Methylbutylmalonamide as an extractant for U(VI), Pu(IV), and Am(III)

International Nuclear Information System (INIS)

Nair, G.M.; Prabhu, D.R.; Mahajan, G.R.

1994-01-01

The unsymmetrical diamide methylbutylmalonamide has been synthesized and used in the extraction of U(VI), Pu(IV), and Am(III) in benzene medium. The distribution ratio for three cations was found to increase with increasing aqueous nitric acid concentration. U(VI) and Pu(IV) were found to be extracted as disolvates while Am(III) as a trisolvate. The thermodynamic parameters determined by the temperature variation method showed the extraction reactions to be mainly enthalphy-controlled. Am(III) was found to be back-extracted with dilute nitric acid, while Pu(IV) by dilute nitric acid - hydrofluoric acid mixture and U(VI) by dilute sodium carbonate solution. (author) 6 refs.; 3 figs.; 2 tabs

Synthesis and reactivity of triscyclopentadienyl uranium (III) and (IV) complexes

International Nuclear Information System (INIS)

Berthet, J.C.

1992-01-01

The reactions of (RC 5 H 4 ) 3 U with R=trimethylsilylcyclopentadienyl or tertiobutylcyclopentadienyl are studied for the synthesis of new uranium organometallic compounds. Reactions with sodium hydride are first described uranium (III) anionic hydrides obtained are oxidized for synthesis of stable uranium (IV) organometallic hydrides. Stability of these compounds is discussed. Reactivity of these uranium (III) and (IV) hydrides are studied. Formation of new binuclear compounds with strong U-O and U-N bonds is examined and crystal structure are presented. Monocyclooctatetraenylic uranium complexes are also investigated

The Uptake of Eu(III) and Th(IV) by Calcite under Hyperalkaline Conditions

Energy Technology Data Exchange (ETDEWEB)

Tits, J.; Wieland, E.; Bradbury, M.H.; Eckert, P.; Schaible, A

2002-10-01

Calcite is an important component of Valanginian marl, a potential host rock for a low and intermediate level radioactive waste (L/ILW) repository in Switzerland. This mineral also forms an important component of the disturbed zone around a repository, as it remains largely unaffected by the hyperalkaline waters migrating out of the cementitious repository . The sorption behaviour of Eu(III) and Th(IV) on Merck calcite in an artificial cement pore water (ACW) at pH 13.3 has been studied in batch-type sorption experiments. In addition, the effect of {alpha}-isosaccharinic acid (ISA) and gluconic acid (GLU) on the sorption of these two cations has been investigated. In the absence of ISA and GLU, a strong interaction of Eu(III) and Th(IV) with Merck calcite was observed. Eu(III) and Th(IV) sorption kinetics were fast and the isotherms indicated a linear adsorption behaviour over the experimentally accessible concentration range. In the case of Eu(III), a decrease of the R{sub d} value with increasing solid to liquid (S:L) ratio was observed indicating that, along with adsorption, other processes might influence the immobilisation of this cation by Merck calcite under ACW conditions. In the case of Th(IV), however, changes in the S:L ratio had no effect on the sorption behaviour . High ISA and GLU concentrations in solution significantly affected the sorption of both Eu(III) and Th(IV): R{sub d} values for Eu(III) decreased significantly at ISA concentrations higher than 10{sup -5} M and at GLU concentrations higher than 10{sup -7} M. The sorption of Th(IV) was reduced at ISA concentrations above 2.10{sup -5} M and at GLU concentrations above 10{sup -6} M. The effects of ISA and GLU on the immobilisation of Eu(III) and Th(IV) were interpreted in terms of complex formation in solution. In the case of Eu(III) the metal ligand complexes were found to have a 1 : 1 stoichiometry. Complexation constants derived for the aqueous Eu(III)-ISA. and Eu(III)GLU complexes were

Determination of the solubility of Np(IV), Pu(III) - (VI),Am(III) - (VI), and Te(IV), (V) hydroxo compounds in 0.5 - 14 M NaOH solutions

Energy Technology Data Exchange (ETDEWEB)

Delegard, C.H.

1996-09-24

The solubilities of Am(III), Np(IV), Pu(IV), Tc(IV), Np(V), Pu(V), Am(V), and Tc(V) hydroxo compounds were studied in 0.5 to 14 M NaOH solutions at 25{+-}2 {degrees}C. The effects of fluoride, phosphate, carbonate, oxalate, and some other organic complexing agents on the solubilities of Np(IV), Pu(IV), and TC(IV) hydroxides were investigated at 1.0 and 4.0 M NAOH. Some predictions were made on the dissolved (I.V) and (V) species present in alkali solutions.

[Diagnostic values of serum type III procollagen N-terminal peptide in type IV gastric cancer].

Science.gov (United States)

Akazawa, S; Fujiki, T; Kanda, Y; Kumai, R; Yoshida, S

1985-04-01

Since increased synthesis of collagen has been demonstrated in tissue of type IV gastric cancer, we attempted to distinguish type IV gastric cancer from other cancers by measuring serum levels of type III procollagen N-terminal peptide (type III-N-peptide). Mean serum levels in type IV gastric cancer patients without metastasis were found to be elevated above normal values and developed a tendency to be higher than those in types I, II and III gastric cancer patients without metastasis. Highly positive ratios were found in patients with liver diseases including hepatoma and colon cancer, biliary tract cancer, and esophageal cancer patients with liver, lung or bone metastasis, but only 2 out of 14 of these cancer patients without such metastasis showed positive serum levels of type III-N-peptide. Positive cases in patients with type IV gastric cancer were obtained not only in the group with clinical stage IV but also in the groups with clinical stages II and III. In addition, high serum levels of type III-N-peptide in patients with type IV gastric cancer were seen not only in the cases with liver, lung or bone metastasis but also in cases with disseminated peritoneal metastasis alone. These results suggest that if the serum level of type III-N-peptide is elevated above normal values, type IV gastric cancer should be suspected after ruling out liver diseases, myelofibrosis and liver, lung or bone metastasis.

Satellitenbewegung, band III: Natiirliche und gesteuerte bewegung.

Science.gov (United States)

Jochim, E. F.

2014-12-01

Im dritten Band der Satellitenbewegung werden in fortlaufender Nummerierung einige für Untersuchungen der Bewegung der künstlichen Satelliten wichtige Grundlagen der Astrodynamik mit ausführlichen mathematischen Formelsystemen behandelt. Dazu zählen die unterschiedlichen Aspekte der Bewegung der natürlichen Himmelskörper, die Steuerung und Kontrolle von künstlichen Objekten, und insbesondere die für eine Satellitenbahnanalyse wichtigen physikalischen Beeinflussungen einer Satellitenbewegung. Mathematisch entscheidend ist die Wahl geeigneter Bahnparameter, die ein bestimmtes Bewegungsproblem widerspruchsfrei und singularitätenfrei zu behandeln gestatten. Für die Behandlung routinemäßiger Aufgabenstellungen der Satellitenbewegung, in erster Linie einer präzisen Bahnbestimmung und Bahnverbesserung, kann auf eine Fülle von lehrbuchartigen Monographien verwiesen werden, so dass diese Problematik in der vorliegenden Arbeit nur angedeutet werden soll.

Initial experience with locoregional radioimmunotherapy using {sup 131}I-labelled monoclonal antibodies against tenascin (BC-4) for treatment of glioma (WHO III and IV)

Energy Technology Data Exchange (ETDEWEB)

Poepperl, G.; Gildehaus, F.J.; Hahn, K.; Tatsch, K. [Klinik und Poliklinik fuer Nuklearmedizin, Klinikum Grosshadern, Muenchen (Germany); Goetz, C.; Reulen, H.J. [Klinik und Poliklinik fuer Neurochirurgie, Klinikum Grosshadern, Muenchen (Germany); Yousry, T.A. [Inst. fuer Neuroradiologie der LMU Muenchen, Klinikum Grosshadern, Muenchen (Germany)

2002-06-01

of activity within the resection cavity and low systemic toxicity. (orig.) [German] Ziel: Bei der Standardtherapie von Gliomen (Resektion, Radiatio, Chemotherapie) ist die Prognose sehr schlecht. Ein neuer Therapieansatz besteht in der additiven lokalen Radioimmuntherapie (RIT) mit {sup 131}I-markierten Tenascin-Antikoerpern (BC-4). Diese Studie berichtet ueber unsere initialen Erfahrungen hinsichtlich Nebenwirkungen, Biokinetik und klinischem Verlauf. Methoden: Zwoelf Patienten (4 Gliome WHO III, 8 Gliome WHO IV) erhielten nach Operation und perkutaner Radiatio 1-5 RIT-Zyklen im Abstand von 6 Wochen mit durchschnittlich 1100 MBq {sup 131}I-markierten Antikoerpern ueber ein Ommaya-Reservoir. Der Verlauf wurde durch FDG-PET- und MRT-Untersuchungen dokumentiert. Die Biokinetic wurde an Ganzkoerperaufnahmen, Blut- und Urinproben sowie Proben aus der Tumorhoehle nach RIT beurteilt. Ergebnisse: Unter RIT traten bei vier Patienten passagere Anfaelle, bei einem in Kombination mit transienter Sprachstoerung auf. Acht Patienten bildeten im Verlauf HAMAs (humane Antikoerper gegen Mausantigen) aus. Die biologische HWZ der Aktivitaet in der Turmorhoehle lag im Mittel bei 3,9 d (1,0-10,2 d) und blieb intraindividuell bei Folgetherapien konstant. Das Radioimmunkonjugat in der Tumorhoehle blieb mindestens 5 d stabil. Die mittlere Ueberlebenszeit liegt zurzeit bei 18,5 Monaten und ist damit deutlich hoeher als bei einer historischen Patientengruppe mit Standardtherapie (9,7 Monate; n=89). Fuenf Patienten zeigen bisher keinen Hinweis auf ein Rezidiv. Bei drei Patienten mit einem Tumorrest nach Operation zeigte sich unter RIT in einem Fall partielle Remission, ein stabiler und ein progredienter Krankheitsverlauf. Vier Patienten ohne Tumorrest zu Therapiebeginn entwickelten unter Therapie ein Rezidiv. Schlussfolgerungen: Erste Erfahrungen mit der lokalen RIT zeigen, dass diese komplikationsarme Therapieform additiv zur Standardtherapie ein Erfolg versprechender Ansatz bei malignem

Diversität und Konvergenz an der Wurzel: Perspektiven der Romanistik in Zeiten der Globalisierung

Directory of Open Access Journals (Sweden)

Bernhard Teuber

2016-03-01

Full Text Available I. Wieder eine Studienreform – II. Diversitäten und Konvergenz – III. Die fetten Jahre der Theorie – IV. Was in Zukunft zu tun bleibt: 1.Digital Humanities; 2.Spatial Turn; 3.Postcolonial Studies; 4.Gender Studies; 5.Ethical Turn – V. Averroes auf der Suche

Explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems.

Science.gov (United States)

Kong, Fang; Hu, Chun-Li; Hu, Ting; Zhou, Yong; Mao, Jiang-Gao

2009-07-07

Systematic explorations of new phases in the Ga(III)/In(III)-Mo(VI)-Se(IV)/Te(IV)-O systems by hydrothermal syntheses or solid-state reactions at high-temperature led to four new quaternary compounds, namely, Ga(2)MoQ(2)O(10) (Q = Se, Te), In(2)Mo(2)Se(2)O(13)(H(2)O) and In(2)MoTe(2)O(10). Ga(2)MoQ(2)O(10) (Q = Se, Te) are isostructural and their structures feature a 3D network of gallium selenite/tellurite with 12-member ring tunnels along b-axis, the distorted MoO(6) octahedra are attached on the wall of the above tunnels. The structure of In(2)Mo(2)Se(2)O(13)(H(2)O) features a new pillared-layered architecture composed of 2D indium(III) selenite layers that are interconnected by Mo(2)O(10) dimers, forming 8-membered ring tunnels along the b-axis. The structure of In(2)MoTe(2)O(10) features a 2D indium oxide layer formed by corner- and edge-sharing InO(6) and InO(7) polyhedra with MoO(4) tetrahedra and TeO(n) (n = 4, 5) polyhedra hanging on both sides of the layer, there are weak interlayer Te-O bonds of 2.512 A. Results of optical diffuse reflectance spectrum measurements indicate that all four compounds are insulators, which are in agreement with results of band structure calculations based on DFT methods.

Interventional therapy of hilar cholangiocarcinoma in type III and IV

International Nuclear Information System (INIS)

Fan Weijun; Wu Peihong; Zhang Liang; Huang Jinhua; Zhang Fujun; Gu Yangkui; Zhao Ming; Huang Xianglong; Guo Changyu

2005-01-01

Objective: To explore the role of synthetic interventional therapy for hilar cholangiocarcinoma in type III and IV. Methods: Twenty-one patients with obstructive cholestasis were pathological confirmed as cholangioadenocarcinoma, and they were classified as type III and IV cholangioadenocarcinoma by CT, MRCP, and percutaneous transhepatic cholangiography. Percutaneous transhepatic cholangiography with internal and external drainage (PTCD), multipolar radiofrequency (RF) ablation, biliary stent endoprosthesis, and interventional adjuvant chemotherapy were applied sequentially. Results: All masses presented with density diminution in CT one month after RF ablation, in which 13 masses had about 30% reduction in size, 4 masses had about 20% reduction in size, and 4 masses remained unchanged. All the masses presented with size reduction with an average of 37% in follow-up CT after 6 months, and the most remarkable size reduction was 60%. The direct and indirect bilirubin levels prompt returned to normal range in 17 cases one month after synthetic interventional therapy and returned to normal range in all cases 6 months later. All patients survived with the follow-up period ranging from 9 to 24 months, with the mean survival time of 14 months. Conclusion: Synthetic interventional therapy is a micro-invasive and effective treatment for type III and IV cholangiocarcinoma. (authors)

Transferable tight-binding model for strained group IV and III-V materials and heterostructures

Science.gov (United States)

Tan, Yaohua; Povolotskyi, Michael; Kubis, Tillmann; Boykin, Timothy B.; Klimeck, Gerhard

2016-07-01

It is critical to capture the effect due to strain and material interface for device level transistor modeling. We introduce a transferable s p3d5s* tight-binding model with nearest-neighbor interactions for arbitrarily strained group IV and III-V materials. The tight-binding model is parametrized with respect to hybrid functional (HSE06) calculations for varieties of strained systems. The tight-binding calculations of ultrasmall superlattices formed by group IV and group III-V materials show good agreement with the corresponding HSE06 calculations. The application of the tight-binding model to superlattices demonstrates that the transferable tight-binding model with nearest-neighbor interactions can be obtained for group IV and III-V materials.

Cost analysis of surgically treated pressure sores stage III and IV.

Science.gov (United States)

Filius, A; Damen, T H C; Schuijer-Maaskant, K P; Polinder, S; Hovius, S E R; Walbeehm, E T

2013-11-01

Health-care costs associated with pressure sores are significant and their financial burden is likely to increase even further. The aim of this study was to analyse the direct medical costs of hospital care for surgical treatment of pressure sores stage III and IV. We performed a retrospective chart study of patients who were surgically treated for stage III and IV pressure sores between 2007 and 2010. Volumes of health-care use were obtained for all patients and direct medical costs were subsequently calculated. In addition, we evaluated the effect of location and number of pressure sores on total costs. A total of 52 cases were identified. Average direct medical costs in hospital were €20,957 for the surgical treatment of pressure sores stage III or IV; average direct medical costs for patients with one pressure sore on an extremity (group 1, n = 5) were €30,286, €10,113 for patients with one pressure sore on the trunk (group 2, n = 32) and €40,882 for patients with multiple pressure sores (group 3, n = 15). The additional costs for patients in group 1 and group 3 compared to group 2 were primarily due to longer hospitalisation. The average direct medical costs for surgical treatment of pressure sores stage III and IV were high. Large differences in costs were related to the location and number of pressure sores. Insight into the distribution of these costs allows identification of high-risk patients and enables the development of specific cost-reducing measures. Copyright © 2013 British Association of Plastic, Reconstructive and Aesthetic Surgeons. Published by Elsevier Ltd. All rights reserved.

Level III and IV Ecoregions of the Continental United States

Science.gov (United States)

Information and downloadable maps and datasets for Level III and IV ecoregions of the continental United States. Ecoregions are areas of general similarity in the type, quality, and quantity of environmental resources.

Sequential heavy metal extraction from dust precipitates and road sediments. Part 2. Sequential heavy metal extraction from urban dust; Sequentielle Schwermetallextraktion aus Staubniederschlaegen und Strassensedimenten. T. 2. Sequentielle Schwermetallextraktion von staedtischen Staeuben

Energy Technology Data Exchange (ETDEWEB)

Heiser, U.; Norra, S.; Stueben, D.; Wagner, M. von [Karlsruhe Univ. (T.H.) (Germany). Inst. fuer Petrographie und Geochemie

1999-03-01

For the application of our method for the sequential extraction of heavy metals from microsamples presented in part 1 (`Sequentielle Schwermetallextraktion von Mikroproben` - `Sequential Extraction of Heavy Metals from Micro Samples`) an investigation was carried out to evaluate airborne dust fallout and street sediments at two urban sites where different heavy metal immission rates occur due to traffic influence. In the street sediments the total concentrations of zinc, copper and lead was three to fivefold higher in the silt and clay fraction (<63 {mu}m) than in the particle size fraction (<1,12 mm), but showed nearly the same mobilisation behaviour. The dust samples showed equal mobilisation behaviour as the street sediments for copper and lead, while zinc was considerably more mobile in the dust samples: In extraction steps I-IV (I: mobile fraction; II: easily deliverable fraction; III: fraction bound to manganese oxides; IV: fraction bound organic to matter) zinc, copper and lead in street sediments, as well as copper and lead in dust samples, were dissolved to 40-70%, whereas about 80% of zinc in the dust samples was already dissolved in extraction step I. (orig.) [Deutsch] Mit Hilfe des in Teil 1 (`Sequentielle Schwermetallextraktion von Mikroproben`) vorgestellten Verfahrens zur sequentiellen Schwermetallextraktion von Mikroproben wurden die Mobilisierbarkeiten von Zink, Kupfer und Blei aus Staubniederschlaegen und aus der Schluff- und Tonfraktion von Strassensedimenten an zwei urbanen Standorten mit unterschiedlicher, verkehrsbedingter Schwermetallbelastung untersucht und miteinander verglichen. In Strassensedimenten wiesen Zink, Kupfer und Blei in der Schluff- und Tonfraktion drei- bis fuenffach hoehere Gesamtgehalte auf als die Korngroessenfraktion <1,12 mm, zeigten aber aehnliches Verhalten in der Mobilisierbarkeit. Bei den Staubproben war die Mobilisierbarkeit von Kupfer und Blei aehnlich wie in den Strassensedimenten, waehrend sich Zink als erheblich

U.S. Level III and IV Ecoregions (U.S. EPA)

Data.gov (United States)

U.S. Environmental Protection Agency — This map service displays Level III and Level IV Ecoregions of the United States and was created from ecoregion data obtained from the U.S. Environmental Protection...

Neuausrichtung und Konsolidierung

Science.gov (United States)

Grohmann, Heinz

Mit der Wahl von Wolfgang Wetzel zum Vorsitzenden der Deutschen Statistischen Gesellschaft im Jahre 1972 begann eine 32jährige Ära, in der die praktische und die theoretische Statistik in einem ausgewogenen Verhältnis gepflegt wurden. Ein regelmäßiger vierjähriger Wechsel im Vorsitz stärkte die Gemeinschaft und die praktische wie die wissenschaftliche Arbeit gleichermaßen. Die jährlichen Hauptversammlungen behandelten gesellschaftlich aktuelle wie zukunftsorientierte Themen, und die Ausschüsse sowie weitere Veranstaltungen gaben Gelegenheit zur Förderung und Pflege einer Vielzahl von Arbeitsgebieten der Statistik. Darüber wird nicht nur in diesem Kapitel, sondern auch in den Teilen II und III des Bandes berichtet.

Ce(III)/Ce(IV) in methanesulfonic acid as the positive half cell of a redox flow battery

International Nuclear Information System (INIS)

Leung, P.K.; Ponce de Leon, C.; Low, C.T.J.; Walsh, F.C.

2011-01-01

The characteristics of the Ce(III)/Ce(IV) redox couple in methanesulfonic acid were studied at a platinum disk electrode (0.125 cm 2 ) over a wide range of electrolyte compositions and temperatures: cerium (III) methanesulfonate (0.1-1.2 mol dm -3 ), methanesulfonic acid (0.1-5.0 mol dm -3 ) and electrolyte temperatures (295-333 K). The cyclic voltammetry experiments indicated that the diffusion coefficient of Ce(III) ions was 0.5 x 10 -6 cm 2 s -1 and that the electrochemical kinetics for the oxidation of Ce(III) and the reduction of Ce(IV) was slow. The reversibility of the redox reaction depended on the electrolyte composition and improved at higher electrolyte temperatures. At higher methanesulfonic acid concentrations, the degree of oxygen evolution decreased by up to 50% when the acid concentration increased from 2 to 5 mol dm -3 . The oxidation of Ce(III) and reduction of Ce(IV) were also investigated during a constant current batch electrolysis in a parallel plate zinc-cerium flow cell with a 3-dimensional platinised titanium mesh electrode. The current efficiencies over 4.5 h of the process Ce(III) to Ce(IV) and 3.3 h electrolysis of the reverse reaction Ce(IV) to Ce(III) were 94.0 and 97.6%, respectively. With a 2-dimensional, planar platinised titanium electrode (9 cm 2 area), the redox reaction of the Ce(III)/Ce(IV) system was under mass-transport control, while the reaction on the 3-dimensional mesh electrode was initially under charge-transfer control but became mass-transport controlled after 2.5-3 h of electrolysis. The effect of the side reactions (hydrogen and oxygen evolution) on the current efficiencies and the conversion of Ce(III) and Ce(IV) are discussed.

Effect of HCl Concentration on the Oxidation of LIX 63 and the Subsequent Separation of Pd(II), Pt(IV), Ir(IV) and Rh(III) by Solvent Extraction

Energy Technology Data Exchange (ETDEWEB)

Nguyen, Thi Hong; Lee, Man Seung [Mokpo National University, Jeollanamdo (Korea, Republic of)

2016-10-15

During the selective extraction of Pd(II) by LIX 63 from 6 M HCl solutions containing platinum group metals, an oxidation-reduction reaction occurs between the LIX 63 and Ir(IV). Since the reduced Ir(III) cannot be extracted by solvating and amine extractants, the oxidation-reduction reaction has a significant effect on the separation of Pt(IV), Ir(IV) and Rh(III). Therefore, the effect of HCl concentration on the reduction of Ir(IV) during the extraction with LIX 63 was investigated at 3 and 6 M HCl solutions. The extraction behavior of Iridium by Aliquat 336 from the Pd(II) free raffinate showed that the percentage of iridium extraction rapidly decreased when HCl concentration was increased from 3 to 6 M, indicating that more Ir(IV) was reduced to Ir(III). Extraction schemes for the separation of Pt(IV), iridium and Rh(III) by Aliquat 336 from 3 and 6 M HCl solutions were investigated.

Transferable tight binding model for strained group IV and III-V heterostructures

Science.gov (United States)

Tan, Yaohua; Povolotskyi, Micheal; Kubis, Tillmann; Boykin, Timothy; Klimeck, Gerhard

Modern semiconductor devices have reached critical device dimensions in the range of several nanometers. For reliable prediction of device performance, it is critical to have a numerical efficient model that are transferable to material interfaces. In this work, we present an empirical tight binding (ETB) model with transferable parameters for strained IV and III-V group semiconductors. The ETB model is numerically highly efficient as it make use of an orthogonal sp3d5s* basis set with nearest neighbor inter-atomic interactions. The ETB parameters are generated from HSE06 hybrid functional calculations. Band structures of strained group IV and III-V materials by ETB model are in good agreement with corresponding HSE06 calculations. Furthermore, the ETB model is applied to strained superlattices which consist of group IV and III-V elements. The ETB model turns out to be transferable to nano-scale hetero-structure. The ETB band structures agree with the corresponding HSE06 results in the whole Brillouin zone. The ETB band gaps of superlattices with common cations or common anions have discrepancies within 0.05eV.

11-year field study of Pu migration from Pu III, IV, and VI sources

International Nuclear Information System (INIS)

Kaplan, D.I.; Serkiz, S.M.; Demirkanli, D.I.; Gumapas, L.; Fjeld, R.A.; Molz, F.J.; Powell, B.A.

2005-01-01

Full text of publication follows: Understanding the processes controlling Pu mobility in the subsurface environment is important for estimating the amount of Pu waste that can be safely disposed in vadose zone burial sites. To study long-term Pu mobility, four 52-L lysimeters filled with sediment collected from the Savannah River Site near Aiken South Carolina were amended with well characterized solid Pu sources (Pu III Cl 3 , Pu IV (NO 3 ) 4 , Pu IV (C 2 O 4 ) 2 , and Pu VI O 2 (NO 3 ) 2 ) and left exposed to natural precipitation for 2 to 11 years. Pu oxidation state distribution in the Pu(III) and Pu(IV) lysimeters sediments (a red clayey sediment, pH = 6.3) were similar, consisting of 0% Pu(III), >92% Pu(IV), 1% Pu(V), 1% Pu(VI), and the remainder was a Pu polymer. These three lysimeters also had near identical sediment Pu concentration profiles, where >95% of the Pu remained within 1.25 cm of the source after 11 years; moving at an overall rate of 0.9 cm yr -1 . As expected, Pu moved more rapidly through the Pu(VI) lysimeter, at an overall rate of 12.5 cm yr -1 . Solute transport modeling of the sediment Pu concentration profile data in the Pu(VI) lysimeter indicated that some transformation of Pu into a much less mobile form, presumably Pu(IV), had occurred during the course of the two year study. This modeling also supported previous laboratory measurements showing that Pu(V) or Pu(VI) reduction was five orders of magnitude faster than corresponding Pu(III) or Pu(IV) oxidation. The slow oxidation rate (1 x 10-8 hr -1 ; t 1/2 = 8,000 yr) was not discernable from the Pu(VI) lysimeter data that reflected only two years of transport but was readily discernable from the Pu(III) and Pu(IV) lysimeter data that reflected 11 yr of transport. (authors)

The dependence of C IV broad absorption line properties on accompanying Si IV and Al III absorption: relating quasar-wind ionization levels, kinematics, and column densities

Energy Technology Data Exchange (ETDEWEB)

Filiz Ak, N.; Brandt, W. N.; Schneider, D. P.; Trump, J. R. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Hall, P. B. [Department of Physics and Astronomy, York University, 4700 Keele Street, Toronto, Ontario M3J 1P3 (Canada); Anderson, S. F. [Astronomy Department, University of Washington, Seattle, WA 98195 (United States); Hamann, F. [Department of Astronomy, University of Florida, Gainesville, FL 32611-2055 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); Pâris, I. [Departamento de Astronomía, Universidad de Chile, Casilla 36-D, Santiago (Chile); Petitjean, P. [Institut d' Astrophysique de Paris, Universite Paris 6, F-75014 Paris (France); Ross, Nicholas P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 94720 (United States); Shen, Yue [Carnegie Observatories, 813 Santa Barbara Street, Pasadena, CA 91101 (United States); York, Don, E-mail: nfilizak@astro.psu.edu [Department of Astronomy and Astrophysics, The University of Chicago, Chicago, IL 60637 (United States)

2014-08-20

We consider how the profile and multi-year variability properties of a large sample of C IV Broad Absorption Line (BAL) troughs change when BALs from Si IV and/or Al III are present at corresponding velocities, indicating that the line of sight intercepts at least some lower ionization gas. We derive a number of observational results for C IV BALs separated according to the presence or absence of accompanying lower ionization transitions, including measurements of composite profile shapes, equivalent width (EW), characteristic velocities, composite variation profiles, and EW variability. We also measure the correlations between EW and fractional-EW variability for C IV, Si IV, and Al III. Our measurements reveal the basic correlated changes between ionization level, kinematics, and column density expected in accretion-disk wind models; e.g., lines of sight including lower ionization material generally show deeper and broader C IV troughs that have smaller minimum velocities and that are less variable. Many C IV BALs with no accompanying Si IV or Al III BALs may have only mild or no saturation.

Locally advanced breast cancer (stage III and stage IV)

International Nuclear Information System (INIS)

Baracat, F.F.; Grabert, H.; Lima, G.R. de; Pontes, M.; Ferraro, O.; Santana, A.; Brook, E.S.

1987-01-01

The results concerning to the treatment of 193 patients with locally advanced breast cancer-stage III and stage IV are analysed. All the patients were treated with radical radiotherapy plus total mastectomy about 6 weeks later; 53 pacients received also chemotherapy (CMF - 12 courses) and 52 were oophorectomized. (M.A.C) [pt

HYPERGLYCEMIA IN GRADE III AND GRADE IV MALNUTRITION WITH DEHYDRATING GASTROENTERITIS

Directory of Open Access Journals (Sweden)

Mallesh

2015-07-01

Full Text Available OBJECTIVE OF THE STUDY: To study the incidence of hyperglycemia in grade III AND IV malnutrition with no signs and some signs of dehydration. SETTING: Tertiary care center located in north Karnataka. DESIGN: Prospective observational study involving 21 children. METHODS: All the children with grade III and grade IV malnutrition presenting with diarrhea of less than 14 days duration, having no signs to some signs of dehydration. RESULTS: Hyperglycemia was observed in three of 21 children hypoglycemia was observed in six children. CONCLUSION: Although hypoglycemia is common finding in moderate and severely malnourished children with dehydrating gastroenteritis, hyperglycemia should also be suspected and treated. Long term follow up of these children is needed involving larger number of people in multicenter studies.

Ventas jurisdiccionales abulenses en tiempos de Felipe III y Felipe IV

Directory of Open Access Journals (Sweden)

Francisco Javier LORENZO PINAR

2009-12-01

Full Text Available RESUMEN: Este trabajo tiene por objeto dar a conocer las enajenaciones jurisdiccionales, —excluidas las ventas de oficios— llevadas a cabo por Felipe III y Felipe IV en la provincia de Ávila. Analiza las motivaciones de las ventas de lugares, el origen social de los compradores y las dificultades halladas por la Monarquía a la hora de llevar a cabo este proceso.ABSTRACT: This work tries to approach us to the territorial sales in Ávila —situated in the center of Spain— in the reigns of Philip III and Philip IV. It analyses the motivations, the social origin of the buyers and the difficulties found by the Monarchy when it wanted to manage this process.

A novel technique for the treatment of stages III to IV hemorrhoids

Science.gov (United States)

Lin, Guoqiang; Ge, Qiongxiang; He, Xiaokang; Qi, Haixin; Xu, Li

2017-01-01

Abstract To compare the efficacy of homemade anal cushion suspension clamp combined with harmonic scalpel (ACS) and Milligan–Morgan hemorrhoidectomy combined with electric knife (MMH) in the treatment of stages III to IV hemorrhoids. We conducted a retrospective study of 99 patients with stages III to IV hemorrhoids hospitalized from January to December in 2013. Among them, 51 patients were treated with ACS, while 48 patients received MMH. Data from clinical recording and follow-up included operative time, intraoperative blood loss, hospitalization information, postoperative pain, and postoperative complications. Operative time, intraoperative blood loss and hospitalization time in ACS group were significantly less than those in MMH group (P hemorrhoids. PMID:28658138

Complexation of the actinides (III, IV and V) with organic acids

International Nuclear Information System (INIS)

Leguay, S.

2012-01-01

A thorough knowledge of the chemical properties of actinides is now required in a wide variety of fields: extraction processes involved in spent fuel reprocessing, groundwater in the vicinity of radioactive waste packages, environmental and biological media in the case of accidental release of radionuclides. In this context, the present work has been focused on the complexation of Am(III), Cm(III), Cf(III), Pu(IV) and Pa(V) with organic ligands: DTPA, NTA and citric acid. The complexation of pentavalent protactinium with citric and nitrilotriacetic acids was studied using liquid-liquid extraction with the element at tracer scale (C Pa ≤ 10 -10 M). The order and the mean charge of each complex were determined from the analysis of the systematic variations of the distribution coefficient of Pa(V) as function of ligand and proton concentration. Then, the apparent formation constants related of the so-identified complexes were calculated. The complexation of trivalent actinides with DTPA was studied by fluorescence spectroscopy (TRLFS) and capillary electrophoresis (CE-ICP-MS). The coexistence of the mono-protonated and non-protonated complexes (AnHDTPA - and AnDTPA 2- ) in acidic media (1.5 ≤ pH ≤ 3.5) was shown unambiguously. Literature data have been reinterpreted by taking into account both complexes and a consistent set of formation constants of An(III)-DTPA has been obtained. The experimental study was completed by theoretical calculations (DFT) on Cm-DTPA system. The coordination geometry of Cm in CmDTPA 2- and CmHDTPA - including water molecules in the first coordination sphere has been determined as well as interatomic distances. Finally, a study on the complexation of Pu(IV) with DTPA was initiated in order to more closely mimic physiological conditions. A three-step approach was proposed to avoid plutonium hydrolysis: i/ complexation of Pu(IV) with (NTA) in order to protect Pu(IV) from hydrolysis (at low pH) ii/ increase of pH toward neutral conditions

Coulometric microdetermination of organic compounds with manganese(III) and cerium(IV)

International Nuclear Information System (INIS)

Chateau-Gosselin, M.; Patriarche, G.J.

1977-01-01

The oxidation of compounds such as hydroquinon, p-aminophenol, paracetamol and phenacetin was performed using cerium(IV) and manganese(III) coulometrically electrogenerated. Quantitative results obtained are excellent even at the microscale level. (author)

Grade III or Grade IV Hypertensive Retinopathy with Severely Elevated Blood Pressure

Directory of Open Access Journals (Sweden)

Amanda D Henderson

2012-12-01

Full Text Available Introduction: Hypertensive retinopathy describes a spectrum of retinal changes in patients with elevated blood pressure (BP. It is unknown why some patients are more likely to develop acute ocular end-organ damage than others with similar BP. We examined risk factors for grade III/IV hypertensive retinopathy among patients with hypertensive urgency in the emergency department (ED and compared healthcare utilization and mortality between patients with and without grade III/IV hypertensive retinopathy.Methods: A preplanned subanalysis of patients who presented to a university hospital ED with diastolic BP > 120 mmHg and who enrolled in the Fundus Photography versus Ophthalmoscopy Trial Outcomes in the ED study was performed. Bilateral nonmydriatic ocular fundus photographs, vital signs, and demographics were obtained at presentation. Past medical history, laboratory values, healthcare utilization, and mortality were ascertained from medical record review at least 8 months after initial ED visit.Results: Twenty-one patients with diastolic BP > 120 mmHg, 7 of whom (33% had grade III/IV hypertensive retinopathy, were included. Patients with retinopathy were significantly younger than those without (median 33 vs 50 years, P = 0.02. Mean arterial pressure (165 vs 163 mmHg was essentially equal in the 2 groups. Patients with retinopathy had substantially increased but nonsignificant rates of ED revisit (57% vs 29%, P = 0.35 and hospital admission after ED discharge (43% vs 14%, P = 0.28. One of the patients with retinopathy died, but none without.Conclusion: Younger patients may be at higher risk for grade III/IV hypertensive retinopathy among patients with hypertensive urgency. Chronic compensatory mechanisms may have not yet developed in these younger patients. Alternatively, older patients with retinopathy may be underrepresented secondary to increased mortality among these patients at a younger age (survivorship bias. Further research is needed to

Comparison of outcomes in patients with stage III versus limited stage IV non-small cell lung cancer

International Nuclear Information System (INIS)

Cheruvu, Praveena; Metcalfe, Su K; Metcalfe, Justin; Chen, Yuhchyau; Okunieff, Paul; Milano, Michael T

2011-01-01

Standard therapy for metastatic non small cell lung cancer (NSCLC) includes palliative systemic chemotherapy and/or radiotherapy. Recent studies of patients with limited metastases treated with curative-intent stereotactic body radiation therapy (SBRT) have shown encouraging survival. We hypothesized that patients treated with SBRT for limited metastases have comparable outcomes with those treated with curative-intent radiation for Stage III NSCLC. We retrospectively reviewed the records of NSCLC patients treated with curative-intent radiotherapy at the University of Rochester from 2000-2008. We identified 3 groups of patients with NSCLC: stage III, stage IV, and recurrent stage IV (initial stage I-II). All stage IV NSCLC patients treated with SBRT had ≤ 8 lesions. Of 146 patients, 88% had KPS ≥ 80%, 30% had > 5% weight loss, and 95% were smokers. The 5-year OS from date of NSCLC diagnosis for stage III, initial stage IV and recurrent stage IV was 7%, 14%, and 27% respectively. The 5-year OS from date of metastatic diagnosis was significantly (p < 0.00001) superior among those with limited metastases (≤ 8 lesions) versus stage III patients who developed extensive metastases not amenable to SBRT (14% vs. 0%). Stage IV NSCLC is a heterogeneous patient population, with a selected cohort apparently faring better than Stage III patients. Though patients with limited metastases are favorably selected by virtue of more indolent disease and/or less bulky disease burden, perhaps staging these patients differently is appropriate for prognostic and treatment characterization. Aggressive local therapy may be indicated in these patients, though prospective clinical studies are needed

Hydration structures of U(III) and U(IV) ions from ab initio molecular dynamics simulations

International Nuclear Information System (INIS)

Leung, Kevin; Nenoff, Tina M.

2012-01-01

We apply DFT+U-based ab initio molecular dynamics simulations to study the hydration structures of U(III) and U(IV) ions, pertinent to redox reactions associated with uranium salts in aqueous media. U(III) is predicted to be coordinated to 8 water molecules, while U(IV) has a hydration number between 7 and 8. At least one of the innershell water molecules of the hydrated U(IV) complex becomes spontaneously deprotonated. As a result, the U(IV)–O pair correlation function exhibits a satellite peak at 2.15 Å associated with the shorter U(IV)–(OH − ) bond. This feature is not accounted for in analysis of extended x-ray absorption fine structure and x-ray adsorption near edge structure measurements, which yield higher estimates of U(IV) hydration numbers. This suggests that it may be useful to include the effect of possible hydrolysis in future interpretation of experiments, especially when the experimental pH is close to the reported hydrolysis equilibrium constant value.

Non-LTE equivalent widths for Si II, III and IV

International Nuclear Information System (INIS)

Becker, S.R.; Butler, K.

1990-01-01

Equivalent widths for a set of Si II, III and IV lines reliable for the determination of temperatures in the B star parameter range are given. They are calculated on a fine grid of LTE line blanketed model atmospheres and lie in the wavelength region from 4070 A to 5070 A

Determination of disulfide bridges of two spider toxins: hainantoxin-III and hainantoxin-IV

Directory of Open Access Journals (Sweden)

W Wang

2009-01-01

Full Text Available Peptide toxins are usually highly bridged proteins with multipairs of intrachain disulfide bonds. Analysis of disulfide connectivity is an important facet of protein structure determination. In this paper, we successfully assigned the disulfide linkage of two novel peptide toxins, called HNTX-III and HNTX-IV, isolated from the venom of Ornithoctonus hainana spider. Both peptides are useful inhibitors of TTX-sensitive voltage-gated sodium channels and are composed of six cysteine residues that form three disulfide bonds, respectively. Firstly, the peptides were partially reduced by tris(2-carboxyethyl-phosphine (TCEP in 0.1 M citrate buffer containing 6 M guanidine-HCl at 40° C for ten minutes. Subsequently, the partially reduced intermediates containing free thiols were separated by reversed-phase high-performance liquid chromatography (RP-HPLC and alkylated by rapid carboxamidomethylation. Then, the disulfide bonds of the intermediates were analyzed by Edman degradation. By using the strategy above, disulfide linkages of HNTX-III and HNTX-IV were determined as I-IV, II-V and III-VI pattern. In addition, this study also showed that this method may have a great potential for determining the disulfide bonds of spider peptide toxins.

High response rates following paclitaxel/5-FU and simultaneous radiotherapy in advanced head and neck carcinoma; Hohe Remissionsraten unter simultaner Radio- und Chemotherapie mit Paclitaxel/5-FU in der Behandlung fortgeschrittener Kopf-Hals-Tumoren

Energy Technology Data Exchange (ETDEWEB)

Schroeder, M.; Westerhausen, M. [St.-Johannes-Hospital, Duisburg (Germany). Medizinische Klinik II; Makoski, H.B. [Staedtische Kliniken, Duisburg (Germany). Radioonkologie; Sesterhenn, K. [St. Anna-Krankenhaus, Duisburg (Germany). HNO-Klinik; Schroeder, R. [Bristol Myers Squibb, Muenchen (Germany). Dept. of Oncology

1997-11-01

applizierter Strahlentherapie. Mit dieser multimodalen Therapiestrategie einschliesslich einer interponierten chirurgischen Massnahme haben wir fuer Patienten mit einem Stadium III/IV Fuenf-Jahres-Ueberlebenszeiten von 60% berichtet. Paclitaxel, ein neues Chemotherapeutikum, erreichte im Rahmen einer ECOG-Studie in Monotherapieform eine Ansprechrate von 40%. Patienten und Methoden: Zwischen 1994 und 1997 wurden 30 Patienten mit vorbestehenden Kontraindikationen gegen Cisplatin mit Paclitaxel/5-FU und gleichzeitiger Bestrahlung in einem neoadjuvanten und postoperativ adjuvanten Therapieschema behandelt. Die Patienten erhielten Paclitaxel 175 mg/m{sup 2} an Tag 1+29 und 5-FU als 120stuendige Dauerinfusion in der Dosis 1000 mg/m{sup 2}/d. Die Bestrahlungsdosis betrug praeoperativ 40 und postoperativ 30 Gy. Alle 30 bisher so behandelten Patienten erreichten eine komplette Remission (histologisch operativ gesichert) nach Abschluss des gesamten Behandlungskonzepts. Ergebnisse: Bis heute leben 23/30 Patienten rezidiv/bzw. tumorfrei. In einem Nachbeobachtungszeitraum zwischen 6 und 34 Monaten entwickelten 4 Patienten eine zweite Neoplasie im Bereich der Rauch-Schluckstrasse (Bronchial-Ca., Oesophagus-Ca.), 3 Patienten erlitten ein lokales Rezidiv. Die Gesamttoxizitaet war moderat (Haematotoxizitaet, Neurotoxizitaet) und gut managebar mit supportiven Massnahmen (z.B. PEG-Sonde). Schlussfolgerung: Unsere praeliminaren Ergebnisse der kombinierten Behandlung der fortgeschrittenenen Kopf-Hals-Tumore mit Taxol/5-FU und Strahlentherapie und Operation sind sehr vielversprechend und identisch mit den Behandlungsergebnissen mit Cisplatin/5-FU. (orig.)

Electrochemistry and Spectroelectrochemistry of the Pu (III/IV) and (IV/VI) Couples in Nitric Acid Systems

Energy Technology Data Exchange (ETDEWEB)

Lines, Amanda M. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Adami, Susan R. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Casella, Amanda J. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Sinkov, Sergey I. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Lumetta, Gregg J. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352; Bryan, Samuel A. [Nuclear Chemistry and Engineering, Pacific Northwest National Laboratory, Richland WA 99352

2017-09-20

The solution chemistry of Pu in nitric acid is explored via electrochemistry and spectroelectrochemistry. By utilizing and comparing these techniques, an improved understanding of Pu behavior and its dependence on nitric acid concentration can be achieved. Here the Pu (III/IV) couple is characterized using cyclic voltammetry, square wave voltammetry, and a spectroelectrochemical Nernst step. Results indicate the formal reduction potential of the couple shifts negative with increasing acid concentration and reversible electrochemistry is no longer attainable above 6 M HNO3. Spectroelectrochemistry is also used to explore the irreversible oxidation of Pu(IV) to Pu(VI) and shine light on the mechanism and acid dependence of the redox reaction.

(NH4)[V1-xIIIVxIV(AsO4)F1-xOx]: A new mixed valence vanadium(III,IV) fluoro-arsenate with ferromagnetic interactions and electronic conductivity

International Nuclear Information System (INIS)

Berrocal, Teresa; Mesa, Jose L.; Pizarro, Jose L.; Bazan, Begona; Ruiz de Larramendi, Idoia; Arriortua, Maria I.; Rojo, Teofilo

2009-01-01

A new mixed valence vanadium(III,IV) fluoro-arsenate compound, with formula (NH 4 )[V 1-x III V x IV (AsO 4 )F 1-x O x ] and KTP structure-type, has been synthesized by mild hydrothermal techniques. The crystal structure has been solved from single crystal X-ray diffraction data in the Pna2 1 orthorhombic space group. The unit-cell parameters are a=13.196(2) A, b=6.628(1) A and c=10.7379(7) A with Z=8. The final R factors were R1=0.0438 and wR2=0.0943 [all data]. The crystal structure consists of a three-dimensional framework formed by (V III,IV O 4 F 2 ) octahedra and (AsO 4 ) 3- tetrahedra arsenate oxoanions. The vanadium(III,IV) cations, from the (V III,IV O 4 F 2 ) octahedra, are linked through the fluorine atoms giving rise to zigzag chains. The ammonium cations are located in the cavities of the structure compensating the anionic charge of the [V 1-x III V x IV (AsO 4 )F 1-x O x ] - inorganic skeleton. The thermal stability limit of the phase is 345 deg. C, around to this temperature the ammonium cation and fluoride anion are lost. The IR spectrum shows the characteristic bands of the (NH 4 ) + and (AsO 4 ) 3- ions. Magnetic measurements indicate the existence of weak ferromagnetic interactions. Electronic conductivity, via a hopping mechanism, occurs with an activation energy of 0.66 eV. - Graphical abstract: Polyhedral view of the crystal structure of (NH 4 )[V III 1-x V IV x (AsO 4 )F 1-x O x

MRI of the hyaline knee joint cartilage. Animal experimental and clinical studies; MRT des hyalinen Kniegelenkknorpels. Tierexperimentelle und klinische Untersuchungen

Energy Technology Data Exchange (ETDEWEB)

Adam, G. [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Prescher, A. [Technische Hochschule Aachen (Germany). Inst. fuer Anatomie; Nolte-Ernsting, C. [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Buehne, M. [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik; Scherer, K. [Technische Hochschule Aachen (Germany). Inst. fuer Versuchstierkunde; Kuepper, W. [Technische Hochschule Aachen (Germany). Inst. fuer Versuchstierkunde; Guenther, R.W. [Technische Hochschule Aachen (Germany). Klinik fuer Radiologische Diagnostik

1994-02-01

The value of MR imaging for the detection of hyaline cartilage lesions using 2-D spin-echo and 3-D gradient-echo imaging was evaluated in an animal experiment in 10 dogs and in a clinical study in 30 patients. MR imaging findings were compared with histopathological and arthroscopy findings, respectively. Using MRI neither grade I nor grade II hyaline cartilage lesions were detectable. In the animal experiments 77% of grade III lesions and all the grade IV lesions were seen. However, in the clinical study only about the half of grade III and IV lesions were detected. 3-D gradient-echo MR imaging was superior to 2-D spin-echo imaging (p<0.001), while 3-D FLASH and 3-D FISP did not differ significantly in the detection rate (p<0.34). 3-D gradient-echo MR imaging seems to be the best method for the delineation of high grade cartilage lesions. However, early stages of cartilage degeneration are invisible even with this imaging modality. (orig.) [Deutsch] Die Wertigkeit der MRT in der Erfassung von Knorpellaesionen mit 2-D-Spin-Echo- und 3-D-Grafienten-Echo-Sequenzen wurde in einer tierexperimentellen Untersuchung an 10 Hunden sowie in einer klinischen Studie an 30 Patienten ueberprueft. Die kernspintomographischen Ergebnisse wurden mit dem pathologisch-anatomischen Befund bzw. der Arthroskopie verglichen. MR-tomographisch konnten weder Grad-I- noch Grad-II-Knorpellaesionen erfasst werden. Die Erkennbarkeitsrate der Grad-III- und -IV-Laesionen lag fuer die tierexperimentellen Untersuchungen bei 77 bzw. 100%, waehrend klinisch nur etwa 50% dieser Veraenderungen erkannt werden konnten. Dabei waren die 3-D-Gradienten-Echo-Sequenzen den 2-D-Spin-Echo-Sequenzen signifikant ueberlegen (p<0,001), waehrend sich die 3-D-Gradienten-Echo-Sequenzen FISP und FLASH nicht voneinander unterschieden (p<0,34). Derzeit muessen die 3-D-Gradienten-Echo-Sequenzen als die beste Methode zur Erfassung hoehergradiger Knorpellaesionen angesehen werden. Fruehe Stadien der Knorpelschaedigung sind

Multiscale structural characterizations of mixed U(iv)-An(iii) oxalates (An(iii) = Pu or Am) combining XAS and XRD measurements.

Science.gov (United States)

Arab-Chapelet, B; Martin, P M; Costenoble, S; Delahaye, T; Scheinost, A C; Grandjean, S; Abraham, F

2016-04-28

Mixed actinide(III,IV) oxalates of the general formula M2.2UAn(C2O4)5·nH2O (An = Pu or Am and M = H3O(+) and N2H5(+)) have been quantitatively precipitated by oxalic precipitation in nitric acid medium (yield >99%). Thorough multiscale structural characterization using XRD and XAS measurements confirmed the existence of mixed actinide oxalate solid solutions. The XANES analysis confirmed that the oxidation states of the metallic cations, tetravalent for uranium and trivalent for plutonium and americium, are maintained during the precipitation step. EXAFS measurements show that the local environments around U(+IV), Pu(+III) and Am(+III) are comparable, and the actinides are surrounded by ten oxygen atoms from five bidentate oxalate anions. The mean metal-oxygen distances obtained by XAS measurements are in agreement with those calculated from XRD lattice parameters.

Docetaxel, cisplatin and 5-fluorouracil induction chemotherapy followed by chemoradiotherapy or chemoradiotherapy alone in stage III-IV unresectable head and neck cancer. Results of a randomized phase II study

Energy Technology Data Exchange (ETDEWEB)

Takacsi-Nagy, Zoltan; Polgar, Csaba; Major, Tibor; Fodor, Janos [National Institute of Oncology, Center of Radiotherapy, Budapest (Hungary); Hitre, Erika [National Institute of Oncology, Department of Chemotherapy and Clinical Pharmacology, Budapest (Hungary); Remenar, Eva; Kasler, Miklos [National Institute of Oncology, Department of Head and Neck and Maxillofacial Surgery, Budapest (Hungary); Oberna, Ferenc [Bacs-Kiskun County Hospital, Department of Oral, Maxillofacial and Head and Neck Surgery, Kecskemet (Hungary); Goedeny, Maria [National Institute of Oncology, Department of Radiology, Budapest (Hungary)

2015-08-15

adequate patient selection if ICT is considered. (orig.) [German] Simultane Chemoradiotherapie (CRT) ist eine Standardtherapie beim fortgeschrittenen Plattenepithelkarzinom im Kopf-Hals-Bereich. In dieser randomisierten Phase-II-Studie wurden die Wirksamkeit und Toxizitaet einer Induktionschemotherapie (ICT) mit Docetaxel, Cisplatin und 5-Fluorouracil gefolgt von simultaner CRT mit der CRT allein bei Patienten mit lokal fortgeschrittenen, irresektablen Kopf-Hals-Tumoren verglichen. Zwischen Januar 2007 und Juni 2009 wurden 66 Patienten mit fortgeschrittenem (Stadium III oder IV), inoperablem Plattenepithelkarzinom im Kopf-Hals-Bereich (Mundhoehle, Oropharynx, Hypopharynx, Larynx) nach dem Zufallsprinzip in 2 Gruppen eingeteilt. Die eine Gruppe erhielt 2 Zyklen der Docetaxel-, Cisplatin- und 5-Fluorouracil-ICT gefolgt von CRT mit 3 Zyklen Cisplatin, die andere Gruppe erhielt nur CRT. Ansprechrate, lokale Tumorkontrolle (LTC), lokoregionale Tumorkontrolle (LRTC), Gesamtueberleben (OS), progressionsfreies Ueberleben (PFS) und toxischer Effekt wurden verglichen. Drei Patienten der Gruppe mit ICT + CRT erschienen bei der ersten Behandlung nicht, so dass insgesamt 63 Patienten in der Studie ausgewertet wurden (30 in der Gruppe ICT + CRT, 33 in der CRT-Gruppe). Drei Patienten starben an febriler Neutropenie nach ICT. Die mediane Nachbeobachtungszeit der ueberlebenden Patienten betrug 63 Monate (Spanne 53-82 Monate). Die Rate des radiologischen vollstaendigen Ansprechens war 63 % nach ICT + CRT vs. 70 % nach CRT allein. Es gab keinen signifikanten Unterschied in der 3-Jahres-Rate bei LTC (56 vs. 57 %), LRTC (42 vs. 50 %), OS (43 vs. 55 %) und PFS (41 vs. 50 %) zwischen der Gruppe mit ICT + CRT und den mit CRT behandelten Patienten. Die Rate von Neutropenie mit einem Grad 3-4 lag in der Gruppe mit ICT + CRT deutlich hoeher als in der CRT-Gruppe (37 und 12 %; p = 0,024). Spaete Toxizitaet (Grad-2- und Grad-3-Xerostomie) ereignete sich in der Gruppe mit ICT + CRT und in der CRT

Identification of novel mammalian hosts and Brazilian biome geographic distribution of Trypanosoma cruzi TcIII and TcIV.

Science.gov (United States)

Barros, Juliana Helena S; Xavier, Samanta Cristina C; Bilac, Daniele; Lima, Valdirene Santos; Dario, Maria Augusta; Jansen, Ana Maria

2017-08-01

Trypanosoma cruzi is a parasitic protozoan responsible for Chagas disease. Seven different Discrete Typing Units (DTUs) of T. cruzi are currently identified in nature: TcI-TcVI, and TcBat whose distribution patterns in nature, hosts/reservoirs and eco-epidemiological importance are still little known. Here, we present novel data on the geographic distribution and diversity of mammalian hosts and vectors of T. cruzi DTUs TcIII and TcIV. In this study, we analyzed 61 T. cruzi isolates obtained from 18 species of mammals (five orders) and two Hemiptera genera. Samples were collected from five Brazilian biomes (Pantanal, Caatinga, Cerrado, Atlantic Rainforest, and Amazon) previously characterized as Z3 or mixed infection (TcI-Z3) by mini-exon gene PCR. To identify TcIII and TcIV genotypes, we applied restriction fragment length polymorphism analysis to the PCR-amplified histone 3 gene. DTUs TcIII and TcIV were identified in single and mixed infections from wide dispersion throughout five Brazilian biomes studied, with TcIV being the most common. Pantanal was the biome that displayed the largest number of samples characterized as TcIII and TcIV in single and mixed infections, followed by Atlantic Rainforest and Amazon. Species from the Didelphimorphia order displayed the highest frequency of infection and were found in all five biomes. We report, for the first time, the infection of a species of the Artiodactyla order by DTU TcIII. In addition, we describe new host species: five mammals (marsupials and rodents) and two genera of Hemiptera. Our data indicate that DTUs TcIII and TcIV are more widespread and infect a larger number of mammalian species than previously thought. In addition, they are transmitted in restricted foci and cycles, but in different microhabitats and areas with distinct ecological profiles. Finally, we show that DTUs TcIII and TcIV do not present any specific association with biomes or host species. Copyright © 2017. Published by Elsevier B.V.

Amine and Titanium (IV Chloride, Boron (III Chloride or Zirconium (IV Chloride-Promoted Baylis-Hillman Reactions

Directory of Open Access Journals (Sweden)

Shi-Cong Cui

2001-10-01

Full Text Available The Baylis-Hillman reactions of various aryl aldehydes with methyl vinyl ketone at temperatures below -20oC using Lewis acids such as titanium (IV chloride, boron (III chloride or zirconium (IV chloride in the presence of a catalytic amount of selected amines used as a Lewis bases afford the chlorinated compounds 1 as the major product in very high yields. Acrylonitrile can also undergo the same reaction to give the corresponding chlorinated product in moderate yield. A plausible reaction mechanism is proposed. However, if the reaction was carried out at room temperature (ca. 20oC, then the Z-configuration of the elimination product 3, derived from 1, was formed as the major product.

Cranial nerves III, IV and VI

International Nuclear Information System (INIS)

Laine, I.J.; Smoker, W.R.; Kuta, A.J.; Felton, W.L.

1991-01-01

Because of advances in CT and MR imaging, accurate identification and evaluation of cranial nerve lesions is now possible. Cranial nerves III, IV, and VI, providing motor and sensory control of the eye, can be evaluated as a unit. In this paper, the authors present an overview of the anatomy and pathology of these cranial nerves. We first illustrate their normal anatomic pathways from the brain stem to the orbit. This is followed by clinical examples of patients with a variety of isolated and complex palsies of these three cranial nerves. This is accomplished by inclusion of ocular photographs, correlative imaging studies, and the use of diagrams. Knowledge of the gross and imaging anatomy and the ophthalmologic manifestations of pathology affecting these three cranial nerves permits a tailored approach to their evaluation

Liquid-liquid extraction/separation of platinum(IV) and rhodium(III) from acidic chloride solutions using tri-iso-octylamine

Energy Technology Data Exchange (ETDEWEB)

Lee, Jin-Young, E-mail: jinlee@kigam.re.kr [Metals Recovery Department, Minerals Resources Research Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), 92 Gahangno, Yuesong-gu, Daejeon 305-350 (Korea, Republic of); Rajesh Kumar, J., E-mail: rajeshkumarphd@rediffmail.com [Metals Recovery Department, Minerals Resources Research Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), 92 Gahangno, Yuesong-gu, Daejeon 305-350 (Korea, Republic of); Kim, Joon-Soo; Park, Hyung-Kyu; Yoon, Ho-Sung [Metals Recovery Department, Minerals Resources Research Division, Korea Institute of Geoscience and Mineral Resources (KIGAM), 92 Gahangno, Yuesong-gu, Daejeon 305-350 (Korea, Republic of)

2009-08-30

Liquid-liquid extraction/separation of platinum(IV) and rhodium(III) from acidic chloride solutions was carried out using tri-iso-octylamine (Alamine 308) as an extractant diluted in kerosene. The percentage extraction of platinum(IV) and rhodium(III) increased with increase in acid concentration up to 8 mol L{sup -1}. However, at 10 mol L{sup -1} HCl concentration, the extraction behavior was reversed, indicating the solvation type mechanism during extraction. The quantitative extraction of {approx}98% platinum(IV) and 36% rhodium(III) was achieved with 0.01 mol L{sup -1} Alamine 308. The highest separation factor (S.F. = 184.7) of platinum(IV) and rhodium(III) was achieved with 0.01 mol L{sup -1} Alamine 308 at 1.0 mol L{sup -1} of hydrochloric acid concentration. Alkaline metal salts like sodium chloride, sodium nitrate, sodium thiocyanate, lithium chloride, lithium nitrate, potassium chloride and potassium thiocyanate used for the salting-out effect. LiCl proved as best salt for the extraction of platinum(IV). Temperature effect demonstrates that the extraction process is exothermic. Hydrochloric acid and thiourea mixture proved to be better stripping reagents when compared with other mineral acids and bases.

Hyperfractionated radiotherapy and simultaneous cisplatin for stage-III and -IV carcinomas of the head and neck. Long-term results including functional outcome

Energy Technology Data Exchange (ETDEWEB)

Huguenin, P.; Glanzmann, C.; Taussky, D.; Luetolf, U.M. [Univ. Hospital Zurich (Switzerland). Radiation Oncology Dept.; Schmid, S.; Moe, K. [Univ. Hospital Zurich (Switzerland). Dept. of Head and Neck Surgery

1998-08-01

highly efficient in controlling moderately advanced to advanced cancers of the head and neck. Second primary tumors are the main cause of death after 3 years and were observed outside of the irradiated area, most frequently in the lung. Even after RT of large volumes to a high dose, salvage surgery can be successfully performed in individual cases. Self-reported quality of life of surviving patients is good, despite xerostomy-associated nutritional difficulties. (orig.) [Deutsch] Ziel: Analyse der Ueberlebensrate, des krankheitsspezifischen Ueberlebens, des Rezidivmusters, der Spaettoxizitaet sowie der subjektiven Lebensqualitaet nach hyperfraktionierter Radiotherapie (RT) und gleichzeitiger Cisplatin-Chemotherapie (CDDP) bei Patienten mit mindestens zwei Jahren Beobachtungszeit im Rahmen einer prospektiven Phase-II-Studie. Patienten und Methode: Im Rahmen einer Pilotstudie (1988 bis 1994) wurden 64 Patienten (medianes Alter 55,5 Jahre) mit Stadium III oder IV kombiniert behandelt: RT 1,2 Gy zweimal taeglich bis 74,4 Gy, CDDP 20 mg/m{sup 2} taeglich an den Tagen 1 bis 5 der ersten und fuenften Woche. Die Ueberlebenskurven sowie die Toxizitaet wurden aktuariell berechnet. Die mediane Beobachtungszeit war 3,3 Jahre fuer alle respektive 5,2 Jahre fuer die ueberlebenden Patienten. Zur Einschaetzung der Lebensqualitaet wurden 23 tumorfrei ueberlebende Patienten angefragt, den EORTC-QLQ-C30-Fragebogen sowie das ergaenzende Modul fuer Kopf-Hals-Tumoren H and N35 auszufuellen. Ergebnisse: Das Gesamtueberleben betrug nach fuenf Jahren 37%, waehrend das krankheitsspezifische Ueberleben mit 59% deutlich hoeher lag. 23 Patienten sind am Tumor verstorben. Zweittumoren, hauptsaechlich Lungenkarzinome (n=8), wurden bei 13 Patienten registriert und waren die hauptsaechliche Todesursache nach ueber drei Jahren. Die lokale Tumorkontrolle ohne zusaetzliche Chirurgie betrug 74% nach fuenf Jahren und war fuer alle Lokalisationen und Stadien gleich; die lokoregionaere Tumorkontrollrate lag

Redox reactions of Pu(IV) and Pu(III) in the presence of acetohydroxamic acid in HNO(3) solutions.

Science.gov (United States)

Tkac, Peter; Precek, Martin; Paulenova, Alena

2009-12-21

The reduction of Pu(IV) in the presence of acetohydroxamic acid (HAHA) was monitored by vis-NIR spectroscopy. All experiments were performed under low HAHA/Pu(IV) ratios, where only the Pu(IV)-monoacetohydroxamate complex and Pu uncomplexed with HAHA were present in relevant concentrations. Time dependent concentrations of all absorbing species were resolved using molar extinction coefficients for Pu(IV), Pu(III), and the Pu(AHA)(3+) complex by deconvolution of spectra. From fitting of the experimental data by rate equations integrated by a numeric method three reactions were proposed to describe a mechanism responsible for the reduction and oxidation of plutonium in the presence of HAHA and HNO(3). Decomposition of Pu(AHA)(3+) follows a second order reaction mechanism with respect to its own concentration and leads to the formation of Pu(III). At low HAHA concentrations, a two-electron reduction of uncomplexed Pu(IV) with HAHA also occurs. Formed Pu(III) is unstable and slowly reoxidizes back to Pu(IV), which, at the point when all HAHA is decomposed, can be catalyzed by the presence of nitrous acid.

JGOFS IV - a long-time study of the variability of the flow of particles in the North-Atlantic Ocean. Quantification of the formation, transformation and sedimentation of biogenic particles. Final report; JGOFS IV - Langzeitstudie zur Variabilitaet des Partikelflusses im Nordatlantik. Quantifizierung der Bildung, Umsetzung und Sedimentation biogener Partikel. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Koeve, W.; Wanniek, J.; Fehner, U.; Zeitzschel, B.

2000-07-01

The project investigated central processes of the carbon cycle, and especially the carbon cycle balance in the North Atlantic Ocean. During the field phase (JGOFS I-III), two complementary programme components were carried out: Pelagial programme: SEasonally resolved studies of particle formation, modification and transport processes in the epipelagial; In-depth programme: Regional studies on the volume and composition of biogenic particles exported from the ocean in the mixed conditions of the winter season. (WML export). [German] Ziel der Arbeiten ist es, das Verstaendnis zentraler Prozesse des Kohlenstoffkreislaufes im Nordostatlantik zu verbessern und insbesondere zur Bilanzierung des Kohlenstoffkreislaufes im Nordostatlantik beizutragen. Waehrend der Feldphase (JGOFS I-III) wurden hierzu zwei komplementaere Programmkomponenten durchgefuehrt: - Pelagialprogramm: Saisonal aufloesende Untersuchungen zu Prozessen der Partikelbildung, Modifikation und Transport im Epipelagial. (Prozessstudien, Transekte und Modellarbeiten) - Verankerungsprogramm: Regionale Untersuchungen zum Umfang und zur Zusammensetzung des Exportes biogener Partikel aus der winterlich durchmischten Schicht des Ozeans (WML-Export). (orig.)

Cost analysis of surgically treated pressure sores stage III and IV.

NARCIS (Netherlands)

Filius, A.; Damen, T.H.; Schuijer-Maaskant, K.P.; Polinder, S.; Hovius, S.E.R.; Walbeehm, E.T.

2013-01-01

Health-care costs associated with pressure sores are significant and their financial burden is likely to increase even further. The aim of this study was to analyse the direct medical costs of hospital care for surgical treatment of pressure sores stage III and IV. We performed a retrospective chart

Classification of pediatric functional gastrointestinal disorders related to abdominal pain using Rome III vs. Rome IV criterions.

Science.gov (United States)

Edwards, Trent; Friesen, Craig; Schurman, Jennifer V

2018-03-17

The primary purpose of this study was to compare Rome III and IV evaluation criteria for irritable bowel syndrome (IBS), functional dyspepsia (FD), and an overlap syndrome consisting of both IBS and FD by assessing the frequency of each diagnosis in a population of children with chronic abdominal pain. Frequencies of Rome IV FD subtypes of postprandial distress syndrome (PDS) and epigastric pain syndrome (EPS) were determined and FD/IBS overlap symptom associations were also assessed. We conducted a cross-sectional retrospective chart review of 106 pediatric patients who had completed standardized medical histories as part of their evaluation for chronic abdominal pain. The patients ranged from eight to 17 years of age and reported having abdominal pain at least weekly for 8 weeks. Patients whose evaluation revealed gastrointestinal disease were excluded. The patients' diagnoses were determined by a single pediatric gastroenterologist utilizing the specific criteria for Rome III and IV, respectively. Patients were significantly more likely to be diagnosed with FD (84.9% vs. 52.8%), IBS (69.8% vs. 34%), and FD/IBS overlap (58.5% vs. 17.9%) by Rome IV criteria, as compared to Rome III criteria. With regard to Rome IV FD subtypes, 81.1% fulfilled criteria for PDS, 11.1% fulfilled criteria for EPS, 6.7% fulfilled criteria for both, and 1.1% did not fulfill criteria for either. Finally, we found an increased frequency of diarrhea and pain with eating in the overlap group compared to the non-overlap group of Rome III, while only an increased frequency of diarrhea was found in the overlap group compared to the non-overlap group of Rome IV. Our data demonstrate that utilizing Rome IV criteria, as compared to Rome III, results in an increase in the diagnosis of FD, a two-fold increase in the diagnosis of IBS, and a three-fold increase in the diagnosis of FD/IBS overlap. Rome IV criteria appears to result in greater heterogeneity within diagnostic categories. It is important

Zwitterion-functionalized polymer microspheres as a sorbent for solid phase extraction of trace levels of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) prior to their determination by ICP-MS.

Science.gov (United States)

Jia, Xiaoyu; Gong, Dirong; Zhao, Junyi; Ren, Hongyun; Wang, Jiani; Zhang, Xian

2018-03-19

This paper describes the preparation of zwitterion-functionalized polymer microspheres (ZPMs) and their application to simultaneous enrichment of V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) from environmental water samples. The ZPMs were prepared by emulsion copolymerization of ethyl methacrylate, 2-diethylaminoethyl methacrylate and triethylene glycol dimethyl acrylate followed by modification with 1,3-propanesultone. The components were analyzed by elemental analyses as well as Fourier transform infrared spectroscopy, and the structures were characterized by scanning electron microscopy and transmission electron microscopy. The ZPMs were packed into a mini-column for on-line solid-phase extraction (SPE) of the above metal ions. Following extraction with 40 mM NH 4 NO 3 and 0.5 M HNO 3 solution, the ions were quantified by ICP-MS. Under the optimized conditions, the enrichment factors (from a 40 mL sample) are up to 60 for the ions V(V), As(III), Sb(III) and Hg(II), and 55 for Cr(III) and Sn(IV). The detection limits are 1.2, 3.4, 1.0, 3.7, 2.1 and 1.6 ng L -1 for V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II), respectively, and the relative standard deviations (RSDs) are below 5.2%. The feasibility and accuracy of the method were validated by successfully analyzing six certified reference materials as well as lake, well and river waters. Graphical abstract Zwitterion-functionalized polymer microspheres (ZPMs) were prepared and packed into a mini-column for on-line solid-phase extraction (SPE) via pump 1. Then V(V), Cr(III), As(III), Sn(IV), Sb(III) and Hg(II) ions in environmental waters were eluted and submitted to ICP-MS via pump 2.

Contributions to ecosystem research and environmental education III; Beitraege zur Oekosystemforschung und Umwelterziehung III

Energy Technology Data Exchange (ETDEWEB)

Erdmann, K H [ed.; Nauber, J [ed.

1996-09-01

The publication comprises the following chapters: Contributions to the implementation of findings in policy and administration; Contributions to biosphere reservations; Contributions to ecosystems research; Contributions to environmental education. The first chapter discusses environmental protection from the political point of view, while the second chapter describes biosphere reservations world-wide as well as their protection, conservation and development. (SR) [Deutsch] Die vorliegende Veroeffentlichung teilt sich in folgende Kapitel auf: Beitraege zur Umsetzung von Erkenntnissen in Politik und Verwaltung, Beitraege zu Biosphaerenreservaten, Beitraege zur Oekosystemforschung sowie Beitraege zur Umwelterziehung. Im ersten Kapitel wird der Umweltschutz von der politischen Seite aus beleuchtet. Das zweite Kapitel beschreibt verschiedene Biosphaerenreservate in der ganzen Welt und deren Schutz, Pflege und Entwicklung. Das dritte Kapitel beinhaltet Beitraege zur oekologischen Forschung. Abschliessend werden im letzten Kapitel psychologische Aspekte der Umwelterziehung dargestellt. (SR)

Biologically relevant mono- and di-nuclear manganese II/III/IV complexes of mononegative pentadentate ligands

DEFF Research Database (Denmark)

Baffert, Carole; Collomb, Marie-Nöelle; Deronzier, Alain

2003-01-01

were characterised by UV-visible spectroscopy, ESI mass spectrometry and cyclic voltammetry. In addition, III-IV and II-III species were electrochemically generated. Thus the new mononegative pentadentate ligand systems display significant flexibility in the range of Mn oxidation states and species...

How the Change in IBS Criteria From Rome III to Rome IV Impacts on Clinical Characteristics and Key Pathophysiological Factors.

Science.gov (United States)

Aziz, Imran; Törnblom, Hans; Palsson, Olafur S; Whitehead, William E; Simrén, Magnus

2018-06-08

The diagnostic criteria for irritable bowel syndrome (IBS) have recently been updated from Rome III to Rome IV. Whereas in Rome III a diagnosis of IBS entailed chronic abdominal pain or discomfort at least 3 days per month, in Rome IV the term discomfort has been removed and the frequency of abdominal pain increased to at least 1 day per week. We examined how this change in IBS criteria impacts on clinical characteristics and pathophysiological factors. A total of 542 Swedish subjects with Rome III IBS completed a baseline questionnaire enquiring for the number of abdominal pain days in the last 10 days; this was subsequently used as a surrogate marker to identify Rome IV IBS, in that (a) those with 0 or 1 day of pain were classed as Rome IV-negative, and (b) those with ≥2 days of pain were classed as Rome IV-positive. Comparisons were made between Rome IV-positive and -negative IBS groups for demographics, IBS subtype, gastrointestinal and psychological symptoms, somatisation, fatigue, disease-specific quality of life, rectal sensitivity, and oro-anal transit time. Overall, 85% of Rome III IBS patients fulfilled the Rome IV criteria for IBS, but 15% did not. Rome IV-positive subjects were significantly more likely to be female, have poorer quality of life, greater pain severity, bloating, somatisation, fatigue, and rectal sensitivity than Rome IV-negative subjects. There were no differences in severity of anxiety or depression, IBS subtypes, bowel habit dissatisfaction, or oro-anal transit time. Finally, increasing number of pain days correlated positively with symptoms and visceral hypersensitivity. Most Rome III-positive IBS patients seeking healthcare fulfil the Rome IV IBS criteria. They constitute a more severe group than those who lose their IBS diagnosis.

High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

Directory of Open Access Journals (Sweden)

Kilbride Seán M

2011-07-01

Full Text Available Abstract Background The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2 and complex IV (cytochrome c oxidase EC 1.9.3.1 are reduced by 30-70% in Huntington's disease and Alzheimer's disease, respectively, and are associated with excitotoxic cell death in these disorders. In this study, we investigated the control that complexes III and complex IV exert on glutamate release from the isolated nerve terminal. Results Inhibition of complex III activity by 60-90% was necessary for a major increase in the rate of Ca2+-independent glutamate release to occur from isolated nerve terminals (synaptosomes depolarized with 4-aminopyridine or KCl. Similarly, an 85-90% inhibition of complex IV activity was required before a major increase in the rate of Ca2+-independent glutamate release from depolarized synaptosomes was observed. Inhibition of complex III and IV activities by ~ 60% and above was required before rates of glutamate efflux from polarized synaptosomes were increased. Conclusions These results suggest that nerve terminal mitochondria possess high reserves of complex III and IV activity and that high inhibition thresholds must be reached before excess glutamate is released from the nerve terminal. The implications of the results in the context of the relationship between electron transport chain enzyme deficiencies and excitotoxicity in neurodegenerative disorders are discussed.

High-level inhibition of mitochondrial complexes III and IV is required to increase glutamate release from the nerve terminal

LENUS (Irish Health Repository)

Kilbride, Sean M

2011-07-26

Abstract Background The activities of mitochondrial complex III (ubiquinol-cytochrome c reductase, EC 1.10.2.2) and complex IV (cytochrome c oxidase EC 1.9.3.1) are reduced by 30-70% in Huntington\\'s disease and Alzheimer\\'s disease, respectively, and are associated with excitotoxic cell death in these disorders. In this study, we investigated the control that complexes III and complex IV exert on glutamate release from the isolated nerve terminal. Results Inhibition of complex III activity by 60-90% was necessary for a major increase in the rate of Ca2+-independent glutamate release to occur from isolated nerve terminals (synaptosomes) depolarized with 4-aminopyridine or KCl. Similarly, an 85-90% inhibition of complex IV activity was required before a major increase in the rate of Ca2+-independent glutamate release from depolarized synaptosomes was observed. Inhibition of complex III and IV activities by ~ 60% and above was required before rates of glutamate efflux from polarized synaptosomes were increased. Conclusions These results suggest that nerve terminal mitochondria possess high reserves of complex III and IV activity and that high inhibition thresholds must be reached before excess glutamate is released from the nerve terminal. The implications of the results in the context of the relationship between electron transport chain enzyme deficiencies and excitotoxicity in neurodegenerative disorders are discussed.

Hereditary sensory and autonomic neuropathies: types II, III, and IV

Directory of Open Access Journals (Sweden)

Axelrod Felicia B

2007-10-01

Full Text Available Abstract The hereditary sensory and autonomic neuropathies (HSAN encompass a number of inherited disorders that are associated with sensory dysfunction (depressed reflexes, altered pain and temperature perception and varying degrees of autonomic dysfunction (gastroesophageal reflux, postural hypotention, excessive sweating. Subsequent to the numerical classification of four distinct forms of HSAN that was proposed by Dyck and Ohta, additional entities continue to be described, so that identification and classification are ongoing. As a group, the HSAN are rare diseases that affect both sexes. HSAN III is almost exclusive to individuals of Eastern European Jewish extraction, with incidence of 1 per 3600 live births. Several hundred cases with HSAN IV have been reported. The worldwide prevalence of HSAN type II is very low. This review focuses on the description of three of the disorders, HSAN II through IV, that are characterized by autosomal recessive inheritance and onset at birth. These three forms of HSAN have been the most intensively studied, especially familial dysautonomia (Riley-Day syndrome or HSAN III, which is often used as a prototype for comparison to the other HSAN. Each HSAN disorder is likely caused by different genetic errors that affect specific aspects of small fiber neurodevelopment, which result in variable phenotypic expression. As genetic tests are routinely used for diagnostic confirmation of HSAN III only, other means of differentiating between the disorders is necessary. Diagnosis is based on the clinical features, the degree of both sensory and autonomic dysfunction, and biochemical evaluations, with pathologic examinations serving to further confirm differences. Treatments for all these disorders are supportive.

Kinetic Study on the Sorption of Te (IV), Ce (III) and Eu (III) on some Inorganic Ion Exchangers

International Nuclear Information System (INIS)

El-Sweify, F.H.; Shehata, M.K.K.; El-Shazly, E.A.A.

2008-01-01

The sorption behaviour of Te (IV), Ce (III) and Eu (III) on zirconium phosphate (Zr P) and ceric tungstate under various conditions was studied. Some factors affecting the sorption kinetics of the aforementioned metal ions on both ion exchangers were investigated. These factors were: hydrogen ion concentration in the absence of complexing agents, contact time, particle size of the two mentioned ion exchangers, metal in concentration and temperature. Radioactive isotopes were used for tracing the corresponding elements. Some physical parameters related to the sorption process were calculated from the obtained data

Pyrazolates advance cerium chemistry: a CeIII/CeIV redox equilibrium with benzoquinone.

Science.gov (United States)

Werner, Daniel; Deacon, Glen B; Junk, Peter C; Anwander, Reiner

2017-05-16

Two stable cerium(iv) 3,5-dialkylpyrazolate complexes are presented, namely dimeric [Ce(Me 2 pz) 4 ] 2 (Me 2 pz = 3,5-dimethylpyrazolate) and monomeric Ce(tBu 2 pz) 4 (tBu 2 pz = 3,5-di-tert-butylpyrazolate) along with their trivalent counterparts [Ce(Me 2 pz) 3 ] and [Ce(tBu 2 pz) 3 ] 2 . All complexes were obtained from protonolysis reactions employing the silylamide precursors Ce[N(SiHMe 2 ) 2 ] 4 and Ce[N(SiMe 3 ) 2 ] 3 . Treatment of homoleptic Ce IV and Ce III Me 2 pz complexes with 1,4-hydroquinone (H 2 hq) or 1,4-benzoquinone (bq), respectively, ultimately gave the same trimetallic Ce III species via a cerium redox equilibrium. The Ce III complex Ce 3 (Me 2 pz) 5 (pchd) 2 (L) (pchd = 1,4-bis(3,5-dimethylpyrazol-1-yl)cyclohex-2,5-diene-1,4-diolato; L = Me 2 pzH or (thf) 2 ) results from a di-1,4-pyrazolyl attack on pre-coordinated bq. The reduction of bq by [Ce(Me 2 pz) 3 (thf)] 2 , and re-oxidation by the resulting Ce IV species was supported by UV-vis spectroscopic investigations. Comparisons with the redox-innocent complexes [Ln(Me 2 pz) 3 (thf)] 2 (Ln = La and Pr) revealed far less selective reactions with bq, giving hexametallic and octametallic rare-earth metal side products containing 2-Me 2 pz substituted hq ligands.

Kinetics and mechanism of RuIII catalysed oxidation of 1,2,3,4-tetrahydro-naphthalene (tetralin) by CeIV in aqueous nitric acid medium

International Nuclear Information System (INIS)

Vijaya Bhaskar Rao, N.; Anand Rao, M.

2009-01-01

The kinetics and mechanism of Ru III catalysed oxidation of 1,2,3,4-tetrahydronaphthalene (tetralin) by Ce IV in aqueous nitric acid to tetralone under the conditions (TL) > > (Ce IV ) at different temperatures (30-50 deg C) have been studied in 3.0 mol dm -3 nitric acid medium. The experimentally observed rate law conforms to -d(Ce IV )/dt = kK(Ce IV )(TL)(Ru III )/l + K(TL) + K(Ru III ). (author)

Arthroscopic debridement for grade III and IV chondromalacia of the knee in patients older than 60 years.

Science.gov (United States)

van den Bekerom, Michel P J; Patt, Thomas W; Rutten, Sjoerd; Raven, Eric E J; van de Vis, Harm M V; Albers, G H Rob

2007-10-01

Arthroscopic debridement has been used to treat patients with degenerative knee osteoarthritis, although there is sometimes conflicting evidence documenting its efficacy. This study evaluates the success of arthroscopic debridement in elderly patients with grade III and IV chondromalacia of the knee as measured by patient satisfaction and the need for additional surgery. From December 1998 to August 2001, a total of 102 consecutive cases of knee arthroscopy in 99 patients > 60 years were performed. Average follow-up was 34 months (range: 7-104 months). Patients were asked about their satisfaction using a visual analog scale, and the presence of meniscal lesions during arthroscopy and the treatment for these lesions were evaluated. Knees also were assessed for articular surface degeneration using Outerbridge's classification for chondromalacia. The need for and type of additional surgery was evaluated. During arthroscopy, meniscal lesions requiring a partial meniscectomy were found in 95 knees. Chondromalacia was found in 92 knees; 53 knees had grade I or II chondromalacia and 39 knees had grade III or IV chondromalacia. Additional surgery was performed in 17 knees. Mean patient satisfaction score was 73 (range: 50-100) in the 39 knees with grade III or IV chondromalacia after arthroscopic debridement was performed. These findings suggest arthroscopic debridement in elderly patients has a place in the treatment algorithm for grade III or IV chondromalacia of the knee.

Cetuximab and Radiation Therapy in Treating Patients With Stage III-IV Head and Neck Cancer

Science.gov (United States)

2017-11-15

Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IVA Squamous Cell Carcinoma of the Larynx; Stage IVA Squamous Cell Carcinoma of the Oropharynx; Stage IVA Verrucous Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Larynx; Stage IVB Squamous Cell Carcinoma of the Oropharynx; Stage IVB Verrucous Carcinoma of the Larynx; Tongue Cancer

Directed synthesis of crystalline plutonium (III) and (IV) oxalates: accessing redox-controlled separations in acidic solutions

International Nuclear Information System (INIS)

Runde, Wolfgang; Brodnax, Lia F.; Goff, George S.; Bean, Amanda C.; Scott, Brian L.

2009-01-01

Both binary and ternary solid complexes of Pu(III) and Pu(IV) oxalates have been previously reported in the literature. However, uncertainties regarding the coordination chemistry and the extent of hydration of some compounds remain mainly because of the absence of any crystallographic characterization. Single crystals of hydrated oxalates of Pu(III), Pu 2 (C 2 O 4 ) 3 (H 2 O) 6 ·3H 2 O (I) and Pu(IV), KPu(C 2 O 4 ) 2 (OH)·2.5H 2 O (II), were synthesized under moderate hydrothermal conditions and characterized by single crystal X-ray diffraction studies. Compounds I and II are the first plutonium(III) or (IV) oxalate compounds to be structurally characterized via single crystal X-ray diffraction studies. Crystallographic data for I: monoclinic, space group P21/c, a = 11.246(3) A, b = 9.610(3) A, c = 10.315(3) A, Z = 4 and II: monoclinic, space group C2/c, a = 23.234(14) A, b = 7.502(4) A, c = 13.029(7) A, Z = 8.

Genetic diversity of internalin genes in the ascB-dapE locus among Listeria monocytogenes lineages III and IV strains.

Science.gov (United States)

Chen, Jianshun; Cheng, Changyong; Lv, Yonghui; Fang, Weihuan

2013-09-01

Listeria monocytogenes is an important foodborne pathogen encompassing four phylogenetic lineages. Lineages III and IV are rare, but have been reported to show considerable biodiversity, providing important clues for the evolutionary history in Listeria. In this study, analysis of the ascB-dapE locus reveals genetic diversity in lineages III and IV, and is consistent with the classification of sublineages. Four of the six genetic patterns (two of sublineage IIIC and two of lineage IV) are specific to these two lineages. The ascB-dapE locus suggests a hot spot for genome diversification, and serves as an attractive molecular marker for better understanding of the biodiversity and population structure of lineages III and IV strains. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Aufbau des humanoiden Roboters BART III

Science.gov (United States)

Resetov, Dimitri; Pietsch, Björn; Gerth, Wilfried

Der vorliegende Beitrag präsentiert den humanoiden Roboter BART III, der am Institut für Regelungstechnik als eine robuste und erweiterbare Plattform für weiterführende Grundlagenforschung zur zweibeinigen Fortbewegung entwickelt wurde. Im Gegensatz zu den bisher am IRT genutzten Robotern BARt-UH und LISA besitzt der neue Roboter einen beweglichen Oberkörper mit einem Bauchgelenk und Armen. BART III besitzt insgesamt 19 aktive Freiheitsgrade, 12 davon im Unterkörper. Ein weiteres Merkmal des Roboters ist die im gesamten Körper verteilte Ansteuerelektronik, die neben der lokalen Motorregelung diverse sicherheitsrelevante Funktionen übernimmt.

Adsorption and transformation of selected human-used macrolide antibacterial agents with iron(III) and manganese(IV) oxides

International Nuclear Information System (INIS)

Feitosa-Felizzola, Juliana; Hanna, Khalil; Chiron, Serge

2009-01-01

The adsorption/transformation of two members (clarithromycin and roxithromycin) of the macrolide (ML) antibacterial agents on the surface of three environmental subsurface sorbents (clay, iron(III) and manganese(IV) oxy-hydroxides) was investigated. The adsorption fitted well to the Freundlich model with a high sorption capacity. Adsorption probably occurred through a surface complexation mechanism and was accompanied by slow degradation of the selected MLs. Transformation proceeded through two parallel pathways: a major pathway was the hydrolysis of the cladinose sugar, and to a lesser extent the hydrolysis of the lactone ring. A minor pathway was the N-dealkylation of the amino sugar. This study indicates that Fe(III) and Mn(IV) oxy-hydroxides in aquatic sediments may play an important role in the natural attenuation of MLs. Such an attenuation route yields a range of intermediates that might retain some of their biological activity. - Iron(III) and manganese(IV) oxy-hydroxides in aquatic sediments may play an important role in the natural attenuation of macrolide antibacterial agents

Adsorption and transformation of selected human-used macrolide antibacterial agents with iron(III) and manganese(IV) oxides

Energy Technology Data Exchange (ETDEWEB)

Feitosa-Felizzola, Juliana [Laboratoire Chimie Provence, Aix-Marseille Universites-CNRS (UMR 6264), 3 place Victor Hugo, 13331 Marseille Cedex 3 (France); Hanna, Khalil [Laboratoire de Chimie Physique et Microbiologie pour l' Environnement, CNRS-Universite Henri Poincare-Nancy 1 (UMR 7564), 405 rue de Vandoeuvre, 54600 Villers-les-Nancy (France); Chiron, Serge [Laboratoire Chimie Provence, Aix-Marseille Universites-CNRS (UMR 6264), 3 place Victor Hugo, 13331 Marseille Cedex 3 (France)], E-mail: serge.chiron@univ-provence.fr

2009-04-15

The adsorption/transformation of two members (clarithromycin and roxithromycin) of the macrolide (ML) antibacterial agents on the surface of three environmental subsurface sorbents (clay, iron(III) and manganese(IV) oxy-hydroxides) was investigated. The adsorption fitted well to the Freundlich model with a high sorption capacity. Adsorption probably occurred through a surface complexation mechanism and was accompanied by slow degradation of the selected MLs. Transformation proceeded through two parallel pathways: a major pathway was the hydrolysis of the cladinose sugar, and to a lesser extent the hydrolysis of the lactone ring. A minor pathway was the N-dealkylation of the amino sugar. This study indicates that Fe(III) and Mn(IV) oxy-hydroxides in aquatic sediments may play an important role in the natural attenuation of MLs. Such an attenuation route yields a range of intermediates that might retain some of their biological activity. - Iron(III) and manganese(IV) oxy-hydroxides in aquatic sediments may play an important role in the natural attenuation of macrolide antibacterial agents.

Studies on the complexes of uranium(IV), thorium(IV) and lanthanum(III) acetates with p-aminobenzoic acid, m-aminobenzoic acid, benzilic acid and phthalic acid

International Nuclear Information System (INIS)

Singh, Mangal; Singh, Ajaib

1979-01-01

Complexes of acetates of U(IV), Th(IV) and La(III) with the ligands p-aminobenzoic acid, m-aminobenzoic acid, benzilic acid and phthalic acid have been prepared. Colour and chemical analytical data are recorded. They are characterised on the basis of IR and reflectance spectra and magnetic susceptibility data. (M.G.B.)

[Surgical treatment for talar neck fracture of Hawkins III, IV type with compression hollow screws combined with external fixator].

Science.gov (United States)

Wang, Xian-Xun; Wan, Chang-Tao; Yu, Li

2017-05-25

To investigate the clinical effects of compression hollow screws combined with external fixator in treating talar neck fracture of Hawkins III, IV type. From March 2010 to August 2014, 15 patients with talar neck fractures of Hawkins III, IV type were treated by open reduction and compression hollow screws fixation complicated with external fixator fixation. Including 9 males and 6 females, aged from 17 to 65 years old with an average of 37.5 years old. There were 9 cases of Hawkins III and 6 cases of Hawkins IV type. Postoperative radiographs and CT of ankle were used to evaluate the fracture healing and talar necrosis. The function of ankle and foot were evaluated by American Society of Ankle and Foot Surgery(AOFAS). All the patients were followed up for 8 to 55 months with an average of 23.5 months and all fractures got bone healing from 13 to 38 weeks with an average of (17.99±6.81) weeks. Traumatic arthritis occurred in 7 cases and talar necrosis in 6 cases (2 cases of type III and 4 cases of type IV) after operation. The average AOFAS score was 61.80±18.75, including excellent in 4 cases, good in 2 cases, fair in 4 cases and poor in 5 cases. Talar neck fracture with Hawkins III, IV type has large possibility to develop avascular necrosis. Hollow compression screw combined with external fixation may late weight-bearing for ankle and can sufficiently guarantee bone healing time, and achieve good results for the treatment of talar neck fracture.

Facing Contrast-Enhancing Gliomas: Perfusion MRI in Grade III and Grade IV Gliomas according to Tumor Area

Directory of Open Access Journals (Sweden)

Anna Luisa Di Stefano

2014-01-01

Full Text Available Tumoral neoangiogenesis characterizes high grade gliomas. Relative Cerebral Blood Volume (rCBV, calculated with Dynamic Susceptibility Contrast (DSC Perfusion-Weighted Imaging (PWI, allows for the estimation of vascular density over the tumor bed. The aim of the study was to characterize putative tumoral neoangiogenesis via the study of maximal rCBV with a Region of Interest (ROI approach in three tumor areas—the contrast-enhancing area, the nonenhancing tumor, and the high perfusion area on CBV map—in patients affected by contrast-enhancing glioma (grades III and IV. Twenty-one patients were included: 15 were affected by grade IV and 6 by grade III glioma. Maximal rCBV values for each patient were averaged according to glioma grade. Although rCBV from contrast-enhancement and from nonenhancing tumor areas was higher in grade IV glioma than in grade III (5.58 and 2.68; 3.01 and 2.2, resp., the differences were not significant. Instead, rCBV recorded in the high perfusion area on CBV map, independently of tumor compartment, was significantly higher in grade IV glioma than in grade III (7.51 versus 3.78, P=0.036. In conclusion, neoangiogenesis encompasses different tumor compartments and CBV maps appear capable of best characterizing the degree of neovascularization. Facing contrast-enhancing brain tumors, areas of high perfusion on CBV maps should be considered as the reference areas to be targeted for glioma grading.

The cost of unresectable stage III or stage IV melanoma in Italy

Directory of Open Access Journals (Sweden)

Maio Michele

2012-11-01

Full Text Available Abstract Background In recent decades, melanoma incidence has been increasing in European countries; in 2006, there were approximately 60,000 cases leading to 13,000 deaths. Within Europe there is some geographical variation in the incidence of melanoma, with the highest rates reported in Scandinavia (15 cases per 100,000 inhabitants per year and the lowest in the Mediterranean countries (5 to 7 cases per 100,000 inhabitants per year. Methods The present article is based on the information collected in the MELODY study (MELanoma treatment patterns and Outcomes among patients with unresectable stage III or stage IV Disease: a retrospective longitudinal survey. In that study, the medical charts of patients were reviewed to document current treatment patterns and to analyse information on patients, disease characteristics and healthcare resource utilization related to the treatment of advanced melanoma regarding patients who presented with a diagnosis of malignant melanoma (stage I to IV at participating sites between 01 July, 2005 and 30 June, 2006. Results Summarizing, though the length of the follow-up period varies among sample patients, an amount of the yearly cost per patient can be estimated, dividing the average per patient total cost (€ 5.040 by the average follow-up duration (17.5 months and reporting to one year; on these grounds, unresectable stage III or stage IV melanoma in Italy would cost € 3,456 per patient per year.

Differentiation of grade II/III and grade IV glioma by combining ''T1 contrast-enhanced brain perfusion imaging'' and susceptibility-weighted quantitative imaging

International Nuclear Information System (INIS)

Saini, Jitender; Gupta, Pradeep Kumar; Gupta, Rakesh Kumar; Sahoo, Prativa; Singh, Anup; Patir, Rana; Ahlawat, Suneeta; Beniwal, Manish; Thennarasu, K.; Santosh, Vani

2018-01-01

MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients. rCBV and ITSS values were compared to seek differences between grade II vs. grade III, grade III vs. grade IV, and grade III+II vs. grade IV tumors. Significant differences in rCBV values of the three grades of the tumors were noted and pairwise comparisons showed significantly higher rCBV values in grade IV tumors as compared to grade III tumors, and similarly increased rCBV was seen in the grade III tumors as compared to grade II tumors (p < 0.001). Grade IV gliomas showed significantly higher ITSS scores on SWI as compared to grade III tumors (p < 0.001) whereas insignificant difference was seen on comparing ITSS scores of grade III with grade II tumors. Combining the rCBV and ITSS resulted in significant improvement in the discrimination of grade III from grade IV tumors. The combination of rCBV values derived from T1-perfusion MRI and SWI derived ITSS scores improves the diagnostic accuracy for discrimination of grade III from grade IV gliomas. (orig.)

Differentiation of grade II/III and grade IV glioma by combining ''T1 contrast-enhanced brain perfusion imaging'' and susceptibility-weighted quantitative imaging

Energy Technology Data Exchange (ETDEWEB)

Saini, Jitender [National Institute of Mental Health and Neurosciences, Neuroimaging and Interventional Radiology, Bangalore (India); Gupta, Pradeep Kumar; Gupta, Rakesh Kumar [Fortis Memorial Research Institute, Department of Radiology and Imaging, Gurugram (India); Sahoo, Prativa [Philips Health System, Philips India Limited, Bangalore (India); Beckman Research Institute, Mathematical Oncology, Duarte, CA (United States); Singh, Anup [Indian Institute of Technology Delhi, Center for Biomedical Engineering, Delhi (India); Patir, Rana [Fortis Memorial Research Institute, Department of Neurosurgery, Gurugram (India); Ahlawat, Suneeta [Fortis Memorial Research Institute, SRL Diagnostics, Gurugram (India); Beniwal, Manish [National Institute of Mental Health and Neurosciences, Department of Neurosurgery, Bangalore (India); Thennarasu, K. [National Institute of Mental Health and Neurosciences, Department of Biostatistics, Bangalore (India); Santosh, Vani [National Institute of Mental Health and Neurosciences, Department of Neuropathology, Bangalore (India)

2018-01-15

MRI is a useful method for discriminating low- and high-grade glioma using perfusion MRI and susceptibility-weighted imaging (SWI). The purpose of this study is to evaluate the usefulness of T1-perfusion MRI and SWI in discriminating among grade II, III, and IV gliomas. T1-perfusion MRI was used to measure relative cerebral blood volume (rCBV) in 129 patients with glioma (70 grade IV, 33 grade III, and 26 grade II tumors). SWI was also used to measure the intratumoral susceptibility signal intensity (ITSS) scores for each tumor in these patients. rCBV and ITSS values were compared to seek differences between grade II vs. grade III, grade III vs. grade IV, and grade III+II vs. grade IV tumors. Significant differences in rCBV values of the three grades of the tumors were noted and pairwise comparisons showed significantly higher rCBV values in grade IV tumors as compared to grade III tumors, and similarly increased rCBV was seen in the grade III tumors as compared to grade II tumors (p < 0.001). Grade IV gliomas showed significantly higher ITSS scores on SWI as compared to grade III tumors (p < 0.001) whereas insignificant difference was seen on comparing ITSS scores of grade III with grade II tumors. Combining the rCBV and ITSS resulted in significant improvement in the discrimination of grade III from grade IV tumors. The combination of rCBV values derived from T1-perfusion MRI and SWI derived ITSS scores improves the diagnostic accuracy for discrimination of grade III from grade IV gliomas. (orig.)

Co-precipitation of plutonium(IV) and americium(III) from nitric acid-oxalic acid solutions with bismuth oxalate

International Nuclear Information System (INIS)

Pius, I.C.; Noronha, D.M.; Chaudhury, Satyajeet

2017-01-01

Co-precipitation of plutonium and americium from nitric acid-oxalic acid solutions with bismuth oxalate has been investigated for the removal of these long lived α-active nuclides from waste solutions. Effect of concentration of bismuth and oxalic acid on the co-precipitation of Pu(IV) from 3 M HNO_3 has been investigated. Similar experiments were also carried out from 3.75 M HNO_3 on co-precipitation of Am(III) to optimize the conditions of precipitation. Strong co-precipitation of Pu(IV) and Am(III) with bismuth oxalate indicate feasibility of treatment of plutonium and americium bearing waste solutions. (author)

11. IV avati Draakoni galeriis...

Index Scriptorium Estoniae

2005-01-01

Tanel Saare (sünd. 1979) näitus "Gott und huhn episode IV: seed shower". Eksponeeritakse väljavõtteid aktsioonidest aastatel 2000-2004 Turus, Nürnbergis, Berliinis, Lohusalus ja Soulis. Osa aktsioone toimus koos rühmitusega Non Grata

A proteomics panel for predicting optimal primary cytoreduction in stage III/IV ovarian cancer

DEFF Research Database (Denmark)

Risum, Signe; Høgdall, Estrid; Engelholm, Svend A

2009-01-01

for CA-125. In addition, serum was analyzed for 7 biomarkers using surface-enhanced laser desorption/ionization time-of-flight mass spectrometry. These biomarkers were combined into a single-valued ovarian-cancer-risk index (OvaRI). CA-125 and OvaRI were evaluated as predictors of cytoreduction in 75......The objective of this prospective study was to evaluate CA-125 and a 7-marker panel as predictors of incomplete primary cytoreduction in patients with stage III/IV ovarian cancer (OC). From September 2004 to January 2008, serum from 201 patients referred to surgery for a pelvic tumor was analyzed...... stage III/IV patients using receiver operating characteristic curves. Complete primary cytoreduction (no macroscopic residual disease) was achieved in 31% (23/75) of the patients. The area under the receiver operating characteristic curve was 0.66 for CA-125 and 0.75 for OvaRI. The sensitivity...

Studies on Pu(IV)/(III)-oxalate precipitation from nitric acid containing high concentration of calcium and fluoride ions

International Nuclear Information System (INIS)

Kalsi, P.K.; Pawar, S.M.; Ghadse, D.R.; Joshi, A.R.; Ramakrishna, V.V.; Vaidya, V.N.; Venugopal, V.

2003-01-01

Plutonium (IV)/(III) oxalate precipitation from nitric acid solution, containing large amount of calcium and fluoride ions was investigated. It was observed that direct precipitation of Pu (IV) oxalate from nitric acid containing large amount of calcium and fluoride ions did not give good decontamination of Pu from calcium and fluoride impurities. However, incorporation of hydroxide precipitation using ammonium hydroxide prior to Pu (IV) oxalate precipitation results into PuO 2 with much less calcium and fluoride impurities. Whereas, good decontamination from calcium and fluoride impurities could be obtained by employing Pu (III) oxalate precipitation directly from nitric acid containing large amount of calcium and fluoride ions. A method was also developed to recover Pu from the oxalate waste containing calcium and fluoride ions. (author)

CANDU technology for generation III + AND IV reactors

International Nuclear Information System (INIS)

Torgerson, D.F.

2005-01-01

Atomic Energy of Canada Limited (AECL) is the original developer of the CANDU?reactor, one of the three major commercial power reactor designs now used throughout the world. For over 60 years, AECL has continued to evolve the CANDU design from the CANDU prototypes in the 1950s and 1960s through to the second generation reactors now in operation, including the Generation II+ CANDU 6. The next phase of this evolution, the Generation III+ Advanced CANDU ReactorTM (ACRTM), continues the strategy of basing next generation technology on existing CANDU reactors. Beyond the ACR, AECL is developing the Generation IV CANDU Super Critical Water Reactor. Owing to the evolutionary nature of these advanced reactors, advanced technology from the development programs is also being applied to operating CANDU plants, for both refurbishments and upgrading of existing systems and components. In addition, AECL is developing advanced technology that covers the entire life cycle of the CANDU plant, including waste management and decommissioning. Thus, AECL maintains state-of-the-art expertise and technology to support both operating and future CANDU plants. This paper outlines the scale of the current core knowledge base that is the foundation for advancement and support of CANDU technology. The knowledge base includes advancements in materials, fuel, safety, plant operations, components and systems, environmental technology, waste management, and construction. Our approach in each of these areas is to develop the underlying science, carry out integrated engineering scale tests, and perform large-scale demonstration testing. AECL has comprehensive R and D and engineering development programs to cover all of these elements. The paper will show how the ongoing expansion of the CANDU knowledge base has led to the development of the Advanced CANDU Reactor. The ACR is a Generation III+ reactor with substantially reduced costs, faster construction, and enhanced passive safety and operating

Bioenergetics and ATP Synthesis during Exercise: Role of Group III/IV Muscle Afferents.

Science.gov (United States)

Broxterman, Ryan M; Layec, Gwenael; Hureau, Thomas J; Morgan, David E; Bledsoe, Amber D; Jessop, Jacob E; Amann, Markus; Richardson, Russell S

2017-12-01

The purpose of this study was to investigate the role of the group III/IV muscle afferents in the bioenergetics of exercising skeletal muscle beyond constraining the magnitude of metabolic perturbation. Eight healthy men performed intermittent isometric knee-extensor exercise to task failure at ~58% maximal voluntary contraction under control conditions (CTRL) and with lumbar intrathecal fentanyl to attenuate group III/IV leg muscle afferents (FENT). Intramuscular concentrations of phosphocreatine (PCr), inorganic phosphate (Pi), diprotonated phosphate (H2PO4), adenosine triphosphate (ATP), and pH were determined using phosphorous magnetic resonance spectroscopy (P-MRS). The magnitude of metabolic perturbation was significantly greater in FENT compared with CTRL for [Pi] (37.8 ± 16.8 vs 28.6 ± 8.6 mM), [H2PO4] (24.3 ± 12.2 vs 17.9 ± 7.1 mM), and [ATP] (75.8% ± 17.5% vs 81.9% ± 15.8% of baseline), whereas there was no significant difference in [PCr] (4.5 ± 2.4 vs 4.4 ± 2.3 mM) or pH (6.51 ± 0.10 vs 6.54 ± 0.14). The rate of perturbation in [PCr], [Pi], [H2PO4], and pH was significantly faster in FENT compared with CTRL. Oxidative ATP synthesis was not significantly different between conditions. However, anaerobic ATP synthesis, through augmented creatine kinase and glycolysis reactions, was significantly greater in FENT than in CTRL, resulting in a significantly greater ATP cost of contraction (0.049 ± 0.016 vs 0.038 ± 0.010 mM·min·N). Group III/IV muscle afferents not only constrain the magnitude of perturbation in intramuscular Pi, H2PO4, and ATP during small muscle mass exercise but also seem to play a role in maintaining efficient skeletal muscle contractile function in men.

Organic / IV, III-V Semiconductor Hybrid Solar Cells

Directory of Open Access Journals (Sweden)

Pang-Leen Ong

2010-03-01

Full Text Available We present a review of the emerging class of hybrid solar cells based on organic-semiconductor (Group IV, III-V, nanocomposites, which states separately from dye synthesized, polymer-metal oxides and organic-inorganic (Group II-VI nanocomposite photovoltaics. The structure of such hybrid cell comprises of an organic active material (p-type deposited by coating, printing or spraying technique on the surface of bulk or nanostructured semiconductor (n-type forming a heterojunction between the two materials. Organic components include various photosensitive monomers (e.g., phtalocyanines or porphyrines, conjugated polymers, and carbon nanotubes. Mechanisms of the charge separation at the interface and their transport are discussed. Also, perspectives on the future development of such hybrid cells and comparative analysis with other classes of photovoltaics of third generation are presented.

Dependence of the Ce(iii)/Ce(iv) ratio on intracellular localization in ceria nanoparticles internalized by human cells

KAUST Repository

Ferraro, Daniela

2017-01-09

CeO2 nanoparticles (CNPs) have been investigated as promising antioxidant agents with significant activity in the therapy of diseases involving free radicals or oxidative stress. However, the exact mechanism responsible for CNP activity has not been completely elucidated. In particular, in situ evidence of modification of the oxidative state of CNPs in human cells and their evolution during cell internalization and subsequent intracellular distribution has never been presented. In this study we investigated modification of the Ce(iii)/Ce(iv) ratio following internalization in human cells by X-ray absorption near edge spectroscopy (XANES). From this analysis on cell pellets, we observed that CNPs incubated for 24 h showed a significant increase in Ce(iii). By coupling on individual cells synchrotron micro-X-ray fluorescence (μXRF) with micro-XANES (μXANES) we demonstrated that the Ce(iii)/Ce(iv) ratio is also dependent on CNP intracellular localization. The regions with the highest CNP concentrations, suggested to be endolysosomes by transmission electron microscopy, were characterized by Ce atoms in the Ce(iv) oxidation state, while a higher Ce(iii) content was observed in regions surrounding these areas. These observations suggest that the interaction of CNPs with cells involves a complex mechanism in which different cellular areas play different roles.

Dependence of the Ce(iii)/Ce(iv) ratio on intracellular localization in ceria nanoparticles internalized by human cells

KAUST Repository

Ferraro, Daniela; Tredici, Ilenia G.; Ghigna, Paolo; Castillio-Michel, Hiram; Falqui, Andrea; Di Benedetto, Cristiano; Alberti, Giancarla; Ricci, Vittorio; Anselmi-Tamburini, Umberto; Sommi, Patrizia

2017-01-01

CeO2 nanoparticles (CNPs) have been investigated as promising antioxidant agents with significant activity in the therapy of diseases involving free radicals or oxidative stress. However, the exact mechanism responsible for CNP activity has not been completely elucidated. In particular, in situ evidence of modification of the oxidative state of CNPs in human cells and their evolution during cell internalization and subsequent intracellular distribution has never been presented. In this study we investigated modification of the Ce(iii)/Ce(iv) ratio following internalization in human cells by X-ray absorption near edge spectroscopy (XANES). From this analysis on cell pellets, we observed that CNPs incubated for 24 h showed a significant increase in Ce(iii). By coupling on individual cells synchrotron micro-X-ray fluorescence (μXRF) with micro-XANES (μXANES) we demonstrated that the Ce(iii)/Ce(iv) ratio is also dependent on CNP intracellular localization. The regions with the highest CNP concentrations, suggested to be endolysosomes by transmission electron microscopy, were characterized by Ce atoms in the Ce(iv) oxidation state, while a higher Ce(iii) content was observed in regions surrounding these areas. These observations suggest that the interaction of CNPs with cells involves a complex mechanism in which different cellular areas play different roles.

Fosaprepitant Dimeglumine, Palonosetron Hydrochloride, and Dexamethasone in Preventing Nausea and Vomiting Caused by Cisplatin in Patients With Stage III or Stage IV Head and Neck Cancer Undergoing Chemotherapy and Radiation Therapy

Science.gov (United States)

2017-04-13

Nausea and Vomiting; Stage III Squamous Cell Carcinoma of the Hypopharynx; Stage III Squamous Cell Carcinoma of the Larynx; Stage III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx

Biometrische Untersuchungen des Stylopodiums, Zygopodiums und Metapodiums pleistozäner Ursiden im Hinblick auf die Evolution des Höhlenbären und die Klassifizierung des Fundmaterials Einhornhöhle / Harz

OpenAIRE

Athen, Kerstin Anja

2007-01-01

In der vorliegenden Dissertation "Biometrische Untersuchungen des Stylopodiums, Zygopodiums und Metapodiums pleistozäner Ursiden im Hinblick auf die Evolution des Höhlenbären und die Klassifizierung des Fundmaterials Einhornhöhle / Harz" wurden Daten des oberpliozänen Ursus etruscus, des pleistozänen Ursus deningeri sowie des Ursus spelaeus ausgewertet. Zur Datenerhebung wurden 249 Messgrößen an den Skelettelementen Humerus, Ulna, Radius, Metacarpalia I-V, Femur, Tibia, Fibula und Metatarsali...

Complexation of some trivalent lanthanides, scandium(III) and thorium(IV) by benzylidenepyruvates in aqueous solution

International Nuclear Information System (INIS)

Marques, R.N.; Moraes, M. de; Ionashiro, M.

1997-01-01

The protonation constants of 4-methylbenzylidenepyruvate (4Me-BP) and 4-isopropylbenzylidenepyruvate (4IP-BP) as well as the stability constants of their binary 1:1 complexes with Cu(II), La(III), Pr(III), Sm(III), Eu(III), Yb(III), Sc(III) and Th(IV) have been determined spectrophotometrically in aqueous solution at 25 C and ionic strength 0.500 M, maintained with sodium perchlorate. For all metal ions considered, the stability changes move in the same direction as the pK a of the ligands. Linear free energy relationships, as applied to oxygen donor substances, suggest the -COCOO - moiety as the metal binding site of the ligands. The results are discussed mainly taking into account that benzylidenepyruvates, besides the α-keto canonical form, may display other forms in aqueous solution with changing pH and the possible occurrence of extra intra-ligand charge polarization, induced by metal ions. (orig.)

A new oxidimetric reagent: potassium dichromate in a strong phosphoric acid medium-VI Potentiometric titration of vanadium(III) alone and in mixture with vanadium(IV).

Science.gov (United States)

Rao, G G; Rao, P K

1966-09-01

Vanadium(III) can be titrated at room temperature with potassium dichromate in an 8-12M phosphoric acid medium. Two potential breaks are observed in 12M phosphoric add with 0.2N potassium dichromate, the first corresponding to the oxidation of vanadium(III) to vanadium(IV) and the second to the oxidation of vanadium(IV) to vanadium(V). In titrations with 0.05N dichromate only the first break in potential is clearly observed. The method has been extended to the titration of mixtures of vanadium(III) and vanadium(IV). Conditions have also been found for the visual titration of vanadium(III) using ferroln or barium diphenylamine sulphonate as indicator.

Liquid–liquid extraction of Pu(IV), U(VI) and Am(III) using malonamide in room temperature ionic liquid as diluent

International Nuclear Information System (INIS)

Rout, Alok; Venkatesan, K.A.; Srinivasan, T.G.; Vasudeva Rao, P.R.

2012-01-01

Highlights: ► Extraction of actinides using malonamide in room temperature ionic liquid. ► High distribution ratios of actinides in room temperature ionic liquid. ► Ion exchange mechanism. ► Stoichiometry of extraction. ► High separation factors of U(VI) and Pu(IV) over Am(III) and fission products. - Abstract: The extraction behavior of U(VI), Pu(IV) and Am(III) from nitric acid medium by a solution of N,N-dimethyl-N,N-dioctyl-2-(2-hexyloxyethyl)malonamide (DMDOHEMA) in the room temperature ionic liquid, 1–butyl–3–methylimidazolium bis(trifluoromethanesulfonyl)imide (C 4 mimNTf 2 ), was studied. The distribution ratio of these actinides in DMDOHEMA/C 4 mimNTf 2 was measured as a function of various parameters such as the concentration of nitric acid, DMDOHEMA, NTf 2 − , alkyl chain length of ionic liquid. The extraction of actinides in the absence of DMDOHEMA was insignificant and the distribution ratio achieved in conjunction with C 4 mimNTf 2 , was remarkable. The separation factor of U(VI) and Pu(IV) achieved with the use of DMDOHEMA, ionic liquid was compared with Am(III) and other fission products. The stoichiometry of the metal-solvate was determined to be 1:2 for U(VI) and Pu(IV) and 1:3 for Am(III).

Palliative Care in Improving Quality of Life and Symptoms in Patients With Stage III-IV Pancreatic or Ovarian Cancer

Science.gov (United States)

2014-12-18

Recurrent Ovarian Epithelial Cancer; Recurrent Ovarian Germ Cell Tumor; Recurrent Pancreatic Cancer; Stage III Pancreatic Cancer; Stage IIIA Ovarian Epithelial Cancer; Stage IIIA Ovarian Germ Cell Tumor; Stage IIIB Ovarian Epithelial Cancer; Stage IIIB Ovarian Germ Cell Tumor; Stage IIIC Ovarian Epithelial Cancer; Stage IIIC Ovarian Germ Cell Tumor; Stage IV Ovarian Epithelial Cancer; Stage IV Ovarian Germ Cell Tumor; Stage IV Pancreatic Cancer

[Nordosteuropa als Geschichtsregion. Beiträge des III. Internationalen Symposiums zur deutschen Kultur und Geschichte im europäischen Nordosten vom 20.-22. September 2001 in Tallinn

Index Scriptorium Estoniae

Lawaty, Andreas

2011-01-01

Arvustus : Nordosteuropa als Geschichtsregion. Beiträge des III. Internationalen Symposiums zur deutschen Kultur und Geschichte im europäischen Nordosten vom 20.-22. September 2001 in Tallinn. Lübeck : Verlag Schmidt-Römhild 2006. (Veröffentlihungen der Aue-Stiftung. 17)

Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

Science.gov (United States)

Nader, Anne-Marie; Jelenic, Patricia; Soulières, Isabelle

2015-01-01

The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV), for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of “autism”. The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger’s Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence. PMID:26673881

Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

Science.gov (United States)

Nader, Anne-Marie; Jelenic, Patricia; Soulières, Isabelle

2015-01-01

The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV), for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of "autism". The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger's Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence.

Discrepancy between WISC-III and WISC-IV Cognitive Profile in Autism Spectrum: What Does It Reveal about Autistic Cognition?

Directory of Open Access Journals (Sweden)

Anne-Marie Nader

Full Text Available The cognitive profile and measured intellectual level vary according to assessment tools in children on the autism spectrum, much more so than in typically developing children. The recent inclusion of intellectual functioning in the diagnostic process for autism spectrum disorders leads to the crucial question on how to assess intelligence in autism, especially as some tests and subtests seem more sensitive to certain neurodevelopmental conditions. Our first aim was to examine the cognitive profile on the current version of the most widely used test, the Wechsler Intelligence Scales for Children (WISC-IV, for a homogenous subgroup of children on the autism spectrum, i.e. corresponding to DSM-IV diagnosis of "autism". The second aim was to compare cognitive profiles obtained on the third edition versus 4th edition of WISC, in order to verify whether the WISC-IV yields a more distinctive cognitive profile in autistic children. The third aim was to examine the impact of the WISC-IV on the cognitive profile of another subgroup, children with Asperger's Syndrome. 51 autistic, 15 Asperger and 42 typically developing children completed the WISC-IV and were individually matched to children who completed the WISC-III. Divergent WISC-IV profiles were observed despite no significant intelligence quotient difference between groups. Autistic children scored significantly higher on the Perceptual Reasoning Index than on the Verbal Comprehension Index, a discrepancy that nearly tripled in comparison to WISC-III results. Asperger children scored higher on the VCI than on other indexes, with the lowest score found on the Processing Speed Index. WISC-IV cognitive profiles were consistent with, but more pronounced than WISC-III profiles. Cognitive profiles are a valuable diagnostic tool for differential diagnosis, keeping in mind that children on the autism spectrum might be more sensitive to the choice of subtests used to assess intelligence.

Phase II study of ipilimumab in adolescents with unresectable stage III or IV malignant melanoma

DEFF Research Database (Denmark)

Geoerger, Birgit; Bergeron, Christophe; Gore, Lia

2017-01-01

BACKGROUND: Ipilimumab is approved for the treatment of advanced melanoma in adults; however, little information on the efficacy and safety of ipilimumab in younger patients is available. METHODS: Patients aged 12 to <18 years with previously treated or untreated, unresectable stage III or IV mal...

Lehre am Puls der Zeit - Global Health in der Medizinischen Ausbildung: Positionen, Lernziele und methodische Empfehlungen [Cutting-Edge Education - Global Health in Medical Training: Prosposals, Educational Objectives and Methodological Recommendations

Directory of Open Access Journals (Sweden)

Bozorgmehr, Kayvan

2009-05-01

Full Text Available [english] Aim: To formulate a guideline on educational objectives and methodology for the implementation of the cross-disciplinary subject “Global Health” in German medical education, on the initiative of the German Medical Students’ Association (bvmd Germany. Methods: For this purpose, the Globalisation and Health Initiative (GandHI of bvmd Germany established the “Global Health Curriculum” working group in May 2008. Review and assessment of available international literature regarding Global Health in medical education. Multilevel consensus development process from May 2008 to January 2009 by means of workshops, group discussions, teleconferences, and e-mail. Results: The bvmd Germany calls for The formulation of 15 general educational objectives based on proposals (ii and (iii. Three clusters shall formulate specific objectives: Regarding form, duration, and implementation of courses. [german] Zielsetzung: Formulierung einer Leitlinie zu Lernzielen und der praktischen Umsetzung eines disziplinübergreifenden Fachgebiets „Global Health“ für die medizinische Ausbildung in Deutschland aus Sicht der Bundesvertretung der Medizinstudierenden (bvmd. Methodik: Initiierung des Arbeitskreises „Global Health Curriculum“ innerhalb der Globalisation and Health Initiative (GandHI der bvmd im Mai 2008. Nicht-systematische Recherche und Bewertung nationaler und internationaler Literatur zu Global Health in der medizinischen Ausbildung. Mehrstufiger Konsensbildungsprozess von Mai 2008 bis Januar 2009 durch Workshops, Arbeitstreffen, Gruppendiskussionen, Telefonkonferenzen und Email-Kommunikation, initiert und koordiniert durch den Arbeitskreis „Global Health Curriculum“ der GandHI. Ergebnisse: : Die bvmd plädiert für Formulierung von 15 allgemeinen Lernzielen, aufbauend auf den Positionen (ii und (iii. Bestehend aus Aufbauend auf Position (iv wird nahe gelegt, entsprechende Kurse als Tagesveranstaltung in Seminarform mit einer Dauer

Diversity of the Germination Apparatus in Clostridium botulinum Groups I, II, III and IV

Directory of Open Access Journals (Sweden)

Jason Brunt

2016-10-01

Full Text Available Clostridium botulinum is a highly dangerous pathogen that forms very resistant endospores that are ubiquitous in the environment, and which, under favourable conditions germinate to produce vegetative cells that multiply and form the exceptionally potent botulinum neurotoxin. To improve the control of botulinum neurotoxin-forming clostridia, it is important to understand the mechanisms involved in spore germination. Here we present models for spore germination in C. botulinum based on comparative genomics analyses, with C. botulinum Groups I and III sharing similar pathways, which differ from those proposed for C. botulinum Groups II and IV. All spores germinate in response to amino acids interacting with a germinant receptor, with four types of germinant receptor identified (encoded by various combinations of gerA, gerB and gerC genes (gerX. There are three gene clusters with an ABC-like configuration; ABC gerX1, ABABCB gerX2 and ACxBBB gerX4, and a single CA-B gerX3 gene cluster. Subtypes have been identified for most germinant receptors types, and the individual GerX subunits of each cluster show similar grouping in phylogenetic trees. C. botulinum Group I contained the largest variety of gerX subtypes, with three gerX1, three gerX2 and one gerX3 subtypes, while C. botulinum Group III contained two gerX1 types and one gerX4. C. botulinum Groups II and IV contained a single germinant receptor, gerX3 and gerX1, respectively. It is likely that all four C. botulinum Groups include a SpoVA channel involved in DPA release. The cortex lytic enzymes present in C. botulinum Groups I and III appear to be CwlJ and SleB, while in C. botulinum Groups II and IV, SleC appears to be important.

Design of fractional order differentiator using type-III and type-IV discrete cosine transform

Directory of Open Access Journals (Sweden)

Manjeet Kumar

2017-02-01

Full Text Available In this paper, an interpolation method based on discrete cosine transform (DCT is employed for digital finite impulse response-fractional order differentiator (FIR-FOD design. Here, a fractional order digital differentiator is modeled as finite impulse response (FIR system to get an optimized frequency response that approximates the ideal response of a fractional order differentiator. Next, DCT-III and DCT-IV are utilized to determine the filter coefficients of FIR filter that compute the Fractional derivative of a given signal. To improve the frequency response of the proposed FIR-FOD, the filter coefficients are further modified using windows. Several design examples are presented to demonstrate the superiority of the proposed method. The simulation results have also been compared with the existing FIR-FOD design methods such as DFT interpolation, radial basis function (RBF interpolation, DCT-II interpolation and DST interpolation methods. The result reveals that the proposed FIR-FOD design technique using DCT-III and DCT-IV outperforms DFT interpolation, RBF interpolation, DCT-II interpolation and DST interpolation methods in terms of magnitude error.

ACME-III and ACME-IV Final Campaign Reports

Energy Technology Data Exchange (ETDEWEB)

Biraud, S. C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)

2016-01-01

The goals of the Atmospheric Radiation Measurement (ARM) Climate Research Facility’s third and fourth Airborne Carbon Measurements (ACME) field campaigns, ACME-III and ACME-IV, are: 1) to measure and model the exchange of CO₂, water vapor, and other greenhouse gases by the natural, agricultural, and industrial ecosystems of the Southern Great Plains (SGP) region; 2) to develop quantitative approaches to relate these local fluxes to the concentration of greenhouse gases measured at the Central Facility tower and in the atmospheric column above the ARM SGP Central Facility, 3) to develop and test bottom-up measurement and modeling approaches to estimate regional scale carbon balances, and 4) to develop and test inverse modeling approaches to estimate regional scale carbon balance and anthropogenic sources over continental regions. Regular soundings of the atmosphere from near the surface into the mid-troposphere are essential for this research.

Samarium (III Selective Membrane Sensor Based on Tin (IV Boratophosphate

Directory of Open Access Journals (Sweden)

Ashok S. K. Kumar

2004-08-01

Full Text Available Abstract: A number of Sm (III selective membranes of varying compositions using tin (IV boratophosphate as electroactive material were prepared. Polyvinyl chloride, polystyrene and epoxy resin were used as binding materials. Membrane having composition of 40% exchanger and 60% epoxy resin exhibited best performance. This membrane worked well over a wide concentration range of 1x10-5M to 1x10-1 M of samarium ions with a Super-Nernstian slope of 40 mV/decade. It has a fast response time of less than 10 seconds and can be used for at least six months without any considerable divergence in potentials. The proposed sensor revealed good selectivities with respect to alkali, alkaline earth, some transition and rare earth metal ions and can be used in the pH range of 4.0-10.0. It was used as an indicator electrode in the potentiometric titration of Sm (III ions against EDTA. Effect of internal solution was studied and the electrode was successfully used in non-aqueous media, too.

Novel Cryptosporidium bat genotypes III and IV in bats from the USA and Czech Republic.

Science.gov (United States)

Kváč, Martin; Hořická, Anna; Sak, Bohumil; Prediger, Jitka; Salát, Jiří; Širmarová, Jana; Bartonička, Tomáš; Clark, Mark; Chelladurai, Jeba Rose Jennifer Jesudoss; Gillam, Erin; McEvoy, John

2015-10-01

Bats from the families Rhinolophidae (n = 90) and Vespertilionidae (n = 191) in the USA and Czech Republic were screened for the presence of Cryptosporidium by microscopic and molecular analysis of faecal samples collected from rectum of dissected animals and from the ground beneath roosting sites. Cryptosporidium oocysts were not detected in any of the 281 faecal specimens examined using the aniline-carbol-methyl violet staining method. Nested PCR amplification, sequencing and phylogenetic analysis of the small ribosomal subunit rRNA and actin genes were used to identify isolates and infer evolutionary relationships. Cryptosporidium parvum was identified in a western small-footed bat (Myotis ciliolabrum) from the USA and a common pipistrelle bats (Pipistrellus pipistrellus) from the Czech Republic. Two novel genotypes were identified and named Cryptosporidium bat genotype III and IV. Bat genotype III was found in two big brown bats (Eptesicus fuscus) from the USA. Bat genotype IV was detected in two common pipistrelle bats from the Czech Republic.

Intensity-modulated whole abdomen irradiation following adjuvant carboplatin/taxane chemotherapy for FIGO stage III ovarian cancer. Four-year outcomes

Energy Technology Data Exchange (ETDEWEB)

Rochet, Nathalie; Lindel, Katja; Katayama, Sonja; Schubert, Kai; Herfarth, Klaus; Harms, Wolfgang; Debus, Juergen [Heidelberg Institute of Radiation Oncology (HIRO), Heidelberg (Germany); University of Heidelberg, Department of Radiation Oncology, Heidelberg (Germany); Schneeweiss, Andreas [University of Heidelberg, Nationales Centrum fuer Tumorerkrankungen (NCT), Heidelberg (Germany); Sohn, Christoph [University of Heidelberg, Department of Gynecology, Heidelberg (Germany)

2015-07-15

;'intensity-modulated whole-abdominal irradiation'', IM-WAI) nach adjuvanter Chemotherapie beim Ovarialkarzinom im Stadium FIGO III prospektiv untersucht. Zwischen 2006 und 2009 wurden 16 Patientinnen mit optimal reseziertem Ovarialkarzinom im Stadium FIGO III mittels konsolidierender IM-WAI nach 6 Zyklen adjuvanter Carboplatin-/Taxane-Chemotherapie behandelt. Die ersten 10 Patientinnen wurden im Rahmen einer prospektiven Phase-I-Studie behandelt, danach wurden 6 Patientinnen analog zu dem Studienprotokoll behandelt. Bestrahlt wurde bis zu einer Gesamtdosis von 30 Gy in 1,5 Gy Fraktionen mittels ''step-and-shoot'' (n = 3) oder helikaler Tomotherapietechnik (n = 13). Das Zielvolumen umfasste die gesamte Peritonealhoehle, die Zwerchfellkuppeln, die Leberkapsel und die paraaortalen und pelvinen Lymphabflusswege. Risikoorgane waren die Nieren, das Leberparenchym, Herz und Knochen. Das mediane Follow-up betrug 44 Monate (Spanne 19,2-67,2 Monate). Unter Bestrahlung traten keine CTC-Grad-IV-Toxizitaeten auf und es fanden keine toxizitaetsbedingten Unterbrechungen statt. Beobachtete Grad-III-Akuttoxizitaeten waren Diarrhoe (25 %), Leukopenie (19 %), Uebelkeit/Erbrechen (6 %) und Thrombozytopenie (6 %). Insgesamt erlitten 6 Patientinnen einen Darmverschluss im spaeteren Verlauf (37 %). Die Ursachen dafuer waren postoperative Briden (19 %) und Peritonealkarzinose (19 %). Das mediane rezidivfreie Ueberleben (RFS) betrug 27,6 Monate (95 %-KI 24-44 Monate) und das mediane Gesamtueberleben betrug 42,1 Monate (95 %-KI 17-68 Monate). Die Peritonealhoehle war die haeufigste Rezidivstelle. Die konsolidierende IM-WAI ist machbar und klinisch gut vertraeglich. Die Daten zum RFS sind vielversprechend und rechtfertigen die Einleitung weiterer klinischer Studien. (orig.)

La(III) sorption studies on poly(dibenzo-18-crown-6) for the sequential separation of La(III), Th(IV) and U(VI) in L-arginine

International Nuclear Information System (INIS)

Sabale, Sandip; Nikam, Gurunath; Mohite, B.S.

2010-01-01

Poly(dibenzo-18-crown-6) is used as a stationary phase to study the sorption behavior of La(III) in L-arginine medium. The quantitative adsorption of La(III) was found at 1 x 10 -4 to 1 x 10 -6 M L-arginine. 1.0-8.0 M HCl, 0.5-8.0 M HBr and HClO 4 were found to be an efficient eluents for La(III). The capacity of crown polymer for La(III) was found to be 1.37±0.01 mmol/g. The tolerance limit of various cations and anions for La(III) was determined. La(III) was quantitatively separated from other metal ions in binary as well as multicomponent mixtures. The study was extended to sequential separation of La(III), U(VI) and Th(IV). The good separation yields were obtained and have good reproducibility (±2%). The method incorporates the determination of La(III) in real sample. The method is simple, rapid and selective. (author)

Advanced-stage III/IV follicular lymphoma. Treatment strategies for individual patients

Energy Technology Data Exchange (ETDEWEB)

Heinzelmann, Frank; Bamberg, Michael; Weinmann, Martin [Dept. of Radiation Oncology, Univ. of Tuebingen (Germany); Ottinger, Hellmut [Dept. of Bone Marrow Transplantation, Univ. of Essen (Germany); Engelhard, Marianne [Dept. of Radiation Oncology, Univ. of Essen (Germany); Soekler, Martin [Dept. of Internal Medicine II, Univ. of Tuebingen (Germany)

2010-05-15

Background: in patients with advanced-stage III/IV follicular lymphoma (FL), there are many treatment options available. The current challenge is to choose the optimal strategy for the individual patient. Methods: the literature was reviewed with respect to treatment strategies in patients with advanced FL by screening the PubMed databank. Results: in advanced-stage III/IV FL, median survival may approach 8-10 years. Treatment strategies include a watch-and-wait strategy, chemoimmunotherapy, monotherapy with rituximab, and - as an experimental approach so far - radioimmunotherapy. The use of autologous hematopoietic stem cell transplantation (HSCT) for patients in first remission or chemosensitive relapse prolongs progression-free survival while the effect on overall survival remains unclear compared to standard chemotherapy. However, long-term results are flawed by high relapse rates and risk of secondary malignancies. In patients with relapsed/chemoresistant disease, allogeneic HSCT constitutes the only curative approach but is associated with high treatment-related mortality. In the palliative setting, low-dose involved-field irradiation constitutes an effective treatment option in order to control local symptoms with potential long-lasting response. Conclusion: in case of advanced-disease FL, asymptomatic patients can be managed expectantly. In symptomatic patients, chemoimmunotherapy is regarded as standard therapy. In symptomatic elderly patients with relevant comorbidities, rituximab {+-} single-agent chemotherapy, or low-dose involved-field radiotherapy might be appropriate. For younger patients with chemoresistant/relapsed disease, allogeneic HSCT might be considered, since advances in supportive care and better patient selection have resulted in improved outcomes. (orig.)

CHARACTERIZATION OF ORG-20241, A COMBINED PHOSPHODIESTERASE IV/III CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE INHIBITOR FOR ASTHMA

NARCIS (Netherlands)

NICHOLSON, CD; BRUIN, J; BARRON, E; SPIERS, [No Value; DEBOER, J; VANAMSTERDAM, RGM; ZAAGSMA, J; KELLY, JJ; DENT, G; GIEMBYCZ, MA; BARNES, PJ

The pharmacological profile of a novel cyclic nucleotide phosphodiesterase (PDE) inhibitor, Org 20241, has been characterized. The compound selectively inhibits PDE IV (plC(50), 5.2-6.1) and PDE III (plC(50), 4.4-4.6) from animal and human tissues. Org 20241 relaxed preparations of bovine trachea

[Nordosteuropa als Geschichtsregion : Beiträge des III. Internationalen Symposiums zur Deutschen Kultur und Geschichte im Europäischen Nordosten vom 20. - 22. September 2001 in Tallinn (Estland)] / Janet Laidla

Index Scriptorium Estoniae

Laidla, Janet, 1982-

2008-01-01

Arvustus: Nordosteuropa als Geschichtsregion : Beiträge des III. Internationalen Symposiums zur Deutschen Kultur und Geschichte im Europäischen Nordosten vom 20. - 22. September 2001 in Tallinn (Estland). (Helsinki : Aue-Stiftung ; Lübeck : Scmidt-Römhild, 2006)

Preoperative chemoradiotherapy using superselective intraarterial infusion via superficial temporal artery for stage III, IV oral cancer

Energy Technology Data Exchange (ETDEWEB)

Tohnai, Iwai; Shigetomi, Toshio [Nagoya Univ. (Japan). Graduate School of Medicine; Hayashi, Yasushi [Nagoya Second Red Cross Hospital (Japan)] (and others)

2002-03-01

Thirty-eight patients with stage III, IV oral cancer were treated by preoperative chemoradiotherapy using superselective intraarterial infusion via the superficial temporal artery. Radiotherapy (total dose: 40 Gy) and chemotherapy using CBDCA (total dose: 460 mg/m{sup 2}) were performed daily, followed by surgery. Catheter-insertion of 34 patients was done successfully. Four catheter insertions were not done successfully because of the anomaly of the artery such as common trunk of the lingual artery and the facial artery. The clinical effects were CR in 9 patients (26.5%) and PR in 25 (73.5%), and histopathological effects after surgery were grade III, IV in 10 (29.4%), grade IIb in 23 (67.6%), and grade IIa in 2 (5.8%). The 5-year cumulative survival rate was 67.8%. This superselective intra arterial infusion method could be the technique of choice for the treatment of oral cancer. (author)

Preoperative chemoradiotherapy using superselective intraarterial infusion via superficial temporal artery for stage III, IV oral cancer

International Nuclear Information System (INIS)

Tohnai, Iwai; Shigetomi, Toshio

2002-01-01

Thirty-eight patients with stage III, IV oral cancer were treated by preoperative chemoradiotherapy using superselective intraarterial infusion via the superficial temporal artery. Radiotherapy (total dose: 40 Gy) and chemotherapy using CBDCA (total dose: 460 mg/m 2 ) were performed daily, followed by surgery. Catheter-insertion of 34 patients was done successfully. Four catheter insertions were not done successfully because of the anomaly of the artery such as common trunk of the lingual artery and the facial artery. The clinical effects were CR in 9 patients (26.5%) and PR in 25 (73.5%), and histopathological effects after surgery were grade III, IV in 10 (29.4%), grade IIb in 23 (67.6%), and grade IIa in 2 (5.8%). The 5-year cumulative survival rate was 67.8%. This superselective intra arterial infusion method could be the technique of choice for the treatment of oral cancer. (author)

Redoxspeziation von endlagerrelevanten Elementen mit Hilfe von Trennmethoden gekoppelt an ein Massenspektrometer mit induktiv gekoppeltem Plasma

OpenAIRE

Graser, Carl-Heinrich

2015-01-01

Im Rahmen dieser Arbeit wurden Redoxspeziationsanalysen von Eisen, Neptunium und Plutonium per CE-SF-ICP-MS durchgeführt. Durch Optimierung der Trennparameter konnten Trennungen der Pu Oxidationsstufen III bis VI und Trennungen der Np Oxidationsstufen IV bis VI binnen 15 Minuten mit einer Nachweisgrenze von 10-12 M durchgeführt werden. Die Trennung der Fe Oxidationsstufen II und III gelang in weniger als 5 Minuten mit einer Nachweisgrenze von 5-10-8 M.

"Fair Valueu" und die Korperschaftsteuer aus spanischer Sicht - Anmerkungen zur steuerlichen Geeignetheit der IFRS'

OpenAIRE

Báez Moreno, Andrés; Kaiser, Thomas

2007-01-01

1. Problemaufriss; M6glichkeiten der Einbeziehung der IASIIFRS in die Einzelabschlüsse und steuerliche Auswirkungen TI. Vom .Fair Value" betroffene Aktiva und Auswirkung auf das Jahresergebnis 1. Erfolgswirksame Neubewertungen 2. Erfolgsneutrale Neubewertungen III. Die Neubewertung mit dem .Fair Value" und das Problem der Besteuerung nicht realisierter Gewinne1. Das Argument der fehlenden Liquiditiit 2. Das Argument der Bewertungsschwierigkeiten 3. Das Argument der ...

Hepatic Artery Resection for Bismuth Type III and IV Hilar Cholangiocarcinoma: Is Reconstruction Always Required?

Science.gov (United States)

Hu, Hai-Jie; Jin, Yan-Wen; Zhou, Rong-Xing; Shrestha, Anuj; Ma, Wen-Jie; Yang, Qin; Wang, Jun-Ke; Liu, Fei; Cheng, Nan-Sheng; Li, Fu-Yu

2018-03-06

The objective of the study is to examine the feasibility of hepatic artery resection (HAR) without subsequent reconstruction (RCS) in specified patients of Bismuth type III and IV hilar cholangiocarcinoma. We retrospectively reviewed 63 patients who underwent hepatic artery resection for Bismuth type III and IV hilar cholangiocarcinoma. These patients were subsequently enrolled into two groups based on whether the artery reconstruction was conducted. Postoperative morbidity and mortality, and long-term survival outcome were compared between the two groups. There were 29 patients in HAR group and 34 patients in the HAR + RCS group. Patients with hepatic artery reconstruction tended to have longer operative time (545.6 ± 143.1 min vs. 656.3 ± 192.8 min; P = 0.013) and smaller tumor size (3.0 ± 1.1 cm vs. 2.5 ± 0.9 cm; P = 0.036). The R0 resection margin was comparable between the HAR group and HAR + RCS group (86.2 vs. 85.3%; P > 0.05). Twelve patients (41.4%) with 24 complications in HAR group and 13 patients (38.2%) with 25 complications in HAR + RCS group were recorded (P = 0.799). The postoperative hepatic failure rate (13.8 vs. 5.9%) and postoperative mortality rate (3.4% vs. 2.9%) were also comparable between the two groups. In the HAR group, the overall 1-, 3-, and 5-year survival rates were 72, 41, and 19%, respectively; while in the HAR + RCS group, the overall 1-, 3-, and 5-year survival rates were 79, 45, and 25%, respectively (P = 0.928). Hepatic artery resection without reconstruction is also a safe and feasible surgical procedure for highly selected cases of Bismuth type III and IV hilar cholangiocarcinoma.

Multidisciplinary management of very advanced stage III and IV melanoma: Proof-of-principle.

Science.gov (United States)

Gutman, Haim; Ben-Ami, Eytan; Shapira-Frommer, Roni; Schachter, Jacob

2012-08-01

Patients with potentially resectable advanced stage III and IV melanoma are a selected subgroup that gain maximal advantage if treated in a melanoma center. Surgery combined with chemo/chemobiotherapy may yield durable remission and long-term palliation. Thirty-seven non-randomly selected patients underwent systemic therapy with the aim of consolidating treatment by surgery. Data were collected prospectively, and analyzed retrospectively. The median follow-up from diagnosis was 50 (3-307) months and 15 (1-156) months when calculated from the last intervention. Twenty-two males and 15 females, with a median age at diagnosis of 44 (20-71) years, with 13 trunk, 13 extremity, 3 head and neck and 8 unknown primary melanomas were included. There were 17 stage III and 20 stage IV patients with a median Breslow thickness of 3.7 (0.45-26) mm. Chemo/chemobiotherapy achieved 7 clinical complete responses (cCRs), 28 partial responses (PRs) and 2 instances of stable disease. Six of the 7 cCRs were operated on, securing pathological complete response in 5 and PR in one. Four of these five and the PR patient still have no evidence of disease (NED). Twenty-one of 30 PR patients were rendered NED by surgery; 14 of these 21 patients succumbed to melanoma, and one is alive with stable disease. Overall, 11 of 37 patients have not succumbed to melanoma, with a median of 72 (14-156) months survival following the last intervention. Of the eight patients with unknown primary melanomas, five have not succumbed to melanoma, with a median of 89 (30-156) months survival following the last intervention. Patients with marginally resectable stage III and IV melanoma have a significant 30% chance, according to this series, for durable remission if treated by a multidisciplinary team in a melanoma center using induction chemobiotherapy and surgery. Results are more favorable for patients with an unknown primary lesion. In view of the currently approved new effective treatments for melanoma, this

Palliative treatment with radiation-emitting metallic stents in unresectable Bismuth type III or IV hilar cholangiocarcinoma.

Science.gov (United States)

Lu, Jian; Guo, Jin-He; Zhu, Hai-Dong; Zhu, Guang-Yu; Wang, Yong; Zhang, Qi; Chen, Li; Wang, Chao; Pan, Tian-Fan; Teng, Gao-Jun

2017-01-01

The emerging data for stenting in combination with brachytherapy in unresectable hilar cholangiocarcinoma are encouraging. The aim of this study was to evaluate the efficacy and safety of radiation-emitting metallic stents (REMS) for unresectable Bismuth type III or IV hilar cholangiocarcinoma. Consecutive patients who underwent percutaneous placement with REMS or uncovered self-expandable metallic stent (SEMS) for unresectable Bismuth type III or IV hilar cholangiocarcinoma between September 2011 and April 2016 were identified into this retrospective study. Data on patient demographics and overall survival, functional success, stent patency and complications were collected at the authors' hospital. A total of 59 patients were included: 33 (55.9%) in the REMS group and 26 (44.1%) in the SEMS group. The median overall survival was 338 days in the REMS group and 141 days in the SEMS group (philar cholangiocarcinoma, and seems to prolong survival as well as patency of stent in these patients.

Interaction of complexes I, III, and IV within the bovine respirasome by single particle cryoelectron tomography

NARCIS (Netherlands)

Dudkina, Natalya V.; Kudryashev, Mikhail; Stahlberg, Henning; Boekema, Egbert J.

2011-01-01

The respirasome is a multisubunit supercomplex of the respiratory chain in mitochondria. Here we report the 3D reconstruction of the bovine heart respirasome, composed of dimeric complex III and single copies of complex I and IV, at about 2.2-nm resolution, determined by cryoelectron tomography and

Percutaneous intraductal radiofrequency ablation in the management of unresectable Bismuth types III and IV hilar cholangiocarcinoma.

Science.gov (United States)

Wang, Yu; Cui, Wei; Fan, Wenzhe; Zhang, Yingqiang; Yao, Wang; Huang, Kunbo; Li, Jiaping

2016-08-16

To assess the feasibility and safety of percutaneous intraductal radiofrequency ablation (RFA) for unresectable Bismuth types III and IV hilar cholangiocarcinoma. Percutaneous intraductal RFA combined with metal stent placement was successful in all patients without any technical problems; the technical success rate was 100%. Chemotherapy was administered to two patients. After treatment, serum direct bilirubin levels were notably decreased. Six patients died during the follow-up period. Median stent patency from the time of the first RFA and survival from the time of diagnosis were 100 days (95% confidence interval (CI), 85-115 days) and 5.3 months (95% CI, 2.5-8.1 months), respectively. No acute pancreatitis, bile duct bleeding and perforation, bile leakage, or other severe complications occurred. Four cases of procedure-related cholangitis, three cases of postoperative abdominal pain, and five cases of asymptomatic transient increase in serum amylase were observed. One patient who presented with stent blockage 252 days' post-procedure underwent repeat ablation. Between September 2013 and May 2015, nine patients with unresectable Bismuth types III and IV hilar cholangiocarcinoma who were treated with percutaneous intraductal RFA combined with metal stent placement after the percutaneous transhepatic cholangial drainage were included in the retrospective analysis. Procedure-related complications, stent patency, and survival after treatment were investigated. Percutaneous intraductal RFA combined with metal stent placement is a technically safe and feasible therapeutic option for the palliative treatment of unresectable Bismuth types III and IV hilar cholangiocarcinoma. Its long-term efficacy and safety is promising, but needs further study via randomized and prospective trials that include a greater number of patients.

1L Mark-IV Target Design Review

Energy Technology Data Exchange (ETDEWEB)

Koehler, Paul E. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

2017-11-16

This presentation includes General Design Considerations; Current (Mark-III) Lower Tier; Mark-III Upper Tier; Performance Metrics; General Improvements for Material Science; General Improvements for Nuclear Science; Improving FOM for Nuclear Science; General Design Considerations Summary; Design Optimization Studies; Expected Mark-IV Performance: Material Science; Expected Mark-IV Performance: Nuclear Science (Disk); Mark IV Enables Much Wider Range of Nuclear-Science FOM Gains than Mark III; Mark-IV Performance Summary; Rod or Disk? Center or Real FOV?; and Project Cost and Schedule.

Efficient generation of volatile cadmium species using Ti(III) and Ti(IV) and application to determination of cadmium by cold vapor generation inductively coupled plasma mass spectrometry (CVG-ICP-MS)†

Science.gov (United States)

Arslan, Zikri; Yilmaz, Vedat; Rose, LaKeysha

2015-01-01

In this study, a highly efficient chemical vapor generation (CVG) approach is reported for determination of cadmium (Cd). Titanium (III) and titanium (IV) were investigated for the first time as catalytic additives along with thiourea, L-cysteine and potassium cyanide (KCN) for generation of volatile Cd species. Both Ti(III) and Ti(IV) provided the highest enhancement with KCN. The improvement with thiourea was marginal (ca. 2-fold), while L-cysteine enhanced signal slightly only with Ti(III) in H2SO4. Optimum CVG conditions were 4% (v/v) HCl + 0.03 M Ti(III) + 0.16 M KCN and 2% (v/v) HNO3 + 0.03 M Ti(IV) + 0.16 M KCN with a 3% (m/v) NaBH4 solution. The sensitivity was improved about 40-fold with Ti(III) and 35-fold with Ti(IV). A limit of detection (LOD) of 3.2 ng L−1 was achieved with Ti(III) by CVG-ICP-MS. The LOD with Ti(IV) was 6.4 ng L−1 which was limited by the blank signals in Ti(IV) solution. Experimental evidence indicated that Ti(III) and Ti(IV) enhanced Cd vapor generation catalytically; for best efficiency mixing prior to reaction with NaBH4 was critical. The method was highly robust against the effects of transition metal ions. No significant suppression was observed in the presence of Co(II), Cr(III), Cu(II), Fe(III), Mn(II), Ni(II) and Zn(II) up to 1.0 μg mL−1. Among the hydride forming elements, no interference was observed from As(III) and Se(IV) at 0.5 μg mL−1 level. The depressive effects from Pb(II) and Sb(III) were not significant at 0.1 μg mL−1 while those from Bi(III) and Sn(II) were marginal. The procedures were validated with determination of Cd by CVG-ICP-MS in a number certified reference materials, including Nearshore seawater (CASS-4), Bone ash (SRM 1400), Dogfish liver (DOLT-4), Mussel tissue (SRM 2976) and Domestic Sludge (SRM 2781). PMID:26251554

Reactivity of the uranium (U(IV)/U(VI)) and the plutonium (Pu(III)/Pu(IV)) in nitric aqueous solution under ultrasound

International Nuclear Information System (INIS)

Venault, L.

1998-01-01

To minimize the volumes of solid waste and industrial effluents generated at the end of cycle, particularly in the spent nuclear fuel reprocessing industry, research is currently under way on so-called innovative processes, designed to induce chemical reactions without adding reagent to the media. Among these processes, the use of ultrasound can prove advantageous, and the purpose of this study is to assess accurately the potential for its application. In the present context, this work shows that the transmission of an ultrasonic wave in aqueous nitric acid solution leads to: the accumulation of nitrous acid in solution, until a steady-sate concentration is reached; the removal of nitrogen monoxide and nitrogen dioxide in the gas stream. The initial kinetics of the formation of HNO 2 in solution was quantified as a function of the nitric acid concentration and the ultrasound intensity. It was also shown than an excess of nitrous acid in nitric solution decomposes under the effect of ultrasound. It is also possible to accumulate hydrogen peroxide in solution during the ultrasonic irradiation of aqueous nitric acid solutions in the presence of a chemical species N 2 H 5 + , NH 2 SO 3 H...) which reacts rapidly with HNO 2 , preventing the reduction of H 2 O 2 by HNO 2 . The mechanisms of HNO 2 formation and decomposition, and the mechanism of H 2 O 2 formation during the ultrasonic irradiation of aqueous nitric acid solutions, are presented. Control of H 2 O 2 or HNO 2 in a nitric acid medium under the effect of an ultrasonic wave can be exploited to control redox reactions of uranium and plutonium ions, particularly with respect to the oxidation of U and Pu (U(IV)→ U(IV) or Pu(III) → Pu(IV)) and the reduction of Pu (Pu(IV)→ Pu(III). The redox behavior of uranium and plutonium ions in aqueous nitric solution subject to an ultrasonic flux is interpreted in term of effects induced on the reaction medium, and reveals the potential for using ultrasound to cause

Potentiometric Sensor for Gadolinium(III Ion Based on Zirconium(IV Tungstophosphate as an Electroactive Material

Directory of Open Access Journals (Sweden)

Harish K. Sharma

2009-01-01

Full Text Available A new inorganic ion exchanger has been synthesized namely Zirconium(IV tungstophosphate [ZrWP]. The synthesized exchanger was characterized using ion exchange capacity and distribution coefficient (Kd. For further studies, exchanger with 0.35 meq/g ion-exchange capacity was selected. Electrochemical studies were carried out on the ion exchange membranes using epoxy resin as a binder. In case of ZrWP, the membrane having the composition; Zirconium(IV tugstophosphate (40% and epoxy resin (60% exhibits best performance. The membrane works well over a wide range of concentration from 1×10-5 to 1×10-1 M of Gd(III ion with an over- Nernstian slope of 30 mv/ decade. The response time of the sensor is 15 seconds. For this membrane, effect of internal solution has been studied and the electrode was successfully used in partially non-aqueous media too. Fixed interference method and matched potential method has been used for determining selectivity coefficient with respect to alkali, alkaline earth, some transition and rare earth metal ions that are normally present along with Gd(III in its ores. The electrode can be used in the pH range 4.0-10.0 for 10-1 M and 3.0-7.0 for 10-2 M concentration of target ion. These sensors have been used as indicator electrodes in the potentiometric titration of Gd(III ion against EDTA and oxalic acid.

Extraction of U(VI), Th(IV), and La(III) from acidic streams and geological samples using AXAD-16-POPDE polymer

Energy Technology Data Exchange (ETDEWEB)

Prabhakaran, D.; Subramanian, M.S. [Indian Institute of Technology, Department of Chemistry, Chennai 600 036 (India)

2004-10-01

A new chromatographic extraction method has been developed using Amberlite XAD-16 (AXAD-16) resin chemically modified with (3-hydroxyphosphinoyl-2-oxo-propyl)phosphonic acid dibenzyl ester (POPDE). The chemically modified polymer was characterized by {sup 13}C CPMAS and {sup 31}P solid-state NMR, Fourier Transform-NIR-FIR-Raman spectroscopy, CHNPS elemental analysis, and thermogravimetric analysis. Extraction studies performed for U(VI), Th(IV), and La(III) showed good distribution ratio (D) values of approximately 10{sup 3}, even under high acidities (1-4 M). Various physiochemical parameters that influence the quantitative metal ion extraction were optimized by static and dynamic methods. Data obtained from kinetic studies revealed that a time duration of {<=}10 min was sufficient to achieve complete metal ion extraction. Maximum metal sorption capacity values under optimum pH conditions were found to be 1.38, 1.33, and 0.75 mmol g{sup -1} for U(VI), Th(IV), and La(III), respectively. Interference studies performed in the presence of concentrated diverse ions and electrolyte species showed quantitative analyte recovery with lower limits of analyte detection being 10 and 20 ng cm{sup -3} for U(VI) and both Th(IV) and La(III), respectively. Sample breakthrough studies performed on the extraction column showed an enrichment factor value of 330 for U(VI) and 270 for Th(IV) and La(III), respectively. Analyte desorption was effective using 15 cm{sup 3} of 1 M (NH{sub 4}){sub 2}CO{sub 3} with >99.8% analyte recovery. The analytical applicability of the developed resin was tested with synthetic mixtures mimicking nuclear spent fuels, seawater compositions and real water and geological samples. The rsd values of the data obtained were within 5.2%, thereby reflecting the reliability of the developed method. (orig.)

Liquid chromatographic studies on the behaviour of Pu(III), Pu(IV) and Pu(VI) on a RP stationary phase in presence of α-hydroxyisobutyric acid as a chelating agent

Energy Technology Data Exchange (ETDEWEB)

Jaison, P.G.; Kumar, Pranaw; Telmore, Vijay M. [Bhabha Atomic Research Centre, Mumbai (India). Fuel Chemistry Division

2017-06-01

Since plutonium possesses multiple oxidation states which can coexist in solution, a method for the identification of these oxidation states is important to understand its chemical processes. Liquid chromatographic studies were carried out to compare the chromatographic behaviour of different oxidation states of Pu in presence of the eluent, α-hydroxyisobutyric acid (HIBA). The three oxidation states of Pu viz. Pu(III), Pu(IV) and Pu(VI) were separated under optimised conditions. It was seen that the presence of the complexing agent influences the equilibrium of Pu(III)/(IV) as well as Pu(IV)/(VI) systems. Pu(III) to Pu(IV) conversion was found to be enhanced by high pH and concentration of HIBA whereas a relatively low pH and high concentration of HIBA promotes the conversion of Pu(VI) to Pu(IV).

Comparison of Wechsler Memory Scale-Fourth Edition (WMS-IV) and Third Edition (WMS-III) dimensional structures: improved ability to evaluate auditory and visual constructs.

Science.gov (United States)

Hoelzle, James B; Nelson, Nathaniel W; Smith, Clifford A

2011-03-01

Dimensional structures underlying the Wechsler Memory Scale-Fourth Edition (WMS-IV) and Wechsler Memory Scale-Third Edition (WMS-III) were compared to determine whether the revised measure has a more coherent and clinically relevant factor structure. Principal component analyses were conducted in normative samples reported in the respective technical manuals. Empirically supported procedures guided retention of dimensions. An invariant two-dimensional WMS-IV structure reflecting constructs of auditory learning/memory and visual attention/memory (C1 = .97; C2 = .96) is more theoretically coherent than the replicable, heterogeneous WMS-III dimension (C1 = .97). This research suggests that the WMS-IV may have greater utility in identifying lateralized memory dysfunction.

Bajo el signo de Licurgo: el reformismo atávico de Agis IV y Cleómenes III = Under the sign of Lycurgus: the atavistic reformism of Agis IV and Cleomenes III

Directory of Open Access Journals (Sweden)

César Fornis

2016-04-01

Full Text Available En el presente estudio se abordan los intentos de reforma en Esparta por los reyes Agis IV y Cleómenes III, que ambos, con finalidad legitimadora, presentaron como una recuperación atávica del kósmos (orden atribuido al legendario Licurgo, aquel que había formado ciudadanos virtuosos y sobre el que se había asentado el glorioso pasado de la ciudad. Se concluye que sus medidas no atacaron las raíces de los males que corroían la polis lacedemonia ni transformaron de modo significativo las vetustas estructuras sociales, políticas y económicas para adaptarlas a los nuevos tiempos, los del Helenismo.In this paper we analyze the attempts of reform of the Spartan state by the kings Agis IV and Cleomenes III. With legitimizing purpose, they presented them as an atavistic recovery of the kosmos (order ascribed to the legendary Lycurgus, which had formed to the citizens in moral virtues and which had settled the glorious past of the city. We conclude that these measures did not attack the roots of the evils corroding the Lacedaimonian polis or significantly transformed the old social, political and economic structures in order to adapt them to the new times, those of the Hellenism. 

On the line intensity ratios of prominent Si II, Si III, and Si IV multiplets

International Nuclear Information System (INIS)

Djenize, S.; Sreckovic, A.; Bukvic, S.

2010-01-01

Line intensities of singly, doubly and triply ionized silicon (Si II, Si III, and Si IV, respectively) belonging to the prominent higher multiplets, are of interest in laboratory and astrophysical plasma diagnostics. We measured these line intensities in the emission spectra of pulsed helium discharge. The Si II line intensity ratios in the 3s3p 22 D-3s 2 4p 2 P o , 3s 2 3d 2 D-3s 2 4f 2 F o , and 3s 2 4p 2 P o -3s 2 4d 2 D transitions, the Si III line intensity ratios in the 3s3d 3 D-3s4p 3 P o , 3s4p 3 P o -3s4d 3 D, 3s4p 3 P o -3s5s 3 S, 3s4s 3 S-3s4p 3 P o , and 3s4f 3 F o -3s5g 3 G transitions, and the Si IV line intensity ratios in the 4p 2 P o -4d 2 D and 4p 2 P o -5s 2 S transitions were obtained in a helium plasma at an electron temperature of about 17,000 ± 2000 K. Line shapes were recorded using a spectrograph and an ICCD camera as a highly-sensitive detection system. The silicon atoms were evaporated from a Pyrex discharge tube designed for the purpose. They represent impurities in the optically thin helium plasma at the silicon ionic wavelengths investigated. The line intensity ratios obtained were compared with those available in the literature, and with values calculated on the basis of available transition probabilities. The experimental data corresponded well with line intensity ratios calculated using the transition probabilities obtained from a Multi Configuration Hartree-Fock approximation for Si III and Si IV spectra. We recommend corrections of some Si II transition probabilities.

Risiko Video- und Computerspiele? Eine Studie über Video- und Computerspielnutzung und Aggression bei 12- und 16- jährigen Jugendlichen

OpenAIRE

Schiller, Eva-Maria; Strohmeier, Dagmar; Spiel, Christiane

2009-01-01

Video -und Computerspielen ist heutzutage eine beliebte Freizeitaktivität von Kindern und Jugendlichen, besonders von Jungen. Trotz der großen Vielfalt der angebotenen Video- und Computerspiele für Kinder und Jugendliche, konzentriert sich die Forschung vorwiegend auf negative Einflüsse von gewalthaltigen Video- und Computerspielen. Da nicht alle Kinder und Jugendliche ausschließlich gewalthaltige Video- und Computerspiele spielen, betrachten wir diesen Fokus in der Wissenschaft als zu eng ge...

Reactivity of the uranium (U(IV)/U(VI)) and the plutonium (Pu(III)/Pu(IV)) in nitric aqueous solution under ultrasound; De l'influence des ultrasons sur la reactivite de l'uranium (U(IV)/U(VI)) et du plutonium (PU(III)/PU(IV)) en solution aqueuse nitrique

Energy Technology Data Exchange (ETDEWEB)

Venault, L

1998-07-01

To minimize the volumes of solid waste and industrial effluents generated at the end of cycle, particularly in the spent nuclear fuel reprocessing industry, research is currently under way on so-called innovative processes, designed to induce chemical reactions without adding reagent to the media. Among these processes, the use of ultrasound can prove advantageous, and the purpose of this study is to assess accurately the potential for its application. In the present context, this work shows that the transmission of an ultrasonic wave in aqueous nitric acid solution leads to: the accumulation of nitrous acid in solution, until a steady-sate concentration is reached; the removal of nitrogen monoxide and nitrogen dioxide in the gas stream. The initial kinetics of the formation of HNO{sub 2} in solution was quantified as a function of the nitric acid concentration and the ultrasound intensity. It was also shown than an excess of nitrous acid in nitric solution decomposes under the effect of ultrasound. It is also possible to accumulate hydrogen peroxide in solution during the ultrasonic irradiation of aqueous nitric acid solutions in the presence of a chemical species (N{sub 2}H{sub 5}{sup +}, NH{sub 2}SO{sub 3}H...) which reacts rapidly with HNO{sub 2}, preventing the reduction of H{sub 2}O{sub 2} by HNO{sub 2}. The mechanisms of HNO{sub 2} formation and decomposition, and the mechanism of H{sub 2}O{sub 2} formation during the ultrasonic irradiation of aqueous nitric acid solutions, are presented. Control of H{sub 2}O{sub 2} or HNO{sub 2} in a nitric acid medium under the effect of an ultrasonic wave can be exploited to control redox reactions of uranium and plutonium ions, particularly with respect to the oxidation of U and Pu (U(IV){yields} U(IV) or Pu(III) {yields} Pu(IV)) and the reduction of Pu (Pu(IV){yields} Pu(III). The redox behavior of uranium and plutonium ions in aqueous nitric solution subject to an ultrasonic flux is interpreted in term of effects

Untersuchungen zur Farbreaktion von Amilorid, Chlorhexidin und Proguanil mit Hypobromit

OpenAIRE

Huth, Silke

2004-01-01

Bei der Reaktion von Amiloridhydrochlorid (1· HCl) mit Brom in alkalischer Lösung wird ein gelbbraunes Dehydrierungsprodukt erhalten, daß als 3-(3-Amino-1,2,4-oxadiazol-5-yl)-5-chlor-2,6-pyrazindiamin (6) identifiziert werden konnte. Durch Vergleich von Massen- und NMR-Spektren der Verbindung 6 mit Spektren von 1· HCl und Referenzsubstanzen I-III konnte auf die verbindung 6 geschlossen werden. Die Struktur wurde durch eine Röntgenstrukturanalyse abgesichert. Erhitzen von Amiloridhydrochlorid ...

New studies on the synthesis and structural chemistry of polynary lithium and silver transition metal phosphates; Neue Untersuchungen zur Synthese und Strukturchemie von polynaeren Lithium- und Silber-Uebergangsmetallphosphaten

Energy Technology Data Exchange (ETDEWEB)

Mosymow, Emma

2015-09-11

/ P / O (M: Cr, Mn) durchgefuehrt. Hierbei wurden erstmalig die Phosphate LiCr{sup II}{sub 4}(PO{sub 4}){sub 3}, NaCr{sup II}{sub 4}(PO{sub 4}){sub 3}, Li{sub 5}Cr{sup II}{sub 2}Cr{sup III}(PO{sub 4}){sub 4}, monoklines Li{sub 3}Cr{sub 2}(PO{sub 4}){sub 3}, Cr{sup II}{sub 5}Cr{sup III}{sub 2}(P{sub 2}O{sub 7}){sub 4} und LiMn{sup II}{sub 2}P{sub 3}O{sub 10} erhalten. Ueber deren Synthese, kristallographische Charakterisierung sowie deren spektroskopische und magnetische Eigenschaften berichtet die vorliegende Arbeit. Die Gleichgewichtsuntersuchungen im System Li / Cr / P / O fuehrten zur Aufklaerung zahlreicher Phasenbeziehungen. So wurden statt der kristallchemisch naheliegenden Verbindungen ''LiCrPO{sub 4}'' und ''Li{sub 2}CrP{sub 2}O{sub 7}'' die Koexistenzgebiete LiCr{sub 4}(PO{sub 4}){sub 3} / Li{sub 5}Cr{sub 3}(PO{sub 4}){sub 4} / Cr{sub 2}O{sub 3} / CrP und Li{sub 9}Cr{sub 3}(P{sub 2}O{sub 7}){sub 3}(PO{sub 4}){sub 2} / Li{sub 3}Cr{sub 2}(PO{sub 4}){sub 3} / LiCrP{sub 2}O{sub 7} / CrP beobachtet. Im System Li / Mn / P / O wurde ebenfalls die Koexistenz einiger Gleichgewichtsphasen aufgeklaert, wie die von Lithium-orthophosphat und Lithium-mangan(II)-orthophosphat sowie von Lithium-metaphosphat und Mangan(III)-metaphosphat. Im Weiteren wurde das De-interkalationsverhalten von Silber-Mangan-phosphaten mit der Moeglichkeit zur Darstellung metastabiler Phosphate mit Mangan in Oxidationsstufen hoeher als 3+ untersucht. Hierbei wurde das Vierstoffsystem Ag / Mn / P / O mit Mn(II) und Mn(III) naeher betrachtet. Die Reaktionsbedingungen wurden an jene der Experimente in den entsprechenden Lithium enthaltenden Systemen angepasst. Im Rahmen der Gleichgewichtsuntersuchungen wurden zwei neue Pyrophosphate AgMnP{sub 2}O{sub 7} und Ag{sub 1,6}Mn{sub 3}(P{sub 2}O{sub 7}){sub 2} gefunden und charakterisiert.

Imaging of Cranial Nerves III, IV, VI in Congenital Cranial Dysinnervation Disorders.

Science.gov (United States)

Kim, Jae Hyoung; Hwang, Jeong Min

2017-06-01

Congenital cranial dysinnervation disorders are a group of diseases caused by abnormal development of cranial nerve nuclei or their axonal connections, resulting in aberrant innervation of the ocular and facial musculature. Its diagnosis could be facilitated by the development of high resolution thin-section magnetic resonance imaging. The purpose of this review is to describe the method to visualize cranial nerves III, IV, and VI and to present the imaging findings of congenital cranial dysinnervation disorders including congenital oculomotor nerve palsy, congenital trochlear nerve palsy, Duane retraction syndrome, Möbius syndrome, congenital fibrosis of the extraocular muscles, synergistic divergence, and synergistic convergence. © 2017 The Korean Ophthalmological Society.

ABNORMAL TYPE-III COLLAGEN PRODUCED BY AN EXON-17-SKIPPING MUTATION OF THE COL3A1 GENE IN EHLERS-DANLOS SYNDROME TYPE-IV IS NOT INCORPORATED INTO THE EXTRACELLULAR-MATRIX

NARCIS (Netherlands)

CHIODO, AA; SILLENCE, DO; COLE, WG; BATEMAN, JF

1995-01-01

A novel heterozygous mutation of the COL3Al gene that encodes the alpha 1(III) chains of type III collagen was identified in a family with the: acrogeric form of Ehlers-Danlos syndrome type IV (EDS-IV). Cultured dermal fibroblasts produced normal and shortened alpha 1(III) chains. The triple helix

Chemotherapy Toxicity On Quality of Life in Older Patients With Stage I, Stage II, Stage III, or Stage IV Ovarian Epithelial, Primary Peritoneal Cavity, or Fallopian Tube Cancer

Science.gov (United States)

2017-05-03

Stage I Ovarian Cancer; Stage IA Fallopian Tube Cancer; Stage IB Fallopian Tube Cancer; Stage IC Fallopian Tube Cancer; Stage II Ovarian Cancer; Stage IIA Fallopian Tube Cancer; Stage IIB Fallopian Tube Cancer; Stage IIC Fallopian Tube Cancer; Stage III Ovarian Cancer; Stage III Primary Peritoneal Cancer; Stage IIIA Fallopian Tube Cancer; Stage IIIB Fallopian Tube Cancer; Stage IIIC Fallopian Tube Cancer; Stage IV Fallopian Tube Cancer; Stage IV Ovarian Cancer; Stage IV Primary Peritoneal Cancer

Significance of measurement of serum fibrosis markers (HA, LN, P III P, IV C) in patients with pulmonary tuberculosis

International Nuclear Information System (INIS)

Zhou Mingxian

2006-01-01

Objective: To study the clinical significance of determination of serum fibrosis markers in patients with pulmonary tuberculosis. Methods: Serum hyaluronic acid (HA), laminin (LN), procollagen III peptide (P III P) and Type IV collagen (IV C) contents were determined with RIA in 128 patients with pulmonary tuberculosis both before and after treatment as well as in 40 controls. Results: Before treatment, the serum contents of the four markers in the patients were significantly higher than those in the controls (P 0.05). Decreases of the levels in treatment failures were not significant and the levels remained significantly higher than those in controls (P<0.01 or P<0.05). Conclusion: Determination of serum fibrosis markers levels in patients with pulmonary tuberculosis is valuable for early diagnosis as well as for evaluation of the effect of chemotherapy. (authors)

Bone radioisotope scanning: usefulness in the evaluation and observation of patients with breast cancer in clinical stage II, III, IV; Gammagrafia osea: utilidad en la evaluacion y seguimiento de pacientes con cancer de mama en estadio clinico II, III, IV

Energy Technology Data Exchange (ETDEWEB)

Cano P, R A

1996-12-31

The clinical records of 420 patients with diagnosis of breast cancer well documented by the pathological anatomy in clinical stage II, III and IV were reviewed. In each one of them has been done at least a bone scanning during the diagnosis. In 52 cases carried out sericeous dosages of CA 15-3 and in some cases it was necessary to administer Samarium-153 EDTMP as palliative therapy of bone pain. The presence of secondary gamma-graphic focuses was 0/84 cases (0%) in clinical stage II, 54/265 cases (20%) in III and 41/91 cases (45%) in IV. The one focus appeared in 6.7% of the cases. In 7 of the 52 cases that received sericeous dosages of CA 15-3 were detected secondary osseous lesions, and 5 of them presented a marker elevation. The bone scanning has shown in many cases the presence of getters focuses in singular places of skeleton, urinary excretory system or mammary tissue. The gamma rays from Sm-153 allowed us to get some appropriate basal views post-therapy of the secondary lesions. The results show that the great incidence of secondary lesions in the skeleton occurred in cases of stages III and IV unlike other countries. The serial repetition of the radioisotope scanning. The presence of one focus in the skeleton of a patient with a well-known neoplasia makes us to do a careful evaluation of the focus nature. The presence of tracer accumulation in the kidney, ureter and bladder allows us to infer the pathology of excretory system that is the first evidence of its presence in many cases. (author). 71 refs., 7 figs., 6 tabs.

Brush Day & Night Phase III to Phase IV: ensuring that good oral health habits are sustainable.

Science.gov (United States)

Melo, Paulo; Fine, Charlotte; Malone, Sinead; Horn, Virginie

2018-05-01

Over the past 10 years, the FDI-Unilever Brush Day & Night partnership has significantly influenced the life of children worldwide through the implementation of school programmes for oral health education and prevention. This article reports the key facts and outcomes of Phase III of the partnership, and announces the launch of Phase IV. During Phase III, the expert advisors of the Brush Day & Night partnership conducted a longitudinal study to evaluate the impact of the '21 Day' programme in almost 8,000 children in 10 countries. Analysis revealed the effectiveness of the 21 Day programme in sustainably educating children to brush their teeth twice a day, with the greatest impact observed in children aged 7-9 years. With the launch of Phase IV, the Brush Day & Night partnership will continue to deliver its oral health school programme for 7-9 year-old children with a strengthened methodology, including randomized sampling and control groups. The scope of the evaluation will be broadened to include oral health-related quality of life indicators, and monitoring of the oral health knowledge of children's parents/carers. © 2018 FDI World Dental Federation.

Amifostine - a radioprotector in locally advanced head and neck tumors

Energy Technology Data Exchange (ETDEWEB)

Schoenekaes, K.G.; Wagner, W. [Paracelsus-Strahlenklinik, Osnabrueck (Germany); Prott, F.J. [Muenster Univ. (Germany). Inst. fuer Strahlenonkologie

1999-11-01

Purpose: There are some preliminary informations about the beneficial use of amifostine in avoiding side effects in patients with head and neck tumors who underwent radiotherapy. Patients and method: Amifostine was given as daily intravenous application (500 mg) 10 to 15 minutes prior to radiotherapy in 20 patients. The results were compared with another collective of patients which was similar. Results: According to the WHO score mucositis became manifest in 10 patients (Grade I) and 4 patients (Grade II) in the amifostine group vs 9 patients (Grade II), 6 patients (Grade III) and 1 patient (Grade IV) in the control group. Xerostomia has been seen in 15 patients (Grade I) and 5 patients (Grade II) after administration of amifostine. Without the drug 2 patients suffered from xerostomia (Grade I), 8 patients (Grade II) and 8 patients (Grade III), respectively. Administering amifostine had been feasible and non problematic. Only a small rate of toxic side effects like nausea (11%) or emesis (4%) was documented. Conclusions: Amifostine is an effective radioprotector decreasing acute and late side effects in patients with head and neck tumors. (orig.) [German] Zielsetzung: Bisher gibt es nur wenige Informationen ueber den Nutzen von Amifostin bezueglich der Verminderung oder Vermeidung von Nebenwirkungen einer Radiatio bei Patienten mit Tumoren im HNO-Trakt. Patienten und Methode: Amifostin wurde als intravenoese Kurzinfusion mit einer Dosis von 500 mg zehn bis 15 Minuten vor der Bestrahlung bei 20 Patienten appliziert. Die unter Radiatio aufgetretenen Nebenwirkungen wurden nach WHO bzw. nach dem Oral Assessment Guide nach Eilers ausgewertet und mit einem entsprechenden historischen Kollektiv der Klinik verglichen. Ergebnisse: In der Amifostin-Gruppe wurde bei zehn Patienten eine Mukositis Grad I und bei vier Patienten eine Mukositis Grad II nach WHO beobachtet. Grad-III- und Grad-IV-Nebenwirkungen traten nicht auf. In der Kontrollgruppe waren dagegen bei neun

Multisensor system for determination of iron(II), iron(III), uranium(VI) and uranium(IV) in complex solutions

International Nuclear Information System (INIS)

Legin, A.V.; Seleznev, B.L.; Rudnitskaya, A.M.; Vlasov, Yu.G.; Tverdokhlebov, S.V.; Mack, B.; Abraham, A.; Arnold, T.; Baraniak, L.; Nitsche, H.

1999-01-01

Development and analytical evaluation of a multisensor system based on the principles of 'electronic tongue' for the determination of low contents of uranium(VI), uranium(IV), iron(II) and iron(III) in complex aqueous media have been carried out. A set of 29 different chemical sensors on the basis of all- solid-state crystalline and vitreous materials with enhanced electronic conductivity and redox and ionic cross-sensitivity have been incorporated into the sensor array. Multidimensional data have been processed by pattern recognition methods such as artificial neural networks and partial least squares. It has been demonstrated that Fe(II) and Fe(III) contents in the range from 10 -7 to 10 -4 mol L -1 of total iron concentration can be determined with the average precision of about 25 %. U(VI) and U(IV) contents can been determined with the average precision of 10-40% depending on the concentration. The developed multisensor system can be applied in future for the analysis of mining and borehole waters as well other contaminated natural media, including on-site measurements. (author)

Electrochemical investigations of Pu(IV)/Pu(III) redox reaction using graphene modified glassy carbon electrodes and a comparison to the performance of SWCNTs modified glassy carbon electrodes

International Nuclear Information System (INIS)

Gupta, Ruma; Gamare, Jayashree; Sharma, Manoj K.; Kamat, J.V.

2016-01-01

Highlights: • First report of aqueous electrochemistry of Plutonium on graphene modified electrode. • Graphene is best electrocatalytic material for Pu(IV)/Pu(III) redox couple among the reported modifiers viz. reduced graphene oxide (rGO) and SWCNT’s. • The electrochemical reversibility of Pu(IV)/Pu(III) redox couple improves significantly on graphene modified electrode compared to previously reported rGO & SWCNTs modified electrodes • Donnan interaction between plutonium species and graphene surface offers a possibility for designing a highly sensitive sensor for plutonium • Graphene modified electrode shows higher sensitivity for the determination of plutonium compared to glassy carbon and single walled carbon nanotube modified electrode - Abstract: The work reported in this paper demonstrates for the first time that graphene modified glassy carbon electrode (Gr/GC) show remarkable electrocatalysis towards Pu(IV)/Pu(III) redox reaction and the results were compared with that of single-walled carbon nanotubes modified GC (SWCNTs/GC) and glassy carbon (GC) electrodes. Graphene catalyzes the exchange of current of the Pu(IV)/Pu(III) couple by reducing both the anodic and cathodic overpotentials. The Gr/GC electrode shows higher peak currents (i p ) and smaller peak potential separation (ΔE p ) values than the SWCNTs/GC and GC electrodes. The heterogeneous electron transfer rate constants (k s ), charge transfer coefficients (α) and the diffusion coefficients (D) involved in the electrocatalytic redox reaction were determined. Our observations show that graphene is best electrocatalytic material among both the SWCNTs and GC to study Pu(IV)/Pu(III) redox reaction.

Studies on the turnover and properties of dump groundwaters in brown coal mining areas and possibilities of influencing them. Final report; Untersuchungen zum Stoffumsatz und zur Beschaffenheit der Kippengrundwaesser in Braunkohlebergbaugebieten und Moeglichkeiten zu deren Beeinflussung. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Katzur, J.; Liebner, F.; Liebner, C.; Welzel, H.P.; Hettrich, K.

2001-07-01

Only 6 days after the increase in pH with water saturation the concentration of iron in the pore water of the T1 sediment had dropped to a low value, 70% of which was accounted for by Fe(II). This is probably due to the almost complete precipitation of Fe(III) caused by the high pH values. Compared with the untreated variant the lowering of pH in the further course of the experiment led to a slight Fe(III) mobilisation and hence, through interaction with other reduction processes, to erratic changes in the share of Fe(II) in total Fe. Although this sediment showed a relatively low iron concentration a comparison showed that higher pH values and incubation temperatures have an influence on microbial iron reduction. [German] Im Porenwasser des Sedimentes T1 lag Eisen bereits 6 Tage nach pH-Erhoehung und Wassersaettigung nur noch in geringer Konzentration und zu ueber 70% als Fe(II) vor. Dies ist vermutlich in erster Linie auf die nahezu vollstaendige Ausfaellung von Fe(III) infolge der hohen pH-Werte zurueckzufuehren. Im weiteren Versuchsverlauf fuehrte das Absinken der pH-Werte zu einer im Vergleich zur unbehandelten Variante geringfuegigen Fe(III)-Mobilisierung und damit in Wechselwirkung mit ablaufenden Reduktionsprozessen zu unstetigen Veraenderungen in den Anteilen Fe(II) an Fe{sub ges}. Obwohl in diesem Sediment nur vergleichsweise niedrige Eisenkonzentrationen vorliegen, ergab ein Vergleich, dass hoehere pH-Werte und Inkubationtemperaturen die mikrobielle Eisenreduktion beeinflussen. (orig.)

Structural features and electronic properties of group-III-, group-IV-, and group-V-doped Si nanocrystallites

International Nuclear Information System (INIS)

Ramos, L E; Degoli, Elena; Cantele, G; Ossicini, Stefano; Ninno, D; Furthmueller, J; Bechstedt, F

2007-01-01

We investigate the incorporation of group-III (B and Al), group-IV (C and Ge), and group-V (N and P) impurities in Si nanocrystallites. The structural features and electronic properties of doped Si nanocrystallites, which are faceted or spherical-like, are studied by means of an ab initio pseudopotential method including spin polarization. Jahn-Teller distortions occur in the neighborhood of the impurity sites and the bond lengths show a dependence on size and shape of the nanocrystallites. We find that the acceptor (group-III) and donor (group-V) levels become deep as the nanocrystallites become small. The energy difference between the spin-up and spin-down levels of group-III and group-V impurities decreases as the size of the Si nanocrystallite increases and tends to the value calculated for Si bulk. Doping with carbon introduces an impurity-related level in the energy gap of the Si nanocrystallites

Übergewicht und Adipositas in Kindheit und Jugend

OpenAIRE

Nitzko, Sina

2010-01-01

Einführend wird auf wesentliche Entwicklungsaspekte der interessierenden Lebensphasen Kindheit und Jugend eingegangen. Im Anschluss daran werden verschiedene Aspekte von Übergewicht und Adipositas in Kindheit und Jugend thematisiert. Neben der Definition und Diagnostik, wird auf Möglichkeiten der Klassifikation sowie die Epidemiologie eingegangen. Dargestellt werden darüber hinaus körperliche und psychische Folgestörungen, welche mit Adipositas assoziiert sein können. Basierend auf der...

[Clinical value of "Kou mode of hepatic hilar anastomosis" in resection of type III or IV hepatic hilar cholangiocarcinoma].

Science.gov (United States)

He, Xiao-dong; Liu, Wei; Tao, Lian-yuan; Zhang, Zhen-huan; Cai, Lei; Zhang, Shuang-min

2009-08-01

To evaluate the surgical technique of "Kou mode of hepatic hilar anastomosis" in the treatment for type III or IV hilar cholangiocarcinoma. The clinical data of 89 patients with type III or IV hilar cholangiocarcinoma surgically treated in our department between Jan. 1990 and Jan. 2008 were retrospectively analyzed. Since January 2000, "Kou mode of hepatic hilar anastomosis" was performed for some patients with advanced hilar cholangiocarcinoma. The patients were divided into two groups: group A treated between 1990 and 1999, group B between 2000 and 2008. The rate of resection, therapeutic efficacy and complications in these two groups were compared, respectively. Of the 37 cases with hilar cholangiocarcinoma in group A, 4 were surgically treated (10.8%), with 1 (2.7%) radical resection and 3 (8.1%) palliative resection. Among the 52 cases with hilar cholangiocarcinoma in the group B, 35 (67.3%) received surgical resection, of them 15 (28.8%) underwent radical resection and 20 (38.5%) had palliative resection. Twenty-eight of these 35 cases underwent the "Kou mode of hepatic hilar anastomosis". The resection rate of advanced hilar cholangiocarcinoma in the group B was significantly higher than that in group A (P anastomosis" developed bile leakage to a varying degree and recovered after drainage and symptomatic treatment. The resection rate of type III or IV advanced hilar cholangiocarcinoma can be remarkably improved by using a novel alternative surgical technique called "Kou mode of hepatic hilar anastomosis". However, the long-term outcome still needs to be determined by close follow-up and further observation.

Crystal structures of lazulite-type oxidephosphates TiIIITiIV3O3(PO4)3 and MIII4TiIV27O24(PO4)24 (MIII=Ti, Cr, Fe)

International Nuclear Information System (INIS)

Schoeneborn, M.; Glaum, R.; Reinauer, F.

2008-01-01

Single crystals of the oxidephosphates Ti III Ti IV 3 O 3 (PO 4 ) 3 (black), Cr III 4 Ti IV 27 O 24 (PO 4 ) 24 (red-brown, transparent), and Fe III 4 Ti IV 27 O 24 (PO 4 ) 24 (brown) with edge-lengths up to 0.3 mm were grown by chemical vapour transport. The crystal structures of these orthorhombic members (space group F2dd ) of the lazulite/lipscombite structure family were refined from single-crystal data [Ti III Ti IV 3 O 3 (PO 4 ) 3 : Z=24, a=7.3261(9) A, b=22.166(5) A, c=39.239(8) A, R 1 =0.029, wR 2 =0.084, 6055 independent reflections, 301 variables; Cr III 4 Ti IV 27 O 24 (PO 4 ) 24 : Z=1, a=7.419(3) A, b=21.640(5) A, c=13.057(4) A, R 1 =0.037, wR 2 =0.097, 1524 independent reflections, 111 variables; Fe III 4 Ti IV 27 O 24 (PO 4 ) 24 : Z=1, a=7.4001(9) A, b=21.7503(2) A, c=12.775(3) A, R 1 =0.049, wR 2 =0.140, 1240 independent reflections, 112 variables). For Ti III Ti IV O 3 (PO 4 ) 3 a well-ordered structure built from dimers [Ti III,IV 2 O 9 ] and [Ti IV,IV 2 O 9 ] and phosphate tetrahedra is found. The metal sites in the crystal structures of Cr 4 Ti 27 O 24 (PO 4 ) 24 and Fe 4 Ti 27 O 24 (PO 4 ) 24 , consisting of dimers [M III Ti IV O 9 ] and [Ti IV,IV 2 O 9 ], monomeric [Ti IV O 6 ] octahedra, and phosphate tetrahedra, are heavily disordered. Site disorder, leading to partial occupancy of all octahedral voids of the parent lipscombite/lazulite structure, as well as splitting of the metal positions is observed. According to Guinier photographs Ti III 4 Ti IV 27 O 24 (PO 4 ) 24 (a=7.418(2) A, b=21.933(6) A, c=12.948(7) A) is isotypic to the oxidephosphates M III 4 Ti IV 27 O 24 (PO 4 ) 24 (M III : Cr, Fe). The UV/vis spectrum of Cr 4 Ti 27 O 24 (PO 4 ) 24 reveals a rather small ligand-field splitting Δ o =14,370 cm -1 and a very low nephelauxetic ratio β=0.72 for the chromophores [Cr III O 6 ] within the dimers [Cr III Ti IV O 9 ]. - Graphical abstract: Single crystals of the oxidephosphates Ti III Ti IV 3 O 3 (PO 4 ) 3 (black), Cr III 4 Ti IV 27 O

Evaluation of concomitant use of non-specific immunopotentiator on 172 cases of primary lung cancer (Stage III, IV) treated with radiation combined with chemotherapy

International Nuclear Information System (INIS)

Ogawa, Yasuhiro; Kimura, Shuji; Imajo, Yoshinari; Hamada, Fumio; Miyaji, Chihiro

1982-01-01

The clinical effect of concomitant use of non-specific immunopotentiator OK-432 and/or PSK was studied about 172 cases of primary lung cancer (Stage III, IV). In 91 cases in stage III, fifty percent survival period was found to be 11.5 months for 63 cases with OK-432 and/or PSK, and 7.5 months for 28 cases without immunotherapy, respectively. In 81 cases in stage IV, fifty percent survival period was found to be 6.7 months for 45 cases with OK-432 and/or PSK, and 3.3 months for 36 cases without immunotherapy, respectively. (author)

Organic contaminants degradation from the S(IV) autoxidation process catalyzed by ferrous-manganous ions: A noticeable Mn(III) oxidation process.

Science.gov (United States)

Zhang, Jiaming; Ma, Jun; Song, Haoran; Sun, Shaofang; Zhang, Zhongxiang; Yang, Tao

2018-04-15

Remarkable atrazine degradation in the S(IV) autoxidation process catalyzed by Fe 2+ -Mn 2+ (Fe 2+ /Mn 2+ /sulfite) was demonstrated in this study. Competitive kinetic experiments, alcohol inhibiting methods and electron spin resonance (ESR) experiments proved that sulfur radicals were not the major oxidation species. Mn(III) was demonstrated to be the primary active species in the Fe 2+ /Mn 2+ /sulfite process based on the comparison of oxidation selectivity. Moreover, the inhibiting effect of the Mn(III) hydrolysis and the S(IV) autoxidation in the presence of organic contaminants indicated the existence of three Mn(III) consumption routes in the Fe 2+ /Mn 2+ /sulfite process. The absence of hydroxyl radical and sulfate radical was interpreted by the competitive dynamics method. The oxidation capacity of the Fe 2+ /Mn 2+ /sulfite was independent of the initial pH (4.0-6.0) because the fast decay of S(IV) decreased initial pH below 4.0 rapidly. The rate of ATZ degradation was independent of the dissolved oxygen (DO) because that the major DO consumption process was not the rate determining step during the production of SO 5 •- . Phosphate and bicarbonate were confirmed to have greater inhibitory effects than other environmental factors because of their strong pH buffering capacity and complexing capacity for Fe 3+ . The proposed acetylation degradation pathway of ATZ showed the application of the Fe 2+ /Mn 2+ /sulfite process in the research of contaminants degradation pathways. This work investigated the characteristics of the Fe 2+ /Mn 2+ /sulfite process in the presence of organic contaminants, which might promote the development of Mn(III) oxidation technology. Copyright © 2018. Published by Elsevier Ltd.

Liquid-liquid extraction (LLE) of Fe(III) and Ti(IV) by bis-(2-ethyl-hexyl) phosphoric acid (D2EHPA) in sulfuric acid medium; Extracao liquido-liquido de ferro (III) e titanio (IV) pelo acido bis-(2-etil-hexil) fosforico (D2EHPA) em meio de acido sulfurico

Energy Technology Data Exchange (ETDEWEB)

Silva, Glauco Correa da; Cunha, Jose Waldemar Silva Dias da [Instituto de Engenharia Nuclear (IEN), Rio de Janeiro, RJ (Brazil). Dept. de Quimica e Materiais Nucleares; Dweck, Jo [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Escola de Quimica. Dept. de Processos Inorganicos; Afonso, Julio Carlos [Universidade Federal do Rio de Janeiro (UFRJ), RJ (Brazil). Inst. de Quimica. Dept. de Quimica Analitica]. E-mail: julio@iq.ufrj.br

2008-07-01

This work presents a study on the separation of Fe(III) and Ti(IV) from sulfuric acid leaching solutions of ilmenite (FeTiO{sub 3}) using liquid-liquid extraction with D2EHPA in n-dodecane as extracting agent. The distribution coefficients (K{sub D}) of the elements related to free acidity and concentration of Fe(III) and Ti(IV) were determined. Free acidity was changed from 3x10{sup -2} to 11.88 mol L{sup -1} and D2EHPA concentration was fixed at 1.5 mol L{sup 1}. Recovery of final products as well as recycling of wastes generated in the process were also investigated. The LLE process as a feasible alternative to obtain high-purity TiO{sub 2}. (author)

Superselective intra-arterial infusion chemotherapy for stage III/IV squamous cell carcinomas of the oral cavity: Midterm results

International Nuclear Information System (INIS)

Ikushima, I.; Korogi, Y.; Ishii, A.; Hirai, T.; Yamura, M.; Nishimura, R.; Baba, Y.; Yamashita, Y.; Shinohara, M.

2008-01-01

Purpose: We performed superselective intra-arterial infusion chemotherapy (SIC) according to a protocol in which drug distribution is evaluated by the use of interventional radiology (IVR)-computed tomography (CT) system, and the chemotherapy is combined with medium-dose conformal radiation therapy (CRT). We analyzed retrospectively the factors that affect the midterm survival ratio, including local response, for stage III and IV squamous cell carcinomas of the oral cavity. Materials and methods: Forty consecutive patients with stage III and IV squamous cell carcinomas of the oral cavity and who had undergone both SIC and CRT were enrolled. A microcatheter was placed in the appropriate feeding artery of the tumor and cisplatin (50 mg/body) was infused twice. CRT was administered with a dual-energy (4 and 10 MV) linear accelerator. The total and daily doses delivered were 30 and 2.0 Gy, respectively. Histopathologic effects were classified into five grades: grade 0 or 1 was defined as a poor response, and grade II or higher as a good response. Age, sex, stage, local response to treatment, mode of invasion and lymph node metastasis were analyzed, and differences in the midterm survival ratio were assessed. Results: The 3-year survival ratio of the 40 cases was 67%. A good local response (III or IV) was achieved in 75% of the cases. The survival ratio of the good local response group was significantly better than that of the poor response group (p = 0.04). Mode of invasion (p = 0.03) and lymph node metastasis (p = 0.01) were also predictive of survival. In the multivariable analysis of survival, however, no variables including good local response (p = 0.12), were predictive. Conslusion: Our new protocol improved local response, but it did not contribute to the survival ratio

Ellbogen- und Handgelenksendoprothetik beim Rheumatiker - Richtlinien und Rehabilitation

Directory of Open Access Journals (Sweden)

Chochole M

2008-01-01

Full Text Available Die Endoprothetik an Ellbogen und Handgelenk ist seit etwa drei Jahrzehnten etabliert. An beiden Gelenken haben sich einzelne Implantate oder Designs durchgesetzt. Operationstechniken und Nachuntersuchungsergebnisse sind publiziert. Wenig ist jedoch zum Thema Nachbehandlung und Nachsorge veröffentlicht. Diese Arbeit beschäftigt sich detailliert mit der ärztlichen und therapeutischen Betreuung nach Implantation einer Ellbogen- oder Handgelenksendoprothese beim Patienten mit rheumatischer Arthritis unter Aufgliederung in Krankenhausaufenthalt, ambulanter Nachsorge sowie stationärer Rehabilitation. Dabei werden Zeitrahmen, Therapieziele und Behandlungen gesondert angeführt.

Light-induced reduction of rhodium(III) and palladium(II) on titanium dioxide dispersions and the selective photochemical separation and recovery of gold(III), platinum(IV), and rhodium(III) in chloride media

Energy Technology Data Exchange (ETDEWEB)

Borgarello, E.; Serpone, N.; Emo, G.; Harris, R.; Pelizzetti, E.; Minero, C.

1986-12-03

Irradiation of aqueous TiO/sub 2/ dispersions containing palladium(II) or rhodium(III) chloride salts with AM1 simulated sunlight leads to the photoreduction of these metals, which are deposited on the semiconductor particle surface. Oxygen is detrimental to the photoreduction of rhodium(III) but not the photoreduction of palladium(II). However, in both cases the reduction process is most efficient if the solution contains CH/sub 3/OH, which acts to scavenge valence band holes of the illuminated TiO/sub 2/ semiconductor. The selective photoreduction and recovery of precious metals from a dilute solution (as might be found in industrial wastes) have been investigated for a mixture of gold(III), platinum(IV), and rhodium(III) chloride salts as a function of various parameters (pH, presence or absence of O/sub 2/, presence or absence of a hole scavenger, and the concentration of the semiconductor). At pH 0, gold is easily separated from platinum and rhodium. The rate of photoreduction of gold(III) on TiO/sub 2/ is nearly independent of the concentration of the semiconductor, under the experimental conditions employed; the limiting rate is 2.7 x 10/sup -7/ M s/sup -1/. The potential utility of this selective photochemical technique is discussed.

Biodegradation of pharmaceuticals and endocrine disruptors with oxygen, nitrate, manganese (IV), iron (III) and sulfate as electron acceptors

Science.gov (United States)

Schmidt, Natalie; Page, Declan; Tiehm, Andreas

2017-08-01

Biodegradation of pharmaceuticals and endocrine disrupting compounds was examined in long term batch experiments for a period of two and a half years to obtain more insight into the effects of redox conditions. A mix including lipid lowering agents (e.g. clofibric acid, gemfibrozil), analgesics (e.g. diclofenac, naproxen), beta blockers (e.g. atenolol, propranolol), X-ray contrast media (e.g. diatrizoic acid, iomeprol) as well as the antiepileptic carbamazepine and endocrine disruptors (e.g. bisphenol A, 17α-ethinylestradiol) was analyzed in batch tests in the presence of oxygen, nitrate, manganese (IV), iron (III), and sulfate. Out of the 23 selected substances, 14 showed a degradation of > 50% of their initial concentrations under aerobic conditions. The beta blockers propranolol and atenolol and the analgesics pentoxifylline and naproxen showed a removal of > 50% under anaerobic conditions. In particular naproxen proved to be degradable with oxygen and under most anaerobic conditions, i.e. with manganese (IV), iron (III), or sulfate. The natural estrogens estriol, estrone and 17β-estradiol showed complete biodegradation under aerobic and nitrate-reducing conditions, with a temporary increase of estrone during transformation of estriol and 17β-estradiol. Transformation of 17β-estradiol under Fe(III)-reducing conditions resulted in an increase of estriol as well. Concentrations of clofibric acid, carbamazepine, iopamidol and diatrizoic acid, known for their recalcitrance in the environment, remained unchanged.

Editorial: Computerspiele und Videogames in formellen und informellen Bildungskontexten

Directory of Open Access Journals (Sweden)

Johannes Fromme

2008-01-01

Full Text Available Computer- und Videospiele sind heute ein selbstverständlicher Bestandteil der Lebenswelt vieler Kinder und Jugendlicher, aber auch von (jüngeren Erwachsenen, die mit diesen neuen Medien aufgewachsen sind. Lange Zeit haben elektronische Bildschirmspiele allenfalls sporadische Beachtung gefunden. Weder in der Medienforschung oder Medienpädagogik noch in der breiteren Öffentlichkeit waren sie ein Gegenstand von breiterem Interesse.* In den letzten knapp zehn Jahren sind Video- und Computerspiele allerdings zunehmend in den Fokus der Aufmerksamkeit gerückt. Dabei sind in der massenmedial vermittelten Öffentlichkeit vor allem Amokläufe in Schulen in einen direkten Zusammenhang mit den Vorlieben (der Täter für bestimmte Computerspiele gebracht worden. Die auch von prominenten Politikern aufgegriffene These lautete, dass gewalthaltige Spiele wie der First Person Shooter «Counterstrike» ein virtuelles Trainingsprogramm für das Töten und daher als wesentliche Ursache solcher Schulmassaker anzusehen seien. Auf der Basis dieser kausalen Wirkungsannahmen bzw. der unterstellten negativen Lern- und Trainingseffekte werden seither immer wieder Forderungen nach einem Verbot solcher «Killerspiele» oder gar nach der Verbannung aller Bildschirmmedien aus den Kinderzimmern abgeleitet. Neben solcher skandalisierter Thematisierung ist aber zunehmend auch eine nüchterne wissenschaftliche Auseinandersetzung zu konstatieren. So haben sich seit Beginn des neuen Jahrtausends die «digital game studies» als interdisziplinäres Forschungsfeld etabliert. Im Jahr 2000 wurde innerhalb der Gesellschaft für Medienwissenschaft z.B. die AG Games gebildet, die sich zu einem wichtigen deutschsprachigen Forum für die wissenschaftliche Beschäftigung mit Computerspielen entwickelt hat, und im Jahr 2002 entstand die internationale Digital Games Research Association (DiGRA, die im September 2009 ihre vierte grosse Konferenz nach 2003, 2005 und 2007 durchgeführt hat

Electrocatalytic performance of Pu(IV)/Pu(III) redox reaction at graphene modified glassy carbon electrode

International Nuclear Information System (INIS)

Gupta, Ruma; Gamare, J.S.; Kamat, J.V.; Aggarwal, S.K.

2014-01-01

In this paper we explore the analytical perspectives of graphene modified electrode utilising commercially available graphene, which is well characterised, completely free from surfactants and has not been purposely oxidised or treated. We compare and critically contrast the electro-analytical performance of graphene modified glassy carbon electrodes (Gr/GC) with that of unmodified GC electrode towards Pu(IV)/Pu(III) redox reaction, monitoring of which has considerable importance in a plethora of areas where electrochemistry is conveniently and beneficially utilised for determination of nuclear fuels

Nationale und transnationale Vernetzung polnischer Städte und Regionen: Auf dem Weg zu einer nachhaltigen Stadt- und Regionalentwicklung

OpenAIRE

Dorsch, Pamela

2003-01-01

"Die Studie 'Nationale und transnationale Vernetzung polnischer Städte und Regionen - Bedeutung für eine nachhaltige Stadt- und Regionalentwicklung' liefert einen Überblick über die Einbindung polnischer Kommunen und Wojewodschaften in allgemeine und politikfeldspezifische Netzwerke auf nationaler und transnationaler Ebene. Besondere Berücksichtigung findet hierbei die Vernetzung in Fragen von Nachhaltigkeit und des Umweltschutzes. Einführend zeigt die Studie den Prozess zunehmender Dezentral...

[Kombinierte Anwendung von Strahlentherapie und adjuvanter Therapie mit einem Mistelextrakt (Viscum album L.) zur Behandlung des oralen malignen Melanoms beim Hund: Eine retrospektive Studie].

Science.gov (United States)

von Bodungen, Uta; Ruess, Katja; Reif, Marcus; Biegel, Ulrike

2017-01-01

Hintergrund: Orale maligne Melanome (OMM) des Hundes zeichnen sich durch schnelles Wachstum, lokale Invasion und hohe Metastasierungsraten aus. Extrakte auf Basis von Viscum album L. (VAE) werden zunehmend in der Krebstherapie sowohl in der Human- als auch in der Veterinärmedizin eingesetzt. Ziel unserer Studie war es zu untersuchen, inwieweit die adjuvante Therapie mit VAE eine therapeutische Option zur Behandlung von OMM ist. Besonderes Augenmerk galt dabei der Überlebenszeit und möglichen Nebenwirkungen. Tiere und Methoden: 26 Hunde mit OMM, die in einem der größten veterinäronkologischen Zentren der Schweiz allesamt eine Strahlentherapie erhielten (teilweise nach operativer Tumorresektion) wurden in die retrospektive Studie eingeschlossen: 18 Hunde wurden mit VAE behandelt (1 ml VAE (Iscador®) in ansteigenden Konzentrationen von 0,1 bis 20 mg/ml subkutan 3-mal pro Woche (VAE-Gruppe), 8 erhielten keine adjuvante Behandlung (Vergleichsgruppe). Wir verglichen die Größenentwicklung der OMM sowie die Überlebenszeit. Ergebnisse: Patienten mit Bestrahlung und adjuvanter VAE-Therapie zeigten mit 236 Tagen eine signifikant längere mediane Überlebenszeit im Vergleich zu Patienten mit Bestrahlung, aber ohne adjuvante VAE-Therapie (49 Tage; Log-Rank-Test: p = 0,0047). Die VAE-Therapie verlängerte die Überlebenszeit um mehr als zwei Drittel (Hazard Ratio (HR) = 0,30, 95%-Konfidenzintervall (KI) 0,11-0,86; p = 0,024), während ein höheres Tumorstadium gemäß UICC (Union internationale contre le cancer) einen statistischen Trend zur Verdopplung des Sterberisikos zeigte (UICC-Stadium III/IV vs. I/II: HR = 2,12, 95%-KI 0,88-5,12; p = 0,095). Zwei Patienten zeigten milde Nebenwirkungen während der VAE-Behandlung. Einer der beiden zeigte 1 Tag lang ein selbstlimitiertes Fieber, bei dem anderen Patienten reduzierten wir die Dosis von einem konzentrierteren zu einem weniger konzentrierten VAE (Serie 0) aufgrund von Müdigkeit, die daraufhin verschwand

Solution chemistry of Mo(III) and Mo(IV): Thermodynamic foundation for modeling localized corrosion

International Nuclear Information System (INIS)

Wang Peiming; Wilson, Leslie L.; Wesolowski, David J.; Rosenqvist, Joergen; Anderko, Andrzej

2010-01-01

To investigate the behavior of molybdenum dissolution products in systems that approximate localized corrosion environments, solubility of Mo(III) in equilibrium with solid MoO 2 has been determined at 80 deg. C as a function of solution acidity, chloride concentration and partial pressure of hydrogen. The measurements indicate a strong increase in solubility with acidity and chloride concentration and a weak effect of hydrogen partial pressure. The obtained results have been combined with literature data for systems containing Mo(III), Mo(IV), and Mo(VI) in solutions to develop a comprehensive thermodynamic model of aqueous molybdenum chemistry. The model is based on a previously developed framework for simulating the properties of electrolyte systems ranging from infinite dilution to solid saturation or fused salt limit. To reproduce the measurements, the model assumes the presence of a chloride complex of Mo(III) (i.e., MoCl 2+ ) and hydrolyzed species (MoOH 2+ , Mo(OH) 2 + , and Mo(OH) 3 0 ) in addition to the Mo 3+ ion. The model generally reproduces the experimental data within experimental scattering and provides a tool for predicting the phase behavior and speciation in complex, concentrated aqueous solutions. Thus, it provides a foundation for simulating the behavior of molybdenum species in localized corrosion environments.

E-Government und E-Banking: Aktueller Stand, Evaluation und Erfolgsfaktoren

OpenAIRE

Bayer, Tobias

2002-01-01

Zu Max Webers Zeiten entsprach die Bürokratie noch ganz dem Vorbild des preussischen Militärs " klare Hierarchien und klare Aufgabenbereiche schlugen sich nieder in Effizienz und Effektivität. Heute ist das Bild getrübt und Worte wie "Erstarrung", "Überreglementierung" und "Verwaltungskultur" machen die Runde. Neben den gestiegenen Erwartungen der Bürger, die sich in Zeiten des E-Banking und E-Commerce nicht mehr in lange Warteschlangen einreihen wollen und auf die rigiden Öffnungszeiten der ...

DSM-IV: a nosology sold before its time?

Science.gov (United States)

Zimmerman, M; Jampala, V C; Sierles, F S; Taylor, M A

1991-04-01

The purpose of this study was to determine whether American psychiatrists believe that DSM-IV is being published too soon after DSM-III-R. The authors conducted a mail survey of the attitudes of practicing psychiatrists (N = 454), residency program directors (N = 128), residents (N = 1,331), and researchers (N = 196) toward the scheduled publication of DSM-IV in the early 1990s. They found that the majority of all four groups believed that DSM-IV is being published prematurely. In contrast to respondents who believed that the timing of DSM-IV is appropriate, those who indicated that it is being published too soon had more recently completed their residency training and also believed that DSM-III-R was published prematurely. There was no association between the psychiatrists' responses and their theoretical orientation, Board certification status, ownership of the DSM manuals, the length of time they had used DSM-III, and the diagnostic manual (DSM-III or DSM-III-R) they were currently using. The belief that DSM-IV is being published too soon could contribute to underuse of DSM-IV by substantial numbers of psychiatrists. Thus, to foster compliance with it, APA must preserve in its efforts to demonstrate that the advantages of publishing it in 1993 outweigh the disadvantages of adopting yet another manual.

The extracellular matrix of Gadus morhua muscle contains types III, V, VI and IV collagens in addition to type I

DEFF Research Database (Denmark)

Brüggemann, Dagmar Adeline; Lawson, M.A.

2005-01-01

Confocal microscopy and immuno‐histochemistry were used to examine collagens in the extracellular matrix of cod Gadus morhua swimming muscle. In addition to the well known presence of type I fibrous collagen, types III and VI were also found in the myocommata and the endomysium. The beaded collagen......, type VI, was found in the endomysium and the network forming collagen, type IV, was found in the basement membrane. This is the first report of type V collagen in cod muscle and of types II, IV and VI in the muscle of a teleost....

Annotated bibliography for liquid metal surface tensions of groups III-A, IV-A, and V-A metals

International Nuclear Information System (INIS)

Murtha, M.J.; Burnet, G.

1976-04-01

An annotated bibliography has been prepared which includes summaries of 82 publications dating from 1920 and dealing with the measurement of the surface tensions of Groups III-A, IV-A, and V-A metals in the liquid state. The bibliography is organized by key element investigated, and contains a tabulation of correlations for surface tension as a function of temperature. A brief discussion dealing with variables and methods has been included

Electrochemical studies of plutonium(IV) complexes in aqueous nitrate solutions

International Nuclear Information System (INIS)

Kim, Seong-Yun; Asakura, Toshihide; Morita, Yasuji

2005-01-01

Electrochemistry has been used to investigate the behavior of plutonium (IV) in 1-7 M HNO 3 solutions. These Pu(IV) complexes were found to be reduced quasi-reversibly to Pu(III) species. The formal redox potentials (E 0 ) for Pu(IV)/Pu(III) couples were determined to be +0.721, +0.712, +0.706, +0.705, +0.704, 0.694, and +0.696 V (vs. Ag/AgCl(SSE)) for Pu(IV) complexes in 1, 2, 3, 4, 5, 6, 7 M HNO 3 solutions, respectively. These results indicate that the reduction product of Pu(IV) is Pu(III), which is considerably stable in HNO 3 solution. (author)

Image-guided radiofrequency ablation of Bosniak category III or IV cystic renal tumors: initial clinical experience

Energy Technology Data Exchange (ETDEWEB)

Park, Byung Kwan; Kim, Chan Kyo [Sungkyunkwan University School of Medicine, Department of Radiology and Center for Imaging Science, Samsung Medical Center, Seoul (Korea); Lee, Hyun Moo [Sungkyunkwan University School of Medicine, Department of Urology, Samsung Medical Center, Seoul (Korea)

2008-07-15

The purpose of this study was to assess the efficacy of image-guided radiofrequency (RF) ablation of cystic renal tumors. Between November 2005 and August 2007, computed tomography (CT) or ultrasound-guided RF ablation was performed in nine patients with 14 Bosniak category III (n = 5) or IV (n = 9) cystic renal tumors using an internally cooled RF ablation system. We evaluated the number of sessions, cycles and duration of energy application, treatment results, lesion size change, and complications. Together the cystic renal tumors required 15 sessions and 23 cycles of energy application. The duration of energy application per one tumor ablation ranged from 1 to 12 min (mean 6 min). The last follow-up CT indicated complete coagulation of 14/14 (100%) lesions. None of these tumors had recurred within 1-19 months (mean 8 months). The maximum diameter of the cystic renal tumors was significantly reduced from 2.5 {+-} 0.6 cm before ablation to 1.7 {+-} 0.7 cm at the last follow-up CT (P < 0.01). Complications were pneumothorax (n = 2), inguinal paresthesia (n = 1), and arteriovenous fistula (n = 1). Image-guided RF ablation is an effective treatment for Bosniak category III or IV cystic renal tumors, which might need relatively shorter duration of energy application than purely solid renal tumors of the same size. (orig.)

Image-guided radiofrequency ablation of Bosniak category III or IV cystic renal tumors: initial clinical experience

International Nuclear Information System (INIS)

Park, Byung Kwan; Kim, Chan Kyo; Lee, Hyun Moo

2008-01-01

The purpose of this study was to assess the efficacy of image-guided radiofrequency (RF) ablation of cystic renal tumors. Between November 2005 and August 2007, computed tomography (CT) or ultrasound-guided RF ablation was performed in nine patients with 14 Bosniak category III (n = 5) or IV (n = 9) cystic renal tumors using an internally cooled RF ablation system. We evaluated the number of sessions, cycles and duration of energy application, treatment results, lesion size change, and complications. Together the cystic renal tumors required 15 sessions and 23 cycles of energy application. The duration of energy application per one tumor ablation ranged from 1 to 12 min (mean 6 min). The last follow-up CT indicated complete coagulation of 14/14 (100%) lesions. None of these tumors had recurred within 1-19 months (mean 8 months). The maximum diameter of the cystic renal tumors was significantly reduced from 2.5 ± 0.6 cm before ablation to 1.7 ± 0.7 cm at the last follow-up CT (P < 0.01). Complications were pneumothorax (n = 2), inguinal paresthesia (n = 1), and arteriovenous fistula (n = 1). Image-guided RF ablation is an effective treatment for Bosniak category III or IV cystic renal tumors, which might need relatively shorter duration of energy application than purely solid renal tumors of the same size. (orig.)

Siloxides as supporting ligands in uranium(III)-mediated small-molecule activation

Energy Technology Data Exchange (ETDEWEB)

Mougel, Victor; Camp, Clement; Pecaut, Jacques; Mazzanti, Marinella [CEA-Grenoble (France). Lab. de Reconnaissance Ionique et Chimie de Coordination; Coperet, Christophe [ETH Zuerich (Switzerland). Lab. of Inorganic Chemistry; Maron, Laurent; Kefalidis, Christos E. [Toulouse Univ. (France). LPCNO, CNRS et INSA, UPS

2012-12-03

Siloxides support the reduction of small molecules with uranium complexes. The treatment of [U{N(SiMe_3)_2}{sub 3}] with HOSi(OtBu){sub 3} (3 equiv.) yielded a novel homoleptic uranium(III) siloxide complex 1, which acted as a two-electron reducing agent toward CS{sub 2} and CO{sub 2}. Uranium(III) siloxide complex 1 also reduced toluene to afford a diuranium inverted-sandwich complex. [German] Siloxide unterstuetzen die Reduktion kleiner Molekuele durch Uran-Komplexe. Die Behandlung von [U{N(SiMe_3)_2}{sub 3}] mit HOSi(OtBu){sub 3} (3 Aequiv.) liefert den neuartigen homoleptischen Uran(III)-Siloxid-Komplex 1, der als Zwei-Elektronen-Reduktionsmittel fuer CS{sub 2} und CO{sub 2} (siehe Schema) wirkt. Komplex 1 reduziert ausserdem Toluol und bildet einen invertierten Diuran-Sandwichkomplex.

Sorption und Verbreitung per- und polyfluorierter Chemikalien (PFAS) in Wasser und Boden

OpenAIRE

Gellrich, Vanessa

2014-01-01

PFAS (= Perfluoroalkyl and Polyfluoroalkyl Substances) sind persistente organische Spurenstoffe, die weltweit in verschiedenen Umweltkompartimenten nachgewiesen werden konnten. Im Rahmen dieser Dissertation sollte die Frage geklärt werden, wie die physikalisch-chemischen Eigenschaften der PFAS - besonders ihre Sorption am Boden - ihr Verhalten und ihre Verbreitung in der Umwelt beeinflussen. Dazu wurde zunächst eine Messmethode entwickelt, optimiert und validiert, mit der 17 per- und polyf...

Use of Fe(III) oxalate for oxidativewastewater treatment; Einsatz von Fe(III)-Oxalat zur chemisch-oxidativen Abwasserbehandlung

Energy Technology Data Exchange (ETDEWEB)

Kim, S.M.; Vogelpohl, A. [Clausthal Univ., Clausthal-Zellerfeld (Germany). Inst. fuer Thermische Verfahrenstechnik

1998-08-01

Iron(III)-oxalate was used as an iron catalyst for the Photo Fenton reaction. Iron(III) oxalations ([Fe(C{sub 2}O{sub 4}){sub 3}]{sup 3-}) are reduced to Fe(II) by irradiation using near UV-light ({lambda} = 300 - 400 nm) or visible light ({lambda} > 400 nm). At the same time, CO{sub 2}{sup -} or C{sub 2}O{sub 4}{sup -}-radicals originate, which cause the secondary reduction of Fe(III) to Fe(II). By means of the photolytically regenerated Fe(II) ions, hydroxyl radicals are increasingly formed, so that the degradation of organic substances is accelerated. The work aimed to assess the catalytic effect of Fe(III) oxalate for photochemical oxidation processes and to establish the parameters influencing further treatment of leachate from a municipal waste sanitary landfill by means of technical-scale experiments. (orig.) [Deutsch] In der vorliegenden Arbeit wurde Eisen(III)-Oxalat als Eisenkatalysator fuer die Photo-Fenton-Reaktion eingesetzt. Eisen(III)-Oxalationen ([Fe(C{sub 2}O{sub 4}){sub 3}]{sup 3-}) werden durch Strahlung mit nahem UV-Licht ({lambda}=300 bis 400 nm) oder mit sichtbarem Licht ({lambda}>400 nm) zu Fe(II) reduziert. Gleichzeitig entstehen CO{sub 2}{sup .-} oder C{sub 2}O{sub 4}{sup .-}-Radikale, die eine sekundaere Reduktion von Fe(III) zu Fe(II) bewirken. Mit Hilfe der photolytiisch regenerierten Fe(II)-Ionen werden vermehrt Hydroxylradikale gebildet und damit die Abbaugeschwindigkeit der organischen Substanzen beschleunigt. Ziel der hier vorgestellten Arbeit war es, die katalytische Wirkung von Fe(III)-Oxalat fuer photochemische Oxidationsverfahren abzuschaetzen und die Einflussparameter zur weitergehenden Behandlung eines Deponiesickerwassers aus Hausmuelldeponie anhand von Technikumsversuchen zu ermitteln. (orig.)

Neue Laser und Strahlquellen - alte und neue Risiken?

DEFF Research Database (Denmark)

Paasch, Uwe; Schwandt, Antje; Seeber, Nikolaus

2017-01-01

Die Entwicklungen im Bereich dermatologischer Laser, hochenergetischer Blitzlampen, LED und neuer Energie- und Strahlquellen der letzten Jahre haben gezeigt, dass mit neuen Wellenlängen, Konzepten und Kombinationen zusätzliche, zum Teil über den ästhetischen Bereich hinaus gehende therapeutische ...

Neue Shandite und Parkerite. Darstellung und röntgenographische Charakterisierung

OpenAIRE

Anusca, Irina

2009-01-01

Das Ziel dieser Arbeit war es, neue Verbindungen mit Shandit- und Parkeritstruktur zu darstellen und mittels röntgenographischen Methoden (Pulverdiffraktometrie und Einkristallanalyse), das thermische Verhalten durch DTA / DSC - Messungen und Elektronenmikroskopische Untersuchungen (REM, EDX) zu charakterisieren. Die vorliegende Arbeit ist wie folgt im zwei Themen gegliedert: Shandite und Parkerite. Der ersten Teil dieser Arbeit befaßt sich mit metallreichen ternären Chalkogeniden M3A2X2, ...

Phosphorylation of ERK in neurokinin 1 receptor-expressing neurons in laminae III and IV of the rat spinal dorsal horn following noxious stimulation

Directory of Open Access Journals (Sweden)

Watanabe Masahiko

2007-02-01

Full Text Available Abstract Background There is a population of large neurons with cell bodies in laminae III and IV of the spinal dorsal horn which express the neurokinin 1 receptor (NK1r and have dendrites that enter the superficial laminae. Although it has been shown that these are all projection neurons and that they are innervated by substance P-containing (nociceptive primary afferents, we know little about their responses to noxious stimuli. In this study we have looked for phosphorylation of extracellular signal-regulated kinases (ERKs in these neurons in response to different types of noxious stimulus applied to one hindlimb of anaesthetised rats. The stimuli were mechanical (repeated pinching, thermal (immersion in water at 52°C or chemical (injection of 2% formaldehyde. Results Five minutes after each type of stimulus we observed numerous cells with phosphorylated ERK (pERK in laminae I and IIo, together with scattered positive cells in deeper laminae. We found that virtually all of the lamina III/IV NK1r-immunoreactive neurons contained pERK after each of these stimuli and that in the great majority of cases there was internalisation of the NK1r on the dorsal dendrites of these cells. In addition, we also saw neurons in lamina III that were pERK-positive but lacked the NK1r, and these were particularly evident in animals that had had the pinch stimulus. Conclusion Our results demonstrate that lamina III/IV NK1r-immunoreactive neurons show receptor internalisation and ERK phosphorylation after mechanical, thermal or chemical noxious stimuli.

The role of Ce(III) in BZ oscillating reactions

Science.gov (United States)

Nogueira, Paulo A.; Varela, Hamilton; Faria, Roberto B.

2012-03-01

Herein we present results on the oscillatory dynamics in the bromate-oxalic acid-acetone-Ce(III)/Ce(IV) system in batch and also in a CSTR. We show that Ce(III) is the necessary reactant to allow the emergence of oscillations. In batch, oscillations occur with Ce(III) and also with Ce(IV), but no induction period is observed with Ce(III). In a CSTR, no oscillations were found using a freshly prepared Ce(IV), but only when the cerium-containing solution was aged, allowing partial conversion of Ce(IV) to Ce(III) by reaction with acetone.

Syntheses and characterization of one-dimensional alkali metal antimony(III) thiostannates(IV), A{sub 2}Sb{sub 2}Sn{sub 3}S{sub 10} (A=K, Rb, Cs)

Energy Technology Data Exchange (ETDEWEB)

Yohannan, Jinu P.; Vidyasagar, Kanamaluru, E-mail: kvsagar@iitm.ac.in

2015-01-15

Three new isostructural quaternary antimony(III) thiostannates(IV), A{sub 2}Sb{sub 2}Sn{sub 3}S{sub 10} (A=K, Rb, Cs) have been synthesized by using alkali metal thiosulfate flux and structurally characterized by X-ray diffraction. Their structures contain A{sup +} ions around the [Sb{sub 2}Sn{sub 3}S{sub 10}]{sup 2−} chains, which are built from SbS{sub 3} pyramids, SnS{sub 6} octahedra and SnS{sub 4} tetrahedra. Raman and Mössbauer spectroscopic measurements corroborate the oxidation states and coordination environments of Sb(III) and Sn(IV). All three compounds are wide band gap semiconductors. Potassium compound undergoes partial exchange with strontium, cadmium and lead ions. - Graphical abstract: Syntheses, crystal structure, spectroscopic and partial ion-exchange studies of new one-dimensional alkali metal antimony(III) thiostannates(IV), A{sub 2}Sb{sub 2}Sn{sub 3}S{sub 10} (A=K, Rb, Cs) are described. - Highlights: • Syntheses of new alkali metal antimony(III) thiostannates(IV), A{sub 2}Sb{sub 2}Sn{sub 3}S{sub 10} (A=K, Rb, Cs). • Wide band gap semiconductors with one-dimensional structure. • Topotactic partial exchange of K{sup +} ions of K{sub 2}Sb{sub 2}Sn{sub 3}S{sub 10} with Sr{sup 2+}, Cd{sup 2+} and Pb{sup 2+} ions.

Zoophilie in Zoologie und Roman: Sex und Liebe zwischen Mensch und Tier bei Plutarch, Plinius dem Älteren, Aelian und Apuleius

Directory of Open Access Journals (Sweden)

Judith Hindermann

2011-09-01

Full Text Available Die Bedeutung von Zoophilie in der antiken Literatur wurde bislang – mit Ausnahme des Mythos – kaum untersucht. Überblickt man die überlieferten literarischen Texte, fällt auf, dass Zoophilie ausserhalb des Mythos vor allem in zwei literarischen Gattungen auftritt : Einerseits in den zoologischen Schriften von Plutarch, Plinius dem Älteren und Aelian, andererseits im antiken Roman, d.h. in den Metamorphosen des Apuleius und im pseudo-lukianischen Onos. In diesem Beitrag soll untersucht werden, welche Funktion Zoophilie in den beiden literarischen Gattungen hat und wie die Autoren die sexuelle Praktik bewerten, die weder nach griechischem noch römischen Recht strafbar war. Da Vorstellungen über Tiere eng mit Gender und Geschlechterhierarchien verbunden sind, soll insbesondere die Frage berücksichtigt werden, inwiefern männliche und weibliche Verhaltens- und Rollenzuschreibungen bei der Darstellung zoophiler Akte wirksam werden.

Die biene und ihre produkte in der kunst und im alltagsleben (Fruhchristliche und byzantinische Zeit

Directory of Open Access Journals (Sweden)

Liveri Angeliki

2010-01-01

Full Text Available Die vorliegende Arbeit ist in zwei Teile geteilt: den kunst- und kulturhistorischen Teil. Im ersten Teil werden Darstellungen uber Bienen Bienenzucht, Honig und Wachs seit der fruhchristlichen bis zur spatbyzantinischen Zeit vorgefuhrt. Daher ist es als Beitrag in der "Ikonographie" der Biene wahrend dieser Zeit zu verstehen. Im kulturhistorischen Teil werden Informationen uber die Bienenzucht, den Handel mit Honig und Wachs sowie ihre vielfaltige Anwendung von der byzantinischen Gesellschaft an Hand der primaren Quellen, des Standes der Forschung und der archaologischen Funden erwahnt. Damit ist erwunscht ein moglichst gutes Bild der byzantinischen Bienenzucht wieder zu geben und die Nutzung der Bienenprodukte in Byzanz anschaulich zu machen.

Bone radioisotope scanning: usefulness in the evaluation and observation of patients with breast cancer in clinical stage II, III, IV

International Nuclear Information System (INIS)

Cano P, R.A.

1995-01-01

The clinical records of 420 patients with diagnosis of breast cancer well documented by the pathological anatomy in clinical stage II, III and IV were reviewed. In each one of them has been done at least a bone scanning during the diagnosis. In 52 cases carried out sericeous dosages of CA 15-3 and in some cases it was necessary to administer Samarium-153 EDTMP as palliative therapy of bone pain. The presence of secondary gamma-graphic focuses was 0/84 cases (0%) in clinical stage II, 54/265 cases (20%) in III and 41/91 cases (45%) in IV. The one focus appeared in 6.7% of the cases. In 7 of the 52 cases that received sericeous dosages of CA 15-3 were detected secondary osseous lesions, and 5 of them presented a marker elevation. The bone scanning has shown in many cases the presence of getters focuses in singular places of skeleton, urinary excretory system or mammary tissue. The gamma rays from Sm-153 allowed us to get some appropriate basal views post-therapy of the secondary lesions. The results show that the great incidence of secondary lesions in the skeleton occurred in cases of stages III and IV unlike other countries. The serial repetition of the radioisotope scanning. The presence of one focus in the skeleton of a patient with a well-known neoplasia makes us to do a careful evaluation of the focus nature. The presence of tracer accumulation in the kidney, ureter and bladder allows us to infer the pathology of excretory system that is the first evidence of its presence in many cases. (author). 71 refs., 7 figs., 6 tabs

Immunohistochemical expression of mitochondrial membrane complexes (MMCs) I, III, IV and V in malignant and benign periampullary epithelium: a potential target for drug therapy of periampullary cancer?

International Nuclear Information System (INIS)

Aloysius, Mark M; Zaitoun, Abed M; Bates, Timothy E; Ilyas, Mohammad; Constantin-Teodosiu, Dumitru; Rowlands, Brian J; Lobo, Dileep N

2010-01-01

Mitochondrial membrane complexes (MMCs) are key mediators of cellular oxidative phosphorylation, and inhibiting them could lead to cell death. No published data are available on the relative abundance of MMCs in different periampullary cancers. Therefore, we studied the expression profile of MMCs I, III, IV and V in periampullary cancers, reactive pancreatitis, normal pancreas and chronic pancreatitis. This was a retrospective study on tissue microarrays constructed from formalin-fixed paraffin-embedded tissue from 126 consecutive patients (cancer = 104, chronic pancreatitis = 22) undergoing pancreatic resections between June 2001 and June 2006. 78 specimens of chronic pancreatitis tissue were obtained adjacent to areas of cancer. Normal pancreatic tissue was obtained from the resection specimens in a total of 30 patients. Metastatic tumours in 61 regional lymph nodes from 61 patients were also studied. MMCs I, III, IV and V were highly expressed (p < 0.05) in all primary periampullary cancers compared with metastatic lymph nodes and adjacent benign pancreas. MMCs III, IV and V were highly expressed in all cancers regardless of type compared with chronic pancreatitis (p < 0.05). Higher expression of MMCs I and V was associated with better survival and may, in part, relate to lower expression of these MMCs in poorly differentiated tumours compared with well and moderately differentiated tumours. Differential expression of MMCs III, IV and V in primary periampullary cancers compared with adjacent benign periampullary tissue and chronic pancreatitis is a novel finding, which may render them attractive anticancer targets

Vom Stabilitäts- und Wachstumsgesetz zum Wohlstands- und Nachhaltigkeitsgesetz

OpenAIRE

Koll, Willi

2016-01-01

Das Stabilitäts- und Wachstumsgesetz wird bald 50 Jahre alt. Neue Herausforderungen erfordern eine Wirtschaftspolitik, die weit über die Ziele des Gesetzes hinausweist. Sie muss wirtschaftliches Wachstum und Stabilität mit den Zielen fiskalischer, sozialer und ökologischer Nachhaltigkeit auf nationaler und europäischer Ebene verbinden. Der Autor gibt einen Über blick über solche umfassenden Zielsysteme und leitet daraus ab, wie eine derart erweiterte wirtschaftspolitische Agenda in ein Wohlst...

Adsorption of Th(IV) and Pu(IV) on the surface of Pseudomonas fluorescens and Bacillus subtilis in the presence of desferrioxamine siderophore

International Nuclear Information System (INIS)

Yoshida, Takahiro; Ozaki, Takuo; Ohnuki, Toshihiko; Francis, Arokiasamy J.

2005-01-01

Adsorption of Th(IV) and Pu(IV) on a Gram-negative bacterium Pseudomonas fluorescens and a Gram-positive bacterium Bacillus subtilis in the presence of siderophore desferrioxamine B (DFO) was studied. Thorium(IV) and Pu(IV) were dissociated from DFO during adsorption on the cells. Thorium(IV) adsorption on bacterial cells in the presence of DFO was larger than that of Pu(IV) because of the smaller stability of the Th(IV)-DFO complex than that of the Pu(IV)-DFO complex. On the other hand, adsorption of Pu(IV) was larger than that of Fe(III), wherein the stability of the Pu(IV)- and Fe(III)-DFO complex is comparable. P. fluorescens showed a higher affinity for Th(IV) and Pu(IV) than B. subtilis, though potentiometric titration of bacterial cells indicated that surfaces of P. fluorescens and B. subtilis cells showed similar proton binding properties. (author)

Indications and technique of fetal magnetic resonance imaging; Indikationen und Technik der fetalen Magnetresonanztomographie

Energy Technology Data Exchange (ETDEWEB)

Asenbaum, U.; Woitek, R.; Furtner, J.; Prayer, D. [Medizinische Universitaet Wien, Abteilung fuer Neuroradiologie und Muskuloskelettale Radiologie, Universitaetsklinik fuer Radiodiagnostik, Wien (Austria); Brugger, P.C. [Medizinische Universitaet Wien, Zentrum fuer Anatomie und Zellbiologie, Wien (Austria)

2013-02-15

Evaluation and confirmation of fetal pathologies previously suspected or diagnosed with ultrasound. Ultrasound and magnetic resonance imaging (MRI). Technique for prenatal fetal examination. Fetal MRI is an established supplementary technique to prenatal ultrasound. Fetal MRI should only be used as an additional method in prenatal diagnostics and not for routine screening. Fetal MRI should only be performed in perinatal medicine centers after a previous level III ultrasound examination. (orig.) [German] Evaluierung und Bestaetigung von im praenatalen Ultraschall entdeckten Pathologien. Ultraschall und Magnetresonanztomographie. Praenatale Untersuchungsmethode. Die fetale MRT ist inzwischen als ergaenzende Methode zum praenatalen Ultraschall anerkannt. Die fetale MRT soll als additive Methode bei klinischer Relevanz, nicht jedoch als Routinescreeningverfahren waehrend der Schwangerschaft angewendet werden. Durchfuehrung ausschliesslich an einem Perinatalzentrum nach vorangegangenem Level-III-Ultraschall. (orig.)

Altautoverwertung zwischen Staat und Markt: Bedingungen und Potentiale zur Modernisierung von Lagerhaltung und Marketing gebrauchter Autoteile

OpenAIRE

Lucas, Rainer

2000-01-01

Das Arbeitspapier diskutiert vor dem Hintergrund veränderter gesetzlicher Rahmen-und Wettbewerbsbedingungen in der Autoverwertung Ziele und Maßnahmen zurStärkung kleiner und mittelständischer Verwertungsbetriebe. Der Bereich GebrauchteAutoteile wird im Rahmen eines regionalen Fallbeispiels einer tiefergehenden Analyseunterzogen. Hieraus werden Vorschläge zur regionalen Netzwerkbildung innerhalb derBranche und neue Dienstleistungsperspektiven abgeleitet. Ein wesentliches Koope-rationsfeld ist ...

Determination of uranium (IV) by flow voltammetry

International Nuclear Information System (INIS)

Ding Anqing

1987-01-01

According to the quantitative reaction of U(IV) and Fe(III) in H 2 SO 4 as well as the relation between current and concentration of substance detected, U(IV) has been determined indirectly by measurement of the electrolysis current of residual Fe(III). The columniform electrode used is made of glass carbon particles. At the range of U(IV) from a few micrograms to 40 μg, the linear relation is excellent. The relative standard deviation is within ±4%. The interference of Fe(II), Ti(IV) and U(VI) is negligible but of Ti(III) is serious. This method has been successfully applied in the determination of actual samples (both out line and on line). Main advantages of this procedure are rapid, simple, small amount of sample (only at microgram level) and easy to realize automation, able to use for on line or process analysis

Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer: Analysis of therapeutic results in 112 cases

International Nuclear Information System (INIS)

Mitsudo, Kenji; Koizumi, Toshiyuki; Iida, Masaki; Iwai, Toshinori; Nakashima, Hideyuki; Oguri, Senri; Kioi, Mitomu; Hirota, Makoto; Koike, Izumi; Hata, Masaharu; Tohnai, Iwai

2014-01-01

Purpose: To evaluate the therapeutic results and rate of organ preservation in patients with stage III or IV oral cancer treated with retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy. Materials and methods: One hundred and twelve patients with stage III and IV oral squamous cell carcinoma underwent intra-arterial chemoradiotherapy. Catheterization from the superficial temporal and occipital arteries was performed. Treatment consisted of superselective intra-arterial chemotherapy (docetaxel, total 60 mg/m 2 , cisplatin, total 150 mg/m 2 ) and daily concurrent radiotherapy (total of 60 Gy) for 6 weeks. Results: The median follow-up for all patients was 46.2 months (range, 10–76 months). After intra-arterial chemoradiotherapy, primary site complete response was achieved in 98 (87.5%) of 112 cases. Five-year survival and local control rates were 71.3% and 79.3%, respectively. Grade 3 or 4 toxicities included mucositis in 92.0%, neutropenia in 30.4%, dermatitis in 28.6%, anemia in 26.8%, and thrombocytopenia in 7.1% of patients. Grade 3 toxicities included dysphagia in 72.3%, nausea/vomiting in 21.4%, fever in 8.0%, and renal failure in 0.9% of patients. Conclusion: Retrograde superselective intra-arterial chemotherapy and daily concurrent radiotherapy for stage III and IV oral cancer provided good overall survival and local control

Kunstinäituselt Jumala ja kanade juurde ning sealt põrgusse / Riin Kübarsepp

Index Scriptorium Estoniae

Kübarsepp, Riin, 1978-

2005-01-01

Mirja-Mari Smidti ja Allan Tõnissoo näitus "Kunstinäitus" Hobusepea galeriis 31. III-18. IV. Tanel Saare "Gott und Huhn episode IV: seed shower" kuni 23. IV Draakoni galeriis. Kuni 24. IV Tallinna Linnagaleriis Pirjetta Branderi näitus "Põrgu ja teised jutud", millega oli kaasas Mikko Tuhkaneni kunstniku loomingu analüüsi sisaldav kirjutis "A Woman's work is never done"

Advanced Gastric Cancer: Differentiation of Borrmann Type IV versus Borrmann Type III by Two-Phased Dynamic Multi-Detector Row CT with Use of the Water Filling Method

Energy Technology Data Exchange (ETDEWEB)

Kim, Dae Jung; Yu, Jeong Sik; Lee, Sang Min; Kim, Joo Hee; Chung, Jae Joon; Kim, Ki Whang [Dept. of Radiology, Yonsei University College of Medicine, Gangnam Severance Hospital, Seoul (Korea, Republic of); Kang, Hae Youn [CHA Bundang Medical Center, CHA University, Seongnam (Korea, Republic of)

2013-02-15

To characterize Borrmann type IV from Borrmann type III advanced gastric cancer (AGC) by two-phased multi-detector row computed tomography (MDCT) using the water filling method. A total of 143 patients (pathologically confirmed Borrmann type III and IV - 100 and 43 patients), who underwent preoperative MDCT, were enrolled. Two radiologists, retrospectively and independently, determined tumor enhancement pattern using a 5-grade scale without clinical information. A weighted kappa test was applied for interobserver variability. The score of tumor enhancement pattern correlated with Borrmann type as determined by Spearman's correlation coefficient. The accuracy of differentiation of Borrmann type using MDCT was determined by receiver operating characteristic curves. Interobserver agreement (weighted kappa = 0.683) was substantial. The tumor enhancement pattern score showed a significant correlation with Borrmann type (reviewer 1, r = 0.591, p < 0.001; reviewer 2, r = 0.616, p < 0.001). The accuracy for differentiation of Borrmann type on MDCT was 0.86 (p < 0.001) in both reviewers. The sensitivity and specificity of the diagnosis of Borrmann type IV were 79% and 82% in reviewer 1, and 88% and 78% in reviewer 2, respectively. Dual-phased MDCT using the water filling method can differentiate between Borrmann type IV and III AGC with high accuracy.

Marktkonstitution und Regulierung der unabhängigen Film- und Fernsehproduktion : Staat, Verbände und Gewerkschaften im deutsch-britischen Vergleich

OpenAIRE

Elbing, Sabine; Voelzkow, Helmut

2006-01-01

"In einem internationalen Vergleich von Deutschland und Großbritannien wird untersucht, welche Beiträge die staatliche Politik und die Wirtschafts- und Sozialpartner (Wirtschafts- und Arbeitgeberverbände sowie Gewerkschaften) zur Förderung der unabhängigen Film- und Fernsehproduktion leisten. Es wird gezeigt, dass die britische Medienpolitik die Position der unabhängigen Film- und Fernsehproduktion gegenüber den Fernsehsendern gestärkt hat. In Deutschland hat die Medienpolitik darauf verzicht...

Measurement of Ce(IV) Concentration in Foam Decontaminant containing Fluorosurfactant

Energy Technology Data Exchange (ETDEWEB)

Jung, Chong Hun; Yang, H. B.; Yoon, I. H.; Choi, W. K.; Moon, J. K. [KAERI, Daejeon (Korea, Republic of); Lee, J. S. [Gachon University, Seongnam (Korea, Republic of)

2016-05-15

To improve the stability of the foam, surfactants and inorganic materials such as nanoparticles can be added. A nanoparticle-based foam decontaminant is composed of a surfactant and nanoparticles for the generation and maintenance of foam, and a chemical decontamination agent made of Ce(IV) dissolved in nitric acid. Ce(IV) will be reduced to Ce(III) through the decontamination process. Oxidizing the cerium (III) can be reused as a decontamination agent, Ce(IV). Oxidation treatment technology by ozone uses its strong oxidizing power. It can be regarded as an environmentally friendly process, because ozone cannot be stored and transported like other industrial gases (because it quickly decays into diatomic oxygen) and must therefore be produced on site, and used ozone can be decomposed immediately. A concentration analysis of Ce(IV) in foam decontaminant containing a surfactant is necessary prior to the derivation of optimal conditions for the regeneration of Ce(III) through ozonation treatment. A UV spectrometric method using the absorbance or potentiometric method with a potential difference in Ce(III)/Ce(IV), or a potentiometric titration method using Fe (II), can be used for a Ce(IV) concentration analysis. A UV spectrometric method has a problem receiving the influence of the surfactant, and a potentiometric method is difficult to use because of the problem of an insignificant change in the potential difference value of the Ce(III)/Ce(IV). Thus, the present study was undertaken to determine whether the potentiometric titration method can be used for an analysis of the Ce(IV) concentration in the nanoparticle-based foam decontaminant containing surfactant. It will be effectively used for the Ce(IV) concentration measurement, in relation to the subsequent research on the derivation of optimal conditions for the regeneration of Ce(III) through ozonation treatment.

Anti-SEMA4D Monoclonal Antibody VX15/2503 With Nivolumab or Ipilimumab in Treating Patients With Stage III or IV Melanoma

Science.gov (United States)

2018-04-26

Metastatic Melanoma; Stage III Cutaneous Melanoma AJCC v7; Stage IIIA Cutaneous Melanoma AJCC v7; Stage IIIB Cutaneous Melanoma AJCC v7; Stage IIIC Cutaneous Melanoma AJCC v7; Stage IV Cutaneous Melanoma AJCC v6 and v7

Erektile Dysfunktion, Phosphodiesterase-5-Hemmer und KHK - die Sicht des Kardiologen

Directory of Open Access Journals (Sweden)

Schmid P

2004-01-01

Full Text Available Die erektile Dysfunktion (ED kommt vermehrt bei Patienten mit koronarer Herzkrankheit (KHK vor und wird üblicherweise mit Phosphodiesterase- 5-Hemmern (PDE-5-Hemmer wie Sildenafil, Vardenafil und Tadalafil behandelt. Dies geht mit einem systemischen Blutdruckabfall von bis zu 10 mmHg systolisch und bis 6 mmHg diastolisch einher. Die Herzfrequenz bleibt gleich oder steigt minimal an, das Doppelprodukt (RR sys x HF als Maß des myokardialen Sauerstoffverbrauches bleibt unverändert oder sinkt ab. Koronarangiographische Untersuchungen bei KHK-Patienten unter Sildenafil ergaben gegenüber Placebo keine Unterschiede in der Hämodynamik. Auch die Koronarreserve, die Blutflußgeschwindigkeit, der Durchmesser der Koronararterien, das Blutflußvolumen und der Koronargefäßwiderstand blieben unbeeinflußt. Die körperliche Leistungsfähigkeit wurde durch Sildenafil und Vardenafil nicht verändert. Eine kardiovaskuläre Exzeßmortalität liegt durch Einnahme von PDE-5-Hemmern nicht vor. Absolute Kontraindikation für eine Therapie mit PDE-5-Hemmern ist die gleichzeitige Gabe von NO-Donatoren (Nitrate, Molsidomin, Nitroprussid-Natrium, relative Kontraindikationen sind eine akute Koronarinsuffizienz, Herzinsuffizienz mit niedrigem Blutdruck, vorbestehende antihypertensive 3- bis 4-fach-Kombinationstherapie, Pharmaka, die den Abbau bzw. die Elimination von PDE-5-Hemmern reduzieren, sowie Antiarrhythmika der Klasse III.

Sport und soziale Integration

OpenAIRE

Turan, Günes

2012-01-01

Sport und soziale Integration : Chancen, Probleme und Perspektiven für Städte und Kommunen ; Tagungsband der gleichnamigen Tagung am 28. und 29. Juni 2011 in Augsburg / Helmut Altenberger ... (Hrsg.). - Hamburg : Feldhaus, Ed. Czwalina, 2012. - 104 S. - (Sportwissenschaft und Sportpraxis ; 161)

Formation of Ti(III) and Ti(IV) states in Ti{sub 3}O{sub 5} nano- and microfibers obtained from hydrothermal annealing of C-doped TiO{sub 2} on Si

Energy Technology Data Exchange (ETDEWEB)

Stem, Nair, E-mail: nairstem@hotmail.com [Laboratório de Sistemas Integráveis (LSI), Escola Politécnica, Universidade de São Paulo, Av. Prof. Luciano Gualberto 158, 05508900 São Paulo, SP (Brazil); Souza, Michele L.; Araújo de Faria, Dalva Lúcia Araújo [Laboratório de Espectroscopia Molecular (LEM), Instituto de Química, Universidade de São Paulo, Av. Prof. Lineu Prestes 748, 05508900 São Paulo, SP (Brazil); Santos Filho, Sebastião G. dos [Laboratório de Sistemas Integráveis (LSI), Escola Politécnica, Universidade de São Paulo, Av. Prof. Luciano Gualberto 158, 05508900 São Paulo, SP (Brazil)

2014-05-02

In this work, it is investigated the formation of Ti(III) and Ti(IV) states at the surface and in the bulk of the Ti{sub 3}O{sub 5} material grown as meshes of nano- and micro-fibers obtained from hydrothermal annealing of C-doped TiO{sub 2} on Si. The topography and distribution of the fibers in the meshes were characterized by atomic force microscopy. When the fiber distribution was more compact, a higher photoluminescence signal at 850 nm (1.46 eV) was obtained, indicating the presence of a higher number of defects corresponding to the Ti(III) sites. From X-ray photoelectron spectroscopy, it was obtained a Ti(III)/Ti(IV) ratio much lower than the expected value for the Ti{sub 3}O{sub 5} phase (2 Ti(III): 1 Ti(IV)). The discrepancy was mainly attributed to the reaction of surface Ti(III) states of the Ti{sub 3}O{sub 5} fibers with water during the hydrothermal annealing, resulting in surface Ti(IV) with -OH radicals. On the other hand, X-ray photoelectron spectroscopy also indicated that substitutional and interstitial carbon atoms coexist, elemental carbon exists in the samples due to the co-deposition process and, as a result, the carbon inside of the TiO{sub 2} rutile lattice is acting as one of the precursors for the formation of Ti{sub 3}O{sub 5}. - Highlights: • Ti(III) states are detected inside of Ti{sub 3}O{sub 5} nano- and microfibers. • Ti(IV) states are predominantly detected on the surface of Ti{sub 3}O{sub 5} nano- and microfibers. • Photoluminescence at 850 nm for Ti{sub 3}O{sub 5} is due to defects associated to Ti(III). • Rutile possibly changes to C2/m Ti{sub 3}O{sub 5} during the hydrothermal annealing of C-doped TiO{sub 2}.

Kommunikation und Lernen in partizipativen kulturellen und medialen Räumen

Directory of Open Access Journals (Sweden)

Elke Zobl

2012-12-01

Full Text Available Eine der interessantesten Transformationen in der Jugendkultur seit den 1990er-Jahren ist die steigende Zahl vor allem an Mädchen und jungen Frauen, die zu aktiven kulturellen Produzentinnen wurden. In diesem Artikel wird argumentiert, dass sie mit ihren eigenen kulturellen Produktionen und Netzwerken neue soziale und mediale Räume öffnen, die durch eine partizipative Kultur, selbst-organisiertes Lernen in informellen Kontexten und lokale, transnationale und virtuelle Vernetzung und Kommunikation geprägt sind. Ziel dieses Artikels ist es, das Kommunizieren und Lernen in partizipativen kulturellen (bzw. sozialen und medialen Räumen am Beispiel queer-feministischer Festivals – sogenannter „Ladyfeste“ – darzustellen und ihre Bedeutung in (medien-pädagogischen Kontexten zu diskutieren.One of the most interesting transformations in youth culture since the 1990s is the growing number of girls and young women as active cultural producers. By creating their own cultural productions and networks, this article argues, that they open up new cultural (i. e. social and media spaces which are characterized by a participatory culture, self-organised learning and local, transnational and virtual networks and communication. Taking the example of queer-feminist festivals (so called “Ladyfests”, the aim of this article is to discuss communication and learning in participatory cultural and media spaces and their meaning in the context of (media-pedagogy.

Oxochloroalkoxide of the Cerium (IV and Titanium (IV as oxides precursor

Directory of Open Access Journals (Sweden)

Machado Luiz Carlos

2002-01-01

Full Text Available The Cerium (IV and Titanium (IV oxides mixture (CeO2-3TiO2 was prepared by thermal treatment of the oxochloroisopropoxide of Cerium (IV and Titanium (IV. The chemical route utilizing the Cerium (III chloride alcoholic complex and Titanium (IV isopropoxide is presented. The compound Ce5Ti15Cl16O30 (iOPr4(OH-Et15 was characterized by elemental analysis, FTIR and TG/DTG. The X-ray diffraction patterns of the oxides resulting from the thermal decomposition of the precursor at 1000 degreesC for 36 h indicated the formation of cubic cerianite (a = 5.417Å and tetragonal rutile (a = 4.592Å and (c = 2.962 Å, with apparent crystallite sizes around 38 and 55nm, respectively.

Factors associated with a poor prognosis for the IVF-ICSI live birth rate in women with rAFS stage III and IV endometriosis.

Science.gov (United States)

Roux, Pauline; Perrin, Jeanne; Mancini, Julien; Agostini, Aubert; Boubli, Léon; Courbiere, Blandine

2017-07-01

To assess the factors associated with a poor prognosis for a cumulative IVF live birth rate (LBR) in women with stage III and IV endometriosis according to the revised classification of the American Fertility Society (rAFS). A retrospective cohort study was conducted between January 1, 2010, and December 31, 2014, in our Reproductive Medicine Center. We analyzed different factors associated with a poor prognosis for a cumulative IVF LBR in women with rAFS stage III and IV endometriosis. A total of 101 patients were included, representing 232 IVF-ICSI cycles and 212 embryo transfers. The primary endpoint was the cumulative LBR per cycle and per patient. The cumulative LBR per cycle was 14.7% (n = 34) and that per patient was 31.7% (n = 32). The cumulative LBR was significantly decreased by active smoking [ adj OR = 3.4, 95% CI (1.12-10.60), p = 0.031], poor ovarian response (POR) according to the Bologna criteria [ adj OR = 11.5, 95% CI (1.37-96.83), p = 0.024], and rAFS stage IV [ adj OR = 3.2, 95% CI (1.13-8.95), p = 0.024]. The cumulative LBR per women was 59.4% without factors associated with a poor prognosis and 25.6% in the case of one factor, and it decreased to 7.7% in the case of two or three factors (p endometriosis had a negative impact on the IVF-ICSI cumulative LBR for women with rAFS stage III and IV endometriosis. Because smoking dramatically decreases the LBR with endometriosis, stopping smoking before IVF-ICSI should be strongly advised.

Ausbildung und Erwartungshaltung

Science.gov (United States)

Knoke, Holger

1997-09-01

werden Geologiestudenten zeitgemäß ausgebildet? Wird in der Angewandten Geologie das gelehrt, was in Wirtschaftsunternehmen an Wissen von einem Geologen erwartet wird? Erfolgt die spezielle Ausbildung zum Hydrogeologen fundiert und umfassend? Eine Antwort auf diese Fragen kann sicherlich nicht allumfassend gegeben werden, da sie von der jeweiligen Sichtweise abhängig ist. Ein Geologieprofessor wird die Ausbildung seiner Studenten im Großen und Ganzen als zeitgemäß einstufen, eventuell hier und da Verbesserungen für möglich halten. Auffällig ist die hohe Anzahl der in den letzten Jahren bereits geänderten oder zur Änderung anstehenden Studienordnungen. Es zeigt, daß die Straffung des Studiums sowie eine zumindest teilweise neue Wichtung der Schwerpunkte notwendig war bzw. ist, wobei im allgemeinen eine höhere Stundenzahl in den Grundlagenfächern Mathematik, Physik und Chemie angesetzt wird. Betrachtet man die Gesamtstundenzahlen der alten und der reformierten Studienordnungen, kann jedoch von einer Kürzung der Pflichtstunden in den meisten Fällen nicht die Rede sein. Eine grundlegende Reform des Geologiestudiums ist zur Zeit nicht zu erkennen, eher eine Verschulung des Studienganges. Die Entwicklung scheint zur Zeit weg von der freien Kurswahl und hin zu Modulangeboten mit vorgegebenen Kursen und Reihenfolgen zu gehen. Für die Hydrogeologie-Professoren ist es sicherlich nicht einfach zu entscheiden und in ihrem Kollegenkreis durchzusetzen, was aus dem generellen geowissenschaftlichen Kursangebot für einen Hydrogeologen notwendig oder aber entbehrlich ist. Genügen die Grundlagen der Paläontologie und der Mineralogie? Kann man ganz darauf verzichten? Was erwarten Behörden und Wirtschaftsunternehmen an allgemeinen und Spezialkenntnissen? Geologische Landesämter z. B. wollen, pauschal betrachtet, Geologen alten Stils. Ist ausdrücklich ein Angewandter Geologe oder speziell ein Hydrogeologe erwünscht, soll dieser die Spezialkenntnisse zus

[Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Letgallen. Stadt, Land und Konfession 1500-1721. 2. und 3. Teil] / Anti Selart

Index Scriptorium Estoniae

Selart, Anti, 1973-

2012-01-01

Arvustus: Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Letgallen. Stadt, Land und Konfession 1500-1721. Hrsg. von Matthias Asche, Werner Buchholz, Anton Schindling. 2. und 3. Teil.

Evaluación de la calidad de los consentimientos informados de los servicios de los hospitales de nivel III-IV de Lima y Callao.

Directory of Open Access Journals (Sweden)

Germán Málaga Rodriguez

2007-07-01

Full Text Available Objetivo: Evaluar la calidad de los formatos de consentimiento médico informado para cirugía mayor utilizados en los diferentes servicios de los hospitales de nivel III-IV de Lima y Callao. Material y métodos: Estudio descriptivo, cualitativo y transversal. Obtenidos los formatos de consentimiento médico informado para cirugía mayor utilizados en los servicios de los hospitales de nivel III - IV del Lima y Callao; se evaluó su calidad contrastándolos con una plantilla de requisitos elaborada con base en la literatura. Resultados: De los 28 formatos de consentimiento médico informado para cirugía mayor de 20 hospitales de nivel III-IV en Lima y Callao evaluados, 14,2% cumplían con más del 75% de los requisitos; 57,2%, con 75-50%; y 28,6%, con menos del 50%. Los requisitos acerca del procedimiento y sus características estuvieron ausentes en más del 75% de los formatos. Los formatos de los hospitales pertenecientes al Ministerio de Salud (MINSA cumplieron en promedio con 12 requisitos (rango 4-21; los de las Fuerzas Armadas (FFAA, con 17 (rango 14-18; y los del EsSALUD, con 18 (rango16-22. Conclusiones: Los formatos de CMI de los servicios de los hospitales de nivel III-IV de Lima Callao evaluados no presentan uniformidad entre ellos y no garantizan que el paciente ha sido completa y correctamente informado ni que se ha respetado su autonomía en la toma de decisión. Los formatos de CMI del MINSA fueron los más deficientes y los que presentaron mayor variabilidad de calidad. Se propone un modelo de CMI para ser tomado como base por los diferentes servicios de hospitales para la elaboración de futuros CMI.(Rev Med Hered 2007;18:136-142

The hyperfractionation in the oropharynx carcinomas treatment: stages III and IV

International Nuclear Information System (INIS)

Pinto, L.H.J.

1990-01-01

From April 1986 until May 1989. 112 patients with stages III and IV oropharynx carcinomas were included in a protocol comparing the use of Hyperfractionation and Conventional Fractionation. The doses were 6600 rad in 33 fractions of 200 rad for the conventional fractionation and 7040 rad in 64 fractions, two fractions of 110 rad per day for the hyperfractionation. As of January 1990 an analysis was performed in 98 patients, with a median follow-up of 14 months. The probability of complete responses in the oropharynx was 74%, with 84% for the hyperfractionation and 64% for the conventional fractionation ( p < 0,05). Survival was improved in 42 months for those patients treated with hyperfractionation: 27% versus 8% (p < 0,05). In patients with lesions out of the base of the tongue and in those with Karnofsky performance status of 50%, 60% and 70%, survival was improved with the use of hyperfractionation (p = 0,02 and p 0,006 respectively. The study demonstrates the superiority of hyperfractionation over the classical fractionation in the treatment of patients with carcinoma of the oropharynx. (author)

Optimized FFTF Acceptance Test Program covering Phases III, IV, and V

International Nuclear Information System (INIS)

Wykoff, W.R.; Jones, D.H.

1977-03-01

A detailed review of Phases III, IV, and V of the FFTF Acceptance Test Program has been completed. The purpose of this review was to formulate that test sequence which not only meets requirements for safe, reliable and useful operation of the plant, but also results in the earliest prudent demonstration of full-power performance. A test sequence based on the underlying assumption that sodium flows into the secondary sodium storage tank (T-44) no later than August 31, 1978, is described in detail. A time-scale which allows extra time to put systems and equipment into operation the first time, debugging, and learning how to operate most effectively has been superimposed on the test sequence. Time is not included for major equipment malfunctions. This test plan provides the basis for coordinating the many and varied activities and interfaces necessary for successful and timely execution of the FFTF Acceptance Test Program. In this report, the need dates have been identified for presently scheduled test articles and standard core components

Characterization of a tricationic trigonal bipyramidal iron(IV) cyanide complex, with a very high reduction potential, and its iron(II) and iron(III) congeners.

Science.gov (United States)

England, Jason; Farquhar, Erik R; Guo, Yisong; Cranswick, Matthew A; Ray, Kallol; Münck, Eckard; Que, Lawrence

2011-04-04

Currently, there are only a handful of synthetic S = 2 oxoiron(IV) complexes. These serve as models for the high-spin (S = 2) oxoiron(IV) species that have been postulated, and confirmed in several cases, as key intermediates in the catalytic cycles of a variety of nonheme oxygen activating enzymes. The trigonal bipyramidal complex [Fe(IV)(O)(TMG(3)tren)](2+) (1) was both the first S = 2 oxoiron(IV) model complex to be generated in high yield and the first to be crystallographically characterized. In this study, we demonstrate that the TMG(3)tren ligand is also capable of supporting a tricationic cyanoiron(IV) unit, [Fe(IV)(CN)(TMG(3)tren)](3+) (4). This complex was generated by electrolytic oxidation of the high-spin (S = 2) iron(II) complex [Fe(II)(CN)(TMG(3)tren)](+) (2), via the S = 5/2 complex [Fe(III)(CN)(TMG(3)tren)](2+) (3), the progress of which was conveniently monitored by using UV-vis spectroscopy to follow the growth of bathochromically shifting ligand-to-metal charge transfer (LMCT) bands. A combination of X-ray absorption spectroscopy (XAS), Mössbauer and NMR spectroscopies was used to establish that 4 has a S = 0 iron(IV) center. Consistent with its diamagnetic iron(IV) ground state, extended X-ray absorption fine structure (EXAFS) analysis of 4 indicated a significant contraction of the iron-donor atom bond lengths, relative to those of the crystallographically characterized complexes 2 and 3. Notably, 4 has an Fe(IV/III) reduction potential of ∼1.4 V vs Fc(+/o), the highest value yet observed for a monoiron complex. The relatively high stability of 4 (t(1/2) in CD(3)CN solution containing 0.1 M KPF(6) at 25 °C ≈ 15 min), as reflected by its high-yield accumulation via slow bulk electrolysis and amenability to (13)C NMR at -40 °C, highlights the ability of the sterically protecting, highly basic peralkylguanidyl donors of the TMG(3)tren ligand to support highly charged high-valent complexes.

The role of stereotactic 11G vacuum biopsy for clarification of BI-RADS{sup TM} IV findings in mammography; Wertigkeit der stereotaktischen 11 G-Vakuumbiopsie zur Abklaerung von Befunden der Kategorie BI-RADS{sup TM} IV in der Mammographie

Energy Technology Data Exchange (ETDEWEB)

Diebold, T.; Jacobi, V.; Ballenberger, S.; Hochmuth, K.; Balzer, J.O.; Vogl, T.J. [Inst. fuer Diagnostische und Interventionelle Radiologie, Klinikum der J.W.G.-Univ. Frankfurt/Main (Germany); Krapfl, E.; Minckwitz, G. v.; Solbach, C.; Kaufmann, M. [Klinik fuer Gynaekologie und Geburtshilfe, Klinikum der J.W.G.-Univ. Frankfurt/Main (Germany); Fellbaum, M. [Senckenbergisches Inst. fuer Pathologie, Klinikum der J.W.G.-Univ. Frankfurt/Main (Germany)

2003-04-01

Purpose: To evaluate the potential of stereotactic vacuum breast biopsy in the histologic evaluation of suspicious mammographic findings (BI-RADS{sup TM} IV). Materials und Methods: In 221 patients with 227 probable mammographic lesions categorized as (BI-RADS{sup TM}-IV), stereotactic biopsies were performed with an 11-gauge vacuum-assisted biopsy device (Mammotome). The evaluation included the histology of the specimens obtained with the Mammotome or with surgery, the time for the biopsy, the amount of bleeding, number of rotations and procured specimens, the extent of the resection and the complications. Results: The biopsies were technically successful in 214 of the 227 probable mammographic lesions, with 176 lesions mostly resected and 34 lesions removed more than 50%. No representative tissue was obtained from 4 lesions. All biopsies were performed without any clinically relevant complications and terminated after adequate material was obtained (Oe 28 specimens, 2.58 rotations). The mean time needed for performing the biopsy was 40.2 minutes. The histologic findings were DCIS (42 lesions), ADH (7 lesions), LCIS (3 lesions), ID-Ca (14 lesions), IL-Ca (3 lesions), and IDL-Ca (1 lesion). In 28 of 42 lesions with the initial DCIS histology, the surgical histology was also DCIS (n=28) or no residual tumor (n=10). In 4 lesions with an initial DCIS-histology, the surgical histology was invasive ductal cancer (9.5%). The late follow-up examinations (up to 3 years) did not find any evidence of a false negative biopsy. Conclusion: Stereotactic vacuum breast biopsy ideally complements existing breast biopsy methods. The method is minimal invasive with a low rate of mostly minor complications. (orig.) [German] Ziel: Evaluierung der Wertigkeit der stereotaktischen Vakuumbiopsie zur Abklaerung von Befunden der Kategorie BI-RADS{sup TM} IV in der Mammographie. Material und Methode: Bei 221 Patientinnen mit 227 mammographischen Laesionen der BI-RADS{sup TM}-Kategorie IV

Study on the diagnostic value of determination of serum IV-C, PC III, HA, LN and PLD concentrations for hepatic fibrosis in patients with B hepatitis of various types

International Nuclear Information System (INIS)

Li Zhuocheng; Chen Jianxiong; Xiong Ying

2004-01-01

Objective: To investigate the changes of serum levels of collagen type IV(IV-C), procollagen type III (PC III), hyaluronic acid (HA), laminin (LN) and prolidase (PLD) and their relationship with hepatic fibrosis in patients with B hepatitis of different types. Methods: Serum levels of IV-C, PC III, HA, LN and PLD were measured with RIA in 39 controls and 103 patients with HBV infection of various types (including acute hepatitis AH n=19, chronic persistent hepatitis CPH n=29, Chronic active hepatitis CAH n=25 and liver cirrhosis LH n=30. Degree of hepatic fibrosis (Grade 0-4) was ascertained with liver biopsy in 35 patients (CAH16, LC19) and correlationship with the corresponding levels of these 5 serum markers was steadied. Results: 1) Serum levels of IV-C, PC III, HA, LN and PLD were significantly higher in patients with CAH and LC than those in other patients and controls (P 0.05). 3) Serum levels of these markers were all positively correlated with the degree of hepatic fibrosis noted in the biopsy specimens obtained from patients with CAH (n=16) and LC (n=19) (r=+0.64 - + 0.89, P<0.01). Conclusion: Serum levels of these markers could reflect the degree of hepatic fibrosis and severity of liver damage; determination of which was of diagnostic and even prognostic value. HA and LN appeared to be better correlated with degree of hepatic fibrosis than the remaining three markers did. (authors)

Mediendidaktik und Wissensmanagement

Directory of Open Access Journals (Sweden)

Gabi Reinmann-Rothmeier

2002-10-01

Full Text Available Mediendidaktik und Wissensmanagement – das ist auf den ersten Blick ein ungleiches Paar: Die Mediendidaktik ist eine Teildisziplin der (Medien- Pädagogik, während Wissensmanagement ein genuin wirtschaftliches Thema mit betriebswirtschaftlichen Akzenten ist. Annäherungen zwischen der Mediendidaktik und Wissensmanagement gibt es zum einen durch den sog. E-Learning-Trend seitens der Wirtschaft, der mediendidaktisches Wissen und Können auf den Plan ruft, zum anderen durch wachsendes Interesse am Thema Wissensmanagement seitens der Pädagogik. Der Beitrag beschreibt sowohl für das E-Learning als auch für das Wissensmanagement aus pädagogisch-psychologischer Sicht jeweils ein Orientierungsmodell; beide Modelle machen die Berührungspunkte zwischen Mediendidaktik und Wissensmanagement deutlich. Neben einem Überblick über wirtschaftliche Argumente für eine Verschmelzung von E-Learning und Wissensmanagement werden aufbauend auf den beiden Orientierungsmodellen theoretische und praktische Verbindungslinien zwischen E-Learning und Wissensmanagement sowie die Rolle der Mediendidaktik in dem daraus entstehenden Wechselverhältnis herausgearbeitet.

Haemophilic arthropathy of the knee. Gd-DTPA enhanced MRT. Clinical and radiological correlation; Haemophile Arthropathie des Kniegelenkes. Gd-DTPA-verstaerkte MRT: klinische und roentgenologische Korrelation

Energy Technology Data Exchange (ETDEWEB)

Naegele, M. [Radiologische Universitaetsklinik, Bonn (Germany); Kunze, V. [Radiologische Universitaetsklinik, Bonn (Germany); Hamann, M. [Radiologische Universitaetsklinik, Bonn (Germany); Eickhoff, H. [Orthopaedische Klinik, Krankenhaus Troisdorf (Germany); Koch, W. [Orthopaedische Klinik, Krankenhaus Troisdorf (Germany); Oldenburg, J. [Inst. fuer Experimentelle Haematologie und Transfusionsmedizin, Bonn (Germany); Reiser, M. [Muenchen Univ. (Germany). Inst. fuer Radiologische Diagnostik; Steudel, A. [Radiologische Universitaetsklinik, Bonn (Germany)

1994-02-01

17 patients with hemophilic arthropathy of the knee joint were studied with static and dynamic MRT before and after i.v. bolus injection of Gadolinium-DTPA (0,1 mmol/kg body weight). After contrast enhancement, synovial proliferations exhibited an increase of signal intensity (SI) of FFE and SE images of 47.7% and 37.4% respectively, whereas muscle and fatty tissue, tendons, bone marrow and joint effusion revealed only minor increase in SI. The gradient of signal intensity (ratio SI/time) of pannus was 39,6% min. Gd-DTPA enhanced MRI studies delineate and quantify the synovial proliferations in hemophilic arthropathy. Dynamic studies in hemophilic arthropathy do not provide qualitative assessment of the inflammatory process. (orig.) [Deutsch] Es wurden 17 Patienten mit einer haemophilen Arthropathie der Kniegelenke mit der statischen und dynamischen MRT vor und nach i.v. Bolusgabe von Gadolinium-DTPA (0,1 mmol/kg KG) untersucht. Nach Kontrastmittelgabe konnte ein Anstieg der Signalintensitaet des Pannus von 37,4% auf SE- und von 47,7% auf FFE-Aufnahmen gemessen werden. Der Gradient des Signalintensitaetsanstieges (%/Zeit) lag fuer Pannus bei 39,6%/min. Die Kontrastmittelgabe steigerte die Abgrenzbarkeit des Pannus von Gelenkerguss und den Gelenkbinnenstrukturen. Begleitend durchgefuehrte klinische und roentgenologische Bewertungen des Schweregrades der Arthropathie korrelierten nicht mit dem Signalintensitaetsverhalten des Pannus nach Kontrastmittelgabe. (orig.)

Spectrum of bone marrow changes in patients of chronic kidney disease (stage iii, iv and v)

International Nuclear Information System (INIS)

Latif, R.K.; Khan, S.A.; Ahmad, S.Q.; Arshad, U.

2017-01-01

To see the various hematological changes in the bone marrow of patients with chronic kidney disease (CKD) stage III, IV and V. Study Design: Cross sectional observational study.Place and Duration of Study: Study was conducted in the department of haematology (Pathology), Army Medical College, Rawalpindi and duration was one year, from Mar 2015 to Feb 2016. Material and Methods: Patients of both sexes and all age groups with CKD stage III, IV and V were included in this study. Patients' histories were recorded. Complete blood counts, bone marrow aspiration and trephine biopsy were done and evaluated microscopically. Mean blood counts of the patients in three groups of CKD were compared. Frequencies of various bone marrow (BM) findings in patients of CKD were calculated. Results: Out of 57 patients, 41 (71.9%) were males while 16 (28%) were females. Mean age was 60 years. There was no statistically significant difference between the mean hemoglobin, mean white cell count and mean platelets count of the patients in three groups of CKD. Reactive changes due to underlying CKD and inflammation were the most frequent findings in the BM of the patients. Conclusion: Anaemia of mild to moderate severity and reactive changes in the BM are the most frequent haematological findings encountered in patients suffering from advanced stage CKD. Since CKD is predominantly a disease of the elderly so it is not rare to find the co-morbidities including plasmacytosis, malignancies and their effects on the BM in patients of CKD. (author)

A new oxidimetric reagent: potassium dichromate in a strong phosphoric acid medium--VII. Photometric titration of vanadium(IV) and of cerium(III) alone and in mixtures with iroN(II).

Science.gov (United States)

Rao, G G; Rao, P K

1967-01-01

Vanadium(IV) can be accurately titrated with potassium dichromate in media containing phosphoric acid of 3-12M concentration: the change in absorption of vanadium(IV) is followed in the region 660 mmicro using a red filter. It is more convenient to carry out the titration in 3M phosphoric acid because at higher concentrations chloride, nitrate, cerium(III) and manganese(II) may interfere. Photoelcetric titration is more convenient than potentiometric because the former can be made in a 3M phosphoric acid medium, whereas the latter is possible only in 12M phosphoric acid. The simultaneous differential photometric titration of iron(II) and vanadium(IV) is also possible. Conditions have been found for the photometric titration of cerium(III) and of cerium(III) plus iron(II). The titration is carried out (at 450 mmicro or with a blue filter) in about 10.5M phosphoric acid. Application of the method to a cerium mineral is considered.

Extraction of Eu(III) and Th(IV) with TBP in n-dodecane in the presence of nitric acid and the thermodynamic activity of the TBP in the system

International Nuclear Information System (INIS)

Santos, F.S.M. dos.

1983-02-01

A qualitative description of the behavior of distribution coefficients of nitric acid, Th(IV) and Eu(III) separately in the system HNO 3 -H 2 O-TBP-n-dodecane and the effect of the temperature in the distribution coefficient of Th(IV) are presented. The distribution coefficient of Eu(III) between aqueous solutions nitric acid and solutions of TBP in n-dodecane are measured. Since the composition of the extracted Eu(III) complex is known, the theoretical course of the dependency of the distribution coefficient on the TBP concentration can be predicted. Deviations of experimental dependencies from theoretical ones give them information about the thermodynamic activity of TBP in the organic phase. A mathematical description for the distribution coefficients of Eu(III) and HNO 3 in the mentioned system was sugested. This description will make possible an avaliation of the behavior of the activity coefficients of TBP in the organic phase. (A.R.H.) [pt

Romanistik und gender studies

Directory of Open Access Journals (Sweden)

Susanne Schlünder

2000-11-01

Full Text Available Die beiden Bände bieten ein breites Spektrum von Beiträgen zur französischen, italienischen und spanischen Literaturwissenschaft. Gedankliche Grundlage der im einzelnen unterschiedlichen Ansätze und Zielsetzungen ist ein im Anschluß an Judith Butler gender-reflektierendes, diskursives Konzept von Geschlecht, dessen wissenschaftsgeschichtliche Herleitung und Perspektiven Renate Kroll einleitend darlegt. Die einzelnen Artikel beschäftigen sich zum einen mit literarischen Strategien, die Schriftstellerinnen vom Mittelalter bis zur Gegenwart erprobt haben, und hinterfragen dabei die Rolle weiblicher Autoren in Literaturgeschichte und Literaturgeschichtsschreibung. Zum anderen widmen sie sich den literarischen Inszenierungs- und Repräsentationsformen von Weiblichkeit und stellen darüber einen Bezug zur Lebenswelt der behandelten Autorinnen her.

Oxidation of Ce(III) in Foam Decontaminant by Ozone

Energy Technology Data Exchange (ETDEWEB)

Jung, Chong Hun; Yoon, I. H.; Choi, W. K.; Moon, J. K.; Yang, H. B. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of); Lee, J. S. [Gachon University, Seongnam (Korea, Republic of)

2016-10-15

A nanoparticle-based foam decontaminant is composed of a surfactant and nanoparticles for the generation and maintenance of foam, and a chemical decontamination agent made of Ce(IV) dissolved in nitric acid. Ce(IV) will be reduced to Ce(III) through the decontamination process. Oxidizing cerium(III) can be reused as a decontamination agent, Ce(IV). Oxidation treatment technology by ozone uses its strong oxidizing power. It can be regarded as an environmentally friendly process, because ozone cannot be stored and transported like other industrial gases (because it quickly decays into diatomic oxygen) and must therefore be produced on site, and used ozone can decompose immediately. The ozonation treatment of Ce(III) in foam decontaminant containing a surfactant is necessary for the effective regeneration of Ce(III). Thus, the present study was undertaken to determine the optimal conditions for ozonation treatment in the regeneration of Ce(III) into Ce(IV) in the nanoparticle-based foam decontaminant containing surfactant. This study was undertaken to determine the optimal conditions for ozonation treatment in the regeneration of Ce(III) to Ce(IV) in nanoparticle-based foam decontaminant containing a TBS surfactant. The oxidation conversion rate of Ce(III) was increased with an increase in the flow rate of the gas mixture and ozone injection amount. The oxidation time required for the 100% oxidation conversion of Ce(III) to Ce(IV) at a specific ozone injection amount can be predicted from these experimental data.

Oxidation of Ce(III) in Foam Decontaminant by Ozone

International Nuclear Information System (INIS)

Jung, Chong Hun; Yoon, I. H.; Choi, W. K.; Moon, J. K.; Yang, H. B.; Lee, J. S.

2016-01-01

A nanoparticle-based foam decontaminant is composed of a surfactant and nanoparticles for the generation and maintenance of foam, and a chemical decontamination agent made of Ce(IV) dissolved in nitric acid. Ce(IV) will be reduced to Ce(III) through the decontamination process. Oxidizing cerium(III) can be reused as a decontamination agent, Ce(IV). Oxidation treatment technology by ozone uses its strong oxidizing power. It can be regarded as an environmentally friendly process, because ozone cannot be stored and transported like other industrial gases (because it quickly decays into diatomic oxygen) and must therefore be produced on site, and used ozone can decompose immediately. The ozonation treatment of Ce(III) in foam decontaminant containing a surfactant is necessary for the effective regeneration of Ce(III). Thus, the present study was undertaken to determine the optimal conditions for ozonation treatment in the regeneration of Ce(III) into Ce(IV) in the nanoparticle-based foam decontaminant containing surfactant. This study was undertaken to determine the optimal conditions for ozonation treatment in the regeneration of Ce(III) to Ce(IV) in nanoparticle-based foam decontaminant containing a TBS surfactant. The oxidation conversion rate of Ce(III) was increased with an increase in the flow rate of the gas mixture and ozone injection amount. The oxidation time required for the 100% oxidation conversion of Ce(III) to Ce(IV) at a specific ozone injection amount can be predicted from these experimental data

Structural characterization of M(IV)1-xLn(III)xO2-x/2 (M = Ce, Th) mixed-oxides prepared from oxalate precursors. Multi-parametric study of dissolution and microstructural evolution

International Nuclear Information System (INIS)

Horlait, D.

2011-01-01

In the framework of Gen IV program development, several physico-chemical properties of some foreseen fuels, including the chemical durability, have to be evaluated. In this aim, a study was undertaken on M(IV) 1-x Ln(III) x O 2 (M=Ce,Th) model compounds prepared from oxalate precursors. The fluorite-type structure of CeO 2 and ThO 2 remains stable up to x ≅ 0.4, the substitution of M(IV) by Ln(III) occurring simultaneously to the formation of oxygen vacancies. For higher x values, a cubic superstructure is formed as a result of oxygen vacancies ordering. The normalized dissolution rates of such solids were found to be strongly enhanced by the Ln(III) fraction. On the contrary, the nature of the M(IV) and Ln(III) elements did not modify significantly the normalized dissolution rates. The effect of temperature and acid concentration suggested the existence of surface-controlling dissolution reactions. Simultaneously, the microstructural evolution of both powdered and sintered samples revealed some important changes in the reactive surface during dissolution tests. ESEM images allowed observing the existence of preferential dissolution sites located at grains boundaries and around crystalline defects, leading to the formation of corrosion pits. In addition, the formation of gelatinous phases, acting as diffusion barriers (thus slowing down the dissolution process) was also evidenced. (author) [fr

Correlation functions for the distribution coefficients of U(IV) and Pu(III) ions between aqueous nitric acid and 30% TBP in an aliphatic diluent

International Nuclear Information System (INIS)

Geldard, J.F.; Beyerlein, A.L.; Phillips, L.

1985-01-01

Distribution coefficient correlations for U(IV) and Pu(III) are obtained in terms of a modified form of the total nitrate ion salting strength that was successfully used to obtain distribution coefficient correlations for U(VI) and Pu(IV) in the earlier work of G.L. Richardson. The modification of salting strength was needed to account for the fact that the U(IV) distribution coefficients measured under conditions where U(VI) is present consistently fall below those obtained when it is absent. The correlations were incorporated into the mixer-settler computer model PUBG, and in the simulation of a 20-stage 1B partitioning contactor, calculated product stream concentrations were in excellent agreement with experiment. Earlier mixer-settler computer models, which failed to account for U(IV) distribution coefficients, predicted that U(IV) remained in the aqueous product stream, which is contrary to the experimental measurements

Correlation functions for the distribution coefficients of U(IV) and Pu(III) ions between aqueous nitric acid and 30% TBP in an aliphatic diluent

Energy Technology Data Exchange (ETDEWEB)

Geldard, J.F.; Beyerlein, A.L.; Phillips, L.

1985-09-01

Distribution coefficient correlations for U(IV) and Pu(III) are obtained in terms of a modified form of the total nitrate ion salting strength that was successfully used to obtain distribution coefficient correlations for U(VI) and Pu(IV) in the earlier work of G.L. Richardson. The modification of salting strength was needed to account for the fact that the U(IV) distribution coefficients measured under conditions where U(VI) is present consistently fall below those obtained when it is absent. The correlations were incorporated into the mixer-settler computer model PUBG, and in the simulation of a 20-stage 1B partitioning contactor, calculated product stream concentrations were in excellent agreement with experiment. Earlier mixer-settler computer models, which failed to account for U(IV) distribution coefficients, predicted that U(IV) remained in the aqueous product stream, which is contrary to the experimental measurements.

Medienpädagogik und die Digitale Gesellschaft im Spannungsfeld von Regulierung und Teilhabe

Directory of Open Access Journals (Sweden)

Stefan Iske

2014-12-01

Full Text Available Vor 25 Jahren stellte Tim Berners-Lee sein Konzept eines World Wide Web (WWW vor und legte damit einen der bedeutendsten Grundsteine der digitalen Vernetzung. Was ursprünglich zum Austausch von Informationen und Daten unter Forschenden entworfen wurde, hat sich zu einem umfassenden Kultur- und Bildungsraum entwickelt und ist ein universaler und zentraler Dienst des Internet geworden. Dieser gegenwärtige Status des Internet und des World Wide Web ist der vorläufige Zwischenstand einer historischen Entwicklung, der sowohl Transformationen und Veränderungen als auch Konstanten zugrunde liegen. Nicht erst zum diesjährigen Geburtstag des World Wide Web wird deutlich, dass durch digitale und vernetzte Technologien zentrale Kategorien wie Bildung, Erziehung und Sozialisation berührt werden. Beispielhaft kann auf die aktuellen Debatten über Regulierungsmechanismen im Internet wie auch auf die Enthüllungen Edward Snowdens hingewiesen werden. Aus dem Vorangehenden lassen sich medienpädagogische Fragestellungen ableiten, die zum Beispiel die Handlungsautonomie von Subjekten sowie Möglichkeitsräume der Mitgestaltung von und Teilhabe an Gesellschaft (Winter 2012, Swertz 2014 thematisieren. Zudem sind es Fragen der Mediensozialisation und der Konstruktion von Identität in digital vernetzten Räumen (Jörissen/Marotzki 2008, die sowohl bei der Theoriebildung als auch im Rahmen medienpädagogischer Praxis eine hohe Relevanz besitzen.

Thermodynamik grundlagen und technische anwendungen

CERN Document Server

Baehr, Hans Dieter

2009-01-01

Für die aktualisierte 14. Auflage des bewährten Lehrbuchs der Technischen Thermodynamik wurde das Kapitel über Wärmekraftanlagen gründlich bearbeitet und durch einen Abschnitt zur Energiewandlung ergänzt: Die Energiebedarfsstruktur von Deutschland wird erläutert, und die möglichen Energiewandlungspfade werden diskutiert. Schwerpunkt des Buches ist die ausführliche und auch dem Anfänger verständliche Darstellung der Grundlagen der Thermodynamik mit der sorgfältigen Einführung der thermodynamischen Begriffe und den fundamentalen Bilanzgleichungen für Energie, Entropie und Exergie. Die thermodynamischen Eigenschaften reiner Fluide und fluider Gemische werden eingehend erläutert. Darauf aufbauend wird die Thermodynamik der Gemische und der chemischen Reaktionen entwickelt. Auch die thermodynamischen Aspekte wichtiger energie- und verfahrenstechnischer Anwendungen werden praxisnah behandelt: - Strömungs- und Arbeitsprozesse, - thermische Stofftrennverfahren, - Verbrennungsprozesse und Verbrennungsk...

Zur historischen Aufarbeitung und medialen Vermittlung der Shoah in Italien und Deutschland

Directory of Open Access Journals (Sweden)

Peter Kuon

2016-03-01

Full Text Available Claudia Müller, Patrick Ostermann und Karl-Siegbert Rehberg, Hrsg., Die Shoah in Geschichte und Erinnerung: Perspektiven medialer Vermittlung in Italien und Deutschland (Bielefeld: transcript, 2015.

GILT - A randomised phase III study of oral vinorelbine and cisplatin with concomitant radiotherapy followed by either consolidation therapy with oral vinorelbine and cisplatin or best supportive care alone in stage III non-small cell lung cancer

Energy Technology Data Exchange (ETDEWEB)

Flentje, Michael [University Hospital Wuerzburg, Dept. of Radiotherapy, Wuerzburg (Germany); Huber, Rudolf M. [University Hospital Munich, Member of the German Center for Lung Research (DZL CPC-M), Munich (Germany); Engel-Riedel, Walburga [University Hospital Merheim, Dept. of Pneumonology, Cologne (Germany); Andreas, Stefan [Dept. of Pneumonology, Immenhausen (Germany); Kollmeier, Jens [Helios Emil-von-Behring Hospital, Berlin (Germany); Staar, Susanne [Municipal Hospital Bremen-Mitte, Bremen (Germany); Dickgreber, Nicolas [University Hospital Hannover, Hannover (Germany); Vaissiere, Nathalie; Almeida, Cecilia de [Institut de Recherche Pierre Fabre, Boulogne (France); Edlich, Birgit [Pierre Fabre Pharma GmbH, Freiburg (Germany); Fietkau, Rainer [University Hospital Erlangen, Erlangen (Germany)

2016-04-15

widerspruechliche Ergebnisse. In dieser Phase-III-Studie wurde CRT mit anschliessender ''best supportive care'' (BSC) oder Konsolidierung mit oralem Vinorelbin und Cisplatin bewertet. Die Patienten wurden mit 2 Zyklen oralem Vinorelbin (50 mg/m{sup 2}, Tag 1, 8 und 15) + Cisplatin (20 mg/m{sup 2}, Tag 1-4) q4w + Radiotherapie (RT, 66 Gy) behandelt. Patienten, die mindestens eine Krankheitskontrolle aufwiesen, wurden zu 2 Zyklen oralem Vinorelbin (60-80 mg/m{sup 2}, Tag 1 und 8) + Cisplatin (80 mg/m{sup 2}, Tag 1) q3w mit BSC oder alleiniger BSC randomisiert. Primaerer Endpunkt war das progressionsfreie Ueberleben (PFS). Fuer die CRT wurden 279 Patienten eingeschlossen und 201 Patienten fuer CC oder BSC randomisiert. CRT und CC wurden jeweils gut vertragen und wiesen wenige Faelle von strahlenbedingten Grad-3/4-Toxizitaeten (CRT/CC/BSC: oesophagitisassoziierte Ereignisse 12,9 %/3,1 %/0 %, G3-Pneumonitis 0 %/0 %/2 %) und chemotherapiebedingte Grad-3/4-Toxizitaeten [CRT/CC: Neutropenie 11,2 %/22,1 %, Leukopenie 18,3 %/26,7 %; Uebelkeit 5,0 %/2,3 % (G3), Erbrechen 3,2 %/3,5 % (G3)] auf. Im CC- und BSC-Arm betrug das mediane PFS vom Zeitpunkt der Randomisierung jeweils 6,4 (5,0-8,7) bzw. 5,5 (3,8-7,4) Monate [Hazard Ratio (HR) 0,93 (0,69-1,26); p = 0,63] und das mediane Ueberleben (OS) 20,8 (13,5-25,3) bzw. 18,5 (13,6-24,7) Monate. CC nach simultaner CRT fuehrte nicht zu einer Verlaengerung des PFS oder OS. Simultane RT mit oralem Vinorelbin und Cisplatin wies ein vorteilhaftes Sicherheitsprofil auf und stellt damit ein geeignetes Behandlungsregime fuer NSCLC-Patienten mit inoperablem Stadium III dar. (orig.)

Synthese und Charakterisierung wasserfreier Seltenerdmetall-Nitrate, -Acetate und -Oxyacetate

OpenAIRE

Heinrichs, Christina

2013-01-01

Durch thermische Entwässerung der Seltenerdmetall(SE)-Nitrat-Hydrate und der SE-Acetat-Hydrate im Argon-Strom/Vakuum konnten wasserfreie SE-Nitrate und SE-Nitrat-Monohydrate bzw. wasserfreie SE-Acetate erhalten werden. Es gelang zudem, SE-Oxyacetate durch thermische Zersetzung der SE-Acetate darzustellen. Des Weiteren wurde beim Erhitzen von Praseodym-Carbonat-Hydrat ein Pr-Carbonat-Hydroxid erhalten. Die Verbindungen wurden mittels Röntgenpulverdiffraktometrie und an ausgewählten Beispielen ...

Recht und Rechtssystem als globale Struktur und Medium der Verhaltensorientierung / Raul Narits

Index Scriptorium Estoniae

Narits, Raul, 1952-

2008-01-01

Äratr.: Multiple Modernität, Globalisierung der Rechtsordnung und Kommunikationsstruktur der Rechtssysteme : Internationales Symposium zur Theorie der Rechtskommunikation an der Universität Tartu im April 2006 ; II. Sonderheft Estland. Berlin, 2008, lk. 219-238. - (Rechtstheorie : Zeitschrift für Logik und Juristische Methodenlehre, Rechtsinformatik, Kommunikationsforschung, Normen- und Handlungstheorie, Soziologie und Philosophie des Rechts ; Bd. 38, 2007, H. 2/3)

Lexikon Schulpraxis Theorie- und Handlungswissen für Ausbildung und Unterricht

CERN Document Server

Homberger, Dietrich

2003-01-01

Das Lexikon Schulpraxis wendet sich an Lehrerinnen und Lehrer, die gezielt Fragen zu einem pädagogischen oder schulischen Sachthema klären oder ohne großen Aufwand eine knappe, präzise Information zu einem entsprechenden Stichworterhalten wollen. Die zahlreichen Querverweise ermöglichen darüber hinaus die Erschließung größerer thematischer Zusammenhänge. Insbesondere kann das Lexikon Schulpraxis von Lehrerinnen und Lehrern in der Ausbildung sowie von Berufsanfängern genutzt werden; es erschließt die Berufsfunktionen, gibt Hinweise zur Organisation und Verwaltung im Schulalltag, zu den Dienstpflichten und Vorschriften, es sichert die allgemeinen didaktischen und methodischen Grundlagen des Fachunterrichts, bietet rasche Orientierung sowie Hilfen bei der Vorbereitung und Reflexion des eigenen Unterrichts. Das Lexikon Schulpraxis hat stets das praktische Informationsinteresse eines Kollegen oder einer Kollegin im Blick. Besonders geachtet wurde auf eine verständliche Sprachgestaltung, auf erläuter...

[Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung : Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen : Stadt, Land und Konfession 1500-1721. Teil 4. Hrsg. von Matthias Asche, Werner Buchholtz und Anton Schindlin

Index Scriptorium Estoniae

Maasing, Madis, 1984-

2013-01-01

Arvustus: Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung : Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen : Stadt, Land und Konfession 1500-1721. Teil 4. (Katholisches Leben und Kirchenreform im Zeitalter der Glaubensspaltung, 72). Hrsg. von Matthias Asche, Werner Buchholtz und Anton Schindling. Verlag Aschendorff. Münster 2012

Molekulargenetische Studie zur Verbreitung und Interaktion von PCV-2 bei Haus- und Wildschweinen

OpenAIRE

Bronnert, Bastian Balthasar Marcel

2014-01-01

Im Rahmen der vorliegenden Arbeit wurden Wild- und Hausschweingewebeproben aus den Jahren 2005 bis 2008 mittels nested PCR auf das Vorkommen von PCV-2 untersucht und die positiv getesteten Proben mittels Realtime PCR quantifiziert. Zusätzlich wurden die Proben im Institut für Pathologie der Justus-Liebig-Universität histologisch und immunhistologisch untersucht (Dissertation Hohloch). Ziel war es das Vorkommen von PCV-2 und die Häufigkeit von PCV-2 assoziierter Erkankungen bei Haus- und Wilds...

Osteoporose und Laktoseintoleranz

Directory of Open Access Journals (Sweden)

Obermayer-Pietsch B

2008-01-01

Full Text Available Laktosemalabsorption oder Laktoseintoleranz ist eine symptomatische Unverträglichkeit von Milchzucker (Laktose, zumeist aufgrund einer autosomal rezessiv erblichen, irreversiblen Abnahme des Enzyms Laktase im Jugendalter, die bei etwa der Hälfte der Weltbevölkerung auftritt. Die Betroffenen meiden oft instinktiv Milch und Milchprodukte wegen der damit verbundenen Malabsorptions-Symptome. Damit scheiden diese Nahrungsmittel aber auch als Kalziumlieferanten aus und es kann zu einer Mangelversorgung des Knochens mit Kalzium und damit zu Osteoporose kommen. Da in Österreich etwa 20–25 % der Bevölkerung betroffen sind, ist diese Stoffwechselveränderung nicht zu vernachlässigen. Diagnostische und begleitende ernährungsmedizinische Maßnahmen und gegebenenfalls eine osteotrope Therapie sollten zum Erhalt der Knochenmasse eingesetzt werden.

PHP und MySQL der Web-Baukasten fur Einsteiger und Individualisten

CERN Document Server

Damaschke, Giesbert

2015-01-01

Sie haben schon eigene Webseiten gebaut und mochten diese nun mit Funktionen ausstatten, fur die Sie PHP und MySQL benotigen? Giesbert Damaschke zeigt Ihnen in diesem Buch, wie Sie das schaffen. Schritt fur Schritt erlernen Sie die benotigten Programmier- und Datenbankgrundlagen - immer im Rahmen von typischen dynamischen Anwendungen. So erheben und speichern Sie zum Beispiel mit Formularen Kontaktdaten, prufen Benutzereingaben, erstellen Menus, richten einen Besucherzahler ein, verschicken E-Mails mit PHP oder entwickeln sogar einen eigenen Blog. Alle Codebeispiele werden ausfuhrlich erklart,

Steuern und Governance

Directory of Open Access Journals (Sweden)

Eduard Müller

2014-05-01

Full Text Available ENGLISH: Taxation, in the modern state, has long been a mass phenomenon with an interdisciplinary outlook. On the macro level of the state, a new generation of administrative reforms has crystallized under the label “good public governance”. These reforms seek to resolve regulatory interdependence of state and non - state actors by way of cooperation and interaction. In parallel, on the micro level of businesses, “corporate governance” – voluntary compliance with legal and ethical standards – has become an increasingly important issue. With a view to tax law and tax collection, these developments open up new possibilities to raise tax compliance by means of consensual and cooperative instruments and, accordingly, address taxation as a mass phenomenon. DEUTSCH: Besteuerung ist im modernen Staat ein Massenphänomen und längst interdisziplinär ausgerichtet. Auf der Makro-Ebene des Staates hat sich unter dem Begriff Good Public Governance eine neue Generation von Staats- und Verwaltungsreformen herausgebildet, die Regelungsbeziehungen von staatlichen und nichtstaatlichen Akteuren durch Kooperationen und Interaktionen zu lösen versucht. Parallel dazu hat auf der Mikro-Ebene der Unternehmen mit dem Thema Corporate Governance die freiwillige Einhaltung von rechtlichen und ethischen Regeln an Bedeutung gewonnen. Für das Steuerrecht und den Steuervollzug resultieren aus diesen Entwicklungen neue Möglichkeiten, durch Nutzung konsens- und kooperationsorientierter Instrumente die Tax Compliance zu erhöhen und so dem Massenphänomen Besteuerung gerecht zu werden.

Predictive and prognostic value of tumor volume and its changes during radical radiotherapy of stage III non-small cell lung cancer. A systematic review

Energy Technology Data Exchange (ETDEWEB)

Kaesmann, Lukas [University of Luebeck, Department of Radiation Oncology, Luebeck (Germany); Niyazi, Maximilian; Fleischmann, Daniel [LMU Munich, Department of Radiation Oncology, Munich (Germany); German Cancer Consortium (DKTK), partner site Munich, Munich (Germany); German Cancer Research Center (DKFZ), Heidelberg (Germany); Blanck, Oliver; Baumann, Rene [University Medical Center Schleswig-Holstein, Department of Radiation Oncology, Kiel (Germany); Baues, Christian; Klook, Lisa; Rosenbrock, Johannes; Trommer-Nestler, Maike [University Hospital of Cologne, Department of Radiotherapy, Cologne (Germany); Dobiasch, Sophie [Technische Universitaet Muenchen, Department of Radiation Oncology, Munich (Germany); Eze, Chukwuka [LMU Munich, Department of Radiation Oncology, Munich (Germany); Gauer, Tobias; Goy, Yvonne [University Medical Center Hamburg-Eppendorf, Department of Radiotherapy and Radio-Oncology, Hamburg (Germany); Giordano, Frank A.; Sautter, Lisa [University Medical Center Mannheim, Department of Radiation Oncology, Mannheim (Germany); Hausmann, Jan [University Medical Center Duesseldorf, Department of Radiation Oncology, Duesseldorf (Germany); Henkenberens, Christoph [Hannover Medical School, Department of Radiation and Special Oncology, Hannover (Germany); Kaul, David; Thieme, Alexander H. [Charite School of Medicine and University Hospital, Campus Virchow-Klinikum, Department of Radiation Oncology, Berlin (Germany); Krug, David; Schmitt, Daniela [University Hospital Heidelberg and National Center for Radiation Research in Oncology (NCRO) and Heidelberg Institute for Radiation Oncology (HIRO), Department of Radiation Oncology, Heidelberg (Germany); Maeurer, Matthias [University Medical Center Jena, Department of Radiation Oncology, Jena (Germany); Panje, Cedric M. [Kantonsspital St. Gallen, Department of Radiation Oncology, St. Gallen (Switzerland); Suess, Christoph [University Medical Center Regensburg, Department of Radiation Oncology, Regensburg (Germany); Ziegler, Sonia [University Medical Center Erlangen, Department of Radiation Oncology, Erlangen (Germany); Ebert, Nadja [University Medical Center Dresden, Department of Radiation Oncology, Dresden (Germany); OncoRay - National Center for Radiation Research in Oncology, Dresden (Germany); Medenwald, Daniel [Martin Luther University Halle-Wittenberg, Department of Radiation Oncology, Faculty of Medicine, Halle (Germany); Ostheimer, Christian [Martin Luther University Halle-Wittenberg, Department of Radiation Oncology, Faculty of Medicine, Halle (Germany); Klinik und Poliklinik fuer Strahlentherapie, Universitaetsklinikum Halle (Saale) (Germany); Collaboration: Young DEGRO Trial Group

2018-02-15

. Several potential confounding variables were found and need to be considered for future studies to evaluate GTV changes during definitive radiotherapy with respect to treatment outcome. (orig.) [German] Das Bronchialkarzinom ist die haeufigste Ursache krebsbedingter Mortalitaet weltweit. Das Stadium III des nicht-kleinzelligen Bronchialkarzinoms (NSCLC) praesentiert sich als heterogene Patientengruppe mit Lymphknotenbeteiligung und grossen Tumoren mit Infiltration von Mediastinum, Herz und Wirbelsaeule. Ein interdisziplinaeres Behandlungskonzept mit Strahlentherapie ist Therapiestandard in der Behandlung des Stadium III mit akzeptabler Toxizitaet und verbessertem klinischen Ergebnis hinsichtlich lokaler Kontrolle. Veraenderungen des Tumorvolumens (GTV) unter Strahlentherapie ermoeglichen eine adaptive Bestrahlungsplanung mit Normalgewebeschonung und Dosiseskalation. Durchgefuehrt wurde eine Literaturrecherche zum praediktiven Wert von GTV-Veraenderungen unter Strahlentherapie mit dem Endpunkt ''Gesamtueberleben''. Die Recherche wurde in einem zweistufigen Verfahren unter Verwendung von Medline/Pubmed mit den Stichwoertern ''stage III non-small cell lung cancer'' und ''radiotherapy'' und ''tumour volume'' und ''prognostic factors'' durchgefuehrt. Nach finaler Bewertung blieben 17, 14 und 9 Studien mit 2516, 784 und 639 Patienten zum praediktiven Einfluss von GTV, GTV-Veraenderung und dessen Einfluss auf das Gesamtueberleben uebrig und wurden in den Review aufgenommen. Das initiale GTV war in verschiedenen Studien ein wichtiger prognostischer Faktor fuer das Gesamtueberleben. Zeitpunkt der Evaluation und Einfluss der Histologie muessen jedoch weiter untersucht werden. GTV-Veraenderungen unter Strahlentherapie variieren sehr. Der optimale Zeitpunkt fuer eine Reevaluation des GTVs fuer den praediktiven Wert auf die Prognose ist unklar. Der prognostische Wert von GTV

Computerspielgewalt und Aggression: Längsschnittliche Untersuchung von Selektions- und Wirkungseffekten

OpenAIRE

Staude-Müller, Frithjof

2011-01-01

Auf Grundlage sozialkognitiver Aggressionsmodelle wurde die Beziehung zwischen Computerspielgewohnheiten und der Aggressionsneigung sowie Verzerrungen in der sozialen Informationsverarbeitung untersucht. Dazu wurden 499 Schüler/innen weiterführender Schulen (6.-8. Kl. Gymnasium, Haupt- und Realschule) in zwei Erhebungen mit einem Intervall von einem Jahr befragt. Mit hierarchischen Regressionsanalysen wurden Wirkungs- und Selektionseffekte geprüft, wobei relevante Drittvariablen (Monitoring u...

[Sascha Möbius. Das Gedähtnis der Reichsstadt. Unruhen und Kriege in der lübeckischen Chronistik und Kriege und Erinnerungskultur des späten mittelalters und der frühen Neuzeit

Index Scriptorium Estoniae

Hormuth, Dennis

2012-01-01

Arvustus: Sascha Möbius. Das Gedähtnis der Reichsstadt. Unruhen und Kriege in der lübeckischen Chronistik und Kriege und Erinnerungskultur des späten mittelalters und der frühen Neuzeit. (Göttingen, 2011)

Characterization of the chemical composition of PM2.5 emitted from on-road China III and China IV diesel trucks in Beijing, China.

Science.gov (United States)

Wu, Bobo; Shen, Xianbao; Cao, Xinyue; Yao, Zhiliang; Wu, Yunong

2016-05-01

The composition of diesel exhaust fine particulate matter (PM2.5) is of growing interest because of its impacts on health and climatic factors and its application in source apportionment and aerosol modeling. We characterized the detailed chemical composition of the PM2.5, including the organic carbon (OC), elemental carbon (EC), water-soluble ions (WSIs), and elemental contents, emitted from China III and China IV diesel trucks (nine each) based on real-world measurements in Beijing using a portable emissions measurement system (PEMS). Carbonaceous compounds were the dominant components (totaling approximately 87%) of the PM2.5, similar to the results (greater than 80% of the PM2.5) of our previous study of on-road China III diesel trucks. In general, the amounts of individual component groups (carbonaceous compounds, WSIs, and elements) and PM2.5 emissions for China IV diesel trucks were lower than those of China III diesel trucks of the same size, except for the WSIs and elements for the light- and medium-duty diesel trucks. The EC/OC mass ratios were strongly dependent on the emission standards, and the ratios of China IV diesel trucks were higher than those of China III diesel trucks of the same size. The chemical species in the PM2.5 were significantly affected by the driving conditions. Overall, the emission factors (EFs) of the PM2.5 and OC under non-highway (NHW) driving conditions were higher than those under highway (HW) driving conditions, and the EC/OC mass ratios presented an increasing trend, with decreasing OC/PM2.5 and increasing EC/PM2.5 from NHW to HW driving conditions; similar trends were reported in our previous study. In addition, Pearson's correlation coefficients among the PM2.5 species were analyzed to determine the relationships among the various chemical components. Copyright © 2016 Elsevier B.V. All rights reserved.

Von Nischen und Infrastrukturen - Herausforderungen und neue Ansätze politischer Technologien

Directory of Open Access Journals (Sweden)

Felix Stalder

2011-06-01

Full Text Available Neue Technologien aus dem aktivistischen Umfeld bieten radikale Alternativen zu kultureller Nischenbildung und zentralisierten Web 2.0-Infrastrukturen. Die sozialen und politischen Realitäten der Digitalisierung und Vernetzung sind heute von zwei konstitutiven, aber grundsätzlich unterschiedlichen, ja teilweise sogar entgegengesetzten Dynamiken geprägt. Beide stellen den Medienaktivismus vor neue Herausforderungen. Zum einen können wir ein Aufblühen neuer kultureller Nischen und horizontaler Organisationsformen beobachten. Zum anderen erleben wir gleichzeitig eine enorme Zentralisierung und Konzentration auf der Ebene der Plattformen, welche einen grossen Teil der infrastrukturellen Grundlage des Wachstum der Nischen und neuen Kooperationsmuster darstellen. Nachdem der Aufbau alternativer Infrastrukturen – Zeitschriften, TV Kanäle und Internetplattformen – in den ersten 30 Jahren medienaktivistischer Projekte eine grosse Rolle gespielt hat (Stalder 2008 sind diese Fragen in den letzten 10 Jahren etwas in den Hintergrund getreten. Denn die Komplexität der Infrastrukturen nahm stetig zu, was es immer aufwendiger machte, sie zu betreiben und die neuen, offene Plattformen, wie sie für Web 2.0 typisch sind, stellten allen - scheinbar ohne Einschränkungen - mächtige Werkzeuge zu Verfügung. Warum eine eigene Plattform betreiben, wenn grosse professionelle Anbieter das besser, sicherer und kostenfrei anbieten? Heute sind die Probleme dieser Entwicklungen aber deutlich zu erkennen. Im Folgenden werden die Herausforderungen dieser Nischenbildung, die dunkle Seite der zentralisierten Infrastrukturen sowie die darauf reagierenden, neue Entwürfe für de-zentrale Infrastrukturen skizziert.

Rudolf Streinz. Meinungs- und Informationsfreiheit zwischen Ost und West / Henn-Jüri Uibopuu

Index Scriptorium Estoniae

Uibopuu, Henn-Jüri, 1929-2012

1983-01-01

Tutvustus: Streinz, Rudolf. Meinungs- und Informationsfreiheit zwischen Ost und West : Möglichkeiten und Grenzen intersystemarer völkerrechtlicher Garantien in einem systemkonstituierenden Bereich. Ebelsbach : Rolf Gremer, 1981

Cyberbullying und Empathie : affektive, kognitive und medienbasierte Empathie im Kontext von Cyberbullying im Kindes- und Jugendalter

OpenAIRE

Pfetsch, Jan; Müller, Christin R.; Ittel, Angela

2014-01-01

"Bei medial vermittelter Kommunikation sinkt sowohl die Hemmschwelle für aggressive Verhaltensweisen wie Cyberbullying als auch die Wahrscheinlichkeit empathischer Reaktionen. Im Fokus der vorliegenden Studie mit 979 Schülerinnen und Schülern der 4.-8. Klassen (M=12.01, SD=1.68 Jahre, 55% weiblich) stand die Frage, ob Cyberbullies geringere Ausprägungen für affektive, kognitive und medienbasierte Empathie aufweisen als Unbeteiligte. Empathie wurde im Selbst- und Peerbericht erhoben. Hypothese...

Teilchendetektoren Grundlagen und Anwendungen

CERN Document Server

Kolanoski, Hermann

2016-01-01

In diesem Buch werden die experimentellen Grundlagen von Teilchendetektoren und ihre Anwendung in Experimenten beschrieben. Die Entwicklung von Detektoren ist ein wichtiger Bestandteil der Teilchen-, Astroteilchen- und Kernphysik und gehört daher zum Handwerk des Experimentalphysikers in diesen Gebieten. Dieses umfassende Werk beinhaltet den kompletten Stoff für entsprechende Master-Module in der experimentellen Teilchenphysik, geht aber im Inhalt auch darüber hinaus. Zielgruppe sind Studierende, die sich in die Materie vertiefen möchten, aber auch Lehrende und Wissenschaftler, die das Buch zum Einstieg in das wissenschaftliche Arbeiten an Detektorentwicklungen verwenden können. Zielrichtung des Buches ist, die physikalischen Grundlagen für die Detektoren und ihrer verschiedenen Ausführungen so klar wie möglich und so tiefgehend wie nötig darzustellen. Die Breite des für die Detektorentwicklung nötigen Wissens umfasst viele Bereiche der Physik und Technik, von den Wechselwirkun...

Aussteigen aus dem Rechtsextremismus: Foto-Praxis, bildwissenschaftliche Analyse und Ausstellungsarbeit als Methoden individueller Reflexion und des wissenschaftlichen und (sozialpädagogischen Kompetenzerwerbs

Directory of Open Access Journals (Sweden)

Ulrike Pilarczyk

2013-06-01

Full Text Available Der Beitrag zeigt die medienpädagogischen und bildwissenschaftlichen Dimensionen eines zeitlich und thematisch gestaffelten Projektes auf. Ausgangspunkt war das in den Jahren 2009/10 von der Organisation EXIT-Deutschland in Berlin mit Aussteigern/-innen aus der rechtsextremen Szene initiierte Fotoprojekt «Lebensbilder». Die im Rahmen biografisch orientierter, medien- und sozialpädagogischer Fallarbeit entstandenen Fotos wurden als Prozess individueller Bilderzeugung und als Mittel zur Reflexion der jeweiligen Lebenssituation der Aussteiger(innen verstanden und eingesetzt. Eine Ausstellung schloss diese erste Phase des hier beschriebenen Projektes ab. Dem Wunsch folgend, die praktischen Erfahrungen aus der Arbeit mit Fotos wissenschaftlich überprüfen zu lassen, wurden in den Jahren 2011 und 2012 mit Studierenden am erziehungswissenschaftlichen Institut der TU Braunschweig die «Lebensbilder» zunächst einer wissenschaftlichen Bildanalyse unterzogen und anschliessend in einem gestalterisch-interpretativen Projekt durch die Studierenden zu einer Ausstellung weiterentwickelt.

Behaviour of Pu-IV with various ion exchangers in solutions containing nitric acid and oxalates

International Nuclear Information System (INIS)

Walter, E.; Ali, S.A.

1982-02-01

The distribution of Pu-IV on the ion exchangers Dowex 50W-X8, Dowex 1-X8 und Dowex Chelating Resin Al-X8 in the presence of various concentrations of nitric acid and oxalate were investigated. The results indicate that nitric acid and oxalic acid influence each other during complexation of Pu-IV with oxalate ions solutions containing nitric acid it is not possible to neglect the formation of Pu-IV nitrate complexes. The complex Pu(IV) (C 2 O 4 ) 3 2 - only is formed in solutions containing low nitric acid and high oxalic acid concentrations. The separation of Pu-IV in Dowex Chelating Resin from nitric acid solution in the presence of higher oxalate concentrations is possible, provided that the nitric acid concentration is lower than 0.25 molar [fr

Electronic structure and lattice properties of metastable III-(N,V) semiconductor systems; Elektronische Struktur und Kristallgittereigenschaften von metastabilen III-(N,V)-Halbleitersystemen

Energy Technology Data Exchange (ETDEWEB)

Guengerich, M.

2007-12-18

This thesis gives an overview of these influences for Ga-V semiconductors (V=P,As,Sb). Lattice vibrations of the ternary alloys Ga(N,P), Ga(N,As) und Ga(N,Sb) are studied and analyzed with respect to the local binding of the N atoms in the host lattices. For the first time, pressure coefficients of the extended host phonons as well as of the N local vibrational modes in Ga(N,As) und Ga(N,P) are determined by Raman spectroscopy under hydrostatic pressure. The relationship between the force constant of the Ga-N bond and the bond length is determined. A central aspect of the thesis is the concentration dependence of optical transitions in Ga(N,P) and Ga(N,As), studied by spectroscopic methods. The impurity levels in both materials are determined by the spatial statistics of the N atoms. (orig.)

Informationskompetenz und Information Literacy

OpenAIRE

Ingold, Marianne

2012-01-01

Informationskompetenz ist heute als Begriff , Konzept und praktisches Tätigkeitsfeld von Bibliotheken weltweit etabliert. Entstehung, Verbreitung und Entwicklung von „Informationskompetenz“ im deutschsprachigen Raum stehen in engem Zusammenhang mit dem in den USA und international seit den 1980er Jahren diskutierten und praktisch umgesetzten Konzept der „Information Literacy“. Auch wenn die beiden Begriffe in der Regel gleichbedeutend verwendet werden, zeigt ein Vergleich der vorwiegend aus e...

Radiotherapy for invasive thymoma and thymic carcinoma. Clinicopathological review

Energy Technology Data Exchange (ETDEWEB)

Mayer, R.; Stuecklschweiger, G.F.; Prettenhofer, U.; Stranzl, H.; Hackl, A. [Univ. Graz (Austria). Dept. of Radiotherapy; Beham-Schmid, C. [Univ. Graz (Austria). Dept. of Pathology; Groell, R. [Univ. Graz (Austria). Dept. of Radiology; Smolle-Juettner, F.M.; Renner, H. [Univ. Graz (Austria). Dept. of Thoracic and Hyperbaric Surgery; Quehenberger, F. [Univ. Graz (Austria). Dept. of Medical Informatics, Statistics and Documentation

1999-06-01

All 33 patients were irradiated with a mean dose of 50 Gy after complete resection (16 patients), partial resection (9 patients) of biopsy (8 patients). Staging was done according to the Masaoka classification; there were 12 Stage II, 12 Stage III and 9 Stage IV patients. Results: In patients with invasive thymoma Stage II to IV (median follow-up 54.4 months) Kaplan-Meier estimates of overall survival (OS), disease-specific (DSS) and disease-free survival (DFS) at 5 years were 63.7% (95% confidence interval [CI], 42 to 84%), 88.3% (CI, 75 to 100%) and 77,4% (CI, 58 to 95%), respectively. Among the prognostic factors tested, such as age, myasthenia gravis, completeness of surgery and histologic subclassification, total radiation dose, and Masaoka Stage, the latter was the only significant predictor of improved survival (p=0.04). Considering local control, radiation dose was a significant prognostic factor (p=0.0006). In patients with thymic carcinoma (median follow-up 43.4 months) 5 year DSS, and DFS were 22.2% (CI, 0 to 60%) and 16.7% (CI, 0 to 46%), respectively. Thymoma as compared to thymic carcinoma had a statistically significant better DSS (p=0.007) and DFS (p=0.0007). Conclusion: Postoperative radiotherapy with sufficient doses plays an important role as adjuvant treatment in complete or incomplete resected invasive Stage II to III thymoma. In unresectable thymoma Stage III to IV as well as in thymic carcinoma a multimodality approach should be considered to improve survival. (orig.) [Deutsch] Alle 33 Patienten wurden nach kompletter Resektion (n=16), Teilresektion (n=9) oder Biopsie (n=8) mit einer mittleren Dosis von 50 Gy (30 bis 60 Gy) bestrahlt. Die Stadieneinteilung nach Masaoka ergab jeweils zwoelf Patienten in Stadium II und III sowie neun Patienten im Stadium IV. Ergebnisse: Patienten mit einem invasivem Thymom Masaoka-Stadium II bis IV (mediane Nachsorgezeit 54,4 Monate) hatten ein Fuenf-Jahres-Gesamtueberleben, krankheitsspezifisches und

Der Nahostkonflikt und die Medien

Directory of Open Access Journals (Sweden)

Carola Richter

2014-06-01

Full Text Available Diese Einführung in eine Themenausgabe zu den vielfältigen Rollen der Medien im Nahostkonflikt skizziert die Probleme, die sich für Medien und Journalisten als Akteure im Konflikt, Adressaten der Konfliktparteien und Anlass für Konflikt durch ihre Berichterstattung ergeben. Das Konfliktgebiet Israel und Palästina ist sowohl für Forschung über Auslandsbericht-erstattung, über transnationale Agenda Building- und Public Diplomacy-Prozesse als auch über mediensystemische Entwicklungen in Besatzer- und Besatzungsgebieten interessant. Der Artikel gibt einen Überblick über das Feld und führt dabei in die in der Themenausgabe präsentierten empirischen Studien zum Nahostkonflikt und den Medien ein.

A fresnoite-structure-related mixed valent titanium(III/IV) chlorosilicate, Ba{sub 3}Ti{sub 2}Si{sub 4}O{sub 14}Cl: A flux crystal growth route to Ti(III) containing oxides

Energy Technology Data Exchange (ETDEWEB)

Abeysinghe, Dileka; Smith, Mark D.; Loye, Hans-Conrad zur, E-mail: zurloye@mailbox.sc.edu

2017-06-15

Single crystals of mixed valent barium titanium(III/IV) chlorosilicate, Ba{sub 3}Ti{sub 2}Si{sub 4}O{sub 14}Cl{sub 0.91}O{sub 0.09}, were grown in a high temperature molten chloride flux involving an in situ reduction step. The fresnoite structure related Ba{sub 3}Ti{sub 2}Si{sub 4}O{sub 14}Cl{sub 0.91}O{sub 0.09} crystallizes in the tetragonal space group P4/mbm with lattice parameters of a=8.6717(2) Å, c=18.6492(5) Å. The title compound exhibits a 3D structure consisting of 2D layers of fused Ti{sub 2}O{sub 9} and Si{sub 4}O{sub 12} groups and 2D layers of fused Ti{sub 2}O{sub 9}Cl{sub 2} and Si{sub 2}O{sub 7} groups that are linked via barium atoms. The in situ reduction of Ti(IV) to Ti(III) is achieved via the addition of metallic Mg to the flux to function as the reducing agent. The temperature dependence of the magnetic susceptibility shows simple paramagnetism above 100 K. There is a discontinuity in the susceptibility data below 100 K, which might be due to a structural change that takes place resulting in charge ordering. - Graphical abstract: The fresnoite structure related novel reduced barium titanium chlorosilicate, Ba{sub 3}Ti{sub 2}Si{sub 4}O{sub 14}Cl{sub 0.91}O{sub 0.09}, were synthesized via flux method. An in situ reduction of Ti(IV) to Ti(III) achieved using Mg metal. The 3D structure consists 2D layers of fused Ti{sub 2}O{sub 9} and Si{sub 4}O{sub 12} and 2D layers of fused Ti{sub 2}O{sub 9}Cl{sub 2} and Si{sub 2}O{sub 7} connected via barium atoms. Compound shows simple paramagnetism above 100 K. - Highlights: • The fresnoite related Ba{sub 3}Ti{sub 2}Si{sub 4}O{sub 14}Cl{sub 0.91}O{sub 0.09} were grown via molten flux method. • The in situ reduction of Ti(IV) to Ti(III) is achieved using metallic Mg. • 2D layers of Ti{sub 2}O{sub 9} and Si{sub 4}O{sub 12} and Ti{sub 2}O{sub 9}Cl{sub 2} and Si{sub 2}O{sub 7} connect via Ba atoms. • The magnetic susceptibility shows simple paramagnetism above 100 K.

75 FR 23263 - Alta Wind I, LLC; Alta Wind II, LLC; Alta Wind III, LLC; Alta Wind IV, LLC; Alta Wind V, LLC...

Science.gov (United States)

2010-05-03

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL10-62-000] Alta Wind I, LLC; Alta Wind II, LLC; Alta Wind III, LLC; Alta Wind IV, LLC; Alta Wind V, LLC; Alta Wind VI, LLC; Alta Wind VII, LLC; Alta Wind VIII, LLC; Alta Windpower Development, LLC; TGP Development Company, LLC...

Geschmackspapillendichte und Geschmackswahrnehmung bei Jugendlichen mit Essstörungen und einer gesunden Kontrollgruppe

OpenAIRE

Kaltenhofer, Alice

2009-01-01

Fragestellung Die Schmeckwahrnehmung wird u.a. über Lernprozesse, kognitive Vorgänge, genetische und biochemische Faktoren reguliert. Ess- und Diätverhalten werden durch sie beeinflusst. Den anatomisch und physiologisch ersten Abschnitt der Schmeckwahrnehmung bilden die fungiformen Geschmackspapillen. In den Geschmackspapillen liegen die Geschmacksknopsen, mit deren Hilfe die Schmeckstoffe aufgenommen und in Form von Aktionspotentialen zum Thalamus, dem limbischen System,dem Gyrus postzentral...

Kontrolle des Verwaltungsrates : eine Untersuchung der internen und externen Kontrollinstitutionen, -instrumente und -mechanismen

OpenAIRE

Reust, Dominik

2014-01-01

Eine wichtige Erkenntnis dieser Arbeit ist, dass eine effiziente und effektive Kontrolle des Verwaltungsrates nur über das Zusammenspiel der internen körperschaftlichen Kontrollinstitutionen und -instrumente mit den externen Kontrollinstitutionen und Kontrollmechanismen des Marktes erreicht wird. Die Vorschriften der VegüV betreffend transparente Entschädigungspolitik und unabhängige Stimmrechtsvertreter sowie die in der Aktienrechtsrevision angestrebte Stärkung der Informations-, Mitwirk...

Incorporation of μ3-CO3 into an MnIII/MnIV Mn12 cluster: {[(cyclam)MnIV(μ-O)2MnIII(H2O)(μ-OH)]6(μ3-CO3)2}Cl8·24H2O

Science.gov (United States)

Levaton, Ben B.; Olmstead, Marilyn M.

2010-01-01

The centrosymmetric title cluster, hexa­aquadi-μ3-carbonato-hexa­cyclamhexa-μ2-hydroxido-dodeca-μ2-oxido-hexa­mang­an­ese(IV)hexa­manganese(III) octa­chloride tetra­cosa­hydrate, [Mn12(CO3)2O12(OH)6(C10H24N4)6(H2O)6]Cl8·24H2O, has two μ3-CO3 groups that not only bridge octahedrally coordinated MnIII ions but also act as acceptors to two different kinds of hydrogen bonds. The carbonate anion is planar within experimental error and has an average C—O distance of 1.294 (4) Å. The crystal packing is stabilized by O—H⋯Cl, O—H⋯O, N—H⋯Cl and N—H⋯O hydrogen bonds. Two of the four independent chloride ions are disordered over five positions, and eight of the 12 independent water mol­ecules are disordered over 21 positions. PMID:21587382

Separation of Cr(III) from Cr(VI) by Triton X-100 cerium(IV) phosphate as a surface active ion exchanger

International Nuclear Information System (INIS)

El-Azony, K.M.; Ismail Aydia, M.; El-Mohty, A.A.

2011-01-01

Triton X-100 cerium(IV) phosphate (TX-100CeP) was synthesized and characterized by using IR, X-ray, TGA/DT and the elemental analysis. The chemical stability of TX-100CeP versus the different concentrations of HCl acid was studied before and after its exposure to the radiation dose (30 K Gray). The effect of HCl concentration on separation of Cr(III) from Cr(VI) by using TX-100CeP as surface active ion exchanger was also studied. A novel method was achieved for the quantifying of Cr(III) and Cr(VI) ions by using the high-performance liquid chromatography (HPLC) at wavelength 650 nm, a stationary phase consists of reversed phase column (Nucleosil phenyl column; 250 x 4.6 mm, 5 μm), and a mobile phase consists of 0.001 M di-(2-ethylhexyl) phosphoric acid (DEHPA) in methanol:water (70:30 v/v). The retention times were 7.0 and 8.5 min, for the Cr(III) and Cr(VI), respectively. The exchange capacity of Cr(III) was quantified (2.1 meq/g) onto the TX-100CeP. (author)

Steueroasen und Regulierungsoasen – Auswirkungen auf die Stabilität des Finanzmarkts und politische Implikationen

Directory of Open Access Journals (Sweden)

Michaela Schmidt

2012-12-01

Full Text Available In diesem Beitrag wird dargelegt, dass Steuer- und Regulierungsoasen nicht nur Steuerausfälle und Kapitalflucht ermöglichen, sondern auch eine Hauptursache für die Finanzkrise 2007/2008 waren und weiterhin die Stabilität des Finanzmarkts gefährden. Sie haben den Boden bereitet für das Aufkommen nicht regulierter Finanzinstitutionen, sogenannter Schattenbanken. Regulierungsoasen ermöglichen Finanzmarktakteuren eine Umgehung von Regulierungs- und Aufsichtsvorschriften und heizen den Wettbewerb um niedrige Regulierungsvorschriften maßgeblich an. Jeder Schritt zu einer finanzpolitischen Re-Regulierung von Steuer- und Regulierungsoasen sowie Schattenbanken ist ein aktiver Schritt zur Krisenvorbeugung und damit zum Schutz der ArbeitnehmerInnen vor den gewaltigen volkswirtschaftlichen Kosten von Finanzkrisen.

Milch, Milchprodukte, Analoge und Speiseeis

Science.gov (United States)

Coors, Ursula

Die Produktpalette Milch und Erzeugnisse aus Milch beinhaltet Konsummilch, die aus Milch oder Bestandteilen der Milch hergestellten Milcherzeugnisse wie Sauermilch-, Joghurt-, Kefir-, Buttermilch-, Sahne-, Kondensmilch-, Trockenmilch- und Molkenerzeugnisse, Milchmisch- und Molkenmischprodukte (Produkte mit beigegebenen Lebensmitteln), Milchzucker, Milcheiweißerzeugnisse, Milchfette und Käse.

Extração líquido-líquido de ferro(III e titânio(IV pelo ácido bis-(2-etil-hexil fosfórico (D2EHPA em meio de ácido sulfúrico Liquid-liquid extraction (LLE of Fe(III and Ti(IV by bis-(2-ethyl-hexyl phosphoric acid (D2EHPA in sulfuric acid medium

Directory of Open Access Journals (Sweden)

Glauco Corrêa da Silva

2008-01-01

Full Text Available This work presents a study on the separation of Fe(III and Ti(IV from sulfuric acid leaching solutions of ilmenite (FeTiO3 using liquid-liquid extraction with D2EHPA in n-dodecane as extracting agent. The distribution coefficients (K D of the elements related to free acidity and concentration of Fe(III and Ti(IV were determined. Free acidity was changed from 3x10-2 to 11.88 mol L-1 and D2EHPA concentration was fixed at 1.5 mol L-1. Recovery of final products as well as recycling of wastes generated in the process were also investigated. The LLE process as a feasible alternative to obtain high-purity TiO2.

Formation of TiO/Al2O3/C Composite in Thermal Co-decomposition of Aluminium(III) Acetylacetonate and Titanium(IV) Oxyacetylacetonate.

Czech Academy of Sciences Publication Activity Database

Kovářík, T.; Pokorná, Dana; Urbanová, Markéta; Bezdička, Petr; Bastl, Zdeněk; Kupčík, Jaroslav; Křenek, T.; Pola, M.; Kullová, L.; Pola, Josef

2016-01-01

Roč. 117, JAN 2016 (2016), s. 182-190 ISSN 0165-2370 R&D Projects: GA TA ČR TA04020860 Institutional support: RVO:67985858 ; RVO:61388980 ; RVO:61388955 Keywords : thermal co-decomposition * aluminium(III) acetylacetonate * titanium(IV) oxyacetylacetonate * titanium monoxide * alumina * Carbona Subject RIV: CF - Physical ; Theoretical Chemistry; CA - Inorganic Chemistry (UACH-T) Impact factor: 3.471, year: 2016

Arbeitszeitflexibilisierung in der westdeutschen Metall- und Elektroindustrie und die Verbandsstrategien - Eine vergleichende Analyse der arbeitszeitpolitischen Strategien des Arbeitgeberverbandes Gesamtmetall und der Industriegewerkschaft Metall

OpenAIRE

Altun, Ufuk

2005-01-01

Arbeitszeitpolitik und Arbeitszeitgestaltung haben seit dem Tarifkompromiss im Jahre 1984 in der Metall-, und Elektroindustrie in der politischen und wissenschaftlichen Diskussion einen immensen Bedeutungszuwachs erfahren. Die Forderungen nach einer flexibleren Arbeitszeitgestaltung haben zeitgleich sowohl aus der Globalisierungsdiskussion und der Debatte um die Wettbewerbsfähigkeit des "Wirtschaftsstandorts Deutschland" heraus wie auch aus beschäftigungspolitischen Gründen neuen Auftrieb bek...

Intermediale Synchronisation zwischen Volltext und Film und ihre Realisierung in Hybrideditionen

OpenAIRE

Bülow, Gilles

2017-01-01

Diese Arbeit behandelt die theoretische Erfassung und prototypische Erzeugung komplexer Musterdokumente mit synchronisiertem »Volltext« und »Bewegtbild«. Dabei werden wesentliche Randbedingungen für die Dokumentengliederung ermittelt. Diese Randbedingungen erlauben es dann, unterhalb der Plattformebene (des »reinen« Buchs und des »reinen« Films) neue multimediale Hybrideditionen auf Basis elektronischer Publikationsformate als Ausgabeplattform »sinnvoll« zu generieren. Empirisch wird der F...

"Tabula Sinvs Venetici" von W. Barents und ihre Geschichtilische und Geographische Bedeutung

Directory of Open Access Journals (Sweden)

Mithad Kozličić

1999-06-01

Full Text Available In der wissenschaftlichen Literatur sind zwei Varianten der Seekarte der Adria vom niederländischen Seefahrer und Polarforscher Willem Barents (1550-1597 bekannt. Die erste, in diesem Aufsatz als K-1 bezeichnete Karte, wurde in Amsterdam 1595 hergestellt und gedruckt. Sie hatte anfänglich eine praktisch-navigatorische Funktion. Die zweite, K-2, ins Jahr 1595 datierte (1637-1662 Karte, wurde als geostrategische Karte der Adria und der südlichen Teile Europas ausgenützt. An den adriatischen Nordküsten, besonders in ihrem Hinterland, geschahen mit dem Durchbruch der Türken seit der Hälfte des 16. Jahrhunderts wichtige militärische und politische Änderungen. In den “Atlanten” des Niederländers Jan (Johann; Joannes Janssonius (1588-1664 fehlte gerade solch eine Karte, die auch mehrmals in Amsterdam gedruckt wurde, aber zwischen 1637 und 1662. Die K-1 von Barents, deren Druckplatte Janssonius zur Verfügung hatte, konnte diese Funktion befriedigen. Deswegen machte Janssonius nur die nötigen dem darstellenden Standard der ersten Hälfte des 17. Jahrhunderts entsprechenden Änderungen, und als solche wurde sie gedruckt. Die K-2 verlor ihre ursprüngliche praktisch-navigatorische Funktion und wurde eine Karte von geostrategischer Bedeutung. Mit diesen Grundfragen befaßt sich dieser Aufsatz.

Collagen type IV at the fetal-maternal interface

OpenAIRE

Oefner, C M; Sharkey, A; Gardner, L; Critchley, H; Oyen, M; Moffett, A

2015-01-01

Introduction Extracellular matrix proteins play a crucial role in influencing the invasion of trophoblast cells. However the role of collagens and collagen type IV (col-IV) in particular at the implantation site is not clear. Methods Immunohistochemistry was used to determine the distribution of collagen types I, III, IV and VI in endometrium and decidua during the menstrual cycle and the first trimester of pregnancy. Expression of col-IV alpha chains during the reproductive cycle ...

Referenzmodelle im Mobile Business: Analyse und Entwicklung neuer Rollen, Szenarien und Geschäftsmodelle

OpenAIRE

Hufenbach, Yvonne

2016-01-01

Das digitale Zeitalter ist charakterisiert durch sich stetig wandelnde Märkte, Techniken und wirtschaftliche Voraussetzungen. Klassische Wertschöpfungsketten brechen auf und wandeln sich zu Wertschöpfungsnetzen. Dabei findet eine Neuzuordnung zwischen Wertschöpfungstätigkeiten und Marktteilnehmern statt. Diese digitale Welt ist zudem durch hohe Interdependenzen wirtschaftlicher, informationstechnischer und rechtlicher Fragestellungen gekennzeichnet. Vor diesem Hintergrund verfolgt die Arb...

Radiation therapy in old patients. Side effects and results of radiation therapy in old patients; Strahlentherapie des alten Patienten. Vertraeglichkeit und Ergebnisse der Strahlentherapie aelterer Personen

Energy Technology Data Exchange (ETDEWEB)

Geinitz, H.; Zimmermann, F.B.; Molls, M. [Klinik und Poliklinik fuer Strahlentherapie und Radiologische Onkologie, Klinikum rechts der Isar, Technische Univ. Muenchen (Germany)

1999-03-01

leads to extensive atherosclerotic vessel damage should be kept in mind. Old patients should be monitored closely during therapy, since the loss of electrolytes or fluid is often not very well tolerated. Conclusion: The indication to radiation therapy of elderly cancer patients should take into account their performance status as well as the extent and the severity of comorbidity. Age per se is seldom a contraindication for radiation therapy. Regarding the available data in literature there is no indication for a dose reduction in radiation therapy only because of age, especially in the curative setting. (orig.) [Deutsch] Hintergrund: Die Anzahl alter Patienten in der Strahlentherapie steigt mit der zunehmenden Alterung der Bevoelkerung. Dennoch werden die damit verbundenen Fragen zur Vertraeglichkeit und Effektivitaet einer Strahlenbehandlung alter Menschen selten diskutiert. Material und Methode: Die Ergebnise einer Literaturrecherche zu epidemiologischen Daten, strahlenbiologischen Aspekten und Ergebnissen der Strahlentherapie alter Patienten werden dargestellt. Ergebnisse: Mit zunehmendem Alter nimmt die Krebsinzidenz zu. Sie liegt bei Maennern aelter als 85 Jahre bei ca. 3,5%. Bei einer durchschnittlichen Lebenserwartung von mehr als vier Jahren ist auch in dieser Altersgruppe der Einsatz einer kurativen Strahlentherapie sinnvoll. Ausserdem deuten verschiedene retrospektive Studien darauf hin, dass die Raten an lokaler Tumorkontrolle und krankheitsspezifischem Ueberleben nach Strahlentherapie mit denen juengerer Patienten vergleichbar sind. Eine Ausnahme bilden unter anderem aeltere Patienten mit Gliomen Grad III bis IV und mit Rektumkarzinom, die ein schlechteres Ueberleben aufweisen. Dieses ist eventuell auf eine weniger aggressive Kombinationstherapie (Tumorresektion) zurueckzufuehren. Obwohl strahlen- und molekularbiologische Daten auf einen Anstieg der Strahlenempfindlichkeit mit zunehmendem Alter hinweisen, wie zum Beispiel das Nachlassen der Kapazitaet

Synthesis and structural characterisation of mixed An(IV)-An(III) actinide oxalates used as precursors for dedicated fuel or target

International Nuclear Information System (INIS)

Tamain, Christelle; Grandjean, Stephane; Arab Chapelet, Benedicte; Abraham, Francis

2010-01-01

Oxalic co-conversion process plays an important role by producing mixed-actinide compounds used as starting materials as they are particularly suitable precursors of actinide oxide solid solutions. In these oxalate compounds, a mixed crystallographic site which accommodates both elements in spite of their different oxidation states has been established. The charge compensation is ensured by monovalent cations present in the acidic solution. This communication reviews the various mixed-actinide oxalates obtained by crystallization from acidic solution. First, crystallographic structures determined by X-ray diffraction from single crystals are described. Then completing data obtained by powder X-ray diffraction are presented on various systems. The different supramolecular arrangements underline the complexity of An(IV)-An(III)/Ln(III) oxalate system and the need to pursue studies on single crystals. (authors)

Klima- und umweltbezogene Lernprozesse in partizipativen Produktentwicklungsverfahren: Möglichkeiten und Grenzen

Directory of Open Access Journals (Sweden)

Marlen Arnold

2009-08-01

Full Text Available Für erfolgreiche und nachhaltige Produktentwicklung reichen heute Marktbeobachtung und Kund/innenbefragungen alleine nicht mehr aus. Mit Verfahren zur partizipativen Produktentwicklung (PPE können sowohl das kreative Potenzial von Nutzer/innen für die Produktentwicklung erschlossen als auch marktfähige nachhaltige Produkte entwickelt werden. Sie ermöglichen so aktives Nachhaltigkeitsmanagement. Am Beispiel des INNOCOPE-Pilotverfahrens wird diskutiert, wie nachhaltigkeitsbezogene Lernprozesse in PPE-Prozessen initiiert werden können und welche Faktoren dabei wesentlich sind. Insgesamt zeigt sich, dass vor allem die sich wiederholende, direkte und möglichst gleichberechtigte Interaktion von Unternehmensvertreter/innen und von Konsument/innen einen themenbezogenen Wissensaustausch und wechselseitige Lernprozesse ermöglicht. Dabei sind der inhaltliche Aufbau der Treffen und der zeitlich gestaffelte Einsatz von Lernmethoden wesentlich.Today, market observation and customer surveys alone do not suffice to develop successful and sustainable products. Methods of participatory product development (PPD allow to open up the creative potential of users for product development, and to develop marketable sustainable products. Thereby, they support active sustainability management. Taking the INNOCOPE pilot process as an example, we discuss the possibilities and the relevant factors to initiate sustainability- and climate-related learning processes within PPD processes. Our findings indicate that repeated, direct and equitable interaction between company representatives and customers are fundamental for relevant knowledge exchange and mutual learning processes. Other key issues are the thematic structure of the meetings and the timing of learning methods.

Klimaanpassung in Land- und Forstwirtschaft: Ergebnisse eines Workshops der Ressortforschungsinstitute FLI, JKI und Thünen-Institut

OpenAIRE

Schimmelpfennig, Sonja; Heidecke, Claudia; Beer, Holger; Bittner, Florian; Klages, Susanne; Krengel, Sandra; Lange, Stefan

2018-01-01

Das Working Paper stellt die Ergebnisse einer Umfrage und eines Workshops zusammen, die von Wissenschaftlern und Wissenschaftlerinnen der Ressortforschungsinstitute Thünen-Institut, Julius Kühn-Institut (JKI) und Friedrich-Loeffler-Institut (FLI) im Herbst 2016 zusammengetragen und diskutiert worden sind. Ziel des Workshops und der Umfrage war, den Stand des Wissens zu Klimaanpassungsthemen in der Ressortforschung des BMEL und die zukünftigen Herausforderungen einer Anpassung an den Klimawand...

Imagineering the astronomical revolution - Essay review

Science.gov (United States)

Jardine, Nicholas.

2006-11-01

Concerning following Books: (I) Transmitting knowledge - words, images, and instruments in early modern Europe. Kusukawa and Maclean (eds.), OUP, Oxford, 2006; (II) Widmung, Welterklärung und Wissenschaftslegitimierung: Titelbilder und ihre Funktionen in der wissenschaftlichen Revolution. Remmert, Harrassowitz, Wiesbaden, 2005; (III) The power of images in early modern science. Lefevre, Renn and Schoepflin (eds.), Birkhäuser, Basel, 2003; (IV) Immagini per conoscere - dal Rinascimento alla rivoluzione scientifica. Meroi and Pogliano (eds.), Olschki, Florenz, 2001; (V) Erkenntnis Erfindung Konstruktion - Studien zur Bildgeschichte von Naturwissenschaften und Technik vom 16. bis zum 19. Jahrhundert. Holländer (ed.), Mann, Berlin, 2000.

Diagnostik und Therapie der kutanen Androgenisierung im klimakterischen Übergang sowie in der Peri- und Postmenopause: Hirsutismus und Alopezie

Directory of Open Access Journals (Sweden)

Geisthövel F

2012-01-01

Full Text Available Die weibliche Androgenisierung umfasst ein weites Spektrum an heterogenen Dysfunktionen und Erkrankungen. Um die Therapieprinzipien des Hirsutismus sowie der Alopecia androgenetica während des klimakterischen Übergangs („menopausal transition“ [MT] und der Peri-/Postmenopause zu erfassen, ist es sinnvoll, sich auf eine Gruppe von androgenisierten Patientinnen zu beschränken, bei der die Haut pathogenetisch im Fokus liegt. Solch eine klar definierte Patientengruppe, die „funktionell kutane Androgenisierung“ (FCA, kann meist schon über die Diagnostikebene 1 (Screening-Ebene unseres Klassifikations-Algorithmus diagnostiziert werden. Der Ferriman-Gallwey-Index bzw. eine modifizierte Sinclair-Scale dienen zur Gradeinteilung von Hirsutismus bzw. Alopezie. Die ausgeprägte endokrine Dynamik während der MT ist hormondiagnostisch zu beachten. Wachsepilation und Lasertherapie sind vielfältig eingesetzte topischmechanische bzw. -physikalische Therapieverfahren. Eine topische Behandlung des Hirsutismus kann auch mit Eflornithin-Creme durchgeführt werden, die den Effekt einer Lasertherapie unterstützt. Minoxidil-Lösung gilt als Mittel der ersten Wahl bei der topischen Therapie der Alopecia androgenetica. Steroidale Präparate, welche aus der kontrazeptiven Kombination von Ethinylestradiol und antiandrogenen Gestagenen (AA bestehen, sind therapeutische Prinzipien bei androgenisierten Patientinnen in der MT, sie sind hingegen in der Postmenopause kontraindiziert. Die orale Einnahme von Spironolacton und/oder Finasterid, beides nicht-steroidale Antiandrogene, ist während der MT unter sicherer Kontrazeption und jene von Spironolacton für die Alopezie in der Postmenopause gut geeignet. Die Einnahme von Kombinationsprapäraten, welche die nicht-kontrazeptiven natürlichen Östrogene und AA enthalten, sind für die Behandlung der FCA bei Patientinnen indiziert, die zusätzlich unter klimakterischen und peri-/postmenopausalen Störungen leiden

Logos und etos der Heiligkeit im Licht der liturgischen Texte vom hl. Stanislaus, Bischof und Märtyrer

Directory of Open Access Journals (Sweden)

Jan Józef Janicki

2003-12-01

Full Text Available Im Jahr 2003 feiert die Kirche in Polen das 750-jährige Jubiläum der Heiligsprechung des Bischofs Stanislaus (1030-1079, der im Jahre 1253 in Assisi, als erste Pole, kanonisiert wurde und zum Patron von ganz Polen ernannt. Der Verfasser analisiert das Messformular und Stundengebetsformular von der liturgischen Feier des hl. Stanislaus, Bischof und Märtyrer am 8 Mai und sucht dadurch die Lehre (logos über das christliche Leben und die konkrete Lebens-Konsequenzen (etos aufzuzeigen. Die erneuerten liturgischen Texte der Gebete des neuen römischen Messbuches und des Stundengebetes zeigen den Glauben der betenden Kirche nach dem alten Prinzip: legem credendi lex statuat supplicandi (oder kurz ausgedrückt: lex orandi lex credendi. Der Zweck also des hier vorgestellten Artikels ist es, den Glauben der Kirche über das heilige Leben der Christen zu demonstrieren, welches uns eine Analyse der euchologischen Texte und der Texte der Wortliturgie ermöglicht. Der Verfasser benutzte dann die Möglichkeit, diese ganze Problematik im breiten theologisch-liturgischen und pastoralen Kontext darzustellen. Dabei benutzte er die Dokumente der Kirche der letzten Jahre, insbesondere die Lehre des II. Vatikanischen Konzils wenn es um den pastoralen Dienst der Bischöfe geht, dann die pastoral-theologischen Briefe des Papstes Pius XII und des Papstes Johannes Paul II, zum 700-jährigen und zum 750-jährigen Jubiläum der Kanonisation des hl. Bischofs Stanislaus. Es geht aber auch um alles das, was Johannes Paul II und früher als Kardinal Karol Wojtyła zum Jahrestag des Märtyrertodes geschrieben hat. Die liturgischen Gebetstexte lex orandi und die Wortliturgie unterstreichen in ihrer lex credendi, dass der hl. Stanislaus in seinem Leben, in seiner Zeit und seiner Kirche, den Auftrag und die Vollmacht - die Christus den Aposteln und ihren Nachfolgern gegeben hat - alle Völker zu lehren, die Menschen in der Wahrheit zu heiligen und sie zu weiden, verwirklicht

Editorial zum Tagungsband: Spannungsfelder und blinde Flecken. Medienpädagogik zwischen Emanzipationsanspruch und Diskursvermeidung

Directory of Open Access Journals (Sweden)

Sven Kommer

2017-10-01

Full Text Available Die erziehungswissenschaftliche Auseinandersetzung mit Medien hat in Deutschland eine lange und vielfältige Tradition. In den letzten Jahrzehnten hat sich die Medienpädagogik zu einer eigenständigen akademischen (Teil-Disziplin entwickelt, die in der (Fach-Öffentlichkeit wahrgenommen wird und sich aktiv in aktuelle gesellschaftliche Diskurse einbringt. Sichtbar wird die Etablierung als Fach u. a. daran, dass an einer Reihe von Hochschulen Professuren geschaffen wurden, die für medienpädagogische Studienelemente oder -gänge und/oder Zusatzausbildungen verantwortlich sind. Der gestiegene Stellenwert der Disziplin zeigt sich auch an ihrer Rolle in der Deutschen Gesellschaft für Erziehungswissenschaft, innerhalb derer sie sich von einer «Arbeitsgemeinschaft auf Zeit» (Mitte der 1990er-Jahre zu einer eigenständigen Sektion (seit 2010 entwickelt hat. Angesichts der gegenwärtig zu beobachtenden Entwicklungen im Medienbereich (u. a. Digitalisierung, Globalisierung, Algorithmisierung, deren Folgen für gesellschaftliche und pädagogische Prozesse und Bereiche kaum zu unterschätzen sind, erstaunt es, dass die Medienpädagogik bis heute dazu neigt, Rechtfertigungsstrategien für die eigenen Existenz zu generieren. Bei einer kritischen Betrachtung (z. B. der universitären Stellenpolitik ist aber zu konstatieren, dass sich die Medienpädagogik auch 40 Jahre nach dem Erscheinen von Dieter Baackes wegweisender Schrift Kommunikation und Kompetenz ihrer Anerkennung und festen Verankerung im akademischen Feld tatsächlich noch immer nicht sicher sein kann. Eine Ursache hierfür liegt möglicherweise in der noch immer grossen (und oftmals geradezu zelebrierten Heterogenität des Faches. So sind die unterschiedlichen Traditionslinien des pädagogischen Umgangs mit Medien, die mitunter nur bedingt miteinander vereinbar sind, bis heute zu beobachten und wirkmächtig. Zu unterscheiden ist hierbei bspw. eine auf Emanzipation, kommunikative Kompetenz

Digitalisierung und Selbstbestimmung

Directory of Open Access Journals (Sweden)

Bezemek, Christoph

2017-12-01

Full Text Available Der vorliegende Beitrag skizziert das Zusammenspiel von Digitalisierung und individueller Selbstbestimmung, stellt die Frage, welche Herausforderungen dieses Zusammenspiel birgt und diskutiert, wie ihnen begegnet werden kann.

Editorial 01/2013 Normen und Normierungen

Directory of Open Access Journals (Sweden)

Christian Swertz

2013-03-01

Full Text Available Auf unterschiedlichsten Ebenen werden die Diskussionen und Forschungen der Medienpädagogik von normativ aufgeladenen Begriffen durchzogen: so, wenn es um Standards in der Medienbildung geht, wenn beispielsweise diskutiert wird, welche Inhalte in welcher Form vermittelt werden sollen; so auch wenn zur Debatte steht, wie Medienpädagogik institutionalisiert werden sollte und welche Voraussetzungen gegeben sein müssen, um einen geplanten Bildungsprozess zu lenken oder anzuleiten.Derartige Norm(ierungen wurden bereits mit der Konzeptualisierung des Begriffs Medienkompetenz und im Blick auf die Emanzipation des Menschen kritisch beleuchtet, womit auch Kritik an gesellschaftlichen Herrschafts- und Machtstrukturen verbunden war. Die Orientierung an der sozialwissenschaftlich verstandenen Emanzipation des Menschen ist allerdings in anderen pädagogischen Disziplinen durchaus umstritten. Gleichzeitig ist zu beobachten, dass die gesellschaftskritische Perspektive im medienpädagogischen Diskurs über die Orientierung von Medienkompetenz und Medienbildung eine immer geringere Rolle spielt. Deshalb hat sich die Redaktion der MEDIENIMPULSE entschlossen, dem Thema Normen und Normierungen eine eigene Ausgabe zu widmen.Dabei sollten folgende Fragen behandelt werden:Wie sieht es mit Norm(ierungen im Bereich der Mediendidaktik aus? Wie sind die mit aktuellen Medienkompetenz- und Medienbildungsbegriffen verbundenen Normen epistemologisch und (medientheoretisch abgestützt? Wie lassen sich – nur scheinbar paradox formuliert – wissenschaftlich begründbare medienpädagogische Normen finden, die sich den genannten Normierungen widersetzen und entziehen? Inwiefern führt die Einführung von Laptopklassen oder Smartboards im schulischen Bereich oder die Gestaltung von Videospielprojekten in der außerschulischen Medienbildung zu einer unreflektierten Sozialdisziplinierung, die als illegitime Form(atierung des Menschen verstanden werden kann? Der Schwerpunktteil

Fluchen und Flamen, um ein Mann zu sein? Die Verknüpfung von Geschlecht und Sprache durch Vorurteile

Directory of Open Access Journals (Sweden)

Nicola Döring

2001-11-01

Full Text Available Die hier besprochene Monographie der Linguistin Anja Gottburgsen beschäftigt sich theoretisch und empirisch mit sprachbezogenen Geschlechterstereotypen, also mit unseren Vorstellungen darüber, ob und wie Männer und Frauen jeweils in spezifischer und distinkter Weise sprachlich kommunizieren. Im Theorieteil der Arbeit wird der aktuelle Stand der soziolinguistischen und sozialpsychologischen Diskussion zu Geschlecht, Sprachverhalten und Stereotypisierung kritisch referiert und die Bedeutung von sprachbezogenen Geschlechterstereotypen erläutert. Im empirischen Teil berichtet die Autorin die Ergebnisse von drei Fragebogen-Studien mit deutschsprachigen Studierenden. Es zeigt sich, dass bei Studierenden unabhängig von Geschlecht und Geschlechtsrollenorientierung stereotype Vorstellungen über das sprachliche Verhalten von Männern und Frauen verbreitet sind.

Analysis of novel silicon and III-V solar cells by simulation and experiment; Analyse neuartiger Silizium- und III-V-Solarzellen mittels Simulation und Experiment

Energy Technology Data Exchange (ETDEWEB)

Hermle, Martin

2008-11-27

This work presents various simulation studies of silicon and III-V solar cells. For standard silicon solar cells, one of the critical parameters to obtain good performance, is the rear side recombination velocity. The optical and electrical differences of the different cell structures were determined. The optical differences and the effective recombination velocity Sback of the different rear side structures for 1 Ohmcm material were extracted. Beside standard silicon solar cells, back junction silicon solar cells were investigated. Especially the influence of the front surface field and the electrical shading due to the rear side, was investigated. In the last two chapters, III-V solar cells were analysed. For the simulation of III-V multi-junction solar cells, the simulation of the tunneldiode is the basic prerequisite. In this work, the numerical calibration of an GaAs tunneldiode was achieved by using an non-local tunnel model. Using this model, it was possible to successfully simulate a III-V tandem solar cell. The last chapter deals with an optimization of the III-V 3-junction cell for space applications. Especially the influence of the GaAs middle cell was investigated. Due to structural changes, the end-of-life efficiency was drastically increased.

Some studies on the reaction between nitrous acid and plutonium(IV)

International Nuclear Information System (INIS)

Vasudeva Rao, P.R.; Bagawde, S.V.; Ramakrishna, V.V.; Patil, S.K.

1976-01-01

In the ion exchange and solvent extraction studies nitrous acid is used as an oxidant for Pu(IV) in perchloric acid. Earlier studies had indicated that Pu(IV) forms complex with nitrous acid. The present investigation aimed to study this complex formation by solvent extraction and spectrophotometric methods, revealed that is no significant complex formation between Pu(IV) and nitrous acid. The high apparent equilibrium constant for the complex formation is caused by the partial reduction of Pu(IV) to Pu(III) by nitrous acid. The nitrate complexing is negligible in the case of Th(IV) and Np(IV) as well. Systematic investigation on the redox reactions of plutonium in different oxidation states with nitrous acid is now in progress. The preliminary results obtained indicate that Pu(IV) is reduced to Pu(III) by nitrous acid with a rate that can be conveniently followed spectrophotometrically. (T.I.)

Editorial: Informationstechnische Bildung und Medienerziehung

Directory of Open Access Journals (Sweden)

Annemarie Hauf-Tulodziecki

2001-10-01

Full Text Available Die schulische Medienerziehung bzw. die Medienbildung hat ihre derzeit hohe öffentliche Aufmerksamkeit nicht zuletzt der Tatsache zu verdanken, dass gerade die so genannten «Neuen Medien» - heute oft mit den Schlagworten «Multimedia» oder «Internet» abgekürzt - wichtige Erziehungs- und Bildungsmassnahmen erforderlich machen. In der öffentlichen Diskussion gehören inhaltliche Kurzschlüsse zur Tagesordnung: Wenn von «Medienkompetenz» die Rede ist, verbirgt sich dahinter häufig nur ein «Internetführerschein». Diese Beobachtung ärgert nicht nur Medienpädagogen, sondern auch Vertreter einer Informationstechnischen Bildung (1, da berechtigte pädagogische Ansprüche beider Gruppen wenig Beachtung finden. Mittlerweile gibt es eine Reihe von Empfehlungen von BLK und KMK zu diesem Thema, in denen zudem deutlich auf die wechselseitigen Bezüge hingewiesen werden. Die wachsende Bedeutung des Mediums Computer und die weiter zunehmende Digitalisierung traditioneller Medien erfordert sowohl für die Medienerziehung als auch für die Informatische Bildung eine Weiterentwicklung ihrer Ziele und Inhalte. Die Gesellschaft für Informatik e.V. hat 1999 in ihrer Empfehlung «Informatische Bildung und Medienerziehung» aus ihrer Perspektive dargestellt, welche Aufgaben auf die Medienerziehung zukommen, wenn auch die Informations- und Kommunikationstechnologien bzw. die computerbasierten Medien in einer angemessenen Form thematisiert werden sollen. Erste praktische Ansätze, Inhalte aus beiden Bereichen bewusst zusammenzuführen, auch unter einer gemeinsamen Fach- oder Kursbezeichnung, sind häufig additiv und orientieren sich – trotz vorhandener Überschneidungen – an den etablierten medienpädagogischen oder an den informatischen Unterrichtsprinzipien. In dem vorliegenden Themenheft wird aus einer übergeordneten, medienpädagogischen Perspektive die Frage gestellt, wie eine konsistente Weiterentwicklung der Medienerziehung unter angemessener

New lethal disease involving type I and III collagen defect resembling geroderma osteodysplastica, De Barsy syndrome, and Ehlers-Danlos syndrome IV.

OpenAIRE

Jukkola, A; Kauppila, S; Risteli, L; Vuopala, K; Risteli, J; Leisti, J; Pajunen, L

1998-01-01

We describe the clinical findings and biochemical features of a male child suffering from a so far undescribed lethal connective tissue disorder characterised by extreme hypermobility of the joints, lax skin, cataracts, severe growth retardation, and insufficient production of type I and type III procollagens. His features are compared with Ehlers-Danlos type IV, De Barsy syndrome, and geroderma osteodysplastica, as these disorders show some symptoms and signs shared with our patient. The chi...

Global Governance und libertärer Paternalismus: Akteure, Normativität und Legitimität

Directory of Open Access Journals (Sweden)

Mende Janne

2016-07-01

Full Text Available Der libertäre Paternalismus weist ähnliche Bezugspunkte auf wie die Global Governance. Bei beiden handelt es sich um ein Bündel staatlicher und nichtstaatlicher Steuerungsversuche, die auf eine Lösung individueller und gesellschaftlicher Probleme abzielen. Eine Verschränkung der Perspektiven beider Konzepte verhilft zu einer genaueren Konturierung ihrer konzeptuellen und normativen Prämissen und zu einer Diskussion ihrer Engführungen und Stärken. Deutlich wird: Der normative Bezugsrahmen des ‚besseren Lebens‘ für die Einzelne (Nudging oder für die Gesellschaft (Global Governance benötigt jeweils genauere Bestimmungen des Verhältnisses von Freiheit und Struktur. Die Regulierungsfähigkeit staatlicher und nichtstaatlicher Akteure wird durch jeweils offenzulegende Legitimitätsannahmen bestimmt. Aus der Perspektivenverschränkung ergeben sich Fragen nach der Strukturierung von Entscheidungsräumen in Global Governance (Nudging Governance und nach den Kriterien für eine Regulierung des libertären Paternalismus (Governing Nudges. Eine Diskussion dieser Fragen ist unabdingbar für eine reflexive Fundierung der Kritik oder der Weiterentwicklung der Konzepte.

Das Sabbatjahr für Lehrerinnen und Lehrer: Wer profitiert und in welcher Form?

OpenAIRE

Rothland, Martin

2013-01-01

Das Sabbatjahr für Lehrerinnen und Lehrer wird programmatisch als Maßnahme der Belastungsreduktion, der Regeneration sowie der Ressourcenstärkung diskutiert. Empirische Belege für die erwarteten Effekte finden sich jedoch kaum. Im Rahmen einer Längsschnittstudie mit drei Erhebungszeitpunkten vor, während und nach dem Sabbatjahr werden die Entwicklung der Belastungswahrnehmung, des Gesundheitszustands und allgemeiner sowie arbeitsbezogener Emotionen (Berufs- und Lebenszufriedenheit) auf der Ba...

Forschende und ihre Daten: Ergebnisse einer österreichweiten Befragung. Report 2015 – Executive Summary und Empfehlungen

Directory of Open Access Journals (Sweden)

Bruno Bauer

2015-01-01

Full Text Available Der vorliegende Beitrag bringt Executive Summary und Empfehlungen aus „Forschende und ihre Daten: Ergebnisse einer österreichweiten Befragung. Report 2015“. Dieser Report gibt einen Überblick über die österreichweite Befragung zu Forschungsdaten, die im Rahmen des Projekts e-Infrastructures Austria 2015 durchgeführt wurde. Diese richtete sich an das wissenschaftliche und künstlerisch-wissenschaftliche Personal aller 21 öffentlichen Universitäten sowie an drei außeruniversitäre Forschungseinrichtungen in Österreich. Die Teilnehmenden wurden zu folgenden Themenbereichen befragt: Datentypen und Formate; Datenarchivierung, -sicherung und -verlust; ethische und rechtliche Aspekte; Zugänglichkeit und Nachnutzung; Infrastruktur und Services. Die in diesem Kontext erstmals auf nationaler Ebene durchgeführte Befragung diente der Erhebung des praktischen Umgangs mit Forschungsdaten in Österreich und ist somit die Basis für eine konsekutive Optimierung der zweckdienlichen Infrastruktur, für eine Anpassung der Serviceangebote sowie für eine Neuorientierung bei der Ermittlung von Ressourcen in diesem strategischen Bereich entsprechend der geäußerten Bedürfnisse der im Forschungsprozess Tätigen.

Bewältigungsstrategien der Oberwalliser Primarlehrpersonen und Massnahmen der Gesundheitsförderung an Oberwalliser Primarschulen bei Stress und Burnout

OpenAIRE

Imhof, Barbara; Mattig, Astrid

2009-01-01

Die vorliegende Studie befasst sich mit der Gesundheitsförderung bei Stress und Burnout an den Oberwalliser Primarschulen und der Bewältigungsstrategien der Oberwalliser Primarlehrpersonen bei Stress und Burnout. Der theoretische Teil befasst sich mit Stress und Burnout und der Bewältigung von Stress und Burnout. Verschiedene Aspekte des Lehrerberufs werden näher angeschaut und es werden mögliche Massnahmen der Gesundheitsförderung bei Stress und Burnout aufgeführt. Die Untersuchung zeigt, da...

Transoral Robotic Surgery in Treating Patients With Benign or Stage I-IV Head and Neck Cancer

Science.gov (United States)

2014-11-07

III Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage III Squamous Cell Carcinoma of the Nasopharynx; Stage III Squamous Cell Carcinoma of the Oropharynx; Stage III Verrucous Carcinoma of the Larynx; Stage III Verrucous Carcinoma of the Oral Cavity; Stage IV Adenoid Cystic Carcinoma of the Oral Cavity; Stage IV Lymphoepithelioma of the Nasopharynx; Stage IV Lymphoepithelioma of the Oropharynx; Stage IV Mucoepidermoid Carcinoma of the Oral Cavity; Stage IV Squamous Cell Carcinoma of the Hypopharynx; Stage IV Squamous Cell Carcinoma of the Larynx; Stage IV Squamous Cell Carcinoma of the Lip and Oral Cavity; Stage IV Squamous Cell Carcinoma of the Nasopharynx; Stage IV Squamous Cell Carcinoma of the Oropharynx; Stage IV Verrucous Carcinoma of the Larynx; Stage IV Verrucous Carcinoma of the Oral Cavity

Trauma und Terror

OpenAIRE

Szyszkowitz, T. (Tessa)

2007-01-01

1. Einleitung Ausgehend von der Fragestellung, warum gerade bei Tschetschenen und Palästinensern der Selbstmordterrorismus in den letzten Jahren so populär geworden ist, analysiert die Autorin die Geschichte dieser beiden Völker. Einer der Gründe ist bisher wenig beachtet worden. Der Einfluss eines kollektiven Traumas, das als solches nicht anerkannt, behandelt und auch nicht einer politischen Lösung zugeführt wurde. 2. Geschichte der Palästinenser und Tschetschenen Im Zuge der Err...

[St. Petersburg und Livland - und die Entwicklung der estnischen Literatur : Anton Schiefner (1817-1879) und Friedrich R. Kreutzwald (1803-1882) im Briefwechsel (1853-1879)] / Felix Köther

Index Scriptorium Estoniae

Köther, Felix

2015-01-01

Arvustus: St. Petersburg und Livland - und die Entwicklung der estnischen Literatur : Anton Schiefner (1817-1879) und Friedrich R. Kreutzwald (1803-1882) im Briefwechsel (1853-1879) / bearbeitet von Hartmut Walravens. Wiesbaden : Harrassowitz, 2013. (Orientalistik-Bibliographien und Dokumentationen ; Bd. 22)

Work-Life-Balance und Frauenbiographien

OpenAIRE

Macha, Hildegard

2006-01-01

Work-Life-Balance und Frauenbiographien. - In: Bildungs- und Karrierewege von Frauen / Anne Schlüter (Hrsg.). - Opladen : Budrich, 2006. - S. 17-32. - (Reihe: Frauen- und Geschlechterforschung in der Erziehungswissenschaft ; 2)

Herausforderungen kleiner und mittlerer Unternehmen

Science.gov (United States)

Bergmann, Lars; Crespo, Isabel

Vielfältige externe Herausforderungen, hervorgerufen durch die Dynamik, mit der sich die wirtschaftliche, technologische, soziokulturelle sowie politische Umwelt wandelt, muss jedes Unternehmen im Laufe der Zeit bestehen (Zäpfel 2000). Diese Herausforderungen werden heute insbesondere durch eine Globalisierung der Wettbewerbssowie Nachfragestrukturen verstärkt. Immer schnellere Prozessund Produktinnovationen, kürzere Produktlebenszyklen und Entwicklungszeiten, eine rasant steigende Variantenvielfalt, Nachfrageschwankungen sowie rasante Entwicklungen der Informations- und Kommunikationstechnologien sind einige der sich schnell verändernden Rahmenbedingungen. Zudem müssen sich Unternehmen an neue Gesetze und rechtliche Rahmenbedingungen anpassen. Im Bereich der Roh- und Einsatzstoffe sind Veränderungen insbesondere durch sich verknappende Rohstoffe und Primärenergieträger und in Folge dessen durch drastische Preissteigerungen für Materialien, Hilfsstoffe, Werkzeuge etc. geprägt.

[Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen. Stadt, Land und Konfession 1500-1721. Teil I] / Heinrich Wittram

Index Scriptorium Estoniae

Wittram, Heinrich, 1931-

2011-01-01

Arvustus : Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen. Stadt, Land und Konfession 1500-1721. Teil I. Münster : Aschendorff, 2009. (Katholisches Leben und Kirchenreform im Zeitalter der Glaubensspaltung, 69)

Shewanella putrefaciens mtrB encodes an outer membrane protein required for Fe(III) and Mn(IV) reduction.

Science.gov (United States)

Beliaev, A S; Saffarini, D A

1998-12-01

Iron and manganese oxides or oxyhydroxides are abundant transition metals, and in aquatic environments they serve as terminal electron acceptors for a large number of bacterial species. The molecular mechanisms of anaerobic metal reduction, however, are not understood. Shewanella putrefaciens is a facultative anaerobe that uses Fe(III) and Mn(IV) as terminal electron acceptors during anaerobic respiration. Transposon mutagenesis was used to generate mutants of S. putrefaciens, and one such mutant, SR-21, was analyzed in detail. Growth and enzyme assays indicated that the mutation in SR-21 resulted in loss of Fe(III) and Mn(IV) reduction but did not affect its ability to reduce other electron acceptors used by the wild type. This deficiency was due to Tn5 inactivation of an open reading frame (ORF) designated mtrB. mtrB encodes a protein of 679 amino acids and contains a signal sequence characteristic of secreted proteins. Analysis of membrane fractions of the mutant, SR-21, and wild-type cells indicated that MtrB is located on the outer membrane of S. putrefaciens. A 5.2-kb DNA fragment that contains mtrB was isolated and completely sequenced. A second ORF, designated mtrA, was found directly upstream of mtrB. The two ORFs appear to be arranged in an operon. mtrA encodes a putative 10-heme c-type cytochrome of 333 amino acids. The N-terminal sequence of MtrA contains a potential signal sequence for secretion across the cell membrane. The amino acid sequence of MtrA exhibited 34% identity to NrfB from Escherichia coli, which is involved in formate-dependent nitrite reduction. To our knowledge, this is the first report of genes encoding proteins involved in metal reduction.

GIS und Fernerkundung für Landschaftsmonitoring und Landschaftsplanung

Science.gov (United States)

Blaschke, Thomas

2002-09-01

Der Beitrag beleuchtet die Rolle der Geographischen Informationsverarbeitung hinsichtlich der Aufgaben in der Umweltüberwachung. Dabei wird über etablierte "sektorale" Umweltbeobachtungssysteme (Boden, Wasser, Luft) hinaus zunehmend der Bedarf an einer integrativen Betrachtung der Landschaft deutlich, insbesondere in mittleren bis kleinen Maßstäben. Wie verändern sich ganze Landschaften in Deutschland, in Europa? Welches sind Bereiche kritischer Abnahme landschaftlicher Diversität? Wie können landschaftliche Vielfalt und Eigenart erhalten beziehungsweise deren Erhalt überwacht werden? Diese und weitere Fragen drängen sich vor allem bei der Erstellung langfristiger Szenarien der Veränderung ganzer Landschaften und in der Nachhaltigkeitsdiskussion auf.

DAPPA grafted polymer: an efficient solid phase extractant for U(VI), Th(IV) and La(III) from acidic waste streams and environmental samples.

Science.gov (United States)

Raju, Ch Siva Kesava; Subramanian, M S

2005-07-15

A new class of polymeric resin has been synthesized by grafting Merrifield chloromethylated resin with (dimethyl amino-phosphono-methyl)-phosphonic acid (MCM-DAPPA), for the preconcentration of U(VI), Th(IV) and La(III) from both acidic wastes and environmental samples. The various chemical modification steps involved during grafting process are characterized by FT-IR spectroscopy, (31)P and (13)C-CPMAS (cross-polarized magic angle spin) NMR spectroscopy and CHNS/O elemental analysis. The water regain capacity data for the grafted polymer are obtained from thermo-gravimetric (TG) analysis. The influence of various physico-chemical parameters during the quantitative extraction of metal ions by the resin phase are studied and optimized by both static and dynamic methods. The significant feature of this grafted polymer is its ability to extract both actinides and lanthanides from high-level acidities as well as from near neutral conditions. The resin shows very high sorption capacity values of 2.02, 0.89 and 0.54mmolg(-1) for U(VI), 1.98, 0.63 and 0.42mmolg(-1) for Th(IV) and 1.22, 0.39 and 0.39mmolg(-1) for La(III) under optimum pH, HNO(3) and HCl concentration, respectively. The grafted polymer shows faster phase exchange kinetics (99.5% recovery using 1M (NH(4))(2)CO(3), as eluent. The developed grafted resin has been successfully applied in extracting Th(IV) from high matrix monazite sand, U(VI) from sea water and also U(VI) and Th(IV) from simulated nuclear spent fuel mixtures. The analytical data obtained from triplicate measurements are within 3.9% R.S.D. reflecting the reproducibility and reliability of the developed method.

Expression, crystallization and preliminary X-ray analysis of the extracellular Ig modules I–IV and F3 modules I–III of the neural cell-adhesion molecule L1

International Nuclear Information System (INIS)

Kulahin, Nikolaj; Kasper, Christina; Kristensen, Ole; Kastrup, Jette Sandholm; Berezin, Vladimir; Bock, Elisabeth; Gajhede, Michael

2005-01-01

Mouse L1 modules Ig I–IV and F3 I–III were crystallized. The crystals diffracted X-rays to 3.5 and 2.8 Å resolution, respectively. Four amino-terminal immunoglobulin (Ig) modules and three fibronectin type III (F3) modules of the mouse neural cell-adhesion molecule L1 have been expressed in Drosophila S2 cells. The Ig modules I–IV of L1 crystallized in a trigonal space group, with unit-cell parameters a = b = 239.6, c = 99.3 Å, and the crystals diffracted X-rays to a resolution of about 3.5 Å. The F3 modules I–III of L1 crystallized in a tetragonal space group, with unit-cell parameters a = b = 80.1, c = 131 Å, and the crystals diffracted X-rays to 2.8 Å resolution. This is a step towards the structure determination of the multimodular constructs of the neural cell-adhesion molecule L1 in order to understand the function of L1 on a structural basis

Zu den Grundlagen der visuellen Soziologie: Wahrnehmen und Sehen, Beobachten und Betrachten

OpenAIRE

Bachleitner, Reinhard; Weichbold, Martin

2015-01-01

In diesem Beitrag werden die visuellen Modi des Wahrnehmens – das Sehen, Beobachten und Betrachten – in ihrem Wesen skizziert, und die doppelte Theorieabhängigkeit von Wahrnehmungsprozessen wird thematisiert. Dabei zeigt sich, dass mehrere offene methodologische und erkenntnistheoretische Fragen durch die Differenzierung des Wahrnehmungsvorgangs in drei Stufen (reines Sehen, kognitive Repräsentation, Transformation des Perzepts in Worte) sowie die Differenzierung der Wahrnehmungsmodi in jewei...

A Stable Coordination Complex of Rh(IV) in an N,O-Donor Environment

Energy Technology Data Exchange (ETDEWEB)

Sinha, Shashi B. [Department of Chemistry, Yale University, 225 Prospect; Shopov, Dimitar Y. [Department of Chemistry, Yale University, 225 Prospect; Sharninghausen, Liam S. [Department of Chemistry, Yale University, 225 Prospect; Vinyard, David J. [Department of Chemistry, Yale University, 225 Prospect; Mercado, Brandon Q. [Department of Chemistry, Yale University, 225 Prospect; Brudvig, Gary W. [Department of Chemistry, Yale University, 225 Prospect; Crabtree, Robert H. [Department of Chemistry, Yale University, 225 Prospect

2015-12-10

We describe facial and meridional isomers of [RhIII(pyalk)3], as well as meridional [RhIV(pyalk)3]+ {pyalk =2-(2-pyridyl)-2-propanoate}, the first coordination complex in an N,O-donor environment to show a clean, reversible RhIII/IV redox couple and to have a stable Rh(IV) form, which we characterize by EPR and UV–visible spectroscopy as well as X-ray crystallography. The unprecedented stability of the Rh(IV) species is ascribed to the exceptional donor strength of the ligands, their oxidation resistance, and the meridional coordination geometry.

Mandelazo I as a reagent for Zr(IV) determination

International Nuclear Information System (INIS)

Rakha, T.H.; Filip, P.; Stefan, N.

1984-01-01

A spectrometric study of the reaction of the Zr(IV) ions with Mandelazo I was carried out. Absorption spectra revealed that the maximum absorption of the zirconium compound appears at a wavelength (316 nm) different from the maxima of the reagent (253 and 390 nm). Beer-Lambert law is followed for zirconium concentrations of the order of 8.8 x 10 -5 M (i.e. 8 μg Zr(IV)/mL). Possible interferences of ions such as Be(II), Cu(II), Zn(II), Al(III), Th(IV), U(VI), Mn(II), Fe(III), Co(II) and Ni(II) were investigated in connection with some masking agents such as SO 4 2- and C 2 O 4 2- . Also, the solid state Zr(IV)- Mandelazo I compound was prepared and characterized by nitrogen and thermogravimetric analyses

Separation method for ions of elements of the III., IV., VI. and VIII. groups of periodical system

International Nuclear Information System (INIS)

Marhol, M.

1973-01-01

The method is presented of separating the ions of the elements of the periodic system groups III, IV, and VIII by ion exchangers. The ions are complex-bonded to a new type of ion exchanger consisting of the polycondensates of phenol with aldehydes or ketones and containing an atom of phosphorus, arsenic or antimony with an atom of sulphur or oxygen in a complex bond. The polymers of compounds containing a double bond, e.g., of butadiene, polyvinyl alcohol, polyethylene, polypropylene, and the compounds of styrene with fural may also be used for this purpose. The method is demonstrated on a case of uranium and heavy metal concentration and the separation thereof from waste waters. (L.K.)

Soziologische Wissenskulturen zwischen individualisierter Inspiration und prozeduraler Legitimation. Zur Entwicklung qualitativer und interpretativer Sozialforschung in der deutschen und französischen Soziologie seit den 1960er Jahren

Directory of Open Access Journals (Sweden)

Reiner Keller

2016-01-01

Full Text Available Wie wissen Soziologinnen und Soziologen, was sie wissen? Trotz der Internationalisierung der Soziologie bestehen nach wie vor starke sprachräumliche Unterschiede in der soziologischen Wissensproduktion, in eingesetzten Theorien, Methoden und Fragestellungen. Der nachfolgende Beitrag erläutert die Entwicklung und Ausprägung der Unterschiedlichkeit soziologischer Wissenskulturen im Hinblick auf den Einsatz qualitativer bzw. interpretativer Ansätze seit den 1960er Jahren in Deutschland und Frankreich. Er stützt sich auf ein von uns 2012-2014 geleitetes Forschungsprojekt und dessen empirische Grundlagen: Dokumentenanalysen und Interviews. Wissenskulturen werden als die Arten und Weisen der Produktion und Legitimation von (hier: soziologischem Wissen verstanden. Diesbezüglich lässt sich von der Erkenntnisproduktion als dem zentralen Handlungsproblem soziologischen Forschens sprechen. Während für die französischsprachige Soziologie diagnostisch von einer Lösung dieses Erkenntnisproblems durch die den Forschenden zugeschriebenen Kompetenzen und Inspirationen ausgegangen werden kann, schiebt sich im deutschsprachigen Raume eine prozedurale Legitimation durch Verfahren in den Vordergrund. Der Beitrag rekonstruiert exemplarisch die Ausgangssituation dieser Entwicklungen um die Wende zu den 1960er Jahren und bettet sie in die weitere Entfaltung der jeweiligen Soziologien ein. Er will damit zur gegenwärtigen Entwicklung einer reflexiven Soziologie beitragen. URN: http://nbn-resolving.de/urn:nbn:de:0114-fqs1601145

Neue Medien in der Lehrerausbildung. Zu angemessenen (und unangemessenen Zielen und Inhalten des Lehramtsstudiums

Directory of Open Access Journals (Sweden)

Sigrid Blömeke

2003-01-01

Full Text Available In vier Schritten wird dem Verhältnis von Lehrerausbildung und neuen Medien nachgegangen. Zunächst werden grundsätzliche medienpädagogische Aufgaben der Lehrerausbildung herausgearbeitet, bevor das Ausbildungsprofil ihrer ersten und zweiten Phase in den Blick genommen wird. Ausgangspunkt der Theoriebildung sind professions- und institutionentheoretische Ansätze, die auf die neuen Medien bezogen werden; Konkretisierungen erfolgen an Beispielen aus der Germanistik, der Anglistik, der Geschichte und der Mathematik. Anschliessend wird der Erwerb medienpädagogischer Kompetenz durch zukünftige Lehrerinnen und Lehrer von dem Erwerb basaler Medienkompetenz als eines Elements von Allgemeinbildung abgegrenzt. Zum Schluss werden Konsequenzen für die strukturelle Gestaltung der Lehrerausbildung gezogen.

Behaviour of palladium(II), platinum(IV), and rhodium(III) in artificial and natural waters: Influence of reactor surface and geochemistry on metal recovery

Energy Technology Data Exchange (ETDEWEB)

Cobelo-Garcia, Antonio [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom)]. E-mail: antonio.cobelo-garcia@plymouth.ac.uk; Turner, Andrew [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom); Millward, Geoffrey E. [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom); Couceiro, Fay [School of Earth, Ocean and Environmental Sciences, University of Plymouth, Drake Circus, Plymouth PL4 8AA (United Kingdom)

2007-03-07

The recovery of dissolved platinum group elements (PGE: Pd(II), Pt(IV) and Rh(III)) added to Milli-Q[reg] water, artificial freshwater and seawater and filtered natural waters has been studied, as a function of pH and PGE concentration, in containers of varying synthetic composition. The least adsorptive and/or precipitative loss was obtained for borosilicate glass under most of the conditions employed, whereas the greatest loss was obtained for low-density polyethylene. Of the polymeric materials tested, the adsorptive and/or precipitative loss of PGE was lowest for fluorinated ethylene propylene (Teflon[reg]). The loss of Pd(II) in freshwater was significant due to its affinity for surface adsorption and its relatively low solubility. The presence of natural dissolved organic matter increases the recovery of Pd(II) but enhances the loss of Pt(IV). The loss of Rh(III) in seawater was significant and was mainly due to precipitation, whereas Pd(II) recovery was enhanced, compared to freshwater, because of its complexation with chloride. The results have important implications regarding protocols employed for sample preservation and controlled laboratory experiments used in the study of the speciation and biogeochemical behaviour of PGE.

Selection of compressors and drives for natural gas storage and transport - technical and economic aspects; Auswahl von Verdichtern und Antriebsmaschinen fuer die Erdgasspeicherung und den Erdgastransport - technische und wirtschaftliche Aspekte

Energy Technology Data Exchange (ETDEWEB)

Heyer, F.; Wieke, S. [Heyer und Wieke Engineering, Muenchen (Germany)

1998-12-31

Selection of the proper compressor/drive combination is indispensable for optimizing natural gas storage. The contribution presents a comparison of the available systems. (orig.) [Deutsch] Fuer die Verdichtung von Erdgas fuer die Erdgasspeicherung und den Erdgastransport ist die Auswahl der fuer den jeweiligen Anwendungsfall geeigneten Verdichter-Antriebskombination eine wesentliche Voraussetzung fuer einen technisch und wirtschaftlich optimalen Betrieb. Unter Beruecksichtigung des Marktes werden die Varianten (Verdichter-Antriebskombinationen) definiert und in einem technischen Vergleich Vor- und Nachteile der einzelnen Alternativen gegenuebergestellt und bewertet. Die Einhaltung der Betriebsanforderungen und der Anforderungen der TA-Luft und TA-Laerm, der Wirkungsgrad, die Zuverlaessigkeit und Verfuegbarkeit muessen einer besonders intensiven Pruefung und Beurteilung unterzogen werden. Das Ergebnis der vergleichenden Bewertung der Varianten kann eine neue Definition der Varianten oder der Anforderungen notwendig machen. (orig.)

In vitro-Permeationsstudien von hydrophilen und lipophilen Arzneistoffen an okularen Geweben und Zellkulturen

OpenAIRE

Scholz, Martina

2003-01-01

Da die Arzneistoffpermeation durch okulare Gewebe einen entscheidenden Einfluss auf die Heilung vieler Augenleiden hat, wurde die in vitro-Permeation hydrophiler und lipophiler Arzneistoffe durch okulare Gewebe und Zellkulturen in dieser Arbeit untersucht. Die Dissertation befasst sich vorrangig mit der Permeation des hydrophilen Modellarzneistoffs Pilocarpinhydrochlorid (P-HCl) durch isolierte Schweinecornea (SC), Schweinesklera, Kaninchenkonjunktiva und corneale bzw. konjunktivale Kan...

Finanzkrise, Sozialkrise und ungleiche Entwicklung in Südkorea und Thailand

DEFF Research Database (Denmark)

Schmidt, Johannes Dragsbæk

2008-01-01

Zehn Jahre ist es inzwischen her, dass die Finanzkrisen in Südostasien, Russland und Lateinamerika die Weltwirtschaft erschütterten. Angesichts dieses "Jubiläums" und der aktuellen US-Finanzkrise ist es Zeit für eine Bestandsaufnahme: Lektionen gelernt? Drei Fragestellungen stehen im Mittelpunkt...

Electro-regeneration of Ce(IV) in real spent Cr-etching solutions

International Nuclear Information System (INIS)

Chen, Te-San; Huang, Kuo-Lin

2013-01-01

Highlights: • An electrochemical process is used to regenerate Ce(IV) in real (hazardous) spent TFT-LCD Cr-etching solutions. • The Ce(IV) yield on tested anodes was in order BDD > Pt > DSA. • A Neosepta CMX separator was better than Nafion ones to be used in the process. • The activation energy on Pt was 10.7 kJ/mol. • The obtained parameters are useful to design reactors for 100% Ce(IV) regeneration in real spent Cr-etching solutions. -- Abstract: This paper presents the electro-regeneration of Ce(IV) in real (hazardous) spent thin-film transistor liquid-crystal display (TFT-LCD) Cr-etching solutions. In addition to Ce(III) > Ce(IV) in diffusivity, a quasi-reversible behavior of Ce(III)/Ce(IV) was observed at both boron-doped diamond (BDD) and Pt disk electrodes. The Ce(IV) yield on Pt increased with increasing current density, and the best current efficiency (CE) was obtained at 2 A/2.25 cm 2 . The performance in terms of Ce(IV) yield and CE of tested anodes was in order BDD > Pt > dimensional stable anode (DSA). At 2 A/2.25 cm 2 on Pt and 40 °C for 90 min, the Ce(IV) yield, CE and apparent rate constant (k) for Ce(III) oxidation were 81.4%, 21.8% and 3.17 × 10 −4 s −1 , respectively. With the increase of temperature, the Ce(IV) yield, CE, and k increased (activation energy = 10.7 kJ/mol), but the specific electricity consumption decreased. The Neosepta CMX membrane was more suitable than Nafion-117 and Nafion-212 to be used as the separator of the Ce(IV) regeneration process. The obtained parameters are useful to design divided batch reactors for the Ce(IV) electro-regeneration in real spent Cr-etching solutions

Hopf and Bautin Bifurcation in a Tritrophic Food Chain Model with Holling Functional Response Types III and IV

Science.gov (United States)

Castellanos, Víctor; Castillo-Santos, Francisco Eduardo; Dela-Rosa, Miguel Angel; Loreto-Hernández, Iván

In this paper, we analyze the Hopf and Bautin bifurcation of a given system of differential equations, corresponding to a tritrophic food chain model with Holling functional response types III and IV for the predator and superpredator, respectively. We distinguish two cases, when the prey has linear or logistic growth. In both cases we guarantee the existence of a limit cycle bifurcating from an equilibrium point in the positive octant of ℝ3. In order to do so, for the Hopf bifurcation we compute explicitly the first Lyapunov coefficient, the transversality Hopf condition, and for the Bautin bifurcation we also compute the second Lyapunov coefficient and verify the regularity conditions.

Plazentaanatomie und -physiologie mit uteroplazentarem Kreislauf

NARCIS (Netherlands)

Engel, N.; Schreiber, J. U.; Kranke, Peter

2017-01-01

Die Plazenta besteht neben der Nabelschnur aus parenchymatösem Gewebe, der sog. Eihaut (Amnion) und der Zottenhaut (Chorion). Sie fungiert als Schnittstelle zwischen Mutter und Fetus und ermöglicht den physiologischen Transfer von Gasen, Nährstoffen und Metaboliten. Die Funktion der Plazenta ist als

Kunst und Revolution.John Berger und der sowjetische Bildhauer Ernst Neiswestni

OpenAIRE

Artinger, Kai

2011-01-01

John Berger war einer der einflussreichsten Kunstkritiker der Linken in den 1950er Jahren in Großbritannien. Er spielte eine zentrale Rolle in den Diskursen über die Situation der Kunst und ihre Zukunft. Bezeichnend für sein Kunstverständnis war es, ausgetretene Pfade zu verlassen und den herrschenden Kanon zu ignorieren. Daher erfasste sein Blick auch die osteuropäische Kunst. Seit 1953 besucht er mehrfach die UdSSR und die DDR. Als unabhängiger Marxist lehnte sich Berger an den Strategien...

Wirkungen eines Bifidojoghurts mit Laktulose und eines konventionellen Joghurts auf Darmphysiologie und bakterielle Metaboliten als Risikomodulatoren der Kolonkarzinogenese sowie Darmflora und Blutlipide bei gesunden Erwachsenen

OpenAIRE

Gerlach, Stefanie

2007-01-01

Hintergrund: Probiotische und synbiotische Milchprodukte zählen zu den "funktionellen Lebensmitteln", denen im Vergleich zu herkömmlichen Produkten ein gesundheitsfördernder Zusatznutzen zugeschrieben wird. Dabei wird diskutiert, ob die Gesundheit bereits gesunder Personen noch optimierbar ist, ob und in welcher Weise die Darmflora gezielt "günstig" modifiziert werden kann und/oder ob diese Manipulation zu messbaren gesundheitsfördernden Veränderungen metabolischer und systemischer Biomarker ...

Air quality III - experiments on emission and sensory perception of olfactory substances from ventilation systems. Final report; Luftqualitaet III - Experimentelle Untersuchungen zur Emission und Wahrnehmung von Geruchsstoffen aus Lueftungsgeraeten. Abschlussbericht

Energy Technology Data Exchange (ETDEWEB)

Fitzner, K.; Boettcher, O.

2001-08-01

Room air quality is highly important in Germany as people living here will spend 90 percent of their lives inside rooms. Air quality is defined to a large extent via the nose. This research project, in continuation of AiF 10525, involved investigations of materials and components of space HVAC systems with varying air temperatures, humidities and air flow rates for a subjective assessment of the air quality. The main goals were the definition of laws for identification of odorants and the derivation of laws for calculating pollutant-level-dependent ambient air rates for mechanically ventilated rooms. The experiments showed that both adsorption and desorption had a significant part in the addition of odorangs, causing deviations between theoretical and experimental values of felt air quality. The temperature and the relative humidity had an effect as well. Most measurements were made near the olfactory threshold, so that a number of participants were unable to complete the test. Later investigations will rely on analytical methods in addition to test persons. (orig.) [German] Das Thema der Luftqualitaet in Innenraeumen hat in Deutschland grosse Bedeutung, da sich die Bevoelkerung zu 90 Prozent ihres Lebens in Innenraeumen aufhaelt. Die Behaglichkeit der Atemluft wird in grossem Masse durch die mit der Nase wahrgenommenen Bestandteile der Luft beeinflusst. In Fortsetzung zum Forschungsvorhaben AiF 10525 wurden in diesem Forschungsvorhaben Untersuchungen mit Materialien und Komponenten aus RLT-Anlagen unter Veraenderung von Lufttemperatur, Luftfeuchte und Luftgeschwindigkeit zur subjektiven Beurteilung der Luftqualitaet durchgefuehrt. Die Hauptziele dieser Untersuchungen waren das Auffinden der Gesetzmaessigkeiten zur Wahrnehmung von Geruchsstoffen und das Ableiten von Rechenregeln zur Bestimmung verunreinigungslastabhaengiger Aussenluftraten fuer maschinell belueftete Raeume. Die Versuche zeigten, dass Adsorption und Desorption bei der Addition von Geruchsstoffen

Zwischen Freakout und Normcore

Directory of Open Access Journals (Sweden)

Beate Großegger

2017-06-01

Full Text Available Bis Ende des 20. Jahrhunderts war Rebellion jugendkulturell ein großes Thema. Heute hat die Jugend das so genannte Establishment aus den Augen verloren; die breite Mehrheit gibt sich postheroisch, setzt auf individualitätsbezogene Werte und träumt, eingeschlossen in ihre bunten Lifestyleblasen, von einem perfekten Leben. Bezugnehmend auf aktuelle Befunde der Jugend- und Generationenforschung gibt Beate Großegger in ihrem Beitrag einen Überblick über die wichtigsten Werte- und Lifestyletrends im frühen 21. Jahrhundert und zeigt dabei, wie sehr die heutige Jugend Kind ihrer Zeit und Produkt gesellschaftlicher Rahmenbedingungen ist. Until the late 20th century rebellion was an important aspect of various youth subcultures. But today’s youth has a different mindset. The majority acts post-heroically, i.e. they rather focus on their individual, their private lifestyle than opposing against the establishment. Wrapped in their lifestyle filterbubbles, they dream of a perfect life. Based on recent youth und generation studies Beate Großegger gives an overview of the most important youth cultural trends in the fields of values and lifestyles and introduces today’s youth as a child of our times.

Die Werte der Wertvermittler - Berufliches Rollenselbstverständnis und Weltanschauung von Journalistinnen und Journalisten

Directory of Open Access Journals (Sweden)

Andy Kaltenbrunner

2010-09-01

Full Text Available Der Beitrag analysiert professionelles Selbstverständnis, Weltanschauungen und ethische Überzeugungen von Journalistinnen und Journalisten in Österreich. Auf Basis aktueller Befragungen und Studien wird die Grundstruktur des journalistischen Wertesystems skizziert und der Zusammenhang mit täglicher Berichterstattung. Der Beitrag diskutiert mögliche Konsequenzen für Zukunft des Journalismus und Qualität der Öffentlichkeit. The article focuses on the professional values, political views and ethical beliefs of Austrian journalists. Based on recent surveys we outline the basic structure of the journalistic value system in Austria and the interdependence of these values and actual reporting and we discuss possible consequences for the future of journalism as a profession and for the quality of the public sphere.

Supraleitung Grundlagen und Anwendungen

CERN Document Server

Buckel, Werner

2013-01-01

Grundlegende Konzepte und Eigenschaften von Supraleitern, die Herstellung und Entwicklung von neuen supraleitenden Materialien sowie moderne Anwendungsbereiche sind die Schwerpunktthemen des Buches. Das größte Potential zur Nutzung der Supraleitung liegt in der Energietechnik. Fast unbemerkt trägt die Einführung von Kabeln, Magneten, Transformatoren oder Lagern aus supraleitenden Materialien bei zur Effizienzsteigerung bei der Stromübertragung oder in Motoren. Durch seiner klare Sprache und zahlreiche erläuternde Abbildungen eignet sich der Band hervorragend als einführendes Lehrbuch. Der Schwierigkeitsgrad wird von Kapitel zu Kapitel gesteigert. So können auch Einsteiger ohne einschlägige Vorkenntnisse dem Stoff folgen. Dank der über 350 Literaturhinweise bekommt der Leser außerdem einen Überblick über die wichtigsten Publikationen zum Thema. Ein unverzichtbares Lehrbuch also für Physik-Studenten und Studierende der Ingenieurwissenschaften. Fachleuten in Forschung und Praxis leistet das Buch au...

Editorial: Theoriebildung in Mediendidaktik und Wissensmanagement

Directory of Open Access Journals (Sweden)

Michael Kerres

2002-10-01

Full Text Available Das Internet trägt massgeblich zur Entstehung einer neuen Lern- und Wissenskultur bei und ist mittlerweile Gegenstand einer ganzen Reihe von Projekten in der Erziehungswissenschaft. So wird zum Beispiel der Frage nachgegangen, welche Möglichkeiten der Strukturierung und Gestaltung von Lernmaterialien am besten geeignet sind, um Lernprozesse anzuregen, wie die interpersonale Kommunikation im Internet durch didaktische Gestaltungsmassnahmen gefördert werden können oder wie die entfernte Betreuung von Lernenden über das Netz funktioniert. Zunehmend wird dabei auch der Übergang bedeutsam zwischen didaktisch aufbereiteten Lernangeboten, wie sie die Mediendidaktik traditionell beschäftigt, und dem Austausch von nicht didaktisch aufbereiteten Informationen in Organisationen, wie es im Bereich des Wissensmanagements diskutiert wird. In diesen Projekten werden vielfach Detailfragen behandelt, und isoliert, ohne Bezug zu grundlegenden Theoriefragen untersucht. Es mangelt an einer genuin mediendidaktischen Theoriediskussion, die einen übergreifenden Bezugsrahmen aus erziehungswissenschaftlicher Perspektive liefert. In der Vergangenheit ist die Mediendidaktik von Seiten einer «kritischen» Medienpädagogik zeitweise skeptisch beäugt und in ihrer Existenz grundlegend infrage gestellt worden. In der aktuellen Diskussion wird gerne auf lerntheoretische Ansätze zurückgegriffen, die Lernen als aktiven Vorgang der individuellen und kooperativen Wissenskonstruktion begreifen. Doch Wissens- und Lerntheorien ersetzen keine mediendidaktische Modell- und Theoriebildung, die Perspektiven für eine Gestaltung zukünftiger Lernwelten liefert und dabei zum Beispiel sowohl bildungstheoretische Überlegungen als auch Konzepte des instructional design einbezieht. In dem ersten Teil dieser Ausgabe geht es um theoretische Perspektiven der Mediendidaktik. So diskutiert der Artikel von Michael Kerres und Claudia de Witt den Beitrag der Positionen von Behaviorismus

Das IHS und die Rolle der Forschungsinstitute

OpenAIRE

Keuschnigg, Christian

2014-01-01

Das Institut für Höhere Studien und wissenschaftliche Forschung (IHS) ist ein unabhängiges Forschungsinstitut und leistet Forschung und Ausbildung auf Spitzenniveau für Politik, Wirtschaft und Gesellschaft. Im Wettbewerb zwischen Universitäten und angewandten Forschungsinstituten ist das IHS einzigartig, weil es unter einem Dach Grundlagenforschung und forschungsnahe Lehre mit angewandter Forschung für die wissenschaftliche Politikberatung verbindet. Mit den drei Disziplinen Ökonomie, Soziolo...

Patterns of failure of diffuse large B-cell lymphoma patients after involved-site radiotherapy

Energy Technology Data Exchange (ETDEWEB)

Holzhaeuser, Eva; Berlin, Maximilian; Bezold, Thomas; Mayer, Arnulf; Schmidberger, Heinz [University Medical Center Mainz, Department of Radiation Oncology and Radiotherapy, Mainz (Germany); Wollschlaeger, Daniel [University Medical Center Mainz, Institute for Medical Biostatistics, Epidemiology and Informatics, Mainz (Germany); Hess, Georg [University Medical Center Mainz, Department of Internal Medicine, Mainz (Germany)

2017-12-15

no marginal failures occurred. The concept of IS will likely reduce the risk for late sequelae of RT. (orig.) [German] Die konsolidierende Radiotherapie (RT) in Kombination mit einer Chemoimmuntherapie stellt eine hocheffiziente Therapiemethode in der Behandlung des diffusen grosszelligen B-Zell-Lymphoms (DLBCL) dar. Die vorliegende retrospektive Analyse evaluiert die Effektivitaet und Sicherheit des Volumen- und Dosiskonzepts der ''Involved-site''-Radiotherapie (ISRT). Wir identifizierten 60 Patienten mit histologisch gesichertem DLBCL im Stadium I-IV, die zwischen Januar 2005 und Dezember 2015 mit einer Chemoimmuntherapie und konsolidierender ISRT behandelt wurden. Progressionsfreies (PFS) und Gesamtueberleben (OS) wurden mittels Kaplan-Meier-Methode dargestellt und univariate Analysen mittels Log-rank-Test und Mann-Whitney-U-Test erhoben. Nach einer initialen Chemoimmuntherapie (ueberwiegend R-CHOP; Rituximab, Cyclophosphamid, Doxorubicin, Vincristin und Prednisolon) erzielten 19 Patienten (36 %) eine komplette (CR) und 34 (64 %) eine partielle Remission (PR) oder weniger. Ausgeschlossen wurden 7 Patienten (12 %) mit einem Progress nach Chemoimmuntherapie. Alle Patienten erhielten eine ISRT mit 40 Gy Gesamtdosis. Nach einer medianen Nachbeobachtungszeit von 44 Monaten waren 79 % der Patienten erkrankungsfrei, waehrend 21 % ein Rezidiv oder einen systemischen Progress erlitten oder verstarben. Alle Patienten mit CR nach Chemoimmuntherapie blieben nach konsolidierender ISRT in CR. Bei 2 Patienten mit PR nach Chemoimmuntherapie trat ein Rezidiv an Stelle der initialen Laesion innerhalb des IS-Planungszielvolumens (PTV) auf. Feldrandrezidive wurden nicht beobachtet. Ein signifikant verbessertes PFS zeigten ein Ann-Arbor-Stadium I/II im Vergleich zu Stadium III/IV (93 % vs. 65 %; p ≤ 0,021) sowie ein internationaler prognostischer Index (IPI) von 0 oder 1 verglichen mit 2-5 (100 % vs. 70 %; p ≤ 0,031). Der Post-Chemoimmuntherapie-Status einer CR

3D MRI of the colon: methods and first results of 5 patients; 3D-MRT des Kolons: Methodik und erste Ergebnisse

Energy Technology Data Exchange (ETDEWEB)

Luboldt, W; Bauerfeind, P; Pelkonen, P; Steiner, P; Krestin, G P; Debatin, J F [MRI-Zentrum, Dept. Diagnostische Radiologie, Universitaetsspital, Zurich (Switzerland)

1997-09-01

Purpose: `Exoscopic` and endoscopic identification of colorectal pathologies via MRI. Methods: 5 patients (36-88 years), two normal and three with different colorectal pathologies (diverticular disease, polyps and carcinoma of the colon), were examined by MRI after colonoscopy. Subsequent to filling of the colon with a gadolinium-water mixture under MRI-monitoring, 3D-data sets of the colon were acquired in prone and supine positions over a 28 sec breathold interval. Subsequently multiplanar T{sub 1}-weighted 2D-sequences were acquired before and following i.v. administration of Gd-DTPA (0.1 mmol/kg BW). All imaging was performed in the coronal orientation. The 3D-data were interactively analysed based on various displays: Maximum intensity projection (MIP), surface shadowed display (SSD), multiplanar reconstruction (MPR), virtual colonoscopy (VC). Results: All of the colorectal pathologies could be interactively diagnosed by MPR. On MIP images some pathologies were missed. VC presented the morphology of colon haustra as well as of all endoluminally growing lesions in a manner similar to endoscopy. The colon masses showed uptake of contrast media and could thus be differentiated from air or faeces. (orig./AJ) [Deutsch] Ziel: Externe und endoskopische Identifizierung kolorektaler Pathologien mittels MRT. Material und Methoden: 5 Patienten (36-88 Jahre), zwei mit Normalbefund, drei mit verschiedenen kolorektalen pathologischen Befunden (Divertikulose, Polypen, Karzinom), wurden nach der Kolonoskopie mit der MRT untersucht. Dazu wurde das Kolon unter MR-Sichtkontrolle mit einer Gadolinium-Wasser-Mischung gefuellt und als 3D-Datensatz atemangehalten in Bauch- und Rueckenlage aufgenommen. Anschliessend wurden multiplanare, T{sub 1}-gewichtete 2D-Sequenzen vor und nach i.v. Gd-DTPA-Gabe akquiriert. Die 3D-Datensaetze wurden interaktiv unter Zuhilfenahme verschiedener Darstellungsformen analysiert: Maximale Intensitaetsprojektion (MIP), Oberflaechendarstellung

Cancer in the oropharynx: Cost calculation of different treatment modalities for controlled primaries, relapses and grade III/IV complications

International Nuclear Information System (INIS)

Nijdam, Wideke; Levendag, Peter; Noever, Inge; Groot, Carin Uyl-de; Agthoven, Michel van

2005-01-01

Background and purpose: This paper presents a model for cost calculation using the different treatment modalities for oropharyngeal (OPh) cancers used in our hospital. We compared full hospital costs, the associated costs of localregional relapses (LRR) and/or treatment related grade III/IV complications. Materials and methods: Patients with OPh cancer are treated in the Erasmus MC preferably by an organ function preservation protocol. That is, by external beam radiation therapy (EBRT) followed by a brachytherapy (BT) boost, and neck dissection in case of N+ disease (BT-group: 157 patients). If BT is not feasible, resection with postoperative EBRT (S-group [S=Surgery]: 110 patients) or EBRT-alone (EBRT-group: 77 patients) is being pursued. Actuarial localregional control (LRC), disease free survival (DFS) and overall survival (OS) at 5-years were calculated according to the Kaplan-Meier method. The mean costs per treatment group for diagnosis, primary Tx per se, follow-up, (salvage of) locoregional relapse (LRR), distant metastasis (DM), and/or grade III/IV complications needing clinical admission, were computed. Results: For the BT-, S-, or EBRT treatment groups, LRC rates at 5-years were 85, 82, and 55%, for the DFS, 61, 48, and 43%, and for the OS 65, 52, and 40%, respectively. The mean costs of primary Tx in case of the BT-group is EURO 13,466; for the S-group EURO 24,219, and EURO 12,502 for the EBRT-group. The mean costs of S (the main salvage modality) for a LRR of the BT group or EBRT-group, were EURO 17,861 and EURO 15,887, respectively. The mean costs of clinical management of Grade III/IV complications were EURO 7184 (BT-group), EURO 16,675 (S-group) and EURO 6437 (EBRT-group). Conclusion: The clinical outcome illustrates excellent LRC rates at 5-years for BT (85%), as well as for S (82%). The relatively low 55% LRC rate at 5-years for EBRT probably reflects a negative selection of patients. It is of interest that the total mean costs of patients alive

MODERATE C IV ABSORBER SYSTEMS REQUIRE 1012 M☉ DARK MATTER HALOS AT z ∼ 2.3: A CROSS-CORRELATION STUDY OF C IV ABSORBER SYSTEMS AND QUASARS IN SDSS-III BOSS DR9

International Nuclear Information System (INIS)

Vikas, Shailendra; Wood-Vasey, W. Michael; Lundgren, Britt; Ross, Nicholas P.; Myers, Adam D.; AlSayyad, Yusra; York, Donald G.; Schneider, Donald P.; Brinkmann, J.; Bizyaev, Dmitry; Brewington, Howard; Malanushenko, Elena; Malanushenko, Viktor; Oravetz, Daniel; Pan, Kaike; Snedden, Stephanie; Ge, Jian; Muna, Demitri; Pâris, Isabelle; Petitjean, Patrick

2013-01-01

We measure the two-point cross-correlation function of C IV absorber systems and quasars, using spectroscopic data from the Sloan Digital Sky Survey III Baryon Oscillation Spectroscopic Survey (BOSS; Data Release 9). The 19,701 quasars and 6149 C IV ''moderate'' absorbers, 0.28 Å 2 and represent a factor of two increase in sample size over previous investigations. We find a correlation scale length and slope of the redshift-space cross-correlation function of s 0 = 8.46 ± 1.24 Mpc, γ = 1.68 ± 0.19, in the redshift-space range 10 0 = 7.76 ± 2.80 Mpc, γ = 1.74 ± 0.21. We measure the combined quasar and C IV bias to be b QSO b C I V = 8.81 ± 2.28. Using an estimate of b QSO from the quasar auto-correlation function we find b CIV = 2.38 ± 0.62. This b CIV implies that EW > 0.28 Å C IV absorbers at z ∼ 2.3 are typically found in dark matter halos that have masses ≥10 11.3 -10 13.4 M ☉ at that redshift. The complete BOSS sample will triple the number of both quasars and absorption systems and increase the power of this cross-correlation measurement by a factor of two.

Solidarität und Heterogenität in Gruppen: Theoretische und empirische Skizzen

Directory of Open Access Journals (Sweden)

Irma Rybnikova

2015-03-01

Full Text Available Für gewöhnlich wird Heterogenität der Gruppen als Hindernis für Solidarität ihrer Mitglieder angesehen: Je verschiedener die Mitglieder, umso schwieriger kommt Solidarität zustande. In der vorliegenden Studie hinterfrage ich diese Generalisierung, indem ich eine Reihe von theoretischen Ansätzen aus der Soziologie und der Gruppenpsychologie konsultiere. Während einige dieser Ansätze nahelegen, dass Heterogenität der Mitglieder die Solidarität der Gruppen untergräbt, bestreiten dies andere Ansätze und gehen davon aus, dass auch heterogene Gruppen solidarisch sein können, vor allem dann, wenn unter den Mitgliedern eine Interdependenz vorliegt. Diese widersprüchlichen theoretischen Annahmen animierten mich zu einer empirischen Untersuchung von Studierendengruppen in einer Lehrveranstaltung. Die Ergebnisse zeigen zwar, dass zwischen Heterogenität und Solidarität in den interdependenten Gruppen ein Zusammenhang anzunehmen ist, dass jedoch auch eine Ambivalenz besteht zwischen individueller und Kollegensolidarität. Vor dem Hintergrund der theoretischen und empirischen Erkenntnisse diskutiere ich Schlussfolgerungen für die Forschung und für die praktischen Bemühungen der Solidarisierung im Bereich der gewerkschaftlichen Organisierung.

Gedenken, Geschichte und Versöhnung in Südafrika und Zimbabwe

OpenAIRE

Marx, Christoph

2006-01-01

'Die Gesellschaft Südafrikas hat sich nach der Überwindung der Apartheid mit der Einrichtung einer Wahrheits- und Versöhnungskommission auf eine wichtige öffentliche Debatte über ihre Vergangenheit eingelassen. Der Kontext dieser Debatte und die Vorgabe, dass die Beschäftigung mit der Vergangenheit in die Bildung einer neuen Nation münden solle, führten indes dazu, dass sich neue Formen von Inklusion und Exklusion entwickelten. Da Identität nur über die Betonung von Differenz möglich ist, läs...

First principles calculation of material properties of group IV elements and III-V compounds

Science.gov (United States)

Malone, Brad Dean

This thesis presents first principles calculations on the properties of group IV elements and group III-V compounds. It includes investigations into what structure a material is likely to form in, and given that structure, what are its electronic, optical, and lattice dynamical properties as well as what are the properties of defects that might be introduced into the sample. The thesis is divided as follows: • Chapter 1 contains some of the conceptual foundations used in the present work. These involve the major approximations which allow us to approach the problem of systems with huge numbers of interacting electrons and atomic cores. • Then, in Chapter 2, we discuss one of the major limitations to the DFT formalism introduced in Chapter 1, namely its inability to predict the quasiparticle spectra of materials and in particular the band gap of a semiconductor. We introduce a Green's function approach to the electron self-energy Sigma known as the GW approximation and use it to compute the quasiparticle band structures of a number of group IV and III-V semiconductors. • In Chapter 3 we present a first-principles study of a number of high-pressure metastable phases of Si with tetrahedral bonding. The phases studied include all experimentally determined phases that result from decompression from the metallic beta-Sn phase, specifically the BC8 (Si-III), hexagonal diamond (Si-IV), and R8 (Si-XII). In addition to these, we also study the hypothetical ST12 structure found upon decompression from beta-Sn in germanium. • Our attention is then turned to the first principles calculations of optical properties in Chapter 4. The Bethe-Salpeter equation is then solved to obtain the optical spectrum of this material including electron-hole interactions. The calculated optical spectrum is compared with experimental data for other forms of silicon commonly used in photovoltaic devices, namely the cubic, polycrystalline, and amorphous forms. • In Chapter 5 we present

Hinkelbeinchen und "little chicken's leg": deutsche und amerikanische Idiome als kommunikative Textsorten-Problematik

Directory of Open Access Journals (Sweden)

Martin Wierschin

1998-12-01

Full Text Available Als Marin Luther 1522 seine Übersetzung des Neuen Testaments nach der griechischen Edition des Erasmus von Rotterdam abschloß, hatte er dabei zwar mit größtem Sprachgefühl nicht nur dem deutschen, sondem auch dem idiomatischen 'logos' des Griechischen "auf das Maul" gesehen. Aber er mußte in seinem "Sendbrief vom Dolmetschen" 1530 dennoch zugeben, daß selbst er - zusammen mit seinen beiden Assistenten Melanchthon und Aurogallus - sehr oft zwei bis vier Wochen lang nach einem einzigen idiomatisch treffenden Wort zu suchen hatte. Damit wird von einem eminenten Kronzeugen, nämlich vom Schöpfer des protestantischen 'Hausbuches' Lutherbibel und vom eigentlichen Begründer einer einheitlichen deutschen Schrift­ sprache, samt ihrer sprach- und literargeschichtlich wirkungsmächtigen Idiomatik, die Schwierigkeit und Problematik idiomatischer Äquivalenzen und Transferenzen zwischen den Einzelsprachen verbürgt.

Separation of Cr(III) from Cr(VI) by Triton X-100 Cerium (Iv) Phosphate as a Surface Active Ion Exchanger

International Nuclear Information System (INIS)

El-Azony, K.M.; Ismail Aydia, M.; El-Mohty, A.A.

2010-01-01

A new and simple high-performance liquid chromatography (HPLC) method with ultraviolet (UV) detection has been developed for the determination of both Cr (III) and Cr (VI) ions. Chromium species were determined by HPLC using a stationary phase consisting of a reversed phase column (Nucleosil phenyl column; 250 mm x 4.6 mm,5 μm), and a mobile phase consisting of a mixture of methanol: water(70 : 30 v/v), in which the complexing agent di-(2-ethylhexyl) phosphoric acid (DEHPA) was dissolved. The UV detection was carried out at wavelength 650 nm. Separation of Cr (III) from Cr (VI) on Triton X-100 cerium(IV) phosphate(TX-100 CeP) as a surface active ion exchanger was investigated. TX-100 CeP has been synthesized, characterized using IR, X-Ray, TGA/DTA and elemental analysis. The ion exchange capacity and chemical stability in different HCl concentration have been studied

Medienbildung und Schulkultur. Implikationen der Verbindung von Medienbildung und Schulkultur für die Medienpädagogik

Directory of Open Access Journals (Sweden)

Nina Grünberger

2017-08-01

Full Text Available Gegenwärtig werden häufig Fragen nach der Konstituierung der Medienpädagogik als Disziplin gestellt und Antwortversuche aus je unterschiedlicher Perspektive formuliert. Der vorliegende Beitrag unternimmt einen solchen Versuch durch die Diskussion von Implikationen weitreichender Medialisierungsprozesse für die «Disziplinierung» der Medienpädagogik und ihrer Forschungsfelder am Beispiel von Schule als genuin pädagogischem Ort. Die Zusammenführung einer poststrukturalistisch gedachten Medienbildung und einer damit einhergehenden Entdichotomisierung von Subjekt und Welt respektive Subjekt und Medien mit dem Konzept der Schulkultur und einem damit verbundenen holistischen Blick auf das Schulgefüge eröffnet eine neue, produktive und gleichsam kritische Perspektive, ohne dabei jeweils auf eine vereinfachte Gesellschaftskritik zurück zu fallen. Dies stellt bisherige medienpädagogische Theoreme und insbesondere das Medienkompetenzkonzept, das über den medienpädagogischen Wirkungskreis hinaus auch in anderen Kontexten etabliert ist, in Frage. So wird eine neue Perspektive auf Medienpädagogik und ihre Ziele eröffnet, die nicht vorschnell in Abgrenzungsmechanismen unterschiedlicher medienpädagogischer Schulen verfällt, sondern zu aller erst eine «offene» sein will.

Fotografie und atomare Katastrophe

OpenAIRE

Bürkner, Daniel

2015-01-01

Die Dissertation setzt sich mit den fotografischen Repräsentationen der Atombombenabwürfe auf Hiroshima und Nagasaki sowie der Havarie des Kernkraftwerks Tschernobyl auseinander. Dabei werden künstlerische, dokumentarische und touristische Bilder analysiert, die sich der jeweiligen Strahlenkatastrophe oftmals erst Jahre nach dem Ereignis annehmen und ikonografische oder medial-materielle Bezüge zu ihr aufweisen. Es zeigen sich zentrale Strategien, atomare Katastrophen, seien sie militäri...

Radiation protection in category III large gamma irradiators; Radioprotecao em irradiadores de grande porte de categoria III

Energy Technology Data Exchange (ETDEWEB)

Costa, Neivaldo; Furlan, Gilberto Ribeiro, E-mail: neivaldo@cena.usp.b, E-mail: gilfurlan@cena.usp.b [Centro de Energia Nuclear na Agricultura (CENA/USP), Piracicaba, SP (Brazil); Itepan, Natanael Marcio, E-mail: natanael.itepan@unianhanguera.edu.b [Universidade Anhanguera, Goiania, GO (Brazil)

2011-07-01

This article discusses the advantages of category III large gamma irradiator compared to the others, with emphasis on aspects of radiological protection, in the industrial sector. This category is a kind of irradiators almost unknown to the regulators authorities and the industrial community, despite its simple construction and greater radiation safety intrinsic to the model, able to maintain an efficiency of productivity comparable to those of category IV. Worldwide, there are installed more than 200 category IV irradiators and there is none of a category III irradiator in operation. In a category III gamma irradiator, the source remains fixed in the bottom of the tank, always shielded by water, negating the exposition risk. Taking into account the benefits in relation to radiation safety, the category III large irradiators are highly recommended for industrial, commercial purposes or scientific research. (author)

Rosetta und Yella

Directory of Open Access Journals (Sweden)

Urs Urban

2009-11-01

Full Text Available L’apparition de l’homo oeconomicus marque la fin des grands récits et par là de l’ensemble social que ceux-ci avaient légitimé. En même temps cependant il entre dans les récits littéraires – et filmiques, par exemple dans Rosetta (1999 des frères Dardenne et Yella (2007 de Christian Petzold. L’article se propose de montrer comment ces derniers réussissent à mettre en scène les apories existentielles d’un sujet produit par le dispositif économique en appliquant des procédés narratifs permettant de problématiser la narration elle-même.Mit dem Auftauchen des homo oeconomicus scheint das Ende der großen Erzählungen und des von diesen legitimierten sozialen Zusammenhangs besiegelt. Genau in diesem Moment indes beginnen sich die kleinen, die literarischen und filmischen Erzählformen für den ökonomischen Menschen zu interessieren. In dem Artikel geht es darum zu zeigen, wie die Brüder Dardenne und Christian Petzold die Aporien eines vom ökonomischen Dispositiv produzierten Subjekts in ihren Filmen Rosetta (1999 und Yella (2007 erzählerisch umsetzen und dabei genau diese erzählerische Umsetzbarkeit in Frage stellen.

Ethik, Recht und Theologie. Reproduktionstechnologien in Polen

Directory of Open Access Journals (Sweden)

Susanne Lettow

2006-03-01

Full Text Available Die bisherigen Debatten um Stammzellforschung, Klonen und Reproduktionstechnologien wurden in Deutschland weitgehend im nationalstaatlichen Rahmen und mit Blick auf Entwicklungen im angelsächsischen Raum geführt. Dabei sind diese Forschungsrichtungen und Technologien kein genuin „westliches“ Phänomen – immerhin wurde das erste Retortenkind in Polen bereits 1987 geboren. Heidi Hofmann lässt in ihrem Band polnische Philosoph/-innen, Jurist/-innen und Politikerinnen zu Wort kommen und öffnet den Blick dafür, dass die Art und Weise, in der Reproduktionstechnologien gesellschaftlich problematisiert werden, in Polen durch ganz andere politische, kulturelle und historische Konstellationen geprägt ist als in Deutschland.

Ein überfälliger Dialog. Wie Frauen- und Geschlechterforschung und Soziologie miteinander ins Gespräch kommen können

Directory of Open Access Journals (Sweden)

Heike Kahlert

2007-03-01

Full Text Available Die Monographie von Brigitte Aulenbacher zum Zusammenhang von Rationalisierung, Geschlecht und Gesellschaft ist in gegenstandsbezogener und methodologischer Hinsicht ambitioniert, überzeugend und lesenswert. Die Studie stellt eine solide, manchmal auch etwas zu weitschweifige und detailreiche Grundlage für weiterführende Diskussionen zwischen der (sozialwissenschaftlichen Frauen- und Geschlechterforschung und der Soziologie, genauer der Gesellschaftstheorie in zeitdiagnostischer Perspektive, Arbeits-, Industrie-, Organisations- und Techniksoziologie, dar.

Activation of the CXCR3 chemokine receptor through anchoring of a small molecule chelator ligand between TM-III, -IV, and -VI

DEFF Research Database (Denmark)

Rosenkilde, Mette M; Andersen, Michael B; Nygaard, Rie

2006-01-01

modeling and molecular simulations combined with mutational analysis indicated that the metal ion site-anchored chelators act as agonists by establishing an aromatic-aromatic, second-site interaction with TyrVI:16 on the inner face of TM-VI. It is noteworthy that this interaction required......Seven transmembrane segment (7TM) receptors are activated through a common, still rather unclear molecular mechanism by a variety of chemical messengers ranging from monoamines to large proteins. By introducing a His residue at position III:05 in the CXCR3 receptor a metal ion site was built...... between the extracellular ends of transmembrane (TM) III and TM-IV to anchor aromatic chelators at a location corresponding to the presumed binding pocket for adrenergic receptor agonists. In this construct, free metal ions had no agonistic effect in accordance with the optimal geometry of the metal ion...

Expanding the Therapeutic Potential of the Iron Chelator Deferasirox in the Development of Aqueous Stable Ti(IV) Anticancer Complexes.

Science.gov (United States)

Loza-Rosas, Sergio A; Vázquez-Salgado, Alexandra M; Rivero, Kennett I; Negrón, Lenny J; Delgado, Yamixa; Benjamín-Rivera, Josué A; Vázquez-Maldonado, Angel L; Parks, Timothy B; Munet-Colón, Charlene; Tinoco, Arthur D

2017-07-17

The recent X-ray structure of titanium(IV)-bound human serum transferrin (STf) exhibiting citrate as a synergistic anion reveals a difference in Ti(IV) coordination versus iron(III), the metal endogenously delivered by the protein to cells. This finding enriches our bioinspired drug design strategy for Ti(IV)-based anticancer therapeutics, which applies a family of Fe(III) chelators termed chemical transferrin mimetic (cTfm) ligands to inhibit Fe bioavailability in cancer cells. Deferasirox, a drug used for iron overload disease, is a cTfm ligand that models STf coordination to Fe(III), favoring Fe(III) binding versus Ti(IV). This metal affinity preference drives deferasirox to facilitate the release of cytotoxic Ti(IV) intracellularly in exchange for Fe(III). An aqueous speciation study performed by potentiometric titration from pH 4 to 8 with micromolar levels of Ti(IV) deferasirox at a 1:2 ratio reveals exclusively Ti(deferasirox) 2 in solution. The predominant complex at pH 7.4, [Ti(deferasirox) 2 ] 2- , exhibits the one of the highest aqueous stabilities observed for a potent cytotoxic Ti(IV) species, demonstrating little dissociation even after 1 month in cell culture media. UV-vis and 1 H NMR studies show that the stability is unaffected by the presence of biomolecular Ti(IV) binders such as citrate, STf, and albumin, which have been shown to induce dissociation or regulate cellular uptake and can alter the activity of other antiproliferative Ti(IV) complexes. Kinetic studies on [Ti(deferasirox) 2 ] 2- transmetalation with Fe(III) show that a labile Fe(III) source is required to induce this process. The initial step of this process occurs on the time scale of minutes, and equilibrium for the complete transmetalation is reached on a time scale of hours to a day. This work reveals a mechanism to deliver Ti(IV) compounds into cells and trigger Ti(IV) release by a labile Fe(III) species. Cellular studies including other cTfm ligands confirm the Fe(III) depletion

[Geisteswissenschaft und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts] / Manfred von Boetticher

Index Scriptorium Estoniae

Boetticher, Manfred von, 1947-

2012-01-01

Arvustus: Geisteswissenschaft und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts (Schriften der Baltischen Historischen Kommission, 17; Baltische Biographische Forschungen, 1). Hrsg. von Norbert Angermann, Wilhelm Lenz und Konrad Maier. (Berlin: LIT-Varlag, 2011)

Complexation of trivalent actinides and lanthanides with hydrophilic N-donor ligands for Am(III)/Cm(III) and An(III)/Ln(III) separation; Komplexierung von trivalenten Actiniden und Lanthaniden mit hydrophilen N-Donorliganden zur Am(III)/Cm(III)- bzw. An(III)/Ln(III)-Trennung

Energy Technology Data Exchange (ETDEWEB)

Wagner, Christoph

2017-07-24

The implementation of actinide recycling processes is considered in several countries, aiming at the reduction of long-term radiotoxicity and heat load of used nuclear fuel. This requires the separation of the actinides from the fission and corrosion products. The separation of the trivalent actinides (An(III)) Am(III) and Cm(III), however, is complicated by the presence of the chemically similar fission lanthanides (Ln(III)). Hydrophilic N-donor ligands are employed as An(III) or Am(III) selective complexing agents in solvent extraction to strip An(III) or Am(III) from an organic phase loaded with An(III) and Ln(III). Though they exhibit excellent selectivity, the complexation chemistry of these ligands and the complexes formed during solvent extraction are not sufficiently characterized. In the present thesis the complexation of An(III) and Ln(III) with hydrophilic N-donor ligands is studied by time resolved laser fluorescence spectroscopy (TRLFS), UV/Vis, vibronic sideband spectroscopy and solvent extraction. TRLFS studies on the complexation of Cm(III) and Eu(III) with the Am(III) selective complexing agent SO{sub 3}-Ph-BTBP (tetrasodium 3,3{sup '},3'',3{sup '''}-([2,2{sup '}-bipyridine]-6,6{sup '}-diylbis(1,2,4-triazine-3,5,6-triyl)) tetrabenzenesulfonate) revealed the formation of [M(SO{sub 3}-Ph-BTBP){sub n}]{sup (4n-3)-} complexes (M = Cm(III), Eu(III); n = 1, 2). The conditional stability constants were determined in different media yielding two orders of magnitude larger β{sub 2}-values for the Cm(III) complexes, independently from the applied medium. A strong impact of ionic strength on the stability and stoichiometry of the formed complexes was identified, resulting from the stabilization of the pentaanionic [M(SO{sub 3}-Ph-BTBP){sub 2}]{sup 5-} complex with increasing ionic strength. Thermodynamic studies of Cm(III)-SO{sub 3}-Ph-BTBP complexation showed that the proton concentration of the applied medium impacts

Topotactic oxidation of TiGaPO-1, a pyridine-templated titanium gallophosphate with a new octahedral-tetrahedral 3-D framework structure containing Ti(III)/Ti(IV).

Science.gov (United States)

Chippindale, Ann M; Grimshaw, Mark R; Powell, Anthony V; Cowley, Andrew R

2005-06-13

The first 3-D open-framework TiGaPO complex, constructed from Ti(III)O(6), Ti(IV)O(6), GaO(4), and PO(4) polyhedra, contains pyridinium cations in a 1-D pore network and can be oxidized in air at 543 K with retention of the original framework structure.

[Geisteswissenschaften und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts] / Gert von Pistohlkors

Index Scriptorium Estoniae

Pistohlkors, Gert von, 1935-

2013-01-01

Arvustus: Geisteswissenschaften und Publizistik im Baltikum des 19. und frühen 20. Jahrhunderts. Hrsg. von Norbert Angermann, Wilhelm Lenz und Konrad Maier. (Schriften der Baltischen Historischen Kommission, Bd. 17; Baltische Biographische Forschungen, Bd. 1.) Lit. Münster 2011

Rasterelektronenmikroskopische und immunhistochemische Untersuchungen am Eileiter vom Schwein während Zyklus und Trächtigkeit

OpenAIRE

Mayer, Judith

2008-01-01

In der vorliegenden Arbeit wurden zum einen mit Hilfe des Rasterelektronenmikroskops die morphologischen Veränderungen des Eileiterepithels und zum anderen die Expression hypophysärer wachstums- und proliferationsfördernder Hormone und ihrer Rezeptoren immunhistochemisch und mit der Reverse Transkriptase (RT)-PCR sowohl im Verlauf des Zyklus als auch der Trächtigkeit analysiert. Hierfür wurden, von 24 Schweinen der Deutschen Landrasse, die drei Abschnitte des Eileiters (Infundibulum, Ampulle,...

An original accelerated radiotherapy schedule in stage III to IV head and neck cancers. Results in a multicenter setting

International Nuclear Information System (INIS)

Allal, A.S.

2000-01-01

Background: Accelerated radiotherapy delivery has recently been shown to be effective in overcoming repopulation during fractionated radiotherapy. The therapeutic ratio may be particularly favorable for 5-week regimens. This study reports the feasibility and results of a particular accelerated schedule in Stage III to IV head and neck carcinomas used in a multicenter setting. Patients and Methods: Seventy-four patients with Stage III (26 patients) or IV (48 patients) head and neck carcinomas were treated with a 5-week accelerated schedule (69.9 to 69.8 Gy in 41 to 40 fractions over a period of 35 to 36 days). Treatment began with 20 Gy in 10 daily fractions to initial involved sites, followed by bi-fractionated radiotherapy (2x1.6 Gy to 1.66 Gy/day) to a larger head and neck volume. Thirty-six (49%) patients received induction chemotherapy (median 3 cycles, range 1 to 4 cycles). Results: Grade 3 or 4 (RTOG) confluent mucositis was observed in 57 patients (77%) and Grade 3 dysphagia in 33 patients (44%). Grade 3 or 4 (RTOG-EORTC) late complications were scored in 10.5% of cases. The 5-year actuarial locoregional control rate was 56% (95% CI: 42 to 71). The 5-year overall actuarial survival was 32% (95% CI: 18 to 46). Induction chemotherapy was not associated with a more favorable outcome. Conclusions: This study demonstrates the feasibility of this schedule in a multicenter setting. The oncologic results appear similar to those obtained by other accelerated regimens, while the rate of late complications seems acceptable. Five-week accelerated regimens warrant further evaluation, particularly in conjunction with concomitant chemotherapy, in the framework of prospective trials. (orig.) [de

Perception and processing of information relevant to critical incidents and emergencies; Wahrnehmung und Verarbeitung stoer- und unfallrelevanter Informationen

Energy Technology Data Exchange (ETDEWEB)

Dombrowsky, W.R. [Kiel Univ. (Germany). Katastrophenforschungsstelle

1997-12-31

Based on the results of empirical research, which implemented and evaluated information to the public requested by law (HIO-Paragraph-11a) and based on the general findings of crisis- and risk-communication research, some disturbing elements in the relationship between entrepreneurs, administration and the public will be described in terms of cognitive dissonance, prejudice, fears and false expectations. The empirical example of public information in emergencies will evidence the conflicting views on types, styles, size and profoundity of such information as well as the differences in perception, motivation and interest of all parties involved. Finally, the cultural context of risk perception and of coping capabilities will be interrelated with historical changes of risk-management to prepare for the understanding that risk- and crisis communication has to be more than talking about safety. (orig.) [Deutsch] Am Beispiel einer Implementations- und Evaluationsforschung zur Erstellung von Stoerfallinformationen nach Paragraph 11a BimSchG fuer zwei Unternehmen und auf Basis des Kenntnisstandes der internationalen Forschung zur Krisen- und Risikokommunikation wird verdeutlicht, welche kognitiven Dissonanzen zwischen Anlagenbetreibern, Behoerden und Bevoelkerung ueber Art, Umfang und Gestaltung von Gefahrinformationen bestehen, welche Vorurteile und Aengste eine sachliche Kommunikation behindern, welche gesellschaftlichen Faktoren bislang weitgehend uebersehen wurden, was von wem fuer `stoer- und unfallrelevant` gehalten wird und welche gesellschaftlichen, sozialen `settings`, d.h. welche menschlichen Bedingungen die Wahrnehmung und Verarbeitung welcher Informationen beeinflussen. Darin liegt die empirische Bestaetigung der Hypothese, dass sich die Wahrnehmung von Risiken und Bedrohungen historisch kurzfristig (bereits innerhalb einer Generation) veraendert und es keine `one-for-all`-Strategie der Risiko- und Krisenkommunikation geben kann, wohl aber allgemeine

Bewegung bei Vorschulkindern: Empfehlungen und Wirklichkeit

Directory of Open Access Journals (Sweden)

Graf C

2011-01-01

Full Text Available Bewegung und körperliche Aktivität spielen insbesondere in der ganzheitlichen Entwicklung von Kindern eine wichtige Rolle. Heutzutage ist der kindliche Lebensstil allerdings von Bewegungsarmut und der Nutzung audiovisueller Medien geprägt. Bereits Kindergartenkinder sind überwiegend inaktiv bzw. verbringen viel Zeit mit Fernsehen. Eine mögliche Folge von mangelnder Bewegung können motorische Defizite darstellen. In eigenen Kollektiven schneiden mindestens 45 % der Kinder unterdurchschnittlich in den motorischen Hauptbeanspruchungsformen Koordination, Kraft und Schnelligkeit ab. Inwiefern sich dies langfristig auf die gesunde körperliche, aber auch geistige und emotionale Entwicklung der Kinder auswirkt, kann derzeit noch nicht beantwortet werden. Sicherlich unterstützen aber motorische Defizite ein Meidungsverhalten und den weiteren Rückzug aus der Bewegung sowie die Entwicklung von Übergewicht und Adipositas. Allgemein wird für Kinder in dieser Altersgruppe mindestens 2 Stunden tägliche Bewegungszeit sowie eine Reduktion der Fernsehzeit auf maximal 30 Min. empfohlen. Um diese Ziele zu erreichen bzw. zu unterstützen, sind effektive präventive Programme in den verschiedenen Lebensräumen der Kinder, Kindergärten, aber auch pädiatrischen Praxen etc. vonnöten. Bislang ist kein gesundheitsförderlicher/ präventiver „Königsweg“ bekannt, insbesondere nicht für Risikofamilien mit einem geringen sozioökonomischen Status und/oder Migrationshintergrund. Wichtig erscheinen aber die Förderung der intersektoralen Zusammenarbeit und ein Schwerpunkt in der Planung und Umsetzung auf Qualitätssicherung und Projektmanagement, um auch nachhaltig die Gesundheit der Kinder zu unterstützen.

Selective extraction of U(VI), Th(IV), and La(III) from acidic matrix solutions and environmental samples using chemically modified Amberlite XAD-16 resin

Energy Technology Data Exchange (ETDEWEB)

Prabhakaran, D.; Subramanian, M.S. [Department of Chemistry, Indian Institute of Technology, 600 036, Chennai (India)

2004-06-01

A new grafted polymer has been developed by the chemical modification of Amberlite XAD-16 (AXAD-16) polymeric matrix with [(2-dihydroxyarsinoylphenylamino)methyl]phosphonic acid (AXAD-16-AsP). The modified polymer was characterized by a combination of {sup 13}C CPMAS and {sup 31}P solid-state NMR, Fourier transform-NIR-FIR-Raman spectroscopy, CHNPS elemental analysis, and thermogravimetric analysis (TGA). The distribution studies for the extraction of U(VI), Th(IV), and La(III) from acidic solutions were performed using an AXAD-16-AsP-packed chromatographic column. The influences of various physiochemical parameters on analyte recovery were optimized by both static and dynamic methods. Accordingly, even under high acidities (>4 M), good distribution ratio (D) values (10{sup 2}-10{sup 4}) were achieved for all the analytes. Metal ion desorption was effective using 1 mol L{sup -1} (NH{sub 4}){sub 2}CO{sub 3}. From kinetic studies, a time duration of <15 min was sufficient for complete metal ion saturation of the resin phase. The maximum metal sorption capacities were found to be 0.25, 0.13, and 1.49 mmol g{sup -1} for U(VI); 0.47, 0.39, and 1.40 mmol g{sup -1} for Th(IV); and 1.44, 1.48, and 1.12 mmol g{sup -1} for La(III), in the presence of 2 mol L{sup -1} HNO{sub 3}, 2 mol L{sup -1} HCl, and under pH conditions, respectively. The analyte selectivity of the grafted polymer was tested in terms of interfering species tolerance studies. The system showed an enrichment factor of 365, 300, and 270 for U(VI), Th(IV), and La(III), and the limit of analyte detection was in the range of 18-23 ng mL{sup -1}. The practical applicability of the polymer was tested with synthetic nuclear spent fuel and seawater mixtures, natural water, and geological samples. The RSD of the total analytical procedure was within 4.9%, thus confirming the reliability of the developed method. (orig.)

[Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung : Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen. Stadt, Land und Konfession 1500-1721. Teil 1.] / Jürgen Beyer

Index Scriptorium Estoniae

Beyer, Jürgen, 1965-

2010-01-01

Arvustus: Die baltischen Lande im Zeitalter der Reformation und Konfessionalisierung. Livland, Estland, Ösel, Ingermanland, Kurland und Lettgallen. Stadt, Land und Konfession 1500-1721. Teil 1. (Münster : Aschendorff, 2009)

Predictors of Local Recurrence After Rituximab-Based Chemotherapy Alone in Stage III and IV Diffuse Large B-Cell Lymphoma: Guiding Decisions for Consolidative Radiation

Energy Technology Data Exchange (ETDEWEB)

Jegadeesh, Naresh; Rajpara, Raj; Esiashvili, Natia; Shi, Zheng [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Liu, Yuan [Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Department of Biostatistics and Bioinformatics Shared Resource, Emory University, Atlanta, Georgia (United States); Okwan-Duodu, Derrick [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Flowers, Christopher R. [Winship Cancer Institute, Emory University, Atlanta, Georgia (United States); Department of Medical Oncology, Emory University, Atlanta, Georgia (United States); Khan, Mohammad K., E-mail: drkhurram2000@gmail.com [Department of Radiation Oncology, Emory University, Atlanta, Georgia (United States); Winship Cancer Institute, Emory University, Atlanta, Georgia (United States)

2015-05-01

Purpose: The role of consolidative radiation therapy (RT) for stage III and IV diffuse large B-cell lymphoma (DLBCL) in the era of rituximab is not well defined. There is evidence that some patients with bulky disease may benefit, but patient selection criteria are not well established. We sought to identify a subset of patients who experienced a high local failure rate after receiving rituximab-based chemotherapy alone and hence may benefit from the addition of consolidative RT. Methods and Materials: Two hundred eleven patients with stage III and IV DLBCL treated between August 1999 and January 2012 were reviewed. Of these, 89 had a complete response to systemic therapy including rituximab and received no initial RT. Kaplan-Meier analysis and Cox proportional hazards regression were performed, with local recurrence (LR) as the primary outcome. Results: The median follow-up time was 43.9 months. Fifty percent of patients experienced LR at 5 years. In multivariate analysis, tumor ≥5 cm and stage III disease were associated with increased risk of LR. The 5-year LR-free survival was 47.4% for patients with ≥5-cm lesions versus 74.7% for patients with <5-cm lesions (P=.01). In patients with <5-cm tumors, the maximum standardized uptake value (SUVmax) was ≥15 in all patients with LR. The 5-year LR-free survival was 100% in SUV<15 versus 68.8% in SUV≥15 (P=.10). Conclusions: Advanced-stage DLBCL patients with stage III disease or with disease ≥5 cm appear to be at an increased risk for LR. Patients with <5-cm disease and SUVmax ≥15 may be at higher risk for LR. These patients may benefit from consolidative RT after chemoimmunotherapy.

Predictors of Local Recurrence After Rituximab-Based Chemotherapy Alone in Stage III and IV Diffuse Large B-Cell Lymphoma: Guiding Decisions for Consolidative Radiation

International Nuclear Information System (INIS)

Jegadeesh, Naresh; Rajpara, Raj; Esiashvili, Natia; Shi, Zheng; Liu, Yuan; Okwan-Duodu, Derrick; Flowers, Christopher R.; Khan, Mohammad K.

2015-01-01

Purpose: The role of consolidative radiation therapy (RT) for stage III and IV diffuse large B-cell lymphoma (DLBCL) in the era of rituximab is not well defined. There is evidence that some patients with bulky disease may benefit, but patient selection criteria are not well established. We sought to identify a subset of patients who experienced a high local failure rate after receiving rituximab-based chemotherapy alone and hence may benefit from the addition of consolidative RT. Methods and Materials: Two hundred eleven patients with stage III and IV DLBCL treated between August 1999 and January 2012 were reviewed. Of these, 89 had a complete response to systemic therapy including rituximab and received no initial RT. Kaplan-Meier analysis and Cox proportional hazards regression were performed, with local recurrence (LR) as the primary outcome. Results: The median follow-up time was 43.9 months. Fifty percent of patients experienced LR at 5 years. In multivariate analysis, tumor ≥5 cm and stage III disease were associated with increased risk of LR. The 5-year LR-free survival was 47.4% for patients with ≥5-cm lesions versus 74.7% for patients with <5-cm lesions (P=.01). In patients with <5-cm tumors, the maximum standardized uptake value (SUVmax) was ≥15 in all patients with LR. The 5-year LR-free survival was 100% in SUV<15 versus 68.8% in SUV≥15 (P=.10). Conclusions: Advanced-stage DLBCL patients with stage III disease or with disease ≥5 cm appear to be at an increased risk for LR. Patients with <5-cm disease and SUVmax ≥15 may be at higher risk for LR. These patients may benefit from consolidative RT after chemoimmunotherapy

Displacement of the hip center of rotation after arthroplasty of Crowe III and IV dysplasia: a radiological and biomechanical study.

Science.gov (United States)

Abolghasemian, Mansour; Samiezadeh, Saeid; Jafari, Davood; Bougherara, Habiba; Gross, Allan E; Ghazavi, Mohammad T

2013-06-01

To study the direction and biomechanical consequences of hip center of rotation (HCOR) migration in Crowe type III and VI hips after total hip arthroplasty, post-operative radiographs and CT scans of several unilaterally affected hips were evaluated. Using a three-dimensional model of the human hip, the HCOR was moved in all directions, and joint reaction force (JRF) and abductor muscle force (AMF) were calculated for single-leg stance configuration. Comparing to the normal side, HCOR had displaced medially and inferiorly by an average of 23.4% and 20.8%, respectively, of the normal femoral head diameter. Significant decreases in JRF (13%) and AMF (46.13%) were observed in a presumptive case with that amount of displacement. Isolated inferior displacement had a small, increasing effect on these forces. In Crowe type III and IV hips, the HCOR migrates inferiorly and medially after THA, resulting in a decrease in JRF, AMF, and abductor muscle contraction force. Copyright © 2013 Elsevier Inc. All rights reserved.

Stage III & IV colon and rectal cancers share a similar genetic profile: a review of the Oregon Colorectal Cancer Registry.

Science.gov (United States)

Gawlick, Ute; Lu, Kim C; Douthit, Miriam A; Diggs, Brian S; Schuff, Kathryn G; Herzig, Daniel O; Tsikitis, Vassiliki L

2013-05-01

Determining the molecular profile of colon and rectal cancers offers the possibility of personalized cancer treatment. The purpose of this study was to determine whether known genetic mutations associated with colorectal carcinogenesis differ between colon and rectal cancers and whether they are associated with survival. The Oregon Colorectal Cancer Registry is a prospectively maintained, institutional review board-approved tissue repository with associated demographic and clinical information. The registry was queried for any patient with molecular analysis paired with clinical data. Patient demographics, tumor characteristics, microsatellite instability status, and mutational analysis for p53, AKT, BRAF, KRAS, MET, NRAS, and PIK3CA were analyzed. Categorical variables were compared using chi-square tests. Continuous variables between groups were analyzed using Mann-Whitney U tests. Kaplan-Meier analysis was used for survival studies. Comparisons of survival were made using log-rank tests. The registry included 370 patients: 69% with colon cancer and 31% with rectal cancer. Eighty percent of colon cancers and 68% of rectal cancers were stages III and IV. Mutational analysis found no significant differences in detected mutations between colon and rectal cancers, except that there were significantly more BRAF mutations in colon cancers compared with rectal cancers (10% vs 0%, P colon versus rectal cancers when stratified by the presence of KRAS, PIK3CA, and BRAF mutations. Stage III and IV colon and rectal cancers share similar molecular profiles, except that there were significantly more BRAF mutations in colon cancers compared with rectal cancers. Copyright © 2013 Elsevier Inc. All rights reserved.

Uranium (III)-Plutonium (III) co-precipitation in molten chloride

Science.gov (United States)

Vigier, Jean-François; Laplace, Annabelle; Renard, Catherine; Miguirditchian, Manuel; Abraham, Francis

2018-02-01

Co-management of the actinides in an integrated closed fuel cycle by a pyrochemical process is studied at the laboratory scale in France in the CEA-ATALANTE facility. In this context the co-precipitation of U(III) and Pu(III) by wet argon sparging in LiCl-CaCl2 (30-70 mol%) molten salt at 705 °C is studied. Pu(III) is prepared in situ in the molten salt by carbochlorination of PuO2 and U(III) is then introduced as UCl3 after chlorine purge by argon to avoid any oxidation of uranium up to U(VI) by Cl2. The oxide conversion yield through wet argon sparging is quantitative. However, the preferential oxidation of U(III) in comparison to Pu(III) is responsible for a successive conversion of the two actinides, giving a mixture of UO2 and PuO2 oxides. Surprisingly, the conversion of sole Pu(III) in the same conditions leads to a mixture of PuO2 and PuOCl, characteristic of a partial oxidation of Pu(III) to Pu(IV). This is in contrast with coconversion of U(III)-Pu(III) mixtures but in agreement with the conversion of Ce(III).

Polypyrrole–titanium(IV) doped iron(III) oxide nanocomposites: Synthesis, characterization with tunable electrical and electrochemical properties

International Nuclear Information System (INIS)

Nandi, Debabrata; Ghosh, Arup Kumar; Gupta, Kaushik; De, Amitabha; Sen, Pintu; Duttachowdhury, Ankan; Ghosh, Uday Chand

2012-01-01

Highlights: ► Synthesis and characterization of polymer nanocomposite based on titanium doped iron(III) oxide. ► Electrical conductivity increased 100 times in composite with respect to polymer. ► Electrochemical capacitance of polymer composites increased with nanooxide content. ► Thermal stability of the polymer enhanced with nano oxide content. -- Abstract: Titanium(IV)-doped synthetic nanostructured iron(III) oxide (NITO) and polypyrrole (PPy) nanocomposites was fabricated by in situ polymerization using FeCl 3 as initiator. The polymer nanocomposites (PNCs) and pure NITO were characterized by X-ray diffraction, Föurier transform infrared spectroscopy, scanning electron microscopy, electron dispersive X-ray spectroscopy, transmission electron microscopy, etc. Thermo gravimetric and differential thermal analyses showed the enhancement of thermal stability of PNCs than the pure polymer. Electrical conductivity of the PNCs had increased significantly from 0.793 × 10 −2 S/cm to 0.450 S/cm with respect to the PPy, and that had been explained by 3-dimensional variable range hopping (VRH) conduction mechanisms. In addition, the specific capacitance of PNCs had increased from 147 F/g to 176 F/g with increasing NITO content than that of pure NITO (26 F/g), presumably due to the growing of mesoporous structure with increasing NITO content in PNCs which reduced the charge transfer resistance significantly.

Bakteriochlorophyllvorstufen und Pigment-Protein-Komplexe in Rhodospirillum rubrum ST3 und GN11

OpenAIRE

Hammel, Jörg U.

2006-01-01

In der vorliegenden Arbeit wurden zwei Mutanten des Alpha-Proteobakteriums Rhodospirillum rubrum untersucht, die im Bakteriochlorophyll-Biosyntheseweg unterbrochen sind, um einen Beitrag zum genaueren Verständnis der Biosynthese dieser Moleküle und der einzelnen daran beteiligten Schritte zu liefern. Von den beiden Stämmen ST3 und GN11 wurden die ins Kulturmedium ausgeschiedenen Pigmente aufgereinigt und spektroskopisch analysiert. Ebenfalls wurden sowohl von ST3, als auch von GN11 die in int...

Blogs und Journalismus – Konkurrenz oder Ergänzung? – Das Verhältnis von Blogs und Journalismus in Deutschland

Directory of Open Access Journals (Sweden)

Saskia Leidinger

2015-12-01

Full Text Available Mit der Frage, ob „Blogs und Journalismus - Konkurrenz oder Ergänzung“ sind, beschäftigt sich Saskia Leidinger in dem gleichnamigen Essay über „das Verhältnis von Blogs und Journalismus in Deutschland“. In vergleichender Perspektive richtet die Autorin ihr Hauptaugenmerk auf die Arbeitsweise sowie die Eigen- und Fremdwahrnehmung von Bloggern und Journalisten, um Gemeinsamkeiten und Unterschiede herauszustellen und ihre je spezifische Funktion innerhalb der der heutigen Informationsgesellschaft einzugrenzen.

›All for nothing?‹. Die symbolische Darstellungs- und Erkenntnisform als philosophische und literaturtheoretische Herausforderung

Directory of Open Access Journals (Sweden)

Falk Bornmüller

2013-05-01

Full Text Available Literaturwissenschaft und Philosophie sehen sich gleichermaßen mit der Frage konfrontiert, wie mit dem Erkenntnismedium Literatur umgegangen und wie es in das eigene Erkenntnisinteresse integriert werden kann. Dabei ist das epistemologische Verhältnis von Literatur und Philosophie nicht etwa als ein streng dichotomisches zu verstehen, das sich auf die Formel propositional vs. nicht-propositional reduzieren lässt. Vielmehr ist ein erkenntnistheoretischer Gehalt von Literatur anzunehmen, dem eine binäre Betrachtungsweise nicht gerecht wird. Anhand zentraler Stellen in Shakespeares »Hamlet« und Goethes »Wilhelm Meisters Lehrjahre« wird die »symbolische Darstellungs- und Erkenntnisform« der Literatur als ein Akt der Erkenntnis, als ein nachvollziehendes Verstehen herausgearbeitet.

Lessing und der Islam

OpenAIRE

Muslim, Zahim Mohammed

2010-01-01

„Lessing und der Islam“ beschäftigt sich unparteiisch mit Lessings Auseinandersetzung mit dem Islam. Die Arbeit setzt sich das Ziel, den Leser und den Literaturkennern sowie der deutschen Bibliothek der Germanistik etwas von Lessings Auseinandersetzung mit dem Islam in die Hand zu geben, die bis heute als großes Modell für die interkulturelle und interreligiöse Menschheitstoleranzdebatte im Gedächtnis der deutschen Literatur vorhanden ist. Im ersten Teil widmet sich die vorliegende Arbeit de...

[Christofer Herrmann. Kloster und Burg - die architektur des Deutschens Ordens im Pressen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik] / Dennis Hortmuth

Index Scriptorium Estoniae

Hortmuth, Dennis

2011-01-01

Arvustus: Christofer Herrmann. Kloster und Burg - die Architektur des Deutschen Ordens in Preussen und Livland. In : Glaube, Macht und Pracht. GeistlicheGemeinschaften des Ostseeraums im Zeitalter der Backsteingotik (=Archäologie und Geschichte im Ostseeraum; Archaeology and History of the Baltic 6) Rahden : Verlag Marie Leidorf, 2009. S. 209-219. Saksa Ordu arhitektuurist Preisi- ja Liivimaal

Selective liquid-liquid extraction of antimony(III from hydrochloric acid media by N-n-octylaniline in xylene

Directory of Open Access Journals (Sweden)

M. A. ANUSE

2004-04-01

Full Text Available N-n-Octylaniline in xylene was used for the extraction separation of antimony(III from hydrochloric acid media. Antimony(III was extracted quantitatively with 10 mL 4 % N-n-octylaniline in xylene. It was stripped from the organic phase with 0.5 M ammonia and estimated photometrically by the iodide method. The effect of metal ion, acid, reagent concentration and various foreign ions was investigated. The method affords binary and ternary separation of antimony(III from tellurium(IV, selenium(IV, lead(II, bismuth(III, tin(IV, germanium(IV, copper(II, gold(III, iron(III and zinc(II. The method is applicable for the analysis of synthetic mixtures, alloys and semiconductor thin films. It is fast, accurate and precise.

Erwachsenenbildung und Medienpädagogik: LinkedIn & Lynda, XING und Google als Bildungsanbieter

Directory of Open Access Journals (Sweden)

Anke Grotlüschen

2018-03-01

Full Text Available Eine der grossen Systematiken der Erwachsenenbildung ist die Unterscheidung in didaktische Handlungsebenen (Mikro-, Meso- und Makroebene, (Schmidt-Lauff 2012, mit Blick auf Internationalisierung und Globalisierung ergänzt um die Mega-Ebene (Egetenmeyer et al. 2017. Diese setzen auf Tietgens didaktischen Handlungsebenen auf. Digitale Möglichkeiten für die Erwachsenenbildung (von Augmented Reality bis Webinar, werden hier in systematisierender Absicht in den didaktischen Handlungsebenen verortet. Dadurch wird erkennbar, dass die Aufgabe der Erwachsenenbildung immer auch die Problematisierung und begründete Entscheidung didaktischer Arrangements enthält. Ein zentraler Aspekt lässt sich jedoch eher schlecht in das klassische Modell einfügen: Die Frage der personalisierten Werbung und der Nutzung bildungsrelevanter Kundendaten wie Lebensläufe und Stellenbörsen. Genau dies machen sich Unternehmen der Digitalwirtschaft (XING, Google, LinkedIn derzeit zunutze, um Zutritt zum Weiterbildungsmarkt zu erlangen. Entlang dreier Fallanalysen wird versucht – bei begrenztem Zugriff auf Betriebsgeheimnisse – eine vorsichtige Einschätzung zu geben, ob es sich hierbei um eine disruptive Entwicklung handelt.

[Glanz und Elend - Mythos und Wirklichkeit der Herrenhäuser im Baltikum] / Karsten Brüggemann

Index Scriptorium Estoniae

Brüggemann, Karsten, 1965-

2014-01-01

Arvustus: Glanz und Elend - Mythos und Wirklichkeit der Herrenhäuser im Baltikum. Hrsg. von Ilse von zur Mühlen im Auftrag der Carl-Schirren-Gesellschaft e.V. und des Ostpreußischen Landesmuseums Lüneburg. Kunstverlag Josef Fink. Lindenberg im Allgäu 2012

Mutual solubility between hexane and three-n-butyl phosphate solvates of lanthanide(III) and thorium(IV) nitrates at various temperatures

International Nuclear Information System (INIS)

Keskinov, V.A.; Lishuk, V.V.; Pyartman, A.K.

2007-01-01

Phase diagrams of binary liquid systems of hexane-rare earth(III) nitrates solvates (rare earth - neodymium, gadolinium, yttrium, ytterbium, lutetium) and thorium(IV) with tri-n-butylphosphate are studied at different temperatures. Phase diagrams of binary systems consist of fields of homogeneous solutions and field of stratification into two liquid phases (I, II): phase I is enriched by hexane, and phase II - [Ln(NO 3 ) 3 (TBP) 3 ] (Ln=Nd, Gd, Y, Yb and Lu) or [Th(NO 3 ) 4 (TBP) 2 ]. Field of stratification into two liquid phases are decreased with growing temperature in binary systems [ru

Emotion, Motivation und Volition

OpenAIRE

Ulich, Dieter

1996-01-01

Emotion, Motivation und Volition / D. Ulich ; V. Brandstätter ; P. M. Gollwitzer. - In: Psychologie / hrsg. von Dietrich Dörner ... - 2., überarb. und erw. Aufl. - Stuttgart u.a. : Kohlhammer, 1996. - S. 115-135

Der Einfluss von sozialer Ungleichheit und kulturellen Unterschieden auf die Wahrnehmung von finanziellen und Arbeitsplatzrisiken: Überlegungen zur Risikogesellschaft

OpenAIRE

Abbott, David; Quilgars, Deborah; Jones, Anwen

2006-01-01

Der vorliegende Artikel beruht auf Daten einer Studie, die sich mit der Frage beschäftigt, wie verschiedene soziale und kulturelle Gruppen die Risiken von Einkommens- und Arbeitsplatzverlust wahrnehmen und darauf reagieren. Autoren wie LASH, DOUGLAS und LUPTON betonten die Bedeutung von Gruppenzugehörigkeit und sozialen Kategorien für die Strukturierung der Reaktionsweisen auf verschiedene Risikoarten. Sie sprechen daher lieber von Risikokulturen als von der Risikogesellschaft. Trotzdem erken...

Bases biológicas para la evaluación y manejo de metapoblaciones de loco en la III y IV Regiones

OpenAIRE

González, J.; Tapia, C.; Wilson, A.; Stotz, W.; Orensanz, J.M.; Parma, A.M.; Valero, J.; Catrilao, M.; Garrido, J.

2005-01-01

En la III y IV Regiones las áreas de manejo y explotación de recursos bentónicos (AMERB) se han establecido como la principal herramienta de manejo del recurso loco (Concholepas concholepas). Sin embargo, su aplicabilidad para la administración y aporte en términos del desarrollo sustentable, aunque sugerentes, requieren de una evaluación objetiva, en cuanto al manejo de carácter discreto que se ha establecido para cada AMERB, desconociendo la eventual interacción espacial de las mismas. En e...

A simple thermometric technique for reaction-rate determination of inorganic species, based on the iodide-catalysed cerium(IV)-arsenic(III) reaction.

Science.gov (United States)

Grases, F; Forteza, R; March, J G; Cerda, V

1985-02-01

A very simple reaction-rate thermometric technique is used for determination of iodide (5-20 ng ml ), based on its catalytic action on the cerium(IV)-arsenic(III) reaction, and for determination of mercury(II) (1.5-10 ng ml ) and silver(I) (2-10 ng ml ), based on their inhibitory effect on this reaction. The reaction is followed by measuring the rate of temperature increase. The method suffers from very few interferences and is applied to determination of iodide in biological and inorganic samples, and Hg(II) and Ag(I) in pharmaceutical products.

Calibration and characterisation of solar cells: Comparison of pulsed and steady-state simulation of sunlight; Kalibrierung und Charakterisierung von Solarzellen: Vergleich von gepulster und stationaerer Sonnensimulation

Energy Technology Data Exchange (ETDEWEB)

Metzdorf, J; Kessler, F R; Bentlage, V; Holstenberg, H C; Sperling, A; Winter, S; Wittchen, T

1995-03-01

Pulsed solar simulators are widely used for the secondary calibration of photovoltaic modules against reference solar cells, because the uniformity and spectral match requirements for large-area class A or B simulators can be met more easily and economically by pulsed than by steady-state simulators. Moreover, a pulsed simulator produces little additional heat that could increase the temperature of the PV device during the measurement. However, the transient measurement of current-voltage characteristics during a single flash in the ms range often induce distortions or hysteresis effects especially in high-efficiency or high-resistivity silicon solar cells. The sweep-rate distortions have systematically been studied, revealed and simulated by computation as a function of cell technology and measurement conditions. Based on this fundamental analysis, the distortions that have been found to be unavoidable can both be explained and fully be corrected. A simple correction procedure including two auxiliary characteristics measurements in the dark has been developed for the transformation of the distorted IV-curve into the undistorted characteristics. Moreover, detailed improvements in the calibration of reference solar cells have been carried out and prototypes of large-area reference cells have been developed. New as well as developed transient and steady-state laboratory methods for the optoelectronic characterization of solar cells have been tested which can be used to study impurity effects where non-destructive and spatially resolved techniques were the main topic of interest. (orig.) [Deutsch] Fuer die sekundaere Kalibrierung von Photovoltaischen Modulen im Vergleich mit Referenzsolarzellen werden ueberwiegend gepulste Sonnensimulatoren eingesetzt, mit denen die Forderungen nach Homogenitaet und spektraler Anpassung an ein Referenz-Sonnenspektrum zugleich ohne Erwaermung des Moduls gut erfuellt werden koennen. Grossflaechige Strahlungsfelder der gleichen Qualitaet

Superman = Persepolis = Naruto? Herausforderungen und Probleme der formalen und inhaltlichen Vielfalt von Comics und Comicforschung für die Regensburger Verbundklassifikation

Directory of Open Access Journals (Sweden)

Michael Franke-Maier

2016-12-01

Full Text Available Das populäre Medium Comic hat in den vergangenen Jahren zunehmend Interesse als wissenschaftliches Forschungsobjekt und damit auch als bibliothekarisches Sammlungsgut auf sich gezogen. Bibliotheken stehen vor der Aufgabe, die Primärquellen und vor allem die wissenschaftliche Forschungsliteratur zu Comics inhaltlich zu erschließen und nach wie vor auch systematisch zu präsentieren. Bis vor kurzem fand man in der in Deutschland am weitesten verbreiteten Klassifikation, der im Selbstverständnis wissenschaftsnahen Regensburger Verbundklassifikation, nur Einzelstellen in einzelnen Fachsystematiken und einen größeren Bereich in der Japanologie für das Phänomen Manga. Dieser Zustand war nicht ausreichend für eine differenzierte Aufstellung in Bibliotheken mit entsprechenden Beständen und Schwerpunkten. Der hier präsentierte RVK-Baum für Comics und Comicforschung wird diesem Desiderat gerecht und bietet eine Möglichkeit, Comicbestände adäquat klassifikatorisch abzubilden.   In recent years the popular medium of comics has attracted increasing research interest and, consequently, comics have been recognized as objects for collection in libraries. Libraries face the task of classifying the primary sources and especially the scientific research literature on comics in order to present them systematically. Until recently, the most widely used academic library classification in Germany, the Regensburg Classification (RVK, provided only individual notations in some subject classifications and, additionally, a larger area on manga in the Japanese studies section. This situation was not sufficient for a differentiated shelving, or, respectively, classifying in libraries with correspondent resources and priorities. The paper presents a tree of RVK-notations for comics and comic research, which satisfies the desiderata and provides a way to map comic collections adequately to a classificatory scheme

An isoelectronic NO dioxygenase reaction using a nonheme iron(III)-peroxo complex and nitrosonium ion.

Science.gov (United States)

Yokoyama, Atsutoshi; Han, Jung Eun; Karlin, Kenneth D; Nam, Wonwoo

2014-02-18

Reaction of a nonheme iron(III)-peroxo complex, [Fe(III)(14-TMC)(O2)](+), with NO(+), a transformation which is essentially isoelectronic with that for nitric oxide dioxygenases [Fe(III)(O2˙(-)) + NO], affords an iron(IV)-oxo complex, [Fe(IV)(14-TMC)(O)](2+), and nitrogen dioxide (NO2), followed by conversion to an iron(III)-nitrato complex, [Fe(III)(14-TMC)(NO3)(F)](+).

Enterprise Portals und Enterprise Application Integration - Begriffsbestimmung und Integrationskonzeptionen

OpenAIRE

Schelp, Joachim; Winter, Robert

2002-01-01

Unter den Stichworten »Enterprise Portals« und »Enterprise Application Integration« werden neue Herausforderungen an die Applikationsarchitektur der Unternehmungen gestellt. Bei beiden spielt die Integration vorhandener und das Einfügen neuer Applikationen eine große Rolle. Beiden Themen ist gemein, dass sie die Diskussion bestimmter technischer Konzepte aus den vergangenen Jahren fortsetzen: Portale stellen das moderne Frontend dar, über das die verschiedenen E-Business-Konzepte umgesetzt we...

Restaurierung von Seen und Renaturierung von Seeufern

Science.gov (United States)

Grüneberg, Björn; Ostendorp, Wolfgang; Leßmann, Dieter; Wauer, Gerlinde; Nixdorf, Brigitte

Süßwasserseen haben als ökosysteme und Lebensraum für Pflanzen und Tiere eine herausragende Bedeutung für die Artenvielfalt auf der Erde und prägen als Landschaftselemente unsere natürliche Umwelt. Seen fungieren als natürliche Stoffsenken, vor allem für Kohlenstoff und Nährstoffe, aber auch als Senken für in ihren Einzugsgebieten emittierte gelöste und feste Schadstoffe. Darüber hinaus ist Wasser eine wichtige Naturressource. Süßwasserseen stellen in den meisten Regionen der Erde lebenswichtige Quellen für die Versorgung mit Trinkwasser und tierischem Eiweiß (Fischfang) dar. Sie dienen als Wasserspeicher für die landwirtschaftliche und industrielle Nutzung. Auch für Erholungsaktivitäten des Menschen kommt ihnen eine große Bedeutung zu.

Gosvig und das Problem der Geschichte

DEFF Research Database (Denmark)

Wentzer, Thomas Schwarz

2016-01-01

Der Essay geht der Frage nach, wieso so viele philosophische Bücher, insbesondere innerhalb der sogenannten 'kontinentalen' Philosophie des 20. Jhs, einen Titel tragen, der durch die Struktur 'x und y' gekennzeichnet ist. Hat Heideggers 'Sein und Zeit' auch hier Schule gemacht? Wenn ja, wie so? U...... These, dass die Iteration des 'und' tatsächlich und in Kontrast zur Genetivkonstruktion der Idealisten ('Phänomenologie des Geistes') die Geschichtlichkeit im Zeitalter postsubjektivistischen Denkens reflektiert....

Die Landschaft in der Geschichte, in der Kultur, in der Kunts und in der Stadtplanung: theoretische Annahmen und Erfahrungen

Directory of Open Access Journals (Sweden)

Mario Coletta

2013-01-01

Full Text Available Das vorgeschlagene Thema hat das Ziel, dem Konzept der Landschaft eine neue Definition zu geben. Sie soll nicht nur als Umhuellung des staedtischen und laendlichen Territoriums gesehen werden, das besiedelt und produktiv ist, zivilisiet und natuerlich belassen, sondern wie ein lebender Koerper, wenn auch nicht bei bester Gesundheit, der trotz seines Altes noch den vielen Veraenderungen standhaelt. Veraenderungen durch Naturkatatrophen herforgerufen, und besonders durch die vielen Wunden die das Werk der Menschen ihm zugefuegt hat. Als lebendes Wesen leidet die Landschaft und freut sich in guten Zeiten, kleidert sich lieber arm, aber schicklich, als reich und anmassend: Zeuge guter und schlechter Haushaltsfuehrung, jedoch Erbe einer Geschichte die sie erhebt, die Geschichte, Literatur, Ausdruecke der Kunts, kreative Planung beseelt hat. All das ist zusammengefasst in dem Wort "Kultur", die es verdient hat, erworben zu werden, vertieft und den naeschsten Generationen weitergegeben, moeglicherweise noch bereichert von dem, das die heutige Kultur ausarbeiten kann, auch auf dem Weg der Stadtplanung.

Digitalisierung und Selbstbestimmung

Directory of Open Access Journals (Sweden)

Eisenberger, Iris

2017-12-01

Full Text Available Kurztext: Der Beitrag beleuchtet das Verhältnis von Digitalisierung und Recht. Am Beispiel der Blockchain-Technologie wird aufgezeigt, wie neue Formen und Räume der Selbstbestimmung geschaffen werden können. In distribuierten Systemen ist die Tendenz erkennbar, dass sich die rechtliche hin zu einer technologischen Steuerung verlagert. Wenn Funktionen, die für gewöhnlich der demokratisch legitimierte Gesetzgeber wahrnimmt, auf andere Systeme übergehen, führt dies zu Herausforderungen für rechtsstaatliche Demokratien. Fundamentale Fragen von Kontrolle und Machtbeschränkung iZm Digitalisierung stehen im Fokus. Der Beitrag plädiert schließlich für „legal foresight“-Forschung im Bereich neuer Technologien.

Führung und Machiavellismus

NARCIS (Netherlands)

Belschak, F.D.; den Hartog, D.N.; Felfe, J.

2015-01-01

In diesem Beitrag wird der Zusammenhang zwischen Führung und Machiavellismus aus zwei verschiedenen Perspektiven betrachtet. Zum einen werden neuere Forschungsergebnisse referiert, wie machiavellistische Mitarbeiter auf verschiedene Führungsstile ihres Vorgestzten reagieren und so mit Hinblick auf

Netzformen und VDE-Bestimmungen

Science.gov (United States)

Bernstein, Herbert

Der Verband Deutscher Elektrotechniker (VDE) hat eine Reihe von Vorschriften ausgearbeitet, die dem Schutz von Leben und Sachen beim Umgang mit elektrischer Energie dienen. Besonders wichtig sind die in den VDE-Bestimmungen 0100 und 0411 festgelegten Vorschriften.

Are stage IV vestibular schwannomas preoperatively different from other stages?

Science.gov (United States)

Tringali, Stéphane; Dubreuil, Christian; Zaouche, Sandra; Ferber-Viart, Chantal

2008-01-01

The aim of this study was to focus on the clinical and paraclinical symptoms of patients suffering from Stage IV vestibular schwannomas (VSs). In this prospective study, we included 734 patients who have VS and candidates for operation. Patients were classified as having Stage I, II, III, or IV tumors according to Tos criteria as evaluated by magnetic resonance imaging. PREOPERATIVE CLINICAL EVALUATION: We recorded the occurrence of complaints (%) and duration (yr) of hearing loss, tinnitus, and balance disorder. Preoperative paraclinical evaluation included pure-tone (PTA) and speech audiometry, auditory brainstem response (ABR) patterns, and vestibular deficit at videonystamography (VNG). Continuous variables were compared between Stage IV and other stages using analysis of variance. Qualitative variables expressed as a percentage of presence were compared between Stage IV and other stages using percentage comparison. Quantitative Parameters. Patients with Stage IV VS were significantly younger as compared with patients with other stages. Stage IV hearing loss was greater compared with other stages at 250 and 500 Hz but smaller at 2,000 and 8,000 Hz. We found no difference in the loss of PTA between Stage IV and the other stages. Speech discriminancy score was smaller in Stage IV. The durations of hearing loss, tinnitus, and balance disorders were similar whatever the tumor stage. Auditory brainstem response patterns showed no difference in Wave III latency between Stage IV VS and other stages, whereas Wave V latency and V-I interval were higher in Stage IV. Both ABR threshold and VNG caloric deficit were higher in Stage IV VS compared with other stages. Qualitative Parameters. The percentage of patients with Stage IV was lower than that with Stages II and III. The percentage of men and women was similar in all stages. The occurrence of hearing loss was similar in all stages, whereas that of tinnitus was lower in Stage IV compared with Stages I and II. In

Vergleichende Kraft-Dehnungs- und Dauerlastversuche mit kieferorthopädischen Gummizügen und pseudoelastischen Ni-Ti-Federn

OpenAIRE

Buch, Stefan

2003-01-01

Bei einer Behandlung mit festsitzenden Apparaturen stehen für Zahnverschiebungen in mesio-distaler Richtung und zur Okklusionseinstellung seit 1993 als Alternative zu Gummiringen aus Latex Zugfedern aus der Nickel-Titan-Legierung Sentalloy zur Verfügung. Die vorliegende Untersuchung zeigt die materialtechnischen Besonderheiten der beiden Werkstoffe auf und beschreibt die Vor- und Nachteile in der klinischen Anwendung der Gummizüge und der Federn. Es wurden Gummizüge aus Latex von Ormco Dental...

Bildanalyse in Medizin und Biologie

Science.gov (United States)

Athelogou, Maria; Schönmeyer, Ralf; Schmidt, Günther; Schäpe, Arno; Baatz, Martin; Binnig, Gerd

Heutzutage sind bildgebende Verfahren aus medizinischen Untersuchungen nicht mehr wegzudenken. Diverse Methoden - basierend auf dem Einsatz von Ultraschallwellen, Röntgenstrahlung, Magnetfeldern oder Lichtstrahlen - werden dabei spezifisch eingesetzt und liefern umfangreiches Datenmaterial über den Körper und sein Inneres. Anhand von Mikroskopieaufnahmen aus Biopsien können darüber hinaus Daten über die morphologische Eigenschaften von Körpergeweben gewonnen werden. Aus der Analyse all dieser unterschiedlichen Arten von Informationen und unter Konsultation weiterer klinischer Untersuchungen aus diversen medizinischen Disziplinen kann unter Berücksichtigung von Anamnesedaten ein "Gesamtbild“ des Gesundheitszustands eines Patienten erstellt werden. Durch die Flut der erzeugten Bilddaten kommt der Bildverarbeitung im Allgemeinen und der Bildanalyse im Besonderen eine immer wichtigere Rolle zu. Gerade im Bereich der Diagnoseunterstützung, der Therapieplanung und der bildgeführten Chirurgie bilden sie Schlüsseltechnologien, die den Forschritt nicht nur auf diesen Gebieten maßgeblich vorantreiben.

Rechtspopulistische Einstellungen in Ost- und Westdeutschland

Directory of Open Access Journals (Sweden)

Beate Küpper

2017-12-01

Full Text Available Während sich die Mehrheit der Deutschen für Demokratie, Vielfalt und Gleichwertigkeit positioniert, sind zugleich rechtspopulistische Einstellungen lauter geworden. Der Beitrag berichtet über Befunde der Mitte-Studie der Friedrich-Ebert-Stiftung 2016 zu der Verbreitung rechtspopulistischer und rechtsextreme Einstellungen, wirft einen besonderen Blick auf potentielle Wähler_innen der AfD und diskutiert am Ende mögliche Erklärungen für die gefundenen Unterschiede zwischen Ost- und Westdeutschen.

FISA-2009 Conference on Euratom Research and Training Activities: Nuclear Fission - Past, Present and Future (Generation-II, -III and -IV + Partitioning and Transmutation)

International Nuclear Information System (INIS)

Bhatnagar, V.; Deffrennes, M.; Hugon, M.; Manolatos, P.; Ptackova, K.; Van Goethem, G.; Webster, S.

2011-01-01

This paper is an introduction to the research and training activities carried out under the Euratom 7th Framework Programme (FP7, 2007-2011) in the field of nuclear fission science and technology, covering in particular nuclear systems and safety, and including innovative reactor systems and partitioning and transmutation. It is based on the more than 40 invited lectures that were delivered by Euratom project coordinators and keynote speakers at the FISA-2009 Conference (), organised by the European Commission DG Research, 22-24 June 2009, Prague, Czech Republic. The Euratom programme must be considered in the context of current and future nuclear technology and the respective research effort: ·Generation-II (i.e. yesterday, NPP construction 1970-2000): safety and reliability of nuclear facilities and energy independence in order to ensure security of supply worldwide; ·Generation-III (i.e. today, construction 2000-2040+): continuous improvement of safety and reliability, and increased industrial competitiveness in a growing energy market; ·Generation-IV (i.e. tomorrow, construction from 2040) for increased sustainability though optimal utilisation of natural resources and waste minimisation, and increased proliferation resistance. Consequently, the focus of the lectures devoted to Generation-II and -III is on the major scientific challenges and technological developments needed to guarantee safety and reliability, in particular issues associated with plant lifetime extension and operation. The focus of the lectures devoted to Generation-IV is on the design objectives and associated research issues that have been agreed upon internationally, in particular the ambitious criteria and technology goals established at the international level by the Generation-IV International Forum (GIF). In the future, electricity must continue to be produced competitively, and in addition high temperature process heat may also be required, while exploiting a maximum of fissile and

Entwicklung und Anwendung neuer NMR-Methoden: Orientierungsmedien zur Strukturbestimmung mit anisotropen Parametern und Metabonomics

OpenAIRE

Büchler, Silke

2014-01-01

Das Ziel dieser Arbeit war die Entwicklung und Anwendung neuer Orientierungsmedien zur Strukturbestimmung mit anisotropen Parametern, sowie die Etablierung von Metabonomics-Studien an Flüssigzellkulturen und Reispflanzen.

Sornig, Karl (1993: Sprache: Spiel. (Das agonale Prinzip in der Kommunikation (lrr­ ttimer, Irreführungen, Spiel der Gestalten. Grazer Linguistische Monographien 9. Graz. 416 Seiten.

Directory of Open Access Journals (Sweden)

Stojan Bračič

1995-12-01

Full Text Available Das besprochene Heft 9 aus der Serie "Grazer Linguistische Monographien" ist eigentlich das fünfte Faszikel einer umfangreicheren Studie des Autors, die bis jetzt bereits folgende Themata behandelte: Vom Ur-Schweigen ins Reden (fasc. I, Am­ biguitäten (fasc. II, Metapher (fasc. III, Sprachmagische Strategien (fasc. IV. Im vor­ liegenden fünften Faszikel ist die Rede von lrrtümern (Pannen, Irreführungen und dem Spiel der Gestalten, die alle dem Spiel der Sprache und mit der Sprache zugrunde liegen.

An isoelectronic NO dioxygenase reaction using a nonheme iron(III)-peroxo complex and nitrosonium ion†

Science.gov (United States)

Yokoyama, Atsutoshi; Han, Jung Eun; Karlin, Kenneth D.; Nam, Wonwoo

2014-01-01

Reaction of a nonheme iron(III)-peroxo complex, [FeIII(14-TMC)(O2)]+, with NO+, a transformation which is essentially isoelectronic with that for nitric oxide dioxygenases [Fe(III)(O2•−) + NO], affords an iron(IV)-oxo complex, [FeIV(14-TMC)(O)]2+, and nitrogen dioxide (NO2), followed by conversion to an iron(III)-nitrato complex, [FeIII(14-TMC)(NO3)(F)]+. PMID:24394960

An isoelectronic NO dioxygenase reaction using a nonheme iron(III)-peroxo complex and nitrosonium ion†

OpenAIRE

Yokoyama, Atsutoshi; Han, Jung Eun; Karlin, Kenneth D.; Nam, Wonwoo

2014-01-01

Reaction of a nonheme iron(III)-peroxo complex, [FeIII(14-TMC)(O2)]+, with NO+, a transformation which is essentially isoelectronic with that for nitric oxide dioxygenases [Fe(III)(O2•−) + NO], affords an iron(IV)-oxo complex, [FeIV(14-TMC)(O)]2+, and nitrogen dioxide (NO2), followed by conversion to an iron(III)-nitrato complex, [FeIII(14-TMC)(NO3)(F)]+.

Von Zetteln und Apparaten. Subjektivierung in bundesdeutschen und britischen Arbeitsämtern der 1970er- und 1980er-Jahre

Directory of Open Access Journals (Sweden)

Wiebke Wiede

2016-11-01

Full Text Available The article examines the governance of unemployment by employment offices inthe Federal Republic of Germany and the United Kingdom in the 1970s and 1980s, which were times of persisting mass unemployment in both countries, focusing on social meanings encoded into the social space of employment offices. Applying concepts from actor-network theory, the article investigates the agency of things in the administration of unemployment, e.g. folders of files, queue numbers or vacancy notices. In particular, the article considers the mechanisation and increasing use of machines and IT systems in German and British employment offices. With regard to processes of subjectivisation, it investigates how the unemployed experienced things and objects in employment offices. While the newly designed British Jobcentre offered jobs as part of a self-service concept, the German employment offices remained in the bureaucratic tradition whereby the unemployed primarily waited for employment counselling and placement. Der Beitrag untersucht Arbeitsämter in der Bundesrepublik Deutschland und Großbritannien während der 1970er- und 1980er-Jahre, einer Zeit deutlich gestiegener Arbeitslosenzahlen. Im Fokus stehen die Verwaltungsvorgänge, begriffen als soziale Praktiken und Mensch-Ding-Verhältnisse. Mit der Akteur-Netzwerk-Theorie fragt der Aufsatz nach der Agency der Verwaltungsdinge im Arbeitsamt: den Bürogestaltungen, Aktenordnern, Wartenummern oder Stellenaushängen. Problematisiert wird besonders die in den 1970er- und 1980er-Jahren durchgesetzte Technisierung der administrativen Vorgänge, also der vermehrte Einsatz von Apparaten und EDV-Systemen in bundesdeutschen und britischen Arbeitsverwaltungen. In beiden Ländern wurde »Selbstbedienung« zu einem neuen Verhaltensdispositiv, das sich in den neu eingerichteten britischen Jobcentres jedoch schneller durchsetzte als im traditionellen deutschen Arbeitsamt, wo das passive Warten weiterhin eine vorherrschende

Data Science und Analytics in Bibliotheken

Directory of Open Access Journals (Sweden)

José Luis Preza

2017-09-01

Full Text Available Bibliotheken sind in einer priviligierten Situation: Sie verwalten riesige Mengen von Daten und Informationen. Data Science und Analytics-Methoden ermöglichen es Bibliotheken, den Inhalt, den sie verwalten, voll auszunutzen, um den Nutzern bessere Informationen, Suche und Empfehlungen zu bieten.

Evolutionary origin of type IV classical cadherins in arthropods.

Science.gov (United States)

Sasaki, Mizuki; Akiyama-Oda, Yasuko; Oda, Hiroki

2017-06-17

Classical cadherins are a metazoan-specific family of homophilic cell-cell adhesion molecules that regulate morphogenesis. Type I and type IV cadherins in this family function at adherens junctions in the major epithelial tissues of vertebrates and insects, respectively, but they have distinct, relatively simple domain organizations that are thought to have evolved by independent reductive changes from an ancestral type III cadherin, which is larger than derived paralogs and has a complicated domain organization. Although both type III and type IV cadherins have been identified in hexapods and branchiopods, the process by which the type IV cadherin evolved is still largely unclear. Through an analysis of arthropod genome sequences, we found that the only classical cadherin encoded in chelicerate genomes was the type III cadherin and that the two type III cadherin genes found in the spider Parasteatoda tepidariorum genome exhibited a complex yet ancestral exon-intron organization in arthropods. Genomic and transcriptomic data from branchiopod, copepod, isopod, amphipod, and decapod crustaceans led us to redefine the type IV cadherin category, which we separated into type IVa and type IVb, which displayed a similar domain organization, except type IVb cadherins have a larger number of extracellular cadherin (EC) domains than do type IVa cadherins (nine versus seven). We also showed that type IVa cadherin genes occurred in the hexapod, branchiopod, and copepod genomes whereas only type IVb cadherin genes were present in malacostracans. Furthermore, comparative characterization of the type IVb cadherins suggested that the presence of two extra EC domains in their N-terminal regions represented primitive characteristics. In addition, we identified an evolutionary loss of two highly conserved cysteine residues among the type IVa cadherins of insects. We provide a genomic perspective of the evolution of classical cadherins among bilaterians, with a focus on the Arthropoda

A pilot randomised controlled trial of negative pressure wound therapy to treat grade III/IV pressure ulcers [ISRCTN69032034

Science.gov (United States)

2012-01-01

Background Negative pressure wound therapy (NPWT) is widely promoted as a treatment for full thickness wounds; however, there is a lack of high-quality research evidence regarding its clinical and cost effectiveness. A trial of NPWT for the treatment of grade III/IV pressure ulcers would be worthwhile but premature without assessing whether such a trial is feasible. The aim of this pilot randomised controlled trial was to assess the feasibility of conducting a future full trial of NPWT for the treatment of grade III and IV pressure ulcers and to pilot all aspects of the trial. Methods This was a two-centre (acute and community), pilot randomised controlled trial. Eligible participants were randomised to receive either NPWT or standard care (SC) (spun hydrocolloid, alginate or foam dressings). Outcome measures were time to healing of the reference pressure ulcer, recruitment rates, frequency of treatment visits, resources used and duration of follow-up. Results Three hundred and twelve patients were screened for eligibility into this trial over a 12-month recruitment period and 12/312 participants (3.8%) were randomised: 6 to NPWT and 6 to SC. Only one reference pressure ulcer healed (NPWT group) during follow-up (time to healing 79 days). The mean number of treatment visits per week was 3.1 (NPWT) and 5.7 (SC); 6/6 NPWT and 1/6 SC participants withdrew from their allocated trial treatment. The mean duration of follow-up was 3.8 (NPWT) and 5.0 (SC) months. Conclusions This pilot trial yielded vital information for the planning of a future full study including projected recruitment rate, required duration of follow-up and extent of research nurse support required. Data were also used to inform the cost-effectiveness and value of information analyses, which were conducted alongside the pilot trial. Trial registration Current Controlled Trials ISRCTN69032034. PMID:22839453

A pilot randomised controlled trial of negative pressure wound therapy to treat grade III/IV pressure ulcers [ISRCTN69032034

Directory of Open Access Journals (Sweden)

Ashby Rebecca L

2012-07-01

Full Text Available Abstract Background Negative pressure wound therapy (NPWT is widely promoted as a treatment for full thickness wounds; however, there is a lack of high-quality research evidence regarding its clinical and cost effectiveness. A trial of NPWT for the treatment of grade III/IV pressure ulcers would be worthwhile but premature without assessing whether such a trial is feasible. The aim of this pilot randomised controlled trial was to assess the feasibility of conducting a future full trial of NPWT for the treatment of grade III and IV pressure ulcers and to pilot all aspects of the trial. Methods This was a two-centre (acute and community, pilot randomised controlled trial. Eligible participants were randomised to receive either NPWT or standard care (SC (spun hydrocolloid, alginate or foam dressings. Outcome measures were time to healing of the reference pressure ulcer, recruitment rates, frequency of treatment visits, resources used and duration of follow-up. Results Three hundred and twelve patients were screened for eligibility into this trial over a 12-month recruitment period and 12/312 participants (3.8% were randomised: 6 to NPWT and 6 to SC. Only one reference pressure ulcer healed (NPWT group during follow-up (time to healing 79 days. The mean number of treatment visits per week was 3.1 (NPWT and 5.7 (SC; 6/6 NPWT and 1/6 SC participants withdrew from their allocated trial treatment. The mean duration of follow-up was 3.8 (NPWT and 5.0 (SC months. Conclusions This pilot trial yielded vital information for the planning of a future full study including projected recruitment rate, required duration of follow-up and extent of research nurse support required. Data were also used to inform the cost-effectiveness and value of information analyses, which were conducted alongside the pilot trial. Trial registration Current Controlled Trials ISRCTN69032034.

Path integral approach for superintegrable potentials on spaces of non-constant curvature. Pt. 2. Darboux spaces D{sub III} and D{sub IV}

Energy Technology Data Exchange (ETDEWEB)

Grosche, C. [Hamburg Univ. (Germany). 2. Inst. fuer Theoretische Physik; Pogosyan, G.S. [Joint Inst. of Nuclear Research, Moscow (Russian Federation). Bogoliubov Lab. of Theoretical Physics]|[Guadalajara Univ., Jalisco (Mexico). Dept. de Matematicas CUCEI; Sissakian, A.N. [Joint Inst. of Nuclear Research, Moscow (Russian Federation). Bogoliubov Lab. of Theoretical Physics

2006-08-15

This is the second paper on the path integral approach of superintegrable systems on Darboux spaces, spaces of non-constant curvature. We analyze in the spaces D{sub III} and D{sub IV} five respectively four superintegrable potentials, which were first given by Kalnins et al. We are able to evaluate the path integral in most of the separating coordinate systems, leading to expressions for the Green functions, the discrete and continuous wave-functions, and the discrete energy-spectra. In some cases, however, the discrete spectrum cannot be stated explicitly, because it is determined by a higher order polynomial equation. We show that also the free motion in Darboux space of type III can contain bound states, provided the boundary conditions are appropriate. We state the energy spectrum and the wave-functions, respectively. (orig.)

Batteries and accumulators: everything you always wanted to know. Batteries, accumulators and the environment - questions and answers; Batterien und Akkus - Das wollten Sie wissen.. Fragen und Antworten zu Batterien, Akkus und Umwelt

Energy Technology Data Exchange (ETDEWEB)

Leuthold, S.; Minkos, A. (comps.)

2006-07-15

Batteries and accumulators are part of our everyday life. This brochure answers problems related to their use and disposal, chargers and charging. Starter batteries for motor vehicles are left out of account, as are special batteries e.g. for electric fences or lights on building sites. The brochure also explains the legal fundamentals for disposal of batteries and provides information on environmental problems relating to production and disposal. Frequently asked questions are answered on the final pages. [German] Batterien und Akkus begleiten unseren Alltag. Solange sie die noetige mobile Versorgung ermoeglichen, sind sie gern gesehen. Versagen sie ihren Dienst, beginnen die Probleme: Wohin mit der leeren Batterie, dem nicht mehr funktionsfaehigen Akku (Keinesfalls in den Hausmuell.)? Welches ist das richtige Ladegeraet und das richtige Ladeverfahren fuer den Akku? Zu diesen und anderen Fragen rund um Geraetebatterien und -akkus gibt diese Broschuere Auskunft. Nicht betrachtet werden hier allerdings Starterbatterien (z.B. fuer Autos und Motorraeder) und bestimmte Spezialbatterien (z.B. fuer Weidezaeune oder Baustellenlampen), die einen Sonderfall darstellen. Die Broschuere erlaeutert auch die gesetzlichen Grundlagen fuer die Entsorgung unbrauchbarer Batterien und Akkus und gibt Informationen zur Umweltbelastung durch Herstellung und Entsorgung. Am Ende der Broschuere werden haeufig gestellte Fragen und deren Antworten zusammengestellt.

Mensch und Maschine in Übersetzungsprozessen

DEFF Research Database (Denmark)

Hansen, Gyde

2014-01-01

gebrauchstauglich sein. In meinem empirischen Projekt zur Erforschung notwendiger Kompetenzen, zum Übersetzen, Revidieren und zum Pre- und Post-Editing, TraREdit, arbeite ich mit den Sprachen Deutsch, Dänisch und Englisch. Trotz offensichtlicher Mängel von Maschinenübersetzungen muss man erkennen, dass diese besser...

[Das Bild und die Wahrnehmung der Stadt und der städtischen Gesellschaft im Hanseraum im Mittelalter und in der frühen Neuzeit] / Juhan Kreem

Index Scriptorium Estoniae

Kreem, Juhan

2009-01-01

Arvustus: Das Bild und die Wahrnehmung der Stadt und der städtischen Gesellschaft im Hanseraum im Mittelalter und in der frühen Neuzeit. hrsg. v. Roman Czaja. Torun, 2004. Torunis 2002. aastal toimunud konverentsi materjalid. Projekti "Pilt ja linn" raames ilmunud publikatsioonide loendit saab näha aadressil http://www.historiaurbium.org/english/attivita_images_en.html.

Textbook with exercises on automation and process control. An introduction for engineers, industrial engineers and experts in business economics; Lehr- und Uebungsbuch Automatisierungs- und Prozessleittechnik. Eine Einfuehrung fuer Ingenieure, Wirtschaftsingenieure und Betriebswirtschaftler

Energy Technology Data Exchange (ETDEWEB)

Bergmann, J. [Hochschule fuer Technik, Wirtschaft und Sozialwesen Zittau/Goerlitz (FH), Zittau (Germany)

1999-07-01

This textbook addresses students at university level. It contains many examples and exercises and presents a detailed explanation of modelling in automation engineering, including equations and algorithms. Important problems of automation and their solutions are illustrated by an exemplary process control problem that recurs in the book and can be recalculated on the reader's PC. A CD-ROM is enclosed with a process automation system that can be analyzed and tested in several variants. [German] Dieses Lehr- und Uebungsbuch zur Automatisierungs- und Prozessleittechnik - eignet sich fuer die Ausbildung an Technischen Hochschulen, Fachhochschulen und Berufsakademien - ist fuer Studenten mit Automatisierungs- und Prozessleittechnik im Nebenfach konzipiert - enthaelt eine fuer das Grundverstaendnis notwendige, mit vielen Beispielen und Uebungen ergaenzte Lehrstoffauswahl - erlaeutert sehr verstaendlich die spezielle Modellwelt der Automatisierungstechnik mit ihren Beschreibungsformen und Loesungsalgorithmen - behandelt wesentliche Problemstellungen der Automatisierung und deren Loesungen anhand einer durchgaengigen, am Rechner nachvollziehbaren Prozessleitaufgabe. Das auf der beigefuegten CD-ROM visualisierte Prozessautomatisierungssystem kann in Variationen analysiert und getestet werden. (orig.)

Neue Technologien und Erziehung/Bildung

Directory of Open Access Journals (Sweden)

Norbert Meder

2015-03-01

Full Text Available Es wird gezeigt, dass Computertechnologie zur pädagogischen Aufgabe wird, weil es sich um eine Kulturtechnik handelt. Ausgehend vom Begriff der Bildung als Ausbildung eines Verhältnisses zu mir selbst, zu anderen und zur Welt wird Computertechnologie als Problemlösungsautomat, Sprachentwicklungsmaschine, Simulationsmaschine, Kommunikationsmaschine, Bildschirmgestaltungsmaschine, Schlüsselloch und Superzeichenmaschine analysiert. Die Analyse zeigt, daß Computertechnologie ein neues Bildungsideal erforderlich macht: Den Sprachspieler. Der Sprachspieler kennt sein doppelt reflexives Verhältnis zu sich selbst, zu anderen und zur Welt und beherrscht so das Spiel mit der Sprache zur Ausübung von Macht und Gewalt in der Informationsgesellschaft. Der Text geht in folgenden Schritten vor: Zunächst werden mit den Begriffen "Kulturtechnik" und "Bildung" die Prinzipien der Analyse bestimmt. Anschließend wird eine Sachanalyse der Computertechnologie durchgeführt und die gefundenen Eigenschaften jeweils in Relation zum Kulturtechnik- und Bildungsbegriff gesetzt. Computer technology becomes a challenge for education if it is understood as a cultural technology. Starting with the term bildung as the formation of relations to my self, to others and the world, computer technology is analysed as problem solving machine, language development machine, simulation machine, communication machine, screen design machine, keyhole, and super sign machine. It is shown, that computertechnology reqiures a new ideal for bildung: the language player. The language player knows his double reflective relation to his self, to others and the world and thus rules the game with language that is used to excercise power and force in the information society. The text argues in the following steps: At first the principles of the analyses are defined with the terms cultural technology and bildung. Susequently, computer technology is analysed. The identified qualities are finally

Long-term outcome of stapled transanal rectal resection (STARR) versus stapled hemorrhoidopexys (STH) for grade III-IV hemorrhoids: preliminary results.

Science.gov (United States)

Zanella, Simone; Spirch, Saverio; Scarpa, Marco; Ricci, Francesco; Lumachi, Franco

2014-01-01

Circular stapled transanal hemorrhoidopexy (STH) was first introduced by A. Longo for the correction of internal mucosal prolapse and obstructed defecation and in 1998, was proposed as alternative to conventional excisional hemorrhoidectomy. More recently, stapled transanal rectal resection (STARR) has gradually gained popularity, as the Longo procedure, in the treatment of hemorrhoids. The aim of our study was to evaluate the usefulness of STARR as alternative to STH in patients with grade III (n=218, 68.1%) and IV (n=102, 31.9%) hemorrhoids. A group of 320 consecutive patients (median age=51 years; range=16-85) underwent STH (n=281) or STARR (n=39) procedure. The rate of postoperative bleeding (53.8% vs. 74.4%, phemorrhoids and a lower incidence of prolapse, both at one year (none vs. 1.4%, p=0.593 and 2.6% vs. 5.3%, p=0.396, respectively) and at two years (none vs. 6.8%, p=0.078 and none vs. 13.2%, p=0.012, respectively). The one-year (9.0 ± 1.8 vs. 9.4 ± 0.7, p=0.171) and two-year (9.6 ± 0.8 vs. 9.1 ± 1.7, p=0.072) general satisfaction was similar but higher in STARR patients than in the STH group. In conclusion, according to our preliminary results, the STARR procedure leads to a lower incidence of complications and recurrences and should be considered for patients with grade III or IV hemorrhoids previously selected for stapled hemorrhoidectomy, as a promising alternative to STH. Copyright © 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Supraleitung Grundlagen und Anwendungen

CERN Document Server

Buckel, Werner

2004-01-01

Seit nunmehr drei Jahrzehnten ist der "Buckel" das Referenzwerk in deutscher Sprache zum Thema Supraleitung. Immer wieder aktualisiert, hat das Lehrbuch Generationen von Studenten begleitet. In der 6., vollständig überarbeiteten Auflage wird das bewährte didaktische Konzept beibehalten, inhaltlich wurde der Band dem aktuellen Stand von Forschung und Technik angepasst. Das Autorenteam um Prof. Kleiner verzichtet auf komplizierte mathematische Herleitungen. Es baut ganz auf das bewährte Step-by-Step-Prinzip: Der Schwierigkeitsgrad wird von Kapitel zu Kapitel gesteigert. So können auch Einsteiger ohne einschlägige Vorkenntnisse dem Stoff bequem folgen. Dank seiner klaren Sprache und zahlreicher Abbildungen eignet sich der Band hervorragend als einführendes Lehrbuch - und zwar nicht nur für Physik-Studenten, sondern auch für Studierende angrenzender Natur- und Ingenieurwissenschaften. Grundlegende Eigenschaften, supraleitende Elemente, Cooper-Paarung, Thermodynamik, kritische Ströme, Josephsonkontakte...

Frauen in Philosophie und Wissenschaft

Directory of Open Access Journals (Sweden)

Regina Harzer

2006-03-01

Full Text Available Der von Brigitte Doetsch herausgegebene Band präsentiert die aktuelle Feministische Philosophie und sammelt Beiträge, die Einblick geben in den gegenwärtigen Forschungsstand, wie ihn „Philosophinnen im dritten Jahrtausend“ erreicht haben. Insgesamt neun, zum Teil interdisziplinär ausgerichtete Arbeiten werden vorgestellt. Das Themenspektrum ist weit: Geschichte der Philosophie; Politische Philosophie und Naturphilosophie; Epistemologie; Biopolitik und Bioethik als Bereiche praktischer Philosophie; Forschung über Geschlechterverhältnisse. Alle Beiträge gehen zurück auf eine Vortragsreihe des Braunschweiger Zentrums für Gender Studies (www.genderzentrum.de. Leser/-innen erhalten einen guten Überblick über die aktuelle Frauenforschung aus der Sicht theoretischer und praktischer Philosophie.

Quantitative Analyse und Visualisierung der Herzfunktionen

Science.gov (United States)

Sauer, Anne; Schwarz, Tobias; Engel, Nicole; Seitel, Mathias; Kenngott, Hannes; Mohrhardt, Carsten; Loßnitzer, Dirk; Giannitsis, Evangelos; Katus, Hugo A.; Meinzer, Hans-Peter

Die computergestützte bildbasierte Analyse der Herzfunktionen ist mittlerweile Standard in der Kardiologie. Die verfügbaren Produkte erfordern meist ein hohes Maß an Benutzerinteraktion und somit einen erhöhten Zeitaufwand. In dieser Arbeit wird ein Ansatz vorgestellt, der dem Kardiologen eine größtenteils automatische Analyse der Herzfunktionen mittels MRT-Bilddaten ermöglicht und damit Zeitersparnis schafft. Hierbei werden alle relevanten herzphysiologsichen Parameter berechnet und mithilfe von Diagrammen und Graphen visualisiert. Diese Berechnungen werden evaluiert, indem die ermittelten Werte mit manuell vermessenen verglichen werden. Der hierbei berechnete mittlere Fehler liegt mit 2,85 mm für die Wanddicke und 1,61 mm für die Wanddickenzunahme immer noch im Bereich einer Pixelgrösse der verwendeten Bilder.

Nutzerorientiertes Management von materiellen und immateriellen Informationsobjekten

OpenAIRE

Hübsch, Chris

2001-01-01

Schaffung einer stabilen, erweiterbaren und skalierbaren Infrastruktur für die Bereitstellung von Diensten im Umfeld von Bibliotheken und ähnlichen wissensanbietenden Einrichtungen unter Verwendung von XML-RPC und Python.

Gestaltung einer netzbasierten Lernumgebung für einen Fernstudiengang zu „Medien und Informationstechnologien in Erziehung, Unterricht und Bildung“

Directory of Open Access Journals (Sweden)

Gerhard Tulodziecki

2017-07-01

Full Text Available In diesem Beitrag stelle ich dar, wie wir in einem kooperativen Verbund eine netzbasierte Lernumgebung für einen Fernstudiengang zu „Medien und Informationstechnologien in Erziehung, Unterricht und Bildung“ gestalten. Das Projekt wird von zwei Arbeitsgruppen an der Universität Paderborn (Allgemeine Didaktik und Medienpädagogik, Didaktik der Informatik und einer Arbeitsgruppe an der Fernuniversität Hagen (Theorie der Schule und des Unterrichts getragen. Die Projektleitung teile ich mit Horst Dichanz, Bardo Herzig und Johannes Magenheim. Der Fernstudiengang basiert auf Entwicklungen zur Lehrerausbildung im Bereich neuer Medien, wie sie im Rahmen der Initiative „Bildungswege in der Informationsgesellschaft (BIG“ erarbeitet wurden (vgl. u.a. Tulodziecki/Moll/Gallasch 2001. Die – 1995 begonnene – BIG-Initiative geht auf die Bertelsmann Stiftung und Heinz Nixdorf Stiftung zurück. Die jetzige Projektarbeit wird von der ,,e-nitiative.nrw.Netzwerk für Bildung“ gefördert.

Report for 2011 from the Bordeaux IVS Analysis Center

Science.gov (United States)

Charlot, Patrick; Bellanger, Antoine; Bourda, Geraldine; Collioud, Arnaud; Baudry, Alain

2012-01-01

This report summarizes the activities of the Bordeaux IVS Analysis Center during the year 2011. The work focused on (i) regular analysis of the IVS-R1 and IVS-R4 sessions with the GINS software package; (ii) systematic VLBI imaging of the RDV sessions and calculation of the corresponding source structure index and compactness values; (iii) imaging of the sources observed during the 2009 International Year of Astronomy IVS observing session; and (iv) continuation of our VLBI observational program to identify optically-bright radio sources suitable for the link with the future Gaia frame. Also of importance is the enhancement of the IVS LiveWeb site which now comprises all IVS sessions back to 2003, allowing one to search past observations for session-specific information (e.g. sources or stations).

CLILiG und Musikunterricht

Directory of Open Access Journals (Sweden)

Merle Jung

2015-10-01

Full Text Available Der Einsatz von Musik und Liedern im Sprachunterricht ist seit der Entwicklung der kommunikativen Methoden ein beliebtes Thema in der Fremdsprachendidaktik. Musik und Sprache haben Ähnlichkeiten bei den kognitiven Verarbeitungsprozessen und der gedächtnisstützende Einfluss der Musik und ihr Nutzen für das Sprachenlernen sind allgemein bekannt. Dieser Nutzen wird aber meistens nur aus der (fremdsprachlichen Perspektive gezogen, die musikalische Erziehung der Lernenden bleibt im Hintergrund. Dabei bietet der bilinguale Musikunterricht mit der klaren Ausrichtung auf die musikalischen Ziele eine gute Möglichkeit, diese zwei Bereiche – Musik und Sprache – gleichwertig miteinander zu verbinden. Das Ziel des vorliegenden Beitrags ist es, die Vorteile des bilingualen Musikunterrichts zu erörtern und an einem Beispielmodul zum Thema Wetter im Herbst zu verdeutlichen. The use of music and songs in language teaching has been a popular topic in foreign language didactics since the development of communicative methods. Music and language have similarities in cognitive processing and the memory supporting influence of music and its beneficial effect on language learning are generally known. However, this benefit will usually be drawn only from the (foreign language perspective, the musical education of the learners remains in the background. Yet bilingual music education with a clear focus on the musical goals provides a great opportunity to connect these two areas - music and language - equally to each other. The aim of this paper is to discuss the advantages of bilingual music education and to present an example based on the bilingual module Weather in Autumn.

Diagrammatik und Wissensorganisation

Directory of Open Access Journals (Sweden)

Sascha Freyberg

2012-11-01

Full Text Available EinleitungDie Formen des „Sichtbarmachens“ in der Wissenschaft reichen von „Abbildungen“ über „Modelle“ bis hin zu „Simulationen“. Sie können u.a. gezeichnet, fotografiert, geometrisch konstruiert oder durch Sensorik vermittelt, digital prozessiert werden. Ihre Funktionen erstrecken sich von der Orientierung bis hin zur (hypothetischen Voraussage und somit auch vom Überblick bis zur Evidenzsuggestion. Generell handelt es sich um vereinfachte (und vereinfachende Darstellungen von (teilweise sehr komplexen Sachverhalten, zu deren Verständnis sie beitragen sollen; daher können sie bei Lernprozessen, d.h. in der Vermittlung und auch bei der Organisation von Wissen eine wichtige Rolle spielen. Diese kommt ihnen nun nicht nur zu, weil sie – wie in den mittelalterlichen Mnemotechniken – als Gedächtnisstützen für bekannte Sachverhalte dienen. Sondern resultiert auch aus ihrem Potenzial für die Entdeckung von neuen Zusammenhängen. Der folgende Artikel diskutiert die Darstellungsform des Diagramms. Es wird hier mit dem Gedanken gespielt, dass die in der universalen Zeichentheorie von C.S. Peirce entwickelte Diagrammatik wichtige Impulse für eine Untersuchung des Zusammenhangs von Wissen und Bildlichkeit geben kann.

Calculation of activity concentration and dose rates from online radioactivity measurement in primary coolant channel of TAPS-III and IV

International Nuclear Information System (INIS)

Chaudhury, Sanhita; Agarwal, Chhavi; Goswami, A.; Mhatre, Amol; Chaturvedi, T.P.; Tawde, N.; Gathibandhe, Manohar; Dash, S.C.

2011-05-01

Radioactivity measurement using CdZnTe detector and dose measurement using teletector were done at several locations of primary heat transport (PHT) system of the Tarapur Atomic Power Station-III and IV reactor during shut down as well as operating condition of the reactors. The detector efficiency for the required counting geometry was simulated using MCNP code. Using this simulated efficiency and the experimental count rate (cps), the activity concentrations (Bq/mL) of different radionuclides in coolant water were calculated. The dose rates for the counted locations were also simulated using Monte Carlo code and it matched well with the experimentally obtained dose rate. (author)

Fractures of the atlantoaxial complex in the elderly: assessment of radiological spectrum of fractures and factors influencing imaging diagnosis; Frakturen des Atlas und Axis bei aelteren Patienten: Untersuchung des Radiologischen Spektrums der Frakturen und bedeutsamer Faktoren fuer die Bildgebende Diagnostik

Energy Technology Data Exchange (ETDEWEB)

Lomoschitz, F.M. [Universitaetsklinik fuer Radiodiagnostik, AKH Wien, Wien (Germany); Dept. of Radiology, Harborview Medical Center, Univ. of Washington, Seattle, WA (United States); Blackmore, C.C.; Linnau, K.F.; Mann, F.A. [Dept. of Radiology, Harborview Medical Center, Univ. of Washington, Seattle, WA (United States); Stadler, A. [Universitaetsklinik fuer Radiodiagnostik, AKH Wien, Wien (Germany)

2004-02-01

Objective: to describe patterns of atlantoaxial fractures in a population of consecutive elderly patients, including assessment of type, distribution and associated clinical and radiological findings, and to analyze any influence of the causative trauma mechanism on the individual fracture pattern. Materials and methods: the distribution and type of 123 atlantoaxial fractures in 95 subjects older than 65 years (range: 65-102; mean age: 79 years) were retrospectively assessed. For each subject, trauma mechanism and clinical and neurological status were recorded at admission. Initial imaging studies of the cervical spine were reviewed. Preexistent degenerative changes were assessed and the atlantoaxial fractures classified. Data were evaluated for the frequency of different types of fractures of C1 and C2 and for accompanying fractures of cervical vertebrae or the occipital condyles, respectively. Results: the majority of patients with injuries of the atlantoaxial complex had fractures of C2 (90 of 95, 95%). A large proportion of these patients (67 of 90, 74%) had odontoid fractures. An isolated fracture of C1 was present in only 5 (5%) patients. Associated fractures of the occipital condyles or other cervical vertebrae were rare (10 of 95, 11%). The main trauma mechanism for atlantoaxial injuries was a fall (56 of 95, 59%). Elderly patients injured in motor vehicle accidents were more likely to have isolated fractures of C2 and Type III fractures of the odontoid (p < 0.02). Conclusion: in elderly patients, fractures of the atlantoaxial complex are mainly caused by falls and almost always involve C2. The trauma mechanism influences the fracture pattern (orig.) [German] Untersuchung von Frakturen des Atlas (C1) und Axis (C2) in einer konsekutiven Population aelterer Patienten ({>=} 65 Jahre) hinsichtlich Fraktur-Typus, -Haeufigkeit, und -Kombinationen, und Analyse von assoziierter Klinik sowie Einfluss von unfall-ursaechlichen Faktoren auf Frakturen des atlanto

Indirect MR venography: contrast medium protocols, postprocessing and combination in diagnosing pulmonary emboli with MRI; Indirekte MR-Phlebografie: Kontrastmittelprotokolle, Nachverarbeitung und Kombination mit Lungenemboliediagnostik in der MRT

Energy Technology Data Exchange (ETDEWEB)

Kluge, A.; Bachmann, G. [Diagnostische Radiologie, Kerckhoff-Klinik, Bad Nauheim (Germany); Rominger, M. [Diagnostische Radiologie, Phillips-Univ. Marburg (Germany); Schoenburg, M. [Herzchirurgie, Kerckhoff-Klinik, Bad Nauheim (Germany)

2004-07-01

Purpose: Integration of MR venography in a comprehensive MR imaging protocol in patients with suspected pulmonary embolism (PE) and evaluation of contrast media dosage, timing and postprocessing for diagnostic accuracy. Materials and Methods: Fortyeight consecutive inpatients with suspected PE or deep vein thrombosis were examined by MR venography according to one of the following protocols: protocol I: MR venography only, 0.25 mmol/kg bodyweight (BW) Gadopentate dimeglumine(Gd-DTPA) as single dose, bolus timing; protocol II: MR angiography of pulmonary arteries with a cumulative dosage of 0.25 mmol/kg contrast media, modification of coil setting for MR venography without further contrast media application; protocol III: as protocol II but with 0.125 mmol/kg BW, followed by MR venography. Signal-to-noise ratio, contrast-to-noise ratio, number of definable vascular segments and image quality were evaluated. The results were compared to conventional bilateral venography. Results: All MR venography examinations were of diagnostic quality and the examination time was below 10 min. MR venography could be performed in all 48 patients comparted to 43 of 48 patients for conventional venography. Significantly more superficial and deep veins of the leg could be visualized by MR venography (94% compared to 83% for conventional venography). Sensitivity and specificity were 100% and 92%, respectively. Quality differed significantly between 0.125 mmol/kg (protocol III) and 0.25 mmol/kg Gd-DTPA (protocols I and II) while timing did not influence quality (protocol I vs. II). (orig.) [German] Ziel: Integration der MR-Phlebografie in ein umfassendes Konzept der MRT-Diagnostik bei Verdacht auf Lungenembolie (LE). Untersuchung des Einflusses von Kontrastmittelmenge, -bolusform und Verzoegerungszeit sowie der Nachverarbeitung auf die diagnostische Qualitaet von MR-Phlebografien. Material und Methode: Bei 48 konsekutiven stationaeren Patienten mit Verdacht auf Beinvenenthrombose (TVT

Chelation and stabilization of berkelium in oxidation state +IV

Science.gov (United States)

Deblonde, Gauthier J.-P.; Sturzbecher-Hoehne, Manuel; Rupert, Peter B.; An, Dahlia D.; Illy, Marie-Claire; Ralston, Corie Y.; Brabec, Jiri; de Jong, Wibe A.; Strong, Roland K.; Abergel, Rebecca J.

2017-09-01

Berkelium (Bk) has been predicted to be the only transplutonium element able to exhibit both +III and +IV oxidation states in solution, but evidence of a stable oxidized Bk chelate has so far remained elusive. Here we describe the stabilization of the heaviest 4+ ion of the periodic table, under mild aqueous conditions, using a siderophore derivative. The resulting Bk(IV) complex exhibits luminescence via sensitization through an intramolecular antenna effect. This neutral Bk(IV) coordination compound is not sequestered by the protein siderocalin—a mammalian metal transporter—in contrast to the negatively charged species obtained with neighbouring trivalent actinides americium, curium and californium (Cf). The corresponding Cf(III)-ligand-protein ternary adduct was characterized by X-ray diffraction analysis. Combined with theoretical predictions, these data add significant insight to the field of transplutonium chemistry, and may lead to innovative Bk separation and purification processes.

Social Bots und Fake News - Was EU- und UNESCO-Referenzrahmen zum Lernen im digitalen Zeitalter darüber (nicht sagen

Directory of Open Access Journals (Sweden)

Dietmar Janetzko

2017-07-01

Full Text Available In den letzten Jahren haben internationale Organisationen wie die EU und die UNESCO eine Reihe von Vorschlägen und Strategiepapieren zur Bildung und Ausbildung im Zusammenhang mit digitalen Medien entwickelt. Mit den dabei entstandenen Rahmenkonzepten der EU (Digital Competence, DigComp sowie der UNESCO (Media and Information Literacy, MIL werden im Kern zwei zusammenhängende Ziele verfolgt: (i digitale Bildung bzw. digitale Kompetenzen, Fähigkeiten und zugehörige Einstellungen umfassend zu kartographieren sowie (ii über die dabei konzipierten edukativ-politischen Rahmenkonzepte Projektförderungen, Bildungs- bzw. Ausbildungsinitiativen sowie Gesetzesvorlagen anzustossen. Tatsächlich sind DigComp und MIL bereits dabei, auf internationaler Ebene einen prägenden Einfluss zu nahezu allen Fragen der Bildung und Ausbildung im Bereich digitaler Medien auszuüben. Beide Initiativen haben innerhalb der genannten Organisationen Leuchtturmcharakter, werden bislang aber von der allgemeinen Öffentlichkeit und der medienpädagogischen Fachöffentlichkeit kaum wahrgenommen. Dessen ungeachtet verbindet sich mit DigComp und MIL jeweils ein impliziter Anspruch auf einen – im Bedarfsfall zu aktualisierenden – Gesamtentwurf zur Analyse und Gestaltung medienpädagogischer Bildung und Ausbildung. Dies gilt für Gesetzesvorlagen, Regulierungen, Forschungsaktivitäten. Sind diese Rahmenkonzepte anschlussfähig an medienpädagogische Debatten über disruptive Versuche, in via soziale Medien geführte öffentliche Debatten einzugreifen, die sich über social bots, fake news oder andere Formen der Einflussnahme manifestieren? Erschliessen sie dazu Reflexionsräume und Handlungsoptionen? Geleitet von diesen Fragen betrachtet der vorliegende Aufsatz, die Rahmenkonzepte der EU und UNESCO, DigComp and MIL. Dabei zeigt sich, dass beide Rahmenkonzepte von Schieflagen gekennzeichnet sind. DigComp und MIL überbetonen die instrumentelle, auf Verwertung am

Alimentos industrializados congelados gama III y IV

OpenAIRE

Tupone Reverter, Paula

2012-01-01

El presente estudio tiene como objetivo, indagar sobre el consumo, el grado de información y contenido de sodio, grasas saturadas y colesterol de los principales alimentos congelados Gama III y V consumidos por los encuestados. A partir de esto, se realiza una encuesta de frecuencia de consumo y preguntas varias a 250 personas de entre 30 a 60 años, que concurren a cuatro supermercados de la ciudad de Mar del Plata, para determinar el conocimiento por parte de los encuestados e...

MODERATE C IV ABSORBER SYSTEMS REQUIRE 10{sup 12} M{sub Sun} DARK MATTER HALOS AT z {approx} 2.3: A CROSS-CORRELATION STUDY OF C IV ABSORBER SYSTEMS AND QUASARS IN SDSS-III BOSS DR9

Energy Technology Data Exchange (ETDEWEB)

Vikas, Shailendra; Wood-Vasey, W. Michael [Pittsburgh Particle Physics, Astrophysics, and Cosmology Center (PITT PACC), Department of Physics and Astronomy, University of Pittsburgh, Pittsburgh, PA 15260 (United States); Lundgren, Britt [Department of Physics, Yale University, New Haven, CT 06511 (United States); Ross, Nicholas P. [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, Berkeley, CA 92420 (United States); Myers, Adam D. [Department of Physics and Astronomy, University of Wyoming, Laramie, WY 82071 (United States); AlSayyad, Yusra [Department of Astronomy, University of Washington, Seattle, WA 98195 (United States); York, Donald G. [Department of Astronomy, University of Chicago, 5640 S. Ellis Ave, Chicago, IL 60637 (United States); Schneider, Donald P. [Department of Astronomy and Astrophysics, Pennsylvania State University, University Park, PA 16802 (United States); Brinkmann, J.; Bizyaev, Dmitry; Brewington, Howard; Malanushenko, Elena; Malanushenko, Viktor; Oravetz, Daniel; Pan, Kaike; Snedden, Stephanie [Apache Point Observatory, P.O. Box 59, Sunspot, NM 88349-0059 (United States); Ge, Jian [Department of Astronomy, University of Florida, Gainesville, FL 32611 (United States); Muna, Demitri [Center for Cosmology and Particle Physics, New York University, New York, NY 10003 (United States); Paris, Isabelle; Petitjean, Patrick, E-mail: skv4@pitt.edu [UPMC-CNRS, UMR7095, Institut d' Astrophysique de Paris, F-75014 Paris (France); and others

2013-05-01

We measure the two-point cross-correlation function of C IV absorber systems and quasars, using spectroscopic data from the Sloan Digital Sky Survey III Baryon Oscillation Spectroscopic Survey (BOSS; Data Release 9). The 19,701 quasars and 6149 C IV ''moderate'' absorbers, 0.28 A < rest-frame equivalent width (EW) < 5 A, in our study cover a redshift range of 2.1 < z < 2.5 over 3300 deg{sup 2} and represent a factor of two increase in sample size over previous investigations. We find a correlation scale length and slope of the redshift-space cross-correlation function of s{sub 0} = 8.46 {+-} 1.24 Mpc, {gamma} = 1.68 {+-} 0.19, in the redshift-space range 10 < s < 100 Mpc. We find a projected cross-correlation function of C IV absorption systems and quasars of r{sub 0} = 7.76 {+-} 2.80 Mpc, {gamma} = 1.74 {+-} 0.21. We measure the combined quasar and C IV bias to be b{sub QSO} b{sub C{sub IV}} = 8.81 {+-} 2.28. Using an estimate of b{sub QSO} from the quasar auto-correlation function we find b{sub CIV} = 2.38 {+-} 0.62. This b{sub CIV} implies that EW > 0.28 A C IV absorbers at z {approx} 2.3 are typically found in dark matter halos that have masses {>=}10{sup 11.3}-10{sup 13.4} M{sub Sun} at that redshift. The complete BOSS sample will triple the number of both quasars and absorption systems and increase the power of this cross-correlation measurement by a factor of two.

Delegation und Kooperation im Gesundheitswesen

OpenAIRE

Rosenau, Henning

2010-01-01

Delegation und Kooperation im Gesundheitswesen. - In: Tıpta işbirliği ve hukuksal sorunlar = Delegation und Kooperation im Gesundheitswesen / ed.: Hakan Hakeri ... - Samsun : Adalet, 2010. - S. 7-18

Lew Kopelew - der Schriftsteller und Wissenschaftler, der Freund der Menschen und Verfechter ihrer Grundrechte

OpenAIRE

Keller, Werner

2010-01-01

Unsere Erwartung war anders als sonst – freudig, doch nicht frei von Erregung und leiser Furcht: Wird man im Kreml das gegebene Wort halten und nach einem Jahr die Rückkehr in die russische Heimat erlauben? Als Gast Heinrich Bölls kam Lew Kopelew im November 1980 nach Deutschland. In der Bonner Wohnung des Slawisten Wolfgang Kasack konnte ich mich ihm wenige Tage später vorstellen: Er war groß, von beeindruckender Physiognomie – nicht nur durch den Prophetenbart –, allerdings fast bleich und ...

Radiation protection in category III large gamma irradiators

International Nuclear Information System (INIS)

Costa, Neivaldo; Furlan, Gilberto Ribeiro; Itepan, Natanael Marcio

2011-01-01

This article discusses the advantages of category III large gamma irradiator compared to the others, with emphasis on aspects of radiological protection, in the industrial sector. This category is a kind of irradiators almost unknown to the regulators authorities and the industrial community, despite its simple construction and greater radiation safety intrinsic to the model, able to maintain an efficiency of productivity comparable to those of category IV. Worldwide, there are installed more than 200 category IV irradiators and there is none of a category III irradiator in operation. In a category III gamma irradiator, the source remains fixed in the bottom of the tank, always shielded by water, negating the exposition risk. Taking into account the benefits in relation to radiation safety, the category III large irradiators are highly recommended for industrial, commercial purposes or scientific research. (author)

Stabile KHK und Hypertonie: Diagnostik, medikamentöse Therapie und Revaskularisierungsstrategien

OpenAIRE

Elsner D

2008-01-01

Nicht nur eine koronare Herzerkrankung (KHK) sondern auch Mikrozirkulationsstörungen führen bei Hypertonikern häufig zum Symptom der Angina pectoris. Grundpfeiler in der Diagnostik der KHK sind die entsprechenden Belastungstests. Allerdings ist die Aussagekraft bei Hypertonikern, insbesondere von Belastungs- EKG und Myokardszintigramm, eingeschränkt. Goldstandard bleibt daher die Koronarangiographie. Basis der Therapie der KHK ist die Modifikation des Lebensstils und Ausschaltung bz...

Schaulust und Horror Soziokulturelle - Perspektiven auf PEEPING TOM

Directory of Open Access Journals (Sweden)

Thomas Ballhausen

2010-09-01

Full Text Available Die Geschichte des Kinos und des Films ist mindestens ebenso sehr eine Geschichte des Schreckens (und der damit verbundenen Schaulust wie sie eine Geschichte des Dokumentarischen zu sein scheint. Es sind die außergewöhnlichen Körper und deren Bewegungen, die das Publikum zu allen Zeiten faszinierten, schockierten und zum Schauen und Sehen lockten. Besonders das Genre des Horrorfilms ist mit diesem zentralen Aspekt des Kinos besonders deutlich verbunden.

Konstruieren von Pkw-Karosserien: Grundlagen, Elemente und Baugruppen, Vorschriftenübersicht, Beispiele mit CATIA V4 und V5

Science.gov (United States)

Grabner, Jörg; Nothhaft, Richard

Die Faszination, die vom Auto ausgeht, ist und bleibt ungebrochen. Entsprechend interessant ist es, sich vor dem Hintergrund konventioneller Konstruktionstechniken über die virtuelle Produktentwicklung von Pkw-Karosserien an modernen CAD-Arbeitsplätzen informieren zu können. Die Autoren führen in die Grundlagen ein und zeigen anhand von Beispielen und zahlreichen Abbildungen, wie mit dem System CATIA der Rohbau sowie die Ausstattung innen und au=C3=9Fen konstruiert werden. Darüber hinaus wird das so genannte "Package" an Beispielen beschrieben, also das Management und die Harmonisierung der Anforderungen an die Bauräume (z.

Wie schneiden Sie ab?: Studie über Kontroll- und Prüfungsaktivitäten bei mittelgrossen Unternehmen, Spitälern und Hochschulen in der Schweiz

OpenAIRE

Ruud, T F; Isufi, S; Friebe, P; Stebler, W; Seheri, F; Emmenegger, M

2008-01-01

Kontroll- und Prüfungsaktivitäten unterstützen den Verwaltungsrat und die Geschäftsleitung bei der Steuerung und Kontrolle des Unternehmens. Bei mittelgrossen Unternehmen ist aufgrund der begrenzten personellen und finanziellen Ressourcen ein effektiver und effizienter Einsatz dieser Aktivitäten unerlässlich. Auch bei Spitälern und Hochschulen gewinnen Kontroll- und Prüfungsaktivitäten infolge erhöhter Wettbewerbsintensität und steigenden Kostendrucks sowie zunehmender Unabhängigkeit diese...

The new concept of hyphenated analytical system: Simultaneous determination of inorganic arsenic(III), arsenic(V), selenium(IV) and selenium(VI) by high performance liquid chromatography-hydride generation-(fast sequential) atomic absorption spectrometry during single analysis

International Nuclear Information System (INIS)

Niedzielski, P.

2005-01-01

The paper presents a new conception of determination of inorganic speciation forms of arsenic: As(III) and As(V) as well selenium Se(IV) and Se(VI) by means of the high performance liquid chromatography hyphenated with a detection by the atomic absorption spectrometry with hydride generation (HPLC-HG-AAS). The application of optimization procedure conditions of chromatographic separation of arsenic and selenium speciation forms (using anion-exchange Supelco LC-SAX1 column and phosphate buffer at pH 5.40 as a mobile phase) as well as the use of the atomic absorption spectrometry as a detector, which enables work in fast sequential mode, allowed to develop original detection methodology of simultaneous determination of arsenic As(III), As(V) and selenium Se(IV) and Se(VI) speciation forms within a 220 s single analysis. The obtained detection limits were 7.8 ng mL -1 for As(III); 12.0 ng mL -1 for As(V); 2.4 ng mL -1 for Se(IV) and 18.6 ng mL -1 for Se(VI) and precision 10.5%, 12.1%, 14.2% and 17.3%, respectively, for 100 ng mL -1 . The described method was used for ground water analysis

Personen- und Güterverkehr

Science.gov (United States)

Flämig, Heike; Gertz, Carsten; Mühlhausen, Thorsten

Im Jahr 2010 war in Deutschland der Verkehrssektor für fast 20 % der energiebedingten Treibhausgase verantwortlich. Das Klima hat sich bereits so weit verändert, dass zur Sicherung der Funktion der Verkehrssysteme auch Anpassungsmaßnahmen notwendig sind. Diese Maßnahmen müssen durch verkehrsreduzierende bzw. -beeinflussende Maßnahmen ergänzt werden. Ausgehend von den Emissionen im Verkehrssektor und möglichen Minderungen schlägt das Kapitel den Bogen zu Optionen der Anpassung an den Klimawandel, die ausführlich und konkret dargestellt werden. Besonders betrachtet werden die mannigfaltigen Gefahren der Rückkopplung sowie die vielfältigen Wechselwirungen mit anderen Themengebieten und Sektoren.

Editorial: Virtualität und E-Learning

Directory of Open Access Journals (Sweden)

Horst Dichanz

2001-04-01

Full Text Available Wer Anfang April den Weltkongress des ICDE in Düsseldorf besuchte, der unter dem Titel veranstaltet wurde, war von der Fülle der Veranstaltungen überrascht, die sich auf die eine oder andere Weise aus unterschiedlichster Sicht mit Fragen von Virtuellen Lernwelten und den Möglichkeiten des E-Learning befassten. Mindestens ebenso schwer zu überblicken waren die zahlreichen Produkte, die von Firmen aus zahlreichen Ländern für Zwecke der Gestaltung von virtuellen Lernwelten und zur Durchführung von E-Learning-Veranstaltungen angeboten wurden. Diese E-Learning-Produkte reichten von simplen Datenbanken verschiedenster Fächer über Lern- und Kommunikationsplattformen bis hin zu komplexen Oberflächen oder Rahmenprogrammen zur Konstruktion eigener Lernsoftware. - Über solide, methodisch nachprüfbare Erfolgsuntersuchungen konnten allerdings nur wenige berichten. Die Szene im Internet, das man auf «Virtualiät» und «E-Learning» durchforstet, ist kaum anders: Dutzende von Firmen und Instituten bieten «E-Learning»-Produkte an. Ohne im Detail zu beschreiben, was an ihrem Produkt nun «E-Learning» ist. In den meisten Fällen stellt sich heraus, dass es sich dabei um elektronisch gespeicherten, bearbeitbaren und/oder gewinnbaren Lernstoff handelt, dessen Lernnutzen zweifelsfrei unterstellt wird. Ein zweiter Schwachpunkt: Was konkret unter «Lernen» mithilfe elektronischer Medien gemeint ist, was sich die Produzenten, Autoren u.ä. darunter vorstellen, wird noch seltener thematisiert. Gleichwohl ist der Markt in allen Bildungsbereichen riesig, er wird als expandierend eingeschätzt, in Verbindung mit den elektronischen Medien wird gelegentlich sogar der Bildungsmarkt als ein Wachstumsmarkt charakterisiert. Viel Grund zu Optimismus, noch mehr Grund zu detaillierten Rückfragen! Doch sind Arbeiten, genaue Untersuchungen zu den Komplexen «Virtualität» und «E-Learning» noch mit der Lupe zu suchen. Es gehört zweifellos zu den Aufgaben einer

KRISENZUSTÄNDE UND ANWENDUNG VON ZWANGSMASSNAHMEN IN DER PSYCHIATRIE

Directory of Open Access Journals (Sweden)

Vesna Šendula Jengić

2017-01-01

Full Text Available In der Arbeit wird über die Phänomene der Aggressivität und Gewalt bei Menschen diskutiert, wobei man besonderen Wert auf die Personen mit seelischen Störungen legt. Krisenzustände und Gewaltverhalten gibt es nicht nur in der Psychiatrie. Es kann immer zu einem solchem Zustand und Verhalten kommen und jeder kann unter bestimmten Umständen sowohl Opfer als auch Täter sein. Multikausalität und Komplexität sowie auch individuelle Umstände und situationsbezogene Faktoren, welche zum Gewaltverhalten führen können, haben nur geringen Prognosekraft. Statistische Indikatoren andererseits können falsch positive und falsch negative Ergebnisse verbergen, wobei ein Fehler in der Einschätzung das Risiko zum Erscheinen eines Verhaltens drastisch erhöhen oder zum unrechtfertigten Entziehung der Freiheit führen kann. Zwangsmaβnahmen in der Psychiatrie sind nur ausnahmsweise anzuwenden, und zwar, wenn ein gefährliches Verhalten direkt das Leben und die Gesundheit einer Person oder einer Umgebung gefährdet. Darüber hinaus ist die Dauer von Zwangsmaβnahmen auch beschränkt. Die Gesetzesregulative, insbesondere das Gesetz über den Schutz von Personen mit seelischen Störungen (Amtsblatt der Republik Kroatien Nr. 76/2014 und die Ordnung über die Arten und die Weise der Anwendung von Zwangsmaβnahmen gegenüber den Personen mit schwierigen seelischen Störungen (Amtsblatt der Republik Kroatien Nr. 16/2015, dient als zusätzlicher Schutz der Rechte dieser Patientengruppe und schreibt die Arten und die Weise der Anwendung von Zwangsmaβnahmen sowie auch die Vorgehensweise. Zusätzliche Richtlinien und Vorgehensstrategien wurden auch von den Gesellschaften für Psychiatrie gegeben. In der Arbeit wird betont, dass bessere Bedingungen, Infrastruktur und Arbeitskräfte sowie auch ständige Entwicklung und Bewertung der Arbeitsqualität in der Psychiatrie erforderlich sind. Abschlieβend werden Standards und ethische Fragen in Betracht gezogen, wie

Zustand und Perspektiven der Kapitalmarktfinanzierung in Deutschland

DEFF Research Database (Denmark)

Beck, Thorsten; Kaserer, Christoph; Rapp, Marc Steffen

2016-01-01

Die Autoren haben sich im Rahmen des durch das Bundesministerium für Wirtschaft und Energie (BMWi) in Auftrag gegebenen Forschungsprojekts „Beteiligungs- und Kapitalmarktfinanzierung im deutschen Finanzsystem: Zustand und Entwicklungsperspektiven“ (Dienstleistungsprojekt I C 4 -27/14) mit dem Zus...

Alexander Kratochvil. Aufbruch und Rückkehr: Ukrainische und tschechische Prosa im Zeichen der Postmoderne.

Directory of Open Access Journals (Sweden)

Marko Pavlyshyn

2015-01-01

Full Text Available Alexander Kratochvil. Aufbruch und Rückkehr: Ukrainische und tschechische Prosa im Zeichen der Postmoderne. [Venturing Forth and Coming Back: Ukrainian and Czech Prose in the Context of Postmodernity.] Berlin: Kulturverlag Kadmos, 2013. 311 pp. Bibliography. Index. Paper.