Effect of Asymmetric Layout of IGBT Modules on Reliability of Power Inverters in Motor Drive System

DEFF Research Database (Denmark)

Choi, Uimin; Vernica, Ionut; Blaabjerg, Frede

2018-01-01

of inverters are limited by the most stressed devices. However, generally common data is provided for all devices and this may cause improper design of the inverters in terms of power rating and lifetime. In this paper, the effect of an asymmetric layout of IGBT modules on the reliability of power inverters......An IGBT module has typically multiple power devices for some technical and cost advantages. This kind of configurations could have an asymmetric layout, which may lead to different thermal loadings and thereby lifetime difference of the power devices. Therefore, both the power rating and lifetime...... is studied based on a 3-phase motor drive application with a 600 V, 30 A, 3-phase transfer molded IGBT module. The thermal impedances of 6 IGBTs are investigated and its effect on the thermal loadings of power devices is studied under the given mission profile. Finally, their lifetimes are estimated...

Comprehensive Investigation on Current Imbalance among Parallel Chips inside MW-Scale IGBT Power Modules

DEFF Research Database (Denmark)

Wu, Rui; Smirnova, Liudmila; Wang, Huai

2015-01-01

With the demands for increasing the power rating and improving reliability level of the high power IGBT modules, there are further needs of understanding how to achieve stable paralleling and identical current sharing between the chips. This paper investigates the stray parameters imbalance among...... parallel chips inside the 1.7 kV/1 kA high power IGBT modules at different frequencies by Ansys Q3D parastics extractor. The resulted current imbalance is further confirmed by experimental measurement....

Online Vce measurement method for wear-out monitoring of high power IGBT modules

DEFF Research Database (Denmark)

Beczkowski, Szymon; Ghimire, Pramod; de Vega, Angel Ruiz

2013-01-01

A simple Vce online monitoring circuit is presented in this paper. It allows an accurate wear out prediction of IGBT modules, in high-power applications, during normal converter operation. Bipolar measurement allows monitoring of both IGBT and antiparallel diode. The circuit uses two serial...... offset due to diodes' forward voltage temperature dependency. Using four diodes one can monitor voltages on all power devices in a converter leg....

Effect of Junction Temperature Swing Durations on a Lifetime of a Transfer Molded IGBT Module

DEFF Research Database (Denmark)

Choi, Uimin; Blaabjerg, Frede; Jorgensen, Soren

2016-01-01

results under 6 different conditions and it may improve a lifetime model for lifetime prediction of IGBT modules under various mission profiles of converters. The power cycling tests are performed by an advanced power cycling test setup which enables tested modules to be operated under more realistic......In this paper, the effect of junction temperature swing duration on the lifetime of a transfer molded Intelligent Power IGBT Module is studied and a relevant lifetime factor is modeled. A temperature swing duration dependent lifetime factor is defined based on 38 accelerated power cycling test...

Analytical and Experimental Investigation on A Dynamic Thermo-Sensitive Electrical Parameter with Maximum dI_C/dt during Turn-off for High Power Trench Gate/Field-Stop IGBT Modules

DEFF Research Database (Denmark)

Chen, Yuxiang; Luo, Haoze; Li, Wuhua

2017-01-01

collector current during turn-off process is developed in terms of the behavior characteristics of the inside storage carriers. Then, the inherent linear relationship between the maximum collector current falling rate dI{C}/dt and junction temperature T {j} is demonstrated and investigated. Fortunately......, benefitting from the presence of the intrinsic parasitic inductance L{rm eE} between the Kelvin and power emitters of IGBT modules, the maximum dI{C}/dt can be easily measured to validate the theoretical analysis. Consequently, the maximum dI{C}/dt during turn-off process is a promising DTSEP for IGBT module...

Investigation on the Short-Circuit Behavior of an Aged IGBT Module Through a 6 kA/1.1 kV Non-Destructive Testing Equipment

DEFF Research Database (Denmark)

Wu, Rui; Smirnova, Liudmila; Iannuzzo, Francesco

2014-01-01

This paper describes the design and development of a 6 kA/1.1 kV non-destructive testing system, which aims for short circuit testing of high-power IGBT modules. An ultralow stray inductance of 37 nH is achieved in the implementation of the tester. An 100 MHz FPGA supervising unit enables 10 ns...

An IGBT Driven Slotted Beam Pipe Kicker for SPEAR III Injection

International Nuclear Information System (INIS)

2002-01-01

The SPEAR III injection kicker system is composed of three kicker magnets, K1, K2, and K3. These magnets, along with the power modulators to drive them constitute an injection system which will be used to deflect an incoming electron beam with an energy of 3.3 GeV by an angle of 2.5 mrad for K1 and K3, and 1 mrad for K2. The pulse shape of the magnetic field in the three magnets must be matched in order to preserve a closed orbit. The pulse duration is required to be less than 780 ns, with rise and fall times of less than 375 ns, and a pulse repetition frequency of 10 Hz. The aperture of all three magnets is 60 x 34 mm in an 8 inch vacuum vessel. The magnetic length is 1.2 m for K1 and K3, and 0.6 m for K2 [1]. The magnet design employs a slotted beam pipe which is shorted at one end. A solid state IGBT based, induction type of modulator drives the magnets. Modulators for K1 and K3 consist of eight 4.5 kV, 600 A IGBTs, and eight Finemet magnet cores with four 22.5 Ohm output cables to drive 2381 A into the magnets. The modulator for K2 uses four IGBTs and cores, and 8 output cables to produce a 2619 A pulse. Cables of length greater than one half the pulse width must be used in order to avoid reflections from the shorted magnet. The design charge voltage for the modulators is 20 kV for K1 and K3. This paper describes the magnet and modulator design, as and presents test data from a prototype system

Non-Destructive Investigation on Short Circuit Capability of Wind-Turbine-Scale IGBT Power Modules

DEFF Research Database (Denmark)

Wu, Rui; Iannuzzo, Francesco; Wang, Huai

2014-01-01

This paper presents a comprehensive investigation on the short circuit capability of wind-turbine-scale IGBT power modules by means of a 6 kA/1.1 kV non-destructive testing system. A Field Programmable Gate Array (FPGA) supervising unit is adpoted to achieve an accurate time control for short...... circuit test, which enables to define the driving signals with an accuracy of 10 ns. Thanks to the capability and the effectiveness of the constructed setup, oscillations appearing during short circuits of the new-generation 1.7 kV/1 kA IGBT power modules have been evidenced and characterized under...

Fuzzy Logic Controlled Solar Module for Driving Three- Phase Induction Motor

Science.gov (United States)

Afiqah Zainal, Nurul; Sooi Tat, Chan; Ajisman

2016-02-01

Renewable energy produced by solar module gives advantages for generated three- phase induction motor in remote area. But, solar module's ou tput is uncertain and complex. Fuzzy logic controller is one of controllers that can handle non-linear system and maximum power of solar module. Fuzzy logic controller used for Maximum Power Point Tracking (MPPT) technique to control Pulse-Width Modulation (PWM) for switching power electronics circuit. DC-DC boost converter used to boost up photovoltaic voltage to desired output and supply voltage source inverter which controlled by three-phase PWM generated by microcontroller. IGBT switched Voltage source inverter (VSI) produced alternating current (AC) voltage from direct current (DC) source to control speed of three-phase induction motor from boost converter output. Results showed that, the output power of solar module is optimized and controlled by using fuzzy logic controller. Besides that, the three-phase induction motor can be drive and control using VSI switching by the PWM signal generated by the fuzzy logic controller. This concluded that the non-linear system can be controlled and used in driving three-phase induction motor.

Comparative performance analysis of Thyristor and IGBT based ...

African Journals Online (AJOL)

The paper systematically investigates and compares the characteristics of a variable voltage fed induction motor drive for two different types of soft starters; one based on IGBT and another based on Thyristor. Experimental validation is done using ... Keywords: Variable speed electric drives, Soft starter, Thyristor, IGBT ...

An online Vce measurement and temperature estimation method for high power IGBT module in normal PWM operation

DEFF Research Database (Denmark)

Ghimire, Pramod; de Vega, Angel Ruiz; Beczkowski, Szymon

2014-01-01

An on-state collector-emitter voltage (Vce) measurement and thereby an estimation of average temperature in space for high power IGBT module is presented while power converter is in operation. The proposed measurement circuit is able to measure both high and low side IGBT and anti parallel diode...

A 120kV IGBT modulator for driving a Pierce electron gun

International Nuclear Information System (INIS)

Earley, Lawrence M.; Brown, Richard W.; Carlson, Randolph L.; Ferguson, Patrick; Haynes, William B.; Kirbie, Hugh C.; Russell, Steven J.; Sigler, Floyd E.; Smirnova, Evgenya I.; Wheat, Robert M. Jr.

2004-01-01

An IGBT modulator has been developed to drive a 120 kV, 23 A Pierce electron gun. The modulator is capable of producing pulses up to 10 μs in width at repetition rates up to 10Hz with no active reset. The pulse rise time on the electron gun will be approximately 2 μs and the remaining 8 μs of flattop is tuned to have a ripple of less than 1 percent rms. The modulator technology was developed from a previous 50 kV prototype. The modulator consists of six boards, each with one EUPEC IGBT that drives a single common step-up transformer wound on METGLAS 2605SC cores. The six transformer cores share a common bi-filar output secondary winding. The modulator uses a fiber optic trigger system and has a high voltage cable output with an epoxy receptacle on the oil end and a ceramic receptacle on the vacuum end. The 120 kV electron gun was manufactured by MDS Co. and will be used to generate sheet electron beams from the standard pencil beam produced by the Pierce electron gun.

A 3D Lumped Thermal Network Model for Long-term Load Profiles Analysis in High Power IGBT Modules

DEFF Research Database (Denmark)

Bahman, Amir Sajjad; Ma, Ke; Ghimire, Pramod

2016-01-01

)-based simulation is another method which is often used to analyze the steady-state thermal distribution of IGBT modules, but it is not possible to be used for long-term analysis of load profiles of power converter, which is needed for reliability assessments and better thermal design. This paper proposes a novel...... enables both accurate and fast temperature estimation of high power IGBT modules in the real loading conditions of the converter; meanwhile the critical details of the thermal dynamics and thermal distribution are also maintained. The proposed thermal model is verified by both FEM simulation......The conventional RC lumped thermal networks are widely used to estimate the temperature of power devices, but they are lack of accuracy in addressing detailed thermal behaviors/couplings in different locations and layers of the high power IGBT modules. On the other hand, Finite Element (FE...

Redesign of the SNS Modulator H-Bridge for Utilization of Press-Pack IGBTs

Energy Technology Data Exchange (ETDEWEB)

Kemp, Mark A.; Burkhart, Craig; /SLAC; Anderson, David E.; /Oak Ridge

2008-09-25

The power conversion group at SLAC is currently redesigning the H-bridge switch plates of the High Voltage Converter Modulators at the Spallation Neutron Source. This integral part to the modulator operation has been indentified as a source of several modulator faults and potentially limits reliability with pulse width modulation operation. This paper is a presentation of the design and implementation of a redesigned switch plate based upon press-pack IGBTs.

Fuzzy Logic Controlled Solar Module for Driving Three- Phase Induction Motor

International Nuclear Information System (INIS)

Zainal, Nurul Afiqah; Tat, Chan Sooi; Ajisman

2016-01-01

Renewable energy produced by solar module gives advantages for generated three- phase induction motor in remote area. But, solar module's output is uncertain and complex. Fuzzy logic controller is one of controllers that can handle non-linear system and maximum power of solar module. Fuzzy logic controller used for Maximum Power Point Tracking (MPPT) technique to control Pulse-Width Modulation (PWM) for switching power electronics circuit. DC-DC boost converter used to boost up photovoltaic voltage to desired output and supply voltage source inverter which controlled by three-phase PWM generated by microcontroller. IGBT switched Voltage source inverter (VSI) produced alternating current (AC) voltage from direct current (DC) source to control speed of three-phase induction motor from boost converter output. Results showed that, the output power of solar module is optimized and controlled by using fuzzy logic controller. Besides that, the three-phase induction motor can be drive and control using VSI switching by the PWM signal generated by the fuzzy logic controller. This concluded that the non-linear system can be controlled and used in driving three-phase induction motor. (paper)

Effect of Asymmetric Layout of IGBT Modules on Reliability of Power Inverters in Motor Drive System

DEFF Research Database (Denmark)

Choi, Uimin; Vernica, Ionut; Blaabjerg, Frede

2018-01-01

An IGBT module has typically multiple power devices for some technical and cost advantages. This kind of configurations could have an asymmetric layout, which may lead to different thermal loadings and thereby lifetime difference of the power devices. Therefore, both the power rating and lifetime...... of inverters are limited by the most stressed devices. However, generally common data is provided for all devices and this may cause improper design of the inverters in terms of power rating and lifetime. In this paper, the effect of an asymmetric layout of IGBT modules on the reliability of power inverters...

Vce-based methods for temperature estimation of high power IGBT modules during power cycling - A comparison

DEFF Research Database (Denmark)

Amoiridis, Anastasios; Anurag, Anup; Ghimire, Pramod

2015-01-01

. This experimental work evaluates the validity and accuracy of two Vce based methods applied on high power IGBT modules during power cycling tests. The first method estimates the chip temperature when low sense current is applied and the second method when normal load current is present. Finally, a correction factor......Temperature estimation is of great importance for performance and reliability of IGBT power modules in converter operation as well as in active power cycling tests. It is common to be estimated through Thermo-Sensitive Electrical Parameters such as the forward voltage drop (Vce) of the chip...

A temperature dependent simple spice based modeling platform for power IGBT modules

NARCIS (Netherlands)

Sfakianakis, G.; Nawaz, M.; Chimento, F.

2014-01-01

This paper deals with the development of a PSpice based temperature dependent modelling platform for the evaluation of silicon based IGBT power modules. The developed device modelling platform is intended to be used for the design and assessment of converter valves/cells for potential high power

Test setup for accelerated test of high power IGBT modules with online monitoring of Vce and Vf voltage during converter operation

DEFF Research Database (Denmark)

de Vega, Angel Ruiz; Ghimire, Pramod; Pedersen, Kristian Bonderup

2014-01-01

Several accelerated test methods exist in order to study the failures mechanisms of the high power IGBT modules like temperature cycling test or power cycles based on DC current pulses. The main drawback is that the test conditions do not represent the real performance and stress conditions...... of the device in real application. The hypothesis is that ageing of power modules closer to real environment including cooling system, full dc-link voltage and continuous PWM operation could lead to more accurate study of failure mechanism. A new type of test setup is proposed, which can create different real...... load conditions like in the field. Furthermore, collector-emitter voltage (Vce) has been used as indicator of the wear-out of the high power IGBT module. The innovative monitoring system implemented in the test setup is capable of measure the Vce and forward voltage of the antiparallel diode (Vf...

Modeling of Short-Circuit-Related Thermal Stress in Aged IGBT Modules

DEFF Research Database (Denmark)

Bahman, Amir Sajjad; Iannuzzo, Francesco; Uhrenfeldt, Christian

2017-01-01

In this paper, the thermal stress on bond wires of aged IGBT modules under short-circuit conditions has been studied with respect to different solder delamination levels. To ensure repeatable test conditions, ad-hoc DBC (direct bond copper) samples with delaminated solder layers have been purposely...... in the surface temperature distribution, which confirms the hypothesis that short-circuit events produce significantly uneven stresses on bond wires....

Prediction of Short-Circuit-Related Thermal Stress in Aged IGBT Modules

DEFF Research Database (Denmark)

Bahman, Amir Sajjad; Iannuzzo, Francesco; Uhrenfeldt, Christian

2016-01-01

In this paper, the thermal stress on bond wires of aged IGBT modules under short-circuit conditions has been studied with respect to different solder delamination levels. To ensure repeatable test conditions, ad-hoc DBC (direct bond copper) samples with delaminated solder layers have been purposely...... in the surface temperature distribution which confirms the hypothesis that short-circuit events produce significantly uneven stresses on bond wires....

An Icepak-PSpice Co-Simulation Method to Study the Impact of Bond Wires Fatigue on the Current and Temperature Distribution of IGBT Modules under Short-Circuit

DEFF Research Database (Denmark)

Wu, Rui; Iannuzzo, Francesco; Wang, Huai

2014-01-01

Bond wires fatigue is one of the dominant failure mechanisms of IGBT modules. Prior-art research mainly focuses on its impact on the end-of-life failure, while its effect on the short-circuit capability of IGBT modules is still an open issue. This paper proposes a new electro-thermal simulation...... approach enabling analyze the impact of the bond wires fatigue on the current and temperature distribution on IGBT chip surface under short-circuit. It is based on an Icepack-PSpice co-simulation by taking the advantage of both a finite element thermal model and an advanced PSpice-based multi-cell IGBT...

Robustness of MW-Level IGBT modules against gate oscillations under short circuit events

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Wu, Rui; Iannuzzo, Francesco

2015-01-01

The susceptibility of MW-level IGBT power modules to critical gate voltage oscillations during short circuit events has been evidenced experimentally. This paper proposes a sensitivity analysis method to better understand the oscillating behavior dependence on different operating conditions (i...... the oscillation phenomenon, as well as to further improve the device performance during short circuit....

Modelling and Analysis of Proximity Effect in IGBT Fuses

DEFF Research Database (Denmark)

Iov, Florin; Blaabjerg, Frede; Rasmussen, Henrik

2005-01-01

The demand for protection of power electronic applications has during the last couple of years increased regarding the high-power IGBT modules. The consequences of electrical faults can be severe in special cases; not only on the equipment but also to people, if safety principles are not applied....... Even with an active protection, a high power IGBT still has a risk of exhibiting a violent rupture in the case of a fault if e.g. IGBT fuses are not protecting it. By introducing fuses into voltage source converters a better protection of IGBT's can be achieved. However, skin and proximity effects...

Modulator R and D for the NLC

International Nuclear Information System (INIS)

Koontz, Roland F

2000-01-01

Planning for the Next Linear Collider (NLC) continues at SLAC, Fermilab, and Lawrence Livermore Lab with help from many other members of the high energy physics community. The frequency of the proposed accelerator is X-band. An X-band klystron developed at SLAC has produced 75 MW peak power capable of driving the NLC. Modulator development to drive this klystron is proceeding on two interconnected paths, one using IGBT (Insulated Gate Bipolar Transistors) switched induction cores to drive multiple (8) klystrons, and the second path supported by SBIR grants looking at direct IGBT switching or IGBT switches in conjunction with optimized conventional pulse transformers. Conventional thyratron modulators are not yet out of the picture as the long term reliability of IGBT's in pulse service must still be proved. This paper reviews some of the modulator designs current in development

Three level MV converter using series connected IGBT's

DEFF Research Database (Denmark)

Munk-Nielsen, Stig; Vaerens, M.C.P.; Sundvall, J.

2009-01-01

A simple method of serial connecting IGBT's is applied and standard low voltage IGBT modules are used in the MV test inverter to evaluate the method. The dc link voltage is 2.4 kV and the RMS output line to line voltage is 1.7kV. The method works and test experiences are presented in paper....

Validation of Lifetime Prediction of IGBT Modules Based on Linear Damage Accumulation by Means of Superimposed Power Cycling Tests

DEFF Research Database (Denmark)

Choi, Ui-Min; Ma, Ke; Blaabjerg, Frede

2018-01-01

In this paper, the lifetime prediction of power device modules based on the linear damage accumulation is studied in conjunction with simple mission profiles of converters. Superimposed power cycling conditions, which are called simple mission profiles in this paper, are made based on a lifetime ...... prediction of IGBT modules under power converter applications.......In this paper, the lifetime prediction of power device modules based on the linear damage accumulation is studied in conjunction with simple mission profiles of converters. Superimposed power cycling conditions, which are called simple mission profiles in this paper, are made based on a lifetime...... model in respect to junction temperature swing duration. This model has been built based on 39 power cycling test results of 600-V 30-A three-phase-molded IGBT modules. Six tests are performed under three superimposed power cycling conditions using an advanced power cycling test setup. The experimental...

General 3D Lumped Thermal Model with Various Boundary Conditions for High Power IGBT Modules

DEFF Research Database (Denmark)

Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

2016-01-01

Accurate thermal dynamics modeling of high power Insulated Gate Bipolar Transistor (IGBT) modules is important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated...... thermal behaviors in the IGBTs. In this paper, a new three-dimensional (3D) lumped thermal model is proposed, which can easily be characterized from Finite Element Methods (FEM) based simulation and acquire the thermal distribution in critical points. Meanwhile the boundary conditions including...... the cooling system and power losses are modeled in the 3D thermal model, which can be adapted to different real field applications of power electronic converters. The accuracy of the proposed thermal model is verified by experimental results....

Round busbar concept for 30 nH, 1.7 kV, 10 kA IGBT non-destructive short-circuit tester

DEFF Research Database (Denmark)

Smirnova, Liudmila; Pyrhönen, Juha; Iannuzzo, Francesco

2014-01-01

Design of a Non-Destructive Test (NDT) set-up for short-circuit tests of 1.7 kV, 1 kA IGBT modules is discussed in this paper. The test set-up allows achieving short-circuit current up to 10 kA. The important objective during the design of the test set-up is to minimize the parasitic inductance...

The Impact of Mission Profile Models on the Predicted Lifetime of IGBT Modules in the Modular Multilevel Converter

DEFF Research Database (Denmark)

Zhang, Yi; Wang, Huai; Wang, Zhongxu

2017-01-01

and electrical power modeling methods on the estimated lifetime of IGBT modules in an MMC for offshore wind power application. In a 30 MW MMC case study, an annual wind speed profile with a resolution of 1 s/data, 10 minute/data, and 1 hour/data are considered, respectively. A method to re-generate higher......The reliability aspect study of Modular Multilevel Converter (MMC) is of great interest in industry applications, such as offshore wind. Lifetime prediction of key components is an important tool to design MMC with fulfilled reliability specifications. While many efforts have been made...... to the lifetime prediction of IGBT modules in renewable energy applications by considering long-term varying operation conditions (i.e., mission profile), the justifications of using the associated mission profiles are still missed. This paper investigates the impact of mission profile data resolutions...

Characterization of power IGBTs under pulsed power conditions

Energy Technology Data Exchange (ETDEWEB)

Dale, Gregory E [Los Alamos National Laboratory; Vangordon, James [UNIV OF MISSOURI; Kovaleski, Scott [UNIV OF MISSOURI

2009-01-01

The power insulated gate bipolar transistor (IGBT) is used in many types of applications. Although the use of the power IGBT has been well characterized for many continuous operation power electronics applications, little published information is available regarding the performance of a given IGBT under pulsed power conditions. Additionally, component libraries in circuit simulation software packages have a finite number of IGBTs. This paper presents a process for characterizing the performance of a given power IGBT under pulsed power conditions. Specifically, signals up to 3.5 kV and 1 kA with 1-10 {micro}s pulse widths have been applied to a Powerex QIS4506001 IGBT. This process utilizes least squares curve fitting techniques with collected data to determine values for a set of modeling parameters. These parameters were used in the Oziemkiewicz implementation of the Hefner model for the IGBT that is utilized in some circuit simulation software packages. After the nominal parameter values are determined, they can be inserted into the Oziemkiewicz implementation to simulate a given IGBT.

Thermal Simulation of Switching Pulses in an Insulated Gate Bipolar Transistor (IGBT) Power Module

Science.gov (United States)

2015-02-01

executed with SolidWorks Flow Simulation , a computational fluid-dynamics code. The graph in Fig. 2 shows the timing and amplitudes of power pulses...defined a convective flow of air perpendicular to the bottom surface of the mounting plate, with a velocity of 10 ft/s. The thermal simulations were...Thermal Simulation of Switching Pulses in an Insulated Gate Bipolar Transistor (IGBT) Power Module by Gregory K Ovrebo ARL-TR-7210

Advanced power cycler with intelligent monitoring strategy of IGBT module under test

DEFF Research Database (Denmark)

Choi, U. M.; Blaabjerg, F.; Iannuzzo, F.

2017-01-01

and diode, which for the wear-out condition monitoring are presented. This advanced power cycler allows to perform power cycling test cost-effectively under conditions close to real power converter applications. In addition, an intelligent monitoring strategy for the separation of package-related wear......-out failure mechanisms has been proposed. By means of the proposed method, the wear-out failure mechanisms of an IGBT module can be separated without any additional efforts during the power cycling tests. The validity and effectiveness of the proposed monitoring strategy are also verified by experiments....

High current high accuracy IGBT pulse generator

International Nuclear Information System (INIS)

Nesterov, V.V.; Donaldson, A.R.

1995-05-01

A solid state pulse generator capable of delivering high current triangular or trapezoidal pulses into an inductive load has been developed at SLAC. Energy stored in a capacitor bank of the pulse generator is switched to the load through a pair of insulated gate bipolar transistors (IGBT). The circuit can then recover the remaining energy and transfer it back to the capacitor bank without reversing the capacitor voltage. A third IGBT device is employed to control the initial charge to the capacitor bank, a command charging technique, and to compensate for pulse to pulse power losses. The rack mounted pulse generator contains a 525 μF capacitor bank. It can deliver 500 A at 900V into inductive loads up to 3 mH. The current amplitude and discharge time are controlled to 0.02% accuracy by a precision controller through the SLAC central computer system. This pulse generator drives a series pair of extraction dipoles

IGBT Dynamic Loss Reduction through Device Level Soft Switching

Directory of Open Access Journals (Sweden)

Lan Ma

2018-05-01

Full Text Available Due to its low conduction loss, hence high current ratings, as well as low cost, Silicon Insulated Gate Bipolar Transistor (Si IGBT is widely used in high power applications. However, its switching frequency is generally low because of relatively large switching losses. Silicon carbide Metal-Oxide-Semiconductor Field-Effect Transistor (SiC MOSFET is much more superior due to their fast switching speed, which is determined by the internal parasitic capacitance instead of the stored charges, like the IGBT. By the combination of SiC MOSFET and Si IGBT, this paper presents a novel series hybrid switching method to achieve IGBT’s dynamic switching loss reduction by switching under Zero Voltage Hard Current (ZVHC turn-on and Zero Current Hard Voltage (ZCHV turn-off conditions. Both simulation and experimental results of IGBT are carried out, which shows that the soft switching of IGBT has been achieved both in turn-on and turn-off period. Thus 90% turn-on loss and 57% turn-off loss are reduced. Two different IGBTs’ test results are also provided to study the modulation parameter’s effect on the turn-off switching loss. Furthermore, with the consideration of voltage and current transient states, a new soft switching classification is proposed. At last, another improved modulation and Highly Efficient and Reliable Inverter Concept (HERIC inverter are given to validate the effectiveness of the device level hybrid soft switching method application.

Reliability of IGBT-based power devices in the viewpoint of applications in future power supply systems

International Nuclear Information System (INIS)

Lutz, J.

2011-01-01

IGBT-based high-voltage power devices will be key components for future renewable energy base of the society. Windmills in the range up to 10 MW use converters with IGBTs. HVDC systems with IGBT-based voltage source converters have the advantage of a lower level of harmonics, less efforts for filters and more possibilities for control. The power devices need a lifetime expectation of several ten years. The lifetime is determined by the reliability of the packaging technology. IGBTs are offered packaged in presspacks and modules. The presentation will have the focus on IGBT high power modules. Accelerated power cycling tests for to determine the end-of-life at given conditions and their results are shown. models to calculate the lifetime, and actual work in research for systems with increased reliability.

A Lumped Thermal Model Including Thermal Coupling and Thermal Boundary Conditions for High Power IGBT Modules

DEFF Research Database (Denmark)

Bahman, Amir Sajjad; Ma, Ke; Blaabjerg, Frede

2018-01-01

Detailed thermal dynamics of high power IGBT modules are important information for the reliability analysis and thermal design of power electronic systems. However, the existing thermal models have their limits to correctly predict these complicated thermal behavior in the IGBTs: The typically used...... thermal model based on one-dimensional RC lumps have limits to provide temperature distributions inside the device, moreover some variable factors in the real-field applications like the cooling and heating conditions of the converter cannot be adapted. On the other hand, the more advanced three......-dimensional thermal models based on Finite Element Method (FEM) need massive computations, which make the long-term thermal dynamics difficult to calculate. In this paper, a new lumped three-dimensional thermal model is proposed, which can be easily characterized from FEM simulations and can acquire the critical...

Current Sharing inside a High Power IGBT Module at the Negative Temperature Coefficient Operating Region

CERN Document Server

AUTHOR|(CDS)2084596; Papastergiou, Konstantinos; Bongiorno, M; Thiringer, T

2016-01-01

This work investigates the current sharing effect of a high power Soft Punch Through IGBT module in the Negative Temperature Coefficient region. The unbalanced current sharing between two of the substrates is demonstrated for different current and temperature levels and its impact on the thermal stressing of the device is evaluated. The results indicate that the current asymmetry does not lead to a significant thermal stressing unbalance between the substrates.

A Temperature-Dependent Thermal Model of IGBT Modules Suitable for Circuit-Level Simulations

DEFF Research Database (Denmark)

Wu, Rui; Wang, Huai; Pedersen, Kristian Bonderup

2016-01-01

A basic challenge in the IGBT transient simulation study is to obtain the realistic junction temperature, which demands not only accurate electrical simulations but also precise thermal impedance. This paper proposed a transient thermal model for IGBT junction temperature simulations during short...

Prediction of Bond Wire Fatigue of IGBTs in a PV Inverter Under a Long-Term Operation

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Wang, Huai; Yang, Yongheng

2016-01-01

consumption of bond wires of IGBT modules in a Photovoltaic (PV) inverter. The variations in IGBT parameters (e.g., on-state collector-emitter voltage), lifetime models, and environmental and operational stresses are taken into account in the lifetime prediction. The distribution of the annual lifetime...... consumption is estimated based on a long-term annual stress profile of solar irradiance and ambient temperature. The proposed method enables a more realistic lifetime prediction with a specified confidence level compared to the state-of-the-art approaches. A study case of IGBT modules in a 10 kW three......Bond wire fatigue is one of the dominant failure mechanisms in IGBT modules under cyclic stresses. However, there are still major challenges ahead to achieve a realistic bond wire lifetime prediction in field operation. This paper proposes a Monte Carlo based analysis method to predict the lifetime...

A real time measurement of junction temperature variation in high power IGBT modules for wind power converter application

DEFF Research Database (Denmark)

Ghimire, Pramod; Pedersen, Kristian Bonderup; de Vega, Angel Ruiz

2014-01-01

This paper presents a real time measurement of on-state forward voltage and estimating the junction temperature for a high power IGBT module during a power converter operation. The power converter is realized as it can be used for a wind turbine system. The peak of the junction temperature is dec...

SPT+-IGBT characteristics and optimization

International Nuclear Information System (INIS)

Chu Weili; Zhu Yangjun; Hu Aibin; Zhang Jie

2013-01-01

A novel advanced soft punch through (SPT) IGBT signed as SPT + -IGBT is investigated. Static and dynamic characteristics are simulated based on the 1200 V device structure and adopted technology. Extensive research on the structure optimization of SPT + -IGBT is presented and discussed. Compared with the structure of conventional IGBT, SPT + -IGBT has a much lower collector—emitter saturation voltage and better switching characteristics. Therefore it is very suitable for applications blocking a voltage higher than 3000 V. In addition, due to the improvement of switching speed achieved by using a thinner chip, SPT + -IGBT is also very competitive in 1200 V and 1700 V applications. (semiconductor devices)

Elimination of bus voltage impact on temperature sensitive electrical parameter during turn-on transition for junction temperature estimation of high-power IGBT modules

DEFF Research Database (Denmark)

Luo, Haoze; Iannuzzo, Francesco; Blaabjerg, Frede

2017-01-01

Junction temperature is of great importance to safe operating area of IGBT modules. Various information of the IGBT operating state is reflected on electrical characteristics during turn-on transient. A unified extraction method for internal junction temperature via dynamic thermo......-sensitive electrical parameters (DTSEP) during turn-on transient is proposed. Two DTSEP, turn-on delay time (tdon) and the maximum increasing rate of collector current dic/dt(max), are combined to eliminate the bus voltage impact. Using the inherent emitter-auxiliary inductor LeE in high-power modules, the temperature......-dependent DTSEPs can be converted into a low-voltage and measurable signal. Finally, experiment results are exhibited to verify the effectiveness of proposed method....

Loss Characteristics of 6.5 kV RC-IGBT Applied to a Traction Converter

Directory of Open Access Journals (Sweden)

Xianjin Huang

2017-07-01

Full Text Available 6.5 kV level IGBT (Insulated Gate Bipolar Transistor modules are widely applied in megawatt locomotive (MCUs traction converters, to achieve an upper 3.5 kV DC link, which is beneficial for decreasing power losses and increasing the power density. Reverse Conducting IGBT (RC-IGBT constructs the conventional IGBT function and freewheel diode function in a single chip, which has a greater flow ability in the same package volume. In the same cooling conditions, RC-IGBT allows for a higher operating temperature. In this paper, a mathematic model is developed, referring to the datasheets and measurement data, to study the 6.5 kV/1000 A RC-IGBT switching features. The relationship among the gate desaturated pulse, conducting losses, and recovery losses is discussed. Simulations and tests were carried out to consider the influence of total losses on the different amplitudes and durations of the desaturated pulse. The RC-IGBT traction converter system with gate pulse desaturated control is built, and the simulation and measurements show that the total losses of RC-IGBT with desaturated control decreased comparing to the RC-IGBT without desaturated control or conventional IGBT. Finally, a proportional small power platform is developed, and the test results prove the correction of the theory analysis.

STUDY ON THE OPTIMIZATION OF IGBT THERMAL MANAGEMENT FOR PTC HEATER

Directory of Open Access Journals (Sweden)

J. W. JEONG

2015-12-01

Full Text Available It is essential to optimize HVAC (Heating, Ventilation and Air-Conditioning system for a thermal plant or an electric vehicle since it has a significant effect on the thermal efficiency. PTC (positive temperature coefficient heaters are often used for a heating system and the power module of the PTC heaters, IGBT (insulated gate bipolar mode transistor, requires thermal management. In this study, in order to maximize the cooling performance for IGBT, a novel method that uses forced convection inside the HVAC duct with heat sinks was developed. In addition, heat sinks were optimized in terms of IGBT junction temperature and heat sink weight by 3-dimensional CFD (Computational Fluid Dynamics simulation. The results show that the junction temperature of IGBT for 5.6kW PTC heater can be maintained at about 335K.

A review on real time physical measurement techniques and their attempt to predict wear-out status of IGBT

DEFF Research Database (Denmark)

Ghimire, Pramod; Beczkowski, Szymon; Munk-Nielsen, Stig

2013-01-01

Insulated Gate Bipolar Transistors (IGBTs) are key component in power converters. Reliability of power converters depend on wear-out process of power modules. A physical parameter such as the on-state collector-emitter voltage (Vce) shows the status of degradation of the IGBT after a certain cycles...... of difficulties in the measurement, the offline and online Vce measurement topologies are implemented to study the reliability of the power converters. This paper presents a review in wear-out prediction methods of IGBT power modules and freewheeling diodes based on the real time Vce measurement. The measurement...

Evidence of Gate Voltage Oscillations during Short Circuit of Commercial 1.7 kV/ 1 kA IGBT Power Modules

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Wu, Rui; Iannuzzo, Francesco

2015-01-01

This paper analyzes the evidence of critical gate voltage oscillations in 1.7 kV/1 kA Insulated-Gate Bipolar Transistor (IGBT) power modules under short circuit conditions. A 6 kA/1.1 kV Non-Destructive Test (NDT) set up for repeatable short circuit tests has been built with a 40 nH stray inducta...

Glass-melting using an IGBT full-bridge resonant converter

International Nuclear Information System (INIS)

Pacheco S, J.O.; Gutierrez O, E.; Benitez R, J.S.; Martinez V, J.; Lopez C, R.

1999-01-01

This work describes the design implementation and application of a full-bridge IGBT resonant converter used to obtain glass melting. The design procedure is discussed and complete converter schematics are provided, including drivers and control circuits. A brief review of the glass properties is given, and some coupling parameters of the induction furnace are also described. A very special provision is made to the coupling charge transformer and the heat induced to the glass itself, first by conduction, followed by direct electromagnetic induction when the glass becomes a conductor. A brief analysis of electromagnetic fields, current density and power induced in the material is given. A very simple method is presented to calculate the power absorbed by the load and therefore the efficiency of the heating process. Several tests are carried out to verify the effectiveness of this method. Finally, this paper describes the design and construction of a 5 k W, 50 k Hz Full-Bridge Resonant Converter (FBRC), based on IGBT transistors and a transformer-capacitor coupled to a thermal load composed of a metal-glass cylinder. For glass makers, the benefits obtained by implementing the melting system with an IGBT-based FRBC resides on the relative simplicity of its design, the low-cost of the components, the energy transfer efficiency, and the robustness of its operation. With a proper scaling, this melting system can be used, for instance, to vitrify hazardous industrial wastes, nuclear waste, and fume ashes from melting plants or combustion systems. (Author)

The IGBT as an element of switch discharge with a linear mode use in capacitor discharge power converters

CERN Document Server

Cravero, J M

1998-01-01

This paper presents an unusual use of IGBT (Insulated Gate Bipolar Transistor) modules in capacitor discharge power supplies to achieve different current pulse shapes. The new power converters are described with an emphasis on the use of the IGBT as a discharge switch or in a linear mode. The difficulties involved in implementing IGBTs in these modes are analysed. IGBT voltage and gate commands are reviewed for these different modes and the control system that is necessary to regulate the magnet current is described. Finally, the future is envisaged with the new trends in this direction.

Research on current sharing of paralleled IGBTs in different DC breaker circuit topologies

Directory of Open Access Journals (Sweden)

Chen Ying

2016-01-01

Full Text Available IGBT modules used in series and parallel to satisfy the requirement in high-power DC circuit breakers are often prone to large-current destruction due to current unbalance between paralleled IGBTs. It is of great importance to identify the current unbalance causes and to find a method optimizing the current sharing of paralleled IGBTs. In this paper the current-sharing influencing factors are discussed and verified by simulation. Two possible circuit topologies used in DC circuit breakers are proposed and simulated to see their performance in current sharing. The results show that one of them can provide us with a simple and effective method to achieve good current balancing in the DC circuit breaker application.

Diagnosis of Intermittent Faults in IGBTs Using the Latent Nestling Method with Hybrid Coloured Petri Nets

Directory of Open Access Journals (Sweden)

Leonardo Rodriguez-Urrego

2015-01-01

Full Text Available This paper presents a fault diagnosis application of the Latent Nestling Method to IGBTs. The paper extends the Latent Nestling Method based in Coloured Petri Nets (CPNs to hybrid systems in such a manner that IGBTs performance can be modeled. CPNs allow for an enhanced capability for synthesis and modeling in contrast to the classical phenomena of combinational state explosion when Finite State Machine methods are applied. We present an IGBT model with different fault modes including those of intermittent nature that can be used advantageously as predictive symptoms within a predictive maintenance strategy. Ageing stress tests have been experimentally applied to the IGBTs modules and intermittent faults are diagnosed as precursors of permanent failures. In addition, ageing is validated with morphological analysis (Scanning Electron Microscopy and semiqualitative analysis (Energy Dispersive Spectrometry.

Fault Detection and Location of IGBT Short-Circuit Failure in Modular Multilevel Converters

Directory of Open Access Journals (Sweden)

Bin Jiang

2018-06-01

Full Text Available A single fault detection and location for Modular Multilevel Converter (MMC is of great significance, as numbers of sub-modules (SMs in MMC are connected in series. In this paper, a novel fault detection and location method is proposed for MMC in terms of the Insulated Gate Bipolar Translator (IGBT short-circuit failure in SM. The characteristics of IGBT short-circuit failures are analyzed, based on which a Differential Comparison Low-Voltage Detection Method (DCLVDM is proposed to detect the short-circuit fault. Lastly, the faulty IGBT is located based on the capacitor voltage of the faulty SM by Continuous Wavelet Transform (CWT. Simulations have been done in the simulation software PSCAD/EMTDC and the results confirm the validity and reliability of the proposed method.

Improving the Short-Circuit Reliability in IGBTs

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Iannuzzo, Francesco; Rahimo, Munaf

2018-01-01

takes place during the IGBT short-circuit, whose time-varying element is the Miller capacitance, which is involved in the amplification mechanism. This hypothesis has been validated through simulations and its mitigation is possible by increasing the electric field at the emitter of the IGBT......In this paper, the oscillation mechanism limiting the ruggedness of IGBTs is investigated through both circuit and device analysis. The work presented here is based on a time-domain approach for two different IGBT cell structures (i.e., trench-gate and planar), illustrating the 2-D effects during...

Research on Single-Phase PWM Converter with Reverse Conducting IGBT Based on Loss Threshold Desaturation Control

Directory of Open Access Journals (Sweden)

Xianjin Huang

2017-11-01

Full Text Available In the application of vehicle power supply and distributed power generation, there are strict requirements for the pulse width modulation (PWM converter regarding power density and reliability. When compared with the conventional insulated gate bipolar transistor (IGBT module, the Reverse Conducting-Insulated Gate Bipolar Transistor (RC-IGBT with the same package has a lower thermal resistance and higher current tolerance. By applying the gate desaturation control, the reverse recovery loss of the RC-IGBT diode may be reduced. In this paper, a loss threshold desaturation control method is studied to improve the output characteristics of the single-phase PWM converter with a low switching frequency. The gate desaturation control characteristics of the RC-IGBT’s diode are studied. A proper current limit is set to avoid the ineffective infliction of the desaturation pulse, while the bridge arm current crosses zero. The expectation of optimized loss decrease is obtained, and the better performance for the RC-IGBTs of the single-phase PWM converter is achieved through the optimized desaturation pulse distribution. Finally, the improved predictive current control algorithm that is applied to the PWM converter with RC-IGBTs is simulated, and is operated and tested on the scaled reduced power platform. The results prove that the gate desaturation control with the improved predictive current algorithm may effectively improve the RC-IGBT’s characteristics, and realize the stable output of the PWM converter.

Comparative assessment of 3.3kV/400A SiC MOSFET and Si IGBT power modules

DEFF Research Database (Denmark)

Ionita, Claudiu; Nawaz, Muhammad; Ilves, Kalle

2017-01-01

In this paper, a comparative evaluation between a commercial 3.3 kV/400 A Si-IGBT and a 3.3 kV/400 A SiC MOSFET power module in half-bridge configuration is presented. With a constant current of 250 A, a lower forward voltage (VDS) drop of 1.6 V is obtained for SiC MOSFET at 300 K compared to Si ...... the pulse duration was increased to 4 μs, where a short-circuit energy of 9.1 J was obtained. The cause of the failure is the thermal runaway leading to a drain-source short....

A Temperature Dependent Lumped-charge Model for Trench FS-IGBT

DEFF Research Database (Denmark)

Duan, Yaoqiang; Kang, Yong; Iannuzzo, Francesco

2018-01-01

Abstract: This paper proposes a temperature dependent lumped-charge model for FS-IGBT. Due to the evolution of the IGBT structure, the existing lumped-charge IGBT model established for NPT-IGBT is not suitable for the simulation of FS-IGBT. This paper extends the lumped-charge IGBT model including...... the field-stop (FS) structure and temperature characteristics. The temperature characteristics of the model are considered for both the bipolar part and unipolar part. In addition, a new PN junction model which can distinguish the collector structure is presented and validated by TCAD simulation. Finally...

IGBT Based DC/DC Converter

Directory of Open Access Journals (Sweden)

M. Akherraz

1997-12-01

Full Text Available This paper presents an in-depth analytical and experimental investigation of an indirect DC-DC converter. The DC-AC conversion is a full bridge based on IGBT power modules, and the AC-DC conversion is done via a high  frequency AC link and a first diode bridge. The AC link, which consists of snubbing capacitors and a variable air-gap transformer, is analytically designed to fulfill Zero Voltage commutation requirement. The proposed converter is simulated using PSPICE and a prototype is designed built and tested in the laboratory. PSPICE simulation and experimental results are presented and compared.

Development of bouncer-type pulse modulator for the ILC

International Nuclear Information System (INIS)

Akemoto, Mitsuo; Honma, Hiroyuki; Nakajima, Hiromitsu; Shidara, Tetsuo; Fukuda, Shigeki

2009-01-01

This paper describes a long-pulse 1.3 GHz klystron modulator that was recently developed for the Superconducting RF Test Facility (STF) at High Energy Accelerator Research Organization (KEK). The modulator has a direct-switched-type design with a 1:15 step-up transformer and a bouncer circuit to compensate the output phase droop within ±0.5%; it can drive a klystron up to 10 MW peak power, 1.5 ms rf pulse width, and 5 pps repetition rate. The main features of this modulator are four 50 kW switching power supplies in parallel to charge storage capacitors to 10 kV, self-healing-type storage capacitors to realize a compact capacitor bank, and a highly reliable IGBT switch which enables elimination of a crowbar circuit. Design considerations and its performance are presented. An IEGT (Injection Enhanced Gate Transistor) switch, composed of six series devices with a rating of 4.5 kV and 2100 A-DC, has been also developed and tested for R and D to realize a compact modulator. (author)

An improved fault-tolerant control scheme for PWM inverter-fed induction motor-based EVs.

Science.gov (United States)

Tabbache, Bekheïra; Benbouzid, Mohamed; Kheloui, Abdelaziz; Bourgeot, Jean-Matthieu; Mamoune, Abdeslam

2013-11-01

This paper proposes an improved fault-tolerant control scheme for PWM inverter-fed induction motor-based electric vehicles. The proposed strategy deals with power switch (IGBTs) failures mitigation within a reconfigurable induction motor control. To increase the vehicle powertrain reliability regarding IGBT open-circuit failures, 4-wire and 4-leg PWM inverter topologies are investigated and their performances discussed in a vehicle context. The proposed fault-tolerant topologies require only minimum hardware modifications to the conventional off-the-shelf six-switch three-phase drive, mitigating the IGBTs failures by specific inverter control. Indeed, the two topologies exploit the induction motor neutral accessibility for fault-tolerant purposes. The 4-wire topology uses then classical hysteresis controllers to account for the IGBT failures. The 4-leg topology, meanwhile, uses a specific 3D space vector PWM to handle vehicle requirements in terms of size (DC bus capacitors) and cost (IGBTs number). Experiments on an induction motor drive and simulations on an electric vehicle are carried-out using a European urban driving cycle to show that the proposed fault-tolerant control approach is effective and provides a simple configuration with high performance in terms of speed and torque responses. Copyright © 2013 ISA. Published by Elsevier Ltd. All rights reserved.

Induction accelerator test module for HIF

International Nuclear Information System (INIS)

Faltens, A.

1991-04-01

An induction linac test module suitable for investigating the drive requirements and the longitudinal coupling impedance of a high-power ion induction linac has been constructed by the Heavy Ion Fusion (HIF) group at LBL. The induction linac heavy ion driver for inertial confinement fusion (ICF) as presently envisioned uses multiple parallel beams which are transported in separate focusing channels but accelerated together in the induction modules. The resulting induction modules consequently have large beam apertures-1--2 meters in diameter- and correspondingly large outside diameters. The module geometry is related to a low-frequency ''gap capacity'' and high-frequency structural resonances, which are affected by the magnetic core loading and the module pulser impedance. A description of the test module and preliminary results are presented. 3 figs

4500 V SPT+ IGBT optimization on static and dynamic losses

International Nuclear Information System (INIS)

Dai Qingyun; Tian Xiaoli; Zhang Wenliang; Lu Shuojin; Zhu Yangjun

2015-01-01

This paper concerns the need for improving the static and dynamic performance of the high voltage insulated gate bipolar transistor (HV IGBTs). A novel structure with a carrier stored layer on the cathode side, known as an enhanced planar IGBT of the 4500 V voltage class is investigated. With the adoption of a soft punch through (SPT) concept as the vertical structure and an enhanced planar concept as the top structure, signed as SPT + IGBT, the simulation results indicate the turn-off switching waveform of the 4500 V SPT + IGBT is soft and also realizes an improved trade-off relationship between on-state voltage drop (V on ) and turn-off loss (E off ) in comparison with the SPT IGBT. Attention is also paid to the influences caused by different carrier stored layer doping dose on static and dynamic performances, to optimize on-state and switching losses of SPT + IGBT. (paper)

Scaling Rule for Very Shallow Trench IGBT toward CMOS Process Compatibility

OpenAIRE

Tanaka, Masahiro; Omura, Ichiro

2012-01-01

Deep trench gate is used for latest IGBT to improve device performance. By large difference from deep submicron CMOS structure, there is no process compatibility among CMOS device and trench gate IGBT. We propose IGBT scaling rule for shrinking IGBT cell structure both horizontally and vertically. The scaling rule is theoretically delivered by structure based equations. Device performance improvement was also predicted by TCAD simulations even with very shallow trench gate. The rule enables t...

TCAD analysis of short-circuit oscillations in IGBTs

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Iannuzzo, Francesco; Rahimo, Munaf

2017-01-01

Insulated-Gate Bipolar Transistors (IGBTs) exhibit a gate-voltage oscillation phenomenon during short-circuit, which can result in a gate-oxide breakdown. The oscillations have been investigated through device simulations and experimental investigations of a 3.3-kV IGBT. It has been found...... during short circuit....

Model of Transient Process Where Three-Phase Transducer Feeds Induction Motor Equivalent as a Variable Active-Inductive Load

Directory of Open Access Journals (Sweden)

Nenad Marković

2016-01-01

Full Text Available The paper presents a new approach in the analysis of a transient state in a system where the feeding source is a transducer-IGBT inverter and load is introduced through the induction motor with its R-L parameters. Induction motors with different parameters of powers and power factors are tested. MATLAB simulation of the three-phase inverter that feeds the induction machine has replaced the missing lab equipment with which mathematical model of this system was verified. According to the selected parameters of the inverter and induction machine and through the simulation in the MATLAB program, the results are obtained in the form of diagrams that verify the model of a transient state of the induction machine operation when it operates as a motor which is presented as a variable R-L load. The transient process of the system three-phase bridge inverter whose active-inductive load is the induction machine in the conditions of the change of the load parameters is analyzed. The model of the transient process in the system formed by the inverter in PWM (Pulse Width Modulation converter and induction machine is developed in the time domain and phase coordinates.

Effects of uneven temperature of IGBT and diode on switching characteristics of bridge legs in MW-level power converters

DEFF Research Database (Denmark)

Luo, Haoze; Iannuzzo, Francesco; Blaabjerg, Frede

2016-01-01

profile, the junction temperatures of inspected IGBT and related commutation diode are controlled independently using off-line test platform. In consideration of the structural layout, parasitic parameter effects and independent junction temperature control, a high-power switching characteristics platform...... was built. High power compact IGBT modules with 1.7kV rating and 3.6kA current rating are used for the experimental evaluation and platform feasibility. The quantitative analyses of uneven temperature effects on the switching characteristics are investigated and experimentally validated....

Full Digital Short Circuit Protection for Advanced IGBTs

OpenAIRE

谷村, 拓哉; 湯浅, 一史; 大村, 一郎

2011-01-01

A full digital short circuit protection method for advanced IGBTs has been proposed and experimentally demonstrated for the first time. The method employs combination of digital circuit, the gate charge sense instead of the conventional sense IGBT and analog circuit configuration. Digital protection scheme has significant advantages in thevprotection speed and flexibility.

A 1 MEGAWATT POLYPHASE BOOST CONVERTER-MODULATOR FOR KLYSTRON PULSE APPLICATION

International Nuclear Information System (INIS)

Reass, W.A.; Doss, J.D.; Gribble, R.F.

2001-01-01

This paper describes electrical design criteria and first operational results a 140 kV, 1 MW average, 11 MW peak, zero-voltage-switching 20 kHz polyphase bridge, boost converter/modulator for klystron pulse application. The DC-DC converter derives the buss voltages from a standard 13.8 kV to 2300 Y substation cast-core transformer. Energy storage and filtering is provided by self-clearing metallized hazy polypropylene traction capacitors. Three ''H-Bridge'' Insulated Gate Bipolar Transistor (IGBT) switching networks are used to generate the polyphase 20 kHz transformer primary drive waveforms. The 20 kHz drive waveforms are chirped the appropriate duration to generate the desired klystron pulse width. PWM (pulse width modulation) of the individual 20 kHz pulses is utilized to provide regulated output waveforms with adaptive feedforward and feedback techniques. The boost transformer design utilizes amorphous nanocrystalline material that provides the required low core loss at design flux levels and switching frequencies. Resonant shunt-peaking is used on the transformer secondary to boost output voltage and resonate transformer leakage inductance. With the appropriate transformer leakage inductance and peaking capacitance, zero-voltage-switching of the IGBT's is attained, minimizing switching losses. A review of these design parameters and the first results of the performance characteristics will be presented

NLC Hybrid Solid State Induction Modulator

CERN Document Server

Cassel, R L; Pappas, G C; Delamare, J E

2004-01-01

The Next Linear Collider accelerator proposal at SLAC requires a high efficiency, highly reliable, and low cost pulsed power modulator to drive the X-band klystrons. The original NLC envisions a solid state induction modulator design to drive up to 8 klystrons to 500 kV for 3 μs at 120 PPS with one modulator delivering greater than 1,000 MW pulse, at 500 kW average. A change in RF compression techniques resulted in only two klystrons needed pulsing per modulator at a reduced pulse width of 1.6 μsec or approximately 250 MW of the pulsed power and 80 kW of average powers. A prototype Design for Manufacturability (DFM) 8-pack modulator was under construction at the time of the change, so a redirection of modulator design was in order. To utilities the equipment which had already be fabricated, a hybrid modulator was designed and constructed using the DFM induction modulator parts and a conventional pulse transformer. The construction and performance of this hybrid two klystron Induction modul...

A novel TFS-IGBT with a super junction floating layer

International Nuclear Information System (INIS)

Ye Jun; Fu Daping; Luo Bo; Zhao Yuanyuan; Qiao Ming; Zhang Bo

2010-01-01

A novel trench field stop (TFS) IGBT with a super junction (SJ) floating layer (SJ TFS-IGBT) is proposed. This IGBT presents a high blocking voltage (> 1200 V), low on-state voltage drop and fast turn-off capability. A SJ floating layer with a high doping concentration introduces a new electric field peak at the anode side and optimizes carrier distribution, which will improve the breakdown voltage in the off-state and decrease the energy loss in the on-state/switching state for the SJ TFS-IGBT. A low on-state voltage (V F ) and a high breakdown voltage (BV) can be achieved by increasing the thickness of the SJ floating layer under the condition of exact charge balance. A low turn-off loss can be achieved by decreasing the concentration of the P-anode. Simulation results show that the BV is enhanced by 100 V, V F is decreased by 0.33 V(at 100 A/cm 2 ) and the turn-off time is shortened by 60%, compared with conventional TFS-IGBTs.

Experimental evaluation of IGBT junction temperature measurement via peak gate current

DEFF Research Database (Denmark)

Baker, Nick; Munk-Nielsen, Stig; Iannuzzo, Francesco

2015-01-01

Temperature sensitive electrical parameters allow junction temperature measurements on power semiconductors without modification to module packaging. The peak gate current has recently been proposed for IGBT junction temperature measurement and relies on the temperature dependent resistance...... of the gate pad. Consequently, a consideration of chip geometry and location of the gate pad is required before interpreting temperature data from this method. Results are also compared with a traditional electrical temperature measurement method: the voltage drop under low current....

Capacitive effects in IGBTs limiting their reliability under short circuit

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Iannuzzo, Francesco; Rahimo, Munaf

2017-01-01

The short-circuit oscillation mechanism in IGBTs is investigated in this paper by the aid of semiconductor device simulation tools. A 3.3-kV IGBT cell has been used for the simulations demonstrating that a single IGBT cell is able to oscillate together with the external circuit parasitic elements....... The work presented here through both circuit and device analysis, confirms that the oscillations can be understood with focus on the device capacitive effects coming from the interaction between carrier concentration and the electric field. The paper also shows the 2-D effects during one oscillation cycle...

Catastrophic Failure and Fault-Tolerant Design of IGBT Power Electronic Converters - An Overview

DEFF Research Database (Denmark)

Wu, Rui; Blaabjerg, Frede; Wang, Huai

2013-01-01

Reliability is one of the key issues for the application of Insulated Gate Bipolar Transistors (IGBTs) in power electronic converters. Many efforts have been devoted to the reduction of IGBT wear out failure induced by accumulated degradation and catastrophic failure triggered by single-event ove......Reliability is one of the key issues for the application of Insulated Gate Bipolar Transistors (IGBTs) in power electronic converters. Many efforts have been devoted to the reduction of IGBT wear out failure induced by accumulated degradation and catastrophic failure triggered by single...

Comparative Study of Fault Diagnostic Methods in Voltage Source Inverter Fed Three Phase Induction Motor Drive

Science.gov (United States)

Dhumale, R. B.; Lokhande, S. D.

2017-05-01

Three phase Pulse Width Modulation inverter plays vital role in industrial applications. The performance of inverter demeans as several types of faults take place in it. The widely used switching devices in power electronics are Insulated Gate Bipolar Transistors (IGBTs) and Metal Oxide Field Effect Transistors (MOSFET). The IGBTs faults are broadly classified as base or collector open circuit fault, misfiring fault and short circuit fault. To develop consistency and performance of inverter, knowledge of fault mode is extremely important. This paper presents the comparative study of IGBTs fault diagnosis. Experimental set up is implemented for data acquisition under various faulty and healthy conditions. Recent methods are executed using MATLAB-Simulink and compared using key parameters like average accuracy, fault detection time, implementation efforts, threshold dependency, and detection parameter, resistivity against noise and load dependency.

Multilevel DC Link Inverter for Brushless Permanent Magnet Motors with Very Low Inductance

International Nuclear Information System (INIS)

Su, G.J.

2001-01-01

Due to their long effective air gaps, permanent magnet motors tend to have low inductance. The use of ironless stator structure in present high power PM motors (several tens of kWs) reduces the inductance even further ( and lt; 100(micro)H). This low inductance imposes stringent current regulation demands for the inverter to obtain acceptable current ripple. An analysis of the current ripple for these low inductance brushless PM motors shows that a standard inverter with the most commonly used IGBT switching devices cannot meet the current regulation demands and will produce unacceptable current ripples due to the IGBT's limited switching frequency. This paper introduces a new multilevel dc link inverter, which can dramatically reduce the current ripple for brushless PM motor drives. The operating principle and design guidelines are included

Experimental Evaluation of IGBT Junction Temperature Measurement via a Modified-VCE (ΔVCE_ΔVGE) Method with Series Resistance Removal

DEFF Research Database (Denmark)

Baker, Nick; Iannuzzo, Francesco; Munk-Nielsen, Stig

2016-01-01

Temperature sensitive electrical parameters (TSEPs) allow junction temperature measurements on power semiconductors without modification to module packaging. The on-state collector-emitter voltage (VCE) in IGBTs is an attractive option for junction temperature measurement since it is relatively e...

Solid-state high voltage modulator and its application to rf source high voltage power supplies

International Nuclear Information System (INIS)

Tooker, J.F.; Huynh, P.; Street, R.W.

2009-01-01

A solid-state high voltage modulator is described in which series-connected insulated-gate bipolar transistors (IGBTs) are switched at a fixed frequency by a pulse width modulation (PWM) regulator, that adjusts the pulse width to control the voltage out of an inductor-capacitor filter network. General Atomics proposed the HV power supply (HVPS) topology of multiple IGBT modulators connected to a common HVdc source for the large number of 1 MW klystrons in the linear accelerator of the Accelerator Production of Tritium project. The switching of 24 IGBTs to obtain 20 kVdc at 20 A for short pulses was successfully demonstrated. This effort was incorporated into the design of a -70 kV, 80 A, IGBT modulator, and in a short-pulse test 12 IGBTs regulated -5 kV at 50 A under PWM control. These two tests confirm the practicality of solid-state IGBT modulators to regulate high voltage at reasonable currents. Tokamaks such as ITER require large rf heating and current drive systems with multiple rf sources. A HVPS topology is presented that readily adapts to the three rf heating systems on ITER. To take advantage of the known economy of scale for power conversion equipment, a single HVdc source feeds multiple rf sources. The large power conversion equipment, which is located outside, converts the incoming utility line voltage directly to the HVdc needed for the class of rf sources connected to it, to further reduce cost. The HVdc feeds a set of IGBT modulators, one for each rf source, to independently control the voltage applied to each source, maximizing operational flexibility. Only the modulators are indoors, close to the rf sources, minimizing the use of costly near-tokamak floor space.

Active gate driver for dv/dt control and active voltage clamping in an IGBT stack

DEFF Research Database (Denmark)

Rasmussen, Tonny Wederberg

2005-01-01

For high voltages converters stacks of IGBTs can be used if the static and dynamic voltage sharing among the IGBTs can be applied. dVCE/dt should also be controlled in order not to damage insulation material. This paper describes theory and measurements of an active gate driver for stacking IGBTs....... For the measurements two series connected standard IGBTs made for hard switching applications are used. Problems are shown and proposals for improvements are given....

Determination of modeling parameters for power IGBTs under pulsed power conditions

Energy Technology Data Exchange (ETDEWEB)

Dale, Gregory E [Los Alamos National Laboratory; Van Gordon, Jim A [U. OF MISSOURI; Kovaleski, Scott D [U. OF MISSOURI

2010-01-01

While the power insulated gate bipolar transistor (IGRT) is used in many applications, it is not well characterized under pulsed power conditions. This makes the IGBT difficult to model for solid state pulsed power applications. The Oziemkiewicz implementation of the Hefner model is utilized to simulate IGBTs in some circuit simulation software packages. However, the seventeen parameters necessary for the Oziemkiewicz implementation must be known for the conditions under which the device will be operating. Using both experimental and simulated data with a least squares curve fitting technique, the parameters necessary to model a given IGBT can be determined. This paper presents two sets of these seventeen parameters that correspond to two different models of power IGBTs. Specifically, these parameters correspond to voltages up to 3.5 kV, currents up to 750 A, and pulse widths up to 10 {micro}s. Additionally, comparisons of the experimental and simulated data will be presented.

Effects of Auxiliary-Source Connection in Multichip Power Module

DEFF Research Database (Denmark)

Li, Helong; Munk-Nielsen, Stig; Wang, Xiongfei

2017-01-01

the power loop and the gate loop like how the Kelvin-source connection does, owing to their involvement in the loop of the power source current. Three effects of the auxiliary-source connections are then analyzed, which are 1) the common source stray inductance reduction, 2) the transient drain......Auxiliary-source bond wires and connections are widely used in power modules with paralleled MOSFETs or IGBTs. This paper investigates the operation mechanism of the auxiliary-source connections in multichip power modules. It reveals that the auxiliary-source connections cannot fully decouple......-source current imbalance mitigation, and 3) the influence on the steady-state current distribution. Lastly, simulations and experimental results validate the theoretical analysis....

Optimalization of IGBT Communication

Directory of Open Access Journals (Sweden)

Pavol Spanik

2002-01-01

Full Text Available The paper presents IGBT switch off process in order to reduce power loss in the structure. The soft switching method using switch-off after current reduction is used. Process mentioned above is optimized to minimize the power loss that is determined by experiment. Results obtained in the experiment can be helpful in a converter and controller design process.

A study of s new power semiconductor insulated gate bipolar transistor (IGBT) characteristics and its application to automotive ignition

International Nuclear Information System (INIS)

Rabah, K.V.O.

1995-05-01

Assessment has been made of the problem of the on-resistance and temperature effects in the three power transistor combinations, such as Darlington-types or IGBT. The IGBT is a device in which the drain of the MOSFET feeds the bipolar base in monolithic (IC and Power on the same chip) to give it both the MOS and bipolar advantages. The high temperature operating characteristics of the device are discussed and compared to that of power bipolar transistor. Unlike the power bipolar transistor whose operating current density shows current crowding at above forward collector current of 4Amps and forward voltage drop above 0.4V, the IGBT is found to maintain its high current density above forward collector of current 1Amp (or a forward voltage drop above 1.2V). The results also indicate that these devices (IGBTs) can be interdigited (paralleled) without current hogging problems if the forward conduction occurs at forward voltage drops in excess of 1.2V, and this makes it the best candidate for automotive ignition power switches. (author). 20 refs, 10 figs, 1 tab

Fabrication and electrical characterization of ultra-thin substrate IGBT

OpenAIRE

Guhathakurta, Jajnabalkya

2013-01-01

Current topics such as electro-mobility and renewable energy demand the development of power devices with high voltage and current ratings along with minimum switching losses. Amongst the power devices in today’s market, IGBTs have gained a lot of significance in this field over its competitors like Power MOSFETS and Thyristors. Today’s industry has recently taken a huge step in this direction to implement the use of thin-wafer technology for fabrication of IGBTs to reduce the on-resistance. ...

Increasing emitter efficiency in 3.3-kV enhanced trench IGBTs for higher short-circuit capability

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Iannuzzo, Francesco; Rahimo, Munaf

2018-01-01

In this paper, a 3.3-kV Enhanced Trench IGBT has been designed with a high emitter efficiency, for improving its short-circuit robustness. The carrier distribution profile has been shaped in a way that it is possible to increase the electric field at the surface of the IGBT, and thereby, counteract...... the Kirk Effect onset. This design approach is beneficial for mitigating high-frequency oscillations, typically observed in IGBTs under short-circuit conditions. The effectiveness of the proposed design rule is validated by means of mixed-mode device simulations. Then, two IGBTs have been fabricated...... with different emitter efficiencies and tested under short circuit, validating that the high-frequency oscillations can be mitigated, with higher emitter efficiency IGBT designs....

Study of an Insulated Gate Bipolar Transistor (IGBT) and its connection in series. Application at a chopper 1500V-5A-10kHz

International Nuclear Information System (INIS)

Gros, P.

1993-01-01

In the frame of the tokamak ITER (International Thermonuclear Experimental Reactor) we have studied, for neutral particle injection, a converter with at least two static interrupters by Mosfet transistor, bipolar transistor or Insulated Gate Bipolar Transistor (IGBT). After a comparison between these three types of transistors, by the simulating software MICROCAP, a serial of tests has shown the advantages of the IGBT. A command, associated with two IGBT of equivalent characteristics, has given a simple and efficacious solution. The performances are: (1) between two blockages: 50 ns without overvoltage, (2) between two cut-off: 60 ns. 40 figs; 30 refs; 10 annexes

Feasibility of applying home-made amorphous core to induction module

International Nuclear Information System (INIS)

Chen Sifu; Li Xin; Huang Ziping

2008-01-01

The application of the homemade 1K101 amorphous core in induction module is reported in this paper. The properties of magnetic, insulation and stability are studied with the cores. A pulse with pulse width of 120 ns (FWFM), flattop of 72 ns (±1%) and rise time of 17 ns can be obtained with single-pulse induction module. Triple-pulse with the rise time of 35 ns, flat-top of 60 ns (±1%) and pulse width of 120 ns (FWFM) was obtained when tested with a formal linear induction module at MHz repetition burst mode. The effective average flux swing of the amorphous core is about 1.41 T. The cores work well with triple-pulse of 282 kV. The properties of the cores are stable and suitable for induction module. (authors)

The Fault Detection, Localization, and Tolerant Operation of Modular Multilevel Converters with an Insulated Gate Bipolar Transistor (IGBT Open Circuit Fault

Directory of Open Access Journals (Sweden)

Wei Li

2018-04-01

Full Text Available Reliability is one of the critical issues for a modular multilevel converter (MMC since it consists of a large number of series-connected power electronics submodules (SMs. In this paper, a complete control strategy including fault detection, localization, and tolerant operation is proposed for the MMC under an insulated gate bipolar transistor (IGBT open circuit fault. According to the output characteristics of the SM with the open-circuit fault of IGBT, a fault detection method based on the circulating current and output current observation is used. In order to further precisely locate the position of the faulty SM, a fault localization method based on the SM capacitor voltage observation is developed. After the faulty SM is isolated, the continuous operation of the converter is ensured by adopting the fault-tolerant strategy based on the use of redundant modules. To verify the proposed fault detection, fault localization, and fault-tolerant operation strategies, a 900 kVA MMC system under the conditions of an IGBT open circuit is developed in the Matlab/Simulink platform. The capabilities of rapid detection, precise positioning, and fault-tolerant operation of the investigated detection and control algorithms are also demonstrated.

A Study on the Improvement of Switching Speed of NPT-IGBT by Fast Neutron Irradiation

Energy Technology Data Exchange (ETDEWEB)

Baek, H. N.; Sun, G. M.; Kim, J. S.; Hoang, S. M. T.; Jin, M. E.; Jin, S. B.; Ahn, S. H. [KAERI, Daejeon (Korea, Republic of)

2016-05-15

The insulated gate bipolar transistor (IGBT) has been widely used for high power switching devices due to low on-state forward voltage drop and fast switching speed. But, turn-off delay time occurs due to the tail current generated by the minority carrier existing in the n-drift region during turn-off, which reduces the switching speed. Recently, to mitigate this problem, studies on the control of the MCLT to improve the switching speed of IGBTs are carried out. A crystal defect is formed in the n-drift region of an IGBT to realize a deep energy level within the energy band. The deep level act as the recombination center of the minority carrier to reduce the turn-off delay time and control the lifetime by reducing the lifetime of the minority carrier injected during the device operation. The particle-beam irradiation method, such as electron, proton, fast neutron and others, has been used to control the lifetime of the minority carrier of a silicon power semiconductor device. To improve the switching speed of a IGBT, devices were produced by irradiating various doses of fast neutron, and electrical properties were comparatively analyzed with the IGBT device where before irradiated. The reduced in the lifetime of the minority carrier flowing into the n-drift region due to the crystal defect helps improve the switching speed of the IGBT. But, the resistance component increased due to the crystal defect generated by the fast neutron irradiation in the on-state, increasing of the forward voltage drop. So, to improve and optimize the IGBT performance, appropriate condition should be determined by trading off each electrical properties.

A Study on the Improvement of Switching Speed of NPT-IGBT by Fast Neutron Irradiation

International Nuclear Information System (INIS)

Baek, H. N.; Sun, G. M.; Kim, J. S.; Hoang, S. M. T.; Jin, M. E.; Jin, S. B.; Ahn, S. H.

2016-01-01

The insulated gate bipolar transistor (IGBT) has been widely used for high power switching devices due to low on-state forward voltage drop and fast switching speed. But, turn-off delay time occurs due to the tail current generated by the minority carrier existing in the n-drift region during turn-off, which reduces the switching speed. Recently, to mitigate this problem, studies on the control of the MCLT to improve the switching speed of IGBTs are carried out. A crystal defect is formed in the n-drift region of an IGBT to realize a deep energy level within the energy band. The deep level act as the recombination center of the minority carrier to reduce the turn-off delay time and control the lifetime by reducing the lifetime of the minority carrier injected during the device operation. The particle-beam irradiation method, such as electron, proton, fast neutron and others, has been used to control the lifetime of the minority carrier of a silicon power semiconductor device. To improve the switching speed of a IGBT, devices were produced by irradiating various doses of fast neutron, and electrical properties were comparatively analyzed with the IGBT device where before irradiated. The reduced in the lifetime of the minority carrier flowing into the n-drift region due to the crystal defect helps improve the switching speed of the IGBT. But, the resistance component increased due to the crystal defect generated by the fast neutron irradiation in the on-state, increasing of the forward voltage drop. So, to improve and optimize the IGBT performance, appropriate condition should be determined by trading off each electrical properties

Investigation and Classification of Short-Circuit Failure Modes Based on Three-Dimensional Safe Operating Area for High-Power IGBT Modules

DEFF Research Database (Denmark)

Chen, Yuxiang; Li, Wuhua; Iannuzzo, Francesco

2018-01-01

is implemented to motivate advanced contributions in future dependence research of device short-circuit failure modes on temperature. Consequently, a comprehensive and thoughtful review of where the development of short-circuit failure mode research works of IGBT stands and is heading is provided....

Testing and verification of a novel single-channel IGBT driver circuit

OpenAIRE

Lukić, Milan; Ninković, Predrag

2016-01-01

This paper presents a novel single-channel IGBT driver circuit together with a procedure for testing and verification. It is based on a specialized integrated circuit with complete range of protective functions. Experiments are performed to test and verify its behaviour. Experimental results are presented in the form of oscilloscope recordings. It is concluded that the new driver circuit is compatible with modern IGBT transistors and power converter demands and that it can be applied in new d...

Design and Construction of Power System for Induction Heating (IH) Cooker Using Resonant Converter

International Nuclear Information System (INIS)

Soe Thiri Thandar; Clement Saldanah; Win Khaing Moe

2008-06-01

Induction Heating (IH) systems using electromagnetic induction are developed in many industrial applications in Myanmar. Many industries have benefited from this new breakthrough by implementing induction heating for melting, hardening, and heating. Induction heating cooker is based on high frequency induction heating,electrical and electronic technologies. From the electronic point of view, induction heating cooker is composed of four parts.They are rectifier, filter, high frequency inverter, and resonant load. The purpose of this research is mainly objected to developed an induction heating cooker. The rectifier module is considered as full-bridge rectifier. The second protion of the system is a capacitive filter. The ripple components are minimized by this filter. The third is a high frequency converter to convert the constant DC to high frequency AC by switching the devices alternately. In this research, the Insulated Gate Bipolar Transistor (IGBT) will be used as a power source, and can be driven by the pulse signals from the pulse transformer circuit. In the resonant load, the power consumption is about 500W. Construction and testing has been carried out. The merits of this research work is that IH cooker can be developed because of having less energy consumption, safe, efficient, quick heating, and having efficiency of 90% or more

Remaining Useful Life Estimation of Insulated Gate Biploar Transistors (IGBTs Based on a Novel Volterra k-Nearest Neighbor Optimally Pruned Extreme Learning Machine (VKOPP Model Using Degradation Data

Directory of Open Access Journals (Sweden)

Zhen Liu

2017-11-01

Full Text Available The insulated gate bipolar transistor (IGBT is a kind of excellent performance switching device used widely in power electronic systems. How to estimate the remaining useful life (RUL of an IGBT to ensure the safety and reliability of the power electronics system is currently a challenging issue in the field of IGBT reliability. The aim of this paper is to develop a prognostic technique for estimating IGBTs’ RUL. There is a need for an efficient prognostic algorithm that is able to support in-situ decision-making. In this paper, a novel prediction model with a complete structure based on optimally pruned extreme learning machine (OPELM and Volterra series is proposed to track the IGBT’s degradation trace and estimate its RUL; we refer to this model as Volterra k-nearest neighbor OPELM prediction (VKOPP model. This model uses the minimum entropy rate method and Volterra series to reconstruct phase space for IGBTs’ ageing samples, and a new weight update algorithm, which can effectively reduce the influence of the outliers and noises, is utilized to establish the VKOPP network; then a combination of the k-nearest neighbor method (KNN and least squares estimation (LSE method is used to calculate the output weights of OPELM and predict the RUL of the IGBT. The prognostic results show that the proposed approach can predict the RUL of IGBT modules with small error and achieve higher prediction precision and lower time cost than some classic prediction approaches.

Updating the induction module from single-pulse to double-pulses

International Nuclear Information System (INIS)

Huang Ziping; Wang Huacen; Deng Jianjun

2002-01-01

A double-pulse Linear Induced Accelerator (LIA) module is reconstructed based on a usual simple-pulse LIA module. By changing the length of one of the cables between the inductive cell and the Blumlein pulse forming line, two induction pulses with 90 ns FWHM and 150 kV pulse voltage are generated by the ferrite cores inductive cell. The interval time of the pulses is adjustable by changing the lengths of the cable

Modeling of a Stacked Power Module for Parasitic Inductance Extraction

Science.gov (United States)

2017-09-15

ARL-TR-8138 ● SEP 2017 US Army Research Laboratory Modeling of a Stacked Power Module for Parasitic Inductance Extraction by...not return it to the originator. ARL-TR-8138 ● SEP 2017 US Army Research Laboratory Modeling of a Stacked Power Module for... Power Module for Parasitic Inductance Extraction 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6. AUTHOR(S) Steven Kaplan

Testing and verification of a novel single-channel IGBT driver circuit

Directory of Open Access Journals (Sweden)

Lukić Milan

2016-01-01

Full Text Available This paper presents a novel single-channel IGBT driver circuit together with a procedure for testing and verification. It is based on a specialized integrated circuit with complete range of protective functions. Experiments are performed to test and verify its behaviour. Experimental results are presented in the form of oscilloscope recordings. It is concluded that the new driver circuit is compatible with modern IGBT transistors and power converter demands and that it can be applied in new designs. It is a part of new 20kW industrial-grade boost converter.

Modelling the clamping force distribution among chips in press-pack IGBTs using the finite element method

DEFF Research Database (Denmark)

Hasmasan, Adrian Augustin; Busca, Christian; Teodorescu, Remus

2012-01-01

In this paper, a FEM (finite element method) based mechanical model for PP (press-pack) IGBTs (insulated gate bipolar transistors) is presented, which can be used to calculate the clamping force distribution among chips under various clamping conditions. The clamping force is an important parameter...... for the chip, because it influences contact electrical resistance, contact thermal resistance and power cycling capability. Ideally, the clamping force should be equally distributed among chips, in order to maximize the reliability of the PP IGBT. The model is built around a hypothetical PP IGBT with 9 chips......, and it has numerous simplifications in order to reduce the simulation time as much as possible. The developed model is used to analyze the clamping force distribution among chips, in various study cases, where uniform and non-uniform clamping pressures are applied on the studied PP IGBT....

Reliability-Driven Assessment of GaN HEMTs and Si IGBTs in 3L-ANPC PV Inverters

DEFF Research Database (Denmark)

Gurpinar, Emre; Yang, Yongheng; Iannuzzo, Francesco

2016-01-01

In this paper, thermal loading of the state-of-the-art GaN HEMTs and traditional Si IGBTs in 3L-ANPC PV inverters is presented considering real-field long-term mission profiles (i.e., ambient temperature and solar irradiance). A comparison of Si IGBT against GaN HEMT with three different possibil......In this paper, thermal loading of the state-of-the-art GaN HEMTs and traditional Si IGBTs in 3L-ANPC PV inverters is presented considering real-field long-term mission profiles (i.e., ambient temperature and solar irradiance). A comparison of Si IGBT against GaN HEMT with three different...... be achieved without compromise of operating efficiency with GaN HEMTs. Both simulations and experimental tests are provided to demonstrate the thermal loading analysis approach. More important, the proposed analysis and comparison approach can be used for lifetime and reliability analysis of wide...

The snap-back effect of an RC-IGBT and its simulations

International Nuclear Information System (INIS)

Zhang Wenliang; Tian Xiaoli; Zhu Yangjun; Tan Jingfei

2013-01-01

The RC-IGBT (reverse conducting insulated gate bipolar transistor) is a new kind of power semiconductor device which has many advantages such as smaller chip size, higher power density, lower manufacturing cost, softer turn off behavior, and better reliability. However, its performance has a number of drawbacks, such as the snap-back effect. In this paper, an introduction about the snap-back effect of the RC-IGBT is given firstly. Then the physical explanations are presented with two simplified models. After that, some numerical simulations are carried out to verify the correctness of the models. (semiconductor devices)

100 kV, 80 kJ low-induction capacitor module

International Nuclear Information System (INIS)

Andrezen, A.B.; Burtsev, V.A.; Vodovozov, V.M.; Drozdov, A.A.; Makeev, G.M.

1980-01-01

A low induction capacitor module has been developed to investigate THETA- and Z-pinch plasma. Energy output time of the module lays in the microsecond range. The 100 kV, 80 kJ module is based on low-induction castor capasitors. The module is equipped with two solid dielectric dischargers, the system of discharger ignition protection system and automatic system for charging of capacitors. The module discharge period T 0 =5.6 μs. The capacitor module has been used in investigations of electric explosions of Al plane foils in the pulverized quartz. The overvoltage Usub(max)/Usub(o) approximately equal to 10 has been received at the maximum intensity of the electric field Esub(max) approximately equal to 12 kV/sm [ru

New layout concepts in MW-scale IGBT modules for higher robustness during normal and abnormal operations

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Iannuzzo, Francesco; Munk-Nielsen, Stig

2016-01-01

the Finite-Element-Method AnSYS Q3D Extractor, electromagnetic simulations are conducted to extract the self and mutual inductance from the six different layouts. PSpice simulations are used to reveal that the stray parameters inside the module play an important role under normal and abnormal operations...

Mission Profile Based Sizing of IGBT Chip Area for PV Inverter Applications

DEFF Research Database (Denmark)

Shen, Yanfeng; Wang, Huai; Yang, Yongheng

2016-01-01

Maximizing the total energy generation is of importance for Photovoltaic (PV) plants. This paper proposes a method to optimize the IGBT chip area for PV inverters to minimize the annual energy loss of the active switches based on long-term operation conditions (i.e., mission profile). The design...... yearly mission profile. Simulation results are given to verify the thermal characteristics. Furthermore, a Monte Carlo based lifetime evaluation is presented to check the IGBT reliability. The proposed design method enables a reliability-oriented energy optimized sizing of active switches for PV inverter...

Introduction to the reliability study of IGBT switching cells under strong constraints; Introduction a l'etude de la fiabilite des cellules de commutation a IGBT sous fortes contraintes

Energy Technology Data Exchange (ETDEWEB)

Vallon, J.

2003-12-15

The reliability approach in power electronics is a complex problem including the coupling of current / voltage surges, physical and technological imperfections, from the die to the power circuit. First of all, we define a methodology based on the monitoring of a great number of components, during a long time campaign. Components are 600 V-50 A-20 kHz IGBT-diodes modules working in PWM inverter cells owing to an original opposition method. An exhaustive study of cell-switching failure modes allowed us to design a suitable and efficient protection. Afterwards, a complete reliability test bench was carried out with electrical and thermal monitoring. A preliminary screening protocol was also applied. The first results are presented in this thesis. (author)

Fast and Accurate Icepak-PSpice Co-Simulation of IGBTs under Short-Circuit with an Advanced PSpice Model

DEFF Research Database (Denmark)

Wu, Rui; Iannuzzo, Francesco; Wang, Huai

2014-01-01

A basic problem in the IGBT short-circuit failure mechanism study is to obtain realistic temperature distribution inside the chip, which demands accurate electrical simulation to obtain power loss distribution as well as detailed IGBT geometry and material information. This paper describes an unp...

Reliability Estimation with Uncertainties Consideration for High Power IGBTs in 2.3 MW Wind Turbine Converter System

DEFF Research Database (Denmark)

Kostandyan, Erik; Ma, Ke

2012-01-01

This paper investigates the lifetime of high power IGBTs (insulated gate bipolar transistors) used in large wind turbine applications. Since the IGBTs are critical components in a wind turbine power converter, it is of great importance to assess their reliability in the design phase of the turbine....... Minimum, maximum and average junction temperatures profiles for the grid side IGBTs are estimated at each wind speed input values. The selected failure mechanism is the crack propagation in solder joint under the silicon die. Based on junction temperature profiles and physics of failure model......, the probabilistic and determinist damage models are presented with estimated fatigue lives. Reliably levels were assessed by means of First Order Reliability Method taking into account uncertainties....

Dynamic thermal modelling and analysis of press-pack IGBTs both at component-level and chip-level

DEFF Research Database (Denmark)

Busca, Cristian; Teodorescu, Remus; Blaabjerg, Frede

2013-01-01

curves under various mechanical clamping conditions are derived. Moreover, the deformation of the internal components of the PP IGBT under operating-like conditions is investigated with the help of the thermal models and the coefficient of thermal expansion (CTE) information.......Thermal models are needed when designing power converters for Wind Turbines (WTs) in order to carry out thermal and reliability assessment of certain designs. Usually the thermal models of Insulated Gate Bipolar Transistors (IGBTs) are given in the datasheet in various forms at component......-level, not taking into account the thermal distribution among the chips. This is especially relevant in the case of Press-Pack (PP) IGBTs because any non-uniformity of the clamping pressure can affect the chip-level thermal impedances. This happens because the contact thermal resistances in the thermal impedance...

Investigation of induction cells and modulator design for heavy ion accelerators

International Nuclear Information System (INIS)

Fong, C.G.; Reginato, L.R.

1992-01-01

The induction linear accelerator has been a leading candidate in the U.S. for the acceleration of high current heavy ion beams to initiate inertial confinement fusion (ICF). This paper describes the rather unique parameters derived from the accelerator beam dynamics, and addresses the design and development of accelerator induction cells and their modulators to be used in a near-term driver scaling experiment named the Induction Linac Systems Experiments (ILSE) planned for construction starting in 1994. Work is underway to develop the cells and their pulse modulators. Tradeoffs between the amorphous core material, pulse length, rise and fall time are made against efficiency, costs and technical risks are discussed

Development of a Respiratory Inductive Plethysmography Module Supporting Multiple Sensors for Wearable Systems

Directory of Open Access Journals (Sweden)

Zhengbo Zhang

2012-09-01

Full Text Available In this paper, we present an RIP module with the features of supporting multiple inductive sensors, no variable frequency LC oscillator, low power consumption, and automatic gain adjustment for each channel. Based on the method of inductance measurement without using a variable frequency LC oscillator, we further integrate pulse amplitude modulation and time division multiplexing scheme into a module to support multiple RIP sensors. All inductive sensors are excited by a high-frequency electric current periodically and momentarily, and the inductance of each sensor is measured during the time when the electric current is fed to it. To improve the amplitude response of the RIP sensors, we optimize the sensing unit with a matching capacitor parallel with each RIP sensor forming a frequency selection filter. Performance tests on the linearity of the output with cross-sectional area and the accuracy of respiratory volume estimation demonstrate good linearity and accurate lung volume estimation. Power consumption of this new RIP module with two sensors is very low. The performance of respiration measurement during movement is also evaluated. This RIP module is especially desirable for wearable systems with multiple RIP sensors for long-term respiration monitoring.

On-state voltage drop based power limit detection of IGBT inverters

DEFF Research Database (Denmark)

Trintis, Ionut; Ghimire, Pramod; Munk-Nielsen, Stig

2015-01-01

Power density is a key performance factor in order to reduce the cost and size of a power converter. Because of the unknown junction temperature, today’s design margins are relatively high to ensure safe and a reliable operation. In this paper, the on-state voltage drop is measured online for all...... insulated gate bipolar transistors (IGBTs) in the inverter, using advanced gate driver. The die temperature is estimated and monitored on each device during power converter operation. Based on the monitored temperature in real time, the maximum power capability is detected. The output power is increased...... until a safe operating temperature of power modules. This enable a power density is increased by 11.16 kW/litre to 19.13 kW/litre in a low voltage power stack which is typically used in wind power converters. Experiment results are shown for safe operation of converter at around 1.2 MW, which is built...

2.3-MW Medium-Voltage, Three-Level Wind Energy Inverter Applying a Unique Bus Structure and 4.5-kV Si/SiC Hybrid Isolated Power Modules: Preprint

Energy Technology Data Exchange (ETDEWEB)

Erdman, W.; Keller, J.; Grider, D.; VanBrunt, E.

2014-11-01

A high-efficiency, 2.3-MW, medium-voltage, three-level inverter utilizing 4.5-kV Si/SiC (silicon carbide) hybrid modules for wind energy applications is discussed. The inverter addresses recent trends in siting the inverter within the base of multimegawatt turbine towers. A simplified split, three-layer laminated bus structure that maintains low parasitic inductances is introduced along with a low-voltage, high-current test method for determining these inductances. Feed-thru bushings, edge fill methods, and other design features of the laminated bus structure provide voltage isolation that is consistent with the 10.4-kV module isolation levels. Inverter efficiency improvement is a result of the (essential) elimination of the reverse recovery charge present in 4.5-kV Si PIN diodes, which can produce a significant reduction in diode turn-off losses as well as insulated-gate bipolar transistor (IGBT) turn-on losses. The hybrid modules are supplied in industry-standard 140 mm x 130 mm and 190 mm x 130 mm packages to demonstrate direct module substitution into existing inverter designs. A focus on laminated bus/capacitor-bank/module subassembly level switching performance is presented.

A commutation strategy for IGBT-based CSI-fed parallel resonant

Indian Academy of Sciences (India)

The dynamic behaviour of the switches decides the upper frequency limit for the application. IGBTs with the series diodes behave as uni-directional current switches with bi-directional voltage blocking capability. This feature should be taken into account to decide on an appropriate switching strategy for this converter ...

Design of a low parasitic inductance SiC power module with double-sided cooling

Energy Technology Data Exchange (ETDEWEB)

Yang, Fei [The University of Tennessee, Knoxville; Liang, Zhenxian [Cree Inc.; Wang, Fei [ORNL; Wang, Zhiqiang [ORNL

2017-03-01

In this paper, a low-parasitic inductance SiC power module with double-sided cooling is designed and compared with a baseline double-sided cooled module. With the unique 3D layout utilizing vertical interconnection, the power loop inductance is effectively reduced without sacrificing the thermal performance. Both simulations and experiments are carried out to validate the design. Q3D simulation results show a power loop inductance of 1.63 nH, verified by the experiment, indicating more than 60% reduction of power loop inductance compared with the baseline module. With 0Ω external gate resistance turn-off at 600V, the voltage overshoot is less than 9% of the bus voltage at a load of 44.6A.

Study of Power Loss Reduction in SEPR Converters for Induction Heating through Implementation of SiC Based Semiconductor Switches

Directory of Open Access Journals (Sweden)

Angel Marinov

2014-08-01

Full Text Available This paper presents a power loss analysis for a Single Ended Parallel Resonance (SEPR Converter used for induction heating. The analysis includes a comparison of the losses in the electronic switch when the circuit is realized using a conventional Silicon (Si based IGBT or when using Silicon Carbide (SiC based MOSFET. The analysis includes modelling and simulation as well as experimental verification through power loss and heat dissipation measurement. The presented results can be used as a base of comparison between the switches and can be a starting point for efficiency based design of those types of converters.

Au–Sn bonding material for the assembly of power integrated circuit module

Energy Technology Data Exchange (ETDEWEB)

Zhu, Z.X.; Li, C.C. [Department of Materials Science & Engineering, National Taiwan University, Taipei, Taiwan (China); Liao, L.L.; Liu, C.K. [Electronic and Optoelectronics Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan (China); Kao, C.R., E-mail: crkao@ntu.edu.tw [Department of Materials Science & Engineering, National Taiwan University, Taipei, Taiwan (China)

2016-06-25

Insulated gate bipolar transistor (IGBT) chips are the key components in high-temperature power electronic modules, which have to efficiently convert electricity between direct and alternating current. In this study, the eutectic Au–Sn (20 wt.% Sn) is successfully used to assemble IGBT chips and direct-bond-copper substrates by using solid liquid interdiffusion (SLID) bonding. During subsequent isothermal aging at 150, 200, and 240 °C, the microstructure evolution and growth kinetics of intermetallic compounds are investigated. Excellent thermal stability and mechanical strength are observed. It is concluded that the eutectic Au–Sn solder is ideal to assemble high-temperature IGBT by using the SLID process. - Highlights: • Au–20Sn serves as a promising bonding material for IGBT operating at T < 519 °C. • The Au–20Sn reacted with Ni to form (Ni,Au){sub 3}Sn{sub 2}/(Au{sub 5}Sn + AuSn)/(Ni,Au){sub 3}Sn{sub 2}. • Once the AuSn was nearly exhausted, the whole joint could withstand higher temperatures. • A cost-effective way for long-term operations at high temperature.

Measures for instantaneous voltage drop and UPS market (activities of individual companies). Technology development of large-capacity UPS system; Shunji den`atsu teika taisaku to UPS shijo. Daiyoryo UPS system no gijutsu kaihatsu

Energy Technology Data Exchange (ETDEWEB)

Motoki, Y. [Fuji Electric Co. Ltd., Tokyo (Japan)

1998-07-01

This paper describes development of large-capacity UPS (uninterruptive power source) for large-capacity computer systems by Fuji Electric. This UPS is composed of a rectifier, inverter, transformer, and ac filter. The rectifier and inverter are composed of the same IGBT power modules. The IGBT power module has an integrated structure consisting of IGBT, gate driving circuit, snubber circuit, electrolytic capacitor, cooling fin, and fuse. Downsizing of snubber circuit and improvement of mounting efficiency were realized by developing a large current substrate with small wiring inductance. Advanced input/output performance and control characteristics of USP were realized by the digital control using RISC and DSP of high-speed processor. For the inverter control algorithm, PWM pulse can be calculated using parameters derived from the state equation of the main circuit constants. The output voltage distortion factor less than 5% was realized at the nonlinear load of 100%. The UPS systems in the out-sourcing business and large-scale business center are illustrated as examples. 6 figs.

Redundancy Determination of HVDC MMC Modules

Directory of Open Access Journals (Sweden)

Chanki Kim

2015-08-01

Full Text Available An availability and a reliability prediction has been made for a high-voltage direct-current (HVDC module of VSC (Voltage Source Converter containing DC/DC converter, gate driver, capacitor and insulated gate bipolar transistors (IGBT. This prediction was made using published failure rates for the electronic equipment. The purpose of this prediction is to determinate the additional module redundancy of VSC and the used method is “binomial failure method”.

Power electronic modules design and manufacture

CERN Document Server

Sheng, William W

2004-01-01

IntroductionSelection ProcedureMaterialsInsulating Substrate and MetallizationBase PlateBonding MaterialPower Interconnection and TerminalEncapsulantPlastic Case and Cover Manufacturing of Power IGBT ModulesManufacturing Process Process Control/Long-Term ReliabilityManufacturing FacilitiesManufacturing Flow Charts DesignThermal ManagementCircuit PartitioningDesign Guidelines and ConsiderationsThermal Results of Different Samples

Effect of different methods of pulse width modulation on power losses in an induction motor

Science.gov (United States)

Gulyaev, Alexander; Fokin, Dmitrii; Shuharev, Sergey; Ten, Evgenii

2017-10-01

We consider the calculation of modulation power losses in a system “induction motor-inverter” for various pulse width modulation (PWM) methods of the supply voltage. Presented values of modulation power losses are the result of modeling a system “DC link - two-level three-phase voltage inverter - induction motor - load”. In this study the power losses in a system “induction motor - inverter” are computed, as well as losses caused by higher harmonics of PWM supply voltage, followed by definition of active power consumed by the DC link for a specified value mechanical power on the induction motor shaft. Mechanical power was determined by the rotation speed and the torque on the motor shaft in various quasi-sinusoidal supply voltage PWM modes. These calculations reveal the best coefficient of performance (COP) in a system of a variable frequency drive (VFD) with independent voltage inverter controlled by induction motor PWM.

Lifetime prediction of high-power press-pack IGBTs in wind power applications

DEFF Research Database (Denmark)

Busca, Cristian

The Wind Turbine (WT) industry is advancing at a rapid pace and the power rating of new WTs is continuously growing. The next generation large WTs are likely to be realized with full-scale power converters due to the advantages they offer in terms of grid code compliance, power density and decoup......The Wind Turbine (WT) industry is advancing at a rapid pace and the power rating of new WTs is continuously growing. The next generation large WTs are likely to be realized with full-scale power converters due to the advantages they offer in terms of grid code compliance, power density...... and decoupling of the generator and grid sides. Press-Pack (PP) Insulated Gate Bipolar Transistors (IGBTs) are promising semiconductor devices for the next generation large WTs due to the advantages they offer in terms of power capability, power density and thermal cycling capability. PP IGBTs require proper...

Analog Amplitude Modulation of a High Voltage, Solid State Inductive Adder, Pulse Generator Using MOSFETS

International Nuclear Information System (INIS)

Gower, E J; Sullivan, J S

2002-01-01

High voltage, solid state, inductive adder, pulse generators have found increasing application as fast kicker pulse modulators for charged particle beams. The solid state, inductive adder, pulse generator is similar in operation to the linear induction accelerator. The main difference is that the solid state, adder couples energy by transformer action from multiple primaries to a voltage summing stalk, instead of an electron beam. Ideally, the inductive adder produces a rectangular voltage pulse at the load. In reality, there is usually some voltage variation at the load due to droop on primary circuit storage capacitors, or, temporal variations in the load impedance. Power MOSFET circuits have been developed to provide analog modulation of the output voltage amplitude of a solid state, inductive adder, pulse generator. The modulation is achieved by including MOSFET based, variable subtraction circuits in the multiple primary stack. The subtraction circuits can be used to compensate for voltage droop, or, to tailor the output pulse amplitude to provide a desired effect in the load. Power MOSFET subtraction circuits have been developed to modulate short, temporal (60-400 ns), voltage and current pulses. MOSFET devices have been tested up to 20 amps and 800 Volts with a band pass of 50 MHz. An analog modulation cell has been tested in a five cell high, voltage adder stack

Electro-thermal Modeling for Junction Temperature Cycling-Based Lifetime Prediction of a Press-Pack IGBT 3L-NPC-VSC Applied to Large Wind Turbines

DEFF Research Database (Denmark)

Senturk, Osman Selcuk; Munk-Nielsen, Stig; Teodorescu, Remus

2011-01-01

Reliability is a critical criterion for multi-MW wind turbines, which are being employed with increasing numbers in wind power plants, since they operate under harsh conditions and have high maintenance cost due to their remote locations. In this study, the wind turbine grid-side converter...... reliability is investigated regarding IGBT lifetime based on junction temperature cycling for the grid-side press-pack IGBT 3L-NPC-VSC, which is a state-of-the art high reliability solution. In order to acquire IGBT junction temperatures for given wind power profiles and to use them in IGBT lifetime...... prediction, the converter electro-thermal model including electrical, power loss, and dynamical thermal models is developed with the main focus on the thermal modeling regarding converter topology, switch technology, and physical structure. Moreover, these models are simplified for their practical...

One Curve Embedded Full-Bridge MMC Modeling Method with Detailed Representation of IGBT Characteristics

Science.gov (United States)

Hongyang, Yu; Zhengang, Lu; Xi, Yang

2017-05-01

Modular Multilevel Converter is more and more widely used in high voltage DC transmission system and high power motor drive system. It is a major topological structure for high power AC-DC converter. Due to the large module number, the complex control algorithm, and the high power user’s back ground, the MMC model used for simulation should be as accurate as possible to simulate the details of how MMC works for the dynamic testing of the MMC controller. But so far, there is no sample simulation MMC model which can simulate the switching dynamic process. In this paper, one curve embedded full-bridge MMC modeling method with detailed representation of IGBT characteristics is proposed. This method is based on the switching curve referring and sample circuit calculation, and it is sample for implementation. Based on the simulation comparison test under Matlab/Simulink, the proposed method is proved to be correct.

Efficiency Evaluation on a CoolMos Switching and IGBT Conducting Multilevel Inverter

DEFF Research Database (Denmark)

Anthon, Alexander; Zhang, Zhe; Andersen, Michael A. E.

2015-01-01

This paper deals with a three-level inverter topology in the 3 kW range as an alternative to commonly used three-level topologies. The topology is attractive for having low switching losses due to the utilization of CoolMos switching devices while keeping conduction losses low due to the utilizat......This paper deals with a three-level inverter topology in the 3 kW range as an alternative to commonly used three-level topologies. The topology is attractive for having low switching losses due to the utilization of CoolMos switching devices while keeping conduction losses low due...... to the utilization of IGBTs. A proper time delay between the CoolMos and IGBT devices increases the efficiency by 0.2%. Maximum efficiencies of 97.7 % are achieved and less than 0.2 % efficiency degradation is possible with doubled switching frequency. The case temperatures of the switching devices are below 60 ◦C...

Advanced Accelerated Power Cycling Test for Reliability Investigation of Power Device Modules

DEFF Research Database (Denmark)

Choi, Uimin; Jørgensen, Søren; Blaabjerg, Frede

2016-01-01

This paper presents an apparatus and methodology for an advanced accelerated power cycling test of insulated-gate bipolar transistor (IGBT) modules. In this test, the accelerated power cycling test can be performed under more realistic electrical operating conditions with online wear-out monitoring...... of tested power IGBT module. The various realistic electrical operating conditions close to real three-phase converter applications can be achieved by the simple control method. Further, by the proposed concept of applying the temperature stress, it is possible to apply various magnitudes of temperature...... swing in a short cycle period and to change the temperature cycle period easily. Thanks to a short temperature cycle period, test results can be obtained in a reasonable test time. A detailed explanation of apparatus such as configuration and control methods for the different functions of accelerated...

Converter Monitoring Unit for Retrofit of Wind Power Converters

DEFF Research Database (Denmark)

Rannestad, Bjorn; Maarbjerg, Anders Eggert; Frederiksen, Kristian

2018-01-01

A Converter Monitoring Unit (CMU), which will enable condition monitoring of wind turbine converters is presented in this paper. Reducing the cost of corrective maintenance by means of condition monitoring is a way of lowering Operation & Maintenance (O&M) costs for wind turbine systems....... The CMU must be able to detect a broad range of failure modes related to Insulated Gate Bipolar Transistor (IGBT) power modules and associated gate drives. IGBT collector-emitter on-state voltage (vceon) and current (ic) is sampled in the CMU and used for detection of emerging failures. A new method...... for compensation of unwanted inductive voltage drop in the vceon measurement path is presented, enabling retrofitting of CMUs in existing wind turbines. Finally, experimental results obtained on a prototype CMU are presented. Experimentally the vceon dependency to IGBT junction temperature and deterioration...

Performance analysis of variable speed multiphase induction motor with pole phase modulation

Directory of Open Access Journals (Sweden)

Liu Huijuan

2016-09-01

Full Text Available The pole phase modulation (PPM technique is an effective method to extend speed range and torque capabilities for an integrated starter and hybrid electric vehicles applications. In this paper, the five pole-phase combination types of a multiphase induction motor (IM with 36 stator slots and 36 stator conductors are presented and compared quantitatively by using the time-stepping finite element method (TS-FEM. The 36 stator conductors of the proposed multiphase IM are fed by a 36 leg inverter and the current phase angle and amplitude of each stator conductor can be controlled independently. This paper focuses on the winding connection, the PPM technique and the performance comparative analysis of each pole-phase combination types of the proposed multiphase IM. The flux distribution, air-gap flux density, output torque, core losses and efficiency of five pole-phase combination types have been investigated.

A 5 kA pulsed power supply for inductive and plasma loads in large volume plasma device

Energy Technology Data Exchange (ETDEWEB)

Srivastava, P. K., E-mail: pkumar@ipr.res.in; Singh, S. K.; Sanyasi, A. K.; Awasthi, L. M., E-mail: kushagra.lalit@gmail.com; Mattoo, S. K. [Institute for Plasma Research, Gandhinagar (India)

2016-07-15

This paper describes 5 kA, 12 ms pulsed power supply for inductive load of Electron Energy Filter (EEF) in large volume plasma device. The power supply is based upon the principle of rapid sourcing of energy from the capacitor bank (2.8 F/200 V) by using a static switch, comprising of ten Insulated Gate Bipolar Transistors (IGBTs). A suitable mechanism is developed to ensure equal sharing of current and uniform power distribution during the operation of these IGBTs. Safe commutation of power to the EEF is ensured by the proper optimization of its components and by the introduction of over voltage protection (>6 kV) using an indigenously designed snubber circuit. Various time sequences relevant to different actions of power supply, viz., pulse width control and repetition rate, are realized through optically isolated computer controlled interface.

Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

International Nuclear Information System (INIS)

Reghu, T.; Mandloi, V.; Shrivastava, Purushottam

2014-01-01

Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J

Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

Science.gov (United States)

Reghu, T.; Mandloi, V.; Shrivastava, Purushottam

2014-05-01

Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J.

Development of a 33 kV, 20 A long pulse converter modulator for high average power klystron

Energy Technology Data Exchange (ETDEWEB)

Reghu, T.; Mandloi, V.; Shrivastava, Purushottam [Pulsed High Power Microwave Section, Raja Ramanna Centre for Advanced Technology, Indore 452013, M.P. (India)

2014-05-15

Research, design, and development of high average power, long pulse modulators for the proposed Indian Spallation Neutron Source are underway at Raja Ramanna Centre for Advanced Technology. With this objective, a prototype of long pulse modulator capable of delivering 33 kV, 20 A at 5 Hz repetition rate has been designed and developed. Three Insulated Gate Bipolar Transistors (IGBT) based switching modules driving high frequency, high voltage transformers have been used to generate high voltage output. The IGBT based switching modules are shifted in phase by 120° with respect to each other. The switching frequency is 25 kHz. Pulses of 1.6 ms pulse width, 80 μs rise time, and 70 μs fall time have been achieved at the modulator output. A droop of ±0.6% is achieved using a simple segmented digital droop correction technique. The total fault energy transferred to the load during fault has been measured by conducting wire burn tests and is found to be within 3.5 J.

Switching speed limitations of high power IGBT modules

DEFF Research Database (Denmark)

Incau, Bogdan Ioan; Trintis, Ionut; Munk-Nielsen, Stig

2015-01-01

for the blocking dc-link voltage. Switching losses are analyzed upon a considerable variation of resistor value from turn-on gate driver side. Short circuit operations are investigated along with safe operating area for entire module to validate electrical capabilities under extreme conditions....

Combinatorial Dyson-Schwinger equations and inductive data types

Science.gov (United States)

Kock, Joachim

2016-06-01

The goal of this contribution is to explain the analogy between combinatorial Dyson-Schwinger equations and inductive data types to a readership of mathematical physicists. The connection relies on an interpretation of combinatorial Dyson-Schwinger equations as fixpoint equations for polynomial functors (established elsewhere by the author, and summarised here), combined with the now-classical fact that polynomial functors provide semantics for inductive types. The paper is expository, and comprises also a brief introduction to type theory.

Thyratron-PFN, IGBT Hybrid, and Direct Switched Modulator R and D As it Effects Klystron Protection

International Nuclear Information System (INIS)

Gold, Saul L

2000-01-01

Modulator development is an ongoing program at SLAC. The Stanford Linear Accelerator with its approximately 240 klystrons and modulators operates for 6,000 plus hours a year. This operation gives SLAC an important insight into component and system reliability in the High Voltage environment. The planned NLC is approximately 10 times the size of SLAC and the High Voltage Modulator Klystron systems are one of the largest cost drivers. This paper will contain a brief progress report on the optimized Line Modulator and touch on Solid-State advances, which make Solid State, High Power pulse modulators the wave of the future. Klystron protection remains a critical issue along with modulator reliability, efficiency and cost. Configurations whereby multiple klystrons are paralleled on a single modulator may exacerbate the problem. The majority of this paper will discuss tests at SLAC of klystron arcs on Line-type modulators with single and double klystron loads. This talk may introduce and refer to other talks at this conference and other conferences by National and Foreign Laboratory collaborators and Industry, specifically in relation to DOE SBIR programs

Controller Design for Direct Torque Controlled Space Vector Modulated (DTC-SVM) Induction Motor Drives

DEFF Research Database (Denmark)

Zelechowski, M.; Kazmierkowski, M.P.; Blaabjerg, Frede

2005-01-01

In this paper two different methods of PI controllers for direct torque controlled-space vector modulated induction motor drives have been studied. The first one is simple method based only on symmetric optimum criterion. The second approach takes into account the full model of induction motor in...

Solid-state pulse modulator for a 1.7-MW X-band magnetron

International Nuclear Information System (INIS)

Choi, Jaegu; Shin, Yongmoon; Choi, Youngwook; Kim, Kwanho

2014-01-01

Medical linear accelerators (LINAC) for cancer treatment require pulse modulators to generate high-power pulses with a fast rise time, flat top and short duration to drive high-power magnetrons. Solid-state pulse modulators (SSPM) for medical LINACs that use high power semiconductor switches with high repetition rates, high stability and long lifetimes have been introduced to replace conventional linear-type pulse generators that use gaseous discharge switches. In this paper, the performance of a developed SSPM, which mainly consists of a capacitor charger, an insulated-gate bipolar transistor (IGBT) - capacitor stack and a pulse transformer, is evaluated with a dummy load and an X-band magnetron load. A theoretical analysis of the pulse transformer, which is a critical element of the SSPM, is carried out. The output pulse has a fast rise time and low droop, such that the modulator can drive the X-band magnetron.

A Multi-Cycle Q-Modulation for Dynamic Optimization of Inductive Links.

Science.gov (United States)

Lee, Byunghun; Yeon, Pyungwoo; Ghovanloo, Maysam

2016-08-01

This paper presents a new method, called multi-cycle Q-modulation, which can be used in wireless power transmission (WPT) to modulate the quality factor (Q) of the receiver (Rx) coil and dynamically optimize the load impedance to maximize the power transfer efficiency (PTE) in two-coil links. A key advantage of the proposed method is that it can be easily implemented using off-the-shelf components without requiring fast switching at or above the carrier frequency, which is more suitable for integrated circuit design. Moreover, the proposed technique does not need any sophisticated synchronization between the power carrier and Q-modulation switching pulses. The multi-cycle Q-modulation is analyzed theoretically by a lumped circuit model, and verified in simulation and measurement using an off-the-shelf prototype. Automatic resonance tuning (ART) in the Rx, combined with multi-cycle Q-modulation helped maximizing PTE of the inductive link dynamically in the presence of environmental and loading variations, which can otherwise significantly degrade the PTE in multi-coil settings. In the prototype conventional 2-coil link, the proposed method increased the power amplifier (PA) plus inductive link efficiency from 4.8% to 16.5% at ( R L = 1 kΩ, d 23 = 3 cm), and from 23% to 28.2% at ( R L = 100 Ω, d 23 = 3 cm) after 11% change in the resonance capacitance, while delivering 168.1 mW to the load (PDL).

Crowbar System in Doubly Fed Induction Wind Generators

Directory of Open Access Journals (Sweden)

Maurício B. C. Salles

2010-04-01

Full Text Available In the last 15 years, the use of doubly fed induction machines in modern variable-speed wind turbines has increased rapidly. This development has been driven by the cost reduction as well as the low-loss generation of Insulated Gate Bipolar Transistors (IGBT. According to new grid code requirements, wind turbines must remain connected to the grid during grid disturbances. Moreover, they must also contribute to voltage support during and after grid faults. The crowbar system is essential to avoid the disconnection of the doubly fed induction wind generators from the network during faults. The insertion of the crowbar in the rotor circuits for a short period of time enables a more efficient terminal voltage control. As a general rule, the activation and the deactivation of the crowbar system is based only on the DC-link voltage level of the back-to-back converters. In this context, the authors discuss the critical rotor speed to analyze the instability of doubly fed induction generators during grid faults.

Modeling And Simulation Of Highly Advanced Multilevel Inverter For Speed Control Of Induction Motor

Directory of Open Access Journals (Sweden)

Ravi Raj

2017-02-01

Full Text Available In this Paper the problem of removing Power dissipation from single phase Induction Motor with DC sources is considered by the speed control of Induction Motor with highly advanced 9-Level multi-level Inverter which having approximate zero Harmonics. As the demand of power is increasing day by day. So that we must introduced very advanced Electrical Instruments which having high efficiency and less dissipation of power. The requirement of very advanced Inverter is necessary. Here we are designing a Multi-level Inverter up to the 9-level using IGBT Insulated-gate bipolar transistor by Mat lab which having negligible total harmonic distortion THD thats why it will control the speed of single phase Induction motor which is presently widely used in our daily needs. Also several informative Simulation results verify the authority and truthiness of the proposed Model.

Robust position control of induction motor using fuzzy logic control

International Nuclear Information System (INIS)

Kim, Sei Chan; Kim, Duk Hun; Yang, Seung Ho; Won, Chung Yuen

1993-01-01

In recent years, fuzzy logic or fuzzy set theory has reveived attention of a number of researchers in the area of power electronics and motion control. The paper describes a vector-controlled induction motor position servo drive where fuzzy control is used to get robustness against parameter variation and load torque disturbance effects. Both coarse and fine control with the help of look-up rule tables are used to improve transient response and system settling time. The performance characteristics are then compared with those of proportional-integral(PI) control. The simulation results clearly indicate the superiority of fuzzy control with larger number of rules. The fuzzy controller was implemented with a 16-bit microprocessor and tested in laboratory on a 3-hp IGBT inverter induction motor drive system. The test results verify the simulation performance. (Author)

Discontinuous interleaving of parallel inverters for efficiency improvement

DEFF Research Database (Denmark)

Rannestad, Bjørn; Munk-Nielsen, Stig; Gadgaard, Kristian

2017-01-01

Interleaved switching of parallel inverters has previously been proposed for efficiency/size improvements of grid connected three-phase inverters. This paper proposes a novel interleaving method which practically eliminates insulated gate bipolar transistor (IGBT) turn-on losses and drastically...... overall power module losses are reduced. The modulation strategy is suited for converters with doubly fed induction generators (DFIG) for wind turbines, but are not limited hereto. Improvement of switching performance are measured and operational efficiency improvements are calculated and verified...

Prefrontal and parietal activity is modulated by the rule complexity of inductive reasoning and can be predicted by a cognitive model.

Science.gov (United States)

Jia, Xiuqin; Liang, Peipeng; Shi, Lin; Wang, Defeng; Li, Kuncheng

2015-01-01

In neuroimaging studies, increased task complexity can lead to increased activation in task-specific regions or to activation of additional regions. How the brain adapts to increased rule complexity during inductive reasoning remains unclear. In the current study, three types of problems were created: simple rule induction (i.e., SI, with rule complexity of 1), complex rule induction (i.e., CI, with rule complexity of 2), and perceptual control. Our findings revealed that increased activations accompany increased rule complexity in the right dorsal lateral prefrontal cortex (DLPFC) and medial posterior parietal cortex (precuneus). A cognitive model predicted both the behavioral and brain imaging results. The current findings suggest that neural activity in frontal and parietal regions is modulated by rule complexity, which may shed light on the neural mechanisms of inductive reasoning. Copyright © 2014. Published by Elsevier Ltd.

Low-inductance switch and capacitor energy storage modules made of packages of industrial condensers IK50-3

International Nuclear Information System (INIS)

Bykov, Yu A; Krastelev, E G; Sedin, A A; Feduschak, V F

2017-01-01

A low-inductance module of a high-current capacitive energy storage with an operating voltage of 40 kV is developed. The design of the module is based on the application of capacitive sections of the industrial condenser IK50-3. The module includes two capacitors of 0.35 μF each, one common low-jitter triggered gas switch and 2 groups of output cables of 4 from each capacitor. A bus bars topology developed for the switch and cables connections provides a small total inductance of the discharge circuit, for the module with the output cables KVIM of 0.5 m long, it is lower than 40 nH. The set of 10 modules is now used for driving the 20 stages linear transformer for a fast charging of the pulse forming line of the high-current nanosecond accelerator. A design of the module and the results of tests of a single module and a set of 10 are presented. (paper)

The negative differential resistance characteristics of an RC-IGBT and its equivalent circuit model

International Nuclear Information System (INIS)

Zhang Wenliang; Zhu Yangjun; Tian Xiaoli; Lu Shuojin

2014-01-01

A simple equivalent circuit model is proposed according to the device structure of reverse conducting insulated gate bipolar transistors (RC-IGBT). Mathematical derivation and circuit simulations indicate that this model can explain the snap-back effect (including primary snap-back effect, secondary snap-back effect, and reverse snap-back effect) and hysteresis effect perfectly. (semiconductor devices)

Higher Inductive Types as Homotopy-Initial Algebras

Science.gov (United States)

2016-08-01

correspondence between Martin -Löf’s constructive type theory and ab- stract homotopy theory. We have a powerful interplay between these disciplines - we can...inductive types we call W-quotients which generalize Martin -Löf’s well-founded trees to a higher- dimensional setting. We have shown that a...27]). Among the most studied type theories is Martin -Löf’s intuition- istic type theory ([20, 22]), also known as constructive or dependent type

Design, status and first operations of the spallation neutron source polyphase resonant converter modulator system

Energy Technology Data Exchange (ETDEWEB)

Reass, W. A. (William A.); Apgar, S. E. (Sean E.); Baca, D. M. (David M.); Doss, James D.; Gonzales, J. (Jacqueline); Gribble, R. F. (Robert F.); Hardek, T. W. (Thomas W.); Lynch, M. T. (Michael T.); Rees, D. E. (Daniel E.); Tallerico, P. J. (Paul J.); Trujillo, P. B. (Pete B.); Anderson, D. E. (David E.); Heidenreich, D. A. (Dale A.); Hicks, J. D. (Jim D.); Leontiev, V. N.

2003-01-01

The Spallation Neutron Source (SNS) is a new 1.4 MW average power beam, 1 GeV accelerator being built at Oak Ridge National Laboratory. The accelerator requires 15 converter-modulator stations each providing between 9 and 11 MW pulses with up to a 1 .I MW average power. The converter-modulator can be described as a resonant 20 kHz polyphase boost inverter. Each converter modulator derives its buss voltage from a standard substation cast-core transformer. Each substation is followed by an SCR pre-regulator to accommodate voltage changes from no load to full load, in addition to providing a soft-start function. Energy storage is provided by self-clearing metallized hazy polypropylene traction capacitors. These capacitors do not fail short, but clear any internal anomaly. Three 'H-Bridge' IGBT transistor networks are used to generate the polyphase 20 kHz transformer primary drive waveforms. The 20 kHz drive waveforms are time-gated to generate the desired klystron pulse width. Pulse width modulation of the individual 20 lcHz pulses is utilized to provide regulated output waveforms with DSP based adaptive feedforward and feedback techniques. The boost transformer design utilizes nanocrystalline alloy that provides low core loss at design flux levels and switching frequencies. Capacitors are used on the transformer secondary networks to resonate the leakage inductance. The transformers are wound for a specific leakage inductance, not turns ratio. This design technique generates multiple secondary volts per turn as compared to the primary. With the appropriate tuning conditions, switching losses are minimized. The resonant topology has the added benefit of being deQed in a klystron fault condition, with little energy deposited in the arc. This obviates the need of crowbars or other related networks. A review of these design parameters, operational performance, production status, and OWL installation and performance to date will be presented.

Design, status and first operations of the spallation neutron source polyphase resonant converter modulator system

International Nuclear Information System (INIS)

Reass, W.A.; Apgar, S.E.; Baca, D.M.; Doss, James D.; Gonzales, J.; Gribble, R.F.; Hardek, T.W.; Lynch, M.T.; Rees, D.E.; Tallerico, P.J.; Trujillo, P.B.; Anderson, D.E.; Heidenreich, D.A.; Hicks, J.D.; Leontiev, V.N.

2003-01-01

The Spallation Neutron Source (SNS) is a new 1.4 MW average power beam, 1 GeV accelerator being built at Oak Ridge National Laboratory. The accelerator requires 15 converter-modulator stations each providing between 9 and 11 MW pulses with up to a 1 .I MW average power. The converter-modulator can be described as a resonant 20 kHz polyphase boost inverter. Each converter modulator derives its buss voltage from a standard substation cast-core transformer. Each substation is followed by an SCR pre-regulator to accommodate voltage changes from no load to full load, in addition to providing a soft-start function. Energy storage is provided by self-clearing metallized hazy polypropylene traction capacitors. These capacitors do not fail short, but clear any internal anomaly. Three 'H-Bridge' IGBT transistor networks are used to generate the polyphase 20 kHz transformer primary drive waveforms. The 20 kHz drive waveforms are time-gated to generate the desired klystron pulse width. Pulse width modulation of the individual 20 lcHz pulses is utilized to provide regulated output waveforms with DSP based adaptive feedforward and feedback techniques. The boost transformer design utilizes nanocrystalline alloy that provides low core loss at design flux levels and switching frequencies. Capacitors are used on the transformer secondary networks to resonate the leakage inductance. The transformers are wound for a specific leakage inductance, not turns ratio. This design technique generates multiple secondary volts per turn as compared to the primary. With the appropriate tuning conditions, switching losses are minimized. The resonant topology has the added benefit of being deQed in a klystron fault condition, with little energy deposited in the arc. This obviates the need of crowbars or other related networks. A review of these design parameters, operational performance, production status, and OWL installation and performance to date will be presented.

A new method for compensation of the effect of charging transformer's leakage inductance on PFN voltage regulation in Klystron pulse modulators

Energy Technology Data Exchange (ETDEWEB)

Patel, Akhil, E-mail: akhilpatel@rrcat.gov.in; Kale, Umesh; Shrivastava, Purushottam

2017-04-21

The Line type modulators have been widely used to generate high voltage rectangular pulses to power the klystron for high power RF generation. In Line type modulator, the Pulse Forming Network (PFN) which is a cascade combination of lumped capacitors and inductors is used to store the electrical energy. The charged PFN is then discharged into a klystron by firing a high voltage Thyratron switch. This discharge generates a high voltage rectangular pulse across the klystron electrodes. The amplitude and phase of Klystron's RF output is governed by the high voltage pulse amplitude. The undesired RF amplitude and phase stability issues arises at the klystron's output due to inter-pulse and during the pulse amplitude variations. To reduce inter-pulse voltage variations, the PFN is required to be charged at the same voltage after every discharge cycle. At present, the combination of widely used resonant charging and deQing method is used to regulate the pulse to pulse PFN voltage variations but the charging transformer's leakage inductance puts an upper bound on the regulation achievable by this method. Here we have developed few insights of the deQing process and devised a new compensation method to compensate this undesired effect of charging transformer's leakage inductance on the pulse to pulse PFN voltage stability. This compensation is accomplished by the controlled partial discharging of the split PFN capacitor using a low voltage MOSFET switch. Theoretically, very high values of pulse to pulse voltage stability may be achieved using this method. This method may be used in deQing based existing modulators or in new modulators, to increase the pulse to pulse voltage stability, without having a very tight bound on charging transformer's leakage inductance. Given a stable charging power supply, this method may be used to further enhance the inter-pulse voltage stability of modulators which employ the direct charging, after replacing the

Power module assembly with reduced inductance

Energy Technology Data Exchange (ETDEWEB)

Ward, Terence G.; Stancu, Constantin C.; Jaksic, Marko; Mann, Brooks S.

2018-03-13

A power module assembly has a plurality of electrically conducting layers, including a first layer and a third layer. One or more electrically insulating layers are operatively connected to each of the plurality of electrically conducting layers. The electrically insulating layers include a second layer positioned between and configured to electrically isolate the first and the third layers. The first layer is configured to carry a first current flowing in a first direction. The third layer is configured to carry a second current flowing in a second direction opposite to the first direction, thereby reducing an inductance of the assembly. The electrically insulating layers may include a fourth layer positioned between and configured to electrically isolate the third layer and a fifth layer. The assembly results in a combined substrate and heat sink structure. The assembly eliminates the requirements for connections between separate substrate and heat sink structures.

Approaching Repetitive Short Circuit Tests on MW-Scale Power Modules by means of an Automatic Testing Setup

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Wang, Huai; Iannuzzo, Francesco

2016-01-01

An automatic testing system to perform repetitive short-circuit tests on megawatt-scale IGBT power modules is pre-sented and described in this paper, pointing out the advantages and features of such testing approach. The developed system is based on a non-destructive short-circuit tester, which has...

A Study of Mach-Zehnder Interferometer Type Optical Modulator Applicable to an Accelerometer

Science.gov (United States)

Suzuki, Masato; Takahashi, Tomokazu; Aoyagi, Seiji; Amemiya, Yoshiteru; Fukuyama, Masataka; Yokoyama, Shin

2011-04-01

A novel Mach-Zehnder interferometer (MZI)-type optical modulator based on micro electro mechanical systems (MEMS) technology is developed in this study. In this optical modulator, one of two branched waveguides in the MZI has a floating beam structure (air-bridge type). Additionally, a cantilever supporting a proof mass intersects with the floating optical waveguide. When an inertial force due to acceleration is applied to the proof mass, the floating waveguide is expanded and the output of the MZI is modulated. Therefore, this optical modulator will be applicable to an accelerometer in the future. To decrease optical loss at the intersectional point between the floating waveguide and the cantilever in the MZI, the multi-mode interference (MMI) waveguide is serially connected with the floating waveguide and the cantilever crosses to the MMI waveguide. An optimization of the MMI waveguide and an estimation of deflection of the floating waveguide due to applying force are carried out by using optical and mechanical simulation, respectively. The proposed optical modulator is fabricated by inductively coupled plasma (ICP) etching of the top layer of a silicon-on-insulator (SOI) wafer, which is made of crystal Si. The floating waveguide in the modulator is formed by removal of its underlying buried oxide (BOX) layer of SOI. As a result of evaluation, we have succeeded in changing the output of the MZI by applying a force to the cantilever. However, the modulation is smaller than the expected value. Improvement of the modulation and detection of the inertial force due to the applied acceleration are future tasks.

IR Camera Validation of IGBT Junction Temperature Measurement via Peak Gate Current

DEFF Research Database (Denmark)

Baker, Nick; Dupont, Laurent; Munk-Nielsen, Stig

2017-01-01

partial bond-wire lift-off. Results are also compared with a traditional electrical temperature measurement method: the voltage drop under low current (VCE(low)). In all cases, the IGPeak method is found to provide a temperature slightly overestimating the temperature of the gate pad. Consequently, both...... the gate pad position and chip temperature distribution influence whether the measurement is representative of the mean junction temperature. These results remain consistent after chips are degraded through bondwire lift-off. In a paralleled IGBT configuration with non-negligible temperature disequilibrium...

The Analysis Of Accuracy Of Selected Methods Of Measuring The Thermal Resistance Of IGBTs

Directory of Open Access Journals (Sweden)

Górecki Krzysztof

2015-09-01

Full Text Available In the paper selected methods of measuring the thermal resistance of an IGBT (Insulated Gate Bipolar Transistor are presented and the accuracy of these methods is analysed. The analysis of the measurement error is performed and operating conditions of the considered device, at which each measurement method assures the least measuring error, are pointed out. Theoretical considerations are illustrated with some results of measurements and calculations.

Power module packaging with double sided planar interconnection and heat exchangers

Science.gov (United States)

Liang, Zhenxian; Marlino, Laura D.; Ning, Puqi; Wang, Fei

2015-05-26

A double sided cooled power module package having a single phase leg topology includes two IGBT and two diode semiconductor dies. Each IGBT die is spaced apart from a diode semiconductor die, forming a switch unit. Two switch units are placed in a planar face-up and face-down configuration. A pair of DBC or other insulated metallic substrates is affixed to each side of the planar phase leg semiconductor dies to form a sandwich structure. Attachment layers are disposed on outer surfaces of the substrates and two heat exchangers are affixed to the substrates by rigid bond layers. The heat exchangers, made of copper or aluminum, have passages for carrying coolant. The power package is manufactured in a two-step assembly and heating process where direct bonds are formed for all bond layers by soldering, sintering, solid diffusion bonding or transient liquid diffusion bonding, with a specially designed jig and fixture.

Parameter Extraction for PSpice Models by means of an Automated Optimization Tool – An IGBT model Study Case

DEFF Research Database (Denmark)

Suárez, Carlos Gómez; Reigosa, Paula Diaz; Iannuzzo, Francesco

2016-01-01

An original tool for parameter extraction of PSpice models has been released, enabling a simple parameter identification. A physics-based IGBT model is used to demonstrate that the optimization tool is capable of generating a set of parameters which predicts the steady-state and switching behavio...

Performance Evaluation and Slip Regulation Control of an Asymmetrical Parameter Type Two-Phase Induction Motor Drive Using a Three-Leg Voltage Source Inverter

Science.gov (United States)

Piyarat, Wekin; Kinnares, Vijit

This paper presents a performance evaluation and a simple speed control method of an asymmetrical parameter type two-phase induction motor drive using a three-leg VSI (Voltage Source Inverter). The two-phase induction motor is adapted from an existing single-phase induction motor resulting in impedance unbalance between main and auxiliary windings. The unbalanced two-phase inverter outputs with orthogonal displacement based on a SPWM (Sinusoidal Pulse Width Modulation) method are controlled with appropriate amplitudes for improving the motor performance. Dynamic simulation of the proposed drive system is given. A simple speed controller based on a slip regulation method is designed. The overall system is implemented on a DSP (Digital Signal Processor) board. The validity of the proposed system is verified by simulation and experimental results.

Modelisation et simulation d'une liaison HVDC de type VSC-MMC

Science.gov (United States)

Saad, Hani Aziz

Converter [Siemens] - [Alstom]) or CTL (Cascaded Two Level topology [ABB]) has allowed to overcome existing limitations. This topology consists of several sub-modules connected in series. Each sub-module contains two IGBTs with antiparallel diodes and a capacitor that act as energy storage. The control of these IGBTs allows connecting and disconnecting the capacitor on the network. The grouping of several sub-modules in series forms an arm. From the AC side, each phase consists of two arms. Reactors are included in series with each arm in order to limit the fault current. The large number of IGBTs in MMCs creates complicated computation problems in electromagnetic transient type (EMT-type) simulation tools. Detailed MMC models include the representation of thousands of IGBT (Insulated Gate Bipolar Transistor) switches and must use small numerical integration time steps to accurately represent fast and multiple simultaneous switching events. This becomes particularly more complex for performing real-time simulations. The computational burden introduced by such models highlights the need to develop more efficient models. A current trend is based on simplified models capable of delivering sufficient accuracy for EMT-type simulations, however the validity range of such models must be carefully evaluated. The first objective of this thesis is to model HVDC-MMC transmission systems in EMT-type programs for off-line and real-time simulations. To fulfill this objective, different modelling approaches are presented, then the control system used for HVDC-MMC links is developed and finally the implementations of MMC models using both CPU (Central Processing Unit) and FPGA (Field-Programmable Gate Array) technologies for real-time simulations, are presented. The contributions are useful for researchers and engineers using transient simulation tools for modelling and analysis of power systems including HVDC-MMC. The HVDC links currently planned or constructed in France, are embedded in

Influence of coil current modulation on polycrystalline diamond film deposition by irradiation of Ar/CH4/H2 inductively coupled thermal plasmas

Science.gov (United States)

Betsuin, Toshiki; Tanaka, Yasunori; Arai, T.; Uesugi, Y.; Ishijima, T.

2018-03-01

This paper describes the application of an Ar/CH4/H2 inductively coupled thermal plasma with and without coil current modulation to synthesise diamond films. Induction thermal plasma with coil current modulation is referred to as modulated induction thermal plasma (M-ITP), while that without modulation is referred to as non-modulated ITP (NM-ITP). First, spectroscopic observations of NM-ITP and M-ITP with different modulation waveforms were made to estimate the composition in flux from the thermal plasma by measuring the time evolution in the spectral intensity from the species. Secondly, we studied polycrystalline diamond film deposition tests on a Si substrate, and we studied monocrystalline diamond film growth tests using the irradiation of NM-ITP and M-ITP. From these tests, diamond nucleation effects by M-ITP were found. Finally, following the irradiation results, we attempted to use a time-series irradiation of M-ITP and NM-ITP for polycrystalline diamond film deposition on a Si substrate. The results indicated that numerous larger diamond particles were deposited with a high population density on the Si substrate by time-series irradiation.

IGBT Switching Characteristic Curve Embedded Half-Bridge MMC Modelling and Real Time Simulation Realization

Science.gov (United States)

Zhengang, Lu; Hongyang, Yu; Xi, Yang

2017-05-01

The Modular Multilevel Converter (MMC) is one of the most attractive topologies in recent years for medium or high voltage industrial applications, such as high voltage dc transmission (HVDC) and medium voltage varying speed motor drive. The wide adoption of MMCs in industry is mainly due to its flexible expandability, transformer-less configuration, common dc bus, high reliability from redundancy, and so on. But, when the sub module number of MMC is more, the test of MMC controller will cost more time and effort. Hardware in the loop test based on real time simulator will save a lot of time and money caused by the MMC test. And due to the flexible of HIL, it becomes more and more popular in the industry area. The MMC modelling method remains an important issue for the MMC HIL test. Specifically, the VSC model should realistically reflect the nonlinear device switching characteristics, switching and conduction losses, tailing current, and diode reverse recovery behaviour of a realistic converter. In this paper, an IGBT switching characteristic curve embedded half-bridge MMC modelling method is proposed. This method is based on the switching curve referring and sample circuit calculation, and it is sample for implementation. Based on the proposed method, a FPGA real time simulation is carried out with 200ns sample time. The real time simulation results show the proposed method is correct.

Thermal management and performance evaluation of a dual bi-directional, soft-switched IGBT-based inverter for the 1st autonomous microgrid power system in Taiwan under various operating conditions

Science.gov (United States)

Chang, Tien-Chan; Fuh, Yiin-Kuen; Lu, Hong-Yi; Tu, Sheng-Xun

2016-06-01

The thermal management of the inverter system is of great importance since very high voltage/current will be switched intermittently and/or continuously and high temperature is excruciably detrimental to the service life of electronics, especially for the switching devices such as insulated gate bipolar transistor (IGBT). In this study, a newly developed dual bi-directional IGBT-based inverter in conjunction with autonomous microgrid system is investigated with particular focus on the thermal management and performance evaluation under various operation conditions. Locally enhanced heat transfer approach such as oblique orientation and heat dissipating materials are experimentally investigated. The studied inverter system is initially packaged by a galvanized steel plate (size 62 × 48 × 18 cm) and the switching power is set in the range of 0.5-3 kW. The module is operated at the switching and pulse frequencies of 60 Hz and 20 kHz, respectively. The adoption of heat dissipating material in either paste or film form had experimentally shown to possess the flexibility tailoring heat transfer performance locally. Experimental studies of heat dissipating film with various hotspot scenarios showed that the temperature difference can be appreciably reduced as much as 13.1 and 15.4 °C, respectively with facilitation of one- and two-layers of heat dissipating film. From the measurement results, the measured peak temperature is highly dominated by the thickness of heat dissipating film, showing the dominance of thickness-dependent thermal resistance and resultant heat accumulation phenomena.

Ciprofloxacin and Trimethoprim Cause Phage Induction and Virulence Modulation in Staphylococcus aureus

Science.gov (United States)

Goerke, Christiane; Köller, Johanna; Wolz, Christiane

2006-01-01

In Staphylococcus aureus strains of human origin, phages which integrate into the chromosomal gene coding for β-hemolysin (hlb) are widely distributed. Most of them encode accessory virulence determinants such as staphylokinase (sak) or enterotoxins. Here, we analyzed the effects of ciprofloxacin and trimethoprim on phage induction and expression of phage-encoded virulence factors by using isolates from patients with cystic fibrosis for which the induction of hlb-converting phages was demonstrated in vivo (C. Goerke, S. Matias y Papenberg, S. Dasbach, K. Dietz, R. Ziebach, B. C. Kahl, and C. Wolz, J. Infect. Dis. 189:724-734, 2004) as well as a φ13 lysogen of phage-cured strain 8325-4. Treatment of lysogens with subinhibitory concentrations of either antibiotic resulted in (i) delysogenization of strains resembling the isolates picked up after chronic lung infection and (ii) replication of phages in the bacterial host in a dose-dependent manner. Ciprofloxacin treatment resulted in enhanced recA transcription, indicating involvement of the SOS response in phage mobilization. Induction of φ13 was linked to elevated expression of the phage-encoded virulence gene sak, chiefly due to the activation of latent phage promoters. In summary, we could show the induction of hlb-converting phages and a subsequent virulence modulation of the host bacterium by ciprofloxacin and trimethoprim. PMID:16377683

Sadhana | Indian Academy of Sciences

Indian Academy of Sciences (India)

A commutation strategy for IGBT-based CSI-fed parallel resonant circuit for induction heating application · MOLAY ROY MAINAK SENGUPTA · More Details Abstract Fulltext PDF. A brief study on a commutation strategy for a current source inverter (CSI)-fed parallel resonant circuit, using switches formed by IGBTs with series ...

Processing and characterization of device solder interconnection and module attachment for power electronics modules

Science.gov (United States)

Haque, Shatil

This research is focused on the processing of an innovative three-dimensional packaging architecture for power electronics building blocks with soldered device interconnections and subsequent characterization of the module's critical interfaces. A low-cost approach termed metal posts interconnected parallel plate structure (MPIPPS) was developed for packaging high-performance modules of power electronics building blocks (PEBB). The new concept implemented direct bonding of copper posts, not wire bonding of fine aluminum wires, to interconnect power devices as well as joining the different circuit planes together. We have demonstrated the feasibility of this packaging approach by constructing PEBB modules (consisting of Insulated Gate Bipolar Transistors (IGBTs), diodes, and a few gate driver elements and passive components). In the 1st phase of module fabrication with IGBTs with Si3N 4 passivation, we had successfully fabricated packaged devices and modules using the MPIPPS technique. These modules were tested electrically and thermally, and they operated at pulse-switch and high power stages up to 6kW. However, in the 2nd phase of module fabrication with polyimide passivated devices, we experienced significant yield problems due to metallization difficulties of these devices. The under-bump metallurgy scheme for the development of a solderable interface involved sputtering of Ti-Ni-Cu and Cr-Cu, and an electroless deposition of Zn-Ni-Au metallization. The metallization process produced excellent yield in the case of Si3N4 passivated devices. However, under the same metallization schemes, devices with a polyimide passivation exhibited inconsistent electrical contact resistance. We found that organic contaminants such as hydrocarbons remain in the form of thin monolayers on the surface, even in the case of as-received devices from the manufacturer. Moreover, in the case of polyimide passivated devices, plasma cleaning introduced a few carbon constituents on the

5-HT4-receptors modulate induction of long-term depression but not potentiation at hippocampal output synapses in acute rat brain slices.

Directory of Open Access Journals (Sweden)

Matthias Wawra

Full Text Available The subiculum is the principal target of CA1 pyramidal cells and mediates hippocampal output to various cortical and subcortical regions of the brain. The majority of subicular pyramidal cells are burst-spiking neurons. Previous studies indicated that high frequency stimulation in subicular burst-spiking cells causes presynaptic NMDA-receptor dependent long-term potentiation (LTP whereas low frequency stimulation induces postsynaptic NMDA-receptor-dependent long-term depression (LTD. In the present study, we investigate the effect of 5-hydroxytryptamine type 4 (5-HT4 receptor activation and blockade on both forms of synaptic plasticity in burst-spiking cells. We demonstrate that neither activation nor block of 5-HT4 receptors modulate the induction or expression of LTP. In contrast, activation of 5-HT4 receptors facilitates expression of LTD, and block of the 5-HT4 receptor prevents induction of short-term depression and LTD. As 5-HT4 receptors are positively coupled to adenylate cyclase 1 (AC1, 5-HT4 receptors might modulate PKA activity through AC1. Since LTD is blocked in the presence of 5-HT4 receptor antagonists, our data are consistent with 5-HT4 receptor activation by ambient serotonin or intrinsically active 5-HT4 receptors. Our findings provide new insight into aminergic modulation of hippocampal output.

Power density investigation on the press-pack IGBT 3L-HB-VSCs applied to large wind turbine

DEFF Research Database (Denmark)

Senturk, Osman Selcuk; Munk-Nielsen, Stig; Teodorescu, Remus

2011-01-01

capabilities, DC capacitor sizes, converter cabinet volumes of the three 3LHB- VSCs utilizing press-pack IGBTs are investigated in order to quantify and compare the power densities of the 3L-HB-VSCs employed as grid-side converters. Also, the suitable transformer types for the 3L-HB-VSCs are determined......With three different DC-side and AC-side connections, the three-level H-bridge voltage source converters (3L-HB-VSCs) are alternatives to 3L neutral-point-clamped VSCs (3L-NPC-VSCs) for interfacing large wind turbines with electricity grids. In order to assess their feasibility for large wind...... turbines, they should be investigated in terms of power density, which is one of the most important design criteria for wind turbine converters due to turbine nacelle space limitation. In this study, by means of the converter electro-thermal models based on the converter characteristics, the power...

A high frequency high power IGBT inverter drive for 45 HP/16,000 rpm brushless homopolar inductor motor

Energy Technology Data Exchange (ETDEWEB)

He, J.; Lin, F. [Stone Safety Corp., Fountain Inn, SC (United States)

1995-12-31

A microprocessor-based ultra-high speed brushless homopolar inductor motor drive system (HiDrive) with no gearing and using a high frequency IGBT inverter switching at 32 kHz is described and discussed in this paper. The homopolar motor features a solid steel rotor without magnets, windings, or laminations, which allows the motor to be operated at very high speed. The HiDrive system achieves 16,000 RPM, 45 Hp continuously. The drive system discussed in this paper can be used to replace conventional motors and speed increasing gear boxes in very high speed industrial applications such as centrifuges, compressors, blowers, pumps, and machine tool spindles. The HiDrive system discussed in this paper is used to drive a compressor for nuclear power application. In this paper, the detailed descriptions of the motor construction, equivalent circuit, operation and control principle are offered. The IGBT inverter drive system design and controls including motor speed sensing, load angle control, synchronization, brake control, power device switchings, and thermal issues are addressed. The simulation results various test results, and the typical application examples of the high speed drives are also presented in this paper.

A high frequency high power IGBT inverter drive for 45 HP/16,000 rpm brushless homopolar inductor motor

International Nuclear Information System (INIS)

He, J.; Lin, F.

1995-01-01

A microprocessor-based ultra-high speed brushless homopolar inductor motor drive system (HiDrive) with no gearing and using a high frequency IGBT inverter switching at 32 kHz is described and discussed in this paper. The homopolar motor features a solid steel rotor without magnets, windings, or laminations, which allows the motor to be operated at very high speed. The HiDrive system achieves 16,000 RPM, 45 Hp continuously. The drive system discussed in this paper can be used to replace conventional motors and speed increasing gear boxes in very high speed industrial applications such as centrifuges, compressors, blowers, pumps, and machine tool spindles. The HiDrive system discussed in this paper is used to drive a compressor for nuclear power application. In this paper, the detailed descriptions of the motor construction, equivalent circuit, operation and control principle are offered. The IGBT inverter drive system design and controls including motor speed sensing, load angle control, synchronization, brake control, power device switchings, and thermal issues are addressed. The simulation results various test results, and the typical application examples of the high speed drives are also presented in this paper

Effect of Short-Circuit Faults in the Back-to-Back Power Electronic Converter and Rotor Terminals on the Operational Behavior of the Doubly-Fed Induction Generator Wind Energy Conversion System

Directory of Open Access Journals (Sweden)

Dimitrios G. Giaourakis

2015-02-01

Full Text Available This paper deals with the operational behavior of the Doubly-Fed Induction Generator Wind Energy Conversion System under power electronic converter and rotor terminals faulty conditions. More specifically, the effect of the short-circuit fault both in one IGBT of the back-to-back power electronic converter and in rotor phases on the overall system behavior has been investigated via simulation using a system of 2 MW. Finally, the consequences of these faults have been evaluated.

On the malfunction of disk-type induction relay under seismic condition

International Nuclear Information System (INIS)

Fujita, T.; Shibata, H.; Koizumi, T.

1985-01-01

This paper deals with the malfunction of disk-type induction relay. Equations of motion for rotational movement of induction relay was formulated and the dynamic behavior was simulated under various kind of exciting conditions. Experimental verification was also performed using two dimensional shaker table for some actual relays. Sufficient agreement was recognized between experimental and analytical results and consequently the most critical reason to cause the malfunction was pointed out. (orig.)

Antibody induction versus placebo, no induction, or another type of antibody induction for liver transplant recipients

DEFF Research Database (Denmark)

Penninga, Luit; Wettergren, André; Wilson, Colin H

2014-01-01

. All 19 trials were with high risk of bias. Of the 19 trials, 16 trials were two-arm trials, and three trials were three-arm trials. Hence, we found 25 trial comparisons with antibody induction agents: interleukin-2 receptor antagonist (IL-2 RA) versus no induction (10 trials with 1454 participants....... Furthermore, serum creatinine was statistically significantly higher when T-cell specific antibody induction was compared with no induction (MD 3.77 μmol/L, 95% CI 0.33 to 7.21; low-quality evidence), as well as when polyclonal T-cell specific antibody induction was compared with no induction, but this small...... T-cell specific antibody induction, drug-related adverse events were less common among participants treated with interleukin-2 receptor antagonists (RR 0.23, 95% CI 0.09 to 0.63; low-quality evidence), but this was caused by the results from one trial, and trial sequential analysis could not exclude...

Thiazolidinediones inhibit TNFα induction of PAI-1 independent of PPARγ activation

International Nuclear Information System (INIS)

Liu, H.B.; Hu, Y.S.; Medcalf, R.L.; Simpson, R.W.; Dear, A.E.

2005-01-01

Increased plasminogen activator inhibitor type 1 (PAI-1) levels are observed in endothelial cells stimulated by tumour necrosis factor α (TNFα). Thiazolidinediones (TZDs) may inhibit elevated endothelial cell PAI-1 accounting, in part, for the putative atheroprotective effects of TZDs. In an endothelial cell line, Rosiglitazone (RG) and Pioglitazone (PG) inhibited induction of PAI-1 by TNFα. The specific peroxisome proliferator-activated receptor γ (PPARγ) inhibitor, SR-202, failed to modulate this effect. RG also inhibited the effect of TNFα on a reporter gene construct harbouring the proximal PAI-1 promoter and PAI-1 mRNA in cells co-transfected with a dominant-negative PPARγ construct. RG and PG attenuated TNFα-mediated induction of trans-acting factor(s) Nur77/Nurr1 and binding of nuclear proteins (NP) to the cis-acting element (NBRE). SR-202 failed to modulate these effects. The observations suggest TZDs inhibit TNFα-mediated PAI-1 induction independent of inducible PPARγ activation and this may involve in the modulation of Nur77/Nurr1 expression and NP binding to the PAI-1 NBRE

Induction of specific neuron types by overexpression of single transcription factors.

Science.gov (United States)

Teratani-Ota, Yusuke; Yamamizu, Kohei; Piao, Yulan; Sharova, Lioudmila; Amano, Misa; Yu, Hong; Schlessinger, David; Ko, Minoru S H; Sharov, Alexei A

2016-10-01

Specific neuronal types derived from embryonic stem cells (ESCs) can facilitate mechanistic studies and potentially aid in regenerative medicine. Existing induction methods, however, mostly rely on the effects of the combined action of multiple added growth factors, which generally tend to result in mixed populations of neurons. Here, we report that overexpression of specific transcription factors (TFs) in ESCs can rather guide the differentiation of ESCs towards specific neuron lineages. Analysis of data on gene expression changes 2 d after induction of each of 185 TFs implicated candidate TFs for further ESC differentiation studies. Induction of 23 TFs (out of 49 TFs tested) for 6 d facilitated neural differentiation of ESCs as inferred from increased proportion of cells with neural progenitor marker PSA-NCAM. We identified early activation of the Notch signaling pathway as a common feature of most potent inducers of neural differentiation. The majority of neuron-like cells generated by induction of Ascl1, Smad7, Nr2f1, Dlx2, Dlx4, Nr2f2, Barhl2, and Lhx1 were GABA-positive and expressed other markers of GABAergic neurons. In the same way, we identified Lmx1a and Nr4a2 as inducers for neurons bearing dopaminergic markers and Isl1, Fezf2, and St18 for cholinergic motor neurons. A time-course experiment with induction of Ascl1 showed early upregulation of most neural-specific messenger RNA (mRNA) and microRNAs (miRNAs). Sets of Ascl1-induced mRNAs and miRNAs were enriched in Ascl1 targets. In further studies, enrichment of cells obtained with the induction of Ascl1, Smad7, and Nr2f1 using microbeads resulted in essentially pure population of neuron-like cells with expression profiles similar to neural tissues and expressed markers of GABAergic neurons. In summary, this study indicates that induction of transcription factors is a promising approach to generate cultures that show the transcription profiles characteristic of specific neural cell types.

Modular compact solid-state modulators for particle accelerators

Science.gov (United States)

Zavadtsev, A. A.; Zavadtsev, D. A.; Churanov, D. V.

2017-12-01

The building of the radio frequency (RF) particle accelerator needs high-voltage pulsed modulator as a power supply for klystron or magnetron to feed the RF accelerating system. The development of a number of solid-state modulators for use in linear accelerators has allowed to develop a series of modular IGBT based compact solid-state modulators with different parameters. This series covers a wide range of needs in accelerator technology to feed a wide range of loads from the low power magnetrons to powerful klystrons. Each modulator of the series is built on base of a number of unified solid-state modules connected to the pulse transformer, and covers a wide range of modulators: voltage up to 250 kV, a peak current up to 250 A, average power up to 100 kW and the pulse duration up to 20 μsec. The parameters of the block with an overall dimensions 880×540×250 mm are: voltage 12 kV, peak current 1600 A, pulse duration 20 μsec, average power 10 kW with air-cooling and 40 kW with liquidcooling. These parameters do not represent a physical limit, and modulators to parameters outside these ranges can be created on request.

Optimization Tool for Direct Water Cooling System of High Power IGBT Modules

DEFF Research Database (Denmark)

Bahman, Amir Sajjad; Blaabjerg, Frede

2016-01-01

important issue for thermal design engineers. This paper aims to present a user friendly optimization tool for direct water cooling system of a high power module which enables the cooling system designer to identify the optimized solution depending on customer load profiles and available pump power. CFD...

SiC JFET Cascode Loss Dependency on the MOSFET Output Capacitance and Performance Comparison with Trench IGBTs

DEFF Research Database (Denmark)

Pittini, Riccardo; Zhang, Zhe; Andersen, Michael A. E.

2013-01-01

output capacitance on the switching performance of the SiC Cascode connection in terms of switching energy loss, dV/dt and dI/dt stresses. The Cascode connection switching performances are compared with the switching performance latest Trench IGBTs. The analysis is based on a set of several laboratory...... measurements and data post-processing in order to properly characterize the devices and quantify whether the SiC JFET Cascode connection can provide good performances with a simple MOSFET gate driver....

Experimental study of single event burnout and single event gate rupture in power MOSFETs and IGBT

International Nuclear Information System (INIS)

Tang Benqi; Wang Yanping; Geng Bin

2001-01-01

An experimental study was carried out to determine the single event burnout and single event gate rupture sensitivities in power MOSFETs and IGBT which were exposed to heavy ions from 252 Cf source. The test method, test results, a description of observed burnout current waveforms and a discussion of a possible failure mechanism were presented. Current measurements have been performed with a specially designed circuit. The test results include the observed dependence upon applied drain or gate to source bias and versus with external capacitors and limited resistors

Analysis and Mitigation of Dead Time Harmonics in the Single-Phase Full-Bridge PWM Converters with Repetitive Controllers

DEFF Research Database (Denmark)

Yang, Yongheng; Zhou, Keliang; Wang, Huai

2018-01-01

In order to prevent the power switching devices (e.g., the Insulated-Gate-Bipolar-Transistor, IGBT) from shoot-through in voltage source converters during a switching period, the dead time is added either in the hardware driver circuits of the IGBTs or implemented in software in Pulse-Width Modul......In order to prevent the power switching devices (e.g., the Insulated-Gate-Bipolar-Transistor, IGBT) from shoot-through in voltage source converters during a switching period, the dead time is added either in the hardware driver circuits of the IGBTs or implemented in software in Pulse...

lambda. -prophage induction in repair-deficient and wild type E. coli strains by. gamma. -rays and heavy ions

Energy Technology Data Exchange (ETDEWEB)

Bonev, M.N.; Kozubek, S.; Krasavin, E.A.; Amirtajev, K.G. (Joint Inst. for Nuclear Research, Dubna (USSR))

1990-05-01

{lambda}-prophage induction in repair-deficient and wild-type E. coli strains by heavy ions and {gamma}-rays was investigated. The dose dependence of the fraction of induced cells has been measured and its initial slope ({lambda}-induction potency) determined. Induction by {gamma}-rays was found to be more efficient in a polA-repair-deficient strain; the value of {lambda}-induction potency is zero in lexA{sup -} and recA{sup -} strains. The {lambda}-induction potency potency increased with LET for wild-type cells but remained constant in polA{sup -} mutant cells. It is suggested that DNA damage triggering the {lambda}-prophage induction in the case of ionizing radiation could be a type of DNA single-strand break with complex structures which cannot be repaired by fast repair processes, and requires a substantial level of energy deposition for induction in a DNA molecule. (author).

Trial type probability modulates the cost of antisaccades

Science.gov (United States)

Chiau, Hui-Yan; Tseng, Philip; Su, Jia-Han; Tzeng, Ovid J. L.; Hung, Daisy L.; Muggleton, Neil G.

2011-01-01

The antisaccade task, where eye movements are made away from a target, has been used to investigate the flexibility of cognitive control of behavior. Antisaccades usually have longer saccade latencies than prosaccades, the so-called antisaccade cost. Recent studies have shown that this antisaccade cost can be modulated by event probability. This may mean that the antisaccade cost can be reduced, or even reversed, if the probability of surrounding events favors the execution of antisaccades. The probabilities of prosaccades and antisaccades were systematically manipulated by changing the proportion of a certain type of trial in an interleaved pro/antisaccades task. We aimed to disentangle the intertwined relationship between trial type probabilities and the antisaccade cost with the ultimate goal of elucidating how probabilities of trial types modulate human flexible behaviors, as well as the characteristics of such modulation effects. To this end, we examined whether implicit trial type probability can influence saccade latencies and also manipulated the difficulty of cue discriminability to see how effects of trial type probability would change when the demand on visual perceptual analysis was high or low. A mixed-effects model was applied to the analysis to dissect the factors contributing to the modulation effects of trial type probabilities. Our results suggest that the trial type probability is one robust determinant of antisaccade cost. These findings highlight the importance of implicit probability in the flexibility of cognitive control of behavior. PMID:21543748

A rugged 650 V SOI-based high-voltage half-bridge IGBT gate driver IC for motor drive applications

Science.gov (United States)

Hua, Qing; Li, Zehong; Zhang, Bo; Chen, Weizhong; Huang, Xiangjun; Feng, Yuxiang

2015-05-01

This paper proposes a rugged high-voltage N-channel insulated gate bipolar transistor (IGBT) gate driver integrated circuit. The device integrates a high-side and a low-side output stages on a single chip, which is designed specifically for motor drive applications. High-voltage level shift technology enables the high-side stage of this device to operate up to 650 V. The logic inputs are complementary metal oxide semiconductor (CMOS)/transistor transistor logic compatible down to 3.3 V. Undervoltage protection functionality with hysteresis characteristic has also been integrated to enhance the device reliability. The device is fabricated in a 1.0 μm, 650 V high-voltage bipolar CMOS double-diffused metal oxide semiconductor (BCD) on silicon-on-insulator (SOI) process. Deep trench dielectric isolation technology is employed to provide complete electrical isolation with advantages such as reduced parasitic effects, excellent noise immunity and low leakage current. Experimental results show that the isolation voltage of this device can be up to approximately 779 V at 25°C, and the leakage current is only 5 nA at 650 V, which is 15% higher and 67% lower than the conventional ones. In addition, it delivers an excellent thermal stability and needs very low quiescent current and offers a high gate driver capability which is needed to adequately drive IGBTs that have large input capacitances.

Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM.

Science.gov (United States)

McPhee, Joseph B; Mena, Patricio; Zhang, Yue; Bliska, James B

2012-07-01

Pathogenic Yersinia species modulate host immune responses through the activity of a plasmid-encoded type III secretion system and its associated effector proteins. One effector, YopM, is a leucine-rich-repeat-containing protein that is important for virulence in murine models of Yersinia infection. Although the mechanism by which YopM promotes virulence is unknown, we previously demonstrated that YopM was required for the induction of high levels of the immunosuppressive cytokine interleukin-10 (IL-10) in sera of C57BL/6J mice infected with Yersinia pseudotuberculosis. To determine if IL-10 production is important for the virulence function of YopM, C57BL/6J or congenic IL-10⁻/⁻ mice were infected intravenously with wild-type or yopM mutant Y. pseudotuberculosis strains. Analysis of cytokine levels in serum and bacterial colonization in the spleen and liver showed that YopM is required for IL-10 induction in C57BL/6J mice infected with either the IP32953 or the 32777 strain of Y. pseudotuberculosis, demonstrating that the phenotype is conserved in the species. In single-strain infections, the ability of the 32777ΔyopM mutant to colonize the liver was significantly increased by the delivery of exogenous IL-10 to C57BL/6J mice. In mixed infections, the competitive advantage of a yopM⁺ 32777 strain over an isogenic yopM mutant to colonize spleen and liver, as observed for C57BL/6J mice, was significantly reduced in IL-10⁻/⁻ animals. Thus, by experimentally controlling IL-10 levels in a mouse infection model, we obtained evidence that the induction of this cytokine is an important mechanism by which YopM contributes to Y. pseudotuberculosis virulence.

Neural network based PWM AC chopper fed induction motor drive

Directory of Open Access Journals (Sweden)

Venkatesan Jamuna

2009-01-01

Full Text Available In this paper, a new Simulink model for a neural network controlled PWM AC chopper fed single phase induction motor is proposed. Closed loop speed control is achieved using a neural network controller. To maintain a constant fluid flow with a variation in pressure head, drives like fan and pump are operated with closed loop speed control. The need to improve the quality and reliability of the drive circuit has increased because of the growing demand for improving the performance of motor drives. With the increased availability of MOSFET's and IGBT's, PWM converters can be used efficiently in low and medium power applications. From the simulation studies, it is seen that the PWM AC chopper has a better harmonic spectrum and lesser copper loss than the Phase controlled AC chopper. It is observed that the drive system with the proposed model produces better dynamic performance, reduced overshoot and fast transient response. .

Inductive Reasoning in Patients with Paranoid Type Schizophrenia

OpenAIRE

Mehmet Emrah Karadere; Yasir Safak; Halime Seyma Ozcelik; Emre Demir; Mehmet Hakan Turkcapar

2017-01-01

The goal of our study is to evaluate the decision making and reasoning of the paranoid type schizophrenic patients, and their confidence in reasoning and perseverance in keeping to their decisions via using Reasoning with Inductive Argument Test (RIAT). Thirty-two delusional patients and 30 healthy volunteers were included in the study. After the diagnostic interview was conducted by SCID-I to the patients who were asked to participate in the study, RIAT test was applied by the interviewe...

Improving Power Converter Reliability

DEFF Research Database (Denmark)

Ghimire, Pramod; de Vega, Angel Ruiz; Beczkowski, Szymon

2014-01-01

of a high-power IGBT module during converter operation, which may play a vital role in improving the reliability of the power converters. The measured voltage is used to estimate the module average junction temperature of the high and low-voltage side of a half-bridge IGBT separately in every fundamental......The real-time junction temperature monitoring of a high-power insulated-gate bipolar transistor (IGBT) module is important to increase the overall reliability of power converters for industrial applications. This article proposes a new method to measure the on-state collector?emitter voltage...... is measured in a wind power converter at a low fundamental frequency. To illustrate more, the test method as well as the performance of the measurement circuit are also presented. This measurement is also useful to indicate failure mechanisms such as bond wire lift-off and solder layer degradation...

Induction of chromosome aberrations in two lines of cultured cells using different types of radiation

International Nuclear Information System (INIS)

Zoetelief, J.; Dingjan-Hirschi, E.S.; Hasper, J.; Janse, H.C.; Barendsen, G.W.

The induction of chromosome aberrations has been investigated in two lines of cultured cells for different types of radiation. The obtained results are compared with information on induction of cell reproductive death and malignant transformation. (Auth.)

The Impact of Power Switching Devices on the Thermal Performance of a 10 MW Wind Power NPC Converter

DEFF Research Database (Denmark)

Ma, Ke; Blaabjerg, Frede

2012-01-01

Power semiconductor switching devices play an important role in the performance of high power wind energy generation systems. The state-of-the-art device choices in the wind power application as reported in the industry include IGBT modules, IGBT press-pack and IGCT press-pack. Because...

Reliability Assessment of Solder Joints in Power Electronic Modules by Crack Damage Model for Wind Turbine Applications

Directory of Open Access Journals (Sweden)

John D. Sørensen

2011-12-01

Full Text Available Wind turbine reliability is an important issue for wind energy cost minimization, especially by reduction of operation and maintenance costs for critical components and by increasing wind turbine availability. To develop an optimal operation and maintenance plan for critical components, it is necessary to understand the physics of their failure and be able to develop reliability prediction models. Such a model is proposed in this paper for an IGBT power electronic module. IGBTs are critical components in wind turbine converter systems. These are multilayered devices where layers are soldered to each other and they operate at a thermal-power cycling environment. Temperature loadings affect the reliability of soldered joints by developing cracks and fatigue processes that eventually result in failure. Based on Miner’s rule a linear damage model that incorporates a crack development and propagation processes is discussed. A statistical analysis is performed for appropriate model parameter selection. Based on the proposed model, a layout for component life prediction with crack movement is described in details.

Inductive Reasoning About Effectful Data Types

DEFF Research Database (Denmark)

Filinski, Andrzej; Støvring, Kristian

2007-01-01

We present a pair of reasoning principles, definition and proof by rigid induction, which can be seen as proper generalizations of lazy-datatype induction to monadic effects other than partiality. We further show how these principles can be integrated into logical-relations arguments, and obtain...

Modulating effects of thyroid state on the induction of biotransformation enzymes byu 2,3,7,8-tetrachlorodibenzo-p-dioxin.

NARCIS (Netherlands)

Schuur, A.G.; Tacken, P.J.; Visser, T.J.; Brouwer, A.

1998-01-01

In this study we investigated to what extent the induction of detoxification enzymes by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is modulated by concomitant TCDD-induced changes in thyroid state. Euthyroid (Eu) male Sprague-Dawley rats, surgically thyroidectomized (Tx) rats and Tx rats receiving

DMPD: Type I interferon [corrected] gene induction by the interferon regulatory factorfamily of transcription factors. [Dynamic Macrophage Pathway CSML Database

Lifescience Database Archive (English)

Full Text Available 16979567 Type I interferon [corrected] gene induction by the interferon regulatory factorfamily...ng) (.svg) (.html) (.csml) Show Type I interferon [corrected] gene induction by the interferon regulatory factorfamily...orrected] gene induction by the interferon regulatory factorfamily of transcription factors. Authors Honda K

Fixation of operating point and measurement of turn on characteristics of IGBT F4-75R06W1E3

Science.gov (United States)

Haseena, A.; Subhash Joshi T., G.; George, Saly

2018-05-01

For the proficient operation of the Power electronic circuit, signal level performance of power electronic devices are very important. For getting good signal level characteristics, fixing operating point is very critical. Device deviates from the typical characteristics given in the datasheet due to the presence of stray components in the circuit lay out. Fixation of operating point of typical silicon IGBT and its turn on characteristics is discussed in this paper.

Slot Optimization Design of Induction Motor for Electric Vehicle

Science.gov (United States)

Shen, Yiming; Zhu, Changqing; Wang, Xiuhe

2018-01-01

Slot design of induction motor has a great influence on its performance. The RMxprt module based on magnetic circuit method can be used to analyze the influence of rotor slot type on motor characteristics and optimize slot parameters. In this paper, the authors take an induction motor of electric vehicle for a typical example. The first step of the design is to optimize the rotor slot by RMxprt, and then compare the main performance of the motor before and after the optimization through Ansoft Maxwell 2D. After that, the combination of optimum slot type and the optimum parameters are obtained. The results show that the power factor and the starting torque of the optimized motor have been improved significantly. Furthermore, the electric vehicle works at a better running status after the optimization.

Differential growth factor induction and modulation of human gastric epithelial regeneration

International Nuclear Information System (INIS)

Tetreault, Marie-Pier; Chailler, Pierre; Rivard, Nathalie; Menard, Daniel

2005-01-01

While several autocrine/paracrine growth factors (GFs) can all stimulate epithelial regeneration in experimentally wounded primary gastric cultures, clinical relevance for their non-redundant cooperative actions in human gastric ulcer healing is suggested by the sequential pattern of GF gene induction in vivo. Using new HGE cell lines able to form a coherent monolayer with tight junctions as well as using primary human gastric epithelial cultures, we show that EGF, TGFα, HGF and IGFs accelerate epithelial restitution upon wounding, independently of the TGFβ pathway (as opposed to intestinal cells). However, they differently modulate cell behavior: TGFα exerts strong effects (even more than EGF) on cytoplasmic spreading and non-oriented protruding activity of bordering cells whereas HGF preferentially coordinates single lamella formation, cell elongation and migration into the wound. IGF-I and IGF-II rather induce the alignment of bordering cells and maintain a compact monolayer front. The number of mitotic cells maximally increases with EGF, followed by TGFα and IGF-I,-II. The current study demonstrates that GFs differentially regulate the regeneration of human gastric epithelial cells through specific modulation of cell shape adaptation, migration and proliferation, further stressing that a coordination of GF activities would be necessary for the normal progression of post-wounding epithelial repair

Module type plant system dynamics analysis code (MSG-COPD). Code manual

International Nuclear Information System (INIS)

Sakai, Takaaki

2002-11-01

MSG-COPD is a module type plant system dynamics analysis code which involves a multi-dimensional thermal-hydraulics calculation module to analyze pool type of fast breeder reactors. Explanations of each module and the methods for the input data are described in this code manual. (author)

Inductance analysis of superconducting quantum interference devices with 3D nano-bridge junctions

Science.gov (United States)

Wang, Hao; Yang, Ruoting; Li, Guanqun; Wu, Long; Liu, Xiaoyu; Chen, Lei; Ren, Jie; Wang, Zhen

2018-05-01

Superconducting quantum interference devices (SQUIDs) with 3D nano-bridge junctions can be miniaturized into nano-SQUIDs that are able to sense a few spins in a large magnetic field. Among all device parameters, the inductance is key to the performance of SQUIDs with 3D nano-bridge junctions. Here, we measured the critical-current magnetic flux modulation curves of 12 devices with three design types using a current strip-line directly coupled to the SQUID loop. A best flux modulation depth of 71% was achieved for our 3D Nb SQUID. From the modulation curves, we extracted the inductance values of the current stripe-line in each design and compared them with the corresponding simulation results of InductEX. In this way, London penetration depths of 110 and 420 nm were determined for our Nb (niobium) and NbN (niobium nitride) films, respectively. Furthermore, we showed that inductances of 11 and 119 pH for Nb and NbN 3D nano-bridge junctions, respectively, dominated the total inductance of our SQUID loops which are 23 pH for Nb and 255 pH for NbN. A screening parameter being equal to one suggests optimal critical currents of 89.6 and 8.1 μA for Nb and NbN SQUIDs, respectively. Additionally, intrinsic flux noise of 110 ± 40 nΦ0/(Hz)1/2 is calculated for the Nb SQUIDs with 3D nano-bridge junctions by Langevin simulation.

Analysis of a flux-coupling type superconductor fault current limiter with pancake coils

Science.gov (United States)

Liu, Shizhuo; Xia, Dong; Zhang, Zhifeng; Qiu, Qingquan; Zhang, Guomin

2017-10-01

The characteristics of a flux-coupling type superconductor fault current limiter (SFCL) with pancake coils are investigated in this paper. The conventional double-wound non-inductive pancake coil used in AC power systems has an inevitable defect in Voltage Sourced Converter Based High Voltage DC (VSC-HVDC) power systems. Due to its special structure, flashover would occur easily during the fault in high voltage environment. Considering the shortcomings of conventional resistive SFCLs with non-inductive coils, a novel flux-coupling type SFCL with pancake coils is carried out. The module connections of pancake coils are performed. The electromagnetic field and force analysis of the module are contrasted under different parameters. To ensure proper operation of the module, the impedance of the module under representative operating conditions is calculated. Finally, the feasibility of the flux-coupling type SFCL in VSC-HVDC power systems is discussed.

Electro-thermal Modeling of Modern Power Devices for Studying Abnormal Operating Conditions

DEFF Research Database (Denmark)

Wu, Rui

in industrial power electronic systems in the range above 10 kW. The failure of IGBTs can be generally classified as catastrophic failures and wear out failures. A wear out failure is mainly induced by accumulated degradation with time, while a catastrophic failure is triggered by a single-event abnormal....... The objective of this project has been to model and predict the electro-thermal behavior of IGBT power modules under abnormal conditions, especially short circuits. A thorough investigation on catastrophic failure modes and mechanisms of modern power semiconductor devices, including IGBTs and power diodes, has...

Novel screening techniques for wind turbine power converters

DEFF Research Database (Denmark)

Jørgensen, Asger Bjørn; Sønderskov, Simon Dyhr; Christensen, Nicklas

2016-01-01

Power converters represent one of the highest failure rates in the wind turbine. Therefore converter manufacturers perform burn-in tests to prevent shipping of faulty converters. Recent developments in junction temperature estimation, based on accurate online IGBT collector-emitter voltage...... measurements, allow for thermal stress estimation of the IGBT modules. This is utilized to detect infant mortalities in power converters, by comparing thermal responses of IGBTs for faulty and non-faulty converters. The method proves to be a time and cost efficient candidate to replace burn-in tests of power...... converters for wind turbines applications....

Berkeley research program on ion-induction linacs for inertial fusion

International Nuclear Information System (INIS)

Keefe, D.; Rosenblum, S.S.

1982-03-01

The following areas of research are described: (1) driver studies, (2) induction linac technology, (3) core materials, (4) insulators, (5) modulator-switches and pulse forming network, (6) induction linac accelerators and prototype modules, and (7) a high-temperature experiment

Linear induction accelerators made from pulse-line cavities with external pulse injection

International Nuclear Information System (INIS)

Smith, I.

1979-01-01

Two types of linear induction accelerator have been reported previously. In one, unidirectional voltage pulses are generated outside the accelerator and injected into the accelerator cavity modules, which contain ferromagnetic material to reduce energy losses in the form of currents induced, in parallel with the beam, in the cavity structure. In the other type, the accelerator cavity modules are themselves pulse-forming lines with energy storage and switches; parallel current losses are made zero by the use of circuits that generate bidirectional acceleration waveforms with a zero voltage-time integral. In a third type of design described here, the cavities are externally driven, and 100% efficient coupling of energy to the beam is obtained by designing the external pulse generators to produce bidirectional voltage waveforms with zero voltage-time integral. A design for such a pulse generator is described that is itself one hundred percent efficient and which is well suited to existing pulse power techniques. Two accelerator cavity designs are described that can couple the pulse from such a generator to the beam; one of these designs provides voltage doubling. Comparison is made between the accelerating gradients that can be obtained with this and the preceding types of induction accelerator

Fault-tolerant design approach for reliable offshore multi-megawatt variable frequency converters

Directory of Open Access Journals (Sweden)

N. Vedachalam

2016-09-01

Full Text Available Inverters play a key role in realizing reliable multi-megawatt power electronic converters used in offshore applications, as their failure leads to production losses and impairs safety. The performance of high power handing semiconductor devices with high speed control capabilities and redundant configurations helps in realizing a fault-tolerant design. This paper describes the reliability modeling done for an industry standard, 3-level neutral point clamped multi-megawatt inverter, the significance of semiconductor redundancy in reducing inverter failure rates, and proposes methods for achieving static and dynamic redundancy in series connected press pack type insulated gate bipolar transistors (IGBT. It is identified that, with the multi megawatt inverter having 3+2 IGBT in each half leg with dynamic redundancy incorporated, it is possible to reduce the failure rate of the inverter from 53.8% to 15% in 5 years of continuous operation. The simulation results indicate that with dynamic redundancy, it is possible to force an untriggered press pack IGBT to short circuit in <1s, when operated with a pulse width modulation frequency of 1kHz.

A novel nicotinic agonist facilitates induction of long-term potentiation in the rat hippocampus.

Science.gov (United States)

Hunter, B E; de Fiebre, C M; Papke, R L; Kem, W R; Meyer, E M

1994-02-28

Long-term potentiation (LTP) can be modulated by a number of neurotransmitter receptors including muscarinic and GABAergic receptor types. We have found that a novel nicotinic agonist, 2,4-dimethoxybenzylidene anabaseine (DMXB), facilitated the induction of LTP in the hippocampus in a dose-dependent and mecamylamine-sensitive manner. DMXB displaced high affinity nicotinic [125I]alpha-bungarotoxin and [3H]acetylcholine binding in rat brain. Xenopus oocyte studies demonstrated that DMXB has agonist activity at alpha 7 but not alpha 4/beta 2 nicotinic receptor subtypes. These results indicated that DMXB is a novel nicotinic agonist with apparent specificity for the alpha 7/alpha-bungarotoxin nicotinic receptor subtype and indicate that nicotinic receptor activation is capable of modulating the induction of long-term potentiation.

A battery-powered high-current power supply for superconductors

CERN Document Server

Wake, M; Suda, K

2002-01-01

Since superconductors do not require voltages, a high-current power supply could run with low power if the voltage is sufficiently reduced. Even a battery-powered power supply could give as much as 2,000A for a superconductor. To demonstrate this hypothesis, a battery-powered 2,000A power supply was constructed. It uses an IGBT chopper and Schottky diode together with a specially arranged transformer to produce a high current with low voltage. Testing of 2,000A operation was performed for about 1.5 hr using 10 car batteries. Charging time for this operation was 8 hr. Ramping control was smooth and caused no trouble. Although the IGBT frequency ripple of 16.6 kHz was easily removed using a passive filter, spike noise remained in the output voltage. This ripple did not cause any trouble in operating a pancake-type inductive superconducting load. (author)

Fast response double series resonant high-voltage DC-DC converter

International Nuclear Information System (INIS)

Lee, S S; Iqbal, S; Kamarol, M

2012-01-01

In this paper, a novel double series resonant high-voltage dc-dc converter with dual-mode pulse frequency modulation (PFM) control scheme is proposed. The proposed topology consists of two series resonant tanks and hence two resonant currents flow in each switching period. Moreover, it consists of two high-voltage transformer with the leakage inductances are absorbed as resonant inductor in the series resonant tanks. The secondary output of both transformers are rectified and mixed before supplying to load. In the resonant mode operation, the series resonant tanks are energized alternately by controlling two Insulated Gate Bipolar Transistor (IGBT) switches with pulse frequency modulation (PFM). This topology operates in discontinuous conduction mode (DCM) with all IGBT switches operating in zero current switching (ZCS) condition and hence no switching loss occurs. To achieve fast rise in output voltage, a dual-mode PFM control during start-up of the converter is proposed. In this operation, the inverter is started at a high switching frequency and as the output voltage reaches 90% of the target value, the switching frequency is reduced to a value which corresponds to the target output voltage. This can effectively reduce the rise time of the output voltage and prevent overshoot. Experimental results collected from a 100-W laboratory prototype are presented to verify the effectiveness of the proposed system.

Spine formation pattern of adult-born neurons is differentially modulated by the induction timing and location of hippocampal plasticity.

Directory of Open Access Journals (Sweden)

Noriaki Ohkawa

Full Text Available In the adult hippocampus dentate gyrus (DG, newly born neurons are functionally integrated into existing circuits and play important roles in hippocampus-dependent memory. However, it remains unclear how neural plasticity regulates the integration pattern of new neurons into preexisting circuits. Because dendritic spines are major postsynaptic sites for excitatory inputs, spines of new neurons were visualized by retrovirus-mediated labeling to evaluate integration. Long-term potentiation (LTP was induced at 12, 16, or 21 days postinfection (dpi, at which time new neurons have no, few, or many spines, respectively. The spine expression patterns were investigated at one or two weeks after LTP induction. Induction at 12 dpi increased later spinogenesis, although the new neurons at 12 dpi didn't respond to the stimulus for LTP induction. Induction at 21 dpi transiently mediated spine enlargement. Surprisingly, LTP induction at 16 dpi reduced the spine density of new neurons. All LTP-mediated changes specifically appeared within the LTP-induced layer. Therefore, neural plasticity differentially regulates the integration of new neurons into the activated circuit, dependent on their developmental stage. Consequently, new neurons at different developmental stages may play distinct roles in processing the acquired information by modulating the connectivity of activated circuits via their integration.

Author Details

African Journals Online (AJOL)

Abu-Rub, H. Vol 1, No 1 (2009) - Articles Comparative performance analysis of Thyristor and IGBT based induction motor soft starters. Abstract PDF · Vol 2, No 10 (2010) - Articles Sensorless induction motor drive for electric vehicle application. Abstract PDF. ISSN: 2141-2839. AJOL African Journals Online. HOW TO USE ...

Characteristics of The Magnet Wheel As A Magnetic Levitation Device of Induction Type

OpenAIRE

藤井, 信男; 小川, 幸吉; 松本, 敏雄; Nobuo, FUJII; Kokichi, OGAWA; Toshio, MATSUMOTO; 九州大学; 大分大学; 安川電機; Kyushu University; Oita University; Yaskawa Electric Co., Ltd.

1996-01-01

A new type of magnetic wheel called the "magnet wheel" has been proposed. The magnet wheel has both magnetic levitation and linear drive functions combined into one. In the magnet wheel, the permanent magnets are rotated over the conducting plate so that an induction type of repulsive lift force is obtained. To produce thrust from the drag torque which is simultaneously induced with the lift force, the "tilt type" and "partial overlap type" magnet wheels have been proposed. Poor power factor ...

Efficiency Investigations of a 3 kW T-Type Inverter for Switching Frequencies up to 100 kHz

DEFF Research Database (Denmark)

Anthon, Alexander; Zhang, Zhe; Andersen, Michael A. E.

2014-01-01

This paper deals with a 3kW multilevel inverter used for PV applications. A comparison has been made based on simulations using IGBTs and SiC MOSFETs to see how much efficiency can be gained when SiC diodes are used. A prototype with the same IGBTs and SiC MOSFETs has been built but using regular...... soft-recovery Si diodes instead of SiC diodes. Efficiencies and switching transitions for different switching frequencies up to 100 kHz have been measured. Thermal investigations of both IGBTs and SiC MOSFETs have been conducted to analyze the feasibility of increased switching frequencies. When Si......C MOSFETs are used in combination with Si diodes, switching frequencies could be doubled achieving the same efficiencies than the IGBT converter....

Programmable type III-A CRISPR-Cas DNA targeting modules.

Directory of Open Access Journals (Sweden)

H Travis Ichikawa

Full Text Available The CRISPR-Cas systems provide invader defense in a wide variety of prokaryotes, as well as technologies for many powerful applications. The Type III-A or Csm CRISPR-Cas system is one of the most widely distributed across prokaryotic phyla, and cleaves targeted DNA and RNA molecules. In this work, we have constructed modules of Csm systems from 3 bacterial species and heterologously expressed the functional modules in E. coli. The modules include a Cas6 protein and a CRISPR locus for crRNA production, and Csm effector complex proteins. The expressed modules from L. lactis, S. epidermidis and S. thermophilus specifically eliminate invading plasmids recognized by the crRNAs of the systems. Characteristically, activation of plasmid targeting activity depends on transcription of the plasmid sequence recognized by the crRNA. Activity was not observed when transcription of the crRNA target sequence was blocked, or when the opposite strand or a non-target sequence was transcribed. Moreover, the Csm module can be programmed to recognize plasmids with novel target sequences by addition of appropriate crRNA coding sequences to the module. These systems provide a platform for investigation of Type III-A CRISPR-Cas systems in E. coli, and for introduction of programmable transcription-activated DNA targeting into novel organisms.

Induction of non-responsiveness in human allergen-specific type 2 T helper cells.

Science.gov (United States)

Yssel, H; Fasler, S; Lamb, J; de Vries, J E

1994-12-01

Activation of allergen-reactive human T helper (Th)2 cells in the absence of professional antigen-presenting cells, induces non-responsiveness or anergy in these cells in vitro. This induction of anergy is accompanied by phenotypic modulation and altered cytokine production. Furthermore, peptide-treated Th2 cells fail to provide B-cell help for IgE synthesis. Recent studies indicate that impaired signal transduction via the T-cell receptor may account for the lack of responsiveness to antigenic stimulation. Here, we review present knowledge on the cell biology of non-responsive or anergic Th2 cells.

12-lipoxygenase regulates hippocampal long-term potentiation by modulating L-type Ca2+ channels

Science.gov (United States)

DeCostanzo, Anthony J.; Voloshyna, Iryna; Rosen, Zev B.; Feinmark, Steven J.; Siegelbaum, Steven A.

2010-01-01

Although long-term potentiation (LTP) has been intensely studied, there is disagreement as to which molecules mediate and modulate LTP. This is partly due to the presence of mechanistically distinct forms of LTP that are induced by different patterns of stimulation and that depend on distinct Ca2+ sources. Here we report a novel role for the arachidonic acid-metabolizing enzyme 12-lipoxygenase (12-LO) in LTP at CA3-CA1 hippocampal synapses that is dependent on the pattern of tetanic stimulation. We find that 12-LO activity is required for the induction of LTP in response to a theta-burst stimulation (TBS) protocol, which depends on Ca2+ influx through both NMDA receptors and L-type voltage-gated Ca2+ channels. In contrast, LTP induced by 100 Hz tetanic stimulation, which requires Ca2+ influx through NMDA receptors but not L-type channels, does not require 12-LO. We find that 12-LO regulates LTP by enhancing postsynaptic somatodendritic Ca2+ influx through L-type channels during theta burst stimulation, an action exerted via 12(S)-HPETE, a downstream metabolite of 12-LO. These results help define the role of a long-disputed signaling enzyme in LTP. PMID:20130191

Interferon Induction by RNA Viruses and Antagonism by Viral Pathogens

Directory of Open Access Journals (Sweden)

Yuchen Nan

2014-12-01

Full Text Available Interferons are a group of small proteins that play key roles in host antiviral innate immunity. Their induction mainly relies on host pattern recognition receptors (PRR. Host PRR for RNA viruses include Toll-like receptors (TLR and retinoic acid-inducible gene I (RIG-I like receptors (RLR. Activation of both TLR and RLR pathways can eventually lead to the secretion of type I IFNs, which can modulate both innate and adaptive immune responses against viral pathogens. Because of the important roles of interferons, viruses have evolved multiple strategies to evade host TLR and RLR mediated signaling. This review focuses on the mechanisms of interferon induction and antagonism of the antiviral strategy by RNA viruses.

Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-β expression

Energy Technology Data Exchange (ETDEWEB)

Siddiqui, Shabeena [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Ahsan, Haseeb [Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025 (India); Khan, Mohammad Rashid [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Siddiqui, Waseem A., E-mail: wasiddiqui01@gmail.com [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India)

2013-12-01

Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). Hyperlipidemia and hyperglycemia act synergistically to induce renal injury. The present study was designed to investigate the protective effects of tocotrienols as tocotrienol-rich fraction (TRF) extracted from palm (PO) and rice bran oils (RBO) against lipid induced nephropathy in type-2 diabetic rats and its probable molecular mechanism. Male Wistar rats (175–200 g) were divided into four groups. The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. The fourth group comprised of age-matched rats that served as normal control. The effects of TRF on serum lipid profile, oxidative stress markers, expression of TGF-β, fibronectin and collagen type IV were analyzed in the kidney of diabetic rats. Treatment with PO-TRF and RBO-TRF significantly improved glycemic status, serum lipid profile and renal function in type-2 diabetic rats. In addition, TRF supplementation down-regulated the expression of TGF-β, fibronectin and collagen type IV in the kidney of diabetic rats. Transforming growth factor-β (TGF-β) plays a critical role in progression of DN, but its modulation by tocotrienols in DN remains unexplored. TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-β to prevent increased expression of collagen type IV and fibrinogen. We finally propose a mechanism for the expression of molecular markers that are significant in the events leading to diabetic nephropathy and its modulation by tocotrienols/TRF. - Highlights: • The nephroprotective effect of TRF in type-2 diabetic rats was investigated. • Treatment with TRF improved glycemic status, lipid profile and renal functions in rats

Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-β expression

International Nuclear Information System (INIS)

Siddiqui, Shabeena; Ahsan, Haseeb; Khan, Mohammad Rashid; Siddiqui, Waseem A.

2013-01-01

Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). Hyperlipidemia and hyperglycemia act synergistically to induce renal injury. The present study was designed to investigate the protective effects of tocotrienols as tocotrienol-rich fraction (TRF) extracted from palm (PO) and rice bran oils (RBO) against lipid induced nephropathy in type-2 diabetic rats and its probable molecular mechanism. Male Wistar rats (175–200 g) were divided into four groups. The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. The fourth group comprised of age-matched rats that served as normal control. The effects of TRF on serum lipid profile, oxidative stress markers, expression of TGF-β, fibronectin and collagen type IV were analyzed in the kidney of diabetic rats. Treatment with PO-TRF and RBO-TRF significantly improved glycemic status, serum lipid profile and renal function in type-2 diabetic rats. In addition, TRF supplementation down-regulated the expression of TGF-β, fibronectin and collagen type IV in the kidney of diabetic rats. Transforming growth factor-β (TGF-β) plays a critical role in progression of DN, but its modulation by tocotrienols in DN remains unexplored. TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-β to prevent increased expression of collagen type IV and fibrinogen. We finally propose a mechanism for the expression of molecular markers that are significant in the events leading to diabetic nephropathy and its modulation by tocotrienols/TRF. - Highlights: • The nephroprotective effect of TRF in type-2 diabetic rats was investigated. • Treatment with TRF improved glycemic status, lipid profile and renal functions in rats

Protective effects of tocotrienols against lipid-induced nephropathy in experimental type-2 diabetic rats by modulation in TGF-β expression

Energy Technology Data Exchange (ETDEWEB)

Siddiqui, Shabeena [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Ahsan, Haseeb [Department of Biochemistry, Faculty of Dentistry, Jamia Millia Islamia, New Delhi 110025 (India); Khan, Mohammad Rashid [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India); Siddiqui, Waseem A., E-mail: wasiddiqui01@gmail.com [Department of Biochemistry, Lipid Metabolism Laboratory, Jamia Hamdard (Hamdard University), New Delhi 110062 (India)

2013-12-01

Dyslipidemia is common in patients with diabetes mellitus (DM) and is considered a risk factor for the progression of diabetic nephropathy (DN). Hyperlipidemia and hyperglycemia act synergistically to induce renal injury. The present study was designed to investigate the protective effects of tocotrienols as tocotrienol-rich fraction (TRF) extracted from palm (PO) and rice bran oils (RBO) against lipid induced nephropathy in type-2 diabetic rats and its probable molecular mechanism. Male Wistar rats (175–200 g) were divided into four groups. The first group served as diabetic control, while the second and third groups received PO-TRF and RBO-TRF, respectively by gavage over a period of sixteen weeks post-induction of diabetes. The fourth group comprised of age-matched rats that served as normal control. The effects of TRF on serum lipid profile, oxidative stress markers, expression of TGF-β, fibronectin and collagen type IV were analyzed in the kidney of diabetic rats. Treatment with PO-TRF and RBO-TRF significantly improved glycemic status, serum lipid profile and renal function in type-2 diabetic rats. In addition, TRF supplementation down-regulated the expression of TGF-β, fibronectin and collagen type IV in the kidney of diabetic rats. Transforming growth factor-β (TGF-β) plays a critical role in progression of DN, but its modulation by tocotrienols in DN remains unexplored. TRF ameliorated lipid induced nephropathy in type-2 diabetes by its hypoglycemic, hypolipidemic and antioxidant activities as well as by modulation of TGF-β to prevent increased expression of collagen type IV and fibrinogen. We finally propose a mechanism for the expression of molecular markers that are significant in the events leading to diabetic nephropathy and its modulation by tocotrienols/TRF. - Highlights: • The nephroprotective effect of TRF in type-2 diabetic rats was investigated. • Treatment with TRF improved glycemic status, lipid profile and renal functions in rats

Structure of a fibronectin type III-like module from Clostridium thermocellum

International Nuclear Information System (INIS)

Alahuhta, Markus; Xu, Qi; Brunecky, Roman; Adney, William S.; Ding, Shi-You; Himmel, Michael E.; Lunin, Vladimir V.

2010-01-01

The 1.6 Å resolution structure of a fibronectin type III-like module from Clostridium thermocellum with two molecules in the asymmetric unit is reported. The 1.6 Å resolution structure of a fibronectin type III-like module from Clostridium thermocellum with two molecules in the asymmetric unit is reported. The crystals used for data collection belonged to space group P2 1 2 1 2 1 , with unit-cell parameters a = 35.43, b = 45.73, c = 107.72 Å, and the structure was refined to an R factor of 0.166. Structural comparisons found over 800 similar structures in the Protein Data Bank. The broad range of different proteins or protein domains with high structural similarity makes it especially demanding to classify these proteins. Previous studies of fibronectin type III-like modules have indicated that they might function as ligand-binding modules, as a compact form of peptide linkers or spacers between other domains, as cellulose-disrupting modules or as proteins that help large enzyme complexes remain soluble

A novel steady state wind turbine simulator using an inverter controlled induction motor

Energy Technology Data Exchange (ETDEWEB)

Kojabadi, H.M.; Liuchen Chang

2005-07-01

This paper presents a new wind turbine simulator for steady state conditions. In order to provide a test platform for wind turbine drive trains, the authors have developed an experimental system to simulate the static characteristics of real wind turbines. This system consists of a 10 hp induction motor (IM), which drives a synchronous generator and is driven by a 10 kW variable-speed drive inverter, and real time control software. A microcontroller, a PC interfaced to a LAB Windows I/O board, and an IGBT inverter-controlled induction motor are used instead of a real wind turbine to supply shaft torque. A control program written in the C language is developed that obtains wind profiles and, by using turbine characteristics and the rotational speed of the IM, calculates the theoretical shaft torque of a real wind turbine. Based on the comparison of the measured torque with this demand torque, the shaft torque of the IM is regulated accordingly by controlling stator current demand and frequency demand of an inverter. In this way, the relationships between shaft rotating speed, shaft torque of the IM and wind speed are made to conform to the characteristics of a real wind turbine. The drive is controlled using the measured shaft torque directly, instead of estimating it as conventional drives do. (author)

Numerical modeling and design of a disk-type rotating permanent magnet induction pump

Energy Technology Data Exchange (ETDEWEB)

Koroteeva, E., E-mail: koroteeva@physics.msu.ru [Institute of Physics of University of Latvia, Salaspils 2169 (Latvia); Lomonosov Moscow State University, Moscow 119991 (Russian Federation); Ščepanskis, M. [Laboratory for Mathematical Modelling of Environmental and Technological Processes, University of Latvia, Rīga 1002 (Latvia); Bucenieks, I.; Platacis, E. [Institute of Physics of University of Latvia, Salaspils 2169 (Latvia)

2016-05-15

Highlights: • The design and performance of a disk-type induction pump are described. • A 3D numerical model based on an iterative coupling between EM and hydrodynamic solvers is developed. • The model is verified by comparing with the experiments in a Pb-Bi loop facility. • The suggestions are given to estimate the pump performance in a Pb-Li loop at high pressures. - Abstract: Electromagnetic induction pumps with rotating permanent magnets appear to be the most promising devices to transport liquid metals in high-temperature applications. Here we present a numerical methodology to simulate the operation of one particular modification of these types of pumps: a disk-type induction pump. The numerical model allows for the calculation and analysis of the flow parameters, including the pressure–flow rate characteristics of the pump. The simulations are based on an iterative fully coupled scheme for electromagnetic and hydrodynamic solvers. The developed model is verified by comparing with experimental data obtained using a Pb-Bi loop test facility, for pressures up to 4 bar and flow rates up to 9 kg/s. The verified model is then expanded to higher pressures, beyond the limits of the experimental loop. Based on the numerical simulations, suggestions are given to extrapolate experimental data to higher (industrially important) pressure ranges. Using the numerical model and analytical estimation, the pump performance for the Pb-Li loop is also examined, and the ability of the designed pump to develop pressure heads over 6 bar and to provide flow rates over 15 kg/s is shown.

Converter-Modulator Design and Operations for the ILC L-band Test Stand

Energy Technology Data Exchange (ETDEWEB)

Reass, William A.; /Los Alamos; Burkhart, C.; Adolphsen, Chris E.; Beukers, T.; Cassel, R.; de Lira, A.; Papas, C.; Nguyen, M.; Went, R.; /SLAC; Anderson, David E.; /Oak

2007-09-10

To facilitate a rapid response to the International Linear Collider (ILC) L-band development program at SLAC, a spare converter-modulator was shipped from LANL. This modulator was to be a spare for the spallation neutron source (SNS) accelerator at ORNL. The ILC application requires a 33% higher peak output power (15 MW) and output current (120 Amp). This presents significant design challenges to modify the existing hardware and yet maintain switching parameters and thermal cycling within the semiconductor component ratings. To minimize IGBT commutation and free-wheeling diode currents, a different set of optimizations, as compared to the SNS design, were used to tune the resonant switching networks. Additional complexities arose as nanocrystalline cores with different performance characteristics (as compared to SNS), were used to fabricate the resonant 'boost' transformers. This paper will describe the electrical design, modeling efforts, and resulting electrical performance as implemented for the ILC L-band test stand.

Reproducible and controllable induction voltage adder for scaled beam experiments

Energy Technology Data Exchange (ETDEWEB)

Sakai, Yasuo; Nakajima, Mitsuo; Horioka, Kazuhiko [Department of Energy Sciences, Tokyo Institute of Technology, 4259 Nagatsuta, Midori-ku, Yokohama 226-8502 (Japan)

2016-08-15

A reproducible and controllable induction adder was developed using solid-state switching devices and Finemet cores for scaled beam compression experiments. A gate controlled MOSFET circuit was developed for the controllable voltage driver. The MOSFET circuit drove the induction adder at low magnetization levels of the cores which enabled us to form reproducible modulation voltages with jitter less than 0.3 ns. Preliminary beam compression experiments indicated that the induction adder can improve the reproducibility of modulation voltages and advance the beam physics experiments.

Inductive energy store (IES) technology for multi-terrawatt generators

International Nuclear Information System (INIS)

Sincerny, P.S.; Ashby, S.R.; Childers, F.K.; Deeney, C.; Kortbawi, D.; Goyer, J.R.; Riordan, J.C.; Roth, I.S.; Stallings, C.; Schlitt, L.

1993-01-01

An IES pulsed power machine has been built at Physics International Company that serves as a prototype demonstration of IES technology that is scaleable to very large TW generators. The prototype module utilizes inductive store opening switch technology for the final stage of pulse compression and is capable of driving both electron beam Bremsstrahlung loads or imploding plasma loads. Each module consists of a fast discharge Marx driving a water dielectric transfer capacitor which is command triggered to drive the inductive store section of the machine. The inductive store is discharged into the load using a plasma erosion opening switch. Data demonstrating 22% efficient operation into an electron beam diode load are presented. The system issues addressing the combining of these modules into a very large pulsed power machine are discussed

Callus induction and plant regeneration from different explant types of Miscanthus x ogiformis Honda 'Giganteus'

DEFF Research Database (Denmark)

Holme, Inger Bæksted; Petersen, Karen Koefoed

1996-01-01

. The explants were cultured on urashige and Skoog medium supplemented with 4.5, 13.6, 22.6 or 31.7 μM 2,4-dichlorophenoxyacetic acid. Three types of callus were formed but only one was embryogenic and regenerated plants. Callus induction and formation of embryogenic callus depended on the type and developmental......-propagated shoots and older leaves of greenhouse-grown plants. Immature inflorescences smaller than 2.5 cm produced a higher percentage of embryogenic callus than larger more mature inflorescences. Embryogenic callus derived from immature inflorescences had the highest regeneration capacity. Differences in 2......,4-dichlorophenoxyacetic acid concentrations had no significant effect on callus induction, embryogenic callus formation and plant regeneration....

H-Bridge Transformerless Inverter with Common Ground for Single-Phase Solar-Photovoltaic System

DEFF Research Database (Denmark)

Siwakoti, Yam Prasad; Blaabjerg, Frede

2017-01-01

This paper proposes a new single-phase H-Bridge transformerless inverter with common ground for grid-connected photovoltaic systems (hereafter it is called ‘Siwakoti-H’ inverter). The inverter works on the principle of flying capacitor and consists of only four power switches (two reverse blocking...... IGBT's (RB-IGBT) and two MOSFET's), a capacitor and a small filter at the output stage. The proposed topology share a common ground with the grid and the PV source. A Unipolar Sinusoidal Pulse-Width Modulation (SPWM) technique is used to modulate the inverter to minimize switching loss, output current...

Power flow control strategy in distribution network for dc type distributed energy resource at load bus

International Nuclear Information System (INIS)

Hanif, A.; Choudhry, M.A.

2013-01-01

This research work presents a feed forward power flow control strategy in the secondary distribution network working in parallel with a DC type distributed energy resource (DER) unit with SPWM-IGBT Voltage Source Converter (VSC). The developed control strategy enables the VSC to be used as power flow controller at the load bus in the presence of utility supply. Due to the investigated control strategy, power flow control from distributed energy resource (DER) to common load bus is such that power flows to the load without facing any power quality problem. The technique has an added advantage of controlling power flow without having a dedicated power flow controller. The SPWM-IGBT VSC is serving the purpose of dc-ac converter as well as power flow controller. Simulations for a test system using proposed power flow control strategy are carried out using SimPower Systems toolbox of MATLAB at the rate and Simulink at the rate. The results show that a reliable, effective and efficient operation of DC type DER unit in coordination with main utility network can be achieved. (author)

A Float Type Liquid Level Measuring System Using a Modified Inductive Transducer

Directory of Open Access Journals (Sweden)

Samik MARICK

2014-11-01

Full Text Available Float type liquid level sensor is generally used as a very simple technique for local level indication and level switching. In the present paper a technique has been proposed to transmit the measured liquid level signal of a float type sensor at remote terminal using a modified differential inductance type electromechanical transducer. The theoretical characteristic equation of this transducer has been derived. A prototype unit of the transducer has been developed and fabricated and its performance characteristic has been experimentally determined. The experimental results are reported in the paper. From experimental data, a very good linear characteristic of the proposed level transducer has been observed.

Type 1,1-operators defined by vanishing frequency modulation

DEFF Research Database (Denmark)

Johnsen, Jon

This paper presents a general definition of pseudo-differential operators of type 1,1; the definition is shown to be the largest one that is both compatible with negligible operators and stable under vanishing frequency modulation. Elaborating counter-examples of Ching andHörmander, type 1...

Importance of thermal radiation from heat sink in cooling of three phase PWM inverter kept inside an evacuated chamber

Directory of Open Access Journals (Sweden)

Anjan Sarkar

2017-04-01

Full Text Available The paper describes a thermal analysis of a three-phase inverter operated under a Sinusoidal Pulse Width Modulation (SPWM technique which used three sine waves displaced in 120° phase difference as reference signals. The IGBT unit is assumed to be placed with a heat sink inside an evacuated chamber and the entire heat has to be transferred by conduction and radiation. The main heat sources present here are the set of IGBTs and diodes which generates heat on a pulse basing on their switching frequencies. Melcosim (a well-known tool developed by Mitsubishi Electric Corporation has been used to generate the power pulse from one set of IGBT and diode connected to a phase. A Scilab code is written to study the conduction and thermal radiation of heat sink and their combined effect on transient growth of the junction temperature of IGBT unit against complex switching pulses. The results mainly show that how thermal radiation from heat sink plays a crucial role in maintaining the junction temperature of IGBT within a threshold limit by adjusting various heat sink parameters. As the IGBT heat generation rate becomes higher, radiative heat transfer of the heat sink increases sharply which enhances overall cooling performance of the system.

Global (volume-averaged) model of inductively coupled chlorine plasma : influence of Cl wall recombination and external heating on continuous and pulse-modulated plasmas

NARCIS (Netherlands)

Kemaneci, E.H.; Carbone, E.A.D.; Booth, J.P.; Graef, W.A.A.D.; Dijk, van J.; Kroesen, G.M.W.

An inductively coupled radio-frequency plasma in chlorine is investigated via a global (volume-averaged) model, both in continuous and square wave modulated power input modes. After the power is switched off (in a pulsed mode) an ion–ion plasma appears. In order to model this phenomenon, a novel

High Voltage, Fast-Switching Module for Active Control of Magnetic Fields and Edge Plasma Currents

Science.gov (United States)

Ziemba, Timothy; Miller, Kenneth; Prager, James; Slobodov, Ilia

2016-10-01

Fast, reliable, real-time control of plasma is critical to the success of magnetic fusion science. High voltage and current supplies are needed to mitigate instabilities in all experiments as well as disruption events in large scale tokamaks for steady-state operation. Silicon carbide (SiC) MOSFETs offer many advantages over IGBTs including lower drive energy requirements, lower conduction and switching losses, and higher switching frequency capabilities; however, these devices are limited to 1.2-1.7 kV devices. As fusion enters the long-pulse and burning plasma eras, efficiency of power switching will be important. Eagle Harbor Technologies (EHT), Inc. developing a high voltage SiC MOSFET module that operates at 10 kV. This switch module utilizes EHT gate drive technology, which has demonstrated the ability to increase SiC MOSFET switching efficiency. The module will allow more rapid development of high voltage switching power supplies at lower cost necessary for the next generation of fast plasma feedback and control. EHT is partnering with the High Beta Tokamak group at Columbia to develop detailed high voltage module specifications, to ensure that the final product meets the needs of the fusion science community.

Design and development of line type modulators for high impedance electron gun

Energy Technology Data Exchange (ETDEWEB)

Dixit, Kavita P.; Tillu, Abhijit; Chavan, Ramchandra; Yadav, Vivek; Sarukte, Hemant, E-mail: kavidi@barc.gov.in [Accelerator and Pulse Power Division, Bhabha Atomic Research Centre, Mumbai (India)

2014-07-01

Conventional line type modulators are routinely used for powering pulsed power microwave devices such as magnetrons and klystrons used for radar, medical and scientific applications. The load impedance (operating point) is fairly well defined in these cases, and makes the design of the discharging circuit of the modulator straight forward. This paper describes the Line type modulators that have been developed and being routinely used for powering the Triode Electron Gun of industrial electron linacs. The beam parameters of such guns are user defined and the pulse current varies from few mA to 800mA (typ). The beam energies requirement varies from 40 keV to 80 keV. Hence the impedance offered by the electron gun to the power source (modulator) is not well defined. The load capacitance which is inclusive of the various stray capacitances along with the intrinsic gun capacitance is ∼ 200-400 pF. This capacitance, which depends on the configuration, shunts the load and makes the effective load highly capacitive with the resistive part varying over a wide range. The paper describes the design and development of conventional line type modulators for powering Electron gun load of the type described above. (author)

High power n-type metal-wrap-through cells and modules using industrial processes

Energy Technology Data Exchange (ETDEWEB)

Guillevin, N.; Heurtault, B.J.B.; Geerligs, L.J.; Van Aken, B.B.; Bennett, I.J.; Jansen, M.J.; Weeber, A.W.; Bultman, J.H. [ECN Solar Energy, P.O. Box 1, NL-1755 ZG Petten (Netherlands); Jianming, Wang; Ziqian, Wang; Jinye, Zhai; Zhiliang, Wan; Shuquan, Tian; Wenchao, Zhao; Zhiyan, Hu; Gaofei, Li; Bo, Yu; Jingfeng, Xiong [Yingli Green Energy Holding Co.,Ltd. 3399 North Chaoyang Avenue, Baoding (China)

2013-10-15

This paper reviews our recent progress in the development of metal wrap through (MWT) cells and modules, produced from n-type Czochralski silicon wafers. The use of n-type silicon as base material allows for high efficiencies: for front emitter-contacted industrial cells, efficiencies above 20% have been reported. N-type MWT (nMWT) cells produced by industrial process technologies allow even higher efficiency due to reduced front metal coverage. Based on the same industrial technology, the efficiency of the bifacial n-MWT cells exceeds the efficiency of the n-type front-and-rear contact and bifacial 'Pasha' technology (n-Pasha) by 0.1-0.2% absolute, with a maximum nMWT efficiency of 20.1% so far. Additionally, full back-contacting of the MWT cells in a module results in reduced cell to module (CTM) fill factor losses. In a direct 60-cell module performance comparison, the n-MWT module, based on integrated backfoil, produced 3% higher power output than the comparable tabbed front emitter-contacted n-Pasha module. Thanks to reduced resistive losses in copper circuitry on the backfoil compared to traditional tabs, the CTM FF loss of the MWT module was reduced by about 2.2%abs. compared to the tabbed front emitter contact module. A full-size module made using MWT cells of 19.6% average efficiency resulted in a power output close to 280W. Latest results of the development of the n-MWT technology at cell and module level are discussed in this paper, including a recent direct comparison run between n-MWT and n-Pasha cells and results of n-MWT cells from 140{mu}m thin mono-crystalline wafers, with only very slight loss (1% of Isc) for the thin cells. Also reverse characteristics and effects of reverse bias for extended time at cell and module level are reported, where we find a higher tolerance of MWT modules than tabbed front contact modules for hotspots.

Satellite III non-coding RNAs show distinct and stress-specific patterns of induction

International Nuclear Information System (INIS)

Sengupta, Sonali; Parihar, Rashmi; Ganesh, Subramaniam

2009-01-01

The heat shock response in human cells is associated with the transcription of satellite III repeats (SatIII) located in the 9q12 locus. Upon induction, the SatIII transcripts remain associated with the locus and recruit several transcription and splicing factors to form the nuclear stress bodies (nSBs). The nSBs are thought to modulate epigenetic changes during the heat shock response. We demonstrate here that the nSBs are induced by a variety of stressors and show stress-specific patterns of induction. While the transcription factor HSF1 is required for the induction of SatIII locus by the stressors tested, its specific role in the transcriptional process appears to be stress dependent. Our results suggest the existence of multiple transcriptional loci for the SatIII transcripts and that their activation might depend upon the type of stressors. Thus, induction of SatIII transcripts appears to be a generic response to a variety of stress conditions.

A COMPARATIVE ANALYSIS OF PROCESSES IN AN INDEPENDENT GENERATOR WITH A NONCONTACT CASCADE THREE-PHASE MODULATED EXCITER VIA A STAR-CONNECTED CIRCUIT UNDER ACTIVE-INDUCTIVE LOADING

Directory of Open Access Journals (Sweden)

K.M. Vasyliv

2013-02-01

Full Text Available By means of mathematical experiment, the author investigates electromagnetic and electromechanical processes in an independent electric power supply system based on an asynchronized generator with a three-phase modulated exciter. The processes are analyzed to specify the working capacity of the power supply system during its operation under active-inductive loading. Regularities of the electromagnetic and electromechanical processes behavior versus load intensity and the modulator scheme are identified.

Study on the Effects of the Modulator Output Ripple on the RF System of the KOMAC 100-MeV Proton Linear Accelerator

Energy Technology Data Exchange (ETDEWEB)

Kwon, Hyeok Jung; Kim, Han Sung; Seol, Kyung Tae; Jeong, Hae Sung; Kim, Sung Gu; Cho, Yong Sub [KAERI, Daejeon (Korea, Republic of)

2016-05-15

The high power system of the proton linear accelerator consists of accelerating cavities such as Radio Frequency Quadrupole (RFQ) and Drift Tube Linac (DTL), high power radio frequency (RF) systems such as klystrons, RF transmission lines and modulators as a klystron power supply. The modulator used at KOMAC adopted a high frequency switching technology using a 3-phase full bridge converter topology to produce 5.8 MW peak power at -105 kV with 9 % duty and produces a current ripple corresponding to the harmonics of the switching frequency. In this paper, the output ripple from the modulator is analyzed and its effects on the high power RF system are presented. The ripple current of the modulator was measured and analyzed. The higher harmonics of the switching frequency were measured and the dominant one was the third harmonic. And this ripple had an effect on the RF signal which was amplified through the klystron and delivered to the DTL. The dominant ripple component of the RF signal was also the third harmonics of the IGBT switching frequency of the modulator.

Influenza A virus inhibits type I IFN signaling via NF-kappaB-dependent induction of SOCS-3 expression.

Directory of Open Access Journals (Sweden)

Eva-K Pauli

2008-11-01

Full Text Available The type I interferon (IFN system is a first line of defense against viral infections. Viruses have developed various mechanisms to counteract this response. So far, the interferon antagonistic activity of influenza A viruses was mainly observed on the level of IFNbeta gene induction via action of the viral non-structural protein 1 (NS1. Here we present data indicating that influenza A viruses not only suppress IFNbeta gene induction but also inhibit type I IFN signaling through a mechanism involving induction of the suppressor of cytokine signaling-3 (SOCS-3 protein. Our study was based on the observation that in cells that were infected with influenza A virus and subsequently stimulated with IFNalpha/beta, phosphorylation of the signal transducer and activator of transcription protein 1 (STAT1 was strongly reduced. This impaired STAT1 activation was not due to the action of viral proteins but rather appeared to be induced by accumulation of viral 5' triphosphate RNA in the cell. SOCS proteins are potent endogenous inhibitors of Janus kinase (JAK/STAT signaling. Closer examination revealed that SOCS-3 but not SOCS-1 mRNA levels increase in an RNA- and nuclear factor kappa B (NF-kappaB-dependent but type I IFN-independent manner early in the viral replication cycle. This direct viral induction of SOCS-3 mRNA and protein expression appears to be relevant for suppression of the antiviral response since in SOCS-3 deficient cells a sustained phosphorylation of STAT1 correlated with elevated expression of type I IFN-dependent genes. As a consequence, progeny virus titers were reduced in SOCS-3 deficient cells or in cells were SOCS-3 expression was knocked-down by siRNA. These data provide the first evidence that influenza A viruses suppress type I IFN signaling on the level of JAK/STAT activation. The inhibitory effect is at least in part due to the induction of SOCS-3 gene expression, which results in an impaired antiviral response.

Capacitor Current Feedback-Based Active Resonance Damping Strategies for Digitally-Controlled Inductive-Capacitive-Inductive-Filtered Grid-Connected Inverters

Directory of Open Access Journals (Sweden)

Iman Lorzadeh

2016-08-01

Full Text Available Inductive-capacitive-inductive (LCL-type line filters are widely used in grid-connected voltage source inverters (VSIs, since they can provide substantially improved attenuation of switching harmonics in currents injected into the grid with lower cost, weight and power losses than their L-type counterparts. However, the inclusion of third order LCL network complicates the current control design regarding the system stability issues because of an inherent resonance peak which appears in the open-loop transfer function of the inverter control system near the control stability boundary. To avoid passive (resistive resonance damping solutions, due to their additional power losses, active damping (AD techniques are often applied with proper control algorithms in order to damp the LCL filter resonance and stabilize the system. Among these techniques, the capacitor current feedback (CCF AD has attracted considerable attention due to its effective damping performance and simple implementation. This paper thus presents a state-of-the-art review of resonance and stability characteristics of CCF-based AD approaches for a digitally-controlled LCL filter-based grid-connected inverter taking into account the effect of computation and pulse width modulation (PWM delays along with a detailed analysis on proper design and implementation.

Development of a current-type PWM converter with high power factor. 1

International Nuclear Information System (INIS)

Miura, Yushi; Matsukawa, Makoto; Miyachi, Kengo; Kimura, Toyoaki

1998-01-01

A power supply system for superconducting poloidal field coils of a next generation tokamak-type fusion device can be operated on the relatively low voltage for the duration of discharge except the plasma initiation. In the case of the conventional phase-controlled thyristor converters are adopted in such a system, the input power factor would be low in average, and a reactive power fluctuation caused by the change of DC output voltage may produce serious effects on the commercial transmission line. From the above viewpoint, a current-type PWM (Pulse Width Modulation) converter, which can work with the power factor of unity for the input power, is regarded as one of the promising candidates of the converters for the power supplies of next generation fusion devices. Hence, a 100kW-class current-type PWM converter has been developed by using IGBT (Insulated Gate Bipolar Transistor) as switching devices. In this development, the basic performance has been preliminary investigated whether this converter is applicable to the power supply for the next generation fusion device. In addition, two different PWM control methods were examined whether these methods can realize a unit power factor and suppress the transient oscillation of converter input current at the same time in case that the reference of DC output current is changed rapidly. (author)

Novel rotating characteristics of a squirrel-cage-type HTS induction/synchronous motor

International Nuclear Information System (INIS)

Nakamura, T; Ogama, Y; Miyake, H; Nagao, K; Nishimura, T

2007-01-01

This paper describes the rotating characteristics of a high-T c superconducting induction/synchronous motor, which possesses both asynchronous and synchronous torques even though its structure is exactly the same as the squirrel-cage-type induction motor. Two kinds of Bi-2223/Ag multifilamentary tapes were utilized for the secondary windings. A commercialized motor (1.5 kW) was subjected to this study. A conventional (normal conducting) stator (three-phase, four-pole) was directly utilized, and only the squirrel-cage windings were replaced with the superconducting tapes. The tests were performed after the fabricated motor was immersed in liquid nitrogen. The operating temperature was also varied by pumping out the liquid nitrogen. It is shown that the motor is successfully synchronized for the temperature range from 65 to 77 K. Detailed discussions for such novel rotating characteristics are reported based on the electrical equivalent circuit

A large amount synthesis of nanopowder using modulated induction thermal plasmas synchronized with intermittent feeding of raw materials

International Nuclear Information System (INIS)

Tanaka, Y; Tsuke, T; Guo, W; Uesugi, Y; Ishijima, T; Watanabe, S; Nakamura, K

2012-01-01

A large amount synthesis method for titanium dioxide (TiO 2 ) nanopowder is proposed by direct evaporation of titanium powders using Ar-O 2 pulse-modulated induction thermal plasma (PMITP). To realize a large amount synthesis of nanopowder, the PMITP method was combined with the intermittent and heavy load feeding of raw material powder, as well as the quenching gas injection. The intermittent powder feeding was synchronized with the modulation of the coil current sustaining the PMITP for complete evaporation of the injected powder. Synthesized particles by the developed method were analyzed by FE-SEM and XRD. Results indicated that the synthesized particles by the 20-kW PMITP with a heavy loading rate of 12.3 g min −1 had a similar particle size distribution with the mean diameter about 40 nm to those with light loading of 4.2 g min −1 .

Comparison of a state of the art Si IGBT and next generation fast switching devices in a 4 kW boost converter

DEFF Research Database (Denmark)

Anthon, Alexander; Zhang, Zhe; Andersen, Michael A. E.

2015-01-01

This paper gives a comprehensive comparison of two promising silicon carbide (SiC) switching devices, i.e. normally-off SiC MOSFET and a normally-on SiC JFET, as alternatives to a conventional state of the art Si IGBT. The comparison uses datasheet information to determine conduction losses, swit...... losses. This reduction in semiconductor losses can increase overall converter efficiencies up to 0.4% at 20kHz or enable high frequency operation up to 100 kHz which then reduces the size and weight of the inductor by more than 75% while still achieving efficiencies over 98.3 %....

Inductive Reasoning and Writing

Science.gov (United States)

Rooks, Clay; Boyd, Robert

2003-01-01

Induction, properly understood, is not merely a game, nor is it a gimmick, nor is it an artificial way of explaining an element of reasoning. Proper understanding of inductive reasoning--and the various types of reasoning that the authors term inductive--enables the student to evaluate critically other people's writing and enhances the composition…

Vaginal type-II mucosa is an inductive site for primary CD8+ T-cell mucosal immunity

Science.gov (United States)

Wang, Yichuan; Sui, Yongjun; Kato, Shingo; Hogg, Alison E.; Steel, Jason C.; Morris, John C.; Berzofsky, Jay A.

2014-01-01

The structured lymphoid tissues are considered the only inductive sites where primary T cell immune responses occur. The naïve T cells in structured lymphoid tissues, once being primed by antigen -bearing dendritic cells, differentiate into memory T cells and traffic back to the mucosal sites through the bloodstream. Contrary to this belief, here we show that the vaginal type-II mucosa itself, despite lack of structured lymphoid tissues, can act as an inductive site during primary CD8+ T cell immune responses. We provide evidence that the vaginal mucosa supports both the local immune priming of naïve CD8+ T cells and the local expansion of antigen-specific CD8+ T cells, thereby demonstrating a different paradigm for primary mucosal T cell immune induction. PMID:25600442

The effect of the novel internal-type linear inductive antenna for large area magnetized inductive plasma source

Science.gov (United States)

Lee, S. H.; Shulika, Olga.; Kim, K. N.; Yeom, G. Y.; Lee, J. K.

2004-09-01

As the technology of plasma processing progresses, there is a continuing demand for higher plasma density, uniformity over large areas and greater control over plasma parameters to optimize the processes of etching, deposition and surface treatment. Traditionally, the external planar ICP sources with low pressure high density plasma have limited scale-up capabilities due to its high impedance accompanied by the large antenna size. Also due to the cost and thickness of their dielectric material in order to generate uniform plasma. In this study the novel internal-type linear inductive antenna system (1,020mm¡¿830mm¡¿437mm) with permanent magnet arrays are investigated to improve both the plasma density and the uniformity of LAPS (Large Area Plasma Source) for FPD processing. Generally plasma discharges are enhanced because the inductance of the novel antenna (termed as the double comb antenna) is lower than that of the serpentine-type antenna and also the magnetic confinement of electron increases the power absorption efficiency. The uniformity is improved by reducing the standing wave effect. The total length of antenna is comparable to the driving rf wavelength to cause the plasma nonuniformity. To describe the discharge phenomenon we have developed a magnetized two-dimensional fluid simulation. This work was supported by National Research Laboratory (NRL) Program of the Korea Ministry of Science and Technology. [References] 1. J.K.Lee, Lin Meng, Y.K.Shin, H,J,Lee and T.H.Chung, ¡°Modeling and Simulation of a Large-Area Plasma Source¡±, Jpn. J. Appl. Phys. Vol.36(1997) pp. 5714-5723 2. S.E.Park, B.U.Cho, Y.J.Lee*, and G.Y.Yeom*, and J.K.Lee, ¡°The Characteristics of Large Area Processing Plasmas¡±, IEEE Trans. Plasma Sci., Vol.31 ,No.4(2003) pp. 628-637

A Modified Multiband Hysteresis Controlled DTC of Induction Machine with 27-level asymmetrical CHB-MLI with NVC modulation

Directory of Open Access Journals (Sweden)

Rohith Balaji Jonnala

2018-03-01

Full Text Available The influence of Direct Torque Controlled Induction Motor Drive in the area of industrial application is very high; it presents foremost area of controllability of load at different states of operation. The major snags to the controller are maintaining Constant Switching Frequency and Infeasibility state. This paper concentrates on rectifying these problems with Modified Multiband Hysteresis Controller and Nearest Vector Control Modulated Asymmetrical Cascaded H-Bridge Multilevel Inverter for the better drive operation. In this case proper modification in MHC gives the optimal utilizations of each control vector to avoid the infeasibility states with a Lookup-Table and Multilevel Inverter gives more number of control voltage vectors with constant switching frequency for flexible operation of drive with low disturbances. Direct Torque Control equipped with these two modules achieves better operating conditions with low Torque ripples, low distorted flux and speed with different loads, and all other satisfactory load operating parameters.

Junction temperature estimation method for a 600 V, 30A IGBT module during converter operation

DEFF Research Database (Denmark)

Choi, U. M.; Blaabjerg, F.; Iannuzzo, F.

2015-01-01

This paper proposes an accurate method to estimate the junction temperature using the on-state collector-emitter voltage at high current. By means of the proposed method, the estimation error which comes from the different temperatures of the interconnection materials in the module is compensated....... Finally, it leads to satisfactory estimated results. The proposed method has been verified by means of an IR (Infra-Red) camera during power converter operations when the loading current is sinusoidal....

Mission profile resolution effects on lifetime estimation of doubly-fed induction generator power converter

DEFF Research Database (Denmark)

Zhang, Guanguan; Zhou, Dao; Blaabjerg, Frede

2017-01-01

, and the corresponding thermal modeling of power semiconductors are discussed. Accordingly, effects of different mission profiles on the consumed lifetime of the power converter are evaluated. In the above three thermal cycles, the IGBT of the grid-side converter and the diode of the rotor-side converter are more...... fragile, and the total consumed lifetimes are higher. Moreover, the short-term thermal cycles with milliseconds resolution induce the unbalance of the lifetime between the diode and IGBT of the grid-side converter, while thermal cycles with hour, second, and millisecond resolution consumes the similar......In the wind energy generation system, mission profiles are complicated, which range from seconds to years. In order to estimate the consumed lifetime of the power converter, wind speed profiles with the time resolution of 1 hour, 1 second and 0.5 millisecond are studied in this paper...

Parallel Connection of Silicon Carbide MOSFETs for Multichip Power Modules

DEFF Research Database (Denmark)

Li, Helong

challenges from the manufacture and application points of view. The less mature manufacture process limits the yield and the single die size of the SiC MOSFETs, which results a smaller current capability of a single SiC MOSFET die. Consequently, in high current application, the paralleled connections of Si...... connections for the paralleled dies are presented and the source of the transient current imbalance is concluded. To mitigate the transient current imbalance in the traditional DBC layout, a novel DBC layout with split output is proposed. First, the working mechanism of the split output topology is studied...... the current sharing performance among the paralleled SiC MOSFET dies in the power module. The proposed DBC layout is not only limited for SiC MOSFETs, but also for Si IGBTs and other voltage controlled devices. of the circuit mismatch on the paralleled connection of SiC MOSFETs. It reveals the circuit...

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription.

Directory of Open Access Journals (Sweden)

Baca Chan

2017-05-01

Full Text Available The type I interferon (IFN response is imperative for the establishment of the early antiviral immune response. Here we report the identification of the first type I IFN antagonist encoded by murine cytomegalovirus (MCMV that shuts down signaling following pattern recognition receptor (PRR sensing. Screening of an MCMV open reading frame (ORF library identified M35 as a novel and strong negative modulator of IFNβ promoter induction following activation of both RNA and DNA cytoplasmic PRR. Additionally, M35 inhibits the proinflammatory cytokine response downstream of Toll-like receptors (TLR. Using a series of luciferase-based reporters with specific transcription factor binding sites, we determined that M35 targets NF-κB-, but not IRF-mediated, transcription. Expression of M35 upon retroviral transduction of immortalized bone marrow-derived macrophages (iBMDM led to reduced IFNβ transcription and secretion upon activation of stimulator of IFN genes (STING-dependent signaling. On the other hand, M35 does not antagonize interferon-stimulated gene (ISG 56 promoter induction or ISG transcription upon exogenous stimulation of the type I IFN receptor (IFNAR. M35 is present in the viral particle and, upon MCMV infection of fibroblasts, is immediately shuttled to the nucleus where it exerts its immunomodulatory effects. Deletion of M35 from the MCMV genome and hence from the viral particle resulted in elevated type I IFN transcription and secretion in vitro and in vivo. In the absence of M35, lower viral titers are observed during acute infection of the host, and productive infection in the salivary glands was not detected. In conclusion, the M35 protein is released by MCMV immediately upon infection in order to deftly inhibit the antiviral type I IFN response by targeting NF-κB-mediated transcription. The identification of this novel viral protein reinforces the importance of timely countermeasures in the complex relationship between virus and host.

Power density investigations for the large wind turbines' grid-side press-pack IGBT 3L-NPC-VSCs

DEFF Research Database (Denmark)

Senturk, Osman Selcuk; Helle, Lars; Munk-Nielsen, Stig

2012-01-01

-thermal models are required to be derived, implemented, and utilized. In this study, employed as a grid-side medium voltage full-scale voltage source converters (VSCs) in a multi-MW wind turbine, press-pack IGBT three-level neutral-point-clamped VSC (3L-NPC-VSC), 3L active NPC-VSC (3L-ANPC-VSC), and 3L neutral......Power density is the important design criterion in wind turbine converter design provided that satisfactory converter performance is guaranteed. In order to assess a converter in terms of power density, which is dependent on converter electrical and thermal behaviors, converter electro......-point-piloted VSC (3L-NPP-VSC) are characterized in terms of converter operating principles, physical structure, power loss, and DC bus capacitor size for establishing the basis for converter electro-thermal modeling. Via the practical implementations of the converter electro-thermal models in a computation...

Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections

Directory of Open Access Journals (Sweden)

Deann T. Snyder

2017-01-01

Full Text Available Type I interferons represent a unique and complex group of cytokines, serving many purposes during innate and adaptive immunity. Discovered in the context of viral infections, type I IFNs are now known to have myriad effects in infectious and autoimmune disease settings. Type I IFN signaling during bacterial infections is dependent on many factors including whether the infecting bacterium is intracellular or extracellular, as different signaling pathways are activated. As such, the repercussions of type I IFN induction can positively or negatively impact the disease outcome. This review focuses on type I IFN induction and downstream consequences during infection with the following intracellular bacteria: Chlamydia trachomatis, Listeria monocytogenes, Mycobacterium tuberculosis, Salmonella enterica serovar Typhimurium, Francisella tularensis, Brucella abortus, Legionella pneumophila, and Coxiella burnetii. Intracellular bacterial infections are unique because the bacteria must avoid, circumvent, and even co-opt microbial “sensing” mechanisms in order to reside and replicate within a host cell. Furthermore, life inside a host cell makes intracellular bacteria more difficult to target with antibiotics. Because type I IFNs are important immune effectors, modulating this pathway may improve disease outcomes. But first, it is critical to understand the context-dependent effects of the type I IFN pathway in intracellular bacterial infections.

Comparison on Promotion Effect of Various Types of Surfactants on HCFC-141b Hydrate Induction Time

Science.gov (United States)

Li, Juan; Sun, Zhigao; Liu, Chenggang; Zhu, Minggui

2018-03-01

Cold storage in air conditioning based on refrigerant hydrate is a new-type energy saving technology to reduce initial investment and running cost of air conditioning equipments and improve system stability. Refrigerant hydrate is generated under critical temperature and pressure condition, while surfactant is an effective medium to promote its phase equilibrium. In this paper, in order to research such promotion effect, different type of surfactants with unique mechanism, SDS, Tween80 and Span80, n-BA were selected to compare the respective impact on HCFC141b hydrate induction time based on temperature curve. Experimental results showed that no obvious change had been discovered when no surfactant was added into pure water system, which coincided with phase equilibrium diagram of HCFC141b. All the four kinds of surfactants had realized promotion effect to various degrees. For each hydration system, a large gap existed between the longest and the shortest induction time in 6 groups of parallel experiments, meaning relatively poor system stability. Under the combined effect of Tween80 (2wt%), Span80 (0.1wt%) and n-BA (0.1wt%), average and the shortest induction time was 20.9min and 17.5min respectively, corresponding to the best promotion effect.

Recent Upgrade of the Klystron Modulator at SLAC

International Nuclear Information System (INIS)

Nguyen, M.N.; Burkhart, C.P.; Lam, B.K.; Morris, B.

2011-01-01

The SLAC National Accelerator Laboratory employs 244 klystron modulators on its two-mile-long linear accelerator that has been operational since the early days of the SLAC establishment in the sixties. Each of these original modulators was designed to provide 250 kV, 262 A and 3.5 μS at up to 360 pps using an inductance-capacitance resonant charging system, a modified type-E pulse-forming network (PFN), and a pulse transformer. The modulator internal control comprised of large step-start resistor-contactors, vacuum-tube amplifiers, and 120 Vac relays for logical signals. A major, power-component-only upgrade, which began in 1983 to accommodate the required beam energy of the SLAC Linear Collider (SLC) project, raised the modulator peak output capacity to 360 kV, 420 A and 5.0 μS at a reduced pulse repetition rate of 120 pps. In an effort to improve safety, performance, reliability and maintainability of the modulator, this recent upgrade focuses on the remaining three-phase AC power input and modulator controls. The upgrade includes the utilization of primary SCR phase control rectifiers, integrated fault protection and voltage regulation circuitries, and programmable logic controllers (PLC) -- with an emphasis on component physical layouts for safety and maintainability concerns. In this paper, we will describe the design and implementation of each upgraded component in the modulator control system. We will also report the testing and present status of the modified modulators.

Scaling the Serialization of MOSFETs by Magnetically Coupling Their Gate Electrodes

DEFF Research Database (Denmark)

Dimopoulos, Emmanouil; Munk-Nielsen, Stig

2013-01-01

More than twenty years of thorough research on the serialization of power semiconductor switches, like the Metal-Oxide-Semiconductor Field Effect Transistor (MOSFET) or the Insulated Gate Bipolar Transistor (IGBT), have resulted into several different stacking concepts; all aiming towards...... the establishment of a high-efficient, high-voltage, fast-switching device. Among the prevailing stacking approaches lies the gate balancing core technique, which, in its initial form, demonstrated very good performance in strings of high-power IGBT modules, by magnetically coupling their gate electrodes. Recently...

Induction of Human Squamous Cell-Type Carcinomas by Arsenic

International Nuclear Information System (INIS)

Martinez, V. D.; Becker-Santos, D. D.; Vucic, E. A.; Lam, S.; Lam, W. L.

2011-01-01

Arsenic is a potent human carcinogen. Around one hundred million people worldwide have potentially been exposed to this metalloid at concentrations considered unsafe. Exposure occurs generally through drinking water from natural geological sources, making it difficult to control this contamination. Arsenic biotransformation is suspected to have a role in arsenic-related health effects ranging from acute toxicities to development of malignancies associated with chronic exposure. It has been demonstrated that arsenic exhibits preference for induction of squamous cell carcinomas in the human, especially skin and lung cancer. Interestingly, keratins emerge as a relevant factor in this arsenic-related squamous cell-type preference. Additionally, both genomic and epi genomic alterations have been associated with arsenic-driven neoplastic process. Some of these aberrations, as well as changes in other factors such as keratins, could explain the association between arsenic and squamous cell carcinomas in humans.

Type 1,1-operators defined by vanishing frequency modulation

DEFF Research Database (Denmark)

Johnsen, Jon

2009-01-01

This paper presents a general definition of pseudo-differential operators of type 1,1; the definition is shown to be the largest one that is both compatible with negliible operators and stable under vanishing frequency modulation. Elaborating counter-examples of Ching, Hörmander and Parenti...

A high-current racetrack induction accelerator

International Nuclear Information System (INIS)

Mondelli, A.; Roberson, C.W.

1983-01-01

In this paper, the energy and system scaling laws of the Racetrack Induction Accelerator are determined and its operating principles are discussed. This device is a cyclic accelerator that is capable of multi-kiloamp operation. Long pulse induction linac technology is used to obtain short acceleration times. The accelerator consists of a long-pulse linear induction module and a racetrack beam transport system. For detailed studies of the particle dynamics in a racetrack, a numerical model is required to integrate the fully-relativistic single-particle equations of motion in an externally applied magnetic field. The numerical model is a compromise between the need for a large rotational transform and the need for a reasonable volume within the separatrix

New type of magnetohydrodynamic converters: induction devices

International Nuclear Information System (INIS)

Petit, J.-P.; Viton, Maurice.

1977-01-01

A new induction MHD accelerator, disc shaped, with controlled ionization, is presented. Associated with a light and powerful electric generator it could become a MHD aerodyne. Solutions for confining the plasma to the wall are indicated [fr

Stability Analysis of a Matrix Converter Drive: Effects of Input Filter Type and the Voltage Fed to the Modulation Algorithm

Directory of Open Access Journals (Sweden)

M. Hosseini Abardeh

2015-03-01

Full Text Available The matrix converter instability can cause a substantial distortion in the input currents and voltages which leads to the malfunction of the converter. This paper deals with the effects of input filter type, grid inductance, voltage fed to the modulation algorithm and the synchronous rotating digital filter time constant on the stability and performance of the matrix converter. The studies are carried out using eigenvalues of the linearized system and simulations. Two most common schemes for the input filter (LC and RLC are analyzed. It is shown that by a proper choice of voltage input to the modulation algorithm, structure of the input filter and its parameters, the need for the digital filter for ensuring the stability can be resolved. Moreover, a detailed model of the system considering the switching effects is simulated and the results are used to validate the analytical outcomes. The agreement between simulation and analytical results implies that the system performance is not deteriorated by neglecting the nonlinear switching behavior of the converter. Hence, the eigenvalue analysis of the linearized system can be a proper indicator of the system stability.

Urofollitropin and ovulation induction

NARCIS (Netherlands)

van Wely, Madelon; Yding Andersen, Claus; Bayram, Neriman; van der Veen, Fulco

2005-01-01

Anovulation is a common cause of female infertility. Treatment for women with anovulation is aimed at induction of ovulation. Ovulation induction with follicle-stimulating hormone (FSH) is indicated in women with WHO type II anovulation in whom treatment with clomifene citrate (clomifene) has

Compact Digital High Voltage Charger

CERN Document Server

Li, Ge

2005-01-01

The operation of classical resonant circuit developed for the pulse energizing is investigated. The HV pulse or generator is very compact by a soft switching circuit made up of IGBT working at over 30 kHZ. The frequencies of macro pulses andμpulses can be arbitrarily tuned below resonant frequency to digitalize the HV pulse power. Theμpulses can also be connected by filter circuit to get the HVDC power. The circuit topology is given and its novel control logic is analyzed by flowchart. The circuit is part of a system consisting of a AC or DC LV power supply, a pulse transformer, the pulse generator implemented by LV capacitor and leakage inductance of the transformer, a HV DC or pulse power supply and the charged HV capacitor of the modulators.

Induction of hairy roots by various strains of Agrobacterium rhizogenes in different types of Capsicum species explants.

Science.gov (United States)

Md Setamam, Nursuria; Jaafar Sidik, Norrizah; Abdul Rahman, Zainon; Che Mohd Zain, Che Radziah

2014-06-30

Capsicum annuum and Capsicum frutescens, also known as "chilies", belong to the Solanaceae family and have tremendous beneficial properties. The application of hairy root culture may become an alternative method for future development of these species by adding value, such as by increasing secondary metabolites and improving genetic and biochemical stability compared with normal Capsicum plants. Therefore, in this research, different types of explants of both species were infected with various Agrobacterium rhizogenes strains to provide more information about the morphology and induction efficiency of hairy roots. After 2 weeks of in vitro seed germination, young seedling explants were cut into three segments; the cotyledon, hypocotyl, and radical. Then, the explants were co-cultured with four isolated A. rhizogenes strains in Murashige & Skoog culture media (MS) containing decreasing carbenicillin disodium concentrations for one month. In this experiment, thick and short hairy roots were induced at all induction sites of C. annuum while thin, elongated hairy roots appeared mostly at wound sites of C. frutescens. Overall, the hairy root induction percentages of C. frutescens were higher compared with C. annuum. Hairy root initiation was observed earliest using radicles (1st week), followed by cotyledons (2nd week), and hypocotyls (3rd week). Cotyledon explants of both species had the highest induction frequency with all strains compared with the other explants types. Strains ATCC 13333 and ATCC 15834 were the most favourable for C. frutescens while ATCC 43056 and ATCC 43057 were the most favourable for C. annuum. The interactions between the different explants and strains showed significant differences with p-values Capsicum species. Both Capsicum species were amenable to A. rhizogenes infection and hairy root induction is recommended for use as an alternative explants in future plant-based studies.

Linear induction accelerators

International Nuclear Information System (INIS)

Briggs, R.J.

1986-06-01

The development of linear induction accelerators has been motivated by applications requiring high-pulsed currents of charged particles at voltages exceeding the capability of single-stage, diode-type accelerators and at currents too high for rf accelerators. In principle, one can accelerate charged particles to arbitrarily high voltages using a multi-stage induction machine, but the 50-MeV, 10-kA Advanced Test Accelerator (ATA) at LLNL is the highest voltage machine in existence at this time. The advent of magnetic pulse power systems makes sustained operation at high-repetition rates practical, and this capability for high-average power is very likely to open up many new applications of induction machines in the future. This paper surveys the US induction linac technology with primary emphasis on electron machines. A simplified description of how induction machines couple energy to the electron beam is given, to illustrate many of the general issues that bound the design space of induction linacs

ANALYSIS OF PROCESSES IN AN INDEPENDENT GENERATOR WITH A NONCONTACT CASCADE THREE-PHASE MODULATED EXCITER VIA A STAR-CONNECTED CIRCUIT WITH A COMMON MODULATOR PHASE CONNECTION UNDER OPERATION TO AN INDUCTION MOTORS SITE

Directory of Open Access Journals (Sweden)

K.M. Vasyliv

2013-04-01

Full Text Available By means of a mathematical experiment, electromagnetic and electromechanical processes in an independent electric power supply system based on an asynchronized generator with a three-phase modulated exciter are investigated. The processes are analyzed to specify the working capacity of the power supply system during its operation to an induction motors site. Regularities of the electromagnetic and electromechanical processes behavior versus load intensity and the switch control system parameters are identified.

Induction Acceleration of a Single RF Bunch in the KEK PS

CERN Document Server

Takayama, Ken; Arakida, Yoshio; Horioka, Kazuhiko; Igarashi, Susumu; Iwashita, Taiki; Kawasaki, Atsushi; Kishiro, Junichi; Kono, Tadaaki; Koseki, Kunio; Nakamura, Eiji; Sakuda, Makoto; Sato, Hikaru; Shiho, Makoto; Shimosaki, Yoshito; Shirakata, Masashi; Sueno, Tsuyoshi; Tokuchi, Akira; Torikai, Kota; Toyama, Takeshi; Wake, Masayoshi; Watanabe, Masao; Yamane, Isao

2005-01-01

A single bunch trapped in an RF bucket was accelerated by induction devices from 500 MeV to 8GeV beyond transition energy in the KEK-PS. This is the first demonstration of induction acceleration in a high energy circular ring. The acceleration was confirmed by measuring a temporal evolution of the RF phase through an entire acceleration.* Key devices in an induction acceleration system are an induction accelerating cavity capable of generating an induced voltage of 2kV/cell, a pulse modulator to drive the cavity (switching driver), and a DSP system to control gate signals for switching. Their remarkable characteristics are its repetition ratio of about 1MHz and duty factor of 50%. All devices have been newly developed at KEK so as to meet this requirement. The pulse modulator employing MOSFETs as switching elements is connected with the accelerating cavity through a long transmission cable in order to avoid a high-dose irradiation in the accelerator tunnel. The induction system has been running beyond more th...

Inductive energy storage commutator

International Nuclear Information System (INIS)

Gavrilov, I.M.

1987-01-01

An inductive energy storage commutator is described. The value of commutated current is up to 800 A, the voltage amplitude in the load is up to 50 kV, the working frequency is equal to 1-50 Hz, the commutated power is up to 40 MW. The commutating device comprises of the first stage commutator having two in-series connected modules of the BTSV - 800/235 high-voltage thyristor unit, the second stage commutator containing three GMI-43A parallel connected powerful pulsed triodes, a commutating capacitor, an induction coil, two supplementary high-voltage thyristor keys (20 in-series connected thyristors T2-300 (13 class)), load, control pulse shapers, thyristor keys, power supply

Switching Investigations on a SiC MOSFET in a TO-247 Package

DEFF Research Database (Denmark)

Anthon, Alexander; Hernandez Botella, Juan Carlos; Zhang, Zhe

2014-01-01

This paper deals with the switching behavior of a SiC MOSFET in a TO-247 package. Based on simulations, critical parasitic inductances in the circuit layout are analyzed and their effect on the switching losses highlighted. Especially the common source inductance, a critical parameter in a TO-247...... package, has a major influence on the switching energy. Crucial design guidelines for an improved double pulse test circuit are introduced which are used for practical investigations on the switching behavior. Switching energies of a SiC MOSFET in a TO-247 package is measured depending on varying gate...... resistance and loop inductances. With total switching energy of 340.24 μJ, the SiC MOSFET has more than six times lower switching losses than a regular Si IGBT. Implementing the SiC switches in a 3 kW T-Type inverter topology, efficiency improvements of 0.8 % are achieved and maximum efficiency of 97...

GPER1-mediated IGFBP-1 induction modulates IGF-1-dependent signaling in tamoxifen-treated breast cancer cells.

Science.gov (United States)

Vaziri-Gohar, Ali; Houston, Kevin D

2016-02-15

Tamoxifen, a selective estrogen receptor modulator, is a commonly prescribed adjuvant therapy for estrogen receptor-α (ERα)-positive breast cancer patients. To determine if extracellular factors contribute to the modulation of IGF-1 signaling after tamoxifen treatment, MCF-7 cells were treated with IGF-1 in conditioned medium (CM) obtained from 4-OHT-treated MCF-7 cells and the accumulation of phospho-Akt (S473) was measured. CM inhibited IGF-1-dependent cell signaling and suggesting the involvement of extracellular factors (ie. IGFBPs). A significant increase in IGFBP-1 mRNA and extracellular IGFBP-1 protein was observed in 4-OHT-treated MCF-7 cells. Knockdown experiments demonstrated that both GPER1 and CREB mediate IGFBP-1 induction. Furthermore, experiments showed that 4-OHT-dependent IGFBP-1 transcription is downstream of GPER1-activation in breast cancer cells. Additionally, neutralization and knockdown experiments demonstrated a role for IGFBP-1 in the observed inhibition of IGF-1 signaling. These results suggested that 4-OHT inhibits IGF-1 signaling via GPER1 and CREB mediated extracellular IGFBP-1 accumulation in breast cancer cells. Copyright © 2015 The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.

Effect of Inductive Coil Shape on Sensing Performance of Linear Displacement Sensor Using Thin Inductive Coil and Pattern Guide

Directory of Open Access Journals (Sweden)

Hiroyuki Wakiwaka

2011-11-01

Full Text Available This paper discusses the effect of inductive coil shape on the sensing performance of a linear displacement sensor. The linear displacement sensor consists of a thin type inductive coil with a thin pattern guide, thus being suitable for tiny space applications. The position can be detected by measuring the inductance of the inductive coil. At each position due to the change in inductive coil area facing the pattern guide the value of inductance is different. Therefore, the objective of this research is to study various inductive coil pattern shapes and to propose the pattern that can achieve good sensing performance. Various shapes of meander, triangular type meander, square and circle shape with different turn number of inductive coils are examined in this study. The inductance is measured with the sensor sensitivity and linearity as a performance evaluation parameter of the sensor. In conclusion, each inductive coil shape has its own advantages and disadvantages. For instance, the circle shape inductive coil produces high sensitivity with a low linearity response. Meanwhile, the square shape inductive coil has a medium sensitivity with higher linearity.

Multilevel Inverter by Cascading Industrial VSI

DEFF Research Database (Denmark)

Teodorescu, Remus; Blaabjerg, Frede; Pedersen, John Kim

2002-01-01

In this paper the modularity concept applied to medium-voltage adjustable speed drives is addressed. First, the single-phase cascaded voltage-source inverter that uses series connection of IGBT H-bridge modules with isolated dc-buses is presented. Next, a novel three-phase cascaded voltage......-source inverter that uses three IGBT triphase inverter modules along with an output transformer to obtain a 3 p.u. multilevel output voltage is introduced. The system yields in high-quality multistep voltage with up to 4 levels and low dv/dt, balanced operation of the inverter modules, each supplying a third...... of the motor rated kVA. The concept of using cascaded inverters is further extended to a new modular motor-modular inverter system where the motor winding connections are reconnected into several three-phase groups, either six-lead or 12-lead connection according to the voltage level, each powered...

Molecular density modulation type ultrahigh vacuum gauge

International Nuclear Information System (INIS)

Horikoshi, Gen-ichi; Komada, Kazutaka; Mizuno, Hajime

1978-01-01

When pressure is measured in ultrahigh vacuum region, with an ionization gauge one of the causes producing the measuring limit is its dark current due to so-called soft X-ray effect and ion desorption. A kind of the modulation gauge provided with a modulation electrode is described in this paper. If a plate is vibrating perpendicularly to its surface in the sufficiently low pressure gas to satisfy molecular conditions (molecular density n), the molecular density in the space in front of the plate is expected to vary with time, affected by the vibration of the plate. When the vacuum gauge is placed in this space, the modulated current is proportional to pressure P, which is not related to the current due to soft X-ray effect and ion desorption. The other cause of determining the pressure-measuring limit is noises, among which only the noise coherent with the vibration of the plate affects the measurement. To avoid the induced current by this type of noise, it is considered to use the pulse-counting technique using an electron multiplier. It is anticipated that the induced currents generated from electrical noises and mechanical vibrations can be avoided almost completely by this method. As a result, the theoretical measuring limit may be estimated at approximately 5 x 10 -13 Torr, if the mean residence time in the collision of molecules with the plate is assumed to be 1 sec, the sensitivity of the vacuum gauge S is 20 Torr -1 , electron current Ie is 2 x 10 -3 A and modulation coefficient m is 3 x 10 -3 . (Wakatsuki, Y.)

Voltage-regulating constant-current sources in a linear induction accelerator

International Nuclear Information System (INIS)

Zhao Juan; Cao Kefeng; Deng Jianjun; Zhu Lijun; Yang Jia; Ye Chao; Huang Bin; Cao Ningxiang; Dong Jinxuan; Zhang Jichang; Yu Zhiguo; Chen Min

2002-01-01

Constant-current Sources are one of key units in a linear induction accelerator. The requirements for the sources are to supply stable direct current of high power for the induction coil, be easy to computer-control and highly stable and reliable. Applying the technique of linear current source regulating in series, the primary voltage of the power transformer is regulated through an MJYS-JL-350A type three-phase alterative voltage-regulating module. The output current variation is 300-500 A when the load variation is 0.06-0.1 Ω and the voltage drop of the regulator tube is controlled within 8 V±2V when the variation of mains voltage is in ±10%. Both the current ripple and stability meet the technical requirements. The constant-current sources are controlled through an industrial controller. For each of the constant-current sources has a smallest system comprised of 8051 which is communication-controlled through a RS-485 interface, the sources can be controlled remotely

A current-pulsed power supply with rapid rising and falling edges for magnetic perturbation coils on the J-TEXT tokamak

International Nuclear Information System (INIS)

Yan, M.X.; Rao, B.; Ding, Y.H.; Hu, Q.M.; Hu, F.R.; Li, D.; Li, M.; Ji, X.K.; Xu, G.; Zheng, W.; Jiang, Z.H.

2017-01-01

Highlights: • The power supply is required to have rapid rising and falling edges. • A modified topology based on the buck chopper of current-pulsed power supply is presented and analyzed. • An entity meeting the electrical requirements has been constructed. • The spike voltage of IGBT is qualitatively analyzed. - Abstract: This study presents the design and principle of a current-pulsed power supply (CPPS) for the tearing mode (TM) feedback control of the J-TEXT tokamak. CPPS is a new method of stabilizing large magnetic islands and accelerating mode rotation through the use of modulated magnetic perturbation. In this application, continuous magnetic perturbation pulse trains with frequency of 1 kHz to kHz, amplitude of 0.25 G, and duty ratio of 20%–50% are required generating via in-vessel magnetic coils. A modified topology based on buck chopper is raised to satisfy the demands of inductive load. This modified topology is characterized by high frequency, rapid rising and falling edges, and large amplitude of current pulses. Appropriate RCD snubber circuit is applied to protect the Insulated Gate Bipolar Transistor (IGBT) switch device. Equipment with peak current that reaches 1 kA, frequency that ranges from 1 kHz to 3 kHz, and rising and falling time within 100 μs was constructed and applied to physical experiment.

A current-pulsed power supply with rapid rising and falling edges for magnetic perturbation coils on the J-TEXT tokamak

Energy Technology Data Exchange (ETDEWEB)

Yan, M.X. [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); College of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Rao, B., E-mail: borao@hust.edu.cn [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); College of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China); Ding, Y.H.; Hu, Q.M.; Hu, F.R.; Li, D.; Li, M.; Ji, X.K.; Xu, G.; Zheng, W.; Jiang, Z.H. [State Key Laboratory of Advanced Electromagnetic Engineering and Technology, Huazhong University of Science and Technology, Wuhan 430074 (China); College of Electrical and Electronic Engineering, Huazhong University of Science and Technology, Wuhan 430074 (China)

2017-02-15

Highlights: • The power supply is required to have rapid rising and falling edges. • A modified topology based on the buck chopper of current-pulsed power supply is presented and analyzed. • An entity meeting the electrical requirements has been constructed. • The spike voltage of IGBT is qualitatively analyzed. - Abstract: This study presents the design and principle of a current-pulsed power supply (CPPS) for the tearing mode (TM) feedback control of the J-TEXT tokamak. CPPS is a new method of stabilizing large magnetic islands and accelerating mode rotation through the use of modulated magnetic perturbation. In this application, continuous magnetic perturbation pulse trains with frequency of 1 kHz to kHz, amplitude of 0.25 G, and duty ratio of 20%–50% are required generating via in-vessel magnetic coils. A modified topology based on buck chopper is raised to satisfy the demands of inductive load. This modified topology is characterized by high frequency, rapid rising and falling edges, and large amplitude of current pulses. Appropriate RCD snubber circuit is applied to protect the Insulated Gate Bipolar Transistor (IGBT) switch device. Equipment with peak current that reaches 1 kA, frequency that ranges from 1 kHz to 3 kHz, and rising and falling time within 100 μs was constructed and applied to physical experiment.

Tvindkraft: Implementing a 500 kW 21-IGBT-Based Frequency Converter for a 1.7 MW Wind Power Conversion System

DEFF Research Database (Denmark)

Gonzalez, Pablo Casado; Pang, Ying; Reigosa, Paula Diaz

2013-01-01

The 54-meter-high Tvindkraft windmill was built by a group of volunteers during 1975-1978, as an argument for renewable energy sources as well as an argument against nuclear power. At that time it was the world’s biggest windmill. So far, Tvindkraft has been running for 35 years, proving...... that a wellconstructed wind turbine is a sustainable approach to renewable energy utilization. This paper deals with the analysis, simulation, implementation and experimental testing of a new 500 kW 21- IGBT-based frequency converter that will run in parallel with the former 12-Thyristor-based frequency converter...... to fully utilize the capacity of the windmill. Simulations and experimental results are presented side-by-side to verify the proper functionalities of the frequency converter described in this paper....

High Voltage EEE Parts for EMA/EHA Applications on Manned Launch Vehicles

Science.gov (United States)

Griffin, Trent; Young, David

2011-01-01

The objective of this paper is an assessment of high voltage electronic components required for high horsepower electric thrust vector control (TVC) systems for human spaceflight launch critical application. The scope consists of creating of a database of available Grade 1 electrical, electronic and electromechanical (EEE) parts suited to this application, a qualification path for potential non-Grade 1 EEE parts that could be used in these designs, and pathfinder testing to validate aspects of the proposed qualification plan. Advances in the state of the art in high power electric power systems enable high horsepower electric actuators, such as the electromechnical actuator (EMA) and the electro-hydrostatic actuator (EHA), to be used in launch vehicle TVC systems, dramaticly reducing weight, complexity and operating costs. Designs typically use high voltage insulated gate bipolar transistors (HV-IGBT). However, no Grade 1 HV-IGBT exists and it is unlikely that market factors alone will produce such high quality parts. Furthermore, the perception of risk, the lack of qualification methodoloy, the absence of manned space flight heritage and other barriers impede the adoption of commercial grade parts onto the critical path. The method of approach is to identify high voltage electronic component types and key parameters for parts currently used in high horsepower EMA/EHA applications, to search for higher quality substitutes and custom manufacturers, to create a database for these parts, and then to explore ways to qualify these parts for use in human spaceflight launch critical application, including grossly derating and possibly treating hybrid parts as modules. This effort is ongoing, but results thus far include identification of over 60 HV-IGBT from four manufacturers, including some with a high reliability process flow. Voltage ranges for HV-IGBT have been identified, as has screening tests used to characterize HV-IGBT. BSI BS ISO 21350 Space systems Off

Power cycling test and failure analysis of molded Intelligent Power IGBT Module under different temperature swing durations

DEFF Research Database (Denmark)

Choi, Uimin; Blaabjerg, Frede; Jørgensen, Søren

2016-01-01

on the lifetime of 600 V, 30 A, 3-phase molded Intelligent PowerModules (IPM) and their failuremechanismsare investigated. The study is based on the accelerated power cycling test results of 36 samples under 6 different conditions and tests are performed under realistic electrical conditions by an advanced power...

Efficiency improvements by Metal Wrap Through technology for n-type Si solar cells and modules

Energy Technology Data Exchange (ETDEWEB)

Wenchao, Zhao; Jianming, Wang; Yanlong, Shen; Ziqian, Wang; Yingle, Chen; Shuquan, Tian; Zhiliang, Wan; Bo, Yu; Gaofei, Li; Zhiyan, Hu; Jingfeng, Xiong [Yingli Green Energy Holding Co., Ltd, 3399 North Chaoyang Avenue, Baoding (China); Guillevin, N.; Heurtault, B.; Aken, B.B. van; Bennett, I.J.; Geerligs, L.J.; Weeber, A.W.; Bultman, J.H. [ECN Solar Energy, Petten (Netherlands)

2012-09-15

N-type Metal Wrap Through (n-MWT) is presented as an industrially promising back-contact technology to reach high performance of silicon solar cells and modules. It can combine benefits from both n-type base and MWT metallization. In this paper, the efficiency improvements of commercial industrial n-type bifacial Si solar cells (239 cm{sup 2}) and modules (60 cells) by the integration of the MWT technique are described. For the cell, after the optimization of integration, over 0.3% absolute efficiency gain was achieved over the similar non-MWT technology, and Voc gain and Isc gain up to 0.9% and 3.5%, respectively. These gains are mainly attributed to reduced shading loss and surface recombination. Besides the front pattern optimization, a 0.1m{Omega} reduction of Rs in via part will induce further 0.06% absolute efficiency improvement. For the module part, a power output of n-MWT module up to 279W was achieved, corresponding to a module efficiency of about 17.7%.

Converter structure-based power loss and static thermal modeling of the press-pack IGBT-based three-level ANPC and HB VSCs applied to Multi-MW wind turbines

DEFF Research Database (Denmark)

Senturk, Osman Selcuk; Munk-Nielsen, Stig; Teodorescu, Remus

2010-01-01

and the switch thermal performance which is determined by the converter load profile and the converter structure. In this study, the converter-structure based power loss and thermal models are developed for the medium voltage full-scale 3LANPC- VSC and 3L-HB-VSC utilizing press-pack IGBT-diode pairs......The wind turbine converters demand high power density due to nacelle space limitation and high reliability due to high maintenance cost. Once the converter topology with the semiconductor switch technology is selected, the converter power density and reliability are dependent on the component count...

A Versatile Vector for In Vivo Monitoring of Type I Interferon Induction and Signaling.

Directory of Open Access Journals (Sweden)

Estanislao Nistal-Villan

Full Text Available Development of reporter systems for in vivo examination of IFN-β induction or signaling of type I interferon (IFN-I pathways is of great interest in order to characterize biological responses to different inducers such as viral infections. Several reporter mice have been developed to monitor the induction of both pathways in response to different agonists. However, alternative strategies that do not require transgenic mice breeding have to date not been reported. In addition, detection of these pathways in vivo in animal species other than mice has not yet been addressed. Herein we describe a simple method based on the use of an adeno-associated viral vector (AAV8-3xIRF-ISRE-Luc containing an IFN-β induction and signaling-sensitive promoter sequence controlling the expression of the reporter gene luciferase. This vector is valid for monitoring IFN-I responses in vivo elicited by diverse stimuli in different organs. Intravenous administration of the vector in C57BL/6 mice and Syrian hamsters was able to detect activation of the IFN pathway in the liver upon systemic treatment with different pro-inflammatory agents and infection with Newcastle disease virus (NDV. In addition, intranasal instillation of AAV8-3xIRF-ISRE-Luc showed a rapid and transient IFN-I response in the respiratory tract of mice infected with the influenza A/PR8/34 virus lacking the NS1 protein. In comparison, this response was delayed and exacerbated in mice infected with influenza A/PR/8 wild type virus. In conclusion, the AAV8-3xIRF-ISRE-Luc vector offers the possibility of detecting IFN-I activation in response to different stimuli and in different animal models with no need for reporter transgenic animals.

Cyclobutane-type pyrimidine photodimer formation and induction of ornithine decarboxylase in human skin fibroblasts after UV irradiation

International Nuclear Information System (INIS)

Niggli, H.J.; Roethlisberger, R.

1988-01-01

Cyclobutane-type pyrimidine photodimers as well as the induction of ornithine decarboxylase (ODC) may serve as biochemical markers of the mutagenic and carcinogenic effects of ultraviolet light (UV). For this reason, it is important to compare the formation of pyrimidine dimers with the induction of ODC in human skin fibroblasts after irradiation with UVC (200-290 nm) and UVB (290-320 nm). In our studies we determined cytosine-thymine (C-T) as well as thymine-thymine dimer yields (T-T) by high-pressure liquid chromatography in cultures of neonatal normal human foreskin-derived fibroblasts after irradiation with UVC and UVB light. It was found that the yield of dimerization and the ratio of T-T/C-T decreased from the UVC to the UVB region. Time-course studies of ODC-induction in the same cells indicated that the maximal activity after UVB irradiation was retarded compared to UVC exposure. For the UV-induced ODC-levels, however, no significant difference in maximal induction could be measured after UVC and UVB irradiation at fluences where comparable yields of thymine dimerization are produced. Similar ODC-maxima were obtained with strains from children, while cells from adults showed significantly less pronounced ODC induction, indicating that ODC-response decreases with age and may therefore be used as a marker of aging

Reasoning about modular datatypes with Mendler induction

Directory of Open Access Journals (Sweden)

Paolo Torrini

2015-09-01

Full Text Available In functional programming, datatypes a la carte provide a convenient modular representation of recursive datatypes, based on their initial algebra semantics. Unfortunately it is highly challenging to implement this technique in proof assistants that are based on type theory, like Coq. The reason is that it involves type definitions, such as those of type-level fixpoint operators, that are not strictly positive. The known work-around of impredicative encodings is problematic, insofar as it impedes conventional inductive reasoning. Weak induction principles can be used instead, but they considerably complicate proofs. This paper proposes a novel and simpler technique to reason inductively about impredicative encodings, based on Mendler-style induction. This technique involves dispensing with dependent induction, ensuring that datatypes can be lifted to predicates and relying on relational formulations. A case study on proving subject reduction for structural operational semantics illustrates that the approach enables modular proofs, and that these proofs are essentially similar to conventional ones.

Relative Estimation of Water Content for Flat-Type Inductive-Based Oil Palm Fruit Maturity Sensor

Directory of Open Access Journals (Sweden)

Norhisam Misron

2016-12-01

Full Text Available The paper aims to study the sensor that identifies the maturity of oil palm fruit bunches by using a flat-type inductive concept based on a resonant frequency technique. Conventionally, a human grader is used to inspect the ripeness of the oil palm fresh fruit bunch (FFB which can be inconsistent and inaccurate. There are various new methods that are proposed with the intention to grade the ripeness of the oil palm FFB, but none has taken the inductive concept. In this study, the resonance frequency of the air coil is investigated. Samples of oil palm FFB are tested with frequencies ranging from 20 Hz to 10 MHz and the results obtained show a linear relationship between the graph of the resonance frequency (MHz against time (Weeks. It is observed that the resonance frequencies obtained for Week 10 (pre-mature and Week 18 (mature are around 8.5 MHz and 9.8 MHz, respectively. These results are compared with the percentage of the moisture content. Hence, the inductive method of the oil palm fruit maturity sensor can be used to detect the change in water content for ripeness detection of the oil palm FFB.

Borna disease virus nucleoprotein inhibits type I interferon induction through the interferon regulatory factor 7 pathway

International Nuclear Information System (INIS)

Song, Wuqi; Kao, Wenping; Zhai, Aixia; Qian, Jun; Li, Yujun; Zhang, Qingmeng; Zhao, Hong; Hu, Yunlong; Li, Hui; Zhang, Fengmin

2013-01-01

Highlights: •IRF7 nuclear localisation was inhibited by BDV persistently infected. •BDV N protein resistant to IFN induction both in BDV infected OL cell and N protein plasmid transfected OL cell. •BDV N protein is related to the inhibition of IRF7 nuclear localisation. -- Abstract: The expression of type I interferon (IFN) is one of the most potent innate defences against viral infection in higher vertebrates. Borna disease virus (BDV) establishes persistent, noncytolytic infections in animals and in cultured cells. Early studies have shown that the BDV phosphoprotein can inhibit the activation of type I IFN through the TBK1–IRF3 pathway. The function of the BDV nucleoprotein in the inhibition of IFN activity is not yet clear. In this study, we demonstrated IRF7 activation and increased IFN-α/β expression in a BDV-persistently infected human oligodendroglia cell line following RNA interference-mediated BDV nucleoprotein silencing. Furthermore, we showed that BDV nucleoprotein prevented the nuclear localisation of IRF7 and inhibited endogenous IFN induction by poly(I:C), coxsackie virus B3 and IFN-β. Our findings provide evidence for a previously undescribed mechanism by which the BDV nucleoprotein inhibits type I IFN expression by interfering with the IRF7 pathway

A Novel Approach for Eccentricity Fault Detection in Squirrel Cage Induction Motors

Directory of Open Access Journals (Sweden)

Mehdi Ahmadi

2013-01-01

Full Text Available In this paper, static eccentricity fault detection in induction motors is studied. Two dimensional finite element method (2D-FEM is used for faultless and eccentric condition modeling in induction motors. Also current and speed signals are compared in two experimental and simulation cases for model validating. For fault detection, fast Fourier transform is used at first. In this method, high order harmonics with small amplitude can alarms the fault occurrence. For this reason, the fault detection process is difficult.To overcome these drawbacks, it is suggested that two test coils contrive around the air-gap. So, any changes in air-gap can be detected easily. Moreover this test coils are used in open circuit case. So, these test coils do not effect on motor dynamics. Also, the results show that modulated voltage can be alarm the fault occurrence, type and percent well.

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4.

Science.gov (United States)

Andrade, Warrison A; Agarwal, Sarika; Mo, Shunyan; Shaffer, Scott A; Dillard, Joseph P; Schmidt, Tobias; Hornung, Veit; Fitzgerald, Katherine A; Kurt-Jones, Evelyn A; Golenbock, Douglas T

2016-06-14

The innate immune system is the first line of defense against Neisseria gonorrhoeae (GC). Exposure of cells to GC lipooligosaccharides induces a strong immune response, leading to type I interferon (IFN) production via TLR4/MD-2. In addition to living freely in the extracellular space, GC can invade the cytoplasm to evade detection and elimination. Double-stranded DNA introduced into the cytosol binds and activates the enzyme cyclic-GMP-AMP synthase (cGAS), which produces 2'3'-cGAMP and triggers STING/TBK-1/IRF3 activation, resulting in type I IFN expression. Here, we reveal a cytosolic response to GC DNA that also contributes to type I IFN induction. We demonstrate that complete IFN-β induction by live GC depends on both cGAS and TLR4. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS(-/-) and TLR4(-/-) cells. Collectively, these observations reveal cooperation between TLRs and cGAS in immunity to GC infection. Copyright © 2016. Published by Elsevier Inc.

Type I Interferon Induction by Neisseria gonorrhoeae: Dual Requirement of Cyclic GMP-AMP Synthase and Toll-like Receptor 4

Directory of Open Access Journals (Sweden)

Warrison A. Andrade

2016-06-01

Full Text Available The innate immune system is the first line of defense against Neisseria gonorrhoeae (GC. Exposure of cells to GC lipooligosaccharides induces a strong immune response, leading to type I interferon (IFN production via TLR4/MD-2. In addition to living freely in the extracellular space, GC can invade the cytoplasm to evade detection and elimination. Double-stranded DNA introduced into the cytosol binds and activates the enzyme cyclic-GMP-AMP synthase (cGAS, which produces 2′3′-cGAMP and triggers STING/TBK-1/IRF3 activation, resulting in type I IFN expression. Here, we reveal a cytosolic response to GC DNA that also contributes to type I IFN induction. We demonstrate that complete IFN-β induction by live GC depends on both cGAS and TLR4. Type I IFN is detrimental to the host, and dysregulation of iron homeostasis genes may explain lower bacteria survival in cGAS−/− and TLR4−/− cells. Collectively, these observations reveal cooperation between TLRs and cGAS in immunity to GC infection.

Discontinuity of mode transition and hysteresis in hydrogen inductively coupled plasma via a fluid model

International Nuclear Information System (INIS)

Xu Hui-Jing; Shu-Xia Zhao; Gao Fei; Zhang Yu-Ru; Li Xue-Chun; Wang You-Nian

2015-01-01

A new type of two-dimensional self-consistent fluid model that couples an equivalent circuit module is used to investigate the mode transition characteristics and hysteresis in hydrogen inductively coupled plasmas at different pressures, by varying the series capacitance of the matching box. The variations of the electron density, temperature, and the circuit electrical properties are presented. As cycling the matching capacitance, at high pressure both the discontinuity and hysteresis appear for the plasma parameters and the transferred impedances of both the inductive and capacitive discharge components, while at low pressure only the discontinuity is seen. The simulations predict that the sheath plays a determinative role on the presence of discontinuity and hysteresis at high pressure, by influencing the inductive coupling efficiency of applied power. Moreover, the values of the plasma transferred impedances at different pressures are compared, and the larger plasma inductance at low pressure due to less collision frequency, as analyzed, is the reason why the hysteresis is not seen at low pressure, even with a wider sheath. Besides, the behaviors of the coil voltage and current parameters during the mode transitions are investigated. They both increase (decrease) at the E to H (H to E) mode transition, indicating an improved (worsened) inductive power coupling efficiency. (paper)

Cyclooxygenase-2 induction in macrophages is modulated by docosahexaenoic acid via interactions with free fatty acid receptor 4 (FFA4).

Science.gov (United States)

Li, Xinzhi; Yu, Ying; Funk, Colin D

2013-12-01

Cyclooxygenase-2 (COX-2)-derived prostaglandins are implicated in numerous inflammatory disorders. The purpose of these studies was to examine previously unexplored interactions between COX-2 induction and docosahexaenoic acid (DHA) via the free fatty acid receptor 4 (FFA4) signaling pathway in murine RAW 264.7 cells and peritoneal macrophages challenged with lipopolysaccharide (LPS). DHA dose (IC50=18 μM)- and time-dependently reduced COX-2 expression, without affecting COX-1. DHA (25 μM for 24 h) decreased LPS-induced prostaglandin E2 (PGE2) synthesis by 81%, primarily through reducing COX-2 (60%), as well as down-regulating microsomal prostaglandin E synthase-1 (46%), but independently of peroxisome proliferator-activated receptors. FFA4 knockdown abrogated DHA effects on COX-2 induction, PGE2 production, and interleukin 6 (IL-6) gene expression. In the presence of inhibitors of eicosanoid metabolism via COX-2, 12/15-lipoxygenase and CYP450s (rofecoxib (1 μM), PD146176 (2 μM), or MS-PPOH (20 μM)), DHA was still effective in attenuating COX-2 induction. Moreover, Toll-like receptor 4 signaling via Akt/JNK phosphorylation and p65 nuclear translocation was repressed by DHA-activated FFA4 coupling with β-arrestin 2, which was reversed by FFA4 knockdown. These data support DHA modulation of COX-2 expression and activity, in part, via FFA4, which provides a new mechanistic explanation for some of the anti-inflammatory effects of DHA.

Long-range functional interactions of anterior insula and medial frontal cortex are differently modulated by visuospatial and inductive reasoning tasks.

Science.gov (United States)

Ebisch, Sjoerd J H; Mantini, Dante; Romanelli, Roberta; Tommasi, Marco; Perrucci, Mauro G; Romani, Gian Luca; Colom, Roberto; Saggino, Aristide

2013-09-01

The brain is organized into functionally specific networks as characterized by intrinsic functional relationships within discrete sets of brain regions. However, it is poorly understood whether such functional networks are dynamically organized according to specific task-states. The anterior insular cortex (aIC)-dorsal anterior cingulate cortex (dACC)/medial frontal cortex (mFC) network has been proposed to play a central role in human cognitive abilities. The present functional magnetic resonance imaging (fMRI) study aimed at testing whether functional interactions of the aIC-dACC/mFC network in terms of temporally correlated patterns of neural activity across brain regions are dynamically modulated by transitory, ongoing task demands. For this purpose, functional interactions of the aIC-dACC/mFC network are compared during two distinguishable fluid reasoning tasks, Visualization and Induction. The results show an increased functional coupling of bilateral aIC with visual cortices in the occipital lobe during the Visualization task, whereas coupling of mFC with right anterior frontal cortex was enhanced during the Induction task. These task-specific modulations of functional interactions likely reflect ability related neural processing. Furthermore, functional connectivity strength between right aIC and right dACC/mFC reliably predicts general task performance. The findings suggest that the analysis of long-range functional interactions may provide complementary information about brain-behavior relationships. On the basis of our results, it is proposed that the aIC-dACC/mFC network contributes to the integration of task-common and task-specific information based on its within-network as well as its between-network dynamic functional interactions. Copyright © 2013 Elsevier Inc. All rights reserved.

Induction by Coinduction and Control Operators in Call-by-Name

Directory of Open Access Journals (Sweden)

Yoshihiko Kakutani

2013-09-01

Full Text Available This paper studies emulation of induction by coinduction in a call-by-name language with control operators. Since it is known that call-by-name programming languages with control operators cannot have general initial algebras, interaction of induction and control operators is often restricted to effect-free functions. We show that some class of such restricted inductive types can be derived from full coinductive types by the power of control operators. As a typical example of our results, the type of natural numbers is represented by the type of streams. The underlying idea is a counterpart of the fact that some coinductive types can be expressed by inductive types in call-by-name pure language without side-effects.

Models for dose assessments. Modules for various biosphere types

Energy Technology Data Exchange (ETDEWEB)

Bergstroem, U.; Nordlinder, S.; Aggeryd, I. [Studsvik Eco and Safety AB, Nykoeping (Sweden)

1999-12-01

The main objective of this study was to provide a basis for illustrations of yearly dose rates to the most exposed individual from hypothetical leakages of radionuclides from a deep bedrock repository for spent nuclear fuel and other radioactive waste. The results of this study will be used in the safety assessment SR 97 and in a study on the design and long-term safety for a repository planned to contain long-lived low and intermediate level waste. The repositories will be designed to isolate the radionuclides for several hundred thousands of years. In the SR 97 study, however, hypothetical scenarios for leakage are postulated. Radionuclides are hence assumed to be transported in the geosphere by groundwater, and probably discharge into the biosphere. This may occur in several types of ecosystems. A number of categories of such ecosystems were identified, and turnover of radionuclides was modelled separately for each ecosystem. Previous studies had focused on generic models for wells, lakes and coastal areas. These models were, in this study, developed further to use site-specific data. In addition, flows of groundwater, containing radionuclides, to agricultural land and peat bogs were considered. All these categories are referred to as modules in this report. The forest ecosystems were not included, due to a general lack of knowledge of biospheric processes in connection with discharge of groundwater in forested areas. Examples of each type of module were run with the assumption of a continuous annual release into the biosphere of 1 Bq for each radionuclide during 10 000 years. The results are presented as ecosystem specific dose conversion factors (EDFs) for each nuclide at the year 10 000, assuming stationary ecosystems and prevailing living conditions and habits. All calculations were performed with uncertainty analyses included. Simplifications and assumptions in the modelling of biospheric processes are discussed. The use of modules may be seen as a step

Models for dose assessments. Modules for various biosphere types

International Nuclear Information System (INIS)

Bergstroem, U.; Nordlinder, S.; Aggeryd, I.

1999-12-01

The main objective of this study was to provide a basis for illustrations of yearly dose rates to the most exposed individual from hypothetical leakages of radionuclides from a deep bedrock repository for spent nuclear fuel and other radioactive waste. The results of this study will be used in the safety assessment SR 97 and in a study on the design and long-term safety for a repository planned to contain long-lived low and intermediate level waste. The repositories will be designed to isolate the radionuclides for several hundred thousands of years. In the SR 97 study, however, hypothetical scenarios for leakage are postulated. Radionuclides are hence assumed to be transported in the geosphere by groundwater, and probably discharge into the biosphere. This may occur in several types of ecosystems. A number of categories of such ecosystems were identified, and turnover of radionuclides was modelled separately for each ecosystem. Previous studies had focused on generic models for wells, lakes and coastal areas. These models were, in this study, developed further to use site-specific data. In addition, flows of groundwater, containing radionuclides, to agricultural land and peat bogs were considered. All these categories are referred to as modules in this report. The forest ecosystems were not included, due to a general lack of knowledge of biospheric processes in connection with discharge of groundwater in forested areas. Examples of each type of module were run with the assumption of a continuous annual release into the biosphere of 1 Bq for each radionuclide during 10 000 years. The results are presented as ecosystem specific dose conversion factors (EDFs) for each nuclide at the year 10 000, assuming stationary ecosystems and prevailing living conditions and habits. All calculations were performed with uncertainty analyses included. Simplifications and assumptions in the modelling of biospheric processes are discussed. The use of modules may be seen as a step

The Mechanism for Type I Interferon Induction by Mycobacterium tuberculosis is Bacterial Strain-Dependent.

Directory of Open Access Journals (Sweden)

Kirsten E Wiens

2016-08-01

Full Text Available Type I interferons (including IFNαβ are innate cytokines that may contribute to pathogenesis during Mycobacterium tuberculosis (Mtb infection. To induce IFNβ, Mtb must gain access to the host cytosol and trigger stimulator of interferon genes (STING signaling. A recently proposed model suggests that Mtb triggers STING signaling through bacterial DNA binding cyclic GMP-AMP synthase (cGAS in the cytosol. The aim of this study was to test the generalizability of this model using phylogenetically distinct strains of the Mtb complex (MTBC. We infected bone marrow derived macrophages with strains from MTBC Lineages 2, 4 and 6. We found that the Lineage 6 strain induced less IFNβ, and that the Lineage 2 strain induced more IFNβ, than the Lineage 4 strain. The strains did not differ in their access to the host cytosol and IFNβ induction by each strain required both STING and cGAS. We also found that the three strains shed similar amounts of bacterial DNA. Interestingly, we found that the Lineage 6 strain was associated with less mitochondrial stress and less mitochondrial DNA (mtDNA in the cytosol compared with the Lineage 4 strain. Treating macrophages with a mitochondria-specific antioxidant reduced cytosolic mtDNA and inhibited IFNβ induction by the Lineage 2 and 4 strains. We also found that the Lineage 2 strain did not induce more mitochondrial stress than the Lineage 4 strain, suggesting that additional pathways contribute to higher IFNβ induction. These results indicate that the mechanism for IFNβ by Mtb is more complex than the established model suggests. We show that mitochondrial dynamics and mtDNA contribute to IFNβ induction by Mtb. Moreover, we show that the contribution of mtDNA to the IFNβ response varies by MTBC strain and that additional mechanisms exist for Mtb to induce IFNβ.

Performance Evaluation of Eleven-Phase Induction Machine with Different PWM Techniques

Directory of Open Access Journals (Sweden)

M.I. Masoud

2015-06-01

Full Text Available Multiphase induction machines are used extensively in low and medium voltage (MV drives. In MV drives, power switches have a limitation associated with switching frequency. This paper is a comparative study of the eleven-phase induction machine’s performance when used as a prototype and fed sinusoidal pulse-width-modulation (SPWM with a low switching frequency, selective harmonic elimination (SHE, and single pulse modulation (SPM techniques. The comparison depends on voltage/frequency controls for the same phase of voltage applied on the machine terminals for all previous techniques. The comparative study covers torque ripple, stator and harmonic currents, and motor efficiency.

Packaging Solutions for Mitigating IGBT Short-Circuit Instabilities

DEFF Research Database (Denmark)

Reigosa, Paula Diaz; Iannuzzo, Francesco; Blaabjerg, Frede

2017-01-01

In this paper, the gate voltage oscillations occurring under short-circuit conditions in Insulated-Gate Bipolar Transistors are investigated, together with their dependency with respect to stray inductance variations. By using AnSYS Q3D Extractor, electromagnetic simulations are conducted to extr...

Induction of salt tolerance in Azolla microphylla Kaulf through modulation of antioxidant enzymes and ion transport.

Science.gov (United States)

Abraham, Gerard; Dhar, Dolly Wattal

2010-09-01

Azolla microphylla plants exposed directly to NaCl (13 dsm(-1)) did not survive the salinity treatment beyond a period of one day, whereas plants exposed directly to 4 and 9 dsm(-1) NaCl were able to grow and produce biomass. However, plants pre-exposed to NaCl (2 dsm(-1)) for 7 days on subsequent exposure to 13 dsm(-1) NaCl were able to grow and produce biomass although at a slow rate and are hereinafter designated as pre-exposed plants. The pre-exposed and directly exposed plants distinctly differed in their response to salt in terms of lipid peroxidation, proline accumulation, activity of antioxidant enzymes, such as SOD, APX, and CAT, and Na(+)/K(+) ratio. Efficient modulation of antioxidant enzymes coupled with regulation of ion transport play an important role in the induction of salt tolerance. Results show that it is possible to induce salt adaptation in A. microphylla by pre-exposing them to low concentrations of NaCl.

Modulation of type I immediate and type IV delayed immunoreactivity using direct suggestion and guided imagery during hypnosis.

Science.gov (United States)

Zachariae, R; Bjerring, P; Arendt-Nielsen, L

1989-11-01

Cutaneous reactivity against histamine skin prick test (Type I) and purified tuberculin protein derivative (Mantoux reaction, Type IV) was studied in eight volunteers under hypnosis. Types I and IV immunoreactivity were modulated by direct suggestion (Type I) and guided imagery (Type IV). The volunteers were highly susceptible subjects, selected by means of the Harvard Group Scale of Hypnotic Susceptibility, Form A. When the volunteers underwent hypnotic suggestion to decrease the cutaneous reaction to histamine prick test, a significant (P less than 0.02) reduction of the flare reaction (area of erythema) was observed compared with control histamine skin prick tests. The wheal reaction did not respond to hypnotic suggestion. Neither wheal nor flare reaction could be increased in size by hypnotic suggestion compared with control histamine skin prick tests. A hypnotic suggestion of increasing the Type IV reaction on one arm and decreasing the reaction on the other revealed a significant difference in both erythema size (P less than 0.02) and palpable induration (P less than 0.01). In two cases the reactions were monitored by laser doppler blood flowmetry and skin thickness measurement by ultrasound. The difference between the suggested increased and decreased reaction was 19% for the laser doppler bloodflow (in favor of the augmented side), and 44% for the dermal infiltrate thickness. This study objectively supports the numerous uncontrolled case reports of modulation of immunoreactivity in allergic diseases involving both Type I and Type IV skin reactions following hypnotic suggestions.

Filters on Co-Inductive streams: an application to Eratosthenes' sieve

OpenAIRE

Bertot , Yves

2004-01-01

We show how to model filter functions on the co-inductive types of infinite streams in type theory. These functions are partial but the theory imposes total functions. Our solution relies on describing a predicate characterizing the definition domain of filter functions, with a combination inductive and co-inductive aspects.

Fourier Multipliers on Decomposition Spaces of Modulation and Triebel–Lizorkin Type

DEFF Research Database (Denmark)

Cleanthous, G.; Georgiadis, Athanasios; Nielsen, Morten

2018-01-01

spaces in both the isotropic and an anisotropic setting. We derive a boundedness result for Fourier multipliers on anisotropic decomposition spaces of modulation and Triebel–Lizorkin type. As an application, we obtain equivalent quasi-norm characterizations for this class of decomposition spaces....

Characteristics of alpha/beta interferon induction after infection of murine fibroblasts with wild-type and mutant alphaviruses

International Nuclear Information System (INIS)

Burke, Crystal W.; Gardner, Christina L.; Steffan, Joshua J.; Ryman, Kate D.; Klimstra, William B.

2009-01-01

We examined the characteristics of interferon alpha/beta (IFN-α/β) induction after alphavirus or control Sendai virus (SeV) infection of murine fibroblasts (MEFs). As expected, SeV infection of wild-type (wt) MEFs resulted in strong dimerization of IRF3 and the production of high levels of IFN-α/β. In contrast, infection of MEFs with multiple alphaviruses failed to elicit detectable IFN-α/β. In more detailed studies, Sindbis virus (SINV) infection caused dimerization and nuclear migration of IRF3, but minimal IFN-β promoter activity, although surprisingly, the infected cells were competent for IFN production by other stimuli early after infection. A SINV mutant defective in host macromolecular synthesis shutoff induced IFN-α/β in the MEF cultures dependent upon the activities of the TBK1 IRF3 activating kinase and host pattern recognition receptors (PRRs) PKR and MDA5 but not RIG-I. These results suggest that wild-type alphaviruses antagonize IFN induction after IRF3 activation but also may avoid detection by host PRRs early after infection.

Regulation of the output power at the resonant converter

Energy Technology Data Exchange (ETDEWEB)

Stefanov, Goce G.; Sarac, Vasilija J. [University Goce Delecev-Stip, Faculty of Electrical Engineering, Radovis (Macedonia, The Former Yugoslav Republic of); Karadzinov, Ljupco V., E-mail: goce.stefanov@ugd.edu.mk [University Kiril and Methodyus-Skopje, FEIT Skopje(Macedonia, The Former Yugoslav Republic of)

2011-07-01

In this paper a method for regulating an alternating current voltage source with pair of IGBT transistor’s modules, in a full bridge configuration with series resonant converter is given. With the developed method a solution is obtained which can regulate the phase difference between output voltage and current through the inductor, in order to maintain maximum output power. Control electronic via feedback signals regulates the energy transfer to the tank by changing the pulse width of signals which are used as inputs to the gates of the IGBTs. By increasing or decreasing the pulse width transmitted to the various gates of the IGBT the energy transfer to the tank is increased or decreased . PowerSim simulations program is used for development of controlling methodology. Developed method is practically implemented in a prototype of the device for phase control of resonant converter with variable the resonant load. Key words: pulse width method, phase regulation , power converter.

Polyol pathway and modulation of ischemia-reperfusion injury in Type 2 diabetic BBZ rat hearts

Directory of Open Access Journals (Sweden)

Guberski Dennis

2008-10-01

Full Text Available Abstract We investigated the role of polyol pathway enzymes aldose reductase (AR and sorbitol dehydrogenase (SDH in mediating injury due to ischemia-reperfusion (IR in Type 2 diabetic BBZ rat hearts. Specifically, we investigated, (a changes in glucose flux via cardiac AR and SDH as a function of diabetes duration, (b ischemic injury and function after IR, (c the effect of inhibition of AR or SDH on ischemic injury and function. Hearts isolated from BBZ rats, after 12 weeks or 48 weeks diabetes duration, and their non-diabetic littermates, were subjected to IR protocol. Myocardial function, substrate flux via AR and SDH, and tissue lactate:pyruvate (L/P ratio (a measure of cytosolic NADH/NAD+, and lactate dehydrogenase (LDH release (a marker of IR injury were measured. Zopolrestat, and CP-470,711 were used to inhibit AR and SDH, respectively. Myocardial sorbitol and fructose content, and associated changes in L/P ratios were significantly higher in BBZ rats compared to non-diabetics, and increased with disease duration. Induction of IR resulted in increased ischemic injury, reduced ATP levels, increases in L/P ratio, and poor cardiac function in BBZ rat hearts, while inhibition of AR or SDH attenuated these changes and protected hearts from IR injury. These data indicate that AR and SDH are key modulators of myocardial IR injury in BBZ rat hearts and that inhibition of polyol pathway could in principle be used as a therapeutic adjunct for protection of ischemic myocardium in Type 2 diabetic patients.

How similar are recognition memory and inductive reasoning?

Science.gov (United States)

Hayes, Brett K; Heit, Evan

2013-07-01

Conventionally, memory and reasoning are seen as different types of cognitive activities driven by different processes. In two experiments, we challenged this view by examining the relationship between recognition memory and inductive reasoning involving multiple forms of similarity. A common study set (members of a conjunctive category) was followed by a test set containing old and new category members, as well as items that matched the study set on only one dimension. The study and test sets were presented under recognition or induction instructions. In Experiments 1 and 2, the inductive property being generalized was varied in order to direct attention to different dimensions of similarity. When there was no time pressure on decisions, patterns of positive responding were strongly affected by property type, indicating that different types of similarity were driving recognition and induction. By comparison, speeded judgments showed weaker property effects and could be explained by generalization based on overall similarity. An exemplar model, GEN-EX (GENeralization from EXamples), could account for both the induction and recognition data. These findings show that induction and recognition share core component processes, even when the tasks involve flexible forms of similarity.

Efficient modulation of γ-aminobutyric acid type A receptors by piperine derivatives.

Science.gov (United States)

Schöffmann, Angela; Wimmer, Laurin; Goldmann, Daria; Khom, Sophia; Hintersteiner, Juliane; Baburin, Igor; Schwarz, Thomas; Hintersteininger, Michael; Pakfeifer, Peter; Oufir, Mouhssin; Hamburger, Matthias; Erker, Thomas; Ecker, Gerhard F; Mihovilovic, Marko D; Hering, Steffen

2014-07-10

Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates γ-aminobutyric acid type A receptors (GABAAR). We have synthesized a library of 76 piperine analogues and analyzed their effects on GABAAR by means of a two-microelectrode voltage-clamp technique. GABAAR were expressed in Xenopus laevis oocytes. Structure-activity relationships (SARs) were established to identify structural elements essential for efficiency and potency. Efficiency of piperine derivatives was significantly increased by exchanging the piperidine moiety with either N,N-dipropyl, N,N-diisopropyl, N,N-dibutyl, p-methylpiperidine, or N,N-bis(trifluoroethyl) groups. Potency was enhanced by replacing the piperidine moiety by N,N-dibutyl, N,N-diisobutyl, or N,N-bistrifluoroethyl groups. Linker modifications did not substantially enhance the effect on GABAAR. Compound 23 [(2E,4E)-5-(1,3-benzodioxol-5-yl)-N,N-dipropyl-2,4-pentadienamide] induced the strongest modulation of GABAA (maximal GABA-induced chloride current modulation (IGABA-max = 1673% ± 146%, EC50 = 51.7 ± 9.5 μM), while 25 [(2E,4E)-5-(1,3-benzodioxol-5-yl)-N,N-dibutyl-2,4-pentadienamide] displayed the highest potency (EC50 = 13.8 ± 1.8 μM, IGABA-max = 760% ± 47%). Compound 23 induced significantly stronger anxiolysis in mice than piperine and thus may serve as a starting point for developing novel GABAAR modulators.

Progress in N-type Si Solar Cell and Module Technology for High Efficiency and Low Cost

Energy Technology Data Exchange (ETDEWEB)

Song, Dengyuan; Xiong, Jingfeng; Hu, Zhiyan; Li, Gaofei; Wang, Hongfang; An, Haijiao; Yu, Bo; Grenko, Brian; Borden, Kevin; Sauer, Kenneth; Cui, Jianhua; Wang, Haitao [Yingli Green Energy Holding Co., LTD, 071051 Boading (China); Roessler, T. [Yingli Green Energy Europe GmbH, Heimeranstr. 37, 80339 Munich (Germany); Bultman, J. [ECN Solar Energy, P.O. Box 1, NL-1755 ZG Petten (Netherlands); Vlooswijk, A.H.G.; Venema, P.R. [Tempress Systems BV, Radeweg 31, 8171 Vaassen (Netherlands)

2012-06-15

A novel high efficiency solar cell and module technology, named PANDA, using crystalline n-type CZ Si wafers has moved into large-scale production at Yingli. The first commercial sales of the PANDA modules commenced in mid 2010. Up to 600MW of mass production capacity from crystal-Si growth, wafer slicing, cell processing and module assembly have been implemented by the end of 2011. The PANDA technology was developed specifically for high efficiency and low cost. In contrast to the existing n-type Si solar cell manufacturing methods in mass production, this new technology is largely compatible with a traditional p-type Si solar cell production line by conventional diffusion, SiNx coating and screen-printing technology. With optimizing all technologies, Yingli's PANDA solar cells on semi-square 6-inch n-type CZ wafers (cell size 239cm{sup 2}) have been improved to currently have an average efficiency on commercial production lines exceeding 19.0% and up to 20.0% in pilot production. The PANDA modules have been produced and were certified according to UL1703, IEC 61215 and IEC 61730 standards. Nearly two years of full production on scale-up lines show that the PANDA modules have a high efficiency and power density, superior high temperature performance, near zero initial light induced degradation, and excellent efficiency at low irradiance.

Two-component vector solitons in defocusing Kerr-type media with spatially modulated nonlinearity

Energy Technology Data Exchange (ETDEWEB)

Zhong, Wei-Ping, E-mail: zhongwp6@126.com [Department of Electronic and Information Engineering, Shunde Polytechnic, Guangdong Province, Shunde 528300 (China); Texas A and M University at Qatar, P.O. Box 23874 Doha (Qatar); Belić, Milivoj [Texas A and M University at Qatar, P.O. Box 23874 Doha (Qatar); Institute of Physics, University of Belgrade, P.O. Box 57, 11001 Belgrade (Serbia)

2014-12-15

We present a class of exact solutions to the coupled (2+1)-dimensional nonlinear Schrödinger equation with spatially modulated nonlinearity and a special external potential, which describe the evolution of two-component vector solitons in defocusing Kerr-type media. We find a robust soliton solution, constructed with the help of Whittaker functions. For specific choices of the topological charge, the radial mode number and the modulation depth, the solitons may exist in various forms, such as the half-moon, necklace-ring, and sawtooth vortex-ring patterns. Our results show that the profile of such solitons can be effectively controlled by the topological charge, the radial mode number, and the modulation depth. - Highlights: • Two-component vector soliton clusters in defocusing Kerr-type media are reported. • These soliton clusters are constructed with the help of Whittaker functions. • The half-moon, necklace-ring and vortex-ring patterns are found. • The profile of these solitons can be effectively controlled by three soliton parameters.

Pharmacological benefits of selective modulation of cannabinoid receptor type 2 (CB2) in experimental Alzheimer's disease.

Science.gov (United States)

Jayant, Shalini; Sharma, Brij Mohan; Bansal, Rani; Sharma, Bhupesh

2016-01-01

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that pervasively affects the population across the world. Currently, there is no effective treatment available for this and existing drugs merely slow the progression of cognitive function decline. Thus, massive effort is required to find an intended therapeutic target to overcome this condition. The present study has been framed to investigate the ameliorative role of selective modulator of cannabinoid receptor type 2 (CB2), 1-phenylisatin in experimental AD condition. We have induced experimental AD in mice by using two induction models viz., intracerebroventricular (i.c.v.) administration of streptozotocin (STZ) and aluminum trichloride (AlCl3)+d-galactose. Morris water maze (MWM) and attentional set shifting test (ASST) were used to assess learning and memory. Hematoxylin-eosin and Congo red staining were used to examine the structural variation in brain. Brain oxidative stress (thiobarbituric acid reactive substance and glutathione), nitric oxide levels (nitrites/nitrates), acetyl cholinesterase activity, myeloperoxidase and calcium levels were also estimated. i.c.v. STZ as well as AlCl3+d-galactose have impaired spatial and reversal learning with executive functioning, increased brain oxidative and nitrosative stress, cholinergic activity, inflammation and calcium levels. Furthermore, these agents have also enhanced the burden of Aβ plaque in the brain. Treatment with 1-phenylisatin and donepezil attenuated i.c.v. STZ as well as AlCl3+d-galactose induced impairment of learning-memory, brain biochemistry and brain damage. Hence, this study concludes that CB2 receptor modulation can be a potential therapeutic target for the management of AD. Copyright © 2015 Elsevier Inc. All rights reserved.

Treatment of radioactive liquid waste by tubular type reverse osmosis module

International Nuclear Information System (INIS)

Nishimaki, Kenzo; Koyama, Akio; Tsutsui, Tenson; Mori, Koji.

1988-01-01

The applicability of reverse osmosis to radioactive liquid waste treatment was studied using a tubular type module. When four modules were used in a series, circulating volume of concentrate was much greater than permeate volume, therefore solute concentration and circulating rate of concentrate can be assumed uniform in the axial direction of the modules. DFs of stable elements contained in the tap water were 36-40 for Na, 50-55 for K, 170-250 for Mg and 90-160 for Ca. When Na concentration increased about ten times, DFs for all elements slightly decreased. For actual liquid waste tagged with radionuclides, DFs were in the range of 35-40 for 134 Cs, 150-200 for 85 Sr, and 180-280 for 58 Co. These DF values indicate the possibility of the treatment of low radioactive liquid waste by reverse osmosis. (author)

Type I interferon induction is detrimental during infection with the Whipple's disease bacterium, Tropheryma whipplei.

Directory of Open Access Journals (Sweden)

Khatoun Al Moussawi

2010-01-01

Full Text Available Macrophages are the first line of defense against pathogens. Upon infection macrophages usually produce high levels of proinflammatory mediators. However, macrophages can undergo an alternate polarization leading to a permissive state. In assessing global macrophage responses to the bacterial agent of Whipple's disease, Tropheryma whipplei, we found that T. whipplei induced M2 macrophage polarization which was compatible with bacterial replication. Surprisingly, this M2 polarization of infected macrophages was associated with apoptosis induction and a functional type I interferon (IFN response, through IRF3 activation and STAT1 phosphorylation. Using macrophages from mice deficient for the type I IFN receptor, we found that this type I IFN response was required for T. whipplei-induced macrophage apoptosis in a JNK-dependent manner and was associated with the intracellular replication of T. whipplei independently of JNK. This study underscores the role of macrophage polarization in host responses and highlights the detrimental role of type I IFN during T. whipplei infection.

Application of kinetic inductance thermometers to x-ray calorimetry

International Nuclear Information System (INIS)

Wai, Y.C.; Labov, S.E.; Silver, E.H.

1990-01-01

A kinetic inductance thermometer is applied to x-ray calorimetry, and its operation over a wide range of frequencies and geometries is discussed. Three amplifier configurations are described, one using a superconducting quantum interference device (SQUID) amplifier, another incorporating an FET amplifier in an amplitude modulated system, and the third, using a tunnel diode frequency modulated oscillator circuit. The predicted performance of each configuration is presented. 13 refs., 6 figs., 1 tab

Differential involvement of left prefrontal cortex in inductive and deductive reasoning.

Science.gov (United States)

Goel, Vinod; Dolan, Raymond J

2004-10-01

While inductive and deductive reasoning are considered distinct logical and psychological processes, little is known about their respective neural basis. To address this issue we scanned 16 subjects with fMRI, using an event-related design, while they engaged in inductive and deductive reasoning tasks. Both types of reasoning were characterized by activation of left lateral prefrontal and bilateral dorsal frontal, parietal, and occipital cortices. Neural responses unique to each type of reasoning determined from the Reasoning Type (deduction and induction) by Task (reasoning and baseline) interaction indicated greater involvement of left inferior frontal gyrus (BA 44) in deduction than induction, while left dorsolateral (BA 8/9) prefrontal gyrus showed greater activity during induction than deduction. This pattern suggests a dissociation within prefrontal cortex for deductive and inductive reasoning.

Online Chip Temperature Monitoring Using υce-Load Current and IR Thermography

DEFF Research Database (Denmark)

Ghimire, Pramod; Pedersen, Kristian Bonderup; Trintis, Ionut

2015-01-01

This paper presents on-state collector-emitter voltage (υce, on)-load current (Ic) method to monitor chip temperature on power insulated gate bipolar transistor (IGBT) modules in converter operation. The measurement method is also evaluated using infrared (IR) thermography. Temperature dependencies...

Study of Diffusion Barrier for Solder/ n-Type Bi2Te3 and Bonding Strength for p- and n-Type Thermoelectric Modules

Science.gov (United States)

Lin, Wen-Chih; Li, Ying-Sih; Wu, Albert T.

2018-01-01

This paper investigates the interfacial reaction between Sn and Sn3Ag0.5Cu (SAC305) solder on n-type Bi2Te3 thermoelectric material. An electroless Ni-P layer successfully suppressed the formation of porous SnTe intermetallic compound at the interface. The formation of the layers between Bi2Te3 and Ni-P indicates that Te is the dominant diffusing species. Shear tests were conducted on both Sn and SAC305 solder on n- and p-type Bi2Te3 with and without a Ni-P barrier layer. Without a Ni-P layer, porous SnTe would result in a more brittle fracture. A comparison of joint strength for n- and p-type thermoelectric modules is evaluated by the shear test. Adding a diffusion barrier increases the mechanical strength by 19.4% in n-type and 74.0% in p-type thermoelectric modules.

Force Factor Modulation in Electro Dynamic Loudspeakers

DEFF Research Database (Denmark)

Risbo, Lars; Agerkvist, Finn T.; Tinggaard, Carsten

2016-01-01

The relationship between the non-linear phenomenon of ’reluctance force’ and the position dependency of the voice coil inductance was established in 1949 by Cunningham, who called it ’magnetic attraction force’. This paper revisits Cunningham’s analysis and expands it into a generalised form...... that includes the frequency dependency and applies to coils with non-inductive (lossy) blocked impedance. The paper also demonstrates that Cunningham’s force can be explained physically as a modulation of the force factor which again is directly linked to modulation of the flux of the coil. A verification based...... on both experiments and simulations is presented along discussions of the impact of force factor modulation for various motor topologies. Finally, it is shown that the popular L2R2 coil impedance model does not correctly predict the force unless the new analysis is applied....

Investigations on 3-dimensional temperature distribution in a FLATCON-type CPV module

Science.gov (United States)

Wiesenfarth, Maike; Gamisch, Sebastian; Kraus, Harald; Bett, Andreas W.

2013-09-01

The thermal flow in a FLATCON®-type CPV module is investigated theoretically and experimentally. For the simulation a model in the computational fluid dynamics (CFD) software SolidWorks Flow Simulation was established. In order to verify the simulation results the calculated and measured temperatures were compared assuming the same operating conditions (wind speed and direction, direct normal irradiance (DNI) and ambient temperature). Therefore, an experimental module was manufactured and equipped with temperature sensors at defined positions. In addition, the temperature distribution on the back plate of the module was displayed by infrared images. The simulated absolute temperature and the distribution compare well with an average deviation of only 3.3 K to the sensor measurements. Finally, the validated model was used to investigate the influence of the back plate material on the temperature distribution by replacing the glass material by aluminum. The simulation showed that it is important to consider heat dissipation by radiation when designing a CPV module.

Research on Efficiency of Contactless Charging System based on Electromagnetic Induction

Directory of Open Access Journals (Sweden)

Chen Jianshu

2016-01-01

Full Text Available For the efficiency problem of contactless charging in type of electromagnetic induction, this paper establishes a mathematical model of contactless charging in type of electromagnetic induction and the theoretical derivation. This contactless charging simulation model is founded by Matlab/Simulink, which uses the frequency of PWM generator, the mutual inductance value of the coil and load resistance of RL to simulate some conditions, such as the working frequency in practical work, the distance of coil, whether the coils are directed at the central, and changing of loads. Then through the influence of the changing frequency, load and mutual inductance, contactless charging in type of electromagnetic induction is analyzed. By the whole simulation experiment on contactless charging, the theory deduced from the mathematical model is verified, and the method to improve inductive contactless charging is proved.

A Four-Level T-Type Neutral Point Piloted Inverter for Solar Energy Applications

Directory of Open Access Journals (Sweden)

Saddam Shueai Alnamer

2018-06-01

Full Text Available Multilevel inverters provide an output signal with low harmonic distortion and superior output voltages. This work proposes a new four-level T-type neutral point piloted (T-NPP topology with higher efficiency and low total harmonic distortion (THD and with the ability to withstand high voltage stresses, especially for high-power applications. The proposed topology is designed in such manner that the direct current (DC-voltage stresses split over the components with strong possibilities to increase the load current and switching frequency. However, the operation of the proposed topology is based on two essential principles. The first principle is that each upper and lower switch of each leg consists of two insulated gate bipolar transistors (IGBTs connected in series in order to withstand high voltage stresses and make it split over the two IGBTs in each switch. The second principle is using the DC-link circuit (T1 & T2 to generate 2Vdc and 1Vdc by connecting the bidirectional switches of each leg to the DC-link’s mid-point. Furthermore, the proposed four-level T-NPP inverter outperforms other converters by the high number of output voltage level, low number of components, simple structure and higher efficiency. Finally, the proposed T-NPP topology concept was validated via simulation, experiments and theoretical analysis.

Experimental and Numerical Study of the Radiant Induction-Unit and the Induction Radiant Air-Conditioning System

Directory of Open Access Journals (Sweden)

Qiang Si

2016-12-01

Full Text Available In this paper we proposed the novel air-conditioning system which combined induction ventilation and radiant air-conditioning. The indoor terminal device is the radiant induction-unit (RIDU. The RIDU is the induction unit combined with the pore radiant panel on which the copper pipes with rigid aluminum diffusion fins are installed. The two-stage evaporator chiller with the non-azeotropic mixture refrigerant is utilized in the system to reduce the initial investment in equipment. With the performance test and the steady state heat transfer model based on the theory of radiative heat transfer, the relationship between the induction ratio of the RIDU and the characteristic of the air supply was studied. Based on this, it is verified that the RIDU has a lower dew-point temperature and better anti-condensation performance than a traditional plate-type radiant panel. The characteristics of the radiation and convection heat transfer of the RIDU were studied. The total heat exchange of the RIDU can be 16.5% greater than that of the traditional plate-type radiant terminal.

Cost/performance analysis of an induction linac driver system for inertial fusion

International Nuclear Information System (INIS)

Hovingh, J.; Brady, V.O.; Faltens, A.; Hoyer, E.H.; Lee, E.P.

1986-01-01

A linear induction accelerator that produces a beam of energetic (≅ 10 GeV) heavy (A ≅ 200) ions is a prime candidate as a driver for inertial fusion. Continuing developments is amorphous iron for use in accelerating modules represent a potentially large reduction in the driver cost and an increase in the driver efficiency. Additional insulator developments may also represent a potentially large reduction in the driver cost. The efficiency and cost of the induction linac system is discussed as a function of output energy and pulse repetition frequency for several beam charge states, numbers of beams and beam particle species. Accelerating modules and transport modules are described. Large cost leverage items are identified as a guide to future research activities and technology of development that can yield further substantial reductions in the accelerator system cost and improvement in the accelerator system efficiency

Cost/performance analysis of an induction linac driver system for inertial fusion

International Nuclear Information System (INIS)

Hovingh, J.; Brady, V.O.; Faltens, A.; Hoyer, E.H.; Lee, E.P.

1985-11-01

A linear induction accelerator that produces a beam of energetic (approx. =10 GeV) heavy (CAapprox.200) ions is a prime candidate as a driver for inertial fusion. Continuing developments in amorphous iron for use in accelerating modules represent a potentially large reduction in the driver cost and an increase in the driver efficiency. Additional insulator developments may also represent a potentially large reduction in the driver cost. The efficiency and cost of the induction linac system is discussed as a function of output energy and pulse repetition frequency for several beam charge states, numbers of beams and beam particle species. Accelerating modules and transport modules will be described. Large cost leverage items will be identified as a guide to future research activities and technology of development that can yield further substantial reductions in the accelerator system cost and improvement in the accelerator system efficiency. 13 refs., 2 figs

Lexicographic Path Induction

DEFF Research Database (Denmark)

Schürmann, Carsten; Sarnat, Jeffrey

2009-01-01

Programming languages theory is full of problems that reduce to proving the consistency of a logic, such as the normalization of typed lambda-calculi, the decidability of equality in type theory, equivalence testing of traces in security, etc. Although the principle of transfinite induction......, and weak normalization for Gödel’s T follows indirectly; both have been formalized in a prototypical extension of Twelf....

Transplantation Tolerance Induction: Cell Therapies and their Mechanisms

Directory of Open Access Journals (Sweden)

Joseph R Scalea

2016-03-01

Full Text Available Cell based therapies have been studied extensively in the context of transplantation tolerance induction. The most successful protocols have relied on transfusion of bone marrow prior to the transplantation of a renal allograft. However, it is not clear that stem cells found in bone marrow are required in order to render a transplant candidate immunologically tolerant. Accordingly, mesenchymal stem cells, regulatory myeloid cells, T regulatory cells, and other cell types, are being tested as possible routes to tolerance induction, in the absence of donor derived stem cells. Early data with each of these cell types have been encouraging. However, the induction regimen capable of achieving consistent tolerance, whilst avoiding unwanted sided effects, and which is scalable to the human patient, has yet to be identified. Here we present the status of investigations of various tolerogenic cell types and the mechanistic rationale for their use in in tolerance induction protocols.

Comparative Study of Modulation-Based Individual Inverter Techniques for Direct and Inverse by using Star-Connection Induction Motor in Extra Low Voltage Application

Directory of Open Access Journals (Sweden)

Ardhia Wishnuprakasa

2016-12-01

Full Text Available In this study, the IEEE 519 Standard as a basis benchmarking for voltage (THDV and current (THDI in draft performance. Comparative Study based onthree-techniques of 2-Level Converter (2LC by using a Star-Connection Induction Motor (Y-CIM in ExtraLow Voltage (ELV Configuration.For the detail explanation, a primary inverter as Direct-Inverterby PWMdirect (PWM degreesand asecondary inverter as Inverse-Inverterby PWMinverse(PWM + PI degrees. It tends a modified algorithm,for eachof SPWM in six rules, and FHIPWM in 5th harmonics Injectedin standard modulation as the purpose for the Open-Ends of Pre-Dual Inverter in Decoupled SPWM for twelve rules, and Decoupled FHIPWM in combination of 5th harmonics Injectedin combination of two-standard-modulation. Those techniques are the purpose of two-inverter combination, which namelythe Equal Direct-Inverse (EDI algorithmproduct of prototyping in similarities. The observation is restricted in voltage scope between Simulation by using Power Simulator (PSIMand Application by using Microcontroller ARM STM32F4 Discovery.

A new multiplicity formula for the Weyl modules of type A

International Nuclear Information System (INIS)

Ye Jiachen; Zhou Zhongguo

2003-08-01

A monomial basis and a filtration of subalgebras for the universal enveloping algebra U(g) of a complex simple Lie algebra g l of type A I is given in this note. In particular, a new multiplicity formula for the Weyl module V(λ) of U(g l ) is obtained in this note. (author)

Different Solutions for the Generator-accelerator Module

Science.gov (United States)

Savin, E. A.; Matsievskiy, S. V.; Sobenin, N. P.; Zavadtsev, A. A.; Zavadtsev, D. A.

The most important part of the particle accelerators [1] - is the power generator together with the whole feeding system [2]. All types of generators, such as klystrons, magnetrons, solid state generators cover their own field of power and pulse length values. For the last couple of year the Inductive Output Tubes (IOT) becomes very popular because of their comparative construction simplicity: it represents the klystron output cavity with the grid modulated electron beam injected in it. Now such IOTs are used with the superconductive particle accelerators at 700 MHz operating frequency with around 1MW output power. Higher frequencies problem - is the inability to apply high frequency modulated voltage to the grid. Thus we need to figure out some kind of RF gun. But this article is about the first steps of the geometry and beam dynamics simulation in the six beam S-band IOT, which will be used with the compact biperiodic accelerating structure.

Priming, induction and modulation of plant defence responses by bacterial lipopolysaccharides

DEFF Research Database (Denmark)

Newman, Mari-Anne; Dow, J. Maxwell; Molinaro, Antonio

2007-01-01

Bacterial lipopolysaccharides (LPSs) have multiple roles in plant-microbe interactions. LPS contributes to the low permeability of the outer membrane, which acts as a barrier to protect bacteria from plant-derived antimicrobial substances. Conversely, perception of LPS by plant cells can lead...... to the triggering of defence responses or to the priming of the plant to respond more rapidly and/or to a greater degree to subsequent pathogen challenge. LPS from symbiotic bacteria can have quite different effects on plants to those of pathogens. Some details are emerging of the structures within LPS...... that are responsible for induction of these different plant responses. The lipid A moiety is not solely responsible for all of the effects of LPS in plants; core oligosaccharide and O-antigen components can elicit specific responses. Here, we review the effects of LPS in induction of defence-related responses...

High current induction linacs

International Nuclear Information System (INIS)

Barletta, W.; Faltens, A.; Henestroza, E.; Lee, E.

1994-07-01

Induction linacs are among the most powerful accelerators in existence. They have accelerated electron bunches of several kiloamperes, and are being investigated as drivers for heavy ion driven inertial confinement fusion (HIF), which requires peak beam currents of kiloamperes and average beam powers of some tens of megawatts. The requirement for waste transmutation with an 800 MeV proton or deuteron beam with an average current of 50 mA and an average power of 40 MW lies midway between the electron machines and the heavy ion machines in overall difficulty. Much of the technology and understanding of beam physics carries over from the previous machines to the new requirements. The induction linac allows use of a very large beam aperture, which may turn out to be crucial to reducing beam loss and machine activation from the beam halo. The major issues addressed here are transport of high intensity beams, availability of sources, efficiency of acceleration, and the state of the needed technology for the waste treatment application. Because of the transformer-like action of an induction core and the accompanying magnetizing current, induction linacs make the most economic sense and have the highest efficiencies with large beam currents. Based on present understanding of beam transport limits, induction core magnetizing current requirements, and pulse modulators, the efficiencies could be very high. The study of beam transport at high intensities has been the major activity of the HIF community. Beam transport and sources are limiting at low energies but are not significant constraints at the higher energies. As will be shown, the proton beams will be space-charge-dominated, for which the emittance has only a minor effect on the overall beam diameter but does determine the density falloff at the beam edge

IEEE Std 381-1977: IEEE standard criteria for type tests of Class 1E modules used in nuclear power generating stations

International Nuclear Information System (INIS)

Anon.

1992-01-01

This document describes the basic requirements of a type test program with the objective of verifying that a module used as Class 1E equipment in a nuclear power generating station meets or exceeds its design specifications. This document is limited to class 1E modules from and including the sensor through the logic circuitry of the final actuation devices. Except for those that are part of a module, switchgear, cables, connections, motors, valve actuators, station batteries, and penetrations are not included and are covered by other IEEE documents. The purpose of this document is to supplement the procedures and requirements given in IEEE Std 323-1974 [24] for type testing Class 1E modules, thereby providing directions for establishment of a type test program which will obtain the required test data and yield the required documentation of test methods and results. This standard is structured to present to the user the principal performance characteristics and environmental parameters which must be considered in designing a type test program for any give Class 1E module. These modules range from tiny sensors to complete racks or cabinets full of equipment that may be located inside or outside containment. The Class 1E modules are required to perform their function before, during, or after, or all, any design basis event specified for the module. The vast variety of modules covered by this document precludes the listing here of specific requirements for each type test

Physical interaction is not necessary for the induction of housing-type social buffering of conditioned hyperthermia in male rats.

Science.gov (United States)

Kiyokawa, Yasushi; Kodama, Yuka; Takeuchi, Yukari; Mori, Yuji

2013-11-01

In social animals, housing with conspecific animals after a stressful event attenuates the subsequent adverse outcomes due to the event, and this has been called housing-type social buffering. We have previously found that housing-type social buffering attenuates the enhancement of hyperthermia and Fos expression in the paraventricular nucleus of the hypothalamus that occurs in response to an aversive conditioned stimulus in male rats. Here, we analyzed the role of physical interactions during social housing in the induction of housing-type social buffering. When a fear-conditioned subject was alone after the conditioning and then exposed to the conditioned stimulus, it showed behavioral, autonomic, and neural stress responses. However, social housing, during which physical interactions were prevented by wire mesh, attenuated these autonomic and neural stress responses, as has been seen in previous studies. These results suggested that physical interaction was not necessary for the induction of housing-type social buffering. With this social cohabitation model, we then found that social cohabitation increased Fos expression in the posterior complex of the anterior olfactory nucleus of the fear-conditioned subject. Social cohabitation also increased Fos expression in 11 brain regions, including the prefrontal cortex, the nucleus accumbens, the bed nucleus of the stria terminalis, and the medial, lateral, basal, and cortical amygdala. These results provide information about the neural mechanisms that induce housing-type social buffering. Copyright © 2013 Elsevier B.V. All rights reserved.

Analysis of an induction linac driver system for inertial fusion

International Nuclear Information System (INIS)

Hovingh, J.; Brady, V.O.; Faltens, A.; Keefe, D.; Lee, E.P.

1987-07-01

A linear induction accelerator that produces a beam of energetic (5 to 20 GeV) heavy (130 to 210 amu) ions is a prime candidate as a driver for inertial fusion. Continuing developments in sources for ions with charge state greater than unity allow a potentially large reduction in the driver cost and an increase in the driver efficiency. The use of high undepressed tunes (σ 0 ≅ 85 0 ) and low depressed tunes (σ ≅ 8.5 0 ) also contributes to a potentially large reduction in the driver cost. The efficiency and cost of the induction linac system are discussed as a function of output energy and pulse repetition frequency for several ion masses and charge states. The cost optimization code LIACEP, including accelerating module alternatives, transport modules, and scaling laws, is presented. Items with large cost-leverage are identified as a guide to future research activities and development of technology that can yield substantial reductions in the accelerator system cost and improvement in the accelerator system efficiency. Finally, a cost-effective strategy using heavy ion induction linacs in a development scenario for inertial fusion is presented. 34 refs., 6 figs., 7 tabs

Low-induction pulse current generator with a volume bus arrangement

International Nuclear Information System (INIS)

Bocharov, Yu.N.; Krivosheev, S.I.; Lapin, N.G.; Shneerson, G.A.

1993-01-01

Pulse current generator (PC6) with 38 kj stored energy designed for up to 50 kV charging voltage used to obtain magnetic fields within megagauss range, is described. Space (volume) bus arrangement of its modules is used to reduce eigen inductance of PC6. Current is commutated by solid-body spark gaps. Under 3uH inductive load PC6 provides for formation of up to 2.25 MA current pulse with 3.3x10 12 A/s pulse rise time. Technique to determine low inductances as applied to PC6 elements is described. The described PC6 is used for experiments on generation of super-strong pulse magnetic fields in single-loop solenoid with volume occupied by magnetic field, 5-7 mm. Magnetic field with up to 350 T induction amplitude is obtained in these experiments

Induction chemotherapy with nedaplatin with 5-FU followed by intensity-modulated radiotherapy concurrent with chemotherapy for locoregionally advanced nasopharyngeal carcinoma

International Nuclear Information System (INIS)

Zheng Jijun; Wang Ge; Yang, G.Y.

2010-01-01

This Phase II study was conducted to evaluate the activity and feasibility of a regimen of nedaplatin and 5-fluorouracil as induction chemotherapy, followed by intensity-modulated radiotherapy concurrent with chemotherapy in patients with locoregionally advanced nasopharyngeal carcinoma. Patients received neoadjuvant chemotherapy comprised two cycles of 5-fluorouracil at 700 mg/m 2 /day administered on days 1-4 as continuous intravenous infusion and nedaplatin (100 mg/m 2 administered intravenous (i.v.) over 2 h) given after the administration of 5-fluorouracil on day 1, repeated every 3 weeks, followed by intensity-modulated radiotherapy concurrent with nedaplatin. During intensity-modulated radiotherapy, nedaplatin was administered at a dose of 100 mg/m 2 intravenous infusion on days 1, 22 and 43, given -60 min before radiation. Fifty-nine (95.8%) of the 60 patients were assessable for response. Thirty-eight cases of complete response and 14 cases of partial response were confirmed after completion of chemoradiation, with the objective response rate of 86.7% (95% confidence interval (CI), 78.1-95.3%). The median follow-up period was 48 months (range, 30-62 months). The 3-year progression-free survival and overall survival were 75.0% (95% CI, 63.0-87.0%) and 85.5% (95% CI, 75.9-95.1%). No patient showed Grade 3 or higher renal dysfunction. The most commonly observed late effect was xerostomia, but the severity diminished over time, and the detectable xerostomia at 24 months was 10.2%. There were no treatment-related deaths during this study. Neoadjuvant chemotherapy with nedaplatin and 5-fluorouracil followed by concomitant nedaplatin and intensity-modulated radiotherapy is an effective and safe treatment for Southern China patients affected by locoregionally advanced nasopharyngeal carcinoma. (author)

Resistin enhances the expansion of regulatory T cells through modulation of dendritic cells

Directory of Open Access Journals (Sweden)

Han Seung

2010-06-01

Full Text Available Abstract Background Resistin, a member of adipokine family, is known to be involved in the modulation of immune responses including inflammatory activity. Interestingly, resistin is secreted by adipocytes in mice and rats whereas it is secreted by leukocytes in humans. However, the mechanism behind the effect of resistin on the expansion of regulatory T cells (Tregs remains poorly understood. Therefore, we examined regulatory effect of resistin on the induction and cellular modification of Tregs. Results Both protein and mRNA expression of FoxP3, a representative marker of Tregs, increased in a dose-dependent manner when peripheral blood mononuclear cells were treated with resistin. At the same time, resistin had no direct effect on the induction of FoxP3 in CD4+ T cells, suggesting an indirect role through other cells type(s. Since DCs are an important player in the differentiation of T cells, we focused on the role of DCs in the modulation of Tregs by resistin. Resistin suppressed the expression of interferon regulatory factor (IRF-1 and its target cytokines, IL-6, IL-23p19 and IL-12p40, in DCs. Furthermore, FoxP3 expression is increased in CD4+ T cells when co-cultured with DCs and concomitantly treated with resistin. Conclusion Our results suggest that resistin induces expansion of functional Tregs only when co-cultured with DCs.

MMS induction of different types of genetic damage in Aspergillus nidulans: a comparative analysis in mutagenesis.

Science.gov (United States)

Gualandi, G; Bellincampi, D; Puppo, S

1979-09-01

Methyl methanesulphonate (MMS) was used to test the induction of gene mutation, somatic crossing-over and mitotic non-disjunction in A. nidulans. Gene mutation was tested by inducing mutants resistant to 8-azaguanine and revertants of methG1 in a haploid strain. Somatic crossing-over was tested in heterozygous diploids, both with a selective method, i.e. inducing homozygosis to FPA resistance in a heterozygous fpa A1/+ strain, and with a non-selective method, i.e. identifying the frequencies of colour sectors. This latter method was also used to estimate the induction of non-disjunction because additional markers were present which permitted us to distinguish the two types of colour segregant. Generally, 3 different experimental procedures were used, namely the "plate test", i.e. plating of conidia in agar media containing MMS, and two types of "liquid test", i.e. brief treatment of quiescent or pre-germinated conidia in MMS solution before they were plated on agar media. Point mutations were induced with about equal efficiency with each method, whereas crossing-over was induced preferentially when germinating conidia were exposed to MMS. On the other hand, non-disjunction was induced in germinating and quiescent spores with equal efficiency, but such segregants were not recovered with the selective (fpa) method. The results are discussed for both their practical use in the mutagenic testing procedure and their theoretical implication.

Tumor virus induction: a model for studying gene derepression by light radiation and chemicals

International Nuclear Information System (INIS)

Hellman, K.B.

1981-01-01

Cells of most, if not all, animal species contain information for type C retraviruses. This information is normally repressed, but may be derepressed after cellular exposure to a variety of agents. This phenomenon of virus induction can be utilized to investigate the phenomenon of gene derepression, since control of type C virus induction is thought to be under regulatory processes affecting cellular genes. Properties of type C retraviruses, results of virus induction studies, and discussion of a possible mechanism(s) for virus induction are presented in this review. Utilizing the Al-2 nonproducer cell line, originally derived from cells of the BALB/c mouse, quantitative and kinetic dose-response data have been obtained for type C virus induction by uv radiation, chemicals, and biological agents. Studies showing that protease inhibitors suppress induction suggest the presence of a common mechanism for controlling virus induction; i.e., a protein repressor(s) which acts to control virus gene derepression. Since protease inhibitors suppress induction of prophage in E. coli, similar processes may control virus induction in animal and bacterial systems

Type III radical hysterectomy after induction chemotherapy for patients with locally advanced cervical carcinoma.

Science.gov (United States)

Lopez-Graniel, C; Reyes, M; Chanona, G; Gonzalez, A; Robles, E; Mohar, A; Lopez-Basave, H; De La Garza, J G; Dueñas-Gonzalez, A

2001-01-01

Neoadjuvant chemotherapy followed by surgery is a promising approach in locally advanced cervical carcinoma. The aim of this study was to evaluate the feasibility, technical aspects, and clinical results of surgery after induction chemotherapy in this patient population. Forty-one untreated cervical carcinoma patients staged as IB2 to IIIB received three 21-day courses of cisplatin 100mg/m2 on day 1 and gemcitabine 1000 mg/m2 on days 1 and 8 followed by surgery or concomitant chemoradiation. The response to chemotherapy, operability, surgical/pathological findings, disease-free period, and survival of the surgically treated patients were evaluated. All 41 patients were evaluated for toxicity and 40 were evaluated for response. The overall objective response rate was 95% (95% confidence interval 88%-100%), and was complete in three patients (7.5%) and partial in 35 (87.5%). Granulocytopenia grades 3/4 occurred in 13.8% and 3.4% of the courses, respectively, whereas nonhematological toxicity was mild. Twenty-three patients underwent type III radical hysterectomy. Mean duration of surgery was 3.8 h (range 2:30-5:20), median estimated blood loss was 670 ml and median hospital stay was 5.2 days. Intraoperative complications occurred in one case (venous injury). In all but one case the resection margins were negative. Four patients (17%) had positive nodes (one node each); six (26%) had complete pathologic response, three (13%) had microscopic; and 14 (60%) macroscopic residual disease. At 24 months of maximum follow-up (median 20), the disease-free and overall survival rates were 59% and 91%, respectively. Induction chemotherapy with cisplatin/gemcitabine produced a high response rate and did not increase the difficulty of surgery. Operating time, blood loss, intraoperative complications, and hospital stay were all within the range observed for type III hysterectomy in early stage patients. We therefore conclude that type III radical hysterectomy is feasible in locally

High power switches for ion induction linacs

International Nuclear Information System (INIS)

Humphries, S. Jr.; Savage, M.; Saylor, W.B.

1985-01-01

The success of linear induction ion accelerators for accelerator inertial fusion (AIF) applications depends largely on innovations in pulsed power technology. There are tight constraints on the accuracy of accelerating voltage waveforms to maintain a low momentum spread. Furthermore, the non-relativistic ion beams may be subject to a klystron-like interaction with the accelerating cavities leading to enhanced momentum spread. In this paper, the author describe a novel high power switch with a demonstrated ability to interrupt 300 A at 20 kV in less than 60 ns. The switch may allow the replacement of pulse modulators in linear induction accelerators with hard tube pulsers. A power system based on a hard tube pulser could solve the longitudinal instability problem while maintaining high energy transfer efficiency. The problem of longitudinal beam control in ion induction linacs is reviewed in Section 2. Section 3 describes the principles of the plasma flow switch. Experimental results are summarized in Section 4

High power switches for ion induction linacs

International Nuclear Information System (INIS)

Humphries, S.; Savage, M.; Saylor, W.B.

1985-01-01

The success of linear induction ion accelerators for accelerator inertial fusion (AIF) applications depends largely on innovations in pulsed power technology. There are tight constraints on the accuracy of accelerating voltage waveforms to maintain a low momentum spread. Furthermore, the non-relativistic ion beams may be subject to a klystronlike interaction with the accelerating cavities, leading to enhanced momentum spread. In this paper, we describe a novel high power switch with a demonstrated ability to interrupt 300 A at 20 kV in less than 60 ns. The switch may allow the replacement of pulse modulators in linear induction accelerators with hard tube pulsers. A power system based on a hard tube pulser could solve the longitudinal instability problem while maintaining high energy transfer efficiency. The problem of longitudinal beam control in ion induction linacs is reviewed in Section 2. Section 3 describes the principles of the plasma flow switch. Experimental results are summarized in Section 4

Optimized control strategy for crowbarless solid state modular power supply

International Nuclear Information System (INIS)

Upadhyay, R.; Badapanda, M.K.; Tripathi, A.; Hannurkar, P.R.; Pithawa, C.K.

2009-01-01

Solid state modular power supply with series connected IGBT based power modules have been employed as high voltage bias power supply of klystron amplifier. Auxiliary compensation of full wave inverter bridge with ZVS/ZCS operations of all IGBTs over entire operating range is incorporated. An optimized control strategy has been adopted for this power supply needing no output filter, making this scheme crowbarless and is presented in this paper. DSP based fully digital control with same duty cycle for all power modules, have been incorporated for regulating this power supply along with adequate protection features. Input to this power supply is taken directly from 11 kV line and the input system is intentionally made 24 pulsed to reduce the input harmonics, improve the input power factor significantly, there by requiring no line filters. Various steps have been taken to increase the efficiency of major subsystems, so as to improve the overall efficiency of this power supply significantly. (author)

LHCb-VELO module production with n-side read-out on n- and p-type silicon substrates

International Nuclear Information System (INIS)

Affolder, A.; Bowcock, T.J.V.; Carrol, J.L.; Casse, G.; Huse, T.; Patel, G.D.; Rinnert, K.; Smith, N.A.; Turner, P.R.

2007-01-01

The modules for the Vertex Locator detector of the LHCb experiment represent a technical challenge for their complexity. The design of the sensors uses a complex double metal routing of the connection to the read-out strips and a high density of metal lines has to be accommodated in the module. The detectors are n-side read-out to be able to survive the highest radiation damage of any micro-strip sensor used in LHC experiments. The present choice is n-strips on n-type substrates (n-in-n geometry). Double-sided lithography is required, which impact on the cost of the devices and on the module construction. Moreover, the compact size of the hybrid imposes sophisticated technical solutions for cooling the electronics and the detector. The module construction and the possible benefits offered by the choice of p-type substrate detectors compared to the present n-in-n devices are here discussed in details

Pulse induction heating

Energy Technology Data Exchange (ETDEWEB)

Vasiliev, A S; Kachanov, B Y; Kogan, B V

1993-12-31

Induction heating and three types of pulse processes were studied. It was found that in pulse processes the frequency and pulse duration of heat treatments do not remain constant. High frequency pulse heat treatments can be used on sprayed coatings; such treatments will result in stronger surfaces with no cracks. For induction hardening, the rate of specific power was 1 to 1.5 kW/sq.cm, for forging it was 0.2 to 0.3 kW/sq.cm and for melting it was 0.05 to 0.1 kW/sq.cm. The application of pulse heating will result in higher rates of specific power.

Development of 700 pps high-duty-cycle line-type pulse modulator

Energy Technology Data Exchange (ETDEWEB)

Baba, H.; Satoh, K.; Miura, A. [NIHON KOSHUHA Co., LTD., Yokohama, Kanagawa (Japan)] [and others

1997-04-01

The high-duty-cycle line-type pulse modulator has been developed to drive the 5.5 MW S-band klystron at the 700 pps maximum repetition-rate and the 14 {mu}sec flat-top pulse-width. To keep an enough recovery time to the thyratron-tube, the command charging scheme was adopted. To do this, a charging SCR-bank has been developed, which is capable of handling the peak charging current of 50 A. The system achieved the world wide highest average output-power of 205 kW. Two modulators have been installed in a new high-duty-cycle electron linear accelerator, which has been started its business operation in March 1996 as an electron-beam-sterilization facility. (J.P.N)

L-Type Calcium Channels Modulation by Estradiol.

Science.gov (United States)

Vega-Vela, Nelson E; Osorio, Daniel; Avila-Rodriguez, Marco; Gonzalez, Janneth; García-Segura, Luis Miguel; Echeverria, Valentina; Barreto, George E

2017-09-01

Voltage-gated calcium channels are key regulators of brain function, and their dysfunction has been associated with multiple conditions and neurodegenerative diseases because they couple membrane depolarization to the influx of calcium-and other processes such as gene expression-in excitable cells. L-type calcium channels, one of the three major classes and probably the best characterized of the voltage-gated calcium channels, act as an essential calcium binding proteins with a significant biological relevance. It is well known that estradiol can activate rapidly brain signaling pathways and modulatory/regulatory proteins through non-genomic (or non-transcriptional) mechanisms, which lead to an increase of intracellular calcium that activate multiple kinases and signaling cascades, in the same way as L-type calcium channels responses. In this context, estrogens-L-type calcium channels signaling raises intracellular calcium levels and activates the same signaling cascades in the brain probably through estrogen receptor-independent modulatory mechanisms. In this review, we discuss the available literature on this area, which seems to suggest that estradiol exerts dual effects/modulation on these channels in a concentration-dependent manner (as a potentiator of these channels in pM concentrations and as an inhibitor in nM concentrations). Indeed, estradiol may orchestrate multiple neurotrophic responses, which open a new avenue for the development of novel estrogen-based therapies to alleviate different neuropathologies. We also highlight that it is essential to determine through computational and/or experimental approaches the interaction between estradiol and L-type calcium channels to assist these developments, which is an interesting area of research that deserves a closer look in future biomedical research.

Fuzzy Logic Temperature Control System For The Induction Furnace

Directory of Open Access Journals (Sweden)

Lei Lei Hnin

2015-08-01

Full Text Available This research paper describes the fuzzy logic temperature control system of the induction furnace. Temperature requirement of the heating system varies during the heating process. In the conventional control schemes the switching losses increase with the change in the load. A closed loop control is required to have a smooth control on the system. In this system pulse width modulation based power control scheme for the induction heating system is developed using the fuzzy logic controller. The induction furnace requires a good voltage regulation to have efficient response. The controller controls the temperature depending upon weight of meat water and time. This control system is implemented in hardware system using microcontroller. Here the fuzzy logic controller is designed and simulated in MATLAB to get the desire condition.

The response of early neural genes to FGF signaling or inhibition of BMP indicate the absence of a conserved neural induction module

Directory of Open Access Journals (Sweden)

Rogers Crystal D

2011-12-01

Full Text Available Abstract Background The molecular mechanism that initiates the formation of the vertebrate central nervous system has long been debated. Studies in Xenopus and mouse demonstrate that inhibition of BMP signaling is sufficient to induce neural tissue in explants or ES cells respectively, whereas studies in chick argue that instructive FGF signaling is also required for the expression of neural genes. Although additional signals may be involved in neural induction and patterning, here we focus on the roles of BMP inhibition and FGF8a. Results To address the question of necessity and sufficiency of BMP inhibition and FGF signaling, we compared the temporal expression of the five earliest genes expressed in the neuroectoderm and determined their requirements for induction at the onset of neural plate formation in Xenopus. Our results demonstrate that the onset and peak of expression of the genes vary and that they have different regulatory requirements and are therefore unlikely to share a conserved neural induction regulatory module. Even though all require inhibition of BMP for expression, some also require FGF signaling; expression of the early-onset pan-neural genes sox2 and foxd5α requires FGF signaling while other early genes, sox3, geminin and zicr1 are induced by BMP inhibition alone. Conclusions We demonstrate that BMP inhibition and FGF signaling induce neural genes independently of each other. Together our data indicate that although the spatiotemporal expression patterns of early neural genes are similar, the mechanisms involved in their expression are distinct and there are different signaling requirements for the expression of each gene.

Error-Free Text Typing Performance of an Inductive Intra-Oral Tongue Computer Interface for Severely Disabled Individuals.

Science.gov (United States)

Andreasen Struijk, Lotte N S; Bentsen, Bo; Gaihede, Michael; Lontis, Eugen R

2017-11-01

For severely paralyzed individuals, alternative computer interfaces are becoming increasingly essential for everyday life as social and vocational activities are facilitated by information technology and as the environment becomes more automatic and remotely controllable. Tongue computer interfaces have proven to be desirable by the users partly due to their high degree of aesthetic acceptability, but so far the mature systems have shown a relatively low error-free text typing efficiency. This paper evaluated the intra-oral inductive tongue computer interface (ITCI) in its intended use: Error-free text typing in a generally available text editing system, Word. Individuals with tetraplegia and able bodied individuals used the ITCI for typing using a MATLAB interface and for Word typing for 4 to 5 experimental days, and the results showed an average error-free text typing rate in Word of 11.6 correct characters/min across all participants and of 15.5 correct characters/min for participants familiar with tongue piercings. Improvements in typing rates between the sessions suggest that typing ratescan be improved further through long-term use of the ITCI.

Oxygen effect and influence of the anoxic radiosensitizing agent TAN on the induction of λ-prophage in polA and wild type E.coli strains after gamma irradiation

International Nuclear Information System (INIS)

Bonev, M.N.; Sivriev, I.K.; Kolev, S.D.

1998-01-01

The modification effect of both oxygen and radiosensitizing agent TAN on the λ-prophage induction in polA mutant and wild type E.coli cells after γ-irradiation was studied. The oxygen and TAN enhancement ratio concerning the cell sensitivity is more significant in polA mutant cells as compared to that in the wild type ones. The same behaviour has been observed for the oxygen and TAN enhancement ratio for the λ-prophage induction. The TAN effect on the survival and on the λ-induction was smaller than the oxygen effect. The bigger efficiency of oxygen and DNA-radicals are more difficult to repair than those created by an interaction of TAN and DNA-radicals

The RF power system for the SNS linac

International Nuclear Information System (INIS)

Tallerico, P.J.; Reass, W.A.

1998-01-01

The initial goal of the SNS project is to produce a 1 MW average beam of protons with short pulse lengths onto a neutron-producing target. The objective of the SNS RF system is to generate 117 MW peak of pulsed 805 MHz microwave power with an accelerated beam pulse length of 1.04 ms at a 60 Hz repetition rate. The power system must be upgradeable in peak power to deliver 2 MW average power to the neutron target. The RF system also requires about 3 MW peak of RF power at 402.5 MHz, but that system is not discussed here. The design challenge is to produce an RF system at minimum cost, that is very reliable and economical to operate. The combination of long pulses and high repetition rates make conventional solutions, such as the pulse transformer and transmission line method, very expensive. The klystron, with a modulating anode, and 1.5 MW of peak output power is the baseline RF amplifier, an 56 are required in the baseline design. The authors discuss four power system configurations that are the candidates for the design. The baseline design is a floating-deck modulating anode system. A second power system being investigated is the fast-pulsed power supply, that can be turned on and off with a rise time of under 0.1 ms. This could eliminate the need for a modulator, and drastically reduce the energy storage requirements. A third idea is to use a pulse transformer with a series IGBT switch and a bouncer circuit on the primary side, as was done for the TESLA modulator. A fourth method is to use a series IGBT switch at high voltage, and not use a pulse transformer. The authors discuss the advantages and problems of these four types of power systems, but they emphasize the first two

Long-pulse induction acceleration of heavy ions

International Nuclear Information System (INIS)

Faltens, A.; Firth, M.; Keefe, D.; Rosenblum, S.S.

1983-03-01

A long-pulse induction acceleration unit has been installed in the high-current Cs + beam line at LBL and has accelerated heavy ions. A maximum energy gain of 250 keV for 1.5 μs is possible. The unit comprises 12 independent modules which may be used to synthesize a variety of waveforms by varying the triggering times of the low-voltage trigger generators

Long-pulse induction acceleration of heavy ions

International Nuclear Information System (INIS)

Faltons, A.; Firth, M.; Keefe, D.; Rosenblum, S.

1983-01-01

A long-pulse induction acceleration unit has been installed in the high-current Cs + beam line at LBL and has accelerated heavy ions. A maximum energy gain of 250 keV for 1.5 μs is possible. The unit comprises 12 independent modules which may be used to synthesize a variety of waveforms by varying the triggering times of the low voltage trigger generators

Long-pulse induction acceleration of heavy-ions

International Nuclear Information System (INIS)

Faltens, A.; Firth, M.; Keefe, D.; Rosenblum, S.S.

1983-01-01

A long-pulse induction acceleration unit has been installed in the high-current Cs + beam line at LBL and has accelerated heavy ions. A maximum energy gain of 250 keV for 1.5 μs is possible. The unit comprises 12 independent modules which may be used to synthesize a variety of waveforms by varying the triggering times of the low voltage trigger generators

Stator Fault Modelling of Induction Motors

DEFF Research Database (Denmark)

Thomsen, Jesper Sandberg; Kallesøe, Carsten

2006-01-01

In this paper a model of an induction motor affected by stator faults is presented. Two different types of faults are considered, these are; disconnection of a supply phase, and inter-turn and turn-turn short circuits inside the stator. The output of the derived model is compared to real measurem......In this paper a model of an induction motor affected by stator faults is presented. Two different types of faults are considered, these are; disconnection of a supply phase, and inter-turn and turn-turn short circuits inside the stator. The output of the derived model is compared to real...... measurements from a specially designed induction motor. With this motor it is possible to simulate both terminal disconnections, inter-turn and turn-turn short circuits. The results show good agreement between the measurements and the simulated signals obtained from the model. In the tests focus...

Glycemic Variability Is Associated With Reduced Cardiac Autonomic Modulation in Women With Type 2 Diabetes

DEFF Research Database (Denmark)

Fleischer, Jesper; Lebech Cichosz, Simon; Hoeyem, Pernille

2015-01-01

OBJECTIVE: To investigate the sex differences in cardiac autonomic modulation in patients with newly diagnosed type 2 diabetes and to determine whether cardiac autonomic modulation is associated with glycemic variability. RESEARCH DESIGN AND METHODS: We investigated a cohort consisting of 48 men...... and 39 women with non-insulin-treated type 2 diabetes and a known duration of diabetes ... by the standard deviation of normal-to-normal intervals (P = 0.001), the root mean square of successive differences (P = 0.018), LF (P power (P = 0.008), RS ratio (P = 0.027), and expiration-to-inspiration ratio (P = 0.006) was significantly associated with increased glycemic...

An Inductive Link-Based Wireless Power Transfer System for Biomedical Applications

Directory of Open Access Journals (Sweden)

M. A. Adeeb

2012-01-01

Full Text Available A wireless power transfer system using an inductive link has been demonstrated for implantable sensor applications. The system is composed of two primary blocks: an inductive power transfer unit and a backward data communication unit. The inductive link performs two functions: coupling the required power from a wireless power supply system enabling battery-less, long-term implant operation and providing a backward data transmission path. The backward data communication unit transmits the data to an outside reader using FSK modulation scheme via the inductive link. To demonstrate the operation of the inductive link, a board-level design has been implemented with high link efficiency. Test results from a fabricated sensor system, composed of a hybrid implementation of custom-integrated circuits and board-level discrete components, are presented demonstrating power transmission of 125 mW with a 12.5% power link transmission efficiency. Simultaneous backward data communication involving a digital pulse rate of up to 10 kbps was also observed.

Vitrification of high level nuclear waste inside ambient temperature disposal containers using inductive heating: The SMILE system

International Nuclear Information System (INIS)

Powell, J.; Reich, M.; Barletta, R.

1996-01-01

A new approach, termed SMILE (Small Module Inductively Loaded Energy), for the vitrification of high level nuclear wastes (HLW) is described. Present vitrification systems liquefy the HLW solids and associated frit material in large high temperature melters. The molten mix is then poured into small (∼1 m 3 ) disposal canisters, where it solidifies and cools. SMILE eliminates the separate, large high temperature melter. Instead, the BLW solids and frit melt inside the final disposal containers, using inductive heating. The contents then solidify and cool in place. The SMILE modules and the inductive heating process are designed so that the outer stainless can of the module remains at near ambient temperature during the process cycle. Module dimensions are similar to those of present disposal containers. The can is thermally insulated from the high temperature inner container by a thin layer of refractory alumina firebricks. The inner container is a graphite crucible lined with a dense alumina refractory that holds the HLW and fiit materials. After the SMILE module is loaded with a slurry of HLW and frit solids, an external multi-turn coil is energized with 30-cycle AC current. The enclosing external coil is the primary of a power transformer, with the graphite crucible acting as a single turn ''secondary.'' The induced current in the ''secondary'' heats the graphite, which in turn heats the HLW and frit materials. The first stage of the heating process is carried out at an intermediate temperature to drive off remnant liquid water and water of hydration, which takes about 1 day. The small fill/vent tube to the module is then sealed off and the interior temperature raised to the vitrification range, i.e., ∼1200C. Liquefaction is complete after approximately 1 day. The inductive heating then ceases and the module slowly loses heat to the environment, allowing the molten material to solidify and cool down to ambient temperature

Antigenic modulation limits the effector cell mechanisms employed by type I anti-CD20 monoclonal antibodies.

Science.gov (United States)

Tipton, Thomas R W; Roghanian, Ali; Oldham, Robert J; Carter, Matthew J; Cox, Kerry L; Mockridge, C Ian; French, Ruth R; Dahal, Lekh N; Duriez, Patrick J; Hargreaves, Philip G; Cragg, Mark S; Beers, Stephen A

2015-03-19

Following the success of rituximab, 2 other anti-CD20 monoclonal antibodies (mAbs), ofatumumab and obinutuzumab, have entered clinical use. Ofatumumab has enhanced capacity for complement-dependent cytotoxicity, whereas obinutuzumab, a type II mAb, lacks the ability to redistribute into lipid rafts and is glycoengineered for augmented antibody-dependent cellular cytotoxicity (ADCC). We previously showed that type I mAbs such as rituximab have a propensity to undergo enhanced antigenic modulation compared with type II. Here we assessed the key effector mechanisms affected, comparing type I and II antibodies of various isotypes in ADCC and antibody-dependent cellular-phagocytosis (ADCP) assays. Rituximab and ofatumumab depleted both normal and leukemic human CD20-expressing B cells in the mouse less effectively than glycoengineered and wild-type forms of obinutuzumab, particularly when human immunoglobulin G1 (hIgG1) mAbs were compared. In contrast to mouse IgG2a, hIgG1 mAbs were ineffective in ADCC assays with murine natural killer cells as effectors, whereas ADCP was equivalent for mouse IgG2a and hIgG1. However, rituximab's ability to elicit both ADCC and ADCP was reduced by antigenic modulation, whereas type II antibodies remained unaffected. These data demonstrate that ADCP and ADCC are impaired by antigenic modulation and that ADCP is the main effector function employed in vivo. © 2015 by The American Society of Hematology.

Lysogenic induction in Lex Al Escherichia coli mutants: characterization of the induction and prophage repressor influence

International Nuclear Information System (INIS)

Carvalho, R.E.S.

1982-01-01

SOS functions require new synthesis of protein and have been described as dependent on both the rec A and lex A genes. The induction of prophage was studied in bacterial strains lysogenic for a series of phages which synthesize different levels of repressor (λ, λ i m m 4 3 4 J and λ i m m 4 3 4 T ) and was compared to W-reactivation. Prophage induction was detected in lex Al mutants although at a slightly lower level and requiring two times longer when compared with wild-type. The optimum UV-dose for induction differed for each lysogenic strain and correlated with the level of repressor

Flux line lattice in type II super conductors

International Nuclear Information System (INIS)

Manindra Kumar; Singh, Arun Kumar; Surendra Kumar

2003-01-01

The shear modules C 66 of the flux line lattice in type II super conductors can be obtained from a two body interaction between the flux lines even at large inductions B ∼ HC 2 . The potential is composed of a repulsive and an attractive part and has a range diverging at HC 2 . An explicit expression for the Ginzberg-Landau C 66 is given for arbitrary B and k' (G-L parameter). The graph for C 66 exhibits the expected maximum at a certain value of b. (author)

Peroxisome proliferator-activated receptor α ligands and modulators from dietary compounds: Types, screening methods and functions.

Science.gov (United States)

Yang, Haixia; Xiao, Lei; Wang, Nanping

2017-04-01

Peroxisome proliferator-activated receptor α (PPARα) plays a key role in lipid metabolism and glucose homeostasis and a crucial role in the prevention and treatment of metabolic diseases. Natural dietary compounds, including nutrients and phytochemicals, are PPARα ligands or modulators. High-throughput screening assays have been developed to screen for PPARα ligands and modulators in our diet. In the present review, we discuss recent advances in our knowledge of PPARα, including its structure, function, and ligand and modulator screening assays, and summarize the different types of dietary PPARα ligands and modulators. © 2016 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and John Wiley & Sons Australia, Ltd.

Globular adiponectin protects rat hepatocytes against acetaminophen-induced cell death via modulation of the inflammasome activation and ER stress: Critical role of autophagy induction.

Science.gov (United States)

Kim, Eun Hye; Park, Pil-Hoon

2018-05-24

Acetaminophen (APAP) overdose treatment causes severe liver injury. Adiponectin, a hormone predominantly produced by adipose tissue, exhibits protective effects against APAP-induced hepatotoxicity. However, the underlying mechanisms are not clearly understood. In the present study, we examined the protective effect of globular adiponectin (gAcrp) on APAP-induced hepatocyte death and its underlying mechanisms. We found that APAP (2 mM)-induced hepatocyte death was prevented by inhibition of the inflammasome. In addition, treatment with gAcrp (0.5 and 1 μg/ml) inhibited APAP-induced activation of the inflammasome, judged by suppression of interleukin-1β maturation, caspase-1 activation, and apoptosis-associated speck-like protein (ASC) speck formation, suggesting that protective effects of gAcrp against APAP-induced hepatocyte death is mediated via modulation of the inflammasome. APAP also induced ER stress and treatment with tauroursodeoxycholic acid (TUDCA), an ER chaperone and inhibitor of ER stress, abolished APAP-induced inflammasomes activation, implying that ER stress acts as signaling event leading to the inflammasome activation in hepatocytes stimulated with APAP. Moreover, gAcrp significantly suppressed APAP-induced expression of ER stress marker genes. Finally, the modulatory effects of gAcrp on ER stress and inflammasomes activation were abrogated by treatment with autophagy inhibitors, while an autophagy inducer (rapamycin) suppressed APAP-elicited ER stress, demonstrating that autophagy induction plays a crucial role in the suppression of APAP-induced inflammasome activation and ER stress by gAcrp. Taken together, these results indicate that gAcrp protects hepatocytes against APAP-induced cell death by modulating ER stress and the inflammasome activation, at least in part, via autophagy induction. Copyright © 2018. Published by Elsevier Inc.

Induction accelerator development for heavy ion fusion

International Nuclear Information System (INIS)

Reginato, L.L.

1993-05-01

For approximately a decade, the Heavy Ion Fusion Accelerator Research (HIFAR) group at LBL has been exploring the use of induction accelerators with multiple beams as the driver for inertial fusion targets. Scaled experiments have investigated the transport of space charge dominated beams (SBTE), and the current amplification and transverse emittance control in induction linacs (MBE-4) with very encouraging results. In order to study many of the beam manipulations required by a driver and to further develop economically competitive technology, a proposal has been made in partnership with LLNL to build a 10 MeV accelerator and to conduct a series of experiments collectively called the Induction Linac System Experiments (ILSE). The major components critical to the ILSE accelerator are currently under development. We have constructed a full scale induction module and we have tested a number of amorphous magnetic materials developed by Allied Signal to establish an overall optimal design. The electric and magnetic quadrupoles critical to the transport and focusing of heavy ion beams are also under development The hardware is intended to be economically competitive for a driver without sacrificing any of the physics or performance requirements. This paper will concentrate on the recent developments and tests of the major components required by the ILSE accelerator

Induction accelerator development for heavy ion fusion

International Nuclear Information System (INIS)

Reginato, L.L.

1993-05-01

For approximately a decade, the Heavy Ion Fusion Accelerator Research (HIFAR) group at LBL has been exploring the use of induction accelerators with multiple beams as the driver for inertial fusion targets. Scaled experiments have investigated the transport of space charge dominated beams (SBTE), and the current amplification and transverse emittance control in induction linacs (MBE-4) with very encouraging results. In order to study many of the beam manipulations required by a driver and to further develop economically competitive technology, a proposal has been made in partnership with LLNL to build a 10 MeV accelerator and to conduct a series of experiments collectively called the Induction Linac System Experiments (ILSE).The major components critical to the ILSE accelerator are currently under development. We have constructed a full scale induction module and we have tested a number of amorphous magnetic materials developed by Allied Signal to establish an overall optimal design. The electric and magnetic quadrupoles critical to the transport and focusing of heavy ion beams are also under development. The hardware is intended to be economically competitive for a driver without sacrificing any of the physics or performance requirements. This paper will concentrate on the recent developments and tests of the major components required by the ILSE accelerator

H-1 and N-15 resonance assignment of the second fibronectin type III module of the neural cell adhesion molecule

DEFF Research Database (Denmark)

Kiselyov, Vladislav V; Berezin, Vladimir; Bock, Elisabeth

2008-01-01

We report here the NMR assignment of the second fibronectin type III module of the neural cell adhesion molecule (NCAM). This module has previously been shown to interact with the fibroblast growth factor receptor (FGFR), and the FGFR-binding site was mapped by NMR to the FG-loop region of the mo......We report here the NMR assignment of the second fibronectin type III module of the neural cell adhesion molecule (NCAM). This module has previously been shown to interact with the fibroblast growth factor receptor (FGFR), and the FGFR-binding site was mapped by NMR to the FG-loop region...... of the module. The FG-loop region also contains a putative nucleotide-binding motif, which was shown by NMR to interact with ATP. Furthermore, ATP was demonstrated to inhibit binding of the second F3 module of NCAM to FGFR....

Time-dependent two-temperature chemically non-equilibrium modelling of high-power Ar-N2 pulse-modulated inductively coupled plasmas at atmospheric pressure

International Nuclear Information System (INIS)

Tanaka, Yasunori

2006-01-01

A time-dependent, two-dimensional, two-temperature and chemical non-equilibrium model was developed for high-power Ar-N 2 pulse-modulated inductively coupled plasmas (PMICPs) at atmospheric pressure. The high-power PMICP is a new technique for sustaining high-power induction plasmas. It can control the plasma temperature and radical densities in the time domain. The PMICP promotes non-equilibrium effects by a sudden application of electric field, even in the high-power density plasmas. The developed model accounts separately for the time-dependent energy conservation equations of electrons and heavy particles. This model also considers reaction heat effects and energy transfer between electrons and heavy particles as well as enthalpy flow resulting from diffusion caused by the particle density gradient. Chemical non-equilibrium effects are also taken into account by solving time-dependent mass conservation equations for each particle, considering diffusion, convection and net production terms resulting from 30 chemical reactions. Transport and thermodynamic properties of Ar-N 2 plasmas are calculated self-consistently using the first order approximation of the Chapman-Enskog method at each position and iteration using the local particle composition, heavy particle temperature and electron temperature. This model is useful to discuss time evolution in temperature, gas flow fields and distribution of chemical species

Core reset system design for linear induction accelerator

International Nuclear Information System (INIS)

Durga Praveen Kumar, D.; Mitra, S.; Sharma, Archana; Nagesh, K.V.; Chakravarthy, D.P.

2006-01-01

A repetitive pulsed power system based Linear Induction Accelerator (LIA-200) is being developed at BARC to get an electron beam of 200keV, 5kA, 50ns, 10-100 Hz. Amorphous core is the heart of these accelerators. It serves various functions in different subsystems viz. pulse power modulator, pulse transformer, magnetic switches and induction cavities. One of the factors that make the magnetic components compact is utilization of the total flux swing available in the core. In the present system, magnetic switches, pulse transformers, and induction cavity are designed to avail the full flux swing available in the core. For achieving this objective, flux density in the core has to be kept at the reverse saturation, before the main pulse is applied. The electrical circuit which makes it possible is called the core reset system. In this paper the details of core reset system designed for LIA-200 are described. (author)

Stability improvement of induction generator-based wind turbine systems

DEFF Research Database (Denmark)

Chen, Zhe; Hu, Y.; Blaabjerg, Frede

2007-01-01

The stability improvement of induction-generator-based wind turbine systems under power system fault conditions has been studied. Two types of generators are considered, namely rotor short-circuited induction generators and dynamic slip-controlled wound rotor induction generators. The factors...... affecting the stability are analysed. The characteristics of the induction-generator-based wind turbines are described, and possible methods of improving stability of the wind generators are discussed. The system modelling is presented, and then the discussed methods of improving stability are investigated...

Design and Comparison Direct Torque Control Techniques for Induction Motors

DEFF Research Database (Denmark)

Blaabjerg, Frede; Kazmierkowski, Marian P.; Zelechowski, Marcin

2005-01-01

In this paper a comparison of two significant control methods of induction motor are presented. The first one is a classical Direct Torque and Flux Control (DTC) and is compared with a scheme, which uses Space Vector Modulator (DTC-SVM). A comparison in respect to dynamic and steady state...

Induction Heating Process Design Using COMSOL Multiphysics Software

Directory of Open Access Journals (Sweden)

Andy Triwinarko

2011-08-01

Full Text Available Induction heating is clean environmental heating process due to a non-contact heating process. There is lots of the induction heating type that be used in the home appliance but it is still new technology in Indonesia. The main interesting area of the induction heating design is the efficiency of the usage of energy and choice of the plate material. COMSOL Multiphysics Software can be used to simulate and estimate the induction heating process. Therefore, the software can be used to design the induction heating process that will have a optimum efficiency. The properties of the induction heating design were also simulated and analyzed such as effect of inductors width, inductors distance, and conductive plate material. The result was shown that the good design of induction heating must have a short width and distance inductor and used silicon carbide as material plate with high frequency controller.

Striking similarity in the gene expression levels of individual Myc module members among ESCs, EpiSCs, and partial iPSCs.

Directory of Open Access Journals (Sweden)

Masataka Hirasaki

Full Text Available Predominant transcriptional subnetworks called Core, Myc, and PRC modules have been shown to participate in preservation of the pluripotency and self-renewality of embryonic stem cells (ESCs. Epiblast stem cells (EpiSCs are another cell type that possesses pluripotency and self-renewality. However, the roles of these modules in EpiSCs have not been systematically examined to date. Here, we compared the average expression levels of Core, Myc, and PRC module genes between ESCs and EpiSCs. EpiSCs showed substantially higher and lower expression levels of PRC and Core module genes, respectively, compared with those in ESCs, while Myc module members showed almost equivalent levels of average gene expression. Subsequent analyses revealed that the similarity in gene expression levels of the Myc module between these two cell types was not just overall, but striking similarities were evident even when comparing the expression of individual genes. We also observed equivalent levels of similarity in the expression of individual Myc module genes between induced pluripotent stem cells (iPSCs and partial iPSCs that are an unwanted byproduct generated during iPSC induction. Moreover, our data demonstrate that partial iPSCs depend on a high level of c-Myc expression for their self-renewal properties.

Inverter-Current-Feedback Resonance-Suppression Method for LCL-Type DG System to Reduce Resonance-Frequency Offset and Grid-Inductance Effect

DEFF Research Database (Denmark)

Zhou, Leming; Zhou, Xiaoping; Chen, Yandong

2018-01-01

For the LCL-type grid-connected distributed generation system, the grid-current-feedback active damping (GCFAD) methods have a conflict between the resonance-suppression ability and harmonic-currents amplification. For this, an inverter-current-feedback reso-nance-suppression (ICFRS) method without...... additional sensors is proposed to reduce resonance-frequency offset and grid-inductance effect due to its unattenuated damping characteristic under high-frequency bandwidth. By analyzing two types of equivalent impedance models of ICFRS and GCFAD with a high-pass filter (HPF), GCFAD can suppress...

Inductively coupled plasma-induced defects in n-type GaN studied from Schottky diode characteristics

International Nuclear Information System (INIS)

Nakamura, W.; Tokuda, Y.; Ueda, H.; Kachi, T.

2006-01-01

Inductively coupled plasma-(ICP-)induced defects in n-type GaN have been studied from current-voltage (I-V) characteristics and deep-level transient spectroscopy (DLTS) for Schottky diodes fabricated on etched surfaces. The samples after ICP etching show the ohmic I-V characteristics. Schottky characteristics are obtained after annealing at 600 and 800 deg. C in N 2 , but are not restored to that of the control samples. DLTS shows that the effect of ICP etching is small on the region beyond 80 nm from the surface. These results suggest that there remain ICP-induced damage in the near-surface region after thermal annealing

Induction linacs and pulsed power

International Nuclear Information System (INIS)

Caporaso, G.J.

1995-01-01

Progress in electronic power conversion technology is making possible a new class of induction linacs that can operate at extremely high repetition rates. Advances in insulator technology, pulse forming line design and switching may also lead to a new type of high current accelerator with accelerating gradients at least an order of magnitude greater than those attainable today. The evolution of the induction accelerator pulsed power system will be discussed along with some details of these emerging technologies which are at the frontiers of accelerator technology

Modulation of ambient temperature promotes inflammation and initiates atherosclerosis in wild type C57BL/6 mice

Directory of Open Access Journals (Sweden)

Daniel A. Giles

2016-11-01

Full Text Available Objectives: Obesity and obesity-associated inflammation is central to a variety of end-organ sequelae including atherosclerosis, a leading cause of death worldwide. Although mouse models have provided important insights into the immunopathogenesis of various diseases, modeling atherosclerosis in mice has proven difficult. Specifically, wild-type (WT mice are resistant to developing atherosclerosis, while commonly used genetically modified mouse models of atherosclerosis are poor mimics of human disease. The lack of a physiologically relevant experimental model of atherosclerosis has hindered the understanding of mechanisms regulating disease development and progression as well as the development of translational therapies. Recent evidence suggests that housing mice within their thermoneutral zone profoundly alters murine physiology, including both metabolic and immune processes. We hypothesized that thermoneutral housing would allow for augmentation of atherosclerosis induction and progression in mice. Methods: ApoE−/− and WT mice were housed at either standard (TS or thermoneutral (TN temperatures and fed either a chow or obesogenic “Western” diet. Analysis included quantification of (i obesity and obesity-associated downstream sequelae, (ii the development and progression of atherosclerosis, and (iii inflammatory gene expression pathways related to atherosclerosis. Results: Housing mice at TN, in combination with an obesogenic “Western” diet, profoundly augmented obesity development, exacerbated atherosclerosis in ApoE−/− mice, and initiated atherosclerosis development in WT mice. This increased disease burden was associated with altered lipid profiles, including cholesterol levels and fractions, and increased aortic plaque size. In addition to the mild induction of atherosclerosis, we similarly observed increased levels of aortic and white adipose tissue inflammation and increased circulating immune cell expression of pathways

Classes of modules

CERN Document Server

Dauns, John

2006-01-01

Because traditional ring theory places restrictive hypotheses on all submodules of a module, its results apply only to small classes of already well understood examples. Often, modules with infinite Goldie dimension have finite-type dimension, making them amenable to use with type dimension, but not Goldie dimension. By working with natural classes and type submodules (TS), Classes of Modules develops the foundations and tools for the next generation of ring and module theory. It shows how to achieve positive results by placing restrictive hypotheses on a small subset of the complement submodules, Furthermore, it explains the existence of various direct sum decompositions merely as special cases of type direct sum decompositions. Carefully developing the foundations of the subject, the authors begin by providing background on the terminology and introducing the different module classes. The modules classes consist of torsion, torsion-free, s[M], natural, and prenatural. They expand the discussion by exploring...

Early cytokine modulation after the rapid induction phase of sublingual immunotherapy with mite monomeric allergoids.

Science.gov (United States)

Di Gioacchino, M; Perrone, A; Petrarca, C; Di Claudio, F; Mistrello, G; Falagiani, P; Dadorante, V; Verna, N; Braga, M; Ballone, E; Cavallucci, E

2008-01-01

The influence of different treatment schedules of sublingual immunotherapy (SLIT) in activating IL-10-producing T-cells, crucial in inducing allergen-specific tolerance, is not completely understood. The present work was designed to evaluate allergen driven interleukin release by mononuclear cells in the early phase of SLIT, after application of different induction schemes. Twenty mite-allergic patients were enrolled, 10 (group A) treated with a traditional 98 day induction scheme and 10 (group B) with a 16 day scheme with monomeric allergoid vaccine. At the end of the induction phase, the cumulative doses taken by group A and group B patients were equivalent to 50.5 and 50.3 microg of mite group 1 allergens, respectively. The release of Th1-, Th2- and Treg-related interleukins was assessed in culture supernatants of 5 microg/ml Der-p1-stimulated mononuclear cells, isolated before and after the induction phases. No relevant treatment-related side effects were observed. Interleukin release was similar in the two groups at the enrolment. Non-stimulated and Der p 1 stimulated release of studied cytokines was similar in the two groups at enrolment. Der p 1 stimulation significantly increased IL-10 release (pallergoids are utilized.

Development of FET-switched induction accelerator cells for heavy-ion fusion recirculators

International Nuclear Information System (INIS)

Newton, M.A.; Cravey, W.R.; Hawkins, S.A.; Kirbie, H.C.; Ollis, C.W.

1993-01-01

The ''recirculator,'' a recirculating heavy-ion induction accelerator, has been identified as a promising approach for an inertial fusion driver. One of the technical challenges to building a recirculator is the requirement for a modulator that can drive the induction accelerator cells at repetition rates ≥ 100 kHz with variable pulse width and pulse repetition rate capability. A high repetition rate modulator and cell is presently being developed for use on a proposed heavy-ion recirculator. The goal is to develop an array of field-effect transistors to switch 5 kV, 1 μs pulses onto a Metglas induction core at pulse rates exceeding 100 kHz. Each transistor in the array is driven by a fiber-optic isolated gate signal that is powered by a dc/dc converter. The circuit architecture provides for core reset between pulses and produces bursts of pulses that are variable in pulse width and prf. The transistor switching array, energy storage capacitors, reset circuit and cell core are all combined into a single compact, low-impedance package. Progress of this development work will be presented with supporting data

Cholinergic Modulation of Type 2 Immune Responses

Directory of Open Access Journals (Sweden)

Goele Bosmans

2017-12-01

Full Text Available In recent years, the bidirectional relationship between the nervous and immune system has become increasingly clear, and its role in both homeostasis and inflammation has been well documented over the years. Since the introduction of the cholinergic anti-inflammatory pathway, there has been an increased interest in parasympathetic regulation of both innate and adaptive immune responses, including T helper 2 responses. Increasing evidence has been emerging suggesting a role for the parasympathetic nervous system in the pathophysiology of allergic diseases, including allergic rhinitis, asthma, food allergy, and atopic dermatitis. In this review, we will highlight the role of cholinergic modulation by both nicotinic and muscarinic receptors in several key aspects of the allergic inflammatory response, including barrier function, innate and adaptive immune responses, and effector cells responses. A better understanding of these cholinergic processes mediating key aspects of type 2 immune disorders might lead to novel therapeutic approaches to treat allergic diseases.

Mapping Between Semantic Graphs and Sentences in Grammar Induction System

Directory of Open Access Journals (Sweden)

Laszlo Kovacs

2010-06-01

Full Text Available The proposed transformation module performs mapping be-
tween two di®erent knowledge representation forms used in grammar induction systems. The kernel knowledge representation form is a special predicate centered conceptual graph called ECG. The ECG provides a semantic-based, language independent description of the environment. The other base representation form is some kind of language. The sentences of the language should meet the corresponding grammatical rules. The pilot project demonstrates the functionality of a translator module using this transformation engine between the ECG graph and the Hungarian language.

Feasibility analysis of a novel hybrid-type superconducting circuit breaker in multi-terminal HVDC networks

Science.gov (United States)

Khan, Umer Amir; Lee, Jong-Geon; Seo, In-Jin; Amir, Faisal; Lee, Bang-Wook

2015-11-01

Voltage source converter-based HVDC systems (VSC-HVDC) are a better alternative than conventional thyristor-based HVDC systems, especially for developing multi-terminal HVDC systems (MTDC). However, one of the key obstacles in developing MTDC is the absence of an adequate protection system that can quickly detect faults, locate the faulty line and trip the HVDC circuit breakers (DCCBs) to interrupt the DC fault current. In this paper, a novel hybrid-type superconducting circuit breaker (SDCCB) is proposed and feasibility analyses of its application in MTDC are presented. The SDCCB has a superconducting fault current limiter (SFCL) located in the main current path to limit fault currents until the final trip signal is received. After the trip signal the IGBT located in the main line commutates the current into a parallel line where DC current is forced to zero by the combination of IGBTs and surge arresters. Fault simulations for three-, four- and five-terminal MTDC were performed and SDCCB performance was evaluated in these MTDC. Passive current limitation by SFCL caused a significant reduction of fault current interruption stress in the SDCCB. It was observed that the DC current could change direction in MTDC after a fault and the SDCCB was modified to break the DC current in both the forward and reverse directions. The simulation results suggest that the proposed SDCCB could successfully suppress the DC fault current, cause a timely interruption, and isolate the faulty HVDC line in MTDC.

Preliminary results of Linear Induction Accelerator LIA-200

Energy Technology Data Exchange (ETDEWEB)

Sharma, Archana; Senthil, K; Kumar, D D Praveen; Mitra, S; Sharma, V; Patel, A; Sharma, D K; Rehim, R; Kolge, T S; Saroj, P C; Acharya, S; Amitava, Roy; Rakhee, M; Nagesh, K V; Chakravarthy, D P, E-mail: aroy@barc.gov.i, E-mail: arsharma@barc.gov.i [Accelerator and Pulse Power Division, Bhabha Atomic Research Centre, Trombay, Mumbai 400 085 (India)

2010-05-15

Repetitive Pulsed Power Technology is being developed keeping in mind the potential applications of this technology in material modifications, disinfections of water, timber, and food pasteurization etc. BARC has indigenously developed a Linear Induction Accelerator (LIA-200) rated for 200 kV, 4 kA, 100 ns, 10 Hz. The satisfactory performance of all the sub-systems including solid state power modulator, amorphous core based pulsed transformers, magnetic switches, water capacitors, water pulse- forming line, induction adder and field-emission diode have been demonstrated. This paper presents some design details and operational results of this pulsed power system. It also highlights the need for further research and development to build reliable and economic high-average power systems for industrial applications.

Solid-State Modulators for RF And Fast Kickers

Energy Technology Data Exchange (ETDEWEB)

Cook, E.G.; Akana, G.L.; Gower, E.J.; Hawkins, S.A.; Hickman, B.C.; /LLNL, Livermore; Brooksby, C.A.; /NONE - BECHTEL NEVADA LAS VEGAS; Cassel, R.L.; de Lamare, J.E.; Nguyen, M.N.; Pappas, G.C.; /SLAC

2006-03-14

As the switching capabilities of solid-state devices increase, these devices are being incorporated into modulator designs for high voltage accelerator applications. Solid-state modulators based on inductive adder circuit topology have demonstrated great versatility with regard to pulse width and pulse repetition rate while maintaining fast pulse rise and fall times. Additionally, these modulators are capable of being scaled to higher output voltage and power levels. An explanation of the basic circuit operation will be presented as well as test data of several different hardware systems.

SOLID-STATE MODULATORS FOR RF AND FAST KICKERS

International Nuclear Information System (INIS)

Cook, E G; Akana, G; Gower, E J; Hawkins, S A; Hickman, B C; Brooksby, C A; Cassel, R L; De Lamare, J E; Nguyen, M N; Pappas, G C

2005-01-01

As the switching capabilities of solid-state devices increase, these devices are being incorporated into modulator designs for high voltage accelerator applications. Solid-state modulators based on inductive adder circuit topology have demonstrated great versatility with regard to pulse width and pulse repetition rate while maintaining fast pulse rise and fall times. Additionally, these modulators are capable of being scaled to higher output voltage and power levels. An explanation of the basic circuit operation will be presented as well as test data of several different hardware systems

SOLID-STATE MODULATORS FOR RF AND FAST KICKERS

Energy Technology Data Exchange (ETDEWEB)

Cook, E G; Akana, G; Gower, E J; Hawkins, S A; Hickman, B C; Brooksby, C A; Cassel, R L; De Lamare, J E; Nguyen, M N; Pappas, G C

2005-05-05

As the switching capabilities of solid-state devices increase, these devices are being incorporated into modulator designs for high voltage accelerator applications. Solid-state modulators based on inductive adder circuit topology have demonstrated great versatility with regard to pulse width and pulse repetition rate while maintaining fast pulse rise and fall times. Additionally, these modulators are capable of being scaled to higher output voltage and power levels. An explanation of the basic circuit operation will be presented as well as test data of several different hardware systems.

Solid-State Modulators for RF and Fast Kickers

CERN Document Server

Cook, Edward; Brooksby, Craig A; Cassel, Richard; De Lamare, Jeffrey E; Gower, Edward J; Hawkins, Steven; Hickman, Bradley C; Nguyen, Minh N; Pappas, Chris

2005-01-01

As the capabilities of solid-state devices increase, these devices are being incorporated into modulator designs for high voltage accelerator applications. Solid-state modulators based on inductive adder circuit topology have demonstrated great versatility with regard to pulse width and pulse repetition rate while maintaining fast pulse rise and fall times. Additionally, these modulators are capable of being scaled to higher output voltage and power levels. An explanation of the basic circuit operation will be presented as well as test data of several different hardware systems.

Asymptotic analysis of the longitudinal instability of a heavy ion induction linac

International Nuclear Information System (INIS)

Lee, E.P.; Smith, L.

1990-09-01

An Induction Linac accelerating high ion currents at sub-relativistic energies is predicted to exhibit unstable growth of current fluctuations at low frequencies. The instability is driven by the interaction between the beam and complex impedance of the induction modules. In general, the detailed form of the growing disturbance depends on the initial perturbation and ratio of pulse length to accelerator length, as well as the specific form of the impedance. An asymptotic analysis of the several regimes of interest is presented. 1 ref

Performance of 7-cells Dye Sensitized Solar Module in Z-type Series Interconnection

Science.gov (United States)

Nur Anggraini, Putri; Muliani, Lia; Maulani Nursam, Natalita; Hidayat, Jojo

2018-01-01

Dye sensitized solar cells (DSSC) is becoming attractive research topic as third generation solar cells technology since it provides clean energy and low cost fabrication. In this study, DSSC was fabricated into module scale, which is important for practical applications. The module was prepared in sandwich structure consisting of TiO2 working electrode and Pt counter electrode on conductive substrate with an area of 100 mm x 100 mm, which was distributed into seven active cells. TiO2 paste was deposited on FTO glass as working electrode with a size of 10 mm x 98 mm per unit cell by screen printing method. Each cell was connected in Z-type series that able to produce high voltage. I - V measurement was applied in two methods consisting of laboratory testing using sun simulator under 500 W/m2 of illumination and outdoor testing using a digital multimeter under direct sunlight. The result shows that DSSC module has photoconversion efficiency of 1.08% and 1.17% for laboratory and outdoor testing, respectively. The module was also tested in three different times to monitor its stability performance.

A novel interference mechanism by a type IIIB CRISPR-Cmr module in Sulfolobus

DEFF Research Database (Denmark)

Deng, Ling; Garrett, Roger Antony; Shah, Shiraz Ali

2013-01-01

Recent studies on CRISPR-based adaptive immune systems have revealed extensive structural and functional diversity of the interference complexes which often coexist intracellularly. The archaeon Sulfolobus islandicus REY15A encodes three interference modules, one of type IA and two of type IIIB...... targeting. A rationale is provided for the intracellular coexistence of the different interference systems in S.¿islandicus REY15A which cooperate functionally by sharing a single Cas6 protein for crRNA processing and utilize crRNA products from identical CRISPR spacers....

Feasibility Study of Moderately Accelerated Intensity-Modulated Radiotherapy Plus Concurrent Weekly Cisplatin After Induction Chemotherapy in Locally Advanced Head-and Neck Cancer

International Nuclear Information System (INIS)

Morganti, Alessio G.; Mignogna, Samantha; Deodato, Francesco; Massaccesi, Mariangela; Cilla, Savino; Calista, Franco; Serafini, Giovanni; Digesu, Cinzia; Macchia, Gabriella; Picardi, Vincenzo; Caravatta, Luciana; Di Lullo, Liberato; Giglio, Gianfranco; Sallustio, Giuseppina; Piermattei, Angelo

2011-01-01

Purpose: To evaluate the feasibility and efficacy of moderately accelerated intensity-modulated radiation therapy (IMRT) along with weekly cisplatin, after induction chemotherapy, in patients with locally advanced unresectable head and neck cancer (HNC). Methods and Materials: Patients with Stage III or IV locally advanced HNC, without progressive disease after three courses of induction chemotherapy, received concurrent chemo-IMRT (weekly cisplatin 30 mg/m 2 plus simultaneous integrated boost IMRT). A total of 67.5 Gy in 30 fractions were delivered to primary tumor and involved nodes, 60 Gy in 30 fractions to high-risk nodal areas, and 55.5 Gy in 30 fractions to low-risk nodal areas. Results: In all, 36 patients (median age, 56 years) with International Union Against Cancer (UICC) Stage III (n = 5) and IV (n = 31) were included. Of the 36 patients, 17 had received CF (cisplatin and 5-fluorouracil (CF) and 19 had received docetaxel cisplatin and 5-fluorouracil (DCF). During concurrent chemoradiation, 11 of 36 patients (30.5%) experienced Grade III mucositis (CF, 47%; DCF, 15%; p < 0.04). Grade III pharyngeal-esophageal toxicity was observed in 5 of 19 patients (26.3%; CF, 0.0%; DCF, 26.3%; p = 0.02). Two patients died of complications (5.5%). After chemoradiation, the complete response rate was 63.8%. Two-year local control was 88.7%. Two-year progression free survival and overall survival were 74.5% and 60.9%, respectively. Conclusions: In our experience, a moderately accelerated chemo-IMRT was feasible after induction chemotherapy. However, a noteworthy early death rate of 5.5% was observed. Intensive supportive care strategies should be defined to better manage radiation-induced toxic effects. Longer follow-up is required to determine the incidence of late radiation toxicities and tumor control rates.

Different types of laughter modulate connectivity within distinct parts of the laughter perception network.

Science.gov (United States)

Wildgruber, Dirk; Szameitat, Diana P; Ethofer, Thomas; Brück, Carolin; Alter, Kai; Grodd, Wolfgang; Kreifelts, Benjamin

2013-01-01

Laughter is an ancient signal of social communication among humans and non-human primates. Laughter types with complex social functions (e.g., taunt and joy) presumably evolved from the unequivocal and reflex-like social bonding signal of tickling laughter already present in non-human primates. Here, we investigated the modulations of cerebral connectivity associated with different laughter types as well as the effects of attention shifts between implicit and explicit processing of social information conveyed by laughter using functional magnetic resonance imaging (fMRI). Complex social laughter types and tickling laughter were found to modulate connectivity in two distinguishable but partially overlapping parts of the laughter perception network irrespective of task instructions. Connectivity changes, presumably related to the higher acoustic complexity of tickling laughter, occurred between areas in the prefrontal cortex and the auditory association cortex, potentially reflecting higher demands on acoustic analysis associated with increased information load on auditory attention, working memory, evaluation and response selection processes. In contrast, the higher degree of socio-relational information in complex social laughter types was linked to increases of connectivity between auditory association cortices, the right dorsolateral prefrontal cortex and brain areas associated with mentalizing as well as areas in the visual associative cortex. These modulations might reflect automatic analysis of acoustic features, attention direction to informative aspects of the laughter signal and the retention of those in working memory during evaluation processes. These processes may be associated with visual imagery supporting the formation of inferences on the intentions of our social counterparts. Here, the right dorsolateral precentral cortex appears as a network node potentially linking the functions of auditory and visual associative sensory cortices with those of the

Different types of laughter modulate connectivity within distinct parts of the laughter perception network.

Directory of Open Access Journals (Sweden)

Dirk Wildgruber

Full Text Available Laughter is an ancient signal of social communication among humans and non-human primates. Laughter types with complex social functions (e.g., taunt and joy presumably evolved from the unequivocal and reflex-like social bonding signal of tickling laughter already present in non-human primates. Here, we investigated the modulations of cerebral connectivity associated with different laughter types as well as the effects of attention shifts between implicit and explicit processing of social information conveyed by laughter using functional magnetic resonance imaging (fMRI. Complex social laughter types and tickling laughter were found to modulate connectivity in two distinguishable but partially overlapping parts of the laughter perception network irrespective of task instructions. Connectivity changes, presumably related to the higher acoustic complexity of tickling laughter, occurred between areas in the prefrontal cortex and the auditory association cortex, potentially reflecting higher demands on acoustic analysis associated with increased information load on auditory attention, working memory, evaluation and response selection processes. In contrast, the higher degree of socio-relational information in complex social laughter types was linked to increases of connectivity between auditory association cortices, the right dorsolateral prefrontal cortex and brain areas associated with mentalizing as well as areas in the visual associative cortex. These modulations might reflect automatic analysis of acoustic features, attention direction to informative aspects of the laughter signal and the retention of those in working memory during evaluation processes. These processes may be associated with visual imagery supporting the formation of inferences on the intentions of our social counterparts. Here, the right dorsolateral precentral cortex appears as a network node potentially linking the functions of auditory and visual associative sensory cortices

Anandamide attenuates Th-17 cell-mediated delayed-type hypersensitivity response by triggering IL-10 production and consequent microRNA induction.

Directory of Open Access Journals (Sweden)

Austin R Jackson

Full Text Available Endogenous cannabinoids [endocannabinoids] are lipid signaling molecules that have been shown to modulate immune functions. However, their role in the regulation of Th17 cells has not been studied previously. In the current study, we used methylated Bovine Serum Albumin [mBSA]-induced delayed type hypersensitivity [DTH] response in C57BL/6 mice, mediated by Th17 cells, as a model to test the anti-inflammatory effects of endocannabinoids. Administration of anandamide [AEA], a member of the endocannabinoid family, into mice resulted in significant mitigation of mBSA-induced inflammation, including foot pad swelling, cell infiltration, and cell proliferation in the draining lymph nodes [LN]. AEA treatment significantly reduced IL-17 and IFN-γ production, as well as decreased RORγt expression while causing significant induction of IL-10 in the draining LNs. IL-10 was critical for the AEA-induced mitigation of DTH response inasmuch as neutralization of IL-10 reversed the effects of AEA. We next analyzed miRNA from the LN cells and found that 100 out of 609 miRNA species were differentially regulated in AEA-treated mice when compared to controls. Several of these miRNAs targeted proinflammatory mediators. Interestingly, many of these miRNA were also upregulated upon in vitro treatment of LN cells with IL-10. Together, the current study demonstrates that AEA may suppress Th-17 cell-mediated DTH response by inducing IL-10 which in turn triggers miRNA that target proinflammatory pathways.

Weyl modules, demazure modules, KR-modules, crystals, fusion products and limit constructions

OpenAIRE

Fourier, G.; Littelmann, P.

2007-01-01

We study finite dimensional representations of current algebras, loop algebras and their quantized versions. For the current algebra of a simple Lie algebra of type {\\tt ADE}, we show that Kirillov-Reshetikhin modules and Weyl modules are in fact all Demazure modules. As a consequence one obtains an elementary proof of the dimension formula for Weyl modules for the current and the loop algebra. Further, we show that the crystals of the Weyl and the Demazure module are the same up to some addi...

Steviol Glycosides Modulate Glucose Transport in Different Cell Types

Science.gov (United States)

Rizzo, Benedetta; Zambonin, Laura; Leoncini, Emanuela; Vieceli Dalla Sega, Francesco; Prata, Cecilia; Fiorentini, Diana; Hrelia, Silvana

2013-01-01

Extracts from Stevia rebaudiana Bertoni, a plant native to Central and South America, have been used as a sweetener since ancient times. Currently, Stevia extracts are largely used as a noncaloric high-potency biosweetener alternative to sugar, due to the growing incidence of type 2 diabetes mellitus, obesity, and metabolic disorders worldwide. Despite the large number of studies on Stevia and steviol glycosides in vivo, little is reported concerning the cellular and molecular mechanisms underpinning the beneficial effects on human health. The effect of four commercial Stevia extracts on glucose transport activity was evaluated in HL-60 human leukaemia and in SH-SY5Y human neuroblastoma cells. The extracts were able to enhance glucose uptake in both cellular lines, as efficiently as insulin. Our data suggest that steviol glycosides could act by modulating GLUT translocation through the PI3K/Akt pathway since treatments with both insulin and Stevia extracts increased the phosphorylation of PI3K and Akt. Furthermore, Stevia extracts were able to revert the effect of the reduction of glucose uptake caused by methylglyoxal, an inhibitor of the insulin receptor/PI3K/Akt pathway. These results corroborate the hypothesis that Stevia extracts could mimic insulin effects modulating PI3K/Akt pathway. PMID:24327825

Modulation of type I interferon induction by porcine reproductive and respiratory syndrome virus and degradation of CREB-binding protein by non-structural protein 1 in MARC-145 and HeLa cells

International Nuclear Information System (INIS)

Kim, Oekyung; Sun Yan; Lai, Frances W.; Song Cheng; Yoo, Dongwan

2010-01-01

Porcine reproductive and respiratory syndrome (PRRS) is an emerged disease of swine characterized by negligible response of type I IFNs and viral persistence. We show that the PRRSV non-structural protein 1 (Nsp1) is the viral component responsible for modulation of IFN response. Nsp1 blocked dsRNA-induced IRF3 and IFN promoter activities. Nsp1 did not block phosphorylation and nuclear translocation of IRF3 but inhibited IRF3 association with CREB-binding protein (CBP) in the nucleus. While IRF3 was stable, CBP was degraded, and CBP degradation was proteasome-dependent, suggesting that CBP degradation is not due to the protease activity of Nsp1 but an intermediary is involved. Our data suggest that the Nsp1-mediated CBP degradation inhibits the recruitment of CBP for enhanceosome assembly, leading to the block of IFN response. CBP degradation is a novel strategy for viral evasion from the host response, and Nsp1 may form a new class of viral antagonists for IFN modulation.

Fault diagnosis of induction motors

CERN Document Server

Faiz, Jawad; Joksimović, Gojko

2017-01-01

This book is a comprehensive, structural approach to fault diagnosis strategy. The different fault types, signal processing techniques, and loss characterisation are addressed in the book. This is essential reading for work with induction motors for transportation and energy.

Modulation of Current Source Inverter

Directory of Open Access Journals (Sweden)

Golam Reza Arab Markadeh

2011-04-01

Full Text Available Direct torque control with Current Source Inverter (CSI instead of voltage source inverter is so appropriate because of determining the torque of induction motor with machine current and air gap flux. In addition, Space-Vector Modulation (SVM is a more proper method for CSI because of low order harmonics reduction, lower switching frequency and easier implementation. This paper introduces the SVM method for CSI and uses the proposed inverter for vector control of an induction motor. The simulation results illustrate fast dynamic response and desirable torque and speed output. Fast and accurate response to changes of speed and load torque reference completely proves the prominence of this method.

Survey of variable speed operation of wind turbines

Energy Technology Data Exchange (ETDEWEB)

Carlson, Ola; Hylander, J.; Thorborg, K. [Chalmers Univ. of Technology, Goeteborg (Sweden). Dept. of Electric Power Engineering

1996-12-01

During the last five years the production and operation of variable-speed wind turbines have advanced from a few experimental machines to a serial production of at least 10 MW of installed capacity of variable speed machines per week. The rated power of serial wind turbines is today around 600 kW and for the prototypes up to 3000 kW. Variable speed operation of wind turbines can be obtained with several different types of electrical generating systems, such as synchronous generators with diode rectifiers and thyristor inverters or induction generators with IGBT-converters, for the wide speed range. For the narrow speed range the wound motor induction generator with a rotor cascade or a controlled rotor resistance is preferable. The development of permanent magnetic material and the reduction of costs of the power electronic components have opened a possibility of designing cost-effective wind turbines with a directly driven generator. Pitch control together with variable speed will make it possible to limit the power variation within a few percent, 2 to 5 %, of the rated power. 7 refs, 4 figs, 2 tabs

Cross-Modulation Interference with Lateralization of Mixed-Modulated Waveforms

Science.gov (United States)

Hsieh, I-Hui; Petrosyan, Agavni; Goncalves, Oscar F.; Hickok, Gregory; Saberi, Kourosh

2010-01-01

Purpose: This study investigated the ability to use spatial information in mixed-modulated (MM) sounds containing concurrent frequency-modulated (FM) and amplitude-modulated (AM) sounds by exploring patterns of interference when different modulation types originated from different loci as may occur in a multisource acoustic field. Method:…

E-type cyclins modulate telomere integrity in mammalian male meiosis.

Science.gov (United States)

Manterola, Marcia; Sicinski, Piotr; Wolgemuth, Debra J

2016-06-01

We have shown that E-type cyclins are key regulators of mammalian male meiosis. Depletion of cyclin E2 reduced fertility in male mice due to meiotic defects, involving abnormal pairing and synapsis, unrepaired DNA, and loss of telomere structure. These defects were exacerbated by additional loss of cyclin E1, and complete absence of both E-type cyclins produces a meiotic catastrophe. Here, we investigated the involvement of E-type cyclins in maintaining telomere integrity in male meiosis. Spermatocytes lacking cyclin E2 and one E1 allele (E1+/-E2-/-) displayed a high rate of telomere abnormalities but can progress to pachytene and diplotene stages. We show that their telomeres exhibited an aberrant DNA damage repair response during pachynema and that the shelterin complex proteins TRF2 and RAP2 were significantly decreased in the proximal telomeres. Moreover, the insufficient level of these proteins correlated with an increase of γ-H2AX foci in the affected telomeres and resulted in telomere associations involving TRF1 and telomere detachment in later prophase-I stages. These results suggest that E-type cyclins are key modulators of telomere integrity during meiosis by, at least in part, maintaining the balance of shelterin complex proteins, and uncover a novel role of E-type cyclins in regulating chromosome structure during male meiosis.

Intrinsic magnetic torque at low magnetic induction

International Nuclear Information System (INIS)

Doria, M.M.; Oliveira, I.G. de.

1993-01-01

Using anisotropic London theory the intrinsic magnetic torque for extreme type II uniaxial superconductors for any value of the magnetic induction is obtained. It is considered the vortex lines straight and take into account the contribution of the supercurrents flowing inside the vortex core within the London theory. It is shown that the interline and intra line free energies give opposite torque contributions, the first drives the magnetic induction parallel to the superconductor's axis of symmetry and the second orthogonal to it. At high magnetic induction torque expression obtained generalizes V. Kogan's formula since it has no free parameters other than the anisotropy γ = m 1 /m 3 and the Ginzburg-Landau parameter κ. At low magnetic induction it is proposed a way to observe vortex chains effects in the total torque based on the fact that London theory is linear and the energy to make a single vortex line in space is independent of the magnetic induction. (author)

Serializing off-the-shelf MOSFETs by Magnetically Coupling Their Gate Electrodes

DEFF Research Database (Denmark)

Dimopoulos, Emmanouil; Munk-Nielsen, Stig

2013-01-01

While the semiconductor industry struggles with the inherent trade-offs of solid-state devices, serialization of power switches, like the Metal-Oxide-Semiconductor Field Effect Transistor (MOSFET) or the Insulated Gate Bipolar Transistor (IGBT), has been proven to be an advantageous alternative...... to acquire a high-efficient, high-voltage, fast-switching device. More than twenty years of research, on the serialization of solid-state devices, have resulted into several different stacking concepts. Among the prevailing ones, the gate balancing core technique, which has demonstrated very good performance...... in strings of high-power IGBT modules. In this paper, the limitations of the gate balancing core technique, when employed to serialize low or medium power off-the-shelf switches, are identified via experimental results. A new design specification for the interwinding capacitance of the employed transformer...

A new kind of low-inductance transformer type magnetic switch (TTMS) with coaxial cylindrical conductors.

Science.gov (United States)

Zhang, Yu; Liu, Jinliang

2013-02-01

As important devices for voltage boosting and switching, respectively, pulse transformer and magnetic switch are widely used in pulsed power technology. In this paper, a new kind of transformer type magnetic switch (TTMS) with coaxial cylindrical conductors is put forward to combine the functions of voltage boosting and switching in one power device. As a compact combination device of discrete pulse transformer and magnetic switch, the compact TTMS decreases the required volume of magnetic cores in a large scale. The primary windings of the TTMS have a parallel combination structure so that the TTMS which only has 3 turns of secondary windings has a step-up ratio at 1:9. Before the magnetic core saturates, the TTMS has low unsaturated inductances of windings and good pulse response characteristics, so it can be used to substitute the Marx generator to charge the pulse forming line (PFL) at the ranges of several hundred kV and several hundred ns. After the core saturates, the cylindrical conductors can decrease the saturated inductance of the secondary windings of TTMS to a level less than 400 nH. As a result, the proposed TTMS can be used as the boosting transformer and main switch of helical Blumlein PFL to form the quasi-square voltage pulse on the 160 Ω load with a short pulse rise time only at 60 ns.

A survey of the effect of explants type, plant growth regulators and activated charcoal on callus induction in Papaver bracteatum

Directory of Open Access Journals (Sweden)

Bahman Hosseini

2015-09-01

Full Text Available Callus culture is necessary for production of suspension cell culture in plant breeding programs. Regarding to the application of Papaver bracteatum as an important medicinal plant in production of benzophenantridine alkaloids, this study was performed to find the most suitable hormone combination and explant type for achieving to high percentage of callus induction fresh weight and somatic embryogenesis in this plant. For this purpose, hypocotyl explants were cultured in ½MS media containing active charcoal (2 and 4 mgL-1 in combination of different concentrations of NAA, 2,4-D (0, 1, 2, 3 and 5 mgL-1 and BA (0, 0.1 and 0.5 mgL-1. The seed explants were cultured in same treatments without active charcoal. Also, somatic embryogesis induction using seed explants in ½MS media containing different concentrations of NAA and 2,4-D (0, 0.5, 1 and 2 mgL-1 with BA 0.5 mgL-1 were investigated. The results showed that the highest percentage of callus induction (43.6%, 54% in hypocotyls explants were obtained in the ½MS media containing 2 mgL-1 active charcoal and 2 mgL-1 2,4-D and 5 mgL-1 NAA in companion with BA 0.5 mgL-1 respectively. The maximum callus induction (84% was obtained in ½MS medium with 1 mgL-1 2,4-D without active charcoal. The highest callus fresh weight (0.35% was obtained in MS media with 0.5 mgL-1 2,4-D andthe maximum rate of somatic embryogenesis induction (77% was observed in ½MS media containing 1 mgL-1 2,4-D with 0.5 mgL-1 BA.

Electric Machine with Boosted Inductance to Stabilize Current Control

Science.gov (United States)

Abel, Steve

2013-01-01

High-powered motors typically have very low resistance and inductance (R and L) in their windings. This makes the pulse-width modulated (PWM) control of the current very difficult, especially when the bus voltage (V) is high. These R and L values are dictated by the motor size, torque (Kt), and back-emf (Kb) constants. These constants are in turn set by the voltage and the actuation torque-speed requirements. This problem is often addressed by placing inductive chokes within the controller. This approach is undesirable in that space is taken and heat is added to the controller. By keeping the same motor frame, reducing the wire size, and placing a correspondingly larger number of turns in each slot, the resistance, inductance, torque constant, and back-emf constant are all increased. The increased inductance aids the current control but ruins the Kt and Kb selections. If, however, a fraction of the turns is moved from their "correct slot" to an "incorrect slot," the increased R and L values are retained, but the Kt and Kb values are restored to the desired values. This approach assumes that increased resistance is acceptable to a degree. In effect, the heat allocated to the added inductance has been moved from the controller to the motor body, which in some cases is preferred.

A Decoupled Control of 5-Legs PWM Inverter Feeding a two Induction Motors-based Electric Vehicle Powertrain

Directory of Open Access Journals (Sweden)

Bekheïra Tabbache

2016-06-01

Full Text Available This paper proposes a traction drive system for electric vehicles (EVs with two separate induction motor drive-based wheels. In this context, two three-phase induction motors are associated to five legs power inverter which one leg is shared by two phases of the motors. The independent control of the two induction motors allows replacing the mechanical differential speeds by an equivalent electrical module called electric differential (ED. In the proposed EV powertrain based on 5-leg inverter, the challenge is to achieve a decoupled control of the induction motors to ensure the EV stability while cornering or under slippery road condition. For this, the proposed independent control uses Indirect Field Oriented Control to ensure speed and rotor flux control of each induction motor , a Pulse Width Modulation to provide the command sequences to the 5-leg inverter and electric differential to generate the an appropriate reference when the two induction motors should be controlled at different speeds. For this, a numerical implementation of the independent controls on an embedded board (TMS 320F2812 to ensure a separate control of induction motor fed by the 5-leg inverter. Moreover, the proposed control takes into account the EV context such as the EV dynamic and uses European and American normalized driving cycles. EV-specific experimental tests on a digital signal processor TMS320LF2812 are carried-out to show the effectiveness of the proposed independent control for ED in terms of robustness and stability.

CpG Type A Induction of an Early Protective Environment in Experimental Multiple Sclerosis

Directory of Open Access Journals (Sweden)

James Crooks

2017-01-01

Full Text Available Experimental autoimmune encephalomyelitis (EAE is an inflammatory, demyelinating disease of the CNS that mimics human multiple sclerosis (MS, and it is thought to be driven by Th1 and Th17 myelin-reactive cells. Although adaptive immunity is clearly pivotal in the pathogenesis of EAE, with an essential role of CD4+ T cells, little is known of early, innate responses in this experimental setting. CpG-rich oligodeoxynucleotides (ODNs, typically found in microbial genomes, are potent activators of TLR9 in plasmacytoid dendritic cells (pDCs. In this study, we compared the effects of two types of CpG, namely, type A and type B, on EAE. We found that treatment with CpG type A ODN (CpG-A, known to induce high amounts of IFN-α in pDCs, significantly reduced disease severity in EAE, relative to controls (12.63±1.86 versus 23.49±1.46, resp.; p=0.001. Treatment also delayed onset of neurological deficits and reduced spinal cord demyelination, while increasing the percentage of splenic regulatory (Foxp3+ CD4+ T cells. CpG-A likewise reduced the levels of IL-17 and IFN-γ in the CNS. Mechanistic insight into those events showed that CpG-A promoted a regulatory phenotype in pDCs. Moreover, adoptive transfer of pDCs isolated from CpG-A-treated mice inhibited CNS inflammation and induced disease remission in acute-phase EAE. Our data thus identify a link between TLR9 activation by specific ligands and the induction of tolerance via innate immunity mechanisms.

A new power supply regulated PWM-ZCS supplied in current: analysis, project and experiments; Uma nova fonte chaveada PWM-ZCS alimentada em corrente: analise, projeto e experimentacao

Energy Technology Data Exchange (ETDEWEB)

Barbosa, Peter Mantovanelli

1993-10-01

This work introduces a new power supply by PWM, operating at constant frequency, with soft communication. The new topology uses only two active switches and absorbs the transformer leakage inductance. Besides, the soft communication takes place with no conduction loss penalty, in comparison with conventional hard switch PWM converters. Principle of operation, analysis, design and experimentation results taken from laboratory prototype rated at 400 W/48 v, 40 Khz, using IGBT are presented. (author) 10 refs., 71 figs.

Rectangular waveform linear transformer driver module design

International Nuclear Information System (INIS)

Zhao Yue; Xie Weiping; Zhou Liangji; Chen Lin

2014-01-01

Linear Transformer Driver is a novel pulsed power technology, its main merits include a parallel LC discharge array and Inductive Voltage Adder. The parallel LC discharge array lowers the whole circuit equivalent inductance and the Inductive Voltage Adder unites the modules in series in order to create a high electric field grads, meanwhile, restricts the high voltage in a small space. The lower inductance in favor of LTD output a fast waveform and IVA confine high voltage in secondary cavity. In recently, some LTD-based pulsed power system has been development yet. The usual LTD architecture provides damped sine shaped output pulses that may not be suitable in flash radiography, high power microwave production, z-pinch drivers, and certain other applications. A more suitable driver output pulse would have a flat or inclined top (slightly rising or falling). In this paper, we present the design of an LTD cavity that generates this type of the output pulse by including within its circular array some number of the harmonic bricks in addition to the standard bricks according to Fourier progression theory. The parallel LC discharge array circuit formula is introduced by Kirchhoff Law, and the sum of harmonic is proofed as an analytic result, meanwhile, rationality of design is proved by simulation. Varying gas spark discharge dynamic resistance with harmonic order and switches jitter are analyzed. The results are as following: The more harmonic order is an approach to the ideal rectangular waveform, but lead to more system complexity. The capacity decreases as harmonic order increase, and gas spark discharge dynamic resistance rises with the capacity. The rising time protracts and flat is decay or even vanishes and the shot to shot reproducibility is degenerate as the switches jitter is high. (authors)

[Pulse-modulated Electromagnetic Radiation of Extremely High Frequencies Protects Cellular DNA against Damaging Effect of Physico-Chemical Factors in vitro].

Science.gov (United States)

Gapeyev, A B; Lukyanova, N A

2015-01-01

Using a comet assay technique, we investigated protective effects of. extremely high frequency electromagnetic radiation in combination with the damaging effect of X-ray irradiation, the effect of damaging agents hydrogen peroxide and methyl methanesulfonate on DNA in mouse whole blood leukocytes. It was shown that the preliminary exposure of the cells to low intensity pulse-modulated electromagnetic radiation (42.2 GHz, 0.1 mW/cm2, 20-min exposure, modulation frequencies of 1 and 16 Hz) caused protective effects decreasing the DNA damage by 20-45%. The efficacy of pulse-modulated electromagnetic radiation depended on the type of genotoxic agent and increased in a row methyl methanesulfonate--X-rays--hydrogen peroxide. Continuous electromagnetic radiation was ineffective. The mechanisms of protective effects may be connected with an induction of the adaptive response by nanomolar concentrations of reactive oxygen species formed by pulse-modulated electromagnetic radiation.

Yessotoxin as a Tool to Study Induction of Multiple Cell Death Pathways

Directory of Open Access Journals (Sweden)

Mónica Suárez Korsnes

2012-07-01

Full Text Available This work proposes to use the marine algal toxin yessotoxin (YTX to establish reference model experiments to explore medically valuable effects from induction of multiple cell death pathways. YTX is one of few toxins reported to make such induction. It is a small molecule compound which at low concentrations can induce apoptosis in primary cultures, many types of cells and cell lines. It can also induce a non-apoptotic form of programmed cell death in BC3H1 myoblast cell lines. The present contribution reviews arguments that this type of induction may have principal interest outside this particular example. One principal effect of medical interest may be that cancer cells will not so easily adapt to the synergistic effects from induction of more than one death pathway as compared to induction of only apoptosis.

Ultra-wide bandwidth improvement of piezoelectric energy harvesters through electrical inductance coupling

Science.gov (United States)

Abdelmoula, H.; Abdelkefi, A.

2015-11-01

The design and analysis of innovative ultra-wide bandwidth piezoelectric energy harvesters are deeply investigated. An electrical inductance is considered in the harvester's circuit to be connected in series or parallel to a load resistance. A lumped-parameter model is used to model the electromechanical response of the harvester when subjected to harmonic excitations. A linear comprehensive analysis is performed to investigate the effects of an electrical inductance on the coupled frequencies and damping of the harvester. It is shown that including an electrical inductance connected in series or in parallel to an electrical load resistance can result in the appearance of a second coupled frequency of electrical type. The results show that the inclusion of an inductance may give the opportunity to tune one of the coupled frequencies of mechanical and electrical types to the available excitation frequency in the environment. Using the gradient method, an optimization analysis is then performed to determine the optimum values of the electrical inductance and load resistance that maximize the harvested power. It is demonstrated that, for each excitation frequency, there is a combination of optimum values of the electrical inductance and resistance in such a way an optimum constant value of the harvested power is found. Numerical analysis is then performed to show the importance of considering an additional inductance in the harvester's circuitry in order to design broadband energy harvesters. The results show that the presence of the second coupled frequency of electrical type due to the inductance gives the possibility to design optimal broadband inductive-resistive piezoelectric energy harvesters with minimum displacement due to shunt damping effect.

Highly pathogenic avian influenza virus H5N1 controls type I IFN induction in chicken macrophage HD-11 cells: a polygenic trait that involves NS1 and the polymerase complex

Science.gov (United States)

2012-01-01

Background Influenza A viruses are well characterized to antagonize type I IFN induction in infected mammalian cells. However, limited information is available for avian cells. It was hypothesised that avian influenza viruses (AIV) with distinct virulence may interact differently with the avian innate immune system. Therefore, the type I IFN responses induced by highly virulent and low virulent H5N1 AIV and reassortants thereof were analysed in chicken cells. Results The highly pathogenic (HP) AIV A/chicken/Yamaguchi/7/04 (H5N1) (Yama) did not induce type I IFN in infected chicken HD-11 macrophage-like cells. This contrasted with an NS1 mutant Yama virus (Yama-NS1A144V) and with the attenuated H5N1 AIV A/duck/Hokkaido/Vac-1/04 (Vac) carrying the haemagglutinin (HA) of the Yama virus (Vac-Yama/HA), that both induced type I IFN in these cells. The substitution of the NS segment from Yama with that from Vac in the Yama backbone resulted in induction of type I IFN secretion in HD-11 cells. However, vice versa, the Yama NS segment did not prevent type I IFN induction by the Vac-Yama/HA virus. This was different with the PB1/PB2/PA segment reassortant Yama and Vac-Yama/HA viruses. Whereas the Yama virus with the Vac PB1/PB2/PA segments induced type I IFN in HD-11 cells, the Vac-Yama/HA virus with the Yama PB1/PB2/PA segments did not. As reported for mammalian cells, the expression of H5N1 PB2 inhibited the activation of the IFN-β promoter in chicken DF-1 fibroblast cells. Importantly, the Yama PB2 was more potent at inhibiting the IFN-β promoter than the Vac PB2. Conclusions The present study demonstrates that the NS1 protein and the polymerase complex of the HPAIV Yama act in concert to antagonize chicken type I IFN secretion in HD-11 cells. PB2 alone can also exert a partial inhibitory effect on type I IFN induction. In conclusion, the control of type I IFN induction by H5N1 HPAIV represents a complex phenotype that involves a particular viral gene constellation

The role of timing in the induction of neuromodulation in perceptual learning by transcranial electric stimulation.

Science.gov (United States)

Pirulli, Cornelia; Fertonani, Anna; Miniussi, Carlo

2013-07-01

Transcranial electric stimulation (tES) protocols are able to induce neuromodulation, offering important insights to focus and constrain theories of the relationship between brain and behavior. Previous studies have shown that different types of tES (i.e., direct current stimulation - tDCS, and random noise stimulation - tRNS) induce different facilitatory behavioral effects. However to date is not clear which is the optimal timing to apply tES in relation to the induction of robust facilitatory effects. The goal of this work was to investigate how different types of tES (tDCS and tRNS) can modulate behavioral performance in the healthy adult brain in relation to their timing of application. We applied tES protocols before (offline) or during (online) the execution of a visual perceptual learning (PL) task. PL is a form of implicit memory that is characterized by an improvement in sensory discrimination after repeated exposure to a particular type of stimulus and is considered a manifestation of neural plasticity. Our aim was to understand if the timing of tES is critical for the induction of differential neuromodulatory effects in the primary visual cortex (V1). We applied high-frequency tRNS, anodal tDCS and sham tDCS on V1 before or during the execution of an orientation discrimination task. The experimental design was between subjects and performance was measured in terms of d' values. The ideal timing of application varied depending on the stimulation type. tRNS facilitated task performance only when it was applied during task execution, whereas anodal tDCS induced a larger facilitation if it was applied before task execution. The main result of this study is the finding that the timing of identical tES protocols yields opposite effects on performance. These results provide important guidelines for designing neuromodulation induction protocols and highlight the different optimal timing of the two excitatory techniques. Copyright © 2013 Elsevier Inc. All

Dynamic Average-Value Modeling of Doubly-Fed Induction Generator Wind Energy Conversion Systems

Science.gov (United States)

Shahab, Azin

In a Doubly-fed Induction Generator (DFIG) wind energy conversion system, the rotor of a wound rotor induction generator is connected to the grid via a partial scale ac/ac power electronic converter which controls the rotor frequency and speed. In this research, detailed models of the DFIG wind energy conversion system with Sinusoidal Pulse-Width Modulation (SPWM) scheme and Optimal Pulse-Width Modulation (OPWM) scheme for the power electronic converter are developed in detail in PSCAD/EMTDC. As the computer simulation using the detailed models tends to be computationally extensive, time consuming and even sometimes not practical in terms of speed, two modified approaches (switching-function modeling and average-value modeling) are proposed to reduce the simulation execution time. The results demonstrate that the two proposed approaches reduce the simulation execution time while the simulation results remain close to those obtained using the detailed model simulation.

[Mood induction procedures: a critical review].

Science.gov (United States)

Gilet, A-L

2008-06-01

For a long period in the history of psychological research, emotion and cognition have been studied independently, as if one were irrelevant to the other. The renewed interest of researchers for the study of the relations between cognition and emotion has led to the development of a range of laboratory methods for inducing temporary mood states. This paper aims to review the main mood induction procedures allowing the induction of a negative mood as well as a positive mood, developed since the pioneer study of Schachter and Singer [Psychol Rev 69 (1962) 379-399] and to account for the usefulness and problems related to the use of such techniques. The first part of this paper deals with the detailed presentation of some of the most popular mood induction procedures according to their type: simple (use of only one mood induction technique) or combined (association of two or more techniques at once). The earliest of the modern techniques is the Velten Mood Induction Procedure [Behav Res Ther 6 (1968) 473-482], which involves reading aloud sixty self-referent statements progressing from relative neutral mood to negative mood or dysphoria. Some researchers have varied the procedure slightly by changing the number of the statements [Behav Res Ther 21 (1983) 233-239, Br J Clin Psychol 21 (1982) 111-117, J Pers Soc Psychol 35 (1977) 625-636]. Various other mood induction procedures have been developed including music induction [Cogn Emotion 11 (1997) 403-432, Br J Med Psychol 55 (1982) 127-138], film clip induction [J Pers Soc Psychol 20 (1971) 37-43, Cogn Emotion 7 (1993) 171-193, Rottenberg J, Ray RR, Gross JJ. Emotion elicitation using films. In: Coan JA, Allen JJB, editors. The handbook of emotion elicitation and assessment. New York: Oxford University Press, 2007], autobiographical recall [J Clin Psychol 36 (1980) 215-226, Jallais C. Effets des humeurs positives et négatives sur les structures de connaissances de type script. Thèse de doctorat non publi

Suggestibility and suggestive modulation of the Stroop effect.

Science.gov (United States)

Kirsch, Irving

2011-06-01

Although the induction of a hypnotic state does not seem necessary for suggestive modulation of the Stroop effect, this important phenomenon has seemed to be dependent on the subject's level of hypnotic suggestibility. Raz and Campbell's (2011) study indicates that suggestion can modulate the Stroop effect substantially in very low suggestible subjects, as well as in those who are highly suggestible. This finding casts doubt on the presumed mechanism by which suggestive modulation is brought about. Research aimed at uncovering the means by which low suggestible individuals are able to modulate the Stroop effect would be welcome, as would assessment of this effect in moderately suggestible people. Copyright © 2010 Elsevier Inc. All rights reserved.

Thio and hydrogen peroxide modofication of recA induction in UV-irradiated wild-type and catalase-deficient Escherichia coli K12

International Nuclear Information System (INIS)

Claycamp, H.G.; Kam-Kuen Ho; DeRose, C.; Iowa Univ., Iowa City, IA

1990-01-01

Induction of recA in Escherichia coli, monitored as β-D-galactosidase activity in recA-lacZ fusion strains, was shown to be elevated and prolonged by dithiothreitol (DTT) treatment after far-UV radiation. Pretreatment of UV-irradiated coltures using DTT led to a shortened recA response and little increase of β-Gal yield. Similar studies were performed using a catalase-deficient recA-lacZ strain in which the major feature was elevated levels of recA-lacZ induction. Catalase activity in UV-irradiated wild-type cells was reduced by DTT treatment to levels as low as in a katE mutant strain, leading to similar recA-lacZ induction patterns between the strains. Neither DTT nor H 2 O 2 treatment of cells could induce significant recA transcription in the absence of UV-radiation, implying that both agents modify recA activity primarily by interfering with repair of recA-inducing DNA lesions. The results confirm previous studies suggesting that modification of DNA repair is probably a significant portion of thiol radiation protection. (author). 36 refs.; 7 figs.; 1 tab

ULF Generation by Modulated Ionospheric Heating

Science.gov (United States)

Chang, C.; Labenski, J.; Wallace, T.; Papadopoulos, K.

2013-12-01

Modulated ionospheric heating experiments designed to generate ULF waves using the HAARP heater have been conducted since 2007. Artificial ULF waves in the Pc1 frequency range were observed from space and by ground induction magnetometers located in the vicinity of the heater as well as at long distances. Two distinct generation mechanisms of artificial ULF waves were identified. The first was electroject modulation under geomagnetically disturbed conditions. The second was pressure modulation in the E and F regions of the ionosphere under quiet conditions. Ground detections of ULF waves near the heater included both Shear Alfven waves and Magnetosonic waves generated by electrojet and/or pressure modulations. Distant ULF detections involved Magnetosonic wave propagation in the Alfvenic duct with pressure modulation as the most likely source. Summary of our observations and theoretical interpretations will be presented at the meeting. We would like to acknowledge the support provided by the staff at the HAARP facility during our ULF experiments.

Energy production estimation for Kosh-Agach grid-tie photovoltaic power plant for different photovoltaic module types

Science.gov (United States)

Gabderakhmanova, T. S.; Kiseleva, S. V.; Frid, S. E.; Tarasenko, A. B.

2016-11-01

This paper is devoted to calculation of yearly energy production, demanded area and capital costs for first Russian 5 MW grid-tie photovoltaic (PV) plant in Altay Republic that is named Kosh-Agach. Simple linear calculation model, involving average solar radiation and temperature data, grid-tie inverter power-efficiency dependence and PV modules parameters is proposed. Monthly and yearly energy production, equipment costs and demanded area for PV plant are estimated for mono-, polycrystalline and amorphous modules. Calculation includes three types of initial radiation and temperature data—average day for every month from NASA SSE, average radiation and temperature for each day of the year from NASA POWER and typical meteorology year generated from average data for every month. The peculiarities for each type of initial data and their influence on results are discussed.

Energy production estimation for Kosh-Agach grid-tie photovoltaic power plant for different photovoltaic module types

International Nuclear Information System (INIS)

Gabderakhmanova, T S; Frid, S E; Tarasenko, A B; Kiseleva, S V

2016-01-01

This paper is devoted to calculation of yearly energy production, demanded area and capital costs for first Russian 5 MW grid-tie photovoltaic (PV) plant in Altay Republic that is named Kosh-Agach. Simple linear calculation model, involving average solar radiation and temperature data, grid-tie inverter power-efficiency dependence and PV modules parameters is proposed. Monthly and yearly energy production, equipment costs and demanded area for PV plant are estimated for mono-, polycrystalline and amorphous modules. Calculation includes three types of initial radiation and temperature data—average day for every month from NASA SSE, average radiation and temperature for each day of the year from NASA POWER and typical meteorology year generated from average data for every month. The peculiarities for each type of initial data and their influence on results are discussed. (paper)

Finite Element Model for Thermal-Structural analysis of CLIC Lab Module type 0#2

CERN Document Server

Moilanen, Antti; Vamvakas, Alex; Vainola, Jukka Ilmari; Doebert, Steffen

2017-01-01

Temperature changes lead to unwanted thermo-mechanical deformations in the components of the Compact Linear Collider (CLIC) module. There are several sources and sinks of heat around the CLIC two-beam module. Heat is generated in the components that produce, transfer, and extract radio frequency (RF) power. Excess heat is removed from the components by cooling water as well as dissipated to air by convection from the outer surfaces of the components. The ambient temperature might also vary along the tunnel during the operation of CLIC. Due to tight assembling and alignment tolerances, it is necessary to minimize the thermo-mechanical deformations in the components. In this paper, the steps of thermal-structural Finite Element Analysis (FEA) of CLIC lab module type 0#2 are described from geometry model simplification to setting up the simulation. The description is accompanied by useful hints for CATIA and ANSYS users performing similar modelling tasks. A reliable computer simulation is important for studying ...

Conscious/Unconscious Dissociation Induction: Increasing Hypnotic Performance With "Resistant" Clients.

Science.gov (United States)

Lankton, Stephen

2016-10-01

Milton H. Erickson promoted several approaches to psychotherapy using hypnosis. In the last decades of his life, his work moved away from the use of redundant suggestion and a predominance of direct suggestion in favor of indirect suggestion. In addition, he frequently employed a type of storytelling (that has come to be called therapeutic metaphor) to indirectly convey learning. Another change that occurred during the last decade was his definition of the cause of a symptom. However, there were two important areas of his work that he did not change during his career. These two components of his work he did not change were his definition of a cure and the importance of a naturalistic induction. This article concerns his naturalistic approach to hypnotic induction and especially his use of conscious/unconscious dissociation in the induction process and how indirect suggestion and therapeutic binds can be used to facilitate that type of induction and a cure.

The light ion pulsed power induction accelerator for ETF

International Nuclear Information System (INIS)

Mazarakis, M.G.; Olson, R.E.; Olson, C.L.; Smith, D.L.; Bennett, L.F.

1994-01-01

Our Engineering Test Facility (ETF) driver concept is based on HERMES III and RHEPP technologies. Actually, it is a scaled-down version of the LMF design incorporating repetition rate capabilities of up to 10 Hz CW. The preconceptual design presented here provides 200-TW peak power to the ETF target during 10 ns, equal to 2-MJ total ion beam energy. Linear inductive voltage addition driving a self-magnetically insulated transmission line (MITL) is utilized to generate the 36-MV peak voltage needed for lithium ion beams. The ∼ 3-MA ion current is achieved by utilizing many accelerating modules in parallel. Since the current per module is relatively modest (∼300 kA), two-stage or one-stage extraction diodes can be utilized for the generation of singly charged lithium ions. The accelerating modules are arranged symmetrically around the fusion chamber in order to provide uniform irradiation onto the ETF target. In addition, the modules are fired in a programmed sequence in order to generate the optimum power pulse shape onto the target. This design utilizes RHEPP accelerator modules as the principal power source

The GARP/Latent TGF-β1 complex on Treg cells modulates the induction of peripherally derived Treg cells during oral tolerance.

Science.gov (United States)

Edwards, Justin P; Hand, Timothy W; Morais da Fonseca, Denise; Glass, Deborah D; Belkaid, Yasmine; Shevach, Ethan M

2016-06-01

Treg cells can secrete latent TGF-β1 (LTGF-β1), but can also utilize an alternative pathway for transport and expression of LTGF-β1 on the cell surface in which LTGF-β1 is coupled to a distinct LTGF-β binding protein termed glycoprotein A repetitions predominant (GARP)/LRRC32. The function of the GARP/LTGF-β1 complex has remained elusive. Here, we examine in vivo the roles of GARP and TGF-β1 in the induction of oral tolerance. When Foxp3(-) OT-II T cells were transferred to wild-type recipient mice followed by OVA feeding, the conversion of Foxp3(-) to Foxp3(+) OT-II cells was dependent on recipient Treg cells. Neutralization of IL-2 in the recipient mice also abrogated this conversion. The GARP/LTGF-β1 complex on recipient Treg cells, but not dendritic cell-derived TGF-β1, was required for efficient induction of Foxp3(+) T cells and for the suppression of delayed hypersensitivity. Expression of the integrin αvβ8 by Treg cells (or T cells) in the recipients was dispensable for induction of Foxp3 expression. Transient depletion of the bacterial flora enhanced the development of oral tolerance by expanding Treg cells with enhanced expression of the GARP/LTGF-β1 complex. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

Protein conservation and variation suggest mechanisms of cell type-specific modulation of signaling pathways.

Directory of Open Access Journals (Sweden)

Martin H Schaefer

2014-06-01

Full Text Available Many proteins and signaling pathways are present in most cell types and tissues and yet perform specialized functions. To elucidate mechanisms by which these ubiquitous pathways are modulated, we overlaid information about cross-cell line protein abundance and variability, and evolutionary conservation onto functional pathway components and topological layers in the pathway hierarchy. We found that the input (receptors and the output (transcription factors layers evolve more rapidly than proteins in the intermediary transmission layer. In contrast, protein expression variability decreases from the input to the output layer. We observed that the differences in protein variability between the input and transmission layer can be attributed to both the network position and the tendency of variable proteins to physically interact with constitutively expressed proteins. Differences in protein expression variability and conservation are also accompanied by the tendency of conserved and constitutively expressed proteins to acquire somatic mutations, while germline mutations tend to occur in cell type-specific proteins. Thus, conserved core proteins in the transmission layer could perform a fundamental role in most cell types and are therefore less tolerant to germline mutations. In summary, we propose that the core signal transmission machinery is largely modulated by a variable input layer through physical protein interactions. We hypothesize that the bow-tie organization of cellular signaling on the level of protein abundance variability contributes to the specificity of the signal response in different cell types.

Glycosylation of Candida albicans cell wall proteins is critical for induction of innate immune responses and apoptosis of epithelial cells.

Directory of Open Access Journals (Sweden)

Jeanette Wagener

Full Text Available C. albicans is one of the most common fungal pathogen of humans, causing local and superficial mucosal infections in immunocompromised individuals. Given that the key structure mediating host-C. albicans interactions is the fungal cell wall, we aimed to identify features of the cell wall inducing epithelial responses and be associated with fungal pathogenesis. We demonstrate here the importance of cell wall protein glycosylation in epithelial immune activation with a predominant role for the highly branched N-glycosylation residues. Moreover, these glycan moieties induce growth arrest and apoptosis of epithelial cells. Using an in vitro model of oral candidosis we demonstrate, that apoptosis induction by C. albicans wild-type occurs in early stage of infection and strongly depends on intact cell wall protein glycosylation. These novel findings demonstrate that glycosylation of the C. albicans cell wall proteins appears essential for modulation of epithelial immunity and apoptosis induction, both of which may promote fungal pathogenesis in vivo.

Design of a PC Based Pressure Indicator Using Inductive Pick-up Type Transducer and Bourdon Tube Sensor

Directory of Open Access Journals (Sweden)

S. C. BERA

2009-08-01

Full Text Available Bourdon tube is a mechanical type pressure sensor and the bourdon gauge measures gauge pressure of a process pipe line or a process tank. But it is a local indicator and special costlier techniques are required to transmit the reading of bourdon gauge to a remote distance. In the present paper, a very simple inductive pick-up type technique has been developed to transmit the reading of bourdon gauge to a remote distance in the form of 1-5 Volt D.C. signal. This signal has been optically isolated to design a PC based pressure indicator using Labtech Note Book Pro software. The theoretical analysis of the whole technique has been presented in the paper. The instrument developed using this technique has been experimentally tested and the experimental results are reported in the paper. A good linearity and repeatability of the instrument has been observed.

Cloud Atlas: Discovery of Rotational Spectral Modulations in a Low-mass, L-type Brown Dwarf Companion to a Star

Science.gov (United States)

Manjavacas, Elena; Apai, Dániel; Zhou, Yifan; Karalidi, Theodora; Lew, Ben W. P.; Schneider, Glenn; Cowan, Nicolas; Metchev, Stan; Miles-Páez, Paulo A.; Burgasser, Adam J.; Radigan, Jacqueline; Bedin, Luigi R.; Lowrance, Patrick J.; Marley, Mark S.

2018-01-01

Observations of rotational modulations of brown dwarfs and giant exoplanets allow the characterization of condensate cloud properties. As of now, rotational spectral modulations have only been seen in three L-type brown dwarfs. We report here the discovery of rotational spectral modulations in LP261-75B, an L6-type intermediate surface gravity companion to an M4.5 star. As a part of the Cloud Atlas Treasury program, we acquired time-resolved Wide Field Camera 3 grism spectroscopy (1.1–1.69 μm) of LP261-75B. We find gray spectral variations with the relative amplitude displaying only a weak wavelength dependence and no evidence for lower-amplitude modulations in the 1.4 μm water band than in the adjacent continuum. The likely rotational modulation period is 4.78 ± 0.95 hr, although the rotational phase is not well sampled. The minimum relative amplitude in the white light curve measured over the whole wavelength range is 2.41% ± 0.14%. We report an unusual light curve, which seems to have three peaks approximately evenly distributed in rotational phase. The spectral modulations suggests that the upper atmosphere cloud properties in LP261-75B are similar to two other mid-L dwarfs of typical infrared colors, but differ from that of the extremely red L-dwarf WISE0047.

Design of arc power supply for neutral beam injection system based on super capacitor energy storage

International Nuclear Information System (INIS)

Yang Puqiong; Xuan Weimin; Cao Jianyong; Li Qing; Liu Xiaolong

2015-01-01

The arc power supply is one of the most important equipment for neutral beam injection system. The stability of arc discharge and the quality of ion beam extraction were determined by its performance. For improving stability of the arc discharge, reducing the power network capacity and decreasing impulse on power network, the topology of the arc power supply applied the structure of DC/DC converter based on technology of super capacitor energy storage and switching power supply. Several IGBT power modules are operated in parallel, and it can improve the arc power supply's operating frequency and dynamic response. A filter circuit and a current fast transferring circuit were designed based on a detailed analysis on working process of the arc power sup- ply. According to the requirements and parameters of the arc power supply, and the current response of RL first order circuit, the minimum filter inductances were accurately calculated. Finally, using the model and Matlab, the performance of the arc power supply was simulated and verified, and it meets the design requirement. (authors)

Inductive reasoning.

Science.gov (United States)

Hayes, Brett K; Heit, Evan; Swendsen, Haruka

2010-03-01

Inductive reasoning entails using existing knowledge or observations to make predictions about novel cases. We review recent findings in research on category-based induction as well as theoretical models of these results, including similarity-based models, connectionist networks, an account based on relevance theory, Bayesian models, and other mathematical models. A number of touchstone empirical phenomena that involve taxonomic similarity are described. We also examine phenomena involving more complex background knowledge about premises and conclusions of inductive arguments and the properties referenced. Earlier models are shown to give a good account of similarity-based phenomena but not knowledge-based phenomena. Recent models that aim to account for both similarity-based and knowledge-based phenomena are reviewed and evaluated. Among the most important new directions in induction research are a focus on induction with uncertain premise categories, the modeling of the relationship between inductive and deductive reasoning, and examination of the neural substrates of induction. A common theme in both the well-established and emerging lines of induction research is the need to develop well-articulated and empirically testable formal models of induction. Copyright © 2010 John Wiley & Sons, Ltd. For further resources related to this article, please visit the WIREs website. Copyright © 2010 John Wiley & Sons, Ltd.

Capacitor Current Feedback-Based Active Resonance Damping Strategies for Digitally-Controlled Inductive-Capacitive-Inductive-Filtered Grid-Connected Inverters

DEFF Research Database (Denmark)

Lorzadeh, Iman; Askarian Abyaneh, Hossein; Savaghebi, Mehdi

2016-01-01

Inductive-capacitive-inductive (LCL)-type line filters are widely used in grid-connected voltage source inverters (VSIs), since they can provide substantially improved attenuation of switching harmonics in currents injected into the grid with lower cost, weight and power losses than their L......-type counterparts. However, the inclusion of third order LCL network complicates the current control design regarding the system stability issues because of an inherent resonance peak which appears in the open-loop transfer function of the inverter control system near the control stability boundary. To avoid...... passive (resistive) resonance damping solutions, due to their additional power losses, active damping (AD) techniques are often applied with proper control algorithms in order to damp the LCL filter resonance and stabilize the system. Among these techniques, the capacitor current feedback (CCF) AD has...

Induction melting of simulated transuranic waste

International Nuclear Information System (INIS)

Tenaglia, R.D.; McCall, J.L.

1983-06-01

Coreless induction melting was investigated as a method to melt and consolidate waste material representative of the transuranic waste (TRU) stored at the Idaho National Engineering Laboratory (INEL). Waste material was introduced onto the surface of a molten cast iron bath in a coreless induction furnace. Waste metallics were incorporated into the bath. Noncombustibles formed a slag which was poured or skimmed from the bath surface. Stack sampling was performed to characterize the off-gas and particulate matter evolved. Experimental melting tests were performed for a variety of types of wastes including metallics, chemical sludge, soil, concrete, and glass. Each test also included a representative level of combustible materials consisting of paper, wood, cloth, polyvinyl chloride and polyethylene. Metallic wastes were readily processed by induction melting with a minimum of slag production. Test waste consisting primarily of chemical sludge provided fluid slags which could be poured from the bath surface. Processing of wastes consisting of soil, concrete, or glass was limited by the inability to achieve fluid slags. It appears from test results that coreless induction melting is a feasible method to process INEL-type waste materials if two problems can be resolved. First, slag fluidity must be improved to facilitate the collection of slags formed from soil, concrete, or glass containing wastes. Secondly, refractory life must be further optimized to permit prolonged processing of the waste materials. The use of a chrome-bearing high-alumina refractory was found to resist slag line attach much better than a magnesia refractory, although some attack was still noted

Modulation of DNA damage response and induction of apoptosis mediates synergism between doxorubicin and a new imidazopyridine derivative in breast and lung cancer cells.

Science.gov (United States)

El-Awady, Raafat A; Semreen, Mohammad H; Saber-Ayad, Maha M; Cyprian, Farhan; Menon, Varsha; Al-Tel, Taleb H

2016-01-01

DNA damage response machinery (DDR) is an attractive target of cancer therapy. Modulation of DDR network may alter the response of cancer cells to DNA damaging anticancer drugs such as doxorubicin. The aim of the present study is to investigate the effects of a newly developed imidazopyridine (IAZP) derivative on the DDR after induction of DNA damage in cancer cells by doxorubicin. Cytotoxicity sulphrhodamine-B assay showed a weak anti-proliferative effect of IAZP alone on six cancer cell lines (MCF7, A549, A549DOX11, HepG2, HeLa and M8) and a normal fibroblast strain. Combination of IAZP with doxorubicin resulted in synergism in lung (A549) and breast (MCF7) cancer cells but neither in the other cancer cell lines nor in normal fibroblasts. Molecular studies revealed that synergism is mediated by modulation of DNA damage response and induction of apoptosis. Using constant-field gel electrophoresis and immunofluorescence detection of γ-H2AX foci, IAZP was shown to inhibit the repair of doxorubicin-induced DNA damage in A549 and MCF7 cells. Immunoblot analysis showed that IAZP suppresses the phosphorylation of the ataxia lelangiectasia and Rad3 related (ATR) protein, which is an important player in the response of cancer cells to chemotherapy-induced DNA damage. Moreover, IAZP augmented the doxorubicin-induced degradation of p21, activation of p53, CDK2, caspase 3/7 and phosphorylation of Rb protein. These effects enhanced doxorubicin-induced apoptosis in both cell lines. Our results indicate that IAZP is a promising agent that may enhance the cytotoxic effects of doxorubicin on some cancer cells through targeting the DDR. It is a preliminary step toward the clinical application of IAZP in combination with anticancer drugs and opens the avenue for the development of compounds targeting the DDR pathway that might improve the therapeutic index of anticancer drugs and enhance their cure rate. Copyright © 2015 Elsevier B.V. All rights reserved.

Sensitivity analysis for modules for various biosphere types

International Nuclear Information System (INIS)

Karlsson, Sara; Bergstroem, U.; Rosen, K.

2000-09-01

This study presents the results of a sensitivity analysis for the modules developed earlier for calculation of ecosystem specific dose conversion factors (EDFs). The report also includes a comparison between the probabilistically calculated mean values of the EDFs and values gained in deterministic calculations. An overview of the distribution of radionuclides between different environmental parts in the models is also presented. The radionuclides included in the study were 36 Cl, 59 Ni, 93 Mo, 129 I, 135 Cs, 237 Np and 239 Pu, sel to represent various behaviour in the biosphere and some are of particular importance from the dose point of view. The deterministic and probabilistic EDFs showed a good agreement, for most nuclides and modules. Exceptions from this occurred if very skew distributions were used for parameters of importance for the results. Only a minor amount of the released radionuclides were present in the model compartments for all modules, except for the agricultural land module. The differences between the radionuclides were not pronounced which indicates that nuclide specific parameters were of minor importance for the retention of radionuclides for the simulated time period of 10 000 years in those modules. The results from the agricultural land module showed a different pattern. Large amounts of the radionuclides were present in the solid fraction of the saturated soil zone. The high retention within this compartment makes the zone a potential source for future exposure. Differences between the nuclides due to element specific Kd-values could be seen. The amount of radionuclides present in the upper soil layer, which is the most critical zone for exposure to humans, was less then 1% for all studied radionuclides. The sensitivity analysis showed that the physical/chemical parameters were the most important in most modules in contrast to the dominance of biological parameters in the uncertainty analysis. The only exception was the well module where

Advanced Propulsion Power Distribution System for Next Generation Electric/Hybrid Vehicle. Phase 1; Preliminary System Studies

Science.gov (United States)

Bose, Bimal K.; Kim, Min-Huei

1995-01-01

The report essentially summarizes the work performed in order to satisfy the above project objective. In the beginning, different energy storage devices, such as battery, flywheel and ultra capacitor are reviewed and compared, establishing the superiority of the battery. Then, the possible power sources, such as IC engine, diesel engine, gas turbine and fuel cell are reviewed and compared, and the superiority of IC engine has been established. Different types of machines for drive motor/engine generator, such as induction machine, PM synchronous machine and switched reluctance machine are compared, and the induction machine is established as the superior candidate. Similar discussion was made for power converters and devices. The Insulated Gate Bipolar Transistor (IGBT) appears to be the most superior device although Mercury Cadmium Telluride (MCT) shows future promise. Different types of candidate distribution systems with the possible combinations of power and energy sources have been discussed and the most viable system consisting of battery, IC engine and induction machine has been identified. Then, HFAC system has been compared with the DC system establishing the superiority of the former. The detailed component sizing calculations of HFAC and DC systems reinforce the superiority of the former. A preliminary control strategy has been developed for the candidate HFAC system. Finally, modeling and simulation study have been made to validate the system performance. The study in the report demonstrates the superiority of HFAC distribution system for next generation electric/hybrid vehicle.

High power operation of the polyphase resonant converter modulator system for the spallation neutron source linear accelerator

CERN Document Server

Reass, W A; Baca, D M; Doss, J D; Gonzáles, J M; Gribble, R F; Trujillo, P G

2003-01-01

The spallation neutron source (SNS) is a new 1.4 MW average power beam, 1 GeV accelerator being built at Oak Ridge national laboratory. The accelerator requires 15 "long-pulse" converter-modulator stations each providing a maximum of 11 MW pulses with a 1.1 MW average power. Two variants of the converter-modulator are utilized, an 80 kV and a 140 kV design, the voltage dependant on the type of klystron load. The converter-modulator can be described as a resonant zero-voltage- switching polyphase boost inverter. As noted in Figure 1, each converter modulator derives its buss voltage from a standard 13.8 kV to 2100 Y (1.5 MVA) substation cast-core transformer. The substation also contains harmonic traps and filters to accommodate IEEE 519 and 141 regulations. Each substation is followed by an SCR preregulator to accommodate system voltage changes from no load to full load, in addition to providing a soft-start function. Energy storage and filtering is provided by special low inductance self-clearing metallized ...

Oral tolerance induction for human food allergy.

Science.gov (United States)

Noh, Geunwoong; Lee, Jae Ho

2012-04-01

Food allergies are classified as IgE-mediated and non-IgE mediated type. The number of successful reports of immunotherapy, namely tolerance induction for food allergy (TIFA) are increasing, bringing hope for meaningful positive and radical treatment of food allergy. Therapeutic characteristics of the clinical course in TIFA for NFA are different from TIFA for IFA. Cytokines including IL-10, TGF-β and IFN-γ and regulatory cells such as Treg and Breg, are involved in immune tolerance. IFN-γ has been used for tolerance induction of food allergy as an immunomodulatory biologics. A definitive distinction between IgE-mediated and non-IgE-mediated food allergies is absolutely essential for diagnostic and therapeutic purposes. Original SOTI using IFN-γ is more effective then conventional SOTI without IFN-γ. Especially, IFN-γ is absolutely necessary for the tolerance induction of NFA. This review highlights and updates the advances in the conceptual immunological background and the clinical characteristics of oral tolerance induction for food allergy.

Antibody induction versus corticosteroid induction for liver transplant recipients

DEFF Research Database (Denmark)

Penninga, Luit; Wettergren, André; Wilson, Colin H

2014-01-01

BACKGROUND: Liver transplantation is an established treatment option for end-stage liver failure. To date, no consensus has been reached on the use of immunosuppressive T-cell specific antibody induction compared with corticosteroid induction of immunosuppression after liver transplantation....... OBJECTIVES: To assess the benefits and harms of T-cell specific antibody induction versus corticosteroid induction for prevention of acute rejection in liver transplant recipients. SEARCH METHODS: We searched The Cochrane Hepato-Biliary Group Controlled Trials Register, the Cochrane Central Register...... to identify additional trials. SELECTION CRITERIA: We included all randomised clinical trials assessing immunosuppression with T-cell specific antibody induction versus corticosteroid induction in liver transplant recipients. Our inclusion criteria stated that participants within each included trial should...

Five-Level Current-Source Inverters With Buck–Boost and Inductive-Current Balancing Capabilities

DEFF Research Database (Denmark)

Gao, Feng; Loh, Poh Chiang; Blaabjerg, Frede

2010-01-01

This paper presents new five-level current-source inverters (CSIs) with voltage/current buck–boost capability, unlike existing five-level CSIs where only voltage–boost operation is supported. The proposed inverters attain self-inductive-currentbalancing per switching cycle at their dc front ends...... without having to include additional balancing hardware or complex control manipulation. The inverters can conveniently be controlled by using the well-established phase-shifted carrier modulation scheme with only two additional linear references and a mapping logic table needed. Existing modulators can...

Inductance and resistance measurement method for vessel detection and coil powering in all-surface inductive heating systems composed of outer squircle coils

Science.gov (United States)

Kilic, Veli Tayfun; Unal, Emre; Demir, Hilmi Volkan

2017-05-01

In this work, we investigate a method proposed for vessel detection and coil powering in an all-surface inductive heating system composed of outer squircle coils. Besides conventional circular coils, coils with different shapes such as outer squircle coils are used for and enable efficient all-surface inductive heating. Validity of the method, which relies on measuring inductance and resistance values of a loaded coil at different frequencies, is experimentally demonstrated for a coil with shape different from conventional circular coil. Simple setup was constructed with a small coil to model an all-surface inductive heating system. Inductance and resistance maps were generated by measuring coil's inductance and resistance values at different frequencies loaded by a plate made of different materials and located at various positions. Results show that in an induction hob for various coil geometries it is possible to detect a vessel's presence, to identify its material type and to specify its position on the hob surface by considering inductance and resistance of the coil measured on at least two different frequencies. The studied method is important in terms of enabling safe, efficient and user flexible heating in an all-surface inductive heating system by automatically detecting the vessel's presence and powering on only the coils that are loaded by the vessel with predetermined current levels.

Theoretical analysis of a YBCO squirrel-cage type induction motor based on an equivalent circuit

International Nuclear Information System (INIS)

Morita, G; Nakamura, T; Muta, I

2006-01-01

A HTS induction motor, with a HTS squirrel-cage rotor, is analysed using an electrical equivalent circuit. The squirrel-cage winding in the rotor consists of rotor bars and end rings, and both are considered to be made of YBCO film conductors. A wide range of electric field versus current density in YBCO film is formulated based on the Weibull function, and analysed as a non-linear resistance in the equivalent circuit. It is shown that starting and accelerating torques of the HTS induction motor are improved drastically compared to those of a conventional induction motor. Furthermore, large synchronous torque can also be realized by trapping the magnetic flux in the rotor circuit because of the persistent current mode

Differential Involvement of Left Prefrontal Cortexin Inductive and Deductive Reasoning

Science.gov (United States)

Goel, Vinod; Dolan, Raymond J.

2004-01-01

While inductive and deductive reasoning are considered distinct logical and psychological processes, little is known about their respective neural basis. To address this issue we scanned 16 subjects with fMRI, using an event-related design, while they engaged in inductive and deductive reasoning tasks. Both types of reasoning were characterized by…

High energy, low inductance, high current fiberglass energy storage capacitor for the Atlas Machine Marx modules