Bei

    2014-01-01

    Firstly, for a graph weighted in a bounded incline algebra (or called a dioid), a longest path problem (LPP, for short) is presented, which can be considered the uniform approach to the famous shortest path problem, the widest path problem, and the most reliable path problem. The solutions for LPP and related algorithms are given. Secondly, for a matroid weighted in a linear matroid, the maximum independent set problem is studied.

  1. Determination of angle of inclination for optimum power production ...

    African Journals Online (AJOL)

    This study evaluates the performance of the photovoltaic modules at different tilt angle (angle of inclination) from 5º to 90º. The solar panel of 45 Watts capacity was placed on the manual tracker between the hours of 7:00am and 6:15pm on the geographical location of latitude of 40 55' 58” North and longitude of 60 59' 55” ...

  2. Sagittal x-ray beam deviation at asymmetric inclined diffractors

    Czech Academy of Sciences Publication Activity Database

    Korytár, D.; Hrdý, Jaromír; Artemiev, Nikolai; Ferrari, C.; Freund, A.

    2001-01-01

    Roč. 8, - (2001), s. 1136-1139 ISSN 0909-0495 R&D Projects: GA MŠk OK 305; GA MPO PZ-CH/22 Institutional research plan: CEZ:AV0Z1010914 Keywords : x-ray optics * Si(111) W/grooved crystals * inclined diffraction * out-of-diffraction-plane beams * sagittal focusing Subject RIV: BH - Optics, Masers, Lasers Impact factor: 1.519, year: 2001

  3. The influence of incline walking on joint mechanics.

    Science.gov (United States)

    Haggerty, Mason; Dickin, D Clark; Popp, Jennifer; Wang, Henry

    2014-04-01

    Walking is a popular form of exercise and is associated with many health benefits; however, frontal-plane knee joint loading brought about by a large internal knee-abduction moment and cyclic loading could lead to cartilage degeneration over time. Therefore, knee joint mechanics during an alternative walking exercise needs to be analyzed. The purpose of this study was to examine the lower-extremity joint mechanics in the frontal and sagittal planes during incline walking. Fifteen healthy males walked on a treadmill at five gradients (0%, 5%, 10%, 15%, and 20%) at 1.34m/s, and lower-extremity joint mechanics in the frontal and sagittal planes were quantified. The peak internal knee-abduction moment significantly decreased from the level walking condition at all gradients except 5%. Also, a negative relationship between the internal knee-abduction moment and the treadmill gradient was found to exist in 10% increments (0-10%, 5-15%, and 10-20%). The decrease in the internal knee-abduction moment during incline walking could have positive effects on knee joint health such as potentially reducing cartilage degeneration of the knee joint, reducing pain, and decreasing the rate of development of medial tibiofemoral osteoarthritis. This would be beneficial for a knee surgery patient, obese persons, and older adults who are using incline walking for rehabilitation and exercise protocols. Findings from the current study can provide guidance for the development of rehabilitation and exercise prescriptions incorporating incline walking. Copyright © 2014 Elsevier B.V. All rights reserved.

  4. Three-dimensional volumetric display by inclined-plane scanning

    Science.gov (United States)

    Miyazaki, Daisuke; Eto, Takuma; Nishimura, Yasuhiro; Matsushita, Kenji

    2003-05-01

    A volumetric display system based on three-dimensional (3-D) scanning that uses an inclined two-dimensional (2-D) image is described. In the volumetric display system a 2-D display unit is placed obliquely in an imaging system into which a rotating mirror is inserted. When the mirror is rotated, the inclined 2-D image is moved laterally. A locus of the moving image can be observed by persistence of vision as a result of the high-speed rotation of the mirror. Inclined cross-sectional images of an object are displayed on the display unit in accordance with the position of the image plane to observe a 3-D image of the object by persistence of vision. Three-dimensional images formed by this display system satisfy all the criteria for stereoscopic vision. We constructed the volumetric display systems using a galvanometer mirror and a vector-scan display unit. In addition, we constructed a real-time 3-D measurement system based on a light section method. Measured 3-D images can be reconstructed in the 3-D display system in real time.

  5. Inclined Fiber Pullout from a Cementitious Matrix: A Numerical Study

    Directory of Open Access Journals (Sweden)

    Hui Zhang

    2016-09-01

    Full Text Available It is well known that fibers improve the performance of cementitious composites by acting as bridging ligaments in cracks. Such bridging behavior is often studied through fiber pullout tests. The relation between the pullout force vs. slip end displacement is characteristic of the fiber-matrix interface. However, such a relation varies significantly with the fiber inclination angle. In the current work, we establish a numerical model to simulate the entire pullout process by explicitly representing the fiber, matrix and the interface for arbitrary fiber orientations. Cohesive elements endorsed with mixed-mode fracture capacities are implemented to represent the bond-slip behavior at the interface. Contact elements with Coulomb’s friction are placed at the interface to simulate frictional contact. The bond-slip behavior is first calibrated through pull-out curves for fibers aligned with the loading direction, then validated against experimental results for steel fibers oriented at 30 ∘ and 60 ∘ . Parametric studies are then performed to explore the influences of both material properties (fiber yield strength, matrix tensile strength, interfacial bond and geometric factors (fiber diameter, embedment length and inclination angle on the overall pullout behavior, in particular on the maximum pullout load. The proposed methodology provides the necessary pull-out curves for a fiber oriented at a given angle for multi-scale models to study fracture in fiber-reinforced cementitious materials. The novelty lies in its capacity to capture the entire pullout process for a fiber with an arbitrary inclination angle.

  6. Particle acceleration in relativistic magnetized collisionless pair shocks: a survey of magnetic inclination angles

    Science.gov (United States)

    Sironi, Lorenzo

    We investigate particle acceleration in relativistic magnetized collisionless pair shocks with two-dimensional particle-in-cell numerical simulations. For fixed upstream bulk Lorentz factor γ0 = 15 and magnetic to kinetic energy fraction σ = 0.1, we explore a range of inclination angles θ between the magnetic field and the shock normal. The inclination is measured in the downstream rest frame and the magnetic field lies in a plane perpendicular to the simulation plane. The downstream energy spectrum for subluminal shocks consists of a relativistic Maxwellian and a high-energy power-law tail modified by an exponential cutoff. For parallel shocks (θ = 0° ), the tail accounts for ˜ 1% of the downstream particle number and ˜ 5% of the energy, and its energy spectral index is -2.7 ± 0.1. Accelerated particles bounce between the upstream and the downstream, and the upstream scattering is provided by oblique filaments, which have both an electromagnetic and an electrostatic component. Such filaments propagate towards the shock and are generated by the accelerated particles that escape upstream. For larger inclination angles the acceleration efficiency increases, and particles are efficiently boosted by the motional upstream electric field when gyrating across the shock. Close to the superluminality threshold θ ≈ 30° , the number and energy fractions of downstream accelerated particles are ˜ 3% and ˜ 12% respectively; the spectral index of the corresponding power-law tail is -2.4 ± 0.1. When the shock becomes superluminal (θ 30° ), the acceleration efficiency abruptly drops. Our results show that the range of upstream-frame inclination angles suitable for efficient acceleration in relativistic magnetized pair shocks is indeed very small 30° /γ0 , as suggested by previous Monte-Carlo simulations. Self-generated shock turbulence is shown to be not large enough to overcome the kinematic constraints for superluminal shocks. These findings place constraints

  7. Efficacy and safety of belimumab in patients with rheumatoid arthritis: a phase II, randomized, double-blind, placebo-controlled, dose-ranging Study.

    Science.gov (United States)

    Stohl, William; Merrill, Joan T; McKay, James D; Lisse, Jeffrey R; Zhong, Z John; Freimuth, William W; Genovese, Mark C

    2013-05-01

    To evaluate the efficacy/safety of belimumab in patients with rheumatoid arthritis (RA). Patients fulfilling American College of Rheumatology (ACR) criteria for RA for ≥ 1 year who had at least moderate disease activity while receiving stable disease-modifying antirheumatic drug (DMARD) therapy and failed ≥ 1 DMARD were randomly assigned to placebo or belimumab 1, 4, or 10 mg/kg, administered intravenously on Days 1, 14, and 28, and then every 4 weeks for 24 weeks (n = 283). This was followed by an optional 24-week extension (n = 237) in which all patients received belimumab. Primary efficacy endpoint was the Week 24 ACR20 response. Week 24 ACR20 responses with placebo and belimumab 1, 4, and 10 mg/kg were 15.9%, 34.7% (p = 0.010), 25.4% (p = 0.168), and 28.2% (p = 0.080), respectively. Patients taking any belimumab dose who continued with belimumab in the open-label extension had an ACR20 response of 41% at 48 weeks. A similar ACR20 response (42%) at 48 weeks was seen in patients taking placebo who switched in the extension to belimumab 10 mg/kg. Greater response rates were observed in patients who at baseline were rheumatoid factor-positive, anticitrullinated protein antibody-positive, or tumor necrosis factor inhibitor-naive, or had elevated C-reactive protein levels, Disease Activity Score 28 > 5.1, or low B lymphocyte stimulator levels (< 0.858 ng/ml). Adverse event rates were similar across treatment groups. In this phase II trial, belimumab demonstrated efficacy and was generally well tolerated in patients with RA who had failed previous therapies. [ClinicalTrials.gov identifier NCT00071812].

  8. Effect of a single-session meditation training to reduce stress and improve quality of life among health care professionals: a "dose-ranging" feasibility study.

    Science.gov (United States)

    Prasad, Kavita; Wahner-Roedler, Dietlind L; Cha, Stephen S; Sood, Amit

    2011-01-01

    The primary aim of the study was to assess the feasibility of incorporating a single-session meditation-training program into the daily activities of healthy employees of a tertiary-care academic medical center. The study also assessed the most preferred duration of meditation and the effect of the meditation program on perceived stress, anxiety, and overall quality of life (QOL). Seventeen healthy clinic employees were recruited for this study. After an initial group instruction session covering basic information about meditation, Paced Breathing Meditation (PBM) was taught to the participants. Participants were instructed to self-practice meditation with the help of a DVD daily for a total of 4 weeks. The DVD had three different programs of 5, 15, and 30 minutes with a menu option to choose one of the programs. (1) Patient diary, (2) Perceived Stress Scale (PSS), (3) Linear Analogue Self-Assessment (LASA), (4) Smith Anxiety Scale (SAS). Primary outcome measures were compared using the paired t-test. All participants were female; median age was 48 years (range 33-60 y). The 5-minute meditation session was practiced by 14 participants a total of 137 times during the 4-week trial period, the 15-minute session by 16 participants a total of 223 times, and the 30-minute session by 13 participants 71 times. The median number of days practiced was 25 (range 10-28 d); the average total time practiced was 394 minutes (range 55-850 min). After 4 weeks of practice, the scores of the following instruments improved significantly from baseline: PSS (P meditation in a single training session to health care employees. The study shows that 15 minutes once or twice a day is the most feasible duration of meditation practice. The study also provides promising preliminary efficacy data of this program for improving stress, anxiety, and QOL.

  9. Continuous inclination record of the geomagnetic field from a Brazilian stalagmite

    Science.gov (United States)

    Jaqueto, P.; Trindade, R. I.; Hartmann, G. A.; Feinberg, J. M.; Novello, V. F.; Cruz, F. W.

    2013-12-01

    It is known that South America contributes with less than ~3% of the global database and some of these data (obtained decades ago) do not obey minimum quality criteria, such as standard deviations and age controls. In this sense, continuous full-vector records (direction and intensity) provide important high-resolution data on the spatial and temporal behavior of Earth's magnetic field of utmost importance to describe the evolution of major field features, such as the South Atlantic Magnetic Anomaly (SAMA). Here, we present results of magnetic inclination determined from a stalagmite collected in Pau d'Alho cave located at 14.8° S, 56.4° W (Mato Grosso, Brazil), where no previous geomagnetic record was available. The sample is a 23-cm-long stalagmite which grew continuously during most of the last 1400 years. The chronology based on high-quality U-Th dating ranges from 500 AD to 1900 AD and reveals a nearly constant growth rate of ~150 μm/yr. Remanence measurements of the stalagmite were performed continuously using a SQUID magnetometer with a spatial resolution of 0.5 cm. Magnetic values for each measured point were deconvolved using the singular value decomposition (SVD) method. Hysteresis and low-temperature magnetization analyses indicate a very homogeneous magnetic mineralogy with the presence of tiny concentrations of pure magnetite in the SD-PSD state. After stepwise alternating field demagnetization, inclination data show maximum angular deviation (MAD) for most samples below 5° (with anomalous MAD of up to 15° for the 1660 AD to 1690 AD period). In general, our magnetic inclination data are consistent with those predicted by geomagnetic field models, and will provide a firm observational anchor for future modeling efforts. In this way, continuous magnetic measurements on speleothems can provide important, high-quality information about the short term behavior of the geomagnetic field.

  10. A phase II, randomized, double-blind, placebo-controlled, dose-ranging study of belimumab in patients with active systemic lupus erythematosus.

    Science.gov (United States)

    Wallace, Daniel J; Stohl, William; Furie, Richard A; Lisse, Jeffrey R; McKay, James D; Merrill, Joan T; Petri, Michelle A; Ginzler, Ellen M; Chatham, W Winn; McCune, W Joseph; Fernandez, Vivian; Chevrier, Marc R; Zhong, Z John; Freimuth, William W

    2009-09-15

    To assess the safety, tolerability, biologic activity, and efficacy of belimumab in combination with standard of care therapy (SOC) in patients with active systemic lupus erythematosus (SLE). Patients with a Safety of Estrogens in Lupus Erythematosus: National Assessment (SELENA) version of the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score >/=4 (n = 449) were randomly assigned to belimumab (1, 4, or 10 mg/kg) or placebo in a 52-week study. Coprimary end points were the percent change in the SELENA-SLEDAI score at week 24 and the time to first SLE flare. Significant differences between the treatment and placebo groups were not attained for either primary end point, and no dose response was observed. Reductions in SELENA-SLEDAI scores from baseline were 19.5% in the combined belimumab group versus 17.2% in the placebo group. The median time to first SLE flare was 67 days in the combined belimumab group versus 83 days in the placebo group. However, the median time to first SLE flare during weeks 24-52 was significantly longer with belimumab treatment (154 versus 108 days; P = 0.0361). In the subgroup (71.5%) of serologically active patients (antinuclear antibody titer >/=1:80 and/or anti-double-stranded DNA [anti-dsDNA] >/=30 IU/ml), belimumab treatment resulted in significantly better responses at week 52 than placebo for SELENA-SLEDAI score (-28.8% versus -14.2%; P = 0.0435), physician's global assessment (-32.7% versus -10.7%; P = 0.0011), and Short Form 36 physical component score (+3.0 versus +1.2 points; P = 0.0410). Treatment with belimumab resulted in a 63-71% reduction of naive, activated, and plasmacytoid CD20+ B cells, and a 29.4% reduction in anti-dsDNA titers (P = 0.0017) by week 52. The rates of adverse events and serious adverse events were similar in the belimumab and placebo groups. Belimumab was biologically active and well tolerated. The effect of belimumab on the reduction of SLE disease activity or flares was not significant

  11. GAPS IN PROTOPLANETARY DISKS AS SIGNATURES OF PLANETS. II. INCLINED DISKS

    Energy Technology Data Exchange (ETDEWEB)

    Jang-Condell, Hannah [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Turner, Neal J. [Jet Propulsion Laboratory, California Institute of Technology, Pasadena, CA 91109 (United States)

    2013-07-20

    We examine the observational appearance of partial gaps being opened by planets in protoplanetary disks, considering the effects of the inclination relative to the line of sight. We model the disks with static {alpha}-models with detailed radiative transfer, parameterizing the shape and size of the partially cleared gaps based on the results of hydrodynamic simulations. As in previous work, starlight falling across the gap leads to high surface brightness contrasts. The gap's trough is darkened by both shadowing and cooling, relative to the uninterrupted disk. The gap's outer wall is brightened by direct illumination and also by heating, which puffs it up so that it intercepts more starlight. In this paper, we examine the effects of inclination on resolved images of disks with and without gaps at a wide range of wavelengths. The scattering surface's offset from the disk midplane creates a brightness asymmetry along the axis of inclination, making the disk's near side appear brighter than the far side in scattered light. Finite disk thickness also causes the projected distances of equidistant points on the disk surface to be smaller on the near side of the disk as compared to the far side. Consequently, the gap shoulder on the near side of the disk should appear brighter and closer to the star than on the far side. However, if the angular resolution of the observation is coarser than the width of the brightened gap shoulder, then the gap shoulder on the far side may appear brighter because of its larger apparent size. We present a formula to recover the scale height and inclination angle of an imaged disk using simple geometric arguments and measuring disk asymmetries. Resolved images of circumstellar disks have revealed clearings and gaps, such as the transitional disk in LkCa 15. Models created using our synthetic imaging attempting to match the morphology of observed scattered light images of LkCa 15 indicate that the H-band flux deficit in

  12. Sex Differences in Incline-Walking among Humans.

    Science.gov (United States)

    Wall-Scheffler, Cara M

    2015-12-01

    Previous research has shown that people tend to walk around the speed that minimizes energy consumption when traveling a given distance. It has further been shown that men and women have different speeds that minimize energy and that women will choose slower speeds when the activity itself is a high-rate activity (e.g. carrying a load). Here we investigate what men and women will do when given a high rate walking activity, namely walking on an inclined surface. Fourteen people (nine men and five women) walked at four speeds on a level treadmill and four speeds on an inclined treadmill while their metabolic rate, kinematics and core temperature were monitored. Following the data collection, participants were asked to identify their ‘preferred’ walking speed at each of the conditions. Cost of transport (CoT) curves were calculated for each individual, and the delta between the preferred and the ‘optimal’ speeds were calculated. People chose to walk at slightly slower speeds on the level; there was minimal change in the cost to walk at these slower speeds. Women walked at absolutely slower speeds on the incline than men (P=0.06) and had significantly larger speed deltas (P=0.02), thus choosing to walk at slower rate speeds. Women also showed a significant relationship between the rate of activity and core temperature, whereas men did not. This is consistent with other research showing that women choose behavioral strategies to minimize body temperature changes. © The Author 2015. Published by Oxford University Press on behalf of the Society for Integrative and Comparative Biology. All rights reserved. For permissions please email: journals.permissions@oup.com.

  13. Flame spread over inclined electrical wires with AC electric fields

    KAUST Repository

    Lim, Seung J.

    2017-07-21

    Flame spread over polyethylene-insulated electrical wires was studied experimentally with applied alternating current (AC) by varying the inclination angle (θ), applied voltage (VAC), and frequency (fAC). For the baseline case with no electric field applied, the flame spread rate and the flame width of downwardly spreading flames (DSFs) decreased from the horizontal case for −20° ≤ θ < 0° and maintained near constant values for −90° ≤ θ < −20°, while the flame spread rate increased appreciably as the inclination angle of upwardly spreading flames (USFs) increased. When an AC electric field was applied, the behavior of flame spread rate in DSFs (USFs) could be classified into two (three) sub-regimes characterized by various functional dependences on VAC, fAC, and θ. In nearly all cases of DSFs, a globular molten polyethylene formed ahead of the spreading flame edge, occasionally dripping onto the ground. In these cases, an effective flame spread rate was defined to represent the burning rate by measuring the mass loss due to dripping. This effective spread rate was independent of AC frequency, while it decreased linearly with voltage and was independent of the inclination angle. In DSFs, when excessively high voltage and frequency were applied, the dripping led to flame extinction during propagation and the extinction frequency correlated well with applied voltage. In USFs, when high voltage and frequency were applied, multiple globular molten PEs formed at several locations, leading to ejections of multiple small flame segments from the main flame, thereby reducing the flame spread rate, which could be attributed to the electrospray phenomenon.

  14. Slip resistance of winter footwear on snow and ice measured using maximum achievable incline.

    Science.gov (United States)

    Hsu, Jennifer; Shaw, Robert; Novak, Alison; Li, Yue; Ormerod, Marcus; Newton, Rita; Dutta, Tilak; Fernie, Geoff

    2016-05-01

    Protective footwear is necessary for preventing injurious slips and falls in winter conditions. Valid methods for assessing footwear slip resistance on winter surfaces are needed in order to evaluate footwear and outsole designs. The purpose of this study was to utilise a method of testing winter footwear that was ecologically valid in terms of involving actual human testers walking on realistic winter surfaces to produce objective measures of slip resistance. During the experiment, eight participants tested six styles of footwear on wet ice, on dry ice, and on dry ice after walking over soft snow. Slip resistance was measured by determining the maximum incline angles participants were able to walk up and down in each footwear-surface combination. The results indicated that testing on a variety of surfaces is necessary for establishing winter footwear performance and that standard mechanical bench tests for footwear slip resistance do not adequately reflect actual performance. Practitioner Summary: Existing standardised methods for measuring footwear slip resistance lack validation on winter surfaces. By determining the maximum inclines participants could walk up and down slopes of wet ice, dry ice, and ice with snow, in a range of footwear, an ecologically valid test for measuring winter footwear performance was established.

  15. Mixed convection in inclined lid driven cavity by Lattice Boltzmann Method and heat flux boundary condition

    International Nuclear Information System (INIS)

    D'Orazio, A; Karimipour, A; Nezhad, A H; Shirani, E

    2014-01-01

    Laminar mixed convective heat transfer in two-dimensional rectangular inclined driven cavity is studied numerically by means of a double population thermal Lattice Boltzmann method. Through the top moving lid the heat flux enters the cavity whereas it leaves the system through the bottom wall; side walls are adiabatic. The counter-slip internal energy density boundary condition, able to simulate an imposed non zero heat flux at the wall, is applied, in order to demonstrate that it can be effectively used to simulate heat transfer phenomena also in case of moving walls. Results are analyzed over a range of the Richardson numbers and tilting angles of the enclosure, encompassing the dominating forced convection, mixed convection, and dominating natural convection flow regimes. As expected, heat transfer rate increases as increases the inclination angle, but this effect is significant for higher Richardson numbers, when buoyancy forces dominate the problem; for horizontal cavity, average Nusselt number decreases with the increase of Richardson number because of the stratified field configuration

  16. Motion of phospholipidic vesicles along an inclined plane: sliding and rolling.

    Science.gov (United States)

    Abkarian, M; Lartigue, C; Viallat, A

    2001-04-01

    The migration of giant phospholipidic vesicles along an inclined plane in a quiescent fluid was observed as a function of the mass and the radius R of the vesicles, and as a function of the angle of inclination of the plane. Vesicles were swollen, and did not adhere to the substrate surface. It was observed from a side-view chamber that they have quasispherical shapes. The vesicles mainly slide along the plane, but also roll. The ratio omegaR/v of rotational to translational velocities is of the order of 0.15 for vesicles of radius ranging from 10 to 30 microm. Values of this ratio, and variations of v versus R, are well described by Goldman et al.'s model developed for the motion of rigid spheres close to a wall [Chem. Eng. Sci. 22, 637 (1967)]. In this framework, the thickness of the fluid film between the vesicle and the substrate derived from fitting experimental data was found to be equal to 48 nm.

  17. An inclined wall jet: Mean flow characteristics and effects of acoustic excitation

    Science.gov (United States)

    Lai, J. C. S.; Lu, D.

    2000-12-01

    The mean velocity field of a 30° inclined wall jet has been investigated using both hot-wire and laser Doppler anemometry (LDA). Provided that the nozzle aspect ratio is greater than 30 and the inclined wall angle (β) is less than 50°, LDA measurements for various β show that the reattachment length is independent of the nozzle aspect ratio and the nozzle exit Reynolds number (in the range 6670-13,340). There is general agreement between the reattachment lengths determined by LDA and those determined using wall surface oil film visualisation technique. The role of coherent structures arising from initial instabilities of a 30° wall jet has been explored by hot-wire spectra measurements. Results indicate that the fundamental vortex roll-up frequency in both the inner and outer shear layer corresponds to a Strouhal number (based on nozzle exit momentum thickness and velocity) of 0.012. The spatial development of instabilities in the jet has been studied by introducing acoustic excitation at a frequency corresponding to the shear layer mode. The formation of the fundamental and its first subharmonic has been identified in the outer shear layer. However, the development of the first subharmonic in the inner shear layer has been severely suppressed. Distributions of mean velocities, turbulence intensities and Reynolds shear stress indicate that controlled acoustic excitation enhances the development of instabilities and promotes jet reattachment to the wall, resulting in a substantially reduced recirculation flow region.

  18. Articulator-related registration and analysis of sagittal condylar inclination

    OpenAIRE

    Čimić, Samir; Kraljević Šimunković, Sonja; Simonić Kocijan, Sunčana; Matijević, Jurica; Dulčić, Nikša; Ćatić, Amir

    2015-01-01

    The purpose of this investigation was to study sagittal condylar inclination values within a uniform sample (Angle class I occlusion) using ‘articulator-related registration’ and Camper’s plane as a reference plane. The study was performed on a sample of 58 Angle class I subjects (mean age 25.1, SD 3.1). Measurements were performed with an ultrasonic jaw tracking device with six degrees of freedom. After a paraocclusal tray was fixed in the mouth, each subject had to make three protrusive ...

  19. Mining adjacent inclined coal seams of varying thickness

    Energy Technology Data Exchange (ETDEWEB)

    Batmanov, Yu.K.; Bakhtin, A.F.; Bulavka, E.I.

    1980-01-01

    In the Donbass coal basin a large number of thin coal seams located near other thicker coal seams are left. It is suggested that coal output from the Donbass could be increased by 100% and cost of mining could be lowered by 0.4-1.1 roubles per 1 ton of coal if thinner coal seams were also mined. Mining methods in the Donbass are analyzed from the point of view of reducing the cost of mining and increasing coal production. Recommendations on methods of mining thin inclined coal seams are given. (6 refs.) (In Russian)

  20. The Effect of Leading-Edge Sweep and Surface Inclination on the Hypersonic Flow Field Over a Blunt Flat Plate

    Science.gov (United States)

    Creager, Marcus O.

    1959-01-01

    An investigation of the effects of variation of leading-edge sweep and surface inclination on the flow over blunt flat plates was conducted at Mach numbers of 4 and 5.7 at free-stream Reynolds numbers per inch of 6,600 and 20,000, respectively. Surface pressures were measured on a flat plate blunted by a semicylindrical leading edge over a range of sweep angles from 0 deg to 60 deg and a range of surface inclinations from -10 deg to +10 deg. The surface pressures were predicted within an average error of +/- 8 percent by a combination of blast-wave and boundary-layer theory extended herein to include effects of sweep and surface inclination. This combination applied equally well to similar data of other investigations. The local Reynolds number per inch was found to be lower than the free-stream Reynolds number per inch. The reduction in local Reynolds number was mitigated by increasing the sweep of the leading edge. Boundary-layer thickness and shock-wave shape were changed little by the sweep of the leading edge.

  1. Finite element analysis of inclined nozzle-plate junctions

    International Nuclear Information System (INIS)

    Dixit, K.B.; Seth, V.K.; Krishnan, A.; Ramamurthy, T.S.; Dattaguru, B.; Rao, A.K.

    1979-01-01

    Estimation of stress concentration at nozzle to plate or shell junctions is a significant problem in the stress analysis of nuclear reactors. The topic is a subject matter of extensive investigations and earlier considerable success has been reported on analysis for the cases when the nozzle is perpendicular to the plate or is radial to the shell. Analytical methods for the estimation of stress concentrations for the practical situations when the intersecting nozzle is inclined to the plate or is non-radial to the shell is rather scanty. Specific complications arise in dealing with the junction region when the nozzle with circular cross-section meets the non-circular cut-out on the plate or shell. In this paper a finite element analysis is developed for inclined nozzles and results are presented for nozzle-plate junctions. A method of analysis is developed with a view to achieving simultaneously accuracy of results and simplicity in the choice of elements and their connectivity. The circular nozzle is treated by axisymmetric conical shell elements. The nozzle portion in the region around the junction and the flat plate is dealt with by triangular flat shell elements. Special transition elements are developed for joining the flat shell elements with the axisymmetric elements under non-axisymmetric loading. A substructure method of analysis is adopted which achieves considerable economy in handling the structure and also conveniently combines the different types of elements in the structure. (orig.)

  2. An Experimental Investigation on Inclined Negatively Buoyant Jets

    Directory of Open Access Journals (Sweden)

    Raed Bashitialshaaer

    2012-09-01

    Full Text Available An experimental study was performed to investigate the behavior of inclined negatively buoyant jets. Such jets arise when brine is discharged from desalination plants. A turbulent jet with a specific salinity was discharged through a circular nozzle at an angle to the horizontal into a tank with fresh water and the spatial evolution of the jet was recorded. Four different initial jet parameters were changed, namely the nozzle diameter, the initial jet inclination, the jet density and the flow rate. Five geometric quantities describing the jet trajectory that are useful in the design of brine discharge systems were determined. Dimensional analysis demonstrated that the geometric jet quantities studied, if normalized with the jet exit diameter, could be related to the densimetric Froude number. Analysis of the collected data showed that this was the case for a Froude number less than 100, whereas for larger values of the Froude number the scatter in the data increased significantly. As has been observed in some previous investigations, the slope of the best-fit straight line through the data points was a function of the initial jet angle (θ, where the slope increased with θ for the maximum levels (Ym studied, but had a more complex behavior for horizontal distances.

  3. Simplification of rat intubation on inclined metal plate.

    Science.gov (United States)

    Kastl, Sigrid; Kotschenreuther, U; Hille, B; Schmidt, J; Gepp, H; Hohenberger, W

    2004-12-01

    Small-animal intubation is often necessary during inhalation anesthesia to allow steady-state conditions for large operations and in vivo experiments in all fields of experimental surgery. In rats, placing an orotracheal tube is technically difficult primarily because of the small size of the subject and the lack of equipment specifically designed for this task. We describe a simple rat intubation technique in which the animal is suspended in dorsal recumbency on an inclined metal plate. The animal, anesthetized with ether, is fixed to a 70 degrees-inclined metal plate in a dorsal position by means of a Mersilene ribbon hooked around the upper incisors. This method of positioning the animal is the most important step in the intubation process and further facilitates the technique already described by other authors. A human otoscope was used as a laryngoscope, intubation was performed using the Seldinger technique, and a 14-gauge intravenous catheter served as an endotracheal tube. This inexpensive technique is quickly learned and can be used in any laboratory. Safe and reliable airway management can thus be achieved, permitting in vivo examinations and operations.

  4. Geosynchronous inclined orbits for high-latitude communications

    Science.gov (United States)

    Fantino, E.; Flores, R. M.; Di Carlo, M.; Di Salvo, A.; Cabot, E.

    2017-11-01

    We present and discuss a solution to the growing demand for satellite telecommunication coverage in the high-latitude geographical regions (beyond 55°N), where the signal from geostationary satellites is limited or unavailable. We focus on the dynamical issues associated to the design, the coverage, the maintenance and the disposal of a set of orbits selected for the purpose. Specifically, we identify a group of highly inclined, moderately eccentric geosynchronous orbits derived from the Tundra orbit (geosynchronous, eccentric and critically inclined). Continuous coverage can be guaranteed by a constellation of three satellites in equally spaced planes and suitably phased. By means of a high-precision model of the terrestrial gravity field and the relevant environmental perturbations, we study the evolution of these orbits. The effects of the different perturbations on the ground track (which is more important for coverage than the orbital elements themselves) are isolated and analyzed. The physical model and the numerical setup are optimized with respect to computing time and accuracy. We show that, in order to maintain the ground track unchanged, the key parameters are the orbital period and the argument of perigee. Furthermore, corrections to the right ascension of the ascending node are needed in order to preserve the relative orientation of the orbital planes. A station-keeping strategy that minimizes propellant consumption is then devised, and comparisons are made between the cost of a solution based on impulsive maneuvers and one with continuous thrust. Finally, the issue of end-of-life disposal is discussed.

  5. Non-dispersive traveling waves in inclined shallow water channels

    International Nuclear Information System (INIS)

    Didenkulova, Ira; Pelinovsky, Efim

    2009-01-01

    Existence of traveling waves propagating without internal reflection in inclined water channels of arbitrary slope is demonstrated. It is shown that traveling non-monochromatic waves exist in both linear and nonlinear shallow water theories in the case of a uniformly inclined channel with a parabolic cross-section. The properties of these waves are studied. It is shown that linear traveling waves should have a sign-variable shape. The amplitude of linear traveling waves in a channel satisfies the same Green's law, which is usually derived from the energy flux conservation for smoothly inhomogeneous media. Amplitudes of nonlinear traveling waves deviate from the linear Green's law, and the behavior of positive and negative amplitudes are different. Negative amplitude grows faster than positive amplitude in shallow water. The phase of nonlinear waves (travel time) is described well by the linear WKB approach. It is shown that nonlinear traveling waves of any amplitude always break near the shoreline if the boundary condition of the full absorption is applied.

  6. Dissipative descent: rocking and rolling down an incline

    Science.gov (United States)

    Balmforth, N. J.; Bush, J. W. M.; Vener, D.; Young, W. R.

    We consider the dynamics of a hollow cylindrical shell that is filled with viscous fluid and another, nested solid cylinder, and allowed to roll down an inclined plane. A mathematical model is compared to simple experiments. Two types of behaviour are observed experimentally: on steeper slopes, the device accelerates; on shallower inclines, the cylinders rock and roll unsteadily downhill, with a speed that is constant on average. The theory also predicts runaway and unsteady rolling motions. For the rolling solutions, however, the inner cylinder cannot be suspended in the fluid by the motion of the outer cylinder, and instead falls inexorably toward the outer cylinder. Whilst only occurs after an infinite time, the system slows progressively as the gap between the cylinders narrows, owing to heightened viscous dissipation. Such a deceleration is not observed in the experiments, suggesting that some mechanism limits the approach to contact. Coating the surface of the inner cylinder with sandpaper of different grades changes the rolling speed, consistent with the notion that surface roughness is responsible for limiting the acceleration.

  7. Breakdown of air pockets in downwardly inclined sewerage pressure mains.

    Science.gov (United States)

    Lubbers, C L; Clemens, F H L R

    2006-01-01

    In the Netherlands, wastewater is collected in municipal areas and transported to centralised WWTPs by an extensive system of pressure mains. Over the last decades these pressure mains did not receive much attention in terms of monitoring of performance or maintenance. A recent inventory showed that half of the pressure mains show an increased pressure loss for no directly obvious reason. One of the many causes that account for the reduction of the flow capacity is the occurrence of free gas in the pipeline. During dry weather periods with low flow velocities, gas may accumulate at high points in the system. Once the velocity increases during storm weather flow, the air pockets may be broken down and transported to the end of the system. A research study is started focussing on the description of the gas-water phenomena in wastewater pressure mains with respect to transportation of gas. An experimental facility is constructed for the study of multi-phase flow. This paper describes the preliminary results of experiments on breakdown rates of gas pockets as a function of inclination angle and water flow rate. The results show an increasing breakdown rate with increasing inclination angle.

  8. Dose and dose rate monitor

    International Nuclear Information System (INIS)

    Novakova, O.; Ryba, J.; Slezak, V.; Svobodova, B.; Viererbl, L.

    1984-10-01

    The methods are discussea of measuring dose rate or dose using a scintillation counte. A plastic scintillator based on polystyrene with PBD and POPOP activators and coated with ZnS(Ag) was chosen for the projected monitor. The scintillators were cylindrical and spherical in shape and of different sizes; black polypropylene tubes were chosen as the best case for the probs. For the counter with different plastic scintillators, the statistical error 2σ for natural background was determined. For determining the suitable thickness of the ZnS(Ag) layer the energy dependence of the counter was measured. Radioisotopes 137 Cs, 241 Am and 109 Cd were chosen as radiation sources. The best suited ZnS(Ag) thickness was found to be 0.5 μm. Experiments were carried out to determine the directional dependence of the detector response and the signal to noise ratio. The temperature dependence of the detector response and its compensation were studied, as were the time stability and fatigue manifestations of the photomultiplier. The design of a laboratory prototype of a dose rate and dose monitor is described. Block diagrams are given of the various functional parts of the instrument. The designed instrument is easiiy portable, battery powered, measures dose rates from natural background in the range of five orders, i.e., 10 -2 to 10 3 nGy/s, and allows to determine a dose of up to 10 mGy. Accouracy of measurement in the energy range of 50 keV to 1 MeV is better than +-20%. (E.S.)

  9. Improvement in greenhouse solar drying using inclined north wall reflection

    Energy Technology Data Exchange (ETDEWEB)

    Sethi, V.P. [Department of Mechanical Engineering, Punjab Agricultural University, Ludhiana 141004, Punjab (India); Arora, Sadhna [Department of Processing and Food Engineering, Punjab Agricultural University, Ludhiana 141004, Punjab (India)

    2009-09-15

    A conventional greenhouse solar dryer of 6 m{sup 2} x 4 m{sup 2} floor area (east-west orientation) was improved for faster drying using inclined north wall reflection (INWR) under natural as well as forced convection mode. To increase the solar radiation availability onto the product (to be dried) during extreme summer months, a temporary inclined wall covered with aluminized reflector sheet (of 50 {mu}m thickness and reflectance 0.93) was raised inside the greenhouse just in front of the vertical transparent north wall. By doing so, product fully received the reflected beam radiation (which otherwise leaves through the north wall) in addition to the direct total solar radiation available on the horizontal surface during different hours of drying. The increment in total solar radiation input enhanced the drying rate of the product by increasing the inside air and crop temperature of the dryer. Inclination angle of the reflective north wall with vertical ({beta}) was optimized for various selective widths of the tray W (1.5, 2, 2.5 and 3 m) and for different realistic heights of existing vertical north wall (h) at 25 N, 30 N and 35 N latitudes (hot climatic zones). Experimental performance of the improved dryer was tested during the month of May 2008 at Ludhiana (30.56 N) climatic conditions, India by drying bitter gourd (Momordica charantia Linn) slices. Results showed that by using INWR under natural convection mode of drying, greenhouse air and crop temperature increased by 1-6.7 C and 1-4 C, respectively, during different drying hours as compared to, when INWR was not used and saved 13.13% of the total drying time. By using INWR under forced convection mode of drying, greenhouse air and crop temperature increased by 1-4.5 C and 1-3 C, respectively, during different drying hours as compared to, when INWR was not used and saved 16.67% of the total drying time. (author)

  10. Hydraulic shock waves in an inclined chute contraction

    Science.gov (United States)

    Jan, C.-D.; Chang, C.-J.

    2009-04-01

    A chute contraction is a common structure used in hydraulic engineering for typical reasons such as increase of bottom slope, transition from side channel intakes to tunnel spillways, reduction of chute width due to bridges, transition structures in flood diversion works, among others. One of the significant chute contractions in Taiwan is that used in the Yuanshantzu Flood Diversion Project of Keelung River. The diversion project is designed to divert flood water from upper Keelung River into East Sea with a capasity of 1,310 cubic meters per second for mitigating the flood damage of lower part of Keelung River basin in Northern Taiwan. An inclined chute contraction is used to connect Keelung River and a diversion turnel. The inlet and outlet works of the diversion project is located at Ruifang in the Taipei County of north Taiwan. The diameter of diversion tunnel is 12 meters and the total length of tunnel is 2,484 meters. The diversion project has been completed and successfully executed many times since 2004 to lower the water level of Keelung River in typhoon seasons for avioding flooding problems in the lower part of Keelung River basin. Flow in a chute contraction has complicated flow pattern due to the existence of shock waves in it. A simple and useful calculation procedure for the maximum height and its position of shock waves is essentially needed for the preliminary design stage of a chute contraction. Hydraulic shock waves in an inclined chute contraction were experimentally and numerically investigated in this study with the consideration of the effects of sidewall deflection angle, bottom inclination angle and Froude number of approaching flow. The flow pattern of hydraulic shock waves in a chute contraction was observed. The main issue of designing chute contraction is to estimate the height and position of maximum shock wave for the consideration of freeboards. Achieving this aim, the experimental data are adopted and analyzed for the shock angle

  11. Experimental Study of Heat Transfer Enhancements from Array of Alternate Rectangular Dwarf Fins at Different Inclinations

    Science.gov (United States)

    Awasarmol, Umesh Vandeorao; Pise, Ashok T.

    2018-02-01

    The main objective of this experimental work is to investigate and compare heat transfer enhancement of alternate dwarf fin array at different angles of inclination. In this study, the steady state heat transfer from the full length fin arrays and alternate dwarf fin arrays are measured in natural convection and radiation environment. Largest increase in the Nusselt number was achieved with alternate dwarf fin at angle of orientation 90°, which shows about 28% enhanced heat transfer coefficient as opposed to the full-length fin array with 25% saving in material. In case of non-black FAB, contribution of radiation heat transfer is found to be very small nearly within 1% of the heater input. After coating lamp black contribution of radiation heat transfer is found to increase to about 3-4% of the heater input in the range of temperatures considered in this study.

  12. Strength Calculation of Inclined Sections of Reinforced Concrete Elements under Transverse Bending

    Science.gov (United States)

    Filatov, V. B.

    2017-11-01

    The authors propose a design model to determine the strength of inclined sections of bent reinforced concrete elements without shear reinforcement for the action of transverse force taking into account the aggregate interlock forces in the inclined crack. The calculated dependences to find out the components of forces acting in an inclined section are presented. The calculated dependences are obtained from the consideration of equilibrium conditions of the block over the inclined crack. A comparative analysis of the experimental values of the failure loads of the inclined section and the theoretical values obtained for the proposed dependencies and normative calculation methods is performed. It is shown that the proposed design model makes it possible to take into account the effect the longitudinal reinforcement percentage has on the inclined section strength, the element cross section height without the introduction of empirical coefficients which contributes to an increase in the structural safety of design solutions including the safety of high-strength concrete elements.

  13. Development of a semi-analytical method for calculation of the radial dose profile for proton beams in the 0.5-1.0 MeV energy range

    International Nuclear Information System (INIS)

    Wiklund, Kristin

    2004-07-01

    There has been an increased interest in the application of protons for radiation therapy during the last decades. The main reason for this is the advantageous shape of the proton dose profile, which offers the possibility of improved treatment outcome. Proton beams and other light ions have because of this observed phenomenon a high efficiency to inflict lethal damage to tumor tissue while sparing normal tissue. Treatment with ions heavier than protons, have also been considered on the basis of radiological arguments. Recently scientists have discovered that not only high-energy electrons inflict severe damage to the DNA, but also low-energy electrons. Those electrons can be produced when protons with energy between 0.5-1 MeV interact with matter. High-accuracy calculations of dose distributions inside tumors and the surrounding tissue are essential for assessing the effectiveness of a given treatment in terms of probability of tumor control and of radiation-induced complications. The use of Monte Carlo methods to simulate radiation transport has become the most accurate means of predicting absorbed dose distributions and other quantities like numbers of track ends, track lengths and angular distributions. Today, there no accurate Monte-Carlo codes for proton transport, not even for low-energy electron transport. Much work is devoted to develop a Monte Carlo code for this purpose. However, for most practical cases in treatment planning, an advantageous solution has been found by combining the intrinsic accuracy of Monte Carlo methods with the swiftness of analytical techniques. In this work, a simple semi-analytical method is developed for fast dose distribution calculations for protons with energy range 0.5-1 MeV. The major part of the energy loss when protons traverse tissue, ends up in the ionizations of the target atoms. The double differential cross sections for this secondary electron production is calculated with Continuous distorted waves-eikonal initial

  14. A measurement of the muon number in showers using inclined events detected at the Pierre Auger Observatory

    Directory of Open Access Journals (Sweden)

    Rodriguez G.

    2013-06-01

    Full Text Available The average muon content of measured showers with zenith angles between 62∘ and 80∘ detected at the Pierre Auger Observatory is obtained as a function of shower energy using a reconstruction method specifically designed for inclined showers and the hybrid character of the detector. The reconstruction of inclined showers relies on a comparison between the measured signals at ground and reference patterns at ground level from which an overall normalization factor is obtained. Since inclined showers are dominated by muons this factor gives the relative muon size. It can be calibrated using a subsample of showers simultaneously recorded with the fluorescence detector (FD and the surface detector (SD which provides an independent calorimetric measurement of the energy. The muon size obtained for each shower becomes a measurement of the relative number of muons with respect to the reference distributions. The precision of the measurement is assessed using simulated events which are reconstructed using exactly the same procedure. We compare the relative number of muons versus energy as obtained to simulations. Proton simulations with QGSJETII show a factor of 2.13 ± 0.04(stat ± 0.11(sys at 1019eV without significant variations in the energy range explored between 4 × 1018eV to 7 × 1019eV. We find that none of the current shower models, neither for proton nor for iron primaries, are able to predict as many muons as are observed.

  15. Unique operations for a highly inclined, elliptical, geosynchronous satellite

    Science.gov (United States)

    Anglin, Patrick T.; Briskman, Robert D.

    2004-08-01

    The first space segment devoted to a Digital Audio Radio Service (DARS) for the Continental United States (CONUS) was established when the last satellite of a three satellite constellation (Flight Models FM-1, FM-2 and FM-3) was launched in November 2000. Each satellite is in a highly inclined, elliptical, geosynchronous orbit that is separated by 120° in Right Angle of the Ascending Node (RAAN) from the other two satellites' orbits. This results in an 8 h phasing in ground track between each satellite. These distinct orbits provide superior look angles and signal availability to mobile receivers in the northern third of the United States when compared to geostationary satellites. However, this unique orbital constellation results in some particular performance and operational differences from geostationary orbit satellites. Some of these are: Earth Sensor noise, maneuver implementation and power management. Descriptions and performance improvements of these orbit specific operations are detailed herein.

  16. Simulation of Solar Radiation Incident on Horizontal and Inclined Surfaces

    Directory of Open Access Journals (Sweden)

    MA Basunia

    2012-12-01

    Full Text Available A computer model was developed to simulate the hourly, daily and monthly average of daily solar radiation on horizontal and inclined surfaces. The measured hourly and daily solar radiation was compared with simulated radiation, and favourable agreement was observed for the measured and predicted values on clear days. The measured and simulated monthly averages of total (diffuse and beam daily solar radiation were compared and a reasonable agreement was observed for a number of stations in Japan. The simulation showed that during the rice harvesting season, September to October, there is a daily average of 14.7 MJ/m2 of solar irradiation on a horizontal surface in Matsuyama, Japan. There is a similar amount of solar radiation on a horizontal surface during the major rice harvesting season, November to December, in Bangladesh. This radiation can be effectively utilized for drying rough rice and other farm crops.

  17. Inclined nanoimprinting lithography-based 3D nanofabrication

    Science.gov (United States)

    Liu, Zhan; Bucknall, David G.; Allen, Mark G.

    2011-06-01

    We report a 'top-down' 3D nanofabrication approach combining non-conventional inclined nanoimprint lithography (INIL) with reactive ion etching (RIE), contact molding and 3D metal nanotransfer printing (nTP). This integration of processes enables the production and conformal transfer of 3D polymer nanostructures of varying heights to a variety of other materials including a silicon-based substrate, a silicone stamp and a metal gold (Au) thin film. The process demonstrates the potential of reduced fabrication cost and complexity compared to existing methods. Various 3D nanostructures in technologically useful materials have been fabricated, including symmetric and asymmetric nanolines, nanocircles and nanosquares. Such 3D nanostructures have potential applications such as angle-resolved photonic crystals, plasmonic crystals and biomimicking anisotropic surfaces. This integrated INIL-based strategy shows great promise for 3D nanofabrication in the fields of photonics, plasmonics and surface tribology.

  18. Segregation in inclined flows of binary mixtures of spheres

    Directory of Open Access Journals (Sweden)

    Larcher Michele

    2017-01-01

    Full Text Available We outline the equations that govern the evolution of segregation of a binary mixture of spheres in flows down inclines. These equations result from the mass and momentum balances of a kinetic theory for dense flows of inelastic spheres that interact through collisions. The theory employed for segregation is appropriate for particles with relatively small differences in size and mass. The flow of the mixture is assumed to reach a fully developed state much more rapidly than does the concentrations of the two species. We illustrate the predictions of the theory for a mixture of spheres of the same diameter but different masses and for spheres of different diameters but nearly the same mass. We show the evolution of the profiles of the concentration fractions of the two types of spheres and the profiles in the final, steady state. The latter compare favourably with those obtained in discrete-element numerical simulations.

  19. Method and apparatus for logging inclined earth boreholes

    International Nuclear Information System (INIS)

    Youmans, A.H.

    1981-01-01

    An improved technique is provided for comparing the velocity of an elongated well logging instrument traversing an inclined earth borehole with the playout velocity of the well logging cable at the earth's surface to control both the cable hoist drum rotation and the rate of movement of the subsurface instrument and thus insure cable playout is in equilibrium with the logging instrument movement. Method and apparatus are described for detecting any reduction in movement of the logging instrument through the borehole and for reducing the velocity of the logging cable playout in response thereto by reducing drum rotation. Further, when the velocity of cable playout slows to a preselected value, a monitoring circuit generates control signals which actuate a means of power attached to or integral with the logging instrument which, upon initiation, apply a force to move the logging instrument upward or downward within the borehole

  20. Deformation Analysis of Fixed Bearing Inclined Plane Thrust Bearing

    Directory of Open Access Journals (Sweden)

    LI Yong--hai

    2017-02-01

    Full Text Available According to the theory of lubrication,Numerical simulation of the deformation of the thrust bearing of the fixed inclined plane was carried out,by finite element numerical analysis method and using the ANSYS software. The mathematical model of the oil film shape control equations about of the deformation and bearing is established. Analytical result showed that the force caused the tile surface generating concave deformation,and convex deformation increased with the height and the size of the load and bearing;Tile surface temperature generated convex deformation and increased with the height and the size of the temperature of bearing bush;The actual deformation of the tile surface is the superposition of the force and the thermal deformation. This conclusion can provide reference for the design and the application of thrust bearing,to reduce the tile surface,which is not conducive to the carrying capacity of the concave deformation.

  1. Transient flow and heat transfer phenomena in inclined wavy films

    Energy Technology Data Exchange (ETDEWEB)

    Serifi, Katerina; Bontozoglou, Vasilis [Department of Mechanical and Industrial Engineering, University of Thessaly, 38334, Volos (Greece); Malamataris, Nikolaos A. [Department of Mechanical Engineering, Technological Educational Institution of Western Macedonia, 50100, Kila Kozani (Greece)

    2004-08-01

    A finite-element numerical scheme is used to study rigorously the flow of an inclined liquid film and the heat transfer from the constant-temperature wall. Regular inlet disturbances are predicted to evolve into periodic or solitary waves depending on the frequency of the forcing. At very low disturbance frequencies parasitic crests appear and the regularity of the wave-train is lost. The effect of a solitary wave-train on heat transfer from the wall is studied, and it is predicted that a stationary temperature distribution develops with periodic flux variation that follows the waves. The thinning of the substrate between successive humps combines with the effect of convection at the crest and tail of the solitary humps to produce heat transfer enhancement significantly above the conduction limit. (authors)

  2. Soil-structure interaction on inclined soil layers

    International Nuclear Information System (INIS)

    Massa, G.; De Stefano, R.

    1983-01-01

    The case history presented deals with a Category I building having two-thirds of its base founded on a wedge of hard material. This wedge is underlain by an inclined layer of softer material, which also directly supports the remaining one-third of the foundation. The inclined layer is underlain by a third material, possessing large stiffness and extending to great depth. This case is analyzed with the methodology described below: - Determination of the static soil compliances by discretizing the foundation area into a number of strips and taking the soil profile as horizontally layered under each strip. Lumped parameter soil compliances for the whole foundation are obtained by weighting the contributions to stiffness in proportion to the area of each strip. - Definition of the degree of coupling between modes. The soil compliances defined in the previous step include coupling between the vertical and rocking modes and the horizontal and torsional modes through the positioning of the corresponding soil springs. The degree of coupling is checked through a static finite element analysis. - Frequency correction of the static soil compliances taking into account the inhomogeneity of the foundation conditions. The correction is based on obtaining dynamic stiffness coefficients for extreme configurations of the soil profile. - Assessment of the sliding potential of the structure under earthquake loading, considering eccentricities of the dynamic forces and non-uniform friction resistance over the foundation area, accounting for the frictional capacity of the different bearing materials. It is concluded that the simplified technique can provide accurate soil compliances, coupling and frequency corrections for soil-structure interaction on sloping layers, and an appropriate assessment of the sliding potential. (orig./HP)

  3. The influence of follow-up on DS02 low-dose ranges with a significant excess relative risk of all solid cancer in the Japanese A-bomb survivors

    Energy Technology Data Exchange (ETDEWEB)

    Walsh, Linda; Schneider, Uwe [University of Zuerich, Department of Physics, Science Faculty, Zurich (Switzerland)

    2016-11-15

    Determinations of the lowest colon dose, D{sub min}, below which there is a statistically significant excess relative risk of all solid cancer, when analyses are restricted to the range [0, D{sub min}], are of current interest in research related to radiation protection and risk assessment. In reviewing recent cancer mortality reports on the Life Span Study (LSS) of Japanese A-bomb survivors, reported D{sub min} values were found to vary between different reports. The report 12 (follow-up: 1950-1990) found a D{sub min} of 50 mGy, but the most recent report 14 (follow-up: 1950-2003) found a D{sub min} of 200 mGy. There were small dosimetry changes between report 12, which used DS86, and report 14, which used DS02, but these changes are unlikely to account for a difference in D{sub min} of a factor of 4. This short communication examines the reasons for this difference in D{sub min} by presenting further investigations into D{sub min} using different trial values for D{sub min} and various follow-up time spans, all with the same DS02 dosimetry. Magnitudes of the low-dose risks in different dose ranges are also presented. It is shown here that the main influence on D{sub min} comes from the length of follow-up and a D{sub min} of 50 mGy may also be obtained with the most recent LSS mortality data and DS02, if a restricted follow-up is analyzed. A systematic trend was evident of lower D{sub min} values for earlier mortality follow-up periods, consistent with information from earlier LSS reports. Although it may seem surprising that the D{sub min} increases with longer follow-up and better statistics, this systematic trend appears to be a consequence of decreasing mortality risks with longer follow-up, even though the error bars on the risks are getting smaller with increasing follow-up. These systematic trends also persisted after accounting for differences between baseline cancer rates for two groups of survivors who were either proximal or distal to the A

  4. NUMERICAL SIMULATION OF EXCITATION AND PROPAGATION OF HELIOSEISMIC MHD WAVES: EFFECTS OF INCLINED MAGNETIC FIELD

    International Nuclear Information System (INIS)

    Parchevsky, K. V.; Kosovichev, A. G.

    2009-01-01

    Investigation of propagation, conversion, and scattering of MHD waves in the Sun is very important for understanding the mechanisms of observed oscillations and waves in sunspots and active regions. We have developed a three-dimensional linear MHD numerical model to investigate the influence of the magnetic field on excitation and properties of the MHD waves. The results show that surface gravity waves (f-modes) are affected by the background magnetic field more than acoustic-type waves (p-modes). Comparison of our simulations with the time-distance helioseismology results from Solar and Heliospheric Observatory/MDI shows that the amplitude of travel time variations with azimuth around sunspots caused by the inclined magnetic field does not exceed 25% of the observed amplitude even for strong fields of 1400-1900 G. This can be an indication that other effects (e.g., background flows and nonuniform distribution of the magnetic field) can contribute to the observed azimuthal travel time variations. The azimuthal travel time variations caused by the wave interaction with the magnetic field are similar for simulated and observed travel times for strong fields of 1400-1900 G if Doppler velocities are taken at the height of 300 km above the photosphere where the plasma parameter β << 1. For the photospheric level the travel times are systematically smaller by approximately 0.12 minutes than for the height of 300 km above the photosphere for all studied ranges of the magnetic field strength and inclination angles. Numerical MHD wave modeling and new data from the HMI instrument of the Solar Dynamics Observatory will substantially advance our knowledge of the wave interaction with strong magnetic fields on the Sun and improve the local helioseismology diagnostics.

  5. Frictional characteristics of erythrocytes on coated glass plates subject to inclined centrifugal forces.

    Science.gov (United States)

    Kandori, Takashi; Hayase, Toshiyuki; Inoue, Kousuke; Funamoto, Kenichi; Takeno, Takanori; Ohta, Makoto; Takeda, Motohiro; Shirai, Atsushi

    2008-10-01

    In recent years a diamond-like carbon (DLC) film and a 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer have attracted attention as coating materials for implantable artificial organs or devices. When these materials are coated on vascular devices, compatibility to blood is an important problem. The present paper focuses on friction characteristics of erythrocytes to these coating materials in a medium. With an inclined centrifuge microscope developed by the authors, observation was made for erythrocytes moving on flat glass plates with and without coating in a medium of plasma or saline under the effect of inclined centrifugal force. Friction characteristics of erythrocytes with respect to these coating materials were then measured and compared to each other to characterize DLC and MPC as coating materials. The friction characteristics of erythrocytes in plasma using the DLC-coated and noncoated glass plates are similar, changing approximately proportional to the 0.5th power of the cell velocity. The cells stick to these plates in saline as well, implying the influence of plasma protein. The results using the MPC-coated plate in plasma are similar to those of the other plates for large cell velocities, but deviate from the other results with decreased cell velocity. The results change nearly proportional to the 0.75th power of the cell velocity in the range of small velocities. The results for the MPC-coated plate in saline are similar to that in plasma but somewhat smaller, implying that the friction characteristics for the MPC-coated plate are essentially independent of plasma protein.

  6. New inclination changing eclipsing binaries in the Magellanic Clouds

    Science.gov (United States)

    Juryšek, J.; Zasche, P.; Wolf, M.; Vraštil, J.; Vokrouhlický, D.; Skarka, M.; Liška, J.; Janík, J.; Zejda, M.; Kurfürst, P.; Paunzen, E.

    2018-01-01

    Context. Multiple stellar systems are unique laboratories for astrophysics. Analysis of their orbital dynamics, if well characterized from their observations, may reveal invaluable information about the physical properties of the participating stars. Unfortunately, there are only a few known and well described multiple systems, this is even more so for systems located outside the Milky Way galaxy. A particularly interesting situation occurs when the inner binary in a compact triple system is eclipsing. This is because the stellar interaction, typically resulting in precession of orbital planes, may be observable as a variation of depth of the eclipses on a long timescale. Aims: We aim to present a novel method to determine compact triples using publicly available photometric data from large surveys. Here we apply it to eclipsing binaries (EBs) in Magellanic Clouds from OGLE III database. Our tool consists of identifying the cases where the orbital plane of EB evolves in accord with expectations from the interaction with a third star. Methods: We analyzed light curves (LCs) of 26121 LMC and 6138 SMC EBs with the goal to identify those for which the orbital inclination varies in time. Archival LCs of the selected systems, when complemented by our own observations with Danish 1.54-m telescope, were thoroughly analyzed using the PHOEBE program. This provided physical parameters of components of each system. Time dependence of the EB's inclination was described using the theory of orbital-plane precession. By observing the parameter-dependence of the precession rate, we were able to constrain the third companion mass and its orbital period around EB. Results: We identified 58 candidates of new compact triples in Magellanic Clouds. This is the largest published sample of such systems so far. Eight of them were analyzed thoroughly and physical parameters of inner binary were determined together with an estimation of basic characteristics of the third star. Prior to our

  7. Aerodynamics of wing-assisted incline running in birds.

    Science.gov (United States)

    Tobalske, Bret W; Dial, Kenneth P

    2007-05-01

    Wing-assisted incline running (WAIR) is a form of locomotion in which a bird flaps its wings to aid its hindlimbs in climbing a slope. WAIR is used for escape in ground birds, and the ontogeny of this behavior in precocial birds has been suggested to represent a model analogous to transitional adaptive states during the evolution of powered avian flight. To begin to reveal the aerodynamics of flap-running, we used digital particle image velocimetry (DPIV) and measured air velocity, vorticity, circulation and added mass in the wake of chukar partridge Alectoris chukar as they engaged in WAIR (incline 65-85 degrees; N=7 birds) and ascending flight (85 degrees, N=2). To estimate lift and impulse, we coupled our DPIV data with three-dimensional wing kinematics from a companion study. The ontogeny of lift production was evaluated using three age classes: baby birds incapable of flight [6-8 days post hatching (d.p.h.)] and volant juveniles (25-28 days) and adults (45+ days). All three age classes of birds, including baby birds with partially emerged, symmetrical wing feathers, generated circulation with their wings and exhibited a wake structure that consisted of discrete vortex rings shed once per downstroke. Impulse of the vortex rings during WAIR was directed 45+/-5 degrees relative to horizontal and 21+/-4 degrees relative to the substrate. Absolute values of circulation in vortex cores and induced velocity increased with increasing age. Normalized circulation was similar among all ages in WAIR but 67% greater in adults during flight compared with flap-running. Estimated lift during WAIR was 6.6% of body weight in babies and between 63 and 86% of body weight in juveniles and adults. During flight, average lift was 110% of body weight. Our results reveal for the first time that lift from the wings, rather than wing inertia or profile drag, is primarily responsible for accelerating the body toward the substrate during WAIR, and that partially developed wings, not yet

  8. Efficacy and Safety of Bococizumab (RN316/PF-04950615), a Monoclonal Antibody Against Proprotein Convertase Subtilisin/Kexin Type 9, in Hypercholesterolemic Japanese Subjects Receiving a Stable Dose of Atorvastatin or Treatment-Naive - Results From a Randomized, Placebo-Controlled, Dose-Ranging Study.

    Science.gov (United States)

    Yokote, Koutaro; Kanada, Shigeto; Matsuoka, Osamu; Sekino, Hisakuni; Imai, Keiji; Tabira, Junichi; Matsuoka, Nobushige; Chaudhuri, Sandip; Teramoto, Tamio

    2017-09-25

    A Phase 2, dose-ranging study of bococizumab, a monoclonal anti-proprotein convertase subtilisin/kexin type 9 antibody, was conducted in Japanese subjects to assess its efficacy, safety, and tolerability in this population.Methods and Results:Two different hypercholesterolemic study populations were enrolled concurrently: Japanese subjects with uncontrolled low-density lipoprotein cholesterol (LDL-C) despite atorvastatin treatment (LDL-C ≥100 mg/dL; n=121), and Japanese subjects naive to lipid-lowering agents and with LDL-C ≥130 mg/dL (n=97). Subjects within each study population were randomized to bococizumab 50, 100, or 150 mg, or placebo, q14D for 16 weeks; an open-label ezetimibe 10 mg daily arm was also included for the atorvastatin-treated population. Significant, dose-dependent reductions in fasting LDL-C levels were observed in all bococizumab arms of both study populations at Weeks 12 and 16 (adjusted mean percent changes from baseline: 54.1-76.7% for atorvastatin-treated subjects and 47.7-66.8% for treatment-naive subjects; P<0.001 vs. placebo for all). Bococizumab also caused dose-dependent changes in other lipid parameters in both study populations at Weeks 12 and 16. No serious adverse events (AEs) related to bococizumab treatment occurred and all treatment-emergent AEs were mild or moderate in severity. No dose-dependent relationship between bococizumab treatment and development of anti-drug antibodies was observed. Bococizumab was well tolerated and significantly reduced fasting LDL-C in atorvastatin-treated and treatment-naive hypercholesterolemic Japanese subjects. (Clinicaltrials.gov identifier: NCT02055976.).

  9. Percentiles relative to maxillary permanent canine inclination by age: a radiologic study.

    Science.gov (United States)

    Alessandri Bonetti, Giulio; Zanarini, Matteo; Danesi, Margherita; Parenti, Serena Incerti; Gatto, Maria Rosaria

    2009-10-01

    Few studies have investigated developmental norms for maxillary permanent canine eruption. In this observational cross-sectional study, we aimed to provide an age-related description of the percentiles relative to canine inclination in a large sample of nonorthodontic patients. Associations between inclination and sector were also analyzed. Canine inclination and sector location were measured on 1020 panoramic radiographs obtained from subjects of white ancestry aged between 8 and 11 years not seeking orthodontic treatment. The total sample comprised 2037 canines. Canine inclination increases between 8 and 9 years and decreases between 9 and 11 years. The greatest value for each percentile is at 9 years. A linear model should be hypothesized for differences in canine inclination between 2 successive ages in correspondence to each percentile. The proportion of sector 2 canines decreases and that of sector 1 increases with age. In the same age group, the inclination generally decreases as the sector decreases. Percentiles by age show the average canine inclination in a certain population. Further studies are required to verify whether percentiles can be a diagnostic aid for determining normal canine inclination at a given age and for quantifying the risk of canine impaction or adjacent root resorption.

  10. Variation of the Friction Coefficient for a Cylinder Rolling down an Inclined Board

    Science.gov (United States)

    Yan, Zixiang; Xia, Heming; Lan, Yueheng; Xiao, Jinghua

    2018-01-01

    A cylinder rolling down an inclined board is a commonly seen and interesting object to study and it is also easy to experiment with and model. Following what has become a popular practice, we use smartphones to measure the angular acceleration of a cylinder rolling down a plane of different inclining angles. The friction force deviates from the…

  11. The effect of surfactants on upward air-water pipe flow at various inclinations

    NARCIS (Netherlands)

    van Nimwegen, A.T.; Portela, L.; Henkes, R.A.W.M.

    2016-01-01

    In this work, we extend our previous efforts on the effect of surfactants on air-water flow in a vertical pipe by also considering pipe inclinations between 20° (with respect to horizontal) and vertical. For air-water flow, independent of the inclination, there is a regular annular flow at large

  12. Comparison of normal permanent and primary dentition sagittal tooth-crown inclinations of Japanese females.

    Science.gov (United States)

    Inada, Emi; Saitoh, Issei; Hayasaki, Haruaki; Iwase, Yoko; Kubota, Naoko; Takemoto, Yoshihiko; Yamasaki, Youichi

    2012-01-01

    The purpose of this study was to clarify the characteristics of permanent and primary tooth-crown inclinations. Landmark points from cephalograms and dental casts of two groups; 23 women (mean 20.3 +/- 3.3 years) and 11 girls (mean 5.2 +/- 0.1 years) were digitized, and the coordinates were integrated and transformed to a standardized plane. The 3-dimensional crown inclinations were projected on the sagittal plane, and the angles between the tooth vectors and the FH plane were calculated. An independent-group t-test was used to test for group differences of each tooth inclination, and correlation coefficients were generated for the inclination angles among the permanent and primary teeth. Most maxillary tooth-crown inclinations showed significant age-related differences, while only the second premolar and primary second molar differed significantly in the mandible. The maxillary molars were parallel to the corresponding mandibular molars and correlated with each other, but the primary molars were not. Significant correlations were found between inclinations of most permanent teeth, but not the primary teeth. Maxillary tooth-crown inclinations change during growth, but tooth-crown inclinations of the mandibular teeth do not.

  13. Dry granular flows down an inclined channel: experimental investigations on the frictional-collisional regime.

    Science.gov (United States)

    Ancey, Christophe

    2002-01-01

    This paper presents experimental results on dry granular flows down an inclined rough channel. Different flow regimes were identified depending on the Froude number. For Froude numbers exceeding a critical value (function of the channel slope), flow was characterized by a fairly linear velocity profile and a discharge equation in the form q varies with h(n) with q the flow rate per unit width, h the flow depth, and n an exponent in the range 2-3 (regime A). When the Froude number was lower than the critical value, the flow was characterized by a convex velocity profile and a discharge equation of the form q varies with h(n), with n ranging from 0.97 to 1.16, producing the striking result that the mean velocity was constant for a given inclination of the channel (regime B). Experimental data were used to test three theoretical models developed to describe dry granular flows in a frictional-collisional regime. Savage's model provides results that capture experimental trends well and yield the correct magnitude for velocity and discharge for regime A, but it reproduces the dependence of the discharge on the channel slope for only a narrow range of slopes [S. B. Savage, in U.S./Japan Seminar on New Models and Constitutive Relations in the Mechanics of Granular Materials, Ithaca, 1982, edited by J. T. Jenkins and M. Satake (Elsevier Science Publishers, Amsterdam, 1982), p. 261]. In contrast, Mills et al.'s model is less refined and requires fitting an input parameter to give the correct magnitude of velocity but it successfully accounts for the variation in the discharge with slope for regime A for a wide range of slopes [Mills, Loggia, and Tixier, Europhys. Lett. 45, 733 (1999); Eur. Phys. J. E 1, 5 (2000)]. Ancey and Evesque's model is also crude in determining the density profile but manages to provide velocity profiles and discharge equations in good agreement with experimental data for regime B [C. Ancey and P. Evesque, Phys. Rev. E 62, 8349 (2000)].

  14. Space Station Freedom assembly and operation at a 51.6 degree inclination orbit

    Science.gov (United States)

    Troutman, Patrick A.; Brewer, Laura M.; Heck, Michael L.; Kumar, Renjith R.

    1993-01-01

    This study examines the implications of assembling and operating Space Station Freedom at a 51.6 degree inclination orbit utilizing an enhanced lift Space Shuttle. Freedom assembly is currently baselined at a 220 nautical mile high, 28.5 degree inclination orbit. Some of the reasons for increasing the orbital inclination are (1) increased ground coverage for Earth observations, (2) greater accessibility from Russian and other international launch sites, and (3) increased number of Assured Crew Return Vehicle (ACRV) landing sites. Previous studies have looked at assembling Freedom at a higher inclination using both medium and heavy lift expendable launch vehicles (such as Shuttle-C and Energia). The study assumes that the shuttle is used exclusively for delivering the station to orbit and that it can gain additional payload capability from design changes such as a lighter external tank that somewhat offsets the performance decrease that occurs when the shuttle is launched to a 51.6 degree inclination orbit.

  15. Efficient light trapping in silicon inclined nanohole arrays for photovoltaic applications

    Science.gov (United States)

    Deng, Can; Tan, Xinyu; Jiang, Lihua; Tu, Yiteng; Ye, Mao; Yi, Yasha

    2018-01-01

    Structural design with high light absorption is the key challenge for thin film solar cells because of its poor absorption. In this paper, the light-trapping performance of silicon inclined nanohole arrays is systematically studied. The finite difference time domain method is used to calculate the optical absorption of different inclination angles in different periods and diameters. The results indicate that the inclined nanoholes with inclination angles between 5° and 45° demonstrate greater light-trapping ability than their counterparts of the vertical nanoholes, and they also show that by choosing the optimal parameters for the inclined nanoholes, a 31.2 mA/cm2 short circuit photocurrent density could be achieved, which is 10.25% higher than the best vertical nanohole system and 105.26% higher than bare silicon with a thickness of 2330 nm. The design principle proposed in this work gives a guideline for choosing reasonable parameters in the application of solar cells.

  16. Numerical Analysis of Aerodynamic Characteristics of the Finned Surfaces with Cross-inclined Fins

    Directory of Open Access Journals (Sweden)

    Lagutin A. E.

    2016-12-01

    Full Text Available This paper presents results of numerical research and analyses air-side hydraulic performance of tube bundles with cross inclined fins. The numerical simulation of the fin-tube heat exchanger was performed using the Comsol Femlab software. The results of modeling show the influence of fin inclination angle and tube pitch on hydraulic characteristics of finned surfaces. A series of numerical tests were carried out for tube bundles with different inclination angles (γ =900, 850, 650, 60, the fin pitch u=4 mm. The results indicate that tube bundles with cross inclined fins can significantly enhance the average integral value of the air flow rate in channel between fins in comparison with conventional straight fins. Aerodynamic processes on both sides of modificated channel between inclined fins were analyzed. The verification procedures for received results of numerical modeling with experimental data were performed.

  17. Stability of film boiling on inclined plates and spheres

    Science.gov (United States)

    Aursand, Eskil; Hammer, Morten; Munkejord, Svend Tollak; Müller, Bernhard; Ytrehus, Tor

    2017-11-01

    In film boiling, a continuous sub-millimeter vapor film forms between a liquid and a heated surface, insulating the two from each other. While quite accurate steady state solutions are readily obtained, the intermediate Reynolds numbers can make transient analysis challenging. The present work is a theoretical study of film boiling instabilities. We study the formation of travelling waves that are a combination of Kelvin-Helmholtz and the Rayleigh-Taylor instabilities. In particular, we study how the nature of this process depends on the Reynolds number, the Bond number, and the inclination of the submerged heated plate. In addition we extend the analysis to the case of a submerged heated sphere. Modelling of the transient dynamics of such films is important for answering practical questions such as how instabilities affect the overall heat transfer, and whether they can lead to complete film boiling collapse (Leidenfrost point). This work has been financed under the MAROFF program. We acknowledge the Research Council of Norway (244076/O80) and The Gas Technology Centre NTNU-SINTEF (GTS) for support.

  18. Evaluation of primary stability of inclined orthodontic mini-implants.

    Science.gov (United States)

    Inaba, Mizuki

    2009-09-01

    The aim of this study was to investigate the initial stability of mini-implants when placed slanting or perpendicular to the bone surface, and to examine the effects of differences in tractional direction. Titanium mini-implants were inserted into rabbit nasal bones, slanting (60 degrees , 120 degrees ) or perpendicular (90 degrees ) to the bone surface. These implants were then loaded with a force of approximately 2 N, using a NiTi coil spring. The mobilities on the traction and non-traction sides were assessed using the Periotest device immediately after placement and after traction for two weeks. Then, the tissues with the mini-implants were resected, and the contact between the bone and the implant was examined by electron microscopy. There was a tendency for the mobilities of the mini-implants at 60 degrees and 120 degrees to be smaller than those at 90 degrees when measured before and after traction. The bone-implant contact lengths at 60 degrees were significantly longer than those at 90 degrees . There was no significant difference in the bone-implant contact ratio among the different angles. Correlations were evident between implant mobility and contact length or contact ratio. It is concluded that in clinical practice, implants inclined to the bone surface tend to have better primary stability.

  19. Fluorescence intensity dependence on the propagation plane inclination

    International Nuclear Information System (INIS)

    Fernandez, J.E.; Rubio, Marcelo; Sanchez, H. J.

    1987-01-01

    An experimental confirmation of the fluorescence intensity behaviour with the inclination of the propagation plane (α angle) was carried out. A special angular sample-holder was developed and set up on our X-ray spectrometer. This sample-holder allows different positions of irradiation of the sample modifying the α angle until the maximum angle (α Μ ) is reached in the limit situation. In this work, this maximum angle was 86 deg and the incidence and take off angles were both 45 deg. The sample-holder and the collimation system were carefully lined up. The fluorescent spectra of three National Bureau of Standards (NBS) standard samples were taken for sixteen different α angle positions. The theoretical scheme for both enhanced fluorescent lines and nonenhanced fluorescent lines was confirmed, i.e. the invariance of the primary intensity with the α angle and the decline of the enhanced fluorescence intensities under the same conditions. This experimental confirmation agrees with theoretical prediction: the vanishing of the secondary fluorescence in the extreme case α = π/2. (Author) [es

  20. Revealing strong bias in common measures of galaxy properties using new inclination-independent structures

    Science.gov (United States)

    Devour, Brian M.; Bell, Eric F.

    2017-06-01

    Accurate measurement of galaxy structures is a prerequisite for quantitative investigation of galaxy properties or evolution. Yet, the impact of galaxy inclination and dust on commonly used metrics of galaxy structure is poorly quantified. We use infrared data sets to select inclination-independent samples of disc and flattened elliptical galaxies. These samples show strong variation in Sérsic index, concentration and half-light radii with inclination. We develop novel inclination-independent galaxy structures by collapsing the light distribution in the near-infrared on to the major axis, yielding inclination-independent 'linear' measures of size and concentration. With these new metrics we select a sample of Milky Way analogue galaxies with similar stellar masses, star formation rates, sizes and concentrations. Optical luminosities, light distributions and spectral properties are all found to vary strongly with inclination: When inclining to edge-on, r-band luminosities dim by >1 magnitude, sizes decrease by a factor of 2, 'dust-corrected' estimates of star formation rate drop threefold, metallicities decrease by 0.1 dex and edge-on galaxies are half as likely to be classified as star forming. These systematic effects should be accounted for in analyses of galaxy properties.

  1. Influence of Cusp Inclination and Type of Retention on Fracture Load of Implant-Supported Crowns.

    Science.gov (United States)

    Rocha, Cibele Oliveira de Melo; Longhini, Diogo; Pereira, Rodrigo de Paula; Arioli, João Neudenir

    2017-01-01

    There are few informations about the influence of cusp inclination on the fracture strength of implant-supported crowns. The study aimed to evaluate the influence of cusp inclination and retention type on fracture load in implant-supported metal-ceramic single crowns. Sixty crowns were made, classified as cemented and screw-retained with screw access hole (SAH) sealed or not. Standard (33°) and reduced (20°) cusp inclinations were tested for each group (n=10). To support crowns of a mandibular second molar, analogs of external hexagon implants 5.0 were used. The fracture load was measured in a universal testing machine EMIC DL2000 (10 kN load cell; 0.5 mm/min). Two-way ANOVA (retention and cusp inclination) followed by post hoc Tukey's honest significant difference test was used for the statistical analyses (a=0.05). Crowns with reduced cusp inclination exhibited significantly higher fracture load (pcrowns with standard cusp inclination. Cemented crowns showed significantly higher fracture load (pcrowns. The interaction among these factors was not significant (p>0.05) for the fracture load. The sealing of SAH did not influence the fracture load of screw-retained crowns (p>0.05). In conclusion, fracture load of implant-supported metal-ceramic crowns was influenced by retention and cusp inclination, and there was no influence of the sealing of SAH.

  2. Influence of dental chair backrest inclination on the registration of the mandibular position.

    Science.gov (United States)

    Coelho, Mariana Freire; Cavalcanti, Bruno das Neves; Claro Neves, Ana Christina; Jóias, Renata Pilli; Rode, Sigmar de Mello

    2015-11-01

    Varying the inclination of the dental chair backrest might alter the distribution of occlusal contact points. The purpose of this study was to identify the influence of backrest inclination on the registration of the mandibular position. Ten participants aged between 18 and 30 years with a complete permanent dentition, uncompromised motor function, no tooth mobility, and no temporomandibular disorders were selected. To register interocclusal contacts, an autopolymerizing methylmethacrylate device was adapted to the maxillary anterior teeth and a composite resin increment was added to the mandibular central incisors. Contacts were registered with the following variations in the inclination of the dental chair backrest: 90 degrees, 120 degrees, and 180 degrees. A standardized digital photograph was made of each mark in each backrest position, and the images were superimposed to measure the distances in registration from 90 to 120 and from 90 to 180 degrees. Data were analyzed with the Student paired t test (α=.05). When the chair was inclined from the 90-degree to the 120-degree position, the mandible was repositioned posteriorly by a mean of 0.67 mm, but the difference was not statistically significant. When the chair was inclined from the 90-degree to the 180-degree position, however, the mandible was repositioned posteriorly by a statistically significant mean of 1.41 mm. Mandibular position is influenced by increasing inclination, and this influence was statistically significant at a 180-degree incline. Copyright © 2015 Editorial Council for the Journal of Prosthetic Dentistry. Published by Elsevier Inc. All rights reserved.

  3. Treating domestic sewage by Integrated Inclined-Plate-Membrane bio-reactor

    Science.gov (United States)

    Song, Li Ming; Wang, Zi; Chen, Lei; Zhong, Min; Dong, Zhan Feng

    2017-12-01

    Membrane fouling shorten the service life of the membrane and increases aeration rate for membrane surface cleaning. Two membrane bio-reactors, one for working and another for comparing, were set up to evaluate the feasibility of alleviating membrane fouling and improving wastewater treatment efficiency by integrating inclined-plate precipitation and membrane separation. The result show that: (1) Inclined-plate in reactor had a good effect on pollutant removal of membrane bioreactor. The main role of inclined-plate is dividing reactor space and accelerating precipitation. (2) Working reactor have better performance in COD, TN and TP removal, which can attribute to that working reactor (integrated inclined-plate-Membrane bioreactor) takes both advantages of membrane separation and biological treatment. When influent COD, TP and TN concentration is 163-248 mg/L, 2.08-2.81 mg/L and 24.38-30.49 mg/L in working reactor, effluent concentration is 27-35 mg/L, 0.53-0.59 mg/L and 11.28-11.56 mg/L, respectively. (3) Membrane fouling was well alleviated in integrated inclined-plate-Membrane bioreactor, and membrane normal service time is significantly longer than that in comparing reactor, which can attribute to accelerating precipitation of inclined-plate. In summary, integrated inclined-plate-Membrane bioreactor is a promising technology to alleviating membrane fouling and improving wastewater treatment efficiency, having good performance and bright future in application.

  4. The effect of an inclined landing surface on biomechanical variables during a jumping task.

    Science.gov (United States)

    Hagins, Marshall; Pappas, Evangelos; Kremenic, Ian; Orishimo, Karl F; Rundle, Andrew

    2007-11-01

    Professional dancers sustain a high number of injuries. Epidemiological studies have suggested that performing on inclined "raked" stages increases the likelihood of injury. However, no studies have examined if biomechanical differences exist between inclined and flat surfaces during functional tasks, such as landing from a jump. Such differences may provide a biomechanical rationale for differences in injury risk for raked stages. Eight professional dancers performed drop jumps from a 40cm platform on flat and inclined surfaces while forces, lower extremity kinematics, and electromyographic activity were collected in a controlled laboratory environment. Dancers landed on the laterally inclined surface with significantly higher knee valgus (4 degrees ), peak knee flexion (9 degrees ), and medial-lateral ground reaction force (GRF) (13.4% body weight) compared to the flat condition. The posterior GRF was higher in the anterior inclined condition compared to the flat condition. In the anterior inclined condition, subjects landed with 1.4 degrees higher knee valgus, 4 degrees more plantarflexion at initial contact, and 3 degrees less dorsiflexion at the end of landing. Biomechanical variables that have been suggested to contribute to injury in previous studies are increased in the inclined floor conditions. These findings provide a preliminary biomechanical rationale for differences in injury rates found in observational studies of raked stages.

  5. Multi-layer film flow down an inclined plane: experimental investigation

    KAUST Repository

    Henry, Daniel

    2014-11-19

    We report the results from an experimental study of the flow of a film down an inclined plane where the film itself is comprised of up to three layers of different liquids. By measuring the total film thickness for a broad range of parameters including flow rates and liquid physical properties, we provide a thorough and systematic test of the single-layer approximation for multi-layer films for Reynolds numbers Re = ρQ/μ≈0.03-60. In addition, we also measure the change in film thickness of individual layers as a function of flow rates for a variety of experimental configurations. With the aid of high-speed particle tracking, we derive the velocity fields and free-surface velocities to compare to the single-layer approximation. Furthermore, we provide experimental evidence of small capillary ridge formations close to the point where two layers merge and compare our experimental parameter range for the occurrence of this phenomenon to those previously reported.

  6. Measurement of ambient dose equivalent H*(10) and directional dose equivalent H'(0.07) with pocket sized survey meters

    International Nuclear Information System (INIS)

    Iwatschenko, Michael

    2008-01-01

    Full text: In many parts of the world, predominantly in Europe, small sized survey meters based on Geiger-Mueller or proportional counters are widely used for dose rate and dose equivalent rate measurements, while in other regions, especially in the U.S., ionisation chambers are preferred for this task. This paper tries to shed some light on the likely reasons for these two diverging instrumental inclinations. Their respective strengths and weaknesses is analyzed in respect to energy response, dose rate measuring range, size, weight and susceptibility to environmental influences. Furthermore the response and limitations regarding the measurement of pulsed radiation (medical X-ray and CT-devices, accelerators, non-destructive testing) is discussed. A newly developed pocket size instrument based on a pan-cake Geiger-Mueller tube is used as an example to explain the capability and flexibility of modern survey meters. The RadEye B20 is a compact multi-purpose dose rate meter and contamination meter for alpha, beta, gamma and X-ray radiation. By virtue of carefully designed multi-layer gamma energy filters, H*(10) (deep dose) or H'(0,07) (shallow dose) measurements from 17 - 1300 keV can be performed. The instrument can even be worn in a belt holster, so that the impact to the mobility of the user is minimized. For emergency response purposes alpha and beta contamination can be discriminated using another optional filter; a simple sample changer adapter can extend the scope of application. Immediate and reproducible counter measurements, e.g. of smear tests can be performed locally. (author)

  7. Effects of an inclined walking surface and balance abilities on spatiotemporal gait parameters of older adults.

    Science.gov (United States)

    Ferraro, Richard A; Pinto-Zipp, Genevieve; Simpkins, Susan; Clark, MaryAnn

    2013-01-01

    To date, few studies have investigated how walking patterns on inclines change in healthy older adults. The purpose of the study was to examine the effects of an inclined walking surface and balance abilities on various spatiotemporal gait parameters of healthy older adults. Seventy-eight self-reported independent community ambulators (mean age, 77.8 years; SD, 4.8) participated in this study. After completing the Berg Balance Scale and Dynamic Gait Index (DGI), all participants were asked to walk on the GaitRite on level and inclined surfaces (10° slope). Dependent t tests were used to determine statistical significance between level and inclined surfaces for cadence, step length, velocity, and gait stability ratio (GSR). GSR is a measure of the degree of adaptation an individual makes to increase stability during gait derived from a ratio of cadence/velocity. A 2 2 analysis of variance was performed to determine differences in means among the higher-risk participants (as determined by the Berg Balance Scale and Dynamic Gait Index) comparing their level and incline walking patterns. The level of significance was set at P 0.05. During incline walking a significant decrease occurred in mean step length, 63.1(8.8) cm, P 0.001, mean cadence, 111.6 (8.9) step/min, P 0.01 and mean normalized velocity, 1.4 (0.23), P 0.001. However, mean GSR increased on inclines, 1.62 (0.22) steps/m, P 0.004. Main effects were evident for both walking surface and fall risk for all gait parameters tested. Healthy older adults adopt a more stable gait pattern on inclines decreasing velocity and spending more time in the double support despite the increased physiological demands to perform this task. Clear changes were evident between level and incline surfaces regardless of fall risk as defined by 2 different objective balance measures [corrected].

  8. Comparison of the buccolingual inclination in alveolar bone and tooth using dental CBCT

    International Nuclear Information System (INIS)

    Kim, Sung Eun; Kim, Jin Soo; Kim, Jae Duk

    2008-01-01

    It is important to determine the bucco-lingual inclination of implants on radiographs before the implant surgery. The purpose of this study was to compare the buccolingual inclination in alveolar bone and the tooth with dental cone beam CT and to prepare the standard for the buccolingual inclination of implant. Axial, panoramic, and buccolingually sectioned images of 80 implant cases with stent including straight marker using CB Mercuray TM (Hitachi, Japan) were evaluated. The comparison of the buccolingual inclination of remained alveolar bone with the tooth and the marker on buccolingually sectioned views was performed statistically. The average buccolingual inclination of remained alveolar bone and tooth was 82.8 ± 4.6 .deg. C and 85.8 ± 4.7 .deg. C (p 0.05, r=0.12) at the 2nd premolar area in upper jaw. The average buccolingual inclination of remained alveolar bone and tooth was 81.3 ± 8.3 .deg. C and 87.5 ± 6.3 .deg. C (p>0.05, r=0.85) at the lower 2nd premolar area and 94.3 ± 6.6 .deg. C and 93.3 ± 7.2 .deg. C respectively (p>0.05, r=0.91) at the 1st molar area in lower jaw. The inclinations of markers were very different from those of remained bone at the most of areas except the upper 2nd premolar area (r=0.79). We recommend dental CBCT analysis for determining the buccolingual inclination of dental implant, because of significant difference, in average, between the buccolingual inclination of remained alveolar bone and tooth.

  9. Methotrexate Dosing Regimen for Plaque-type Psoriasis : A Systematic Review of the Use of Test-dose, Start-dose, Dosing Scheme, Dose Adjustments, Maximum Dose and Folic Acid Supplementation

    NARCIS (Netherlands)

    Menting, Stef P; Dekker, Paul M; Limpens, Jacqueline; Hooft, Lotty; Spuls, Phyllis I

    2016-01-01

    There is a range of methotrexate dosing regimens for psoriasis. This review summarizes the evidence for test-dose, start-dose, dosing scheme, dose adjustments, maximum dose and use of folic acid. A literature search for randomized controlled trials and guidelines was performed. Twenty-three

  10. Methotrexate Dosing Regimen for Plaque-type Psoriasis: A Systematic Review of the Use of Test-dose, Start-dose, Dosing Scheme, Dose Adjustments, Maximum Dose and Folic Acid Supplementation

    NARCIS (Netherlands)

    Menting, Stef P.; Dekker, Paul M.; Limpens, Jacqueline; Hooft, Lotty; Spuls, Phyllis I.

    2016-01-01

    There is a range of methotrexate dosing regimens for psoriasis. This review summarizes the evidence for test-dose, start-dose, dosing scheme, dose adjustments, maximum dose and use of folic acid. A literature search for randomized controlled trials and guidelines was performed. Twenty-three

  11. Natural Convection in an Inclined Porous Cavity with Spatial Sidewall Temperature Variations

    Directory of Open Access Journals (Sweden)

    M. S. Selamat

    2012-01-01

    Full Text Available The natural convection in an inclined porous square cavity is investigated numerically. The left wall is assumed to have spatial sinusoidal temperature variations about a constant mean value, while the right wall is cooled. The horizontal walls are considered adiabatic. A finite difference method is used to solve numerically the nondimensional governing equations. The effects of the inclination angle of the cavity, the amplitude and wave numbers of the heated sidewall temperature variation on the natural convection in the cavity are studied. The maximum average Nusselt number occurs at different wave number. It also found that the inclination could influence the Nusselt number.

  12. Effect of wall inclination on natural convection in a porous trapezoidal cavity

    Science.gov (United States)

    Cheong, H. T.; Sivasankaran, S.; Siri, Z.

    2014-07-01

    The present study investigates numerically the effect of wall inclination of a trapezoidal cavity on natural convective flow and heat transfer. The cavity is filled with porous medium. Sinusoidal temperature is applied on the inclined wall and the opposite wall is maintained at a constant temperature. The top and bottom walls are adiabatic. The Darcy model is adopted for porous medium. The governing equations are solved using the finite difference method with various values of wall inclination and Rayleigh number. The heat transfer of the square cavity is found to be higher than that of trapezoidal and triangular cavities.

  13. The metabolic cost of walking on an incline in the Peacock (Pavo cristatus)

    OpenAIRE

    Wilkinson, Holly; Thavarajah, Nathan; Codd, Jonathan

    2015-01-01

    Altering speed and moving on a gradient can affect an animal’s posture and gait, which in turn can change the energetic requirements of terrestrial locomotion. Here, the energetic and kinematic effects of locomoting on an incline were investigated in the Indian peacock, Pavo cristatus. The mass-specific metabolic rate of the Indian peacock was elevated on an incline, but this change was not dependent on the angle ascended and the cost of lifting remained similar between the two inclines (+5 a...

  14. Inclination shallowing in the Eocene Linzizong sediments from Tibet: correction, possible causes and implications for reconstructing the India-Asia collision

    NARCIS (Netherlands)

    Huang, W.; Dupont-Nivet, G.; Lippert, P.C.; Hinsbergen, D.J.J. van; Hallot, E.

    2013-01-01

    A systematic bias towards low palaeomagnetic inclination recorded in clastic sediments, that is, inclination shallowing, has been recognized and studied for decades. Identification, understanding and correction of this inclination shallowing are critical for palaeogeographic

  15. Study on ex-vessel cooling of RPV (behavior of coalesced bubbles and trigger condition of critical heat flux on inclined plate)

    International Nuclear Information System (INIS)

    Ohtake, H.; Koizumi, Y.; Takano, K.I.

    2001-01-01

    The Ex-vessel cooling of Reactor-Pressure-Vessel in Light-Water-Reactor at the severe accident have been proposed for future nuclear reactors. The estimation of Critical-Heat-Flux on a downward-facing curvilinear surface, like a hemisphere, is important to the assessment of the cooling. In this study, the CHFs on inclined surfaces were examined experimentally focusing on orientation of the heating surface. In order to discuss detailed mechanism of the CHF, the behaviors of coalesced bubbles near the heating surface were investigated through visual observations. The critical heat flux obtained in the present experiments increased with the inclined angle over the present experimental range. The dependence of the inclined angle on the critical heat flux was q CHF,R-113 [q] = f (q 0.33 ) for the present experimental results. The effect of the surface orientation on the critical heat flux was roughly explained by using the simple analytical model based on the macro-layer model and Kelvin-Helmholtz instability. From visual observations for behavior of bubbles near the heating surface, whereas the coalesced bubble covered over the heating surface for the inclined angle of 0 degree, the coalesced bubble moved upward to avoid packing the bubble on the surface above 5 degree. As the inclined angle increased, the velocity of the coalesced bubble was high, the period covered the heater and the bubble length were small. The results suggested that the CHF was closely related to forming the coalesced bubble and the behavior of the bubble. (author)

  16. Beam Shear Design According to Eurocode 2 - Limitations for the Concrete Strut Inclinations

    DEFF Research Database (Denmark)

    Hagsten, Lars German; Hestbech, Lars; Fisker, Jakob

    2011-01-01

    and are presented. These beams are all designed to fail in shear and the shear reinforcement is designed for different values of the concrete strut inclinations (cot θ varies from 1.5 to 3.4). These tests indicate a clear connection between the values of the concrete strut inclinations and crack width in the SLS......The beam shear design method adopted in Eurocode 2 is based on a lower bound plastic solution. This method is combined with limitations on the concrete strut inclination, θ. These limitations are introduced to ensure acceptable crack width in the SLS. 7 full scale beams have been tested....... In cases where larger crack widths (w > 0.4 mm) can be accepted, larger values of the concrete strut inclinations can be chosen. This will lead to less shear reinforcements. The results are also compared with analytical analysis based on energy methods. At the SLS the beams are expected to be cracked...

  17. Muscular activity of lower limb muscles associated with working on inclined surfaces.

    Science.gov (United States)

    Lu, Ming-Lun; Kincl, Laurel; Lowe, Brian; Succop, Paul; Bhattacharya, Amit

    2015-01-01

    This study investigated the effects of visual cues, muscular fatigue, task performance and experience of working on inclined surfaces on activity of postural muscles in the lower limbs associated with maintaining balance on three inclined surfaces - 0°, 14° and 26°. Normalised electromyographic (NEMG) data were collected in 44 professional roofers bilaterally from the rectus femoris, biceps femoris, tibialii anterior and gastrocnemii medial muscle groups. The 50th and 95th percentile NEMG amplitudes were used as EMG variables. Results showed that inclination angle and task performance caused a significant increase in the NEMG amplitudes of all postural muscles. Visual cues were significantly associated with a decrease in the 95th percentile EMG amplitude for the right gastrocnemius medial and tibialis anterior. Fatigue was related to a significant decrease in the NEMG amplitude for the rectus femoris. Experience of working on inclined surfaces did not have a significant effect on the NEMG amplitude.

  18. Incisor inclination determined by the light reflection zone on the tooth's surface.

    Science.gov (United States)

    Brezniak, Naphtali; Turgeman, Ronit; Redlich, Meir

    2010-01-01

    Maxillary incisors are the most prominent teeth, and their inclination plays an important role in esthetics. In orthodontics, the inclination of central incisors is usually determined by cephalometric analysis. This publication suggests an adjunctive clinical measure to determine this inclination. The objective of the study was to examine the correlation between the inclinations of maxillary incisors measured on a cephalometric lateral headfilm and the light reflection zone appearing on the buccal surface of the teeth on anterior intraoral photographs. Maxillary incisor inclination, divided into three levels-proclination, normal inclination, and retroclination-of 65 patients was determined by means of cephalometric analysis, using three angular measurements (maxillary incisor to sella-nasion, maxillary incisor to Frankfort horizontal, and maxillary incisor to nasion-point A). The anterior intraoral photographs of the 65 patients were divided into 3 groups according to the reflection zone on the maxillary central incisors as determined from the photographs: incisal, middle, and gingival. The correlation and agreement between the two parameters were evaluated by chi-square and kappa statistics. The light reflection zone on the tooth surface as it appears on intraoral photographs-incisal, middle, or gingival-correlated with statistical significance to the angular inclination of the teeth-proclination, normal inclination, and retroclination, respectively-as determined by means of cephalometric analysis (P light reflection zone viewed on the buccal surface of intraoral photographs. This method might be used as a new screening tool and further as an additional clinical tool for assessing treatment plans in orthodontics and other fields of dentistry.

  19. Natural Convection in an Inclined Porous Cavity with Spatial Sidewall Temperature Variations

    OpenAIRE

    Selamat, M. S.; Roslan, R.; Hashim, I.

    2012-01-01

    The natural convection in an inclined porous square cavity is investigated numerically. The left wall is assumed to have spatial sinusoidal temperature variations about a constant mean value, while the right wall is cooled. The horizontal walls are considered adiabatic. A finite difference method is used to solve numerically the nondimensional governing equations. The effects of the inclination angle of the cavity, the amplitude and wave numbers of the heated sidewall temperature variation o...

  20. The effect of speleothem surface slope on the remanent magnetic inclination

    Science.gov (United States)

    Ponte, J. M.; Font, E.; Veiga-Pires, C.; Hillaire-Marcel, C.; Ghaleb, B.

    2017-06-01

    Speleothems are of interest for high-resolution reconstruction of the Earth's magnetic field. However, little is known about the influence of speleothem morphologies on their natural remanent magnetization (NRM) record. Here we report on a high-resolution paleomagnetic study of a dome-shaped speleothem of middle Holocene age from southern Portugal, with special attention to the anisotropy of magnetic susceptibility (AMS) and anisotropy of anhysteretic remanent magnetization (AARM). To assess the potential influence of the slope of the speleothem surface on the recorded remanent magnetization, we compare magnetic directions and AMS and AARM fabrics from subhorizontal to gradually subvertical calcite growth layers collected in a transversal cross section of the speleothem. A linear correlation is observed between magnetic inclinations, calcite laminae slope, and AARM k1 inclination. The AMS fabric is mostly controlled by calcite crystals, with direction of the minimum axes (k3) perpendicular to laminae growth. Magnetic inclinations recorded in inclined and vertical calcite growth layers are underestimated when compared to a global paleosecular variation (PSV) model. After extrapolating magnetic inclinations to the horizontal, the corrected data better fit the PSV model but are still lower than the predicted magnetic inclinations, suggesting that inclination shallowing affects the entire speleothem. We suggest that speleothem morphology exerts a critical role on the magnetic inclination recording, which is controlled by the Earth's magnetic field but also influenced by particle rolling along the sloping surfaces. These observations open new avenues for reconstructing high-resolution paleomagnetic secular variation records from speleothems and provide new insights into their NRM acquisition mechanisms.

  1. Characterization of Dose in a TC of 64-Detectors used in pediatrics. Evaluation of the effects of the Over beaming and Over ranging; Caracterizacion de dosis en un TC de 64 detectores utilizado en pediatria. Evaluacion de los efectos del Overbeaming y Overranging

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Castanon, P.; Roch Gonzalez, M.; Rodriguez Martin, G.; Espana Lopez, M. L.; Giner Sala, M.

    2013-07-01

    The objective of this study is to evaluate the contribution of effects over beaming and over ranging dose received by the patient in a TC multislice with 64 detectors, installed at a children's hospital, for the different acquisition modes available, in order to assess the adequacy of the protocols pre-set for Pediatrics and more accurately assess the received dose. (Author)

  2. Digital holography on moving objects: multiwavelength height measurements on inclined surfaces

    Science.gov (United States)

    Schiller, Annelie; Beckmann, Tobias; Fratz, Markus; Belzer, Dominik; Bertz, Alexander; Carl, Daniel; Buse, Karsten

    2017-06-01

    Multiwavelength digital holography on moving objects enables fast and precise inline-measurements of surface pro files. Due to the use of multiple wavelengths, optically rough surfaces with structure heights in the micrometer range can be mapped unambiguously. In this work we explore the influence of the object velocity on height measurements on inclined surfaces. We show measurements using spatial-phase-shifting holography employing two wavelengths and object velocities of up to 90 mm/s with eye-safe cw-lasers with less than 1 mW of laser light. Despite motion blur exceeding the mean speckle size, reliable height measurements can be conducted at these velocities. The height map of a metal cone with two different slope angles (1° , 10° ) is measured at an exposure time of 2 ms. Using line shaped illumination, each frame yields a height map of approximately 2 x 17 mm2. The overlap between the frames allows averaging as the image is put together, improving data quality. The mean repeatability of the height information in the investigated setup is better than 4.5 µm at a synthetic wavelength of 214 µm.

  3. INCLINATION TO VICTIMALITY AND HIGH SCHOOL PUPILS’ VIEW OF A SAFE-TYPE PERSON: PSYCHOLOGICAL ANALYSIS

    Directory of Open Access Journals (Sweden)

    Irina Ivanovna Patsakula

    2017-11-01

    Full Text Available Purpose. The article is dedicated to the urgent subject: formation of healthy, actively creating and socially adapted person in the environment of social and economic changes, and also to the increasing demand in victimology prevention and correction. The authors aim to study the link between a person’s victim behaviour and a young generation’s view of the identity of a safe type. Method and methodology of the work. The research is based on the methods of psychosemantics (association experiment, specialised semantic differential [2], research methodology of inclination to victim behaviour by O.O. Andronikova [1], math statistics: coefficient of range correlation by R.S. Spirman. Results. The article presents the results of investigating a person’s victim behaviour in the connection with the idea of the identity of a safe type. The research of the representatives of a young generation was made, which proved that the teenagers having and the teenagers not having in their behaviour victim characteristics differ in their views of a safe-type person by the emotional component, by the extent of different characteristics and by the contents of associations. The sphere of applying the results. The results can by used in pedagogics, psychology, and law in the context o victimology prevention.

  4. DRYING PERFORMANCE AND OVERALL ENERGY REQUISITE OF INDUSTRIAL INCLINED BED PADDY DRYING IN MALAYSIA

    Directory of Open Access Journals (Sweden)

    M. NORDIN IBRAHIM

    2014-06-01

    Full Text Available An attempt was undertaken to evaluate the performance of industrial inclined bed dryers (IBDs in terms of drying capacity, drying rate, overall energy requisite and final quality of dried product in drying of freshly harvested paddy. In drying of paddy with initial moisture content of 22-23% wet basis (wb to around 12.5% (wb final moisture content, drying capacity and drying rate of the dryers were found to vary between 0.66 to 1.03 ton dry paddy/hour and 90 to 121 kg moisture/hour, respectively, for the holding capacity of each dryer at about 15 ton. The electrical energy consumption of the IBDs was found to vary between 18.15 to 27.55 kWh/t while the thermal energy consumption ranged between 960 to 1328.15 MJ/t. The IBDs operated at air temperature of 38-39oC yielded 1 to 4% higher head rice yield than the IBDs were operated at 41-42oC for drying of similar moist paddy, but milling recovery and whiteness were comparable.

  5. Numerical simulation and structural optimization of the inclined oil/water separator.

    Directory of Open Access Journals (Sweden)

    Liqiong Chen

    Full Text Available Improving the separation efficiency of the inclined oil/water separator, a new type of gravity separation equipment, is of great importance. In order to obtain a comprehensive understanding of the internal flow field of the separation process of oil and water within this separator, a numerical simulation based on Euler multiphase flow analysis and the realizable k-ε two equation turbulence model was executed using Fluent software. The optimal value ranges of the separator's various structural parameters used in the numerical simulation were selected through orthogonal array experiments. A field experiment on the separator was conducted with optimized structural parameters in order to validate the reliability of the numerical simulation results. The research results indicated that the horizontal position of the dispenser, the hole number, and the diameter had significant effects on the oil/water separation efficiency, and that the longitudinal position of the dispenser and the position of the weir plate had insignificant effects on the oil/water separation efficiency. The optimal structural parameters obtained through the orthogonal array experiments resulted in an oil/water separation efficiency of up to 95%, which was 4.996% greater than that realized by the original structural parameters.

  6. Laser-Guided Autonomous Landing of a Quadrotor UAV on an Inclined Surface

    Science.gov (United States)

    Dougherty, John A.

    This thesis presents measurement, estimation, and control schemes to aid a quadrotor unmanned aerial vehicle (UAV) in landing on a flat, inclined surface without prior knowledge of the surface's inclination. The system uses a single CMOS camera and several inexpensive laser modules for onboard sensing to measure the distance to and orientation of a landing surface. A nonlinear least squares estimation scheme yields the altitude of the quadrotor and the normal vector defining the ground plane. This information is used to design a hybrid landing trajectory composed of a position tracking phase and an attitude tracking phase. A geometric nonlinear control system is used during each phase and ensures that the quadrotor's attitude is aligned to the inclination of the ground surface at touchdown. A quadrotor is developed from the ground up to test the in-flight measurement process and to execute landing trajectories on an inclined surface. Experimental results demonstrate the quadrotor's ability to accurately estimate altitude and ground plane orientation during flight, and numerical simulations of landing trajectories for various surface inclinations are validated by experimental results up to a maximum inclination of thirty degrees.

  7. Development of an Inclined Plate Extractor-Separator for Immiscible Liquids

    Directory of Open Access Journals (Sweden)

    Syed Zahoor ul Hassan Rizvi

    2009-10-01

    Full Text Available A new inclined plates extractor-separator is developed for operation with immiscible liquids in which extraction and separation is achieved in one unit contrary to mixer settlers. The inclined plates extractor-separator combines turbulent jets for contacting, and an inclined plate for separation of the two phases. The inclined plates extractor-separator does not have any moving part inside the vessel. This feature makes it free from the mechanical problems associated with conventional apparatus. The proposed inclined plates extractor-separator was operated in batch mode under various operating conditions to evaluate its performance on the basis of extraction efficiency. Water (light phase was used as solvent to extract ethyl acetate from a heavy phase pool of tetrachloroethylene and ethyl acetate. The ethyl acetate content was analysed using chromatography. A hydrodynamic study was carried out using high speed photography to understand the mechanisms occurring during mass transfer across the two phases. Furthermore, it was found that the proposed inclined plate extractor-separator reduces the overall operating time by 67% and consumes only 13% of the power in comparison to a mixer-settler. A hydraulic power consumption comparison with a mixer settler and a gullwing extractor-separator is also presented.

  8. An inclined plane system with microcontroller to determine limb motor function of laboratory animals.

    Science.gov (United States)

    Chang, Ming-Wen; Young, Ming-Shing; Lin, Mao-Tsun

    2008-02-15

    This study describes a high-accuracy inclined plane test system for quantitative measurement of the limb motor function of laboratory rats. The system is built around a microcontroller and uses a stepping motor to drive a ball screw, which changes the angle of the inclined plane. Any of the seven inclination speeds can be selected by the user. Two infrared (IR) LED/detector pairs function as interrupt sensors for objective determination of the moment that the rat loses its grip on the textured flooring of the starting area and slips down the plane. Inclination angle at the moment of IR interrupt (i.e. rat slip) is recorded. A liquid crystal display module shows the inclination speed and the inclination angle. The system can function as a stand alone device but a RS232 port allows connection to a personal computer (PC), so data can be sent directly to hard disk for storage and analysis. Experiments can be controlled by a local keypad or by the connected PC. Advantages of the presented system include easy operation, high accuracy, non-dependence on human observation for determination of slip angle, stand-alone capability, low cost and easy modification of the controlling software for different types of experiments. A fully functional prototype of the system is described. The prototype was used experimentally by a hospital group testing traumatic brain injury experiments, and some of their results are presented for system verification. It is found that the system is stable, accurate and easily used by investigators.

  9. Interfacial friction factors for air-water co-current stratified flow in inclined channels

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ki Yong; No, Hee Cheon [Korea Advanced Institute of Science and Technology, Taejon (Korea, Republic of)

    1997-12-31

    The interfacial shear stress is experimentally investigated for co-current air-water stratified flow in inclined rectangular channels having a length of 1854mm, width of 120 mm and height of 40mm at almost atmospheric pressure. Experiments are carried out in several inclinations from 0 deg up to 10 deg. The local film thickness and the wave height are measured at three locations, i.e., L/H = 8,23, and 40. According to the inclination angle, the experimental data are categorized into two groups; nearly horizontal data group (0 deg {<=} {theta} {<=} 0.7 deg), and inclined channel data group (0.7 deg {<=} {theta} {<=} 10 deg ). Experimental observations for nearly horizontal data group show that the flow is not fully developed due to the water level gradient and the hydraulic jump within the channel. For the inclined channel data group, a dimensionless wave height, {Delta}h/h, is empirically correlated in terms of Re{sub G} and h/H. A modified root-mean-square wave height is proposed to consider the effects of the interfacial and wave propagation velocities. It is found that an equivalent roughness has a linear relationship with the modified root-mean-square wave height and its relationship is independent of the inclination. 10 refs., 6 figs., 1 tab. (Author)

  10. Effect of clear aligner therapy on the buccolingual inclination of mandibular canines and the intercanine distance.

    Science.gov (United States)

    Grünheid, Thorsten; Gaalaas, Sara; Hamdan, Hani; Larson, Brent E

    2016-01-01

    To compare the changes in buccolinugal inclination of mandibular canines and intercanine distance in patients treated with clear aligners to those treated with preadjusted edgewise appliances. The buccolingual inclination of mandibular canines and the intercanine distance were measured on pre- and posttreatment cone-beam computed tomograms of 30 patients who had been treated with clear aligners and 30 patients who had been treated with fixed preadjusted edgewise appliances. Differences between the aligner and fixed appliance groups and between pre- and posttreatment measurements were tested for statistical significance. In both groups, most of the mandibular canines had positive buccolingual inclinations (ie, their crowns were positioned lateral to their roots) both before and after treatment. While there was no difference between the groups pretreatment, the posttreatment buccolingual inclination was significantly greater in the aligner group. In the fixed appliance group, the canines became more upright with treatment, while the buccolingual inclination did not change significantly in the clear aligner group. The intercanine distance did not differ between the groups either before or after treatment. However, it increased significantly over the course of treatment in the aligner group, whereas it did not change significantly in the fixed appliance group. Orthodontic treatment with clear aligners tends to increase the mandibular intercanine distance with little change in inclination in contrast to treatment with fixed appliances, which leaves the intercanine distance unchanged but leads to more upright mandibular canines.

  11. Effects of occlusal inclination and loading on mandibular bone remodeling: a finite element study.

    Science.gov (United States)

    Rungsiyakull, Chaiy; Rungsiyakull, Pimdeun; Li, Qing; Li, Wei; Swain, Michael

    2011-01-01

    To provide a preliminary understanding of the biomechanics with respect to the effect of cusp inclination and occlusal loading on the mandibular bone remodeling. Three different cusp inclinations (0, 10, and 30 degrees) of a ceramic crown and different occlusal loading locations (central fossa and 1- and 2-mm offsets horizontally) were taken into account to explore the stresses and strains transferred from the crown to the surrounding dental bone through the implant. A strain energy density obtained from two-dimensional plane-strain finite element analysis was used as the mechanical stimulus to drive cancellous and cortical bone remodeling in a buccolingual mandibular section. Different ceramic cusp inclinations had a significant effect on bone remodeling responses in terms of the change in the average peri-implant bone density and overall stability. The remodeling rate was relatively high in the first few months of loading and gradually decreased until reaching its equilibrium. A larger cusp inclination and horizontal offset (eg, 30 degrees and 2-mm offset) led to a higher bone remodeling rate and greater interfacial stress. The dental implant superstructure design (in terms of cusp inclination and loading location) determines the load transmission pattern and thus largely affects bone remodeling activities. Although the design with a lower cusp inclination recommended in previous studies may reduce damage and fracture failure, it could, to a certain extent, compromise bone engagement and long-term stability.

  12. The metabolic cost of walking on an incline in the Peacock (Pavo cristatus

    Directory of Open Access Journals (Sweden)

    Holly Wilkinson

    2015-06-01

    Full Text Available Altering speed and moving on a gradient can affect an animal’s posture and gait, which in turn can change the energetic requirements of terrestrial locomotion. Here, the energetic and kinematic effects of locomoting on an incline were investigated in the Indian peacock, Pavo cristatus. The mass-specific metabolic rate of the Indian peacock was elevated on an incline, but this change was not dependent on the angle ascended and the cost of lifting remained similar between the two inclines (+5 and +7°. Interestingly, the Indian peacock had the highest efficiency when compared to any other previously studied avian biped, despite the presence of a large train. Duty factors were higher for birds moving on an incline, but there was no difference between +5 and +7°. Our results highlight the importance of investigating kinematic responses during energetic studies, as these may enable explanation of what is driving the underlying metabolic differences when moving on inclines. Further investigations are required to elucidate the underlying mechanical processes occurring during incline movement.

  13. The metabolic cost of walking on an incline in the Peacock (Pavo cristatus).

    Science.gov (United States)

    Wilkinson, Holly; Thavarajah, Nathan; Codd, Jonathan

    2015-01-01

    Altering speed and moving on a gradient can affect an animal's posture and gait, which in turn can change the energetic requirements of terrestrial locomotion. Here, the energetic and kinematic effects of locomoting on an incline were investigated in the Indian peacock, Pavo cristatus. The mass-specific metabolic rate of the Indian peacock was elevated on an incline, but this change was not dependent on the angle ascended and the cost of lifting remained similar between the two inclines (+5 and +7°). Interestingly, the Indian peacock had the highest efficiency when compared to any other previously studied avian biped, despite the presence of a large train. Duty factors were higher for birds moving on an incline, but there was no difference between +5 and +7°. Our results highlight the importance of investigating kinematic responses during energetic studies, as these may enable explanation of what is driving the underlying metabolic differences when moving on inclines. Further investigations are required to elucidate the underlying mechanical processes occurring during incline movement.

  14. Investigating the heat transfer on the top side of inclined printed circuit boards during vapour phase soldering

    International Nuclear Information System (INIS)

    Illés, Balázs; Géczy, Attila

    2016-01-01

    Highlights: • Investigating the effect of inclination on heat transfer uniformity and intensity during VPS. • Even moderate inclination has high impact on the condensate layer and on the heat transfer. • Inclination under 1° has negative effect on temperature distribution of the soldered board. • Inclination from 1° to 10° improves heat transfer uniformity of vapour phase soldering. • Inclination can help to reduce soldering failures during vapour phase soldering. - Abstract: In this paper, heat transfer and condensate layer formation was investigated by numerical simulations on the top side of inclined printed circuit boards during vapour phase soldering. The phase change on the inclined surface and the transfer mechanisms in the condensate layer were embedded in a three-dimensional model. Steady-state and saturated vapour conditions were applied as boundary conditions in order to study the pure effect of the inclination. Due to the electronic component and circuit board structures during soldering only moderate inclination angles were studied between 0° and 10°. It was found that a moderate inclination of the printed circuit board has considerable effects on the formation of condensate layer and consequently on heat transfer. Compared to the default horizontal orientation of the board, the thickness differences of the condensate layer can be decreased with an optimised inclination of the printed circuit board. This effect homogenizes heat transfer during the process, enabling improved solder joint quality, with reduced overall soldering failure count.

  15. Clinical commissioning of an in vivo range verification system for prostate cancer treatment with anterior and anterior oblique proton beams

    Science.gov (United States)

    Hoesl, M.; Deepak, S.; Moteabbed, M.; Jassens, G.; Orban, J.; Park, Y. K.; Parodi, K.; Bentefour, E. H.; Lu, H. M.

    2016-04-01

    The purpose of this work is the clinical commissioning of a recently developed in vivo range verification system (IRVS) for treatment of prostate cancer by anterior and anterior oblique proton beams. The IRVS is designed to perform a complete workflow for pre-treatment range verification and adjustment. It contains specifically designed dosimetry and electronic hardware and a specific software for workflow control with database connection to the treatment and imaging systems. An essential part of the IRVS system is an array of Si-diode detectors, designed to be mounted to the endorectal water balloon routinely used for prostate immobilization. The diodes can measure dose rate as function of time from which the water equivalent path length (WEPL) and the dose received are extracted. The former is used for pre-treatment beam range verification and correction, if necessary, while the latter is to monitor the dose delivered to patient rectum during the treatment and serves as an additional verification. The entire IRVS workflow was tested for anterior and 30 degree inclined proton beam in both solid water and anthropomorphic pelvic phantoms, with the measured WEPL and rectal doses compared to the treatment plan. Gafchromic films were also used for measurement of the rectal dose and compared to IRVS results. The WEPL measurement accuracy was in the order of 1 mm and after beam range correction, the dose received by the rectal wall were 1.6% and 0.4% from treatment planning, respectively, for the anterior and anterior oblique field. We believe the implementation of IRVS would make the treatment of prostate with anterior proton beams more accurate and reliable.

  16. Investigations of the regulation of cerebral circulation by means of functional changes observed on unanaesthetized rabbits during hypoxia, paradoxical sleep and after whole-body γ-exposure (850-150 rad dose range)

    International Nuclear Information System (INIS)

    Dufour, Raymond.

    1977-01-01

    Both the general effects and the effects on cerebral circulation of whole-body exposure were studied at doses of 850, 650, 450, 250 and 150 rads. Early functional changes following exposure demonstrated two juxtaposed mechanisms, a central one and a peripheral one. The central process, slightly sensitive to the dose-effect, occurred earlier and should be at the origin of hyperthermia, hyperventilation, tachycardia, skin vasoconstruction and a slight increase of arterial pressure. The peripheral mechanisms, occurring slightly later should be more sensitive to the dose-effect and might be at the origin of hypothermic effects and cardiovascular depression. The increase of cerebral blood flow occurring at the 450 rad dose should be best explained by the presence of vasotropic substances. A twofold component of cerebral vasotonicity should be assumed that would depend on the autonomous nervous system and myogenous autoregulation [fr

  17. Measurement of the ultra high energy cosmic ray flux from data of very inclined showers at the Pierre Auger Observatory

    Energy Technology Data Exchange (ETDEWEB)

    Dembinski, Hans Peter

    2009-12-03

    This work describes the derivation of the energy dependent flux of ultra-high energy cosmic rays from data of very inclined air showers observed with the Pierre Auger Observatory. It focuses on the event class of very inclined air showers with zenith angles larger than 60 . The lateral ground profile of these showers is muon dominated and not radially symmetric around the shower axis due to geomagnetic deflections and other effects. The dependency of this profile on the direction, energy and mass of the cosmic ray is discussed with a mixture of detailed Monte-Carlo simulations and a simplified analytical model of the air shower cascade. It is found in agreement with other studies that the normalized shape of the muon density profile is approximately universal over the range of cosmic ray energies and masses measured at the Pierre Auger Observatory, that the amplitude of the profile is almost proportional to the cosmic ray energy, and that its shower-to-shower fluctuations are sensitive to the mass composition of the cosmic rays. (orig.)

  18. Measurement of the ultra high energy cosmic ray flux from data of very inclined showers at the Pierre Auger Observatory

    International Nuclear Information System (INIS)

    Dembinski, Hans Peter

    2009-01-01

    This work describes the derivation of the energy dependent flux of ultra-high energy cosmic rays from data of very inclined air showers observed with the Pierre Auger Observatory. It focuses on the event class of very inclined air showers with zenith angles larger than 60 . The lateral ground profile of these showers is muon dominated and not radially symmetric around the shower axis due to geomagnetic deflections and other effects. The dependency of this profile on the direction, energy and mass of the cosmic ray is discussed with a mixture of detailed Monte-Carlo simulations and a simplified analytical model of the air shower cascade. It is found in agreement with other studies that the normalized shape of the muon density profile is approximately universal over the range of cosmic ray energies and masses measured at the Pierre Auger Observatory, that the amplitude of the profile is almost proportional to the cosmic ray energy, and that its shower-to-shower fluctuations are sensitive to the mass composition of the cosmic rays. (orig.)

  19. Fem Simulation of Triple Diffusive Natural Convection Along Inclined Plate in Porous Medium: Prescribed Surface Heat, Solute and Nanoparticles Flux

    Directory of Open Access Journals (Sweden)

    Goyal M.

    2017-12-01

    Full Text Available In this paper, triple diffusive natural convection under Darcy flow over an inclined plate embedded in a porous medium saturated with a binary base fluid containing nanoparticles and two salts is studied. The model used for the nanofluid is the one which incorporates the effects of Brownian motion and thermophoresis. In addition, the thermal energy equations include regular diffusion and cross-diffusion terms. The vertical surface has the heat, mass and nanoparticle fluxes each prescribed as a power law function of the distance along the wall. The boundary layer equations are transformed into a set of ordinary differential equations with the help of group theory transformations. A wide range of parameter values are chosen to bring out the effect of buoyancy ratio, regular Lewis number and modified Dufour parameters of both salts and nanofluid parameters with varying angle of inclinations. The effects of parameters on the velocity, temperature, solutal and nanoparticles volume fraction profiles, as well as on the important parameters of heat and mass transfer, i.e., the reduced Nusselt, regular and nanofluid Sherwood numbers, are discussed. Such problems find application in extrusion of metals, polymers and ceramics, production of plastic films, insulation of wires and liquid packaging.

  20. Inclination angle effect on natural convection in a square cavity partially filled with non-Newtonian fluids layer

    Science.gov (United States)

    Alsabery, Ammar I.; Hussain, Salam H.; Saleh, Habibis; Hashim, Ishak

    2015-09-01

    The problem of inclination angle effect on natural convection in a square cavity partially filled with non-Newtonian fluid layer is studied numerically using The Finite Volume Method. Governing equations are solved over wide range of Darcy number (10-5 ≤ Da ≤ 10-1), power-law index(0.6 ≤ n ≤ 1.4), the inclination angle of the cavity (0° ≤ ω ≤ 90°), Rayleigh number (Ra = 105) and porous layer thickness (S = 0.5). The results presented for values of the governing parameters in terms of streamlines in both porous/non-Newtonian fluid-layer, isotherms in both porous/non-Newtonian fluid-layer and average Nusselt number. It is shown that the heat transfer has maximum value when the power-law index is less than one (pseudoplastic fluid), and then decreases remarkably as the power-law index increases. The results have possible applications in heat-removal and heat-storage non-Newtonian fluid-saturated porous systems.

  1. Fem Simulation of Triple Diffusive Natural Convection Along Inclined Plate in Porous Medium: Prescribed Surface Heat, Solute and Nanoparticles Flux

    Science.gov (United States)

    Goyal, M.; Goyal, R.; Bhargava, R.

    2017-12-01

    In this paper, triple diffusive natural convection under Darcy flow over an inclined plate embedded in a porous medium saturated with a binary base fluid containing nanoparticles and two salts is studied. The model used for the nanofluid is the one which incorporates the effects of Brownian motion and thermophoresis. In addition, the thermal energy equations include regular diffusion and cross-diffusion terms. The vertical surface has the heat, mass and nanoparticle fluxes each prescribed as a power law function of the distance along the wall. The boundary layer equations are transformed into a set of ordinary differential equations with the help of group theory transformations. A wide range of parameter values are chosen to bring out the effect of buoyancy ratio, regular Lewis number and modified Dufour parameters of both salts and nanofluid parameters with varying angle of inclinations. The effects of parameters on the velocity, temperature, solutal and nanoparticles volume fraction profiles, as well as on the important parameters of heat and mass transfer, i.e., the reduced Nusselt, regular and nanofluid Sherwood numbers, are discussed. Such problems find application in extrusion of metals, polymers and ceramics, production of plastic films, insulation of wires and liquid packaging.

  2. Efficacy and safety of NEPA, an oral combination of netupitant and palonosetron, for prevention of chemotherapy-induced nausea and vomiting following highly emetogenic chemotherapy: a randomized dose-ranging pivotal study.

    Science.gov (United States)

    Hesketh, P J; Rossi, G; Rizzi, G; Palmas, M; Alyasova, A; Bondarenko, I; Lisyanskaya, A; Gralla, R J

    2014-07-01

    NEPA is a novel oral fixed-dose combination of netupitant (NETU), a new highly selective neurokinin-1 (NK1) receptor antagonist (RA) and palonosetron (PALO), a pharmacologically and clinically distinct 5-hydroxytryptamine type 3 (5-HT3) RA. This study was designed to determine the appropriate clinical dose of NETU to combine with PALO for evaluation in the phase 3 NEPA program. This randomized, double-blind, parallel group study in 694 chemotherapy naïve patients undergoing cisplatin-based chemotherapy for solid tumors compared three different oral doses of NETU (100, 200, and 300 mg) + PALO 0.50 mg with oral PALO 0.50 mg, all given on day 1. A standard 3-day aprepitant (APR) + IV ondansetron (OND) 32 mg regimen was included as an exploratory arm. All patients received oral dexamethasone on days 1-4. The primary efficacy endpoint was complete response (CR: no emesis, no rescue medication) during the overall (0-120 h) phase. All NEPA doses showed superior overall CR rates compared with PALO (87.4%, 87.6%, and 89.6% for NEPA100, NEPA200, and NEPA300, respectively versus 76.5% PALO; P < 0.050) with the highest NEPA300 dose studied showing an incremental benefit over lower NEPA doses for all efficacy endpoints. NEPA300 was significantly more effective than PALO and numerically better than APR + OND for all secondary efficacy endpoints of no emesis, no significant nausea, and complete protection (CR plus no significant nausea) rates during the acute (0-24 h), delayed (25-120 h), and overall phases. Adverse events were comparable across groups with no dose response. The percent of patients developing electrocardiogram changes was also comparable. Each NEPA dose provided superior prevention of chemotherapy-induced nausea and vomiting (CINV) compared with PALO following highly emetogenic chemotherapy; however, NEPA300 was the best dose studied, with an advantage over lower doses for all efficacy endpoints. The combination of NETU and PALO was well tolerated with a similar

  3. In-Clinic Blood Pressure Prediction of Normal Ambulatory Blood Pressure Monitoring in Pediatric Hypertension Referrals.

    Science.gov (United States)

    Johnson, Philip K; Ferguson, Michael A; Zachariah, Justin P

    2016-07-01

    Since younger patients have low pretest probability of hypertension and are susceptible to reactive and masked hypertension, ambulatory blood pressure monitoring (ABPM) can be useful. To better target use in referred patients, we sought to define in-clinic systolic blood pressure (SBP) measures that predicted normal ABPM and target end organ damage. Data were collected on consecutive patients referred for high BP undergoing an ambulatory BP monitor from 2010 to 2013 (n = 248, 33.9% female, mean age 15.5 ± 3.6 years). Candidate in-clinic predictors were systolic maximum, minimum, or average BPs obtained by auscultative, oscillometric, or both. Multivariable logistic regression models were used to determine the prediction of normal ABPM by in-clinic BP predictors. Separate models considered predicting left ventricular hypertrophy (LVH) by in-clinic SBP vs. ABPM-defined hypertension. Identified predictor utility was tested with receiver operator characteristic curves. Maximum (OR 0.97 [95% CI 0.94-0.99]; P = .047), minimum (0.96 [0.94-0.99]; P = .002), and average (0.97 [0.95-1.00]; P = .04) in-clinic auscultative SBP predicted normal ABPM. Each had a c-statistic of 0.58. LVH was associated with in-clinic auscultative minimum SBP treated continuously (1.05, [1.01-1.10], P = .01) or dichotomized at the 90th percentile (8.23, [1.48-45.80], P = .02), as well as ABPM-defined hypertension (3.31, [1.23-8.91], P = .02). Both predictors had poor sensitivity and specificity. In youth, normal auscultative in-clinic systolic blood pressure indices weakly predicted normal ambulatory blood pressure and target end organ damage. © 2016 Wiley Periodicals, Inc.

  4. Computational stability appraisal of rectangular natural circulation loop: Effect of loop inclination

    International Nuclear Information System (INIS)

    Krishnani, Mayur; Basu, Dipankar N.

    2017-01-01

    Highlights: • Computational model developed for single-phase rectangular natural circulation loop. • Role of loop inclination to vertical on thermalhydraulic stability is explored. • Inclination has strong stabilizing effect due to lower effective gravitation force. • Increase in tilt angle reduces settling time and highest amplitude of oscillation. • An angle of 15° is suggested for the selected loop geometry. - Abstract: Controlling stability behavior of single-phase natural circulation loops, without significantly affecting its steady-state characteristics, is a topic of wide research interest. Present study explores the role of loop inclination on a particular loop geometry. Accordingly a 3D computational model of a rectangular loop is developed and transient conservation equations are solved to obtain the temporal variation in flow parameters. Starting from the quiescent state, simulations are performed for selected sets of operating conditions and also with a few selected inclination angles. System experiences instability at higher heater powers and also with higher sink temperatures. Inclination is found to have a strong stabilizing influence owing to the reduction in the effective gravitational acceleration and subsequent decline in local buoyancy effects. The settling time and highest amplitude of oscillations substantially reduces for a stable system with a small inclination. Typically-unstable systems can also suppress the oscillations, when subjected to tilting, within a reasonable period of time. It is possible to stabilize the loop within shorter time span by increasing the tilt angle, but at the expense of reduction in steady-state flow rate. Overall a tilt angle of 15° is suggested for the selected geometry. Results from the 3D model is compared with the predictions from an indigenous 1D code. While similar qualitative influence of inclination is observed, the 1D model predicts early appearance of the stability threshold and hence hints

  5. Unmanned Aerial Vehicle Mishap Taxonomy for Range Safety Reviews

    Science.gov (United States)

    2016-02-01

    Safety Group Published by Secretariat Range Commanders Council White Sands Missile Range New Mexico 88002-5100 This page...gear failure to deploy  Tail damage due to the vehicle’s sudden stop and backwards tilt on an inclined taxiway In one instance, runway operations... Technology . (19 March 2007.):44. Unmanned Aerial Vehicle Mishap Taxonomy for Range Safety Reviews, RCC 326-16, February 2016 6-4 This page intentionally

  6. ANALYSIS OF INFLUENCE OF DESIGN CHARACTERISTICS OF INCLINED BUCKET ELEVATOR ON THE POWER OF ITS DRIVE

    Directory of Open Access Journals (Sweden)

    V. M. Bohomaz

    2016-12-01

    Full Text Available Purpose.One of the main elements of the inclined belt bucket elevators is their drive. To determine the drive power, it is necessary to carry out calculations according to standard methods, which are described in the modern literature. The basic design parameters are the productivity, lifting height, type and properties of the transported material, the angle of inclination. It is necessary to build a parametric dependence of the driving power of the elevator on its design parameters, which takes into account the standard sizes and types of buckets and belts. Methodology. Using the methodology of traction calculation of inclined belt bucket elevator there were built parametric dependences of efforts in specific points of the route of the elevator, as well as the parametric dependences of the drive power of high-speed elevators with deep and shallow buckets on their design parameters and characteristics. Findings. On the basis of constructed parametric dependencies, it was found that the function of changing the value of the elevator’s power from design capacity (at fixed lifting height, type of cargo, belt speed is piecewise constant and monotonically increasing. It was built a graphical representation of elevator drive power on the angle of its inclination within acceptable limits of change. The resulting relationship is non-linear and monotonically decreasing. In general terms the intervals of project performance values, which provide a constant value of drive power of inclined elevator were defined. As an example of the obtained results it was observed the process of dependence construction of the drive power on design capacity and inclination angle of the elevator for transporting the fine coal. Originality. For the first time there were constructed the parametric dependences of drive power of inclined bucket elevator on its design parameters that take into account the standard sizes and types of buckets and belts. Practical value. Using

  7. A comparative computed tomographic evaluation of expression of angulation and inclination in self ligating brackets

    Directory of Open Access Journals (Sweden)

    Rehana Bashir

    2018-01-01

    Full Text Available Introduction: An important objective of orthodontic treatment is to obtain the correct angulation and inclination for all the teeth. Very few studies have been conducted so far comparing the expression of angulation and inclination in conventional and self-ligating brackets (SLBs. The present study was designed to evaluate and compare the inclination and angulation in conventional brackets and active and passive SLBs. Materials and Methods: Totally 21 patients who required four 1st premolar extractions were selected and were randomly allotted to three groups: Group 1: Conventional Brackets (3M Unitek MBT (mean age 19.14 ± 2.12 years, Group 2: Passive Brackets (Smart Clip Brackets-3M Unitek MBT (mean age 19.71 ± 1.80 years, Group 3: Active Brackets (Empower Brackets-American Orthodontics MBT (mean age 18.29 ± 2.29 years computed tomographic records were collected before the start of treatment, after leveling and aligning and at 6 months into retraction. Results: The data were evaluated using SPSS version 16.0 using one-way ANOVA and post hoc Bonferroni tests. There was no statistically significant difference in the expression of angulation and inclination in conventional, active, and passive SLB systems. Conclusion: Self-ligating brackets seem to be no better than conventional brackets when it comes to the expression of angulation and inclination.

  8. A Liquid-Surface-Based Three-Axis Inclination Sensor for Measurement of Stage Tilt Motions.

    Science.gov (United States)

    Shimizu, Yuki; Kataoka, Satoshi; Ishikawa, Tatsuya; Chen, Yuan-Liu; Chen, Xiuguo; Matsukuma, Hiraku; Gao, Wei

    2018-01-30

    In this paper a new concept of a liquid-surface-based three-axis inclination sensor for evaluation of angular error motion of a precision linear slide, which is often used in the field of precision engineering such as ultra-precision machine tools, coordinate measuring machines (CMMs) and so on, is proposed. In the liquid-surface-based three-axis inclination sensor, a reference float mounting a line scale grating having periodic line grating structures is made to float over a liquid surface, while its three-axis angular motion is measured by using an optical sensor head based on the three-axis laser autocollimation capable of measuring three-axis angular motion of the scale grating. As the first step of research, in this paper, theoretical analysis on the angular motion of the reference float about each axis has been carried out based on simplified kinematic models to evaluate the possibility of realizing the proposed concept of a three-axis inclination sensor. In addition, based on the theoretical analyses results, a prototype three-axis inclination sensor has been designed and developed. Through some basic experiments with the prototype, the possibility of simultaneous three-axis inclination measurement by the proposed concept has been verified.

  9. Investigation of Oriented Magnetic Field Effects on Entropy Generation in an Inclined Channel Filled with Ferrofluids

    Directory of Open Access Journals (Sweden)

    Elgiz Baskaya

    2017-07-01

    Full Text Available Dispersion of super-paramagnetic nanoparticles in nonmagnetic carrier fluids, known as ferrofluids, offers the advantages of tunable thermo-physical properties and eliminate the need for moving parts to induce flow. This study investigates ferrofluid flow characteristics in an inclined channel under inclined magnetic field and constant pressure gradient. The ferrofluid considered in this work is comprised of Cu particles as the nanoparticles and water as the base fluid. The governing differential equations including viscous dissipation are non-dimensionalised and discretized with Generalized Differential Quadrature Method. The resulting algebraic set of equations are solved via Newton-Raphson Method. The work done here contributes to the literature by searching the effects of magnetic field angle and channel inclination separately on the entropy generation of the ferrofluid filled inclined channel system in order to achieve best design parameter values so called entropy generation minimization is implemented. Furthermore, the effect of magnetic field, inclination angle of the channel and volume fraction of nanoparticles on velocity and temperature profiles are examined and represented by figures to give a thorough understanding of the system behavior.

  10. Study on natural circulation characteristics of an IPWR under inclined and rolling condition

    Energy Technology Data Exchange (ETDEWEB)

    He, Lihui [College of Computer Science and Information Technology, Harbin Normal University, Harbin (China); Wang, Bing [Fundamental Science on Nuclear Safety and Simulation Technology Laboratory, Harbin Engineering University, Harbin (China); Xia, Genglei, E-mail: xiagenglei@163.com [Fundamental Science on Nuclear Safety and Simulation Technology Laboratory, Harbin Engineering University, Harbin (China); Peng, Minjun [Fundamental Science on Nuclear Safety and Simulation Technology Laboratory, Harbin Engineering University, Harbin (China)

    2017-06-15

    Highlights: • An ocean-based thermal-hydraulic analysis code was developed based on RELAP5 codes. • The inclination condition can reduce the mass flow rate of reactor core. • The system parameters asymmetry increases with the increasing inclination angle. • Flow oscillation of different loops cancel each other due to the symmetrical arrangement of the reactor. • The off-center roll axis location can break the symmetry and enlarge fluctuation amplitude of the core flow rate. - Abstract: An ocean-based thermal-hydraulic system analysis code was developed based on RELAP5/MOD3 code by adding additional force model of ocean condition and control volume coordinate solver model. The natural circulation operation characteristics of integrated pressurized water reactor (IPWR) under ocean conditions were studied and the effects of inclination and rolling motions were analyzed. The results conclude that, the inclination condition can reduce the mass flow rate of reactor core and lead to inconsistent coolant flow rates of the left and right loops, furthermore, it affects the heat transfer of once-through steam generators (OTSGs). In the case of rolling motion, the additional pressure drop of the loop is dominated by tangential force, and flow oscillation of different loops cancel each other due to the symmetrical arrangement of the reactor. The off-center roll axis location, the combination of the inclination and rolling motion, both can break the thermal-hydraulic symmetry among different loops and enlarge fluctuation amplitude of the core flow rate.

  11. Peri-implant strain around mesially inclined two-implant-retained mandibular overdentures with Locator attachments.

    Science.gov (United States)

    Elsyad, Moustafa A; Eltowery, Salem M; Gebreel, Ashraf A

    2017-12-27

    This study aimed to evaluate the peri-implant strain around mesially inclined implants used to retain mandibular overdentures with Locator resilient attachments. Four mandibular edentulous acrylic resin models received two implants in the canine areas with 0°, 5°, 10°, and 20° mesial inclinations. Overdentures were connected to the implants using Locator attachments. Pink nylon inserts (light retention) were used for all implant inclinations, and red inserts were used for 20° inclination (20°red). Four strain gages were bonded on the mesial (M), distal (D), buccal (B), and lingual (L) surfaces of each implant. Peri-implant strains were measured during bilateral and unilateral loading. The 20° inclination showed the highest strain, followed by 10° and 5°, and both 0° and 20°red presented with the lowest strain. Site D was associated with the highest strain, followed by M, B, and L, which showed the lowest strain values. Unilateral loading and the loading side presented with significantly higher strain values than bilateral loading and the nonloading side, respectively. Hence, in this study, strains around the two-implant-retained overdentures with Locator attachments increased with increases in mesial implant angulation, except when red male inserts were used.

  12. Walking on inclines: how do desert ants monitor slope and step length

    Directory of Open Access Journals (Sweden)

    Seidl Tobias

    2008-06-01

    Full Text Available Abstract Background During long-distance foraging in almost featureless habitats desert ants of the genus Cataglyphis employ path-integrating mechanisms (vector navigation. This navigational strategy requires an egocentric monitoring of the foraging path by incrementally integrating direction, distance, and inclination of the path. Monitoring the latter two parameters involves idiothetic cues and hence is tightly coupled to the ant's locomotor behavior. Results In a kinematic study of desert ant locomotion performed on differently inclined surfaces we aimed at pinpointing the relevant mechanisms of estimating step length and inclination. In a behavioral experiment with ants foraging on slippery surfaces we broke the otherwise tightly coupled relationship between stepping frequency and step length and examined the animals' ability to monitor distances covered even under those adverse conditions. We show that the ants' locomotor system is not influenced by inclined paths. After removing the effect of speed, slope had only marginal influence on kinematic parameters. Conclusion From the obtained data we infer that the previously proposed monitoring of angles of the thorax-coxa joint is not involved in inclinometry. Due to the tiny variations in cycle period, we also argue that an efference copy of the central pattern generator coding the step length in its output frequency will most likely not suffice for estimating step length and complementing the pedometer. Finally we propose that sensing forces acting on the ant's legs could provide the desired neuronal correlate employed in monitoring inclination and step length.

  13. Experimental studies on the flow characteristics in an inclined bend-free OWC device

    Directory of Open Access Journals (Sweden)

    Krishnil Ravinesh Ram

    2016-01-01

    Full Text Available A bend-free rectangular cross-section OWC device was designed and constructed for studying the effect of inclination on the flow characteristics inside the device. The inclination is meant to reduce reflection of waves and induce higher velocities in the turbine section. Experimental measurements were made in a wave channel where the OWC device was tested. An S-type Pitot tube was used to measure dynamic pressure of air in the turbine section at several inclinations. Particle Image Velocimetry (PIV was also done to study the flow of both air and water in the OWC device. In order to focus solely on primary energy capture, no turbine was installed in the OWC device. The dynamic pressure readings were analysed for suction and compression stages. Water volume fluctuations inside the capture chamber were also recorded and compared for different inclinations. The result was an increase in the velocity of air flowing in the capture chamber and hence a rise in the kinetic energy available to the turbine. It was found from experimental studies that as the angle of inclination reduced, the velocity of air in the turbine section increased. The lower angles also caused higher run-up and larger volume of water into the capture chamber.

  14. Experimental investigation on steady granular flows interacting with an obstacle down an inclined channel: study of the dead zone upstream from the obstacle. Application to interaction between dense snow avalanches and defence structures

    Directory of Open Access Journals (Sweden)

    T. Faug

    2002-01-01

    Full Text Available An experimental investigation with dry granular flows passing over an obstacle down a rough inclined channel has been performed. The aim is to improve our understanding of the interaction between dense snow avalanches and defence structures. Specific attention was directed to the study of the zone of influence upstream from the obstacle, linked to the formation of a dead zone. The dead zone length L was systematically measured as a function of the obstacle height H and the channel inclination θ, for several discharges. In a whole range of channel inclinations, all the data are shown to collapse into a single curve when properly scaled. The scaling is based on the introduction of a theoretical deposit length (depending on H, θ and the internal friction angle of the material, φ and a Froude number of the flow depending on the obstacle height.

  15. AVE5026, a new hemisynthetic ultra-low-molecular-weight heparin for the prevention of venous thromboembolism in patients after total knee replacement surgery--TREK: a dose-ranging study

    DEFF Research Database (Denmark)

    Lassen, M R; Dahl, O E; Mismetti, P

    2009-01-01

    -daily doses of AVE5026 (5, 10, 20, 40, or 60 mg) or enoxaparin 40 mg in the calibrator arm. The primary efficacy end point was VTE until post-operative day 11, defined as deep vein thrombosis (DVT) detected by bilateral venography, symptomatic DVT, non-fatal pulmonary embolism (PE) and VTE-related death...

  16. Hydromagnetic and Soret driving free convection in an inclined porous cavity saturated by a conducting binary mixture

    Directory of Open Access Journals (Sweden)

    Amahmid A.

    2012-07-01

    Full Text Available We consider the Soret convection in an inclined rectangular Darcy porous medium filled with an electrically conductive binary fluid. The long sidewalls of the porous cavity are subject to constant gradients of heat and submitted to a uniform and constant transversal magnetic field while its short sides are adiabatic and impermeable. An approximate analytical solution to the present problem, valid in the central part of the shallow cavity, is obtained on the basis of the parallel flow approximation and validated numerically using a finite-difference method. Results are presented in terms of streamlines, isotherms, iso-concentration lines, Nusselt and Sherwood numbers and separation of species for Hartmann number varying in the range [0, 20]. A good agreement is observed between the analytical predictions and numerical simulations.

  17. Motion of a carrier with a mobile load along a rough inclined plane

    Science.gov (United States)

    Bilchenko, G. G.

    2018-03-01

    The mechanical system consisting of a carrier and a load is considered. The load can move respectively the carrier according to the preset given motion law. The carrier motion from rest caused the load motion is investigated. The carrier can move translationally along rectilinear trajectory along rough inclined plane. The trajectory is the line of the greatest descent. The axis of rectilinear channel along which the load moves is situated in vertical plane containing the carrier trajectory. The Coulomb model is taken to describe the friction forces on sloped plane. Differential equations of motion of carrier with load are obtained. The sufficient condition of the carrier motion without detachment from inclined plane is given. For two special cases of the channel installation angle and the plane inclination angle combination the motion types are described. The computation experiments results are presented: the carrier motions in the special cases are illustrated, the phase portraits for some types of motions are constructed.

  18. HEAT EXCHANGE AND AERODYNAMICS OF THE COMBINED TUBING BUNDLES WITH CROSS INCLINED FINS

    Directory of Open Access Journals (Sweden)

    Knyazyuk V. I

    2013-04-01

    Full Text Available The paper presents results of experimental research and analyses air-side thermal performance of combined tube bundles with cross inclined fins. The empirical correlations for heat transfer and flow friction of tubes with inclined fins at different orientation finned tubes relatively of air flow are presented. The errors of thermal and aerodynamic tests are 3-5% and 9.2%, respectively. The proposed correlations describe an experimental data with a coefficient of determination about 0.979-0.998. The impact of tubes arrangement in a bundle on energy performance of heat exchanger were analyzed using complete and local heat modeling methods at a stationary heat flux. Experimental research indicates that efficiency of inclined fins can be calculated by using the equation for cross rectangular fins with average deviation of ±5 %.

  19. [Reliability study in the measurement of the cusp inclination angle of a chairside digital model].

    Science.gov (United States)

    Xinggang, Liu; Xiaoxian, Chen

    2018-02-01

    This study aims to evaluate the reliability of the software Picpick in the measurement of the cusp inclination angle of a digital model. Twenty-one trimmed models were used as experimental objects. The chairside digital impression was then used for the acquisition of 3D digital models, and the software Picpick was employed for the measurement of the cusp inclination of these models. The measurements were repeated three times, and the results were compared with a gold standard, which was a manually measured experimental model cusp angle. The intraclass correlation coefficient (ICC) was calculated. The paired t test value of the two measurement methods was 0.91. The ICCs between the two measurement methods and three repeated measurements were greater than 0.9. The digital model achieved a smaller coefficient of variation (9.9%). The software Picpick is reliable in measuring the cusp inclination of a digital model.

  20. Numerical study of heat and mass transfer optimization in a 3D inclined solar distiller

    Directory of Open Access Journals (Sweden)

    Ghachem Kaouther

    2017-01-01

    Full Text Available A numerical study of the 3-D double-diffusive natural convection in an inclined solar distiller was established. The flow is considered laminar and caused by the interaction of thermal energy and the chemical species diffusions. The governing equations of the problem, are formulated using vector potential-vorticity formalism in its 3-D form, then solved by the finite volumes method. The Rayleigh number is fixed at Ra = 105 and effects of the buoyancy ratio and inclination are studied for opposed temperature and concentration gradients. The main purpose of the study is to find the optimum inclination angle of the distiller which promotes the maximum mass and heat transfer.

  1. Flow behaviour and local concentration of coarse particles-water mixture in inclined pipes

    Directory of Open Access Journals (Sweden)

    Vlasak Pavel

    2017-06-01

    Full Text Available Narrow particle size distribution basalt pebbles of mean particle size 11.5 mm conveyed by water in the pipe sections of different inclination were investigated on an experimental pipe loop, consisting of smooth stainless steel pipes of inner diameter D = 100 mm. Mixture flow-behaviour and particles motion along the pipe invert were studied in a pipe viewing section, the concentration distribution in pipe cross-section was studied with the application of a gamma-ray densitometer. The study refers to the effect of mixture velocity, overall concentration, and angle of pipe inclination on chord-averaged concentration profiles and local concentration maps, and flow behaviour of the coarse particle-water mixtures. The study revealed that the coarse particle-water mixtures in the inclined pipe sections were significantly stratified, the solid particles moved principally close to the pipe invert, and for higher and moderate flow velocities particle saltation becomes the dominant mode of particle conveying.

  2. Experimental investigation of coarse particles-water mixture flow in horizontal and inclined pipes

    Directory of Open Access Journals (Sweden)

    Vlasák Pavel

    2014-09-01

    Full Text Available The effect of solid concentration and mixture velocity on the flow behaviour, pressure drops, and concentration distribution of coarse particle-water mixtures in horizontal, vertical, and inclined smooth stainless steel pipes of inner diameter D = 100 mm was experimentally investigated. Graded basalt pebbles were used as solid particles. The study revealed that the coarse-grained particle-water mixtures in the horizontal and inclined pipes were significantly stratified. The solid particles moved principally in a layer close to the pipe invert; however for higher and moderate flow velocities, particle saltation became the dominant mode of particle conveyance. Frictional pressure drops in the horizontal pipe were found to be markedly higher than in the vertical pipe, while the frictional pressure drops in the ascending pipe increased with inclination angle up to about 30°.

  3. Measurement of capacity coefficient of inclined liquid phase catalytic exchange column for tritiated water processing

    International Nuclear Information System (INIS)

    Yamai, Hideki; Konishi, Satoshi; Yamanishi, Toshihiko; Okuno, Kenji

    1994-01-01

    Liquid phase catalytic exchange (LPCE) is effective method for enrichment and removal of tritium from tritiated water. Capacity coefficients of operating LPCE column that are essential to evaluate column performance were measured. Experiments were performed with short catalyst packed columns and effect of inclination was studied. Method for evaluation of capacity coefficients was established from measurement of isotope concentration of liquid, vapor, gas phases at the two ends of the column. The capacity coefficients were measured under various superficial gas velocities. Feasibility study of helical columns with roughened inner surface was performed with short inclined columns. The column performance was not strongly affected by the inclination. The result indicates technological feasibility of helical LPCE column, that is expected to have operation stability and reduced height

  4. Aerodynamics of flapping insect wing in inclined stroke plane hovering with ground effect

    Science.gov (United States)

    Gowda v, Krishne; Vengadesan, S.

    2014-11-01

    This work presents the time-varying aerodynamic forces and the unsteady flow structures of flapping insect wing in inclined stroke plane hovering with ground effect. Two-dimensional dragonfly model wing is chosen and the incompressible Navier-Stokes equations are solved numerically by using immersed boundary method. The main objective of the present work is to analyze the ground effect on the unsteady forces and vortical structures for the inclined stroke plane motions. We also investigate the influences of kinematics parameters such as Reynolds number (Re), stroke amplitude, wing rotational timing, for various distances between the airfoil and the ground. The effects of aforementioned parameters together with ground effect, on the stroke averaged force coefficients and regimes of force behavior are similar in both normal (horizontal) and inclined stroke plane motions. However, the evolution of the vortex structures which produces the effects are entirely different.

  5. A Phase 2 randomized, observer-blind, placebo-controlled, dose-ranging trial of aluminum-adjuvanted respiratory syncytial virus F particle vaccine formulations in healthy women of childbearing age.

    Science.gov (United States)

    August, Allison; Glenn, Gregory M; Kpamegan, Eloi; Hickman, Somia P; Jani, Dewal; Lu, Hanxin; Thomas, D Nigel; Wen, Judy; Piedra, Pedro A; Fries, Louis F

    2017-06-27

    Respiratory syncytial virus (RSV) causes significant morbidity and mortality in infants. We are developing an RSV fusion (F) protein nanoparticle vaccine for immunization of third trimester pregnant women to passively protect infants through transfer of RSV-specific maternal antibodies. The present trial was performed to assess the immunogenicity and safety of several formulations of RSV F vaccine in 1-dose or 2-dose schedules. Placebo, or vaccine with 60μg or 120μg RSV F protein and 0.2, 0.4, or 0.8mg aluminum, were administered intramuscularly on Days 0 and 28 to healthy women 18-35years old. Immunogenicity was assessed from Days 0 through 91 based on anti-F IgG and palivizumab-competitive antibody (PCA) by ELISA, and RSV A and B neutralizing antibodies by microneutralization (MN) assay. Solicited adverse events were collected through Day 7 and unsolicited adverse events through Day 91. All formulations were well-tolerated, with no treatment-related serious adverse events. Anti-F IgG and PCA responses were correlated and increased after both doses, while MN increased significantly only after the first dose, then plateaued. The timeliest and most robust antibody responses followed one dose of 120μg RSV F protein and 0.4mg aluminum, but persistence through 91days was modestly (∼25%) superior following two doses of 60μg RSV F protein and 0.8mg aluminum. Western blot analysis showed RSV infections in active vaccinees were reduced by 52% overall (p=0.009 overall) over the Day 0 through 90 period. RSV F nanoparticle vaccine formulations were well tolerated and immunogenic. The optimal combination of convenience and rapid response for immunization in the third trimester occurred with 120μg RSV F and 0.4mg aluminum, which achieved peak immune responses in 14days and sufficient persistence through 91days to allow for passive transfer of IgG antibodies to the fetus. NCT01960686. Copyright © 2017 Novavax. Published by Elsevier Ltd.. All rights reserved.

  6. Numerical investigation of turbulent natural convection in an inclined square cavity with a hot wavy wall

    Energy Technology Data Exchange (ETDEWEB)

    Aounallah, M.; Imine, O.; Adjlout, L. [Department of Marine Engineering, Faculty of Mechanics, P.O. Box 1505, El-Mnaouar (Algeria); Addad, Y. [School of Mechanical, Aerospace and Civil Engineering, The University of Manchester, P.O. Box 88, Sackville Street, Manchester M60 1QD (United Kingdom); Benhamadouche, S.; Laurence, D. [School of Mechanical, Aerospace and Civil Engineering, The University of Manchester, P.O. Box 88, Sackville Street, Manchester M60 1QD (United Kingdom); Electricite de France R and D, Departement de Mecanique des Fluides et Transferts Thermiques (MFTT), 6 Quai Watier, 78400 Chatou (France)

    2007-05-15

    The turbulent natural convection of air flow in a confined cavity with two differentially heated side walls is investigated numerically up to Rayleigh number of 10{sup 12}. The objective of the present work is to study the effect of the inclination angle and the amplitude of the undulation on turbulent heat transfer. The low-Reynolds-number k-{epsilon}, k-{omega}, k-{omega}-SST RANS models and a coarse DNS are used and compared to the experimental benchmark data of Ampofo and Karayiannis [F. Ampofo, T.G. Karayiannis, Experimental benchmark data for turbulent natural convection in an air filled square cavity, Int. J. Heat Mass Transfer 46 (2003) 3551-3572]. The k-{omega}-SST model is then used for the following test-cases as it gives the closest results to experimental data and coarse DNS for this case. The mean flow quantities and temperature field show good agreement with coarse DNS and measurements, but there are some slight discrepancies in the prediction of the turbulent statistics. Also, the numerical results of the heat flux at the hot wall are over predicted. The strong influence of the undulation of the cavity and its orientation is well shown. The trend of the local heat transfer is wavy with different frequencies for each undulation. The turbulence causes an increase in the convective heat transfer on the wavy wall surface compared to the square cavity for high Rayleigh numbers. A correlation of the mean Nusselt number function of the Rayleigh number is also proposed for the range of Rayleigh numbers of 10{sup 9}-10{sup 12}. (author)

  7. Stability of hierarchical triples - I. Dependence on inner eccentricity and inclination

    Science.gov (United States)

    Mylläri, A.; Valtonen, M.; Pasechnik, A.; Mikkola, S.

    2018-05-01

    In simulations it is often important to decide if a given hierarchical triple star system is stable over an extended period of time. We introduce a stability criterion, modified from earlier work, where we use the closest approach ratio Q of the third star to the inner binary centre of mass in their initial osculating orbits. We study by numerical integration the orbits of over 1000 000 triple systems of the fixed masses and outer eccentricities eout, but varying inner eccentricities ein and inclinations i. 12 primary combinations of masses have been tried, representing the range encountered in stellar systems. The definition of the instability is either the escape of one of the bodies, or the exchange of the members between the inner and outer systems. An analytical approximation is derived using the energy change in a single close encounter between the inner and outer systems, assuming that the orbital phases in subsequent encounters occur randomly. The theory provides a fairly good description of the typical Qst, the smallest Q value that allows the system to be stable over N = 10 000 revolutions of the initial outer orbit. The final stability limit formula is Qst = 101/3A[( f g)2/(1 - eout)]1/6, where the coefficient A ˜ 1 should be used in N-body experiments, and A = 2.4 when the absolute long-term stability is required. The functions f (ein, cos i) and g(m1, m2, m3) are derived in the paper. At the limit of ein = i = m3 = 0, f g = 1.

  8. A waveless two-dimensional flow in a channel against an inclined wall with surface tension effect

    International Nuclear Information System (INIS)

    Merzougui, Abdelkrim; Mekias, Hocine; Guechi, Fairouz

    2007-01-01

    Surface tension effect on a two-dimensional channel flow against an inclined wall is considered. The flow is assumed to be steady, irrotational, inviscid and incompressible. The effect of surface tension is taken into account and the effect of gravity is neglected. Numerical solutions are obtained via series truncation procedure. The problem is solved numerically for various values of the Weber number α and for various values of the inclination angle β between the horizontal bottom and the inclined wall

  9. Comparison of the Activity of the Gluteus Medius According to the Angles of Inclination of a Treadmill with Vertical Load

    OpenAIRE

    Jeong, Da-Eun; Lee, Su-Kyoung; Kim, Kyoung

    2014-01-01

    [Purpose] The purpose of this study was to compare the muscle activity of the gluteus medius according to treadmill inclination during gait with a vertical load on a treadmill. [Methods] Sixteen healthy subjects were recruited for this study. The subjects walked on a treadmill at inclination angles of 0, 5, and 10 degrees. [Results] Muscle activity of the gluteus medius increased at 5° compared to 0° treadmill inclination, though the difference was not significant. On the other hand, gluteus ...

  10. Detecting and correcting for paleomagnetic inclination shallowing of sedimentary rocks: A review

    Directory of Open Access Journals (Sweden)

    Yong-Xiang eLi

    2016-02-01

    Full Text Available Magnetic anisotropy and the elongation/inclination (E-I approaches have been increasingly employed as two important means for detecting and correcting the paleomagnetic inclination shallowing in sedimentary rocks that was first recognized sixty years ago. Both approaches are based on certain assumptions, and thus have advantages and intrinsic limitations in investigating shallow inclinations in sedimentary rocks. The E-I approach is relatively easy to use, but it needs a large dataset to adequately sample paleomagnetic directions due to paleosecular variation of the geomagnetic field. Also, slow sediment accumulation rates and local tectonics could lead to under- or over-corrections using the E-I approach. For the magnetic anisotropy technique, labor-intensive, sophisticated laboratory rock magnetic experiments are required in order to accurately determine both bulk magnetic anisotropy of remanence-carrying grains and magnetic anisotropy of an individual particle, i.e., a factor, of samples. Our review shows that, despite the intensive laboratory work necessary for applying anisotropy-based inclination corrections, it is worth investing the effort. In addition, the joint use of magnetic susceptibility and remanence anisotropy measurements as well as detailed rock magnetic measurements for determining the particle anisotropy a factor have the advantage of retrieving direct evidence of inclination shallowing and correcting for it with high confidence. We caution against use of either of the two approaches without full appreciation of the underlying assumptions and intrinsic limitations of each technique. The use and comparison of both techniques could provide the most robust inclination shallowing correction for sedimentary rocks.

  11. Detecting and correcting for paleomagnetic inclination shallowing of sedimentary rocks: A review

    Science.gov (United States)

    Li, Yong-Xiang; Kodama, Kenneth

    2016-02-01

    Magnetic anisotropy and the elongation/inclination (E-I) approaches have been increasingly employed as two important means for detecting and correcting the paleomagnetic inclination shallowing in sedimentary rocks that was first recognized sixty years ago. Both approaches are based on certain assumptions, and thus have advantages and intrinsic limitations in investigating shallow inclinations in sedimentary rocks. The E-I approach is relatively easy to use, but it needs a large dataset to adequately sample paleomagnetic directions due to paleosecular variation of the geomagnetic field. Also, slow sediment accumulation rates and local tectonics could lead to under- or over-corrections using the E-I approach. For the magnetic anisotropy technique, labor-intensive, sophisticated laboratory rock magnetic experiments are required in order to accurately determine both bulk magnetic anisotropy of remanence-carrying grains and magnetic anisotropy of an individual particle, i.e., "a" factor, of samples. Our review shows that, despite the intensive laboratory work necessary for applying anisotropy-based inclination corrections, it is worth investing the effort. In addition, the joint use of magnetic susceptibility and remanence anisotropy measurements as well as detailed rock magnetic measurements for determining the particle anisotropy "a" factor have the advantage of retrieving direct evidence of inclination shallowing and correcting for it with high confidence. We caution against use of either of the two approaches without full appreciation of the underlying assumptions and intrinsic limitations of each technique. The use and comparison of both techniques could provide the most robust inclination shallowing correction for sedimentary rocks.

  12. COMPARISON OF PLANTAR PRESSURE DISTRIBUTION BETWEEN DIFFERENT SPEED AND INCLINE DURING TREADMILL JOGGING

    Directory of Open Access Journals (Sweden)

    I-Ju Ho

    2010-03-01

    Full Text Available The aim of this study was to examine the effect of changes in speed and incline slope on plantar pressure distribution of the foot during treadmill jogging. Plantar pressure parameters were measured with the Pedar-X system in twenty healthy girls (mean age of 20.7 years, mean height of 1.60m, and a mean weight of 53.35kg. Because variations in walking speed or slope can significantly change the magnitude of plantar pressure, comparisons of plantar pressure distribution between the two independent protocols during treadmill jogging were considered in this study. First, the subjects ran at the same speed of 2 m·s-1 with different incline slopes of 0%, 5%, 10%, and 15%. Second, they ran on the same slope of 0% with different speeds of 1.5 m·s-1, 2.0 m·s-1, and 2.5 m·s-1. The peak pressure of the eight plantar surface areas, apart from the medial forefoot and the hallux, significantly increased (p < 0.05 with an increase of 33% of peak pressure from 1.5 m·s-1 to 2.5 m·s-1 (speed at heel region. In contrast, the peak pressures at the heel, medial fore-foot, toe and hallux decreased significantly (p < 0. 05 with increasing incline slope. At the heel, peak pressure reduced by 27% from 0% to 15% incline, however, pressure at the lateral midfoot region increased as following. Different speeds and incline slopes during jogging were associated with changes in plantar pressures. By systematic investigation of foot kinematics and plantar pressure during jogging with varying incline slope and speed, the results of this study provided further insight into foot biomechanics during jogging

  13. Revealing the inclined circumstellar disk in the UX Ori system KK Ophiuchi

    Science.gov (United States)

    Kreplin, A.; Weigelt, G.; Kraus, S.; Grinin, V.; Hofmann, K.-H.; Kishimoto, M.; Schertl, D.; Tambovtseva, L.; Clausse, J.-M.; Massi, F.; Perraut, K.; Stee, Ph.

    2013-07-01

    We study the inner sub-AU region of the circumstellar environment of the UX Ori type star KK Oph with near-infrared VLTI/AMBER interferometry. We are particularly interested in the inclination of the star-disk system, and we will use this information to test the current standard picture for UX Ori stars. We recorded spectrally dispersed (R˜35) interferograms in the near-infrared H and K bands with the VLTI/AMBER instrument. The derived visibilities, closure phases and the SED of KK Oph were compared with two-dimensional geometric and radiative transfer models (RADMC). We obtained visibilities at four different position angles. Using two-dimensional geometric models, we derive an axis ratio ˜3.0 corresponding to an inclination of ˜70 degree. A fitted inclined ring model leads to a ring radius of 2.8 ± 0.2 mas, corresponding to 0.44 ± 0.03 AU at a distance of 160 pc, which is larger than the dust sublimation radius of ˜0.1 AU predicted for a dust sublimation temperature of 1500 K. Our derived two-dimensional RADMC model consists of a circumstellar disk with an inclination angle of ˜70 degree and an additional dust envelope. The finding of an ˜70 degree inclined disk around KK Oph is consistent with the prediction that UX Ori objects are seen under large inclination angles, and orbiting clouds in the line of sight cause the observed variability. Furthermore, our results suggest that the orbit of the companion KK Oph B and the disk plane are coplanar.

  14. Revealing the inclined circumstellar disk in the UX Orionis system KK Ophiuchi

    Science.gov (United States)

    Kreplin, A.; Weigelt, G.; Kraus, S.; Grinin, V.; Hofmann, K.-H.; Kishimoto, M.; Schertl, D.; Tambovtseva, L.; Clausse, J.-M.; Massi, F.; Perraut, K.; Stee, Ph.

    2013-03-01

    Aims: We study the inner sub-AU region of the circumstellar environment of the UX Ori-type star KK Oph with near-infrared VLTI/AMBER interferometry. We are particularly interested in the inclination of the star-disk system, and we use this information to test the current standard picture for UX Ori stars. Methods: We recorded spectrally dispersed (R ~ 35) interferograms in the near-infrared H and K bands with the VLTI/AMBER instrument. The derived visibilities, closure phases, and the spectral energy distribution of KK Oph were compared with two-dimensional geometric and radiative transfer models (RADMC). Results: We obtained visibilities at four different position angles. Using two-dimensional geometric models, we derive an axis ratio ~3.0 corresponding to an inclination of ~70°. A fitted inclined ring model leads to a ring radius of 2.8 ± 0.2 mas, corresponding to 0.44 ± 0.03 AU at a distance of 160 pc, which is larger than the dust sublimation radius of ~0.1 AU predicted for a dust sublimation temperature of 1500 K. Our derived two-dimensional RADMC model consists of a circumstellar disk with an inclination angle of ~70° and an additional dust envelope. Conclusions: The finding of an ~70° inclined disk around KK Oph is consistent with the prediction that UX Ori objects are seen under large inclination angles, and orbiting clouds in the line of sight cause the observed variability. Furthermore, our results suggest that the orbit of the companion KK Oph B and the disk plane are coplanar. Based on observations made with ESO telescopes at Paranal Observatory under program ID: 083.D-0224(C) and 088.C-0575(A).

  15. A Dual Conductance Sensor for Simultaneous Measurement of Void Fraction and Structure Velocity of Downward Two-Phase Flow in a Slightly Inclined Pipe.

    Science.gov (United States)

    Lee, Yeon-Gun; Won, Woo-Youn; Lee, Bo-An; Kim, Sin

    2017-05-08

    In this study, a new and improved electrical conductance sensor is proposed for application not only to a horizontal pipe, but also an inclined one. The conductance sensor was designed to have a dual layer, each consisting of a three-electrode set to obtain two instantaneous conductance signals in turns, so that the area-averaged void fraction and structure velocity could be measured simultaneously. The optimum configuration of the electrodes was determined through numerical analysis, and the calibration curves for stratified and annular flow were obtained through a series of static experiments. The fabricated conductance sensor was applied to a 45 mm inner diameter U-shaped downward inclined pipe with an inclination angle of 3° under adiabatic air-water flow conditions. In the tests, the superficial velocities ranged from 0.1 to 3.0 m/s for water and from 0.1 to 18 m/s for air. The obtained mean void fraction and the structure velocity from the conductance sensor were validated against the measurement by the wire-mesh sensor and the cross-correlation technique for the visualized images, respectively. The results of the flow regime classification and the corresponding time series of the void fraction at a variety of flow velocities were also discussed.

  16. A Dual Conductance Sensor for Simultaneous Measurement of Void Fraction and Structure Velocity of Downward Two-Phase Flow in a Slightly Inclined Pipe

    Directory of Open Access Journals (Sweden)

    Yeon-Gun Lee

    2017-05-01

    Full Text Available In this study, a new and improved electrical conductance sensor is proposed for application not only to a horizontal pipe, but also an inclined one. The conductance sensor was designed to have a dual layer, each consisting of a three-electrode set to obtain two instantaneous conductance signals in turns, so that the area-averaged void fraction and structure velocity could be measured simultaneously. The optimum configuration of the electrodes was determined through numerical analysis, and the calibration curves for stratified and annular flow were obtained through a series of static experiments. The fabricated conductance sensor was applied to a 45 mm inner diameter U-shaped downward inclined pipe with an inclination angle of 3° under adiabatic air-water flow conditions. In the tests, the superficial velocities ranged from 0.1 to 3.0 m/s for water and from 0.1 to 18 m/s for air. The obtained mean void fraction and the structure velocity from the conductance sensor were validated against the measurement by the wire-mesh sensor and the cross-correlation technique for the visualized images, respectively. The results of the flow regime classification and the corresponding time series of the void fraction at a variety of flow velocities were also discussed.

  17. Analysis of three-dimensional interference patterns of an inclined capillary.

    Science.gov (United States)

    Zhang, Yiding; Xu, Mingfeng; Tian, Wenjing; Xu, Qiwei; Xiao, Jinghua

    2016-08-01

    We study the interference patterns from an inclined capillary tube filled with liquid by using the ray tracing method and interference theory. A beautiful elliptical pattern is found on the screen, with refined fringes embedded in it. Particularly, the fringes on top of the pattern are continuously swallowed to the center with the angle of incidence increasing. In addition, a method is demonstrated to determine the refractive index of the liquid and the wavelength of the incident light by measuring the capillary tilt of every 10-fringe being swallowed, which looks like fringe crossover, with respect to the change of the inclined angle of the capillary.

  18. Model and experimental vizualisation of a bubble interacting with an inclined wall

    Science.gov (United States)

    Podvin, Berengere; Khoja, Suleman; Attinger, Daniel; Moraga, Francisco

    2006-11-01

    We describe the motion of an air bubble rising through water as it interacts with a wall of variable inclination. The bubble diameter varies about O(1) mm. We use lubrication theory to determine the modification of the bubble interface and compute the hydrodynamic force exerted by the wall. The present work is an extension of Moraga et al's model [Computers and Fluids 2006], which was devised for a horizontal wall. The predictions of the model are checked against experimental visualizations. The influence of the Weber number, Reynolds number and wall inclination is examined

  19. QUALITATIVE ANALYSIS OF DEPENDENCE OF DRIVE POWER HORIZONTAL-INCLINED BELT CONVEYOR ON ITS INITIAL PARAMETERS

    Directory of Open Access Journals (Sweden)

    V. M. Bohomaz

    2017-02-01

    Full Text Available Purpose.One of the main elements of band conveyors is a drive. To analyze the effect of design parameters on the drive power it is necessary to carry out the calculations according to standard procedures outlined in the current technical literature. The main design parameters of the band conveyor are: the type of cargo, project performance, the geometric dimensions of sections and track configuration as a whole. The feature of band conveyor calculation as compared to the elevators is the dependence of the band width on its performance, the inclination angle and the type of cargo. In the article for the account of this fact during calculations it is necessary to construct the dependence of the band width on the generalized parameter, which takes into account change in the design parameters. To determine the general pattern of changing the value of band conveyor drive power when varying its design parameters in the article it is necessary to construct the corresponding graphic dependences taking into account the standard sizes and bands parameters. Methodology. We consider the band conveyor with two sections: the inclined and horizontal one. It is conducted a detailed analysis of dependence of the conveyor band width and its drive power on the type of cargo, project performance, geometric dimensions and configuration of the conveyor track, using the appropriate parameter dependences constructed by the authors in previous papers. Findings. For band conveyors of this type there were constructed the graphics dependences of the band width on the parameter characterizing the project performance and the inclination angle of the track section, and on the performance at a fixed angle of inclination. Taking into account the changes in the band width with an increase in the value of project performance the graph dependences of drive power on the productivity and the inclination angle of the inclined section were built. Originality. For the first time there

  20. A Numerical Study on a Vertical-Axis Wind Turbine with Inclined Arms

    OpenAIRE

    Agostino De Marco; Domenico P. Coiro; Domenico Cucco; Fabrizio Nicolosi

    2014-01-01

    This work focuses on a particular type of vertical-axis wind turbine, in which a number of inclined arms with airfoil-shaped cross-sections are mounted to connect the principal blades to their hub. While the majority of the known studies on vertical-axis turbines is devoted to the role of principal blades, in most of the cases without taking into account other parts of the wind turbine, the objective of this work is to investigate the effect of uncommon arm geometries, such as the inclined ar...

  1. Cyclotron resonance in InAs/GaSb heterostructure in inclined magnetic field

    CERN Document Server

    Greshnov, A A; Vasilev, Yu B; Suchalkin, S D; Meltser, B Y; Ivanov, S V; Kopev, P S

    2002-01-01

    The mechanism of splitting the cyclotron resonance line in the InAs/GaSb heterostructure in the inclined magnetic field is experimentally and theoretically studied. It is shown that the electrons and holes mixing in leads to the anticrossing Landau levels and consequently to the cyclotron resonance line splitting. Splitting in the case of the inclined magnetic field was not observed which is explained by damping the electrons and holes states mixing in on the account of originating the additional barrier for the electrons and holes by availability of the magnetic field longitudinal constituent

  2. Aerodynamic coefficients of stationary dry inclined bridge cables in laminar flow

    DEFF Research Database (Denmark)

    Matteoni, Giulia; Georgakis, Christos; Ricciardelli, Francesco

    2011-01-01

    Stay cables are the most flexible elements of cable-stayed bridges. When exposed to wind loading, they often undergo large amplitude vibrations, thus motivating serious design concerns. In most cases, vibrations are observed in the presence of water rivulets or ice accretions, which lead...... to an effective change in the cable cross section, and its aerodynamic properties. On the other hand, divergent, self-excited vibrations have been observed in the field also for dry, inclined stay cables, in warm temperatures. The need for reliable design guidelines for inclined stay cables has motivated...

  3. Non-destructive automated express method for determining the inclination of chromium-nickel steels IGC

    International Nuclear Information System (INIS)

    Nazarov, A.A.; Kamenev, Yu.B.; Kuusk, L.V.; Kormin, E.G.; Vasil'ev, A.N.; Sumbaeva, T.E.

    1986-01-01

    Methods of automated control of 18-10-type steel inclination to IGC are developed and a corresponding automated testing complex (ATS) is created. 08Kh18N10T steel samples had two variants of thermal treatment: 1) 1200 deg (5 h), 600 deg (50 h); 2) 1200 deg (5 h). Methods of non-destructive automated control of 18-10-type steel inclination to IGC are developed on the basis of potentiodynamic reactivation (PR) principle. Automated testing complex is developed, which has undergone experimental running and demonstrated a high confidence of results, reliability and easy operation

  4. An analytical model for force prediction in ball nose micro milling of inclined surfaces

    DEFF Research Database (Denmark)

    Bissacco, Giuliano; Hansen, Hans Nørgaard; De Chiffre, Leonardo

    2010-01-01

    Ball nose micro milling is a key process for the generation of free form surfaces and inclined surfaces often present in mould inserts for micro replication. This paper presents a new cutting force model for ball nose micro milling that is capable of taking into account the effect of the edge rad...... radius and the effect of the surface topography due to the previous milling passes. The model is completely analytical can be applied to ball end micro milling of slanted surfaces for any value of the surface inclination angle relative to the tool axis....

  5. Minimum descent time along a set of connected inclined planes

    Science.gov (United States)

    Mungan, Carl E.; Lipscombe, Trevor C.

    2017-07-01

    The time required for a particle to slide frictionlessly down a set of ramps connected end to end can be minimized numerically as a function of the coordinates of the connection points between ramps and compared to the exact cycloidal solution of the brachistochrone problem. It is found that a set of just three joined ramps over a large range of geometrical aspect ratios has a descent time within 5% of the optimal cycloid. The special case where the particle starts and ends at the same height has sufficient symmetry that it can be analyzed analytically using algebra alone. The level of analysis is appropriate to an undergraduate classical mechanics course.

  6. Formation of Close-in Super-Earths by Giant Impacts: Effects of Initial Eccentricities and Inclinations of Protoplanets

    Energy Technology Data Exchange (ETDEWEB)

    Matsumoto, Yuji [Planetary Exploration Research Center, Chiba Institute of Technology, Narashino, Chiba, 275-0016 (Japan); Kokubo, Eiichiro, E-mail: ymatsumoto@cfca.nao.ac.jp [Center for Computational Astrophysics, National Astronomical Observatory of Japan, Osawa, Mitaka, Tokyo, 181-8588 (Japan)

    2017-07-01

    Recent observations have revealed the eccentricity and inclination distributions of close-in super-Earths. These distributions have the potential to constrain their formation processes. In the in situ formation scenario, the eccentricities and inclinations of planets are determined by gravitational scattering and collisions between protoplanets on the giant impact stage. We investigate the effect of the initial eccentricities and inclinations of protoplanets on the formation of close-in super-Earths. We perform N -body simulations of protoplanets in gas-free disks, changing the initial eccentricities and inclinations systematically. We find that while the eccentricities of protoplanets are well relaxed through their evolution, the inclinations are not. When the initial inclinations are small, they are not generally pumped up since scattering is less effective and collisions occur immediately after orbital crossing. On the other hand, when the initial inclinations are large, they tend to be kept large since collisional damping is less effective. Not only the resultant inclinations of planets, but also their number, eccentricities, angular momentum deficit, and orbital separations are affected by the initial inclinations of protoplanets.

  7. Evaluation of cell death mechanisms activated by the administration of the theranostics radiopharmaceutical 177Lu-DOTA-anti-CD20 in a dose range of 1-5 Gy

    International Nuclear Information System (INIS)

    Martinez V, B. E.

    2016-01-01

    Radio-immunotherapy with anti-CD20 antibodies significantly increases the rate of remission in patients with CD20 over expressing B-cell lymphomas. Radio-labeled antibodies directed to surface antigens allow delivering scaled doses of radiation to specific targets thus limiting the dose to healthy tissue. Anti-CD20 causes cell death by two major pathways; activating the immune system to destroy malignant cells and inducing the activation of cell death pathways. The 177 Lu is a beta particle emitter (max. 0.497 MeV) with a maximum soft tissue reach of 0.7 mm and a half-life of 6.7 days. Several clinical studies have established a maximum tolerated dose (45m Ci/m 2 ) for 177 Lu-DOTA-rituximab, which shows a favorable clinical response without hematological toxicity. However, the molecular mechanisms of synergistic activation of anti-CD20 and radionuclide have not been studied. In this work we evaluated by flow cytometry, the activation kinetics of the cell death mechanisms induced by the treatment with 177 Lu-DOTA-anti-CD20 from non-Hod king lymphoma cells (Raji). The absorbed radiation dose delivered to the cell nucleus was calculated by Monte Carlo simulation, considering the contribution of the beta emissions of the radiopharmaceutical present in the cell membrane and surrounding environment, as well as crossfire. This work shows that the application of radiation doses of 1 to 5 Gy of the radiopharmaceutical 177 Lu-DOTA-anti-CD20 are sufficient to induce cell death by apoptosis and arrest of the cell cycle. The combination of these factors (continuous delivery of radiation activation of repair mechanisms and increased radio-sensitivity) causes acute activation of the apoptotic program resulting in significant cell death after 96 h of treatment. The temporal analysis of cell death suggests the early activation of apoptosis that is counteracted by the activation of repair processes caused by sustained irradiation, which leads to cell arrest and increases

  8. Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice

    International Nuclear Information System (INIS)

    Ware, J.H.; Rusek, A.; Sanzari, J.; Avery, S.; Sayers, C.; Krigsfeld, G.; Nuth, M.; Wan, X.S.; Kennedy, A.R.

    2010-01-01

    The present study evaluated the acute effects of radiation dose, dose rate and fractionation as well as the energy of protons in hematopoietic cells of irradiated mice. The mice were irradiated with a single dose of 51.24 MeV protons at a dose of 2 Gy and a dose rate of 0.05-0.07 Gy/min or 1 GeV protons at doses of 0.1, 0.2, 0.5, 1, 1.5 and 2 Gy delivered in a single dose at dose rates of 0.05 or 0.5 Gy/min or in five daily dose fractions at a dose rate of 0.05 Gy/min. Sham-irradiated animals were used as controls. The results demonstrate a dose-dependent loss of white blood cells (WBCs) and lymphocytes by up to 61% and 72%, respectively, in mice irradiated with protons at doses up to 2 Gy. The results also demonstrate that the dose rate, fractionation pattern and energy of the proton radiation did not have significant effects on WBC and lymphocyte counts in the irradiated animals. These results suggest that the acute effects of proton radiation on WBC and lymphocyte counts are determined mainly by the radiation dose, with very little contribution from the dose rate (over the range of dose rates evaluated), fractionation and energy of the protons.

  9. Effects of proton radiation dose, dose rate and dose fractionation on hematopoietic cells in mice.

    Science.gov (United States)

    Ware, J H; Sanzari, J; Avery, S; Sayers, C; Krigsfeld, G; Nuth, M; Wan, X S; Rusek, A; Kennedy, A R

    2010-09-01

    The present study evaluated the acute effects of radiation dose, dose rate and fractionation as well as the energy of protons in hematopoietic cells of irradiated mice. The mice were irradiated with a single dose of 51.24 MeV protons at a dose of 2 Gy and a dose rate of 0.05-0.07 Gy/min or 1 GeV protons at doses of 0.1, 0.2, 0.5, 1, 1.5 and 2 Gy delivered in a single dose at dose rates of 0.05 or 0.5 Gy/min or in five daily dose fractions at a dose rate of 0.05 Gy/min. Sham-irradiated animals were used as controls. The results demonstrate a dose-dependent loss of white blood cells (WBCs) and lymphocytes by up to 61% and 72%, respectively, in mice irradiated with protons at doses up to 2 Gy. The results also demonstrate that the dose rate, fractionation pattern and energy of the proton radiation did not have significant effects on WBC and lymphocyte counts in the irradiated animals. These results suggest that the acute effects of proton radiation on WBC and lymphocyte counts are determined mainly by the radiation dose, with very little contribution from the dose rate (over the range of dose rates evaluated), fractionation and energy of the protons.

  10. Stick-slip and Torsional Friction Factors in Inclined Wellbores

    Directory of Open Access Journals (Sweden)

    Aarsnes Ulf Jakob F.

    2018-01-01

    The model is shown to have a good match with the surface and downhole behavior of two deviated wellbores for depths ranging from 1500 to 3000 meters. In particular, the model replicates the amplitude and period of the oscillations, in both the topside torque and the downhole RPM, as caused by the along-string stick slip. It is further shown that by using the surface behavior of the drill-string during rotational startup, an estimate of the static and dynamic friction factors along the wellbore can be obtained, even during stick-slip oscillations, if axial tension in the drillstring is considered. This presents a possible method to estimate friction factors in the field when off-bottom stick slip is encountered, and points in the direction of avoiding stick slip through the design of an appropriate torsional start-up procedure without the need of an explicit friction test.

  11. Dose limits

    International Nuclear Information System (INIS)

    Fitoussi, L.

    1987-12-01

    The dose limit is defined to be the level of harmfulness which must not be exceeded, so that an activity can be exercised in a regular manner without running a risk unacceptable to man and the society. The paper examines the effects of radiation categorised into stochastic and non-stochastic. Dose limits for workers and the public are discussed

  12. The Relationship between Mg ii Broad Emission and Quasar Inclination Angle

    Energy Technology Data Exchange (ETDEWEB)

    Wildy, Conor; Czerny, Bozena, E-mail: wildy@cft.edu.pl [Center for Theoretical Physics, Polish Academy of Sciences, Warsaw (Poland)

    2017-11-14

    Several observed spectral properties of quasars are believed to be influenced by quasar orientation. In this investigation we examine the effect of orientation on the Mg ii line located at 2,798 Å in a sample of 36 radio-loud quasars, with orientation angles having been obtained in a previous study using radio observations. We find no significant relationship between orientation angle and either Mg ii line full-width at half-maximum or equivalent width. The lack of correlation with inclination angle contradicts previous studies which also use radio data as a proxy for inclination angle and suggests the Mg ii emission region does not occupy a disk-like geometry. The lack of correlation with Mg ii equivalent width, however, is reported in at least one previous study. Although the significance is not very strong (86%), there is a possible negative relationship between inclination angle and Fe ii strength which, if true, could explain the Fe ii anti-correlation with [O iii] strength associated with Eigenvector 1. Interestingly, there are objects having almost edge-on inclinations while still exhibiting broad lines. This could be explained by a torus which is either clumpy (allowing sight lines to the central engine) or mis-aligned with the accretion disk.

  13. Complex network analysis in inclined oil–water two-phase flow

    International Nuclear Information System (INIS)

    Zhong-Ke, Gao; Ning-De, Jin

    2009-01-01

    Complex networks have established themselves in recent years as being particularly suitable and flexible for representing and modelling many complex natural and artificial systems. Oil–water two-phase flow is one of the most complex systems. In this paper, we use complex networks to study the inclined oil–water two-phase flow. Two different complex network construction methods are proposed to build two types of networks, i.e. the flow pattern complex network (FPCN) and fluid dynamic complex network (FDCN). Through detecting the community structure of FPCN by the community-detection algorithm based on K-means clustering, useful and interesting results are found which can be used for identifying three inclined oil–water flow patterns. To investigate the dynamic characteristics of the inclined oil–water two-phase flow, we construct 48 FDCNs under different flow conditions, and find that the power-law exponent and the network information entropy, which are sensitive to the flow pattern transition, can both characterize the nonlinear dynamics of the inclined oil–water two-phase flow. In this paper, from a new perspective, we not only introduce a complex network theory into the study of the oil–water two-phase flow but also indicate that the complex network may be a powerful tool for exploring nonlinear time series in practice. (general)

  14. On the influence of gravity on the static state of an inclined tensioned string

    NARCIS (Netherlands)

    Van Horssen, W.T.

    2004-01-01

    In this paper the static state of an inclined stretched string due to gravity is considered. The string is stretched between two fixed supports which are situated at two different levels. It is assumed that the tension in the string is suffiently large such that the sag of the string due to gravity

  15. The Relationship between Mg ii Broad Emission and Quasar Inclination Angle

    Directory of Open Access Journals (Sweden)

    Conor Wildy

    2017-11-01

    Full Text Available Several observed spectral properties of quasars are believed to be influenced by quasar orientation. In this investigation we examine the effect of orientation on the Mg ii line located at 2,798 Å in a sample of 36 radio-loud quasars, with orientation angles having been obtained in a previous study using radio observations. We find no significant relationship between orientation angle and either Mg ii line full-width at half-maximum or equivalent width. The lack of correlation with inclination angle contradicts previous studies which also use radio data as a proxy for inclination angle and suggests the Mg ii emission region does not occupy a disk-like geometry. The lack of correlation with Mg ii equivalent width, however, is reported in at least one previous study. Although the significance is not very strong (86%, there is a possible negative relationship between inclination angle and Fe ii strength which, if true, could explain the Fe ii anti-correlation with [O iii] strength associated with Eigenvector 1. Interestingly, there are objects having almost edge-on inclinations while still exhibiting broad lines. This could be explained by a torus which is either clumpy (allowing sight lines to the central engine or mis-aligned with the accretion disk.

  16. Demographic Factors, Personality and Entrepreneurial Inclination: A Study among Indian University Students

    Science.gov (United States)

    Chaudhary, Richa

    2017-01-01

    Purpose: The purpose of this paper is to investigate the influence of demographic, social and personal dispositional factors on determining the entrepreneurial inclination. Specifically, the author examined the role of gender, age, stream of study, family business background and six psychological traits of locus of control, tolerance for…

  17. Constraining the Relative Inclinations of the Planets B and C of the ...

    Indian Academy of Sciences (India)

    2016-01-27

    Jan 27, 2016 ... We investigate on the relative inclination of the planets B and C orbiting the pulsar PSR B1257+12. First, we show that the third Kepler's law does represent an adequate model for the orbital periods of the planets, because other Newtonian and Einsteinian corrections are orders of magnitude smaller than ...

  18. Effect of seat surface inclination on postural control during reaching in preterm children with cerebral palsy

    NARCIS (Netherlands)

    Hadders-Algra, Mijna; van der Heide, Jolanda C.; Fock, Johanna M.; Stremmelaar, Elisabeth; van Eykern, Leo A.; Otten, Bert

    Background and Purpose Because it is debatable whether seat surface inclination improves motor function in children with cerebral palsy (CP), the effect of seat surface tilting on postural control and quality of reaching was studied. Subjects The subjects were 58 children with CP aged 2 to 11 years

  19. The effects of porosity and angle of inclination on the deflection of ...

    African Journals Online (AJOL)

    The effects of porosity and angle of inclination on the deflection of fluid flow in porous media. ... a helpful Frequently Asked Questions about PDFs. Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

  20. Deformation of two welded elastic half-spaces due to a long inclined ...

    Indian Academy of Sciences (India)

    2Department of Mathematics, University of Delhi South Campus, New Delhi 110 021, India. ∗e-mail: ... Airy stress function for a tensile line source in two welded half-spaces are first obtained. These expressions ... computing the displacement and stress fields around a long inclined tensile fault near an internal boundary. 1.

  1. Reconstruction of inclined air showers detected with the Pierre Auger Observatory

    NARCIS (Netherlands)

    Pierre Auger Collaboration, [No Value; Aab, A.; Abreu, P.; Aglietta, M.; Ahlers, M.; Ahn, E. J.; Samarai, I. Al; Albuquerque, I. F. M.; Allekotte, I.; Allen, J.; Allison, P.; Almela, A.; Alvarez Castillo, J.; Alvarez-Muñiz, J.; Alves Batista, R.; Ambrosio, M.; Aminaei, A.; Anchordoqui, L.; Andringa, S.; Aramo, C.; Arqueros, F.; Asorey, H.; Assis, P.; Aublin, J.; Ave, M.; Avenier, M.; Avila, G.; Badescu, A. M.; Barber, K. B.; Bäuml, J.; Baus, C.; Beatty, J. J.; Becker, K. H.; Bellido, J. A.; Berat, C.; Bertou, X.; Biermann, P. L.; Billoir, P.; Blanco, F.; Blanco, M.; Bleve, C.; Blümer, H.; Boháčová, M.; Boncioli, D.; Bonifazi, C.; Bonino, R.; Borodai, N.; Brack, J.; Brancus, I.; Brogueira, P.; Brown, W. C.; Buchholz, P.; Bueno, A.; Buscemi, M.; Caballero-Mora, K. S.; Caccianiga, B.; Caccianiga, L.; Candusso, M.; Caramete, L.; Caruso, R.; Castellina, A.; Cataldi, G.; Cazon, L.; Cester, R.; Chavez, A. G.; Cheng, S. H.; Chiavassa, A.; Chinellato, J. A.; Chudoba, J.; Cilmo, M.; Clay, R. W.; Cocciolo, G.; Colalillo, R.; Collica, L.; Coluccia, M. R.; Conceição, R.; Contreras, F.; Cooper, M. J.; Coutu, S.; Covault, C. E.; Criss, A.; Cronin, J.; Curutiu, A.; Dallier, R.; Daniel, B.; Dasso, S.; Daumiller, K.; Dawson, B. R.; de Almeida, R. M.; De Domenico, M.; de Jong, S. J.; de Mello Neto, J. R. T.; De Mitri, I.; de Oliveira, J.; de Souza, V.; del Peral, L.; Deligny, O.; Dembinski, H.; Dhital, N.; Di Giulio, C.; Di Matteo, A.; Diaz, J. C.; D\\'\\iaz Castro, M. L.; Diep, P. N.; Diogo, F.; Dobrigkeit, C.; Docters, W.; D'Olivo, J. C.; Dong, P. N.; Dorofeev, A.; Dorosti Hasankiadeh, Q.; Dova, M. T.; Ebr, J.; Engel, R.; Erdmann, M.; Erfani, M.; Escobar, C. O.; Espadanal, J.; Etchegoyen, A.; Facal San Luis, P.; Falcke, H.; Fang, K.; Farrar, G.; Fauth, A. C.; Fazzini, N.; Ferguson, A. P.; Fernandes, M.; Fick, B.; Figueira, J. M.; Filevich, A.; Filipčič, A.; Fox, B. D.; Fratu, O.; Fröhlich, U.; Fuchs, B.; Fuji, T.; Gaior, R.; Garc\\'\\ia, B.; Garcia Roca, S. T.; Garcia-Gamez, D.; Garcia-Pinto, D.; Garilli, G.; Gascon Bravo, A.; Gate, F.; Gemmeke, H.; Ghia, P. L.; Giaccari, U.; Giammarchi, M.; Giller, M.; Glaser, C.; Glass, H.; Gomez Albarracin, F.; Gómez Berisso, M.; Gómez Vitale, P. F.; Gonçalves, P.; Gonzalez, J. G.; Gookin, B.; Gorgi, A.; Gorham, P.; Gouffon, P.; Grebe, S.; Griffith, N.; Grillo, A. F.; Grubb, T. D.; Guardincerri, Y.; Guarino, F.; Guedes, G. P.; Hansen, P.; Harari, D.; Harrison, T. A.; Harton, J. L.; Haungs, A.; Hebbeker, T.; Heck, D.; Heimann, P.; Herve, A. E.; Hill, G. C.; Hojvat, C.; Hollon, N.; Holt, E.; Homola, P.; Hörandel, J. R.; Horvath, P.; Hrabovský, M.; Huber, D.; Huege, T.; Insolia, A.; Isar, P. G.; Islo, K.; Jandt, I.; Jansen, S.; Jarne, C.; Josebachuili, M.; Kääpä, A.; Kambeitz, O.; Kampert, K. H.; Kasper, P.; Katkov, I.; Kégl, B.; Keilhauer, B.; Keivani, A.; Kemp, E.; Kieckhafer, R. M.; Klages, H. O.; Kleifges, M.; Kleinfeller, J.; Krause, R.; Krohm, N.; Krömer, O.; Kruppke-Hansen, D.; Kuempel, D.; Kunka, N.; La Rosa, G.; LaHurd, D.; Latronico, L.; Lauer, R.; Lauscher, M.; Lautridou, P.; Le Coz, S.; Leão, M. S. A. B.; Lebrun, D.; Lebrun, P.; Leigui de Oliveira, M. A.; Letessier-Selvon, A.; Lhenry-Yvon, I.; Link, K.; López, R.; Lopez Agëra, A.; Louedec, K.; Lozano Bahilo, J.; Lu, L.; Lucero, A.; Ludwig, M.; Lyberis, H.; Maccarone, M. C.; Malacari, M.; Maldera, S.; Maller, J.; Mandat, D.; Mantsch, P.; Mariazzi, A. G.; Marin, V.; Mariş, I. C.; Marsella, G.; Martello, D.; Martin, L.; Martinez, H.; Mart\\'\\inez Bravo, O.; Martraire, D.; Mas\\'\\ias Meza, J. J.; Mathes, H. J.; Mathys, S.; Matthews, A. J.; Matthews, J.; Matthiae, G.; Maurel, D.; Maurizio, D.; Mayotte, E.; Mazur, P. O.; Medina, C.; Medina-Tanco, G.; Melissas, M.; Melo, D.; Menichetti, E.; Menshikov, A.; Messina, S.; Meyhandan, R.; Mićanović, S.; Micheletti, M. I.; Middendorf, L.; Minaya, I. A.; Miramonti, L.; Mitrica, B.; Molina-Bueno, L.; Mollerach, S.; Monasor, M.; Monnier Ragaigne, D.; Montanet, F.; Morello, C.; Moreno, J. C.; Mostafá, M.; Moura, C. A.; Muller, M. A.; Müller, G.; Münchmeyer, M.; Mussa, R.; Navarra, G.; Navas, S.; Necesal, P.; Nellen, L.; Nelles, A.; Neuser, J.; Newton, D.; Niechciol, M.; Niemietz, L.; Niggemann, T.; Nitz, D.; Nosek, D.; Novotny, V.; Nožka, L.; Ochilo, L.; Olinto, A.; Oliveira, M.; Olmos-Gilbaja, V. M.; Ortiz, M.; Pacheco, N.; Pakk Selmi-Dei, D.; Palatka, M.; Pallotta, J.; Palmieri, N.; Papenbreer, P.; Parente, G.; Parra, A.; Pastor, S.; Paul, T.; Pech, M.; Pȩkala, J.; Pelayo, R.; Pepe, I. M.; Perrone, L.; Pesce, R.; Petermann, E.; Peters, C.; Petrera, S.; Petrolini, A.; Petrov, Y.; Piegaia, R.; Pierog, T.; Pieroni, P.; Pimenta, M.; Pirronello, V.; Platino, M.; Plum, M.; Porcelli, A.; Porowski, C.; Privitera, P.; Prouza, M.; Purrello, V.; Quel, E. J.; Querchfeld, S.; Quinn, S.; Rautenberg, J.; Ravel, O.; Ravignani, D.; Revenu, B.; Ridky, J.; Riggi, S.; Risse, M.; Ristori, P.; Rizi, V.; Roberts, J.; Rodrigues de Carvalho, W.; Rodriguez Cabo, I.; Rodriguez Fernandez, G.; Rodriguez Rojo, J.; Rodr\\'\\iguez-Fr\\'\\ias, M. D.; Ros, G.; Rosado, J.; Rossler, T.; Roth, M.; Roulet, E.; Rovero, A. C.; Rühle, C.; Saffi, S. J.; Saftoiu, A.; Salamida, F.; Salazar, H.; Salesa Greus, F.; Salina, G.; Sánchez, F.; Sanchez-Lucas, P.; Santo, C. E.; Santos, E.; Santos, E. M.; Sarazin, F.; Sarkar, B.; Sarmento, R.; Sato, R.; Scharf, N.; Scherini, V.; Schieler, H.; Schiffer, P.; Schmidt, A.; Scholten, O.; Schoorlemmer, H.; Schovánek, P.; Schulz, A.; Schulz, J.; Sciutto, S. J.; Segreto, A.; Settimo, M.; Shadkam, A.; Shellard, R. C.; Sidelnik, I.; Sigl, G.; Sima, O.; Śmiał kowski, A.; Šm\\'\\ida, R.; Snow, G. R.; Sommers, P.; Sorokin, J.; Squartini, R.; Srivastava, Y. N.; Stanič, S.; Stapleton, J.; Stasielak, J.; Stephan, M.; Stutz, A.; Suarez, F.; Suomijärvi, T.; Supanitsky, A. D.; Sutherland, M. S.; Swain, J.; Szadkowski, Z.; Szuba, M.; Taborda, O. A.; Tapia, A.; Tartare, M.; Thao, N. T.; Theodoro, V. M.; Tiffenberg, J.; Timmermans, C.; Todero Peixoto, C. J.; Toma, G.; Tomankova, L.; Tomé, B.; Tonachini, A.; Torralba Elipe, G.; Torres Machado, D.; Travnicek, P.; Trovato, E.; Tueros, M.; Ulrich, R.; Unger, M.; Urban, M.; Valdés Galicia, J. F.; Valiño, I.; Valore, L.; van Aar, G.; van den Berg, A. M.; van Velzen, S.; van Vliet, A.; Varela, E.; Vargas Cárdenas, B.; Varner, G.; Vázquez, J. R.; Vázquez, R. A.; Veberič, D.; Verzi, V.; Vicha, J.; Videla, M.; Villaseñor, L.; Vlcek, B.; Vorobiov, S.; Wahlberg, H.; Wainberg, O.; Walz, D.; Watson, A. A.; Weber, M.; Weidenhaupt, K.; Weindl, A.; Werner, F.; Whelan, B. J.; Widom, A.; Wiencke, L.; Wilczyńska, B.; Wilczyński, H.; Will, M.; Williams, C.; Winchen, T.; Wittkowski, D.; Wundheiler, B.; Wykes, S.; Yamamoto, T.; Yapici, T.; Younk, P.; Yuan, G.; Yushkov, A.; Zamorano, B.; Zas, E.; Zavrtanik, D.; Zavrtanik, M.; Zaw, I.; Zepeda, A.; Zhou, J.; Zhu, Y.; Zimbres Silva, M.; Ziolkowski, M.

    2014-01-01

    We describe the method devised to reconstruct inclined cosmic-ray air showers with zenith angles greater than 60° detected with the surface array of the Pierre Auger Observatory. The measured signals at the ground level are fitted to muon density distributions predicted with atmospheric cascade

  2. Effect of dual task type on gait and dynamic stability during stair negotiation at different inclinations

    NARCIS (Netherlands)

    Madehkhaksar, F.; Egges, J.

    Stair gait is a common daily activity with great potential risk for falls. Stairs have varying inclinations and people may perform other tasks concurrently with stair gait. This study investigated dual-task interference in the context of complex gait tasks, such as stair gait at different

  3. EFFECT OF BRIDGE PIERS INCLINATION AND ROUGHNESS ON SCOUR PIT DIMENSIONS

    Directory of Open Access Journals (Sweden)

    Moaed S. Khalil

    2013-05-01

    Full Text Available In this paper a laboratory work was performed to study the effect of bridge piers inclination and surface roughness on scour pit dimensions. Fifty four experiments were conducted using three different sizes and inclinations Pier models fixed in a sandy bed channel. First, the axis of the pier was parallel to the flow, then it was inclined by 30° and finally by 45°. Each model was tested under three different flow discharges for a period not less than two hours and at the end of each experiment the dimensions of the scour pit were measured. The same experiments were repeated after roughening the surface of each pier by fine gravel of 2mm in diameter to increase its roughness.The results of the experiment showed a clear reduction in scour pit dimensions after increasing pier roughness, the percentage of decreases in scour depth was between 2 % and 61%, while the scour length decreased between 2.5% and 22%, and finally the width of scour decreases was between 3% and 19.7%. The results also showed that the inclination of pier's axis produced an increase in scour pit dimensions. Finally, the empirical relationships of the results showed that it's possible to explain the relation between the flow discharge and each of scour pit dimensions by a simple linear equation, where the determination coefficient were more than 0.94 for all relations. 

  4. First Measurements of the Inclined Boron Layer Thermal-Neutron Detector for Reflectometry

    Energy Technology Data Exchange (ETDEWEB)

    Clonts, Lloyd G [ORNL; Crow, Lowell [ORNL; Van Vuure, Thorwald L [ORNL; Robertson, Lee [ORNL; Riedel, Richard A [ORNL; Richards, John D [ORNL; Cooper, Ronald G [ORNL; Remec, Igor [ORNL; Ankner, John Francis [ORNL; Browning, Jim [ORNL

    2010-01-01

    A prototype detector based on the inclined boron layer principle is introduced. For typical measurement conditions at the Liquids Reflectometer at the Spallation Neutron Source, its count rate capability is shown to be superior to that of the current detector by nearly two orders of magnitude.

  5. The Racing-Game Effect : Why Do Video Racing Games Increase Risk-Taking Inclinations?

    NARCIS (Netherlands)

    Fischer, Peter; Greitemeyer, Tobias; Morton, Thomas; Kastenmueller, Andreas; Postmes, Tom; Frey, Dieter; Kubitzki, Joerg; Odenwaelder, Joerg; Kastenmüller, A.; Odenwälder, J.

    2009-01-01

    The present studies investigated why video racing games increase players' risk-taking inclinations. Four studies reveal that playing video racing games increases risk taking in a subsequent simulated road traffic situation, as well as risk-promoting cognitions and emotions, blood pressure, sensation

  6. A Study of Static Performance of Fixed Inclined Slider Bearings – A ...

    African Journals Online (AJOL)

    In this paper, the performance of a fixed inclined slider bearing whose surfaces are lubricated by a non Newtonian power law lubricant is investigated numerically. Based on the power law model, the modified Reynolds equation is derived and solved using the finite element method. The effect of flow index on pressure ...

  7. The effects of porosity and angle of inclination on the deflection of ...

    African Journals Online (AJOL)

    -section of soils in deflecting contaminated fluid from septic tank to different directions from the source of water within the same small portion of land. It was observed that angle of inclination does not have a significant effect on the deflection of ...

  8. Second law analysis of a solar air heater having 60° inclined ...

    African Journals Online (AJOL)

    Artificially roughened solar air heaters perform better than the smooth ones under the same operating conditions. However, artificial roughness leads to even more fluid pressure thereby increasing the pumping power. The entropy generation in the duct of solar air heater having 60° inclined discrete rib roughness on one ...

  9. A Numerical Study on a Vertical-Axis Wind Turbine with Inclined Arms

    Directory of Open Access Journals (Sweden)

    Agostino De Marco

    2014-01-01

    Full Text Available This work focuses on a particular type of vertical-axis wind turbine, in which a number of inclined arms with airfoil-shaped cross-sections are mounted to connect the principal blades to their hub. While the majority of the known studies on vertical-axis turbines is devoted to the role of principal blades, in most of the cases without taking into account other parts of the wind turbine, the objective of this work is to investigate the effect of uncommon arm geometries, such as the inclined arms. The inclined arms are known to have a potentially beneficial role in the power extraction from the wind current but, due to the complexity of the phenomena, the investigation on aerodynamics of this type of turbine is often impossible through analytical models, such as blade-element momentum theory. It turns out that adequate studies can only be carried out by wind tunnel experiments or CFD simulations. This work presents a methodical CFD study on how inclined arms can be used on a selected wind turbine configuration to harvest additional power from the wind. The turbine configuration, geometry, and some fundamental definitions are introduced first. Then an in-depth CFD analysis is presented and discussed.

  10. Exact solution of cilia induced flow of a Jeffrey fluid in an inclined tube.

    Science.gov (United States)

    Maqbool, K; Shaheen, S; Mann, A B

    2016-01-01

    The present study investigated the cilia induced flow of MHD Jeffrey fluid through an inclined tube. This study is carried out under the assumptions of long wavelength and low Reynolds number approximations. Exact solutions for the velocity profile, pressure rise, pressure gradient, volume flow rate and stream function are obtained. Effects of pertinent physical parameters on the computational results are presented graphically.

  11. Mitigation of Traffic-Induced Ground Vibration by Inclined Wave Barriers

    DEFF Research Database (Denmark)

    Andersen, Lars; Augustesen, Anders Hust

    2009-01-01

    Double sheet pile walls can be used as wave barriers in order to mitigate ground vibrations from railways. The present analysis concerns the efficiency of such barriers, especially with regard to the influence of the barrier inclination and the backfill between the walls. Thus, the screening...

  12. The Effect of Multi-inclined Holes on the Creep Properties of Nickel-Based Superalloy

    Science.gov (United States)

    Li, Dongfan; Wen, Zhixun; Wang, Shaofei; Liu, Chenyu; Yue, Zhufeng

    2017-07-01

    The creep properties of GH3536 nickel-based superalloy plate specimens without/with multi-inclined holes were studied under applied stress 80/90/100 MPa at 850 °, respectively. Interesting finding is focused on the inflection point, that is, both the fraction elongation and creep strain achieve the maximum value under 90 MPa. Further study is carried out by two methods: the finite element analysis (FEA) calculation and scanning electron microscope (SEM). The FEA results show that the dangerous areas appear in the regions near the end of ellipse axis along the inclined angle orientation, which is similar to the actual fracture appearances. What is more, the tiny holes and dimples are the main characters of creep fracture for multi-inclined hole specimens, whereas the creep fracture of specimens without holes is the result of growth and coalescence of voids. In addition, based on creep performance, laser drilling is better than that of the electric spark drilling, which provides a proof that the creep performance of specimens with multi-inclined holes will be better with the improvement of the drilling process.

  13. Is Mandibular Fossa Morphology and Articular Eminence Inclination Associated with Temporomandibular Dysfunction?

    Science.gov (United States)

    Paknahad, Maryam; Shahidi, Shoaleh; Akhlaghian, Marzieh; Abolvardi, Masoud

    2016-06-01

    Finding a significant relationship between temporomandibular joint (TMJ) morphology and the incidence of temporomandibular dysfunction (TMD) may help early prediction and prevention of these problems. The purpose of the present study was to determine the morphology of mandibular fossa and the articular eminence inclination in patients with TMD and in control group using cone beam computed tomography (CBCT). The CBCT data of bilateral TMJs of 40 patients with TMD and 23 symptom-free cases were evaluated. The articular eminence inclination, as well as the glenoid fossa depth and width of the mandibular fossa were measured. The paired t-test was used to compare these values between two groups. The articular eminence inclination and glenoid fossa width and depth were significantly higher in patients with TMD than in the control group (p < 0.05). The articular eminence inclination was steeper in patients with TMD than in the control group. Glenoid fossa width and depth were higher in patients with TMD than that in the control group. This information may shed light on the relationship between TMJ morphology and the incidence of TMD.

  14. Effect of inclined ribs on heat transfer coefficient in stationary square channel

    Directory of Open Access Journals (Sweden)

    Natthaporn Kaewchoothong

    2017-11-01

    Full Text Available The main objective of this research is to study the effect of rib arrangement on the distributions of the local heat transfer coefficient in a stationary channel. In this study, the ribs with square cross section were used to place on two side walls for study. The rib height-to-hydraulic diameter ratio (e/D h and the rib pitch-to-height (p/e ratio were fixed at 0.133 and 10, respectively. Three different types of rib arrangement for inclined ribs, V-shaped ribs and inverted V-shaped ribs were investigated. The rib angle of attack (α was varied from 30° to 90° for inclined ribs and 45° and 60° for both V-shaped and inverted V-shaped ribs, and compared at constant Reynolds number Re =30000. Thermal Liquid Crystal sheet was applied for evaluating the heat transfer distributions. The results showed that the average Nusselt number on surface with rib inclined angle at 60°, 45°, and 60° V-shaped ribs was improved up to about 20%, 25% and 30% higher than case of angle 90° and the rib inclined angle at 60° V-shaped ribs provided the highest Nusselt number covering largest area when compared to the other cases.

  15. Gibberellin mediates the development of gelatinous fibres in the tension wood of inclined Acacia mangium seedlings.

    Science.gov (United States)

    Nugroho, Widyanto Dwi; Nakaba, Satoshi; Yamagishi, Yusuke; Begum, Shahanara; Marsoem, Sri Nugroho; Ko, Jae-Heung; Jin, Hyun-O; Funada, Ryo

    2013-11-01

    Gibberellin stimulates negative gravitropism and the formation of tension wood in tilted Acacia mangium seedlings, while inhibitors of gibberellin synthesis strongly inhibit the return to vertical growth and suppress the formation of tension wood. To characterize the role of gibberellin in tension wood formation and gravitropism, this study investigated the role of gibberellin in the development of gelatinous fibres and in the changes in anatomical characteristics of woody elements in Acacia mangium seedlings exposed to a gravitational stimulus. Gibberellin, paclobutrazol and uniconazole-P were applied to the soil in which seedlings were growing, using distilled water as the control. Three days after the start of treatment, seedlings were inclined at 45 ° to the vertical and samples were harvested 2 months later. The effects of the treatments on wood fibres, vessel elements and ray parenchyma cells were analysed in tension wood in the upper part of inclined stems and in the opposite wood on the lower side of inclined stems. Application of paclobutrazol or uniconazole-P inhibited the increase in the thickness of gelatinous layers and prevented the elongation of gelatinous fibres in the tension wood of inclined stems. By contrast, gibberellin stimulated the elongation of these fibres. Application of gibberellin and inhibitors of gibberellin biosynthesis had only minor effects on the anatomical characteristics of vessel and ray parenchyma cells. The results suggest that gibberellin is important for the development of gelatinous fibres in the tension wood of A. mangium seedlings and therefore in gravitropism.

  16. Experimental studies on circular and AR4 elliptic vortex-ring impingement upon inclined surfaces

    Science.gov (United States)

    Shi, Shengxian; New, Tze How; Chen, Jian

    2014-11-01

    PLIF flow visualisation and TR-PIV measurements were performed on the impingement of circular and AR4 elliptic vortex-rings upon flat surface with different inclination angles at Re = 4000. This is aimed to investigate the effects of nozzle geometry, surface inclination angle and exit-surface separation distance on the vortex-ring impingement behaviour. Separation distance between nozzle exit and flat surface were adjusted for the elliptic vortex-ring so as to examine the flow structures for impingement prior, at and posterior the axis-switching point. Current results on circular vortex-ring show that at low inclination angle, vortex-ring underwent severe stretching during the impingement and vortex-ring core closer to the flat surface was observed to induce secondary vortex-ring and pair with it before its pinch-off. Meanwhile, vortex-ring core further away from the flat surface produced secondary and tertiary vortex-rings before transit into turbulence. At high inclination angles, vortex-ring core closer to the flat surface was quickly entrained by the primary vortex-ring after the impingement. Experiments on elliptic vortex-ring are undergoing at the moment, more findings will be presented in the conference.

  17. Effects of turbulence and flow inclination on the performance of cup anemometers in the field

    DEFF Research Database (Denmark)

    Papadopoulos, K.H.; Stefantos, N.C.; Schmidt Paulsen, U.

    2001-01-01

    Four commercial and one research cup anemometers were comparatively tested in a complex terrain site to quantify the effects of turbulence and flow inclination on the wind speed measurements. The difference of the mean wind speed reading between the anemometers was as much as 2% for wind directio...

  18. Changes of occlusal plane inclination after orthodontic treatment in different dentoskeletal frames.

    Science.gov (United States)

    Li, Jin-le; Kau, Chung; Wang, Min

    2014-06-25

    The inclination of the occlusal plane (OP) is related to facial types and experiences physiological growth-related changes. The aims of this research were to determine if there were any differences in the inclination of OP in subjects with three types of skeletal malocclusion and to investigate the characteristics and differences of functional occlusal plane (FOP) compared to bisected occlusal plane (BOP). A sample of 90 Caucasians patients was skeletal-classified into three (n = 30), and pre- and post-treatment cephalograms were digitized. Six linear and 8 angular cephalometric measurements were selected. The changes of OP inclination within each group and the differences among the three groups pre- and post-treatment were compared with paired t test and ANOVA test, respectively. The comparison and correlation between BOP and FOP were analyzed with paired t test and coefficient of correlation, respectively. The BOP angle increased in all of the three groups but only had statistically significant differences in skeletal class II patients in a mean of 1.51° (p stability (p > 0.05) in all three groups. The inclination of FOP was closely related to that of BOP (p stability in orthodontically treated patients with all three skeletal patterns.

  19. Experimental investigation of coarse particles-water mixture flow in horizontal and inclined pipes

    Czech Academy of Sciences Publication Activity Database

    Vlasák, Pavel; Chára, Zdeněk; Krupička, Jan; Konfršt, Jiří

    2014-01-01

    Roč. 62, č. 3 (2014), s. 241-247 ISSN 0042-790X R&D Projects: GA ČR GAP105/10/1574 Institutional support: RVO:67985874 Keywords : hydraulic pipelining * coarse-grained slurry * pressure drops * pipe inclination * concentration distribution Subject RIV: BK - Fluid Dynamics Impact factor: 1.486, year: 2014

  20. Articular Eminence Inclination, Height, and Condyle Morphology on Cone Beam Computed Tomography

    Directory of Open Access Journals (Sweden)

    Dilhan İlgüy

    2014-01-01

    Full Text Available Aim. The aim of the present study was to examine the relationship between articular eminence inclination, height, and thickness of the roof of the glenoid fossa (RGF according to age and gender and to assess condyle morphology including incidental findings of osseous characteristics associated with osteoarthritis (OA of the temporomandibular joint (TMJ using cone beam computed tomography (CBCT. Materials and Methods. CBCT images of 105 patients were evaluated retrospectively. For articular eminence inclination and height, axial views on which the condylar processes were seen with their widest mediolateral extent being used as a reference view for secondary reconstruction. Condyle morphology was categorized both in the sagittal and coronal plane. Results. The mean values of eminence inclination and height of males were higher than those of females (P<0.05. There were significant differences in the RGF thickness in relation to sagittal condyle morphology. Among the group of OA, the mean value of the RGF thickness for “OA-osteophyte” group was the highest (1.59 mm, whereas the lowest RGF values were seen in the “OA-flattening.” Conclusion. The sagittal osteoarthritic changes may have an effect on RGF thickness by mechanical stimulation and changed stress distribution. Gender has a significant effect on eminence height (Eh and inclination.

  1. Rapid prototyping and inclined plane technique in the treatment of maxillofacial malformations in a fox

    Science.gov (United States)

    Freitas, Elisangela P.; Rahal, Sheila C.; Teixeira, Carlos R.; Silva, Jorge V.L.; Noritomi, Pedro Y.; Villela, Carlos H.S.; Yamashita, Seizo

    2010-01-01

    An approximately 9-month-old fox (Pseudalopex vetulus) was presented with malocclusion and deviation of the lower jaw to the right side. Orthodontic treatment was performed using the inclined plane technique. Virtual 3D models and prototypes of the head were based on computed tomography (CT) image data to assist in diagnosis and treatment. PMID:20514249

  2. Impact of cusp inclinations on dental fractures in cracked tooth syndrome model and relevant risk evaluation.

    Science.gov (United States)

    Xie, Nina; Wang, Penglai; Wu, Cui; Song, Wenting; Wang, Wen; Liu, Zongxiang

    2017-12-01

    We explored the impact of cusp inclinations on dental fractures in cracked tooth syndrome model and formulated corresponding risk scale. Forty maxillary premolars were randomized into four groups for cusp inclination measurements by digital radiovisiography (RVG). For cracked tooth models, buccal and palatal cusp inclinations were achieved by grinding in groups I (59°-50°), II (64°-55°) and III (69°-60°), with group IV as blank control. All groups underwent compression loading test, with fracture levels recorded for statistical analysis. The fracture modes included a majority of crown root fractures and a minority of crown fractures in groups I and II, exclusive crown root fractures in group III, and exclusive crown fractures in group IV. Overall, palatal fractures were predominant versus buccal fractures, with exclusive palatal fractures in group IV, and oblique fractures were overwhelming versus the scanty vertical fractures. Fracture risk classification: grade III was prevalent in groups I and II, grade IV in group III, and grades I and II in group IV only. The fracture risk scores in groups III and IV had significant statistical differences versus groups I and II (P0.05). Cracked teeth are more vulnerable to complex fractures, with increment of cusp inclinations contributable to complex fracture modes, involving deep roots and high risk scores.

  3. Average course approximation of measured subsidence and inclinations of mining area by smooth splines

    Directory of Open Access Journals (Sweden)

    Justyna Orwat

    2017-01-01

    Full Text Available The results of marking average courses of subsidence measured on the points of measuring line no. 1 of the “Budryk” Hard Coal Mine, set approximately perpendicularly to a face run of four consecutively mined longwalls in coal bed 338/2 have been presented in the article. Smooth splines were used to approximate the average course of measured subsidence after subsequent exploitation stages. The minimising of the sum of the squared differences between the average and forecasted subsidence, using J. Bialek's formula, was used as a selection criterion of parameter values of smoothing an approximating function. The parameter values of this formula have been chosen in order to match forecasted subsidence with measured ones. The average values of inclinations have been calculated on the basis of approximated values of observed subsidence. It has been shown that by doing this the average values of extreme measured inclinations can be obtained in almost the same way as extreme observed inclinations. It is not necessary to divide the whole profile of a subsidence basin into parts. The obtained values of variability coefficients of a random scattering for subsidence and inclinations are smaller than their values which occur in the literature.

  4. Biomimetic walking trajectory generation of humanoid robot on an inclined surface using Fourier series.

    Science.gov (United States)

    Park, Ill-Woo; Kim, Jung-Yup

    2014-10-01

    This article describes a novel method to generate a biomimetic walking trajectory for a biped humanoid robot on an inclined surface. We assume that the configuration of the inclined surface is known, and we solve the human-like walking trajectory generation problem by obtaining the solution from the desired zero moment point (ZMP) trajectory to the center of gravity (CoG) trajectory. We present an analytic solution for the walking trajectory generation by using Fourier series. From the given ZMP trajectory biomimetically represented by the Fourier series, we focus on how to find the CoG trajectory in an analytical way. A time-segmentation based approach is adopted for generating the trajectories. The trajectory functions need to be continuous between the segments; thus, the solution is found by calculating the coefficients under these connectivity conditions. We derive a general form of the ZMP equation using a simple inverted pendulum model (SIPM), which includes the ZMP and the CoG trajectories in the horizontal and vertical directions to quantify the walking parameters on the inclined surface. The performance of the proposed approach is verified by conducting walking simulations using a full-body dynamic simulator on three different inclined surfaces and comparing them to the authors' previous approach.

  5. Investigation on novel raceway pond with inclined paddle wheels through simulation and microalgae culture experiments.

    Science.gov (United States)

    Zeng, Fanxue; Huang, Jianke; Meng, Chen; Zhu, Fachao; Chen, Jianpei; Li, Yuanguang

    2016-01-01

    The open raceway ponds are nowadays the most used large-scale reactors for microalgae culture. To avoid the stacking of microalgae, the paddle wheels are the most widely used to circulate and mix the culture medium. In this paper, a numerical simulation using computational fluid dynamics (CFD) was used to investigate the hydrodynamic characteristics of open raceway ponds with different types of paddle wheels (the traditional paddle wheels and the novel paddle wheels with specially inclined angle of the blades). The particle image velocimetry (PIV) was used to validate the reliability of the CFD model. The CFD simulation results showed that the novel raceway pond with 15° inclined angle of the blades had the best mixing efficiency under the same power consumption. Lastly, the results of microalgae culture experiments showed that the growth rates of Chlorella pyrenoidosa in the novel raceway pond with 15° inclined angle of the blades were higher than those in the traditional reactor. The results of the culture experiments and CFD simulations were identical with each other. Therefore, a novel paddle wheel with 15° inclined angle of the blades was obtained for better microalgae cultivation.

  6. Pelvic tilt and truncal inclination: two key radiographic parameters in the setting of adults with spinal deformity.

    Science.gov (United States)

    Lafage, Virginie; Schwab, Frank; Patel, Ashish; Hawkinson, Nicola; Farcy, Jean-Pierre

    2009-08-01

    Prospective radiographic and clinical analysis. Investigate the relationship between spino-pelvic parameters and patient self reported outcomes on adult subjects with spinal deformities. It is becoming increasingly recognized that the study of spinal alignment should include pelvic position. While pelvic incidence determines lumbar lordosis, pelvic tilt (PT) is a positional parameter reflecting compensation to spinal deformity. Correlation between plumbline offset (sagittal vertical axis [SVA]) and Health Related Quality of Life (HRQOL) measures has been demonstrated, but such a study is lacking for PT. This prospective study was carried out on 125 adult patients suffering from spinal deformity (mean age: 57 years). Full-length free-standing radiographs including the spine and pelvis were available for all patients. HRQOL instruments included: Oswestry Disability Index, Short Form-12, Scoliosis Research Society. Correlation analysis between radiographic spinopelvic parameters and HRQOL measures was pursued. Correlation analysis revealed no significance pertaining to coronal plane parameters. Significant sagittal plane correlations were identified. SVA and truncal inclination measured by T1 spinopelvic inclination (T1-SPI) (angle between T1-hip axis and vertical) correlated with: Scoliosis Research Society (appearance, activity, total score), Oswestry Disability Index, and Short Form-12 (physical component score). Correlation coefficients ranged from 0.42 < r < 0.55 (P < 0.0001). T1-SPI revealed greater correlation with HRQOL compared to SVA. PT showed correlation with HRQOL (0.28 < r < 0.42) and with SVA (r = 0.64, P < 0.0001). This study confirms that pelvic position measured via PT correlates with HRQOL in the setting of adult deformity. High values of PT express compensatory pelvic retroversion for sagittal spinal malalignment. This study also demonstrates significant T1-SPI correlation with HRQOL measures and outperforms SVA. This parameter carries the

  7. Inclined Jet in Crossflow Interacting with a Vortex Generator

    Science.gov (United States)

    Zaman, K. B. M. Q.; Rigby, D .L.; Heidmann, J. D.

    2011-01-01

    An experiment is conducted on the effectiveness of a vortex generator in preventing liftoff of a jet in crossflow, with possible relevance to film-cooling applications. The jet issues into the boundary layer at an angle of 20 degreees to the freestream. The effect of a triangular ramp-shaped vortex generator is studied while varying its geometry and location. Detailed flowfield properties are obtained for a case in which the height of the vortex generator and the diameter of the orifice are comparable with the approach boundary-layer thickness. The vortex generator produces a streamwise vortex pair with a vorticity magnitude 3 times larger (and of opposite sense) than that found in the jet in crossflow alone. Such a vortex generator appears to be most effective in keeping the jet attached to the wall. The effect of parametric variation is studied mostly from surveys 10 diameters downstream from the orifice. Results over a range of jet-to-freestream momentum flux ratio (1 vortex generator has a significant effect even at the highest J covered in the experiment. When the vortex generator height is halved, there is a liftoff of the jet. On the other hand, when the height is doubled, the jet core is dissipated due to larger turbulence intensity. Varying the location of the vortex generator, over a distance of three diameters from the orifice, is found to have little impact. Rounding off the edges of the vortex generator with the increasing radius of curvature progressively diminishes its effect. However, allowing for a small radius of curvature may be quite tolerable in practice.

  8. A Phase I Study of Light Dose for Photodynamic Therapy (PDT) Using 2-[1-hexyloxyethyl]-2 devinyl Pyropheophorbide-a (HPPH) for Treatment of Non-small Cell Carcinoma in situ or Non-small Cell Microinvasive Bronchogenic Carcinoma. A Dose Ranging Study

    Science.gov (United States)

    Dhillon, Samjot Singh; Demmy, Todd L.; Yendamuri, Sai; Loewen, Gregory; Nwogu, Chukwumere; Cooper, Michele; Henderson, Barbara W.

    2015-01-01

    Introduction We report a phase I trial of photodynamic therapy (PDT) of carcinoma-insitu (CIS) and microinvasive cancer (MIC) of the central airways with the photosensitizer (PS) 2-[1-hexyloxyethyl]-2-devinyl pyropheophorbide-a (HPPH). HPPH has the advantage of minimal general phototoxicity over the commonly used PS porfimer sodium (Photofrin®). Methods The objectives of this study were 1) to determine the maximally tolerated light dose at a fixed PS dose and 2) to gain initial insight into the effectiveness of this treatment approach. Seventeen patients with 21 CIS/MIC lesions were treated with HPPH with light dose escalation starting from 75 J/cm2 to 85, 95,125, and 150 J/cm2 respectively. Follow-up bronchoscopy for response assessment was done at one and six months, respectively. Results The rate of pathological complete response (CR) was 82.4% (14/17 evaluable lesions; 14 patients) at one-month and 72.7% (8/11 lesions; 8 patients) at 6 months. Only 4 patients developed mild skin erythema. One of the three patients in 150 J/cm2 light dose group experienced a serious adverse event. This patient had respiratory distress due to mucus plugging, which precipitated cardiac ischemia. Two additional patients treated subsequently at this light dose had no adverse events. The third sixth patient in this dose group was not recruited and the study was terminated because of delays in HPPH supply. However, given the observed serious adverse event, it is recommended that the light dose not exceed 125J/cm2. Conclusions PDT with HPPH can be safely used for the treatment of CIS/MIC of the airways, with potential effectiveness comparable to that reported for porfimer sodium in earlier studies. PMID:26718878

  9. Simulation of Flow Pattern around Inclined Bridge Group Pier using FLOW-3D Software

    Directory of Open Access Journals (Sweden)

    Malihesadat Jafari

    2017-03-01

    Full Text Available Introduction: Bridges are certainly one of the most important structures but costly service elements in a transport system. The bridges are very required to access the damaged areas in emergency situations such as floods and earthquakes. Scour around the foundations of bridge piers exposed to the flowing water than can destroy the bridge itself is a subject of major concern. Flow pattern is known as responsible for all changes in stream bed. Any obstacle in the channel can form new flow patterns causing additional shear stress exerted on the bed than the equilibrium condition of the absence of the obstacle. Appropriate shaping of flow pattern and proper selecting of pier geometry and the location of bridge piers can be one of the proper methods in reduction of scour amount which is the main subject of the present study. Materials and Methods: Inclined bridge group pier is a type of bridges with modern geometry based on development in building technology of structures. Many of these bridges have been built all around the world and the 8th bridge built crossing the Karun River in Ahvaz is a sample of the Iranian ones considered in this research. Hydrodynamic behavior of flow is investigated around the inclined bridge group pier settled on foundation using the FLOW-3D numerical model. Inclined bridge group pier investigated in this study, includes two rectangular piers which are 2.5 cm long and 3.5 cm wide and set in an angle of 28 degree on rectangular foundation which is 16 cm long and 10 cm wide and installed in three different foundation levels namely at, above and below the bed levels. The physical model of prototype pier considered in this study was constructed to the scale of 1:190 of the Ahvaz 8th bridge. In order to verify the accuracy of the numerical model, velocity data obtained from image processing technique were used. Results and Discussion: Due to non- linearity and interactions between various phenomena involved, flow pattern

  10. Influence of thread shape and inclination on the biomechanical behaviour of plateau implant systems.

    Science.gov (United States)

    Calì, Michele; Zanetti, Elisabetta Maria; Oliveri, Salvatore Massimo; Asero, Riccardo; Ciaramella, Stefano; Martorelli, Massimo; Bignardi, Cristina

    2018-03-01

    To assess the influence of implant thread shape and inclination on the mechanical behaviour of bone-implant systems. The study assesses which factors influence the initial and full osseointegration stages. Point clouds of the original implant were created using a non-contact reverse engineering technique. A 3D tessellated surface was created using Geomagic Studio ® software. From cross-section curves, generated by intersecting the tessellated model and cutting-planes, a 3D parametric CAD model was created using SolidWorks ® 2017. By the permutation of three thread shapes (rectangular, 30° trapezoidal, 45° trapezoidal) and three thread inclinations (0°, 3° or 6°), nine geometric configurations were obtained. Two different osseointegration stages were analysed: the initial osseointegration and a full osseointegration. In total, 18 different FE models were analysed and two load conditions were applied to each model. The mechanical behaviour of the models was analysed by Finite Element (FE) Analysis using ANSYS ® v. 17.0. Static linear analyses were also carried out. ANOVA was used to assess the influence of each factor. Models with a rectangular thread and 6° inclination provided the best results and reduced displacement in the initial osseointegration stages up to 4.58%. This configuration also reduced equivalent VM stress peaks up to 54%. The same effect was confirmed for the full osseointegration stage, where 6° inclination reduced stress peaks by up to 62%. The FE analysis confirmed the beneficial effect of thread inclination, reducing the displacement in immediate post-operative conditions and equivalent VM stress peaks. Thread shape does not significantly influence the mechanical behaviour of bone-implant systems but contributes to reducing stress peaks in the trabecular bone in both the initial and full osseointegration stages. Copyright © 2018 The Academy of Dental Materials. Published by Elsevier Ltd. All rights reserved.

  11. Compact Planetary Systems Perturbed by an Inclined Companion. II. Stellar Spin-Orbit Evolution

    Science.gov (United States)

    Boué, Gwenaël; Fabrycky, Daniel C.

    2014-07-01

    The stellar spin orientation relative to the orbital planes of multiplanet systems is becoming accessible to observations. Here, we analyze and classify different types of spin-orbit evolution in compact multiplanet systems perturbed by an inclined outer companion. Our study is based on classical secular theory, using a vectorial approach developed in a separate paper. When planet-planet perturbations are truncated at the second order in eccentricity and mutual inclination, and the planet-companion perturbations are developed at the quadrupole order, the problem becomes integrable. The motion is composed of a uniform precession of the whole system around the total angular momentum, and in the rotating frame, the evolution is periodic. Here, we focus on the relative motion associated with the oscillations of the inclination between the planet system and the outer orbit and of the obliquities of the star with respect to the two orbital planes. The solution is obtained using a powerful geometric method. With this technique, we identify four different regimes characterized by the nutation amplitude of the stellar spin axis relative to the orbital plane of the planets. In particular, the obliquity of the star reaches its maximum when the system is in the Cassini regime where planets have more angular momentum than the star and where the precession rate of the star is similar to that of the planets induced by the companion. In that case, spin-orbit oscillations exceed twice the inclination between the planets and the companion. Even if the mutual inclination is only ~= 20°, this resonant case can cause the spin-orbit angle to oscillate between perfectly aligned and retrograde values.

  12. Finding the Acceleration and Speed of a Light-Emitting Object on an Inclined Plane with a Smartphone Light Sensor

    Science.gov (United States)

    Kapucu, Serkan

    2017-01-01

    This study investigates how the acceleration and speed of a light-emitting object on an inclined plane may be determined using a smartphone's light sensor. A light-emitting object was released from the top of an inclined plane and its illuminance values were detected by a smartphone's light sensor during its subsequent motion down the plane. Using…

  13. Controllable dose

    International Nuclear Information System (INIS)

    Alvarez R, J.T.; Anaya M, R.A.

    2004-01-01

    With the purpose of eliminating the controversy about the lineal hypothesis without threshold which found the systems of dose limitation of the recommendations of ICRP 26 and 60, at the end of last decade R. Clarke president of the ICRP proposed the concept of Controllable Dose: as the dose or dose sum that an individual receives from a particular source which can be reasonably controllable by means of any means; said concept proposes a change in the philosophy of the radiological protection of its concern by social approaches to an individual focus. In this work a panorama of the foundations is presented, convenient and inconveniences that this proposal has loosened in the international community of the radiological protection, with the purpose of to familiarize to our Mexican community in radiological protection with these new concepts. (Author)

  14. Testing correction for paleomagnetic inclination error in sedimentary rocks: a comparative approach

    Science.gov (United States)

    Tauxe, L.; Kodama, K. P.; Kent, D. V.

    2008-05-01

    Paleomagnetic inclinations in sedimentary formations are frequently suspected of being too shallow. Recognition and correction of shallow bias is therefore critical for paleogeographical reconstructions. The elongation/inclination (E/I) correction method of Tauxe and Kent (2004) relies on the twin assumptions that inclination flattening follows the empirical sedimentary flattening formula and that the distribution of paleomagnetic directions can be predicted from a paleosecular variation (PSV) model. We will test the reliability of the E/I correction method in several ways. First we consider the E/I trends predicted by various PSV models. The Giant Gaussian Process-type paleosecular variation models were all constrained by paleomagnetic data from lava flows of the last five million years. Therefore, to test whether the method can be used in more ancient times, we will compare model predictions of E/I trends with observations from four Large Igneous Provinces since the Jurassic (Yemen, Kerguelen, Faroe Islands, and Deccan basalts). All data are consistent at the 95% level of confidence with the elongation/inclination trends predicted by the paleosecular variation models. Then we will then discuss the geological implications of various applications of the E/I method. In general the E/I corrected data are more consistent with data from contemporaneous lavas, with predictions from the well constrained synthetic apparent polar wander paths, and other geological constraints. Finally, we will compare the E/I corrections with corrections from an entirely different method of inclination correction: the anisotropy of remanence method of Jackson et al. (1991) which relies on measurement of remanence and particle anisotropies of the sediments. In the two cases where a direct comparison can be made, the two methods give corrections that are consistent within error. In summary, it appears that the elongation/inclination method for recognizing and corrected the effects of

  15. Monte Carlo simulations of dose distribution in water phantom for monoenergetic photon sources in the energy range of 20 keV and 2 MeV using a customized GEANT4 distribution

    International Nuclear Information System (INIS)

    Heredia, Eduardo; Rodrigues Jr, Orlando; Campos, Leticia Lucente

    2008-01-01

    Full text: Monte Carlo simulation methods are important tools in the areas of radiation transport and dosimetry, assisting in the radiation therapy treatment planning, study of energy deposition in complex systems and aid in the agreement the experimental results in the research of new materials. However, two aspects can affect the use of these tools: complexity in real world problems transposition to the simulation environment and difficulty in computational codes utilization. The objective of this work is to present a free software distribution based in the GEANT4 Monte Carlo code. The distribution was customized with the addition of tools for the development, visualization and data analysis in a software package with simplified installation and attended configuration. A wizard tool was developed and incorporated to the software package aiming to assist the user in the simulation skeleton creation and the election of the compilation and link flags for new models of simulation in the area of the radiation dosimetry. This software distribution is part of a wider project for the development of an infrastructure based in the GEANT4 for the radiation transport simulation under the perspective of a non centered computational architecture in dosimetry. The absorbed dose distribution in water phantom was simulated for monoenergetic photon sources with energies between 20 keV and 2 MeV. All results and analyses were generated with the tools incorporated in the software package. (author)

  16. The difference between standing and sitting in 3 different seat inclinations on abdominal muscle activity and chest and abdominal expansion in woodwind and brass musicians.

    Science.gov (United States)

    Ackermann, Bronwen J; O'Dwyer, Nicholas; Halaki, Mark

    2014-01-01

    Wind instrumentalists require a sophisticated functioning of their respiratory system to control their air stream, which provides the power for optimal musical performance. The air supply must be delivered into the instrument in a steady and controlled manner and with enough power by the action of the expiratory musculature to produce the desired level of sound at the correct pitch. It is suggested that playing posture may have an impact on the abdominal muscle activity controlling this expired air, but there is no research on musicians to support this theory. This study evaluated chest and abdominal expansion, via respiratory inductive plethysmography, as well as activation patterns of lower and upper abdominal musculature, using surface electromyography, during performance of a range of typical orchestral repertoire by 113 woodwind and brass players. Each of the five orchestral excerpts was played in one of four randomly allocated postures: standing; sitting flat; sitting inclined forwards; and sitting inclined backwards. Musicians showed a clear preference for playing in standing rather than sitting. In standing, the chest expansion range and maximum values were greater (p abdominal expansion was less than in all sitting postures (p abdominal expansion was reduced in the forward inclined posture compared to the other sitting postures (p abdominal muscle activation between the sitting postures, but the level of activation in sitting was only 2/3 of the significantly higher level observed in standing (p < 0.01). This study has demonstrated significant differences in respiratory mechanics between sitting and standing postures in wind musicians during playing of typical orchestral repertoire. Further research is needed to clarify the complex respiratory mechanisms supporting musical performance.

  17. The difference between standing and sitting in 3 different seat inclinations on abdominal muscle activity and chest and abdominal expansion in woodwind and brass musicians

    Directory of Open Access Journals (Sweden)

    Bronwen Jane Ackermann

    2014-08-01

    Full Text Available Wind instrumentalists require a sophisticated functioning of their respiratory system to control their air stream, which provides the power for optimal musical performance. The air supply must be delivered into the instrument in a steady and controlled manner and with enough power by the action of the expiratory musculature to produce the desired level of sound at the correct pitch. It is suggested that playing posture may have an impact on the abdominal muscle activity controlling this expired air, but there is no research on musicians to support this theory. This study evaluated chest and abdominal expansion, via respiratory inductive plethysmography, as well as activation patterns of lower and upper abdominal musculature, using surface electromyography, during performance of a range of typical orchestral repertoire by 113 woodwind and brass players. Each of the five orchestral excerpts was played in one of four randomly allocated postures: standing; sitting flat; sitting inclined forwards; and sitting inclined backwards.Musicians showed a clear preference for playing in standing rather than sitting. In standing, the chest expansion range and maximum values were greater (p<0.01, while the abdominal expansion was less than in all sitting postures (p<0.01. Chest expansion patterns did not vary between the three sitting postures, while abdominal expansion was reduced in the forward inclined posture compared to the other sitting postures (p<0.05. There was no significant variation in abdominal muscle activation between the sitting postures, but the level of activation in sitting was only 2/3 of the significantly higher level observed in standing (p<0.01.This study has demonstrated significant differences in respiratory mechanics between sitting and standing postures in wind musicians during playing of typical orchestral repertoire. Further research is needed to clarify the complex respiratory mechanisms supporting musical performance.

  18. Aesthetically Inclined.

    Science.gov (United States)

    Newman, Mark A.

    2002-01-01

    Describes the new Ford Building at Detroit's College for Creative Studies. The building's design is intended to "inspire future artisans" with its open setting incorporating flexible space and natural light. Includes photographs and information on suppliers. (EV)

  19. Oblique Wave-Induced Responses of A VLFS Edged with A Pair of Inclined Perforated Plates

    Science.gov (United States)

    Cheng, Yong; Ji, Chun-yan; Zhai, Gang-jun; Oleg, Gaidai

    2018-03-01

    This paper is concerned with the hydroelastic responses of a mat-like, rectangular very large floating structure (VLFS) edged with a pair of horizontal/inclined perforated anti-motion plates in the context of the direct coupling method. The updated Lagrangian formulae are applied to establish the equilibrium equations of the VLFS and the total potential formula is employed for fluids in the numerical model including the viscous effect of the perforated plates through the Darcy's law. The hybrid finite element-boundary element (FE-BE) method is implemented to determine the response reduction of VLFS with attached perforated plates under various oblique incident waves. Also, the numerical solutions are validated against a series of experimental tests. The effectiveness of the attached perforated plates in reducing the deflections of the VLFS can be significantly improved by selecting the proper design parameters such as the porous parameter, submergence depth, plate width and inclination angle for the given sea conditions.

  20. Role of edge inclination in an optical microdisk resonator for label-free sensing.

    Science.gov (United States)

    Gandolfi, Davide; Ramiro-Manzano, Fernando; Rebollo, Francisco Javier Aparicio; Ghulinyan, Mher; Pucker, Georg; Pavesi, Lorenzo

    2015-02-26

    In this paper, we report on the measurement and modeling of enhanced optical refractometric sensors based on whispering gallery modes. The devices under test are optical microresonators made of silicon nitride on silicon oxide, which differ in their sidewall inclination angle. In our approach, these microresonators are vertically coupled to a buried waveguide with the aim of creating integrated and cost-effective devices. Device modeling shows that the optimization of the device is a delicate balance of the resonance quality factor and evanescent field overlap with the surrounding environment to analyze. By numerical simulations, we show that the microdisk thickness is critical to yield a high figure of merit for the sensor and that edge inclination should be kept as high as possible. We also show that bulk-sensing figures of merit as high as 1600 RIU(-1) (refractive index unit) are feasible.

  1. Reconstruction of inclined air showers detected with the Pierre Auger Observatory

    Energy Technology Data Exchange (ETDEWEB)

    collaboration, The Pierre Augur

    2014-08-01

    We describe the method devised to reconstruct inclined cosmic-ray air showers with zenith angles greater than 60° detected with the surface array of the Pierre Auger Observatory. The measured signals at the ground level are fitted to muon density distributions predicted with atmospheric cascade models to obtain the relative shower size as an overall normalization parameter. The method is evaluated using simulated showers to test its performance. The energy of the cosmic rays is calibrated using a sub-sample of events reconstructed with both the fluorescence and surface array techniques. The reconstruction method described here provides the basis of complementary analyses including an independent measurement of the energy spectrum of ultra-high energy cosmic rays using very inclined events collected by the Pierre Auger Observatory.

  2. Impact of inclined magnetic field on micropolar Casson fluid using Keller box algorithm

    Science.gov (United States)

    Iqbal, Z.; Mehmood, R.; Azhar, Ehtsham; Mehmood, Zaffar

    2017-04-01

    The present study examines the influence of an inclined magnetic field on a micropolar Casson fluid flow over a stretching sheet. Viscous dissipation effects are also taken into consideration. The governing physical problem is presented using the traditional Navier-Stokes theory. By means of the scaling group of transformation, a consequential system of equations is transformed into a set of nonlinear ordinary differential equations which are then solved using the implicit finite-difference approximation (Keller box method). The working fluid is examined for several sundry parameters graphically and in tabular form. It is observed that with an increase in inclination angle, the velocity profile decreases while temperature enhances. The Eckert number enhances flow velocity and temperature, whereas it decreases shear stress at the wall and heat transfer rate. The rheological fluid parameter contributes to the decline of velocity and temperature for weak as well as strong concentrations of micro elements.

  3. Spectrum of 100-kyr glacial cycle: Orbital inclination, not eccentricity

    Science.gov (United States)

    Muller, Richard A.; MacDonald, Gordon J.

    1997-01-01

    Spectral analysis of climate data shows a strong narrow peak with period ≈100 kyr, attributed by the Milankovitch theory to changes in the eccentricity of the earth’s orbit. The narrowness of the peak does suggest an astronomical origin; however the shape of the peak is incompatible with both linear and nonlinear models that attribute the cycle to eccentricity or (equivalently) to the envelope of the precession. In contrast, the orbital inclination parameter gives a good match to both the spectrum and bispectrum of the climate data. Extraterrestrial accretion from meteoroids or interplanetary dust is proposed as a mechanism that could link inclination to climate, and experimental tests are described that could prove or disprove this hypothesis. PMID:11607741

  4. Magnetohydrodynamics Carreau nanofluid flow over an inclined convective heated stretching cylinder with Joule heating

    Directory of Open Access Journals (Sweden)

    Imad Khan

    Full Text Available Current work highlights the computational aspects of MHD Carreau nanofluid flow over an inclined stretching cylinder with convective boundary conditions and Joule heating. The mathematical modeling of physical problem yields nonlinear set of partial differential equations. A suitable scaling group of variables is employed on modeled equations to convert them into non-dimensional form. The integration scheme Runge-Kutta-Fehlberg on the behalf of shooting technique is utilized to solve attained set of equations. The interesting aspects of physical problem (linear momentum, energy and nanoparticles concentration are elaborated under the different parametric conditions through graphical and tabular manners. Additionally, the quantities (local skin friction coefficient, local Nusselt number and local Sherwood number which are responsible to dig out the physical phenomena in the vicinity of stretched surface are computed and delineated by varying controlling flow parameters. Keywords: MHD, Carreau nanofluid, Inclined stretching cylinder, Joule heating, Shooting technique

  5. The Bearing Capacity of Strip Footings in Cohesionless Soil Subject to Eccentric and Inclined Loads

    DEFF Research Database (Denmark)

    Krabbenhøft, Sven; Damkilde, Lars; Krabbenhøft, Kristian

    2014-01-01

    the Mohr-Coulomb failure criterion. The results are reported as graphs showing the bearing capacity as a function of the friction angle, the eccentricity, inclination and the surcharge. The results have been compared with the Eurocode 7 and for smaller eccentricities, except in the case of no surcharge......Lower bound calculations based on the finite element method is used to determine the bearing capacity of a strip foundation subjected to an inclined, eccentric load on cohesionless soil with varying surcharges and with friction angles 25, 30 and 35°. The soil is assumed perfectly plastic following...... and especially for small friction angles and great surcharges the Eurocode values are considerably greater than the LB values....

  6. Effect of magnetic field on Blasius and Sakiadis flow of nanofluids past an inclined plate

    Directory of Open Access Journals (Sweden)

    S.P. Anjali Devi

    2017-11-01

    Full Text Available A theoretical study on the effect of magnetic field on the classical Blasius and Sakiadis flow of nanofluids over an inclined plate is presented in this paper. The governing partial differential equations are converted into ordinary differential equations using suitable similarity transformations. The transformed boundary layer equations are solved numerically using MATLAB (bvp4c. Two types of nanoparticles are chosen namely copper and alumina in the base fluid of water with the Prandtl number (Pr = 6.2. The effects of the governing physical parameters over the velocity, temperature, skin friction coefficient and reduced Nusselt number for both the Blasius and Sakiadis flows are displayed graphically. The characteristics of physical and engineering interest are discussed in detail. Keywords: Nanofluid, Blasius flow, Sakiadis flow, MHD, Inclined plate, Mixed convection

  7. Computation of coupled surface radiation and natural convection in an inclined form cavity

    International Nuclear Information System (INIS)

    Amraqui, Samir; Mezrhab, Ahmed; Abid, Cherifa

    2011-01-01

    The present paper is concerned with computation of the radiation-natural convection interactions in an inclined form cavity. The cavity contains two symmetrically identical isothermal blocks and is vented by two opening located in a vertical median axis at the top and the bottom parts of the cavity. Calculations are made by using a finite volume method and an efficient numerical procedure is introduced for calculating the view factors, with shadow effects included. Effects of Rayleigh number Ra and inclination angle φ are investigated for Pr = 0.71 in presence and in absence of the radiation exchange. Results are reported in terms of isotherms, streamlines, local and average Nusselt numbers and mass flow rate. In light of the obtained results, we can conclude that the heat transfer decreases with increasing φ. In addition, the increase of Ra and the taking into account of the radiation exchange produce a considerable increase in the heat transfer.

  8. A comparative numerical study on natural convection in inclined wavy and flat-plate solar collectors

    Energy Technology Data Exchange (ETDEWEB)

    Varol, Yasin [Department of Mechanical Education, Firat University, 23119 Elazig (Turkey); Oztop, Hakan F. [Department of Mechanical Engineering, Firat University, 23119 Elazig (Turkey)

    2008-09-15

    The present study deals with the numerical analysis of natural convection heat transfer inside the inclined solar collectors. Two collectors are compared. In the first case, the collector has wavy absorber and in the second case, it has flat absorber. The solution was performed assuming the isothermal boundary conditions of absorbers and covers of collectors. CFDRC commercial software is used to simulate the laminar flow and thermal field. Governing parameters are taken as Rayleigh number (from 1 x 10{sup 6} to 5 x 10{sup 7}), inclination angle (from 20 to 60 ), wave length (from 1.33 to 4) and aspect ratio (from 0 to 4). Results are presented by streamlines, isotherms and local and mean Nusselt numbers. It is observed that flow and thermal fields are affected by the shape of enclosure and heat transfer rate increases in the case of wavy enclosure than that of flat enclosure. (author)

  9. MHD boundary layer flow and heat transfer in an inclined porous square cavity filled with nanofluids

    Directory of Open Access Journals (Sweden)

    Chandra Shekar Balla

    2017-06-01

    Full Text Available The present paper deals with the magnetohydrodynamic boundary layer flow of a free convection heat transfer in an inclined square cavity filled with nanofluid-saturated porous medium. The effects of different nanoparticles Cu, Al2O3, TiO2 and SiO2 are considered. The top and bottom horizontal walls of cavity are considered adiabatic, while the vertical walls are kept at constant temperatures. The governing partial differential equations are solved by finite element method of Galerkin weighted residual scheme. Numerical results are obtained for different values of the Rayleigh number, angle of inclination, magnetic field and nanofluid volume fraction. The overall investigation of variation of streamlines, isotherms and Nusselt numbers is presented graphically. To examine the accuracy, the present results are compared with the available results.

  10. MHD natural convection in an inclined square porous cavity with a heat conducting solid block

    Science.gov (United States)

    Sivaraj, C.; Sheremet, M. A.

    2017-03-01

    This paper deals with natural convection in an inclined porous cavity with a heat conducting solid body placed at its center under the influence of the applied magnetic field of different orientations. The left and right vertical walls of the cavity are maintained at different temperatures Th and Tc, respectively, while the horizontal walls are adiabatic. The governing coupled partial differential equations were solved using a finite volume method on a uniformly staggered grid system. The effects of the inclination angles of the magnetic field and cavity and the Hartmann number on the flow and thermal fields are investigated in detail. Numerical results are presented in terms of isotherms, streamlines and average Nusselt numbers. In general, the results indicate that the inclusion of the magnetic field reduces the convective heat transfer rate in the cavity. It is also found that an increase in the angle of the applied magnetic field produces a non-linear variation in the average Nusselt numbers.

  11. Simulation on Natural Convection of a Nanofluid along an Isothermal Inclined Plate

    Science.gov (United States)

    Mitra, Asish

    2017-08-01

    A numerical algorithm is presented for studying laminar natural convection flow of a nanofluid along an isothermal inclined plate. By means of similarity transformation, the original nonlinear partial differential equations of flow are transformed to a set of nonlinear ordinary differential equations. Subsequently they are reduced to a first order system and integrated using Newton Raphson and adaptive Runge-Kutta methods. The computer codes are developed for this numerical analysis in Matlab environment. Dimensionless velocity, temperature profiles and nanoparticle concentration for various angles of inclination are illustrated graphically. The effects of Prandtl number, Brownian motion parameter and thermophoresis parameter on Nusselt number are also discussed. The results of the present simulation are then compared with previous one available in literature with good agreement.

  12. Microscopic calculation of the sticking force for nanodrops on an inclined surface

    Science.gov (United States)

    Berim, Gersh O.; Ruckenstein, Eli

    2008-09-01

    A two-dimensional nanodrop on a vertical rough solid surface is examined using a nonlocal density functional theory in the presence of gravity. The roughness is modeled either as a chemical inhomogeneity of the solid or as a result of the decoration with pillars of a smooth homogeneous surface. From the obtained fluid density distribution, the sticking force, which opposes the drop motion along an inclined surface, and the contact angles on the lower and upper leading edges of the drop are calculated. On the basis of these results, it is shown that the macroscopically derived equation for a drop in equilibrium on an inclined surface is also applicable to nanodrops. The liquid-vapor surface tension involved in this equation was calculated for various specific cases, and the values obtained are of the same order of magnitude as those obtained in macroscopic experiments.

  13. Inclinations to Conformity as a Potential Social Limit of Giftedness Development

    Directory of Open Access Journals (Sweden)

    Ilona Kočvarová

    2017-04-01

    Full Text Available The article deals with the problem of gifted pupils´ conformity, which may form a social barrier to their development during school teaching. The aim of the research is to analyse the inclination to conformity of gifted pupils during the application of differentiated enriching curriculum. The research sample consists of 86 diagnosed gifted pupils from the level of education ISCED2. The research instrument is semantically differentially based on the principle of the tool ATER. The study results suggest non-conformal inclinations of gifted pupils, which are subjectively declared in relation to the five statements describing work on a task during the application of differentiated enriching curriculum in school lessons.

  14. Robotic complex for the development of thick steeply-inclined coal seams and ore deposits

    Science.gov (United States)

    Nikitenko, M. S.; Malakhov, Yu V.; Neogi, Biswarup; Chakraborty, Pritam; Banerjee, Dipesu

    2017-09-01

    Proposal for the formulation of robotic complexes for steeply inclined coal seams as a basis of the supportive-enclosing walking module and power support with a controlled outlet for mining industry has been represented in this literature. In mining industry, the available resource base reserves and mineral deposits are concentrated deep down the earth crust leading towards a complicated geological condition i.e. abrupt ore bedding and steeply inclined strata with the high gas content and fire hazard of thick coal stratum, heading against an unfavorable and sometimes human labor life risk during subversive mining. Prevailing towards the development of effective robotic complexes based on the means of “unmanned technologies” for extraction of minerals from hard-to-reach deposits and make sure the safety of underground staff during sublevel mining technology.

  15. Flow Over Backward Facing Step with Inclined Wall Solved by Finite Volume and Finite Element Method

    Science.gov (United States)

    Louda, Petr; Sváček, Petr; Kozel, Karel; Příhoda, Jaromír

    2010-09-01

    The work deals with numerical solution of 2D incompressible flow over backward facing step. The inclination angles of the upper wall of the channel were chosen as in measurements by Driver and Seegmiller [1]. Two numerical methods are considered. One is finite volume method, the other one is finite element method. Turbulence is modeled using two-equation turbulence models of k-ω type. The influence of outlet boundary condition is discussed and do-nothing-like condition found suitable also for finite volume method. The comparison of both methods is presented for laminar as well as turbulent cases, including experimental results. The differences of the results are studied using one turbulence model and both numerical methods or one method and more turbulence models. It is found that sensitivity of the computation to these circumstances increases for higher inclination angles (diffuser flow).

  16. Studies from Cassini's high-inclination orbits: ion cyclotron wave belt

    Science.gov (United States)

    Leisner, J. S.; Russell, C. T.; Dougherty, M. K.; Persoon, A. M.; Blanco-Cano, X.; Strangeway, R. J.; Cowee, M. M.

    2007-08-01

    Surrounding Saturn is a cloud of neutral water-group molecules. When these particles are ionized and accelerated by Saturn's corotating magnetized plasma, they generate ion cyclotron waves. When the inclination of the Cassini spacecraft's orbits rose to about fifty-five degrees in late 2006, new insights into the behavior of these ion cyclotron waves were obtained as the spacecraft passed through the equatorial plane, revealing latitudinal structure of the wave belt. Centered at the magnetic equator the wave amplitude grows with height in either direction, reaching a maximum at +/- 0.2 Rs and then decreasing until they disappear by +/- 0.3 Rs. Doppler shifts caused by the motion of the spacecraft reveal that these waves propagate primarily away from the equatorial plane. Using these high-inclination orbits, we study the wave growth and damping regions and their propagation characteristics. These properties give insight into the structure and ionization of Saturn's water cloud.

  17. Hydrodynamic and thermal mechanisms of filtration combustion inclinational instability based on non-uniform distribution of initial preheating temperature

    Science.gov (United States)

    Xia, Yongfang; Shi, Junrui; Xu, Youning; Ma, Rui

    2018-03-01

    Filtration combustion (FC) is one style of porous media combustion with inert matrix, in which the combustion wave front propagates, only downstream or reciprocally. In this paper, we investigate the FC flame front inclinational instability of lean methane/air mixtures flowing through a packed bed as a combustion wave front perturbation of the initial preheating temperature non-uniformity is assumed. The predicted results show that the growth rate of the flame front inclinational angle is proportional to the magnitude of the initial preheating temperature difference. Additionally, depending on gas inlet gas velocity and equivalence ratio, it is demonstrated that increase of gas inlet gas velocity accelerates the FC wave front deformation, and the inclinational instability evolves faster at lower equivalence ratio. The development of the flame front inclinational angle may be regarded as a two-staged evolution, which includes rapid increase, and approaching maximum value of inclinational angle due to the quasi-steady condition of the combustion system. The hydrodynamic and thermal mechanisms of the FC inclinational instability are analyzed. Consequently, the local propagation velocity of the FC wave front is non-uniform to result in the development of inclinational angle at the first stage of rapid increase.

  18. Irreversibility analysis for gravity driven non-Newtonian liquid film along an inclined isothermal plate

    International Nuclear Information System (INIS)

    Makinde, O.D.

    2005-10-01

    In this paper, the first and second law of thermodynamics are employed in order to study the inherent irreversibility for a gravity driven non-Newtonian Ostwald-de Waele power law liquid film along an inclined isothermal plate. Based on some simplified assumptions, the governing equations are obtained and solved analytically. Expressions for fluid velocity, temperature, volumetric entropy generation numbers, irreversibility distribution ratio and the Bejan number are also determined. (author)

  19. Role of Edge Inclination in an Optical Microdisk Resonator for Label-Free Sensing

    OpenAIRE

    Gandolfi, Davide; Ramiro-Manzano, Fernando; Rebollo, Francisco Javier Aparicio; Ghulinyan, Mher; Pucker, Georg; Pavesi, Lorenzo

    2015-01-01

    In this paper, we report on the measurement and modeling of enhanced optical refractometric sensors based on whispering gallery modes. The devices under test are optical microresonators made of silicon nitride on silicon oxide, which differ in their sidewall inclination angle. In our approach, these microresonators are vertically coupled to a buried waveguide with the aim of creating integrated and cost-effective devices. Device modeling shows that the optimization of the devic...

  20. Comparison of Plantar Pressure Distribution between Different Speed and Incline During Treadmill Jogging.

    Science.gov (United States)

    Ho, I-Ju; Hou, Yi-You; Yang, Chich-Haung; Wu, Wen-Lan; Chen, Sheng-Kai; Guo, Lan-Yuen

    2010-01-01

    The aim of this study was to examine the effect of changes in speed and incline slope on plantar pressure distribution of the foot during treadmill jogging. Plantar pressure parameters were measured with the Pedar-X system in twenty healthy girls (mean age of 20.7 years, mean height of 1.60m, and a mean weight of 53.35kg). Because variations in walking speed or slope can significantly change the magnitude of plantar pressure, comparisons of plantar pressure distribution between the two independent protocols during treadmill jogging were considered in this study. First, the subjects ran at the same speed of 2 m·s(-1) with different incline slopes of 0%, 5%, 10%, and 15%. Second, they ran on the same slope of 0% with different speeds of 1.5 m·s(-1), 2.0 m·s(-1), and 2.5 m·s(-1). The peak pressure of the eight plantar surface areas, apart from the medial forefoot and the hallux, significantly increased (p jogging were associated with changes in plantar pressures. By systematic investigation of foot kinematics and plantar pressure during jogging with varying incline slope and speed, the results of this study provided further insight into foot biomechanics during jogging. Key pointsThe study aimed to compare the plantar pressure distribution of the foot between different incline and speed during treadmill jogging by using plantar insole measurement system.With the increase of speed, apart from the hallux and medical forefoot, the peak pressure of all regions was raised significantly.As the slope increased, there was reduced peak pressure of the heel, medial forefoot, and hallux and toes.

  1. Influence of Initial Inclined Surface Crack on Estimated Residual Fatigue Lifetime of Railway Axle

    Czech Academy of Sciences Publication Activity Database

    Náhlík, Luboš; Pokorný, Pavel; Ševčík, Martin; Hutař, Pavel

    2016-01-01

    Roč. 7, č. 4 (2016), č. článku 1640007. ISSN 1756-9737. [FDM 2016 - International Conference on Fracture and Damage Mechanics /15./. Alicante, 14.09.2016-16.09.2016] R&D Projects: GA MŠk LM2015069; GA MŠk(CZ) ED1.1.00/02.0068 Institutional support: RVO:68081723 Keywords : inclined crack * railway axle * residual fatigue lifetime * fatigue crack propagation Subject RIV: JL - Materials Fatigue, Friction Mechanics

  2. CORRELATION BETWEEN PRONATED FOOT AND PELVIC INCLINATION, FEMORAL ANTEVERSION, QUADRICEPS ANGLE AND TIBIAL TORSION

    Directory of Open Access Journals (Sweden)

    Nishita Gandhi

    2017-08-01

    Full Text Available Background: A pronated foot can produce changes in the lower limb kinetic chain. This can affect the gait and increase energy expenditure. However, the relationship between pronated foot and other static alignment factors remains poorly understood. Hence, the objective was to correlate pronated foot with pelvic inclination, femoral anteversion, Q-angle and tibial torsion. Method: An observational study was performed on 60 subjects in the age group of 18-30 years with a BMI of not more than 30. Foot Posture Index was performed on the subjects, and people with a score of +6 or more were selected. Pelvic inclination, femoral anteversion, Q-angle and tibial torsion were measured. Correlation between the Foot Posture Index score and the above four static alignment factors was done using Graph Pad Prism 7 (Pearson’s correlation coefficient and Spearman’s correlation coefficient. Results: There was no significant correlation between Pronated foot and Pelvic inclination (r-value = 0.03309, p-value = 0.8018, Pronated foot and Femoral anteversion (r-value = 0.2185, p-value = 0.0934 Pronated foot and Q-angle (r-value = 0.1801, p-value = 0.1685, Pronated foot and Tibial torsion (r- value = -0.1285, p-value = 0.3277. Conclusion: There is no significant correlation between foot pronation and pelvic inclination, femoral anteversion, Q-angle and tibial torsion. However, the correlation between these factors cannot be completely ignored, and thus, further studies and literature are required to prove the same.

  3. MHD boundary layer flow and heat transfer in an inclined porous square cavity filled with nanofluids

    OpenAIRE

    Chandra Shekar Balla; Naikoti Kishan; Rama S.R. Gorla; B.J. Gireesha

    2017-01-01

    The present paper deals with the magnetohydrodynamic boundary layer flow of a free convection heat transfer in an inclined square cavity filled with nanofluid-saturated porous medium. The effects of different nanoparticles Cu, Al2O3, TiO2 and SiO2 are considered. The top and bottom horizontal walls of cavity are considered adiabatic, while the vertical walls are kept at constant temperatures. The governing partial differential equations are solved by finite element method of Galerkin weighted...

  4. Inclined periodic homoclinic breather and rogue waves for the (1+1 ...

    Indian Academy of Sciences (India)

    [8], financial markets [9] and other related fields. The first-order .... where p1, p, α, β, b1 and b2 are real constants to be determined. Computing D2 .... β t. ) +γ = 0 with period 2π/p. So this solution is called the inclined periodic homoclinic breather solution. Using eq. (10) and taking b2 = 1, γ = ln(. √ b2) = 0 in u2. So, solution ...

  5. Probing Disk Stratification by Combining X-ray and Disk Inclination Data for Taurus-Auriga

    Science.gov (United States)

    Arraki, Kenza S.; Daly, B.; Harding, M.; McCleary, J.; Cox, A. W.; Grady, C. A.; Woodgate, B. E.; Hamaguchi, K.; Wisniewski, J. P.; Brakken-Thal, S.; Hilton, G.; Bonfield, D.; Williger, G. M.

    2010-01-01

    Photoelectric neutral Hydrogen absorption, N(H), is a probe of the gas and dust column towards the star. Kastner et al. (2005) found a correlation between N(H) and proplyd aspect ratio in the Orion nebula cluster. We extend this study to Taurus-Auriga by combining publicly available N(H) data from the XMM-Newton Extended Survey of the Taurus molecular cloud (XEST), with published disk inclination data obtained from HST coronagraphic imagery and mm interferometry. Additional inclinations were derived from jet proper motion and radial velocity data obtained from archival HST imagery and the Apache Point Observatory 3.5m telescope's Goddard Fabry-Perot and DIS long-slit spectrograph. Both N(H) and extinction have linear relations with system inclination, where the extinction has a smaller slope than the N(H) trend. Correlations with system inclination demonstrate that the bulk of both N(H) and extinction arise in the disk rather than in remnant envelopes, nearby molecular cloud material, or foreground material. The deficit in extinction compared with predictions for ISM-like gas to dust ratios is consistent with grain growth and settling toward the disk midplane and stratification in disks occurring by 2 Myr. However, the disks remain gas-rich, indicating that giant planet formation is still feasible. We gratefully acknowledge the support of the NASA Motivating Undergraduates in Science and Technology (MUST) Project and of NASA's APRA program under WBS#399131.02.06.02.32. A grant of Director's Discretionary Time funded observing time at the Apache Point Observatory.

  6. The new Permian-Triassic paleomagnetic pole for the East European Platform corrected for inclination shallowing

    Science.gov (United States)

    Fetisova, A. M.; Veselovskiy, R. V.; Scholze, F.; Balabanov, Yu. P.

    2018-01-01

    The results of detailed paleomagnetic studies in seven Upper Permian and Lower Triassic reference sections of East Europe (Middle Volga and Orenburg region) and Central Germany are presented. For each section, the coefficient of inclination shallowing f (King, 1955) is estimated by the Elongation-Inclination (E-I) method (Tauxe and Kent, 2004) and is found to vary from 0.4 to 0.9. The paleomagnetic directions, corrected for the inclination shallowing, are used to calculate the new Late Permian-Early Triassic paleomagnetic pole for the East European Platform (N = 7, PLat = 52.1°, PLong = 155.8°, A95 = 6.6°). Based on this pole, the geocentric axial dipole hypothesis close to the Paleozoic/Mesozoic boundary is tested by the single plate method. The absence of the statistically significant distinction between the obtained pole and the average Permian-Triassic (P-Tr) paleomagnetic pole of the Siberian Platform and the coeval pole of the North American Platform corrected for the opening of the Atlantic (Shatsillo et al., 2006) is interpreted by us as evidence that 250 Ma the configuration of the magnetic field of the Earth was predominantly dipolar; i.e., the contribution of nondipole components was at most 10% of the main magnetic field. In our opinion, the hypothesis of the nondipolity of the geomagnetic field at the P-Tr boundary, which has been repeatedly discussed in recent decades (Van der Voo and Torsvik, 2001; Bazhenov and Shatsillo, 2010; Veselovskiy and Pavlov, 2006), resulted from disregarding the effect of inclination shallowing in the paleomagnetic determinations from sedimentary rocks of "stable" Europe (the East European platform and West European plate).

  7. The Racing-Game Effect: Why Do Video Racing Games Increase Risk-Taking Inclinations?

    OpenAIRE

    Fischer, Peter; Greitemeyer, Tobias; Morton, Thomas; Kastenmüller, Andreas; Postmes, Tom; Frey, Dieter; Kubitzki, Jörg; Odenwälder, Jörg

    2009-01-01

    The present studies investigated why video racing games increase players’ risk-taking inclinations. Four studies reveal that playing video racing games increases risk taking in a subsequent simulated road traffic situation, as well as risk-promoting cognitions and emotions, blood pressure,sensation seeking, and attitudes toward reckless driving. Study 1 ruled out the role of experimental demand in creating such effects. Studies 2 and 3 showed that the effect of playing video racing games on r...

  8. Flow behaviour and local concentration of coarse particles-water mixture in inclined pipes

    Czech Academy of Sciences Publication Activity Database

    Vlasák, Pavel; Chára, Zdeněk; Konfršt, Jiří

    2017-01-01

    Roč. 65, č. 2 (2017), s. 183-191 ISSN 0042-790X R&D Projects: GA ČR GAP105/10/1574 Institutional support: RVO:67985874 Keywords : coarse particle mixture * concentration distribution * effect of pipe inclination * gamma-ray radiometry * Hydraulic conveying * mixture flow behaviour Subject RIV: BK - Fluid Dynamics OBOR OECD: Fluids and plasma physics (including surface physics) Impact factor: 1.654, year: 2016

  9. Variation of the mean and median inclinations in the numbered minor planet sample

    Energy Technology Data Exchange (ETDEWEB)

    Knezevic, Z. (Astronomical Observatory, Belgrade, Yugoslavia)

    1982-01-01

    Variations of the mean and median minor planet inclinations with the increase of the numbered minor planet sample size are investigated. An analysis is presented of the role of real features of the minor planet system and of the selectional effects connected with discoveries and inclusion in the list of numbered objects. Available data are discussed and prediction of the future behaviour of variations attempted.

  10. Effect of the inclination of support in cervical and upper limb development

    Directory of Open Access Journals (Sweden)

    Ailime Perito Feiber Heck

    Full Text Available Introduction It is expected that a child will acquire control of posture (CP of the head and upper limbs in a gradual, sequential and organized way. However, there is still no consensus regarding the best position to achieve this; the evidence suggests that it is prone. Objective To investigate whether age and inclination of the supporting surface in the prone position influence the alignment of the head and upper limbs of children with typical motor development (TMD and atypical motor development (AMD. Methods The study included 29 children aged between one and three months divided according to the Alberta Infant Motor Scale (AIMS into groups with TMD (n = 18 and AMD (n = 11. The children were placed in the prone position with three angles of the support surface (0°, 25° and 45°. Kinematic analysis was conducted to evaluate the alignment angles of the head and upper limbs. Results Children with TMD had higher head alignment. There was no difference in the upper limbs’ alignment between the group with TMD and the group with AMD. In the third month of age compared with the first, increased head alignment and decreased upper limb alignment were found in both groups. The inclination of the supporting surface did not influence the alignment of the head and upper limbs. Conclusions Among the positions evaluated, the prone position without inclination of the supporting surface was more appropriate for weight discharge in the upper limbs, favoring the development of postural control of the child.

  11. Heat removal capability of core-catcher with inclined cooling channels

    International Nuclear Information System (INIS)

    Suzuki, Y.; Tahara, M.; Kurita, T.; Hamazaki, R.; Morooka, S.

    2009-01-01

    A core-catcher is one of the mitigation systems that provide functions of molten corium cooling and stabilization during a severe accident. Toshiba has been developing a compact core-catcher to be placed at the lower drywell floor in the containment vessel for the next generation BWR as well as near term ABWR. This paper presents the evaluation of heat removal capability of the core-catcher with inclined cooling channels, our verification status and plan. The heat removal capability of the core-catcher is analyzed by using the newly developed two-phase flow analysis code which incorporates drift flux parameters for inclined channels and the CHF correlation obtained from SULTAN tests. Effects of geometrical parameters such as the inclination and the gap size of the cooling channel on the heat removal capability are also evaluated. These results show that the core-catcher has sufficient capability to cool the molten corium during a severe accident. Based on the analysis, it has been shown that the core-catcher has an efficient capability of heat removal to cool the molten corium. (author)

  12. Students’ understanding of forces: Force diagrams on horizontal and inclined plane

    Science.gov (United States)

    Sirait, J.; Hamdani; Mursyid, S.

    2018-03-01

    This study aims to analyse students’ difficulties in understanding force diagrams on horizontal surfaces and inclined planes. Physics education students (pre-service physics teachers) of Tanjungpura University, who had completed a Basic Physics course, took a Force concept test which has six questions covering three concepts: an object at rest, an object moving at constant speed, and an object moving at constant acceleration both on a horizontal surface and on an inclined plane. The test is in a multiple-choice format. It examines the ability of students to select appropriate force diagrams depending on the context. The results show that 44% of students have difficulties in solving the test (these students only could solve one or two items out of six items). About 50% of students faced difficulties finding the correct diagram of an object when it has constant speed and acceleration in both contexts. In general, students could only correctly identify 48% of the force diagrams on the test. The most difficult task for the students in terms was identifying the force diagram representing forces exerted on an object on in an inclined plane.

  13. Linear and Nonlinear Gait Features in Older Adults Walking on Inclined Surfaces at Different Speeds.

    Science.gov (United States)

    Vieira, Marcus Fraga; Rodrigues, Fábio Barbosa; de Sá E Souza, Gustavo Souto; Magnani, Rina Márcia; Lehnen, Georgia Cristina; Andrade, Adriano O

    2017-06-01

    This study evaluated linear and nonlinear gait features in healthy older adults walking on inclined surfaces at different speeds. Thirty-seven active older adults (experimental group) and fifty young adults (control group) walked on a treadmill at 100% and ±20% of their preferred walking speed for 4 min under horizontal (0%), upward (UP) (+8%), and downward (DOWN) (-8%) conditions. Linear gait variability was assessed using the average standard deviation of trunk acceleration between strides (VAR). Gait stability was assessed using the margin of stability (MoS). Nonlinear gait features were assessed by using the maximum Lyapunov exponent, as a measure of local dynamic stability (LDS), and sample entropy (SEn), as a measure of regularity. VAR increased for all conditions, but the interaction effects between treadmill inclination and age, and speed and age were higher for young adults. DOWN conditions showed the lowest stability in the medial-lateral MoS, but not in LDS. LDS was smaller in UP conditions. However, there were no effects of age for either MoS or LDS. The values of SEn decreased almost linearly from the DOWN to the UP conditions, with significant interaction effects of age for anterior-posterior SEn. The overall results supported the hypothesis that inclined surfaces modulate nonlinear gait features and alter linear gait variability, particularly in UP conditions, but there were no significant effects of age for active older adults.

  14. Attachment systems for implant overdenture: influence of implant inclination on retentive and lateral forces.

    Science.gov (United States)

    Yang, Tsung-Chieh; Maeda, Yoshinobu; Gonda, Tomoya; Kotecha, Sunny

    2011-11-01

    To evaluate the retentive force and lateral force of an implant with various types of attachments for overdentures in relation to implant inclination. An implant (3.75 × 13 mm) was embedded into an acrylic resin block, simulating the edentulous ridge. Four different attachment systems were used, including: (1) Locator black and blue, (2) a ball attachment, (3) a flat-type magnetic attachment and (4) a self-adjusting magnetic attachment, which has vertical and rotational movement. All of the attachments were under a constant dislodging force with an angle of the implant at 0°, 15°, 30° and 45°, and the experiments were repeated 10 times using a universal testing machine to measure the retentive force. The lateral force to the implant was measured by strain gauges attached on the implant surface. Statistical analysis was performed by multiple comparisons with Bonferroni's correction. Pattachments. The Locator blue and ball attachment maintained the retentive force until a 30° inclination; however, the lateral force increased significantly, especially with the ball attachment. The retentive force of the magnetic attachment was significantly lower at 0°, as well as the lateral force in the self-adjusting magnetic attachment. Within the limitations of this study, we conclude that the retentive force decreases with an increase in implant inclination, whereas the lateral force increases, except for in magnetic attachments. © 2011 John Wiley & Sons A/S.

  15. Modelling and Simulation of Free Floating Pig for Different Pipeline Inclination Angles

    Directory of Open Access Journals (Sweden)

    Woldemichael Dereje Engida

    2016-01-01

    Full Text Available This paper presents a modelling and simulation of free floating pig to determine the flow parameters to avoid pig stalling in pigging operation. A free floating spherical shaped pig was design and equipped with necessary sensors to detect leak along the pipeline. The free floating pig does not have internal or external power supply to navigate through the pipeline. Instead, it is being driven by the flowing medium. In order to avoid stalling of the pig, it is essential to conduct simulation to determine the necessary flow parameters for different inclination angles. Accordingly, a pipeline section with inclination of 0°, 15°, 30°, 45°, 60°, 75°, and 90° were modelled and simulated using ANSYS FLUENT 15.0 with water and oil as working medium. For each case, the minimum velocity required to propel the free floating pig through the inclination were determined. In addition, the trajectory of the free floating pig has been visualized in the simulation.

  16. Three-dimensional unsteady natural convection and entropy generation in an inclined cubical trapezoidal cavity with

    Directory of Open Access Journals (Sweden)

    Ahmed Kadhim Hussein

    2016-06-01

    Full Text Available Numerical computation of unsteady laminar three-dimensional natural convection and entropy generation in an inclined cubical trapezoidal air-filled cavity is performed for the first time in this work. The vertical right and left sidewalls of the cavity are maintained at constant cold temperatures. The lower wall is subjected to a constant hot temperature, while the upper one is considered insulated. Computations are performed for Rayleigh numbers varied as 103 ⩽ Ra ⩽ 105, while the trapezoidal cavity inclination angle is varied as 0° ⩽ Φ ⩽ 180°. Prandtl number is considered constant at Pr = 0.71. Second law of thermodynamics is applied to obtain thermodynamic losses inside the cavity due to both heat transfer and fluid friction irreversibilities. The variation of local and average Nusselt numbers is presented and discussed, while, streamlines, isotherms and entropy contours are presented in both two and three-dimensional pattern. The results show that when the Rayleigh number increases, the flow patterns are changed especially in three-dimensional results and the flow circulation increases. Also, the inclination angle effect on the total entropy generation becomes insignificant when the Rayleigh number is low. Moreover, when the Rayleigh number increases the average Nusselt number increases.

  17. Valuation of coefficient of rolling friction by the inclined plane method

    Science.gov (United States)

    Ciornei, F. C.; Alaci, S.; Ciogole, V. I.; Ciornei, M. C.

    2017-05-01

    A major objective of tribological researches is characterisation of rolling friction, due to various cases encountered in classical engineering applications, like gear transmissions and cam mechanisms or more recent examples met in bioengineering and biomedical devices. A characteristic of these examples consists in reduced dimensions of the contact zones, theoretically zero, the relative motion occurring between the contact points being either sliding or rolling. A characteristic parameter for the rolling motion is the coefficient of rolling friction. The paper proposes a method for estimation of coefficient of rolling friction by studying the motion of a body of revolution on an inclined plane. Assuming the hypothesis that moment of rolling friction is proportional to the normal reaction force, the law of motion for the body on the inclined plane is found under the premise of pure rolling. It is reached the conclusion that there is an uniformly accelerated motion, and thus for a known plane slope, it is sufficient to find the time during which the body runs a certain distance, starting from motionless situation. To obtain accurate results assumes finding precisely the time of motion. The coefficient of rolling friction was estimated for several slopes of the inclined plane and it is concluded that with increased slope, the values of coefficient of rolling friction increase, fact that suggest that the proportionality between the rolling torque and normal load is valid only for domains of limited variations of normal load.

  18. Heat transfer coefficient in pool boiling for an electrically heated tube at various inclinations

    International Nuclear Information System (INIS)

    Fahmy, A.S.A.; Mariy, A.H.; Mahmoud, S.I.; Ibrahim, N.A.

    1987-01-01

    An experimental investigation is carried out study the behaviour of heat transfer in pool boiling from a vertical and inclined heated tube at atmospheric pressure. An imperial correlation joining the different parameters affecting the heat transfer coefficient in pool boiling for an electrically heated tube at various inclinations is developed. Two test sections (zircaloy-4 and stainless steel) of 16 n n outer diameter and 120 nm length are investigated. Four levels of heat flux are used for heating the two lest sections (e.g. 381, 518, 721 and 929 k.watt/n 2). The maximum surface temperature achieved is 146.5 degree c for both materials, and the maximum bulk temperature is 95 degree C. It is found that the average heat transfer coefficient is inversely proportional with heated length l, where it reaches a constant value in the horizontal position. The heat transfer coefficient curves at various inclinations with respect to the heated tube length pass around one point which is defined as limit length

  19. Why People with More Emotion Regulation Difficulties Made a More Deontological Judgment: The Role of Deontological Inclinations.

    Science.gov (United States)

    Zhang, Lisong; Li, Zhongquan; Wu, Xiaoyuan; Zhang, Ziyuan

    2017-01-01

    Previous studies have demonstrated the key role of emotion in moral judgment, and explored the relationship between emotion regulation and moral judgment. The present study investigated the influence of individual differences in emotion regulation difficulties on moral judgment. Study 1 examined whether individuals with high emotion regulation difficulties made a more deontological judgment. Study 2 explored the underlying mechanism using a process-dissociation approach, examining whether deontological inclinations and utilitarian inclinations separately or jointly accounted for the association. The results indicated that individuals with high emotion regulation difficulties rated the utilitarian actions less morally appropriate, and one's deontological inclinations mediated the association between emotion regulation difficulties and moral judgment.

  20. Combined free and forced laminar convection in inclined rectangular channels heated from below and cooled from above

    International Nuclear Information System (INIS)

    Akinsete, V.A.; Bello-Ochende, F.L.

    1981-01-01

    Steady-state numerical results for the solution to the non-linear thermal problem of combined free and forced laminar convection in inclined rectangular channels with constant but unequal surface temperature are presented for an incompressible, viscous fluid whose Prandtl number, Pr = 0.73. Fluid properties are assumed constant, except for density variations with temperature. Maximum values exist for the mean friction factor, Nusselt and Stanton numbers when the inclination to the horizontal lies between 30 0 and 60 0 for a given Archimedes number, Ar. Also, for any given inclination a unique solution exists when Ar = 0,50. (Author) [pt

  1. Influence of the nucleation surface inclination on heat transfers and on the growth dynamics of a steam bubble

    International Nuclear Information System (INIS)

    Barthes, M.; Reynard, Ch.; Santini, R.; Tadrist, L.

    2006-01-01

    The influence of the inclination of the nucleation surface on heat and mass transfers and on the growth dynamics of a single steam bubble is experimentally studied. The bubble is created beneath a wall with an imposed heating flux. The evolution of geometrical bubble parameters and of the frequency of emission with respect to the inclination angle are presented. The total heat flux measurements are compared to the evaporation fluxes determined by image processing. Contrary to the evaporation flux, the total flux is conditioned by the inclination and thus is correlated to the frequency of bubbles emission. (J.S.)

  2. A study of the rates of heat transfer and bubble site density for nucleate boiling on an inclined heating surface

    International Nuclear Information System (INIS)

    Bonamy, S.E.; Symons, J.G.

    1974-08-01

    Nucleate pool boiling of distilled water from an electrically heated surface at atmospheric pressure is studied for varying heating surface inclinations. The constants of the accepted boiling equation phi = K Tsup(B) and the Rohsenow Correlation Coefficient are found to be dependent on surface orientation. Convection cooling is observed to play a major role in pool boiling phenomena and causes large changes in the heat transfer rates for a given excess of temperature of the heated surface. Active nucleation site density is studied and found to be independent of surface inclination. Empirical relations are presented to provide an understanding of the effects of inclination on other boiling parameters. (author)

  3. Measurement of defects on the wall by use of the inclination angle of laser slit beam and position tracking algorithm of camera

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Young Hwan; Yoon, Ji Sup; Jung, Jae Hoo; Hong, Dong Hee; Park, Gee Yong

    2001-01-01

    In this paper, a method of measuring the size of defects on the wall and restructuring the defect image is proposed based on the estimation algorithm of a camera orientation which uses the declination angle of the line slit beam. To reconstruct the image, an algorithm of estimating the horizontally inclined angle of CCD camera is presented. This algorithm adopts a 3-dimensional coordinate transformation of the image plane where both the LASER beam and the original image of the defects exist. The estimation equation is obtained by using the information of the beam projected on the wall and the parameters of this equation are experimentally obtained. With this algorithm, the original image of the defect can be reconstructed into the image which is obtained by a camera normal to the wall. From the result of a series of experiment shows that the measuring accuracy of the defect is within 0.5% error bound of real defect size under 30 degree of the horizontally inclined angle. Also, the accuracy is deteriorates with the error rate of 1% for every 10 degree increase of the horizontally inclined angle. The estimation error increases in the range of 30{approx}50 degree due to the existence of dead zone of defect depth, and defect length can not be measured due to the disappearance of image data above 70 degree. In case of under water condition, the measuring accuracy is also influenced due to the changed field of view of both the camera and the laser slit beam caused by the refraction rate in the water. The proposed algorithm provides the method of reconstructing the image taken at any arbitrary camera orientation into the image which is obtained by a camera normal to the wall and thus it enables the accurate measurement of the defect lengths only by using a single camera and a laser slit beam.

  4. A dose-ranging study of 0.5% bupivacaine or ropivacaine on the success and duration of the ultrasound-guided, nerve-stimulator-assisted sciatic nerve block: a double-blind, randomized clinical trial.

    Science.gov (United States)

    Nader, Antoun; Kendall, Mark C; De Oliveira, Gildasio S; Puri, Lalit; Tureanu, Luminita; Brodskaia, Alina; Asher, Yogen; Parimi, Vamsi; McCarthy, Robert J

    2013-01-01

    Before bifurcation, the sciatic nerve is composed of 2 component nerves encased in a common investing extraneural layer (CIEL). We examined the effect of various volumes injected beneath the CIEL on the success and duration of sciatic nerve block. Ultrasound-guided nerve-stimulator-assisted sciatic nerve blocks were performed on 142 subjects. Subjects were randomized into 14 groups (0.5% ropivacaine or bupivacaine) with epinephrine 1:300,000 in volumes ranging from 2.5 to 30 mL. Successful block was defined as a complete sensory and motor block at 60 minutes. The minimum threshold current, time to complete block, duration of sensory and motor block, postoperative pain, and analgesic requirements were recorded. The mean threshold current external to the CIEL was 0.52 (0.15) mA compared to 0.19 (0.09) mA beneath the CIEL (P block was achieved in 30 of 40 subjects that received 5 mL or less of ropivacaine or bupivacaine compared with 97 of 99 that received 10 mL or greater volume (P = 0.006). Injection volumes greater than or equal to 10 mL produced complete sensory and motor block within 30 minutes. Volumes greater than 10 mL did not extend the duration of the sensory or motor block. Injection volumes of 2.5 and 5 mL were associated with delayed onset and decreased block duration and a greater fraction of subjects experiencing pain behind the knee. Injecting 10 mL of 0.5% bupivacaine or ropivacaine below the CIEL produces comparable onset and duration of sensory and motor blockade as volumes as large as 30 mL.

  5. Comparison of the activity of the gluteus medius according to the angles of inclination of a treadmill with vertical load.

    Science.gov (United States)

    Jeong, Da-Eun; Lee, Su-Kyoung; Kim, Kyoung

    2014-02-01

    [Purpose] The purpose of this study was to compare the muscle activity of the gluteus medius according to treadmill inclination during gait with a vertical load on a treadmill. [Methods] Sixteen healthy subjects were recruited for this study. The subjects walked on a treadmill at inclination angles of 0, 5, and 10 degrees. [Results] Muscle activity of the gluteus medius increased at 5° compared to 0° treadmill inclination, though the difference was not significant. On the other hand, gluteus medius muscle activity significantly decreased in treadmill walking at an inclination of 10° compared to 5°. [Conclusion] Selective strengthening exercises using a 5° treadmill angle could be useful for patients experiencing gluteus medius weakness.

  6. Visualization of the impact of water drops on a hot surface: effect of drop velocity and surface inclination

    Energy Technology Data Exchange (ETDEWEB)

    Celata, Gian Piero; Mariani, Andrea; Zummo, Giuseppe [ENEA, Institute of Thermal-Fluid Dynamics, S. Maria di Galeria (Rome) (Italy); Cumo, Maurizio [Universita di Roma ' ' La Sapienza' ' , Rome (Italy)

    2006-08-15

    The behaviour of one drop impinging on a hot surface by varying the surface temperature, the drop velocity and the position of the surface (horizontal and a inclined 45 ) both at a temperature below and above the Leidenfrost temperature has been experimentally evaluated, estimating the temperature at which the drop rebounds. A large influence on the drop velocity has been evidenced. The inclination of the surface decreases the critical value of the temperature above which the surface is not rewetted. (orig.)

  7. The Effects of Boundary Conditions and Friction on the Helical Buckling of Coiled Tubing in an Inclined Wellbore.

    Science.gov (United States)

    Gong, Yinchun; Ai, Zhijiu; Sun, Xu; Fu, Biwei

    2016-01-01

    Analytical buckling models are important for down-hole operations to ensure the structural integrity of the drill string. A literature survey shows that most published analytical buckling models do not address the effects of inclination angle, boundary conditions or friction. The objective of this paper is to study the effects of boundary conditions, friction and angular inclination on the helical buckling of coiled tubing in an inclined wellbore. In this paper, a new theoretical model is established to describe the buckling behavior of coiled tubing. The buckling equations are derived by applying the principles of virtual work and minimum potential energy. The proper solution for the post-buckling configuration is determined based on geometric and natural boundary conditions. The effects of angular inclination and boundary conditions on the helical buckling of coiled tubing are considered. Many significant conclusions are obtained from this study. When the dimensionless length of the coiled tubing is greater than 40, the effects of the boundary conditions can be ignored. The critical load required for helical buckling increases as the angle of inclination and the friction coefficient increase. The post-buckling behavior of coiled tubing in different configurations and for different axial loads is determined using the proposed analytical method. Practical examples are provided that illustrate the influence of the angular inclination on the axial force. The rate of change of the axial force decreases with increasing angular inclination. Moreover, the total axial friction also decreases with an increasing inclination angle. These results will help researchers to better understand helical buckling in coiled tubing. Using this knowledge, measures can be taken to prevent buckling in coiled tubing during down-hole operations.

  8. The Effects of Boundary Conditions and Friction on the Helical Buckling of Coiled Tubing in an Inclined Wellbore.

    Directory of Open Access Journals (Sweden)

    Yinchun Gong

    Full Text Available Analytical buckling models are important for down-hole operations to ensure the structural integrity of the drill string. A literature survey shows that most published analytical buckling models do not address the effects of inclination angle, boundary conditions or friction. The objective of this paper is to study the effects of boundary conditions, friction and angular inclination on the helical buckling of coiled tubing in an inclined wellbore. In this paper, a new theoretical model is established to describe the buckling behavior of coiled tubing. The buckling equations are derived by applying the principles of virtual work and minimum potential energy. The proper solution for the post-buckling configuration is determined based on geometric and natural boundary conditions. The effects of angular inclination and boundary conditions on the helical buckling of coiled tubing are considered. Many significant conclusions are obtained from this study. When the dimensionless length of the coiled tubing is greater than 40, the effects of the boundary conditions can be ignored. The critical load required for helical buckling increases as the angle of inclination and the friction coefficient increase. The post-buckling behavior of coiled tubing in different configurations and for different axial loads is determined using the proposed analytical method. Practical examples are provided that illustrate the influence of the angular inclination on the axial force. The rate of change of the axial force decreases with increasing angular inclination. Moreover, the total axial friction also decreases with an increasing inclination angle. These results will help researchers to better understand helical buckling in coiled tubing. Using this knowledge, measures can be taken to prevent buckling in coiled tubing during down-hole operations.

  9. Correlation between cuspal inclination and tooth cracked syndrome: a three-dimensional reconstruction measurement and finite element analysis.

    Science.gov (United States)

    Qian, Yunzhu; Zhou, Xuefeng; Yang, Jianxin

    2013-06-01

    This paper explored the correlation between cuspal inclination and tooth cracked syndrome by measuring and reconstructing the cuspal inclinations of cracked maxillary first molars through three-dimensional (3D) finite element analysis (FEA). The cuspal inclinations of 11 maxillary left first molars with cracked tooth syndrome and 22 intact controls were measured by 3D reconstruction. The mean values of each group were used to construct two 3D finite element models of maxillary first molar for comparing stress distribution under the loads of 200N at 0°, 45°, and 90°, respectively, to the tooth axis. There was statistically significant difference in the cuspal inclination between the incompletely fractured group and the intact control group ( P  < 0.001), which was 5.5-6.7 degrees steeper. The model from the mean cuspal inclinations of the incompletely fractured molars showed the maximum tensile stress of 5.83, 10.87, and 25.32 MPa, respectively, in comparison with 5.40, 8.49, and 22.76 MPa for the model of the control group. Besides, the tensile stress was mainly at the center groove and cervical region of the molar model. Steeper cuspal inclinations resulted in an increment in tensile stress that was mainly at the center groove and cervical region of the molar model under equivalent loads. Higher unfavorable tensile stress was generated with the increasing horizontal component load on the cuspal incline. This indicates an effective reduction of cuspal inclination to the compromised teeth for dentists. © 2012 John Wiley & Sons A/S.

  10. ANISOTROPY-BASED INCLINATION CORRECTION FOR THE MOENAVE FORMATION AND WINGATE SANDSTONE: IMPLICATIONS FOR COLORADO PLATEAU ROTATION

    Directory of Open Access Journals (Sweden)

    Andrea eMcCall

    2014-07-01

    Full Text Available The ~ 201 Ma paleopole for North America at the Triassic-Jurassic boundary is observed in two widely different locations; one paleopole is determined from the Mesozoic rift basins in eastern North America and the other from the Colorado Plateau in the southwestern United States. A large discrepancy in paleopole positions from these two localities has been attributed to large amounts of clockwise vertical axis rotation of the Colorado Plateau (>10º combined with inclination shallowing of the paleomagnetism. The sedimentary inclinations of the eastern North American basins have been corrected for shallowing, but the Colorado Plateau inclinations have not. Simple vertical axis rotation of the Colorado Plateau is not enough to bring the two paleopoles into agreement. This study of the Moenave and Wingate Formations was conducted to correct Colorado Plateau inclinations using their high field isothermal remanent anisotropy. The Moenave Formation and laterally equivalent Wingate Sandstone, which span the Triassic-Jurassic boundary, were sampled in southern Utah and northern Arizona. Thermal demagnetization isolated a characteristic remanence carried by hematite from 20 sites. High field (5 T isothermal remanent anisotropy indicated shallowing of the characteristic remanence with an average flattening factor of f=0.69. An inclination-corrected paleopole for the Moenave and Wingate Formations is located at 62.5˚N 69.9˚E (α95=5.5˚ and is shifted northward by 2.9˚ with respect to the uncorrected paleopole. When the inclination corrected paleopole is rotated counterclockwise 9.7º about an Euler pole local to the Colorado Plateau, it is statistically indistinguishable from the inclination-corrected paleopole from the eastern North American rift basins. Rotation of the uncorrected paleopole does not bring it into statistical agreement with rift basin paleopole, therefore an inclination shallowing correction is necessary to support rotation of the

  11. The Inclination of the Soft X-Ray Transient A0620-00 and the Mass of its Black Hole

    Science.gov (United States)

    Cantrell, Andrew G.; Bailyn, Charles D.; Orosz, Jerome A.; McClintock, Jeffrey E.; Remillard, Ronald A.; Froning, Cynthia S.; Neilsen, Joseph; Gelino, Dawn M.; Gou, Lijun

    2010-02-01

    We analyze photometry of the soft X-ray transient A0620 - 00 spanning nearly 30 years, including previously published and previously unpublished data. Previous attempts to determine the inclination of A0620 using subsets of these data have yielded a wide range of measured values of i. Differences in the measured value of i have been due to changes in the shape of the light curve and uncertainty regarding the contamination from the disk. We give a new technique for estimating the disk fraction and find that disk light is significant in all light curves, even in the infrared. We also find that all changes in the shape and normalization of the light curve originate in a variable disk component. After accounting for this disk component, we find that all the data, including light curves of significantly different shapes, point to a consistent value of i. Combining results from many separate data sets, we find i = 51fdg0 ± 0fdg9, implying M = 6.6 ± 0.25 M sun. Using our dynamical model and zero-disk stellar VIH magnitudes, we find d = 1.06 ± 0.12 kpc. Understanding the disk origin of nonellipsoidal variability may assist with making reliable determinations of i in other systems, and the fluctuations in disk light may provide a new observational tool for understanding the three-dimensional structure of the accretion disk.

  12. THE INCLINATION OF THE SOFT X-RAY TRANSIENT A0620-00 AND THE MASS OF ITS BLACK HOLE

    International Nuclear Information System (INIS)

    Cantrell, Andrew G.; Bailyn, Charles D.; Orosz, Jerome A.; McClintock, Jeffrey E.; Gou, Lijun; Remillard, Ronald A.; Froning, Cynthia S.; Neilsen, Joseph; Gelino, Dawn M.

    2010-01-01

    We analyze photometry of the soft X-ray transient A0620 - 00 spanning nearly 30 years, including previously published and previously unpublished data. Previous attempts to determine the inclination of A0620 using subsets of these data have yielded a wide range of measured values of i. Differences in the measured value of i have been due to changes in the shape of the light curve and uncertainty regarding the contamination from the disk. We give a new technique for estimating the disk fraction and find that disk light is significant in all light curves, even in the infrared. We also find that all changes in the shape and normalization of the light curve originate in a variable disk component. After accounting for this disk component, we find that all the data, including light curves of significantly different shapes, point to a consistent value of i. Combining results from many separate data sets, we find i = 51. 0 0 ± 0. 0 9, implying M = 6.6 ± 0.25 M sun . Using our dynamical model and zero-disk stellar VIH magnitudes, we find d = 1.06 ± 0.12 kpc. Understanding the disk origin of nonellipsoidal variability may assist with making reliable determinations of i in other systems, and the fluctuations in disk light may provide a new observational tool for understanding the three-dimensional structure of the accretion disk.

  13. Rolling stones: The motion of a sphere down an inclined plane coated with a thin liquid film

    Science.gov (United States)

    Bico, J.; Ashmore-Chakrabarty, J.; McKinley, G. H.; Stone, H. A.

    2009-08-01

    A spherical bead deposited on a smooth tilted dry plane wall rolls down the slope under the uniform acceleration of gravity. We describe an analogous experiment conducted using a plane wall that is coated with a thin layer (of order 50-100 μm) of a viscous liquid. The steady motion of the sphere under gravity involves a combination of rotation and sliding. We examine the dependence of the experimentally observed steady translational and rotational speeds on the physical parameters in the system. In particular, the interplay between viscous forces and interfacial forces leads to nontrivial exponents for the scaling of the speeds with the characteristics of the sphere and the viscous liquid. The overhang situation, in which the sphere rolls down the underside of an inclined lubricated plane, is also examined. In this case, the steady motion is still observed for a certain range of angles and bead sizes; that is, the sphere does not always detach from the surface. The adhesive force arises dynamically from the motion of the sphere and can exceed classical quasistatic capillary forces. Such a force should also play a role in other problems of lubrication mechanics such as humid granular flows.

  14. Studi Numerik Pengaruh Baffle Inclination Pada Alat Penukar Kalor Tipe U – Tube Terhadap Aliran Fluida Dan Perpindahan Panas

    Directory of Open Access Journals (Sweden)

    Reza Hidayatullah

    2014-09-01

    Full Text Available Alat penukar kalor sangat berpengaruh dalam industri terhadap keberhasilan keseluruhan rangkaian proses, karena kegagalan operasi alat ini baik akibat kegagalan mekanikal maupun opersional dapat menyebabkan berhentinya operasi unit. Penelitian terhadap desain heat exchanger masih terus dilakukan untuk mencari kinerja dari heat exchanger yang paling optimal, baik pada bagian baffle cut dan baffles inclination maupun susunan dari tube dengan menggunakan heat exchanger ukuran kecil sebagai model. Berdasarkan pada permasalahan di atas, maka dilakukan penelitian terhadap kinerja heat exchanger tipe U-tube dengan memvariasikan baffle inclination. Penelitian ini dilakukan secara numerik dengan variasi baffle inclination sebesar 0o, 10o, 20o dan variasi laju aliran massa sebesar 0,5 kg/s, 1kg/s, dan 2 kg/s. Tube yang digunakan adalah tipe U-tube yang disusun secara persegi. Model viskous yang digunakan adalah turbulensi model yaitu k-ε standar, dimana fluida yang digunakan adalah air pada boundary condition. Hasil analisa numerik menunjukkan adanya pengaruh baffle inclination pada alat penukar kalor tipe U – tube terhadap aliran fluida dan perpindahan panas. Peningkatan laju aliran massa dapat meningkatkan pressure drop secara cepat, alat penukar kalor shell and tube tipe U – tube dengan baffle inclination 20o memiliki unjuk kerja yang terbaik dibandingkan dengan baffle inclination 0o dan 10o.

  15. Influence of angle of inclination on power of solar module; Taiyo denchi module no keisha kakudo to shutsuryoku tokusei

    Energy Technology Data Exchange (ETDEWEB)

    Tsutsumi, K.; Nishitani, M. [Dai Ichi University, College of Technology, Kagoshima (Japan)

    1997-11-25

    Experiment/study were conducted on the influence of angle of inclination on output of solar modules. In the experiment, changing the angle of inclination of the photovoltaic module installed on the top of school building to 0, 30, 60 and 90 degC, the global radiation on an inclined surface was measured by pyranometer equipped with the module, and at the same time output characteristics were measured by I-V curve tracer. In the I-V curve tracer, voltage, current, and output capability diagram are illustrated automatically changing bias voltage to get the maximum output. The global radiation on an inclined surface and the maximum output indicated an almost proportional relation and were expressed in a recursion method. Moreover, measurement of the global radiation is usually conducted using the amount of global radiation on a horizontal surface, and the global radiation on an inclined surface is calculated as a sum of the direct solar radiation amount and the sky solar radiation amount after determining a penetration rate by the relational equation. By calculating the global radiation on an inclined surface, it becomes possible to calculate the maximum output of photovoltaic modules by this recursion method. 1 ref., 6 figs., 1 tab.

  16. Computational parametric study of a Richtmyer-Meshkov instability for an inclined interface.

    Science.gov (United States)

    McFarland, Jacob A; Greenough, Jeffrey A; Ranjan, Devesh

    2011-08-01

    A computational study of the Richtmyer-Meshkov instability for an inclined interface is presented. The study covers experiments to be performed in the Texas A&M University inclined shock tube facility. Incident shock wave Mach numbers from 1.2 to 2.5, inclination angles from 30° to 60°, and gas pair Atwood numbers of ∼0.67 and ∼0.95 are used in this parametric study containing 15 unique combinations of these parameters. Qualitative results are examined through a time series of density plots for multiple combinations of these parameters, and the qualitative effects of each of the parameters are discussed. Pressure, density, and vorticity fields are presented in animations available online to supplement the discussion of the qualitative results. These density plots show the evolution of two main regions in the flow field: a mixing region containing driver and test gas that is dominated by large vortical structures, and a more homogeneous region of unmixed fluid which can separate away from the mixing region in some cases. The interface mixing width is determined for various combinations of the parameters listed at the beginning of the Abstract. A scaling method for the mixing width is proposed using the interface geometry and wave velocities calculated using one-dimensional gas dynamic equations. This model uses the transmitted wave velocity for the characteristic velocity and an initial offset time based on the travel time of strong reflected waves. It is compared to an adapted Richtmyer impulsive model scaling and shown to scale the initial mixing width growth rate more effectively for fixed Atwood number.

  17. Quasi-Rayleigh waves in transversely isotropic half-space with inclined axis of symmetry

    International Nuclear Information System (INIS)

    Yanovskaya, T.B.; Savina, L.S.

    2003-09-01

    A method for determination of characteristics of quasi-Rayleigh (qR) wave in a transversely isotropic homogeneous half-space with inclined axis of symmetry is outlined. The solution is obtained as a superposition of qP, qSV and qSH waves, and surface wave velocity is determined from the boundary conditions at the free surface and at infinity, as in the case of Rayleigh wave in isotropic half-space. Though the theory is simple enough, a numerical procedure for the calculation of surface wave velocity presents some difficulties. The difficulty is conditioned by necessity to calculate complex roots of a non-linear equation, which in turn contains functions determined as roots of nonlinear equations with complex coefficients. Numerical analysis shows that roots of the equation corresponding to the boundary conditions do not exist in the whole domain of azimuths and inclinations of the symmetry axis. The domain of existence of qR wave depends on the ratio of the elastic parameters: for some strongly anisotropic models the wave cannot exist at all. For some angles of inclination qR wave velocities deviate from those calculated on the basis of the perturbation method valid for weak anisotropy, though they have the same tendency of variation with azimuth. The phase of qR wave varies with depth unlike Rayleigh wave in isotropic half-space. Unlike Rayleigh wave in isotropic half-space, qR wave has three components - vertical, radial and transverse. Particle motion in horizontal plane is elliptic. Direction of the major axis of the ellipsis coincide with the direction of propagation only in azimuths 0 deg. (180 deg.) and 90 deg. (270 deg.). (author)

  18. MHD natural convection in open inclined square cavity with a heated circular cylinder

    Science.gov (United States)

    Hosain, Sheikh Anwar; Alim, M. A.; Saha, Satrajit Kumar

    2017-06-01

    MHD natural convection in open cavity becomes very important in many scientific and engineering problems, because of it's application in the design of electronic devices, solar thermal receivers, uncovered flat plate solar collectors having rows of vertical strips, geothermal reservoirs, etc. Several experiments and numerical investigations have been presented for describing the phenomenon of natural convection in open cavity for two decades. MHD natural convection and fluid flow in a two-dimensional open inclined square cavity with a heated circular cylinder was considered. The opposite wall to the opening side of the cavity was first kept to constant heat flux q, at the same time the surrounding fluid interacting with the aperture was maintained to an ambient temperature T∞. The top and bottom wall was kept to low and high temperature respectively. The fluid with different Prandtl numbers. The properties of the fluid are assumed to be constant. As a result a buoyancy force is created inside the cavity due to temperature difference and natural convection is formed inside the cavity. The Computational Fluid Dynamics (CFD) code are used to discretize the solution domain and represent the numerical result to graphical form.. Triangular meshes are used to obtain the solution of the problem. The streamlines and isotherms are produced, heat transfer parameter Nu are obtained. The results are presented in graphical as well as tabular form. The results show that heat flux decreases for increasing inclination of the cavity and the heat flux is a increasing function of Prandtl number Pr and decreasing function of Hartmann number Ha. It is observed that fluid moves counterclockwise around the cylinder in the cavity. Various recirculations are formed around the cylinder. The almost all isotherm lines are concentrated at the right lower corner of the cavity. The object of this work is to develop a Mathematical model regarding the effect of MHD natural convection flow around

  19. Iron-mineral-based magnetoreceptor in birds: polarity or inclination compass?

    DEFF Research Database (Denmark)

    Solov'yov, Ilia; Greiner, Walter

    2009-01-01

    In the present paper we demonstrate that the iron-mineral-based magnetoreceptor model can provide birds with a magnetic compass in addition to the generally believed "magnetic map". We show that the iron-mineral-based magnetoreceptor system possesses all properties of a polarity compass, which...... is extremely important for avian navigation. We study how parameters of the magnetoreceptor system influence on the properties of the compass and show that at certain conditions it acquires features of an inclination compass. In the present paper we address the question of avian magnetoreception theoretically...

  20. Exponentially varying viscosity of magnetohydrodynamic mixed convection Eyring-Powell nanofluid flow over an inclined surface

    Science.gov (United States)

    Khan, Imad; Fatima, Sumreen; Malik, M. Y.; Salahuddin, T.

    2018-03-01

    This paper explores the theoretical study of the steady incompressible two dimensional MHD boundary layer flow of Eyring-Powell nanofluid over an inclined surface. The fluid is considered to be electrically conducting and the viscosity of the fluid is assumed to be varying exponentially. The governing partial differential equations (PDE's) are reduced into ordinary differential equations (ODE's) by applying similarity approach. The resulting ordinary differential equations are solved successfully by using Homotopy analysis method. The impact of pertinent parameters on velocity, concentration and temperature profiles are examined through graphs and tables. Also coefficient of skin friction, Sherwood and Nusselt numbers are illustrated in tabular and graphical form.

  1. Testing corrections for paleomagnetic inclination error in sedimentary rocks: A comparative approach

    Science.gov (United States)

    Tauxe, Lisa; Kodama, Kenneth P.; Kent, Dennis V.

    2008-08-01

    Paleomagnetic inclinations in sedimentary formations are frequently suspected of being too shallow. Recognition and correction of shallow bias is therefore critical for paleogeographical reconstructions. This paper tests the reliability of the elongation/inclination ( E/ I) correction method in several ways. First we consider the E/ I trends predicted by various PSV models. We explored the role of sample size on the reliability of the E/ I estimates and found that for data sets smaller than ˜100-150, the results were less reliable. The Giant Gaussian Process-type paleosecular variation models were all constrained by paleomagnetic data from lava flows of the last five million years. Therefore, to test whether the method can be used in more ancient times, we compare model predictions of E/ I trends with observations from five Large Igneous Provinces since the early Cretaceous (Yemen, Kerguelen, Faroe Islands, Deccan and Paraná basalts). All data are consistent at the 95% level of confidence with the E/ I trends predicted by the paleosecular variation models. The Paraná data set also illustrated the effect of unrecognized tilting and combining data over a large latitudinal spread on the E/ I estimates underscoring the necessity of adhering to the two principle assumptions of the method. Then we discuss the geological implications of various applications of the E/ I method. In general the E/ I corrected data are more consistent with data from contemporaneous lavas, with predictions from the well constrained synthetic apparent polar wander paths, and other geological constraints. Finally, we compare the E/ I corrections with corrections from an entirely different method of inclination correction: the anisotropy of remanence method of Jackson et al. [Jackson, M.J., Banerjee, S.K., Marvin, J.A., Lu, R., Gruber, W., 1991. Detrital remanence, inclination errors and anhysteretic remanence anisotropy: quantitative model and experimental results. Geophys. J. Int. 104, 95

  2. Effect of a marginal inclination on pattern formation in a binary liquid mixture under thermal stress.

    Science.gov (United States)

    Croccolo, Fabrizio; Scheffold, Frank; Vailati, Alberto

    2013-07-05

    Convective motions in a fluid layer are affected by its orientation with respect to the gravitational field. We investigate the long-term stability of a thermally stressed layer of a binary liquid mixture and show that pattern formation is strongly affected by marginal inclinations as small as a few milliradians. At small Rayleigh numbers, the mass transfer is dominated by the induced large scale shear flow, while at larger Rayleigh numbers, it is dominated by solutal convection. At the transition, the balance between the solutal and shear flows gives rise to drifting columnar flows moving in opposite directions along parallel lanes in a superhighway configuration.

  3. On the unsteady flow of two visco-elastic fluids between two inclined porous plates

    Directory of Open Access Journals (Sweden)

    P. R. Sengupta

    1992-01-01

    Full Text Available This study is concerned with both hydrodynamic and hydromagnetic unsteady slow flows of two immiscible visco-elastic fluids of Rivlin-Ericksen type between two porous parallel nonconducting plates inclined at a certain angle to the horizontal. The exact solutions for the velocity fields, skin frictions, and the interface velocity distributions are found for both fluid models. Numerical results are presented in graphs. A comparison is made between the hydrodynamic and hydromagnetic velocity profiles. It is shown that the velocity is diminished due to the presence of a transverse magnetic field.

  4. Possible inclinations for psychostimulant, toxic agent and drug abuse among youths and students

    Directory of Open Access Journals (Sweden)

    V. G. Ginzburg

    2012-03-01

    Full Text Available Taking into account modern achievements in medicine, psychology and sociology, the attempt at complex research of possible inclinations for psychostimulant, toxic agent and drug abuse among youths and students was made with the subsequent determination of the possible alternates of primary prevention. It is analysed the basic and additional risk factors promoting smoking, drinking, psychostimulant abuse, toxicomania and narcomania among young people. The dynamics of possible influences of medical, psychological and social factors is studied. The attempt of short-term prognostication and ranking was made.

  5. Assessment of slip resistance under footwear materials, tread designs, floor contamination, and floor inclination conditions.

    Science.gov (United States)

    Li, Kai Way; Chen, Chih-Yong; Chen, Ching Chung; Liu, Liwen

    2012-01-01

    Slip and fall incidences are common in our daily lives. They are not only important environmental safety issues but also important occupational safety and health problems. The purpose of this study was to use the Brungraber Mark II to measure the friction so as to investigate the effects of the shoe sole, surface condition and the inclined angle of the floor and their interactions on friction coefficient. The results of the study showed the effects of all the main factors and their interactions were significant (p<0.001). Engineering designs & ergonomic interventions in slip & fall prevention should take these factors in full consideration.

  6. Pemakaian Inclined Bite Plane untuk Koreksi Gigitan Terbalik Interior pada Anak

    Directory of Open Access Journals (Sweden)

    Debrania Santoso

    2012-12-01

    Full Text Available Latar Belakang. Anak dengan gigitan terbalik pada anterior pada umumnya mempunyai keluhan dalam hal estetik dan fungsi pengunyahan. Kondisi gigitan terbalik biasanya disebabkan oleh adanya kebiasaan buruk dan faktor keturunan yang semakin memperparah keadaan tersebut. Pada kasus ini ditampilkan dua anak dengan gigitan terbalik anterior yang disebabkan oleh adanya kebiasaan buruk bertopang dagu dan mendorong lidah ke gigi anterior bawah. Perawatan menggunakan inclined bite plane dapat mengkoreksi gigitan terbalik anterior. Tujuan. Laporan kasus ini adalah untuk melaporkan bahwa pemakaian alat inlined bite plane dapat mengkoreksi gigitan terbalik anterior pada anak. Kasus. Dua orang anak perempuan dengan kasus gigitan terbalik anterior dilakukan pemeriksaan di poli gigi anak RSGM. Dari anamnesa diketahui bahwa anak pertama memiliki kebiasaan buruk bertopang dagu dan anak kedua mendorong lidah ke gigi anterior bawah. Perawatan yang dipilih adalah menggunakan alat inlined bite plane yang harus digunakan setiap hari saat tidur kecuali waktu makan dan menggosok gigi. Perawatan lanjutan pasien pertama tetap menggunakan alat removable dan pasien kedua dengan fixed orthodonti. Kesimpulan. Pasien pertama setelah 7 minggu gigitan terbalik anterior terkoreksi dan kebiasaan buruk dapat dihentikan. Pada pasien kedua gigitan terbalik anterior terkoreksi setelah 5 minggu. Hubungan oklusi pada pasien kedua lebih baik dibandingkan pasien pertama.   Background. Children with anterior crossbite generally complaint about aesthetic and masticatory function. Anterior crossbite is usually caused by bad habits and hereditary factors that exacerbated this situation. In this case was displayed two children with anterior crossbite caused by a bad habit pushing the chin with one hand and pushing the tongue to the lower anterior teeth. Treatment approach using inclined bite plane correct the anterior crossbite. Purpose. The purpose of this case report is to report the use

  7. Interfraction patient motion and implant displacement in prostate high dose rate brachytherapy

    International Nuclear Information System (INIS)

    Fox, C. D.; Kron, T.; Leahy, M.; Duchesne, G.; Williams, S.; Tai, K. H.; Haworth, A.; Herschtal, A.; Foroudi, F.

    2011-01-01

    Purpose: To quantify movement of prostate cancer patients undergoing treatment, using an in-house developed motion sensor in order to determine a relationship between patient movement and high dose rate (HDR) brachytherapy implant displacement. Methods: An electronic motion sensor was developed based on a three axis accelerometer. HDR brachytherapy treatment for prostate is delivered at this institution in two fractions 24 h apart and 22 patients were monitored for movement over the interval between fractions. The motion sensors functioned as inclinometers, monitoring inclination of both thighs, and the inclination and roll of the abdomen. The implanted HDR brachytherapy catheter set was assessed for displacement relative to fiducial markers in the prostate. Angle measurements and angle differences over a 2 s time base were binned, and the standard deviations of the resulting frequency distributions used as a metric for patient motion in each monitored axis. These parameters were correlated to measured catheter displacement using regression modeling. Results: The mean implant displacement was 12.6 mm in the caudal direction. A mean of 19.95 h data was recorded for the patient cohort. Patients generally moved through a limited range of angles with a mean of the exception of two patients who spent in excess of 2 h lying on their side. When tested for a relationship between movement in any of the four monitored axes and the implant displacement, none was significant. Conclusions: It is not likely that patient movement influences HDR prostate implant displacement. There may be benefits to patient comfort if nursing protocols were relaxed to allow patients greater freedom to move while the implant is in situ.

  8. Interfraction patient motion and implant displacement in prostate high dose rate brachytherapy

    Energy Technology Data Exchange (ETDEWEB)

    Fox, C. D.; Kron, T.; Leahy, M.; Duchesne, G.; Williams, S.; Tai, K. H.; Haworth, A.; Herschtal, A.; Foroudi, F. [Department of Physical Sciences, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002 (Australia); Nursing Service, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002 (Australia); Department of Radiation Oncology, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria 3002 (Australia); Department of Physical Sciences, Peter MacCallum Cancer Centre and Royal Melbourne Insititute of Technology, Melbourne, Victoria 3000 (Australia); Department of Biostatistics and Clinical Trials, Peter MacCallum Cancer Centre, Melbourne, Victoria 3002 (Australia); Department of Radiation Oncology, Peter MacCallum Cancer Centre and University of Melbourne, Melbourne, Victoria 3010 (Australia)

    2011-11-15

    Purpose: To quantify movement of prostate cancer patients undergoing treatment, using an in-house developed motion sensor in order to determine a relationship between patient movement and high dose rate (HDR) brachytherapy implant displacement. Methods: An electronic motion sensor was developed based on a three axis accelerometer. HDR brachytherapy treatment for prostate is delivered at this institution in two fractions 24 h apart and 22 patients were monitored for movement over the interval between fractions. The motion sensors functioned as inclinometers, monitoring inclination of both thighs, and the inclination and roll of the abdomen. The implanted HDR brachytherapy catheter set was assessed for displacement relative to fiducial markers in the prostate. Angle measurements and angle differences over a 2 s time base were binned, and the standard deviations of the resulting frequency distributions used as a metric for patient motion in each monitored axis. These parameters were correlated to measured catheter displacement using regression modeling. Results: The mean implant displacement was 12.6 mm in the caudal direction. A mean of 19.95 h data was recorded for the patient cohort. Patients generally moved through a limited range of angles with a mean of the exception of two patients who spent in excess of 2 h lying on their side. When tested for a relationship between movement in any of the four monitored axes and the implant displacement, none was significant. Conclusions: It is not likely that patient movement influences HDR prostate implant displacement. There may be benefits to patient comfort if nursing protocols were relaxed to allow patients greater freedom to move while the implant is in situ.

  9. How do ants make sense of gravity? A Boltzmann Walker analysis of Lasius niger trajectories on various inclines.

    Directory of Open Access Journals (Sweden)

    Anaïs Khuong

    Full Text Available The goal of this study is to describe accurately how the directional information given by support inclinations affects the ant Lasius niger motion in terms of a behavioral decision. To this end, we have tracked the spontaneous motion of 345 ants walking on a 0.5×0.5 m plane canvas, which was tilted with 5 various inclinations by [Formula: see text] rad ([Formula: see text] data points. At the population scale, support inclination favors dispersal along uphill and downhill directions. An ant's decision making process is modeled using a version of the Boltzmann Walker model, which describes an ant's random walk as a series of straight segments separated by reorientation events, and was extended to take directional influence into account. From the data segmented accordingly ([Formula: see text] segments, this extension allows us to test separately how average speed, segments lengths and reorientation decisions are affected by support inclination and current walking direction of the ant. We found that support inclination had a major effect on average speed, which appeared approximately three times slower on the [Formula: see text] incline. However, we found no effect of the walking direction on speed. Contrastingly, we found that ants tend to walk longer in the same direction when they move uphill or downhill, and also that they preferentially adopt new uphill or downhill headings at turning points. We conclude that ants continuously adapt their decision making about where to go, and how long to persist in the same direction, depending on how they are aligned with the line of maximum declivity gradient. Hence, their behavioral decision process appears to combine klinokinesis with geomenotaxis. The extended Boltzmann Walker model parameterized by these effects gives a fair account of the directional dispersal of ants on inclines.

  10. A TLD reader for wide range in situ dose measurement

    International Nuclear Information System (INIS)

    Deme, S; Apathy, I.; Bodnar, L.; Csoeke, A.; Hejja, I.

    1998-01-01

    A portable thermoluminescent dosemeter reader suitable for reading at the site of exposure is described. The instrument consists of a glass bulb containing the CaSO 4 :Dy thermoluminescent material laminated to the surface of an electrically heated resistive metal plate. The bulb is encapsulated in a cylindrical, pen-like metal holder made of aluminium. A one-wire-port integrated electronic programmable memory chip mounted inside the holder contains the identification code and the individual calibration parameters of the dosemeter. The aperture of the holder is normally covered by a stainless steel tube to protect the bulb from light and mechanical shocks. The tube slips backwards automatically when the dosemeter is inserted into the reader. The system is used by the Hungarian nuclear power plant. (M.D.)

  11. Organ Doses and Effective Doses in Pediatric Radiography: Patient-Dose Survey in Finland

    Energy Technology Data Exchange (ETDEWEB)

    Kiljunen, T.; Tietaevaeinen, A.; Parviainen, T.; Viitala, A.; Kortesniemi, M. (Radiation Practices Regulation, Radiation and Nuclear Safety Authority, Helsinki (Finland))

    2009-01-15

    Background: Use of the effective dose in diagnostic radiology permits the radiation exposure of diverse diagnostic procedures to be quantified. Fundamental knowledge of patient doses enhances the implementation of the 'as low as reasonably achievable' (ALARA) principle. Purpose: To provide comparative information on pediatric examination protocols and patient doses in skull, sinus, chest, abdominal, and pelvic radiography examinations. Material and Methods: 24 Finnish hospitals were asked to register pediatric examination data, including patient information and examination parameters and specifications. The total number of examinations in the study was 1916 (1426 chest, 228 sinus, 96 abdominal, 94 skull, and 72 pelvic examinations). Entrance surface dose (ESD) and dose-area products (DAP) were calculated retrospectively or DAP meters were used. Organ doses and effective doses were determined using a Monte Carlo program (PCXMC). Results: There was considerable variation in examination protocols between different hospitals, indicating large variations in patient doses. Mean effective doses of different age groups ranged from 5 muSv to 14 muSv in skull and sinus examinations, from 25 muSv to 483 muSv in abdominal examinations, and from 6 muSv to 48 muSv in chest examinations. Conclusion: In chest and sinus examinations, the amount of data was extensive, allowing national pediatric diagnostic reference levels to be defined. Parameter selection in pediatric examination protocols should be harmonized in order to reduce patient doses and improve optimization

  12. Estimate of the magnetic anisotropy effect on the archaeomagnetic inclination of ancient bricks

    Science.gov (United States)

    Tema, Evdokia

    2009-10-01

    The magnetic fabric of 59 bricks coming from 5 ancient kilns has been studied by measuring the anisotropy of magnetic susceptibility (AMS) and the anisotropy of isothermal (AIRM), anhysteretic (AARM) and thermal (ATRM) remanent magnetization. The bricks are characterized by a well developed magnetic fabric that matches their flat shape. The shape of the anisotropy ellipsoids is in almost all cases oblate with the maximum and intermediate axes lying parallel to the large face of the brick and the minimum axis perpendicular to it. The directions of the principal axes are almost the same irrespectively of the type of anisotropy measured, whereas the degree of anisotropy of the AIRM, AARM and ATRM is much higher than the AMS. As the bricks lie horizontally within the kiln, the planar magnetic fabric results in an inclination shallowing of the archaeomagnetic direction with respect to that of the Earth's magnetic field at the time of their last cooling. Estimation of this effect on the grounds of ATRM measurements yields a shallowing that varies from 4° to 10° for individual samples. Such inclination difference may significantly bias archeomagnetic dating; for the case of the Canosa late-Roman kiln it leads to a dating error of more than two centuries.

  13. Lower limb joint forces during walking on the level and slopes at different inclinations.

    Science.gov (United States)

    Alexander, Nathalie; Schwameder, Hermann

    2016-03-01

    Sloped walking is associated with an increase of lower extremity joint loading compared to level walking. Therefore, the aim of this study was to analyse lower limb joint compression forces as well as tibiofemoral joint shear forces during sloped walking at different inclinations. Eighteen healthy male participants (age: 27.0 ± 4.7 years, height: 1.80 ± 0.05 m, mass: 74.5 ± 8.2 kg) were asked to walk at a pre-set speed of 1.1m/s on a ramp (6 m × 1.5 m) at the slopes of -18°, -12°, -6°, 0°, 6°, 12° and 18°. Kinematic data were captured with a twelve-camera motion capture system (Vicon). Kinetic data were recorded with two force plates (AMTI) imbedded into a ramp. A musculoskeletal model (AnyBody) was used to compute lower limb joint forces. Results showed that downhill walking led to significantly increased hip, tibiofemoral and patellofemoral joint compression forces (pforces (pforces with increasing inclination (pforces did not increase with the gradient. Due to diverse tibiofemoral joint shear force patterns in the literature, results should be treated with caution in general. Finally, lower limb joint force analyses provided more insight in the structure loading conditions during sloped walking than joint moment analyses. Copyright © 2016 Elsevier B.V. All rights reserved.

  14. DEM simulation of flow of dumbbells on a rough inclined plane

    Science.gov (United States)

    Mandal, Sandip; Khakhar, Devang

    2015-11-01

    The rheology of non-spherical granular materials such as food grains, sugar cubes, sand, pharmaceutical pills, among others, is not understood well. We study the flow of non-spherical dumbbells of different aspect ratios on a rough inclined plane by using soft sphere DEM simulations. The dumbbells are generated by fusing two spheres together and a linear spring dashpot model along with Coulombic friction is employed to calculate inter-particle forces. At steady state, a uni-directional shear flow is obtained which allows for a detailed study of the rheology. The effect of aspect ratio and inclination angle on mean velocity, volume fraction, shear rate, shear stress, pressure and viscosity profiles is examined. The effect of aspect ratio on probability distribution of angles, made by the major axes of the dumbbells with the flow direction, average angle and order parameter is analyzed. The dense flow rheology is well explained by Bagnold's law and the constitutive laws of JFP model. The dependencies of first and second normal stress differences on aspect ratio are studied. The probability distributions of translational and rotational velocity are analyzed.

  15. An analytic solution of the static problem of inclined risers conveying fluid

    KAUST Repository

    Alfosail, Feras

    2016-05-28

    We use the method of matched asymptotic expansion to develop an analytic solution to the static problem of clamped–clamped inclined risers conveying fluid. The inclined riser is modeled as an Euler–Bernoulli beam taking into account its self-weight, mid-plane stretching, an applied axial tension, and the internal fluid velocity. The solution consists of three parts: an outer solution valid away from the two boundaries and two inner solutions valid near the two ends. The three solutions are then matched and combined into a so-called composite expansion. A Newton–Raphson method is used to determine the value of the mid-plane stretching corresponding to each applied tension and internal velocity. The analytic solution is in good agreement with those obtained with other solution methods for large values of applied tensions. Therefore, it can be used to replace other mathematical solution methods that suffer numerical limitations and high computational cost. © 2016 Springer Science+Business Media Dordrecht

  16. Effect of incisor inclination changes on cephalometric points a and b

    International Nuclear Information System (INIS)

    Hassan, S.; Shaikh, A.; Fida, M.

    2015-01-01

    The position of cephalometric points A and B are liable to be affected by alveolar remodelling caused by orthodontic tooth movement during incisor retraction. This study was conducted to evaluate the change in positions of cephalometric points A and B in sagittal and vertical dimensions due to change in incisor inclinations. Methods: Total sample of 31 subjects were recruited into the study. The inclusion criteria were extraction of premolars in upper and lower arches, completion of growth and orthodontic treatment. The exclusion criteria were patients with craniofacial anomalies and history of orthodontic treatment. By superimposition of pre and post treatment tracings, various linear and angular parameters were measured. Various tests and multiple linear regression analysis were performed to determine changes in outcome variables. Statistically significant p-value was <0.05. Results:One-sample t-test showed that change in position of only point A was statistically significant which was 1.61mm (p<0.01) in sagittal direction and 1.49mm (p<0.01) in vertical direction. Multiple linear regression analysis showed that if we retrocline upper incisor by 100, the point A will move superiorly by 0.6mm. Conclusions: Total change in the position of point A is in a downward and forward direction. Total Change in upper incisors inclinations causes change in position of point A only in vertical direction. (author)

  17. Laboratory experiments on the interaction between inclined negatively buoyant jets and regular waves

    Directory of Open Access Journals (Sweden)

    Ferrari Simone

    2015-01-01

    Full Text Available In this paper we present the results from a series of laboratory experiments on inclined negatively buoyant jets released in a receiving environment with waves. This simulates the case, typical of many practical applications, of the sea discharge of fluids denser than the receiving environment, as in the case of the brine from a desalination plant. The experiments were performed employing a Light Induced Fluorescence (LIF technique, in order to measure the concentration fields. Both the jet and the wave motion features were varied, in order to simulate a typical discharge into the Mediterranean Sea. Reference discharges in a stagnant environment were performed as well. The jet behaviour was analyzed from a statistical point of view, both considering the global phenomenon and its single phases. The influence of the wave motion on the inclined negatively buoyant jet geometry and dilution turns out to be a combined action of a split into two branches of the jet and a rotation. Their combined action decreases the jet maximum height and the impact distance, and is the main cause for the higher dilution reached in a wavy environment.

  18. Electric field effects on the dynamics of bubble detachment from an inclined surface

    International Nuclear Information System (INIS)

    Di Marco, P; Morganti, N; Saccone, G

    2015-01-01

    An experimental apparatus to study bubble detachment from an inclined surface under the action of electric forces is described. It consists of a container filled with FC72 at room temperature and pressure where a train of gas bubbles is injected from an orifice. An electrostatic field can be imposed around the bubble, while the cell can be tilted from 0 to 90°. It is possible to study interface growth with the aid of high-speed cinematography. Since the interface is asymmetrical, a mirror system allowed to acquire, in the same frame, two images at 90° of the bubble. Different inclinations, injection rates and voltages were tested in order to couple the effects of shear gravity and electric field. Curvature and contact angles have been derived with appropriate interpolation methods of the profile. Force balances on the bubble were checked, finding an electric force, which, at first pulls the bubbles from the orifice, then pushes it against the surface. The motion of the center of gravity confirms this behaviour. A power balance has been developed to determine the energy contributions, revealing that surface growth incorporates both the effects of inlet power and electric field. (paper)

  19. Vibration Analysis of Inclined Laminated Composite Beams under Moving Distributed Masses

    Directory of Open Access Journals (Sweden)

    E. Bahmyari

    2014-01-01

    Full Text Available The dynamic response of laminated composite beams subjected to distributed moving masses is investigated using the finite element method (FEM based on the both first-order shear deformation theory (FSDT and the classical beam theory (CLT. Six and ten degrees of freedom beam elements are used to discretize the CLT and FSDT equations of motion, respectively. The resulting spatially discretized beam governing equations including the effect of inertial, Coriolis, and centrifugal forces due to moving distributed mass are evaluated in time domain by applying Newmark’s scheme. The presented approach is first validated by studying its convergence behavior and comparing the results with those of existing solutions in the literature. Then, the effect of incline angle, mass, and velocity of moving body, layer orientation, load length, and inertial, Coriolis, and centrifugal forces due to the moving distributed mass and friction force between the beam and the moving distributed mass on the dynamic behavior of inclined laminated composite beams are investigated.

  20. Dynamic Fracturing Behavior of Layered Rock with Different Inclination Angles in SHPB Tests

    Directory of Open Access Journals (Sweden)

    Jiadong Qiu

    2017-01-01

    Full Text Available The fracturing behavior of layered rocks is usually influenced by bedding planes. In this paper, five groups of bedded sandstones with different bedding inclination angles θ are used to carry out impact compression tests by split Hopkinson pressure bar. A high-speed camera is used to capture the fracturing process of specimens. Based on testing results, three failure patterns are identified and classified, including (A splitting along bedding planes; (B sliding failure along bedding planes; (C fracturing across bedding planes. The failure pattern (C can be further classified into three subcategories: (C1 fracturing oblique to loading direction; (C2 fracturing parallel to loading direction; (C3 mixed fracturing across bedding planes. Meanwhile, a numerical model of layered rock and SHPB system are established by particle flow code (PFC. The numerical results show that the shear stress is the main reason for inducing the damage along bedding plane at θ = 0°~75°. Both tensile stress and shear stress on bedding planes contribute to the splitting failure along bedding planes when the inclination angle is 90°. Besides, tensile stress is the main reason that leads to the damage in rock matrixes at θ = 0°~90°.