An overview on "cellular cannibalism" with special reference to oral squamous cell carcinoma.

Science.gov (United States)

Jain, M

2015-12-01

Cellular cannibalism has been defined as a large cell engulfing a slightly smaller one within its cytoplasm. It has been described in various cancers like bladder cancer, breast cancer, lung cancer, gastric cancer, oral squamous cell carcinoma. Cellular cannibalism has been well correlated with anaplasia, tumor aggressiveness, grading and metastatic potential. Present review focuses on significance of cannibalism in relation to cancer with special emphasis on oral squamous cell carcinoma.

The Development of M Cells in Peyer’s Patches Is Restricted to Specialized Dome-Associated Crypts

Science.gov (United States)

Gebert, Andreas; Fassbender, Susanne; Werner, Kerstin; Weissferdt, Annikka

1999-01-01

It is controversial whether the membranous (M) cells of the Peyer’s patches represent a separate cell line or develop from enterocytes under the influence of lymphocytes on the domes. To answer this question, the crypts that produce the dome epithelial cells were studied and the distribution of M cells over the domes was determined in mice. The Ulex europaeus agglutinin was used to detect M cells in mouse Peyer’s patches. Confocal microscopy with lectin-gold labeling on ultrathin sections, scanning electron microscopy, and laminin immuno-histochemistry were combined to characterize the cellular composition and the structure of the dome-associated crypts and the dome epithelium. In addition, the sites of lymphocyte invasion into the dome epithelium were studied after removal of the epithelium using scanning electron microscopy. The domes of Peyer’s patches were supplied with epithelial cells that derived from two types of crypt: specialized dome-associated crypts and ordinary crypts differing not only in shape, size, and cellular composition but also in the presence of M cell precursors. When epithelial cells derived from ordinary crypts entered the domes, they formed converging radial strips devoid of M cells. In contrast to the M cells, the sites where lymphocytes invaded the dome epithelium were not arranged in radial strips, but randomly distributed over the domes. M cell development is restricted to specialized dome-associated crypts. Only dome epithelial cells that derive from these specialized crypts differentiate into M cells. It is concluded that M cells represent a separate cell line that is induced in the dome-associated crypts by still unknown, probably diffusible lymphoid factors. PMID:10329609

Strategic alliance, a way forward for violence against women: a case for the Special Cells, India.

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Dave, Anjali

2013-10-01

This article attempts to describe the experiences of violated women and the struggles of social workers to contest violence against women in the Indian context. It begins with a brief account of an "indigenous model": the establishment of a service for violated women in India within the police force--the Special Cell on Violence Against Women. The article traces the strategic location, vision, growth, present position, expansion, and replication of the Special Cell in India, and discusses the necessity of working simultaneously with violated women, formal systems, and social structures; its contribution to the campaign for a Domestic Violence Act; and the resultant outcomes. The arduous nature of the work required for violated women and the women's own assessment of the Special Cells were accessed through a rigorous evaluation study, which is presented in the article, providing an answer and affirmation to the question: Why work with the Establishment--the State.

Special AT rich-binding1 protein (SATB1) in malignant T cells

DEFF Research Database (Denmark)

Fredholm, Simon; Willerslev-Olsen, Andreas; Met, Özcan

2018-01-01

Deficient expression of Suppressor Special AT-rich Binding-1 (SATB1) hampers thymocyte development and results in inept T cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides (MF), the most frequent variant of cutaneous T cell lymphoma (CTCL......) whereas increased SATB1 expression had the opposite effect indicating that the mir-155 target SATB1 is a repressor of IL-5 and IL-9 in malignant T cells. In accordance, inhibition of STAT5, and its upstream activator Janus Kinase-3 (Jak3), triggered increased SATB1 expression and a concomitant suppression...

A special issue on reviews in biomedical applications of nanomaterials, tissue engineering, stem cells, bioimaging, and toxicity.

Science.gov (United States)

Nalwa, Hari Singh

2014-10-01

This second special issue of the Journal of Biomedical Nanotechnology in a series contains another 30 state-of-the-art reviews focused on the biomedical applications of nanomaterials, biosensors, bone tissue engineering, MRI and bioimaging, single-cell detection, stem cells, endothelial progenitor cells, toxicity and biosafety of nanodrugs, nanoparticle-based new therapeutic approaches for cancer, hepatic and cardiovascular disease.

Odontoblasts: Specialized hard-tissue-forming cells in the dentin-pulp complex.

Science.gov (United States)

Kawashima, Nobuyuki; Okiji, Takashi

2016-07-01

Odontoblasts are specialized cells that produce dentin and exhibit unique morphological characteristics; i.e., they extend cytoplasmic processes into dentinal tubules. While osteoblasts, which are typical hard-tissue-forming cells, are generated from mesenchymal stem cells during normal and pathological bone metabolism, the induction of odontoblasts only occurs once during tooth development, and odontoblasts survive throughout the lives of healthy teeth. During the differentiation of odontoblasts, signaling molecules from the inner enamel epithelium are considered necessary for the differentiation of odontoblast precursors, i.e., peripheral dental papilla cells. If odontoblasts are destroyed by severe external stimuli, such as deep caries, the differentiation of dental pulp stem cells into odontoblast-like cells is induced. Various bioactive molecules, such as non-collagenous proteins, might be involved in this process, although the precise mechanisms responsible for odontoblast differentiation have not been fully elucidated. Recently, our knowledge about the other functional activities of odontoblasts (apart from dentin formation) has increased. For example, it has been suggested that odontoblasts might act as nociceptive receptors, and surveillance cells that detect the invasion of exogenous pathogens. The regeneration of the dentin-pulp complex has recently gained much attention as a promising future treatment modality that could increase the longevity of pulpless teeth. Finally, congenital dentin anomalies, which are concerned with the disturbance of odontoblast functions, are summarized. © 2016 Japanese Teratology Society.

Special tests and destructive physical analyses as used by the Aerospace Corporation with nickel-hydrogen cells

Science.gov (United States)

Zimmerman, A. H.; Quinzio, M. V.; Thaller, L. H.

1992-01-01

The destructive physical analysis (DPA) of electrochemical devices is an important part of the overall test. Specific tests were developed to investigate the degradation mode or the failure mechanism that surfaces during the course of a cell being assembled, acceptance tested, and life-cycle tested. The tests that have been developed are peculiar to the cell chemistry under investigation. Tests are often developed by an individual or group of researchers as a result of their particular interest in an unresolved failure mechanism or degradation mode. A series of production, operational, and storage issues that were addressed by the Electrochemistry Group at The Aerospace Corporation are addressed. As a result of these investigations, as well as associated research studies carried out to develop a clearer understanding of the nickel oxyhydroxide electrode, a series of unique and useful specialized tests were developed. Some of these special tests were assembled to describe the methods that were found to be particularly useful in resolving a wide spectrum of manufacturing, operational, and storage issues related to nickel-hydrogen cells. The general methodology of these tests is given here with references listed to provide the reader with a more detailed understanding of the tests. The tests are classified according to the sequencing, starting with the impregnation of the nickel plaque material and culminating with the storage of completed cells. The details of the wet chemical procedures that were found to be useful because of their accuracy and reproducibility are given. The equations used to make the appropriate calculations are listed.

Distinct Functions of Specialized Dendritic Cell Subsets in Atherosclerosis and the Road Ahead

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Alma Zernecke

2014-01-01

Full Text Available Atherosclerotic vascular disease is modulated by immune mechanisms. Dendritic cells (DCs and T cells are present within atherosclerotic lesions and function as central players in the initiation and modulation of adaptive immune responses. In previous years, we have studied the functional contribution of distinct DC subsets in disease development, namely, that of CCL17-expressing DCs as well as that of plasmacytoid DCs that play specialized roles in disease development. This review focuses on important findings gathered in these studies and dissects the multifaceted contribution of CCL17-expressing DCs and pDCs to the pathogenesis of atherosclerosis. Furthermore, an outlook on future challenges faced when studying DCs in this detrimental disease are provided, and hurdles that will need to be overcome in order to enable a better understanding of the contribution of DCs to atherogenesis are discussed, a prerequisite for their therapeutic targeting in atherosclerosis.

Special proliferative sites are not needed for seeding and proliferation of transfused bone marrow cells in normal syngeneic mice

International Nuclear Information System (INIS)

Brecher, G.; Ansell, J.D.; Micklem, H.S.; Tjio, J.H.; Cronkite, E.P.

1982-01-01

The widely held view that transfused bone marrow cells will not proliferate in normal mice, not exposed to irradiation or other forms of bone marrow ablation, was reinvestigated. Forty million bone marrow cells from male donors were given to female recipients on each of 5 consecutive days, 5 to 10 times the number customarily used in the past. When the recipients were examined 2-13 weeks after the last transfusion, donor cells were found to average 16-25% of total marrow cells. Similar percentages of donor cells were found when variants of the enzyme phosphoglycerate kinase determined electrophoretically were used for identification of donor and recipient cells. Evidence is presented that the proportion of donor cells is compatible with a nonlinear dependence on the number of cells transfused over the range tested - i.e., 20-200 million bone marrow cells injected intravenously. Special proliferative sites thus do not appear to be required

The special cell effects and somatic consequences of exposure to low dose radiation

International Nuclear Information System (INIS)

Regina Fedortseva; Sergei Aleksanin; Eugene Zheleznyakov; Irina Bychkovskaya

2007-01-01

Complete text of publication follows. Objective: The experimental data presented in the report put some clarity into the ongoing polemics about possibility of induction of harmful non-carcinogenic effects in human body as a result of exposure to low doses of radiation. The denial of this possibility is based on the fact that traditionally studied genotoxic effects cannot be the cause of this pathology: the incidence of these effects in exposure to low doses of radiation is fairly low; the effects are not overt in critical slowly regenerating tissues, since they can only be morphologically manifested in actively growing cell populations. Methods: Endothelium of myocardial and alveolar capillaries were studied ultra-structurally in 236 rats irradiated by a wide range of X-ray doses (0,25;0,5;2,25;4,5;9;30;48;100) and 28 intact control animals. Studies were conducted during 12-18 months. The material consisted of 2-3 portions from various parts of myocardium and lung. From each portion, sections were prepared, in which all capillary sections were analyzed and ultra-structure of all lining capillary endotheliocytes (their number most often was more than 100) was studied. In each animal the percentage of non-viable endotheliocytes with signs of generalized organoid destruction, damage of plasmalemma and nuclear structures was accounted. Results: Irradiation of rat to low and higher doses caused significant (up to 7 times) increase number of endothelial cells with various ultra-structural damages (from relatively light ones to in the cell death). Even the lowest dose - 0,25 Gy produce an increasing degeneration, intracellular lysis and defects of mitochondria. We found unusual features of postradiational endothelium changes: dose independence, necessity of revealing the long-term, non-mutational cellular effects, massive involvement of cells, early development of the maximum effect already after the low dose irradiation. These special somatic effects, unlike genotoxic

Probing the mystery of Chinese medicine meridian channels with special emphasis on the connective tissue interstitial fluid system, mechanotransduction, cells durotaxis and mast cell degranulation

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Fung Peter

2009-05-01

Full Text Available Abstract This article hypothesizes that the Chinese medicine meridian system is a special channel network comprising of skin with abundant nerves and nociceptive receptors of various types, and deeper connective tissues inside the body with the flowing interstitial fluid system. These meridian channels provide efficient migratory tracks mainly due to durotaxis (also including chemotaxis for mast cells, fibroblasts and other cells to migrate and carry out a number of physiological functions. Acupuncture acting on meridian channel causes cytoskeletal remodeling through mechanotransduction, leading to regulation of gene expression and the subsequent production of related proteins. Also, stimulation on cell surface can trigger Ca2+ activities, resulting in a cascade of intra- and inter-cellular signaling. Moreover, nerve endings in the meridian channels interact with mast cells and induce the degranulation of these cells, leading to the release of many specific biomolecules needed for homeostasis, immune surveillance, wound healing and tissue repair. Acupoint along a meridian channel is a functional site to trigger the above functions with specificity and high efficiency.

Special issue photovoltaic

International Nuclear Information System (INIS)

2004-01-01

In this letter of the INES (french National Institute of the Solar Energy), a special interest is given to photovoltaic realizations in Europe. Many information are provided on different topics: the China future fifth world producer of cells in 2005, batteries and hydrogen to storage the solar energy and a technical sheet on a photovoltaic autonomous site installation for electric power production. (A.L.B.)

Comparative anatomy of leaves of Kalanchoe pinnata and K. crenata in sun and shade conditions, as a support for their identification

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Nattacha S. Moreira

2012-04-01

Full Text Available Kalanchoe pinnata (Lam. Pers. and K. crenata (Andrews Haw., Crassulaceae, are popularly used in the treatment of many diseases. Their biological activities, such as anti-leishmaniasis and analgesic, can be useful in phytotherapy. Both species are often misidentified as the other, because of their similar popular uses and names, and the similar external morphology of the leaves. We investigated the existence of anatomical characters that will permit correct identification of the species grown in shade and in sun conditions. We also contribute with new observations on the leaf anatomy of K. pinnata and K. crenata. Fixed (FAA70 leaves were used, and their sections were embedded in Leica historesin. Hydathodes were observed in both species, and for the first time were anatomically described in K. crenata. The species showed anatomical differences in relation to the presence of epidermal idioblasts only in K. crenata, the different pattern of distribution of subepidermal idioblasts, and the presence of leaf buds only in K. pinnata.

Comparative anatomy of leaves of Kalanchoe pinnata and K. crenata in sun and shade conditions, as a support for their identification

Directory of Open Access Journals (Sweden)

Nattacha S. Moreira

2012-10-01

Full Text Available Kalanchoe pinnata (Lam. Pers. and K. crenata (Andrews Haw., Crassulaceae, are popularly used in the treatment of many diseases. Their biological activities, such as anti-leishmaniasis and analgesic, can be useful in phytotherapy. Both species are often misidentified as the other, because of their similar popular uses and names, and the similar external morphology of the leaves. We investigated the existence of anatomical characters that will permit correct identification of the species grown in shade and in sun conditions. We also contribute with new observations on the leaf anatomy of K. pinnata and K. crenata. Fixed (FAA70 leaves were used, and their sections were embedded in Leica historesin. Hydathodes were observed in both species, and for the first time were anatomically described in K. crenata. The species showed anatomical differences in relation to the presence of epidermal idioblasts only in K. crenata, the different pattern of distribution of subepidermal idioblasts, and the presence of leaf buds only in K. pinnata.

X-ray and proton induced ultrastructural changes in Chlamydomonas reinhardi, with special reference to the dividing cell

International Nuclear Information System (INIS)

Gruber, H.E.

1976-01-01

Liquid cultures were exposed to 9000 R x-irradiation delivered at approximately 600 R/min. This produced 69 percent mortality in the 137c wild type strain and 71 percent mortality in the acetate-requiring strain ac-31. Irradiated and control cells were fixed for electron microscopic examination at intervals up to five days post exposure. Proton-irradiations using a positive ion Van de Graff accelerator were administered to monolayers of cells attached to Millipore filters. Irradiated and control cells were later resuspended and incubated in liquid culture medium. The dose rate was approximately 20 kilorad/second for thin targets with the dose monitored with a solid state detector. Distinctive fine structural responses were observed for the two kinds of radiation at the indicated exposure levels. Alterations affecting the nucleus were prominent after x-irradiation. Nuclei were observed in which non-nucleolar condensations and swollen nuclear envelopes were evident. Nuclear envelope rupture was noted when cells were in an advanced state of disorganization. Multiple nuclei per cell were also observed. Proton-irradiation often resulted in both live and dead daughter cells within the same mother cell wall. Changes in the chloroplast and mitochondria were seen after both types of irradiation. Two features absent in control cells were of special interest. Following x- and proton-irradiation, cells were observed which remained joined in configurations closely resembling division profiles or division conformations. Irradiated cells also possessed chromosomes and spindle fibers at a time not characteristic for such events in control cells

Efficient K+ buffering by mammalian retinal glial cells is due to cooperation of specialized ion channels.

Science.gov (United States)

Nilius, B; Reichenbach, A

1988-06-01

Radial glial (Müller) cells were isolated from rabbit retinae by papaine and mechanical dissociation. Regional membrane properties of these cells were studied by using the patch-clamp technique. In the course of our experiments, we found three distinct types of large K+ conducting channels. The vitread process membrane was dominated by high conductance inwardly rectifying (HCR) channels which carried, in the open state, inward currents along a conductance of about 105 pS (symmetrical solutions with 140 mM K+) but almost no outward currents. In the membrane of the soma and the proximal distal process, we found low conductance inwardly rectifying (LCR) channels which had an open state-conductance of about 60 pS and showed rather weak rectification. The endfoot membrane, on the other hand, was found to contain non-rectifying very high conductance (VHC) channels with an open state-conductance of about 360 pS (same solutions). These results suggest that mammalian Müller cells express regional membrane specializations which are optimized to carry spatial buffering currents of excess K+ ions.

Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells.

Science.gov (United States)

Manda, Katrin; Glasow, Annegret; Paape, Daniel; Hildebrandt, Guido

2012-01-01

Dendritic cells (DCs), as professional antigen-presenting cells, are members of the innate immune system and function as key players during the induction phase of adaptive immune responses. Uptake, processing, and presentation of antigens direct the outcome toward either tolerance or immunity. The cells of the immune system are among the most highly radiosensitive cells in the body. For high doses of ionizing radiation (HD-IR) both immune-suppressive effects after whole body irradiation and possible immune activation during tumor therapy were observed. On the other hand, the effects of low doses of ionizing radiation (LD-IR) on the immune system are controversial and seem to show high variability among different individuals and species. There are reports revealing that protracted LD-IR can result in radioresistance. But immune-suppressive effects of chronic LD-IR are also reported, including the killing or sensitizing of certain cell types. This article shall review the current knowledge of radiation-induced effects on the immune system, paying special attention to the interaction of DCs and T cells.

Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells

International Nuclear Information System (INIS)

Manda, Katrin; Glasow, Annegret; Paape, Daniel; Hildebrandt, Guido

2012-01-01

Dendritic cells (DCs), as professional antigen-presenting cells, are members of the innate immune system and function as key players during the induction phase of adaptive immune responses. Uptake, processing, and presentation of antigens direct the outcome toward either tolerance or immunity. The cells of the immune system are among the most highly radiosensitive cells in the body. For high doses of ionizing radiation (HD-IR) both immune-suppressive effects after whole body irradiation and possible immune activation during tumor therapy were observed. On the other hand, the effects of low doses of ionizing radiation (LD-IR) on the immune system are controversial and seem to show high variability among different individuals and species. There are reports revealing that protracted LD-IR can result in radioresistance. But immune-suppressive effects of chronic LD-IR are also reported, including the killing or sensitizing of certain cell types. This article shall review the current knowledge of radiation-induced effects on the immune system, paying special attention to the interaction of DCs and T cells.

Effects of ionizing radiation on the immune system with special emphasis on the interaction of dendritic and T cells

Energy Technology Data Exchange (ETDEWEB)

Manda, Katrin [Department of Radiotherapy and Radiation Oncology, University of Rostock, Rostock (Germany); Glasow, Annegret [Department of Radiotherapy and Radiation Oncology, University of Leipzig, Leipzig (Germany); Paape, Daniel; Hildebrandt, Guido, E-mail: guido.hildebrandt@uni-rostock.de [Department of Radiotherapy and Radiation Oncology, University of Rostock, Rostock (Germany)

2012-08-24

Dendritic cells (DCs), as professional antigen-presenting cells, are members of the innate immune system and function as key players during the induction phase of adaptive immune responses. Uptake, processing, and presentation of antigens direct the outcome toward either tolerance or immunity. The cells of the immune system are among the most highly radiosensitive cells in the body. For high doses of ionizing radiation (HD-IR) both immune-suppressive effects after whole body irradiation and possible immune activation during tumor therapy were observed. On the other hand, the effects of low doses of ionizing radiation (LD-IR) on the immune system are controversial and seem to show high variability among different individuals and species. There are reports revealing that protracted LD-IR can result in radioresistance. But immune-suppressive effects of chronic LD-IR are also reported, including the killing or sensitizing of certain cell types. This article shall review the current knowledge of radiation-induced effects on the immune system, paying special attention to the interaction of DCs and T cells.

Osteoclast cell-surface specializations and nuclear kinetics during egg-laying in Japanese quail

International Nuclear Information System (INIS)

Miller, S.C.

1981-01-01

Medullary bone deposits serve as a reservoir of labile calcium for egg-shell calcification in birds. Quantitative transmission-electron-microscope methods and light-microscope autoradiographic cell-population-kinetic analyses were used to determine changes in cell-surface specializations and population dynamics of medullary bone osteoclasts during egg-laying in Japanese quail. Prior to egg-shell formation, from 0 to about 8 hours after the previous oviposition, very few osteoclast profiles had ruffled borders. The appearance of ruffled borders coincided with the beginning of egg-shell calcification, about 9-10 hours after the previous oviposition. During egg-shell calcification, about 10-21 hours after the previous oviposition, most osteoclast profiles had ruffled borders. Ruffled borders disappeared at the completion of egg-shell calcification and commencement of egg-shell pigmentation. Thus, functional activities of medullary bone osteoclasts appear to be closely synchronized with egg-shell calcification during egg-laying. From 1 to 48 hours after a single injection of 3H-thymidine (3H-TdR), very few labeled osteoclast nuclei were seen during egg-laying. Following multiple injections of 3H-TdR, the percentage of labeled nuclei reached a peak at about 170 hours after the first injection. At this peak-labeling time, relatively few of the osteoclast profiles that had labeled nuclei had two or more; although the average number of nuclei per osteoclast profile was about 3.6. These kinetic data suggest that the medullary bone osteoclast population has a prolonged rate of turnover compared to rapid changes in cell activities associated with each 24-hour egg-laying cycle; and collectively they would suggest that rapid changes in osteoclast functions occur independently of changes in cell-population dynamics

Leaf structural adaptations of two Limonium miller (Plumbaginales, Plumbaginaceae taxa

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Zorić Lana N.

2013-01-01

Full Text Available Limonium gmelinii (Willd. O. Kuntze 1891 subsp. hungaricum (Klokov Soó is Pannonian endemic subspecies that inhabits continental halobiomes, while Limonium anfractum (Salmon Salmon 1924 is one of the indicators of halophyte vegetation of marine rocks and its distribution is restricted to the southern parts of Mediterranean Sea coast. In this work, micromorphological and anatomical characters of leaves of these two Limonium taxa were analyzed, in order to examine their adaptations to specific environmental conditions on saline habitats. The results showed that both taxa exhibited strong xeromorphic adaptations that reflected in flat cell walls of epidermal cells, thick cuticle, high palisade/spongy tissue ratio, high index of palisade cells, the presence of sclereid idioblasts in leaf mesophyll and mechanical tissue by phloem and xylem. Both taxa are crynohalophytes and have salt glands on adaxial and abaxial epidermis for excretion of surplus salt. Relatively high dimensions of mesophyll cells, absence of non-glandular hairs and unprotected stomata slightly increased above the level of epidermal cells, are also adaptations to increased salinity. [Projekat Ministarstva nauke Republike Srbije, br. 173002

Special regulatory T-cell review: T-cell dependent suppression revisited.

Science.gov (United States)

Basten, Antony; Fazekas de St Groth, Barbara

2008-01-01

The concept of T-cell dependent regulation of immune responses has been a central tenet of immunological thinking since the delineation of the two cell system in the 1960s. Indeed T-cell dependent suppression was discovered before MHC restriction. When reviewing the data from the original wave of suppression, it is intriguing to reflect not just on the decline and fall of suppressor T cells in the 1980s, but on their equally dramatic return to respectability over the past decade. Hopefully their resurgence will be supported by solid mechanistic data that will underpin their central place in our current and future understanding of the immune system. Cannon to right of them, Cannon to left of them, Cannon in front of them Volley'd and thunder'd Storm'd at with shot and shell, Boldly they rode and well, Into the jaws of Death, Into the mouth of Hell, Rode the six hundred (suppressionists). (Adapted from The Charge of the Light Brigade, Alfred, Lord Tennyson)

Geomembrane special study

International Nuclear Information System (INIS)

1988-07-01

The objective of the Geomembrane Special Study was to asses the suitability of geomembranes in Uranium Mill Tailings Remedial Action (UMTRA) Project pile designs. Geomembranes, also called flexible membrane liners, are made of polymer resins and are thermoplastic materials. Part of the special study was to evaluate regulatory compliance and acceptability issues. This study was proposed because of the extensive use of geomembranes in hazardous waste site remedial actions and their accepted use in Resource Conservation and Recovery Act (RCRA) cells as both covers and liners to limit infiltration, or as part of leachate collection systems. This study has reviewed the recent geomembrane literature focusing on: (1) longevity; (2) performance; (3) constructibility; and (4) quality control/quality assurance considerations. In addition to these technical considerations, regulatory compliance and acceptability concerns were also evaluated. This report describes the results of the literature review, including correspondence with manufacturers, resin producers, experts in the field, and long-term major users. 12 refs., 2 tabs

Leaf histochemistry analysis of four medicinal species from Cerrado

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Vinícius C. Kuster

Full Text Available ABSTRACT Chemical components act in plant defense and protection, but many of them are extracted and used medicinally. For Cerrado, active chemical components are used in the treatment of diseases, which strengthens the necessity for pharmacological studies of plants of that environment. The objective was to evaluate the histochemistry of the leaf blade of Byrsonima verbascifolia (L. DC., Malpighiaceae, Campomanesia adamantium (Cambess. O.Berg, Myrtaceae, Roupala montana Aubl., Proteaceae, and Solanum lycocarpum A. St.-Hil., Solanaceae, species that have been reported as producers of secondary metabolites for pharmacological use. The 3rd node leaves (median, intercostal and margin regions were collected, fixed, included in Paraplast® or 2-hydroxyethyl methacrylate, sectioned in microtome, stained and photographed on microscope. This analysis aimed to find leaf regions which produced chemical compounds. For histochemical tests, intercostal areas were selected from median region leaf of the 3rd node. Samples fresh and newly collected and fixed and embedded in Paraplast® were used. Tests were conducted for lipids, terpenoids, phenolic compounds, alkaloids, sugars and proteins. Alkaloids were observed only in R. montana, as well as the results for phenolic compounds. Flavonoids are present in B. verbascifolia and R. montana. The lipid composition was showed for the chemical compounds of B. verbascifolia and C. adamantium, which proved to be part of the essential oils or resins oils in C. adamantium idioblasts. The chemical compounds of B. verbascifolia, C. adamantium and R. montana are present mainly in idioblasts among the parenchyma and epidermal cells. C. adamantium has secretory cavities, but only with lipid content. The identification of chemical compounds has not been possible in mature leaves of S. lycocarpum.

Evidence of two distinct functionally specialized fibroblast lineages in breast stroma

DEFF Research Database (Denmark)

Morsing, Mikkel; Klitgaard, Marie Christine; Jafari Kermani, Abbas

2016-01-01

Background The terminal duct lobular unit (TDLU) is the most dynamic structure in the human breast and the putative site of origin of human breast cancer. Although stromal cells contribute to a specialized microenvironment in many organs, this component remains largely understudied in the human...... conditions followed by analysis of adipogenic and osteogenic differentiation. To test whether the two fibroblast lineages are functionally imprinted by their site of origin, single cell sorted CD271low/MUC1high normal breast luminal epithelial cells are plated on fibroblast feeders for the observation...... fibroblast lineages exist in the normal human breast, of which the lobular fibroblasts have properties in common with mesenchymal stem cells and support epithelial growth and morphogenesis. We propose that lobular fibroblasts constitute a specialized microenvironment for human breast luminal epithelial...

Prophylactic role of melatonin against radiation induced damage in mouse cerebellum with special reference to Purkinje cells

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Sisodia, Rashmi; Kumari, Seema; Verma, Rajesh Kumar; Bhatia, A L [Neurobiology Laboratory, Department of Zoology, University of Rajasthan, Jaipur 302004 (India)

2006-06-15

Melatonin, a hormone with a proven antioxidative efficacy, crosses all morphophysiological barriers, including the blood-brain barrier, and distributes throughout the cell. The present study is an attempt to investigate the prophylactic influence of a chronic low level of melatonin against an acute radiation induced oxidative stress in the cerebellum of Swiss albino mice, with special reference to Purkinje cells. After 15 days of treatment the mice were sacrificed at various intervals from 1 to 30 days. Biochemical parameters included lipid peroxidation (LPO) and glutathione (GSH) levels as the endpoints. The quantitative study included alterations in number and volume of Purkinje cells. Swiss albino mice were orally administered a very low dose of melatonin (0.25 mg/mouse/day) for 15 consecutive days before single exposure to 4 Gy gamma radiation. Melatonin checked the augmented levels of LPO, by approximately 55%, by day 30 day post-exposure. Radiation induced depleted levels of GSH could be raised by 68.9% by day 30 post-exposure. Radiation exposure resulted in a reduction of the volume of Purkinje cells and their total number. The administration of melatonin significantly protected against the radiation induced decreases in Purkinje cell volume and number. Results indicate the antioxidative properties of melatonin resulting in its prophylactic property against radiation induced biochemical and cellular alterations in the cerebellum. The findings support the idea that melatonin may be used as an anti-irradiation drug due to its potent free radical scavenging and antioxidative efficacy.

Modelling zirconium hydrides using the special quasirandom structure approach

KAUST Repository

Wang, Hao; Chroneos, Alexander I.; Jiang, Chao; Schwingenschlö gl, Udo

2013-01-01

The study of the structure and properties of zirconium hydrides is important for understanding the embrittlement of zirconium alloys used as cladding in light water nuclear reactors. Simulation of the defect processes is complicated due to the random distribution of the hydrogen atoms. We propose the use of the special quasirandom structure approach as a computationally efficient way to describe this random distribution. We have generated six special quasirandom structure cells based on face centered cubic and face centered tetragonal unit cells to describe ZrH2-x (x = 0.25-0.5). Using density functional theory calculations we investigate the mechanical properties, stability, and electronic structure of the alloys. © the Owner Societies 2013.

"NeuroStem Chip": a novel highly specialized tool to study neural differentiation pathways in human stem cells

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Li Jia-Yi

2007-02-01

Full Text Available Abstract Background Human stem cells are viewed as a possible source of neurons for a cell-based therapy of neurodegenerative disorders, such as Parkinson's disease. Several protocols that generate different types of neurons from human stem cells (hSCs have been developed. Nevertheless, the cellular mechanisms that underlie the development of neurons in vitro as they are subjected to the specific differentiation protocols are often poorly understood. Results We have designed a focused DNA (oligonucleotide-based large-scale microarray platform (named "NeuroStem Chip" and used it to study gene expression patterns in hSCs as they differentiate into neurons. We have selected genes that are relevant to cells (i being stem cells, (ii becoming neurons, and (iii being neurons. The NeuroStem Chip has over 1,300 pre-selected gene targets and multiple controls spotted in quadruplicates (~46,000 spots total. In this study, we present the NeuroStem Chip in detail and describe the special advantages it offers to the fields of experimental neurology and stem cell biology. To illustrate the utility of NeuroStem Chip platform, we have characterized an undifferentiated population of pluripotent human embryonic stem cells (hESCs, cell line SA02. In addition, we have performed a comparative gene expression analysis of those cells versus a heterogeneous population of hESC-derived cells committed towards neuronal/dopaminergic differentiation pathway by co-culturing with PA6 stromal cells for 16 days and containing a few tyrosine hydroxylase-positive dopaminergic neurons. Conclusion We characterized the gene expression profiles of undifferentiated and dopaminergic lineage-committed hESC-derived cells using a highly focused custom microarray platform (NeuroStem Chip that can become an important research tool in human stem cell biology. We propose that the areas of application for NeuroStem microarray platform could be the following: (i characterization of the

Specialization Patterns

DEFF Research Database (Denmark)

Schultz, Ulrik Pagh; Lawall, Julia Laetitia; Consel, Charles

2000-01-01

Design patterns offer many advantages for software development, but can introduce inefficiency into the final program. Program specialization can eliminate such overheads, but is most effective when targeted by the user to specific bottlenecks. Consequently, we propose that these concepts...... are complementary. Program specialization can optimize programs written using design patterns, and design patterns provide information about the program structure that can guide specialization. Concretely, we propose specialization patterns, which describe how to apply program specialization to optimize uses...... of design patterns. In this paper, we analyze the specialization opportunities provided by specific uses of design patterns. Based on the analysis of each design pattern, we define the associated specialization pattern. These specialization opportunities can be declared using the specialization classes...

Existence of CD8α-like dendritic cells with a conserved functional specialization and a common molecular signature in distant mammalian species.

Science.gov (United States)

Contreras, Vanessa; Urien, Céline; Guiton, Rachel; Alexandre, Yannick; Vu Manh, Thien-Phong; Andrieu, Thibault; Crozat, Karine; Jouneau, Luc; Bertho, Nicolas; Epardaud, Mathieu; Hope, Jayne; Savina, Ariel; Amigorena, Sebastian; Bonneau, Michel; Dalod, Marc; Schwartz-Cornil, Isabelle

2010-09-15

The mouse lymphoid organ-resident CD8alpha(+) dendritic cell (DC) subset is specialized in Ag presentation to CD8(+) T cells. Recent evidence shows that mouse nonlymphoid tissue CD103(+) DCs and human blood DC Ag 3(+) DCs share similarities with CD8alpha(+) DCs. We address here whether the organization of DC subsets is conserved across mammals in terms of gene expression signatures, phenotypic characteristics, and functional specialization, independently of the tissue of origin. We study the DC subsets that migrate from the skin in the ovine species that, like all domestic animals, belongs to the Laurasiatheria, a distinct phylogenetic clade from the supraprimates (human/mouse). We demonstrate that the minor sheep CD26(+) skin lymph DC subset shares significant transcriptomic similarities with mouse CD8alpha(+) and human blood DC Ag 3(+) DCs. This allowed the identification of a common set of phenotypic characteristics for CD8alpha-like DCs in the three mammalian species (i.e., SIRP(lo), CADM1(hi), CLEC9A(hi), CD205(hi), XCR1(hi)). Compared to CD26(-) DCs, the sheep CD26(+) DCs show 1) potent stimulation of allogeneic naive CD8(+) T cells with high selective induction of the Ifngamma and Il22 genes; 2) dominant efficacy in activating specific CD8(+) T cells against exogenous soluble Ag; and 3) selective expression of functional pathways associated with high capacity for Ag cross-presentation. Our results unravel a unifying definition of the CD8alpha(+)-like DCs across mammalian species and identify molecular candidates that could be used for the design of vaccines applying to mammals in general.

Efficient oxygen electrocatalysis on special active sites

DEFF Research Database (Denmark)

Halck, Niels Bendtsen

throughout this thesis to understand these local structure effects and their influence on surface reactions. The concept of these special active sites is used to explain how oxygen evolution reaction (OER) catalysts can have activities beyond the limits of what was previously thought possible. The concept...... stored in these bonds in an eco-friendly fashion in fuel cells. This thesis explores catalysts for oxygen electrocatalysis and how carefully designed local structures on catalysts surfaces termed special active sites can influence the activity. Density functional theory has been used as a method...... is used to explain the increase in activity observed for the OER catalyst ruthenium dioxide when it is mixed with nickel or cobalt. Manganese and cobalt oxides when in the vicinity of gold also display an increase in OER activity which can be explained by locally created special active sites. Density...

Payment and Care for Hematopoietic Cell Transplantation Patients: Toward a Specialized Medical Home for Complex Care Patients.

Science.gov (United States)

Gajewski, James L; McClellan, Mark B; Majhail, Navneet S; Hari, Parameswaran N; Bredeson, Christopher N; Maziarz, Richard T; LeMaistre, Charles F; Lill, Michael C; Farnia, Stephanie H; Komanduri, Krishna V; Boo, Michael J

2018-01-01

Patient-centered medical home models are fundamental to the advanced alternative payment models defined in the Medicare Access and Children's Health Insurance Plan Reauthorization Act (MACRA). The patient-centered medical home is a model of healthcare delivery supported by alternative payment mechanisms and designed to promote coordinated medical care that is simultaneously patient-centric and population-oriented. This transformative care model requires shifting reimbursement to include a per-patient payment intended to cover services not previously reimbursed such as disease management over time. Payment is linked to quality measures, including proportion of care delivered according to predefined pathways and demonstrated impact on outcomes. Some medical homes also include opportunities for shared savings by reducing overall costs of care. Recent proposals have suggested expanding the medical home model to specialized populations with complex needs because primary care teams may not have the facilities or the requisite expertise for their unique needs. An example of a successful care model that may provide valuable lessons for those creating specialty medical home models already exists in many hematopoietic cell transplantation (HCT) centers that deliver multidisciplinary, coordinated, and highly specialized care. The integration of care delivery in HCT centers has been driven by the specialty care their patients require and by the payment methodology preferred by the commercial payers, which has included bundling of both inpatient and outpatient care in the peritransplant interval. Commercial payers identify qualified HCT centers based on accreditation status and comparative performance, enabled in part by center-level comparative performance data available within a national outcomes database mandated by the Stem Cell Therapeutic and Research Act of 2005. Standardization across centers has been facilitated via voluntary accreditation implemented by Foundation for

Individual specialization to non-optimal hosts in a polyphagous marine invertebrate herbivore.

Directory of Open Access Journals (Sweden)

Finn A Baumgartner

Full Text Available Factors determining the degree of dietary generalism versus specialism are central in ecology. Species that are generalists at the population level may in fact be composed of specialized individuals. The optimal diet theory assumes that individuals choose diets that maximize fitness, and individual specialization may occur if individuals' ability to locate, recognize, and handle different food types differ. We investigate if individuals of the marine herbivorous slug Elysia viridis, which co-occur at different densities on several green macroalgal species in the field, are specialized to different algal hosts. Individual slugs were collected from three original algal host species (Cladophora sericea, Cladophora rupestris and Codium fragile in the field, and short-term habitat choice and consumption, as well as long-term growth (proxy for fitness, on four algal diet species (the original algal host species and Chaetomorpha melagonium were studied in laboratory experiments. Nutritional (protein, nitrogen, and carbon content and morphological (dry weight, and cell/utricle volume algal traits were also measured to investigate if they correlated with the growth value of the different algal diets. E. viridis individuals tended to choose and consume algal species that were similar to their original algal host. Long-term growth of E. viridis, however, was mostly independent of original algal host, as all individuals reached a larger size on the non-host C. melagonium. E. viridis growth was positively correlated to algal cell/utricle volume but not to any of the other measured algal traits. Because E. viridis feeds by piercing individual algal cells, the results indicate that slugs may receive more cytoplasm, and thus more energy per unit time, on algal species with large cells/utricles. We conclude that E. viridis individuals are specialized on different hosts, but host choice in natural E. viridis populations is not determined by the energetic value of

Program specialization

CERN Document Server

Marlet, Renaud

2013-01-01

This book presents the principles and techniques of program specialization - a general method to make programs faster (and possibly smaller) when some inputs can be known in advance. As an illustration, it describes the architecture of Tempo, an offline program specializer for C that can also specialize code at runtime, and provides figures for concrete applications in various domains. Technical details address issues related to program analysis precision, value reification, incomplete program specialization, strategies to exploit specialized program, incremental specialization, and data speci

[Cultivation of a permanent fish cell line in serum-free media special experiences with a cytotoxicity test for waste water samples

Science.gov (United States)

Kohlpoth, Martin; Rusche, Brigitte

1997-01-01

The use of fetal calf serum (FCS) as standard medium additive for the cell cultivation must be regarded critically from the point of view of animal welfare as well as for scientific reasons and makes it necessary to look for alternatives. In the last years an in vitro cytotoxicity assay for the testing of industrial waste waters with the permanent fish cell line RTG-2 was established and pre-validated as an alternative to the fish test with the golden orfe. The application of FCS is also a special problem with regard to the testing of waste waters in a cytotoxicity test so that FCS-alternatives were tested. The RTG-2 cells were successfully adapted to the two solvents Basal Medium Supplement (BMS) and Ultroser-G (U-G) that are used to replace serum. The characterisation of these adapted cell lines showed no significant differences in growth rate, adhesion rate, viability and sensitivity to chemicals in comparison to the original RTG-2 cells. On the determination of the cytotoxicity of industrial waste waters the RTG-2 cells adapted to the BMS medium indicated a clearly higher toxicity of the waste water samples than the original RTG-2 cells. This result confirms the thesis that serum components react with waste water elements and thus change the bio-availability of toxic compounds.

Bioprocessing automation in cell therapy manufacturing: Outcomes of special interest group automation workshop.

Science.gov (United States)

Ball, Oliver; Robinson, Sarah; Bure, Kim; Brindley, David A; Mccall, David

2018-04-01

Phacilitate held a Special Interest Group workshop event in Edinburgh, UK, in May 2017. The event brought together leading stakeholders in the cell therapy bioprocessing field to identify present and future challenges and propose potential solutions to automation in cell therapy bioprocessing. Here, we review and summarize discussions from the event. Deep biological understanding of a product, its mechanism of action and indication pathogenesis underpin many factors relating to bioprocessing and automation. To fully exploit the opportunities of bioprocess automation, therapeutics developers must closely consider whether an automation strategy is applicable, how to design an 'automatable' bioprocess and how to implement process modifications with minimal disruption. Major decisions around bioprocess automation strategy should involve all relevant stakeholders; communication between technical and business strategy decision-makers is of particular importance. Developers should leverage automation to implement in-process testing, in turn applicable to process optimization, quality assurance (QA)/ quality control (QC), batch failure control, adaptive manufacturing and regulatory demands, but a lack of precedent and technical opportunities can complicate such efforts. Sparse standardization across product characterization, hardware components and software platforms is perceived to complicate efforts to implement automation. The use of advanced algorithmic approaches such as machine learning may have application to bioprocess and supply chain optimization. Automation can substantially de-risk the wider supply chain, including tracking and traceability, cryopreservation and thawing and logistics. The regulatory implications of automation are currently unclear because few hardware options exist and novel solutions require case-by-case validation, but automation can present attractive regulatory incentives. Copyright © 2018 International Society for Cellular Therapy

Specialized mouse embryonic stem cells for studying vascular development.

Science.gov (United States)

Glaser, Drew E; Burns, Andrew B; Hatano, Rachel; Medrzycki, Magdalena; Fan, Yuhong; McCloskey, Kara E

2014-01-01

Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood. Here, we report the generation of the first dual reporter mouse embryonic stem cell (mESC) lines designed to facilitate the study of vascular endothelial and smooth muscle development in vitro. These mESC lines express green fluorescent protein (GFP) under the endothelial promoter, Tie-2, and Discomsoma sp. red fluorescent protein (RFP) under the promoter for alpha-smooth muscle actin (α-SMA). The lines were then characterized for morphology, marker expression, and pluripotency. The mESC colonies were found to exhibit dome-shaped morphology, alkaline phosphotase activity, as well as expression of Oct 3/4 and stage-specific embryonic antigen-1. The mESC colonies were also found to display normal karyotypes and are able to generate cells from all three germ layers, verifying pluripotency. Tissue staining confirmed the coexpression of VE (vascular endothelial)-cadherin with the Tie-2 GFP+ expression on endothelial structures and smooth muscle myosin heavy chain with the α-SMA RFP+ smooth muscle cells. Lastly, it was verified that the developing mESC do express Tie-2 GFP+ and α-SMA RFP+ cells during differentiation and that the GFP+ cells colocalize with the vascular-like structures surrounded by α-SMA-RFP cells. These dual reporter vascular-specific mESC permit visualization and cell tracking of individual endothelial and smooth muscle cells over time and in multiple dimensions, a powerful new tool for studying vascular development in real time.

Preface to the SPECIAL ISSUE: Excitonic Solar Cells(II)

Institute of Scientific and Technical Information of China (English)

Jianjun Tian; Meicheng Li; Kaibo Zheng

2016-01-01

Among all the excitonic solar cells(ESCs)including dyesensitized solar cells(DSSCs),quantum solar cells(QDSCs),perovskites solar cells(PSCs),and organic photovoltaics(OPVs),PSCs attracted enormous research attention in the past 7 years and attained the highest power conversion efficiency(PCE)of over 20%with the biggest progress,from 3.8%to over 22.1%in 7 years.However,one can easily realize the fact that such a rapid progress achieved in PSCs was made possible is largely based on the fundamental knowledge,experimental skills,and characterization facilities obtained and accumulated through the multi-decade long endeavor in the study of other excitonic solar cells.Even though PSCs have attractedmuch research human resource and funding,the study on other excitonic solar cells has never stopped,and such persistent efforts

Comparative Leaf Anatomy of Gaiadendron punctatum and Tripodanthus belmirensis (Loranthaceae

Directory of Open Access Journals (Sweden)

Isabel Carmona Gallego

2018-01-01

Full Text Available Leaf anatomy of Gaiadendron punctatum and Tripodanthus belmirensis species is described with the aim of exploring possible characters that allow a precise identification of these two genera, characterized by tree or shrub habit, belonging to Loranthaceae family. Samples were processed and stained with routine techniques for observation on optical microscope. Both species showed similarities, such as one-layered epidermis and rubiaceous type stomata. However, a different anatomic composition was observed in aspects such as: mesophyll, position and shape of epidermic cells and presence of suber accumulations in G. punctatum, or numerous idioblasts in T. belmirensis. A dichotomous key was constructed for species determination based on anatomical leaf characters, between the species of genus Tripodanthus and G. punctatum. Furthermore, the use of anatomical characters in determination and support of distinguishable taxonomical entities inside Loranthaceae is also briefly discussed.

Specialized science.

Science.gov (United States)

Casadevall, Arturo; Fang, Ferric C

2014-04-01

As the body of scientific knowledge in a discipline increases, there is pressure for specialization. Fields spawn subfields that then become entities in themselves that promote further specialization. The process by which scientists join specialized groups has remarkable similarities to the guild system of the middle ages. The advantages of specialization of science include efficiency, the establishment of normative standards, and the potential for greater rigor in experimental research. However, specialization also carries risks of monopoly, monotony, and isolation. The current tendency to judge scientific work by the impact factor of the journal in which it is published may have roots in overspecialization, as scientists are less able to critically evaluate work outside their field than before. Scientists in particular define themselves through group identity and adopt practices that conform to the expectations and dynamics of such groups. As part of our continuing analysis of issues confronting contemporary science, we analyze the emergence and consequences of specialization in science, with a particular emphasis on microbiology, a field highly vulnerable to balkanization along microbial phylogenetic boundaries, and suggest that specialization carries significant costs. We propose measures to mitigate the detrimental effects of scientific specialism.

Design and operation of the National Survey of Children with Special Health Care Needs, 2009-2010.

Science.gov (United States)

Bramlett, Matthew D; Blumberg, Stephen J; Ormson, A Elizabeth; George, Jacquelyn M; Williams, Kim L; Frasier, Alicia M; Skalland, Benjamin J; Santos, Kathleen B; Vsetecka, Danielle M; Morrison, Heather M; Pedlow, Steven; Wang, Fang

2014-11-01

This report presents the development, plan, and operation of the 2009-2010 National Survey of Children with Special Health Care Needs, a module of the State and Local Area Integrated Telephone Survey. The survey is conducted by the Centers for Disease Control and Prevention's National Center for Health Statistics. This survey was designed to produce national and state-specific prevalence estimates of children with special health care needs (CSHCN), to describe the types of services that they need and use, and to assess aspects of the system of care for CSHCN. A random-digit-dial sample of households with children under age 18 years was constructed for each of the 50 states and the District of Columbia. The sampling frame consisted of landline phone numbers and cellular(cell) phone numbers of households that reported a cell-phone-only or cell-phone-mainly status. Children in identified households were screened for special health care needs. If CSHCN were identified in the household, a detailed interview was conducted for one randomly selected child with special health care needs. Respondents were parents or guardians who knew about the children's health and health care. A total of 196,159 household screening interviews were completed from July 2009 through March 2011, resulting in 40,242 completed special-needs interviews, including 2,991 from cell-phone interviews. The weighted overall response rate was 43.7% for the landline sample, 15.2% for the cell-phone sample, and 25.5% overall. All material appearing in this report is in the public domain and may be reproduced or copied without permission; citation as to source, however, is appreciated.

c-Yes regulates cell adhesion at the apical ectoplasmic specialization-blood-testis barrier axis via its effects on protein recruitment and distribution

Science.gov (United States)

Xiao, Xiang; Mruk, Dolores D.

2013-01-01

During spermatogenesis, extensive restructuring takes place at the cell-cell interface since developing germ cells migrate progressively from the basal to the adluminal compartment of the seminiferous epithelium. Since germ cells per se are not motile cells, their movement relies almost exclusively on the Sertoli cell. Nonetheless, extensive exchanges in signaling take place between these cells in the seminiferous epithelium. c-Yes, a nonreceptor protein tyrosine kinase belonging to the Src family kinases (SFKs) and a crucial signaling protein, was recently shown to be upregulated at the Sertoli cell-cell interface at the blood-testis barrier (BTB) at stages VIII–IX of the seminiferous epithelial cycle of spermatogenesis. It was also highly expressed at the Sertoli cell-spermatid interface known as apical ectoplasmic specialization (apical ES) at stage V to early stage VIII of the epithelial cycle during spermiogenesis. Herein, it was shown that the knockdown of c-Yes by RNAi in vitro and in vivo affected both Sertoli cell adhesion at the BTB and spermatid adhesion at the apical ES, causing a disruption of the Sertoli cell tight junction-permeability barrier function, germ cell loss from the seminiferous epithelium, and also a loss of spermatid polarity. These effects were shown to be mediated by changes in distribution and/or localization of adhesion proteins at the BTB (e.g., occludin, N-cadherin) and at the apical ES (e.g., nectin-3) and possibly the result of changes in the underlying actin filaments at the BTB and the apical ES. These findings implicate that c-Yes is a likely target of male contraceptive research. PMID:23169788

75 FR 57859 - Specially Adapted Housing and Special Home Adaptation

Science.gov (United States)

2010-09-23

... Home Adaptation AGENCY: Department of Veterans Affairs. ACTION: Final rule. SUMMARY: The Department of... specially adapted housing and special home adaptation grants. This final rule incorporates certain... regulations pertaining to eligibility for specially adapted housing (SAH) grants and special home adaptation...

Preface for Special Topic: Perovskite solar cells—A research update

Directory of Open Access Journals (Sweden)

Lukas Schmidt-Mende

2016-09-01

Full Text Available Over the last few years, tremendous progress has been made in the research field of perovskite solar cells. Not only are record power conversion efficiencies now exceeding 20%, but our understanding about the different mechanisms leading to this extraordinary performance has improved phenomenally. The aim of this special issue is to review the current state-of-the-art understanding of perovskite solar cells. Most of the presented articles are research updates giving a succinct overview over different aspects concerning perovskite solar cells.

Blood on the tracks: hematopoietic stem cell-endothelial cell interactions in homing and engraftment.

Science.gov (United States)

Perlin, Julie R; Sporrij, Audrey; Zon, Leonard I

2017-08-01

Cells of the hematopoietic system undergo rapid turnover. Each day, humans require the production of about one hundred billion new blood cells for proper function. Hematopoietic stem cells (HSCs) are rare cells that reside in specialized niches and are required throughout life to produce specific progenitor cells that will replenish all blood lineages. There is, however, an incomplete understanding of the molecular and physical properties that regulate HSC migration, homing, engraftment, and maintenance in the niche. Endothelial cells (ECs) are intimately associated with HSCs throughout the life of the stem cell, from the specialized endothelial cells that give rise to HSCs, to the perivascular niche endothelial cells that regulate HSC homeostasis. Recent studies have dissected the unique molecular and physical properties of the endothelial cells in the HSC vascular niche and their role in HSC biology, which may be manipulated to enhance hematopoietic stem cell transplantation therapies.

Special geometry

International Nuclear Information System (INIS)

Strominger, A.

1990-01-01

A special manifold is an allowed target manifold for the vector multiplets of D=4, N=2 supergravity. These manifolds are of interest for string theory because the moduli spaces of Calabi-Yau threefolds and c=9, (2,2) conformal field theories are special. Previous work has given a local, coordinate-dependent characterization of special geometry. A global description of special geometries is given herein, and their properties are studied. A special manifold M of complex dimension n is characterized by the existence of a holomorphic Sp(2n+2,R)xGL(1,C) vector bundle over M with a nowhere-vanishing holomorphic section Ω. The Kaehler potential on M is the logarithm of the Sp(2n+2,R) invariant norm of Ω. (orig.)

Glial Cells: The Other Cells of the Nervous System

Indian Academy of Sciences (India)

nervous system. The present .... In the vertebrate nervous system, special types of cells called radial glia .... As men- tioned earlier, astrocytes extend a 'foot process' (Figure 3) that ... capillaries that for a long time it was thought that these cells.

77 FR 2437 - Special Conditions: Gulfstream Aerospace Corporation, Model GVI Airplane; Rechargeable Lithium...

Science.gov (United States)

2012-01-18

... delivery of the affected aircraft. In addition, the substance of these special conditions has been subject... Ni-Cd and lead-acid cells, some types of lithium-battery cells use flammable liquid electrolytes. The... lithium batteries. The flammable-fluid fire-protection requirements of Sec. 25.863. In the past, this rule...

A Stromal Cell Niche for Human and Mouse Type 3 Innate Lymphoid Cells.

Science.gov (United States)

Hoorweg, Kerim; Narang, Priyanka; Li, Zhi; Thuery, Anne; Papazian, Natalie; Withers, David R; Coles, Mark C; Cupedo, Tom

2015-11-01

Adaptive immunity critically depends on the functional compartmentalization of secondary lymphoid organs. Mesenchymal stromal cells create and maintain specialized niches that support survival, activation, and expansion of T and B cells, and integrated analysis of lymphocytes and their niche has been instrumental in understanding adaptive immunity. Lymphoid organs are also home to type 3 innate lymphoid cells (ILC3), innate effector cells essential for barrier immunity. However, a specialized stromal niche for ILC3 has not been identified. A novel lineage-tracing approach now identifies a subset of murine fetal lymphoid tissue organizer cells that gives rise exclusively to adult marginal reticular cells. Moreover, both cell types are conserved from mice to humans and colocalize with ILC3 in secondary lymphoid tissues throughout life. In sum, we provide evidence that fetal stromal organizers give rise to adult marginal reticular cells and form a dedicated stromal niche for innate ILC3 in adaptive lymphoid organs. Copyright © 2015 by The American Association of Immunologists, Inc.

Plastic solar cells : understanding the special additive

NARCIS (Netherlands)

van Franeker, H.; Janssen, R.A.J.

2015-01-01

Solar cells use freely available sunlight to make electricity. At the present time, solar electricity does not come cheap, because solar panels are rather expensive. Now imagine that we could reduce costs by printing solar panels like we print newspapers! We can do just that with plastic solar

Specialization can drive the evolution of modularity.

Directory of Open Access Journals (Sweden)

Carlos Espinosa-Soto

2010-03-01

Full Text Available Organismal development and many cell biological processes are organized in a modular fashion, where regulatory molecules form groups with many interactions within a group and few interactions between groups. Thus, the activity of elements within a module depends little on elements outside of it. Modularity facilitates the production of heritable variation and of evolutionary innovations. There is no consensus on how modularity might evolve, especially for modules in development. We show that modularity can increase in gene regulatory networks as a byproduct of specialization in gene activity. Such specialization occurs after gene regulatory networks are selected to produce new gene activity patterns that appear in a specific body structure or under a specific environmental condition. Modules that arise after specialization in gene activity comprise genes that show concerted changes in gene activities. This and other observations suggest that modularity evolves because it decreases interference between different groups of genes. Our work can explain the appearance and maintenance of modularity through a mechanism that is not contingent on environmental change. We also show how modularity can facilitate co-option, the utilization of existing gene activity to build new gene activity patterns, a frequent feature of evolutionary innovations.

Specialization Patterns

OpenAIRE

Schultz , Ulrik Pagh; Lawall , Julia ,; Consel , Charles

1999-01-01

Design patterns offer numerous advantages for software development, but can introduce inefficiency into the finished program. Program specialization can eliminate such overheads, but is most effective when targeted by the user to specific bottlenecks. Consequently, we propose to consider program specialization and design patterns as complementary concepts. On the one hand, program specialization can optimize object-oriented programs written using design patterns. On the other hand, design pat...

Hematopoietic stem cell transplantation in sickle cell disease: patient selection and special considerations

Directory of Open Access Journals (Sweden)

Bhatia M

2015-07-01

Full Text Available Monica Bhatia,1 Sujit Sheth21Division of Pediatric Hematology/Oncology/Stem Cell Transplantation, Columbia University Medical Center, 2Division of Pediatric Hematology and Oncology, Weill Cornell Medical College, New York, NY, USAAbstract: Hematopoietic stem cell transplantation remains the only curative treatment currently in use for patients with sickle cell disease (SCD. The first successful hematopoietic stem cell transplantation was performed in 1984. To date, approximately 1,200 transplants have been reported. Given the high prevalence of this disorder in Africa, and its emergence in the developed world through immigration, this number is relatively small. There are many reasons for this; primary among them are the availability of a donor, the risks associated with this complex procedure, and the cost and availability of resources in the developing world. Of these, it is fair to say that the risks associated with the procedure have steadily decreased to the point where, if currently performed in a center with experience using a matched sibling donor, overall survival is close to 100% and event-free survival is over 90%. While there is little controversy around offering hematopoietic stem cell transplantation to symptomatic SCD patients with a matched sibling donor, there is much debate surrounding the use of this modality in “less severe” patients. An overview of the current state of our understanding of the pathology and treatment of SCD is important to show that our current strategy is not having the desired impact on survival of homozygous SCD patients, and should be changed to significantly impact the small proportion of these patients who have matched siblings and could be cured, especially those without overt clinical manifestations. Both patient families and providers must be made to understand the progressive nature of SCD, and should be encouraged to screen full siblings of patients with homozygous SCD for their potential to

Special software for computing the special functions of wave catastrophes

Directory of Open Access Journals (Sweden)

Andrey S. Kryukovsky

2015-01-01

Full Text Available The method of ordinary differential equations in the context of calculating the special functions of wave catastrophes is considered. Complementary numerical methods and algorithms are described. The paper shows approaches to accelerate such calculations using capabilities of modern computing systems. Methods for calculating the special functions of wave catastrophes are considered in the framework of parallel computing and distributed systems. The paper covers the development process of special software for calculating of special functions, questions of portability, extensibility and interoperability.

Brazing of special metallic materials and material combinations using a special material

International Nuclear Information System (INIS)

Lison, R.

1981-01-01

The special materials include metals of groups IVa, Va and VIa of the periodic tables and their alloys. Their particular properties have won them applications in many highly specialized industries. For these materials to be used, mastery of thermal joining methods appropriate to their characteristics is necessary. High-temperature brazing is one such method for joining special materials. This paper presents variants of this technique suitable for each individual special material. Compatibility tests between various brazing metals and various special materials have been carried out by simulating the temperature/time cycle involved in brazing procedures. Special materials are relatively expensive, and their special properties are not required at every point in a structure: elsewhere they can be replaced by a different special material or by other metals or alloys. This means that joints must be made between two special materials or between a special material and a conventional material. When certain conditions are fulfilled, such joins can be made by high-temperature brazing. This paper also shows the extent to which the geometry of the join determines the choice of process. Example of applications are also given. (orig.)

Characterization of nonlymphoid cells in rat spleen, with special reference to strongly Ia-positive branched cells in T-cell areas

International Nuclear Information System (INIS)

Dijkstra, C.D.

1982-01-01

By use of a monoclonal antibody against Ia antigen in an immunoperoxidase method, strongly Ia-positive branched cells are found in the T-cell areas of the splenic white pulp of the rat. In order to further characterize these cells, enzyme histochemical characteristics, phagocytic capacity, and irradiation sensitivity have been studied. Evidence is presented that these strongly Ia-positive branched cells represent interdigitating cells. The influence of whole-body irradiation on interdigitating cells is discussed. Comparison with data from the literature on the in vitro dendritic cell isolated from spleen cell suspensions reveals many similarities between the described interdigitating cell in vivo and the dendritic cell in vitro

Birthdating studies reshape models for pituitary gland cell specification.

Science.gov (United States)

Davis, Shannon W; Mortensen, Amanda H; Camper, Sally A

2011-04-15

The intermediate and anterior lobes of the pituitary gland are derived from an invagination of oral ectoderm that forms Rathke's pouch. During gestation proliferating cells are enriched around the pouch lumen, and they appear to delaminate as they exit the cell cycle and differentiate. During late mouse gestation and the postnatal period, anterior lobe progenitors re-enter the cell cycle and expand the populations of specialized, hormone-producing cells. At birth, all cell types are present, and their localization appears stratified based on cell type. We conducted a birth dating study of Rathke's pouch derivatives to determine whether the location of specialized cells at birth is correlated with the timing of cell cycle exit. We find that all of the anterior lobe cell types initiate differentiation concurrently with a peak between e11.5 and e13.5. Differentiation of intermediate lobe melanotropes is delayed relative to anterior lobe cell types. We discovered that specialized cell types are not grouped together based on birth date and are dispersed throughout the anterior lobe. Thus, the apparent stratification of specialized cells at birth is not correlated with cell cycle exit. Thus, the currently popular model of cell specification, dependent upon timing of extrinsic, directional gradients of signaling molecules, needs revision. We propose that signals intrinsic to Rathke's pouch are necessary for cell specification between e11.5 and e13.5 and that cell-cell communication likely plays an important role in regulating this process. Copyright © 2011 Elsevier Inc. All rights reserved.

Algorithmically specialized parallel computers

CERN Document Server

Snyder, Lawrence; Gannon, Dennis B

1985-01-01

Algorithmically Specialized Parallel Computers focuses on the concept and characteristics of an algorithmically specialized computer.This book discusses the algorithmically specialized computers, algorithmic specialization using VLSI, and innovative architectures. The architectures and algorithms for digital signal, speech, and image processing and specialized architectures for numerical computations are also elaborated. Other topics include the model for analyzing generalized inter-processor, pipelined architecture for search tree maintenance, and specialized computer organization for raster

Specialized languages

DEFF Research Database (Denmark)

Mousten, Birthe; Laursen, Anne Lise

2016-01-01

Across different fields of research, one feature is often overlooked: the use of language for specialized purposes (LSP) as a cross-discipline. Mastering cross-disciplinarity is the precondition for communicating detailed results within any field. Researchers in specialized languages work cross...... science fields communicate their findings. With this article, we want to create awareness of the work in this special area of language studies and of the inherent cross-disciplinarity that makes LSP special compared to common-core language. An acknowledgement of the importance of this field both in terms...... of more empirical studies and in terms of a greater application of the results would give language specialists in trade and industry a solid and updated basis for communication and language use....

Direct methanol feed fuel cell and system

Science.gov (United States)

Surampudi, Subbarao (Inventor); Frank, Harvey A. (Inventor); Narayanan, Sekharipuram R. (Inventor); Chun, William (Inventor); Jeffries-Nakamura, Barbara (Inventor); Kindler, Andrew (Inventor); Halpert, Gerald (Inventor)

2009-01-01

Improvements to non acid methanol fuel cells include new formulations for materials. The platinum and ruthenium are more exactly mixed together. Different materials are substituted for these materials. The backing material for the fuel cell electrode is specially treated to improve its characteristics. A special sputtered electrode is formed which is extremely porous. The fuel cell system also comprises a fuel supplying part including a meter which meters an amount of fuel which is used by the fuel cell, and controls the supply of fuel based on said metering.

The identification of specialized pacemaking cells in the anal sphincters.

Science.gov (United States)

Shafik, Ahmed; El Sibai, Olfat; Ahmed, Ismail

2006-07-01

Interstitial cells of Cajal (ICC) are claimed to generate the electrical activity in the colon and stomach. As the external (EAS) and internal (IAS) anal sphincters exhibit resting electrical activity, we hypothesized the presence of ICC in these sphincters. This hypothesis was investigated in the current study. Specimens from the EAS and IAS were taken from normal areas of the anorectum which had been surgically excised by abdominoperineal operation for rectal cancer of 28 patients (16 men, 12 women, mean age 42.2+/-4.8 years). The specimens were subjected to c-kit immunohistochemistry. Controls for the specificity of the antisera consisted of tissue incubation with normal rabbit serum substituted for the primary antiserum. Fusiform, c-kit positive, ICC-like cells were detected in the anal sphincters; they had dendritic processes. They were clearly distinguishable from the non-branching, c-kit negative smooth and striated muscle cells of the anal sphincters. The specimens contained also c-kit positive mast cells, but they had a rounded body with no dendritic processes. Immunoreactivity was absent in negative controls in which the primary antibody was omitted. We have identified, for the first time, cells in EAS and IAS with morphological and immunological phenotypes similar to ICCs of the gut. These cells appear to be responsible for initiating the slow waves recorded from the anal sphincters and for controlling their activity. A deficiency or absence of these cells may affect the anal motile activity. Studies are needed to explore the role of these cells in anal motility disorders.

Special quasirandom structures for binary/ternary group IV random alloys

KAUST Repository

Chroneos, Alexander I.

2010-06-01

Simulation of defect interactions in binary/ternary group IV semiconductor alloys at the density functional theory level is difficult due to the random distribution of the constituent atoms. The special quasirandom structures approach is a computationally efficient way to describe the random nature. We systematically study the efficacy of the methodology and generate a number of special quasirandom cells for future use. In order to demonstrate the applicability of the technique, the electronic structures of E centers in Si1-xGex and Si1-x -yGexSny alloys are discussed for a range of nearest neighbor environments. © 2010 Elsevier B.V. All rights reserved.

Use of Special Operations Forces in United Nations Missions: a Method to Resolve Complexity

Science.gov (United States)

2015-05-21

physical stamina and psychological stability, followed by a rigorous training program are the imperatives to create SOF soldiers.42 Mark Bowden in...recommendation is that the United Nations should establish a Special Operations planning cell within the UN Department of Peacekeeping Operations. As of...now, the cell is nonexistent. This cell should be able to facilitate the integration of SOF into the overall peace operations concept. Finally, the

75 FR 47798 - Office of Special Education and Rehabilitative Services-Special Demonstration Programs-Model...

Science.gov (United States)

2010-08-09

... DEPARTMENT OF EDUCATION Office of Special Education and Rehabilitative Services--Special... of Special Education and Rehabilitative Services, Department of Education. ACTION: Notice of final... for Special Education and Rehabilitative Services establishes a priority under the Special...

75 FR 14582 - Office of Special Education and Rehabilitative Services-Special Demonstration Programs-Model...

Science.gov (United States)

2010-03-26

... DEPARTMENT OF EDUCATION Office of Special Education and Rehabilitative Services--Special... of Special Education and Rehabilitative Services, Department of Education. ACTION: Notice of proposed... for Special Education and Rehabilitative Services proposes a priority under the Special Demonstration...

Other Special Waste

DEFF Research Database (Denmark)

Brogaard, Line Kai-Sørensen; Christensen, Thomas Højlund

2011-01-01

In addition to the main types of special waste related to municipal solid waste (MSW) mentioned in the previous chapters (health care risk waste, WEEE, impregnated wood, hazardous waste) a range of other fractions of waste have in some countries been defined as special waste that must be handled...... separately from MSW. Some of these other special wastes are briefly described in this chapter with respect to their definition, quantity and composition, and management options. The special wastes mentioned here are batteries, tires, polyvinylchloride (PVC) and food waste....

The 'SILOE' reactor at Grenoble, France and associated hot cell facilities. Information sheets

International Nuclear Information System (INIS)

Hardt, P. von der; Roettger, H.

1981-01-01

Technical information is given on the SILOE reactor and associated hot cell facilities, with the main emphasis on experimental irradiation facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of eight information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

The 'OSIRIS' reactor at Saclay, France and available hot cell facilities. Information sheets

International Nuclear Information System (INIS)

Hardt, P. von der; Roettger, H.

1981-01-01

Technical information is given on the OSIRIS reactor and associated hot cell facilities, with the main emphasis on experimental irradiation facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of eight information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

Trophoblast cells of ruminant placentas - A mini review

International Nuclear Information System (INIS)

Igwebuike, U.M.

2004-09-01

Understanding of ruminant placental structure and function is essential for veterinarians and researchers. The ruminant placenta is classified as cotyledonary and synepitheliochorial on the bases of its gross anatomical features and histological characteristics respectively. The richly vascularized embryonic chorioallantois is lined on its outer surface by cells of the trophectodermal epithelium. These cells which assume specialized functions are referred to as trophoblast cells. Two morphologically and functionally distinct cell types have been recognized in the trophectoderm of the placenta of ruminant animals. These are the mononucleate trophoblast cells and the binucleate trophoblast cells. The occurrence, morphological characteristics, and specialized functions of these trophoblast cells, in relation to conceptus nutrition and survival in utero are discussed in this review. (author)

Human induced pluripotent stem cell-derived vascular smooth muscle cells

DEFF Research Database (Denmark)

Ayoubi, Sohrab; Sheikh, Søren P; Eskildsen, Tilde V

2017-01-01

. To this end, human induced pluripotent stem cells (hiPSCs) have generated great enthusiasm, and have been a driving force for development of novel strategies in drug discovery and regenerative cell-therapy for the last decade. Hence, investigating the mechanisms underlying the differentiation of hi......PSCs into specialized cell types such as cardiomyocytes, endothelial cells, and vascular smooth muscle cells (VSMCs) may lead to a better understanding of developmental cardiovascular processes and potentiate progress of safe autologous regenerative therapies in pathological conditions. In this review, we summarize...

Fatty acid profile and elemental content of avocado (Persea americana Mill.) oil--effect of extraction methods.

Science.gov (United States)

Reddy, Mageshni; Moodley, Roshila; Jonnalagadda, Sreekanth B

2012-01-01

Interest in vegetable oil extracted from idioblast cells of avocado fruit is growing. In this study, five extraction methods to produce avocado oil have been compared: traditional solvent extraction using a Soxhlet or ultrasound, Soxhlet extraction combined with microwave or ultra-turrax treatment and supercritical fluid extraction (SFE). Traditional Soxhlet extraction produced the most reproducible results, 64.76 ± 0.24 g oil/100 g dry weight (DW) and 63.67 ± 0.20 g oil/100 g DW for Hass and Fuerte varieties, respectively. Microwave extraction gave the highest yield of oil (69.94%) from the Hass variety. Oils from microwave extraction had the highest fatty acid content; oils from SFE had wider range of fatty acids. Oils from Fuerte variety had a higher monounsaturated: saturated FA ratio (3.45-3.70). SFE and microwave extraction produced the best quality oil, better than traditional Soxhlet extraction, with the least amount of oxidizing metals present. Copyright © Taylor & Francis Group, LLC

Ionizing radiation induces senescence and differentiation of human dental pulp stem cells.

Science.gov (United States)

Havelek, R; Soukup, T; Ćmielová, J; Seifrtová, M; Suchánek, J; Vávrová, J; Mokrý, J; Muthná, D; Řezáčová, M

2013-01-01

Head and neck cancer is one of the most common cancers in Europe. Many current anti-cancer treatments, including ionizing radiation, induce apoptosis via DNA damage. Unfortunately, such treatments are non-selective to cancer cells and produce similar toxicity in normal cells, including adult stem cells. One of the fundamental properties of an adult stem cell is that it does not have any tissue-specific structures that allow it to perform specialized functions. However, under certain stimuli, unspecialized adult stem cells can give rise to specialized cells to generate replacements for cells that are lost during one's life or due to injury or disease. Nevertheless, specialization of stem cells must be controlled by specific milieu and also initiated at the proper time, making the entire process beneficial for tissue recovery and maintaining it for a long time. In this paper we assess whether irradiated dental pulp stem cells have maintained open their options to mature into specialized cells, or whether they have lost their unspecialized (immature) state following irradiation. Our findings showed radiation-induced premature differentiation of dental pulp stem cells towards odonto-/osteoblast lineages in vitro. Matrix calcification was visualized from Day 6 or Day 9 following irradiation of cells expressing low or high levels of CD146, respectively.

Principals' and Special Education Teachers' Perceptions of Special Education Teachers' Roles and Responsibilities

Science.gov (United States)

Mott, Japhia

2013-01-01

This explanatory mixed methods study focuses on the perceptions of principals and special education teachers about special education teachers' roles and responsibilities. An online survey was conducted with 11 principals and 41 special education teachers (Resource Specialists and Special Day Class teachers). Independent semi-structured interviews…

EDITORIAL: Special issue on optical micromanipulation

Science.gov (United States)

Heckenberg, N.; Dholakia, K.

2007-08-01

Few would have predicted the impact the laser has had across all of the natural sciences. Laser technology in tandem with microscopy has fuelled a revolutionary advance in biology and chemistry. Microscopic methods permit imaging of cells, nanoparticles, atoms and single molecules. Without doubt, biophotonics has emerged in many guises as a major player on the international arena, and has spawned an industry with an explosive growth rate. Notably, the influence of light is not restricted to passive imaging—it may also move, trap and manoeuvre objects from single atoms right through to the size of a large cell with no damage whatsoever. Given the well-known uses of high power lasers in surgery and industrial cutting, this sounds like science fiction, but at the size scale of these objects it is science fact: it is the area of optical micromanipulation that is the subject of this special issue. The field of optical micromanipulation has continued to impact right across the sciences in an unprecedented fashion, since its inception in the late 1960s. Excitingly the field has made an exceptional impact in single molecule biophysics and the physics of non-equilibrium systems largely due to the fact that an optical trap is an elegant and powerful force transducer. The field is also branching out into new directions: cell biology is benefiting from this advance. Trapping and microfluidics is an exciting combination within the broader remit of the field of optofluidics: methods of multiple traps using diffractive optics are permitting cell sorting, traps are aiding local viscosity measurements and novel biological studies are being performed. Combining traps with other spectroscopic methods and imaging modes is an interesting theme that poses interesting challenges but promises exciting new knowledge. All these areas are represented in this special issue, along with a number of contributions to quantitative modelling of optical fields suitable for trapping and of the

Dendritic cell-mediated T cell polarization

NARCIS (Netherlands)

de Jong, Esther C.; Smits, Hermelijn H.; Kapsenberg, Martien L.

2005-01-01

Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4(+) T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T

Proteolytic Enzymes Clustered in Specialized Plasma-Membrane Domains Drive Endothelial Cells' Migration.

Directory of Open Access Journals (Sweden)

Monica Salamone

Full Text Available In vitro cultured endothelial cells forming a continuous monolayer establish stable cell-cell contacts and acquire a "resting" phenotype; on the other hand, when growing in sparse conditions these cells acquire a migratory phenotype and invade the empty area of the culture. Culturing cells in different conditions, we compared expression and clustering of proteolytic enzymes in cells having migratory versus stationary behavior. In order to observe resting and migrating cells in the same microscopic field, a continuous cell monolayer was wounded. Increased expression of proteolytic enzymes was evident in cell membranes of migrating cells especially at sprouting sites and in shed membrane vesicles. Gelatin zymography and western blotting analyses confirmed that in migrating cells, expression of membrane-bound and of vesicle-associated proteolytic enzymes are increased. The enzymes concerned include MMP-2, MMP-9, MT1-MMP, seprase, DPP4 (DiPeptidyl Peptidase 4 and uPA. Shed membrane vesicles were shown to exert degradative activity on ECM components and produce substrates facilitating cell migration. Vesicles shed by migrating cells degraded ECM components at an increased rate; as a result their effect on cell migration was amplified. Inhibiting either Matrix Metallo Proteases (MMPs or Serine Integral Membrane Peptidases (SIMPs caused a decrease in the stimulatory effect of vesicles, inhibiting the spontaneous migratory activity of cells; a similar result was also obtained when a monoclonal antibody acting on DPP4 was tested. We conclude that proteolytic enzymes have a synergistic stimulatory effect on cell migration and that their clustering probably facilitates the proteolytic activation cascades needed to produce maximal degradative activity on cell substrates during the angiogenic process.

Proteolytic Enzymes Clustered in Specialized Plasma-Membrane Domains Drive Endothelial Cells' Migration.

Science.gov (United States)

Salamone, Monica; Carfì Pavia, Francesco; Ghersi, Giulio

2016-01-01

In vitro cultured endothelial cells forming a continuous monolayer establish stable cell-cell contacts and acquire a "resting" phenotype; on the other hand, when growing in sparse conditions these cells acquire a migratory phenotype and invade the empty area of the culture. Culturing cells in different conditions, we compared expression and clustering of proteolytic enzymes in cells having migratory versus stationary behavior. In order to observe resting and migrating cells in the same microscopic field, a continuous cell monolayer was wounded. Increased expression of proteolytic enzymes was evident in cell membranes of migrating cells especially at sprouting sites and in shed membrane vesicles. Gelatin zymography and western blotting analyses confirmed that in migrating cells, expression of membrane-bound and of vesicle-associated proteolytic enzymes are increased. The enzymes concerned include MMP-2, MMP-9, MT1-MMP, seprase, DPP4 (DiPeptidyl Peptidase 4) and uPA. Shed membrane vesicles were shown to exert degradative activity on ECM components and produce substrates facilitating cell migration. Vesicles shed by migrating cells degraded ECM components at an increased rate; as a result their effect on cell migration was amplified. Inhibiting either Matrix Metallo Proteases (MMPs) or Serine Integral Membrane Peptidases (SIMPs) caused a decrease in the stimulatory effect of vesicles, inhibiting the spontaneous migratory activity of cells; a similar result was also obtained when a monoclonal antibody acting on DPP4 was tested. We conclude that proteolytic enzymes have a synergistic stimulatory effect on cell migration and that their clustering probably facilitates the proteolytic activation cascades needed to produce maximal degradative activity on cell substrates during the angiogenic process.

Special energies and special frequencies

International Nuclear Information System (INIS)

Endrullis, M.; Englisch, H.

1987-01-01

''Special frequencies'' have been asserted to be zeros of the density of frequencies corresponding to a random chain of coupled oscillators. Our investigation includes both this model and the random one-dimensional Schroedinger operator describing an alloy or its discrete analogue. Using the phase method we exactly determine a bilateral Lifsic asymptotic of the integrated density of states k(E) at special energies G s , which is not only of the classical type exp(-c/vertical strokeE-E s vertical stroke 1/2 ) but also exp(-c'/vertical strokeE-E s vertical stroke) is a typical behaviour. In addition, other asymptotics occur, e.g. vertical strokeE-E c vertical stroke c '', which show that k(E) need not be C ∞ . (orig.)

Erythroblastic Islands: Specialized Mircoenvironmental Niches forErythropoiesis

Energy Technology Data Exchange (ETDEWEB)

Chasis, Joel Anne

2006-01-06

This review focuses on current understanding of molecular mechanisms operating within erythroblastic islands including cell-cell adhesion, regulatory feedback, and central macrophage function. RECENT FINDINGS: Erythroblasts express a variety of adhesion molecules and recently two interactions have been identified that appear to be critical for island integrity. Erythroblast macrophage protein, expressed on erythroblasts and macrophages, mediates cell-cell attachments via homophilic binding. Erythroblast intercellular adhesion molecule-4 links erythroblasts to macrophages through interaction with macrophage alphav integrin. In intercellular adhesion molecule-4 knockout mice, erythroblastic islands are markedly reduced, whereas the erythroblast macrophage protein null phenotype is severely anemic and embryonic lethal. Retinoblastoma tumor suppressor (Rb) protein stimulates macrophage differentiation by counteracting inhibition of Id2 on PU.1, a transcription factor that is a crucial regulator of macrophage differentiation. Rb-deficient macrophages do not bind Rb null erythroblasts and the Rb null phenotype is anemic and embryonic lethal. Lastly, extruded nuclei rapidly expose phosphatidylserine on their surface, providing a recognition signal similar to apoptotic cells. SUMMARY: Although understanding of molecular mechanisms operating within islands is at an early stage, tantalizing evidence suggests that erythroblastic islands are specialized niches where intercellular interactions in concert with cytokines play critical roles in regulating erythropoiesis.

The DIDO-reactor at Harwell, U.K. and ancillary hot cell facilities. Information sheets

International Nuclear Information System (INIS)

Hardt, P. von der; Roettger, H.

1981-01-01

Technical information is given on the DIDO reactor and associated hot cell facilities, with the main emphasis on experimental irradiation facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of eight information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

Integrative Approaches for the Identification and Localization of Specialized Metabolites in Tripterygium Roots1[OPEN

Science.gov (United States)

Fischedick, Justin T.; Lange, Malte F.; Poirier, Brenton C.

2017-01-01

Members of the genus Tripterygium are known to contain an astonishing diversity of specialized metabolites. The lack of authentic standards has been an impediment to the rapid identification of such metabolites in extracts. We employed an approach that involves the searching of multiple, complementary chromatographic and spectroscopic data sets against the Spektraris database to speed up the metabolite identification process. Mass spectrometry-based imaging indicated a differential localization of triterpenoids to the periderm and sesquiterpene alkaloids to the cortex layer of Tripterygium roots. We further provide evidence that triterpenoids are accumulated to high levels in cells that contain suberized cell walls, which might indicate a mechanism for storage. To our knowledge, our data provide first insights into the cell type specificity of metabolite accumulation in Tripterygium and set the stage for furthering our understanding of the biological implications of specialized metabolites in this genus. PMID:27864443

Normal and abnormal secretion by haemopoietic cells

Science.gov (United States)

STINCHCOMBE, JANE C; GRIFFITHS, GILLIAN M

2001-01-01

The secretory lysosomes found in haemopoietic cells provide a very efficient mechanism for delivering the effector proteins of many immune cells in response to antigen recognition. Although secretion shows some similarities to the secretion of specialized granules in other secretory cell types, some aspects of secretory lysosome release appear to be unique to melanocytes and cells of the haemopoietic lineage. Mast cells and platelets have provided excellent models for studying secretion, but recent advances in characterizing the immunological synapse allow a very fine dissection of the secretory process in T lymphocytes. These studies show that secretory lysosomes are secreted from the centre of the talin ring at the synapse. Proper secretion requires a series of Rab and cytoskeletal elements which play critical roles in the specialized secretion of lysosomes in haemopoietic cells. PMID:11380687

Special set linear algebra and special set fuzzy linear algebra

OpenAIRE

Kandasamy, W. B. Vasantha; Smarandache, Florentin; Ilanthenral, K.

2009-01-01

The authors in this book introduce the notion of special set linear algebra and special set fuzzy Linear algebra, which is an extension of the notion set linear algebra and set fuzzy linear algebra. These concepts are best suited in the application of multi expert models and cryptology. This book has five chapters. In chapter one the basic concepts about set linear algebra is given in order to make this book a self contained one. The notion of special set linear algebra and their fuzzy analog...

Skeletal (stromal) stem cells

DEFF Research Database (Denmark)

Abdallah, Basem M; Kermani, Abbas Jafari; Zaher, Walid

2015-01-01

Skeletal (marrow stromal) stem cells (BMSCs) are a group of multipotent cells that reside in the bone marrow stroma and can differentiate into osteoblasts, chondrocytes and adipocytes. Studying signaling pathways that regulate BMSC differentiation into osteoblastic cells is a strategy....../preadipocyte factor 1 (Dlk1/Pref-1), the Wnt co-receptor Lrp5 and intracellular kinases. This article is part of a Special Issue entitled: Stem Cells and Bone....

The cell wall of Fusarium oxysporum

NARCIS (Netherlands)

Schoffelmeer, EAM; Klis, FM; Sietsma, JH; Cornelissen, BJC

1999-01-01

Sugar analysis of isolated cell walls from three formae speciales of Fusarium oxysporum showed that they contained not only glucose and (N-acetyl)-glucosamine, but also mannose, galactose, and uronic acids, presumably originating from cell wall glycoproteins. Cell wall glycoproteins accounted for

The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function.

Science.gov (United States)

Isern, Joan; García-García, Andrés; Martín, Ana M; Arranz, Lorena; Martín-Pérez, Daniel; Torroja, Carlos; Sánchez-Cabo, Fátima; Méndez-Ferrer, Simón

2014-09-25

Mesenchymal stem cells (MSCs) and osteolineage cells contribute to the hematopoietic stem cell (HSC) niche in the bone marrow of long bones. However, their developmental relationships remain unclear. In this study, we demonstrate that different MSC populations in the developing marrow of long bones have distinct functions. Proliferative mesoderm-derived nestin(-) MSCs participate in fetal skeletogenesis and lose MSC activity soon after birth. In contrast, quiescent neural crest-derived nestin(+) cells preserve MSC activity, but do not generate fetal chondrocytes. Instead, they differentiate into HSC niche-forming MSCs, helping to establish the HSC niche by secreting Cxcl12. Perineural migration of these cells to the bone marrow requires the ErbB3 receptor. The neonatal Nestin-GFP(+) Pdgfrα(-) cell population also contains Schwann cell precursors, but does not comprise mature Schwann cells. Thus, in the developing bone marrow HSC niche-forming MSCs share a common origin with sympathetic peripheral neurons and glial cells, and ontogenically distinct MSCs have non-overlapping functions in endochondrogenesis and HSC niche formation.

Automatized welding equipment for manufacturing steel cells for special buildings

International Nuclear Information System (INIS)

Weikert, F.; Winter, K.P.

1986-01-01

In GDR's nuclear power plant construction, reinforced concrete wall cells are used to construct pressure and full pressure containments for WWER-440 and WWER-1000 reactors, respectively. Welding processes for the prefabrication of steel cells as reinforcement have been automatized in order to increase both labor productivity and quality assurance. 11 figs

Common Features of Regulatory T Cell Specialization During Th1 Responses

Directory of Open Access Journals (Sweden)

Katharina Littringer

2018-06-01

Full Text Available CD4+Foxp3+ Treg cells are essential for maintaining self-tolerance and preventing excessive immune responses. In the context of Th1 immune responses, co-expression of the Th1 transcription factor T-bet with Foxp3 is essential for Treg cells to control Th1 responses. T-bet-dependent expression of CXCR3 directs Treg cells to the site of inflammation. However, the suppressive mediators enabling effective control of Th1 responses at this site are unknown. In this study, we determined the signature of CXCR3+ Treg cells arising in Th1 settings and defined universal features of Treg cells in this context using multiple Th1-dominated infection models. Our analysis defined a set of Th1-specific co-inhibitory receptors and cytotoxic molecules that are specifically expressed in Treg cells during Th1 immune responses in mice and humans. Among these, we identified the novel co-inhibitory receptor CD85k as a functional predictor for Treg-mediated suppression specifically of Th1 responses, which could be explored therapeutically for selective immune suppression in autoimmunity.

Developments in special geometry

International Nuclear Information System (INIS)

Mohaupt, Thomas; Vaughan, Owen

2012-01-01

We review the special geometry of N = 2 supersymmetric vector and hypermultiplets with emphasis on recent developments and applications. A new formulation of the local c-map based on the Hesse potential and special real coordinates is presented. Other recent developments include the Euclidean version of special geometry, and generalizations of special geometry to non-supersymmetric theories. As applications we discuss the proof that the local r-map and c-map preserve geodesic completeness, and the construction of four- and five-dimensional static solutions through dimensional reduction over time. The shared features of the real, complex and quaternionic version of special geometry are stressed throughout.

The DR 3 reactor at Risoe, Denmark and its associated hot cell facilities. Information sheets

International Nuclear Information System (INIS)

Hardt, P. von der; Roettger, H.

1981-01-01

Technical information is given on the DR 2 reactor and associated hot cell facilities, with the main emphasis on experimental irradiation facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of seven information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

75 FR 47801 - Office of Special Education and Rehabilitative Services; Overview Information; Special...

Science.gov (United States)

2010-08-09

... DEPARTMENT OF EDUCATION Office of Special Education and Rehabilitative Services; Overview Information; Special Demonstration Programs--Model Demonstration Projects To Improve Outcomes for Individuals.... Alexa Posny, Assistant Secretary for Special Education and Rehabilitative Services. [FR Doc. 2010-19585...

The FR 2 reactor at Karlsruhe, F.R. Germany and associated hot cell facilities. Information sheets

International Nuclear Information System (INIS)

Hardt, P. von der; Roettger, H.

1981-01-01

Technical information is given on the FR 2 reactor and associated hot cell facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of eight information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

Hematopoietic stem cell origin of connective tissues.

Science.gov (United States)

Ogawa, Makio; Larue, Amanda C; Watson, Patricia M; Watson, Dennis K

2010-07-01

Connective tissue consists of "connective tissue proper," which is further divided into loose and dense (fibrous) connective tissues and "specialized connective tissues." Specialized connective tissues consist of blood, adipose tissue, cartilage, and bone. In both loose and dense connective tissues, the principal cellular element is fibroblasts. It has been generally believed that all cellular elements of connective tissue, including fibroblasts, adipocytes, chondrocytes, and bone cells, are generated solely by mesenchymal stem cells. Recently, a number of studies, including those from our laboratory based on transplantation of single hematopoietic stem cells, strongly suggested a hematopoietic stem cell origin of these adult mesenchymal tissues. This review summarizes the experimental evidence for this new paradigm and discusses its translational implications. Copyright 2010 ISEH - Society for Hematology and Stem Cells. All rights reserved.

Special relativity

International Nuclear Information System (INIS)

Taylor, J.G.

1975-01-01

It is stated that the early chapters review special relativity from an elementary mathematical viewpoint, and include discussion of recent experiments which set out to test Einstein's predictions. The theory of relativity is then reformulated in more sophisticated mathematical language to show its relation to electro-magnetism, and to lay the foundation for more general viewpoints. The final chapter discusses in simple terms where activity in the field is currently centred, and where future interest lies. Chapter headings include: the constant speed of light; measuring time and distance; the Lorentz transformation (relativity of simultaneity, space-time and causality); relativistic kinematics (including - the Dopper effect); relativistic dynamics (including - nuclear binding energy, particle creation, electrodynamics); the structure of special relativity (including - the Lorentz group, the rotation group, elementary particle scattering); extensions of special relativity. (U.K.)

A Modified NK Cell Degranulation Assay Applicable for Routine Evaluation of NK Cell Function

Directory of Open Access Journals (Sweden)

Snehal Shabrish

2016-01-01

Full Text Available Natural killer (NK cells play important role in innate immunity against tumors and viral infections. Studies show that lysosome-associated membrane protein-1 (LAMP-1, CD107a is a marker for degranulation of NK and cytotoxic T cells and its expression is a sensitive marker for the cytotoxic activity determination. The conventional methods of determination of CD107a on NK cells involve use of peripheral blood mononuclear cells (PBMC or pure NK cells and K562 cells as stimulants. Thus, it requires large volume of blood sample which is usually difficult to obtain in pediatric patients and patients with cytopenia and also requires specialized laboratory for maintaining cell line. We have designed a flow cytometric assay to determine CD107a on NK cells using whole blood, eliminating the need for isolation of PBMC or isolate NK cells. This assay uses phorbol-12-myristate-13-acetate (PMA and calcium ionophore (Ca2+-ionophore instead of K562 cells for stimulation and thus does not require specialized cell culture laboratory. CD107a expression on NK cells using modified NK cell degranulation assay compared to the conventional assay was significantly elevated (p<0.0001. It was also validated by testing patients diagnosed with familial hemophagocytic lymphohistiocytosis (FHL with defect in exocytosis. This assay is rapid, cost effective, and reproducible and requires significantly less volume of blood which is important for clinical evaluation of NK cells.

Special protective concretes

International Nuclear Information System (INIS)

Bouniol, P.

2001-01-01

Concrete is the most convenient material when large-scale radiation protection is needed. Thus, special concretes for nuclear purposes are used in various facilities like reactors, reprocessing centers, storage sites, accelerators, hospitals with nuclear medicine equipment, food ionization centers etc.. The recent advances made in civil engineering for the improvement of concrete durability and compactness are for a large part transposable to protection concretes. This article presents the basic knowledge about protection concretes with the associated typological and technological aspects. A large part is devoted to the intrinsic properties of concretes and to their behaviour in irradiation and temperature conditions: 1 - definition and field of application of special protective concretes; 2 - evolution of concepts and technologies (durability of structures, techniques of formulation, new additives, market evolution); 3 - design of protective structures (preliminary study, radiation characteristics, thermal constraints, damping and dimensioning, mechanical criteria); 4 - formulation of special concretes (general principles, granulates, hydraulic binders, pulverulent additives, water/cement ratio, reference composition of some special concretes); 5 - properties of special concretes (damping and thermo-mechanical properties); 6 - induced-irradiation and temperature phenomena (activation, radiolysis, mineralogical transformations, drying, shrinking, creep, corrosion of reinforcement). (J.S.)

Prospective Special Education Teachers' Metaphorical Perceptions on the Concept of Special Education Teacher

Science.gov (United States)

Deniz, Levent

2016-01-01

The aim of this research is to define the perceptions of prospective special education teachers regarding special education teacher through metaphors. Phenomenology design was used in this research. The study group comprised 116 third year prospective special education teachers studying at Marmara University, Ataturk Faculty of Education, Special…

Morfoanatomia de rizomas e raízes de Tillandsia L. (Bromeliaceae dos Campos Gerais, PR, Brasil Morphology and anatomy of rhizomes and roots in Tillandsia L. (Bromeliaceae from the "Campos Gerais", PR, Brazil

Directory of Open Access Journals (Sweden)

Simone Segecin

2004-06-01

. streptocarpa Baker, T. tenuifolia L. and Tillandsia sp. They are epiphytes. The rhizomes are horizontal and present intracortical roots. They present uniseriated epidermis or storied cork; cortex with isodiametrical cells, idioblasts with raphide-sacs, and starch grains; uniseriated endodermis presenting thin-walled cells; uniseriated or multiseriated pericycle with thin or thick-walled cells; vascular cylinder presenting collateral vascular bundles. The adventitious roots are intracortical or external. The latter have multiseriated velamen; presenting idioblasts with raphide-sacs, cortical intercellular spaces, exodermis with thick-walled cells; uniseriated endodermis with thin or thick-walled cells; uniseriated pericycle with thin-walled cells; reduced vascular cylinder. The intracortical roots differ of the external ones for the lack of velamen. Most of these adaptative anatomical features might be related to the epiphytic habit of these plants.

Special Libraries and Multitype Networks.

Science.gov (United States)

Segal, JoAn S.

1989-01-01

Describes the history of multitype library networks; examines the reasons why special libraries and other network participants have resisted the inclusion of special libraries in these networks; and discusses the benefits to both special libraries and to other libraries in the network that would result from special library participation. (17…

Special Needs: A Philosophical Analysis

Science.gov (United States)

Vehmas, Simo

2010-01-01

This paper attempts to illuminate a central concept and idea in special education discourse, namely, "special needs". It analyses philosophically what needs are and on what grounds they are defined as "special" or "exceptional". It also discusses whether sorting needs into ordinary and special is discriminatory. It is argued that individualistic…

Sports Specialization in Young Athletes

Science.gov (United States)

Jayanthi, Neeru; Pinkham, Courtney; Dugas, Lara; Patrick, Brittany; LaBella, Cynthia

2013-01-01

Context: Sports specialization is intense training in 1 sport while excluding others. Sports specialization in early to middle childhood has become increasingly common. While most experts agree that some degree of sports specialization is necessary to achieve elite levels, there is some debate as to whether such intense practice time must begin during early childhood and to the exclusion of other sports to maximize potential for success. There is a concern that sports specialization before adolescence may be deleterious to a young athlete. Evidence Acquisition: PubMed and OVID were searched for English-language articles from 1990 to 2011 discussing sports specialization, expert athletes, or elite versus novice athletes, including original research articles, consensus opinions, and position statements. Results: For most sports, there is no evidence that intense training and specialization before puberty are necessary to achieve elite status. Risks of early sports specialization include higher rates of injury, increased psychological stress, and quitting sports at a young age. Sports specialization occurs along a continuum. Survey tools are being developed to identify where athletes fall along the spectrum of specialization. Conclusion: Some degree of sports specialization is necessary to develop elite-level skill development. However, for most sports, such intense training in a single sport to the exclusion of others should be delayed until late adolescence to optimize success while minimizing injury, psychological stress, and burnout. PMID:24427397

Cell suicide

International Nuclear Information System (INIS)

May, E.; Coffigny, H.

2000-01-01

In the fight of the cell against the damages caused to its DNA by genotoxic agents and specially by ionizing radiations, the p53 protein plays a central part. It intervenes in the proliferation control and the differentiation but also in the keeping of genome integrity. It can direct the damages cells toward suicide, or apoptosis, to avoid the risk of tumor appearance that would be fatal to the whole organism. That is by the disordered state of cells suicide programs that the tumor cells are going to develop. The knowledge of apoptosis mechanisms, to eventually start them on demand, rises up broad hopes in the cancer therapy. (N.C.)

Influence of Mentoring Programs on Special Educators' Intent to Stay in Special Education

Science.gov (United States)

Perry, Clarissa Simmons

2011-01-01

The lack of certified special education teachers and high rates of attrition have led to a shortage of special educators. Mentoring programs have been developed to improve retention of beginning educators. This study examined if a mentoring program is effective for special educators. The participants were first- and second-year elementary, middle,…

The FRJ 1 reactor (MERLIN) at Juelich, F.R. Germany and associated hot cell facilities. Information sheets

International Nuclear Information System (INIS)

Hardt, P. von der; Roettger, H.

1981-01-01

Technical information is given on the FRJ 1 reactor and associated hot cell facilities, with the main emphasis on experimental irradiation facilities, specialized irradiation devices (loops and capsules) and possibilities for post-irradiation examinations of samples. The information is presented in the form of eight information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities; equipment and techniques available for post-irradiation examinations; utilization and specialization of the hot cell facilities

The 'MELUSINE' reactor at Grenoble, France, and associated hot cell facilities. Information sheets

International Nuclear Information System (INIS)

Hardt, P. von der; Roettger, H.

1981-01-01

Technical information is given on the MELUSINE reactor and associated hot cell facilities, with the main emphasis on experimental irradiation facilities and specialized irradiation devices (loops and capsules). The information is presented in the form of six information sheets under the headings: main characteristics of the reactor; utilization and specialization of the reactor; experimental facilities; neutron spectra; main characteristics of specialized irradiation devices; main characteristics of hot cell facilities

Photoactivated Fuel Cells (PhotoFuelCells. An alternative source of renewable energy with environmental benefits

Directory of Open Access Journals (Sweden)

Stavroula Sfaelou

2016-03-01

Full Text Available This work is a short review of Photoactivated Fuel Cells, that is, photoelectrochemical cells which consume an organic or inorganic fuel to produce renewable electricity or hydrogen. The work presents the basic features of photoactivated fuel cells, their modes of operation, the materials, which are frequently used for their construction and some ideas of cell design both for electricity and solar hydrogen production. Water splitting is treated as a special case of photoactivated fuel cell operation.

Focal adhesions and cell-matrix interactions

DEFF Research Database (Denmark)

Woods, A; Couchman, J R

1988-01-01

Focal adhesions are areas of cell surfaces where specializations of cytoskeletal, membrane and extracellular components combine to produce stable cell-matrix interactions. The morphology of these adhesions and the components identified in them are discussed together with possible mechanisms...

Eukaryogenesis, how special really?

Science.gov (United States)

Booth, Austin; Doolittle, W Ford

2015-08-18

Eukaryogenesis is widely viewed as an improbable evolutionary transition uniquely affecting the evolution of life on this planet. However, scientific and popular rhetoric extolling this event as a singularity lacks rigorous evidential and statistical support. Here, we question several of the usual claims about the specialness of eukaryogenesis, focusing on both eukaryogenesis as a process and its outcome, the eukaryotic cell. We argue in favor of four ideas. First, the criteria by which we judge eukaryogenesis to have required a genuinely unlikely series of events 2 billion years in the making are being eroded by discoveries that fill in the gaps of the prokaryote:eukaryote "discontinuity." Second, eukaryogenesis confronts evolutionary theory in ways not different from other evolutionary transitions in individuality; parallel systems can be found at several hierarchical levels. Third, identifying which of several complex cellular features confer on eukaryotes a putative richer evolutionary potential remains an area of speculation: various keys to success have been proposed and rejected over the five-decade history of research in this area. Fourth, and perhaps most importantly, it is difficult and may be impossible to eliminate eukaryocentric bias from the measures by which eukaryotes as a whole are judged to have achieved greater success than prokaryotes as a whole. Overall, we question whether premises of existing theories about the uniqueness of eukaryogenesis and the greater evolutionary potential of eukaryotes have been objectively formulated and whether, despite widespread acceptance that eukaryogenesis was "special," any such notion has more than rhetorical value.

Immunological characteristics of mesenchymal stem cells

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Cíntia de Vasconcellos Machado

2013-01-01

Full Text Available Although bone marrow is the main source, mesenchymal stem cells have already been isolated from various other tissues, such as the liver, pancreas, adipose tissue, peripheral blood and dental pulp. These plastic adherent cells are morphologically similar to fibroblasts and have a high proliferative potential. This special group of cells possesses two essential characteristics: self-renewal and differentiation, with appropriate stimuli, into various cell types. Mesenchymal stem cells are considered immunologically privileged, since they do not express costimulatory molecules, required for complete T cell activation, on their surface. Several studies have shown that these cells exert an immunosuppressive effect on cells from both innate and acquired immunity systems. Mesenchymal stem cells can regulate the immune response in vitro by inhibiting the maturation of dendritic cells, as well as by suppressing the proliferation and function of T and B lymphocytes and natural killer cells. These special properties of mesenchymal stem cells make them a promising strategy in the treatment of immune mediated disorders, such as graft-versus-host disease and autoimmune diseases, as well as in regenerative medicine. The understanding of immune regulation mechanisms of mesenchymal stem cells, and also those involved in the differentiation of these cells in various lineages is primordial for their successful and safe application in different areas of medicine.

Stem cells in dentistry: A study regarding awareness of stem cells among dental professionals

OpenAIRE

Parita K Chitroda; Girish Katti; Nikhat M Attar; Syed Shahbaz; G Sreenivasarao; Ambika Patil

2017-01-01

Background: Dental stem cell, a type of adult stem cell, exhibits multipotent differentiation capacity and is drawing worldwide attention because of its numerous applications. The advances in applications of dental stem cells seem to be unsurpassed in the near future, for which specialized skills and knowledge in this arena are of prime significance. Hence, there is a need to acquire more knowledge about dental stem cells to obtain maximum benefits from it in the coming years. Dental stem cel...

Specialized functional diversity and interactions of the Na,K-ATPase

Directory of Open Access Journals (Sweden)

Igor I. Krivoi

2016-05-01

Full Text Available Na,K-ATPase is a protein ubiquitously expressed in the plasma membrane of all animal cells and vitally essential for their functions. A specialized functional diversity of the Na,K-ATPase isozymes is provided by molecular heterogeneity, distinct subcellular localizations and functional interactions with molecular environment. Studies over the last decades clearly demonstrated complex and isoform-specific reciprocal functional interactions between the Na,K-ATPase and neighboring proteins and lipids. These interactions are enabled by a spatially restricted ion homeostasis, direct protein-protein/lipid interactions and protein kinase signaling pathways. In addition to its ‘classical’ function in ion translocation, the Na,K-ATPase is now considered as one of the most important signaling molecules in neuronal, epithelial, skeletal, cardiac and vascular tissues. Accordingly, the Na,K-ATPase forms specialized sub-cellular multimolecular microdomains which act as receptors to circulating endogenous cardiotonic steroids triggering a number of signaling pathways. Changes in these endogenous cardiotonic steroid levels and initiated signaling responses have significant adaptive values for tissues and whole organisms under numerous physiological and pathophysiological conditions. This review discusses recent progress in the studies of functional interactions between the Na,K-ATPase and molecular microenvironment, the Na,K-ATPase-dependent signaling pathways and their significance for diversity of cell function.

Facts about Stem Cells and Importance of Them

Directory of Open Access Journals (Sweden)

Masumeh Saeidi

2014-05-01

Full Text Available Stem cells are undifferentiated biological cells that can differentiate into specialized cells and can divide (through mitosis to produce more stem cells. They are found in multicellular organisms. In mammals, there are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocysts, and adult stem cells, which are found in various tissues. In adult organisms, stem cells and progenitor cells act as a repair system for the body, replenishing adult tissues. In a developing embryo, stem cells can differentiate into all the specialized cells—ectoderm, endoderm and mesoderm (see induced pluripotent stem cells—but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues. There are three accessible sources of autologous adult stem cells in humans: Bone marrow, which requires extraction by harvesting, that is, drilling into bone (typically the femur or iliac crest, Adipose tissue (lipid cells, which requires extraction by liposuction, and Blood, which requires extraction through apheresis, wherein blood is drawn from the donor (similar to a blood donation, and passed through a machine that extracts the stem cells and returns other portions of the blood to the donor. Stem cells can also be taken from umbilical cord blood just after birth. Of all stem cell types, autologous harvesting involves the least risk. By definition, autologous cells are obtained from one's own body, just as one may bank his or her own blood for elective surgical procedures. Adult stem cells are frequently used in medical therapies, for example in bone marrow transplantation. Stem cells can now be artificially grown and transformed (differentiated into specialized cell types with characteristics consistent with cells of various tissues such as muscles or nerves. Embryonic cell lines and autologous embryonic stem cells generated through Somatic-cell nuclear transfer or dedifferentiation

Comparison of special stains for keratin with routine hematoxylin and eosin stain.

Science.gov (United States)

Rao, Roopa S; Patil, Shankargouda; Majumdar, Barnali; Oswal, Rakesh G

2015-03-01

Keratins are the most abundant proteins and are characteristic findings in many epithelial pathologies, making it a diagnostically important marker, both histopathologically and immunohistochemically. Since, immunohistochemistry is an expensive diagnostic tool, special stains to detect the degree of keratinization could serve as a faster and economic option. The aim of the present study was to compare the efficacy of special stains for keratin with standard hematoxylin and eosin stain (H and E). Objectives include: (i) To subject the diagnosed cases of keratin disorders to the selected special stains: Ayoub-shklar method, Dane-Herman method, Alcian blue -periodic acid Schiff 's (PAS), rapid papanicolaou (PAP) and Gram's stain. (ii) To compare the staining specificity and staining intensity of special stains with respect to routine hematoxylin and eosin (H and E) stain. (iii) To compare the efficacy of special stains to routine H and E stain in identification of the type of keratin present in the selected cases. A total of 80 cases of known pathology for keratin were retrieved from the department archive, which included 10 each of normal gingiva, hyperkeratosis, squamous papilloma, verrucous hyperplasia, verrucous carcinoma, well-differentiated squamous cell carcinoma, orthokeratinized odontogenic cyst and keratocystic odontogenic tumors. Six sections of 4 µ each from the paraffin blocks were made, stained with H and E and the special stains and these were evaluated by 2 pathologists based on the modified scoring criteria from Rahma Al-Maaini and Philip Bryant 2008. The results were tabulated using Chi square and kappa statistics. The statistical values for identification of the type of keratinization was insignificant showing that ortho and parakeratinized epithelia could be correctly identified by both H and E as well as all the special stains. Furthermore, all the special stains showed a positive result and statistical significance (P < 0.001) with respect to

Special Needs Assistants--The Special Characteristic and Strength of the School System of Finland

Science.gov (United States)

Mäensivu, Kati-Tuulia; Uusiautti, Satu; Määttä, Kaarina

2012-01-01

The contribution of special needs assistants (SNA) is becoming increasingly important in inclusive and special classrooms. However, the profession itself has remained unexplored. The purpose of this article is to describe special needs assistants' perceptions on their education, professional competence, the content and significance of their work…

Health-related biological effects of electric, magnetic, and electro-magnetic fields with special reference to nonthermal effects

International Nuclear Information System (INIS)

Stevenson, A.F.G.

1993-02-01

This expert report is a supplement to the report by L. von Klitzing (The actions and effects of electric, magnetic, and electro-magnetic fields in man with special reference to athermal effects) and concerns in particular the biological effects on cationic homeostasis and cell regulation with special reference to calcium and the effects on the pineal gland. The report concludes with statements on teratogenicity, concerogenicity, mutagenicity and a bibliography of literature. (VHE) [de

Specialized activities and expression differences for Clostridium thermocellum biofilm and planktonic cells.

Science.gov (United States)

Dumitrache, Alexandru; Klingeman, Dawn M; Natzke, Jace; Rodriguez, Miguel; Giannone, Richard J; Hettich, Robert L; Davison, Brian H; Brown, Steven D

2017-02-27

Clostridium (Ruminiclostridium) thermocellum is a model organism for its ability to deconstruct plant biomass and convert the cellulose into ethanol. The bacterium forms biofilms adherent to lignocellulosic feedstocks in a continuous cell-monolayer in order to efficiently break down and uptake cellulose hydrolysates. We developed a novel bioreactor design to generate separate sessile and planktonic cell populations for omics studies. Sessile cells had significantly greater expression of genes involved in catabolism of carbohydrates by glycolysis and pyruvate fermentation, ATP generation by proton gradient, the anabolism of proteins and lipids and cellular functions critical for cell division consistent with substrate replete conditions. Planktonic cells had notably higher gene expression for flagellar motility and chemotaxis, cellulosomal cellulases and anchoring scaffoldins, and a range of stress induced homeostasis mechanisms such as oxidative stress protection by antioxidants and flavoprotein co-factors, methionine repair, Fe-S cluster assembly and repair in redox proteins, cell growth control through tRNA thiolation, recovery of damaged DNA by nucleotide excision repair and removal of terminal proteins by proteases. This study demonstrates that microbial attachment to cellulose substrate produces widespread gene expression changes for critical functions of this organism and provides physiological insights for two cells populations relevant for engineering of industrially-ready phenotypes.

Cell origami: self-folding of three-dimensional cell-laden microstructures driven by cell traction force.

Directory of Open Access Journals (Sweden)

Kaori Kuribayashi-Shigetomi

Full Text Available This paper describes a method of generating three-dimensional (3D cell-laden microstructures by applying the principle of origami folding technique and cell traction force (CTF. We harness the CTF as a biological driving force to fold the microstructures. Cells stretch and adhere across multiple microplates. Upon detaching the microplates from a substrate, CTF causes the plates to lift and fold according to a prescribed pattern. This self-folding technique using cells is highly biocompatible and does not involve special material requirements for the microplates and hinges to induce folding. We successfully produced various 3D cell-laden microstructures by just changing the geometry of the patterned 2D plates. We also achieved mass-production of the 3D cell-laden microstructures without causing damage to the cells. We believe that our methods will be useful for biotechnology applications that require analysis of cells in 3D configurations and for self-assembly of cell-based micro-medical devices.

Cell origami: self-folding of three-dimensional cell-laden microstructures driven by cell traction force.

Science.gov (United States)

Kuribayashi-Shigetomi, Kaori; Onoe, Hiroaki; Takeuchi, Shoji

2012-01-01

This paper describes a method of generating three-dimensional (3D) cell-laden microstructures by applying the principle of origami folding technique and cell traction force (CTF). We harness the CTF as a biological driving force to fold the microstructures. Cells stretch and adhere across multiple microplates. Upon detaching the microplates from a substrate, CTF causes the plates to lift and fold according to a prescribed pattern. This self-folding technique using cells is highly biocompatible and does not involve special material requirements for the microplates and hinges to induce folding. We successfully produced various 3D cell-laden microstructures by just changing the geometry of the patterned 2D plates. We also achieved mass-production of the 3D cell-laden microstructures without causing damage to the cells. We believe that our methods will be useful for biotechnology applications that require analysis of cells in 3D configurations and for self-assembly of cell-based micro-medical devices.

Host cell reactivation in mammalian cells

International Nuclear Information System (INIS)

Lytle, C.D.; Benane, S.G.; Stafford, J.E.

1976-01-01

The survival of UV-irradiated herpes simplex virus was determined in cultured Potoroo (a marsupial) and human cells under lighting conditions which promoted photereactivation. Photoreactivation was readily demonstrated for herpes virus in two lines of Potoroo cells with dose reduction factors of 0.7 to 0.8 for ovary cells and 0.5 to 0.7 for kidney cells. Light from Blacklite (near UV) lamps was more effective than from Daylight (mostly visible) lamps, suggesting that near UV radiation was more effecient for photoreactivation in Potoroo cells. The quantitative and qualitative aspects of this photoreactivation were similar to those reported for a similar virus infecting chick embryo cells. UV-survival curves of herpes virus in Potoroo cells indicated a high level of 'dark' host cell reactivation. No photoreactivation was found for UV-irradiated vaccinia virus in Potoroo cells. A similar photoreactivation study was done using special control lighting (lambda>600 nm) and human cells with normal repair and with cells deficient in excision repair (XP). No photoreactivation was found for UV-irradiated herpes virus in either human cell with either Blacklite or Daylight lamps as the sources of photoreactivating light. This result contrasts with a report of photoreactivation for a herpes virus in the same XP cells using incandescent lamps. (author)

Mycobacteria and innate cells

Indian Academy of Sciences (India)

PRAKASH KUMAR G

Effective adaptive immune responses to pathogenic and ... Protective immunity against mycobacterial infections such as Mycobacterium tuberculosis is mediated by interactions ..... 4. γδ T cells as special guests in the antimycobacterial.

Control mechanisms of cell proliferation in intestinal epithelium

NARCIS (Netherlands)

R.P.C. Rijke (Rudy)

1977-01-01

textabstractIn the adult organism some organs and tissues still contain proliferating and differentiating cells, whereas other organs only consist of non-dividing specialized cells. On the basis of their proliferative activity cell populations may be classified into three categories (135, 138,208).

Factors That Drive Youth Specialization.

Science.gov (United States)

Padaki, Ajay S; Popkin, Charles A; Hodgins, Justin L; Kovacevic, David; Lynch, Thomas Sean; Ahmad, Christopher S

Specialization in young athletes has been linked to overuse injuries, burnout, and decreased satisfaction. Despite continued opposition from the medical community, epidemiological studies suggest the frequency is increasing. Extrinsic pressures in addition to individual aspirations drive this national trend in sports specialization. Descriptive epidemiology study. Level 3. A novel instrument assessing the driving factors behind youth specialization was generated by an interdisciplinary team of medical professionals. Surveys were administered to patients and athletes in the department's sports medicine clinic. The survey was completed by 235 athletes between 7 and 18 years of age, with a mean age of 13.8 ± 3.0 years. Athletes specialized at a mean age of 8.1 years, and 31% of athletes played a single sport while 58% played multiple sports but had a preferred sport. More than 70% of athletes had collegiate or professional ambitions, and 60% played their primary sport for 9 or more months per year, with players who had an injury history more likely to play year-round ( P specialized athletes reporting this significantly more often ( P = 0.04). Half of the athletes reported that sports interfered with their academic performance, with older players stating this more frequently ( P specializing in a single sport before starting high school. While intrinsic drive may identify healthy aspirations, extrinsic influences are prevalent in specialized athletes. Extrinsic factors contributing to youth specialization were identified and compounded the deleterious sequelae of youth athlete specialization.

The Online Specialization Problem

Directory of Open Access Journals (Sweden)

Ed Hong

2006-01-01

Full Text Available We study the online specialization problem, where items arrive in an online fashion for processing by one of n different methods. Each method has two costs: a processing cost (paid once for each item processed, and a set-up cost (paid only once, on the method's first use. There are n possible types of items; an item's type determines the set of methods available to process it. Each method has a different degree of specialization. Highly specialized methods can process few item types while generic methods may process all item types. This is a generalization of ski-rental and closely related to the capital investment problem of Y. Azar, Y. Bartal, E. Feuerstein, A. Fiat, S. Leonardi, and A. Rosen. On capital investment. In Algorithmica, 25(1:22-36, 1999. We primarily study the case where method i+1 is always more specialized than method i and the set-up cost for a more specialized method is always higher than that of a less specialized method. We describe an algorithm with competitive ratio O(log(n, and also show an Ω(log(n lower bound on the competitive ratio for this problem; this shows our ratio is tight up to constant factors.

Sport Specialization, Part I

Science.gov (United States)

Myer, Gregory D.; Jayanthi, Neeru; Difiori, John P.; Faigenbaum, Avery D.; Kiefer, Adam W.; Logerstedt, David; Micheli, Lyle J.

2015-01-01

Context: There is increased growth in sports participation across the globe. Sports specialization patterns, which include year-round training, participation on multiple teams of the same sport, and focused participation in a single sport at a young age, are at high levels. The need for this type of early specialized training in young athletes is currently under debate. Evidence Acquisition: Nonsystematic review. Study Design: Clinical review. Level of Evidence: Level 4. Conclusion: Sports specialization is defined as year-round training (greater than 8 months per year), choosing a single main sport, and/or quitting all other sports to focus on 1 sport. Specialized training in young athletes has risks of injury and burnout, while the degree of specialization is positively correlated with increased serious overuse injury risk. Risk factors for injury in young athletes who specialize in a single sport include year-round single-sport training, participation in more competition, decreased age-appropriate play, and involvement in individual sports that require the early development of technical skills. Adults involved in instruction of youth sports may also put young athletes at risk for injury by encouraging increased intensity in organized practices and competition rather than self-directed unstructured free play. Strength-of-Recommendation Taxonomy (SORT): C. PMID:26502420

Abstract specialization and its applications

OpenAIRE

Puebla Sánchez, Alvaro Germán; Hermenegildo, Manuel V.

2003-01-01

The aim of program specialization is to optimize programs by exploiting certain knowledge about the context in which the program will execute. There exist many program manipulation techniques which allow specializing the program in different ways. Among them, one of the best known techniques is partial evaluation, often referred to simply as program specialization, which optimizes programs by specializing them for (partially) known input data. In this work we describe abstract specia...

Estratégias anatômicas foliares de treze espécies de Orchidaceae ocorrentes em um campo de altitude no Parque Estadual da Serra do Brigadeiro (PESB: MG, Brasil Strategies anatomy from thirteen Orchidaceae species occurring in a "high altitude grasslands" in the State Park of Serra do Brigadeiro (PESB: Minas Gerais State, Brazil

Directory of Open Access Journals (Sweden)

Ivone Vieira da Silva

2006-09-01

the interpretation of adaptative strategies of these species. The species studied were all terrestrial plants except Pleurothallis teres Lindl. that occurring on granitic rock living in extremely conditions. Observations made in adaptative anatomic features showed that two different groups can be easily distinguished: perennial species (Epidendrum secundum Jacq., Epidendrum xanthinum Lindl., Oncidium barbaceniae Lindl., Oncidium blancheti Rchb. F., Pleurothallis prolifera Lindl., Pleurothallis teres Lindl., Zygopetalum brackypetalum Lindl. and Zygopetalum mackaii Hook., and species with reduced aerial parts during drought periods (Cleistes gracilis Schdl., Habenaria hydrophila Barb. Rodr., Habenaria janeirensis Kraenzl, Habenaria macronectar Hoehne and Prescottia montana Barb. Rodr.. The perennial species showed xeromorphic features such as coriaceous or coriaceous-succulent leaves, thick striated cuticle, hypodermis, groups of fibers dispersed into a homogenous mesophyll, aquiferous parenchyma with bars or helical thichenings in the walls, rafid idioblasts and colateral vascular bundles surrounded by groups of fibers. In the species with reduced aerial parts different investments were observed and the xeromorphic features were not stressed. These leaves were thin and showed high adaxial epidermal cells having smooth cuticle and rafid idioblasts present in the mesophyll. No hypodermis was identified and the vascular bundles were reduced without rafid idioblasts with them.

Special requirements for bolting material for nuclear and other special applications

International Nuclear Information System (INIS)

Anon.

1981-01-01

A specification that provides special requirements for bolting material for use in nuclear and other special applications is presented. The requirements of the specification are supplemental to the requirements of the basic material specifications and they include tempering, welding, elimination of surface defects, certification and identification, quality assurance and various examination methods

Sports Specialization in Young Athletes

OpenAIRE

Jayanthi, Neeru; Pinkham, Courtney; Dugas, Lara; Patrick, Brittany; LaBella, Cynthia

2013-01-01

Context: Sports specialization is intense training in 1 sport while excluding others. Sports specialization in early to middle childhood has become increasingly common. While most experts agree that some degree of sports specialization is necessary to achieve elite levels, there is some debate as to whether such intense practice time must begin during early childhood and to the exclusion of other sports to maximize potential for success. There is a concern that sports specialization before ad...

Special Operations Doctrine: Is it Needed

Science.gov (United States)

2016-12-07

AOB), eight Special Forces Operational Detachment-Alphas (SFODAs)2, and Civil Affairs and Psychological Operations teams working alongside two bat...Operations doctrine. Sixty years after the Army’s first special operations units were formed, the time had arrived for writing how Army special operations...Affairs, Psychological Operations, and Special Forces, the effort inte- grated the roles and missions of the Ranger Regiment, Special Mission Units, and

Targeting the BCR signalosome in B cell malignancies

NARCIS (Netherlands)

de Rooij, M.F.M.

2017-01-01

Chronic lymphocytic leukemia (CLL), mantle cell lymphoma (MCL), and Waldenström macroglobulinemia (WM) are B-cell malignancies which are still incurable. In these lymphomas, the cells proliferate in specialized niches in lymph nodes and bone marrow, in which they are provided by stromal-derived

Fate of tumor cells injected into left ventricle of heart in BALB/c mice: role of natural killer cells

DEFF Research Database (Denmark)

Basse, P; Hokland, P; Heron, I

1988-01-01

The arrest, retention, and elimination (i.e., clearance) of radiolabeled YAC-1 lymphoma cells injected either iv or into the left ventricle (LV) of the heart were studied in male BALB/c mice, with special emphasis on the role of natural killer (NK) cells. After iv injection YAC-1 cells were...

Towards unifying inheritance and automatic program specialization

DEFF Research Database (Denmark)

Schultz, Ulrik Pagh

2002-01-01

with covariant specialization to control the automatic application of program specialization to class members. Lapis integrates object-oriented concepts, block structure, and techniques from automatic program specialization to provide both a language where object-oriented designs can be e#ciently implemented......Inheritance allows a class to be specialized and its attributes refined, but implementation specialization can only take place by overriding with manually implemented methods. Automatic program specialization can generate a specialized, effcient implementation. However, specialization of programs...

Trends in Special Library Buildings.

Science.gov (United States)

Cohen, Elaine; Cohen, Aaron

1987-01-01

Examines special library facilities, noting impact of organizational structure, and discusses the concept of information resources management in this context. Development of online and telecommunications systems, corporate and government campuses, and special library systems are identified as reasons for growth of special libraries. Furniture and…

75 FR 55786 - Office of Special Education Programs, Office of Special Education and Rehabilitative Services...

Science.gov (United States)

2010-09-14

... DEPARTMENT OF EDUCATION Office of Special Education Programs, Office of Special Education and Rehabilitative Services, Department of Education; Notice of Final Extension of Project Period and Waiver for the... Transition Technical Assistance Center (NSTTAC). Currently, the Office of Special Education Programs (OSEP...

Double-bouquet cells in the monkey and human cerebral cortex with special reference to areas 17 and 18.

Science.gov (United States)

DeFelipe, Javier; Ballesteros-Yáñez, Inmaculada; Inda, Maria Carmen; Muñoz, Alberto

2006-01-01

The detailed microanatomical study of the human cerebral cortex began in 1899 with the experiments of Santiago Ramón y Cajal, who applied the Golgi method to define the structure of the visual, motor, auditory and olfactory cortex. In the first article of this series, he described a special type of interneuron in the visual cortex capable of exerting its influence in the vertical dimension. These neurons are now more commonly referred to as double-bouquet cells (DBCs). The DBCs are readily distinguished owing to their characteristic axons that give rise to tightly interwoven bundles of long, vertically oriented axonal collaterals resembling a horsetail (DBC horsetail). Nevertheless, the most striking characteristic of these neurons is that they are so numerous and regularly distributed that the DBC horsetails form a microcolumnar structure. In addition, DBCs establish hundreds of inhibitory synapses within a very narrow column of cortical tissue. These features have generated considerable interest in DBCs over recent years, principally among those researchers interested in the analysis of cortical circuits. In the present chapter, we shall discuss the morphology, synaptic connections and neurochemical features of DBCs that have been defined through the study of these cells in different cortical areas and species. We will mainly consider the immunocytochemical studies of DBCs that have been carried out in the visual cortex (areas 17 and 18) of human and macaque monkey. We will see that there are important differences in the morphology, number and distribution of DBC horsetails between areas 17 and 18 in the primate. This suggests important differences in the microcolumnar organization between these areas, the functional significance of which awaits detailed correlative physiological and microanatomical studies.

Bentonite-amended soils special study

International Nuclear Information System (INIS)

1990-10-01

This report presents the results of a two-phased special study to evaluate the viability of soil amended with a high percentage of bentonite as an infiltration barrier in the cover of Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cells. Phase I of the study was initiated in order to examine the feasibility of using bentonite-amended soils as a cover component on sideslopes and topslopes. The Phase I objectives were to test a variety of materials to determine if low hydraulic conductivities were achievable in materials exhibiting sufficient strength and to select suitable materials for further testing. Phase II objectives were to (1) optimize designs -- test materials with various percentages of bentonite added; (2) provide design recommendations; (3) address constructibility concerns; and (4) evaluate long-term performance with respect to desiccation effects on the amended materials

Special Issue to publish

OpenAIRE

Kllogjeri, Pellumb

2015-01-01

SciencePG has offered an email poster to help collect papers for our Special Issue and I have uploaded it for you. Please visit http://www.sciencepublishinggroup.com/specialissue/149002  to see our Special Issue announcement. Now, you can do the followings to personally contribute and promote our Special Issue:1. Submit your paper related to the topics of interest 2. Upload it to your personal websites.3. Upload it to the public websites of some universities and academic institutions...

Neuroendocrine cells during human prostate development: does neuroendocrine cell density remain constant during fetal as well as postnatal life?

NARCIS (Netherlands)

Xue, Y.; van der Laak, J.; Smedts, F.; Schoots, C.; Verhofstad, A.; de la Rosette, J.; Schalken, J.

2000-01-01

Knowledge concerning differentiation of neuroendocrine (NE) cells during development of the human prostate is rather fragmentary. Using immunohistochemistry combined with a morphometric method, we investigated the distribution and density of NE cells in the developing human prostate, with special

75 FR 55785 - Office of Special Education Programs, Office of Special Education and Rehabilitative Services...

Science.gov (United States)

2010-09-14

... DEPARTMENT OF EDUCATION Office of Special Education Programs, Office of Special Education and Rehabilitative Services, Department of Education; Notice of Final Extension of Project Period and Waiver for the... this award, the Office of Special Education Programs (OSEP) funds NCEO to address national, State, and...

Replication Research and Special Education

Science.gov (United States)

Travers, Jason C.; Cook, Bryan G.; Therrien, William J.; Coyne, Michael D.

2016-01-01

Replicating previously reported empirical research is a necessary aspect of an evidence-based field of special education, but little formal investigation into the prevalence of replication research in the special education research literature has been conducted. Various factors may explain the lack of attention to replication of special education…

Ohio Special Education Profile, 2011

Science.gov (United States)

Ohio Coalition for the Education of Children with Disabilities, 2011

2011-01-01

This report provides a brief, but substantive, profile of the special needs student population in Ohio, including academic performance and graduation trends and an overview of special education funding and related policy issues. The report's central message is that investments in students with special educational needs produce substantial results…

Pea border cell maturation and release involve complex cell wall structural dynamics

DEFF Research Database (Denmark)

Mravec, Jozef; Guo, Xiaoyuan; Hansen, Aleksander Riise

2017-01-01

The adhesion of plant cells is vital for support and protection of the plant body and is maintained by a variety of molecular associations between cell wall components. In some specialized cases though, plant cells are programmed to detach and root cap-derived border cells are examples of this....... Border cells (in some species known as border-like cells) provide an expendable barrier between roots and the environment. Their maturation and release is an important but poorly characterized cell separation event. To gain a deeper insight into the complex cellular dynamics underlying this process, we...... undertook a systematic, detailed analysis of pea (Pisum sativum) root tip cell walls. Our study included immuno-carbohydrate microarray profiling, monosaccharide composition determination, Fourier-transformed infrared microspectroscopy (FT-IR), quantitative RT-PCR of cell wall biosynthetic genes, analysis...

Neurogenic transdifferentiation of human adipose-derived stem cells? A critical protocol reevaluation with special emphasis on cell proliferation and cell cycle alterations.

Science.gov (United States)

Kompisch, Kai Michael; Lange, Claudia; Steinemann, Doris; Skawran, Britta; Schlegelberger, Brigitte; Müller, Reinhard; Schumacher, Udo

2010-11-01

Adipose-derived stem cells (ASCs) are reported to display multilineage differentiation potential, including neuroectodermal pathways. The aim of the present study was to critically re-evaluate the potential neurogenic (trans-)differentiation capacity of ASCs using a neurogenic induction protocol based on the combination of isobutylmethylxanthine (IBMX), indomethacin and insulin. ASCs isolated from lipo-aspirate samples of five healthy female donors were characterized and potential neurogenic (trans-)differentiation was assessed by means of immunohistochemistry and gene expression analyses. Cell proliferation and cell cycle alterations were studied, and the expression of CREB/ATF transcription factors was analyzed. ASCs expressed CD59, CD90 and CD105, and were tested negative for CD34 and CD45. Under neurogenic induction, ASCs adopted a characteristic morphology comparable to neur(on)al progenitors and expressed musashi1, β-III-tubulin and nestin. Gene expression analyses revealed an increased expression of β-III-tubulin, GFAP, vimentin and BDNF, as well as SOX4 in induced ASCs. Cell proliferation was significantly reduced under neurogenic induction; cell cycle analyses showed a G2-cell cycle arrest accompanied by differential expression of key regulators of cell cycle progression. Differential expression of CREB/ATF transcription factors could be observed on neurogenic induction, pointing to a decisive role of the cAMP-CREB/ATF system. Our findings may point to a potential neurogenic (trans-)differentiation of ASCs into early neur(on)al progenitors, but do not present definite evidence for it. Especially, the adoption of a neural progenitor cell-like morphology must not automatically be misinterpreted as a specific characteristic of a respective (trans-)differentiation process, as this may as well be caused by alterations of cell cycle progression.

Virtual Reality and Special Needs

Science.gov (United States)

Jeffs, Tara L.

2009-01-01

The use of virtual environments for special needs is as diverse as the field of Special Education itself and the individuals it serves. Individuals with special needs often face challenges with attention, language, spatial abilities, memory, higher reasoning and knowledge acquisition. Research in the use of Virtual Learning Environments (VLE)…

Special Issue: International Congress of Cell Biology 2016, Prague

Czech Academy of Sciences Publication Activity Database

Stick, R.; Dráber, Pavel

2017-01-01

Roč. 254, č. 3 (2017), s. 1141-1142 ISSN 0033-183X R&D Projects: GA ČR GA16-25159S Institutional support: RVO:68378050 Keywords : cellular structures and functions, ,, , * tubulin isotypes * actin * transcription regulation * signaling pathways Subject RIV: EB - Genetics ; Molecular Biology OBOR OECD: Cell biology Impact factor: 2.870, year: 2016

Special Education in Nigeria.

Science.gov (United States)

Abang, Theresa B.

1992-01-01

This article discusses the special education system in Nigeria, focusing on integration; training of special educators; medical, health, and welfare services for children with disabilities; recreational facilities; employment opportunities; national planning; and problems and successes. (JDD)

Development of special libraries in Slovenia

Directory of Open Access Journals (Sweden)

Nada Češnovar

2002-01-01

Full Text Available Although Slovenia is a small European country with only 2 million inhabitants, Slovenian librarianship can be compared with any other bigger country. The staffing and information technology in special libraries have been accelerating for the last four decades.Seventeen years have passed since the first meeting of special libraries. When Slovenia attained independence, numerous changes occured in the field of special librarianship.Due to the economic crisis, several special libraries of enterprises were abolished, while on the other hand, the number of special libraries in public institutions has increased. The article deals with the changes which have influenced the development of special librarianship in Slovenia.

Research Article Special Issue

African Journals Online (AJOL)

pc

2018-03-07

Mar 7, 2018 ... characterized by historically developed specialization, a special geographical location ... We are listed under Research Associations category. ... product, service or technology providing economic and/or public benefit, additional in ...... the region's competitiveness // International Business Management.

Merging Regular and Special Education Teacher Preparation Programs: The Integrated Special Education-English Project (ISEP).

Science.gov (United States)

Miller, Darcy E.

1991-01-01

Describes the Integrated Special Education-English Project (ISEP) which facilitated the gradual integration of special education and English teacher preparation programs. A description of the ISEP model and a case study are included. The case study indicated student teachers who participated in the ISEP improved special education and English…

Functional specialization and evolution of leader proteinases in the family Closteroviridae.

Science.gov (United States)

Peng, C W; Peremyslov, V V; Mushegian, A R; Dawson, W O; Dolja, V V

2001-12-01

Members of the Closteroviridae and Potyviridae families of the plant positive-strand RNA viruses encode one or two papain-like leader proteinases. In addition to a C-terminal proteolytic domain, each of these proteinases possesses a nonproteolytic N-terminal domain. We compared functions of the several leader proteinases using a gene swapping approach. The leader proteinase (L-Pro) of Beet yellows virus (BYV; a closterovirus) was replaced with L1 or L2 proteinases of Citrus tristeza virus (CTV; another closterovirus), P-Pro proteinase of Lettuce infectious yellows virus (LIYV; a crinivirus), and HC-Pro proteinase of Tobacco etch virus (a potyvirus). Each foreign proteinase efficiently processed the chimeric BYV polyprotein in vitro. However, only L1 and P-Pro, not L2 and HC-Pro, were able to rescue the amplification of the chimeric BYV variants. The combined expression of L1 and L2 resulted in an increased RNA accumulation compared to that of the parental BYV. Remarkably, this L1-L2 chimera exhibited reduced invasiveness and inability to move from cell to cell. Similar analyses of the BYV hybrids, in which only the papain-like domain of L-Pro was replaced with those derived from L1, L2, P-Pro, and HC-Pro, also revealed functional specialization of these domains. In subcellular-localization experiments, distinct patterns were observed for the leader proteinases of BYV, CTV, and LIYV. Taken together, these results demonstrated that, in addition to a common proteolytic activity, the leader proteinases of closteroviruses possess specialized functions in virus RNA amplification, virus invasion, and cell-to-cell movement. The phylogenetic analysis suggested that functionally distinct L1 and L2 of CTV originated by a gene duplication event.

Keeping stem cells under control: new insights into the mechanisms that limit niche-stem cell signaling within the reproductive system

OpenAIRE

Inaba, Mayu; Yamashita, Yukiko M.; Buszczak, Michael

2016-01-01

Adult stem cells reside in specialized microenvironments called niches that maintain stem cells in an undifferentiated and self-renewing state. Despite extensive studies on the signaling pathways that operate within stem cells and their niches, the mechanisms that restrict niche signal exclusively to stem cells remained elusive: such a mechanism is crucially important to ensure that stem cells undergo self-renewal while their progeny, often located just one cell diameter away from the niche, ...

The relationship between hospital specialization and hospital efficiency: do different measures of specialization lead to different results?

Science.gov (United States)

Lindlbauer, Ivonne; Schreyögg, Jonas

2014-12-01

This study investigated the relationship between hospital specialization and technical efficiency using different measures of specialization, including two novel approaches based on patient volumes rather than patient proportions. It was motivated by the observation that most studies to date have quantified hospital specialization using information about hospital patients grouped into different categories based on their diagnosis, and in doing so have used proportions-thus indirectly assuming that these categories are dependent on one other. In order to account for the diversification of organizations and the idea that hospitals can be specialized in terms of professional expertise or technical equipment within a given diagnosis category, we developed our two specialization measures based on patient volume in each category. Using a one-step stochastic frontier approach on randomly selected data from the annual reports of 1,239 acute care German hospitals for the years 2000 through 2010, we estimated the relationship of inefficiency to exogenous variables, such as specialization. The results show that specialization as quantified by our novel measures has effects on efficiency that are the opposite of those obtained using earlier measures of specialization. These results underscore the importance of always providing an exact definition of specialization when studying its effects. Additionally, a Monte Carlo simulation based on three scenarios is provided to facilitate the choice of a specialization measure for further analysis.

A myogenic precursor cell that could contribute to regeneration in zebrafish and its similarity to the satellite cell.

Science.gov (United States)

Siegel, Ashley L; Gurevich, David B; Currie, Peter D

2013-09-01

The cellular basis for mammalian muscle regeneration has been an area of intense investigation over recent decades. The consensus is that a specialized self-renewing stem cell, termed the satellite cell, plays a major role during the process of regeneration in amniotes. How broadly this mechanism is deployed within the vertebrate phylogeny remains an open question. A lack of information on the role of cells analogous to the satellite cell in other vertebrate systems is even more unexpected given the fact that satellite cells were first designated in frogs. An intriguing aspect of this debate is that a number of amphibia and many fish species exhibit epimorphic regenerative processes in specific tissues, whereby regeneration occurs by the dedifferentiation of the damaged tissue, without deploying specialized stem cell populations analogous to satellite cells. Hence, it is feasible that a cellular process completely distinct from that deployed during mammalian muscle regeneration could operate in species capable of epimorphic regeneration. In this minireview, we examine the evidence for the broad phylogenetic distribution of satellite cells. We conclude that, in the vertebrates examined so far, epimorphosis does not appear to be deployed during muscle regeneration, and that analogous cells expressing similar marker genes to satellite cells appear to be deployed during the regenerative process. However, the functional definition of these cells as self-renewing muscle stem cells remains a final hurdle to the definition of the satellite cell as a generic vertebrate cell type. © 2013 FEBS.

The Emerging Cell Biology of Thyroid Stem Cells

Science.gov (United States)

Latif, Rauf; Minsky, Noga C.; Ma, Risheng

2011-01-01

Context: Stem cells are undifferentiated cells with the property of self-renewal and give rise to highly specialized cells under appropriate local conditions. The use of stem cells in regenerative medicine holds great promise for the treatment of many diseases, including those of the thyroid gland. Evidence Acquisition: This review focuses on the progress that has been made in thyroid stem cell research including an overview of cellular and molecular events (most of which were drawn from the period 1990–2011) and discusses the remaining problems encountered in their differentiation. Evidence Synthesis: Protocols for the in vitro differentiation of embryonic stem cells, based on normal developmental processes, have generated thyroid-like cells but without full thyrocyte function. However, agents have been identified, including activin A, insulin, and IGF-I, which are able to stimulate the generation of thyroid-like cells in vitro. In addition, thyroid stem/progenitor cells have been identified within the normal thyroid gland and within thyroid cancers. Conclusions: Advances in thyroid stem cell biology are providing not only insight into thyroid development but may offer therapeutic potential in thyroid cancer and future thyroid cell replacement therapy. PMID:21778219

de Sitter special relativity

International Nuclear Information System (INIS)

Aldrovandi, R; Almeida, J P Beltran; Pereira, J G

2007-01-01

A special relativity based on the de Sitter group is introduced, which is a theory that might hold up in the presence of a non-vanishing cosmological constant. Like ordinary special relativity, it retains the quotient character of spacetime, and a notion of homogeneity. As a consequence, the underlying spacetime will be a de Sitter spacetime, whose associated kinematics will differ from that of ordinary special relativity. The corresponding modified notions of energy and momentum are obtained, and the exact relationship between them, which is invariant under a re-scaling of the involved quantities, explicitly exhibited. Since the de Sitter group can be considered a particular deformation of the Poincare group, this theory turns out to be a specific kind of deformed (or doubly) special relativity. Some experimental consequences, as well as the causal structure of spacetime-modified by the presence of the de Sitter horizon-are briefly discussed

“What’s So Special about Special Collections?” Or, Assessing the Value Special Collections Bring to Academic Libraries

Directory of Open Access Journals (Sweden)

Elizabeth Yakel

2013-06-01

Full Text Available Objective – The objective of this study was to examine and call attention to the current deficiency in standardized performance measures and usage metrics suited to assessing the value and impact of special collections and archives and their contributions to the mission of academic research libraries and to suggest possible approaches to overcoming the deficiency.Methods – The authors reviewed attempts over the past dozen years by the Association of Research Libraries (ARL and the Association of College and Research Libraries (ACRL to highlight the unique types of value that special collections and archival resources contribute to academic research libraries. They also examined the results of a large survey of special collections and archives conducted by OCLC Research in 2010. In addition, they investigated efforts by the Society of American Archivists (SAA dating back to the 1940s to define standardized metrics for gathering and comparing data about archival operations. Finding that the library and archival communities have thus far failed to develop and adopt common metrics and methods for gathering data about the activities of special collections and archives, the authors explored the potential benefits of borrowing concepts for developing user-centered value propositions and metrics from the business community.Results – This study found that there has been a lack of consensus and precision concerning the definition of “special collections” and the value propositions they offer, and that most attempts have been limited in their usefulness because they were collections-centric. The study likewise reaffirmed a lack of consensus regarding how to define and measure basic operations performed by special collections and archives, such as circulating materials to users in supervised reading rooms. The review of concepts and metrics for assessing value in the business community, however, suggested new approaches to defining metrics that

[Progress in epidermal stem cells].

Science.gov (United States)

Wang, Li-Juan; Wang, You-Liang; Yang, Xiao

2010-03-01

Mammalian skin epidermis contains different epidermal stem cell pools which contribute to the homeostasis and repair of skin epithelium. Epidermal stem cells possess two essential features common to all stem cells: self-renewal and differentiation. Disturbing the balance between self-renewal and differentiation of epidermal stem cell often causes tumors or other skin diseases. Epidermal stem cell niches provide a special microenvironment that maintains a balance of stem cell quiescence and activity. This review primarily concentrates on the following points of the epidermal stem cells: the existing evidences, the self-renewal and differentiation, the division pattern, the signal pathways regulating self-renewal and differentiation, and the microenvironment (niche) and macroenvironment maintaining the homeostasis of stem cells.

Special Needs: Planning for Adulthood (Videos)

Medline Plus

Full Text Available ... Videos for Educators Search English Español Special Needs: Planning for Adulthood (Video) KidsHealth / For Parents / Special Needs: Planning for Adulthood (Video) Print Young adults with special ...

Building Management Systems and Domotics. Special issue; Gebouwautomatisering en Domotica. Special

Energy Technology Data Exchange (ETDEWEB)

Rigter, L.; Dekker, P.; Knipscheer, R.; Veenema, R.; Vlietstra, E. [Siemens Building Technologies, Zuerich (Switzerland); Symanczik, H.; Van Houwelingen, P. [Kieback en Peter Nederland, Nunspeet (Netherlands); Van Grieken, K. [Priva Building Intelligence, Delft (Netherlands); De Koning, G. [Regel Partners, Hoevelaken (Netherlands); Hitzert, L.A. [Honeywell, Amsterdam (Netherlands); Uythof, B.H. [Domotica Platform Nederland, Amsterdam (Netherlands); Wortel, W. [Kropman, Rijswijk (Netherlands); Zeiler, W. [Faculteit Bouwkunde - FAGO, Technische Universiteit Eindhoven, Eindhoven (Netherlands); Kamphuis, I.G. [Energieonderzoek Centrum Nederland ECN, Petten (Netherlands); Akkermans, J.M. [Vrije Universiteit, Amsterdam (Netherlands)

2002-05-01

In 12 articles an overview is given of developments in the use of automation and domotics in different types of buildings. Previous specials on the same subject in this magazine were published in november 1989, november 1995 and december 1999. [Dutch] In 12 artikelen wordt uitgebreid aandacht besteed aan ontwikkelingen in gebouwautomatisering en domotica. Eerdere specials over dit onderwerp werden uitgebracht in november 1989, november 1995 en december 1999.

Special theory of relativity

CERN Document Server

Kilmister, Clive William

1970-01-01

Special Theory of Relativity provides a discussion of the special theory of relativity. Special relativity is not, like other scientific theories, a statement about the matter that forms the physical world, but has the form of a condition that the explicit physical theories must satisfy. It is thus a form of description, playing to some extent the role of the grammar of physics, prescribing which combinations of theoretical statements are admissible as descriptions of the physical world. Thus, to describe it, one needs also to describe those specific theories and to say how much they are limit

Wicked Problems in Special and Inclusive Education

Science.gov (United States)

Armstrong, David

2017-01-01

This special paper provides a critical overview of wicked problems in special and inclusive education. Practically, this paper provides a strategic framework for future special issues in the "Journal of Special Educational Needs". Critical attention is also given to the concept of a wicked problem when applied to research in special and…

Mass spectrometric characterization of elements and molecules in cell cultures and tissues

International Nuclear Information System (INIS)

Arlinghaus, H.F.; Kriegeskotte, C.; Fartmann, M.; Wittig, A.; Sauerwein, W.; Lipinsky, D.

2006-01-01

Time-of-flight secondary ion mass spectrometry (ToF-SIMS) and laser post-ionization secondary neutral mass spectrometry (laser-SNMS) have been used to image and quantify targeted compounds, intrinsic elements and molecules with subcellular resolution in single cells of both cell cultures and tissues. Special preparation procedures for analyzing cell cultures and tissue materials were developed. Cancer cells type MeWo, incubated with boronated compounds, were sandwiched between two substrates, cryofixed, freeze-fractured and freeze-dried. Also, after injection with boronated compounds, different types of mouse tissues were extracted, prepared on a special specimen carrier and plunged with high velocity into LN 2 -cooled propane for cryofixation. After trimming, these tissue blocks were freeze-dried. The measurements of the K/Na ratio demonstrated that for both cell cultures and tissue materials the special preparation techniques used were appropriate for preserving the chemical and structural integrity of the living cell. The boron images show inter- and intracellular boron signals with different intensities. Molecular images show distinct features partly correlated with the cell structure. A comparison between laser-SNMS and ToF-SIMS showed that especially laser-SNMS is particularly well-suited for identifying specific cell structures and imaging ultratrace element concentrations in tissues

Glial origin of mesenchymal stem cells in a tooth model system

NARCIS (Netherlands)

Kaukua, Nina; Shahidi, Maryam Khatibi; Konstantinidou, Chrysoula; Dyachuk, Vyacheslav; Kaucka, Marketa; Furlan, Alessandro; An, Zhengwen; Wang, Longlong; Hultman, Isabell; Ahrlund-Richter, Lars; Blom, Hans; Brismar, Hjalmar; Lopes, Natalia Assaife; Pachnis, Vassilis; Suter, Ueli; Clevers, Hans; Thesleff, Irma; Sharpe, Paul; Ernfors, Patrik; Fried, Kaj; Adameyko, Igor

2014-01-01

Mesenchymal stem cells occupy niches in stromal tissues where they provide sources of cells for specialized mesenchymal derivatives during growth and repair. The origins of mesenchymal stem cells have been the subject of considerable discussion, and current consensus holds that perivascular cells

Special Weapons

Data.gov (United States)

Federal Laboratory Consortium — Supporting Navy special weapons, the division provides an array of engineering services, technical publication support services, logistics support services, safety...

Introduction to solar cell production

International Nuclear Information System (INIS)

Kim, Gyeong Hae; Lee, Jun Sin

2009-08-01

This book introduces solar cell production. It is made up eight chapters, which are summary of solar cell with structure and prospect of the business, special variable of solar cell on light of the sun and factor causing variable of solar cell, production of solar cell with surface texturing, diffusion, metal printing dry and firing and edge isolation, process of solar cell on silicone wafer for solar cell, forming of electrodes, introduction of thin film solar cell on operating of solar cell, process of production and high efficiency of thin film solar cell, sorting of solar cell and production with background of silicone solar cell and thin film solar cell, structure and production of thin film solar cell and compound solar cell, introduction of solar cell module and the Industrial condition and prospect of solar cell.

Special polynomials associated with some hierarchies

International Nuclear Information System (INIS)

Kudryashov, Nikolai A.

2008-01-01

Special polynomials associated with rational solutions of a hierarchy of equations of Painleve type are introduced. The hierarchy arises by similarity reduction from the Fordy-Gibbons hierarchy of partial differential equations. Some relations for these special polynomials are given. Differential-difference hierarchies for finding special polynomials are presented. These formulae allow us to obtain special polynomials associated with the hierarchy studied. It is shown that rational solutions of members of the Schwarz-Sawada-Kotera, the Schwarz-Kaup-Kupershmidt, the Fordy-Gibbons, the Sawada-Kotera and the Kaup-Kupershmidt hierarchies can be expressed through special polynomials of the hierarchy studied

Special Needs: Planning for Adulthood (Videos)

Medline Plus

Full Text Available ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know (Special Needs Glossary) View more About Us Contact Us Partners Editorial Policy Permissions Guidelines Privacy ...

A review on stem cell therapy for multiple sclerosis: special focus on human embryonic stem cells.

Science.gov (United States)

Shroff, Geeta

2018-01-01

Multiple sclerosis (MS), a complex disorder of the central nervous system (CNS), is characterized with axonal loss underlying long-term progressive disability. Currently available therapies for its management are able to slow down the progression but fail to treat it completely. Moreover, these therapies are associated with major CNS and cardiovascular adverse events, and prolonged use of these treatments may cause life-threatening diseases. Recent research has shown that cellular therapies hold a potential for CNS repair and may be able to provide protection from inflammatory damage caused after injury. Human embryonic stem cell (hESC) transplantation is one of the promising cell therapies; hESCs play an important role in remyelination and help in preventing demylenation of the axons. In this study, an overview of the current knowledge about the unique properties of hESC and their comparison with other cell therapies has been presented for the treatment of patients with MS.

Keeping the Rhythm : Cardiac Pacemaker Cell Development

NARCIS (Netherlands)

Burkhard, S.B.

2017-01-01

The heart is the first organ to form and function in the developing vertebrate embryo. Its proper morphogenesis and function is crucial for survival. Here we focus on the development and characterization of a highly specialized subset of cardiac cells, the pacemaker cells. In the mammalian heart,

Anatomia de raízes de nove espécies de Bromeliaceae (Poales da região amazônica do estado de Mato Grosso, Brasil Anatomy of the roots of nine species of Bromeliaceae (Poales from the Amazon, Mato Grosso, Brazil

Directory of Open Access Journals (Sweden)

Ivone Vieira da Silva

2011-09-01

endodermis and pericycle, polyarch vascular cylinder and medulla with thickened cell walls. Anatomical structures, such as the number of layers and kind of cell wall thickening of the velamen, the kind of thickening of the exodermis and endodermis walls, the presence of idioblasts containing crystals and the number of protoxylem poles help seperate these species within different genera and subfamilies. The presence of mucilage canals in the cortex of A. castelnavii is a diagnostic feature. The roots of Dyckia and Tillandsia share more common features, so there is greater similarity between Pitcairnioideae and Tillandsioideae. Roots with velamen, an exodermis with thickened cell walls constituting a mechanical layer, mucilage canals, air gaps in the inner cortex and idioblasts with crystals are structures adapted to the epiphytic habit.

Single cell transcriptome profiling of developing chick retinal cells.

Science.gov (United States)

Laboissonniere, Lauren A; Martin, Gregory M; Goetz, Jillian J; Bi, Ran; Pope, Brock; Weinand, Kallie; Ellson, Laura; Fru, Diane; Lee, Miranda; Wester, Andrea K; Liu, Peng; Trimarchi, Jeffrey M

2017-08-15

The vertebrate retina is a specialized photosensitive tissue comprised of six neuronal and one glial cell types, each of which develops in prescribed proportions at overlapping timepoints from a common progenitor pool. While each of these cells has a specific function contributing to proper vision in the mature animal, their differential representation in the retina as well as the presence of distinctive cellular subtypes makes identifying the transcriptomic signatures that lead to each retinal cell's fate determination and development challenging. We have analyzed transcriptomes from individual cells isolated from the chick retina throughout retinogenesis. While we focused our efforts on the retinal ganglion cells, our transcriptomes of developing chick cells also contained representation from multiple retinal cell types, including photoreceptors and interneurons at different stages of development. Most interesting was the identification of transcriptomes from individual mixed lineage progenitor cells in the chick as these cells offer a window into the cell fate decision-making process. Taken together, these data sets will enable us to uncover the most critical genes acting in the steps of cell fate determination and early differentiation of various retinal cell types. © 2017 Wiley Periodicals, Inc.

[The perichromatin compartment of the cell nucleus].

Science.gov (United States)

Bogoliubov, D S

2014-01-01

In this review, the data on the structure and composition of the perichromatin compartment, a special border area between the condensed chromatin and the interchromatin space of the cell nucleus, are discussed in the light of the concept of nuclear functions in complex nuclear architectonics. Morphological features, molecular composition and functions of main extrachromosomal structures of the perichromatin compartment, perichromatin fibrils (PFs) and perichromatin granules (PGs) including nuclear stress-bodies (nSBs) that are derivates of the PGs under heat shock, are presented. A special attention was paid to the features of the molecular compositions of PFs and PGs in different cell types and at different physiological conditions.

75 FR 33553 - Special Conditions: AeroMech, Incorporated; Hawker Beechcraft Corporation, Model B200 and Other...

Science.gov (United States)

2010-06-14

... circuit of the battery or of its individual cells. (7) Li-ion battery installations must have-- (i) A... charger degradation. (10) Batteries in a rotating stock (spares) that have experienced degraded charge... Battery AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed special conditions...

[Mesenchymal stroma cells and their niche].

Science.gov (United States)

Schneider, R K

2013-11-01

Stem cells reside in a highly specialized, complex microenvironment that is known as the stem cell niche. The stem cell niche can be described as an anatomically defined space where the stem cell is localized and nourished and stem cell quiescence, proliferation and differentiation are maintained. Tissue engineering aims to imitate the stem cell niche to (I) induce a directed differentiation, (II) maintain the self-renewal capacity or (III) find a regulated balance between self-renewal and differentiation. Mesenchymal stem or stromal cells (MSC) can differentiate in three-dimensional collagen gels into functional osteoblasts when subjected to a phosphate-rich cultivation medium. Furthermore, they acquire a prosynthetic, matrix remodeling, contractile phenotype. Medial artery calcification in patients with chronic kidney disease also proceeds through intramembranous ossification resulting from osteoblast-induced calcification of the collagen extracellular matrix. Thus, the influence of uremic cultivation conditions as a pathophysiological stimulus on MSC and endothelial cells was analyzed with special regards to matrix remodeling, vascularization and calcification. The results showed that BMP-2/4 mediated MSC (mal)differentiation into osteoblasts with acquired matrix remodeling phenotype and loss of proangiogenic capacity. These studies have led to the conclusion that uremia has detrimental effects on the stem cell niche and promotes the continuous calcification by osteogenic (mal)differentiation. In summary, recent studies have shown the conducting and regulating effect of the stem cell niche under physiological conditions that can be applied and mimicked for tissue engineering applications. However, under pathological conditions the stem cell niche can have detrimental effects on stem cell function and can promote disease progression.

Is memory for music special?

Science.gov (United States)

Schulkind, Matthew D

2009-07-01

Although psychologists since Hermann Ebbinghaus have studied memory, research in this area has focused on visual and verbal stimuli with little attention paid to music. This bias is surprising because of the ubiquity of music in human cultures across history as well as current cultural beliefs that memory for music is "special." This paper examines the question of whether memory for music is special by addressing two related questions: First, do cultural beliefs about the mnemonic power of music stand up to empirical test? Second, can theories designed to explain memory for non-musical stimuli be applied to musical stimuli? A review of the literature suggests that music is special in some circumstances but not others and that some theories designed to explain cognitive processing of linguistic stimuli apply reasonably well to musical stimuli. Thus, although the question of whether memory for music is special remains open, the unique structure of musical stimuli strongly suggests that memory for music is indeed special.

Dynamics of general and specially trained of women-weightlifters at the stage of specialized basic training

Directory of Open Access Journals (Sweden)

Viktor Slobodyanuk

2015-04-01

Full Text Available Purpose: to determine the dynamics of the general and special training of women-weightlifters different groups weight categories for annual macrocycle at the stage of specialized basic training. Materials and Methods: indexes long jump, running 30 meters, push-ups, jumps on how Abalakova index and wrist strength athletes different schools of Ukraine. Results: found dynamic indicators of general and special training of women-weightlifters different groups weight categories at the stage of basic training six specialized schools in Ukraine. Conclusions: the results of the study provide an opportunity to consider certain indicators in planning differentiated training programs to improve the training process athletes for women-weightlifters at the stage of specialized basic training different groups weight categories in the annual macrocycle.

Sensory Hair Cells: An Introduction to Structure and Physiology.

Science.gov (United States)

McPherson, Duane R

2018-06-18

Sensory hair cells are specialized secondary sensory cells that mediate our senses of hearing, balance, linear acceleration, and angular acceleration (head rotation). In addition, hair cells in fish and amphibians mediate sensitivity to water movement through the lateral line system, and closely related electroreceptive cells mediate sensitivity to low-voltage electric fields in the aquatic environment of many fish species and several species of amphibian.Sensory hair cells share many structural and functional features across all vertebrate groups, while at the same time they are specialized for employment in a wide variety of sensory tasks. The complexity of hair cell structure is large, and the diversity of hair cell applications in sensory systems exceeds that seen for most, if not all, sensory cell types. The intent of this review is to summarize the more significant structural features and some of the more interesting and important physiological mechanisms that have been elucidated thus far. Outside vertebrates, hair cells are only known to exist in the coronal organ of tunicates. Electrical resonance, electromotility, and their exquisite mechanical sensitivity all contribute to the attractiveness of hair cells as a research subject.

Bentonite-amended soil special study

International Nuclear Information System (INIS)

1989-12-01

This special study was conducted to assess the viability of soil with a high percentage of bentonite added as an infiltration barrier in the cover of Uranium Mill Tailings Remedial Action (UMTRA) Project disposal cells. To achieve maximum concentration limits (MCLs) at several UMTRA Project sites, covers with a very low permeability are needed. If alternate concentration limits (ACLs) are the appropriate site groundwater compliance strategy, the US Department of Energy (DOE) is required to demonstrate, among other things, that the infiltration to the disposal cell is as low as reasonably achievable, and hence that the cover has a very low permeability. When the study discussed here was begun, the lowest permeability element available was CLAYMAX R , a manufactured liner material constructed of natural material (bentonite clay) between two geosynthetics.The strength of soil-bentonite mixes was measured to see if they could be placed on sideslopes and not pose stability problems. Also evaluated were the hydraulic conductivities of soil-bentonite mixes. If the strengths and permeabilities of soils with a high percentage of bentonite are favorable, the soils may be used as infiltration barriers in current cover designs without changing pile geometries. The scope of work for this study called for a literature review and a two-phased laboratory testing program. This report presents the results of the literature review and the first phase of the testing program

Cultivating a Community of Effective Special Education Teachers: Local Special Education Administrators' Roles

Science.gov (United States)

Bettini, Elizabeth; Benedict, Amber; Thomas, Rachel; Kimerling, Jenna; Choi, Nari; McLeskey, James

2017-01-01

Evidence of the powerful impact teachers have on student achievement has led to an intensive focus on cultivating effective teachers, including special education teachers (SETs). Local special education administrators (LSEAs) share responsibility for cultivating effective SETs throughout their districts. However, the roles LSEAs play in this…

Potential development in dye-sensitized solar cells for renewable energy

CERN Document Server

Pandikumar, Alagarsamy

2013-01-01

The development of photovoltaic technology is expected to solve problems related to energy shortages and environmental pollution caused by the use of fossil fuels. Dye-sensitizedsolar cells (DSSCs) are promising next-generation alternatives to conventional silicon-based photovoltaic devices owing to their low manufacturing cost and potentially high conversion efficiency. This special topic volume addresses recent advances in the research on dye-sensitized solar cells. The focus of this special topic volume is on materials development (sensitizers, nanostructured oxide films, and electrolyte),

Development of special libraries in Slovenia

OpenAIRE

Nada Češnovar

2002-01-01

Although Slovenia is a small European country with only 2 million inhabitants, Slovenian librarianship can be compared with any other bigger country. The staffing and information technology in special libraries have been accelerating for the last four decades.Seventeen years have passed since the first meeting of special libraries. When Slovenia attained independence, numerous changes occured in the field of special librarianship.Due to the economic crisis, several special libraries of enterp...

Research Article Special Issue

African Journals Online (AJOL)

pc

2018-03-07

Mar 7, 2018 ... Eurostat and the Ministry of Economic Development. 4. .... regard to the application of special national schemes for small enterprises. ... 2013) mentions a two-year exemption from the tax on joint stock companies and local taxes. ... specialized support programs are developed, such as the introduction of the ...

Special Education in Jordan

Science.gov (United States)

Abu-Hamour, Bashir; Al-Hmouz, Hanan

2014-01-01

The purpose of this article is to provide a brief background about special education system in Jordan and particularly describes the present types of programmes and legislation provided within the country to students with special needs, as well as integration movement. Jordan has historically provided a limited number of educational opportunities…

Penium margaritaceum as a model organism for cell wall analysis of expanding plant cells

DEFF Research Database (Denmark)

Rydahl, Maja Gro; Fangel, Jonatan Ulrik; Mikkelsen, Maria Dalgaard

2015-01-01

organization of the polymeric networks of the cell wall around the protoplast also contributes to the direction of growth, the shape of the cell, and the proper positioning of the cell in a tissue. In essence, plant cell expansion represents the foundation of development. Most studies of plant cell expansion...... have focused primarily upon late divergent multicellular land plants and specialized cell types (e.g., pollen tubes, root hairs). Here, we describe a unicellular green alga, Penium margaritaceum (Penium), which can serve as a valuable model organism for understanding cell expansion and the underlying......The growth of a plant cell encompasses a complex set of subcellular components interacting in a highly coordinated fashion. Ultimately, these activities create specific cell wall structural domains that regulate the prime force of expansion, internally generated turgor pressure. The precise...

The roles of special proresolving mediators in pain relief.

Science.gov (United States)

Zhang, Lan-Yu; Jia, Ming-Rui; Sun, Tao

2018-02-08

The resolution of acute inflammation, once thought to be a passive process, is now recognized as an active one. The productions of endogenous special proresolving mediators (SPMs) are involved in this process. SPMs, including lipoxins, resolvins, protectins, and maresins, are endogenous lipid mediators generated from ω-6 arachidonic acid or ω-3 poly-unsaturated fatty acids during the resolution phase of acute inflammation. They have potent anti-inflammatory and proresolving actions in various inflammatory disorders. Due to the potent proresolving and anti-inflammatory effects, SPMs are also used for pain relief. This review focuses on the mechanisms by which SPMs act on their respective G-protein-coupled receptors in immune cells and nerve cells to normalize pain via regulating inflammatory mediators, transient receptor potential ion channels, and central sensitization. SPMs may offer novel therapeutic approaches for preventing and treating pain conditions associated with inflammation.

Involvement of specialized DNA polymerases Pol II, Pol IV and DnaE2 in DNA replication in the absence of Pol I in Pseudomonas putida

International Nuclear Information System (INIS)

Sidorenko, Julia; Jatsenko, Tatjana; Saumaa, Signe; Teras, Riho; Tark-Dame, Mariliis; Horak, Rita; Kivisaar, Maia

2011-01-01

The majority of bacteria possess a different set of specialized DNA polymerases than those identified in the most common model organism Escherichia coli. Here, we have studied the ability of specialized DNA polymerases to substitute Pol I in DNA replication in Pseudomonas putida. Our results revealed that P. putida Pol I-deficient cells have severe growth defects in LB medium, which is accompanied by filamentous cell morphology. However, growth of Pol I-deficient bacteria on solid rich medium can be restored by reduction of reactive oxygen species in cells. Also, mutants with improved growth emerge rapidly. Similarly to the initial Pol I-deficient P. putida, its adapted derivatives express a moderate mutator phenotype, which indicates that DNA replication carried out in the absence of Pol I is erroneous both in the original Pol I-deficient bacteria and the adapted derivatives. Analysis of the spectra of spontaneous Rif r mutations in P. putida strains lacking different DNA polymerases revealed that the presence of specialized DNA polymerases Pol II and Pol IV influences the frequency of certain base substitutions in Pol I-proficient and Pol I-deficient backgrounds in opposite ways. Involvement of another specialized DNA polymerase DnaE2 in DNA replication in Pol I-deficient bacteria is stimulated by UV irradiation of bacteria, implying that DnaE2-provided translesion synthesis partially substitutes the absence of Pol I in cells containing heavily damaged DNA.

Natural Killer T Cells in Cancer Immunotherapy

Science.gov (United States)

Nair, Shiny; Dhodapkar, Madhav V.

2017-01-01

Natural killer T (NKT) cells are specialized CD1d-restricted T cells that recognize lipid antigens. Following stimulation, NKT cells lead to downstream activation of both innate and adaptive immune cells in the tumor microenvironment. This has impelled the development of NKT cell-targeted immunotherapies for treating cancer. In this review, we provide a brief overview of the stimulatory and regulatory functions of NKT cells in tumor immunity as well as highlight preclinical and clinical studies based on NKT cells. Finally, we discuss future perspectives to better harness the potential of NKT cells for cancer therapy. PMID:29018445

New frontiers in single-cell analysis

OpenAIRE

Templer, Richard H.; Ces, Oscar

2008-01-01

For this special issue of J. R. Soc. Interface we present an overview of the driving forces behind technological advances in the field of single-cell analysis. These range from increasing our understanding of cellular heterogeneity through to the study of rare cells, areas of research that cannot be tackled effectively using current high-throughput population-based averaging techniques.

40 CFR 1508.26 - Special expertise.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Special expertise. 1508.26 Section 1508.26 Protection of Environment COUNCIL ON ENVIRONMENTAL QUALITY TERMINOLOGY AND INDEX § 1508.26 Special expertise. Special expertise means statutory responsibility, agency mission, or related program...

46 CFR 114.550 - Special consideration.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Special consideration. 114.550 Section 114.550 Shipping... consideration. In applying the provisions of this subchapter, the OCMI may give special consideration to... vessel operates must approve any special consideration granted to the vessel. ...

Reading Intervention and Special Education Referrals

Science.gov (United States)

Polcyn, Dawn M.; Levine-Donnerstein, Deborah; Perfect, Michelle M.; Obrzut, John E.

2014-01-01

This study examined whether consistently implementing reading fluency interventions prior to referring students for a special education evaluation led to fewer overall special education referrals, as well as more accurate special education referrals. Results indicated that the implementation of a peer-mediated reading fluency intervention…

Aging, metabolism and stem cells: Spotlight on muscle stem cells.

Science.gov (United States)

García-Prat, Laura; Muñoz-Cánoves, Pura

2017-04-15

All tissues and organs undergo a progressive regenerative decline as they age. This decline has been mainly attributed to loss of stem cell number and/or function, and both stem cell-intrinsic changes and alterations in local niches and/or systemic environment over time are known to contribute to the stem cell aging phenotype. Advancing in the molecular understanding of the deterioration of stem cell cells with aging is key for targeting the specific causes of tissue regenerative dysfunction at advanced stages of life. Here, we revise exciting recent findings on why stem cells age and the consequences on tissue regeneration, with a special focus on regeneration of skeletal muscle. We also highlight newly identified common molecular pathways affecting diverse types of aging stem cells, such as altered proteostasis, metabolism, or senescence entry, and discuss the questions raised by these findings. Finally, we comment on emerging stem cell rejuvenation strategies, principally emanating from studies on muscle stem cells, which will surely burst tissue regeneration research for future benefit of the increasing human aging population. Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

46 CFR 175.550 - Special consideration.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 175.550 Section 175.550 Shipping...) GENERAL PROVISIONS § 175.550 Special consideration. In applying the provisions of this subchapter, the OCMI may give special consideration to authorizing departures from the specific requirements when...

A protocol to assess cell cycle and apoptosis in human and mouse pluripotent cells

Directory of Open Access Journals (Sweden)

Edel Michael J

2011-04-01

Full Text Available Abstract Embryonic stem cells (ESC and induced pluripotent stem cells (iPSCs present a great opportunity to treat and model human disease as a cell replacement therapy. There is a growing pressure to understand better the signal transduction pathways regulating pluripotency and self-renewal of these special cells in order to deliver a safe and reliable cell based therapy in the near future. Many signal transduction pathways converge on two major cell functions associated with self-renewal and pluripotency: control of the cell cycle and apoptosis, although a standard method is lacking across the field. Here we present a detailed protocol to assess the cell cycle and apoptosis of ESC and iPSCs as a single reference point offering an easy to use standard approach across the field.

15 CFR 2301.5 - Special consideration.

Science.gov (United States)

2010-01-01

... 15 Commerce and Foreign Trade 3 2010-01-01 2010-01-01 false Special consideration. 2301.5 Section... PROGRAM Application Requirements § 2301.5 Special consideration. In accordance with section 392(f) of the Act, the Agency will give special consideration to applications that foster ownership of, operation of...

46 CFR 169.112 - Special consideration.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 169.112 Section 169.112 Shipping... Provisions § 169.112 Special consideration. In applying the provisions of this part, the Officer in Charge, Marine Inspection, may give special consideration to departures from the specific requirements when...

7 CFR 632.18 - Special projects.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Special projects. 632.18 Section 632.18 Agriculture... AGRICULTURE LONG TERM CONTRACTING RURAL ABANDONED MINE PROGRAM Qualifications § 632.18 Special projects. (a) The NRCS State conservationist may approve the following types of special projects subject to the...

38 CFR 3.801 - Special acts.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Special acts. 3.801 Section 3.801 Pensions, Bonuses, and Veterans' Relief DEPARTMENT OF VETERANS AFFAIRS ADJUDICATION Pension, Compensation, and Dependency and Indemnity Compensation Special Benefits § 3.801 Special acts. (a) General. A...

Coexistence of Quiescent and Active Adult Stem Cells in Mammals

NARCIS (Netherlands)

Li, Linheng; Clevers, Hans

2010-01-01

Adult stem cells are crucial for physiological tissue renewal and regeneration after injury. Prevailing models assume the existence of a single quiescent population of stem cells residing in a specialized niche of a given tissue. Emerging evidence indicates that both quiescent (out of cell cycle and

27 CFR 44.145 - Special.

Science.gov (United States)

2010-04-01

... PAYMENT OF TAX, OR WITH DRAWBACK OF TAX Operations by Export Warehouse Proprietors Inventories § 44.145 Special. A special inventory shall be made by the export warehouse proprietor whenever required by any...

75 FR 50850 - Special Conditions: AeroMech, Incorporated; Hawker Beechcraft Corporation, Model B200 and Other...

Science.gov (United States)

2010-08-18

... heat the battery can generate during a short circuit of the battery or of its individual cells. (7) Li... inspection requirements to visually check for a battery and/or charger degradation. (vi) The ICA must contain... Lithium Ion Battery AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final special conditions...

The cell cycle of the planctomycete Gemmata obscuriglobus with respect to cell compartmentalization

Directory of Open Access Journals (Sweden)

Fuerst John A

2009-01-01

Full Text Available Abstract Background Gemmata obscuriglobus is a distinctive member of the divergent phylum Planctomycetes, all known members of which are peptidoglycan-less bacteria with a shared compartmentalized cell structure and divide by a budding process. G. obscuriglobus in addition shares the unique feature that its nucleoid DNA is surrounded by an envelope consisting of two membranes forming an analogous structure to the membrane-bounded nucleoid of eukaryotes and therefore G. obscuriglobus forms a special model for cell biology. Draft genome data for G. obscuriglobus as well as complete genome sequences available so far for other planctomycetes indicate that the key bacterial cell division protein FtsZ is not present in these planctomycetes, so the cell division process in planctomycetes is of special comparative interest. The membrane-bounded nature of the nucleoid in G. obscuriglobus also suggests that special mechanisms for the distribution of this nuclear body to the bud and for distribution of chromosomal DNA might exist during division. It was therefore of interest to examine the cell division cycle in G. obscuriglobus and the process of nucleoid distribution and nuclear body formation during division in this planctomycete bacterium via light and electron microscopy. Results Using phase contrast and fluorescence light microscopy, and transmission electron microscopy, the cell division cycle of G. obscuriglobus was determined. During the budding process, the bud was formed and developed in size from one point of the mother cell perimeter until separation. The matured daughter cell acted as a new mother cell and started its own budding cycle while the mother cell can itself initiate budding repeatedly. Fluorescence microscopy of DAPI-stained cells of G. obscuriglobus suggested that translocation of the nucleoid and formation of the bud did not occur at the same time. Confocal laser scanning light microscopy applied to cells stained for membranes as

5 CFR 9701.361 - Special skills payments.

Science.gov (United States)

2010-01-01

... RESOURCES MANAGEMENT SYSTEM Pay and Pay Administration Special Payments § 9701.361 Special skills payments... at the same time as basic pay or in periodic lump-sum payments. Special skills payments are not basic... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Special skills payments. 9701.361 Section...

Promoting Special Educator Teacher Retention

Directory of Open Access Journals (Sweden)

Jeremy E. Vittek

2015-06-01

Full Text Available This article is a critical review of the literature on special education teacher attrition and retention. The research focused on journal articles from 2004 to present. The results of the study helped define special educator attrition and retention. The major themes present in the findings were job satisfaction, administrative support, induction programs, and mentoring. The literature shows a clear need for comprehensive administrative support to improve job satisfaction and the likelihood a special educator will remain in their job.

Special education and later academic achievement.

Science.gov (United States)

Ehrhardt, Jennifer; Huntington, Noelle; Molino, Janine; Barbaresi, William

2013-02-01

To determine whether grade at entry to special education is associated with improved reading achievement in children with reading disorders (RD) and whether the effect of grade at entry to special education differs by socioeconomic status (SES). The authors conducted a secondary data analysis using data from the Early Childhood Longitudinal Study-Kindergarten Cohort (ECLS-K), a nationally representative cohort of children followed longitudinally from kindergarten through eighth grade (1998-2007). Using data from the fifth grade wave of ECLS-K, the authors identified children with RD (n = 290). The outcome of interest was change in score on the reading achievement test, which was developed by ECLS-K staff, between first and fifth grade. Using multiple linear regression, the authors modeled outcome as a function of a child's grade at entry to special education, controlling for several covariates. Early entry to special education (by first grade vs second or third grade) was associated with larger gains in reading achievement between first and fifth grade (p special education by first grade versus second grade gained 4.5 more points on the reading achievement test (p special education by first grade versus third grade gained 1.7 more points on the reading achievement test (p special education between children from families of low and higher SES. For children with RD, early entry to special education is associated with improved reading achievement during elementary school.

Towards unifying inheritance and automatic program specialization

DEFF Research Database (Denmark)

Schultz, Ulrik Pagh

2002-01-01

and specialization of classes (inheritance) are considered different abstractions. We present a new programming language, Lapis, that unifies inheritance and program specialization at the conceptual, syntactic, and semantic levels. This paper presents the initial development of Lapis, which uses inheritance...... with covariant specialization to control the automatic application of program specialization to class members. Lapis integrates object-oriented concepts, block structure, and techniques from automatic program specialization to provide both a language where object-oriented designs can be e#ciently implemented...

Special quasirandom structures for gadolinia-doped ceria and related materials

KAUST Repository

Wang, Hao

2012-01-01

Gadolinia doped ceria in its doped or strained form is considered to be an electrolyte for solid oxide fuel cell applications. The simulation of the defect processes in these materials is complicated by the random distribution of the constituent atoms. We propose the use of the special quasirandom structure (SQS) approach as a computationally efficient way to describe the random nature of the local cation environment and the distribution of the oxygen vacancies. We have generated two 96-atom SQS cells describing 9% and 12% gadolinia doped ceria. These SQS cells are transferable and can be used to model related materials such as yttria stabilized zirconia. To demonstrate the applicability of the method we use density functional theory to investigate the influence of the local environment around a Y dopant in Y-codoped gadolinia doped ceria. It is energetically favourable if Y is not close to Gd or an oxygen vacancy. Moreover, Y-O bonds are found to be weaker than Gd-O bonds so that the conductivity of O ions is improved. © 2012 the Owner Societies.

Penium margaritaceum as a model organism for cell wall analysis of expanding plant cells.

Science.gov (United States)

Rydahl, Maja G; Fangel, Jonatan U; Mikkelsen, Maria Dalgaard; Johansen, I Elisabeth; Andreas, Amanda; Harholt, Jesper; Ulvskov, Peter; Jørgensen, Bodil; Domozych, David S; Willats, William G T

2015-01-01

The growth of a plant cell encompasses a complex set of subcellular components interacting in a highly coordinated fashion. Ultimately, these activities create specific cell wall structural domains that regulate the prime force of expansion, internally generated turgor pressure. The precise organization of the polymeric networks of the cell wall around the protoplast also contributes to the direction of growth, the shape of the cell, and the proper positioning of the cell in a tissue. In essence, plant cell expansion represents the foundation of development. Most studies of plant cell expansion have focused primarily upon late divergent multicellular land plants and specialized cell types (e.g., pollen tubes, root hairs). Here, we describe a unicellular green alga, Penium margaritaceum (Penium), which can serve as a valuable model organism for understanding cell expansion and the underlying mechanics of the cell wall in a single plant cell.

7 CFR 29.2299 - Special factor.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Special factor. 29.2299 Section 29.2299 Agriculture... Special factor. A symbol or term authorized to be used with specified grades. Tobacco to which a special factor is applied may meet the general specifications but has a peculiar side or characteristic which...

7 CFR 29.3057 - Special factor.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Special factor. 29.3057 Section 29.3057 Agriculture... Special factor. A symbol or term authorized to be used with specified grades. Tobacco to which a special factor is applied may meet the general specifications but has a peculiar side or characteristic which...

Propagation of bovine spermatogonial stem cells in vitro

NARCIS (Netherlands)

Aponte, Pedro M.; Soda, Takeshi; Teerds, Katja J.; Mizrak, S. Canan; van de Kant, Henk J. G.; de Rooij, Dirk G.

2008-01-01

The access to sufficient numbers of spermatogonial stem cells (SSCs) is a prerequisite for the study of their regulation and further biomanipulation. A specialized medium and several growth factors were tested to study the in vitro behavior of bovine type A spermatogonia, a cell population that

Update on small intestinal stem cells

OpenAIRE

Tesori, Valentina; Puglisi, Maria Ausiliatrice; Lattanzi, Wanda; Gasbarrini, Giovanni Battista; Gasbarrini, Antonio

2013-01-01

Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to id...

Dendritic cells in oral tolerance in the gut.

Science.gov (United States)

Rescigno, Maria

2011-09-01

Oral tolerance is a process that allows generation of systemic unresponsiveness to food antigens. Hence if the same antigen is introduced systemically even under immunogenic conditions it does not induce immune responsiveness. Dendritic cells (DCs) have been identified as essential players in this process. DCs in the gut are located in a strategic position as they can interact directly with luminal antigens or indirectly after their transcytosis across epithelial cells. DCs can then migrate to associated lymphoid tissues to induce tolerance. Antigen presenting cells in the gut are specialized in function and have divided their labour so that there are cells capable to migrate to the draining mesenteric lymph node for induction of T regulatory cells, while other subsets are resident and are required to enforce tolerance locally in the gut after food antigen exposure. In this review, I shall summarize the characteristics of antigen presenting cells in the gut and their involvement in oral tolerance induction. In addition, I will also emphasize that tolerance to food allergens may be contributed by plasmacytoid DCs in the liver that participate to the elimination or anergy of allergen-specific CD8 T cells. Hence specialized functions are associated to different subsets of antigen presenting cells and different organs. © 2011 Blackwell Publishing Ltd.

Root canal treatment and special needs patients.

Science.gov (United States)

Yap, E; Parashos, P; Borromeo, G L

2015-04-01

To identify current trends of root canal treatment for patients with special needs. A postal questionnaire was sent to General Dentists in Victoria, Australia and Endodontists and Special Needs Dentists across Australia to determine the extent of root canal treatment performed on special needs patients. Over a four-month period, 1120 questionnaires were distributed with an overall response rate of 63.9% (n = 716). Response rates were 63.2% (n = 655), 68.5% (n = 50) and 100.0% (n = 11) amongst General Dentists, Endodontists and Special Needs Dentists, respectively. Endodontists (95.7%) and Special Needs Dentists (100.0%) performed significantly more root canal treatment on adult patients with special needs compared with 51.2% of General Dentists, (P special needs patients compared with only 29.7% of General Dentists (P special needs patients was more likely to be carried out by specialist dental practitioners who were more likely to utilize a pharmacological approach for behaviour guidance and to perform single-visit root canal treatment compared with General Dentists. A multidisciplinary approach for special needs patients who require root canal treatment provides an opportunity for these patients to retain their dentition. © 2014 International Endodontic Journal. Published by John Wiley & Sons Ltd.

The hair follicle bulge: a niche for adult stem cells.

Science.gov (United States)

Pasolli, Hilda Amalia

2011-08-01

Adult stem cells (SCs) are essential for tissue homeostasis and wound repair. They have the ability to both self-renew and differentiate into multiple cell types. They often reside in specialized microenvironments or niches that preserve their proliferative and tissue regenerative capacity. The murine hair follicle (HF) has a specialized and permanent compartment--the bulge, which safely lodges SCs and provides the necessary molecular cues to regulate their function. The HF undergoes cyclic periods of destruction, regeneration, and rest, making it an excellent system to study SC biology.

Special Education and General Education--Coordinated or Separated? A Study of Curriculum Planning for Pupils with Special Educational Needs

Science.gov (United States)

Nilsen, Sven

2017-01-01

The central issue of this article is the coordination between special and general education in curriculum planning for pupils with special educational needs. The focus is on individual education plans (IEPs) in special education and work plans in general education. This is also viewed in relation to how special and general education teachers…

7 CFR 29.1059 - Special factor.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Special factor. 29.1059 Section 29.1059 Agriculture... Type 92) § 29.1059 Special factor. A symbol or term authorized to be used with specified grades. Tobacco to which a special factor is applied may meet the general specifications but which has a peculiar...

International Specialization

DEFF Research Database (Denmark)

Kleindienst, Ingo; Geisler Asmussen, Christian; Hutzschenreuter, Thomas

2012-01-01

Whether and how international diversification and cross-border arbitrage affects firm performance remains one of the major unresolved research questions in the strategy and international business literatures. We propose that knowing how much a firm has internationally diversified tells us very...... little about performance implications, if we do not know, and do not ask, how the firm has diversified. Therefore, building on the two broad arguments of operating flexibility and location-specific commitment, we develop a theoretical framework that focuses on the extent to which a firm's international...... arbitrage strategy is characterized by specialization versus replication and argue that these different strategies may have differential impact on profitability and risk reduction. Developing a sophisticated measure of international specialization and using a unique panel data set of 92 German MNEs to test...

Stem cells and the evolving notion of cellular identity

OpenAIRE

Daley, George Q.

2015-01-01

Stem cells are but one class of the myriad types of cells within an organism. With potential to self-renew and capacity to differentiate, stem cells play essential roles at multiple stages of development. In the early embryo, pluripotent stem cells represent progenitors for all tissues while later in development, tissue-restricted stem cells give rise to cells with highly specialized functions. As best understood in the blood, skin and gut, stem cells are the seeds that sustain tissue homeost...

Photoenzyme probes of photodamage to cells and cellular DNA

Energy Technology Data Exchange (ETDEWEB)

Sutherland, B. M.

1979-01-01

Development of photoenzyme probes for detection of ultraviolet damage to cells and DNA is reviewed with special emphasis on a process using polyethylene glycol to induce cell fusion. Polyethylene glycol is easy to obtain and handle, is gentle to the cells and does not induce latent or productive virus infection; therefore, it may be a general method for insertion of exogenous enzymes into mammalian cells. (PCS)

Special Education Reform Towards Inclusive Education: Blurring or Expanding Boundaries of Special and Regular Education in China

Science.gov (United States)

Deng, Meng; Zhu, Xinhua

2016-01-01

China has developed a three-tier special education service delivery system consisting of an array of placement options of special schools, special classes and learning in regular classrooms (LRC) (with the LRC as the major initiative) to serve students with disabilities after 1980s responding to the international trend of inclusive education…

7 CFR 29.2551 - Special factor.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Special factor. 29.2551 Section 29.2551 Agriculture...-Cured Tobacco (u.s. Types 22, 23, and Foreign Type 96) § 29.2551 Special factor. A symbol or term authorized to be used with specified grades. Tobacco to which a special factor is applied may meet the...

Phenothiazine-Based Dyes in Solar Cell Technology

Directory of Open Access Journals (Sweden)

Andrei Bejan

2017-12-01

Full Text Available Phenothiazine is a fused heterocyclic ring with strong electron-donating character which makes it an important building block for designing organic materials for solar cells applications. The present paper reviews the most recent achievements of phenothiazine-based compounds as dyes in solar cells, with special emphasis on the structure – performance relationship.

Spatial geometry and special relativity

DEFF Research Database (Denmark)

Kneubil, Fabiana Botelho

2016-01-01

In this work, it is shown the interplay of relative and absolute entities, which are present in both spatial geometry and special relativity. In order to strengthen the understanding of special relativity, we discuss firstly an instance of geometry and the existence of both frame......-dependent and frame-independent entities. We depart from a subject well known by students, which is the three-dimensional geometric space in order to compare, afterwards, with the treatment of four-dimensional space in the special relativity. The differences and similarities between these two subjects are also...

Special relativity a first encounter

CERN Document Server

Giulini, Domenico

2005-01-01

Special relativity provides the foundations of our knowledge of space and time. Without it, our understanding of the world, and its place in the universe, would be unthinkable. This book gives a concise, elementary, yet exceptionally modern, introduction to special relativity. It is a gentle yet serious 'first encounter', in that it conveys a true understanding rather than purely reports the basic facts. Only very elementary mathematical knowledge is needed to master it (basichigh-school maths), yet it will leave the reader with a sound understanding of the subject. Special Relativity: A First

Stem cells from residual IVF-embryos - Continuation of life justifies isolation.

NARCIS (Netherlands)

Bongaerts, G.P.A.; Severijnen, R.S.V.M.

2007-01-01

Embryonic stem cells are undifferentiated pluripotent cells that can indefinitely grow in vitro. They are derived from the inner mass of early embryos. Because of their ability to differentiate into all three embryonic germ layers, and finally into specialized somatic cell types, human embryonic

The Special Court for Sierra Leone

DEFF Research Database (Denmark)

Damgaard, Ciara Therése

2004-01-01

The focus of this article is the Special Court for Sierra Leone and the extent to which it can be said that the Special Court has already challenged, or will, in the future, challenge the tradition of impunity for gender-based crimes. In this regard, an analysis is undertaken of the Special Court......'s Statute, Rules of Procedure and Evidence and practice to date, in order to determine its treatment of gender-based crimes and whether it can be said that the Special Court for Sierra Leone challenges the tradition of impunity for gender-based crimes. Udgivelsesdato: december 2004...

Giant cells around bone biomaterials: Osteoclasts or multi-nucleated giant cells?

Science.gov (United States)

Miron, Richard J; Zohdi, Hamoon; Fujioka-Kobayashi, Masako; Bosshardt, Dieter D

2016-12-01

Recently accumulating evidence has put into question the role of large multinucleated giant cells (MNGCs) around bone biomaterials. While cells derived from the monocyte/macrophage lineage are one of the first cell types in contact with implanted biomaterials, it was originally thought that specifically in bone tissues, all giant cells were bone-resorbing osteoclasts whereas foreign body giant cells (FBGCs) were found associated with a connective tissue foreign body reaction resulting in fibrous encapsulation and/or material rejection. Despite the great majority of bone grafting materials routinely found with large osteoclasts, a special subclass of bone biomaterials has more recently been found surrounded by large giant cells virtually incapable of resorbing bone grafts even years after their implantation. While original hypotheses believed that a 'foreign body reaction' may be taking place, histological data retrieved from human samples years after their implantation have put these original hypotheses into question by demonstrating better and more stable long-term bone volume around certain bone grafts. Exactly how or why this 'special' subclass of giant cells is capable of maintaining long-term bone volume, or methods to scientifically distinguish them from osteoclasts remains extremely poorly studied. The aim of this review article was to gather the current available literature on giant cell markers and differences in expression patterns between osteoclasts and MNGCs utilizing 19 specific markers including an array of CD-cell surface markers. Furthermore, the concept of now distinguishing between pro-inflammatory M1-MNGCs (previously referred to as FBGCs) as well as wound-healing M2-MNGCs is introduced and discussed. This review article presents 19 specific cell-surface markers to distinguish between osteoclasts and MNGCs including an array of CD-cell surface markers. Furthermore, the concept of now distinguishing between pro-inflammatory M1-MNGCs (often

A Simple Solution to Type Specialization

DEFF Research Database (Denmark)

Danvy, Olivier

1998-01-01

Partial evaluation specializes terms, but traditionally this specialization does not apply to the type of these terms. As a result, specializing, e.g., an interpreter written in a typed language, which requires a “universal” type to encode expressible values, yields residual programs with type tags...... all over. Neil Jones has stated that getting rid of these type tags was an open problem, despite possible solutions such as Torben Mogensen's “constructor specialization.” To solve this problem, John Hughes has proposed a new paradigm for partial evaluation, “Type Specialization”, based on type...... inference instead of being based on symbolic interpretation. Type Specialization is very elegant in principle but it also appears non-trivial in practice. Stating the problem in terms of types instead of in terms of type encodings suggests a very simple type-directed solution, namely, to use a projection...

SPACES OF WELLBEING : WHAT IS SO SPECIAL ABOUT SPECIAL NEEDS ART STUDIOS?

OpenAIRE

Radcliffe, David

2013-01-01

ABSTRACT Radcliffe, David. Spaces of Wellbeing, What is so special about special needs art studios? Autumn 2013, 73 p., 2 appendices. Diaconia University of Applied Sciences, Degree Programme in Social Services + option in Diaconal Social Work, Bachelor of Social Services (UAS) + Qualifi-cation for the office of diaconia worker in The Church of Finland. The aim of this thesis is to discover the common experiences of art studio par-ticipants in relation to wellbeing. This has become a...

Regional specialization within the intestinal immune system

DEFF Research Database (Denmark)

Mowat, Allan M.; Agace, William Winston

2014-01-01

The intestine represents the largest compartment of the immune system. It is continually exposed to antigens and immunomodulatory agents from the diet and the commensal microbiota, and it is the port of entry for many clinically important pathogens. Intestinal immune processes are also increasingly...... implicated in controlling disease development elsewhere in the body. In this Review, we detail the anatomical and physiological distinctions that are observed in the small and large intestines, and we suggest how these may account for the diversity in the immune apparatus that is seen throughout...... the intestine. We describe how the distribution of innate, adaptive and innate-like immune cells varies in different segments of the intestine and discuss the environmental factors that may influence this. Finally, we consider the implications of regional immune specialization for inflammatory disease...

'Special K' and a Loss of Cell-To-Cell Adhesion in Proximal Tubule-Derived Epithelial Cells: Modulation of the Adherens Junction Complex by Ketamine

Science.gov (United States)

Hills, Claire E.; Jin, Tianrong; Siamantouras, Eleftherios; Liu, Issac K-K; Jefferson, Kieran P.; Squires, Paul E.

2013-01-01

Ketamine, a mild hallucinogenic class C drug, is the fastest growing ‘party drug’ used by 16–24 year olds in the UK. As the recreational use of Ketamine increases we are beginning to see the signs of major renal and bladder complications. To date however, we know nothing of a role for Ketamine in modulating both structure and function of the human renal proximal tubule. In the current study we have used an established model cell line for human epithelial cells of the proximal tubule (HK2) to demonstrate that Ketamine evokes early changes in expression of proteins central to the adherens junction complex. Furthermore we use AFM single-cell force spectroscopy to assess if these changes functionally uncouple cells of the proximal tubule ahead of any overt loss in epithelial cell function. Our data suggests that Ketamine (24–48 hrs) produces gross changes in cell morphology and cytoskeletal architecture towards a fibrotic phenotype. These physical changes matched the concentration-dependent (0.1–1 mg/mL) cytotoxic effect of Ketamine and reflect a loss in expression of the key adherens junction proteins epithelial (E)- and neural (N)-cadherin and β-catenin. Down-regulation of protein expression does not involve the pro-fibrotic cytokine TGFβ, nor is it regulated by the usual increase in expression of Slug or Snail, the transcriptional regulators for E-cadherin. However, the loss in E-cadherin can be partially rescued pharmacologically by blocking p38 MAPK using SB203580. These data provide compelling evidence that Ketamine alters epithelial cell-to-cell adhesion and cell-coupling in the proximal kidney via a non-classical pro-fibrotic mechanism and the data provides the first indication that this illicit substance can have major implications on renal function. Understanding Ketamine-induced renal pathology may identify targets for future therapeutic intervention. PMID:24009666

The regulation of growth and metabolism of kidney stem cell with regional specificity using extracellular matrix derived from kidney

OpenAIRE

O’Neill, John D.; Freytes, Donald O.; Anandappa, Annabelle; Oliver, Juan A.; Vunjak-Novakovic, Gordana

2013-01-01

Native extracellular matrix (ECM) that is secreted and maintained by resident cells is of great interest for cell culture and cell delivery. We hypothesized that specialized bioengineered niches for stem cells can be established using ECM-derived scaffolding materials. Kidney was selected as a model system because of the high regional diversification of renal tissue matrix. By preparing the ECM from three specialized regions of the kidney (cortex, medulla, and papilla; whole kidney, heart, an...

TOPOGRAPHIC ORGANIZATION AND SPECIALIZED AREAS IN THE RETINA OF Callopistes palluma: GANGLION CELL LAYER

OpenAIRE

Inzunza, Oscar; Barros B., Zitta; Bravo, Hermes

1998-01-01

In this paper we analyze the topographic distribution and cell body size of neurons (ganglion and displaced amacrine) of layer 8 of the retina in the chilean reptile Callopistes palluma; using whole mount retinaswith nissl stain. Callopistes palluma retina has an area centralis without fovea in which the ganglion cell density amounts 20.000 cells / µm2 while the displaced amacrine neurons is about 7.000 cells / µm2. This neural density decreased gradually towards the peripheral retina. A hor...

Structural analysis of cell wall polysaccharides using PACE

Energy Technology Data Exchange (ETDEWEB)

Mortimer, Jennifer C. [Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States). Joint BioEnergy Institute

2017-01-01

The plant cell wall is composed of many complex polysaccharides. The composition and structure of the polysaccharides affect various cell properties including cell shape, cell function and cell adhesion. Many techniques to characterize polysaccharide structure are complicated, requiring expensive equipment and specialized operators e.g. NMR, MALDI-MS. PACE (Polysaccharide Analysis using Carbohydrate gel Electrophoresis) uses a simple, rapid technique to analyze polysaccharide quantity and structure (Goubet et al. 2002). Whilst the method here describes xylan analysis, it can be applied (by use of the appropriate glycosyl hydrolase) to any cell wall polysaccharide.

From embryonic stem cells to functioning germ cells: science, clinical and ethical perspectives.

Science.gov (United States)

Kiatpongsan, Sorapop

2007-10-01

Embryonic stem cells have been well recognized as cells having a versatile potential to differentiate into all types of cells in the body including germ cells. There are many research studies focusing on the differentiation processes and protocols to derive various types of somatic cells from embryonic stem cells. However, germ cells have unique differentiation process and developmental pathway compared with somatic cells. Consequently, they will require different differentiation protocols and special culture techniques. More understanding and established in vitro systems for gametogenesis will greatly contribute to further progression of knowledge and technology in germ cell biology, reproductive biology and reproductive medicine. Moreover if oocytes can be efficiently produced in vitro, this will play an important role on progression in nuclear transfer and nuclear reprogramming technology. The present article will provide concise review on past important discoveries, current ongoing studies and future views of this challenging research area. An ethical perspective has also been proposed to give comprehensive summary and viewpoint for future clinical application.

In vivo differentiation of induced pluripotent stem cells into neural stem cells by chimera formation.

Science.gov (United States)

Choi, Hyun Woo; Hong, Yean Ju; Kim, Jong Soo; Song, Hyuk; Cho, Ssang Gu; Bae, Hojae; Kim, Changsung; Byun, Sung June; Do, Jeong Tae

2017-01-01

Like embryonic stem cells, induced pluripotent stem cells (iPSCs) can differentiate into all three germ layers in an in vitro system. Here, we developed a new technology for obtaining neural stem cells (NSCs) from iPSCs through chimera formation, in an in vivo environment. iPSCs contributed to the neural lineage in the chimera, which could be efficiently purified and directly cultured as NSCs in vitro. The iPSC-derived, in vivo-differentiated NSCs expressed NSC markers, and their gene-expression pattern more closely resembled that of fetal brain-derived NSCs than in vitro-differentiated NSCs. This system could be applied for differentiating pluripotent stem cells into specialized cell types whose differentiation protocols are not well established.

The potential application of stem cell in dentistry

Directory of Open Access Journals (Sweden)

Ketut Suardita

2006-12-01

Full Text Available Stem cells are generally defined as cells that have the capacity to self-renewal and differentiate to specialize cell. There are two kinds of stem cell, embryonic stem cell and adult stem cells. Stem cell therapy has been used to treat diseases including Parkinson’s and Alzheimer’s diseases, spinal cord injury, stroke, burns, heart diseases, diabetes, osteoarthritis, and rheumatoid arthritis. Stem cells were found in dental pulp, periodontal ligament, and alveolar bone marrow. Because of their potential in medical therapy, stem cells were used to regenerate lost or damage teeth and periodontal structures. This article discusses the potential application of stem cells for dental field.

The Business of Running a Special Library

Science.gov (United States)

Waldron, Helen J.

1971-01-01

This paper, a lecture to library school students, presents in detail four elements that make a special library special," as background for a discussion of suggested approaches to follow in managing a special library. (Author/AB)

Habitat specialization through germination cueing

DEFF Research Database (Denmark)

Ten Brink, Dirk-Jan; Hendriksma, Harmen; Bruun, Hans Henrik

2013-01-01

This study examined the adaptive association between seed germination ecology and specialization to either forest or open habitats across a range of evolutionary lineages of seed plants, in order to test the hypotheses that (1) species' specialization to open vs. shaded habitats is consistently...

Regulation of Pituitary Stem Cells by Epithelial to Mesenchymal Transition Events and Signaling Pathways

Science.gov (United States)

Cheung, Leonard Y. M.; Davis, Shannon W.; Brinkmeier, Michelle L.; Camper, Sally A.; Pérez-Millán, María Inés

2017-01-01

The anterior pituitary gland is comprised of specialized cell-types that produce and secrete polypeptide hormones in response to hypothalamic input and feedback from target organs. These specialized cells arise from stem cells that express SOX2 and the pituitary transcription factor PROP1, which is necessary to establish the stem cell pool and promote an epithelial to mesenchymal-like transition, releasing progenitors from the niche. The adult anterior pituitary responds to physiological challenge by mobilizing the SOX2-expressing progenitor pool and producing additional hormone-producing cells. Knowledge of the role of signaling pathways and extracellular matrix components in these processes may lead to improvements in the efficiency of differentiation of embryonic stem cells or induced pluripotent stem cells into hormone producing cells in vitro. Advances in our basic understanding of pituitary stem cell regulation and differentiation may lead to improved diagnosis and treatment for patients with hypopituitarism. PMID:27650955

Streptomyces sporulation - Genes and regulators involved in bacterial cell differentiation

OpenAIRE

Larsson, Jessica

2010-01-01

Streptomycetes are Gram-positive bacteria with a complex developmental life cycle. They form spores on specialized cells called aerial hyphae, and this sporulation involves alterations in growth, morphogenesis and cell cycle processes like cell division and chromosome segregation. Understanding the developmental mechanisms that streptomycetes have evolved for regulating for example cell division is of general interest in bacterial cell biology. It can also be valuable in the design of new dru...

Pre-Clinical Cell-Based Therapy for Limbal Stem Cell Deficiency.

Science.gov (United States)

Sehic, Amer; Utheim, Øygunn Aass; Ommundsen, Kristoffer; Utheim, Tor Paaske

2015-08-28

The cornea is essential for normal vision by maintaining transparency for light transmission. Limbal stem cells, which reside in the corneal periphery, contribute to the homeostasis of the corneal epithelium. Any damage or disease affecting the function of these cells may result in limbal stem cell deficiency (LSCD). The condition may result in both severe pain and blindness. Transplantation of ex vivo cultured cells onto the cornea is most often an effective therapeutic strategy for LSCD. The use of ex vivo cultured limbal epithelial cells (LEC), oral mucosal epithelial cells, and conjunctival epithelial cells to treat LSCD has been explored in humans. The present review focuses on the current state of knowledge of the many other cell-based therapies of LSCD that have so far exclusively been explored in animal models as there is currently no consensus on the best cell type for treating LSCD. Major findings of all these studies with special emphasis on substrates for culture and transplantation are systematically presented and discussed. Among the many potential cell types that still have not been used clinically, we conclude that two easily accessible autologous sources, epidermal stem cells and hair follicle-derived stem cells, are particularly strong candidates for future clinical trials.

Adipose-derived mesenchymal stromal cells for chronic myocardial ischemia (MyStromalCell Trial)

DEFF Research Database (Denmark)

Qayyum, Abbas Ali; Haack-Sørensen, Mandana; Mathiasen, Anders Bruun

2012-01-01

Adipose tissue represents an abundant, accessible source of multipotent adipose-derived stromal cells (ADSCs). Animal studies have suggested that ADSCs have the potential to differentiate in vivo into endothelial cells and cardiomyocytes. This makes ADSCs a promising new cell source...... for regenerative therapy to replace injured tissue by creating new blood vessels and cardiomyocytes in patients with chronic ischemic heart disease. The aim of this special report is to review the present preclinical data leading to clinical stem cell therapy using ADSCs in patients with ischemic heart disease....... In addition, we give an introduction to the first-in-man clinical trial, MyStromalCell Trial, which is a prospective, randomized, double-blind, placebo-controlled study using culture-expanded ADSCs obtained from adipose-derived cells from abdominal adipose tissue and stimulated with VEGF-A(165) the week...

Single cell-type comparative metabolomics of epidermal bladder cells from the halophyte Mesembryanthemum crystallinum

OpenAIRE

Barkla, Bronwyn J.; Vera-Estrella, Rosario

2015-01-01

One of the remarkable adaptive features of the halophyte and facultative CAM plant Mesembryathemum crystallinum are the specialized modified trichomes called epidermal bladder cells (EBC) which cover the leaves, stems, and peduncle of the plant. They are present from an early developmental stage but upon salt stress rapidly expand due to the accumulation of water and sodium. This particular plant feature makes it an attractive system for single cell type studies, with recent proteomics and tr...

Regulatory dendritic cell therapy: from rodents to clinical application

OpenAIRE

Raïch-Regué, Dalia; Glancy, Megan; Thomson, Angus W.

2013-01-01

Dendritic cells (DC) are highly-specialized, bone marrow-derived antigen-presenting cells that induce or regulate innate and adaptive immunity. Regulatory or “tolerogenic” DC play a crucial role in maintaining self tolerance in the healthy steady-state. These regulatory innate immune cells subvert naïve or memory T cell responses by various mechanisms. Regulatory DC (DCreg) also exhibit the ability to induce or restore T cell tolerance in many animal models of autoimmune disease or transplant...

Centroacinar cells: At the center of pancreas regeneration.

Science.gov (United States)

Beer, Rebecca L; Parsons, Michael J; Rovira, Meritxell

2016-05-01

The process of regeneration serves to heal injury by replacing missing cells. Understanding regeneration can help us replace cell populations lost during disease, such as the insulin-producing β cells lost in diabetic patients. Centroacinar cells (CACs) are a specialized ductal pancreatic cell type that act as progenitors to replace β cells in the zebrafish. However, whether CACs contribute to β-cell regeneration in adult mammals remains controversial. Here we review the current understanding of the role of CACs as endocrine progenitors during regeneration in zebrafish and mammals. Copyright © 2016 Elsevier Inc. All rights reserved.

Listing Specialization and Residential Real Estate Licensee

OpenAIRE

Leonard V. Zumpano; Ken Johnson; Randy I. Anderson

2007-01-01

Earlier research has found that specialization by real estate agents creates economies of scope for real estate firms. So far, however, no research has addressed this issue at the agent level. The question this research seeks to answer is whether specialization in one side of the real estate transaction increases agent income. The most important finding is that specialization has an asymmetric impact on earnings. Specializing in listings positively enhances agent income. In contrast, speciali...

Sport Specialization, Part I

OpenAIRE

Myer, Gregory D.; Jayanthi, Neeru; Difiori, John P.; Faigenbaum, Avery D.; Kiefer, Adam W.; Logerstedt, David; Micheli, Lyle J.

2015-01-01

Context: There is increased growth in sports participation across the globe. Sports specialization patterns, which include year-round training, participation on multiple teams of the same sport, and focused participation in a single sport at a young age, are at high levels. The need for this type of early specialized training in young athletes is currently under debate. Evidence Acquisition: Nonsystematic review. Study Design: Clinical review. Level of Evidence: Level 4. Conclusion: Sports sp...

Single-cell-type quantitative proteomic and ionomic analysis of epidermal bladder cells from the halophyte model plant Mesembryanthemum crystallinum to identify salt-responsive proteins

OpenAIRE

Barkla, Bronwyn J.; Vera-Estrella, Rosario; Raymond, Carolyn

2016-01-01

Background Epidermal bladder cells (EBC) are large single-celled, specialized, and modified trichomes found on the aerial parts of the halophyte Mesembryanthemum crystallinum. Recent development of a simple but high throughput technique to extract the contents from these cells has provided an opportunity to conduct detailed single-cell-type analyses of their molecular characteristics at high resolution to gain insight into the role of these cells in the salt tolerance of the plant. Results In...

SPECIALIZED COURTS OF THE EUROPEAN UNION

Directory of Open Access Journals (Sweden)

Ioana Nely Militaru

2013-11-01

Full Text Available Treaty of Lisbon entered into force on 1 December 2009, improved functioning judicial system European Union ( EU. Court of Justice of the EU has been reformed, said Treaty changing the EU courts so very name : Court of Justice of the EU, the Court referred to above, the Court of First Instance, and specialized courts, known previously, judicial panels. The paper shows the first part of his creation, composition and competence of the specialized courts, and as a manifestation of them in the second part examines the Civil Service Tribunal, the same point of view. EU specialized courts may be set up in specific areas, specializing in some technical disputes. These specialized courts have jurisdiction to hear and decide the cases in the first instance with the possibility that their decision subject to appeal to the General Court . In this context, to resolve disputes between the Union and its officials was established Tribunal.

Cell Towers and Songbirds

Science.gov (United States)

Klosterman, Michelle; Mesa, Jennifer; Milton, Katie

2009-01-01

This article describes how our common addiction to cell phones was used to launch a discussion about their use, impacts on the environment, and connections to issues of civic concern. By encouraging middle school science students to adopt the perspectives of special-interest groups debating communication tower restrictions designed to protect…

Update on small intestinal stem cells.

Science.gov (United States)

Tesori, Valentina; Puglisi, Maria Ausiliatrice; Lattanzi, Wanda; Gasbarrini, Giovanni Battista; Gasbarrini, Antonio

2013-08-07

Among somatic stem cells, those residing in the intestine represent a fascinating and poorly explored research field. Particularly, somatic stem cells reside in the small intestine at the level of the crypt base, in a constant balance between self-renewal and differentiation. Aim of the present review is to delve into the mechanisms that regulate the delicate equilibrium through which intestinal stem cells orchestrate intestinal architecture. To this aim, special focus will be addressed to identify the integrating signals from the surrounding niche, supporting a model whereby distinct cell populations facilitate homeostatic vs injury-induced regeneration.

Special Needs: Planning for Adulthood (Videos)

Medline Plus

Full Text Available ... Parents site Sitio para padres General Health Growth & Development Infections Diseases ... Special Needs: Planning for Adulthood (Video) KidsHealth / For Parents / Special Needs: ...

Stress: The Special Educator's Perspective.

Science.gov (United States)

Raschke, Donna; And Others

1988-01-01

The article describes approaches special education teachers can take to reduce stress including diet and exercise, relaxation techniques, use of social support systems, goal setting, time management, and networking. A survey of special education teachers found the use of humor the most common strategy for coping with stress. (DB)

Public Relations in Special Libraries.

Science.gov (United States)

Rutkowski, Hollace Ann; And Others

1991-01-01

This theme issue includes 11 articles on public relations (PR) in special libraries. Highlights include PR at the Special Libraries Association (SLA); sources for marketing research for libraries; developing a library image; sample PR releases; brand strategies for libraries; case studies; publicizing a consortium; and a bibliography of pertinent…

Feminist Therapy: A New Specialization

Science.gov (United States)

Regan, Carole Bennett

1975-01-01

A new area of concentration, if not of specialization, has recently developed, roughly termed "feminist" therapy or counseling. Whether or not it is a "legitimate" specialization, whether or not women should be counseled in a manner different from that of men, is a topic of current debate. (Author)

Stability, Specialization and Social Recognition

NARCIS (Netherlands)

Gilles, R.P.; Lazarova, E.A.; Ruys, P.H.M.

2006-01-01

Yang s theory of economic specialization under increasing returns to scale (Yang 2001) is a formal development of the fundamental Smith-Young theorem on the extent of the market and the social division of labor.In this theory specialization and, thus, the social division of labor is firmly embedded

Hydrostatic pressure cells development for X-ray and neutron experiments

International Nuclear Information System (INIS)

Passamai Junior, Jose Luis

2010-01-01

It was developed and built two pressure cell original models in order to be applied in X-ray elastic scattering (X-ray diffraction), X-ray absorption and neutron scattering experiments (neutron diffraction) under hydrostatic pressure. For the first two experimental cases, where X-ray beam is used, the pressure cell built with two B 4 C anvil mounted in a CuBe body. The B 4 C anvil was prepared at CTA research center in order to present an enhanced X-ray transparence and hardness. The special detail and advantage of the CuBe cell with B 4 C anvil is that this cell can be also used to measure de AC magnetic susceptibility in situ. This special characteristic is highlight as new concept of labeled here as multipurpose pressure cell. A second type of cell pressure was developed in order to be used in neutron elastic scattering experiments, specific in neutron diffraction experiments. The neutron cell pressure was developed using carbon fibers composite to improve the mechanical resistance a cylindrical geometry. The B 4 C pressure cells were available to researches in LNLS. The neutron pressure cell was given to research staff of IPEN Nuclear Reactor. This work show details and draws of these two types of hydrostatic pressure cells. (author)

The eyes of lanternfishes (Myctophidae, Teleostei): novel ocular specializations for vision in dim light.

Science.gov (United States)

de Busserolles, Fanny; Marshall, N Justin; Collin, Shaun P

2014-05-01

Lanternfishes are one of the most abundant groups of mesopelagic fishes in the world's oceans and play a critical role in biomass vertical turnover. Despite their importance, very little is known about their physiology or how they use their sensory systems to survive in the extreme conditions of the deep sea. In this study, we provide a comprehensive description of the general morphology of the myctophid eye, based on analysis of 53 different species, to understand better their visual capabilities. Results confirm that myctophids possess several visual adaptations for dim-light conditions, including enlarged eyes, an aphakic gap, a tapetum lucidum, and a pure rod retina with high densities of long photoreceptors. Two novel retinal specializations were also discovered. The first specialization is a fundal pigmentation in adult eyes, found within an isolated retinal region (typically central retina) composed of modified pigment epithelial cells, which we hypothesize to be the remnant of a more pronounced visual specialization important in larval stages. The second specialization is an aggregation of extracellular microtubular-like structures found within the sclerad region of the inner nuclear layer of the retina. We hypothesize that the marked interspecific differences in the hypertrophy of these microtubular-like structures may be related to inherent differences in visual function. A general interspecific variability in other parts of the eye is also revealed and examined in this study. The contribution of both ecology and phylogeny to the evolution of ocular specializations and vision in dim light are discussed. Copyright © 2013 Wiley Periodicals, Inc.

Quivers For Special Fuel Rods-Disposal Of Special Fuel Rods In CASTOR V Casks

International Nuclear Information System (INIS)

Bannani, Amin; Cebula, Wojciech; Buchmuller, Olga; Huggenberg, Roland; Helmut Kuhl

2015-01-01

While GNS casks of the CASTOR family are a suitable means to transfer fuel assemblies (FA) from the NPP to an interim dry storage site, Germanys phase-out of nuclear energy has triggered the demand for an additional solution to dispose of special fuel rods (SFR), normally remaining in the fuel pond until the final shutdown of the NPP. SFR are fuel rods that had to be removed from fuel assemblies mainly due to their special condition, e. g. damages in the cladding of the fuel rods which may have occurred during reactor operations. SFR are usually stored in the spent fuel pond after they are removed from the FA. The quiver for special fuel rods features a robust yet simple design, with a high mechanical stability, a reliable leak-tightness and large safety margins for future requirements on safety analysis. The quiver for special fuel rods can be easily adapted to a large variety of different damaged fuel rods and tailored to the specific need of the customer. The quiver for special fuel rods is adaptable e.g. in length and diameter for use in other types of transport and storage casks and is applicable in other countries as well. The overall concept presented here is a first of its kind solution for the disposal of SFRs via Castor V-casks. This provides an important precondition in achieving the status 'free from nuclear fuel' of the shut down German NPPs

Quivers For Special Fuel Rods-Disposal Of Special Fuel Rods In CASTOR V Casks

Energy Technology Data Exchange (ETDEWEB)

Bannani, Amin; Cebula, Wojciech; Buchmuller, Olga; Huggenberg, Roland [GNS, Essen (Germany); Helmut Kuhl [WTI, Julich (Germany)

2015-05-15

While GNS casks of the CASTOR family are a suitable means to transfer fuel assemblies (FA) from the NPP to an interim dry storage site, Germanys phase-out of nuclear energy has triggered the demand for an additional solution to dispose of special fuel rods (SFR), normally remaining in the fuel pond until the final shutdown of the NPP. SFR are fuel rods that had to be removed from fuel assemblies mainly due to their special condition, e. g. damages in the cladding of the fuel rods which may have occurred during reactor operations. SFR are usually stored in the spent fuel pond after they are removed from the FA. The quiver for special fuel rods features a robust yet simple design, with a high mechanical stability, a reliable leak-tightness and large safety margins for future requirements on safety analysis. The quiver for special fuel rods can be easily adapted to a large variety of different damaged fuel rods and tailored to the specific need of the customer. The quiver for special fuel rods is adaptable e.g. in length and diameter for use in other types of transport and storage casks and is applicable in other countries as well. The overall concept presented here is a first of its kind solution for the disposal of SFRs via Castor V-casks. This provides an important precondition in achieving the status 'free from nuclear fuel' of the shut down German NPPs.

Replication confers β cell immaturity.

Science.gov (United States)

Puri, Sapna; Roy, Nilotpal; Russ, Holger A; Leonhardt, Laura; French, Esra K; Roy, Ritu; Bengtsson, Henrik; Scott, Donald K; Stewart, Andrew F; Hebrok, Matthias

2018-02-02

Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication. In contrast, proliferation is robust in neonatal β cells that are functionally immature as defined by a lower set point for glucose-stimulated insulin secretion. Here we show that β-cell proliferation and immaturity are linked by tuning expression of physiologically relevant, non-oncogenic levels of c-Myc. Adult β cells induced to replicate adopt gene expression and metabolic profiles resembling those of immature neonatal β that proliferate readily. We directly demonstrate that priming insulin-producing cells to enter the cell cycle promotes a functionally immature phenotype. We suggest that there exists a balance between mature functionality and the ability to expand, as the phenotypic state of the β cell reverts to a less functional one in response to proliferative cues.

The Gap in Standards for Special Libraries.

Science.gov (United States)

Dodd, James Beaupre

1982-01-01

The issue of standards for special libraries is discussed, highlighting surveys conducted concerning the diversity of special libraries and salaries of members of the Special Libraries Association (SLA). Efforts of SLA's Standards and Statistics Committee are noted. Twenty references are listed. (EJS)

7 CFR 1753.68 - Purchasing special equipment.

Science.gov (United States)

2010-01-01

... 7 Agriculture 11 2010-01-01 2010-01-01 false Purchasing special equipment. 1753.68 Section 1753.68... AGRICULTURE TELECOMMUNICATIONS SYSTEM CONSTRUCTION POLICIES AND PROCEDURES Purchase and Installation of Special Equipment § 1753.68 Purchasing special equipment. (a) General. (1) Equipment purchases are...

Governor's Council on Disabilities and Special Education

Science.gov (United States)

State Employees Governor's Council on Disabilities and Special Education DHSS State of Alaska Home ; Governor's Council on Disabilities and Special Education Page Content Untitled Document Patrick Reinhart : follow GCDSE to 40404 The Governor's Council on Disabilities & Special Education is pleased to award

Perspective for special Gurdon issue for differentiation: can cell fusion inform nuclear reprogramming?

Science.gov (United States)

Burns, David; Blau, Helen M

2014-07-01

Nuclear reprogramming was first shown to be possible by Sir John Gurdon over a half century ago. The process has been revolutionized by the production of induced pluripotent cells by overexpression of the four transcription factors discovered by Shinya Yamanaka, which now enables mammalian applications. Yet, reprogramming by a few transcription factors remains incomplete and inefficient, whether to pluripotent or differentiated cells. We propose that a better understanding of mechanistic insights based on developmental principles gained from heterokaryon studies may inform the process of directing cell fate, fundamentally and clinically. Copyright © 2014 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

ON Bipolar Cells in Macaque Retina: Type-Specific Synaptic Connectivity with Special Reference to OFF Counterparts

Science.gov (United States)

Tsukamoto, Yoshihiko; Omi, Naoko

2016-01-01

To date, 12 macaque bipolar cell types have been described. This list includes all morphology types first outlined by Polyak (1941) using the Golgi method in the primate retina and subsequently identified by other researchers using electron microscopy (EM) combined with the Golgi method, serial section transmission EM (SSTEM), and immunohistochemical imaging. We used SSTEM for the rod-dense perifoveal area of macaque retina, reconfirmed ON (cone) bipolar cells to be classified as invaginating midget bipolar (IMB), diffuse bipolar (DB)4, DB5, DB6, giant bipolar (GB), and blue bipolar (BB) types, and clarified their type-specific connectivity. DB4 cells made reciprocal synapses with a kind of ON-OFF lateral amacrine cell, similar to OFF DB2 cells. GB cells contacted rods and cones, similar to OFF DB3b cells. Retinal circuits formed by GB and DB3b cells are thought to substantiate the psychophysical finding of fast rod signals in mesopic vision. DB6 cell output synapses were directed to ON midget ganglion (MG) cells at 70% of ribbon contacts, similar to OFF DB1 cells that directed 60% of ribbon contacts to OFF MG cells. IMB cells contacted medium- or long-wavelength sensitive (M/L-) cones but not short-wavelength sensitive (S-) cones, while BB cells contacted S-cones but not M/L-cones. However, IMB and BB dendrites had similar morphological architectures, and a BB cell contacting a single S-cone resembled an IMB cell. Thus, both IMB and BB may be the ON bipolar counterparts of the OFF flat midget bipolar (FMB) type, likewise DB4 of DB2, DB5 of DB3a, DB6 of DB1, and GB of DB3b OFF bipolar type. The ON DB plus GB, and OFF DB cells predominantly contacted M/L-cones and their outputs were directed mainly to parasol ganglion (PG) cells but also moderately to MG cells. BB cells directed S-cone-driven outputs almost exclusively to small bistratified ganglion (SBG) cells. Some FMB cells predominantly contacted S-cones and their outputs were directed to OFF MG cells. Thus, two

ICSSP 2015–Special Issue Introduction

DEFF Research Database (Denmark)

Pfahl, Dietmar; Kuhrmann, Marco; Bendraou, Reda

2016-01-01

Introduction to the Special Issue of the International Conference on Software and System Process......Introduction to the Special Issue of the International Conference on Software and System Process...

30 CFR 716.4 - Special bituminous coal mines.

Science.gov (United States)

2010-07-01

... 30 Mineral Resources 3 2010-07-01 2010-07-01 false Special bituminous coal mines. 716.4 Section... INTERIOR INITIAL PROGRAM REGULATIONS SPECIAL PERFORMANCE STANDARDS § 716.4 Special bituminous coal mines. (a) Definition. Special bituminous coal surface mines as used in this section means those bituminous...

Retroactive Stop Loss Special Pay

Science.gov (United States)

Pay (RSLSP), providing $500 for each month/partial month served in stop loss status. Service members served under stop loss must submit a claim for the special pay. Throughout the year, the services have or extension of service, became ineligible to receive retroactive stop loss special pay. There may be

46 CFR 190.01-15 - Special consideration.

Science.gov (United States)

2010-10-01

... 46 Shipping 7 2010-10-01 2010-10-01 false Special consideration. 190.01-15 Section 190.01-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) OCEANOGRAPHIC RESEARCH VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 190.01-15 Special consideration. (a) Special consideration will...

Floral Nectary Anatomy and Ultrastructure in Mycoheterotrophic Plant, Epipogium aphyllum Sw. (Orchidaceae

Directory of Open Access Journals (Sweden)

Emilia Święczkowska

2015-01-01

Full Text Available Epipogium aphyllum is a European-Asian obligatory mycoheterotrophic orchid containing no chlorophyll. Flowers are not resupinate with a sack-shape spur and cordate lip, which is divided into two parts: the basal (hypochile and distal one (epichile. The floral analysis provides strong evidence to conclude that nectar is secreted on the upper surface of pink-coloured papillate ridges and epidermal (adaxial cells at different place in spur, especially at the apex. The exudation on papillae has been observed through the entire anthesis and it has been stained on polysaccharides, proteins, and lipids. The dense cytoplasm of papillae contains profuse endoplasmic reticulum, plentiful vesicles (bigger ones with tannin-like materials, numerous mitochondria, sometimes dictyosomes, starch grains, and plastids with tubular structures. The large electron-dense bodies in cell walls are structurally the same as tannin-like materials from vesicles that are in contact with plasmalemma. The rupture of thin layer of swelled cuticle is caused by pressure of gathered substances exuded due to granulocrine secretion. The idioblasts with raphides occur mainly in tepals tissue. The dynamic changes of the nectar exudation, released through endocrine secretion, have been noticeable during the anthesis: both on the lip and inside the spur. The nectar secretion is not dependent on the colour form of E. aphyllum blooming shoots. The floral biology and ultrastructure differ from mycoheterotrophic plants known up to date.

Techniques for remote maintenance of in-cell material-handling system in the HFEF/N main cell

International Nuclear Information System (INIS)

Tobias, D.A.; Frickey, C.A.

1975-01-01

Operations in the main cell of HFEF/N have required development of remote handling equipment and unique techniques for maintaining the in-cell material-handling system. Specially designed equipment is used to remove a disabled crane or electromechanical manipulator bridge from its support rails and place it on floor stands for repair or maintenance. Support areas for the main cell, such as the spray chamber and hot repair area, provide essential decontamination, repair, and staging areas for the in-cell material-handling-system equipment and tools. A combined engineering and technical effort in upgrading existing master-slave manipulators has definitely reduced the requirements for their maintenance. The cell is primarily for postirradiation examination of LMFBR materials and fuel elements

Sports Specialization, Part II

Science.gov (United States)

Myer, Gregory D.; Jayanthi, Neeru; DiFiori, John P.; Faigenbaum, Avery D.; Kiefer, Adam W.; Logerstedt, David; Micheli, Lyle J.

2016-01-01

Context: Many coaches, parents, and children believe that the best way to develop elite athletes is for them to participate in only 1 sport from an early age and to play it year-round. However, emerging evidence to the contrary indicates that efforts to specialize in 1 sport may reduce opportunities for all children to participate in a diverse year-round sports season and can lead to lost development of lifetime sports skills. Early sports specialization may also reduce motor skill development and ongoing participation in games and sports as a lifestyle choice. The purpose of this review is to employ the current literature to provide evidence-based alternative strategies that may help to optimize opportunities for all aspiring young athletes to maximize their health, fitness, and sports performance. Evidence Acquisition: Nonsystematic review with critical appraisal of existing literature. Study Design: Clinical review. Level of Evidence: Level 4. Conclusion: Based on the current evidence, parents and educators should help provide opportunities for free unstructured play to improve motor skill development and youth should be encouraged to participate in a variety of sports during their growing years to influence the development of diverse motor skills. For those children who do choose to specialize in a single sport, periods of intense training and specialized sport activities should be closely monitored for indicators of burnout, overuse injury, or potential decrements in performance due to overtraining. Last, the evidence indicates that all youth should be involved in periodized strength and conditioning (eg, integrative neuromuscular training) to help them prepare for the demands of competitive sport participation, and youth who specialize in a single sport should plan periods of isolated and focused integrative neuromuscular training to enhance diverse motor skill development and reduce injury risk factors. Strength of Recommendation Taxonomy (SORT): B. PMID

Fluorescence lifetime imaging of induced pluripotent stem cells

Science.gov (United States)

Uchugonova, Aisada; Batista, Ana; König, Karsten

2014-02-01

The multiphoton FLIM tomograph MPTflex with its flexible scan head, articulated arm, and the tunable femtosecond laser source was employed to study cell monolayers and 3D cell clusters. FLIM was performed with 250 ps temporal resolution and submicron special resolution using time-correlated single photon counting. The autofluorescence based on NAD(P)H and flavins/flavoproteins has been measured in mouse embryonic fibroblasts, induced pluripotent stem cells (iPS cells) originated from mouse embryonic fibroblasts and non-proliferative mouse embryonic fibroblasts.

Imperative-program transformation by instrumented-interpreter specialization

DEFF Research Database (Denmark)

Debois, Søren

2008-01-01

We describe how to implement strength reduction, loop-invariant code motion and loop quasi-invariant code motion by specializing instrumented interpreters. To curb code duplication intrinsic to such specialization, we introduce a new program transformation, rewinding, which uses Moore-automata mi......We describe how to implement strength reduction, loop-invariant code motion and loop quasi-invariant code motion by specializing instrumented interpreters. To curb code duplication intrinsic to such specialization, we introduce a new program transformation, rewinding, which uses Moore...

27 CFR 479.32 - Special (occupational) tax rates.

Science.gov (United States)

2010-04-01

... 27 Alcohol, Tobacco Products and Firearms 3 2010-04-01 2010-04-01 false Special (occupational) tax..., AND CERTAIN OTHER FIREARMS Special (Occupational) Taxes § 479.32 Special (occupational) tax rates. (a) Prior to January 1, 1988, the special (occupational) tax rates were as follows: Per year or fraction...

Distributed Shared Memory for the Cell Broadband Engine (DSMCBE)

DEFF Research Database (Denmark)

Larsen, Morten Nørgaard; Skovhede, Kenneth; Vinter, Brian

2009-01-01

in and out of non-coherent local storage blocks for each special processor element. In this paper we present a software library, namely the Distributed Shared Memory for the Cell Broadband Engine (DSMCBE). By using techniques known from distributed shared memory DSMCBE allows programmers to program the CELL...

46 CFR 92.01-15 - Special consideration.

Science.gov (United States)

2010-10-01

... 46 Shipping 4 2010-10-01 2010-10-01 false Special consideration. 92.01-15 Section 92.01-15 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CARGO AND MISCELLANEOUS VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 92.01-15 Special consideration. (a) Special consideration will be...

Intensity of Tuta absoluta (Meyrick, 1917 (Lepidoptera: Gelechiidae and Liriomyza spp. (Diptera: Agromyzidae attacks on Lycopersicum esculentum Mill. Leaves Intensidade de ataque de Tuta absoluta (Meyrick, 1917 (Lepidoptera: Gelechiidae e de Liriomyza spp. (Diptera: Agromyzidae em folhas de Lycopersicum esculentum Mill.

Directory of Open Access Journals (Sweden)

Germano Leão Demolin Leite

2004-02-01

Full Text Available The objective of this study was to determine the effect of height of leaves in the canopy of plants, leaf organic compounds, concentrations of leaf nitrogen and potassium, leaf trichomes and cristalliferous idioblasts densities on the attack intensity of three tomato (Lycopersicon esculentum Mill. cv. Santa Clara crops by Tuta absoluta (Meyrick (Lepidoptera: Gelechiidae and Liriomyza spp. (Diptera: Agromyzidae, under field conditions. The experimental design was arranged in randomized blocks, with three replications, each being one tomato crop. Analysis of variance and the Tukey’s multiple range test (5% significance were used to test the effect of canopy height, trichome and cristalliferous idioblasts densities on the number of mines produced by T. absoluta and Liriomyza spp. and on the number of T. absoluta eggs. Pearson’s correlation (5% significance was used to evaluate the relationships between leaf organic compounds, leaf N and K concentrations, leaf trichome and cristalliferous idioblasts densities and the number of mines produced by T. absoluta and Liriomyza spp. and the number of T. absoluta eggs. Highest insect attack occurred in the final stage of the culture. A higher number of Liriomyza spp. mines/leaf was recorded in the lower (1.50 than in the upper (0.02 level of the tomato plants, the opposite was observed for the number of T. absoluta eggs/leaf (0.13 and 0.57, respectively. The number of T. absoluta mines/leaf concentrated more on the median (10.23 and apical regions (8.63 than on the basal (4.93. No significant effect of the trichomes and cristalliferous idioblasts densities of leaves was noted on T. absoluta and Liriomyza ssp. populations. Apparently, the terpenes affected oviposition of T. absoluta while leaf potassium affected Liriomyza spp. attack.Objetivou-se com este estudo determinar as influências da posição das folhas no dossel das plantas, dos compostos orgânicos foliares, das concentrações de nitrogênio e

A simple solution to type specialization

DEFF Research Database (Denmark)

Danvy, Olivier

1998-01-01

Partial evaluation specializes terms, but traditionally this specialization does not apply to the type of these terms. As a result, specializing, e.g., an interpreter written in a typed language, which requires a “universal” type to encode expressible values, yields residual programs with type tags...... all over. Neil Jones has stated that getting rid of these type tags was an open problem, despite possible solutions such as Torben Mogensen's “constructor specialization.” To solve this problem, John Hughes has proposed a new paradigm for partial evaluation, “Type Specialization”, based on type...... from the universal type to the specific type of the residual program. Standard partial evaluation then yields a residual program without type tags, simply and efficiently....

Inclusive Special Education: Development of a New Theory for the Education of Children with Special Educational Needs and Disabilities

Science.gov (United States)

Hornby, Garry

2015-01-01

Inclusive education and special education are based on different philosophies and provide alternative views of education for children with special educational needs and disabilities. They are increasingly regarded as diametrically opposed in their approaches. This article presents a theory of "inclusive special education" that comprises…

Sports specialization in young athletes: evidence-based recommendations.

Science.gov (United States)

Jayanthi, Neeru; Pinkham, Courtney; Dugas, Lara; Patrick, Brittany; Labella, Cynthia

2013-05-01

Sports specialization is intense training in 1 sport while excluding others. Sports specialization in early to middle childhood has become increasingly common. While most experts agree that some degree of sports specialization is necessary to achieve elite levels, there is some debate as to whether such intense practice time must begin during early childhood and to the exclusion of other sports to maximize potential for success. There is a concern that sports specialization before adolescence may be deleterious to a young athlete. PubMed and OVID were searched for English-language articles from 1990 to 2011 discussing sports specialization, expert athletes, or elite versus novice athletes, including original research articles, consensus opinions, and position statements. For most sports, there is no evidence that intense training and specialization before puberty are necessary to achieve elite status. Risks of early sports specialization include higher rates of injury, increased psychological stress, and quitting sports at a young age. Sports specialization occurs along a continuum. Survey tools are being developed to identify where athletes fall along the spectrum of specialization. Some degree of sports specialization is necessary to develop elite-level skill development. However, for most sports, such intense training in a single sport to the exclusion of others should be delayed until late adolescence to optimize success while minimizing injury, psychological stress, and burnout.

Current Uses of Artificial Intelligence in Special Education. Abstract XI: Research & Resources on Special Education.

Science.gov (United States)

ERIC Clearinghouse on Handicapped and Gifted Children, Reston, VA.

Summarized are two reports of a federally funded project on the use of artificial intelligence in special education. The first report, "Artificial Intelligence Applications in Special Education: How Feasible?," by Alan Hofmeister and Joseph Ferrara, provides information on the development and evaluation of a series of prototype systems in special…

Special Needs: Planning for Adulthood (Videos)

Medline Plus

Full Text Available ... learn about everything from financial and health care benefits to employment and housing options. ... Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

39 CFR 122.1 - Ancillary special services.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Ancillary special services. 122.1 Section 122.1 Postal Service UNITED STATES POSTAL SERVICE POST OFFICE SERVICES [DOMESTIC MAIL] SERVICE STANDARDS FOR MARKET-DOMINANT SPECIAL SERVICES PRODUCTS § 122.1 Ancillary special services. (a) For the market-dominant...

46 CFR 72.01-20 - Special consideration.

Science.gov (United States)

2010-10-01

... 46 Shipping 3 2010-10-01 2010-10-01 false Special consideration. 72.01-20 Section 72.01-20 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) PASSENGER VESSELS CONSTRUCTION AND ARRANGEMENT Hull Structure § 72.01-20 Special consideration. (a) Special consideration will be given to the...

Introduction to "PIQ"'s Special Ethics Section.

Science.gov (United States)

Hatcher, Tim

2003-01-01

Introduces "Performance Improvement Quarterly's" special section on ethics. The focus of this special section is to explore ethics and the field of human performance improvement in a broad sense by encouraging an examination of ethical concepts and responsibilities in the profession. This special section includes three critical views of…

Three-dimensional dynamic fabrication of engineered cartilage based on chitosan/gelatin hybrid hydrogel scaffold in a spinner flask with a special designed steel frame

International Nuclear Information System (INIS)

Song, Kedong; Li, Liying; Li, Wenfang; Zhu, Yanxia; Jiao, Zeren; Lim, Mayasari; Fang, Meiyun; Shi, Fangxin; Wang, Ling; Liu, Tianqing

2015-01-01

Cartilage transplantation using in vitro tissue engineered cartilage is considered a promising treatment for articular cartilage defects. In this study, we assessed the advantages of adipose derived stem cells (ADSCs) combined with chitosan/gelatin hybrid hydrogel scaffolds, which acted as a cartilage biomimetic scaffold, to fabricate a tissue engineered cartilage dynamically in vitro and compared this with traditional static culture. Physical properties of the hydrogel scaffolds were evaluated and ADSCs were inoculated into the hydrogel at a density of 1 × 10 7 cells/mL and cultured in a spinner flask with a special designed steel framework and feed with chondrogenic inductive media for two weeks. The results showed that the average pore size, porosity, swelling rate and elasticity modulus of hybrid scaffolds with good biocompatibility were 118.25 ± 19.51 μm, 82.60 ± 2.34%, 361.28 ± 0.47% and 61.2 ± 0.16 kPa, respectively. ADSCs grew well in chitosan/gelatin hybrid scaffold and successfully differentiated into chondrocytes, showing that the scaffolds were suitable for tissue engineering applications in cartilage regeneration. Induced cells cultivated in a dynamic spinner flask with a special designed steel frame expressed more proteoglycans and the cell distribution was much more uniform with the scaffold being filled mostly with extracellular matrix produced by cells. A spinner flask with framework promoted proliferation and chondrogenic differentiation of ADSCs within chitosan/gelatin hybrid scaffolds and accelerated dynamic fabrication of cell–hydrogel constructs, which could be a selective and good method to construct tissue engineered cartilage in vitro. - Highlights: • ADSCs/hybrid scaffold constructs are dynamically fabricated in a spinner flask with a special framework. • Inside convection in spinner flask made enough supplement of oxygen and nutrients far beyond the depth of passive diffusion. • 3D culture environment accelerated mass

Three-dimensional dynamic fabrication of engineered cartilage based on chitosan/gelatin hybrid hydrogel scaffold in a spinner flask with a special designed steel frame

Energy Technology Data Exchange (ETDEWEB)

Song, Kedong, E-mail: kedongsong@dlut.edu.cn [State Key Laboratory of Fine Chemicals, Dalian R& D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024 (China); Li, Liying; Li, Wenfang [State Key Laboratory of Fine Chemicals, Dalian R& D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024 (China); Zhu, Yanxia [Anti-Ageing and Regenerative Medicine Centre, Shenzhen University, 3688 Nanhai Avenue, Shenzhen 518060 Guangdong (China); Jiao, Zeren [State Key Laboratory of Fine Chemicals, Dalian R& D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024 (China); Lim, Mayasari [Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637457 (Singapore); Fang, Meiyun [Department of Hematology, First Affiliated Hospital, Dalian Medical University, Dalian 116011 (China); Shi, Fangxin [Department of Oncology, First Affiliated Hospital of Dalian Medical University, Dalian 116011 (China); Wang, Ling, E-mail: whwl@hotmail.com [Department of Obstetrics and Gynecology, First Affiliated Hospital, Dalian Medical University, Dalian 116011 (China); Liu, Tianqing, E-mail: liutq@dlut.edu.cn [State Key Laboratory of Fine Chemicals, Dalian R& D Center for Stem Cell and Tissue Engineering, Dalian University of Technology, Dalian 116024 (China)

2015-10-01

Cartilage transplantation using in vitro tissue engineered cartilage is considered a promising treatment for articular cartilage defects. In this study, we assessed the advantages of adipose derived stem cells (ADSCs) combined with chitosan/gelatin hybrid hydrogel scaffolds, which acted as a cartilage biomimetic scaffold, to fabricate a tissue engineered cartilage dynamically in vitro and compared this with traditional static culture. Physical properties of the hydrogel scaffolds were evaluated and ADSCs were inoculated into the hydrogel at a density of 1 × 10{sup 7} cells/mL and cultured in a spinner flask with a special designed steel framework and feed with chondrogenic inductive media for two weeks. The results showed that the average pore size, porosity, swelling rate and elasticity modulus of hybrid scaffolds with good biocompatibility were 118.25 ± 19.51 μm, 82.60 ± 2.34%, 361.28 ± 0.47% and 61.2 ± 0.16 kPa, respectively. ADSCs grew well in chitosan/gelatin hybrid scaffold and successfully differentiated into chondrocytes, showing that the scaffolds were suitable for tissue engineering applications in cartilage regeneration. Induced cells cultivated in a dynamic spinner flask with a special designed steel frame expressed more proteoglycans and the cell distribution was much more uniform with the scaffold being filled mostly with extracellular matrix produced by cells. A spinner flask with framework promoted proliferation and chondrogenic differentiation of ADSCs within chitosan/gelatin hybrid scaffolds and accelerated dynamic fabrication of cell–hydrogel constructs, which could be a selective and good method to construct tissue engineered cartilage in vitro. - Highlights: • ADSCs/hybrid scaffold constructs are dynamically fabricated in a spinner flask with a special framework. • Inside convection in spinner flask made enough supplement of oxygen and nutrients far beyond the depth of passive diffusion. • 3D culture environment accelerated mass

An assessment of plant biointrusion at the Uranium Mill Tailings Remedial Action Project rock-covered disposal cells

International Nuclear Information System (INIS)

1990-10-01

This study is one of a number of special studies that have been conducted regarding various aspects of the Uranium Mill Tailings Remedial Action (UMTRA) Project. This special study was proposed following routine surveillance and maintenance surveys and observations reported in a special study of vegetative covers (DOE, 1988), in which plants were observed growing up through the rock erosion layer at recently completed disposal cells. Some of the plants observed were deep-rooted woody species, and questions concerning root intrusion into disposal cells and the need to control plant growth were raised. The special study discussed in this report was designed to address some of the ramifications of plant growth on disposal cells that have rock covers. The NRC has chosen rock covers over vegetative covers in the arid western United States because licenses cannot substantiate that the vegetative covers ''will be significantly greater than 30 percent and preferably 70 percent,'' which is the amount of ''vegetation required to reduce flow to a point of stability.'' The potential impacts of vegetation growing in rock covers are not addressed by the NRC (1990). The objectives, then, of this study were to determine the species of plants growing on two rock-covered disposal cells, study the rooting pattern of plants on these cells, and identify possible impacts of plant root penetration on these and other UMTRA Project rock-covered cells

38 CFR 61.41 - Special needs grants application.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Special needs grants... (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.41 Special needs grants application. (a) To apply for a special needs grant, an applicant must obtain from VA a special needs grant application...

Sports Specialization, Part II: Alternative Solutions to Early Sport Specialization in Youth Athletes.

Science.gov (United States)

Myer, Gregory D; Jayanthi, Neeru; DiFiori, John P; Faigenbaum, Avery D; Kiefer, Adam W; Logerstedt, David; Micheli, Lyle J

2016-01-01

Many coaches, parents, and children believe that the best way to develop elite athletes is for them to participate in only 1 sport from an early age and to play it year-round. However, emerging evidence to the contrary indicates that efforts to specialize in 1 sport may reduce opportunities for all children to participate in a diverse year-round sports season and can lead to lost development of lifetime sports skills. Early sports specialization may also reduce motor skill development and ongoing participation in games and sports as a lifestyle choice. The purpose of this review is to employ the current literature to provide evidence-based alternative strategies that may help to optimize opportunities for all aspiring young athletes to maximize their health, fitness, and sports performance. Nonsystematic review with critical appraisal of existing literature. Clinical review. Level 4. Based on the current evidence, parents and educators should help provide opportunities for free unstructured play to improve motor skill development and youth should be encouraged to participate in a variety of sports during their growing years to influence the development of diverse motor skills. For those children who do choose to specialize in a single sport, periods of intense training and specialized sport activities should be closely monitored for indicators of burnout, overuse injury, or potential decrements in performance due to overtraining. Last, the evidence indicates that all youth should be involved in periodized strength and conditioning (eg, integrative neuromuscular training) to help them prepare for the demands of competitive sport participation, and youth who specialize in a single sport should plan periods of isolated and focused integrative neuromuscular training to enhance diverse motor skill development and reduce injury risk factors. B. © 2015 The Author(s).

Ouabain modulates cell contacts as well as functions that depend on cell adhesion.

Science.gov (United States)

Larre, Isabel; Contreras, Ruben G; Cereijido, Marcelino

2011-01-01

Ouabain, a toxic of vegetal origin used for centuries to treat heart failure, has recently been demonstrated to have an endogenous counterpart, most probably ouabain itself, which behaves as a hormone. Therefore, the challenge now is to discover the physiological role of hormone ouabain. We have recently shown that it modulates cell contacts such as gap junctions, which communicate neighboring cells, as well as tight junctions (TJs), which are one of the two differentiated features of epithelial cells, the other being apical/basolateral polarity. The importance of cell contacts can be hardly overestimated, since the most complex object in the universe, the brain, assembles itself depending on what cells contacts what other(s) how, when, and how is the molecular composition and special arrangement of the contacts involved. In the present chapter, we detail the protocols used to demonstrate the effect of ouabain on the molecular structure and functional properties of one of those cell-cell contacts: the TJ.

Colorectal cancer stem cells.

Science.gov (United States)

Salama, Paul; Platell, Cameron

2009-10-01

Somatic stem cells reside at the base of the crypts throughout the colonic mucosa. These cells are essential for the normal regeneration of the colonic epithelium. The stem cells reside within a special 'niche' comprised of intestinal sub-epithelial myofibroblasts that tightly control their function. It has been postulated that mutations within these adult colonic stem cells may induce neoplastic changes. Such cells can then dissociate from the epithelium and travel into the mesenchyme and thus form invasive cancers. This theory is based on the observation that within a colon cancer, less than 1% of the neoplastic cells have the ability to regenerate the tumour. It is this group of cells that exhibits characteristics of colonic stem cells. Although anti-neoplastic agents can induce remissions by inhibiting cell division, the stem cells appear to be remarkably resistant to both standard chemotherapy and radiotherapy. These stem cells may therefore persist after treatment and form the nucleus for cancer recurrence. Hence, future treatment modalities should focus specifically on controlling the cancer stem cells. In this review, we discuss the biology of normal and malignant colonic stem cells.

Special Section on Coloured Petri Nets

DEFF Research Database (Denmark)

1998-01-01

Special section on coloured Petri nets, their basic concepts, analysis methods, tool support and industrial applications.......Special section on coloured Petri nets, their basic concepts, analysis methods, tool support and industrial applications....

Editorial Introduction [to Female Germ Cells: Biology and Genetic Risk

Science.gov (United States)

This is an editorial introduction to the special issue of utation Research, titled, emale Germ Cells: Biology and Genetic isk, which is an attempt to present a collection of papers that emphasize the distinct properties of female germ cells and their characteristic response to mu...

Nonlinear generalization of special relativity

International Nuclear Information System (INIS)

Winterberg, F.

1985-01-01

In Poincares axiomatic formulation special relativity is a derived consequence of a true Lorentz contraction, for a rod in absolute motion through a substratum. Furthermore, Lorentz had shown that the rod contraction can be understood by an inverse square law interaction and therefore special relativity derived from more fundamental principles. The derivation by Lorentz shows that the root of the divergence problems is the singular inverse square law. By replacing the inverse square law with a regular one through the introduction of a finite length, the author has succeeded in deriving a nonlinear generalization of special relativity which eliminates all infinities. Besides the relative velocities, these nonlinear transformation equations also contain absolute velocities against a substratum, but in the limit of small energies they go over into the linear Lorentz transformations. Depending on the smallness of the fundamental length, departures from special relativity can be observed only at very high energies. The theorem that the velocity of light is the same in all reference systems still holds and likewise the conservation laws for energy and momentum

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Staying Safe Videos for Educators Search English Español Special Needs: Planning for Adulthood (Video) KidsHealth / For Parents / Special Needs: Planning for Adulthood (Video) Print Young adults with ...

Identification of human tissue cross-presenting dendritic cells

OpenAIRE

Haniffa, Muzlifah; Collin, Matthew; Ginhoux, Florent

2013-01-01

Dendritic cells (DCs) are a heterogeneous group of functionally specialized antigen-presenting cells. We recently characterized the human tissue cross-presenting DCs and aligned the human and mouse DC subsets. Our findings will facilitate the translation of murine DC studies to the human setting and aid the design of DC-based vaccine strategies for infection and cancer immunotherapy.

Extracellular Matrix as a Regulator of Epidermal Stem Cell Fate.

Science.gov (United States)

Chermnykh, Elina; Kalabusheva, Ekaterina; Vorotelyak, Ekaterina

2018-03-27

Epidermal stem cells reside within the specific anatomic location, called niche, which is a microenvironment that interacts with stem cells to regulate their fate. Regulation of many important processes, including maintenance of stem cell quiescence, self-renewal, and homeostasis, as well as the regulation of division and differentiation, are common functions of the stem cell niche. As it was shown in multiple studies, extracellular matrix (ECM) contributes a lot to stem cell niches in various tissues, including that of skin. In epidermis, ECM is represented, primarily, by a highly specialized ECM structure, basement membrane (BM), which separates the epidermal and dermal compartments. Epidermal stem cells contact with BM, but when they lose the contact and migrate to the overlying layers, they undergo terminal differentiation. When considering all of these factors, ECM is of fundamental importance in regulating epidermal stem cells maintenance, proper mobilization, and differentiation. Here, we summarize the remarkable progress that has recently been made in the research of ECM role in regulating epidermal stem cell fate, paying special attention to the hair follicle stem cell niche. We show that the destruction of ECM components impairs epidermal stem cell morphogenesis and homeostasis. A deep understanding of ECM molecular structure as well as the development of in vitro system for stem cell maintaining by ECM proteins may bring us to developing new approaches for regenerative medicine.

Structure of gels layers with cells

Science.gov (United States)

Pokusaev, B. G.; Karlov, S. P.; Vyazmin, A. V.; Nekrasov, D. A.; Zakharov, N. S.; Khramtsov, D. P.; Skladnev, D. A.; Tyupa, D. V.

2017-11-01

The structure of two-layer agarose gels containing yeast cells is investigated experimentally by spectrometry, to shed a light on the theoretical foundations for the development of bioreactors by the method of 3D bioprinting. Due to division, cells overcome the layer of the dispersion phase separating successively applied layers of the agarose gel. However a gel layer of 100 μm thick with a high concentration of silver nanoparticles completely excludes the infiltration of yeast cells through it. A special sort of agarose is suggested where the concentration of silver nanoparticles formed by cells from salt of silver can serve as an indicator of the state of the yeast cells in the volume of the gel.

Reaction thresholds in doubly special relativity

International Nuclear Information System (INIS)

Heyman, Daniel; Major, Seth; Hinteleitner, Franz

2004-01-01

Two theories of special relativity with an additional invariant scale, 'doubly special relativity', are tested with calculations of particle process kinematics. Using the Judes-Visser modified conservation laws, thresholds are studied in both theories. In contrast with some linear approximations, which allow for particle processes forbidden in special relativity, both the Amelino-Camelia and Magueijo-Smolin frameworks allow no additional processes. To first order, the Amelino-Camelia framework thresholds are lowered and the Magueijo-Smolin framework thresholds may be raised or lowered

Regulatory T cells in skin.

Science.gov (United States)

Ali, Niwa; Rosenblum, Michael D

2017-11-01

Foxp3 + CD4 + regulatory T (Treg) cells are a subset of immune cells that function to regulate tissue inflammation. Skin is one of the largest organs and is home to a large proportion of the body's Treg cells. However, relative to other tissues (such as the spleen and gastrointestinal tract) the function of Treg cells in skin is less well defined. Here, we review our understanding of how Treg cells migrate to skin and the cellular and molecular pathways required for their maintenance in this tissue. In addition, we outline what is known about the specialized functions of Treg cells in skin. Namely, the orchestration of stem cell-mediated hair follicle regeneration, augmentation of wound healing, and promoting adaptive immune tolerance to skin commensal microbes. A comprehensive understanding of the biology of skin Treg cells may lead to novel therapeutic approaches that preferentially target these cells to treat cutaneous autoimmunity, skin cancers and disorders of skin regeneration. © 2017 John Wiley & Sons Ltd.

Progressive maturation toward hematopoietic stem cells in the mouse embryo aorta

NARCIS (Netherlands)

Boisset, Jean-Charles; Clapes, Thomas; Klaus, Anna; Papazian, Natalie; Onderwater, Jos; Mommaas-Kienhuis, Mieke; Cupedo, Tom; Robin, Catherine

2015-01-01

Clusters of cells attached to the endothelium of the main embryonic arteries were first observed a century ago. Present in most vertebrate species, such clusters, or intraaortic hematopoietic clusters (IAHCs), derive from specialized hemogenic endothelial cells and contain the first few

Special Education in Mexico: One Community's Response.

Science.gov (United States)

Shepherd, Terry L.; Contreras, Diana; Brown, Randel

2002-01-01

This article looks at the history of special education in Mexico, discusses the emergence of special education programs, and examines a school for special education in Nuevo Laredo, Tamaulipas. The school provides vocational training for students with a variety of disabilities and has a partnership with the local maquiladora industry. (Contains 5…

Special Education Professional Development Needs in Zimbabwe

Science.gov (United States)

Chitiyo, Morgan; Hughes, Elizabeth M.; Changara, Darlington M.; Chitiyo, George; Montgomery, Kristen M.

2017-01-01

Since 1980 when Zimbabwe obtained political independence, special education has not received the same priority as the entire education system. One of the manifestations of this discrepancy is the shortage of qualified special education teachers in the country. In order to address this trend and promote the development of special education,…

29 CFR 215.7 - The Special Warranty.

Science.gov (United States)

2010-07-01

... 29 Labor 2 2010-07-01 2010-07-01 false The Special Warranty. 215.7 Section 215.7 Labor Regulations Relating to Labor OFFICE OF LABOR-MANAGEMENT STANDARDS, DEPARTMENT OF LABOR GUIDELINES, SECTION 5333(b), FEDERAL TRANSIT LAW § 215.7 The Special Warranty. (a) The Special Warranty mentioned in paragraph (b)(2...

Tolerogenic dendritic cells for regulatory T cell induction in man

Directory of Open Access Journals (Sweden)

Verena eRaker

2015-11-01

Full Text Available Dendritic cells are (DC highly specialized professional antigen-presenting cells (APC that regulate immune responses, maintaining the balance between tolerance and immunity. Mechanisms via which they can promote central and peripheral tolerance include clonal deletion, inhibition of memory T cell responses, T cell anergy and induction of regulatory T cells. These properties have led to the analysis of human tolerogenic DC as a therapeutic strategy for induction or re-establishment of tolerance. In the recent years, numerous protocols for the generation of human tolerogenic DC have been developed and their tolerogenic mechanisms, including induction of regulatory T cells, are relatively well understood. Phase I trials have been conducted in autoimmune disease, with results that emphasize the feasibility and safety of treatments with tolerogenic DC. Therefore, the scientific rationale for the use of tolerogenic DC therapy in the fields of transplantation medicine and allergic and autoimmune diseases is strong. This review will give an overview on efforts and protocols to generate human tolerogenic DC with focus on IL-10-modulated DC as inducers of regulatory T cells and discuss their clinical applications and challenges faced in further developing this form of immunotherapy.

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... the future, watch this video series together to learn about everything from financial and health care benefits to employment ... Respite Care for Your Child With Special Needs Special Education: Getting Help for ...

Retinal Ganglion Cell Distribution and Spatial Resolving Power in Deep-Sea Lanternfishes (Myctophidae)

KAUST Repository

De Busserolles, Fanny

2014-01-01

Topographic analyses of retinal ganglion cell density are very useful in providing information about the visual ecology of a species by identifying areas of acute vision within the visual field (i.e. areas of high cell density). In this study, we investigated the neural cell distribution in the ganglion cell layer of a range of lanternfish species belonging to 10 genera. Analyses were performed on wholemounted retinas using stereology. Topographic maps were constructed of the distribution of all neurons and both ganglion and amacrine cell populations in 5 different species from Nissl-stained retinas using cytological criteria. Amacrine cell distribution was also examined immunohistochemically in 2 of the 5 species using anti-parvalbumin antibody. The distributions of both the total neuron and the amacrine cell populations were aligned in all of the species examined, showing a general increase in cell density toward the retinal periphery. However, when the ganglion cell population was topographically isolated from the amacrine cell population, which comprised up to 80% of the total neurons within the ganglion cell layer, a different distribution was revealed. Topographic maps of the true ganglion cell distribution in 18 species of lanternfishes revealed well-defined specializations in different regions of the retina. Different species possessed distinct areas of high ganglion cell density with respect to both peak density and the location and/or shape of the specialized acute zone (i.e. elongated areae ventro-temporales, areae temporales and large areae centrales). The spatial resolving power was calculated to be relatively low (varying from 1.6 to 4.4 cycles per degree), indicating that myctophids may constitute one of the less visually acute groups of deep-sea teleosts. The diversity in retinal specializations and spatial resolving power within the family is assessed in terms of possible ecological functions and evolutionary history.

Special Teacher Stress: Its Product and Prevention. Special Report.

Science.gov (United States)

Bradfield, Robert H.; Fones, Donald M.

1985-01-01

Findings from a study involving 60 special education teachers examine characteristics of 20 Ss who scored highest and 20 who scored lowest on both job stress and life stress measures. Teachers are urged to begin relaxation training, exercise, emphasize positive attitudes, and maintain adequate diets. (CL)

Placing the special trains issue in perspective

International Nuclear Information System (INIS)

Rhoads, R.E.; DeSteese, J.G.; Loscutoff, W.V.; Chais, M.

1978-01-01

The Association of American Railroads has proposed changes in the way railroads handle shipments of radioactive materials. These changes are embodied in a set of recommended operating practices that would require shipments of spent fuel and radioactive waste to be moved only in special train service. The proposed operating practices include a 35 mph maximum speed restriction, a passing restriction and a no-other freight restriction. Shippers of radioactive materials oppose the imposition of these operating practices. The special train issue is currently being argued in hearings before the Interstate Commerce Commission. The history and current status of these hearings are reviewed. Pacific Northwest Laboratories has undertaken a study to provide perspective on the safety and economic factors related to the use of special trains for shipping spent fuel. The results of this study for the amount of spent fuel anticipated to be shipped in 1986 are reviewed. The safety analysis determines the frequencies and severities of accidents for conventional freight trains and compares these to extrapolated frequencies and severities of accidents for conventional freight trains subject to the special train operating restrictions. Results of the study show that the adoption of special trains and attendant operating restrictions has limited potential for improving safety during shipment. The economic analysis compares the cost of spent fuel shipments made by special train and by conventional freight train service.Results of the economics phase of the study show that the use of special trains will most likely increase the cost of shipments by about 50%, although under certain circumstances shipping costs for spent fuel by special trains may be up to 20% lower than by conventional train service. Possible methods to resolve the special train issue are explored

Microfluidic fuel cells and batteries

CERN Document Server

Kjeang, Erik

2014-01-01

Microfluidic fuel cells and batteries represent a special type of electrochemical power generators that can be miniaturized and integrated in a microfluidic chip. Summarizing the initial ten years of research and development in this emerging field, this SpringerBrief is the first book dedicated to microfluidic fuel cell and battery technology for electrochemical energy conversion and storage. Written at a critical juncture, where strategically applied research is urgently required to seize impending technology opportunities for commercial, analytical, and educational utility, the intention is

Host-Parasite Interactions from the Inside: Plant Reproductive Ontogeny Drives Specialization in Parasitic Insects.

Directory of Open Access Journals (Sweden)

Thomas Boivin

Full Text Available Host plant interactions are likely key drivers of evolutionary processes involved in the diversification of phytophagous insects. Granivory has received substantial attention for its crucial role in shaping the interaction between plants and their seed parasites, but fine-scale mechanisms explaining the role of host plant reproductive biology on specialization of seed parasites remain poorly described. In a comparative approach using plant histological techniques, we tested the hypotheses that different seed parasite species synchronize their life cycles to specific stages in seed development, and that the stage they target depends on major differences in seed development programs. In a pinaceous system, seed storage products are initiated before ovule fertilization and the wasps target the ovule's nucellus during megagametogenesis, a stage at which larvae may benefit from the by-products derived from both secreting cells and dying nucellar cells. In a cupressaceous system, oviposition activity peaks later, during embryogenesis, and the wasps target the ovule's megagametophyte where larvae may benefit from cell disintegration during embryogenesis. Our cytohistological approach shows for the first time how, despite divergent oviposition targets, different parasite species share a common strategy that consists of first competing for nutrients with developing plant structures, and then consuming these developed structures to complete their development. Our results support the prediction that seed developmental program is an axis for specialization in seed parasites, and that it could be an important parameter in models of their ecological and taxonomic divergence. This study provides the basis for further investigating the possibility of the link between plant ontogeny and pre-dispersal seed parasitism.

A Unification of Inheritance and Automatic Program Specialization

DEFF Research Database (Denmark)

Schultz, Ulrik Pagh

2004-01-01

, inheritance is used to control the automatic application of program specialization to class members during compilation to obtain an efficient implementation. This paper presents the language JUST, which integrates object-oriented concepts, block structure, and techniques from automatic program specialization......The object-oriented style of programming facilitates program adaptation and enhances program genericness, but at the expense of efficiency. Automatic program specialization can be used to generate specialized, efficient implementations for specific scenarios, but requires the program...... to be structured appropriately for specialization and is yet another new concept for the programmer to understand and apply. We have unified automatic program specialization and inheritance into a single concept, and implemented this approach in a modified version of Java named JUST. When programming in JUST...

Special Education Teacher Resilience: A Phenomenological Study of Factors Associated with Retention and Resilience of Highly Resilient Special Educators

Science.gov (United States)

Downing, Brienne

2017-01-01

Special education teachers are in high demand and greatly needed to meet the needs of the growing population of students qualified for special education services under the Individual with Disabilities Education Act (IDEA) of 2004. The increasing attrition rates of special education teachers are a social justice issue that needs attention. The…

Skin Stem Cells: At the Frontier Between the Laboratory and Clinical Practice. Part 1: Epidermal Stem Cells.

Science.gov (United States)

Pastushenko, I; Prieto-Torres, L; Gilaberte, Y; Blanpain, C

2015-11-01

Stem cells are characterized by their ability to self-renew and differentiate into the different cell lineages of their tissue of origin. The discovery of stem cells in adult tissues, together with the description of specific markers for their isolation, has opened up new lines of investigation, expanding the horizons of biomedical research and raising new hope in the treatment of many diseases. In this article, we review in detail the main characteristics of the stem cells that produce the specialized cells of the skin (epidermal, mesenchymal, and melanocyte stem cells) and their potential implications and applications in diseases affecting the skin. Part I deals with the principal characteristics and potential applications of epidermal stem cells in dermatology. Copyright © 2015 Elsevier España, S.L.U. and AEDV. All rights reserved.

Marketing in the Special Library Environment.

Science.gov (United States)

Powers, Janet E.

1995-01-01

Special libraries developed in response to a need for quick access to specific information. Integrated marketing in special libraries focuses the library toward strategic planning and offers the opportunity to develop more effective library services. (Author/AEF)

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... padres General Health Growth & Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & Behavior School & Family Life ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & Behavior School & Family Life First Aid & Safety Doctors & ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... them. While you help your tween or teen plan for the future, watch this video series together ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Parents site Sitio para padres General Health Growth & Development Infections Diseases & Conditions Pregnancy & Baby Nutrition & Fitness Emotions & ... for Health Insurance Finding Respite Care for Your Child With Special Needs Special Education: Getting Help for ...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Teens Teens site Sitio para adolescentes Body Mind Sexual Health Food & Fitness Diseases & Conditions Infections Drugs & Alcohol ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Conditions Pregnancy & Baby Nutrition & Fitness Emotions & Behavior School & Family Life First Aid & Safety Doctors & Hospitals Videos Recipes ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Food & Fitness Diseases & Conditions Infections Drugs & Alcohol School & Jobs Sports Expert Answers (Q&A) Staying Safe Videos ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

NKT cell self-reactivity: evolutionary master key of immune homeostasis?

DEFF Research Database (Denmark)

Navikas, Shohreh

2011-01-01

Complex immune responses have evolved to protect multicellular organisms against the invasion of pathogens. This has exerted strong developmental pressure for specialized functions that can also limit damage to self-tissue. Two arms of immunity, the innate and adaptive immune system, have evolved...... through evolution by higher vertebrates could be related to their central function as master regulators of immune homeostasis that in part is shared with regulatory T cells. Hypothetical views on how self-reactive NKT cells secure such a central role will also be proposed.......Complex immune responses have evolved to protect multicellular organisms against the invasion of pathogens. This has exerted strong developmental pressure for specialized functions that can also limit damage to self-tissue. Two arms of immunity, the innate and adaptive immune system, have evolved....... The recent finding of self-peptide reactivity of NKT cells in the context of CD1d, with capacity to regulate multiple autoimmune and inflammatory conditions, motivates the current proposal that self-reactive NKT cells might be the ancestral link between present NK and T cells. Their parallel selection...

Teaching Special Relativity without Calculus

Science.gov (United States)

Ruby, Lawrence

2009-01-01

In 2007 many AAPT members received a booklet that is the first chapter of a physics textbook available on a CD. This book espouses the new educational philosophy of teaching special relativity as the first item in the topic of mechanics. Traditionally, special relativity is part of one or more modern physics chapters at the end of the text, and…

Promoting Special Educator Teacher Retention

OpenAIRE

Jeremy E. Vittek

2015-01-01

This article is a critical review of the literature on special education teacher attrition and retention. The research focused on journal articles from 2004 to present. The results of the study helped define special educator attrition and retention. The major themes present in the findings were job satisfaction, administrative support, induction programs, and mentoring. The literature shows a clear need for comprehensi...

Special Education Finance in California

Science.gov (United States)

Hill, Laura; Warren, Paul; Murphy, Patrick; Ugo, Iwunze; Pathak, Aditi

2016-01-01

California's system of special education served about 718,000 students in 2014-15, or about 11.5 percent of the K-12 population. It is expensive, consuming some $12 billion in federal, state, and local dollars annually. Special education operates within a legal framework that sets it apart from the rest of the K-12 system. The state's enactment of…

The "special K" in kaizen.

Science.gov (United States)

McAtee, L F

1999-05-01

Do you want a strategy that guarantees the success of kaizen in your organization? This article will provide insights as to why one organization may succeed and another fails. Learn why the "Special K" is the difference. Idea will be presented on how to develop the "Special K" in others and ourselves. You will be challenged to become a "kaizener".

Orthogonal Polynomials and Special Functions

CERN Document Server

Assche, Walter

2003-01-01

The set of lectures from the Summer School held in Leuven in 2002 provide an up-to-date account of recent developments in orthogonal polynomials and special functions, in particular for algorithms for computer algebra packages, 3nj-symbols in representation theory of Lie groups, enumeration, multivariable special functions and Dunkl operators, asymptotics via the Riemann-Hilbert method, exponential asymptotics and the Stokes phenomenon. The volume aims at graduate students and post-docs working in the field of orthogonal polynomials and special functions, and in related fields interacting with orthogonal polynomials, such as combinatorics, computer algebra, asymptotics, representation theory, harmonic analysis, differential equations, physics. The lectures are self-contained requiring only a basic knowledge of analysis and algebra, and each includes many exercises.

NKT cell self-reactivity: evolutionary master key of immune homeostasis?

Science.gov (United States)

Issazadeh-Navikas, Shohreh

2012-04-01

Complex immune responses have evolved to protect multicellular organisms against the invasion of pathogens. This has exerted strong developmental pressure for specialized functions that can also limit damage to self-tissue. Two arms of immunity, the innate and adaptive immune systems, have evolved for quick, non-specific immune responses to pathogens and more efficient, long-lasting ones upon specific recognition of recurrent pathogens. Specialized cells have arisen as the sentinels of these functions, including macrophages, natural killer (NK), and T and B-lymphocytes. Interestingly, a population of immune cells that can exert both of these complex functions, NKT cells, not only share common functions but also exhibit shared cell surface markers of cells of both arms of the immune system. These features, in combination with sophisticated maintenance of immune homeostasis, will be discussed. The recent finding of self-peptide reactivity of NKT cells in the context of CD1d, with capacity to regulate multiple autoimmune and inflammatory conditions, motivates the current proposal that self-reactive NKT cells might be the ancestral link between present NK and T cells. Their parallel selection through evolution by higher vertebrates could be related to their central function as master regulators of immune homeostasis that in part is shared with regulatory T cells. Hypothetical views on how self-reactive NKT cells secure such a central role will also be proposed.

Transportation planning for planned special events

Science.gov (United States)

2011-05-01

Unique among planned special event activities are those events that carry the National Special Security Event (NSSE) designation. NSSEs occur with some frequency, with 35 of these events held between September 1998 and February 2010. These events inc...

Modern settlements in special needs education

DEFF Research Database (Denmark)

Ratner, Helene Gad

2016-01-01

. Settlements of this controversy govern whether the pupil or the educational institution becomes the main point of intervention. In Denmark, the particularities of settlements can be identified by juxtaposing the introduction of intelligence testing in the 1930s with the contemporary policy agenda of inclusion....... With intelligence testing, special needs education was to service children whose needs were seen as part of their human nature. Inclusion, in turn, assumes special needs to be stigmatizing cultural labels that need to be abandoned by changing school cultures. Drawing on actor-network theory we can approach......In the history of special needs education, the distinction between human nature and its social environment has been a controversial matter. The controversy regards whether special needs are primarily caused by the child's psycho-medical body or by cultural concepts of normality and deviance...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Kids site Sitio para niños How the Body Works Puberty & Growing Up Staying Healthy Staying Safe Recipes & ... Care for Your Child With Special Needs Special Education: Getting Help for Your Child Words to Know ( ...

Special Needs: Planning for Adulthood (Videos)

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Full Text Available ... Kids site Sitio para niños How the Body Works Puberty & Growing Up Staying Healthy Staying Safe Recipes & ... for Health Insurance Finding Respite Care for Your Child With Special Needs Special Education: Getting Help for ...

Interdisciplinary Perspectives on Special Operations Forces

DEFF Research Database (Denmark)

is the result of a research projec tproviding international interdisciplinary perspectives on special operations forces, based on three main themes: - Leading and organizing for strategic effect - Professional entrepreneurship and self-perceptions in special operations forces - Political and popular perceptions...

Cell-to-cell communication in plants, animals, and fungi: a comparative review.

Science.gov (United States)

Bloemendal, Sandra; Kück, Ulrich

2013-01-01

Cell-to-cell communication is a prerequisite for differentiation and development in multicellular organisms. This communication has to be tightly regulated to ensure that cellular components such as organelles, macromolecules, hormones, or viruses leave the cell in a precisely organized way. During evolution, plants, animals, and fungi have developed similar ways of responding to this biological challenge. For example, in higher plants, plasmodesmata connect adjacent cells and allow communication to regulate differentiation and development. In animals, two main general structures that enable short- and long-range intercellular communication are known, namely gap junctions and tunneling nanotubes, respectively. Finally, filamentous fungi have also developed specialized structures called septal pores that allow intercellular communication via cytoplasmic flow. This review summarizes the underlying mechanisms for intercellular communication in these three eukaryotic groups and discusses its consequences for the regulation of differentiation and developmental processes.

Unexpected exacerbations following initiation of disease-modifying drugs in neuromyelitis optica spectrum disorder: Which factor is responsible, anti-aquaporin 4 antibodies, B cells, Th1 cells, Th2 cells, Th17 cells, or others?

Science.gov (United States)

Kira, Jun-Ichi

2017-08-01

Some disease-modifying drugs for multiple sclerosis, which mainly act on T cells, are ineffective for neuromyelitis optica spectrum disorder and induce unexpected relapses. These include interferon beta, glatiramer acetate, fingolimod, natalizumab, and alemtuzumab. The cases reported here suggest that dimethyl fumarate, which reduces the number of Th1 and Th17 cells and induces IL-4-producing Th2 cells, is also unsuitable for neuromyelitis optica spectrum disorder, irrespective of anti-aquaporin 4 IgG serostatus. Although oral dimethyl fumarate with manageable adverse effects is easy to initiate in the early course of multiple sclerosis, special attention should be paid for atypical demyelinating cases.

Sandia National Laboratories: Careers: Special Programs

Science.gov (United States)

Program Master's Fellowship Program Wounded Warrior Career Development Program Careers Special Programs Special career opportunities for select individuals Join Sandia's workforce while receiving support and Laboratories' Affirmative Action Plan. Learn more about MFP. Wounded Warrior Career Development Program U.S

40 CFR 455.31 - Specialized definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Specialized definitions. 455.31 Section 455.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES....31 Specialized definitions. (a) “Metallo-organic active ingredients” means carbon containing active...

Stem cell biology and cell transplantation therapy in the retina.

Science.gov (United States)

Osakada, Fumitaka; Hirami, Yasuhiko; Takahashi, Masayo

2010-01-01

Embryonic stem (ES) cells, which are derived from the inner cell mass of mammalian blastocyst stage embryos, have the ability to differentiate into any cell type in the body and to grow indefinitely while maintaining pluripotency. During development, cells undergo progressive and irreversible differentiation into specialized adult cell types. Remarkably, in spite of this restriction in potential, adult somatic cells can be reprogrammed and returned to the naive state of pluripotency found in the early embryo simply by forcing expression of a defined set of transcription factors. These induced pluripotent stem (iPS) cells are molecularly and functionally equivalent to ES cells and provide powerful in vitro models for development, disease, and drug screening, as well as material for cell replacement therapy. Since functional impairment results from cell loss in most central nervous system (CNS) diseases, recovery of lost cells is an important treatment strategy. Although adult neurogenesis occurs in restricted regions, the CNS has poor potential for regeneration to compensate for cell loss. Thus, cell transplantation into damaged or diseased CNS tissues is a promising approach to treating various neurodegenerative disorders. Transplantation of photoreceptors or retinal pigment epithelium cells derived from human ES cells can restore some visual function. Patient-specific iPS cells may lead to customized cell therapy. However, regeneration of retinal function will require a detailed understanding of eye development, visual system circuitry, and retinal degeneration pathology. Here, we review the current progress in retinal regeneration, focusing on the therapeutic potential of pluripotent stem cells.

Israeli Special Libraries

Science.gov (United States)

Foster, Barbara

1974-01-01

Israel is sprinkled with a noteworthy representation of special libraries which run the gamut from modest kibbutz efforts to highly technical scientific and humanities libraries. A few examples are discussed here. (Author/CH)

Knowledge Enclosures, Forced Specializations and Investment Crisis

Directory of Open Access Journals (Sweden)

Filippo Belloc

2012-12-01

Full Text Available Like land before the industrial revolution, in the present global economy much knowledge is being enclosed in private hands. In this paper we argue that these enclosures have become a major factor in specialization among firms and among countries: both are forced to specialize in the fields that are not restricted by the enclosures of the others. We use data on 26 OECD countries over the 1978-2006 period. We estimate the effect of patents endowments of countries on their investment specialization across sectors and show that knowledge enclosures involve self-reinforcing innovation patterns. Moreover, we perform a structural change analysis and find that the TRIPs agreement has significantly strengthened the relationship between countries' patents specialization and investment specialization. We conclude by suggesting that stronger international patent protection may restrict global investment opportunities, and this may be one of the factors contributing to the present crisis.

Generation of thyroid follicular cells from pluripotent stem cells: Potential for regenerative medicine

Directory of Open Access Journals (Sweden)

Will eSewell

2014-06-01

Full Text Available Nearly 12 percent of the population in the United States will be afflicted with a thyroid related disorder during their lifetime. Common treatment approaches are tailored to the specific disorder and include surgery, radioactive iodine ablation, antithyroid drugs, thyroid hormone replacement, external beam radiation, and chemotherapy. Regenerative medicine endeavors to combat disease by replacing or regenerating damaged, diseased or dysfunctional body parts. A series of achievements in pluripotent stem cell research have transformed regenerative medicine in many ways by demonstrating repair of a number of body parts in mice, of which, the thyroid has now been inducted into this special group. Seminal work in pluripotent cells, namely embryonic stem cells and induced pluripotent stem cells, have made possible their path to becoming key tools and biological building blocks for cell-based regenerative medicine to combat the gamut of human diseases, including those affecting the thyroid.

76 FR 57625 - Special Conditions: Boeing Model 737-600, -700, -700C, -800, -900, and -900ER Series Airplanes...

Science.gov (United States)

2011-09-16

... addition, the substance of these special conditions has been subject to the public-comment process in...-battery cells use flammable liquid electrolytes. The electrolyte can serve as a source of fuel for an.... 25.1353 that are applicable to lithium batteries. The flammable-fluid fire-protection requirements of...

Focus on Membrane Differentiation and Membrane Domains in the Prokaryotic Cell

NARCIS (Netherlands)

Boekema, Egbert J.; Scheffers, Dirk-Jan; van Bezouwen, Laura S.; Bolhuis, Henk; Folea, I. Mihaela

2013-01-01

A summary is presented of membrane differentiation in the prokaryotic cell, with an emphasis on the organization of proteins in the plasma/cell membrane. Many species belonging to the Eubacteria and Archaea have special membrane domains and/or membrane proliferation, which are vital for different

Th17 Immune Cells in vivo: Friend or Foe? | Center for Cancer Research

Science.gov (United States)

Upon encountering an antigen, T cells bearing CD4+ (a helper marker) proliferate and become polarized. During this process, the cells produce specific signaling molecules called cytokines.  This signaling stimulates the T cells to become more specialized.  What results is the production of T cell subsets such as Th1, Th17, or others.

34 CFR 300.18 - Highly qualified special education teachers.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Highly qualified special education teachers. 300.18... SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE... special education teachers. (a) Requirements for special education teachers teaching core academic...

Very special relativity.

Science.gov (United States)

Cohen, Andrew G; Glashow, Sheldon L

2006-07-14

By very special relativity (VSR) we mean descriptions of nature whose space-time symmetries are certain proper subgroups of the Poincaré group. These subgroups contain space-time translations together with at least a two-parameter subgroup of the Lorentz group isomorphic to that generated by K(x) + J(y) and K(y)- J(x). We find that VSR implies special relativity (SR) in the context of local quantum field theory or of conservation. Absent both of these added hypotheses, VSR provides a simulacrum of SR for which most of the consequences of Lorentz invariance remain wholly or essentially intact, and for which many sensitive searches for departures from Lorentz invariance must fail. Several feasible experiments are discussed for which Lorentz-violating effects in VSR may be detectable.

Special polynomials associated with rational solutions of some hierarchies

International Nuclear Information System (INIS)

Kudryashov, Nikolai A.

2009-01-01

New special polynomials associated with rational solutions of the Painleve hierarchies are introduced. The Hirota relations for these special polynomials are found. Differential-difference hierarchies to find special polynomials are presented. These formulae allow us to search special polynomials associated with the hierarchies. It is shown that rational solutions of the Caudrey-Dodd-Gibbon, the Kaup-Kupershmidt and the modified hierarchy for these ones can be obtained using new special polynomials.

Specialization of mutualistic interaction networks decreases toward tropical latitudes

DEFF Research Database (Denmark)

Schleuning, M.; Fründ, J.; Klein, A.-M.

2012-01-01

that current conditions have a stronger effect on biotic specialization than historical community stability. Biotic specialization decreased with increasing local and regional plant diversity. This suggests that high specialization of mutualistic interactions is a response of pollinators and seed dispersers......] or differences in plant diversity [10, 11]. Thus, the direction of the latitudinal specialization gradient remains contentious. With an unprecedented global data set, we investigated how biotic specialization between plants and animal pollinators or seed dispersers is associated with latitude, past...... and contemporary climate, and plant diversity. We show that in contrast to expectation, biotic specialization of mutualistic networks is significantly lower at tropical than at temperate latitudes. Specialization was more closely related to contemporary climate than to past climate stability, suggesting...

Special Collections in ARL Libraries: A Discussion Report from the ARL Working Group on Special Collections

Science.gov (United States)

Association of Research Libraries, 2009

2009-01-01

This discussion report identifies key issues in the management of special collections material in the 21st century. The report uses a broad definition of "special collections," which encompasses distinctive material in all media and attendant library services. The group's main focus was on 19th- and 20th-century materials, including…

The medical physics specialization system in Poland.

Science.gov (United States)

Bulski, Wojciech; Kukołowicz, Paweł; Skrzyński, Witold

2016-07-01

This paper presents the situation of the profession of medical physicists in Poland. The official recognition of the profession of medical physicist in Polish legislation was in 2002. In recent years, more and more Universities which have Physics Faculties introduce a medical physics specialty. At present, there are about 15 Universities which offer such programmes. These Universities are able to graduate about 150 medical physicists per year. In 2002, the Ministry of Health introduced a programme of postgraduate specialization in medical physics along the same rules employed in the specialization of physicians in various branches of medicine. Five institutions, mostly large oncology centres, were selected as teaching institutions, based on their experience, the quality of the medical physics professionals, staffing levels, equipment availability, lecture halls, etc. The first cycle of the specialization programme started in 2006, and the first candidates completed their training at the end of 2008, and passed their official state exams in May 2009. As of January 2016, there are 196 specialized medical physicists in Poland. Another about 120 medical physicists are undergoing specialization. The system of training of medical physics professionals in Poland is well established. The principles of postgraduate training and specialization are well defined and the curriculum of the training is very demanding. The programme of specialization was revised in 2011 and is in accordance with EC and EFOMP recommendations. Copyright © 2016 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved.

40 CFR 455.61 - Special definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 29 2010-07-01 2010-07-01 false Special definitions. 455.61 Section 455.61 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND... § 455.61 Special definitions. Process wastewater, for this subpart, means all wastewater except for...

40 CFR 406.21 - Specialized definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Specialized definitions. 406.21 Section 406.21 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Dry Milling Subcategory § 406.21 Specialized definitions...

40 CFR 406.11 - Specialized definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Specialized definitions. 406.11 Section 406.11 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Corn Wet Milling Subcategory § 406.11 Specialized definitions...

40 CFR 406.41 - Specialized definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Specialized definitions. 406.41 Section 406.41 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Bulgur Wheat Flour Milling Subcategory § 406.41 Specialized...

40 CFR 406.51 - Specialized definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Specialized definitions. 406.51 Section 406.51 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Normal Rice Milling Subcategory § 406.51 Specialized definitions...

40 CFR 406.31 - Specialized definitions.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 28 2010-07-01 2010-07-01 true Specialized definitions. 406.31 Section 406.31 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) EFFLUENT GUIDELINES AND STANDARDS GRAIN MILLS POINT SOURCE CATEGORY Normal Wheat Flour Milling Subcategory § 406.31 Specialized...

Review of numerical special relativistic hydrodynamics

NARCIS (Netherlands)

D.E.A. van Odyck (Daniel)

2002-01-01

textabstractThis paper gives an overview of numerical methods for special relativistichydrodynamics (SRHD). First, a short summary of special relativity is given. Next, the SRHD equations are introduced. The exact solution for the SRHD Riemann problem is described. This solution is used in a Godunov

Job Design for Special Education Teachers

Science.gov (United States)

Major, Amanda E.

2012-01-01

Special education teachers, especially those that teach students with behavioral/emotional challenges, have high attrition rates stemming from stress, job dissatisfaction, and low motivation. The external factors in the school setting and job contribute to special education teachers' attrition and disengagement. A relationship between motivation…

Pathway elucidation and metabolic engineering of specialized plant metabolites

DEFF Research Database (Denmark)

Salomonsen, Bo

A worldwide need to liberate ourselves from unsustainable petrochemicals has led to numerous metabolic engineering projects, mostly carried out in microbial hosts. Using systems biology for predicting and altering the metabolism of microorganisms towards production of a desired metabolite......, these projects have increased revenues on fermentative production of several biochemicals. The use of systems biology is, however, not limited to microorganisms. Recent advances in biotechnology methods have provided a wealth of data within functional genomics, metabolomics, transcriptomics, proteomics...... and fluxomics for a considerable number of organisms. Unfortunately, transferring the wealth of data to valuable information for metabolic engineering purposes is a non-obvious task. This PhD thesis describes a palate of tools used in generation of cell factories for production of specialized plant metabolites...

Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions.

Science.gov (United States)

Kaji, Hirokazu; Camci-Unal, Gulden; Langer, Robert; Khademhosseini, Ali

2011-03-01

Inside the body, cells lie in direct contact or in close proximity to other cell types in a tightly controlled architecture that often regulates the resulting tissue function. Therefore, tissue engineering constructs that aim to reproduce the architecture and the geometry of tissues will benefit from methods of controlling cell-cell interactions with microscale resolution. We discuss the use of microfabrication technologies for generating patterned co-cultures. In addition, we categorize patterned co-culture systems by cell type and discuss the implications of regulating cell-cell interactions in the resulting biological function of the tissues. Patterned co-cultures are a useful tool for fabricating tissue engineered constructs and for studying cell-cell interactions in vitro, because they can be used to control the degree of homotypic and heterotypic cell-cell contact. In addition, this approach can be manipulated to elucidate important factors involved in cell-matrix interactions. Patterned co-culture strategies hold significant potential to develop biomimetic structures for tissue engineering. It is expected that they would create opportunities to develop artificial tissues in the future. This article is part of a Special Issue entitled Nanotechnologies - Emerging Applications in Biomedicine. 2010 Elsevier B.V. All rights reserved.

Special theory on chemical engineering

International Nuclear Information System (INIS)

1987-06-01

This book give a special description about chemical engineering. The contents of this book are special technique for isolation on introduction and separation by membrane, biochemistry engineering, process system engineering, energy engineering, environment engineering, a high molecular new material, election material and research on surface property of catalyst. It has appendixes on history of transition on Korean chemical engineering text contents and history of the activity of Korea chemical engineering institute.

Editorial: Special issue on education

OpenAIRE

Masal Ercan; Önder İsmail; Çalışkan Hüseyin; Beşoluk Şenol; Demirhan Eda

2017-01-01

This special issue consists of selected proceedings presented in ERPA International Congresses on Education 2017 which was held in Budapest / Hungary, 18-21 May 2017. Studies are related to educational sciences, science and mathematics education, social sciences education, health and sports science education, music and fine arts education, computer education and instructional technology, language education and management of education. There are eighty valuable studies in this special issue. I...

Smart Polymers with Special Wettability.

Science.gov (United States)

Chang, Baisong; Zhang, Bei; Sun, Taolei

2017-01-01

Surface wettability plays a key role in addressing issues ranging from basic life activities to our daily life, and thus being able to control it is an attractive goal. Learning from nature, both of its structure and function, brings us much inspiration in designing smart polymers to tackle this major challenge. Life functions particularly depend on biomolecular recognition-induced interfacial properties from the aqueous phase onto either "soft" cell and tissue or "hard" inorganic bone and tooth surfaces. The driving force is noncovalent weak interactions rather than strong covalent combinations. An overview is provided of the weak interactions that perform vital actions in mediating biological processes, which serve as a basis for elaborating multi-component polymers with special wettabilities. The role of smart polymers from molecular recognitions to macroscopic properties are highlighted. The rationale is that highly selective weak interactions are capable of creating a dynamic synergetic communication in the building components of polymers. Biomolecules could selectively induce conformational transitions of polymer chains, and then drive a switching of physicochemical properties, e.g., roughness, stiffness and compositions, which are an integrated embodiment of macroscopic surface wettabilities. © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Art Is Not Special

DEFF Research Database (Denmark)

Skov, Martin; Nadal, Marcos

2018-01-01

The assumption that human cognition requires exceptional explanations holds strong in some domains of behavioral and brain sciences. Scientific aesthetics in general, and neuroaesthetics in particular, abound with claims for art-specific cognitive or neural processes. This assumption fosters...... a conceptual structure disconnected from other fields and biases the sort of processes to be studied. More generally, assuming that art is special is to cling to the idea that some aspect of our species’ mental constitution makes us unique, special, and meaningful. This assumption continues to relegate...... scientific aesthetics to the periphery of science and hampers a naturalized view of the human mind....

Solar energy utilization by solar cells and superblack absorbers

Energy Technology Data Exchange (ETDEWEB)

Bonnet, D; Selders, M

1975-10-31

A review is presented of the physical principles responsible for the characteristics of solar cells, with particular reference to Si homojunction and CdS--Cu/sub 2/S thin film devices. Electric power generation from solar cells still appears uncompetitive economically except in special circumstances, but heating from solar energy using selective absorbers with low reemission is more promising.

An improved method for staining cell colonies in clonogenic assays

OpenAIRE

Guda, Kishore; Natale, Leanna; Markowitz, Sanford D.

2007-01-01

Clonogenic assay is a widely used experimental approach to test for the effects of drugs/genes on the growth and proliferative characteristics of cells in vitro. Accurate quantitation of treatment effects in clonogeneic assays depends on the ability to visualize and count cell colonies precisely. We report a novel method (referred as ETeB) for staining cell colonies grown on plastic and specially coated substrates like collagen. Using colon cancer cell lines grown on plastic and collagen, we ...

78 FR 24305 - Actions on Special Permit Applications

Science.gov (United States)

2013-04-24

... special permit Lincoln, NE. to authorize an alternative fire protection system. 11624-M Clean Harbors 49... Special Permit Applications AGENCY: Pipeline and Hazardous Materials Safety Administration (PHMSA), DOT. ACTION: Notice of actions on Special Permit Applications. SUMMARY: In accordance with the procedures...

Single-cell telomere-length quantification couples telomere length to meristem activity and stem cell development in Arabidopsis.

Science.gov (United States)

González-García, Mary-Paz; Pavelescu, Irina; Canela, Andrés; Sevillano, Xavier; Leehy, Katherine A; Nelson, Andrew D L; Ibañes, Marta; Shippen, Dorothy E; Blasco, Maria A; Caño-Delgado, Ana I

2015-05-12

Telomeres are specialized nucleoprotein caps that protect chromosome ends assuring cell division. Single-cell telomere quantification in animals established a critical role for telomerase in stem cells, yet, in plants, telomere-length quantification has been reported only at the organ level. Here, a quantitative analysis of telomere length of single cells in Arabidopsis root apex uncovered a heterogeneous telomere-length distribution of different cell lineages showing the longest telomeres at the stem cells. The defects in meristem and stem cell renewal observed in tert mutants demonstrate that telomere lengthening by TERT sets a replicative limit in the root meristem. Conversely, the long telomeres of the columella cells and the premature stem cell differentiation plt1,2 mutants suggest that differentiation can prevent telomere erosion. Overall, our results indicate that telomere dynamics are coupled to meristem activity and continuous growth, disclosing a critical association between telomere length, stem cell function, and the extended lifespan of plants. Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.

34 CFR 300.39 - Special education.

Science.gov (United States)

2010-07-01

... 34 Education 2 2010-07-01 2010-07-01 false Special education. 300.39 Section 300.39 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF SPECIAL EDUCATION AND REHABILITATIVE SERVICES, DEPARTMENT OF EDUCATION ASSISTANCE TO STATES FOR THE EDUCATION OF CHILDREN WITH...

On special relativity with cosmological constant

International Nuclear Information System (INIS)

Guo Hanying; Huang Chaoguang; Xu Zhan; Zhou Bin

2004-01-01

Based on the principle of relativity and the postulate of invariant speed and length, we propose the theory of special relativity with cosmological constant SRc,R, in which the cosmological constant is linked with the invariant length. Its relation with the doubly special relativity is briefly mentioned

25 CFR 67.15 - Special instructions.

Science.gov (United States)

2010-04-01

... Area Director, the Assistant Secretary may issue special instructions not inconsistent with the... 25 Indians 1 2010-04-01 2010-04-01 false Special instructions. 67.15 Section 67.15 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT PREPARATION OF A ROLL OF INDEPENDENT...

Danish Politicians' Views on Special Operations

DEFF Research Database (Denmark)

Jensen, Lars Henrik Ehrensvärd

2017-01-01

and willingness of Danish politicians regarding the use of special operations. This may indicate a difference between the potential opportunities for employing special operations and what the politicians believe these to be and are willing to promote or allow. Conclusion: Pending further analysis of the data...

Selected Topics in International Special Education.

Science.gov (United States)

Kelly, Nancy

2002-01-01

This article provides information on special education topics on the international front. Information is presented on projects that evaluated early intervention programs, a life-centered career education program in the Philippines, a Peruvian vocational program for individuals with severe disabilities, and special classes for children with…

28 CFR 42.714 - Special benefits.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Special benefits. 42.714 Section 42.714 Judicial Administration DEPARTMENT OF JUSTICE NONDISCRIMINATION; EQUAL EMPLOYMENT OPPORTUNITY; POLICIES AND... benefits. If a recipient operating a program or activity provides special benefits to the elderly or to...

Mechanisms for Teaching Typewriting to Special Students.

Science.gov (United States)

Rosetti, Mary Ellen

1979-01-01

Gives examples of specialized typewriting instructional methods for students with disabilities, involving modifications to typewriters, using special keyboards, and adding sensory devices for different impairments. (MF)

Physical View on the Interactions Between Cancer Cells and the Endothelial Cell Lining During Cancer Cell Transmigration and Invasion

Science.gov (United States)

Mierke, Claudia T.

There exist many reviews on the biological and biochemical interactions of cancer cells and endothelial cells during the transmigration and tissue invasion of cancer cells. For the malignant progression of cancer, the ability to metastasize is a prerequisite. In particular, this means that certain cancer cells possess the property to migrate through the endothelial lining into blood or lymph vessels, and are possibly able to transmigrate through the endothelial lining into the connective tissue and follow up their invasion path in the targeted tissue. On the molecular and biochemical level the transmigration and invasion steps are well-defined, but these signal transduction pathways are not yet clear and less understood in regards to the biophysical aspects of these processes. To functionally characterize the malignant transformation of neoplasms and subsequently reveal the underlying pathway(s) and cellular properties, which help cancer cells to facilitate cancer progression, the biomechanical properties of cancer cells and their microenvironment come into focus in the physics-of-cancer driven view on the metastasis process of cancers. Hallmarks for cancer progression have been proposed, but they still lack the inclusion of specific biomechanical properties of cancer cells and interacting surrounding endothelial cells of blood or lymph vessels. As a cancer cell is embedded in a special environment, the mechanical properties of the extracellular matrix also cannot be neglected. Therefore, in this review it is proposed that a novel hallmark of cancer that is still elusive in classical tumor biological reviews should be included, dealing with the aspect of physics in cancer disease such as the natural selection of an aggressive (highly invasive) subtype of cancer cells displaying a certain adhesion or chemokine receptor on their cell surface. Today, the physical aspects can be analyzed by using state-of-the-art biophysical methods. Thus, this review will present

Medical speciality choice: does personality matter?

LENUS (Irish Health Repository)

Lydon, S

2015-03-01

There has been increasing interest in the personalities of doctors. This study examined whether personality differed based upon gender, level of training or medical speciality among 200 physicians and 134 medical students. Post-internship doctors scored significantly higher on conscientiousness (p = .001) than those pursuing basic medical training. Among those pursuing basic medical training, females scored significantly higher than males on agreeableness (p < .001) and conscientiousness (p = .001). Among post-internship respondents, females scored significantly higher on agreeableness (p = .004). There were no personality differences between post-internship doctors working in different specialities. However, among those pursuing basic medical training, those interested in person-focused medical specialities scored significantly higher on extraversion (p < .001), conscientiousness (p = .001), and lower on neuroticism (p = .01) than those who had no strong preference. These results suggest that there is no unique personality profile associated with medical practice, or medical speciality. Instead, it appears that medical school may shape personality.

Homogenization of Mammalian Cells.

Science.gov (United States)

de Araújo, Mariana E G; Lamberti, Giorgia; Huber, Lukas A

2015-11-02

Homogenization is the name given to the methodological steps necessary for releasing organelles and other cellular constituents as a free suspension of intact individual components. Most homogenization procedures used for mammalian cells (e.g., cavitation pump and Dounce homogenizer) rely on mechanical force to break the plasma membrane and may be supplemented with osmotic or temperature alterations to facilitate membrane disruption. In this protocol, we describe a syringe-based homogenization method that does not require specialized equipment, is easy to handle, and gives reproducible results. The method may be adapted for cells that require hypotonic shock before homogenization. We routinely use it as part of our workflow to isolate endocytic organelles from mammalian cells. © 2015 Cold Spring Harbor Laboratory Press.

48 CFR 1336.270 - Special requirements for ship construction

Science.gov (United States)

2010-10-01

... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Special requirements for ship construction 1336.270 Section 1336.270 Federal Acquisition Regulations System DEPARTMENT OF COMMERCE SPECIAL CATEGORIES OF CONTRACTING CONSTRUCTION AND ARCHITECT-ENGINEER CONTRACTS Special Aspects of Contracting for Construction 1336.270 Special...

A Comparative Study of Administrator and Special Education Teacher Perceptions of Special Education Teacher Attrition and Retention

Science.gov (United States)

Sheldrake, Danielle Angelina

2013-01-01

This mixed methods study identifies perceived causes of and solutions to the attrition of special education teachers. Researchers have documented that special education teaching positions encounter higher attrition rates than their general education peers (Katsiyannis, Zhang, & Conroy in Olivarez & Arnold, 2006; Mitchell & Arnold,…

Office of Special Services Annual Report, FY 1999.

Science.gov (United States)

Front Range Community Coll., Westminster, CO.

This report lists support services provided by the Westminster Campus Special Services Department to the Westminster, Brighton, Longmont, and North Boulder Campuses. The Special Services Department provides disability services, including interpreting for the deaf, tutoring, gender equity support, and special populations transition support.…

Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes.

Science.gov (United States)

Wheaton, Joshua D; Yeh, Chen-Hao; Ciofani, Maria

2017-12-15

Regulatory T cells (Tregs) adopt specialized phenotypes defined by coexpression of lineage-defining transcription factors, such as RORγt, Bcl-6, or PPARγ, alongside Foxp3. These Treg subsets have unique tissue distributions and diverse roles in maintaining organismal homeostasis. However, despite extensive functional characterization, the factors driving Treg specialization are largely unknown. In this article, we show that c-Maf is a critical transcription factor regulating this process in mice, essential for generation of both RORγt + Tregs and T follicular regulatory cells, but not for adipose-resident Tregs. c-Maf appears to function primarily in Treg specialization, because IL-10 production, expression of other effector molecules, and general immune homeostasis are not c-Maf dependent. As in other T cells, c-Maf is induced in Tregs by IL-6 and TGF-β, suggesting that a combination of inflammatory and tolerogenic signals promote c-Maf expression. Therefore, c-Maf is a novel regulator of Treg specialization, which may integrate disparate signals to facilitate environmental adaptation. Copyright © 2017 by The American Association of Immunologists, Inc.

The Innovative Design of Lucas Cell for Radon Gas Measurement

International Nuclear Information System (INIS)

Wanabongse, Paitoon; Rattanabussayaporn, Sakon; Sriya, Maitree; Sola, Banthom

2007-08-01

Full text: Lucas scintillation cell has been widely used for radon gas measurement. They are commercially available but usually with a rather high price, therefore, four cells were developed and built in house. The invented radon gas detector has a special feature; the circumference of the upper part of the cylindrical detector is larger than the lower part. The purpose of this is to allow the light sensing device coupled at the lower end can better detect the phosphorescence light occurred inside. The result is that the invented detector yields higher detection efficiency. This special feature also allows us to increase the volume of the detector which results in higher detection sensitivity

25 CFR 61.15 - Special instructions.

Science.gov (United States)

2010-04-01

... Secretary may issue special instructions not inconsistent with the regulations in this part 61. ... 25 Indians 1 2010-04-01 2010-04-01 false Special instructions. 61.15 Section 61.15 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR TRIBAL GOVERNMENT PREPARATION OF ROLLS OF INDIANS § 61...

7 CFR 29.3547 - Special factor.

Science.gov (United States)

2010-01-01

... 7 Agriculture 2 2010-01-01 2010-01-01 false Special factor. 29.3547 Section 29.3547 Agriculture Regulations of the Department of Agriculture AGRICULTURAL MARKETING SERVICE (Standards, Inspections, Marketing... Type 95) § 29.3547 Special factor. A symbol or term authorized to designate a peculiar side or...

34 CFR 674.51 - Special definitions.

Science.gov (United States)

2010-07-01

... from ages 3 through 21, inclusive, who requires special education and related services because he or... 34 Education 3 2010-07-01 2010-07-01 false Special definitions. 674.51 Section 674.51 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF POSTSECONDARY EDUCATION...

Science and Sanity in Special Education.

Science.gov (United States)

Dammann, James E.; Vaughn, Sharon

2001-01-01

This article describes the usefulness of a scientific approach to improving knowledge and practice in special education. Of four approaches to knowledge (superstition, folklore, craft, and science), craft and science are supported and implications for special education drawn including the need to bridge the gulf between research knowledge and…

31 CFR 595.311 - Specially designated terrorist.

Science.gov (United States)

2010-07-01

...) OFFICE OF FOREIGN ASSETS CONTROL, DEPARTMENT OF THE TREASURY TERRORISM SANCTIONS REGULATIONS General Definitions § 595.311 Specially designated terrorist. (a) The term specially designated terrorist means: (1...

Xenotransplantation — A special case of One Health

Directory of Open Access Journals (Sweden)

Joachim Denner

2017-06-01

Full Text Available The chronic shortage of human transplants to treat tissue and organ failure has led to the development of xenotransplantation, the transplantation of cells, tissues and organs from another species to human recipients. For a number of reasons, pigs are best suited as donor animals. Successful, routine xenotransplantation would have an enormous impact on the health of the human population, including the young, who sometimes require a replacement organ or islet cells, but especially the elderly, who more often suffer the consequences of organ failure. The first form of xenotransplantation applied to humans is the use of pig islet cells to treat insulin-dependent diabetes, a procedure that will have a significant economic impact. However, although xenotransplantation using pig cells, tissues and organs may save and prolong the lives of patients, it may also be associated with the transmission of porcine microorganisms to the recipient, eventually resulting in emerging infectious diseases. For this reason, the health of both the donor animals and the human recipients represents a special and sensitive case of the One Health concept. Basic research leading to strategies how to prevent transmission of porcine microorganisms by selection of virus-free animals, treatment of donor pigs by antiviral drugs, vaccines, colostrum deprivation, early weaning, Caesarean delivery, embryo transfer and/or gene editing should be undertaken to supply an increasing number of potential recipients with urgently required transplants. The methods developed for the detection and elimination of porcine microorganisms in the context of xenotransplantation will also contribute to an improvement in the health of pig populations in general and an increase in the quality of meat products. At present, there is evidence for transmission of porcine viruses to humans eating pork and having contact with pigs, however the impact of these viruses on public health is still unknown.

Cookbooks and Good Eating: Cookbooks for Special Populations.

Science.gov (United States)

Ensign, Arselia S., Ed.

1990-01-01

The brochure briefly describes approximately 50 cookbooks and related materials appropriate for use with special populations. For most entries, title, author, source, price, and a brief description are provided. Entries include general cookbooks, large print and Braille cookbooks, cookbooks for special diets, cookbooks for special conditions,…

Early Specialization in Youth Sport: A Biomechanical Perspective

Science.gov (United States)

Mattson, Jeffrey M.; Richards, Jim

2010-01-01

This article examines, from a biomechanical perspective, three issues related to early specialization: overuse injuries, the developmental aspects, and the performance aspects. It concludes that "there is no evidence that early specialization causes overuse injuries or hinders growth and maturation." At the same time, early specialization has…

Special Education Teachers' Nature of Science Instructional Experiences

Science.gov (United States)

Mulvey, Bridget K.; Chiu, Jennifer L.; Ghosh, Rajlakshmi; Bell, Randy L.

2016-01-01

Special education teachers provide critical science instruction to students. However, little research investigates special education teacher beliefs and practices around science in general or the nature of science and inquiry in particular. This investigation is a cross-case analysis of four elementary special education teachers' initial…

Special Education Compliance: Program Review Standards and Indicators.

Science.gov (United States)

Missouri State Dept. of Elementary and Secondary Education, Jefferson City. Div. of Special Education.

This manual contains special education standards and indicators for educating children with disabilities in Missouri. It is divided into four main sections. Section 1 contains special education compliance standards based upon the federal Office of Special Education Programs Continuous Improvement Monitoring Program clusters and indicators. The…

24 CFR 1003.203 - Special economic development activities.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 4 2010-04-01 2010-04-01 false Special economic development... Eligible Activities § 1003.203 Special economic development activities. A grantee may use ICDBG funds for special economic development activities in addition to other activities authorized in this subpart which...

24 CFR 570.203 - Special economic development activities.

Science.gov (United States)

2010-04-01

... 24 Housing and Urban Development 3 2010-04-01 2010-04-01 false Special economic development... § 570.203 Special economic development activities. A recipient may use CDBG funds for special economic... part of an economic development project. Guidelines for selecting activities to assist under this...

Bacillus subtilis Swarmer Cells Lead the Swarm, Multiply, and Generate a Trail of Quiescent Descendants

Directory of Open Access Journals (Sweden)

Lina Hamouche

2017-02-01

Full Text Available Bacteria adopt social behavior to expand into new territory, led by specialized swarmers, before forming a biofilm. Such mass migration of Bacillus subtilis on a synthetic medium produces hyperbranching dendrites that transiently (equivalent to 4 to 5 generations of growth maintain a cellular monolayer over long distances, greatly facilitating single-cell gene expression analysis. Paradoxically, while cells in the dendrites (nonswarmers might be expected to grow exponentially, the rate of swarm expansion is constant, suggesting that some cells are not multiplying. Little attention has been paid to which cells in a swarm are actually multiplying and contributing to the overall biomass. Here, we show in situ that DNA replication, protein translation and peptidoglycan synthesis are primarily restricted to the swarmer cells at dendrite tips. Thus, these specialized cells not only lead the population forward but are apparently the source of all cells in the stems of early dendrites. We developed a simple mathematical model that supports this conclusion.

Polycyclic aromatic hydrocarbons stimulate cell proliferation of human breast cancer MCF-7 cells

Czech Academy of Sciences Publication Activity Database

Vondráček, Jan; Plíšková, M.; Vojtěšek, B.; Kozubík, Alois; Machala, M.

2003-01-01

Roč. 270, Suppl. 1 (2003), s. 127 ISSN 0014-2956. [FEBS Special Meeting 2003 on Signal Transduction. 03.07.2003-08.07.2003, Brussels] R&D Projects: GA ČR GP525/01/D076; GA ČR GA525/03/1527 Institutional research plan: CEZ:AV0Z5004920 Keywords : cell proliferation * estrogen receptor * p53 Subject RIV: BO - Biophysics

Isolation and Culture of Postnatal Stem Cells from Deciduous Teeth

OpenAIRE

Olávez, Daniela; Facultad de Odontología Universidad de Los Andes; Salmen, Siham; Instituto de Inmunología Clínica, Universidad de Los Andes.; Padrón, Karla; Facultad de Odontología. Univerisdad de Los Andes.; Lobo, Carmine; Facultad de Odontología. Univerisdad de Los Andes.; Díaz, Nancy; Facultad de Odontología, Universidad de Los Andes.; Berrueta, Lisbeth; Doctora en Inmunología por Instituto Venezolano de Investigaciones Científicas (IVIC). Instituto de Inmunología Clínica, Facultad de Medicina, Universidad de Los Andes, Venezuela.; Solorzanio, Eduvigis; Facultad de Odontología, Universidad de Los Andes.

2014-01-01

Background: Currently, degenerative diseases represent a public health problem; therefore, the development and implementation of strategies to fully or partially recover of damaged tissues has a special interest in the biomedical field. Therapeutic strategies based on mesenchymal stem cells transplantation from dental pulp have been proposed as an alternative. Purpose: To develop a mesenchymal stem cells culture isolated from dental pulp of deciduous teeth. Methods: The mesenchymal stem cells...

Illinois Directors' of Special Education Perceptions of Their Leadership Styles and Importance of the Illinois Standards for Director of Special Education

Science.gov (United States)

Gunnell, James W.

2013-01-01

This research examined the relationship between Illinois Directors, of special education leadership styles and the importance of the Illinois mandated standards for Director of special education. It extends the current research in educational leadership by specifically exploring the relationship between the importance of special education…

The Development of Adult Innate Lymphoid Cells

Science.gov (United States)

Yang, Qi; Bhandoola, Avinash

2016-01-01

Innate lymphoid cells (ILC) are a specialized family of effector lymphocytes that transcriptionally and functionally mirror effector subsets of T cells, but differ from T cells in that they lack clonally-distributed adaptive antigen receptors. Our understanding of this family of lymphocytes is still in its infancy. In this review, we summarize current understanding and discuss recent insights into the cellular and molecular events that occur during early ILC development in adult mice. We discuss how these events overlap and diverge with the early development of adaptive T cells, and how they may influence the molecular and functional properties of mature ILC. PMID:26871595

75 FR 44881 - Special Conditions: Garmin International G1000 and GFC700 System Installation in the Cessna Model...

Science.gov (United States)

2010-07-30

... delivery of the affected aircraft. In addition, the substance of these special conditions has been subject... flammable. This material can serve as a source of fuel for an external fire in the event of a cell container... sections of Sec. 23.1353 that are applicable to batteries of any type. (2) Inclusion of the flammable fluid...

Pengelolaan Perpustakaan Khusus = Special Library Management

OpenAIRE

Surachman, Arif

2005-01-01

This article describes every aspects needed to manage special library and complete with its example and explanation. The author uses the American corner UGM and PSKP UGM (Pusat Studi Keamanan dan Perdamaian = Security and Peace Studies Center) Library as a case study of the implementation special library management in UGM university.

9 CFR 93.916 - Special provisions.

Science.gov (United States)

2010-01-01

... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Special provisions. 93.916 Section 93... § 93.916 Special provisions. (a) Slaughter. Live VHS-regulated fish from VHS-regulated regions may be... establishment discharges its waste water to a municipal sewage system that includes waste water disinfection...

Early Sport Specialization: A Psychological Perspective

Science.gov (United States)

Gould, Daniel

2010-01-01

Specializing too early in life can lead to emotional stress, loss of motivation, and burnout, but the research is inadequate to resolve the question of whether early specialization or diversification is more beneficial from a psychological perspective. Nevertheless, some best practices are recommended based on the known benefits and detriments.…

Special Classes for Gifted Students? Absolutely!

Science.gov (United States)

Burton-Szabo, Sally

1996-01-01

This article makes a case for special classes for gifted students and answers objections to special classes raised by the middle school movement and the cooperative learning movement. A sample "Celebration of Me" unit taught to gifted seventh graders which involved poetry, literature, personal development, art, music, and physical fitness is…

Examining Secondary Special Education Teachers' Literacy Instructional Practices

Science.gov (United States)

Leko, Melinda M.; Handy, Tamara; Roberts, Carly A.

2017-01-01

This study presents findings from a survey of secondary special education teachers who teach reading. Respondents were 577 special education teachers from a large Midwestern state who completed an online or mail survey. Results based on quantitative and qualitative analyses indicate predominant foci of secondary special education teachers' reading…

SELF EVALUATION OF COMPETENCES OF THE SPECIAL EDUCATORS AND REHABILITATORS IN THE SPECIAL INSTITUTION

Directory of Open Access Journals (Sweden)

Natasha M. CHICHEVSKA-JOVANOVA

2009-06-01

Full Text Available The primary goal of this empirical research was to determinate how much has current education helped special educators and rehabilitators in forming separate competences, and if those competencies correspond to the desired ones, which are necessary for the work of the special educators and rehabilitators.The results have shown that one type of the competences in the program had been neglected up to now. Therefore, it is necessary for this fact to be taken into consideration when designing the new study programs.

Evidence of specialized tissue in human interatrial septum: histological, immunohistochemical and ultrastructural findings.

Science.gov (United States)

Mitrofanova, Lubov B; Gorshkov, Andrey N; Lebedev, Dmitry S; Mikhaylov, Evgeny N

2014-01-01

There is a paucity of information on structural organization of muscular bundles in the interatrial septum (IAS). The aim was to investigate histologic and ultrastructural organization of muscular bundles in human IAS, including fossa ovalis (FO) and flap valve. Macroscopic and light microscopy evaluations of IAS were performed from postmortem studies of 40 patients. Twenty three IAS specimens underwent serial transverse sectioning, and 17--longitudinal sectioning. The transverse sections from 10 patients were immunolabeled for HCN4, Caveolin3 and Connexin43. IAS specimens from 6 other patients underwent electron microscopy. In all IAS specimens sections the FO, its rims and the flap valve had muscle fibers consisting of working cardiac myocytes. Besides the typical cardiomyocytes there were unusual cells: tortuous and horseshoe-shaped intertangled myocytes, small and large rounded myocytes with pale cytoplasm. The cells were aggregated in a definite structure in 38 (95%) cases, which was surrounded by fibro-fatty tissue. The height of the structure on transverse sections positively correlated with age (P = 0.03) and AF history (P = 0.045). Immunohistochemistry showed positive staining of the cells for HCN4 and Caveolin3. Electron microscopy identified cells with characteristics similar to electrical conduction cells. Specialized conduction cells in human IAS have been identified, specifically in the FO and its flap valve. The cells are aggregated in a structure, which is surrounded by fibrous and fatty tissue. Further investigations are warranted to explore electrophysiological characteristics of this structure.

Evidence of specialized tissue in human interatrial septum: histological, immunohistochemical and ultrastructural findings.

Directory of Open Access Journals (Sweden)

Lubov B Mitrofanova

Full Text Available There is a paucity of information on structural organization of muscular bundles in the interatrial septum (IAS. The aim was to investigate histologic and ultrastructural organization of muscular bundles in human IAS, including fossa ovalis (FO and flap valve.Macroscopic and light microscopy evaluations of IAS were performed from postmortem studies of 40 patients. Twenty three IAS specimens underwent serial transverse sectioning, and 17--longitudinal sectioning. The transverse sections from 10 patients were immunolabeled for HCN4, Caveolin3 and Connexin43. IAS specimens from 6 other patients underwent electron microscopy.In all IAS specimens sections the FO, its rims and the flap valve had muscle fibers consisting of working cardiac myocytes. Besides the typical cardiomyocytes there were unusual cells: tortuous and horseshoe-shaped intertangled myocytes, small and large rounded myocytes with pale cytoplasm. The cells were aggregated in a definite structure in 38 (95% cases, which was surrounded by fibro-fatty tissue. The height of the structure on transverse sections positively correlated with age (P = 0.03 and AF history (P = 0.045. Immunohistochemistry showed positive staining of the cells for HCN4 and Caveolin3. Electron microscopy identified cells with characteristics similar to electrical conduction cells.Specialized conduction cells in human IAS have been identified, specifically in the FO and its flap valve. The cells are aggregated in a structure, which is surrounded by fibrous and fatty tissue. Further investigations are warranted to explore electrophysiological characteristics of this structure.

Terminology: A necessary tool for the Specialized Translator

Directory of Open Access Journals (Sweden)

Aura E. Navarro

2016-03-01

Full Text Available Language disciplines, including Terminology and Specialized Translation, have made great strides after the second half of the twentieth century. This development, related to technological growth and international communication that occurred during this period, has resulted in a considerable increase of concepts. Thus, experts have become more and more aware of the importance of naming these new concepts. Specialized translators were among the first language professionals to recognize the need of mastering the terminology of specialized fields in order to perform their duties well (Antia et coll., 2005. In this work, we study the very close relationship between Terminology and Specialized Translation. We also study the theoretical and practical knowledge of Terminology that a specialized translator should have.

Specialization, Outsourcing and Wages

DEFF Research Database (Denmark)

Munch, Jakob Roland; Rose Skaksen, Jan

2005-01-01

This paper studies the impact of outsourcing on individual wages. In contrast to the standard approach in the literature, we focus on domestic outsourcing as well as foreign outsourcing. By using a simple theoretical model, we argue that, if outsourcing is associated with specialization gains...... arising from an increase in the extent of the market for intermediate goods, domestic outsourcing tends to increase wages for both unskilled and skilled labor. We use a panel data set of workers in Danish manufacturing industries to show that domestic and foreign outsurcing affect wages as predicted...... by the theory.Keywords: Outsourcing, Comparative advantage, Specialization, Wages.JEL Classification: F16, J31, C23....

Of Microenvironments and Mammary Stem Cells

Energy Technology Data Exchange (ETDEWEB)

LaBarge, Mark A; Petersen, Ole W; Bissell, Mina J

2007-06-01

In most adult tissues there reside pools of stem and progenitor cells inside specialized microenvironments referred to as niches. The niche protects the stem cells from inappropriate expansion and directs their critical functions. Thus guided, stem cells are able to maintain tissue homeostasis throughout the ebb and flow of metabolic and physical demands encountered over a lifetime. Indeed, a pool of stem cells maintains mammary gland structure throughout development, and responds to the physiological demands associated with pregnancy. This review discusses how stem cells were identified in both human and mouse mammary glands; each requiring different techniques that were determined by differing biological needs and ethical constraints. These studies together create a robust portrait of mammary gland biology and identify the location of the stem cell niche, elucidate a developmental hierarchy, and suggest how the niche might be manipulated for therapeutic benefit.

Memory NK cells: why do they reside in the liver?

OpenAIRE

Jiang, Xiaojun; Chen, Yonglin; Peng, Hui; Tian, Zhigang

2013-01-01

Immune memory is the hallmark of adaptive immunity. However, recent studies have shown that natural killer (NK) cells, key components of the innate immune system, also mediate memory responses in mice and humans. Strikingly, memory NK cells were liver-resident in some models, raising the question as to whether the liver is a special organ for the acquisition of NK cell memory. Here, we review the characteristics of NK cell memory by summarizing recent progress and discuss how the liver may ge...

Cell wall assembly and intracellular trafficking in plant cells are directly affected by changes in the magnitude of gravitational acceleration.

Directory of Open Access Journals (Sweden)

Youssef Chebli

Full Text Available Plants are able to sense the magnitude and direction of gravity. This capacity is thought to reside in selected cell types within the plant body that are equipped with specialized organelles called statoliths. However, most plant cells do not possess statoliths, yet they respond to changes in gravitational acceleration. To understand the effect of gravity on the metabolism and cellular functioning of non-specialized plant cells, we investigated a rapidly growing plant cell devoid of known statoliths and without gravitropic behavior, the pollen tube. The effects of hyper-gravity and omnidirectional exposure to gravity on intracellular trafficking and on cell wall assembly were assessed in Camellia pollen tubes, a model system with highly reproducible growth behavior in vitro. Using an epi-fluorescence microscope mounted on the Large Diameter Centrifuge at the European Space Agency, we were able to demonstrate that vesicular trafficking is reduced under hyper-gravity conditions. Immuno-cytochemistry confirmed that both in hyper and omnidirectional gravity conditions, the characteristic spatial profiles of cellulose and callose distribution in the pollen tube wall were altered, in accordance with a dose-dependent effect on pollen tube diameter. Our findings suggest that in response to gravity induced stress, the pollen tube responds by modifying cell wall assembly to compensate for the altered mechanical load. The effect was reversible within few minutes demonstrating that the pollen tube is able to quickly adapt to changing stress conditions.

U.S. Special Operations Command Training and Education Program

National Research Council Canada - National Science Library

Gimble, Thomas

1996-01-01

.... Special Operations Command (USCINCSOC), to train assigned forces to meet special operations mission taskings and to ensure interoperability with conventional forces and other special operations forces (SOF...

39 CFR 122.2 - Stand-alone special services.

Science.gov (United States)

2010-07-01

... 39 Postal Service 1 2010-07-01 2010-07-01 false Stand-alone special services. 122.2 Section 122.2 Postal Service UNITED STATES POSTAL SERVICE POST OFFICE SERVICES [DOMESTIC MAIL] SERVICE STANDARDS FOR MARKET-DOMINANT SPECIAL SERVICES PRODUCTS § 122.2 Stand-alone special services. (a) The service standard...

38 CFR 61.44 - Awarding special needs grants.

Science.gov (United States)

2010-07-01

... 38 Pensions, Bonuses, and Veterans' Relief 2 2010-07-01 2010-07-01 false Awarding special needs... (CONTINUED) VA HOMELESS PROVIDERS GRANT AND PER DIEM PROGRAM § 61.44 Awarding special needs grants. (a... applicable, will be conditionally selected to receive a special needs grant in accordance with their ranked...

Innovation on Smart Grids and energy storage. IA Special; Innovation on Smart Grids and energy storage. IA Special

Energy Technology Data Exchange (ETDEWEB)

NONE

2012-11-15

In this special edition of the Innovation Network Attache a large number of short articles on aspects of ICT aspects of intellligent energy networks, the security and integrity of the use and control of those networks, and energy storage. In this special an overview is given of the most important developments in Israel, Russian Federation, Brazil, Netherlands, France, Germany, Singapore, Japan, Taiwan, China, South Korea, India, United States and Canada [Dutch] In deze special van het Innovation Attache Netwerk een groot aantal korte artikelen over de ICT aspecten van intellligente energie netten, de veiligheid en integriteit van het gebruik en sturing ervan, en energie opslag. In de special een overzicht van in het oog springende ontwikkelingen in de landen Israel, Rusland, Brazilie, Nederland, Frankrijk, Duitsland, Singapore, Japan, Taiwan, China, Zuid-Korea, India, Verenigde Staten en Canada.

Lipid rafts and B cell signaling.

Science.gov (United States)

Gupta, Neetu; DeFranco, Anthony L

2007-10-01

B cells comprise an essential component of the humoral immune system. They are equipped with the unique ability to synthesize and secrete pathogen-neutralizing antibodies, and share with professional antigen presenting cells the ability to internalize foreign antigens, and process them for presentation to helper T cells. Recent evidence indicates that specialized cholesterol- and glycosphingolipid-rich microdomains in the plasma membrane commonly referred to as lipid rafts, serve to compartmentalize key signaling molecules during the different stages of B cell activation including B cell antigen receptor (BCR)-initiated signal transduction, endocytosis of BCR-antigen complexes, loading of antigenic peptides onto MHC class II molecules, MHC-II associated antigen presentation to helper T cells, and receipt of helper signals via the CD40 receptor. Here we review the recent literature arguing for a role of lipid rafts in the spatial organization of B cell function.

Fluent Reading in Special Primary Education

Science.gov (United States)

Houtveen, Anthonia A. M.; van de Grift, Wim J. C. M.; Brokamp, Saskia K.

2014-01-01

The learning gains in reading of students in 57 classrooms in special primary education doubled as a result of implementing the Reading Impulse in Special Education (RISE) programme. Raising the scheduled reading time with 1.5 hr in all classrooms and implementing standards-based teaching characterised by "monitoring of pupil progress",…

On computing special functions in marine engineering

Science.gov (United States)

Constantinescu, E.; Bogdan, M.

2015-11-01

Important modeling applications in marine engineering conduct us to a special class of solutions for difficult differential equations with variable coefficients. In order to be able to solve and implement such models (in wave theory, in acoustics, in hydrodynamics, in electromagnetic waves, but also in many other engineering fields), it is necessary to compute so called special functions: Bessel functions, modified Bessel functions, spherical Bessel functions, Hankel functions. The aim of this paper is to develop numerical solutions in Matlab for the above mentioned special functions. Taking into account the main properties for Bessel and modified Bessel functions, we shortly present analytically solutions (where possible) in the form of series. Especially it is studied the behavior of these special functions using Matlab facilities: numerical solutions and plotting. Finally, it will be compared the behavior of the special functions and point out other directions for investigating properties of Bessel and spherical Bessel functions. The asymptotic forms of Bessel functions and modified Bessel functions allow determination of important properties of these functions. The modified Bessel functions tend to look more like decaying and growing exponentials.

Special event planning for the emergency manager.

Science.gov (United States)

Gaynor, Peter T

2009-11-01

In the domain of emergency management and homeland security there is a lack of a formal planning process at the local level when it comes to special event planning. The unique nature of special event planning demands an understanding of the planning process for both traditional and non-traditional planning partners. This understanding will make certain that local governments apply due diligence when planning for the safety of the public. This paper offers a practical roadmap for planning at the local level. It will address those 'special events' that are beyond routine local events but not of a sufficient scale to be granted National Special Security Event status. Due to the infrequency of 'special events' in most communities, it is imperative that deliberate planning takes place. Upon conclusion, the reader will be able to construct a planning process tailored to the needs of their community, guide both traditional and non-traditional planning partners through the planning process, determine priorities, explore alternatives, plan for contingencies, conduct a confirmation brief, facilitate operations and assemble an after-action report and improvement plan.

Live cell imaging techniques to study T cell trafficking across the blood-brain barrier in vitro and in vivo

Directory of Open Access Journals (Sweden)

Coisne Caroline

2013-01-01

Full Text Available Abstract Background The central nervous system (CNS is an immunologically privileged site to which access for circulating immune cells is tightly controlled by the endothelial blood–brain barrier (BBB located in CNS microvessels. Under physiological conditions immune cell migration across the BBB is low. However, in neuroinflammatory diseases such as multiple sclerosis, many immune cells can cross the BBB and cause neurological symptoms. Extravasation of circulating immune cells is a multi-step process that is regulated by the sequential interaction of different adhesion and signaling molecules on the immune cells and on the endothelium. The specialized barrier characteristics of the BBB, therefore, imply the existence of unique mechanisms for immune cell migration across the BBB. Methods and design An in vitro mouse BBB model maintaining physiological barrier characteristics in a flow chamber and combined with high magnification live cell imaging, has been established. This model enables the molecular mechanisms involved in the multi-step extravasation of T cells across the in vitro BBB, to be defined with high-throughput analyses. Subsequently these mechanisms have been verified in vivo using a limited number of experimental animals and a spinal cord window surgical technique. The window enables live observation of the dynamic interaction between T cells and spinal cord microvessels under physiological and pathological conditions using real time epifluorescence intravital imaging. These in vitro and in vivo live cell imaging methods have shown that the BBB endothelium possesses unique and specialized mechanisms involved in the multi-step T cell migration across this endothelial barrier under physiological flow. The initial T cell interaction with the endothelium is either mediated by T cell capture or by T cell rolling. Arrest follows, and then T cells polarize and especially CD4+ T cells crawl over long distances against the direction of

[Germ cell membrane lipids in spermatogenesis].

Science.gov (United States)

Wang, Ting; Shi, Xiao; Quan, Song

2016-05-01

Spermatogenesis is a complex developmental process in which a diploid progenitor germ cell transforms into highly specialized spermatozoa. During spermatogenesis, membrane remodeling takes place, and cell membrane permeability and liquidity undergo phase-specific changes, which are all associated with the alteration of membrane lipids. Lipids are important components of the germ cell membrane, whose volume and ratio fluctuate in different phases of spermatogenesis. Abnormal lipid metabolism can cause spermatogenic dysfunction and consequently male infertility. Germ cell membrane lipids are mainly composed of cholesterol, phospholipids and glycolipids, which play critical roles in cell adhesion and signal transduction during spermatogenesis. An insight into the correlation of membrane lipids with spermatogenesis helps us to better understand the mechanisms of spermatogenesis and provide new approaches to the diagnosis and treatment of male infertility.

Translating Research into Clinical Scale Manufacturing of Mesenchymal Stromal Cells

Directory of Open Access Journals (Sweden)

Karen Bieback

2010-01-01

Full Text Available It sounds simple to obtain sufficient numbers of cells derived from fetal or adult human tissues, isolate and/or expand the stem cells, and then transplant an appropriate number of these cells into the patient at the correct location. However, translating basic research into routine therapies is a complex multistep process which necessitates product regulation. The challenge relates to managing the expected therapeutic benefits with the potential risks and to balance the fast move to clinical trials with time-consuming cautious risk assessment. This paper will focus on the definition of mesenchymal stromal cells (MSCs, and challenges and achievements in the manufacturing process enabling their use in clinical studies. It will allude to different cellular sources, special capacities of MSCs, but also to current regulations, with a special focus on accessory material of human or animal origin, like media supplements. As cellular integrity and purity, formulation and lot release testing of the final product, validation of all procedures, and quality assurance are of utmost necessity, these topics will be addressed.

Cross-Cultural Competency and Special Education: Perceptions and Experiences of Korean Parents of Children with Special Needs.

Science.gov (United States)

Park, Jiyeon; Turnbull, Ann P.

2001-01-01

A study investigated the perceptions, levels of satisfaction, and concerns of 8 Korean parents of children with disabilities in regard to U.S. special education services. Participants expressed their satisfaction with certain aspects of the special education system, agreed they had been sent too many written materials, and used mediators.…

Special Education--Non-Special Education Achievement Gap in Math: Effects of Reporting Methods, Analytical Techniques, and Reclassification

Science.gov (United States)

Thurlow, Martha L.; Wu, Yi-Chen; Lazarus, Sheryl S.; Ysseldyke, James E.

2016-01-01

Federal regulations indicate that the achievement gap must be closed between subgroups, including the gap between special education and non-special education students. We explored the ways in which achievement trends are influenced by three methods of reporting (cross-sectional, cohort-static, and cohort-dynamic). We also investigated (a) the ways…

On rings generating supernilpotent and special atoms | France ...

African Journals Online (AJOL)

We study prime rings which generate supernilpotent (respectively special) atoms, that is, atoms of the lattice of all supernilpotent (respectively special) radicals. A prime ring A is called a **-ring if the smallest special class containing A is closed under semiprime homomorphic images of A. A semiprime ring A whose every ...

Directed cell migration in the presence of obstacles

Directory of Open Access Journals (Sweden)

Grima Ramon

2007-01-01

Full Text Available Abstract Background Chemotactic movement is a common feature of many cells and microscopic organisms. In vivo, chemotactic cells have to follow a chemotactic gradient and simultaneously avoid the numerous obstacles present in their migratory path towards the chemotactic source. It is not clear how cells detect and avoid obstacles, in particular whether they need a specialized biological mechanism to do so. Results We propose that cells can sense the presence of obstacles and avoid them because obstacles interfere with the chemical field. We build a model to test this hypothesis and find that this naturally enables efficient at-a-distance sensing to be achieved with no need for a specific and active obstacle-sensing mechanism. We find that (i the efficiency of obstacle avoidance depends strongly on whether the chemotactic chemical reacts or remains unabsorbed at the obstacle surface. In particular, it is found that chemotactic cells generally avoid absorbing barriers much more easily than non-absorbing ones. (ii The typically low noise in a cell's motion hinders the ability to avoid obstacles. We also derive an expression estimating the typical distance traveled by chemotactic cells in a 3D random distribution of obstacles before capture; this is a measure of the distance over which chemotaxis is viable as a means of directing cells from one point to another in vivo. Conclusion Chemotactic cells, in many cases, can avoid obstacles by simply following the spatially perturbed chemical gradients around obstacles. It is thus unlikely that they have developed specialized mechanisms to cope with environments having low to moderate concentrations of obstacles.

Danish Special Operations - Comprehensive Reorganization and Innovation are Necessary

DEFF Research Database (Denmark)

Jensen, Lars H. Ehrensvärd

This fourth paper in a series of research briefs about Danish special operations is focusing on how a "system's failure" has blocked the development of Danish special operations for almost 50 years. The brief suggests the repair of this system's failure by creating either a fourth service...... or a special operations command. The paper points out that a political decision is necessary, as there is no known empirical evidence that the conventional military has ever created any special operations institutions by it's own will. (The establishment of a Danish Special Operations Command was actually...

The motivation for special interests in individuals with autism and controls: Development and validation of the special interest motivation scale.

Science.gov (United States)