WorldWideScience

Sample records for hydropower shp development

  1. Small HydroPower (SHP) development in Nigeria: Issues ...

    African Journals Online (AJOL)

    Nigeria as of today generates less than 4000MW of electricity but has the capability of increasing her generation through small hydropower (SHP) considering unharnessed potentials in the country. In other to increase the percentage contribution of hydroelectricity to the total energy mix and to extend electricity to rural and ...

  2. Hydropower development in India

    Energy Technology Data Exchange (ETDEWEB)

    Saxena, Praveen [Govt. of India, New Delhi (India). Ministry of New and Renewable Energy], E-mail: psaxena_98@yahoo.com; Kumar, Arun [Indian Institute of Technology Roorkee, Uttarakhand (India). Alternate Hydro Energy Centre], E-mail: aheciitr@gmail.com

    2011-04-15

    India is posed for large deployment of hydropower in present conducive policy and investment environment. Growing energy demand and concern for carbon emission is making hydropower development more favorable. The Government of India is ensuring a good performance of the new SHP stations by linking the incentives to the SHP developers with the performance of the station. (author)

  3. The trend of small hydropower development in China

    International Nuclear Information System (INIS)

    Zhou, Sheng; Zhang, Xiliang; Liu, Jinghe

    2009-01-01

    The paper makes an analysis of the status quo and existing issues of small hydropower (SHP) in China and based on the logistic growth curve model forecasts the installed capacity of SHP and cost of newly built SHP in the future. It also explores the opportunity of the clean development mechanism (CDM) in SHP projects and puts forward suggestions and recommendations on enhancing the SHP market competitiveness. (author)

  4. Head losses in small hydropower plant trash racks (SHP

    Directory of Open Access Journals (Sweden)

    N. Walczak

    2016-12-01

    Full Text Available Small hydropower plants (SHP are technical facilities that are part of alternative energy sources [Paish 2002]. They are primarily characterised by low unit power (in Poland below 5 MW and are often constructed on existing barrages. Electrical current produced by these plants is used to meet local demand. Considering the exploitation of SHPs, it is important to ensure a stable flow through turbines. Aggidis et al. [2010] analysed SHP equipment costs depending on the turbine set. The turbines are protected against damage with trash racks applied for capturing water-borne detritus, such as plant debris carried by water. However, trash racks as solid equipment of SHPs cause head losses, and as a consequence reduce the efficiency of the system. These losses result not only from the spacing of bars, their shape and the technical condition of the inlet chamber, but also from plant debris, its nature, and the quantity of accumulated material that effectively limits the flow. The plant debris captured on trash racks is characterised by diversity in terms of species composition related to the vegetation period and the area where hydraulic facilities are located. Therefore, it is important to maintain trash racks clean by regular removal of the accumulated material. In this context, modernised and newly built power plants are fitted with mechanical cleaners. In older facilities, manual intervention for regular cleaning is required. The present study analyses how the bar shape and the orientation angle of trash racks as well as the accumulated plant debris affect head losses. The results were obtained from laboratory tests. The research examined the impact the inclination angle of trash racks (30°, 60° and 80° has on head loss values for three different shapes of bars (cylindrical, angled and flat rectangular and various weight portions of plant debris (0.25, 0.375 and 0.5 kg. The summarised losses were determined by measuring the difference in water

  5. Hydropower research and development

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    This report is a compilation of information on hydropower research and development (R and D) activities of the Federal government and hydropower industry. The report includes descriptions of on-going and planned R and D activities, 1996 funding, and anticipated future funding. Summary information on R and D projects and funding is classified into eight categories: fish passage, behavior, and response; turbine-related; monitoring tool development; hydrology; water quality; dam safety; operations and maintenance; and water resources management. Several issues in hydropower R and D are briefly discussed: duplication; priorities; coordination; technical/peer review; and technology transfer/commercialization. Project information sheets from contributors are included as an appendix.

  6. Development potential for hydropower

    International Nuclear Information System (INIS)

    Laufer, F.; Groetzinger, S.; Peter, M.; Schmutz, A.

    2004-11-01

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) takes a look at the potential for the development of hydropower in Switzerland. The report updates the energy perspectives made ten years earlier. An overview of Swiss electricity production and consumption is presented and the proportion provided by hydropower is noted. Figures on installed capacity and import/export quantities are presented and discussed. Technological developments and the economical frameworks involved are discussed, as are regulatory measures that can be taken. Theoretical and technically realisable potentials for increased use of hydropower are discussed. The methods used to do this are examined. Strategies and measures to be taken are listed and discussed. An appendix includes data sheets on power plant modelling, including examples

  7. Developing hydropower overseas

    International Nuclear Information System (INIS)

    Smith, W.B.

    1991-01-01

    This article examines how the National Hydropower Association (NHA) has found ways to support its members who desire to expand their business programs to foreign markets through participation in a wide range of government programs. The topics of the article include the market in developing countries, the certificate of review, products and services, and domestic and international competition

  8. Hydropower and its development

    Directory of Open Access Journals (Sweden)

    Janusz Steller

    2013-09-01

    Full Text Available Even if the documented history of hydropower reaches back as far as 5000 years ago, it owes its rapid acceleration in growth to the industrial revolution at the beginning of the nineteenth century. The end of the twentieth century brought about new challenges associated, on the one hand, with a growing demand for ancillary grid services, and on the other with new requirements for mitigating the environmental impact. Hydropower technology expansion had come about in a manner aiming to at least partially exploit the mechanical energy of sea and ocean waters. This study points out to the most important trends in and barriers to hydropower development, with particular focus on the situation in Poland. This author sees the main threats to Polish hydropower development in how it is perceived solely through the prism of the generation of a particular volume of green energy, and a total underestimation of the quality of electricity supply and the numerous non-energy benefits resulting from hydroelectric power plant operation.

  9. World Small Hydropower Development Report

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Heng; Esser, Lara [ICSGP (China); Masera, Diego [UNIDO, Vienna (Austria)

    2013-07-01

    Currently, small hydropower plants with a capacity of 10 MW, exist in 148 countries or territories worldwide. Four other countries have been identified with resource potential. This report aims to identify the development status and resource potential of small hydro in various countries, territories and regions throughout the world. Working with experts at the ground level to compile and share existing information, experiences and challenges, one comprehensive report was created. Decision-makers, stakeholders and potential investors clearly need this comprehensive information to more effectively promote small hydropower as a renewable and rural energy source for sustainable development and to overcome the existing development barriers. The findings of this report show that small hydropower potential globally is approximated at almost 173 GW. The figure is arrived by totaling data from a wide range of sources with potential compromise of data integrity to varying degrees. For example, research data on economically feasible potential were more readily available in developed countries than those in the least developed or developing countries. More than half of the world's known hydropower potential is located in Asia, around one third can be found in Europe and the Americas. It is possible in the future that more small hydropower potential might be identified both on the African and American continents. The installed small hydropower capacity (up to 10 MW) is estimated to be 75 GW in 2011/2012. The report provides detailed data for each country/region, including recommendations on the national, regional and international level.

  10. World Small Hydropower Development Report

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Heng; Esser, Lara (ICSGP (China)); Masera, Diego (UNIDO, Vienna (Austria))

    2013-07-01

    Currently, small hydropower plants with a capacity of 10 MW, exist in 148 countries or territories worldwide. Four other countries have been identified with resource potential. This report aims to identify the development status and resource potential of small hydro in various countries, territories and regions throughout the world. Working with experts at the ground level to compile and share existing information, experiences and challenges, one comprehensive report was created. Decision-makers, stakeholders and potential investors clearly need this comprehensive information to more effectively promote small hydropower as a renewable and rural energy source for sustainable development and to overcome the existing development barriers. The findings of this report show that small hydropower potential globally is approximated at almost 173 GW. The figure is arrived by totaling data from a wide range of sources with potential compromise of data integrity to varying degrees. For example, research data on economically feasible potential were more readily available in developed countries than those in the least developed or developing countries. More than half of the world's known hydropower potential is located in Asia, around one third can be found in Europe and the Americas. It is possible in the future that more small hydropower potential might be identified both on the African and American continents. The installed small hydropower capacity (up to 10 MW) is estimated to be 75 GW in 2011/2012. The report provides detailed data for each country/region, including recommendations on the national, regional and international level.

  11. Health implications of hydropower development

    International Nuclear Information System (INIS)

    Biswas, A.K.

    1982-01-01

    Hydropower development had been neglected in many countries during the past few decades, but the situation dramatically changed during the 1970s owing to the constantly increasing costs of electricity generation by fossil-fuel and nuclear power plants. Currently, hydroelectric generation accounts for approximately 23% of total global electricity supply. Much of the hydropower potential in developing countries of Africa, Asia and Latin America still remains to be exploited. Like any other source of energy, hydropower development has several health impacts. Conceptually, health implications of hydropower development can be divided into two broad categories: short-term and long-term problems. Short-term health impacts occur during the planning, construction and immediate post-construction phases, whereas long-term impacts stem from the presence of large man-made lakes, development of extensive canal systems, alteration of the ecosystem of the area, and changing socio-economic conditions. Longer-term impacts are further classified into two categories: introduction of new diseases and/or intensification of existing ones due to the improvements of the habitats of disease-carrying vectors, and health problems arising from resettlement of the people whose homes and land-holdings are inundated by the reservoirs. All these impacts are discussed in detail. Health impacts of hydropower developments have not yet been studied extensively. It is often implicitly assumed that health impacts of major dams are minor compared with other social and environmental impacts. Future studies could possibly reverse this assumption. (author)

  12. Development of severe skeletal defects in induced SHP-2-deficient adult mice: a model of skeletal malformation in humans with SHP-2 mutations

    Directory of Open Access Journals (Sweden)

    Timothy J. Bauler

    2011-03-01

    SHP-2 (encoded by PTPN11 is a ubiquitously expressed protein tyrosine phosphatase required for signal transduction by multiple different cell surface receptors. Humans with germline SHP-2 mutations develop Noonan syndrome or LEOPARD syndrome, which are characterized by cardiovascular, neurological and skeletal abnormalities. To study how SHP-2 regulates tissue homeostasis in normal adults, we used a conditional SHP-2 mouse mutant in which loss of expression of SHP-2 was induced in multiple tissues in response to drug administration. Induced deletion of SHP-2 resulted in impaired hematopoiesis, weight loss and lethality. Most strikingly, induced SHP-2-deficient mice developed severe skeletal abnormalities, including kyphoses and scolioses of the spine. Skeletal malformations were associated with alterations in cartilage and a marked increase in trabecular bone mass. Osteoclasts were essentially absent from the bones of SHP-2-deficient mice, thus accounting for the osteopetrotic phenotype. Studies in vitro revealed that osteoclastogenesis that was stimulated by macrophage colony-stimulating factor (M-CSF and receptor activator of nuclear factor kappa B ligand (RANKL was defective in SHP-2-deficient mice. At least in part, this was explained by a requirement for SHP-2 in M-CSF-induced activation of the pro-survival protein kinase AKT in hematopoietic precursor cells. These findings illustrate an essential role for SHP-2 in skeletal growth and remodeling in adults, and reveal some of the cellular and molecular mechanisms involved. The model is predicted to be of further use in understanding how SHP-2 regulates skeletal morphogenesis, which could lead to the development of novel therapies for the treatment of skeletal malformations in human patients with SHP-2 mutations.

  13. Hydropower and Sustainable Development: A Journey

    Energy Technology Data Exchange (ETDEWEB)

    Schumann, Kristin; Saili, Lau; Taylor, Richard; Abdel-Malek, Refaat

    2010-09-15

    Hydropower produces 16% of our electricity; it is one of the world's major renewable energy resources. It is playing an important role in enabling communities around the world to meet their power and water needs. The pace of hydropower growth has been rapid but sometimes with little guidance to ensure development is based on sustainability principles. Some of the most promising initiatives to fill the void, such as the Hydropower Sustainability Assessment Protocol, have been driven by the hydropower sector itself. Efforts focus on carrying forward this momentum to obtain a tool for hydropower sustainability agreed across sectors and stakeholders.

  14. Hydropower development in the Philippines

    International Nuclear Information System (INIS)

    Lopez, P.L.

    1997-01-01

    The present policy on energy development is geared towards harnessing renewable and indigenous energy resource which can offer clean, abundant and efficient power supply for the country. a review of the current generation mix of the power system, especially the Luzon grid will establish a high dependency in imported fuel - oil and coal to power our generating plants. Thus, the policy of reducing dependence on imported fuel will depend largely on the success of tapping the alternative renewable and indigenous sources. The sustainable development era of the 90's brought fresh interest on the performance and commercial viability of indigenous and/or renewable sources of energy such as wind, solar, geothermal, natural gas and water power or hydropower. Among these alternative renewable sources, water or hydropower is the most readily available, and will produce clean domestic source of electricity - no carbon dioxide, sulfur dioxide, nitrous oxide or any other air emissions. The potential is available in most parts of the country that are mountainous and have high rainfall. In terms of production, hydropower leads as the most developed and more proven in terms of commercial viability. It is also more reliable, efficient and less expensive than geothermal, biomass, wind and solar energy, as will be shown later. (author)

  15. Hydropower

    DEFF Research Database (Denmark)

    Fenhann, Jørgen Villy; Kofoed, Jens Peter

    2010-01-01

    This chapter gives an overview of the various forms of hydropower: conventional hydropower, marine currents, tides, power from salinity gradients, ocean thermal energy conversion and wave power.......This chapter gives an overview of the various forms of hydropower: conventional hydropower, marine currents, tides, power from salinity gradients, ocean thermal energy conversion and wave power....

  16. The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana.

    Science.gov (United States)

    Ehlers, Katrin; Bhide, Amey S; Tekleyohans, Dawit G; Wittkop, Benjamin; Snowdon, Rod J; Becker, Annette

    2016-01-01

    Seed formation is a pivotal process in plant reproduction and dispersal. It begins with megagametophyte development in the ovule, followed by fertilization and subsequently coordinated development of embryo, endosperm, and maternal seed coat. Two closely related MADS-box genes, SHATTERPROOF 1 and 2 (SHP1 and SHP2) are involved in specifying ovule integument identity in Arabidopsis thaliana. The MADS box gene ARABIDOPSIS BSISTER (ABS or TT16) is required, together with SEEDSTICK (STK) for the formation of endothelium, part of the seed coat and innermost tissue layer formed by the maternal plant. Little is known about the genetic interaction of SHP1 and SHP2 with ABS and the coordination of endosperm and seed coat development. In this work, mutant and expression analysis shed light on this aspect of concerted development. Triple tt16 shp1 shp2 mutants produce malformed seedlings, seed coat formation defects, fewer seeds, and mucilage reduction. While shp1 shp2 mutants fail to coordinate the timely development of ovules, tt16 mutants show less peripheral endosperm after fertilization. Failure in coordinated division of the innermost integument layer in early ovule stages leads to inner seed coat defects in tt16 and tt16 shp1 shp2 triple mutant seeds. An antagonistic action of ABS and SHP1/SHP2 is observed in inner seed coat layer formation. Expression analysis also indicates that ABS represses SHP1, SHP2, and FRUITFUL expression. Our work shows that the evolutionary conserved Bsister genes are required not only for endothelium but also for endosperm development and genetically interact with SHP1 and SHP2 in a partially antagonistic manner.

  17. The MADS Box Genes ABS, SHP1, and SHP2 Are Essential for the Coordination of Cell Divisions in Ovule and Seed Coat Development and for Endosperm Formation in Arabidopsis thaliana.

    Directory of Open Access Journals (Sweden)

    Katrin Ehlers

    Full Text Available Seed formation is a pivotal process in plant reproduction and dispersal. It begins with megagametophyte development in the ovule, followed by fertilization and subsequently coordinated development of embryo, endosperm, and maternal seed coat. Two closely related MADS-box genes, SHATTERPROOF 1 and 2 (SHP1 and SHP2 are involved in specifying ovule integument identity in Arabidopsis thaliana. The MADS box gene ARABIDOPSIS BSISTER (ABS or TT16 is required, together with SEEDSTICK (STK for the formation of endothelium, part of the seed coat and innermost tissue layer formed by the maternal plant. Little is known about the genetic interaction of SHP1 and SHP2 with ABS and the coordination of endosperm and seed coat development. In this work, mutant and expression analysis shed light on this aspect of concerted development. Triple tt16 shp1 shp2 mutants produce malformed seedlings, seed coat formation defects, fewer seeds, and mucilage reduction. While shp1 shp2 mutants fail to coordinate the timely development of ovules, tt16 mutants show less peripheral endosperm after fertilization. Failure in coordinated division of the innermost integument layer in early ovule stages leads to inner seed coat defects in tt16 and tt16 shp1 shp2 triple mutant seeds. An antagonistic action of ABS and SHP1/SHP2 is observed in inner seed coat layer formation. Expression analysis also indicates that ABS represses SHP1, SHP2, and FRUITFUL expression. Our work shows that the evolutionary conserved Bsister genes are required not only for endothelium but also for endosperm development and genetically interact with SHP1 and SHP2 in a partially antagonistic manner.

  18. World Small Hydropower Development Report 2013 - Zimbabwe

    CSIR Research Space (South Africa)

    Jonker Klunne, W

    2013-01-01

    Full Text Available in 2006. With the current economic and political situation in Zimbabwe improving, the drive by the Government to encourage independent power producers, the prospects for the development of small hydropower are promising....

  19. Risk management of hydropower development in China

    International Nuclear Information System (INIS)

    Tang, Wenzhe; Li, Zhuoyu; Qiang, Maoshan; Wang, Shuli; Lu, Youmei

    2013-01-01

    There is a rapidly increasing demand for hydropower in China. However, little research has been conducted to systematically investigate the overall aspects of hydropower development risks. With support of the data collected from a fieldwork survey, this study reports the multiple facets of hydropower development risks in China as perceived by main project participants. All groups have a common view on the criticality of safety, and the groups also have their own priorities, i.e., resettlement of migrants, incompetence of subcontractors, project delay, inadequate or incorrect design, premature failure of facilities and ecological and environmental impacts are the key risks to clients, whereas quality of work, financial related risks, reputation, and claims and disputes are the main concerns to contractors. A case study of Three Gorges Project further demonstrates that, hydropower development risks can be effectively managed by encouraging joint efforts of all participants to achieve the goals on producing renewable energy, reducing emissions of CO 2 , and providing important social/economical benefits. Future hydropower development should emphasize the interactions between project delivery, environmental, and economical processes to reach appropriate trade-offs among involving stakeholders, by adequately considering the inter-relations between project participants' risks as well as hydropower project's externalities on a broad view. - Highlights: • Largely attributed to unforeseen geology conditions, safety is critical in hydropower development. • Resettlement of migrants is the principal risk to clients, whereas quality of works is the first concern to contractors. • One group's risks are typically related to others', needing collaborative risk management by participants. • Three Gorges Project plays a key role on producing renewable energy, and providing social/economical benefits. • Hydropower development should emphasize the interactions between

  20. Land Systems Impacts of Hydropower Development

    Science.gov (United States)

    Wu, G. C.; Torn, M. S.

    2016-12-01

    Hydropower is often seen as the low-cost, low-carbon, and high-return technology for meeting rising electricity demand and fueling economic growth. Despite the magnitude and pace of hydropower expansion in many developing countries, the potential land use and land cover change (LULCC), particularly indirect LULCC, resulting from hydropower development is poorly understood. Hydropower-driven LULCC can have multiple impacts ranging from global and local climate modification (e.g., increased extreme precipitation events or increased greenhouse gas emissions), ecosystem degradation and fragmentation, to feedbacks on hydropower generation (e.g., increased sedimentation of the reservoir). As a result, a better understanding of both direct and indirect LULCC impacts can inform a more integrated and low-impact model for energy planning in countries with transitioning or growing energy portfolios. This study uses multi-scale remote sensing imagery (Landsat, MODIS, fine-resolution commercial imagery) to estimate LULCC from past hydropower projects intended primarily for electricity generation in 12 countries in Africa, South and Central America, South Asia, and Southeast Asia. It is important to examine multiple locations to determine how socio-political and environmental context determines the magnitude of LULCC. Previous studies have called for the need to scale-up local case studies to examine "cumulative impacts" of multiple development activities within a watershed. We use a pre-test/post-test quasi-experimental design using a time series of classified images and vegetation indices before and after hydropower plant construction as the response variable in an interrupted time series regression analysis. This statistical technique measures the "treatment" effect of hydropower development on indirect LULCC. Preliminary results show land use change and landscape fragmentation following hydropower development, primarily agricultural and urban in nature. These results suggest

  1. Development potential for hydropower; Ausbaupotential der Wasserkraft

    Energy Technology Data Exchange (ETDEWEB)

    Laufer, F.; Groetzinger, S.; Peter, M.; Schmutz, A.

    2004-11-15

    This comprehensive report for the Swiss Federal Office of Energy (SFOE) takes a look at the potential for the development of hydropower in Switzerland. The report updates the energy perspectives made ten years earlier. An overview of Swiss electricity production and consumption is presented and the proportion provided by hydropower is noted. Figures on installed capacity and import/export quantities are presented and discussed. Technological developments and the economical frameworks involved are discussed, as are regulatory measures that can be taken. Theoretical and technically realisable potentials for increased use of hydropower are discussed. The methods used to do this are examined. Strategies and measures to be taken are listed and discussed. An appendix includes data sheets on power plant modelling, including examples

  2. Hydropower

    CSIR Research Space (South Africa)

    Jonker Klunne, W

    2012-10-01

    Full Text Available Hydropower is currently the most common source of renewable energy, accounting for more than 3,400 terawatts, or about 16 percent of global electricity production, in 2010. As hydropower uses a fuel—water from the hydrologic cycle...

  3. Thayer Lake Hydropower Development -- Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Matousek, Mark [ORENCO Hydropower, Palo Alto, CA (United States)

    2017-06-30

    The Thayer Lake Hydropower Development (THLD) has been under study since the late 1970’s as Angoon explored opportunities to provide lower cost renewable power to the Community and avoid the high cost of diesel generation. Kootznoowoo Inc. (Kootznoowoo), the tribal corporation for Angoon’s current and past residents, was provided the rights by Congress to develop a hydropower project within the Admiralty Island National Monument. This grant (DE-EE0002504) by the Department of Energy’s (DOE’s) Office of Indian Energy and a matching grant from the Alaska Energy Authority (AEA) were provided to Kootznoowoo to enable the design, engineering and permitting of this hydropower project on Thayer Creek. Prior to the grant, the USFS had performed a final environmental impact statement (FEIS) and issued a Record of Decision (ROD) in 2009 for a 1.2 MW hydropower project on Thayer Creek that would Angoon’s needs with substantial excess capacity for growth. Kootznoowoo hired Alaska Power & Telephone (AP&T) in 2013 to manage this project and oversee its development. AP&T and its subcontractors under Kootznoowoo’s guidance performed several activities, aligned with the task plan defined in the grant.

  4. The role of hydropower in environment ally sustainable energy development

    International Nuclear Information System (INIS)

    Gabriel, H.F.

    2005-01-01

    Hydropower has historically been the renewable energy leader, and from a technical-cost perspective, is very likely to remain the only viable renewable energy source for many countries. In recent years, hydropower has been much maligned, especially by NGOs, for not being a sustainable source of energy. Though hydropower is clearly a renewable source of energy, but the question arises whether it can also be sustainable. Hydropower can play an increasingly important role in enabling communities around the world to meet sustainability objectives. To become more accepted as a key contributor to sustainable energy systems, new and existing hydropower projects need to be built and operated in an environmentally, socially and economically sustainable manner. This paper highlights the sustain ability aspects of hydropower and discusses the criteria for selection of environmentally friendly hydropower project sites so that that hydropower can be developed in a sustainable manner and once again be considered favorably in the planning of generation mix for new energy development. Sustainability of hydropower projects involves treating both the social and environmental sustainability of the project at an early stage and including the interests of all stakeholders of the project. As a case study, the Ghazi- Barotha Hydropower Project (GBHP) in Pakistan has been selected, as it is the best example in managing the social issues and gaining public acceptance because of proper planning and addressing environmental and social issues at an early stage. (author)

  5. Development of New Micro Hydropower Turbine

    OpenAIRE

    Dousith, Phommachanh; Kurokawa, Junichi; Matsui, Jun; Choi, Young-Do

    2005-01-01

    There is a huge of available hydropower potential in the water supply system (WSS) that has been abandoned.Each time when we use a water faucet, the power of 10 to 80 watts is dissipated.In fact, this dissipated energy can be converted to useful energy by hydraulic turbine. Presently, there is not suitable turbine to use in WSS. Therefore, the new type turbine is needed to explore. In this study, Positive Displacement Turbine (PDT) is proposed. The main objective of this study is to develop n...

  6. Hydropower development trends from a technological paradigm perspective

    International Nuclear Information System (INIS)

    Xu, Jiuping; Ni, Ting; Zheng, Bobo

    2015-01-01

    Highlights: • We propose a novel concept of hydropower development technological paradigm. • We create a data analysis system to visualize the keyword foci. • Future trajectories include hybrid power systems and resources from seawater. • The HDTP consists of a three-stage evolution and a policy framework. • The HDTP provides a how-to-do solution for the soft path. - Abstract: Hydropower has long been considered the backbone of the power generation sector in low-carbon and sustainable energy systems. Yet, as reliance on hydropower has been generally declining, the world is awakening to the need to fundamentally rethink the way hydropower is developed and managed. The paper proposes a systematic methodology to research the development trends and find a more sustainable hydropower path. Literature mining using the data analysis system and the technological paradigm theory were adopted to conduct the research. The keyword visualization results were found to meet the laws for the three phases of the technological paradigm. Specific key areas, such as small hydropower plants, hybrid power systems, and hydropower from seawater were identified as past, present and near future trajectories. To further accelerate hydropower development, specific subsidies and incentives need to be provided in areas such as capital costs and technological support. The study paves the way for a soft path solution which complements the hard path in hydropower field

  7. 75 FR 65012 - Small Hydropower Development in the United States; Notice of Small/Low-Impact Hydropower Webinar

    Science.gov (United States)

    2010-10-21

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD09-9-000] Small Hydropower Development in the United States; Notice of Small/Low-Impact Hydropower Webinar October 13, 2010. The Federal Energy Regulatory Commission will host a Small/Low- Impact Hydropower Webinar on November 10, 2010, from...

  8. 76 FR 81929 - Small Hydropower Development in the United States; Notice of Small/Low-Impact Hydropower Webinar

    Science.gov (United States)

    2011-12-29

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD09-9-000] Small Hydropower Development in the United States; Notice of Small/Low-Impact Hydropower Webinar The Federal Energy Regulatory Commission will host a Small/Low- Impact Hydropower Webinar on January 25, 2012, from 12:00 noon to 1:30 p.m...

  9. 76 FR 30937 - Small Hydropower Development in the United States; Notice of Small/Low-Impact Hydropower Webinar

    Science.gov (United States)

    2011-05-27

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD09-9-000] Small Hydropower Development in the United States; Notice of Small/Low-Impact Hydropower Webinar The Federal Energy Regulatory Commission (FERC) will host a Small/ Low-Impact Hydropower Webinar on June 22, 2011, from 12 noon to 1 p.m...

  10. Hydropower in China at present and its further development

    Energy Technology Data Exchange (ETDEWEB)

    Chang, XiaoLin; Zhou, Wei [State Key Laboratory of Water Resources and Hydropower Engineering Science, Wuhan University, Wuhan 430072 (China); Liu, Xinghong [School of Civil and Architectural Engineering, Wuhan University, Wuhan 430072 (China)

    2010-11-15

    At present, China's economic development faces energy challenge, and the appropriate solution of energy bottleneck is the key to healthy, rapid and sustainable development. China's gross amount of hydraulic resource ranks first in the world; however, because of low level of development, hydraulic resource has a broad development prospect. Now, China's hydropower development is in its peak period. By the end of 2004, the gross installed hydropower capacity of China broke through 100 million kW. From there, it has remained in the top slot worldwide. The vigorous development of hydropower is necessary because of the energy shortage and environmental pollution in China in order to attain sustainable development of China's economy. Abundant hydraulic resource, huge market demands, the strategy of western development and the favorable environment of economic development provide hydropower construction with unprecedented advantages and opportunities. Chins hydropower development aims at an installed hydropower capacity of up to 194 million kW by 2010, accounting for 23.1% of the gross installed power capacity and 35% of hydropower resource. Finally, we present the general condition of Three Gorges project as well as the new mode of hydropower development of Three Gorges Project Corporation, i.e., cascade development. (author)

  11. Hydropower development and the meaning of place. Multi-ethnic hydropower struggles in Sikkim, India

    NARCIS (Netherlands)

    Dukpa, Rinchu Doma; Joshi, Deepa; Boelens, Rutgerd

    2018-01-01

    Academic research and media tend to emphasize the strong opposition to hydropower development in Sikkim, India, and position this as resistance to an environmentally-destructive, trans-local development, particularly by the culturally-rooted, ethnic minority Bhutia and Lepcha communities. There are

  12. Conflicting hydropower development and aquatic ecosystem conservation in Bhutan

    Science.gov (United States)

    Wi, S.; Yang, Y. C. E.

    2017-12-01

    Hydropower is one of the clean energy sources that many Himalayan countries are eager to develop to solve their domestic energy deficit issue such as India, Nepal and Pakistan. Like other Himalayan countries, Bhutan also has a great potential for hydropower development. However, Bhutan is one of few countries that has a domestic energy surplus and export its hydropower generation to neighboring countries (mainly to India). Exporting hydropower is one of the major economic sources in Bhutan. However, constructions of dams and reservoirs for hydropower development inevitably involve habitat fragmentation, causing a conflict of interest with the pursuit of value in aquatic ecosystem conservation. The objectives of this study is to 1) develop a distributed hydrologic model with snow and glacier module to simulate the hydrologic regimes of seven major watersheds in Bhutan; 2) apply the hydrologic model to compute hydropower generation for all existing and potential dams; 3) evaluate cascade impacts of each individual dam on downstream regions by employing three hydro-ecological indicators: the River Connectivity Index (RCI), Dendritic Connectivity Index (DCI), total affected river stretch (ARS), and 4) analyze the tradeoffs between hydropower generation and river connectivity at the national scale by means of a multiple objective genetic algorithm. Modeling results of three Pareto Fronts between ecological indicators and hydropower generation accompany with future energy export targets from the government can inform dam selections that maximizing hydropower generation while minimizing the impact on the aquatic ecosystem (Figure 1a). The impacts of climate change on these Pareto front are also explored to identify robust dam selection under changing temperature and precipitation (Figure 1b).

  13. Life cycle greenhouse gas emissions estimation for small hydropower schemes in India

    International Nuclear Information System (INIS)

    Varun; Prakash, Ravi; Bhat, I.K.

    2012-01-01

    This paper presents for the first time correlations for greenhouse gas (GHG) emissions from small hydropower schemes in India. In this paper an attempt has been made to develop life cycle GHG emissions correlations for three different types of small hydropower schemes (run-of river, canal based and dam-toe) in India. It has been found out that GHG emissions depend on the head and capacity of the small hydropower project. The results obtained from correlations show good agreement with the estimated results using EIO-LCA (Economic Input–Output-Life Cycle Assessment) technique. These correlations may be useful for the development of new small hydropower (SHP) schemes, as they can be used to predict life cycle GHG emissions based on capacity, head and type of SHP schemes. -- Highlights: ► A study has been carried out for the Life Cycle Greenhouse gas emissions estimation for SHP schemes in India. ► Around 145 SHP schemes have been studied and their GHG emissions have been estimated. ► Based upon these results correlations have been developed for three different types of SHP schemes.

  14. World Small Hydropower Development Report 2013 - Mozambique

    CSIR Research Space (South Africa)

    Jonker Klunne, W

    2013-01-01

    Full Text Available as 3 trillion cubic feet. Natural gas is exported to South Africa via a pipeline. The current electricity generation in Mozambique is dominated by hydropower which supplies 95 per cent of the electricity demand followed by 5 per cent supplied via...

  15. State Models to Incentivize and Streamline Small Hydropower Development

    Energy Technology Data Exchange (ETDEWEB)

    Curtis, Taylor [National Renewable Energy Lab. (NREL), Golden, CO (United States); Levine, Aaron [National Renewable Energy Lab. (NREL), Golden, CO (United States); Johnson, Kurt [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-10-31

    In 2016, the hydropower fleet in the United States produced more than 6 percent (approximately 265,829 gigawatt-hours [GWh]) of the total net electricity generation. The median-size hydroelectric facility in the United States is 1.6 MW and 75 percent of total facilities have a nameplate capacity of 10 MW or less. Moreover, the U.S. Department of Energy's Hydropower Vision study identified approximately 79 GW hydroelectric potential beyond what is already developed. Much of the potential identified is at low-impact new stream-reaches, existing conduits, and non-powered dams with a median project size of 10 MW or less. To optimize the potential and value of small hydropower development, state governments are crafting policies that provide financial assistance and expedite state and federal review processes for small hydroelectric projects. This report analyzes state-led initiatives and programs that incentivize and streamline small hydroelectric development.

  16. Small Hydropower Development in Rwanda: Trends, Opportunities and Challenges

    Science.gov (United States)

    Geoffrey, Gasore; Zimmerle, Daniel; Ntagwirumugara, Etienne

    2018-04-01

    The Rift Valley region of Sub-Saharan Africa represents a promising area for the development of small (facilities constructed after 2007 are connected to off-grid systems. The study provides an overview of the economic incentives for developing small hydropower systems in Rwanda and the potential contribution of that development to Rwanda’s electrification goals.

  17. Shp2 knockdown and Noonan/LEOPARD mutant Shp2-induced gastrulation defects.

    Directory of Open Access Journals (Sweden)

    Chris Jopling

    2007-12-01

    Full Text Available Shp2 is a cytoplasmic protein-tyrosine phosphatase that is essential for normal development. Activating and inactivating mutations have been identified in humans to cause the related Noonan and LEOPARD syndromes, respectively. The cell biological cause of these syndromes remains to be determined. We have used the zebrafish to assess the role of Shp2 in early development. Here, we report that morpholino-mediated knockdown of Shp2 in zebrafish resulted in defects during gastrulation. Cell tracing experiments demonstrated that Shp2 knockdown induced defects in convergence and extension cell movements. In situ hybridization using a panel of markers indicated that cell fate was not affected by Shp2 knock down. The Shp2 knockdown-induced defects were rescued by active Fyn and Yes and by active RhoA. We generated mutants of Shp2 with mutations that were identified in human patients with Noonan or LEOPARD Syndrome and established that Noonan Shp2 was activated and LEOPARD Shp2 lacked catalytic protein-tyrosine phosphatase activity. Expression of Noonan or LEOPARD mutant Shp2 in zebrafish embryos induced convergence and extension cell movement defects without affecting cell fate. Moreover, these embryos displayed craniofacial and cardiac defects, reminiscent of human symptoms. Noonan and LEOPARD mutant Shp2s were not additive nor synergistic, consistent with the mutant Shp2s having activating and inactivating roles in the same signaling pathway. Our results demonstrate that Shp2 is required for normal convergence and extension cell movements during gastrulation and that Src family kinases and RhoA were downstream of Shp2. Expression of Noonan or LEOPARD Shp2 phenocopied the craniofacial and cardiac defects of human patients. The finding that defective Shp2 signaling induced cell movement defects as early as gastrulation may have implications for the monitoring and diagnosis of Noonan and LEOPARD syndrome.

  18. Small hydropower spot prediction using SWAT and a diversion algorithm, case study: Upper Citarum Basin

    Science.gov (United States)

    Kardhana, Hadi; Arya, Doni Khaira; Hadihardaja, Iwan K.; Widyaningtyas, Riawan, Edi; Lubis, Atika

    2017-11-01

    Small-Scale Hydropower (SHP) had been important electric energy power source in Indonesia. Indonesia is vast countries, consists of more than 17.000 islands. It has large fresh water resource about 3 m of rainfall and 2 m of runoff. Much of its topography is mountainous, remote but abundant with potential energy. Millions of people do not have sufficient access to electricity, some live in the remote places. Recently, SHP development was encouraged for energy supply of the places. Development of global hydrology data provides opportunity to predict distribution of hydropower potential. In this paper, we demonstrate run-of-river type SHP spot prediction tool using SWAT and a river diversion algorithm. The use of Soil and Water Assessment Tool (SWAT) with input of CFSR (Climate Forecast System Re-analysis) of 10 years period had been implemented to predict spatially distributed flow cumulative distribution function (CDF). A simple algorithm to maximize potential head of a location by a river diversion expressing head race and penstock had been applied. Firm flow and power of the SHP were estimated from the CDF and the algorithm. The tool applied to Upper Citarum River Basin and three out of four existing hydropower locations had been well predicted. The result implies that this tool is able to support acceleration of SHP development at earlier phase.

  19. Development of Sustainability Assessment Framework in Hydropower sector

    Science.gov (United States)

    Soliha Sahimi, Nur; Turan, Faiz Mohd; Johan, Kartina

    2017-08-01

    Nowadays, Malaysian demand in energy sector was drastically increase due to technological developments. Since, hydropower is one of potential renewable energy source in Malaysia. The largest electricity utility company, Tenaga Nasional Berhad was provide an electricity to more than seven million people via independent suppliers in peninsular Malaysia and Sabah by intended a potential sustainable hydropower system. In order to increasingly the power capacity from current use, 1882 MW to more than 3000 MW by years 2020. In this study, the environmental issues and also the penalty to the responsible company especially on Tenaga Nasional Berhad (TNB) towards their project or business are one of the problems. Other than that, every project or business has to prepare a sustainability statement or sustainability report as vital to Bursa Malaysia Securities Berhad under their listing requirements. Next, the sustainability performance on their project cannot be determined to achieve the key performance indicators (KPI) satisfaction from Government, stakeholder or any responsible agencies. This study presents an exhaustive review of these studies and suggests a direction for future developments. Sustainability Assessment framework or self-assessment is decidedly as a significant framework to assist towards sustainability reporting and to produce a Sustainability index for Hydropower sector using a mathematical model study. The results reveal that, the quantitative measurement from Sustainability Assessment framework to Systematic Sustainability Asssesment tool can be produce. In doing so, it is possible to improve the performance of the project especially in hydropower planner.

  20. Ecological impacts of small hydropower in China: Insights from an emergy analysis of a case plant

    International Nuclear Information System (INIS)

    Pang, Mingyue; Zhang, Lixiao; Ulgiati, Sergio; Wang, Changbo

    2015-01-01

    The belief that small hydropower (SHP) systems are sources of clean energy with few or no ecological problems has been driving the rapid expansion of SHP plants in China and elsewhere. This paper presents an evaluation of the ecological impacts of SHP based on an emergy analysis of a plant located in Guizhou Province in southwest China. The results suggest that periodic downstream drying-up of the river is the largest contributor to the induced ecological impacts in terms of emergy cost. In 2010, the ecosystem service losses caused by downstream ecosystem degradation totaled 2.35E+18 seJ, which accounts for 38% of the total emergy utilized in the annual operation of this plant. If such losses could be avoided, i.e., if the SHP operated as designed, SHP projects would produce relatively modest impacts on the environment. When the reaches downstream of the SHP plant are not affected, the environmental loading ratio (ELR) is 2.20 and the emergy sustainability index (ESI) is 0.93; however, the ELR increases to 3.82 and ESI decreases to 0.38 when river drying-up occurs. These results indicate that China should rigorously investigate potential ecological problems of SHP development and proceed with caution rather than readily believing unjustified assumptions. - Highlights: • Ecological impacts of a SHP plant in China are analyzed using emergy synthesis. • The ecosystem degradation due to periodic drying-up was the largest emergy cost. • The eco-friendliness of SHP is questionable when it is intensively developed. • China should proceed with caution regarding the potential ecological impact of SHP

  1. The Development of Brazilian Municipalities Flooded by Hydropower Plants

    Science.gov (United States)

    Araujo, N.; Moretto, E. M.; Roquetti, D. R.; Beduschi, L. C.; Praia, A.; Pulice, S.; Albiach, E.; Athayde, S.

    2016-12-01

    Hydropower plants cause negative environmental impacts during the phases of construction and operation. On the other hand, there is a general assumption that these projects also induce local development of the affected places, since there is a great influx of social and financial capital brought locally, especially during the construction phase the relationship between hydropower plant implementation s and local development has been controversial in the Environmental Impact Assessment field, and there is no empirical evidence showing how hydroelectric dam construction affects local development. Considering municipal development as a kind of local development and operationalizing the concept of human development by adopting income, longevity and education dimensions defined by Amartya Sen, this study aimed to verify empirical evidences regarding the role of hydropower plants in human development of their flooded municipalities in Brazil. For this, we considered 134 hydroelectric plants and correspondent 641 flooded municipalities, for which 155 human development indicators were obtained for the period of 2000 to 2010. Results obtained from statistical correlation analysis and their assumption tests showed that increases in the municipal flooded area and increases in the period of flooding - to which a given municipality is submitted - were associated with lower performances of human development indicators. Specifically, increases in social inequality, poverty and lower performances of longevity and education were detected for the flooded municipalities. We also found that the financial compensation was associated with better performance of municipal income and lower performances of education and longevity. Finally, approaching the growth poles theory of François Perroux and the productive linkages theory of Albert Hirschman, we suggest that the size of the flooded areas, the flooding period and the financial compensation may lead to an enclave situation in

  2. A new framework for sustainable hydropower development project

    Science.gov (United States)

    Johan, Kartina; Turan, Faiz Mohd; Gani, Nur Syazwani Abdul

    2018-03-01

    This project studies on the establishment of a new framework for sustainable hydropower development. A hydropower development is listed as one of the prescribed activities under the Environmental Quality Order 1987. Thus, Environmental Impact Assessment (EIA) guidelines must be referred to comply with the Department of Environment (DoE) requirements. In order to execute EIA, an assessment tool that will be utilized in the final evaluation phase must be determined. The selected assessment tool that will be used is Systematic Sustainability Assessment(SSA) which is a new integrated tool to evaluate the sustainability performance. A pilot run is conducted in five different departments within the Energy Company to validate the efficiency of the SSA tool. The parameters to be evaluated are constructed aligned with the Sustainable Development Goals (SDG) to maintain the sustainability features. Consequently, the performance level of the sustainability with respect to People, Planet and Profit (3P’s) is able to be discovered during evaluation phase in the hydropower development for continuous improvement.

  3. Small hydropower and rural electrification in China

    Energy Technology Data Exchange (ETDEWEB)

    Li Ying [Ministry of Water Resources, Beijing (China). Dept. of Hydropower and Rural Electrification

    1995-07-01

    This document presents the status of the using small hydroelectric power plants (SHP) and rural electrification in China. The document approaches the general profile, role of small hydroelectric power plants in rural electrification and energy supply, background and factors back-sopping the fast development of SHP, concentrating on resources, SHP combined with water conservancy projects, policies and strategies, development of appropriate technology, timely development of SHP equipment manufacturing, economic justification of SHP development, and future prospects.

  4. Developing a module for estimating climate warming effects on hydropower pricing in California

    International Nuclear Information System (INIS)

    Guégan, Marion; Uvo, Cintia B.; Madani, Kaveh

    2012-01-01

    Climate warming is expected to alter hydropower generation in California through affecting the annual stream-flow regimes and reducing snowpack. On the other hand, increased temperatures are expected to increase hydropower demand for cooling in warm periods while decreasing demand for heating in winter, subsequently altering the annual hydropower pricing patterns. The resulting variations in hydropower supply and pricing regimes necessitate changes in reservoir operations to minimize the revenue losses from climate warming. Previous studies in California have only explored the effects of hydrological changes on hydropower generation and revenues. This study builds a long-term hydropower pricing estimation tool, based on artificial neural network (ANN), to develop pricing scenarios under different climate warming scenarios. Results suggest higher average hydropower prices under climate warming scenarios than under historical climate. The developed tool is integrated with California's Energy-Based Hydropower Optimization Model (EBHOM) to facilitate simultaneous consideration of climate warming on hydropower supply, demand and pricing. EBHOM estimates an additional 5% drop in annual revenues under a dry warming scenario when climate change impacts on pricing are considered, with respect to when such effects are ignored, underlining the importance of considering changes in hydropower demand and pricing in future studies and policy making. - Highlights: ► Addressing the major gap in previous climate change and hydropower studies in California. ► Developing an ANN-based long-term hydropower price estimation tool. ► Estimating climate change effects on hydropower demand and pricing in California. ► Investigating the sensitivity of hydropower operations to future price changes. ► Underlining the importance of consideration of climate change impacts on electricity pricing.

  5. Assessing the Ecological and Socio-Economic Impacts of Extensive Small Hydropower Development in the Western Ghats of Karnataka, India.

    Science.gov (United States)

    Jumani, S.

    2016-12-01

    The growth of small hydro-power projects (SHPs) is being widely encouraged as they are believed to be environmentally sustainable and socially equitable sources of energy. Easy policies, carbon credits and government sponsored monetary incentives have led to the mushrooming of SHPs along most tropical rivers, especially in developing countries. Our field study conducted between December, 2013 and September, 2014 assessed the social and ecological impacts of a cluster of SHPs in the biodiversity hotspot of the Western Ghats in India. Ecological impacts were studied with respect to freshwater fish assemblages, river water parameters, forest fragmentation and spread of invasive species. Social surveys were conducted to understand impacts on SHPs on socio-economic activities, resource access and human-animal conflict. Ecological impacts were found to be substantial. Freshwater fish species richness was significantly higher in un-dammed sites, and this variation in richness was explained by dam-related variables. Within dammed streams, spatial sections that were particularly damaging were identified. Fish species and guilds that were particularly susceptible to be adversely impacted were identified as indicator species. Four SHPs having a cumulative capacity of 45MW led to a direct loss of 14.5ha of forest land. Resultant loss in canopy cover and spread of invasive plant species was quantified. More than 10% of the river stretch was left de-watered due to the dams. Socially, SHPs were not as beneficial as they are believed to be. Respondents claimed that human-elephant conflict began only after SHP construction began. This relationship was examined with secondary data, and found to be true. In light of our findings, we suggest that the policy regarding SHPs be revised. Given that 6474 sites have been identified for SHP development in India, all without any individual or cumulative impact assessments or public consultations, studies to understand their impacts at the

  6. Small Hydropower Research and Development Technology Project

    Energy Technology Data Exchange (ETDEWEB)

    Blackmore, Mo [Near Space Systems, Inc.

    2013-12-06

    The objective of this work was to investigate, develop, and validate the next generation of small hydroturbine generator designs that maximize the energy transfer from flowing water to electrical power generation. What resulted from this effort was the design of a new technology hydroturbine that Near Space Systems (NSS) has named the Star*Stream© Hydroturbine. Using a design that eliminates nearly all of the shortfalls of conventional hydroturbines, the Star*Stream© Hydroturbine employs a new mechanical-to-electrical energy transfer hydro design that operates without lubrication of any kind, and does not introduce foreign chemicals or particulate matter from oil or drive shaft seal degradation into the hydro ecology. In its unique configuration, the Star*Stream© Hydroturbine is nearly environmentally inert, without the negative aspects caused by interrupting the ecological continuity, i.e., disruptions to sedimentation, water quality, habitat changes, human displacement, fish migration, etc., - while it ensures dramatically reduced timeframes to project completion. While a remarkable reduction in LCOE resulting from application of the Star*Stream© Hydroturbine technology has been the core achievement of the this effort, there have been numerous technological breakthroughs from the development effort.

  7. Valuing trade-offs of river ecosystem services in large hydropower development in Tibet, China

    Science.gov (United States)

    Yu, B.; Xu, L.

    2015-12-01

    Hydropower development can be considered as a kind of trade-offs of ecosystem services generated by human activity for their economic and energy demand, because it can increase some river ecosystem services but decrease others. In this context, an ecosystem service trade-off framework in hydropower development was proposed in this paper. It aims to identify the ecological cost of river ecosystem and serve for the ecological compensation during hydropower development, for the hydropower services cannot completely replace the regulating services of river ecosystem. The valuing trade-offs framework was integrated by the influenced ecosystem services identification and ecosystem services valuation, through ecological monitoring and ecological economic methods, respectively. With a case study of Pondo hydropower project in Tibet, China, the valuing trade-offs of river ecosystem services in large hydropower development was illustrated. The typical ecological factors including water, sediment and soil were analyzed in this study to identify the altered river ecosystem services by Pondo hydropower project. Through the field monitoring and valuation, the results showed that the Lhasa River ecosystem services value could be changed annually by Pondo hydropower project with the increment of 5.7E+8CNY, and decrement of 5.1E+7CNY. The ecological compensation for river ecosystem should be focus on water and soil conservation, reservoir dredging and tributaries habitat protection.

  8. Evaluation of small hydropower plants in Latin America and the Caribbean

    International Nuclear Information System (INIS)

    Pardo-Gomez, R.

    1991-01-01

    Latin America and the Caribbean Region has a long-standing tradition of small hydropower plant development. In the 1890s the first plants were installed in the Region, and in the first half of this century pioneering efforts were made to develop the technology. The major reason was the technical modernization of agriculture (coffee, cacao, sugar, etc.) and small-scale mining, which led to increased energy demand in isolated areas when the electrification process was just beginning in the region. However, interest in small hydropower plants (SHP) waned because of technological improvements, enhanced efficiency, lower purchase prices and installation costs of gasoline engines, and the expansion of interconnected power systems

  9. Development of environmentally advanced hydropower turbine system design concepts

    International Nuclear Information System (INIS)

    Franke, G.F.; Webb, D.R.; Fisher, R.K. Jr.

    1997-08-01

    A team worked together on the development of environmentally advanced hydro turbine design concepts to reduce hydropower''s impact on the environment, and to improve the understanding of the technical and environmental issues involved, in particular, with fish survival as a result of their passage through hydro power sites. This approach brought together a turbine design and manufacturing company, biologists, a utility, a consulting engineering firm and a university research facility, in order to benefit from the synergy of diverse disciplines. Through a combination of advanced technology and engineering analyses, innovative design concepts adaptable to both new and existing hydro facilities were developed and are presented. The project was divided into 4 tasks. Task 1 investigated a broad range of environmental issues and how the issues differed throughout the country. Task 2 addressed fish physiology and turbine physics. Task 3 investigated individual design elements needed for the refinement of the three concept families defined in Task 1. Advanced numerical tools for flow simulation in turbines are used to quantify characteristics of flow and pressure fields within turbine water passageways. The issues associated with dissolved oxygen enhancement using turbine aeration are presented. The state of the art and recent advancements of this technology are reviewed. Key elements for applying turbine aeration to improve aquatic habitat are discussed and a review of the procedures for testing of aerating turbines is presented. In Task 4, the results of the Tasks were assembled into three families of design concepts to address the most significant issues defined in Task 1. The results of the work conclude that significant improvements in fish passage survival are achievable

  10. Development of environmentally advanced hydropower turbine system design concepts

    Energy Technology Data Exchange (ETDEWEB)

    Franke, G.F.; Webb, D.R.; Fisher, R.K. Jr. [Voith Hydro, Inc. (United States)] [and others

    1997-08-01

    A team worked together on the development of environmentally advanced hydro turbine design concepts to reduce hydropower`s impact on the environment, and to improve the understanding of the technical and environmental issues involved, in particular, with fish survival as a result of their passage through hydro power sites. This approach brought together a turbine design and manufacturing company, biologists, a utility, a consulting engineering firm and a university research facility, in order to benefit from the synergy of diverse disciplines. Through a combination of advanced technology and engineering analyses, innovative design concepts adaptable to both new and existing hydro facilities were developed and are presented. The project was divided into 4 tasks. Task 1 investigated a broad range of environmental issues and how the issues differed throughout the country. Task 2 addressed fish physiology and turbine physics. Task 3 investigated individual design elements needed for the refinement of the three concept families defined in Task 1. Advanced numerical tools for flow simulation in turbines are used to quantify characteristics of flow and pressure fields within turbine water passageways. The issues associated with dissolved oxygen enhancement using turbine aeration are presented. The state of the art and recent advancements of this technology are reviewed. Key elements for applying turbine aeration to improve aquatic habitat are discussed and a review of the procedures for testing of aerating turbines is presented. In Task 4, the results of the Tasks were assembled into three families of design concepts to address the most significant issues defined in Task 1. The results of the work conclude that significant improvements in fish passage survival are achievable.

  11. Hydropower developments in Canada: greenhouse gas emissions, energy outputs and review of environmental impacts

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Peter G.; Cheng, Ryan; Scheelar, Catherine [Global Forest Watch Canada (Canada)

    2011-11-15

    Hydropower is an important source of energy for Canada, accounting for 60% of the electricity generation mix. It is therefore important to understand the environmental performance of such developments in terms of greenhouse gas emissions and environmental impacts. From study of the Eastmain-1 reservoir, it has been extrapolated that hydropower facilities emit between 20 and 36 kilograms of CO2 per megawatt-hour. Hydropower facilities emissions are thus significantly lower than those of fossil fuel facilities, which can emit up to 1,000 kg of CO2 per MW/h. However, hydro projects have several other environmental impacts, such as habitat degradation, bio-accumulation of methyl mercury, and important sediment flow changes. The 271 large hydropower facilities affect 130,000 km of rivers and tens of thousands square kilometres of adjacent habitat. This study pointed out that despite being a low emitter of carbon dioxide, the hydropower sector has significant environmental impacts which require further assessment.

  12. Mini-hydropower development in human province of China and its position in the national economy

    International Nuclear Information System (INIS)

    Daogao, L.

    1991-01-01

    Hunan province is situated in the southern part of the middle reaches of Yangtze River. With a population of 61 million, it covers an area of about 211,800 km 2 , equivalent to forty percents of the territorial area of France. Throughout the province, there are more than 5300 rivers and 13000 reservoirs completed before 1991, of which over 7300 mini-hydropower stations are under operation. The theoretical hydropower potential is 15320 MW among them 12990 MW can be exploited with a total installed capacity of 1320 MW and an annual generation output of 4150 GWh. The paper will describe the general condition of the hydropower resources, development of mini-hydropower in Human province and its positive role in the national economy. Additionally, the standard of classification, the type of equipment for the medium and small-sized hydropower plants and market conditions in Hunan will be also involved in the paper. 5 tabs

  13. Accelerating Sustainability by Hydropower Development in China: The Story of HydroLancang

    Directory of Open Access Journals (Sweden)

    Yan Zhang

    2017-07-01

    Full Text Available Sustainable development is a shared responsibility. Accelerating sustainability of water–energy–people nexus and building a common awareness of issues pertaining to sustainable development are essential for any sort of success in this direction. Hydropower has been a useful sustainable energy for development, yet highly controversial. This paper reviews the overall situation of hydropower development and China’s energy reforms and policies, accompanied with a case study of hydropower development the Lancang River by the HydroLancang, aiming to illustrate the two opposite sides of hydropower development—economy and environment. The paper concludes with a neutral view of hydropower as the necessary facilitator for development. Water is a shared responsibility. Hydropower might not be the optimum solution to eliminate the tension between human demand of energy and finite natural resource and the rising pressure of climate change worldwide, but it serves well as an “Electricity Bridge” before better alternatives become available. This is a more balanced view of hydropower rather than two extreme viewpoints that present themselves: on the one hand, exaggerated claims of the human power to tame the wild river, and, on the other hand, the idealistic fantasy of preserving nature by abandoning all human activity.

  14. Trade-offs Between Electricity Production from Small Hydropower Plants and Ecosystem Services in Alpine River Basins

    Science.gov (United States)

    Meier, Philipp; Schwemmle, Robin; Viviroli, Daniel

    2015-04-01

    The need for a reduction in greenhouse gas emissions and the decision to phase out nuclear power plants in Switzerland and Germany increases pressure to develop the remaining hydropower potential in Alpine catchments. Since most of the potential for large reservoirs is already exploited, future development focusses on small run-of-the-river hydropower plants (SHP). Being considered a relatively environment-friendly electricity source, investment in SHP is promoted through subsidies. However, SHP can have a significant impact on riverine ecosystems, especially in the Alpine region where residual flow reaches tend to be long. An increase in hydropower exploitation will therefore increase pressure on ecosystems. While a number of studies assessed the potential for hydropower development in the Alps, two main factors were so far not assessed in detail: (i) ecological impacts within a whole river network, and (ii) economic conditions under which electricity is sold. We present a framework that establishes trade-offs between multiple objectives regarding environmental impacts, electricity production and economic evaluation. While it is inevitable that some ecosystems are compromised by hydropower plants, the context of these impacts within a river network should be considered when selecting suitable sites for SHP. From an ecological point of view, the diversity of habitats, and therefore the diversity of species, should be maintained within a river basin. This asks for objectives that go beyond lumped parameters of hydrological alteration, but also consider habitat diversity and the spatial configuration. Energy production in run-of-the-river power plants depends on available discharge, which can have large fluctuations. In a deregulated electricity market with strong price variations, an economic valuation should therefore be based on the expected market value of energy produced. Trade-off curves between different objectives can help decision makers to define policies

  15. Governing the transition to renewable energy: A review of impacts and policy issues in the small hydropower boom

    International Nuclear Information System (INIS)

    Kelly-Richards, Sarah; Silber-Coats, Noah; Crootof, Arica; Tecklin, David; Bauer, Carl

    2017-01-01

    The transition to renewable energy technologies raises new and important governance questions. With small hydropower (SHP) expanding as part of renewable energy and climate mitigation strategies, this review assesses its impacts and identifies escalating policy issues. To provide a comprehensive literature review of small hydropower, we evaluated over 3600 articles and policy documents. This review identified four major concerns: (1) confusion in small hydropower definitions is convoluting scholarship and policy-making; (2) there is a lack of knowledge and acknowledgement of small hydropower’s social, environmental, and cumulative impacts; (3) small hydropower’s promotion as a climate mitigation strategy can negatively affect local communities, posing contradictions for climate change policy; and (4) institutional analysis is needed to facilitate renewable energy integration with existing environmental laws to ensure sustainable energy development. For readers interested in small hydropower, we clarify areas of confusion in definition and explain the corresponding impacts for distinct system designs. For a broader readership, we situate small hydropower implementation within international trends of renewable energy development – the contradictory impacts of climate change policy, emerging dynamics in energy finance, and reliance on market mechanisms. Our paper provides a timely contribution to scholarship on small hydropower and the transition to renewable energy. - Highlights: • Confusion in small hydropower definitions is convoluting small hydropower debates. • Small hydropower’s negative impacts are largely overlooked in policy discussions. • Small hydropower exemplifies paradoxical problems with climate change policy. • Policies needed to integrate renewable energy development with national environmental institutions.

  16. A multi-scale spatial approach to address environmental effects of small hydropower development.

    Science.gov (United States)

    McManamay, Ryan A; Samu, Nicole; Kao, Shih-Chieh; Bevelhimer, Mark S; Hetrick, Shelaine C

    2015-01-01

    Hydropower development continues to grow worldwide in developed and developing countries. While the ecological and physical responses to dam construction have been well documented, translating this information into planning for hydropower development is extremely difficult. Very few studies have conducted environmental assessments to guide site-specific or widespread hydropower development. Herein, we propose a spatial approach for estimating environmental effects of hydropower development at multiple scales, as opposed to individual site-by-site assessments (e.g., environmental impact assessment). Because the complex, process-driven effects of future hydropower development may be uncertain or, at best, limited by available information, we invested considerable effort in describing novel approaches to represent environmental concerns using spatial data and in developing the spatial footprint of hydropower infrastructure. We then use two case studies in the US, one at the scale of the conterminous US and another within two adjoining rivers basins, to examine how environmental concerns can be identified and related to areas of varying energy capacity. We use combinations of reserve-design planning and multi-metric ranking to visualize tradeoffs among environmental concerns and potential energy capacity. Spatial frameworks, like the one presented, are not meant to replace more in-depth environmental assessments, but to identify information gaps and measure the sustainability of multi-development scenarios as to inform policy decisions at the basin or national level. Most importantly, the approach should foster discussions among environmental scientists and stakeholders regarding solutions to optimize energy development and environmental sustainability.

  17. Dilemmas of hydropower development in Vietnam : between dam-induced displacement and sustainable development

    NARCIS (Netherlands)

    Ty, P.H.

    2015-01-01

    The goal of this book is to explain the controversies related to hydropower development in Vietnam in order to make policy recommendations for equitable and sustainable development. This book focuses on the analysis of emerging issues, such as land acquisition, compensation for losses, displacement

  18. Study on expression of SH2 domain-containing protein tyrosine phosphatase SHP-1 and SHP-2 in γ-ray irradiation-induced thymus lymphoma in mice

    International Nuclear Information System (INIS)

    Huang Dingde; Chen Qi; Han Ling; Cai Jianming; Li Bailong; Huang Yuecheng; Gao Jianguo; Sun Suping

    2003-01-01

    Objective: To investigate the expression of SH2 domain containing-protein tyrosine phosphatase SHP-1 and SHP-2 in γ-ray irradiation-induced thymus lymphoma in mice. Methods: Altogether 338 BALB/c mice were randomly divided into irradiation groups and controls. Irradiation groups which were irradiated with γ-rays included canceration groups confirmed with histology and uncanceration groups. The controls were fed synchronistically with irradiation groups. The expression of SHP-1 and SHP-2 was detected with Western blot in thymus cells. Results: The expression of SHP-1 in canceration groups was much higher than that in uncanceration groups and controls significantly, while the expression of SHP-2 in canceration groups was higher than that in uncanceration groups and controls. When authors detected the expression of SHP-2 with Western blot, the authors found another protein with a molecular weight of 55x10 3 , which expression in canceration groups was higher than that in uncanceration groups and controls. Conclusion: The expression of SH2 domain-containing protein tyrosine phosphatase SHP-1 and SHP-2 is significantly increased in canceration groups, suggesting that SHP-1 and SHP-2 may be related with γ-ray induced thymus lymphoma in mice. Further research is expected on the relationship between development of cancer and SHP-1 and SHP-2

  19. A Multi-Year Plan for Research, Development, and Prototype Testing of Standard Modular Hydropower Technology

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Welch, Tim [U.S. Department of Energy (DOE), Washington, DC (United States).Office of Energy Efficiency and Renewable Energy (EERE); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stewart, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Kyutae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevelhimer, Mark S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burress, Timothy A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pracheil, Brenda M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pries, Jason L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); O' Connor, Patrick W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Curd, Shelaine L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ekici, Kivanc [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Papanicolaou, Thanos [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Tsakiris, Achilleas [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Kutz, Benjamin [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Univ. of Tennessee, Knoxville, TN (United States); Bishop, Norm [Knight Piesold, Denver, CO (United States); McKeown, Alisha [McKeown and Associates, Moberly, MO (United States); Rabon, Daniel [U.S. Department of Energy (DOE), Washington, DC (United States).Office of Energy Efficiency and Renewable Energy (EERE); Zimmerman, Gregory P. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Uria Martinez, Rocio [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); McManamay, Ryan A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-02-01

    The Multi-Year Plan for Research, Development, and Prototype Testing of Standard Modular Hydropower Technology (MYRP) presents a strategy for specifying, designing, testing, and demonstrating the efficacy of standard modular hydropower (SMH) as an environmentally compatible and cost-optimized renewable electricity generation technology. The MYRP provides the context, background, and vision for testing the SMH hypothesis: if standardization, modularity, and preservation of stream functionality become essential and fully realized features of hydropower technology, project design, and regulatory processes, they will enable previously unrealized levels of new project development with increased acceptance, reduced costs, increased predictability of outcomes, and increased value to stakeholders. To achieve success in this effort, the MYRP outlines a framework of stakeholder-validated criteria, models, design tools, testing facilities, and assessment protocols that will facilitate the development of next-generation hydropower technologies.

  20. Development of hydropower sustainability assessment method in Malaysia context

    Science.gov (United States)

    Turan, Faiz Mohd; Johan, Kartina; Atiqah Omar, Nur

    2018-03-01

    Nowadays, sustainability is becoming one of the crucial requirement to business success today. This requirement is strongly supported by Bursa Malaysia. In their webpage, they stated that an entire way to business management, incorporating economic, environmental, social and governance considerations alongside financial ones, will serve as a sound business model that supports business continuity and long term value creation for stakeholders and society at large (Bursa Malaysia website, 21th April 2016). This proved that companies need to take sustainability as one of their aspect performance as well as an energy company. Apart from that, energy companies in Malaysia are facing problems as there is still no systematic assessment of sustainability. Before this, Malaysia energy companies assess their large projects based on Environmental Impact Assessments (EIAs) requirement. However, the EIAs mostly covers the environmental issues related to the projects. The EIAs give less attention to the social aspects and economical aspects. In addition, there are still not many companies comply all the three aspects together. So, this study is to help the energy companies to discover the systematic assessment of sustainability. In developing sustainable project, they need to include many criteria that cover the environmental, economic and social aspects at all stages. Thus, the new version of Systematic Sustainability Assessment (SSA) that apply the Hydropower Sustainability Assessment Protocol (HSAP) is used as a guideline to achieve sustainability in Malaysia energy companies. This tool will guide the energy company on how to assess the sustainability in their project and see the performance of the project.

  1. Development activities, challenges and prospects for the hydropower sector in Austria

    Science.gov (United States)

    Wagner, Beatrice; Hauer, Christoph; Habersack, Helmut

    2017-04-01

    This contribution intends to give an overview of hydropower development activities in Austria and deepen the knowledge on actual strategies and planning documents. Thereby, the focus is on a climate and energy policy based perspective, also analyzing economic trends at the hydropower sector due to energy market changes in the last years. This includes a comparison with other political strategies and programs dealing with hydropower exploitation based on selected countries. With respect to technology developments, a concise review on technological innovations, such as hydrokinetic energy conversion systems, and new constructive designs of conventional hydropower plants in Austria will be given. Moreover, potential impacts on environment and aquatic ecosystems are described. Finally, key challenges and prospects will be identified and discussed.

  2. Integrating Economic and Ecological Benchmarking for a Sustainable Development of Hydropower

    Directory of Open Access Journals (Sweden)

    Philipp Emanuel Hirsch

    2016-08-01

    Full Text Available Hydropower reservoirs play an increasingly important role for the global electricity supply. Reservoirs are anthropogenically-dominated ecosystems because hydropower operations induce artificial water level fluctuations (WLF that exceed natural fluctuations in frequency and amplitude. These WLF have detrimental ecological effects, which can be quantified as losses to ecosystem primary production due to lake bottoms that fall dry. To allow for a sustainable development of hydropower, these “ecological costs” of WLF need to be weighed against the “economic benefits” of hydropower that can balance and store intermittent renewable energy. We designed an economic hydropower operation model to derive WLF in large and small reservoirs for three different future energy market scenarios and quantified the according losses in ecosystem primary production in semi-natural outdoor experiments. Our results show that variations in market conditions affect WLF differently in small and large hydropower reservoirs and that increasing price volatility magnified WLF and reduced primary production. Our model allows an assessment of the trade-off between the objectives of preserving environmental resources and economic development, which lies at the core of emerging sustainability issues.

  3. An improved method for evaluating ecological suitability of hydropower development by considering water footprint and transportation connectivity in Tibet, China.

    Science.gov (United States)

    Cui, Guannan; Wang, Xuan; Xu, Linyu; Zhang, Jin; Yu, Bing

    2014-01-01

    Ecological suitability evaluation for hydropower development is effective in locating the most suitable area for construction and emphasizes a clear direction for water resources governance. In this paper, water footprints and transportation connectivity were introduced to improve the existing ecological suitability evaluation application for hydropower development by revising the defects of the traditional indicator system. The following conclusions were reached. (1) Tibet was in a state of water use surplus; the prospect of further hydropower development is positive. (2) Chamdo, Lhasa and Nyingchi excelled in water use efficiency, and Ali was placed last. Nakchu was slightly superior to Ali, but it lagged behind the southern regions. Lhasa, Chamdo, Nyingchi, Xigaze and Shannan were suitable for hydropower development, which could further meet local needs and benefit other regions of China. (3) The evaluation results were in accordance with the actual eco-environmental conditions of the built hydropower projects, indicating that current hydropower development planning was basically reasonable.

  4. Discussion about the number of machines in SHP; Discussao sobre o numero de maquinas em PCH's

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Afonso Henriques Moreira [MS Consultoria Ltda, Itajuba, MG (Brazil); Universidade Federal de Itajuba (UNIFEI), MG (Brazil); Horta, Fabio [IX Consultoria e Representacoes Ltda, Itajuba, MG (Brazil); Batista, Thiago Roberto [IX Consultoria e Representacoes Ltda, Itajuba, MG (Brazil); Universidade Federal de Itajuba (UNIFEI), MG (Brazil)

    2010-07-01

    Given the current economic and regulatory conditions, the axial SHP turbines have spread to the country only recently, with the prevailing culture of Francis turbines. It is often used double Francis, with various groups, to avoid a Kaplan option, expensive and sometimes unavailable. This paper deals with the choice between generating sets Francis and Kaplan, in order to present the basic steps for energy production calculating and operational limitations. Then, it develops a reliability analysis of small hydropower plants inserted into the electrical system, either in terms of forced or scheduled unavailability. (author)

  5. Biophysical, Socioeconomic, and Geopolitical Vulnerabilities to Hydropower Development on the Nu River, China

    Directory of Open Access Journals (Sweden)

    Desiree D. Tullos

    2013-09-01

    Full Text Available Rapid hydropower development is occurring in China's Yunnan province in response to increasing clean energy demands, exposing potential vulnerabilities of the area's ecosystems, communities, and geopolitical systems. Here, we present original data on the cultures, economics, hydro-politics, and environments of the Nu River basin, based on household surveys, analysis of geopolitical events, and hydrological, hydraulic, and landscape modeling. We identify sources of vulnerability and investigate relationships among biophysical, socioeconomic, and geopolitical elements that contribute to vulnerability. Our results illustrate the role of geographic isolation in intensifying vulnerability to hydropower development and how access to information, data uncertainty, and geopolitics influence the vulnerability of people and the environment. We emphasize specific needs for developing support mechanisms for social, ecological, and political groups that are vulnerable to hydropower development.

  6. Hydropower developments in Canada: number, size and jurisdictional and ecological distribution

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Peter G.; Hanneman, Matt; Cheng, Ryan [Global Forest Watch Canada (Canada)

    2011-08-15

    For over 200 years, energy production and consumption, along with all human activities, have been contributing to global warming. This report is part of a project that examines 10 major energy sectors to provide information on Canada's energy options in the face of climate change; this present study gives information on hydropower reservoirs and associated dams in Canada. The mapping, jurisdictional and ecological distribution of reservoirs and dams across Canada is provided herein. Canada's hydropower installations are composed of 271 large hydropower facilities covering 58,015 km2 with a capacity of 71,857 MW, accounting for 44% of Canada's total technical hydroelectric capacity. Quebec, Ontario and British Columbia are the provinces with the most large hydropower dams; 19% of the watersheds are occupied in part by hydropower reservoirs and the taiga shield, boreal shield and montane cordillera ecozones contain most of the reservoir areas. The majority of future developments are expected to be built within 5km of intact forest landscapes.

  7. Role of hydropower development for improving energy mix with reference to India

    Energy Technology Data Exchange (ETDEWEB)

    Jose, P.C.

    2010-09-15

    With more than 70% of the electricity requirement in India being contributed from thermal sources and various issues and problems such as peaking shortage, low PLF operation of many thermal generating stations etc., there is an urgent need to review the prevailing energy mix. Hydropower potential is abundantly available to the tune of about 148,700 MW and more than 75% of which remaining untapped and with all the inherent advantages associated with hydropower, the energy mix can be improved by the development of the balance huge potential.

  8. Aspects of 100 years of hydropower development in Bavaria; Streiflichter aus 100 Jahren Entwicklung der Wasserkraftnutzung in Bayern

    Energy Technology Data Exchange (ETDEWEB)

    Zeller, Anton

    2010-07-01

    For millennia the power of water was used by direct power transformation and in the year 1850 about 70000 hydroelectric power plants were running in Germany. When remote transmission of electricity became possible around the beginning of the 20{sup th} century, enormous possibilities for the development of hydropower arose. In this article the situation in Bavaria will be presented as an example and the development in the last hundred years will be shown, which has been marked by the struggle for fair electricity tariffs. In addition, this article will look into the present use of hydropower and its possible development potential. A significant role in the development of hydropower has also been played by the hydropower magazines which have been propagating the idea of hydropower. Among these are the magazines ''WasserWirtschaft'' as well as the ''wassertriebwerk'' and their respective predecessors. (orig.)

  9. Development of an ergonomics device for maintenance of hydraulic generators of Tucuruí hydropower plant.

    Science.gov (United States)

    Batista, I C; Gomes, G J C; Teles, C S; Oliveira, P F; Santos, R M; Sassi, A C; Sá, B; V, B; Pardauil, A A

    2012-01-01

    This paper aims to present an ergonomic device to assist in the maintenance of the units of Tucuruí Hydropower Plant. The development of this ergonomic device made possible to reduce maintenance time, reduce losses caused by billing, improve performance and reduce the physical strain for labors during the execution of services.

  10. Analysis of Brazilian SHP policy and its regulation scenario

    International Nuclear Information System (INIS)

    Tiago Filho, Geraldo Lucio; Rocha Galhardo, Camila; Cassia Barbosa, Adriana de; Mambeli Barros, Regina; Gracas Braga da Silva, Fernando das

    2011-01-01

    This article presents the main regulatory changes that occurred in the Brazilian power sector in 2009, along with the impacts these changes caused on the market, especially related to small hydropower (<30 MW). This study addresses regulatory issues based on inventory studies and records of basic projects, changes related to the compensation of the assured energy of SHPs in the Brazilian energy reallocation market, the socio-economic impact resulting from the construction of SHPs, SHPs in alternative resource auctions and finally the general outlook for the growth scenario for SHPs in Brazil according to the ten-year plan (2010-2019). The overall conclusions of this investigation were that the 2008/2009 biennium was a period of great changes in the regulation of small hydropower plants in Brazil, and the SHP market has shown maturity. Additionally, despite SHP being a type of technology that is completely dominated by domestic industry, in recent years, they have experienced policy disincentives caused by changes to rules that inhibit their growth. - Highlights: → Main regulatory changes in Brazilian Power Sector that have occurred in 2009. → The impact of these changes caused on market, especially about SHPs (<30 MW). → The Brazilian growth scenario for SHPs according to the ten-year plan (2010-2019). → 2008/2009 biennium was a period of changes in the Brazilian regulation of SHPs. → SHP is a type of technology that is completely dominated by domestic industry.

  11. SHP2 sails from physiology to pathology.

    Science.gov (United States)

    Tajan, Mylène; de Rocca Serra, Audrey; Valet, Philippe; Edouard, Thomas; Yart, Armelle

    2015-10-01

    Over the two past decades, mutations of the PTPN11 gene, encoding the ubiquitous protein tyrosine phosphatase SHP2 (SH2 domain-containing tyrosine phosphatase 2), have been identified as the causal factor of several developmental diseases (Noonan syndrome (NS), Noonan syndrome with multiple lentigines (NS-ML), and metachondromatosis), and malignancies (juvenile myelomonocytic leukemia). SHP2 plays essential physiological functions in organism development and homeostasis maintenance by regulating fundamental intracellular signaling pathways in response to a wide range of growth factors and hormones, notably the pleiotropic Ras/Mitogen-Activated Protein Kinase (MAPK) and the Phosphoinositide-3 Kinase (PI3K)/AKT cascades. Analysis of the biochemical impacts of PTPN11 mutations first identified both loss-of-function and gain-of-function mutations, as well as more subtle defects, highlighting the major pathophysiological consequences of SHP2 dysregulation. Then, functional genetic studies provided insights into the molecular dysregulations that link SHP2 mutants to the development of specific traits of the diseases, paving the way for the design of specific therapies for affected patients. In this review, we first provide an overview of SHP2's structure and regulation, then describe its molecular roles, notably its functions in modulating the Ras/MAPK and PI3K/AKT signaling pathways, and its physiological roles in organism development and homeostasis. In the second part, we describe the different PTPN11 mutation-associated pathologies and their clinical manifestations, with particular focus on the biochemical and signaling outcomes of NS and NS-ML-associated mutations, and on the recent advances regarding the pathophysiology of these diseases. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  12. A modeling tool to support decision making in future hydropower development in Chile

    Science.gov (United States)

    Vicuna, S.; Hermansen, C.; Cerda, J. P.; Olivares, M. A.; Gomez, T. I.; Toha, E.; Poblete, D.; Mao, L.; Falvey, M. J.; Pliscoff, P.; Melo, O.; Lacy, S.; Peredo, M.; Marquet, P. A.; Maturana, J.; Gironas, J. A.

    2017-12-01

    Modeling tools support planning by providing transparent means to assess the outcome of natural resources management alternatives within technical frameworks in the presence of conflicting objectives. Such tools, when employed to model different scenarios, complement discussion in a policy-making context. Examples of practical use of this type of tool exist, such as the Canadian public forest management, but are not common, especially in the context of developing countries. We present a tool to support the selection from a portfolio of potential future hydropower projects in Chile. This tool, developed by a large team of researchers under the guidance of the Chilean Energy Ministry, is especially relevant in the context of evident regionalism, skepticism and change in societal values in a country that has achieved a sustained growth alongside increased demands from society. The tool operates at a scale of a river reach, between 1-5 km long, on a domain that can be defined according to the scale needs of the related discussion, and its application can vary from river basins to regions or other spatial configurations that may be of interest. The tool addresses both available hydropower potential and the existence (inferred or observed) of other ecological, social, cultural and productive characteristics of the territory which are valuable to society, and provides a means to evaluate their interaction. The occurrence of each of these other valuable characteristics in the territory is measured by generating a presence-density score for each. Considering the level of constraint each characteristic imposes on hydropower development, they are weighted against each other and an aggregate score is computed. With this information, optimal trade-offs are computed between additional hydropower capacity and valuable local characteristics over the entire domain, using the classical knapsack 0-1 optimization algorithm. Various scenarios of different weightings and hydropower

  13. Hydropower in Estonia

    International Nuclear Information System (INIS)

    Raesaar, Peeter

    1997-01-01

    Long life practice has proved that small hydropower is not a beaten track in the global energy field. Before the Second World War small hydropower was rather well developed in Estonia as well. Being neglected during the years of Soviet occupation, it is rather important to help it to regain its position in the Estonian energy system once again. Our hydropower potential is not big, but it has got a good established position as an energy saving measure. By now we have some good examples of restored hydropower stations on commercial basis to be optimistic about the future

  14. Valuing the effects of hydropower development on watershed ecosystem services: Case studies in the Jiulong River Watershed, Fujian Province, China

    Science.gov (United States)

    Wang, Guihua; Fang, Qinhua; Zhang, Luoping; Chen, Weiqi; Chen, Zhenming; Hong, Huasheng

    2010-02-01

    Hydropower development brings many negative impacts on watershed ecosystems which are not fully integrated into current decision-making largely because in practice few accept the cost and benefit beyond market. In this paper, a framework was proposed to valuate the effects on watershed ecosystem services caused by hydropower development. Watershed ecosystem services were classified into four categories of provisioning, regulating, cultural and supporting services; then effects on watershed ecosystem services caused by hydropower development were identified to 21 indicators. Thereafter various evaluation techniques including the market value method, opportunity cost approach, project restoration method, travel cost method, and contingent valuation method were determined and the models were developed to valuate these indicators reflecting specific watershed ecosystem services. This approach was applied to three representative hydropower projects (Daguan, Xizaikou and Tiangong) of Jiulong River Watershed in southeast China. It was concluded that for hydropower development: (1) the value ratio of negative impacts to positive benefits ranges from 64.09% to 91.18%, indicating that the negative impacts of hydropower development should be critically studied during its environmental administration process; (2) the biodiversity loss and water quality degradation (together accounting for 80-94%) are the major negative impacts on watershed ecosystem services; (3) the average environmental cost per unit of electricity is up to 0.206 Yuan/kW h, which is about three quarters of its on-grid power tariff; and (4) the current water resource fee accounts for only about 4% of its negative impacts value, therefore a new compensatory method by paying for ecosystem services is necessary for sustainable hydropower development. These findings provide a clear picture of both positive and negative effects of hydropower development for decision-makers in the monetary term, and also provide a

  15. Managing Sustainable Development Conflicts: The Impact of Stakeholders in Small-Scale Hydropower Schemes

    Science.gov (United States)

    Watkin, Laura Jane; Kemp, Paul S.; Williams, Ian D.; Harwood, Ian A.

    2012-06-01

    The growing importance of the environment and its management has simultaneously emphasized the benefits of hydroelectric power and its environmental costs. In a changing policy climate, giving importance to renewable energy development and environmental protection, conflict potential between stakeholders is considerable. Navigation of conflict determines the scheme constructed, making sustainable hydropower a function of human choice. To meet the needs of practitioners, greater understanding of stakeholder conflict is needed. This paper presents an approach to illustrate the challenges that face small-scale hydropower development as perceived by the stakeholders involved, and how they influence decision-making. Using Gordleton Mill, Hampshire (UK), as an illustrative case, soft systems methodology, a systems modeling approach, was adopted. Through individual interviews, a range of problems were identified and conceptually modeled. Stakeholder bias towards favoring economic appraisal over intangible social and environmental aspects was identified; costs appeared more influential than profit. Conceptual evaluation of the requirements to meet a stakeholder-approved solution suggested a complex linear systems approach, considerably different from the real-life situation. The stakeholders introduced bias to problem definition by transferring self-perceived issues onto the project owner. Application of soft systems methodology caused a shift in project goals away from further investigation towards consideration of project suitability. The challenge of sustainable hydropower is global, with a need to balance environmental, economic, and social concerns. It is clear that in this type of conflict, an individual can significantly influence outcomes; highlighting the need for more structured approaches to deal with stakeholder conflicts in sustainable hydropower development.

  16. Managing sustainable development conflicts: the impact of stakeholders in small-scale hydropower schemes.

    Science.gov (United States)

    Watkin, Laura Jane; Kemp, Paul S; Williams, Ian D; Harwood, Ian A

    2012-06-01

    The growing importance of the environment and its management has simultaneously emphasized the benefits of hydroelectric power and its environmental costs. In a changing policy climate, giving importance to renewable energy development and environmental protection, conflict potential between stakeholders is considerable. Navigation of conflict determines the scheme constructed, making sustainable hydropower a function of human choice. To meet the needs of practitioners, greater understanding of stakeholder conflict is needed. This paper presents an approach to illustrate the challenges that face small-scale hydropower development as perceived by the stakeholders involved, and how they influence decision-making. Using Gordleton Mill, Hampshire (UK), as an illustrative case, soft systems methodology, a systems modeling approach, was adopted. Through individual interviews, a range of problems were identified and conceptually modeled. Stakeholder bias towards favoring economic appraisal over intangible social and environmental aspects was identified; costs appeared more influential than profit. Conceptual evaluation of the requirements to meet a stakeholder-approved solution suggested a complex linear systems approach, considerably different from the real-life situation. The stakeholders introduced bias to problem definition by transferring self-perceived issues onto the project owner. Application of soft systems methodology caused a shift in project goals away from further investigation towards consideration of project suitability. The challenge of sustainable hydropower is global, with a need to balance environmental, economic, and social concerns. It is clear that in this type of conflict, an individual can significantly influence outcomes; highlighting the need for more structured approaches to deal with stakeholder conflicts in sustainable hydropower development.

  17. A stream-scale model to optimize the water allocation for Small Hydropower Plants and the application to traditional systems

    Science.gov (United States)

    Razurel, Pierre; Niayifar, Amin; Perona, Paolo

    2017-04-01

    Hydropower plays an important role in supplying worldwide energy demand where it contributes to approximately 16% of global electricity production. Although hydropower, as an emission-free renewable energy, is a reliable source of energy to mitigate climate change, its development will increase river exploitation. The environmental impacts associated with both small hydropower plants (SHP) and traditional dammed systems have been found to the consequence of changing natural flow regime with other release policies, e.g. the minimal flow. Nowadays, in some countries, proportional allocation rules are also applied aiming to mimic the natural flow variability. For example, these dynamic rules are part of the environmental guidance in the United Kingdom and constitute an improvement in comparison to static rules. In a context in which the full hydropower potential might be reached in a close future, a solution to optimize the water allocation seems essential. In this work, we present a model that enables to simulate a wide range of water allocation rules (static and dynamic) for a specific hydropower plant and to evaluate their associated economic and ecological benefits. It is developed in the form of a graphical user interface (GUI) where, depending on the specific type of hydropower plant (i.e., SHP or traditional dammed system), the user is able to specify the different characteristics (e.g., hydrological data and turbine characteristics) of the studied system. As an alternative to commonly used policies, a new class of dynamic allocation functions (non-proportional repartition rules) is introduced (e.g., Razurel et al., 2016). The efficiency plot resulting from the simulations shows the environmental indicator and the energy produced for each allocation policies. The optimal water distribution rules can be identified on the Pareto's frontier, which is obtained by stochastic optimization in the case of storage systems (e.g., Niayifar and Perona, submitted) and by

  18. Should we build more large dams? The actual costs of hydropower megaproject development

    International Nuclear Information System (INIS)

    Ansar, Atif; Flyvbjerg, Bent; Budzier, Alexander; Lunn, Daniel

    2014-01-01

    A brisk building boom of hydropower mega-dams is underway from China to Brazil. Whether benefits of new dams will outweigh costs remains unresolved despite contentious debates. We investigate this question with the “outside view” or “reference class forecasting” based on literature on decision-making under uncertainty in psychology. We find overwhelming evidence that budgets are systematically biased below actual costs of large hydropower dams—excluding inflation, substantial debt servicing, environmental, and social costs. Using the largest and most reliable reference data of its kind and multilevel statistical techniques applied to large dams for the first time, we were successful in fitting parsimonious models to predict cost and schedule overruns. The outside view suggests that in most countries large hydropower dams will be too costly in absolute terms and take too long to build to deliver a positive risk-adjusted return unless suitable risk management measures outlined in this paper can be affordably provided. Policymakers, particularly in developing countries, are advised to prefer agile energy alternatives that can be built over shorter time horizons to energy megaprojects. - Highlights: • We investigate ex post outcomes of schedule and cost estimates of hydropower dams. • We use the “outside view” based on Kahneman and Tversky's research in psychology. • Estimates are systematically and severely biased below actual values. • Projects that take longer have greater cost overruns; bigger projects take longer. • Uplift required to de-bias systematic cost underestimation for large dams is +99%

  19. Developing a Model to Assess the Potential Impact of TUM Hydropower Turbines on Small River Ecology

    Directory of Open Access Journals (Sweden)

    Weiwei Yao

    2018-05-01

    Full Text Available Small hydropower is a renewable energy technology that is used for electricity generation worldwide, but still has potential for further development. However, during the installation of small hydropower, the ecological impacts of the power plants need to be thoroughly investigated. In addressing the challenges of energy production and minimizing the environmental impacts of small hydropower installation and operation, this study has applied an ecohydraulic model to investigate river hydrodynamics, hydromorphology, habitat, and the population impacts of small hydropower, and presented the Mum River as a case study. Two scenarios were implemented in this research to simulate the hydrodynamic, sedimentation, habitat, and population status in order to assess the potential effects caused by the TUM plant. At the Mum River, two scenarios were proposed: the TUM plant was not considered in scenario S1, but was considered in scenario S2. The model results for scenario S2 indicated that the habitat was suitable for fish species living in the Mum River, with fish population numbers between 4.6 × 103 and 6.6 × 103. The S2 results indicated that the impacts of the TUM plant were negligible when compared with S1. Although the impact of the TUM plant on the Mum River is relatively large when the discharge is high (19 m3/s, calculations based on stable flow shows that the TUM plant could function well on the river ecosystem when the discharge is low or at normal rates. Therefore, this study shows that the TUM plant would be a good option to meet the needs of energy generation whilst having a minimal impact on river habitats and changes in fish species population in similar small rivers and streams.

  20. Assessment of small versus large hydro-power developments - a Norwegian case study

    Energy Technology Data Exchange (ETDEWEB)

    Bakken, Tor Haakon; Harby, Atle

    2010-07-01

    Full text: The era of new, large hydro-power development projects seems to be over in Norway. Partly as a response to this, a large number of applications for the development of smallscale hydro power projects up to 10 MW overflow the Water Resources and Energy Directorate, resulting in an extensive development of small tributaries and water courses in Norway. This study has developed a framework for the assessment and comparison of several small versus many large hydro-power projects based on a multi-criteria analysis (MCA) approach, and further tested this approach on planned or developed projects in the Helgeland region, Norway. Multi-criteria analysis is a decision-support tool aimed at providing a systematic approach for the comparison of various alternatives with often non-commensurable and conflicting attributes. At the same time, the technique enables complex problems and various alternatives to be assessed in a transparent and simple way. The MCA-software was in our case equipped with 2 overall criteria (objectives) with a number of sub criteria; Production with sub-criteria like volume of energy production, installed effect, storage capacity and economical profit; Environmental impacts with sub-criteria like fishing interests, biodiversity, protection of unexploited nature The data used in the case study is based on the planned development of Vefsna (large project) with the energy/effect production estimated and the environmental impacts identified as part of the feasibility studies (the project never reached the authorities' licensing system with a formal EIA). The small-scale hydro-power projects used for comparison are based on realized projects in the Helgeland region and a number of proposed projects, up scaled to the size of the proposed Vefsna-development. The results from the study indicate that a large number of small-scale hydro-power projects need to be implemented in order to balance the volume of produced electricity/effect from one

  1. Joint development of China's medium/small hydropower projects with international investment

    International Nuclear Information System (INIS)

    Xiaozhang, Z.

    1991-01-01

    A general profile of development of small and medium hydropower in China, is described at first. The socio-economic impacts as well as direct financial benefit will then be analyzed. A prospective view of medium/small hydro development for year 2,000 leads to a description of needs for foreign investment in this field. Following the adoption of open policy, a series of regulations for joint venture with foreign investment have been stipulated by the government, and are briefly illustrated. Future prospect is predicted on the basis of past experiences and planning for the next decade. 3 tabs

  2. Development of Sustainability Assessment Tool for Malaysian hydropower industry: A case study

    Science.gov (United States)

    Turan, Faiz Mohd; Johan, Kartina; Abu Sofian, Muhammad Irfan

    2018-04-01

    This research deals with the development of sustainability assessment tools as a medium to assess the performance of a hydropower project compliances towards sustainability practice. Since the increasing needs of implementing sustainability practice, developed countries are utilizing sustainability tools to achieve sustainable development goals. Its inception within ASEAN countries including Malaysia is still low. The problem with most tools developed from other countries is that it is not very comprehensive as well as its implementation factors are not suitable for the local environment that is not quantified. Hence, there is a need to develop a suitable sustainable assessment tool for the Malaysian hydropower industry to comply with the sustainable development goals as a bridging gap between the governor and the practitioner. The steps of achieving this goal is separated into several parts. The first part is to identify sustainable parameters from established tools as a model for comparison to enhance new parameters. The second stage is to convert equivalent quantification value from the model to the new developed tools. The last stage is to develop software program as a mean of gaining energy company feedback with systematic sustainable reporting from the surveyor so as to be able to integrate sustainability assessment, monitoring and reporting for self-improved reporting.

  3. Hydropower in Hawaii: Developing the Wailuku River project

    International Nuclear Information System (INIS)

    Barnes, M.J.

    1993-01-01

    When the 10-MW Wailuku River Hydroelectric Project begins operating this summer, the island of Hawaii will reduce its dependence on oil. The project is illustrative of what must be done to add to the electricity supply and, at the same time, to protect the environment. The Wailuku project is the first hydro plant to be developed in Hawaii in more than 50 years and is the largest hydro facility ever built in the state. The project is being developed by Wailuku River Hydroelectric Power Co., a wholly owned subsidiary of Synergics, Inc. Hawaii Electric Light Company Inc. (HELCO) will buy the electricity generated at the project for 30 years on an as-delivered basis at its avoided cost rate, now approximately 6.71 cents per kilowatt-hour, the floor rate in the contract. The Wailuku endeavor receives rave reviews form the mayor of Hilo, the president of the utility, and local residents. The project demanded a high degree of sensitivity to environmental issues and the uniqueness of the Hawaiian culture and island setting, according to Wayne Rogers, president of Wailuku River Hydro. From the conception of this project, we have worked closely with state and local interests and have been committed to following Hawaii's plans for land use and environmentally responsible energy development

  4. Basin-scale impacts of hydropower development on the Mompós Depression wetlands, Colombia

    Science.gov (United States)

    Angarita, Héctor; Wickel, Albertus J.; Sieber, Jack; Chavarro, John; Maldonado-Ocampo, Javier A.; Herrera-R., Guido A.; Delgado, Juliana; Purkey, David

    2018-05-01

    A number of large hydropower dams are currently under development or in an advanced stage of planning in the Magdalena River basin, Colombia, spelling uncertainty for the Mompós Depression wetlands, one of the largest wetland systems in South America at 3400 km2. Annual large-scale inundation of floodplains and their associated wetlands regulates water, nutrient, and sediment cycles, which in turn sustain a wealth of ecological processes and ecosystem services, including critical food supplies. In this study, we implemented an integrated approach focused on key attributes of ecologically functional floodplains: (1) hydrologic connectivity between the river and the floodplain, and between upstream and downstream sections; (2) hydrologic variability patterns and their links to local and regional processes; and (3) the spatial scale required to sustain floodplain-associated processes and benefits, like migratory fish biodiversity. The implemented framework provides an explicit quantification of the nonlinear or direct response relationship of those considerations with hydropower development. The proposed framework was used to develop a comparative analysis of the potential effects of the hydropower expansion necessary to meet projected 2050 electricity requirements. As part of this study, we developed an enhancement of the Water Evaluation and Planning system (WEAP) that allows resolution of the floodplains water balance at a medium scale (˜ 1000 to 10 000 km2) and evaluation of the potential impacts of upstream water management practices. In the case of the Mompós Depression wetlands, our results indicate that the potential additional impacts of new hydropower infrastructure with respect to baseline conditions can range up to one order of magnitude between scenarios that are comparable in terms of energy capacity. Fragmentation of connectivity corridors between lowland floodplains and upstream spawning habitats and reduction of sediment loads show the greatest

  5. Viewpoint – The Role of the German Development Cooperation in Promoting Sustainable Hydropower

    Directory of Open Access Journals (Sweden)

    Cathleen Seeger

    2010-06-01

    Germany’s engagement in the promotion of participatory processes on dam-related issues is building on the WCD and follow-up processes, as outlined in this article. On the global level, BMZ, represented by the Deutsche Gesellschaft für Technische Zusammenarbeit (GTZ, is currently part of the Hydropower Sustainability Assessment Forum (HSAF. On the national level, one example of support is the contribution to and interaction with the Ghana Dam Dialogue, which is facilitated through two local partners: the International Water Management Institute (IWMI and the Volta Basin Development Foundation (VBDF.

  6. New Stream-reach Development: A Comprehensive Assessment of Hydropower Energy Potential in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Kao, Shih-Chieh [ORNL; McManamay, Ryan A [ORNL; Stewart, Kevin M [ORNL; Samu, Nicole M [ORNL; Hadjerioua, Boualem [ORNL; DeNeale, Scott T [ORNL; Yeasmin, Dilruba [California State University, Fresno; Pasha, M. Fayzul K. [California State University, Fresno; Oubeidillah, Abdoul A [ORNL; Smith, Brennan T [ORNL

    2014-04-01

    The rapid development of multiple national geospatial datasets related to topography, hydrology, and environmental characteristics in the past decade have provided new opportunities for the refinement of hydropower resource potential from undeveloped stream-reaches. Through 2011 to 2013, the Oak Ridge National Laboratory (ORNL) was tasked by the Department of Energy (DOE) Water Power Program to evaluate the new stream-reach development (NSD) resource potential for more than 3 million US streams. A methodology was designed that contains three main components: (1) identification of stream-reaches with high energy density, (2) topographical analysis of stream-reaches to estimate inundated surface area and reservoir storage, and (3) environmental attribution to spatially join information related to the natural ecological systems, social and cultural settings, policies, management, and legal constraints to stream-reaches of energy potential. An initial report on methodology (Hadjerioua et al., 2013) was later reviewed and revised based on the comments gathered from two peer review workshops. After implementing the assessment across the entire United States, major findings were summarized in this final report. The estimated NSD capacity and generation, including both higher-energy-density (>1 MW per reach) and lower-energy-density (<1 MW per reach) stream-reaches is 84.7 GW, around the same size as the existing US conventional hydropower nameplate capacity (79.5 GW; NHAAP, 2013). In terms of energy, the total undeveloped NSD generation is estimated to be 460 TWh/year, around 169% of average 2002 2011 net annual generation from existing conventional hydropower plants (272 TWh/year; EIA, 2013). Given the run-of-river assumption, NSD stream-reaches have higher capacity factors (53 71%), especially compared with conventional larger-storage peaking-operation projects that usually have capacity factors of around 30%. The highest potential is identified in the Pacific Northwest

  7. The use of multicriteria decision making methods to find the environmental costs of hydropower development alternatives

    International Nuclear Information System (INIS)

    Carlsen, A.J.; Wenstoep, F.

    1994-01-01

    The conference paper deals with a decision support system (DSS) developed to find the costs of environmental goods. The system is based on multicriteria decision making and uses pairwise comparisons of two and two criteria. The criteria weights are calculated with linear regression. When one criterion is monetary, all criteria weights can be expressed in monetary units when the weights are known. The DSS has been tested on a hydropower project in the area of Sauda in Norway. To represent the decision makers, three panels each consisting of three persons were formed. The persons were selected from governmental agencies, the developers, the local environmental administration and a local politician. The DSS worked well with the panels. One problem was that impacts of hydropower projects are very site specific and also hard to quantify. Therefore, a considerable amount of time was used in creating a cognitive understanding of the issues involved and how they were represented by quantitative criteria. Some had also difficulties in accepting the principle of expressing environmental goods in monetary units. The results so far are preliminary. This research work is part of the Norwegian research programme Energy, Environment and Development. 3 refs., 4 figs., 2 tabs

  8. Private equity, public affair: Hydropower financing in the Mekong Basin

    NARCIS (Netherlands)

    Merme, V.; Ahlers, R.; Gupta, J.

    2014-01-01

    Large-scale hydropower development is increasingly popular. Although international finance is a significant driver of hydropower market expansion, financial data is relatively obscure and literature remains scarce. This article tracks the financial process in hydropower development in the Mekong

  9. Opportunities for Energy Development in Water Conduits: A Report Prepared in Response to Section 7 of the Hydropower Regulatory Efficiency Act of 2013

    Energy Technology Data Exchange (ETDEWEB)

    Sale, Michael J. [BCS, Incorporated, Laurel, MD (United States); Bishop, Norman A. [Knight Piesold, Chicago, IL (United States); Reiser, Sonya L. [Knight Piesold, Chicago, IL (United States); Johnson, Kurt [Telluride Energy LLC, Grand Junction, CO (United States); Bailey, Andrea C. [BCS, Incorporated, Laurel, MD (United States); Frank, Anthony [BCS, Incorporated, Laurel, MD (United States); Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States). Environmental Sciences Division

    2014-09-01

    In Section 7 of the Hydropower Regulatory Efficiency Act (HREA) of 2013 (P.L. 113-23), Congress directed the U.S. Department of Energy (DOE) to prepare an analysis of conduit hydropower opportunities available in the United States and to present case studies that describe the potential energy generation from these types of hydropower projects. Those analyses have been included in a new DOE report to Congress, and this ORNL/TM provides additional technical details supporting that report. Conduit hydropower offers important new ways to enhance renewable energy portfolios in the United States, as well as to increase the energy efficiency of water delivery systems. Conduit hydropower projects are constructed on existing water-conveyance structures, such as irrigation canals or pressurized pipelines that deliver water to municipalities, industry, or agricultural water users. Although water conveyance infrastructures are usually designed for non-power purposes, new renewable energy can often be harvested from them without affecting their original purpose and without the need to construct new dams or diversions. Conduit hydropower differs from more conventional hydropower development in that it is generally not located on natural rivers or waterways and therefore does not involve the types of environmental impacts that are associated with hydropower. The addition of hydropower to existing water conduits can provide valuable new revenue sources from clean, renewable energy. The new energy can be used within the existing water distribution systems to offset other energy demands, or it can be sold into regional transmission systems.

  10. Technological development with reference to hydro-power, nuclear, and alternative energy technologies

    Energy Technology Data Exchange (ETDEWEB)

    Burns, T R; Baumgartner, T

    1985-01-01

    This report outlines a theoretical framework for describing and analyzing the introduction of new technologies and the development of socio-technical systems associated with such innovations. While the report is largely theoretical in nature, it refers to certain strategic aspects of the development of nuclear, hydro-power and alternative energy systems. The ease with which technological innovation and development occur, the directions they take, and the impacts they have on the social and physical environments depend not only on purely technical and economic factors. Barriers, regulators and facilitators are inherent in the socio-political, institutional and cultural structures within which any attempts at innovation and technological development take place. The final section of the report explores some of the implications of the theory for policy and strategy, including consideration of environmental policy.

  11. New Stream-reach Development (NSD): A Comprehensive Assessment of Hydropower Energy Potential in the United States Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Kao, Shih-Chieh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2014-04-25

    The U.S. Department of Energy (DOE) Water Power Program tasked Oak Ridge National Laboratory with evaluating the new stream-reach development (NSD) resource potential of more than 3 million U.S. streams in order to help individuals and organizations evaluate the feasibility of developing new hydropower sources in the United States.

  12. Development and application of the methodology to establish life extension and modernization plan of aged hydropower plants

    International Nuclear Information System (INIS)

    Kim, Jong Sung; Kwon, Hyuck Cheon; Song, Byung Hun; Kwon, Chang Seop

    2009-01-01

    This paper provides how to establish an integrated plan for LE (Life Extension) and MD (MoDernization) of aged hydropower plants. The methodology is developed through review of overseas/domestic LE/MD histories, investigation of the previous overseas methodologies and consideration of domestic practices. The methodology includes reviews of the various factors such as condition, operation and maintenance history, up-to-date technology, and economic benefit. In order to establish the life extension/modernization plan, the methodology is applied to the domestic aged hydropower plants. Finally, priority rankings and draft practice plans for LE/MD are derived.

  13. Technology Roadmap: Hydropower

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2012-07-01

    Hydropower could double its contribution by 2050, reaching 2,000 GW of global capacity and over 7,000 TWh. This achievement, driven primarily by the quest of clean electricity, could prevent annual emissions of up to 3 billion tonnes of CO2 from fossil-fuel plants. The bulk of this growth would come from large plants in emerging economies and developing countries. Hydroelectricity’s many advantages include reliability, proven technology, large storage capacity, and very low operating and maintenance costs. Hydropower is highly flexible, a precious asset for electricity network operators, especially given rapid expansion of variable generation from other renewable energy technologies such as wind power and photovoltaics. Many hydropower plants also provide flood control, irrigation, navigation and freshwater supply. The technology roadmap for Hydropower details action needed from policy makers to allow hydroelectric production to double, and addresses necessary conditions, including resolving environmental issues and gaining public acceptance.

  14. "Fish Friendly" Hydropower Turbine Development and Deployment. Alden Turbine Preliminary Engineering and Model Testing

    Energy Technology Data Exchange (ETDEWEB)

    Dixon, D. [Electric Power Research Institute, Palo Alto, CA (United States)

    2011-10-01

    This report presents the results of a collaborative research project funded by the Electric Power Research Institute (EPRI), the U.S. Department of Energy (DOE), and hydropower industry partners with the objective of completing the remaining developmental engineering required for a “fish-friendly” hydropower turbine called the Alden turbine.

  15. Compensation and Resettlement Policies after Compulsory Land Acquisition for Hydropower Development in Vietnam: Policy and Practice

    Directory of Open Access Journals (Sweden)

    Pham Huu Ty

    2013-11-01

    Full Text Available Under Vietnam’s State land ownership regime, the Government holds supreme authority over compulsory land acquisition. The results show that many improvements in land acquisition policies have been made, but poor implementation measures largely cannot prevent or even mitigate the adverse impacts on displaced persons. In particular, ineffective compensation measures and a lack of production land and livelihood alternatives accelerate the resistance of communities displaced as a result of hydropower development. The close alliance between the local government and the investor, which is considered as an “interest group”, is the main factor that leads to the ignorance of benefits of displaced people within the compulsory land acquisition process.

  16. Corporate social responsibility: Benefits for youth in hydropower development in Laos

    Science.gov (United States)

    Sparkes, Stephen

    2014-04-01

    The role of the state as regulator combined with policies on Corporate Social Responsibility (CSR) that go beyond legal requirements to establishing programmes that promote development and good international business practice is an emerging new paradigm. In this paper, the example of a state-owned company, Statkraft A.S. of Norway, and its recent hydropower investment in central Laos illustrates how policy, implementation and follow-up can lead to benefits for local communities in the impacted area of the Theun-Hinboun Expansion Project (THXP). Programmes include both support for and improvement of existing government education programmes, employment opportunities and specific programmes for youth. They have been designed to mitigate possible negative effects of the influx of workers and rapid socio-economic change in the affected area. Young people continue to have a central role in the implementation of these programmes as peer educators under the supervision of project staff and non-governmental organisations (NGOs).

  17. Local Economic Development and Hydropower Along the Brahmaputra River Basin in Northeast India

    Science.gov (United States)

    Mock, A.

    2014-12-01

    Large dams have long been controversial. They offer benefits, such as reduced greenhouse gas emissions, energy security, and local development, yet produce negative social and ecological impact, such as wildlife habitat destruction, human displacement, and the disruption of downstream fishing or agricultural industries. In the past decade, the Indian government has signed Memoranda of Understanding with hydroelectric power companies for the building of over 130 large dams on the Brahmaputra River in the state of Arunachal Pradesh in Northeast India. These dams can generate 43% of India's assessed hydropower potential to sustain India's growing economy. In addition, the Indian government claims that these dams will bring local development with needed jobs. However, local Arunachali people have protested and temporarily halted hydropower projects because of the impact of dams on their existing livelihoods. Using the North Eastern Electric Power Corporation's (NEEPCO) Ranganadi Hydroelectric Project as a case study, our project examined whether dams in Northeast India provide jobs for local people, and whether distance from the dam or work colony to a worker's hometown affects the type of job the worker received. Survey data from residents at NEEPCO's work colony in Doimukh, Arunachal Pradesh, was analyzed using SPSS (n = 18). Our research found that 100% of workers at the dam originally resided in Northeast India, with 33% from Arunachal Pradesh, and 67% from the nearby states of Assam, and Tripura. Further, our analysis revealed no statistically significant relationship between the distance to a worker's hometown and job type (p = .609). Where workers come from did not affect the type of job they received. More research using a larger sample size and additional hydroelectric project case studies is needed to further explore the relationship between worker home location and their job types.

  18. Model for 3D-visualization of streams and techno-economic estimate of locations for construction of small hydropower plants

    International Nuclear Information System (INIS)

    Izeiroski, Subija

    2012-01-01

    The main researches of this dissertation are focused to a development of a model for preliminary assesment of the hydro power potentials for small hydropower plants construction using Geographic Information System - GIS. For this purpose, in the first part of dissertation is developed a contemporary methodological approach for 3D- visualization of the land surface and river streams in a GIS platform. In the methodology approach, as input graphical data are used digitized maps in scale 1:25000, where each map covers an area of 10x14 km and consists of many layers with graphic data in shape (vector) format. Using GIS tools, from the input point and isohyetal contour data layers with different interpolation techniques have been obtained digital elevation model - DEM, which further is used for determination of additional graphic maps with useful land surface parameters such as: slope raster maps, hill shade models of the surface, different maps with hydrologic parameters and many others. The main focus of researches is directed toward the developing of contemporary methodological approaches based on GIS systems, for assessment of the hydropower potentials and selection of suitable location for small hydropower plant construction - SHPs, and especially in the mountainous hilly area that are rich with water resources. For this purpose it is done a practical analysis at a study area which encompasses the watershed area of the Brajchanska River at the east part of Prespa Lake. The main accent considering the analysis of suitable locations for SHP construction is set to the techno-engineering criteria, and in this context is made a topographic analysis regarding the slope (gradient) either of all as well of particular river streams. It is also made a hydrological analysis regarding the flow rates (discharges). The slope analysis is executed at a pixel (cell) level a swell as at a segment (line) level along a given stream. The slope value at segment level gives in GIS

  19. Prediction of small hydropower plant power production in Himreen Lake dam (HLD using artificial neural network

    Directory of Open Access Journals (Sweden)

    Ali Thaeer Hammid

    2018-03-01

    Full Text Available In developing countries, the power production is properly less than the request of power or load, and sustaining a system stability of power production is a trouble quietly. Sometimes, there is a necessary development to the correct quantity of load demand to retain a system of power production steadily. Thus, Small Hydropower Plant (SHP includes a Kaplan turbine was verified to explore its applicability. This paper concentrates on applying on Artificial Neural Networks (ANNs by approaching of Feed-Forward, Back-Propagation to make performance predictions of the hydropower plant at the Himreen lake dam-Diyala in terms of net turbine head, flow rate of water and power production that data gathered during a research over a 10 year period. The model studies the uncertainties of inputs and output operation and there's a designing to network structure and then trained by means of the entire of 3570 experimental and observed data. Furthermore, ANN offers an analyzing and diagnosing instrument effectively to model performance of the nonlinear plant. The study suggests that the ANN may predict the performance of the plant with a correlation coefficient (R between the variables of predicted and observed output that would be higher than 0.96. Keywords: Himreen Lake Dam, Small Hydropower plants, Artificial Neural Networks, Feed forward-back propagation model, Generation system's prediction

  20. Small Hydropower in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Hadjerioua, Boualem [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Johnson, Kurt [Telluride Energy, Telluride, CO (United States)

    2015-09-01

    Small hydropower, defined in this report as hydropower with a generating capacity of up to 10 MW typically built using existing dams, pipelines, and canals has substantial opportunity for growth. Existing small hydropower comprises about 75% of the current US hydropower fleet in terms of number of plants. The economic feasibility of developing new small hydropower projects has substantially improved recently, making small hydropower the type of new hydropower development most likely to occur. In 2013, Congress unanimously approved changes to simplify federal permitting requirements for small hydropower, lowering costs and reducing the amount of time required to receive federal approvals. In 2014, Congress funded a new federal incentive payment program for hydropower, currently worth approximately 1.5 cents/kWh. Federal and state grant and loan programs for small hydropower are becoming available. Pending changes in federal climate policy could benefit all renewable energy sources, including small hydropower. Notwithstanding remaining barriers, development of new small hydropower is expected to accelerate in response to recent policy changes.

  1. Hydropower: Setting a Course for Our Energy Future

    Energy Technology Data Exchange (ETDEWEB)

    2004-07-01

    Hydropower is an annual publication that provides an overview of the Department of Energy's Hydropower Program. The mission of the program is to conduct research and development that will increase the technical, societal, and environmental benefits of hydropower and provide cost-competitive technologies that enable the development of new and incremental hydropower capacity.

  2. Clean development mechanism and off-grid small-scale hydropower projects: Evaluation of additionality

    International Nuclear Information System (INIS)

    Tanwar, Nitin

    2007-01-01

    The global climate change mitigation policies and their stress on sustainable development have made electrification of rural mountainous villages, using small hydro, an attractive destination for potential clean development mechanism (CDM) projects. This invariably involves judging the additionality of such projects. The paper suggests a new approach to judge the additionality of such stand-alone small hydropower projects. This has been done by breaking up additionality into two components: external and local. The external additionality is project developer dependent. For determining the local additionality, the paper takes into account the probability of a village getting electrified over a period of time, which is kept equal to the possible crediting period. This is done by defining an electrification factor (EF) whose value depends on the degree of isolation, financial constraints and institutional constraints encountered while electrifying a mountainous village. Using this EF, the additionality of a CDM project can be judged in a much easier and accurate way. The paper is based on the data and inputs gathered during site visits to many isolated villages located in the eastern Indian Himalayas

  3. Potentials for development of hydro-powered water desalination in Jordan

    International Nuclear Information System (INIS)

    Akash, B.A.; Mohsen, M.S.

    1998-01-01

    Due to the increase in population and development in agriculture, Jordan will deplete all of its renewable sources of fresh water in the next few years. On the other hand, the level of the Dead Sea has been falling at a high rate for the past three decades, due to the diversion of water from the Jordan River for irrigation. The solution to these issues could be in finding other alternatives such as the development of hydro-powered water desalination plant. Desalted water would be produced in order to make up for the shortage of fresh water using membrane technology, and thus reserve fresh ground water for future generations. This paper finds, on an annual basis, that about 2133 million cubic meters (MCM) of water can be drawn from the Red Sea. The power generated due to difference in elevation is used to desalinate Red Sea water. About 533 MCM of fresh water is produced in such a process. The brine, which is about 1600 MCM, is discharged into the Dead Sea. (author)

  4. Design and implementation of a new autonomous sensor fish to support advanced hydropower development.

    Science.gov (United States)

    Deng, Z D; Lu, J; Myjak, M J; Martinez, J J; Tian, C; Morris, S J; Carlson, T J; Zhou, D; Hou, H

    2014-11-01

    Acceleration in development of additional conventional hydropower requires tools and methods to perform laboratory and in-field validation of turbine performance and fish passage claims. The new-generation Sensor Fish has been developed with more capabilities to accommodate a wider range of users over a broader range of turbine designs and operating environments. It provides in situ measurements of three-dimensional (3D) linear accelerations, 3D rotational velocities, 3D orientation, pressure, and temperature at a sampling frequency of 2048 Hz. It also has an automatic floatation system and built-in radio-frequency transmitter for recovery. The relative errors of the pressure, acceleration, and rotational velocity were within ±2%, ±5%, and ±5%, respectively. The accuracy of orientation was within ±4° and accuracy of temperature was ±2 °C. The new-generation Sensor Fish is becoming a major technology and being deployed for evaluating the conditions for fish passage of turbines or other hydraulic structures in both the United States and several other countries.

  5. The invisibility of fisheries in the process of hydropower development across the Amazon.

    Science.gov (United States)

    Doria, Carolina Rodrigues da Costa; Athayde, Simone; Marques, Elineide E; Lima, Maria Alice Leite; Dutka-Gianelli, Jynessa; Ruffino, Mauro Luis; Kaplan, David; Freitas, Carlos E C; Isaac, Victoria N

    2018-05-01

    We analyze the invisibility of fisheries and inadequacy of fishers' participation in the process of hydropower development in the Amazon, focusing on gaps between legally mandated and actual outcomes. Using Ostrom's institutional design principles for assessing common-pool resource management, we selected five case studies from Brazilian Amazonian watersheds to conduct an exploratory comparative case-study analysis. We identify similar problems across basins, including deficiencies in the dam licensing process; critical data gaps; inadequate stakeholder participation; violation of human rights; neglect of fishers' knowledge; lack of organization and representation by fishers' groups; and lack of governmental structure and capacity to manage dam construction activities or support fishers after dam construction. Fishers have generally been marginalized or excluded from decision-making regarding planning, construction, mitigation, compensation, and monitoring of the social-ecological impacts of hydroelectric dams. Addressing these deficiencies will require concerted investments and efforts by dam developers, government agencies and civil society, and the promotion of inter-sectorial dialogue and cross-scale participatory planning and decision-making that includes fishers and their associations.

  6. A Hydro-Economic Model for Water Level Fluctuations: Combining Limnology with Economics for Sustainable Development of Hydropower

    Science.gov (United States)

    Hirsch, Philipp Emanuel; Schillinger, Sebastian; Weigt, Hannes; Burkhardt-Holm, Patricia

    2014-01-01

    Water level fluctuations in lakes lead to shoreline displacement. The seasonality of flooding or beaching of the littoral area affects nutrient cycling, redox gradients in sediments, and life cycles of aquatic organisms. Despite the ecological importance of water level fluctuations, we still lack a method that assesses water levels in the context of hydropower operations. Water levels in reservoirs are influenced by the operator of a hydropower plant, who discharges water through the turbines or stores water in the reservoir, in a fashion that maximizes profit. This rationale governs the seasonal operation scheme and hence determines the water levels within the boundaries of the reservoir's water balance. For progress towards a sustainable development of hydropower, the benefits of this form of electricity generation have to be weighed against the possible detrimental effects of the anthropogenic water level fluctuations. We developed a hydro-economic model that combines an economic optimization function with hydrological estimators of the water balance of a reservoir. Applying this model allowed us to accurately predict water level fluctuations in a reservoir. The hydro-economic model also allowed for scenario calculation of how water levels change with climate change scenarios and with a change in operating scheme of the reservoir (increase in turbine capacity). Further model development will enable the consideration of a variety of additional parameters, such as water withdrawal for irrigation, drinking water supply, or altered energy policies. This advances our ability to sustainably manage water resources that must meet both economic and environmental demands. PMID:25526619

  7. A hydro-economic model for water level fluctuations: combining limnology with economics for sustainable development of hydropower.

    Directory of Open Access Journals (Sweden)

    Philipp Emanuel Hirsch

    Full Text Available Water level fluctuations in lakes lead to shoreline displacement. The seasonality of flooding or beaching of the littoral area affects nutrient cycling, redox gradients in sediments, and life cycles of aquatic organisms. Despite the ecological importance of water level fluctuations, we still lack a method that assesses water levels in the context of hydropower operations. Water levels in reservoirs are influenced by the operator of a hydropower plant, who discharges water through the turbines or stores water in the reservoir, in a fashion that maximizes profit. This rationale governs the seasonal operation scheme and hence determines the water levels within the boundaries of the reservoir's water balance. For progress towards a sustainable development of hydropower, the benefits of this form of electricity generation have to be weighed against the possible detrimental effects of the anthropogenic water level fluctuations. We developed a hydro-economic model that combines an economic optimization function with hydrological estimators of the water balance of a reservoir. Applying this model allowed us to accurately predict water level fluctuations in a reservoir. The hydro-economic model also allowed for scenario calculation of how water levels change with climate change scenarios and with a change in operating scheme of the reservoir (increase in turbine capacity. Further model development will enable the consideration of a variety of additional parameters, such as water withdrawal for irrigation, drinking water supply, or altered energy policies. This advances our ability to sustainably manage water resources that must meet both economic and environmental demands.

  8. A hydro-economic model for water level fluctuations: combining limnology with economics for sustainable development of hydropower.

    Science.gov (United States)

    Hirsch, Philipp Emanuel; Schillinger, Sebastian; Weigt, Hannes; Burkhardt-Holm, Patricia

    2014-01-01

    Water level fluctuations in lakes lead to shoreline displacement. The seasonality of flooding or beaching of the littoral area affects nutrient cycling, redox gradients in sediments, and life cycles of aquatic organisms. Despite the ecological importance of water level fluctuations, we still lack a method that assesses water levels in the context of hydropower operations. Water levels in reservoirs are influenced by the operator of a hydropower plant, who discharges water through the turbines or stores water in the reservoir, in a fashion that maximizes profit. This rationale governs the seasonal operation scheme and hence determines the water levels within the boundaries of the reservoir's water balance. For progress towards a sustainable development of hydropower, the benefits of this form of electricity generation have to be weighed against the possible detrimental effects of the anthropogenic water level fluctuations. We developed a hydro-economic model that combines an economic optimization function with hydrological estimators of the water balance of a reservoir. Applying this model allowed us to accurately predict water level fluctuations in a reservoir. The hydro-economic model also allowed for scenario calculation of how water levels change with climate change scenarios and with a change in operating scheme of the reservoir (increase in turbine capacity). Further model development will enable the consideration of a variety of additional parameters, such as water withdrawal for irrigation, drinking water supply, or altered energy policies. This advances our ability to sustainably manage water resources that must meet both economic and environmental demands.

  9. Development of New, Low-Head Hydropower Turbine - Modeling & Laboratory Test DE-EE0005426

    Energy Technology Data Exchange (ETDEWEB)

    Krouse, Wayne [Hydro Green Energy, Westmont, IL (United States)

    2014-12-05

    Hydro Green Energy, LLC (HGE) will complete the design, fabrication and laboratory testing of a scaled, vertically stackable, low-head hydropower turbine called the Modular Bulb Turbine (MBT). HGE will also complete a summary report that includes the laboratory testing results and analysis of the tests. Project Goals: Design, model and test modular bulb turbine for installation in numerous HGE low-head hydropower projects at non-powered USACE dams. Project Results: The sub-scale prototype was tested successfully at a leading US hydraulic laboratory. Laboratory data results agreed well with predicted results from numerical modeling.

  10. Alteration of SHP-1/p-STAT3 Signaling: A Potential Target for Anticancer Therapy

    Directory of Open Access Journals (Sweden)

    Tzu-Ting Huang

    2017-06-01

    Full Text Available The Src homology 2 (SH2 domain-containing protein tyrosine phosphatase 1 (SHP-1, a non-receptor protein tyrosine phosphatase, has been reported as a negative regulator of phosphorylated signal transducer and activator of transcription 3 (STAT3 and linked to tumor development. In this present review, we will discuss the importance and function of SHP-1/p-STAT3 signaling in nonmalignant conditions as well as malignancies, its cross-talk with other pathways, the current clinical development and the potential role of inhibitors of this pathway in anticancer therapy and clinical relevance of SHP-1/p-STAT3 in cancers. Lastly, we will summarize and highlight work involving novel drugs/compounds targeting SHP-1/p-STAT3 signaling and combined strategies that were/are discovered in our and our colleagues’ laboratories.

  11. Estimating Ecological Value of Small Hydropower Using Contingent Valuation Method: An Application to Tongjiqiao Reservoir in Zhejiang " Province, China

    Institute of Scientific and Technical Information of China (English)

    Han Hongyun; Zhao Liange; Zhang Tong

    2012-01-01

    The small hydropower (SHP) will be less competitive in the absence of environmental value. The lack of information has become an important obstacle challenging decision-makers in resource-use choices. This paper is an application of contingent valuation method (CVM) in rural China to estimate the willing- ness-to-pay (WTP) for environmental services provided by exiting hydropower station. Using the single-bounded and dichotomous- choice CVM, the ecological value of Tongjiqiao Reservoir (TJQR) is estimated, and the annual mean WTPs of single-bounded and double-bounded CVM estimation are 141.05 and 219.52 Yuan (RMB)/a, respectively. The 95% confidence interval of annual WTP on an average is 118.47, 166.79 Yuan (RMB)/a and 204.41, 236.22 (Yuan RMB)/a, respectively. In contrast, double-bounded model could obtain much more information of WTP of the inves- tigated, thus reducing the confidence interval of estimation, and enhancing the estimation accuracy of the WTP. According to the estimated mean WTP of the double-bounded CVM, the total eco- system service value of the TJQR is 15.54 million Yuan (RMB). Compared with the conventional electricity of fossil power and large hydropower, the SHP will be less competitive in the absence of non-market value, ignoring that the environmental impacts of existing SHP will undermine the healthy development of clean energy sector.

  12. Selective activation of SHP2 activity by cisplatin revealed by a novel chemical probe-based assay

    International Nuclear Information System (INIS)

    Kuo, Chun-Chen; Chu, Chi-Yuan; Lin, Jing-Jer; Lo, Lee-Chiang

    2010-01-01

    Src homology-2 (SH2) domain-containing phosphatase 2 (SHP2) is known to participate in several different signaling pathways to mediate cell growth, survival, migration, and differentiation. However, due to the lack of proper analytical tools, it is unclear whether the phosphatase activity of SHP2 is activated in most studies. We have previously developed an activity-based probe LCL2 that formed covalent linkage with catalytically active protein tyrosine phosphatases (PTPs). Here, by combining LCL2 with a SHP2 specific antibody, we established an assay system that enables the direct monitoring of SHP2 activity upon cisplatin treatment of cancer cells. The protocol is advantageous over conventional colorimetric or in-gel PTP assays as it is specific and does not require the use of radioisotope reagents. Using this assay, we found SHP2 activity was selectively activated by cisplatin. Moreover, the activation of SHP2 appeared to be specific for cisplatin as other DNA damage agents failed to activate the activity. Although the role of SHP2 activation by cisplatin treatments is still unclear to us, our results provide the first direct evidence for the activation of SHP2 during cisplatin treatments. More importantly, the concept of using activity-based probe in conjunction with target-specific antibodies could be extended to other enzyme classes.

  13. The function of Shp2 tyrosine phosphatase in the dispersal of acetylcholine receptor clusters

    Directory of Open Access Journals (Sweden)

    Madhavan Raghavan

    2008-07-01

    Full Text Available Abstract Background A crucial event in the development of the vertebrate neuromuscular junction (NMJ is the postsynaptic enrichment of muscle acetylcholine (ACh receptors (AChRs. This process involves two distinct steps: the local clustering of AChRs at synapses, which depends on the activation of the muscle-specific receptor tyrosine kinase MuSK by neural agrin, and the global dispersal of aneural or "pre-patterned" AChR aggregates, which is triggered by ACh or by synaptogenic stimuli. We and others have previously shown that tyrosine phosphatases, such as the SH2 domain-containing phosphatase Shp2, regulate AChR cluster formation in muscle cells, and that tyrosine phosphatases also mediate the dispersal of pre-patterned AChR clusters by synaptogenic stimuli, although the specific phosphatases involved in this latter step remain unknown. Results Using an assay system that allows AChR cluster assembly and disassembly to be studied separately and quantitatively, we describe a previously unrecognized role of the tyrosine phosphatase Shp2 in AChR cluster disassembly. Shp2 was robustly expressed in embryonic Xenopus muscle in vivo and in cultured myotomal muscle cells, and treatment of the muscle cultures with an inhibitor of Shp2 (NSC-87877 blocked the dispersal of pre-patterned AChR clusters by synaptogenic stimuli. In contrast, over-expression in muscle cells of either wild-type or constitutively active Shp2 accelerated cluster dispersal. Significantly, forced expression in muscle of the Shp2-activator SIRPα1 (signal regulatory protein α1 also enhanced the disassembly of AChR clusters, whereas the expression of a truncated SIRPα1 mutant that suppresses Shp2 signaling inhibited cluster disassembly. Conclusion Our results suggest that Shp2 activation by synaptogenic stimuli, through signaling intermediates such as SIRPα1, promotes the dispersal of pre-patterned AChR clusters to facilitate the selective accumulation of AChRs at developing NMJs.

  14. Present situation and future prospect of hydropower in China

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Hailun; Yan, Zheng [Department of Electrical Engineering, Shanghai Jiaotong University, Shanghai 200240 (China)

    2009-08-15

    Hydropower is a clean and renewable energy source. Considering the economic, technical and environmental benefits of hydropower, most countries give priority to its development. China has the richest hydro resources on the planet with a total theoretical hydropower potential of 694 GW. Developing hydropower is of great importance to alleviate the energy crisis and environmental pollution resulting from the rapid economic growth of China in the 21st century. This paper provides a survey of hydropower development in China. Over the last five decades, China's hydropower has developed quickly. The installed capacity of hydropower is 145.26 GW presently. Some large hydropower plants have been in operation and many are still under construction, including the Three Gorges Project (TGP) and pumped-storage power stations. Small hydropower development accelerates rural electrification of this country. (author)

  15. SHP1 Regulates Bone Mass by Directing Mesenchymal Stem Cell Differentiation

    Directory of Open Access Journals (Sweden)

    Menghui Jiang

    2016-07-01

    Full Text Available Osteoblasts and adipocytes are derived from a common precursor, mesenchymal stem cells (MSCs. Alterations in the normal fate of differentiating MSCs are involved in the development of obesity and osteoporosis. Here, we report that viable motheaten (mev mice, which are deficient in the SH2-domain-containing phosphatase-1 (SHP1, develop osteoporosis spontaneously. Consistently, MSCs from mev/mev mice exhibit significantly reduced osteogenic potential and greatly increased adipogenic potential. When MSCs were transplanted into nude mice, SHP1-deficient MSCs resulted in diminished bone formation compared with wild-type MSCs. SHP1 was found to bind to GSK3β and suppress its kinase activity by dephosphorylating pY216, thus resulting in β-catenin stabilization. Mice, in which SHP1 was deleted in MSCs using SHP1fl/flDermo1-cre, displayed significantly decreased bone mass and increased adipose tissue. Taken together, these results suggest a possible role for SHP1 in controlling tissue homeostasis through modulation of MSC differentiation via Wnt signaling regulation.

  16. Developing a workable public input process for aesthetics and recreational needs during hydropower licensing

    International Nuclear Information System (INIS)

    Howe, D.; Stimac, M.

    1993-01-01

    Aesthetics and recreation are becoming increasingly important issues during hydropower licensing. A variety of regulations and legislation mandate the protection of instream flows for aesthetic and recreational resources. These have provided impetus for determining the effects of instream flows on recreation and aesthetic resources. A public survey designed for a proposed small hydropower project, located in a heavily used recreation area, attempts to determine the aesthetic and recreational preferences for instream flows. The major components in designing the survey are discussed. The public input process is still underway, however, preliminary results indicate lower flows in the river are generally preferable by visitors of the area. This is likely because of the types of users and the recreation activities performed

  17. Development of biological criteria for the design of advanced hydropower turbines

    Energy Technology Data Exchange (ETDEWEB)

    Cada, Glenn F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Coutant, Charles C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Whitney, Richard R. [Leavenworth, WA (United States)

    1997-03-01

    A review of the literature related to turbine-passage injury mechanisms suggests the following biological criteria should be considered in the design of new turbines: (1) pressure; (2) cavitation; (3) shear and turbulence; and (4) mechanical injury. Based on the study’s review of fish behavior in relation to hydropower facilities, it provides a number of recommendations to guide both turbine design and additional research.

  18. 75 FR 67993 - Hydropower Resource Assessment at Existing Reclamation Facilities-Draft Report

    Science.gov (United States)

    2010-11-04

    ... DEPARTMENT OF THE INTERIOR Bureau of Reclamation Hydropower Resource Assessment at Existing... comment the ``Hydropower Resource Assessment at Existing Reclamation Facilities'' (HRA) Draft Report. The HRA is an assessment of the economic and technical potential for hydropower development at existing...

  19. Hydropower, social priorities and the rural–urban development divide: The case of large dams in Cambodia

    International Nuclear Information System (INIS)

    Siciliano, Giuseppina; Urban, Frauke; Kim, Sour; Dara Lonn, Pich

    2015-01-01

    Hydropower investment is a priority in many developing countries, as a means to increase electrification rates and promote national development. However, neglect of dam-affected people's needs, can make them vulnerable to the multifaceted impacts of such projects. Using the case of Cambodia's first large dam, the Kamchay dam, this paper reveals social priorities of affected communities and institutional actors linked to environmental and social implications of large hydropower projects using a preference ranking method. Qualitative research revealed concerns among dam-affected communities which included energy access, livelihood changes, environmental impacts, access to natural resources and compensation. Results also reveal divergence between national and local priorities, which in turn brings about an unequal distribution of costs and benefits of the Kamchay Dam between urban and rural areas. The paper provides recommendations to policy-makers, NGOs and international organizations regarding governance issues, consultation processes and mitigation measures. - Highlights: • We assess social priorities linked to the impacts of a large dam in Cambodia. • We examine differences between local actors in the prioritization of the impacts. • Findings show divergences between national and local priorities of dam construction. • Distribution of cost and benefit is spatially unequal between rural and urban areas.

  20. The financing of hydropower, irrigation and water supply infrastructure in developing countries

    International Nuclear Information System (INIS)

    Briscoe, J.

    1999-01-01

    A companion paper in the previous issue of this journal (Briscoe, 1999) describes the changing face of infrastructure financing in developing countries. This paper deals with the financing of major infrastructure in the water-related sectors - hydropower, water supply, and sanitation, irrigation, and overall water resources management (including the environment). The overall level of investment in water-related infrastructure in developing countries is estimated to be of the order of $65 billion annually, with the respective shares about $15 billion for hydro, $25 billion for water and sanitation and $25 billion for irrigation and drainage. About 90% of this investment comes from domestic sources, primarily from the public sector. Water-related infrastructure accounts for a large chunk - about 15% - of all government spending. This heavy dependence on the public sector means that the 'winds of change' in the respective roles of government and the private sector have major implications for the financing and structure of the water economy. The paper describes how each of the 'subsectors' is adapting to these winds of change. First, in recent years, competition and private sector provision have emerged as the characteristics of the new electricity industry. This change poses a fundamental challenge to hydro which, to a much greater degree than thermal, has risks (hydrological, geological, social and environmental) which are better assumed by the public than the private sector. The future of private hydro, and thus of hydo itself, depends heavily on the ability of the public sector to both share risks with the private sector, and to provide predictable social and environmental rules of the game. Second, the urban water supply sector is in the early stages of equally profound change. In recent years, there has been a dramatic shift towards the private sector, in developed and developing countries alike. An outline of the future shape of the a competitive urban water

  1. Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains.

    Science.gov (United States)

    Sha, Fern; Gencer, Emel Basak; Georgeon, Sandrine; Koide, Akiko; Yasui, Norihisa; Koide, Shohei; Hantschel, Oliver

    2013-09-10

    The dysregulated tyrosine kinase BCR-ABL causes chronic myelogenous leukemia in humans and forms a large multiprotein complex that includes the Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2). The expression of SHP2 is necessary for BCR-ABL-dependent oncogenic transformation, but the precise signaling mechanisms of SHP2 are not well understood. We have developed binding proteins, termed monobodies, for the N- and C-terminal SH2 domains of SHP2. Intracellular expression followed by interactome analysis showed that the monobodies are essentially monospecific to SHP2. Two crystal structures revealed that the monobodies occupy the phosphopeptide-binding sites of the SH2 domains and thus can serve as competitors of SH2-phosphotyrosine interactions. Surprisingly, the segments of both monobodies that bind to the peptide-binding grooves run in the opposite direction to that of canonical phosphotyrosine peptides, which may contribute to their exquisite specificity. When expressed in cells, monobodies targeting the N-SH2 domain disrupted the interaction of SHP2 with its upstream activator, the Grb2-associated binder 2 adaptor protein, suggesting decoupling of SHP2 from the BCR-ABL protein complex. Inhibition of either N-SH2 or C-SH2 was sufficient to inhibit two tyrosine phosphorylation events that are critical for SHP2 catalytic activity and to block ERK activation. In contrast, targeting the N-SH2 or C-SH2 revealed distinct roles of the two SH2 domains in downstream signaling, such as the phosphorylation of paxillin and signal transducer and activator of transcription 5. Our results delineate a hierarchy of function for the SH2 domains of SHP2 and validate monobodies as potent and specific antagonists of protein-protein interactions in cancer cells.

  2. The influence of mechanical gear on the efficiency of small hydropower

    Science.gov (United States)

    Ferenc, Zbigniew; Sambor, Aleksandra

    2017-11-01

    Pursuant to the "Strategy of development of renewable energy", an increase in the share of renewable energy sources in the national fuel-energy balance up to 14% by 2020 is planned in the structure of usage of primary energy carriers. The change in the participation of the clean energy in the energy balance may be done not only by the erection of new and renovation of the already existing plants, but also through an improvement of their energetic efficiency. The study presents the influence of the mechanical gear used on the quantity of energy produced by a small hydropower on the basis of SHP Rzepcze in Opole province in 2005-2010. The primary kinematic system was composed of a Francis turbine of a vertical axis, a toothed intersecting axis gear of 1:1 ratio, a belt gear of a double ratio. After a modernization the system was simplified by means of reducing the intersecting axis gear and the double ratio of the belt gear. The new kinematic system utilized a single-ratio belt gear of a vertical axis. After the kinematic system was rearranged, a significant improvement of efficiency of the small hydropower was concluded, which translates into an increase of the amount of energy produced.

  3. HDHPLUS/SHP : heavy residue hydroconversion technology

    Energy Technology Data Exchange (ETDEWEB)

    Morel, F. [Axens, Rueil Malmaison (France)

    2009-07-01

    This presentation described an integrated refinery process that achieves nearly full conversion of heavy and refractory residues into ultra high quality and ultra low sulphur transportation fuels with a yield great than 100 volume per cent. The Axens, IFP and Intevep/PDVSA Alliance combined the HDHPLUS vacuum residue slurry technology with Sequential Hydro Processing (SHP) of primary hydrocracked products. Both technologies have undergone extensive testing at a refinery in Puerto La Cruz (RPLC), Venezuela to begin production of 50,000 BPSD in 2012. The demonstration unit at Intevep has been used to investigate production of effluent for the downstream SHP processing. This paper also reviewed the SHP bench unit operations at IFP's Lyon research center in France and disclosed the final product yields and qualities. The test results have shown the expected RPLC deep conversion commercial unit performances and fully secure its design basis. tabs., figs.

  4. US hydropower resource assessment for Texas

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, J.E.

    1993-12-01

    The Department of Energy is developing an estimate of the hydropower development potential in this country. The Hydropower Evaluation Software (HES) is a computer model that was developed by the Idaho National Engineering Laboratory for this purpose. The HES measures the potential hydropower resources available in the United States, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a dBASE menu-driven software application that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report details the resource assessment results for the state of Texas.

  5. US hydropower resource assessment for Montana

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, J.E.

    1993-12-01

    The Department of Energy is developing an estimate of the hydropower development potential in this country. The Hydropower Evaluation Software (HES) is a computer model that was developed by the Idaho National Engineering Laboratory for this purpose. The HES measures the potential hydropower resources available in the United States, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a dBASE menu-driven software application that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report details the resource assessment results for the state of Montana.

  6. US hydropower resource assessment for Kansas

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, J.E.

    1993-12-01

    The Department of Energy is developing an estimate of the hydropower development potential in this country. The Hydropower Evaluation Software (HES) is a computer model that was developed by the Idaho National Engineering Laboratory for this purpose. The HES measures the potential hydropower resources available in the United States, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a dBASE menu-driven software application that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report details the resource assessment results for the state of Kansas.

  7. Hydropower and local community : A case study of the Kamchay dam, a China-funded hydropower project in Cambodia

    NARCIS (Netherlands)

    Pheakdey, Heng

    2017-01-01

    To solve its chronic power shortage, the Government of Cambodia has placed the development of hydropower as one of the national priorities. With a total of US$2.4bn in investment, China is the most prominent player in hydropower development in Cambodia. The increase of hydropower projects and

  8. U.S. Hydropower Resource Assessment - California

    Energy Technology Data Exchange (ETDEWEB)

    A. M. Conner; B. N. Rinehart; J. E. Francfort

    1998-10-01

    The U.S. Department of Energy is developing an estimate of the underdeveloped hydropower potential in the United States. For this purpose, the Idaho National Engineering and Environmental Laboratory developed a computer model called Hydropower Evaluation Software (HES). HES measures the undeveloped hydropower resources available in the United States, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a menu-driven program that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report describes the resource assessment results for the State of California.

  9. US hydropower resource assessment for New Jersey

    Energy Technology Data Exchange (ETDEWEB)

    Connor, A.M.; Francfort, J.E.

    1996-03-01

    The Department of Energy is developing an estimate of the undeveloped hydropower potential in this country. The Hydropower Evaluation Software is a computer model that was developed by the Idaho National Engineering Laboratory for this purpose. The software measures the undeveloped hydropower resources available in the United States, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a menu-driven software program that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report details the resource assessment results for the State of New Jersey.

  10. US Hydropower Resource Assessment for Massachusetts

    Energy Technology Data Exchange (ETDEWEB)

    Francfort, J.E.; Rinehart, B.N.

    1995-07-01

    The Department of Energy is developing an estimate of the undeveloped hydropower potential in the United States. The Hydropower Evaluation Software (HES) is a computer model that was developed by the Idaho National Engineering Laboratory for this purpose. The software measures the undeveloped hydropower resources available in the United States, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a menu-driven software program that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report details the resource assessment results for the Commonwealth of Massachusetts.

  11. Renewable Energy Essentials: Hydropower

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    Hydropower is currently the most common form of renewable energy and plays an important part in global power generation. Worldwide hydropower produced 3 288 TWh, just over 16% of global electricity production in 2008, and the overall technical potential for hydropower is estimated to be more than 16 400 TWh/yr.

  12. Hydro-power: a long history, a bright future

    Energy Technology Data Exchange (ETDEWEB)

    Deudney, D

    1981-07-01

    A brief history of the spread of hydro-power in the world was given. Tables showing hydro-power potential and use, and the % electricity from hydro-power for 13 countries were included along with a graph showing % hydro-power operating, planned and under construction by region. The need for committed and farsighted political leadership for future development and the possibility of hydro production reaching 4 to 6 times its present level were discussed.

  13. Yunnan’s Fast-Paced Large Hydropower Development: A Powershed-Based Approach to Critically Assessing Generation and Consumption Paradigms

    Directory of Open Access Journals (Sweden)

    Thomas Hennig

    2016-10-01

    Full Text Available Southwest China’s Yunnan province is evolving into one of the world’s largest hydro-power-producing regions. It already rivals the world’s largest hydro-producing nations. However, five of Yunnan’s six basins are international and therefore its hydropower development is of great academic and geopolitical interest. While the implementation of large projects on Yunnan’s three large rivers (Jinsha, Mekong and Nu is relatively well studied, hydropower development outside these three main streams is hardly known. Here, we identified 128 large hydropower projects (≥50 MW having a capacity of 16.5 GW, along with another 16.4 GW of other types of power generation, neither of which has been discussed in the academic literature yet. The paper utilizes a powershed approach to study the rapid hydropower development underway in Yunnan, both in its implication and challenges (at basin and administrative level as well as in its trade-offs within the broader electricity context. Yunnan’s power generation and consumption patterns are characterized by diverging interests of local/provincial usage and export utilization. Within the province, the largest (hydro- power users are energy/electricity intensive industries, which themselves have strong impacts on land use changes. Yunnan is also evolving as a major power exporter, already in 2013 exporting about one-third of its generated electricity mainly to Guangdong’s Pearl River Delta. We see a need for a critical revision of those existing generation and consumption paradigms, which includes a rethinking of major development modes, both in terms of future hydropower generation and utilization projects as well as export obligations.

  14. Hydropower Baseline Cost Modeling

    Energy Technology Data Exchange (ETDEWEB)

    O' Connor, Patrick W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Zhang, Qin Fen [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chalise, Dol Raj [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Centurion, Emma E. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-01-01

    Recent resource assessments conducted by the United States Department of Energy have identified significant opportunities for expanding hydropower generation through the addition of power to non-powered dams and on undeveloped stream-reaches. Additional interest exists in the powering of existing water resource infrastructure such as conduits and canals, upgrading and expanding existing hydropower facilities, and the construction new pumped storage hydropower. Understanding the potential future role of these hydropower resources in the nation’s energy system requires an assessment of the environmental and techno-economic issues associated with expanding hydropower generation. To facilitate these assessments, this report seeks to fill the current gaps in publically available hydropower cost-estimating tools that can support the national-scale evaluation of hydropower resources.

  15. Deletion of SHP-2 in mesenchymal stem cells causes growth retardation, limb and chest deformity, and calvarial defects in mice

    Directory of Open Access Journals (Sweden)

    Philip E. Lapinski

    2013-11-01

    In mice, induced global disruption of the Ptpn11 gene, which encodes the SHP-2 tyrosine phosphatase, results in severe skeletal abnormalities. To understand the extent to which skeletal abnormalities can be attributed to perturbation of SHP-2 function in bone-forming osteoblasts and chondrocytes, we generated mice in which disruption of Ptpn11 is restricted to mesenchymal stem cells (MSCs and their progeny, which include both cell types. MSC-lineage-specific SHP-2 knockout (MSC SHP-2 KO mice exhibited postnatal growth retardation, limb and chest deformity, and calvarial defects. These skeletal abnormalities were associated with an absence of mature osteoblasts and massive chondrodysplasia with a vast increase in the number of terminally differentiated hypertrophic chondrocytes in affected bones. Activation of mitogen activated protein kinases (MAPKs and protein kinase B (PKB; also known as AKT was impaired in bone-forming cells of MSC SHP-2 KO mice, which provides an explanation for the skeletal defects that developed. These findings reveal a cell-autonomous role for SHP-2 in bone-forming cells in mice in the regulation of skeletal development. The results add to our understanding of the pathophysiology of skeletal abnormalities observed in humans with germline mutations in the PTPN11 gene (e.g. Noonan syndrome and LEOPARD syndrome.

  16. Advanced glycation end product Nε-carboxymethyllysine induces endothelial cell injury: the involvement of SHP-1-regulated VEGFR-2 dephosphorylation.

    Science.gov (United States)

    Liu, Shing Hwa; Sheu, Wayne Huey Herng; Lee, Maw Rong; Lee, Wen Jane; Yi, Yu Chiao; Yang, Tzung Jie; Jen, Jen Fon; Pan, Hung Chuan; Shen, Chin Chang; Chen, Wen Bao; Tien, Hsing Ru; Sheu, Meei Ling

    2013-06-01

    N(ε)-carboxymethyllysine (CML), a major advanced glycation end product, plays a crucial role in diabetes-induced vascular injury. The roles of protein tyrosine phosphatases and vascular endothelial growth factor (VEGF) receptors in CML-related endothelial cell injury are still unclear. Human umbilical vein endothelial cells (HUVECs) are a commonly used human EC type. Here, we tested the hypothesis that NADPH oxidase/reactive oxygen species (ROS)-mediated SH2 domain-containing tyrosine phosphatase-1 (SHP-1) activation by CML inhibits the VEGF receptor-2 (VEGFR-2, KDR/Flk-1) activation, resulting in HUVEC injury. CML significantly inhibited cell proliferation and induced apoptosis and reduced VEGFR-2 activation in parallel with the increased SHP-1 protein expression and activity in HUVECs. Adding recombinant VEGF increased forward biological effects, which were attenuated by CML. The effects of CML on HUVECs were abolished by SHP-1 siRNA transfection. Exposure of HUVECs to CML also remarkably escalated the integration of SHP-1 with VEGFR-2. Consistently, SHP-1 siRNA transfection and pharmacological inhibitors could block this interaction and elevating [(3)H]thymidine incorporation. CML also markedly activated the NADPH oxidase and ROS production. The CML-increased SHP-1 activity in HUVECs was effectively attenuated by antioxidants. Moreover, the immunohistochemical staining of SHP-1 and CML was increased, but phospho-VEGFR-2 staining was decreased in the aortic endothelium of streptozotocin-induced and high-fat diet-induced diabetic mice. We conclude that a pathway of tyrosine phosphatase SHP-1-regulated VEGFR-2 dephosphorylation through NADPH oxidase-derived ROS is involved in the CML-triggered endothelial cell dysfunction/injury. These findings suggest new insights into the development of therapeutic approaches to reduce diabetic vascular complications. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

  17. Development and Implications of a Predictive Cost Methodology for Modular Pumped Storage Hydropower (m-PSH) Projects in the United States

    Energy Technology Data Exchange (ETDEWEB)

    Witt, Adam [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Chalise, Dol Raj [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Hadjerioua, Boualem [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Manwaring, Michael [MWH, Broomfield, CO (United States); Bishop, Norm [Knight Piesold, Denver, CO (United States)

    2016-10-01

    The slow pace of Pumped Storage Hydropower development in the US over the past twenty years has led to widespread interest in the feasibility and viability of alternative PSH designs, development schemes, and technologies. Since 2011, Oak Ridge National Lab has been exploring the economic viability of modular Pumped Storage Hydropower (m-PSH) development through targeted case studies, revenue simulations, and analysis of innovative configurations and designs. This paper outlines the development and supporting analysis of a scalable, comprehensive cost modeling tool designed to simulate the initial capital costs for a variety of potential m-PSH projects and deployment scenarios. The tool is used to explore and determine innovative research strategies that can improve the economic viability of m-PSH in US markets.

  18. Effects of small hydropower plants on mercury concentrations in fish.

    Science.gov (United States)

    Cebalho, Elaine C; Díez, Sergi; Dos Santos Filho, Manoel; Muniz, Claumir Cesar; Lázaro, Wilkinson; Malm, Olaf; Ignácio, Aurea R A

    2017-10-01

    Although the impacts of large dams on freshwater biota are relatively well known, the effects of small hydropower plants (SHP) are not well investigated. In this work, we studied if mercury (Hg) concentrations in fish rise in two tropical SHP reservoirs, and whether similar effects take place during impoundment. Total Hg concentrations in several fish species were determined at two SHP in the Upper Guaporé River basin floodplain, Brazil. In total, 185 specimens were analysed for Hg content in dorsal muscle and none of them reported levels above the safety limit (500 μg kg -1 ) for fish consumption recommended by the World Health Organisation (WHO). The highest levels of Hg (231 and 447 μg kg -1 ) were found in carnivorous species in both reservoirs. Mercury increased as a function of standard length in most of the fish populations in the reservoirs, and higher Hg concentrations were found in fish at the reservoir compared with fish downstream. The high dissolved oxygen concentrations and high transparency of the water column (i.e. oligotrophic reservoir) together with the absence of thermal stratification may explain low Hg methylation and low MeHg levels found in fish after flooding. Overall, according to limnological characteristics of water, we may hypothesise that reservoir conditions are not favourable to high net Hg methylation.

  19. 2014 Hydropower Market Report

    Energy Technology Data Exchange (ETDEWEB)

    Rocío Uría-Martínez, Patrick W. O’Connor, Megan M. Johnson

    2015-04-30

    The U.S. hydropower fleet has been providing clean, reliable power for more than a hundred years. However, no systematic documentation exists of the U.S. fleet and the trends influencing it in recent years. This first-ever Hydropower Market Report seeks to fill this gap and provide industry and policy makers with a quantitative baseline on the distribution, capabilities, and status of hydropower in the United States.

  20. New and Unexpected Biological Functions for the Src-Homology 2 Domain-Containing Phosphatase SHP-2 in the Gastrointestinal TractSummary

    Directory of Open Access Journals (Sweden)

    Geneviève Coulombe

    2016-01-01

    Full Text Available SHP-2 is a tyrosine phosphatase expressed in most embryonic and adult tissues. SHP-2 regulates many cellular functions including growth, differentiation, migration, and survival. Genetic and biochemical evidence show that SHP-2 is required for rat sarcoma viral oncogene/extracellular signal-regulated kinases mitogen-activated protein kinase pathway activation by most tyrosine kinase receptors, as well as by G-protein–coupled and cytokine receptors. In addition, SHP-2 can regulate the Janus kinase/signal transducers and activators of transcription, nuclear factor-κB, phosphatidyl-inositol 3-kinase/Akt, RhoA, Hippo, and Wnt/β-catenin signaling pathways. Emerging evidence has shown that SHP-2 dysfunction represents a key factor in the pathogenesis of gastrointestinal diseases, in particular in chronic inflammation and cancer. Variations within the gene locus encoding SHP-2 have been associated with increased susceptibility to develop ulcerative colitis and gastric atrophy. Furthermore, mice with conditional deletion of SHP-2 in intestinal epithelial cells rapidly develop severe colitis. Similarly, hepatocyte-specific deletion of SHP-2 induces hepatic inflammation, resulting in regenerative hyperplasia and development of tumors in aged mice. However, the SHP-2 gene initially was suggested to be a proto-oncogene because activating mutations of this gene were found in pediatric leukemias and certain forms of liver and colon cancers. Moreover, SHP-2 expression is up-regulated in gastric and hepatocellular cancers. Notably, SHP-2 functions downstream of cytotoxin-associated antigen A (CagA, the major virulence factor of Helicobacter pylori, and is associated with increased risks of gastric cancer. Further compounding this complexity, most recent findings suggest that SHP-2 also coordinates carbohydrate, lipid, and bile acid synthesis in the liver and pancreas. This review aims to summarize current knowledge and recent data regarding the

  1. SHP-1 is a target of regorafenib in colorectal cancer

    Science.gov (United States)

    Lin, Hang; Hung, Man-Hsin; Chen, Yen-Lin; Huang, Jui-Wen; Tai, Wei-Tien; Yu, Hui-Chuan; Chen, Kuen-Feng

    2014-01-01

    Regorafenib is an inhibitor of multiple protein kinases which exerts antitumor and antimetastatic activities in metastatic colorectal cancer (CRC). SH2 domain-containing phosphatase 1 (SHP-1) is reported to have tumor suppressive potential because it acts as a negative regulator of p-STAT3Tyr705 signaling. However, little is known about the mechanism regarding regorafenib affects SHP-1 tyrosine phosphatase activity and leads to apoptosis and tumor suppression in CRC. Here, we found that regorafenib triggered apoptotic cell death and significantly enhanced SHP-1 activity, which dramatically decreased the phosphorylated form of STAT3 at Tyr705 (p-STAT3Tyr705). Importantly, regorafenib augmented SHP-1 activity by direct disruption of the association between N-SH2 and catalytic PTP domain of SHP-1. Deletion of the N-SH2 domain (dN1) or point mutation (D61A) of SHP-1 blocked the effect of regorafenib-induced SHP-1 activity, growth inhibition and a decrease of p-STAT3Tyr705 expression, suggesting that regorafenib triggers a conformational change in SHP-1 by relieving its autoinhibition. In vivo assay showed that regorafenib significantly inhibited xenograft growth and decreased p-STAT3Tyr705 expression but induced higher SHP-1 activity. Collectively, regorafenib is a novel SHP-1 agonist exerts superior anti-tumor effects by enhancing SHP-1 activity that directly targets p-STAT3Tyr705. Small molecule-enhancement of SHP-1 activity may be a promising therapeutic approach for CRC treatment. PMID:25071018

  2. Economic critique of Nam Theun-Hinboun Hydropower Project and electricity development in Laos: proposal for an alternative path to development

    International Nuclear Information System (INIS)

    Adams, T.

    1996-01-01

    A proposed alternative to the development of a large-scale hydropower project in Laos was presented. The alternative is intended to help make electricity development sustainable over the long term and to benefit the citizens of Laos. The author carefully analyzed the Asian Development Bank report RRP: Laos 27325 of October 1994. He concluded that as presently constituted, the project is likely to fail as an investment and is likely to result in a significant net financial liability. Water resources are one of Laos' greatest assets and the future uses of Laotian rivers could be lost in order to achieve near-term electricity development. It was suggested that Laos should follow three key principles in the development of its electricity sector: maximize economic efficiency, ensure that the government acts as a regulator and not as an investor, and ensure the protection of property rights of citizens and investors. Relevant aspects of the experience with electricity development in Canada were also outlined

  3. Beyond harm's reach? Submersion of river turtle nesting areas and implications for restoration actions after Amazon hydropower development.

    Science.gov (United States)

    Norris, Darren; Michalski, Fernanda; Gibbs, James P

    2018-01-01

    The global expansion of energy demands combined with abundant rainfall, large water volumes and high flow in tropical rivers have led to an unprecedented expansion of dam constructions in the Amazon. This expansion generates an urgent need for refined approaches to river management; specifically a move away from decision-making governed by overly generalized guidelines. For the first time we quantify direct impacts of hydropower reservoir establishment on an Amazon fresh water turtle. We conducted surveys along 150 km of rivers upstream of a new dam construction during the low water months that correspond to the nesting season of Podocnemis unifilis in the study area. Comparison of nest-areas before (2011, 2015) and after (2016) reservoir filling show that reservoir impacts extend 13% beyond legally defined limits. The submerged nesting areas accounted for a total of 3.8 ha of nesting habitat that was inundated as a direct result of the reservoir filling in 2016. Our findings highlight limitations in the development and implementation of existing Brazilian environmental impact assessment process. We also propose potential ways to mitigate the negative impacts of dams on freshwater turtles and the Amazonian freshwater ecosystems they inhabit.

  4. Beyond harm’s reach? Submersion of river turtle nesting areas and implications for restoration actions after Amazon hydropower development

    Science.gov (United States)

    Michalski, Fernanda; Gibbs, James P.

    2018-01-01

    The global expansion of energy demands combined with abundant rainfall, large water volumes and high flow in tropical rivers have led to an unprecedented expansion of dam constructions in the Amazon. This expansion generates an urgent need for refined approaches to river management; specifically a move away from decision-making governed by overly generalized guidelines. For the first time we quantify direct impacts of hydropower reservoir establishment on an Amazon fresh water turtle. We conducted surveys along 150 km of rivers upstream of a new dam construction during the low water months that correspond to the nesting season of Podocnemis unifilis in the study area. Comparison of nest-areas before (2011, 2015) and after (2016) reservoir filling show that reservoir impacts extend 13% beyond legally defined limits. The submerged nesting areas accounted for a total of 3.8 ha of nesting habitat that was inundated as a direct result of the reservoir filling in 2016. Our findings highlight limitations in the development and implementation of existing Brazilian environmental impact assessment process. We also propose potential ways to mitigate the negative impacts of dams on freshwater turtles and the Amazonian freshwater ecosystems they inhabit. PMID:29333347

  5. Mini and micro hydropower systems in India

    International Nuclear Information System (INIS)

    Kothari, D.P.

    1992-01-01

    Hydropower is one of the renewable sources of energy. In the field of hydropower, even though small/mini/micro hydropower systems make fractional increases in the overall energy production, their impact on the local areas in which they are sited can be significant in stimulating growth of rural industry and in meeting the basic energy needs of the local population for domestic and agricultural use. They also help in reducing demand on other non-renewable polluting resources like fossil fuels. Moreover as compared to big hydropower systems, small hydropower systems are cost competitive and minimally disruptive to the environment. They require less time for construction and reduce transmission losses. They can be designed to suit the limits of water resources available and can be tailored to the needs of the end-use market. Aspects of small hydropower projects which needs to be studied are listed. Modelling of turbines and generators for such projects, and factors to be considered in selection of suitable turbine and generator for a particular small hydropower system are discussed. The technology for small hydropower systems is well developed and available in India. The present estimated potential of such systems in India is 5000 MW out of which 207 MW is harnessed. These small hydropower plants are mostly located in the northern states like Jammu and Kashmir, Uttar Pradesh, Punjab, and Rajasthan. Construction works for 234 MW at 88 sites are going on. During the 8th plan period, 218.5 MW is planned to be developed with an outlay of Rs. 548.25 crores. It is suggested that special subsidies and liberal term loans should be made available for implementing such systems. (M.G.B.). 8 refs., 2 tabs., 1 fig

  6. China's rising hydropower demand challenges water sector.

    Science.gov (United States)

    Liu, Junguo; Zhao, Dandan; Gerbens-Leenes, P W; Guan, Dabo

    2015-07-09

    Demand for hydropower is increasing, yet the water footprints (WFs) of reservoirs and hydropower, and their contributions to water scarcity, are poorly understood. Here, we calculate reservoir WFs (freshwater that evaporates from reservoirs) and hydropower WFs (the WF of hydroelectricity) in China based on data from 875 representative reservoirs (209 with power plants). In 2010, the reservoir WF totaled 27.9 × 10(9) m(3) (Gm(3)), or 22% of China's total water consumption. Ignoring the reservoir WF seriously underestimates human water appropriation. The reservoir WF associated with industrial, domestic and agricultural WFs caused water scarcity in 6 of the 10 major Chinese river basins from 2 to 12 months annually. The hydropower WF was 6.6 Gm(3) yr(-1) or 3.6 m(3) of water to produce a GJ (10(9) J) of electricity. Hydropower is a water intensive energy carrier. As a response to global climate change, the Chinese government has promoted a further increase in hydropower energy by 70% by 2020 compared to 2012. This energy policy imposes pressure on available freshwater resources and increases water scarcity. The water-energy nexus requires strategic and coordinated implementations of hydropower development among geographical regions, as well as trade-off analysis between rising energy demand and water use sustainability.

  7. Longtan hydropower project and the financial constraints

    International Nuclear Information System (INIS)

    Ding Zhao.

    1995-01-01

    China has large untapped resources of hydropower, including such schemes as the Longtan project on the Hongshui river. Despite the attractiveness of the resource and China's need for power, development of these projects is constrained by financial problems. (Author)

  8. Hydropower annual report 2003

    Energy Technology Data Exchange (ETDEWEB)

    Cada, Glenn F. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Carlson, Thomas J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dauble, Dennis D. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hunt, Richard T. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Idaho National Engineering Lab. (INEL); Sale, Michael J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sommers, Garold L. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Idaho National Engineering Lab. (INEL)

    2004-02-01

    This report describes hydropower activities supported by the U.S. Department of Energy (DOE) Wind and Hydropower Program during Fiscal Year 2003 (October 1, 2002 to September 30, 2003). Background on the program, FY03 accomplishments, and future plans are presented in the following sections.

  9. Hydropower Modeling Challenges

    Energy Technology Data Exchange (ETDEWEB)

    Stoll, Brady [National Renewable Energy Lab. (NREL), Golden, CO (United States); Andrade, Juan [National Renewable Energy Lab. (NREL), Golden, CO (United States); Cohen, Stuart [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brinkman, Greg [National Renewable Energy Lab. (NREL), Golden, CO (United States); Brancucci Martinez-Anido, Carlo [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-04-19

    Hydropower facilities are important assets for the electric power sector and represent a key source of flexibility for electric grids with large amounts of variable generation. As variable renewable generation sources expand, understanding the capabilities and limitations of the flexibility from hydropower resources is important for grid planning. Appropriately modeling these resources, however, is difficult because of the wide variety of constraints these plants face that other generators do not. These constraints can be broadly categorized as environmental, operational, and regulatory. This report highlights several key issues involving incorporating these constraints when modeling hydropower operations in terms of production cost and capacity expansion. Many of these challenges involve a lack of data to adequately represent the constraints or issues of model complexity and run time. We present several potential methods for improving the accuracy of hydropower representation in these models to allow for a better understanding of hydropower's capabilities.

  10. Study of the potential of carbon credits to SHP CDM projects based on evolution of installed capacity (2010 - 2019); Estudo do potencial de receitas decorrentes de creditos de carbono provenientes de projetos de MDL para PCHs com base na evolucao da potencia instalada (2010 - 2019)

    Energy Technology Data Exchange (ETDEWEB)

    Pieroni, Marcela Fernandes [Centro Nacional de Referencia em Pequenas Centrais Hidreletricas (CERPCH/UNIFEI), Itajuba, MG (Brazil); Barros, Regina Mambeli; Tiago Filho, Geraldo Lucio [Universidade Federal de Itajuba (IRN/UNIFEI), MG (Brazil). Inst. de Recursos Naturais

    2011-01-15

    This study aims to assess the generation of carbon credits from projects under the clean development mechanism of small hydropower (SHP), based on studies of the evolution of installed capacity for these new developments over the next nine years. For this reason, two hypotheses and two scenarios were considered in order to better represent the reality of revenue generation over the years. The first hypothesis considers the development of small hydro power installed according to the Ten Year Plan for Expansion of Energy 2019. The second hypothesis considers the study of Tiago Filho, Barros e Silva (2009) about growth of installed capacity based on the gross national product (GNP). The simulation of revenues from carbon credits was done using the spreadsheet in Microsoft Excel for Michellis Jr (2010). The results showed that the forecast of growth of SHP performed based on GNP (hypothesis 1) is more conservative, thus leading to a lower potential of carbon credits, about 4.113.957 tCO{sub 2} avoided. Already the results of hypothesis 2 showed a total of 3.247.717 tCO{sub 2} avoided. (author)

  11. Development and practical testing of an action plan for the environmentally compatible use of hydropower; Erarbeitung und Praxiserprobung eines Massnahmenplanes zur oekologisch vertraeglichen Wasserkraftnutzung

    Energy Technology Data Exchange (ETDEWEB)

    Keuneke, Rita; Dumont, Ulrich [Ingenieurbuero Floecksmuehle, Aachen (Germany)

    2011-05-15

    The use of rivers for generating electric power and the efforts to conserve important ecological habitats mark a classic conflict between two different aims of society. While passing hydropower plants migrating fish risk injuries and death. This affects the development of fish populations, particularly of diadromous fish populations in river basins. The aim of this study was to find conditions for serving a self sustaining fish population in the Weser basin. The influence of the river continuity and the quality of spawning and nursery habitats were varied. The survival rates of the diadromous species salmon and eel were modeled on the basis of literature data and additional data from own investigations. A self-reproducing salmon population would require the upstream and downstream passibility at each obstacle. Especially the protection at hydropower plants in the tributaries is of major importance. In addition, the hydro-morphological conditions of the spawning habitats have to be improved and further losses (such as predation or fishing) must be decreased. The survival rate of 40%, required by the EC Regulation on European eel can be achieved by the establishment of upstream continuity at all sites and by protective measures at the hydropower plants in the tributaries of the Weser. (orig.)

  12. The PTPN11 loss-of-function mutation Q510E-Shp2 causes hypertrophic cardiomyopathy by dysregulating mTOR signaling.

    Science.gov (United States)

    Schramm, Christine; Fine, Deborah M; Edwards, Michelle A; Reeb, Ashley N; Krenz, Maike

    2012-01-01

    The identification of mutations in PTPN11 (encoding the protein tyrosine phosphatase Shp2) in families with congenital heart disease has facilitated mechanistic studies of various cardiovascular defects. However, the roles of normal and mutant Shp2 in the developing heart are still poorly understood. Furthermore, it remains unclear how Shp2 loss-of-function (LOF) mutations cause LEOPARD Syndrome (also termed Noonan Syndrome with multiple lentigines), which is characterized by congenital heart defects such as pulmonary valve stenosis and hypertrophic cardiomyopathy (HCM). In normal hearts, Shp2 controls cardiomyocyte size by regulating signaling through protein kinase B (Akt) and mammalian target of rapamycin (mTOR). We hypothesized that Shp2 LOF mutations dysregulate this pathway, resulting in HCM. For our studies, we chose the Shp2 mutation Q510E, a dominant-negative LOF mutation associated with severe early onset HCM. Newborn mice with cardiomyocyte-specific overexpression of Q510E-Shp2 starting before birth displayed increased cardiomyocyte sizes, heart-to-body weight ratios, interventricular septum thickness, and cardiomyocyte disarray. In 3-mo-old hearts, interstitial fibrosis was detected. Echocardiographically, ventricular walls were thickened and contractile function was depressed. In ventricular tissue samples, signaling through Akt/mTOR was hyperactivated, indicating that the presence of Q510E-Shp2 led to upregulation of this pathway. Importantly, rapamycin treatment started shortly after birth rescued the Q510E-Shp2-induced phenotype in vivo. If rapamycin was started at 6 wk of age, HCM was also ameliorated. We also generated a second mouse model in which cardiomyocyte-specific Q510E-Shp2 overexpression started after birth. In contrast to the first model, these mice did not develop HCM. In summary, our studies establish a role for mTOR signaling in HCM caused by Q510E-Shp2. Q510E-Shp2 overexpression in the cardiomyocyte population alone was sufficient to

  13. Hydropower's role in delivering sustainability

    International Nuclear Information System (INIS)

    Altinbilek, D.; Seelos, K.; Taylor, R.

    2005-01-01

    Johannesburg's World Summit on Sustainable Development stipulated in its Implementation Plan that hydropower of all scales should be included in the drive to increase the contribution of renewable energy. This can be achieved through the plant-life extension and upgrading of existing schemes as well as by the sustainable development of new projects according to the needs, opportunities and resources available. Hydropower is the world's largest source of renewable energy used for power generation; it accounts for 19 percent of the world's supply (by 2010 wind power is expected to contribute 0.6 percent and solar power 0.12 percent. Hydropower is also a truly global resource, as more than 150 countries generate hydroelectric power. There is about 730 GW of hydro capacity in operation worldwide, generating 2650 TWh/year. A further 101 GW is under construction and 338 GW is at the planning stage. Hydropower plays an important role in reducing global GhG emissions by an estimated 10 percent per annum; in its current role, hydropower offsets 4.4 million barrels of oil-equivalent (thermal electric generation) each day. There is vast unexploited potential worldwide for new hydro plants, with only 33 percent of the economic potential having been developed so far. The majority of the remaining potential exists in lesser developed countries in Asia, South America and Africa. For example, Europe has developed 75 percent of its economic potential, whereas Africa has only developed seven percent. Hydropower technologies are reliable, advanced and efficient. The energy conversion efficiency of 80 to 93 percent is far higher than that for other major types of power plant. The level of service from the various types of hydro scheme varies from base-load supply, typically from run-of-river schemes, to peak-load and system-back-up services from hydro storage schemes. In regions where there is long-developed hydro capacity, plant-life extension can be achieved by the replacement of

  14. Hydropower Vision: Full Report

    Energy Technology Data Exchange (ETDEWEB)

    None, None

    2016-07-01

    Hydropower has provided clean, affordable, reliable, and renewable electricity in the United States for more than a century. Building on hydropower’s historical significance, and to inform the continued technical evolution, energy market value, and environmental performance of the industry, the U.S. Department of Energy’s (DOE’s) Wind and Water Power Technologies Office has led a first-of-its-kind comprehensive analysis focused on a set of potential pathways for the environmentally sustainable expansion of hydropower (hydropower generation and pumped storage) in the United States.

  15. Department of Energy Small-Scale Hydropower Program: Feasibility assessment and technology development summary report

    International Nuclear Information System (INIS)

    Rinehart, B.N.

    1991-06-01

    This report summarizes two subprograms under the US Department of Energy's Small-Scale Hydroelectric Power Program. These subprograms were part of the financial assistance activities and included the Program Research and Development Announcement (PRDA) feasibility assessments and the technology development projects. The other major subprograms included engineering research and development, legal and institutional aspects, and technology transfer. These other subprograms are covered in their respective summary reports. The problems of energy availability and increasing costs of energy led to a national effort to develop economical and environmental attractive alternative energy resources. One such alternative involved the utilization of existing dams with hydraulic heads of <65 ft and the capacity to generate hydroelectric power of 15 MW or less. Thus, the PRDA program was initiated along with the Technology Development program. The purpose of the PRDA feasibility studies was to encourage development of renewable hydroelectric resources by providing engineering, economic, environmental, safety, and institutional information. Fifty-five feasibility studies were completed under the PRDA. This report briefly summarizes each of those projects. Many of the PRDA projects went on to become technology development projects. 56 refs., 1 fig., 2 tabs

  16. Department of Energy Small-Scale Hydropower Program: Feasibility assessment and technology development summary report

    Energy Technology Data Exchange (ETDEWEB)

    Rinehart, B.N.

    1991-06-01

    This report summarizes two subprograms under the US Department of Energy's Small-Scale Hydroelectric Power Program. These subprograms were part of the financial assistance activities and included the Program Research and Development Announcement (PRDA) feasibility assessments and the technology development projects. The other major subprograms included engineering research and development, legal and institutional aspects, and technology transfer. These other subprograms are covered in their respective summary reports. The problems of energy availability and increasing costs of energy led to a national effort to develop economical and environmental attractive alternative energy resources. One such alternative involved the utilization of existing dams with hydraulic heads of <65 ft and the capacity to generate hydroelectric power of 15 MW or less. Thus, the PRDA program was initiated along with the Technology Development program. The purpose of the PRDA feasibility studies was to encourage development of renewable hydroelectric resources by providing engineering, economic, environmental, safety, and institutional information. Fifty-five feasibility studies were completed under the PRDA. This report briefly summarizes each of those projects. Many of the PRDA projects went on to become technology development projects. 56 refs., 1 fig., 2 tabs.

  17. Water Grabbing in the Mekong Basin – An Analysis of the Winners and Losers of Thailand’s Hydropower Development in Lao PDR

    Directory of Open Access Journals (Sweden)

    Nathanial Matthews

    2012-06-01

    The analysis shows that the structure and politics of the Thai electricity sector, private-sector profiteering and a strong domestic civil society are driving Thailand’s hydropower investment in neighbouring Laos. Thai investments are enabled by Laos’ weak enforcement of laws, a lack of capacity to regulate development, the existence of corruption and a tightly controlled state. These drivers and enabling factors combine with short-term economic focused regional development to create opportunities for water grabbing. The winners of this water grabbing are the powerful actors who control the benefits, while the losers, local livelihoods and the environment, are negatively impacted.

  18. Development and Climate Change in Nepal. Focus on Water Resources and Hydropower

    International Nuclear Information System (INIS)

    Agrawala, S.; Raksakulthai, V.; Van Aalst, M.; Larsen, P.; Smith, J.; Reynolds, J.

    2003-01-01

    This document is an output from the OECD Development and Climate Change project, an activity jointly overseen by the EPOC Working Party on Global and Structural Policies (WPGSP), and the DAC Network on Environment and Development Co-operation (ENVIRONET). The overall objective of the project is to provide guidance on how to mainstream responses to climate change within economic development planning and assistance policies, with natural resource management as an overarching theme. This report presents the integrated case study for Nepal carried out under an OECD project on Development and Climate Change. The report is structured around a three-tier framework. First, recent climate trends and climate change scenarios for Nepal are assessed, and key sectoral impacts are identified and ranked along multiple indicators to establish priorities for adaptation. Second, donor portfolios in Nepal are analyzed to examine the proportion of donor activities affected by climate risks. A desk analysis of donor strategies and project documents as well as national plans is conducted to assess the degree of attention to climate change concerns in development planning and assistance. Third, an in-depth analysis is conducted for Nepal's water resources sector which was identified as most vulnerable to climate change. This part of the analysis also involved stakeholder consultation through an in-country workshop to identify key synergies and conflicts between climate change concerns and sectoral projects and plans

  19. Hydromorphological conditions of the lower Vistula in the development of navigation and hydropower

    Directory of Open Access Journals (Sweden)

    Zygmunt Babiński

    2013-06-01

    Full Text Available The article presents general principles of development of the lower Vistula channel in the Holocene period, with a particular emphasis on the unintentional human interference in the fluvial processes associated with deforestation and cultivation of cereals and root crops. It also characterises the basic hydraulic engineering works in the form of construction of embankments, adjustment of the bed and construction of the Włocławek barrage as factors of deliberate human interference and their impact on channel changes. The article characterises morphological and morphodynamic conditions of the basic bed forms, i.e. sandy and gravel bars and pools determining the possibility of river transport, and its development in time and space (depth of navigable route. Perspectives of multi-directional hydraulic development are presented, including the main cascade developments of the lower Vistula. The article presents the opportunities for a comprehensive use of the waterway, which forms route E40 in the section of the lower Vistula, taking into account sustainable development and compensation in the form of restoration of the valley bottom.

  20. Ecological footprint analysis of environmental impacts by cascaded exploitation of diversion-type small hydropower: a case study in southwest china

    Science.gov (United States)

    Wang, Zhenhua; Li, Qingyun; Huang, Zhuo; Tang, Xianqiang; Zhao, Weihua

    2017-05-01

    Cascaded exploitation of diversion-type small hydropower (SHP) offers a source of new energy as well as socioeconomic benefits; however, it inevitably causes environmental disturbance and damage. Previous studies on the cumulative effect of cascaded diversion SHP rarely discussed using quantitative analysis method. In this paper, the ecological footprint analysis approach is proposed to assess the positive and negative impacts of cascaded diversion SHP on environment of a small-scale river in Southwest China. Positive impact is defined as ecological supply footprint (ESF), which refers to vegetation protection by replacing firewood with SHP. Negative impact is defined as ecological loss footprint (ELF), which includes fish and net primary productivity loss, vegetation destruction and soil erosion. With the raising in the number (n>4) of diversion SHP stations, the difference between ELF and ESF increases remarkably, suggesting that the adverse impacts of cascaded diversion SHP accumulate in the study area. Compared with vegetation destruction and soil erosion, the cumulative loss of fish and net productivity is the most important aspect of the adverse impacts which needs more attentions.

  1. Corporate Social Responsibility: Benefits for Youth in Hydropower Development in Laos

    Science.gov (United States)

    Sparkes, Stephen

    2014-01-01

    The role of the state as regulator combined with policies on Corporate Social Responsibility (CSR) that go beyond legal requirements to establishing programmes that promote development and good international business practice is an emerging new paradigm. In this paper, the example of a state-owned company, Statkraft A.S. of Norway, and its recent…

  2. Development of a more fish-tolerant turbine runner, advanced hydropower turbine project

    International Nuclear Information System (INIS)

    Cook, T.C.; Hecker, G.E.

    1997-02-01

    Alden Research Laboratory, Inc. (ARL) and Northern Research and Engineering Corporation (NREC) conducted a research program to develop a turbine runner which will minimize fish injury and mortality at hydroelectric projects. ARL?NREC have developed a runner shape which minimizes the number of blade leading edges, reduces the pressure versus time and the velocity versus distance gradients within the runner, minimizes or eliminates the clearance between the runner and runner housing, and maximizes the size of the flow passages, all with minimal penalty on turbine efficiency. An existing pump impeller provided the starting point for developing the fish tolerant turbine runner. The Hidrostal pump is a single bladed combined screw/centrifugal pump which has been proven to transport fish with minimal injury. The focus of the ARL/NREC research project was to develop a new runner geometry which is effective in downstream fish passage and hydroelectric power generation. A flow of 1,000 cfs and a head in the range of 75 ft to 100 ft were selected for conceptual design of the new runner. Conceptual design of the new runner began with a re-evaluation of studies which have been previously conducted to identify probable sources of injury to fish passing through hydraulic turbines. Criteria relative to hydraulic characteristics which are favorable for fish passage were prepared based on a reassessment of the available information. Important criteria used to develop the new runner design included low pressure change rates, minimum absolute pressures, and minimum shear. Other criteria which are reflected in the runner design are a minimum number of blades (only two), minimum total length of leading edges, and large flow passages. 86 figs., 5 tabs

  3. Hydropower strategy for the Philippines

    International Nuclear Information System (INIS)

    McCandless, D.H.

    1995-01-01

    The government-owned National Power Corporation (NPC) of the Philippines is in the early stages of a complete privatisation programme. The electric power sector is expected eventually to be structured around a company that will own the major transmission facilities and will serve as a broker of power and energy between generating companies and the existing distribution companies, Rural Electric Co-operations and other power users. NPC's non-transmission assets will probably be spun-off into various corporations including three generating companies, an engineering and services company and a company owning the Calivaya-Botocan-Kalayaan hydro complex. Plans for increased capacity include a real term increase in the hydropower contribution although it will decline as a percentage of the energy mix as coal and gas plants are developed. Details of the privatisation of specific hydropower projects in the Luzon, Visayas and Mindanao grids are described. (U.K.)

  4. Development and modelisation of a hydro-power conversion system based on vortex induced vibration

    Science.gov (United States)

    Lefebure, David; Dellinger, Nicolas; François, Pierre; Mosé, Robert

    2016-11-01

    The Vortex Induced Vibration (VIV) phenomenon leads to mechanical issues concerning bluff bodies immerged in fluid flows and have therefore been studied by numerous authors. Moreover, an increasing demand for energy implies the development of alternative, complementary and renewable energy solutions. The main idea of EauVIV project consists in the use of VIV rather than its deletion. When rounded objects are immerged in a fluid flow, vortices are formed and shed on their downstream side, creating a pressure imbalance resulting in an oscillatory lift. A convertor modulus consists of an elastically mounted, rigid cylinder on end-springs, undergoing flow- induced motion when exposed to transverse fluid-flow. These vortices induce cyclic lift forces in opposite directions on the circular bar and cause the cylinder to vibrate up and down. An experimental prototype was developed and tested in a free-surface water channel and is already able to recover energy from free-stream velocity between 0.5 and 1 m.s -1. However, the large number of parameters (stiffness, damping coefficient, velocity of fluid flow, etc.) associated with its performances requires optimization and we choose to develop a complete tridimensionnal numerical model solution. A 3D numerical model has been developed in order to represent the real system behavior and improve it through, for example, the addition of parallel cylinders. The numerical model build up was carried out in three phases. The first phase consists in establishing a 2D model to choose the turbulence model and quantify the dependence of the oscillations amplitudes on the mesh size. The second corresponds to a 3D simulation with cylinder at rest in first time and with vertical oscillation in a second time. The third and final phase consists in a comparison between the experimental system dynamic behavior and its numerical model.

  5. Fish-Friendly Hydropower Turbine Development & Deployment: Alden Turbine Preliminary Engineering and Model Testing

    Energy Technology Data Exchange (ETDEWEB)

    Foust, J. [Voith Hydro, Inc., York, PA (USA); Hecker, G. [Alden Research Laboratory, Inc., Holden, MA (USA); Li, S. [Alden Research Laboratory, Inc., Holden, MA (USA); Allen, G. [Alden Research Laboratory, Inc., Holden, MA (USA)

    2011-10-01

    The Alden turbine was developed through the U.S. Department of Energy's (DOE's) former Advanced Hydro Turbine Systems Program (1994-2006) and, more recently, through the Electric Power Research Institute (EPRI) and the DOE's Wind & Water Power Program. The primary goal of the engineering study described here was to provide a commercially competitive turbine design that would yield fish passage survival rates comparable to or better than the survival rates of bypassing or spilling flow. Although the turbine design was performed for site conditions corresponding to 92 ft (28 m) net head and a discharge of 1500 cfs (42.5 cms), the design can be modified for additional sites with differing operating conditions. During the turbine development, design modifications were identified for the spiral case, distributor (stay vanes and wicket gates), runner, and draft tube to improve turbine performance while maintaining features for high fish passage survival. Computational results for pressure change rates and shear within the runner passage were similar in the original and final turbine geometries, while predicted minimum pressures were higher for the final turbine. The final turbine geometry and resulting flow environments are expected to further enhance the fish passage characteristics of the turbine. Computational results for the final design were shown to improve turbine efficiencies by over 6% at the selected operating condition when compared to the original concept. Prior to the release of the hydraulic components for model fabrication, finite element analysis calculations were conducted for the stay vanes, wicket gates, and runner to verify that structural design criteria for stress and deflections were met. A physical model of the turbine was manufactured and tested with data collected for power and efficiency, cavitation limits, runaway speed, axial and radial thrust, pressure pulsations, and wicket gate torque. All parameters were observed to fall

  6. Identifying Impacts of Hydropower Regulation on Salmonid Habitats to Guide River Restoration for Existing Schemes and Mitigate Adverse Effects of Future Developments

    Science.gov (United States)

    Buddendorf, B.; Geris, J.; Malcolm, I.; Wilkinson, M.; Soulsby, C.

    2015-12-01

    A decrease in longitudinal connectivity in riverine ecosystems resulting from the construction of transverse barriers has been identified as a major threat to biodiversity. For example, Atlantic Salmon (Salmo salar) have a seasonal variety of hydraulic habitat requirements for their different life stages. However, hydropower impoundments impact the spatial and temporal connectivity of natural habitat along many salmon rivers in ways that are not fully understood. Yet, these changes may affect the sustainability of habitat at local and regional scales and so ultimately the conservation of the species. Research is therefore needed both to aid the restoration and management of rivers impacted by previous hydropower development and guide new schemes to mitigate potentially adverse effects. To this end we assessed the effects of hydropower development on the flow related habitat conditions for different salmon life stages in Scottish rivers at different spatial scales. We used GIS techniques to map the changes in structural connectivity at regional scales, applying a weighting for habitat quality. Next, we used hydrological models to simulate past and present hydrologic conditions that in turn drive reach-scale hydraulic models to assess the impacts of regulation on habitat suitability in both space and time. Preliminary results indicate that: 1) impacts on connectivity depend on the location of the barrier within the river network; 2) multiple smaller barriers may have a potentially lower impact than a single larger barrier; 3) there is a relationship between habitat and connectivity where losing less but more suitable habitat potentially has a disproportionally large impact; 4) the impact of flow regulation can lead to a deterioration of habitat quality, though the effects are spatially variable and the extent of the impact depends on salmon life stage. This work can form a basis for using natural processes to perform targeted and cost-effective restoration of rivers.

  7. Uncertainties in Amazon Hydropower Development: Risk Scenarios and Environmental Issues around the Belo Monte Dam

    Directory of Open Access Journals (Sweden)

    Wilson Cabral de Sousa Júnior

    2010-06-01

    Full Text Available The Amazon region is the final frontier and central focus of Brazilian hydro development, which raises a range of environmental concerns. The largest project in the Amazon is the planned Belo Monte Complex on the Xingu river. If constructed it will be the second biggest hydroelectric plant in Brazil, third largest on earth. In this study, we analyse the private and social costs, and benefits of the Belo Monte project. Furthermore, we present risk scenarios, considering fluctuations in the project’s feasibility that would result from variations in total costs and power. For our analysis, we create three scenarios. In the first scenario Belo Monte appears feasible, with a net present value (NPV in the range of US$670 million and a rate of return in excess of the 12% discount rate used in this analysis. The second scenario, where we varied some of the project costs and assumptions based on other economic estimates, shows the project to be infeasible, with a negative NPV of about US$3 billion and external costs around US$330 million. We also conducted a risk analysis, allowing variation in several of the parameters most important to the project’s feasibility. The simulations brought together the risks of cost overruns, construction delays, lower-than-expected generation and rising social costs. The probability of a positive NPV in these circumstances was calculated to be just 28%, or there is a 72% chance that the costs of the Belo Monte dam will be greater than the benefits. Several WCD recommendations are not considered in the project, especially those related to transparency, social participation in the discussion, economic analysis and risk assessment, and licensing of the project. This study underscores the importance of forming a participatory consensus, based on clear, objective information, on whether or not to build the Belo Monte dam.

  8. Gain-of-function mutations in the gene encoding the tyrosine phosphatase SHP2 induce hydrocephalus in a catalytically dependent manner.

    Science.gov (United States)

    Zheng, Hong; Yu, Wen-Mei; Waclaw, Ronald R; Kontaridis, Maria I; Neel, Benjamin G; Qu, Cheng-Kui

    2018-03-20

    Catalytically activating mutations in Ptpn11 , which encodes the protein tyrosine phosphatase SHP2, cause 50% of Noonan syndrome (NS) cases, whereas inactivating mutations in Ptpn11 are responsible for nearly all cases of the similar, but distinct, developmental disorder Noonan syndrome with multiple lentigines (NSML; formerly called LEOPARD syndrome). However, both types of disease mutations are gain-of-function mutations because they cause SHP2 to constitutively adopt an open conformation. We found that the catalytic activity of SHP2 was required for the pathogenic effects of gain-of-function, disease-associated mutations on the development of hydrocephalus in the mouse. Targeted pan-neuronal knockin of a Ptpn11 allele encoding the active SHP2 E76K mutant resulted in hydrocephalus due to aberrant development of ependymal cells and their cilia. These pathogenic effects of the E76K mutation were suppressed by the additional mutation C459S, which abolished the catalytic activity of SHP2. Moreover, ependymal cells in NSML mice bearing the inactive SHP2 mutant Y279C were also unaffected. Mechanistically, the SHP2 E76K mutant induced developmental defects in ependymal cells by enhancing dephosphorylation and inhibition of the transcription activator STAT3. Whereas STAT3 activity was reduced in Ptpn11 E76K/+ cells, the activities of the kinases ERK and AKT were enhanced, and neural cell-specific Stat3 knockout mice also manifested developmental defects in ependymal cells and cilia. These genetic and biochemical data demonstrate a catalytic-dependent role of SHP2 gain-of-function disease mutants in the pathogenesis of hydrocephalus. Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.

  9. Small hydropower for rural electrification in South Africa - using experiences from other African countries

    CSIR Research Space (South Africa)

    Jonker Klunne, WE

    2009-10-01

    Full Text Available Local hydropower sources can play an important role in the electrification of rural areas in South Africa remote from the national electricity grid. To ensure the sustainability of hydropower developments it is essential that lessons learned...

  10. Estimating Sediment Delivery to The Rio Maranon, Peru Prior to Large-Scale Hydropower Developments Using High Resolution Imagery from Google Earth and a DJI Phantom 3 Drone

    Science.gov (United States)

    Goode, J. R.; Candelaria, T.; Kramer, N. R.; Hill, A. F.

    2016-12-01

    As global energy demands increase, generating hydroelectric power by constructing dams and reservoirs on large river systems is increasingly seen as a renewable alternative to fossil fuels, especially in emerging economies. Many large-scale hydropower projects are located in steep mountainous terrain, where environmental factors have the potential to conspire against the sustainability and success of such projects. As reservoir storage capacity decreases when sediment builds up behind dams, high sediment yields can limit project life expectancy and overall hydropower viability. In addition, episodically delivered sediment from landslides can make quantifying sediment loads difficult. These factors, combined with remote access, limit the critical data needed to effectively evaluate development decisions. In the summer of 2015, we conducted a basic survey to characterize the geomorphology, hydrology and ecology of 620 km of the Rio Maranon, Peru - a major tributary to the Amazon River, which flows north from the semi-arid Peruvian Andes - prior to its dissection by several large hydropower dams. Here we present one component of this larger study: a first order analysis of potential sediment inputs to the Rio Maranon, Peru. To evaluate sediment delivery and storage in this system, we used high resolution Google Earth imagery to delineate landslides, combined with high resolution imagery from a DJI Phantom 3 Drone, flown at alluvial fan inputs to the river in the field. Because hillslope-derived sediment inputs from headwater tributaries are important to overall ecosystem health in large river systems, our study has the potential to contribute to the understanding the impacts of large Andean dams on sediment connectivity to the Amazon basin.

  11. The SHP's environmental licensing and the social communication: case study analysis of Funil and Carangola; O licenciamento ambiental de PCH e a comunicacao social: analise dos estudos de caso de Funil e Carangola

    Energy Technology Data Exchange (ETDEWEB)

    Galhardo, Camila Rocha

    2007-07-01

    Lately, concepts and paradigms have gone through constant alterations, due to high-speed growth the globe faces the dilemma of how to keep this growing and guarantee the survival conditions for next generations. Consequently, it comes into view the requirement for the discussion towards environment preservation and sustainability. In addition to this, humanity has been seeking for solutions to this impasse and the Brazilian Electric Sector equally has looked for alternatives since the beginning of electrification in the country, in early 19{sup th} Century, when the first Small Hydropower Plants (SHPs) were installed to provide energy to the industrial development period. Moreover, at present, this same category of energy generation plant represents a good opportunity, for the reason that they are framed as one of the sources of energy that is considered renewable or less pollutant. In the past years, technological evolution has been accompanied by the national industry of equipment and also the environmental legislation has created tools to mitigate the impacts of a Small Hydroelectric Plants (SHPs). The present research has aimed not only to present in its bibliographical revision the evolution of SHPs concept associated with the environmental aspects but also the application of techniques of social communication in the environmental license process. Furthermore it has looked for new communicative applicable tools in search of a larger public participation among the involved players, which results in important premises for the sustainability course of action. In order to attend those goals, two processes of SHP licensing were analyzed in Minas Gerais State, with main focus in the included Social Communication Program in the Plan of Environmental Control foreseen by the resolution number 006/87 of CONAMA (National Environmental Council). Finally, this research intended to present communicative feasible tools in the dimensioning of the participating actions in the

  12. The SHP's environmental licensing and the social communication: case study analysis of Funil and Carangola; O licenciamento ambiental de PCH e a comunicacao social: analise dos estudos de caso de Funil e Carangola

    Energy Technology Data Exchange (ETDEWEB)

    Galhardo, Camila Rocha

    2007-07-01

    Lately, concepts and paradigms have gone through constant alterations, due to high-speed growth the globe faces the dilemma of how to keep this growing and guarantee the survival conditions for next generations. Consequently, it comes into view the requirement for the discussion towards environment preservation and sustainability. In addition to this, humanity has been seeking for solutions to this impasse and the Brazilian Electric Sector equally has looked for alternatives since the beginning of electrification in the country, in early 19{sup th} Century, when the first Small Hydropower Plants (SHPs) were installed to provide energy to the industrial development period. Moreover, at present, this same category of energy generation plant represents a good opportunity, for the reason that they are framed as one of the sources of energy that is considered renewable or less pollutant. In the past years, technological evolution has been accompanied by the national industry of equipment and also the environmental legislation has created tools to mitigate the impacts of a Small Hydroelectric Plants (SHPs). The present research has aimed not only to present in its bibliographical revision the evolution of SHPs concept associated with the environmental aspects but also the application of techniques of social communication in the environmental license process. Furthermore it has looked for new communicative applicable tools in search of a larger public participation among the involved players, which results in important premises for the sustainability course of action. In order to attend those goals, two processes of SHP licensing were analyzed in Minas Gerais State, with main focus in the included Social Communication Program in the Plan of Environmental Control foreseen by the resolution number 006/87 of CONAMA (National Environmental Council). Finally, this research intended to present communicative feasible tools in the dimensioning of the participating actions in the

  13. Lack of Phosphotyrosine Phosphatase SHP-1 Expression in Malignant T-Cell Lymphoma Cells Results from Methylation of the SHP-1 Promoter

    DEFF Research Database (Denmark)

    Zhang, Q; Raghunath, P N; Vonderheid, E

    2000-01-01

    SHP-1 is an important negative regulator of signaling by several receptors including receptors for interleukin-2 (IL-2R) and other cytokines. SHP-1 acts by dephosphorylating the receptors and receptor-associated kinases such as IL-2R-associated Jak3 kinase. We found that SHP-1 protein was not det...

  14. U.S. hydropower resource assessment for Nevada

    Energy Technology Data Exchange (ETDEWEB)

    Conner, A.M.; Francfort, J.E.

    1997-10-01

    The US Department of Energy is developing an estimate of the undeveloped hydropower potential in the US. The Hydropower Evaluation Software (HES) is a computer model that was developed by the Idaho National Engineering Laboratory for this purpose. HES measures the undeveloped hydropower resources available in the US, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a menu-driven program that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report describes the resource assessment results for the State of Nevada.

  15. U.S. hydropower resource assessment for Idaho

    Energy Technology Data Exchange (ETDEWEB)

    Conner, A.M.; Francfort, J.E.

    1998-08-01

    The US Department of Energy is developing an estimate of the undeveloped hydropower potential in the US. The Hydropower Evaluation Software (HES) is a computer model that was developed by the Idaho National Engineering and Environmental Laboratory for this purpose. HES measures the undeveloped hydropower resources available in the US, using uniform criteria for measurement. The software was developed and tested using hydropower information and data provided by the Southwestern Power Administration. It is a menu-driven program that allows the personal computer user to assign environmental attributes to potential hydropower sites, calculate development suitability factors for each site based on the environmental attributes present, and generate reports based on these suitability factors. This report describes the resource assessment results for the State of Idaho.

  16. LEOPARD syndrome-associated SHP2 mutation confers leanness and protection from diet-induced obesity.

    Science.gov (United States)

    Tajan, Mylène; Batut, Aurélie; Cadoudal, Thomas; Deleruyelle, Simon; Le Gonidec, Sophie; Saint Laurent, Céline; Vomscheid, Maëlle; Wanecq, Estelle; Tréguer, Karine; De Rocca Serra-Nédélec, Audrey; Vinel, Claire; Marques, Marie-Adeline; Pozzo, Joffrey; Kunduzova, Oksana; Salles, Jean-Pierre; Tauber, Maithé; Raynal, Patrick; Cavé, Hélène; Edouard, Thomas; Valet, Philippe; Yart, Armelle

    2014-10-21

    LEOPARD syndrome (multiple Lentigines, Electrocardiographic conduction abnormalities, Ocular hypertelorism, Pulmonary stenosis, Abnormal genitalia, Retardation of growth, sensorineural Deafness; LS), also called Noonan syndrome with multiple lentigines (NSML), is a rare autosomal dominant disorder associating various developmental defects, notably cardiopathies, dysmorphism, and short stature. It is mainly caused by mutations of the PTPN11 gene that catalytically inactivate the tyrosine phosphatase SHP2 (Src-homology 2 domain-containing phosphatase 2). Besides its pleiotropic roles during development, SHP2 plays key functions in energetic metabolism regulation. However, the metabolic outcomes of LS mutations have never been examined. Therefore, we performed an extensive metabolic exploration of an original LS mouse model, expressing the T468M mutation of SHP2, frequently borne by LS patients. Our results reveal that, besides expected symptoms, LS animals display a strong reduction of adiposity and resistance to diet-induced obesity, associated with overall better metabolic profile. We provide evidence that LS mutant expression impairs adipogenesis, triggers energy expenditure, and enhances insulin signaling, three features that can contribute to the lean phenotype of LS mice. Interestingly, chronic treatment of LS mice with low doses of MEK inhibitor, but not rapamycin, resulted in weight and adiposity gains. Importantly, preliminary data in a French cohort of LS patients suggests that most of them have lower-than-average body mass index, associated, for tested patients, with reduced adiposity. Altogether, these findings unravel previously unidentified characteristics for LS, which could represent a metabolic benefit for patients, but may also participate to the development or worsening of some traits of the disease. Beyond LS, they also highlight a protective role of SHP2 global LS-mimicking modulation toward the development of obesity and associated disorders.

  17. Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

    International Nuclear Information System (INIS)

    Noda, Saori; Takahashi, Atsushi; Hayashi, Takeru; Tanuma, Sei-ichi; Hatakeyama, Masanori

    2016-01-01

    SHP2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that plays a key role in the proliferation of cells via RAS-ERK activation. SHP2 also promotes Wnt signaling by dephosphorylating parafibromin. Germline missense mutations of PTPN11 are found in more than half of patients with Noonan syndrome (NS) and LEOPARD syndrome (LS), both of which are congenital developmental disorders with multiple common symptoms. However, whereas NS-associated PTPN11 mutations give rise to gain-of-function SHP2 mutants, LS-associated SHP2 mutants are reportedly loss-of-function mutants. To determine the phosphatase activity of LS-associated SHP2 more appropriately, we performed an in vitro phosphatase assay using tyrosine-phosphorylated parafibromin, a biologically relevant substrate of SHP2 and the positive regulator of Wnt signaling that is activated through SHP2-mediated dephosphorylation. We found that LS-associated SHP2 mutants (Y279C, T468M, Q506P, and Q510E) exhibited a substantially reduced phosphatase activity toward parafibromin when compared with wild-type SHP2. Furthermore, each of the LS-associated mutants displayed a differential degree of decrease in phosphatase activity. Deviation of the SHP2 catalytic activity from a certain range, either too strong or too weak, may therefore lead to similar clinical outcomes in NS and LS, possibly through an imbalanced Wnt signal caused by inadequate dephosphorylation of parafibromin. - Highlights: • LS-associated SHP2 mutants dephosphorylate parafibromin on Y290, Y293, and Y315. • LS-associated SHP2 mutants display a reduced tyrosine phosphatase activity. • LS-specific SHP2-Y279C is catalytically less active than LS-specific SHP2-T468M. • NS/LS-associated SHP2-Q506P has both hyper- and hypomorphic enzymatic properties.

  18. Determination of the catalytic activity of LEOPARD syndrome-associated SHP2 mutants toward parafibromin, a bona fide SHP2 substrate involved in Wnt signaling

    Energy Technology Data Exchange (ETDEWEB)

    Noda, Saori [Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo (Japan); Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba (Japan); Takahashi, Atsushi; Hayashi, Takeru [Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo (Japan); Tanuma, Sei-ichi [Department of Biochemistry, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Chiba (Japan); Hatakeyama, Masanori, E-mail: mhata@m.u-tokyo.ac.jp [Division of Microbiology, Graduate School of Medicine, The University of Tokyo, Tokyo (Japan)

    2016-01-22

    SHP2, encoded by the PTPN11 gene, is a protein tyrosine phosphatase that plays a key role in the proliferation of cells via RAS-ERK activation. SHP2 also promotes Wnt signaling by dephosphorylating parafibromin. Germline missense mutations of PTPN11 are found in more than half of patients with Noonan syndrome (NS) and LEOPARD syndrome (LS), both of which are congenital developmental disorders with multiple common symptoms. However, whereas NS-associated PTPN11 mutations give rise to gain-of-function SHP2 mutants, LS-associated SHP2 mutants are reportedly loss-of-function mutants. To determine the phosphatase activity of LS-associated SHP2 more appropriately, we performed an in vitro phosphatase assay using tyrosine-phosphorylated parafibromin, a biologically relevant substrate of SHP2 and the positive regulator of Wnt signaling that is activated through SHP2-mediated dephosphorylation. We found that LS-associated SHP2 mutants (Y279C, T468M, Q506P, and Q510E) exhibited a substantially reduced phosphatase activity toward parafibromin when compared with wild-type SHP2. Furthermore, each of the LS-associated mutants displayed a differential degree of decrease in phosphatase activity. Deviation of the SHP2 catalytic activity from a certain range, either too strong or too weak, may therefore lead to similar clinical outcomes in NS and LS, possibly through an imbalanced Wnt signal caused by inadequate dephosphorylation of parafibromin. - Highlights: • LS-associated SHP2 mutants dephosphorylate parafibromin on Y290, Y293, and Y315. • LS-associated SHP2 mutants display a reduced tyrosine phosphatase activity. • LS-specific SHP2-Y279C is catalytically less active than LS-specific SHP2-T468M. • NS/LS-associated SHP2-Q506P has both hyper- and hypomorphic enzymatic properties.

  19. Hydropower potential of the lower Vistula

    Directory of Open Access Journals (Sweden)

    Michał Szydłowski

    2015-03-01

    Full Text Available This paper presents an estimate analysis of the hydropower potential of the lower Vistula River from Warsaw to Gdańsk Bay. The calculations were made for a hydraulic model of the lower Vistula which takes into account potential development of barrages in a cascade system. Results obtained from the model simulations and from hydrological calculations were used to estimate the power of hydropower plants and the average annual energy output from the entire cascade system. The results of calculations indicate significant energy benefits resulting from the development of a cascade of hydropower plants in the lower Vistula. This study does not discuss the cascade project’s economic viability or other aspects of its development (inland waterways, flood control, etc..

  20. Hydropower Regulatory and Permitting Information Desktop (RAPID) Toolkit

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Aaron L [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-12-19

    Hydropower Regulatory and Permitting Information Desktop (RAPID) Toolkit presentation from the WPTO FY14-FY16 Peer Review. The toolkit is aimed at regulatory agencies, consultants, project developers, the public, and any other party interested in learning more about the hydropower regulatory process.

  1. Modelling the feasibility of retrofitting hydropower to existing South ...

    African Journals Online (AJOL)

    An investigation was carried out with the primary objective of ascertaining whether it is possible to develop a model for determining the feasibility of retrofitting hydropower to existing dams in South Africa. The need for such a model is primarily due to the growing importance of small-scale hydropower projects resulting from ...

  2. 78 FR 58535 - Hydropower Regulatory Efficiency Act of 2013; Supplemental Notice of Workshop

    Science.gov (United States)

    2013-09-24

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD13-9-000] Hydropower... license for hydropower development at non-powered dams and closed-loop pumped storage projects in compliance with section 6 of the Hydropower Regulatory Efficiency Act of 2013. The workshop will be held in...

  3. 78 FR 55251 - Hydropower Regulatory Efficiency Act of 2013; Notice of Workshop

    Science.gov (United States)

    2013-09-10

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD13-9-000] Hydropower... hydropower development at non-powered dams and closed-loop pumped storage projects in compliance with section 6 of the Hydropower Regulatory Efficiency Act of 2013. Participants should be prepared to discuss...

  4. 77 FR 30308 - Proposed Renewal of Information Collection: Alternatives Process in Hydropower Licensing

    Science.gov (United States)

    2012-05-22

    ...: Alternatives Process in Hydropower Licensing AGENCY: Office of the Secretary, Office of Environmental Policy... the Alternatives Process in Hydropower Licensing, OMB Control Number 1094-0001. FOR FURTHER... more of the Departments develop for inclusion in a hydropower license issued by the Federal Energy...

  5. 76 FR 12103 - Erie Boulevard Hydropower, L.P; Notice of Settlement Agreement and Soliciting Comments

    Science.gov (United States)

    2011-03-04

    ... Hydropower, L.P; Notice of Settlement Agreement and Soliciting Comments Take notice that the following... Boulevard Hydropower, L.P. e. Location: The existing multi-development project is located on the Oswegatchie... 791 (a)-825(r) h. Applicant Contact: Daniel Daoust, Erie Boulevard Hydropower, 33 West 1st Street...

  6. Enhancing SHP-1 expression with 5-azacytidine may inhibit STAT3 activation and confer sensitivity in lestaurtinib (CEP-701)-resistant FLT3-ITD positive acute myeloid leukemia

    International Nuclear Information System (INIS)

    Al-Jamal, Hamid Ali Nagi; Mat Jusoh, Siti Asmaa; Hassan, Rosline; Johan, Muhammad Farid

    2015-01-01

    Tumor-suppressor genes are inactivated by methylation in several cancers including acute myeloid leukemia (AML). Src homology-2 (SH2)-containing protein-tyrosine phosphatase 1 (SHP-1) is a negative regulator of the JAK/STAT pathway. Transcriptional silencing of SHP-1 plays a critical role in the development and progression of cancers through STAT3 activation. 5-Azacytidine (5-Aza) is a DNA methyltransferase inhibitor that causes DNA demethylation resulting in re-expression of silenced SHP-1. Lestaurtinib (CEP-701) is a multi-targeted tyrosine kinase inhibitor that potently inhibits FLT3 tyrosine kinase and induces hematological remission in AML patients harboring the internal tandem duplication of the FLT3 gene (FLT3-ITD). However, the majority of patients in clinical trials developed resistance to CEP-701. Therefore, the aim of this study, was to assess the effect of re-expression of SHP-1 on sensitivity to CEP-701 in resistant AML cells. Resistant cells harboring the FLT3-ITD were developed by overexposure of MV4-11 to CEP-701, and the effects of 5-Aza treatment were investigated. Apoptosis and cytotoxicity of CEP-701 were determined using Annexin V and MTS assays, respectively. Gene expression was performed by quantitative real-time PCR. STATs activity was examined by western blotting and the methylation profile of SHP-1 was studied using MS-PCR and pyrosequencing analysis. Repeated-measures ANOVA and Kruskal–Wallis tests were used for statistical analysis. The cytotoxic dose of CEP-701 on resistant cells was significantly higher in comparison with parental and MV4-11R-cep + 5-Aza cells (p = 0.004). The resistant cells showed a significant higher viability and lower apoptosis compared with other cells (p < 0.001). Expression of SHP-1 was 7-fold higher in MV4-11R-cep + 5-Aza cells compared to parental and resistant cells (p = 0.011). STAT3 was activated in resistant cells. Methylation of SHP-1 was significantly decreased in MV4-11R-cep + 5-Aza cells (p = 0

  7. Low-head hydropower impacts on steam dissolved oxygen

    International Nuclear Information System (INIS)

    Thene, J.R.; Stefan, H.G.; Daniil, E.I.

    1989-01-01

    A method to evaluate the effect of hydropower development on downstream dissolved oxygen (DO) is presented for a low head dam. Water, previously aerated during release over spillways and under gates, is diverted through the hydropower facility without further aeration. The oxygen transfer that occurs as a result of air entrainment at the various release points of a dam is measured. Oxygen transfer efficiencies are calculated and incorporated into an oxygen transfer model to predict average release DO concentrations. This model is used to systematically determine the effect of hydropower operation on downstream DO. Operational alternatives are investigated and a simple operational guide is developed to mitigate the effects of hydropower operation. Combinations of reduced generation and optimal releases from the dam allow the hydropower facility to operate within DO standards

  8. The Theun-Hinboun public-private partnership: a critique of the Asian Development Bank's model hydropower venture in Lao PDR

    International Nuclear Information System (INIS)

    Ryder, G.

    1999-10-01

    Financing of the Theun-Hinboun hydroelectric project in Laos, developed by Statkraft, the Norwegian state utility and Vattenfall, its Swedish counterpart, is critiqued. The two utilities put up $ 22 million for Nordic Hydropower's stake in the project and the Norwegian agency for development cooperation provided $ 8 million more for feasibility study, design and environmental mitigation plans. The project was supervised by Nordic Hydropower, a company which also has the contract for operation and management. Electrical and mechanical equipment was supplied by Norwegian and Swedish companies with financing from Nordic export credit agencies and the multilateral Nordic Investment Bank. Proponents of the project consider it as a great success, a 'first' in terms of foreign investment, legal framework, financing, cross-border electricity sale (to Thailand) and logistics. This report suggests that the biggest success of the project's proponents has been their ability to cajole private investors into an otherwise 'unbankable' venture in Laos, which would never have been backed by commercial lenders, who quite apart from country-specific risks, regard hydrodams as high-risk, low return investments, with a reputation for cost overruns and delays due to environmental problems and public opposition, had it not been for the zeal of the Asian Development Bank for public-private partnership. It is charged that as a result of this zeal, willingly assisted by the Nordic export credit agencies, the Government of Laos, and the Electricity Generating Authority of Thailand (EGAT), each for its private reasons, taxpayers responsible for these institutions have been forced to shoulder risks that the private sector prudently refused to take. As part-owners of the project, Lao citizens owe the Asian Development Bank $ 60 million, taxpayers in Nordic countries are responsible for $ 70 million and Thai taxpayers (owners of 20 per cent of the project) will also have to pay irrespective of

  9. Multi-Objective Optimization for Analysis of Changing Trade-Offs in the Nepalese Water-Energy-Food Nexus with Hydropower Development

    DEFF Research Database (Denmark)

    Dhaubanjar, Sanita; Davidsen, Claus; Bauer-Gottwein, Peter

    2017-01-01

    transmission constraints using an optimal power flow approach. Basin inflows, hydropower plant specifications, reservoir characteristics, reservoir rules, irrigation water demand, environmental flow requirements, power demand, and transmission line properties are provided as model inputs. The trade......-established water and power system models to develop a decision support tool combining multiple nexus objectives in a linear objective function. To demonstrate our framework, we compare eight Nepalese power development scenarios based on five nexus objectives: minimization of power deficit, maintenance of water...... availability for irrigation to support food self-sufficiency, reduction in flood risk, maintenance of environmental flows, and maximization of power export. The deterministic multi-objective optimization model is spatially resolved to enable realistic representation of the nexus linkages and accounts for power...

  10. Proven but new. Innovation of hydropower

    Energy Technology Data Exchange (ETDEWEB)

    Harreiter, Herfried [Verbund Hydro Power AG, Vienna (Austria); Godde, Dominik [E.ON Generation GmbH, Hannover (Germany); Zickermann, Richard [ALSTOM (Schweiz) AG, Baden (Switzerland)

    2012-07-01

    Hydropower has been utilised traditionally and its technology is being further developed and advanced. Current developments are addressed by outlining the challenges for operators and manufacturers. The case examples show a wide range of possible innovations. This refers to single components up to novel overall concepts like hybrid plants and compact turbine plants as well as run-of-river power plants. (orig.)

  11. Cell surface expression of channel catfish leukocyte immune-type receptors (IpLITRs) and recruitment of both Src homology 2 domain-containing protein tyrosine phosphatase (SHP)-1 and SHP-2.

    Science.gov (United States)

    Montgomery, Benjamin C S; Mewes, Jacqueline; Davidson, Chelsea; Burshtyn, Deborah N; Stafford, James L

    2009-04-01

    Channel catfish leukocyte immune-type receptors (IpLITRs) are immunoglobulin superfamily (IgSF) members believed to play a role in the control and coordination of cellular immune responses in teleost. Putative stimulatory and inhibitory IpLITRs are co-expressed by different types of catfish immune cells (e.g. NK cells, T cells, B cells, and macrophages) but their signaling potential has not been determined. Following cationic polymer-mediated transfections into human cell lines we examined the surface expression, tyrosine phosphorylation, and phosphatase recruitment potential of two types of putative inhibitory IpLITRs using 'chimeric' expression constructs and an epitope-tagged 'native' IpLITR. We also cloned and expressed the teleost Src homology 2 domain-containing protein tyrosine phosphatases (SHP)-1 and SHP-2 and examined their expression in adult tissues and developing zebrafish embryos. Co-immunoprecipitation experiments support the inhibitory signaling potential of distinct IpLITR-types that bound both SHP-1 and SHP-2 following the phosphorylation of tyrosine residues within their cytoplasmic tail (CYT) regions. Phosphatase recruitment by IpLITRs represents an important first step in understanding their influence on immune cell effector functions and suggests that certain inhibitory signaling pathways are conserved among vertebrates.

  12. Shp2 Associates with and Enhances Nephrin Tyrosine Phosphorylation and Is Necessary for Foot Process Spreading in Mouse Models of Podocyte Injury

    Science.gov (United States)

    Verma, Rakesh; Venkatareddy, Madhusudan; Kalinowski, Anne; Patel, Sanjeevkumar R.; Salant, David J.

    2015-01-01

    In most forms of glomerular diseases, loss of size selectivity by the kidney filtration barrier is associated with changes in the morphology of podocytes. The kidney filtration barrier is comprised of the endothelial lining, the glomerular basement membrane, and the podocyte intercellular junction, or slit diaphragm. The cell adhesion proteins nephrin and neph1 localize to the slit diaphragm and transduce signals in a Src family kinase Fyn-mediated tyrosine phosphorylation-dependent manner. Studies in cell culture suggest nephrin phosphorylation-dependent signaling events are primarily involved in regulation of actin dynamics and lamellipodium formation. Nephrin phosphorylation is a proximal event that occurs both during development and following podocyte injury. We hypothesized that abrogation of nephrin phosphorylation following injury would prevent nephrin-dependent actin remodeling and foot process morphological changes. Utilizing a biased screening approach, we found nonreceptor Src homology 2 (sh2) domain-containing phosphatase Shp2 to be associated with phosphorylated nephrin. We observed an increase in nephrin tyrosine phosphorylation in the presence of Shp2 in cell culture studies. In the human glomerulopathies minimal-change nephrosis and membranous nephropathy, there is an increase in Shp2 phosphorylation, a marker of increased Shp2 activity. Mouse podocytes lacking Shp2 do not develop foot process spreading when subjected to podocyte injury in vivo using protamine sulfate or nephrotoxic serum (NTS). In the NTS model, we observed a lack of foot process spreading in mouse podocytes with Shp2 deleted and smaller amounts of proteinuria. Taken together, these results suggest that Shp2-dependent signaling events are necessary for changes in foot process structure and function following injury. PMID:26644409

  13. System dynamics in hydropower plants

    Energy Technology Data Exchange (ETDEWEB)

    Stuksrud, Dag Birger

    1998-12-31

    The main purpose of this thesis on system dynamics in hydropower plants was to establish new models of a hydropower system where the turbine/conduits and the electricity supply and generation are connected together as one unit such that possible interactions between the two power regimes can be studied. In order to describe the system dynamics as well as possible, a previously developed analytic model of high-head Francis turbines is improved. The model includes the acceleration resistance in the turbine runner and the draft tube. Expressions for the loss coefficients in the model are derived in order to obtain a purely analytic model. The necessity of taking the hydraulic inertia into account is shown by means of simulations. Unstable behaviour and a higher transient turbine speed than expected may occur for turbines with steep characteristics or large draft tubes. The turbine model was verified previously with respect to a high-head Francis turbine; the thesis performs an experimental verification on a low-head Francis turbine and compares the measurements with simulations from the improved turbine model. It is found that the dynamic turbine model is, after adjustment, capable of describing low-head machines as well with satisfying results. The thesis applies a method called the ``Limited zero-pole method`` to obtain new rational approximations of the elastic behaviour in the conduits with frictional damping included. These approximations are used to provide an accurate state space formulation of a hydropower plant. Simulations performed with the new computer programs show that hydraulic transients such as water-hammer and mass oscillations are reflected in the electric grid. Unstable governing performance in the electric and hydraulic parts also interact. This emphasizes the need for analysing the whole power system as a unit. 63 refs., 149 figs., 4 tabs.

  14. Lipoic Acid Decreases the Viability of Breast Cancer Cells and Activity of PTP1B and SHP2.

    Science.gov (United States)

    Kuban-Jankowska, Alicja; Gorska-Ponikowska, Magdalena; Wozniak, Michal

    2017-06-01

    Protein tyrosine phosphatases PTP1B and SHP2 are potential targets for anticancer therapy, because of the essential role they play in the development of tumors. PTP1B and SHP2 are overexpressed in breast cancer cells, thus inhibition of their activity can be potentially effective in breast cancer therapy. Lipoic acid has been previously reported to inhibit the proliferation of colon, breast and thyroid cancer cells. We investigated the effect of alpha-lipoic acid (ALA) and its reduced form of dihydrolipoic acid (DHLA) on the viability of MCF-7 cancer cells and on the enzymatic activity of PTP1B and SHP2 phosphatases. ALA and DHLA decrease the activity of PTP1B and SHP2, and have inhibitory effects on the viability and proliferation of breast cancer cells. ALA and DHLA can be considered as potential agents for the adjunctive treatment of breast cancer. Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

  15. Minimizing water consumption when producing hydropower

    Science.gov (United States)

    Leon, A. S.

    2015-12-01

    In 2007, hydropower accounted for only 16% of the world electricity production, with other renewable sources totaling 3%. Thus, it is not surprising that when alternatives are evaluated for new energy developments, there is strong impulse for fossil fuel or nuclear energy as opposed to renewable sources. However, as hydropower schemes are often part of a multipurpose water resources development project, they can often help to finance other components of the project. In addition, hydropower systems and their associated dams and reservoirs provide human well-being benefits, such as flood control and irrigation, and societal benefits such as increased recreational activities and improved navigation. Furthermore, hydropower due to its associated reservoir storage, can provide flexibility and reliability for energy production in integrated energy systems. The storage capability of hydropower systems act as a regulating mechanism by which other intermittent and variable renewable energy sources (wind, wave, solar) can play a larger role in providing electricity of commercial quality. Minimizing water consumption for producing hydropower is critical given that overuse of water for energy production may result in a shortage of water for other purposes such as irrigation, navigation or fish passage. This paper presents a dimensional analysis for finding optimal flow discharge and optimal penstock diameter when designing impulse and reaction water turbines for hydropower systems. The objective of this analysis is to provide general insights for minimizing water consumption when producing hydropower. This analysis is based on the geometric and hydraulic characteristics of the penstock, the total hydraulic head and the desired power production. As part of this analysis, various dimensionless relationships between power production, flow discharge and head losses were derived. These relationships were used to withdraw general insights on determining optimal flow discharge and

  16. Future changes in Yuan River ecohydrology: Individual and cumulative impacts of climates change and cascade hydropower development on runoff and aquatic habitat quality.

    Science.gov (United States)

    Wen, Xin; Liu, Zhehua; Lei, Xiaohui; Lin, Rongjie; Fang, Guohua; Tan, Qiaofeng; Wang, Chao; Tian, Yu; Quan, Jin

    2018-08-15

    The eco-hydrological system in southwestern China is undergoing great changes in recent decades owing to climate change and extensive cascading hydropower exploitation. With a growing recognition that multiple drivers often interact in complex and nonadditive ways, the purpose of this study is to predict the potential future changes in streamflow and fish habitat quality in the Yuan River and quantify the individual and cumulative effect of cascade damming and climate change. The bias corrected and spatial downscaled Coupled Model Intercomparison Project Phase 5 (CMIP5) General Circulation Model (GCM) projections are employed to drive the Soil and Water Assessment Tool (SWAT) hydrological model and to simulate and predict runoff responses under diverse scenarios. Physical habitat simulation model is established to quantify the relationship between river hydrology and fish habitat, and the relative change rate is used to assess the individual and combined effects of cascade damming and climate change. Mean annual temperature, precipitation and runoff in 2015-2100 show an increasing trend compared with that in 1951-2010, with a particularly pronounced difference between dry and wet years. The ecological habitat quality is improved under cascade hydropower development since that ecological requirement has been incorporated in the reservoir operation policy. As for middle reach, the runoff change from January to August is determined mainly by damming, and climate change influence becomes more pronounced in dry seasons from September to December. Cascade development has an effect on runoff of lower reach only in dry seasons due to the limited regulation capacity of reservoirs, and climate changes have an effect on runoff in wet seasons. Climate changes have a less significant effect on fish habitat quality in middle reach than damming, but a more significant effect in lower reach. In addition, the effect of climate changes on fish habitat quality in lower reach is high

  17. ESTIMATING HYDROPOWER POTENTIAL OF SMALL RIVERS OF REPUBLIC OF MOLDOVA USING GIS

    Directory of Open Access Journals (Sweden)

    T. CASTRAVEŢ

    2018-06-01

    Full Text Available Estimating hydropower potential of small rivers of Republic of Moldova using GIS, The increasing demand for energy, especially from renewable and sustainable sources, spurs the development of small hydropower plants and encourages investment in new survey studies (Larentis et al., 2010. Preliminary hydropower survey studies usually carry huge uncertainties about the technical, economic and environmental feasibility of the undeveloped potential. This paper presents a methodology for hydropower potential sites assessment. The sequence of procedures to identify hydropower sites is based on remote sensing data and streamflow and rainfall data and was automated within GIS environment.

  18. Hydropower and the world's energy future

    International Nuclear Information System (INIS)

    2000-11-01

    The potential role of hydropower in the context of world-wide demographic growth and increasing demand for energy, and the benefits inherent in hydroelectric power in comparison with other energy options are discussed. Environmental and social impacts, and examples of mitigation measures are reviewed. Recommendations regarding best practices in the future development of hydroelectric power projects proposed

  19. Improving the ecohydrological and economic efficiency of Small Hydropower Plants with water diversion

    Science.gov (United States)

    Razurel, Pierre; Gorla, Lorenzo; Tron, Stefania; Niayifar, Amin; Crouzy, Benoît; Perona, Paolo

    2018-03-01

    Water exploitation for energy production from Small Hydropower Plant (SHP) is increasing despite human pressure on freshwater already being very intense in several countries. Preserving natural rivers thus requires deeper understanding of the global (i.e., ecological and economic) efficiency of flow-diversion practice. In this work, we show that the global efficiency of SHP river intakes can be improved by non-proportional flow-redistribution policies. This innovative dynamic water allocation defines the fraction of water released to the river as a nonlinear function of river runoff. Three swiss SHP case studies are considered to systematically test the global performance of such policies, under both present and future hydroclimatic regimes. The environmental efficiency is plotted versus the economic efficiency showing that efficient solutions align along a (Pareto) frontier, which is entirely formed by non-proportional policies. On the contrary, other commonly used distribution policies generally lie below the Pareto frontier. This confirms the existence of better policies based on non-proportional redistribution, which should be considered in relation to implementation and operational costs. Our results recommend abandoning static (e.g., constant-minimal-flow) policies in favour of non-proportional dynamic ones towards a more sustainable use of the water resource, also considering changing hydroclimatic scenarios.

  20. Environmental impact of hydropower systems

    International Nuclear Information System (INIS)

    Malai, Marius

    1996-01-01

    The installed hydropower potential of Romania is evaluated to 15,700 MW and 42 billion MWh/year power generation. Only 39% of this potential are currently being utilized. In this note, the impact of Somes-Tarnita and Mariselu-Cluj hydropower systems on the environment is presented. Also, the socio-economic effects on the local communities are considered. These two hydropower systems supply a total electric power of 470 GWh/year

  1. Hydropower's Biogenic Carbon Footprint.

    Science.gov (United States)

    Scherer, Laura; Pfister, Stephan

    2016-01-01

    Global warming is accelerating and the world urgently needs a shift to clean and renewable energy. Hydropower is currently the largest renewable source of electricity, but its contribution to climate change mitigation is not yet fully understood. Hydroelectric reservoirs are a source of biogenic greenhouse gases and in individual cases can reach the same emission rates as thermal power plants. Little is known about the severity of their emissions at the global scale. Here we show that the carbon footprint of hydropower is far higher than previously assumed, with a global average of 173 kg CO2 and 2.95 kg CH4 emitted per MWh of electricity produced. This results in a combined average carbon footprint of 273 kg CO2e/MWh when using the global warming potential over a time horizon of 100 years (GWP100). Nonetheless, this is still below that of fossil energy sources without the use of carbon capture and sequestration technologies. We identified the dams most promising for capturing methane for use as alternative energy source. The spread among the ~1500 hydropower plants analysed in this study is large and highlights the importance of case-by-case examinations.

  2. Hydropower's Biogenic Carbon Footprint

    Science.gov (United States)

    Pfister, Stephan

    2016-01-01

    Global warming is accelerating and the world urgently needs a shift to clean and renewable energy. Hydropower is currently the largest renewable source of electricity, but its contribution to climate change mitigation is not yet fully understood. Hydroelectric reservoirs are a source of biogenic greenhouse gases and in individual cases can reach the same emission rates as thermal power plants. Little is known about the severity of their emissions at the global scale. Here we show that the carbon footprint of hydropower is far higher than previously assumed, with a global average of 173 kg CO2 and 2.95 kg CH4 emitted per MWh of electricity produced. This results in a combined average carbon footprint of 273 kg CO2e/MWh when using the global warming potential over a time horizon of 100 years (GWP100). Nonetheless, this is still below that of fossil energy sources without the use of carbon capture and sequestration technologies. We identified the dams most promising for capturing methane for use as alternative energy source. The spread among the ~1500 hydropower plants analysed in this study is large and highlights the importance of case-by-case examinations. PMID:27626943

  3. Hydro-power

    International Nuclear Information System (INIS)

    Piro, P.

    2010-01-01

    On average the hydro-power sector produces 12% of the electrical power in France. A quarter of this production might pass to another operator than EDF because the end of some grants is nearing (2012 for 12 installations). In France the power of rivers belongs to the state that gives operators grants to harness it. The allowance lasts 75 years usually but for installations below 4.5 MW a permanent and definitive grant is allowed. Most installations are ancient and their investment have been paid off since a long, so hydro-power is the most profitable renewable energy in France. A lot of bidders are expected. Each bid will be assessed on 3 criteria: -) the global energy efficiency of the waterfall, -) a balanced management of the water resource, and -) an economic and financial offer to the state. The balance between the different uses of water is getting more delicate to reach and this renewal of grants will be an opportunity for the state to impose a better preservation of the environment. In July 2008, the French government announced a program for the re launching of the hydro-power, this program has been reduced and now only 3000 GWh supplementary are expected by 2020. (A.C.)

  4. DOE Hydropower Program Annual Report for FY 2002

    Energy Technology Data Exchange (ETDEWEB)

    Garold L. Sommers; R. T. Hunt

    2003-07-01

    The U.S. Department of Energy (DOE) conducts research on advanced hydropower technology through its hydropower program, which is organized under the Office of Wind and Hydropower Technologies within the Office of Energy Efficiency and Renewable Energy. This annual report describes the various projects supported by the hydropower program in FY 2002. The program=s current focus is on improving the environmental performance of hydropower projects by addressing problems such as fish mortality during passage through turbines, alteration of instream habitat, and water quality in tailwaters. A primary goal of this research is to develop new, environmentally friendly technology. DOE-funded projects have produced new conceptual designs for turbine systems, and these are now being tested in pilot-scale laboratory tests and in the field. New design approaches range from totally new turbine runners to modifications of existing designs. Biological design criteria for these new turbines have also been developed in controlled laboratory tests of fish response to physical stresses, such as hydraulic shear and pressure changes. These biocriteria are being combined with computational tools to locate and eliminate areas inside turbine systems that are damaging to fish. Through the combination of laboratory, field, and computational studies, new solutions are being found to environmental problems at hydropower projects. The diverse program activities continue to make unique contributions to clean energy production in the U.S. By working toward technology improvements that can reduce environmental problems, the program is helping to reposition hydropower as an acceptable, renewable, domestic energy choice.

  5. China’s rising hydropower demand challenges water sector

    Science.gov (United States)

    Liu, Junguo; Zhao, Dandan; Gerbens-Leenes, P. W.; Guan, Dabo

    2015-01-01

    Demand for hydropower is increasing, yet the water footprints (WFs) of reservoirs and hydropower, and their contributions to water scarcity, are poorly understood. Here, we calculate reservoir WFs (freshwater that evaporates from reservoirs) and hydropower WFs (the WF of hydroelectricity) in China based on data from 875 representative reservoirs (209 with power plants). In 2010, the reservoir WF totaled 27.9 × 109 m3 (Gm3), or 22% of China’s total water consumption. Ignoring the reservoir WF seriously underestimates human water appropriation. The reservoir WF associated with industrial, domestic and agricultural WFs caused water scarcity in 6 of the 10 major Chinese river basins from 2 to 12 months annually. The hydropower WF was 6.6 Gm3 yr−1 or 3.6 m3 of water to produce a GJ (109 J) of electricity. Hydropower is a water intensive energy carrier. As a response to global climate change, the Chinese government has promoted a further increase in hydropower energy by 70% by 2020 compared to 2012. This energy policy imposes pressure on available freshwater resources and increases water scarcity. The water-energy nexus requires strategic and coordinated implementations of hydropower development among geographical regions, as well as trade-off analysis between rising energy demand and water use sustainability. PMID:26158871

  6. Greaseless Bushings for Hydropower Applications: Program, Testing, and Results

    National Research Council Canada - National Science Library

    Jones, John

    1999-01-01

    ...) bushings at its hydropower and navigation facilities. Products of this type currently on the market, however, were not specifically developed for the high-load, low-speed oscillating operating conditions typical for power-generation machinery...

  7. Detection of Intracellular Reduced (Catalytically Active) SHP-1 and Analyses of Catalytically Inactive SHP-1 after Oxidation by Pervanadate or H2O2.

    Science.gov (United States)

    Choi, Seeyoung; Love, Paul E

    2018-01-05

    Oxidative inactivation of cysteine-dependent Protein Tyrosine Phosphatases (PTPs) by cellular reactive oxygen species (ROS) plays a critical role in regulating signal transduction in multiple cell types. The phosphatase activity of most PTPs depends upon a 'signature' cysteine residue within the catalytic domain that is maintained in the de-protonated state at physiological pH rendering it susceptible to ROS-mediated oxidation. Direct and indirect techniques for detection of PTP oxidation have been developed (Karisch and Neel, 2013). To detect catalytically active PTPs, cell lysates are treated with iodoacetyl-polyethylene glycol-biotin (IAP-biotin), which irreversibly binds to reduced (S - ) cysteine thiols. Irreversible oxidation of SHP-1 after treatment of cells with pervanadate or H 2 O 2 is detected with antibodies specific for the sulfonic acid (SO 3 H) form of the conserved active site cysteine of PTPs. In this protocol, we describe a method for the detection of the reduced (S - ; active) or irreversibly oxidized (SO 3 H; inactive) form of the hematopoietic PTP SHP-1 in thymocytes, although this method is applicable to any cysteine-dependent PTP in any cell type.

  8. Hydropower externalities: a meta analysis

    NARCIS (Netherlands)

    Mattmann, M.; Logar, I.; Brouwer, R.

    2016-01-01

    This paper presents a meta-analysis of existing research related to the economic valuation of the external effects of hydropower. A database consisting of 81 observations derived from 29 studies valuing the non-market impacts of hydropower electricity generation is constructed with the main aim to

  9. Multi-Objective Optimization for Analysis of Changing Trade-Offs in the Nepalese Water–Energy–Food Nexus with Hydropower Development

    Directory of Open Access Journals (Sweden)

    Sanita Dhaubanjar

    2017-02-01

    Full Text Available While the water–energy–food nexus approach is becoming increasingly important for more efficient resource utilization and economic development, limited quantitative tools are available to incorporate the approach in decision-making. We propose a spatially explicit framework that couples two well-established water and power system models to develop a decision support tool combining multiple nexus objectives in a linear objective function. To demonstrate our framework, we compare eight Nepalese power development scenarios based on five nexus objectives: minimization of power deficit, maintenance of water availability for irrigation to support food self-sufficiency, reduction in flood risk, maintenance of environmental flows, and maximization of power export. The deterministic multi-objective optimization model is spatially resolved to enable realistic representation of the nexus linkages and accounts for power transmission constraints using an optimal power flow approach. Basin inflows, hydropower plant specifications, reservoir characteristics, reservoir rules, irrigation water demand, environmental flow requirements, power demand, and transmission line properties are provided as model inputs. The trade-offs and synergies among these objectives were visualized for each scenario under multiple environmental flow and power demand requirements. Spatially disaggregated model outputs allowed for the comparison of scenarios not only based on fulfillment of nexus objectives but also scenario compatibility with existing infrastructure, supporting the identification of projects that enhance overall system efficiency. Though the model is applied to the Nepalese nexus from a power development perspective here, it can be extended and adapted for other problems.

  10. 78 FR 62322 - Hydropower Regulatory Efficiency Act of 2013; Notice of Rescheduled Two-Year Licensing Process...

    Science.gov (United States)

    2013-10-16

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. AD13-9-000] Hydropower... recommendations on the feasibility of a two-year process for the issuance of a license for hydropower development... Hydropower Regulatory Efficiency Act of 2013. The workshop will be held in the Commission Meeting Room at 888...

  11. Fishy Business: Response of Stream Fish Assemblages to Small Hydro-power Plant Induced Flow Alteration in the Western Ghats, Karnataka

    Science.gov (United States)

    Rao, S. T.; Krishnaswamy, J.; Bhalla, R. S.

    2017-12-01

    Alteration of natural flow regimes is considered as a major threat to freshwater fish assemblages as it disturbs the water quality and micro-habitat features of rivers. Small hydro-power (SHP), which is being promoted as a clean and green substitute for large hydro-power generation, alters the natural flow regime of head-water streams by flow diversion and regulation. The effects of altered flow regime on tropical stream fish assemblages, driven by seasonality induced perturbations to water quality and microhabitat parameters are largely understudied. My study examined the potential consequences of flow alteration by SHPs on fish assemblages in two tributaries of the west-flowing Yettinahole River which flows through the reserved forests of Sakleshpur in the Western Ghats of Karnataka. The flow in one of the tributaries followed natural flow regime while the other comprised three regimes: a near-natural flow regime above the dam, rapidly varying discharge below the dam and a dewatered regime caused by flow diversion. The study found that the altered flow regime differed from natural flow regime in terms of water quality, microhabitat heterogeneity and fish assemblage response, each indicative of the type of flow alteration. Fish assemblage in the natural flow regime was characterized by a higher catch per site, a strong association of endemic and trophic specialist species. The flow regime above the dam was found to mimic some components of the natural flow regime, both ecological and environmental. Non endemic, generalist and pool tolerant species were associated with the dewatered regime. There was a lack of strong species-regime association and an overall low catch per site for the flow regulated regime below the dam. This study highlights the consequences of altered flows on the composition of freshwater fish assemblages and portrays the potential of freshwater fish as indicators of the degree and extent of flow alteration. The study recommends the need for

  12. Standard Modular Hydropower Technology Acceleration Workshop: Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mobley, Miles H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Fernandez, Alisha R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-08-01

    In support of the Department of Energy (DOE) funded Standard Modular Hydropower (SMH) Technology Acceleration project, Oak Ridge National Laboratory (ORNL) staff convened with five small hydropower technology entrepreneurs on June 14 and 15, 2017 to discuss gaps, challenges, and opportunities for small modular hydropower development. The workshop was designed to walk through SMH concepts, discuss the SMH research vision, assess how each participant’s technology aligns with SMH concepts and research, and identify future pathways for mutually beneficial collaboration that leverages ORNL expertise and entrepreneurial industry experience. The goal coming out of the workshop is to advance standardized, scalable, modular hydropower technologies and development approaches with sustained and open dialogue among diverse stakeholder groups.

  13. Hydropower engineering. Paper no. IGEC-1-005

    International Nuclear Information System (INIS)

    Cervantes, M.

    2005-01-01

    Hydropower, one of the corner stones of sustainable energy development, is the largest renewable source of energy. There is a large demand worldwide for people trained to design, operate, maintain and optimise hydropower systems. Hydro Power University, a name which encompasses both education, research and development within hydropower in Sweden, offers a unique and broad international masters programme within hydropower engineering including civil, mechanical and electrical engineering. The programme is the result of a close collaboration between Lulea University of Technology and Uppsala University, at the research and education level. This master programme, Hydropower Engineering, is open to both Swedish and foreign students free of charge. It aims to provide students with state of the art knowledge and experience on parts of the hydropower system such as turbine technology, generator design, rotor dynamics, tribology, dams/dam safety, maintenance and operation and environmental aspects. World unique laboratory experiments are offered to the students at Porjus and Alvkarleby, Sweden. The Porjus Hydropower Centre offers world unique facilities: two full scale turbines of 10 MW each, one with the latest generator technology - Powerformer. The turbines are exclusively dedicated for use in education, research and development. State of the art in measurement technology is available. Both units are at the centre of each education programme offered by the Hydro Power University. In Alvkarleby, spillways, discharge capacity and turbines model testing can be undertaken at the Vattenfall laboratory also with state of the art experimental material and highly qualified staff. The large number of applications from developing countries indicates a need of scholarships, which needs to be resolved for the development of hydropower. (author)

  14. Modeling and dynamic behaviour of hydropower plants

    CERN Document Server

    Kishor, Nand

    2017-01-01

    This book presents a systematic approach to mathematical modeling of different configurations of hydropower plants over four sections - modeling and simulation approaches; control of hydropower plants; operation and scheduling of hydropower plants, including pumped storage; and special features of small hydropower plants.

  15. Hydropower's Contribution to Energy Security

    Energy Technology Data Exchange (ETDEWEB)

    Altinbilek, D.; Abdel-Malek, R.; Devernay, J.M.; Gill, R.; Leney, S.; Moss, Terry; Schiffer, H.P.; Taylor, R.M.

    2007-07-01

    The role of hydropower within mixed power systems is analysed from the point of view of both quantitative and qualitative performance. Interrelationships with all other generation technologies are discussed and synergies identified. Resources, sustainability criteria and investment challenges are reviewed in the context of development. The objective of the paper is to define hydropower's contribution within the clean, clever and competitive markets of the future.

  16. Hydropower is not plain sailing all the way

    International Nuclear Information System (INIS)

    De Vries, E.

    1991-01-01

    A report is given of the conference Hidroenergia 1991, which was held in Nice, France, from 12 to 15 June. The author highlights the subjects on the problems of implementing hydro-power, and the environmental effects of the use of hydro-power. Special attention is paid to the activities of the European Community to limit the constraints, which form hindrances to the development of hydroelectric power. 2 ills., 3 refs

  17. Energy Recovery Hydropower: Prospects for Off-Setting Electricity Costs for Agricultural, Municipal, and Industrial Water Providers and Users; July 2017 - September 2017

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Aaron L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Curtis, Taylor L. [National Renewable Energy Lab. (NREL), Golden, CO (United States); Johnson, Kurt [Telluride Energy; Telluride, CO (United States)

    2018-01-11

    Energy recovery hydropower is one of the most cost-effective types of new hydropower development because it is constructed utilizing existing infrastructure, and it is typically able to complete Federal Energy Regulatory Commission (FERC) review in 60 days. Recent changes in federal and state policy have supported energy recovery hydropower. In addition, some states have developed programs and policies to support energy recovery hydropower, including resource assessments, regulatory streamlining initiatives, and grant and loan programs to reduce project development costs. This report examines current federal and state policy drivers for energy recovery hydropower, reviews market trends, and looks ahead at future federal resource assessments and hydropower reform legislation.

  18. Hydropower systems planning in distribution networks based on GIS

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez-Rosado, I.J.; Zorzano-Santamaria, P.; Fernandez-Jiminez, L.A.; Garcia-Garrido, E.; Zorzano-Alba, E.; Lara-Santillan, P.M.; Mendoza-Villena, M. [La Rioja Univ., La Rioja (Spain). Dept. of Electrical Engineering

    2005-07-01

    Planning models for hydraulic energy systems developed with a new computational geographic information system (GIS) tool were presented. The GIS tool was used to identify sections of rivers that are suitable for small-scale run-of-river hydropower generation in the La Rioja region of Spain. The tool was also used to evaluate economic data related to financing grants, technological costs, installation costs, and forecast demands for various consumption scenarios. Case studies of 2 hydropower systems were used to test the tool. The planning models were based on levelized electric costs (LEC) of run-of-river hydropower systems, and enabled the systems to be analyzed in isolation as well as when connected to an existing electricity network. Results of the modelling studies showed that the tool is capable of analyzing the LEC of potential hydropower systems in a range of different scenarios while maintaining the geographic characteristics and requirements of individual regions. 7 refs., 4 figs.

  19. Phosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndrome.

    Directory of Open Access Journals (Sweden)

    Jeroen Paardekooper Overman

    Full Text Available Noonan syndrome (NS and LEOPARD syndrome (LS cause congenital afflictions such as short stature, hypertelorism and heart defects. More than 50% of NS and almost all of LS cases are caused by activating and inactivating mutations of the phosphatase Shp2, respectively. How these biochemically opposing mutations lead to similar clinical outcomes is not clear. Using zebrafish models of NS and LS and mass spectrometry-based phosphotyrosine proteomics, we identified a down-regulated peptide of Fer kinase in both NS and LS. Further investigation showed a role for Fer during development, where morpholino-based knockdown caused craniofacial defects, heart edema and short stature. During gastrulation, loss of Fer caused convergence and extension defects without affecting cell fate. Moreover, Fer knockdown cooperated with NS and LS, but not wild type Shp2 to induce developmental defects, suggesting a role for Fer in the pathogenesis of both NS and LS.

  20. The tyrosine phosphatase Shp2 interacts with NPM-ALK and regulates anaplastic lymphoma cell growth and migration

    DEFF Research Database (Denmark)

    Voena, Claudia; Conte, Chiara; Ambrogio, Chiara

    2007-01-01

    Anaplastic large cell lymphomas (ALCL) are mainly characterized by the reciprocal translocation t(2;5)(p23;q35) that involves the anaplastic lymphoma kinase (ALK) gene and generates the fusion protein NPM-ALK with intrinsic tyrosine kinase activity. NPM-ALK triggers several signaling cascades......, leading to increased cell growth, resistance to apoptosis, and changes in morphology and migration of transformed cells. To search for new NPM-ALK interacting molecules, we developed a mass spectrometry-based proteomic approach in HEK293 cells expressing an inducible NPM-ALK and identified the tyrosine...... phosphatase Shp2 as a candidate substrate. We found that NPM-ALK was able to bind Shp2 in coprecipitation experiments and to induce its phosphorylation in the tyrosine residues Y542 and Y580 both in HEK293 cells and ALCL cell lines. In primary lymphomas, antibodies against the phosphorylated tyrosine Y542...

  1. Many and small or large and few? A comparison of the environmental effects of different strategies for the development of hydropower plants.; Mange og smaa eller store og faa? En sammenligning av miljoevirkningene ved ulike strategier for utvikling av vannkraft.

    Energy Technology Data Exchange (ETDEWEB)

    Bakken, Tor Haakon; Sundt, Haakon; Ruud, Audun

    2012-11-01

    This study compared the cumulative environmental impact of 27 small hydro power plants to the environmental impact of an average of three large hydropower plants, which range from the small farms and the average of the major producing about as much energy. Based on the empirical basis used in this study are the environmental impacts of large hydropower fewer and less severe than the cumulative environmental impacts from the 27 small plants. The results are, however marginal in favor of big hydro power plants and suffers from uncertainties due to lack of precision in the raw data, limitations of the methodic of accumulating environmental effects of many small facilities and extensive use of discretion in the transition between the scientific description of the environmental impacts and impact classes (Statens Vegvesen, 2006). The input data in the study has primarily been published available environmental impact assessment (KU). The results must therefore be said to have limited power statement in order to draw general conclusions. The identified environmental effects are to some extent, different from the type and size, so that an individual valuation and political or administrative priorities will to a large extent determine the preferred strategy for the development of hydropower. From 2012 promoted the production stimulating action as a result of common certificate market with Sweden. Small hydro power plants has so far been a priority in Norway, but when Norway implements EU Water Framework Directive in all areas of precipitation, one should be aware of our findings, especially regarding the potential in expanding of existing hydropower plants. (auth)

  2. Hydropower: Partnership with the Environment

    Energy Technology Data Exchange (ETDEWEB)

    None

    2001-06-01

    This brochure provides useful information on types of hydroelectric facilities as well as general information on capacity, generation, environmental issues, and advanced conventional hydropower technology within the United States.

  3. Socio-environmental integration of hydropower facilities

    International Nuclear Information System (INIS)

    Harby, Atle; Forseth, Torbjoern; Ruud, Audun; Bakken, Tor Haakon

    2017-01-01

    Centre for Environmental Design of Renewable Energy (CEDREN) is a research centre focusing on hydropower production and environmental impacts of hydropower. The main objective of CEDREN is to develop and communicate design solutions for renewable energy production that address environmental and societal challenges at local, regional, national and global levels. Environmental design means that planning, building and operation have to include technical, economic, environmental and socio-political aspects throughout the whole life-span of the project. Methods and tools to ensure environmental design are developed in CEDREN and applied to case studies in Norway and internationally. These methods and tools focus on finding physical and biological bottlenecks for affected species and ecosystems by mapping, modelling and analysis of both physical conditions and ecological status. CEDREN proposes different measures, tools and methods to improve the environmental conditions as well as how to maintain or increase the power production. In addition, a strong focus must be made on political governance to ensure more representative participation of relevant stakeholders in the process of finding the best technical, economic and political solutions for power production, the environment and the society. Key research findings used to develop relationships between physical factors like flow, flow fluctuations, water temperature, water velocity, water depth and water-covered area and biological response will be shown. Examples of improved methods for better planning procedures with stakeholder engagement will be proposed. Examples of methods and tools for environmental design of hydropower will be given for several regulated rivers in Norway and abroad. (authors)

  4. Expression, prognostic significance and mutational analysis of protein tyrosine phosphatase SHP-1 in chronic myeloid leukemia.

    Science.gov (United States)

    Papadopoulou, Vasiliki; Kontandreopoulou, Elina; Panayiotidis, Panayiotis; Roumelioti, Maria; Angelopoulou, Maria; Kyriazopoulou, Lydia; Diamantopoulos, Panagiotis T; Vaiopoulos, George; Variami, Eleni; Kotsianidis, Ioannis; Athina Viniou, Nora

    2016-05-01

    The protein tyrosine phosphatase SHP-1 dephosphorylates BCR-ABL1, thereby serving as a potential control mechanism of BCR-ABL1 kinase activity. Pathways regulating SHP-1 expression, which could be exploited in the therapeutics of TKI-resistant chronic myeloid leukemia (CML), remain unknown. Moreover, the questions of whether there is any kind of SHP-1 deregulation in CML, contributing to disease initiation or evolution, as well as the question of prognostic significance of SHP-1, have not been definitively answered. This study shows moderately lower SHP-1 mRNA expression in chronic phase CML patients in comparison to healthy individuals and no change in SHP-1 mRNA levels after successful TKI treatment. Mutational analysis of the aminoterminal and phosphatase domains of SHP-1 in patients did not reveal genetic lesions. This study also found no correlation of SHP-1 expression at diagnosis with response to treatment, although a trend for lower SHP-1 expression was noted in the very small non-responders' group of the 3-month therapeutic milestone.

  5. Shp2-Dependent ERK Signaling Is Essential for Induction of Bergmann Glia and Foliation of the Cerebellum

    Science.gov (United States)

    Li, Kairong; Leung, Alan W.; Guo, Qiuxia; Yang, Wentian

    2014-01-01

    Folding of the cortex and the persistence of radial glia (RG)-like cells called Bergmann glia (BG) are hallmarks of the mammalian cerebellum. Similar to basal RG in the embryonic neocortex, BG maintain only basal processes and continuously express neural stem cell markers. Past studies had focused on the function of BG in granule cell migration and how granule cell progenitors (GCP) regulate cerebellar foliation. The molecular control of BG generation and its role in cerebellar foliation are less understood. Here, we have analyzed the function of the protein tyrosine phosphatase Shp2 in mice by deleting its gene Ptpn11 in the entire cerebellum or selectively in the GCP lineage. Deleting Ptpn11 in the entire cerebellum by En1-cre blocks transformation of RG into BG but preserves other major cerebellar cell types. In the absence of BG, inward invagination of GCP persists but is uncoupled from the folding of the Purkinje cell layer and the basement membrane, leading to disorganized lamination and an absence of cerebellar folia. In contrast, removing Ptpn11 in the GCP lineage by Atoh1-cre has no effect on cerebellar development, indicating that Shp2 is not cell autonomously required in GCP. Furthermore, we demonstrate that Ptpn11 interacts with Fgf8 and is essential for ERK activation in RG and nascent BG. Finally, expressing constitutively active MEK1 rescues BG formation and cerebellar foliation in Shp2-deficient cerebella. Our results demonstrate an essential role of Shp2 in BG specification via fibroblast growth factor/extracellular signal-regulated protein kinase signaling, and reveal a crucial function of BG in organizing cerebellar foliation. PMID:24431450

  6. The future of hydropower planning modeling

    Science.gov (United States)

    Haas, J.; Zuñiga, D.; Nowak, W.; Olivares, M. A.; Castelletti, A.; Thilmant, A.

    2017-12-01

    Planning the investment and operation of hydropower plants with optimization tools dates back to the 1970s. The focus used to be solely on the provision of energy. However, advances in computational capacity and solving algorithms, dynamic markets, expansion of renewable sources, and a better understanding of hydropower environmental impacts have recently led to the development of novel planning approaches. In this work, we provide a review, systematization, and trend analysis of these approaches. Further, through interviews with experts, we outline the future of hydropower planning modeling and identify the gaps towards it. We classified the found models along environmental, economic, multipurpose and technical criteria. Environmental interactions include hydropeaking mitigation, water quality protection and limiting greenhouse gas emissions from reservoirs. Economic and regulatory criteria consider uncertainties of fossil fuel prices and relicensing of water rights and power purchase agreements. Multipurpose considerations account for irrigation, tourism, flood protection and drinking water. Recently included technical details account for sedimentation in reservoirs and variable efficiencies of turbines. Additional operational considerations relate to hydrological aspects such as dynamic reservoir inflows, water losses, and climate change. Although many of the above criteria have been addressed in detail on a project-to-project basis, models remain overly simplistic for planning large power fleets. Future hydropower planning tools are expected to improve the representation of the water-energy nexus, including environmental and multipurpose criteria. Further, they will concentrate on identifying new sources of operational flexibility (e.g. through installing additional turbines and pumps) for integrating renewable energy. The operational detail will increase, potentially emphasizing variable efficiencies, storage capacity losses due to sedimentation, and the

  7. Hidroenergia 2010: International congress on small hydropower. Conference report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2010-07-01

    This conference, held in 2010 in Lausanne, Switzerland, gathered together the main stakeholders of the small hydropower community to debate about topics affecting the development of the sector, to exchange experience and to present new advances in the technological area. The two-day conference was held in a total of nine sessions, a poster session and a workshop. The first session was dedicated to water management in the Alps and covered new regulations, administrative procedures and finance issues. Contributions included a review of the present situation and the development of common guidelines to meet the challenge of conflicting technical and environmental objectives, the facilitation of small hydropower in Switzerland and the institutional frameworks involved, recent trends in small hydro project financing and the growing roles of venture capital, private equity and changing market dynamics. Finally the prospects for small hydropower in Serbia were discussed. In two parallel sessions the following topics were looked at: The promotion of small hydropower in Switzerland using various sources of water and remuneration for the power produced, small hydro in the Canton of Vaud, Switzerland, the use of karst groundwater for the underground production of power were looked at as well as the analysis of hydraulic facilities for combining pumped storage hydropower systems and wind power in Austria. The final presentation took a look at the new 'La Tzintre' hydropower project. The parallel session dealt with technical innovations and engineering solutions with presentations on the development of small diagonal turbines, the adaptation of propeller turbines to higher specific needs and the problems encountered in doing so. The use of centrifugal pumps as turbines, including a review of technology and applications were also dealt with. Two further parallel sessions looked at EU-funded projects and sustainability issues. The Sustainable Energy Europe project was

  8. Estimation of economic parameters of U.S. hydropower resources

    Energy Technology Data Exchange (ETDEWEB)

    Hall, Douglas G. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Idaho National Engineering and Environmental Lab. (INEEL); Hunt, Richard T. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Idaho National Engineering and Environmental Lab. (INEEL); Reeves, Kelly S. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Idaho National Engineering and Environmental Lab. (INEEL); Carroll, Greg R. [Idaho National Lab. (INL), Idaho Falls, ID (United States). Idaho National Engineering and Environmental Lab. (INEEL)

    2003-06-01

    Tools for estimating the cost of developing and operating and maintaining hydropower resources in the form of regression curves were developed based on historical plant data. Development costs that were addressed included: licensing, construction, and five types of environmental mitigation. It was found that the data for each type of cost correlated well with plant capacity. A tool for estimating the annual and monthly electric generation of hydropower resources was also developed. Additional tools were developed to estimate the cost of upgrading a turbine or a generator. The development and operation and maintenance cost estimating tools, and the generation estimating tool were applied to 2,155 U.S. hydropower sites representing a total potential capacity of 43,036 MW. The sites included totally undeveloped sites, dams without a hydroelectric plant, and hydroelectric plants that could be expanded to achieve greater capacity. Site characteristics and estimated costs and generation for each site were assembled in a database in Excel format that is also included within the EERE Library under the title, “Estimation of Economic Parameters of U.S. Hydropower Resources - INL Hydropower Resource Economics Database.”

  9. Small Hydropower - The comeback of small hydropower stations

    International Nuclear Information System (INIS)

    Niederhaeusern, A.

    2008-01-01

    This issue of the 'Erneuerbare Energien' (renewable energies) magazine published by the Swiss Solar Energy Society takes a look at small hydropower projects in Switzerland. In a number of interviews and articles, various topics concerning small hydropower are dealt with. First of all, an interview with Bruno Guggisberg, previously responsible for small hydro at the Swiss Federal Office of Energy, examines the potential of small hydro and the various political, technical and economic influences on such projects. Further articles provide an overview of the various types of small hydro schemes, including power generation using height differences in drinking-water and wastewater installations. As far as the components of small hydro schemes are concerned, various types of turbines and further system components that are needed are examined. A further article takes a look at the small hydro market and the market players involved. Ecological aspects and research activities are discussed in further articles. In a second interview with Martin Boelli, presently responsible for small hydropower at the Swiss Federal Office of Energy, the unused potential for the use of hydropower in Switzerland is discussed. Examples of small-scale hydro schemes are examined and the support offered by the Small Hydropower Program is discussed. Finally the question is asked, if the small hydro market in Switzerland is overheated as a result of promotion schemes such as cost-covering remuneration for electricity from renewable energy sources.

  10. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Ying-Nan P.; LaMarche, Matthew J.; Chan, Ho Man; Fekkes, Peter; Garcia-Fortanet, Jorge; Acker, Michael G.; Antonakos, Brandon; Chen, Christine Hiu-Tung; Chen, Zhouliang; Cooke, Vesselina G.; Dobson, Jason R.; Deng, Zhan; Fei, Feng; Firestone, Brant; Fodor, Michelle; Fridrich, Cary; Gao, Hui; Grunenfelder, Denise; Hao, Huai-Xiang; Jacob, Jaison; Ho, Samuel; Hsiao, Kathy; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Larrow, Jay; La Bonte, Laura R.; Lenoir, Francois; Liu, Gang; Liu, Shumei; Majumdar, Dyuti; Meyer, Matthew J.; Palermo, Mark; Perez, Lawrence; Pu, Minying; Price, Edmund; Quinn, Christopher; Shakya, Subarna; Shultz, Michael D.; Slisz, Joanna; Venkatesan, Kavitha; Wang, Ping; Warmuth, Markus; Williams, Sarah; Yang, Guizhi; Yuan, Jing; Zhang, Ji-Hu; Zhu, Ping; Ramsey, Timothy; Keen, Nicholas J.; Sellers, William R.; Stams, Travis; Fortin , Pascal D. (Novartis)

    2016-06-29

    The non-receptor protein tyrosine phosphatase SHP2, encoded by PTPN11, has an important role in signal transduction downstream of growth factor receptor signalling and was the first reported oncogenic tyrosine phosphatase1. Activating mutations of SHP2 have been associated with developmental pathologies such as Noonan syndrome and are found in multiple cancer types, including leukaemia, lung and breast cancer and neuroblastoma1, 2, 3, 4, 5. SHP2 is ubiquitously expressed and regulates cell survival and proliferation primarily through activation of the RAS–ERK signalling pathway2, 3. It is also a key mediator of the programmed cell death 1 (PD-1) and B- and T-lymphocyte attenuator (BTLA) immune checkpoint pathways6, 7. Reduction of SHP2 activity suppresses tumour cell growth and is a potential target of cancer therapy8, 9. Here we report the discovery of a highly potent (IC50 = 0.071 μM), selective and orally bioavailable small-molecule SHP2 inhibitor, SHP099, that stabilizes SHP2 in an auto-inhibited conformation. SHP099 concurrently binds to the interface of the N-terminal SH2, C-terminal SH2, and protein tyrosine phosphatase domains, thus inhibiting SHP2 activity through an allosteric mechanism. SHP099 suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models. Together, these data demonstrate that pharmacological inhibition of SHP2 is a valid therapeutic approach for the treatment of cancers.

  11. Renewable energy in the Baltic countries: the case of hydropower

    International Nuclear Information System (INIS)

    Punys, P.; Dumbrauskas, A.; Rimkus, Z.; Streimikiene, D.

    2006-01-01

    This paper analyses the use of renewable energy sources (RES) dedicated mainly for electricity generation in the Baltic countries (Estonia, Latvia and Lithuania). Hydropower sector including both large (medium) and small power plants is particularly considered. The region has very limited energy resources of its own and is heavily dependent on the import of the primary energy sources (in some way except Estonia). The main objective of energy policy of the Baltic countries is to reduce such a total dependence by favouring the use of RES. A brief description of energy sector is given, focusing on electricity generation. RES potential currently in use and to be exploited in the future, buy- back rates of the key sources are presented. The countries' target broken down according to the individual RES to meet the EU 'green' electricity directive (2001/77/CE) are presented. Small and large hydropower potential is analyzed, a general overview of hydro-plants in operation and planned schemes is provided. A particular attention is devoted to environmental and social aspects of hydropower development. The requirements of the protected areas in relation to dam construction are analyzed, an estimation of resistance to small hydropower development is shown. The environmental legislation including forbidden rivers for damming actually in force in the Baltic countries is considered; hydropower image perceptible by general public, NGOs and official environmental bodies are discussed. The causes and legal basis of the promulgation of the list of forbidden rivers are revealed. A conclusion is drawn that the contradiction between two EU legal frameworks - environmental protection and promotion of renewables, in the case of hydropower, exists. The evaluation of the quantitative impact of the forbidden rivers on small hydropower resources in Lithuania proves. the environmental legislation is one of the strictest in the European countries. (authors)

  12. PZR coordinates Shp2 Noonan and LEOPARD syndrome signaling in zebrafish and mice

    NARCIS (Netherlands)

    Paardekooper Overman, Jeroen; Yi, Jae-Sung; Bonetti, Monica; Soulsby, Matthew; Preisinger, Christian; Stokes, Matthew P; Hui, Li; Silva, Jeffrey C; Overvoorde, John; Giansanti, Piero; Heck, Albert J R; Kontaridis, Maria I; den Hertog, Jeroen; Bennett, Anton M

    Noonan syndrome (NS) is an autosomal dominant disorder caused by activating mutations in the PTPN11 gene encoding Shp2, which manifests in congenital heart disease, short stature, and facial dysmorphia. The complexity of Shp2 signaling is exemplified by the observation that LEOPARD syndrome (LS)

  13. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor

    Energy Technology Data Exchange (ETDEWEB)

    Fortanet, Jorge Garcia; Chen, Christine Hiu-Tung; Chen, Ying-Nan P.; Chen, Zhouliang; Deng, Zhan; Firestone, Brant; Fekkes, Peter; Fodor, Michelle; Fortin, Pascal D.; Fridrich, Cary; Grunenfelder, Denise; Ho, Samuel; Kang, Zhao B.; Karki, Rajesh; Kato, Mitsunori; Keen, Nick; LaBonte, Laura R.; Larrow, Jay; Lenoir, Francois; Liu, Gang; Liu, Shumei; Lombardo, Franco; Majumdar, Dyuti; Meyer, Matthew J.; Palermo, Mark; Perez, Lawrence; Pu, Minying; Ramsey, Timothy; Sellers, William R.; Shultz, Michael D.; Stams, Travis; Towler, Christopher; Wang, Ping; Williams, Sarah L.; Zhang, Ji-Hu; LaMarche, Matthew J. (Novartis)

    2016-09-08

    SHP2 is a nonreceptor protein tyrosine phosphatase (PTP) encoded by the PTPN11 gene involved in cell growth and differentiation via the MAPK signaling pathway. SHP2 also purportedly plays an important role in the programmed cell death pathway (PD-1/PD-L1). Because it is an oncoprotein associated with multiple cancer-related diseases, as well as a potential immunomodulator, controlling SHP2 activity is of significant therapeutic interest. Recently in our laboratories, a small molecule inhibitor of SHP2 was identified as an allosteric modulator that stabilizes the autoinhibited conformation of SHP2. A high throughput screen was performed to identify progressable chemical matter, and X-ray crystallography revealed the location of binding in a previously undisclosed allosteric binding pocket. Structure-based drug design was employed to optimize for SHP2 inhibition, and several new protein–ligand interactions were characterized. These studies culminated in the discovery of 6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine (SHP099, 1), a potent, selective, orally bioavailable, and efficacious SHP2 inhibitor.

  14. Gis-based procedures for hydropower potential spotting

    Energy Technology Data Exchange (ETDEWEB)

    Larentis, Dante G.; Collischonn, Walter; Tucci, Carlos E.M. [Instituto de Pesquisas Hidraulicas da UFRGS, Av. Bento Goncalves, 9500, CEP 91501-970, Caixa Postal 15029, Porto Alegre, RS (Brazil); Olivera, Francisco (Texas A and M University, Zachry Department of Civil Engineering 3136 TAMU, College Station, TX 77843-3136, US)

    2010-10-15

    The increasing demand for energy, especially from renewable and sustainable sources, spurs the development of small hydropower plants and encourages investment in new survey studies. Preliminary hydropower survey studies usually carry huge uncertainties about the technical, economic and environmental feasibility of the undeveloped potential. This paper presents a methodology for large-scale survey of hydropower potential sites to be applied in the inception phase of hydroelectric development planning. The sequence of procedures to identify hydropower sites is based on remote sensing and regional streamflow data and was automated within a GIS-based computational program: Hydrospot. The program allows spotting more potential sites along the drainage network than it would be possible in a traditional survey study, providing different types of dam-powerhouse layouts and two types (operating modes) of projects: run-of-the-river and storage projects. Preliminary results from its applications in a hydropower-developed basin in Brazil have shown Hydrospot's limitations and potentialities in giving support to the mid-to-long-term planning of the electricity sector. (author)

  15. China's rising hydropower demand challenges water sector

    NARCIS (Netherlands)

    Liu, Junguo; Zhao, Dandan; Gerbens-Leenes, Winnie; Guan, Dabo

    2015-01-01

    Demand for hydropower is increasing, yet the water footprints (WFs) of reservoirs and hydropower, and their contributions to water scarcity, are poorly understood. Here, we calculate reservoir WFs (freshwater that evaporates from reservoirs) and hydropower WFs (the WF of hydroelectricity) in China

  16. The role of hydropower in electric power integration of Asian countries

    Science.gov (United States)

    Belyaev, Lev; Savelyev, Vladimir; Chudinova, Lyudmila

    2018-01-01

    The possible role of hydropower plants in formation and operation of interstate power pools is described based on the generalization of the world experience. Peculiarities of the influence of hydropower on development of interstate electric ties in this part of the world and potential effects are showed on the example of Central and Northeast Asia.

  17. Hydropower may produce more greenhouse gases

    International Nuclear Information System (INIS)

    Kolshus, Hans H.; Folkestad, Tonje

    2002-01-01

    According to this article, dam projects in hydropower development may lead to increased emission of greenhouse gases and may create great inconveniences for the local community. Hence it is not without problems to sponsor such projects through the Clean Development Mechanism (CDM) of the Kyoto Protocol. In many countries the great era of hydroelectric development is over and the potential is now in the developing countries. The aim of the CDM is two-fold: sustainable development in the developing countries, and cheap reduction of greenhouse gas emission from developed nations. It has been agreed upon in the climate negotiations that it is the developing country receiving the investments that shall document that the projects conform to the goal of sustainable development of that country. The concept of sustain ability is a vague one, and it is a great challenge to make it more precise so that requirements may be posed on CDM projects. This is important as projects that are suitable from a climate point of view may have undesirable environmental or social effects, which may be in conflict with the goal of sustainable development. This also pertains to hydropower. It also appears that water reservoirs are not always as clean as has been assumed

  18. Refurbishment of hydropower generation plants

    International Nuclear Information System (INIS)

    Kofler, W.

    2001-01-01

    This article presents the factors taken into consideration and the methods used for the management of refurbishment work in the hydropower installations of the TUWAG - a Tyrolean hydropower company in Austria. The technical and financial advantages to be gained from refurbishment are discussed and the requirements placed on the structuring of refurbishment projects are described. Various factors such as plant operation and maintenance, increased returns through better efficiency and cost reduction through lower wear and tear and reduced risk of failure are discussed. Annexes to the article cover monitoring and measurement techniques, the simulation of mechanical and hydraulic conditions, profitability calculations and turbine management

  19. Hydropower, an integral part of Canada's climate change strategy

    International Nuclear Information System (INIS)

    Fortin, P.

    1999-01-01

    The development and implementation of a climate change policy could be among the most far-reaching environmental initiatives ever embarked upon in Canada and abroad. If Canada is to stabilize or reduce its Greenhouse Gas (GHG) emissions over the long term, a significant adjustment to Canadian industry will be required as we move away from fossil fuel-intensive and GHG producing activities. Future hydroelectric projects provide Canada with a unique opportunity to significantly reduce the costs associated with stabilizing its GHG emissions. In addition, the energy storage and dispatchability associated with hydropower can support development of other low emitting renewable resources such as wind and solar. This document discusses the potential role of hydropower as a tool to reduce emissions, recommends action to reduce barriers facing hydropower and comments on some of the policy tools available to manage Canada's GHG emissions. (author)

  20. Fuzzy rule-based model for hydropower reservoirs operation

    Energy Technology Data Exchange (ETDEWEB)

    Moeini, R.; Afshar, A.; Afshar, M.H. [School of Civil Engineering, Iran University of Science and Technology, Tehran (Iran, Islamic Republic of)

    2011-02-15

    Real-time hydropower reservoir operation is a continuous decision-making process of determining the water level of a reservoir or the volume of water released from it. The hydropower operation is usually based on operating policies and rules defined and decided upon in strategic planning. This paper presents a fuzzy rule-based model for the operation of hydropower reservoirs. The proposed fuzzy rule-based model presents a set of suitable operating rules for release from the reservoir based on ideal or target storage levels. The model operates on an 'if-then' principle, in which the 'if' is a vector of fuzzy premises and the 'then' is a vector of fuzzy consequences. In this paper, reservoir storage, inflow, and period are used as premises and the release as the consequence. The steps involved in the development of the model include, construction of membership functions for the inflow, storage and the release, formulation of fuzzy rules, implication, aggregation and defuzzification. The required knowledge bases for the formulation of the fuzzy rules is obtained form a stochastic dynamic programming (SDP) model with a steady state policy. The proposed model is applied to the hydropower operation of ''Dez'' reservoir in Iran and the results are presented and compared with those of the SDP model. The results indicate the ability of the method to solve hydropower reservoir operation problems. (author)

  1. Reevaluation of Turkey's hydropower potential and electric energy demand

    International Nuclear Information System (INIS)

    Yueksek, Omer

    2008-01-01

    This paper deals with Turkey's hydropower potential and its long-term electric energy demand predictions. In the paper, at first, Turkey's energy sources are briefly reviewed. Then, hydropower potential is analyzed and it has been concluded that Turkey's annual economically feasible hydropower potential is about 188 TWh, nearly 47% greater than the previous estimation figures of 128 TWh. A review on previous prediction models for Turkey's long-term electric energy demand is presented. In order to predict the future demand, new increment ratio scenarios, which depend on both observed data and future predictions of population, energy consumption per capita and total energy consumption, are developed. The results of 11 prediction models are compared and analyzed. It is concluded that Turkey's annual electric energy demand predictions in 2010, 2015 and 2020 vary between 222 and 242 (average 233) TWh; 302 and 356 (average 334) TWh; and 440 and 514 (average 476) TWh, respectively. A discussion on the role of hydropower in meeting long-term demand is also included in the paper and it has been predicted that hydropower can meet 25-35% of Turkey's electric energy demand in 2020

  2. 水电开发管理中激励机制对于合作关系的作用机理研究%Influence of incentive mechanism on partnership in hydropower development management in China

    Institute of Scientific and Technical Information of China (English)

    姚迎; 唐文哲; 强茂山; 陆佑楣; 彭青峰

    2012-01-01

    我国水电企业如何与众多利益相关组织合作以顺利实现项目目标是需要解决的关键问题.基于我国水电开发现状的调研,研究了伙伴关系管理模式和激励机制的应用现状和作用机理.结果显示,水电企业与不同组织的合作重要程度和工作联系紧密程度呈正相关,且合作表现与合作重要程度具有一致性;建立合作伙伴关系能够为企业提供可持续发展空间、帮助企业树立良好形象、整合产业链资源、提高决策价值和加强组织间学习等效益;激励可以成为继信任之外另一个维持伙伴关系的重要手段,即通过合理的利益分配机制,能够减少项目参与组织间的目标差异性,从而使得伙伴关系得以建立和维系.%For China' s hydropower enterprises,the key issue is how to cooperate with various stakeholders so as to achieve project participants ' objectives.Based on the survey of the current situation of hydropower development in China,the application and influence of partnership mode and incentive mechanism are studied.The results show that the hydropower enterprises ' partnership degree with various stakeholders has a positive correlation with the degree of their business relation,and their partnership performance agrees with the partnership degree.The partnership can bring substantial benefits for the hydropower enterprises such as space for sustainable development,establishment of good corporate image,integration of business resources,promotion of decision-making value and enhancement of organizational learning.Besides the trust mechanism,the incentive mechanism provides another important way to promote the partnership,that is,the rational benefit distribution mechanism can effectively reduce the objective differences among project participants so as to establish and maintain their partnership.

  3. Assessing residual hydropower potential of the La Plata Basin accounting for future user demands

    Directory of Open Access Journals (Sweden)

    I. Popescu

    2012-08-01

    Full Text Available La Plata Basin is shared by five countries (Argentina, Bolivia, Brazil, Paraguay and Uruguay, which have fast growing economies in South America. These countries need energy for their sustainable development; hence, hydropower can play a very important role as a renewable clean source of energy. This paper presents an analysis of the current hydropower production and electricity demand in La Plata Basin (LPB, and it analyses the maximum and residual hydropower potential of the basin for a horizon of 30 yr (i.e. year 2040. Current hydropower production is estimated based on historical available data, while future energy production is deduced from the available water in the catchment (estimated based on measured hydrographs of the past years, whereas electricity demand is assessed by correlating existing electricity demand with the estimated population growth and economic development. The maximum and residual hydropower potential of the basin were assessed for the mean annual flows of the present hydrological regime (1970–2000 and topographical characteristics of the area.

    Computations were performed using an integrated GIS environment called VAPIDRO-ASTE released by the Research on Energy System (Italy. The residual hydropower potential of the basin is computed considering first that the water supply needs for population, industry and agriculture are served, and then hydropower energy is produced. The calculated hydropower production is found to be approximately half of the estimated electricity demand, which shows that there is a need to look for other sources of energy in the future.

  4. Assessing residual hydropower potential of the La Plata Basin accounting for future user demands

    Science.gov (United States)

    Popescu, I.; Brandimarte, L.; Perera, M. S. U.; Peviani, M.

    2012-08-01

    La Plata Basin is shared by five countries (Argentina, Bolivia, Brazil, Paraguay and Uruguay), which have fast growing economies in South America. These countries need energy for their sustainable development; hence, hydropower can play a very important role as a renewable clean source of energy. This paper presents an analysis of the current hydropower production and electricity demand in La Plata Basin (LPB), and it analyses the maximum and residual hydropower potential of the basin for a horizon of 30 yr (i.e. year 2040). Current hydropower production is estimated based on historical available data, while future energy production is deduced from the available water in the catchment (estimated based on measured hydrographs of the past years), whereas electricity demand is assessed by correlating existing electricity demand with the estimated population growth and economic development. The maximum and residual hydropower potential of the basin were assessed for the mean annual flows of the present hydrological regime (1970-2000) and topographical characteristics of the area. Computations were performed using an integrated GIS environment called VAPIDRO-ASTE released by the Research on Energy System (Italy). The residual hydropower potential of the basin is computed considering first that the water supply needs for population, industry and agriculture are served, and then hydropower energy is produced. The calculated hydropower production is found to be approximately half of the estimated electricity demand, which shows that there is a need to look for other sources of energy in the future.

  5. DOE Hydropower Program biennial report 1996-1997 (with an updated annotated bibliography)

    Energy Technology Data Exchange (ETDEWEB)

    Rinehart, B.N.; Francfort, J.E.; Sommers, G.L. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States); Cada, G.F.; Sale, M.J. [Oak Ridge National Lab., TN (United States)

    1997-06-01

    This report, the latest in a series of biennial Hydropower Program reports sponsored by the US Department of Energy, summarizes the research and development and technology transfer activities of fiscal years 1996 and 1997. The report discusses the activities in the six areas of the hydropower program: advanced hydropower turbine systems; environmental research; hydropower research and development; renewable Indian energy resources; resource assessment; and technology transfer. The report also includes an annotated bibliography of reports pertinent to hydropower, written by the staff of the Idaho National Engineering and Environmental Laboratory, Oak Ridge National Laboratory, Federal and state agencies, cities, metropolitan water districts, irrigation companies, and public and independent utilities. Most reports are available from the National Technical Information Service.

  6. Geothermal and hydropower production in Iceland

    International Nuclear Information System (INIS)

    Rosa, D.J.

    1993-01-01

    This paper analyzes the impact of current and future development of geothermal and hydropower production on the economy of Iceland. Natural conditions in Iceland favor the increased utilization and development of both of these abundant power sources. The mean surface run-off in Iceland is about 50 l/s/km 2 (liters per second per square kilometer), with a large part of the country consisting of a plateau more than 400 meters above sea level. More than half of the country is above 500 meters above sea level. ne technically harnessable hydropower potential is estimated at 64 TWh/year (terawatthours per year), of which 30 TWh/year is considered economically and environmentally harnessable. In addition, Iceland has abundant geothermal energy sources. A quarter of the entire country is a volcanic area. Keeping in mind that geothermal resources are not strictly renewable, it is estimated that the potential power production from this source is 20 TWh/year. Present utilization of these two resources totals only 4.2 TWh/year, or only about 8% of Iceland's aggregate potential. There are many issues facing Iceland today as it considers development opportunities utilizing both of these abundant power supplies. This paper will first consider the technical aspects of both hydropower and geothermal power production in Iceland. Then, the economic consequences of alternative utilization of these energy sources will be evaluated. The first alternative to be considered will be the direct export of power by HVDC submarine cable to other countries, such as Scotland or the United Kingdom. Iceland could, as a second alterative, concentrate its efforts on bringing in energy intensive industries into the country

  7. Hydropower Baseline Cost Modeling, Version 2

    Energy Technology Data Exchange (ETDEWEB)

    O' Connor, Patrick W. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    Recent resource assessments conducted by the United States Department of Energy have identified significant opportunities for expanding hydropower generation through the addition of power to non-powered dams and on undeveloped stream-reaches. Additional interest exists in the powering of existing water resource infrastructure such as conduits and canals, upgrading and expanding existing hydropower facilities, and the construction new pumped storage hydropower. Understanding the potential future role of these hydropower resources in the nation’s energy system requires an assessment of the environmental and techno-economic issues associated with expanding hydropower generation. To facilitate these assessments, this report seeks to fill the current gaps in publically available hydropower cost estimating tools that can support the national-scale evaluation of hydropower resources.

  8. Optimization of Mangala Hydropower Station, Pakistan, using Optimization Techniques

    Directory of Open Access Journals (Sweden)

    Zaman Muhammad

    2017-01-01

    Full Text Available Hydropower generation is one of the key element in the economy of a country. The present study focusses on the optimal electricity generation from the Mangla reservoir in Pakistan. A mathematical model has been developed for the Mangla hydropower station and particle swarm and genetic algorithm optimization techniques were applied at this model for optimal electricity generation. Results revealed that electricity production increases with the application of optimization techniques at the proposed mathematical model. Genetic Algorithm can produce maximum electricity than Particle swarm optimization but the time of execution of particle swarm optimization is much lesser than the Genetic algorithm. Mangla hydropower station can produce up to 59*109 kWh electricity by using the flows optimally than 47*108 kWh production from traditional methods.

  9. Regulatory Approaches for Adding Capacity to Existing Hydropower Facilities

    Energy Technology Data Exchange (ETDEWEB)

    Levine, Aaron L. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Curtis, Taylor L. [National Renewable Energy Laboratory (NREL), Golden, CO (United States); Kazerooni, Borna [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2017-10-24

    In 2015, hydroelectric generation accounted for more than 6 percent of total net electricity generation in the United States and 46 percent of electricity generation from all renewables. The United States has considerable hydroelectric potential beyond what is already being developed. Nearly 7 GW of this potential is found by adding capacity to existing hydropower facilities. To optimize the value of hydroelectric generation, the U.S. Department of Energy's Hydropower Vision Study highlights the importance of adding capacity to existing facilities. This report provides strategic approaches and considerations for Federal Energy Regulatory Commission licensed and exempt hydropower facilities seeking to increase generation capacity, which may include increases from efficiency upgrades. The regulatory approaches reviewed for this report include capacity and non-capacity amendments, adding capacity during relicensing, and adding capacity when converting a license to a 10-MW exemption.

  10. Shp2 in Forebrain Neurons Regulates Synaptic Plasticity, Locomotion, and Memory Formation in Mice

    Science.gov (United States)

    Kusakari, Shinya; Saitow, Fumihito; Ago, Yukio; Shibasaki, Koji; Sato-Hashimoto, Miho; Matsuzaki, Yasunori; Kotani, Takenori; Murata, Yoji; Hirai, Hirokazu; Matsuda, Toshio; Suzuki, Hidenori

    2015-01-01

    Shp2 (Src homology 2 domain-containing protein tyrosine phosphatase 2) regulates neural cell differentiation. It is also expressed in postmitotic neurons, however, and mutations of Shp2 are associated with clinical syndromes characterized by mental retardation. Here we show that conditional-knockout (cKO) mice lacking Shp2 specifically in postmitotic forebrain neurons manifest abnormal behavior, including hyperactivity. Novelty-induced expression of immediate-early genes and activation of extracellular-signal-regulated kinase (Erk) were attenuated in the cerebral cortex and hippocampus of Shp2 cKO mice, suggestive of reduced neuronal activity. In contrast, ablation of Shp2 enhanced high-K+-induced Erk activation in both cultured cortical neurons and synaptosomes, whereas it inhibited that induced by brain-derived growth factor in cultured neurons. Posttetanic potentiation and paired-pulse facilitation were attenuated and enhanced, respectively, in hippocampal slices from Shp2 cKO mice. The mutant mice also manifested transient impairment of memory formation in the Morris water maze. Our data suggest that Shp2 contributes to regulation of Erk activation and synaptic plasticity in postmitotic forebrain neurons and thereby controls locomotor activity and memory formation. PMID:25713104

  11. A Holistic Framework for Environmental Flows Determination in Hydropower Contexts

    Energy Technology Data Exchange (ETDEWEB)

    McManamay, Ryan A [ORNL; Bevelhimer, Mark S [ORNL

    2013-05-01

    Among the ecological science community, the consensus view is that the natural flow regime sustains the ecological integrity of river systems. This prevailing viewpoint by many environmental stakeholders has progressively led to increased pressure on hydropower dam owners to change plant operations to affect downstream river flows with the intention of providing better conditions for aquatic biological communities. Identifying the neccessary magnitude, frequency, duration, timing, or rate of change of stream flows to meet ecological needs in a hydropower context is challenging because the ecological responses to changes in flows may not be fully known, there are usually a multitude of competing users of flow, and implementing environmental flows usually comes at a price to energy production. Realistically, hydropower managers must develop a reduced set of goals that provide the most benefit to the identified ecological needs. As a part of the Department of Energy (DOE) Water Power Program, the Instream Flow Project (IFP) was carried out by Oak Ridge National Laboratory (ORNL), Pacific Northwest National Laboratory (PNNL), and Argon National Laboratory (ANL) as an attempt to develop tools aimed at defining environmental flow needs for hydropower operations. The application of these tools ranges from national to site-specific scales; thus, the utility of each tool will depend on various phases of the environmental flow process. Given the complexity and sheer volume of applications used to determine environmentally acceptable flows for hydropower, a framework is needed to organize efforts into a staged process dependent upon spatial, temporal, and functional attributes. By far, the predominant domain for determining environmental flows related to hydropower is within the Federal Energy Regulatory Commission (FERC) relicensing process. This process can take multiple years and can be very expensive depending on the scale of each hydropower project. The utility of such a

  12. Pharmacological Targeting SHP-1-STAT3 Signaling Is a Promising Therapeutic Approach for the Treatment of Colorectal Cancer

    Directory of Open Access Journals (Sweden)

    Li-Ching Fan

    2015-09-01

    Full Text Available STAT3 activation is associated with poor prognosis in human colorectal cancer (CRC. Our previous data demonstrated that regorafenib (Stivarga is a pharmacological agonist of SH2 domain-containing phosphatase 1 (SHP-1 that enhances SHP-1 activity and induces apoptosis by targeting STAT3 signals in CRC. This study aimed to find a therapeutic drug that is more effective than regorafenib for CRC treatment. Here, we showed that SC-43 was more effective than regorafenib at inducing apoptosis in vitro and suppressing tumorigenesis in vivo. SC-43 significantly increased SHP-1 activity, downregulated p-STAT3Tyr705 level, and induced apoptosis in CRC cells. An SHP-1 inhibitor or knockdown of SHP-1 by siRNA both significantly rescued the SC-43–induced apoptosis and decreased p-STAT3Tyr705 level. Conversely, SHP-1 overexpression increased the effects of SC-43 on apoptosis and p-STAT3Tyr705 level. These data suggest that SC-43–induced apoptosis mediated through the loss of p-STAT3Tyr705 was dependent on SHP-1 function. Importantly, SC-43–enhanced SHP-1 activity was because of the docking potential of SC-43, which relieved the autoinhibited N-SH2 domain of SHP-1 and inhibited p-STAT3Tyr705 signals. Importantly, we observed that a significant negative correlation existed between SHP-1 and p-STAT3Tyr705expression in CRC patients (P = .038. Patients with strong SHP-1 and weak p-STAT3Tyr705 expression had significantly higher overall survival compared with patients with weak SHP-1 and strong p-STAT3Tyr705 expression (P = .029. In conclusion, SHP-1 is suitable to be a useful prognostic marker and a pharmacological target for CRC treatment. Targeting SHP-1-STAT3 signaling by SC-43 may serve as a promising pharmacotherapy for CRC.

  13. Hydropower, an energy source whose time has come again

    Science.gov (United States)

    1980-01-01

    Recent price increases in imported oil demonstrate the urgency for the U.S. to rapidly develop its renewable resources. One such renewable resource for which technology is available now is hydropower. Studies indicate that hydropower potential, particularly at existing dam sites, can save the county hundreds of thousands of barrels of oil per day. But problems and constraints-economic, environmental, institutional, and operational-limit is full potential. Federal programs have had little impact on helping to bring hydro projects on line. Specifically, the Department of Energy's Small Hydro Program could do more to overcome hydro constraints and problems through an effective outreach program and more emphasis on demonstration projects.

  14. Simulation and Modeling Capability for Standard Modular Hydropower Technology

    Energy Technology Data Exchange (ETDEWEB)

    Stewart, Kevin M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Smith, Brennan T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeNeale, Scott T. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Bevelhimer, Mark S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Pries, Jason L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Burress, Timothy A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Kao, Shih-Chieh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mobley, Miles H. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Lee, Kyutae [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Curd, Shelaine L. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Tsakiris, Achilleas [Univ. of Tennessee, Knoxville, TN (United States); Mooneyham, Christian [Univ. of Tennessee, Knoxville, TN (United States); Papanicolaou, Thanos [Univ. of Tennessee, Knoxville, TN (United States); Ekici, Kivanc [Univ. of Tennessee, Knoxville, TN (United States); Whisenant, Matthew J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Welch, Tim [US Department of Energy, Washington, DC (United States); Rabon, Daniel [US Department of Energy, Washington, DC (United States)

    2017-08-01

    Grounded in the stakeholder-validated framework established in Oak Ridge National Laboratory’s SMH Exemplary Design Envelope Specification, this report on Simulation and Modeling Capability for Standard Modular Hydropower (SMH) Technology provides insight into the concepts, use cases, needs, gaps, and challenges associated with modeling and simulating SMH technologies. The SMH concept envisions a network of generation, passage, and foundation modules that achieve environmentally compatible, cost-optimized hydropower using standardization and modularity. The development of standardized modeling approaches and simulation techniques for SMH (as described in this report) will pave the way for reliable, cost-effective methods for technology evaluation, optimization, and verification.

  15. Memorandum of Understanding for Hydropower Two-Year Progress Report

    Energy Technology Data Exchange (ETDEWEB)

    None

    2012-04-01

    On March 24, 2010, the Department of the Army (DOA) through the U.S. Army Corps of Engineers (USACE or Corps), the Department of Energy, and the Department of the Interior signed the Memorandum of Understanding (MOU) for Hydropower. The purpose of the MOU is to “help meet the nation’s needs for reliable, affordable, and environmentally sustainable hydropower by building a long-term working relationship, prioritizing similar goals, and aligning ongoing and future renewable energy development efforts.” This report documents efforts so far.

  16. An empirical analysis of the hydropower portfolio in Pakistan

    International Nuclear Information System (INIS)

    Siddiqi, Afreen; Wescoat, James L.; Humair, Salal; Afridi, Khurram

    2012-01-01

    The Indus Basin of Pakistan with 800 hydropower project sites and a feasible hydropower potential of 60 GW, 89% of which is undeveloped, is a complex system poised for large-scale changes in the future. Motivated by the need to understand future impacts of hydropower alternatives, this study conducted a multi-dimensional, empirical analysis of the full hydropower portfolio. The results show that the full portfolio spans multiple scales of capacity from mega (>1000 MW) to micro (<0.1 MW) projects with a skewed spatial distribution within the provinces, as well as among rivers and canals. Of the total feasible potential, 76% lies in two (out of six) administrative regions and 68% lies in two major rivers (out of more than 125 total channels). Once projects currently under implementation are commissioned, there would be a five-fold increase from a current installed capacity of 6720 MW to 36759 MW. It is recommended that the implementation and design decisions should carefully include spatial distribution and environmental considerations upfront. Furthermore, uncertainties in actual energy generation, and broader hydrological risks due to expected climate change effects should be included in the current planning of these systems that are to provide service over several decades into the future. - Highlights: ► Pakistan has a hydropower potential of 60 GW distributed across 800 projects. ► Under-development projects will realize 36.7 GW of this potential by 2030. ► Project locations are skewed towards some sub-basins and provinces. ► Project sizes are very diverse and have quite limited private sector ownership. ► Gaps in data prevent proper risk assessment for Pakistan's hydropower development.

  17. Dovitinib Acts As a Novel Radiosensitizer in Hepatocellular Carcinoma by Targeting SHP-1/STAT3 Signaling

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Chao-Yuan [Department of Oncology, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan (China); Department of Radiological Technology, Yuanpei University, Hsinchu, Taiwan (China); Tai, Wei-Tien [Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan (China); National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan (China); Wu, Szu-Yuan [Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Taiwan (China); Department of Radiation Oncology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan (China); Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan (China); Department of Biotechnology, Hungkuang University, Taichung, Taiwan (China); Shih, Chih-Ting; Chen, Min-Hsuan; Tsai, Ming-Hsien [Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan (China); Kuo, Chiung-Wen [Department of Medical Imaging and Radiological Technology, Yuanpei University of Medical Technology, Hsinchu, Taiwan (China); Shiau, Chung-Wai [Institute of Biopharmaceutical Sciences, National Yang-Ming University, Taipei, Taiwan (China); Hung, Man-Hsin, E-mail: cindybeaty@gmail.com [Division of Medical Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan (China); Division of Hematology and Oncology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan (China); Program in Molecular Medicine, School of Life Science, National Yang-Ming University, Taipei, Taiwan (China); School of Medicine, National Yang-Ming University, Taipei, Taiwan (China); Chen, Kuen-Feng, E-mail: kfchen1970@ntu.edu.tw [Department of Medical Research, National Taiwan University Hospital, Taipei, Taiwan (China); National Center of Excellence for Clinical Trial and Research, National Taiwan University Hospital, Taipei, Taiwan (China)

    2016-06-01

    Purpose: Hepatocellular carcinoma (HCC) is among the most lethal human malignancies, and curative therapy is not an option for most patients. There is growing interest in the potential benefit of combining targeted therapies with radiation therapy (RT). This study aimed to characterize the efficacy and mechanism of an investigational drug, dovitinib, used in combination with RT. Methods and Materials: HCC cell lines (PLC5, Hep3B, SK-Hep1, HA59T, and Huh-7) were treated with dovitinib, RT, or both, and apoptosis and signal transduction were analyzed. Results: Dovitinib treatment resulted in Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1)-mediated downregulation of p-STAT3 and promoted potent apoptosis of HCC cells. Ectopic expression of STAT3, or inhibition of SHP-1, diminished the effects of dovitinib on HCC cells. By ectopic expression and purified recombinant proteins of various mutant forms of SHP-1, the N-SH2 domain of SHP-1 was found to be required for dovitinib treatment. Overexpression of STAT3 or catalytic-dead mutant SHP-1 restored RT-induced reduction of HCC cell survival. Conversely, ectopic expression of SHP-1 or activation of SHP-1 by dovitinib enhanced the effects of RT against HCC in vitro and in vivo. Conclusions: SHP-1/STAT3 signaling is critically associated with the radiosensitivity of HCC cells. Combination therapy with RT and the SHP-1 agonist, such as dovitinib, resulted in enhanced in vitro and in vivo anti-HCC effects.

  18. Dovitinib Acts As a Novel Radiosensitizer in Hepatocellular Carcinoma by Targeting SHP-1/STAT3 Signaling

    International Nuclear Information System (INIS)

    Huang, Chao-Yuan; Tai, Wei-Tien; Wu, Szu-Yuan; Shih, Chih-Ting; Chen, Min-Hsuan; Tsai, Ming-Hsien; Kuo, Chiung-Wen; Shiau, Chung-Wai; Hung, Man-Hsin; Chen, Kuen-Feng

    2016-01-01

    Purpose: Hepatocellular carcinoma (HCC) is among the most lethal human malignancies, and curative therapy is not an option for most patients. There is growing interest in the potential benefit of combining targeted therapies with radiation therapy (RT). This study aimed to characterize the efficacy and mechanism of an investigational drug, dovitinib, used in combination with RT. Methods and Materials: HCC cell lines (PLC5, Hep3B, SK-Hep1, HA59T, and Huh-7) were treated with dovitinib, RT, or both, and apoptosis and signal transduction were analyzed. Results: Dovitinib treatment resulted in Src homology region 2 (SH2) domain-containing phosphatase 1 (SHP-1)-mediated downregulation of p-STAT3 and promoted potent apoptosis of HCC cells. Ectopic expression of STAT3, or inhibition of SHP-1, diminished the effects of dovitinib on HCC cells. By ectopic expression and purified recombinant proteins of various mutant forms of SHP-1, the N-SH2 domain of SHP-1 was found to be required for dovitinib treatment. Overexpression of STAT3 or catalytic-dead mutant SHP-1 restored RT-induced reduction of HCC cell survival. Conversely, ectopic expression of SHP-1 or activation of SHP-1 by dovitinib enhanced the effects of RT against HCC in vitro and in vivo. Conclusions: SHP-1/STAT3 signaling is critically associated with the radiosensitivity of HCC cells. Combination therapy with RT and the SHP-1 agonist, such as dovitinib, resulted in enhanced in vitro and in vivo anti-HCC effects.

  19. Association of 3BP2 with SHP-1 regulates SHP-1-mediated production of TNF-α in RBL-2H3 cells.

    Science.gov (United States)

    Chihara, Kazuyasu; Nakashima, Kenji; Takeuchi, Kenji; Sada, Kiyonao

    2011-12-01

    Adaptor protein 3BP2, a c-Abl Src homology 3 (SH3) domain-binding protein, is tyrosine phosphorylated and positively regulates mast cell signal transduction after the aggregation of the high affinity IgE receptor (FcεRI). Overexpression of the Src homology 2 (SH2) domain of 3BP2 results in the dramatic suppression of antigen-induced degranulation in rat basophilic leukemia RBL-2H3 cells. Previously, a linker for activation of T cells (LAT) was identified as one of the 3BP2 SH2 domain-binding protein. In this report, to further understand the functions of 3BP2 in FcεRI-mediated activation of mast cell, we explored the protein that associates with the SH2 domain of 3BP2 and found that SH2 domain-containing phosphatase-1 (SHP-1) inducibly interacts with the SH2 domain of 3BP2 after the aggregation of FcεRI. The phosphorylation of Tyr(564) in the carboxy (C)-terminal tail region of SHP-1 is required for the direct interaction of SHP-1 to the SH2 domain of 3BP2. The expression of the mutant form of SHP-1 which was unable to interact with 3BP2 resulted in the significant reduction in SHP-1-mediated tumor necrosis factor-α (TNF-α) production without any effects on the degranulation in antigen-stimulated RBL-2H3 cells. These findings suggest that 3BP2 directly interacts with Tyr(564) -phosphorylated form of SHP-1 and positively regulates the function of SHP-1 in FcεRI-mediated signaling in mast cells. © 2011 The Authors. Journal compilation © 2011 by the Molecular Biology Society of Japan/Blackwell Publishing Ltd.

  20. The impacts of climate change on a Norwegian high-head hydropower plant

    Energy Technology Data Exchange (ETDEWEB)

    Chernet, Haregewoin Haile; Alfredsen, Knut; Killintveit, Aanund

    2010-07-01

    Full text: Norway relies on hydropower for 99 percent of the electricity production and thus Hydropower is important for Norway today and in the future energy system. The work presented in this paper shows how a high-head hydropower system in Norway will be affected in the future climate. The Aurland Hydropower system, operated by E-Co Vannkraft, Norway is the test case for the study. The Aurland hydropower system has many reservoirs and transfer systems and is considered to be one of the complex systems in Norway, but also a typical example of a Norwegian high head system. The nMAG Hydropower simulation model, which has been developed at the Norwegian Hydro technical Laboratory, is used to simulate the hydropower system. Historical and future inflow series were transposed from the neighbouring catchment Flaamselvi using scaling based on area and specific runoff, as there is no discharge station in Aurland catchment with long unregulated inflow series to set up the model and to be used for developing future climate scenarios. To generate the future inflow series for the analysis, the HBV hydrological model is calibrated for the Flaamselvi catchment. The model is then used to generate future inflow series of using the Hadley GCM (HADAm3) and A2, B2 climate scenarios. The operation of the hydropower system is then simulated for the period 2071 -2100 to see how future power production is affected by the change in the inflow conditions. The HBV model is also used to see how snow accumulation will be affected in the future as snow melt is important for Norwegian reservoir and hydropower systems. The Hydrologic scenarios under climate change imply an average increase in runoff for the system. Snow accumulation will decrease with sooner snow melt and more winter precipitation as rain. The hydropower simulation results show that associated with the increase in runoff there is an increase in energy generation with 10-20% under the current reservoir operation strategies

  1. Greenhouse gas emissions of hydropower in the Mekong River Basin

    Science.gov (United States)

    Räsänen, Timo A.; Varis, Olli; Scherer, Laura; Kummu, Matti

    2018-03-01

    The Mekong River Basin in Southeast Asia is undergoing extensive hydropower development, but the magnitudes of related greenhouse gas emissions (GHG) are not well known. We provide the first screening of GHG emissions of 141 existing and planned reservoirs in the basin, with a focus on atmospheric gross emissions through the reservoir water surface. The emissions were estimated using statistical models that are based on global emission measurements. The hydropower reservoirs (119) were found to have an emission range of 0.2-1994 kg CO2e MWh-1 over a 100 year lifetime with a median of 26 kg CO2e MWh-1. Hydropower reservoirs facilitating irrigation (22) had generally higher emissions reaching over 22 000 kg CO2e MWh-1. The emission fluxes for all reservoirs (141) had a range of 26-1813 000 t CO2e yr-1 over a 100 year lifetime with a median of 28 000 t CO2e yr-1. Altogether, 82% of hydropower reservoirs (119) and 45% of reservoirs also facilitating irrigation (22) have emissions comparable to other renewable energy sources (equalling even the emission from fossil fuel power plants (>380 kg CO2e MWh-1). These results are tentative and they suggest that hydropower in the Mekong Region cannot be considered categorically as low-emission energy. Instead, the GHG emissions of hydropower should be carefully considered case-by-case together with the other impacts on the natural and social environment.

  2. Damages and methods for reparation; Hydropower structures; Skador och reparationsmetoder

    Energy Technology Data Exchange (ETDEWEB)

    Sandstroem, Tomas

    2008-10-15

    As the focus of the Swedish Hydropower Industry shifted from the developing phase of the 20th century to the present phase of managing and maintenance of the hydropower plants and the adherent structures knowledge regarding issues concerning repair work and degradation processes of concrete has become truly important. Hydropower structures are submitted to live loads (for example caused by ice, water, snow and wind) and physical attacks such as Freeze/thaw, leaching and erosion (abrasion and cavitation). Hydropower structures are also submitted to chemical and electro chemical attacks like ASR and corrosion of the reinforcement bars. All of the mentioned processes have a negative affect on concrete structures service life. As it is today the Hydropower Industry possesses a rather high degree of knowledge concerning principal repair and strengthening techniques like shotcreting and grouting. The purpose of this report is (1) to point out the Swedish Hydropower Industry's need for extensive knowledge regarding overlays and toppings and (2) the potential advantages of overlays and toppings as repair techniques with respect to hydropower environments and the corresponding degradation processes acting on those structures. The performance of repairing a concrete structure using overlays or toppings is principally executed by the removal (totally or partially) of the damaged concrete surface, afterwards a new concrete overlay or topping is applied. The overlay must be able to withstand the live loads and the physical, chemical and electro-chemical attacks that are acting on the structure. The overlay is also required to co-operate with, and protect, the host material for a very long time. This report deals with the most common types of physical and chemical processes that are acting in Hydropower environments and the damages that they are causing concrete structures. Some of the common principal repair techniques that can be used when repairing the damaged concrete

  3. DOE Hydropower Program biennial report 1990--1991 (with updated annotated bibliography)

    Energy Technology Data Exchange (ETDEWEB)

    Chappell, J.R.; Rinehart, B.N.; Sommers, G.L. (Idaho National Engineering Lab., Idaho Falls, ID (United States)); Sale, M.J. (Oak Ridge National Lab., TN (United States))

    1991-07-01

    This report summarizes the activities of the US Department of Energy's (DOE) Hydropower Program for fiscal years 1990 and 1991, and provides an annotated bibliography of research, engineering, operations, regulations, and costs of projects pertinent to hydropower development. The Hydropower Program is organized as follows: background (including Technology Development and Engineering Research and Development); Resource Assessment; National Energy Strategy; Technology Transfer; Environmental Research; and, the bibliography discusses reports written by both private and non-Federal Government sectors. Most reports are available from the National Technical Information Service. 5 figs., 2 tabs.

  4. Modelling and controlling hydropower plants

    CERN Document Server

    Munoz-Hernandez, German Ardul; Jones, Dewi Ieuan

    2013-01-01

    Hydroelectric power stations are a major source of electricity around the world; understanding their dynamics is crucial to achieving good performance.  Modelling and Controlling Hydropower Plants discusses practical and well-documented cases of modelling and controlling hydropower station modelling and control, focussing on a pumped storage scheme based in Dinorwig, North Wales.  Single-input-single-output and multiple-input-multiple-output models, which cover the linear and nonlinear characteristics of pump-storage hydroelectric power stations, are reviewed. The most important dynamic features are discussed, and the verification of these models by hardware in the loop simulation is described. To show how the performance of a pump-storage hydroelectric power station can be improved, classical and modern controllers are applied to simulated models of the Dinorwig power plant. These include PID, fuzzy approximation, feed-forward and model-based predictive control with linear and hybrid prediction models. Mod...

  5. Hydropower and Environmental Sustainability - HydroES 2016 Report on the Conference held by SHF in Grenoble on March 16-17, 2016

    International Nuclear Information System (INIS)

    Barillier, Agnes; Caignaert, Guy; Gouraud, Veronique; Ramos, Maria-Helena; Roult, Didier; Viollet, Pierre-Louis

    2016-01-01

    Hydropower is an important source of renewable energy for electrical production in Europe and throughout the world. Being flexible and allowing energy storage, it also facilitates the development of intermittent energy in electricity systems. The development, operation and maintenance of hydropower production are closely related to growing concerns on environment sustainability, climate change mitigation and meeting societal needs for energy. Reliable and efficient hydropower facilities can improve hydropower performance and the environmental acceptability of new projects when they are also planned to protect the environment in which they operate. This document presents a synthesis report of the international conference HydroES 2016 - Hydropower and Environmental Sustainability, organized by SHF and hosted by INP ENSE3, in Grenoble, on 16-17 March 2016. It shows that the scientific community and the hydropower industry are committed to assessing environment and social impacts of hydropower and are proactive towards a sustainable future. (authors)

  6. Technical basis to describe and document the use of the E-600 and SHP-380 detector

    International Nuclear Information System (INIS)

    Hensley, J.R.

    1997-06-01

    This technical basis document describes and documents the parameters under which the Eberline E-600 ratemeter and the associated SHP-380 detector can be operated to quantify alpha and beta contamination levels. 3 refs., 3 tabs

  7. The theory and practice of 100 pilot SHP-based rural electrification counties in China

    Energy Technology Data Exchange (ETDEWEB)

    Luo Gaorong [Organization of the United Nations, Beijing (China). International Centre of Small Hydroelectric Power Plants

    1995-07-01

    This document presents the theory and practice of 100 pilot small hydroelectric power plants (SHP) based rural electrification counties in China. The document reports the research contents, methodology and results, and the pilot benefit analysis and evaluation.

  8. Pumped Storage and Potential Hydropower from Conduits

    Energy Technology Data Exchange (ETDEWEB)

    none,

    2015-02-25

    Th is Congressional Report, Pumped Storage Hydropower and Potential Hydropower from Conduits, addresses the technical flexibility that existing pumped storage facilities can provide to support intermittent renewable energy generation. This study considered potential upgrades or retrofit of these facilities, the technical potential of existing and new pumped storage facilities to provide grid reliability benefits, and the range of conduit hydropower opportunities available in the United States.

  9. The multipurpose water use of hydropower reservoir: the SHARE concept

    International Nuclear Information System (INIS)

    Branche, E.

    2017-01-01

    Multipurpose hydropower reservoirs are designed and/or operated to provide services beyond electricity generation, such as water supply, flood and drought management, irrigation, navigation, fisheries, environmental services and recreational activities, etc. While these objectives (renewable and power services, water quantity management, ecosystem services, economic growth and local livelihoods) can conflict at times, they are also often complementary. Although there are no universal solutions, there are principles that can be shared and adapted to local contexts. Indeed the development and/or operation of such multipurpose hydropower reservoirs to reach sustainable water management should rely on the following principles: shared vision, shared resource, shared responsibilities, shared rights and risks, shared costs and benefits. These principles and acknowledgement of joint sharing among all the stakeholders are essential to successful development and management of multipurpose hydropower reservoirs, and should frame all phases from early stage to operation. The SHARE concept also gives guidance. Based on 12 worldwide case studies of multipurpose hydropower reservoirs, the SHARE concept was developed and proposed as a solution to address this issue. A special focus will be presented on the Durance-Verdon Rivers in France. (author)

  10. Using ecological hydrograph for determination of flow remaining in sections of reduced flow of small hydropower plants; Uso do hidrograma ecologico para determinacao de vazoes remanescentes em trechos de vazao reduzida de pequenas centrais hidreletricas

    Energy Technology Data Exchange (ETDEWEB)

    Oliveira, Samuel Torres de; Dzedzej, Maira; Batista, Thiago Roberto; Silva, Benedito [IX Consultoria e Representacoes Ltda, Itajuba, MG (Brazil); Universidade Federal de Itajuba (UNIFEI), MG (Brazil); Santos, Afonso Henrique Moreira [MS Consultoria Ltda, Itajuba, MG (Brazil); Universidade Federal de Itajuba (UNIFEI), MG (Brazil)

    2010-07-01

    The rivers have been providing the basis for socio-economic development. Water is used for many different purposes, domestic, industrial, agricultural and power generation, in addition to providing navigation routes, and food resources for fisheries. The installation of hydroelectric centers which cause diversion of the river, leads to the creation of a reduced flow section. The residual flow proposed for this area should respect the characteristics of hydrological, morphological, chemical and ecological state of the river, ensuring their multiple uses. This work's purpose is the determination of a flow, or a set of adequate minimum flows for the reduced flow section of Small Hydropower Plants (SHP), to ensure the sustainability of the river and estuary ecosystems, communities and human welfare. The proposal of a holistic methodology for determining an environmental flow, using either hydrological, hydraulic and habitat methodologies, aims to innovate in the destination, not just of a fixed value of in stream flow, but of a complete system of adequate flows to the river under study. Finally, we present the case of PCH Rio Manso, of property Ecopart Investimentos S.A., located on rio Lourenco Velho, Itajuba city, MG; a project currently under review by the responsible environmental agency, aiming to acquire the Previous License. (author)

  11. DOE Hydropower Program Biennial Report for FY 2005-2006

    Energy Technology Data Exchange (ETDEWEB)

    Sale, Michael J [ORNL; Cada, Glenn F [ORNL; Acker, Thomas L. [Northern Arizona State University and National Renewable Energy Laboratory; Carlson, Thomas [Pacific Northwest National Laboratory (PNNL); Dauble, Dennis D. [Pacific Northwest National Laboratory (PNNL); Hall, Douglas G. [Idaho National Laboratory (INL)

    2006-07-01

    SUMMARY The U.S. Department of Energy (DOE) Hydropower Program is part of the Office of Wind and Hydropower Technologies, Office of Energy Efficiency and Renewable Energy. The Program's mission is to conduct research and development (R&D) that will increase the technical, societal, and environmental benefits of hydropower. The Department's Hydropower Program activities are conducted by its national laboratories: Idaho National Laboratory (INL) [formerly Idaho National Engineering and Environmental Laboratory], Oak Ridge National Laboratory (ORNL), Pacific Northwest National Laboratory (PNNL), and National Renewable Energy Laboratory (NREL), and by a number of industry, university, and federal research facilities. Programmatically, DOE Hydropower Program R&D activities are conducted in two areas: Technology Viability and Technology Application. The Technology Viability area has two components: (1) Advanced Hydropower Technology (Large Turbine Field Testing, Water Use Optimization, and Improved Mitigation Practices) and (2) Supporting Research and Testing (Environmental Performance Testing Methods, Computational and Physical Modeling, Instrumentation and Controls, and Environmental Analysis). The Technology Application area also has two components: (1) Systems Integration and Technology Acceptance (Hydro/Wind Integration, National Hydropower Collaborative, and Integration and Communications) and (2) Supporting Engineering and Analysis (Valuation Methods and Assessments and Characterization of Innovative Technology). This report describes the progress of the R&D conducted in FY 2005-2006 under all four program areas. Major accomplishments include the following: Conducted field testing of a Retrofit Aeration System to increase the dissolved oxygen content of water discharged from the turbines of the Osage Project in Missouri. Contributed to the installation and field testing of an advanced, minimum gap runner turbine at the Wanapum Dam project in Washington

  12. SHP-1 activation inhibits vascular smooth muscle cell proliferation and intimal hyperplasia in a rodent model of insulin resistance and diabetes

    DEFF Research Database (Denmark)

    Qi, Weier; Li, Qian; Liew, Chong Wee

    2017-01-01

    . However, the role of SHP-1 in intimal hyperplasia and restenosis has not been clarified in insulin resistance and diabetes. METHODS: We used a femoral artery wire injury mouse model, rodent models with insulin resistance and diabetes, and patients with type 2 diabetes. Further, we modulated SHP-1...... expression using a transgenic mouse that overexpresses SHP-1 in VSMCs (Shp-1-Tg). SHP-1 agonists were also employed to study the molecular mechanisms underlying the regulation of SHP-1 by oxidised lipids. RESULTS: Mice fed a high-fat diet (HFD) exhibited increased femoral artery intimal hyperplasia...... and decreased arterial SHP-1 expression compared with mice fed a regular diet. Arterial SHP-1 expression was also decreased in Zucker fatty rats, Zucker diabetic fatty rats and in patients with type 2 diabetes. In primary cultured VSMCs, oxidised LDL suppressed SHP-1 expression by activating Mek-1 (also known...

  13. Evaluation of economic rent of hydropower projects

    International Nuclear Information System (INIS)

    Shrestha, Ram M.; Abeygunawardana, A.M.A.K.

    2009-01-01

    Existing studies have mostly estimated the ex post economic rent of hydropower for the hydroelectric system of a province or a country as a whole and have ignored the site- or project-specific variations in the economic rent of hydropower plants. Further, most of the existing studies have used simplified methods to calculate the rent ex post. This paper presents a rigorous methodology for estimation of site-specific (i.e., project specific) economic rent of hydropower ex ante. It applies the methodology in the case of a hydropower project and analyzes the sensitivity of the rent to variations in some key parameters.

  14. Assessing Climate Change Impacts on Global Hydropower

    Directory of Open Access Journals (Sweden)

    Aanund Killingtveit

    2012-02-01

    Full Text Available Currently, hydropower accounts for close to 16% of the world’s total power supply and is the world’s most dominant (86% source of renewable electrical energy. The key resource for hydropower generation is runoff, which is dependent on precipitation. The future global climate is uncertain and thus poses some risk for the hydropower generation sector. The crucial question and challenge then is what will be the impact of climate change on global hydropower generation and what are the resulting regional variations in hydropower generation potential? This paper is a study that aims to evaluate the changes in global hydropower generation resulting from predicted changes in climate. The study uses an ensemble of simulations of regional patterns of changes in runoff, computed from global circulation models (GCM simulations with 12 different models. Based on these runoff changes, hydropower generation is estimated by relating the runoff changes to hydropower generation potential through geographical information system (GIS, based on 2005 hydropower generation. Hydropower data obtained from EIA (energy generation, national sites, FAO (water resources and UNEP were used in the analysis. The countries/states were used as computational units to reduce the complexities of the analysis. The results indicate that there are large variations of changes (increases/decreases in hydropower generation across regions and even within regions. Globally, hydropower generation is predicted to change very little by the year 2050 for the hydropower system in operation today. This change amounts to an increase of less than 1% of the current (2005 generation level although it is necessary to carry out basin level detailed assessment for local impacts which may differ from the country based values. There are many regions where runoff and hydropower generation will increase due to increasing precipitation, but also many regions where there will be a decrease. Based on this

  15. Hydropower externalities: A meta-analysis

    International Nuclear Information System (INIS)

    Mattmann, Matteo; Logar, Ivana; Brouwer, Roy

    2016-01-01

    This paper presents a meta-analysis of existing research related to the economic valuation of the external effects of hydropower. A database consisting of 81 observations derived from 29 studies valuing the non-market impacts of hydropower electricity generation is constructed with the main aim to quantify and explain the economic values for positive and negative hydropower externalities. Different meta-regression model specifications are used to test the robustness of significant determinants of non-market values, including different types of hydropower impacts. The explanatory and predictive power of the estimated models is relatively high. Whilst controlling for sample and study characteristics, we find significant evidence for public aversion towards deteriorations of landscape, vegetation and wildlife caused by hydropower projects. There is however only weak evidence of willingness to pay for mitigating these effects. The main positive externality of hydropower generation, the avoidance of greenhouse gas emission, positively influences welfare estimates when combined with the share of hydropower in national energy production. Sensitivity to scope is detected, but not linked to specific externalities or non-market valuation methods. - Highlights: • A global meta-analysis of valuation studies of hydropower externalities is presented. • Positive and negative externalities are distinguished. • Welfare losses due to environmental deteriorations outweigh gains of GHG reductions. • There is only weak evidence of public WTP for mitigating negative externalities. • The non-market values of hydropower externalities are sensitive to scope.

  16. Small heterodimer partner overexpression partially protects against liver tumor development in farnesoid X receptor knockout mice

    International Nuclear Information System (INIS)

    Li, Guodong; Kong, Bo; Zhu, Yan; Zhan, Le; Williams, Jessica A.; Tawfik, Ossama; Kassel, Karen M.; Luyendyk, James P.; Wang, Li; Guo, Grace L.

    2013-01-01

    Farnesoid X receptor (FXR, Nr1h4) and small heterodimer partner (SHP, Nr0b2) are nuclear receptors that are critical to liver homeostasis. Induction of SHP serves as a major mechanism of FXR in suppressing gene expression. Both FXR −/− and SHP −/− mice develop spontaneous hepatocellular carcinoma (HCC). SHP is one of the most strongly induced genes by FXR in the liver and is a tumor suppressor, therefore, we hypothesized that deficiency of SHP contributes to HCC development in the livers of FXR −/− mice and therefore, increased SHP expression in FXR −/− mice reduces liver tumorigenesis. To test this hypothesis, we generated FXR −/− mice with overexpression of SHP in hepatocytes (FXR −/− /SHP Tg ) and determined the contribution of SHP in HCC development in FXR −/− mice. Hepatocyte-specific SHP overexpression did not affect liver tumor incidence or size in FXR −/− mice. However, SHP overexpression led to a lower grade of dysplasia, reduced indicator cell proliferation and increased apoptosis. All tumor-bearing mice had increased serum bile acid levels and IL-6 levels, which was associated with activation of hepatic STAT3. In conclusion, SHP partially protects FXR −/− mice from HCC formation by reducing tumor malignancy. However, disrupted bile acid homeostasis by FXR deficiency leads to inflammation and injury, which ultimately results in uncontrolled cell proliferation and tumorigenesis in the liver. - Highlights: • SHP does not prevent HCC incidence nor size in FXR KO mice but reduces malignancy. • Increased SHP promotes apoptosis. • Bile acids and inflammation maybe critical for HCC formation with FXR deficiency

  17. PTP1B and SHP2 in POMC neurons reciprocally regulate energy balance in mice

    Science.gov (United States)

    Banno, Ryoichi; Zimmer, Derek; De Jonghe, Bart C.; Atienza, Marybless; Rak, Kimberly; Yang, Wentian; Bence, Kendra K.

    2010-01-01

    Protein tyrosine phosphatase 1B (PTP1B) and SH2 domain–containing protein tyrosine phosphatase–2 (SHP2) have been shown in mice to regulate metabolism via the central nervous system, but the specific neurons mediating these effects are unknown. Here, we have shown that proopiomelanocortin (POMC) neuron–specific deficiency in PTP1B or SHP2 in mice results in reciprocal effects on weight gain, adiposity, and energy balance induced by high-fat diet. Mice with POMC neuron–specific deletion of the gene encoding PTP1B (referred to herein as POMC-Ptp1b–/– mice) had reduced adiposity, improved leptin sensitivity, and increased energy expenditure compared with wild-type mice, whereas mice with POMC neuron–specific deletion of the gene encoding SHP2 (referred to herein as POMC-Shp2–/– mice) had elevated adiposity, decreased leptin sensitivity, and reduced energy expenditure. POMC-Ptp1b–/– mice showed substantially improved glucose homeostasis on a high-fat diet, and hyperinsulinemic-euglycemic clamp studies revealed that insulin sensitivity in these mice was improved on a standard chow diet in the absence of any weight difference. In contrast, POMC-Shp2–/– mice displayed impaired glucose tolerance only secondary to their increased weight gain. Interestingly, hypothalamic Pomc mRNA and α–melanocyte-stimulating hormone (αMSH) peptide levels were markedly reduced in POMC-Shp2–/– mice. These studies implicate PTP1B and SHP2 as important components of POMC neuron regulation of energy balance and point to what we believe to be a novel role for SHP2 in the normal function of the melanocortin system. PMID:20160350

  18. Hydropower in the Southeast: Balancing Lakeview and Production Optimization

    Science.gov (United States)

    Engstrom, J.

    2017-12-01

    Hydropower is the most important source of renewable electricity in Southeastern U.S. However, the region is repeatedly struck by droughts, and there are many conflicting interests in the limited water resource. This study takes a historical perspective and investigates how hydropower production patterns have changed over time, considering both natural drivers and human dimensions. Hydropower production is strongly tied to the natural variability of large-scale atmospheric drivers (teleconnections) as they affect the water availability in the whole river system and partly also the market demand. To balance the water resource between different interests is a complex task, and the conflicting interests vary by basin, sometimes over a relatively small geographic area. Here road networks adjacent to the hydropower reservoirs are used as an indicator of human development and recreational activities. Through a network analysis of the historical development of road networks surrounding the reservoir, the local and regional conflicting interests are identified and the influence on renewable electricity production quantified.

  19. The role of hydropower in meeting Turkey's electric energy demand

    International Nuclear Information System (INIS)

    Yuksek, Omer; Komurcu, Murat Ihsan; Yuksel, Ibrahim; Kaygusuz, Kamil

    2006-01-01

    The inherent technical, economic and environmental benefits of hydroelectric power, make it an important contributor to the future world energy mix, particularly in the developing countries. These countries, such as Turkey, have a great and ever-intensifying need for power and water supplies and they also have the greatest remaining hydro potential. From the viewpoint of energy sources such as petroleum and natural gas, Turkey is not a rich country; but it has an abundant hydropower potential to be used for generation of electricity and must increase hydropower production in the near future. This paper deals with policies to meet the increasing electricity demand for Turkey. Hydropower and especially small hydropower are emphasized as Turkey's renewable energy sources. The results of two case studies, whose results were not taken into consideration in calculating Turkey's hydro electric potential, are presented. Turkey's small hydro power potential is found to be an important energy source, especially in the Eastern Black Sea Region. The results of a study in which Turkey's long-term demand has been predicted are also presented. According to the results of this paper, Turkey's hydro electric potential can meet 33-46% of its electric energy demand in 2020 and this potential may easily and economically be developed

  20. A GIS based assessment of hydropower potential in Hornád basin

    Directory of Open Access Journals (Sweden)

    �ofia Kuzevičová

    2013-12-01

    Full Text Available The issue of efficient use of hydropower, ones of the available renewable resources is currently in the process of sustainable development of each country, often addressing the issue. Incite multiple aspects. It is now seen just growing interest in exploiting the potential of hydropower. On the basis of active efforts are developed to map the total quantity of usability hydropower at basin level in Slovakia. GIS as a powerful and sophisticated tool for processing spatially localized information and offers support for renewable energy sources (not excluding the field of hydropower. Through the integration of spatial data allows assessing the real problems and thus contributing effectively to make rational decisions. Especially in the field of hydropower projects have GIS well founded importance. Of course is important to mention that the potential for hydroelectric power is useless without the operation of hydropower that converts water into electrical energy. For the needs of administrators of watercourses and operators of water systems, the proposed model can be an important tool for decision-making in relation to its implementation activities. Contribution to the design solutions for potential hydropower will address river basin Hornád.

  1. The impact of global change on the hydropower potential of Europe: a model-based analysis

    International Nuclear Information System (INIS)

    Lehner, Bernhard; Czisch, Gregor; Vassolo, Sara

    2005-01-01

    This study presents a model-based approach for analyzing the possible effects of global change on Europe's hydropower potential at a country scale. By comparing current conditions of climate and water use with future scenarios, an overview is provided of today's potential for hydroelectricity generation and its mid- and long-term prospects. The application of the global water model WaterGAP for discharge calculations allows for an integrated assessment, taking both climate and socioeconomic changes into account. This study comprises two key parts: First, the 'gross' hydropower potential is analyzed, in order to outline the general distribution and trends in hydropower capabilities across Europe. Then, the assessment focuses on the 'developed' hydropower potential of existing hydropower plants, in order to allow for a more realistic picture of present and future electricity production. For the second part, a new data set has been developed which geo-references 5991 European hydropower stations and distinguishes them into run-of-river and reservoir stations. The results of this study present strong indications that, following moderate climate and global change scenario assumptions, severe future alterations in discharge regimes have to be expected, leading to unstable regional trends in hydropower potentials with reductions of 25% and more for southern and southeastern European countries

  2. Fibroblast growth factor signaling potentiates VE-cadherin stability at adherens junctions by regulating SHP2.

    Directory of Open Access Journals (Sweden)

    Kunihiko Hatanaka

    Full Text Available The fibroblast growth factor (FGF system plays a critical role in the maintenance of vascular integrity via enhancing the stability of VE-cadherin at adherens junctions. However, the precise molecular mechanism is not well understood. In the present study, we aimed to investigate the detailed mechanism of FGF regulation of VE-cadherin function that leads to endothelial junction stabilization.In vitro studies demonstrated that the loss of FGF signaling disrupts the VE-cadherin-catenin complex at adherens junctions by increasing tyrosine phosphorylation levels of VE-cadherin. Among protein tyrosine phosphatases (PTPs known to be involved in the maintenance of the VE-cadherin complex, suppression of FGF signaling reduces SHP2 expression levels and SHP2/VE-cadherin interaction due to accelerated SHP2 protein degradation. Increased endothelial permeability caused by FGF signaling inhibition was rescued by SHP2 overexpression, indicating the critical role of SHP2 in the maintenance of endothelial junction integrity.These results identify FGF-dependent maintenance of SHP2 as an important new mechanism controlling the extent of VE-cadherin tyrosine phosphorylation, thereby regulating its presence in adherens junctions and endothelial permeability.

  3. Hydropower recovery in water supply systems: Models and case study

    International Nuclear Information System (INIS)

    Vilanova, Mateus Ricardo Nogueira; Balestieri, José Antônio Perrella

    2014-01-01

    Highlights: • We present hydropower recovery models for water supply systems. • Hydropower recovery potential in water supply systems is highly variable. • The case studied could make the supply systems self-sufficient in terms of energy. • Hydropower recovery can reduce GHGs emissions and generate carbon credits. - Abstract: The energy efficiency of water supply systems can be increased through the recovery of hydraulic energy implicit to the volumes of water transported in various stages of the supply process, which can be converted into electricity through hydroelectric recovery systems. Such a process allows the use of a clean energy source that is usually neglected in water supplies, reducing its dependence on energy from the local network and the system’s operation costs. This article evaluates the possibilities and benefits of the use of water supply facilities, structures and equipment for hydraulic energy recovery, addressing several applicable hydroelectric models. A real case study was developed in Brazil to illustrate the technical, economic and environmental aspects of hydropower recovery in water supply systems

  4. Quadrennial Technology Review 2015: Technology Assessments--Hydropower

    Energy Technology Data Exchange (ETDEWEB)

    Sam Baldwin, Gilbert Bindewald, Austin Brown, Charles Chen, Kerry Cheung, Corrie Clark, Joe Cresko,

    2015-10-07

    Hydropower has provided reliable and flexible base and peaking power generation in the United States for more than a century, contributing on average 10.5% of cumulative U.S. power sector net generation over the past six and one-half decades (1949–2013). It is the nation’s largest source of renewable electricity, with 79 GW of generating assets and 22 GW of pumped-storage assets in service, with hydropower providing half of all U.S. renewable power-sector generation (50% in 2014). In addition to this capacity, the U.S. Department of Energy (DOE) has identified greater than 80 GW of new hydropower resource potential: at least 5 GW from rehabilitation and expansion of existing generating assets, up to 12 GW of potential at existing dams without power facilities, and over 60 GW of potential low-impact new development (LIND) in undeveloped stream reaches. However, despite this growth potential, hydropower capacity and production growth have stalled in recent years, with existing assets even experiencing decreases in capacity and production from lack of sustaining investments in infrastructure and increasing constraints on water use.

  5. DOE Hydropower Program biennial report 1992--1993 (with an updated annotated bibliography)

    Energy Technology Data Exchange (ETDEWEB)

    Cada, G.F.; Sale, M.J. [Oak Ridge National Lab., TN (United States); Francfort, J.E.; Rinehart, B.N.; Sommers, G.L. [EG and G Idaho, Inc., Idaho Falls, ID (United States)

    1993-07-01

    This report, the latest in a series of annual/biennial Hydropower Program reports sponsored by the US Department of Energy, summarizes the research and development and technology transfer activities of fiscal years 1992 and 1993. The report discusses the activities in the four areas of the hydropower program: Environmental research; resource assessment; research coat shared with industry; and technology transfer. The report also offers an annotated bibliography of reports pertinent to hydropower, written by persons in Federal and state agencies, cities, metropolitan water districts, irrigation companies, and public and independent utilities. Most reports are available from the National Technical Information Service.

  6. DOE Hydropower Program biennial report 1994--1995 with an updated annotated bibliography

    Energy Technology Data Exchange (ETDEWEB)

    Rinehart, B.N.; Francfort, J.E.; Sommers, G.L. [Lockheed Idaho Technologies Co., Idaho Falls, ID (United States); Cada, G.F.; Sale, M.J. [Oak Ridge National Lab., TN (United States)

    1995-05-01

    This report, the latest in a series of annual/biennial Hydropower Program reports sponsored by the US Department of Energy, summarizes the research and development and technology transfer activities of fiscal years 1994 and 1995. The report discusses the activities in the four areas of the hydropower program: Environmental Research; Resource Assessment; Research Cost-Shared with Industry; and Technology Transfer. The report also includes an annotated bibliography of reports pertinent to hydropower, written by the staff of the Idaho National Engineering Laboratory, Oak Ridge National Laboratory, Federal and state agencies, cities, metropolitan water districts, irrigation companies, and public and independent utilities. Most reports are available from the National Technical Information Service.

  7. DOE Hydropower Program biennial report 1994--1995 with an updated annotated bibliography

    International Nuclear Information System (INIS)

    Rinehart, B.N.; Francfort, J.E.; Sommers, G.L.; Cada, G.F.; Sale, M.J.

    1995-05-01

    This report, the latest in a series of annual/biennial Hydropower Program reports sponsored by the US Department of Energy, summarizes the research and development and technology transfer activities of fiscal years 1994 and 1995. The report discusses the activities in the four areas of the hydropower program: Environmental Research; Resource Assessment; Research Cost-Shared with Industry; and Technology Transfer. The report also includes an annotated bibliography of reports pertinent to hydropower, written by the staff of the Idaho National Engineering Laboratory, Oak Ridge National Laboratory, Federal and state agencies, cities, metropolitan water districts, irrigation companies, and public and independent utilities. Most reports are available from the National Technical Information Service

  8. Role of Shp2 in forebrain neurons in regulating metabolic and cardiovascular functions and responses to leptin.

    Science.gov (United States)

    do Carmo, J M; da Silva, A A; Sessums, P O; Ebaady, S H; Pace, B R; Rushing, J S; Davis, M T; Hall, J E

    2014-06-01

    We examined whether deficiency of Src homology 2 containing phosphatase (Shp2) signaling in forebrain neurons alters metabolic and cardiovascular regulation under various conditions and if it attenuates the anorexic and cardiovascular effects of leptin. We also tested whether forebrain Shp2 deficiency alters blood pressure (BP) and heart rate (HR) responses to acute stress. Forebrain Shp2(-/-) mice were generated by crossing Shp2(flox/flox) mice with CamKIIα-cre mice. At 22-24 weeks of age, the mice were instrumented for telemetry for measurement of BP, HR and body temperature (BT). Oxygen consumption (VO2), energy expenditure and motor activity were monitored by indirect calorimetry. Shp2/CamKIIα-cre mice were heavier (46±3 vs 32±1 g), hyperglycemic, hyperleptinemic, hyperinsulinemic and hyperphagic compared to Shp2(flox/flox) control mice. Shp2/CamKIIα-cre mice exhibited reduced food intake responses to fasting/refeeding and impaired regulation of BT when exposed to 15 and 30 °C ambient temperatures. Despite being obese and having many features of metabolic syndrome, Shp2/CamKIIα-cre mice had similar daily average BP and HR compared to Shp2(flox/flox) mice (112±2 vs 113±1 mm Hg and 595±34 vs 650±40 b.p.m.), but exhibited increased BP and HR responses to cold exposure and acute air-jet stress test. Leptin's ability to reduce food intake and to raise BP were markedly attenuated in Shp2/CamKIIα-cre mice. These results suggest that forebrain Shp2 signaling regulates food intake, appetite responses to caloric deprivation and thermogenic control of body temperature during variations in ambient temperature. Deficiency of Shp2 signaling in the forebrain is associated with augmented cardiovascular responses to cold and acute stress but attenuated BP responses to leptin.

  9. Estimated cumulative sediment trapping in future hydropower reservoirs in Africa

    Science.gov (United States)

    Lucía, Ana; Berlekamp, Jürgen; Zarfl, Christiane

    2017-04-01

    Despite a rapid economic development in Sub-Saharan Africa, almost 70% of the human population in this area remain disconnected from electricity access (International Energy Agency 2011). Mitigating climate change and a search for renewable, "climate neutral" electricity resources are additional reasons why Africa will be one key centre for future hydropower dam building, with only 8% of the technically feasible hydropower potential actually exploited. About 300 major hydropower dams with a total capacity of 140 GW are currently under construction (11.4%) or planned (88.6%) (Zarfl et al. 2015). Despite the benefits of hydropower dams, fragmentation of the rivers changes the natural flow, temperature and sediment regime. This has consequences for a high number of people that directly depend on the primary sector linked to rivers and floodplains. But sediment trapping in the reservoir also affects dam operation and decreases its life span. Thus, the objective of this work is to quantify the dimension of sediment trapping by future hydropower dams in African river basins. Soil erosion is described with the universal soil loss equation (Wischmeier & Smith 1978) and combined with the connectivity index (Cavalli et al. 2013) to estimate the amount of eroded soil that reaches the fluvial network and finally ends up in the existing (Lehner et al. 2011) and future reservoirs (Zarfl et al. 2015) per year. Different scenarios assuming parameter values from the literature are developed to include model uncertainty. Estimations for existing dams will be compared with literature data to evaluate the applied estimation method and scenario assumptions. Based on estimations for the reservoir volume of the future dams we calculated the potential time-laps of the future reservoirs due to soil erosion and depending on their planned location. This approach could support sustainable decision making for the location of future hydropower dams. References Cavalli, M., Trevisani, S., Comiti

  10. Private hydropower projects: exporting the american experience

    International Nuclear Information System (INIS)

    Rogers, W.L.; Bourgeacq, J.P.

    1991-01-01

    This paper addresses different aspects of exporting the American knowledge and experience in the private development of small-scale hydropower projects. It details the 'export' and 'adaptation/translation' of American PURPA philosophy to other countries. The major stumbling blocks on the road to exportation are listed. The subject countries'market evaluation is explained, as well as methods for researching and gathering the necessary information on a specific country. Methods of choosing a target country are discussed, and the criteria necessary for making a choice are detailed. The subject of legal framework and privatization of power generation issues overseas and the ways and means to help the 'export of U.S. expertise' through U.S. Government programs are described. The subjects of financing and joint ventures with local entities are also included in this paper. Various scenarios for private development overseas are presented

  11. Modular Hydropower Engineering and Pilot Scale Manufacturing

    Energy Technology Data Exchange (ETDEWEB)

    Chesser, Phillip C. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2017-09-01

    Emrgy has developed, prototyped and tested a modular hydropower system for renewable energy generation. ORNL worked with Emrgy to demonstrate the use of additive manufacturing in the production of the hydrofoils and spokes for the hydrokinetic system. Specifically, during Phase 1 of this effort, ORNL printed and finished machined patterns for both the hydrofoils and spokes that were subsequently used in a sand casting manufacturing process. Emrgy utilized the sand castings for a pilot installation in Denver, CO, where the parts represented an 80% cost savings from the previous prototype build that was manufactured using subtractive manufacturing. In addition, the castings were completed with ORNL’s newly developed AlCeMg alloy that will be tested for performance improvements including higher corrosion resistance in a water application than the 6160 alloy used previously

  12. The water footprint of electricity from hydropower

    NARCIS (Netherlands)

    Mekonnen, Mesfin; Hoekstra, Arjen Ysbert

    Hydropower accounts for about 16% of the world’s electricity supply. Although dams often have big environmental and social impacts, proponents of hydropower regard it as a comparatively clean, low-cost and renewable form of energy. It has been debated whether hydroelectric generation is merely an

  13. Resource and utilization of Estonian hydropower

    International Nuclear Information System (INIS)

    Raesaar, P.

    2005-01-01

    An overview of the Estonian hydropower resources and their utilization at present as well as prospective for the future are presented in this paper. A short overview of advantages of small hydropower stations and related issues is given. Some technological aspects are treated briefly. (authors)

  14. Big concerns with small projects: Evaluating the socio-ecological impacts of small hydropower projects in India.

    Science.gov (United States)

    Jumani, Suman; Rao, Shishir; Machado, Siddarth; Prakash, Anup

    2017-05-01

    Although Small Hydropower Projects (SHPs) are encouraged as sources of clean and green energy, there is a paucity of research examining their socio-ecological impacts. We assessed the perceived socio-ecological impacts of 4 SHPs within the Western Ghats in India by conducting semi-structured interviews with local respondents. Primary interview data were sequentially validated with secondary data, and respondent perceptions were subsequently compared against the expected baseline of assured impacts. We evaluated the level of awareness about SHPs, their perceived socio-economic impacts, influence on resource access and impacts on human-elephant interactions. The general level of awareness about SHPs was low, and assurances of local electricity and employment generation remained largely unfulfilled. Additionally most respondents faced numerous unanticipated adverse impacts. We found a strong relationship between SHP construction and increasing levels of human-elephant conflict. Based on the disparity between assured and actual social impacts, we suggest that policies regarding SHPs be suitably revised.

  15. External effects in Swiss hydropower

    International Nuclear Information System (INIS)

    Hauenstein, W.; Bonvin, J.; Vouillamoz, J.

    1999-01-01

    The article discusses the external costs and benefits of hydropower that are not internalised in normal book-keeping. Several negative and positive effects are discussed. The results of a study that addressed the difficult task of quantifying these external effects are presented. An assessment of the results gained shows that difficulties are to be met regarding system limits, methods of expressing the effects in monetary terms and ethical factors. The report also examines the consideration of external effects as a correction factor for falsified market prices for electricity

  16. The importance of hydropower in Austria

    International Nuclear Information System (INIS)

    Kobau, R.; Pirker, O.; Spolwind, R.; Weiss, B.

    2009-01-01

    This article discusses the importance of hydropower-based power generation in Austria as a clean and emission-free source of electricity. The contribution made to total electricity generation is examined and figures are quoted. Hydropower is provided from both storage dams and run-of-river power stations such as those on the river Danube. The use of the various types of hydropower in connection with their economic optimisation, for example for the supply of valuable peak power, is discussed. The promotion of hydropower within the scope of European climate-protection efforts is examined. Projects concerning the augmentation of hydropower capacities are discussed and three exemplary projects are briefly described. Finally, the situation in Austria is compared with that to be found in neighbouring Switzerland.

  17. SHP2 regulates chondrocyte terminal differentiation, growth plate architecture and skeletal cell fates.

    Directory of Open Access Journals (Sweden)

    Margot E Bowen

    Full Text Available Loss of PTPN11/SHP2 in mice or in human metachondromatosis (MC patients causes benign cartilage tumors on the bone surface (exostoses and within bones (enchondromas. To elucidate the mechanisms underlying cartilage tumor formation, we investigated the role of SHP2 in the specification, maturation and organization of chondrocytes. Firstly, we studied chondrocyte maturation by performing RNA-seq on primary chondrocyte pellet cultures. We found that SHP2 depletion, or inhibition of the ERK1/2 pathway, delays the terminal differentiation of chondrocytes from the early-hypertrophic to the late-hypertrophic stage. Secondly, we studied chondrocyte maturation and organization in mice with a mosaic postnatal inactivation of Ptpn11 in chondrocytes. We found that the vertebral growth plates of these mice have expanded domains of early-hypertrophic chondrocytes that have not yet terminally differentiated, and their enchondroma-like lesions arise from chondrocytes displaced from the growth plate due to a disruption in the organization of maturation and ossification zones. Furthermore, we observed that lesions from human MC patients also display disorganized chondrocyte maturation zones. Next, we found that inactivation of Ptpn11 in Fsp1-Cre-expressing fibroblasts induces exostosis-like outgrowths, suggesting that loss of SHP2 in cells on the bone surface and at bone-ligament attachment sites induces ectopic chondrogenesis. Finally, we performed lineage tracing to show that exostoses and enchondromas in mice likely contain mixtures of wild-type and SHP2-deficient chondrocytes. Together, these data indicate that in patients with MC, who are heterozygous for inherited PTPN11 loss-of-function mutations, second-hit mutations in PTPN11 can induce enchondromas by disrupting the organization and delaying the terminal differentiation of growth plate chondrocytes, and can induce exostoses by causing ectopic chondrogenesis of cells on the bone surface. Furthermore, the

  18. Analysis of the cost for the refurbishment of small hydropower plants

    International Nuclear Information System (INIS)

    Ogayar, B.; Vidal, P.G.; Hernandez, J.C.

    2009-01-01

    In view of all the concerns associated with fossil fuels and energy demand it is appropriate to investigate the large number of abandoned small hydropower plants. In order to solve the difficulty implied, by a viability study on the refurbishment of a small hydropower plant, a series of simple equations has been developed based on the economic optimization of the different elements. These equations can also be used for completely new hydropower plants. The result of this study will allow us to obtain quite approximate costs for the refurbishment of old hydropower plants, or the construction of new ones. These data on costs will act as a reference to examine real possibilities of refurbishment through different tools of financial and economic analysis. Although the equations developed have used unitary prices referring to Spain, they will be applicable to other countries just changing those prices for those of the country, required. (author)

  19. Disappearing rivers — The limits of environmental assessment for hydropower in India

    International Nuclear Information System (INIS)

    Erlewein, Alexander

    2013-01-01

    The mountain rivers of the Indian Himalaya possess a vast potential for hydropower generation. After decades of comparatively modest development recent years have seen a major intensification in the construction of new hydropower dams. Although increasingly portrayed as a form of renewable energy generation, hydropower development may lead to extensive alterations of fluvial systems and conflicts with resource use patterns of local communities. To appraise and reduce adverse effects is the purpose of statutory Environmental Impact Assessments (EIA) and corresponding mitigation plans. However, in the light of ambitious policies for hydropower expansion conventional approaches of environmental assessment are increasingly challenged to keep up with the intensity and pace of development. This paper aims to explore the systemic limitations of environmental assessment for hydropower development in the Indian state of Himachal Pradesh. Based on a qualitative methodology involving interviews with environmental experts, document reviews and field observations the study suggests that the current practice of constraining EIAs to the project level fails to address the larger effects of extensive hydropower development. Furthermore, it is critically discussed as to what extent the concept of Strategic Environmental Assessment (SEA) might have the potential to overcome existing shortcomings

  20. 75 FR 16456 - Inglis Hydropower, LLC; Notice Soliciting Scoping Comments

    Science.gov (United States)

    2010-04-01

    ... Hydropower, LLC; Notice Soliciting Scoping Comments March 26, 2010. Take notice that the following...: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The proposed project... Commission staff intends to prepare a single Environmental Assessment (EA) for the Inglis Hydropower Project...

  1. Turbine Aeration Design Software for Mitigating Adverse Environmental Impacts Resulting From Conventional Hydropower Turbines

    Energy Technology Data Exchange (ETDEWEB)

    Gulliver, John S. [Univ. of Minnesota, Minneapolis, MN (United States)

    2015-03-01

    Conventional hydropower turbine aeration test-bed for computational routines and software tools for improving environmental mitigation technologies for conventional hydropower systems. In achieving this goal, we have partnered with Alstom, a global leader in energy technology development and United States power generation, with additional funding from the Initiative for Renewable Energy and the Environment (IREE) and the College of Science and Engineering (CSE) at the UMN

  2. Expression and clinical significance of tyrosine phosphatase SHP-2 in colon cancer.

    Science.gov (United States)

    Cai, Peifen; Guo, Wenjie; Yuan, Huaqin; Li, Qian; Wang, Weicheng; Sun, Yang; Li, Xiaomin; Gu, Yanhong

    2014-04-01

    Protein-tyrosine phosphatase SHP-2, encoded by gene PTPN11, has been identified as a tumor-promoting factor in several types of leukemia and is hyper-activated by other mechanisms in some solid tumors including gastric cancer, breast cancer, non-small cell lung cancer (NSCLC), etc. But few were reported on the expression and significances of SHP-2 in colon cancer. Here, we detect SHP-2 expression in colon cancer cells, colon cancer-induced by AOM+DSS in mice and 232 human colon cancer specimens, including 58 groups of self-matched adjacent peritumor tissues and normal tissues. We found that compared to the normal colon tissues, SHP-2 significantly decreased in tumor tissues (Pcolon tumor cells as well as mice colon tumors. And in humans samples, low SHP-2 expression showed a significantly correlation with poor tumor differentiation (P<0.05), late TNM stage (P=0.1666) and lymph node metastasis (P<0.05). Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  3. Hydropower - internalized costs and externalized benefits

    International Nuclear Information System (INIS)

    Koch, F.H.

    2002-01-01

    The benefits of hydropower consist of the minimal level of noxious and greenhouse gas emissions, it's energy security from political instability, and its renewable, non-depletable nature. The costs of hydropower consist of negative effects on the river ecosystem and of social changes in communities in the vicinity of large projects. Public awareness of these costs has increased dramatically during the past two decades, and new hydro projects will not get approval unless adequate mitigation measures are taken to avoid, offset, or compensate for adverse environmental and social effects. To a very large extent, the hydropower industry has internalized what were previously social and environmental externalities. However, hydropower operators do not receive any compensation for the benefits, and to date their competitors (coal, natural gas, oil) have not been required to internalize their adverse environmental externalities. (emissions, depletion of supplies, and sometimes dependence on imported primary energy sources). This creates an uneven playing field, and the hydropower industry enthusiastically welcomes a discussion of this issue, and eventually measures to rectify the situation. The IEA Hydropower Agreement has completed a major international study on the environmental and social impacts of hydropower, and one major component of this study was a Life Cycle Assessment and comparison of all the most important electricity generation technologies. (author)

  4. 78 FR 14528 - Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and...

    Science.gov (United States)

    2013-03-06

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 11169-029] Mayo Hydropower, LLC, Avalon Hydropower, LLC; Notice of Application for Transfer of License, and Soliciting Comments and Motions To Intervene On November 20, 2012, Mayo Hydropower, LLC (transferor) and Avalon Hydropower...

  5. The role of energy systems on hydropower in Turkey

    Science.gov (United States)

    Yuksel, Ibrahim; Arman, Hasan; Halil Demirel, Ibrahim

    2017-11-01

    Over the last two decades, global electricity production has more than doubled and electricity demand is rising rapidly around the world as economic development spreads to emerging economies. Not only has electricity demand increased significantly, it is the fastest growing end-use of energy. Therefore, technical, economic and environmental benefits of hydroelectric power make it an important contributor to the future world energy mix, particularly in the developing countries. On the other hand, the hydropower industry is closely linked to both water management and renewable energy production, and so has a unique role to play in contributing to sustainable development in a world where billions of people lack access to safe drinking water and adequate energy supplies. In addition to, approximately 1.6 billion people have no access to electricity and about 1.1 billion are without adequate water supply. However, resources for hydropower development are widely spread around the world. Potential exists in about 150 countries, and about 70% of the economically feasible potential remains to be developed-mostly in developing countries where the needs are most urgent. This paper deals with renewable energy systems and the role of hydropower in Turkey.

  6. A Hydropower Biological Evaluation Toolset (HBET) for Characterizing Hydraulic Conditions and Impacts of Hydro-Structures on Fish

    Energy Technology Data Exchange (ETDEWEB)

    Hou, Hongfei; Deng, Zhiqun; Martinez, Jayson; Fu, Tao; Duncan, Joanne; Johnson, Gary; Lu, Jun; Skalski, John; Townsend, Richard; Tan, Li

    2018-04-01

    Currently, approximately 16% of the world’s electricity and over 80% of the world’s renewable electricity is generated from hydropower resources, and there is potential for development of a significant amount of new hydropower capacity. However, in practice, realizing all the potential hydropower resource is limited by various factors, including environmental effects and related mitigation requirements. That is why hydropower regulatory requirements frequently call for targets to be met regarding fish injury and mortality rates. Hydropower Biological Evaluation Toolset (HBET), an integrated suite of software tools, is designed to characterize hydraulic conditions of hydropower structures and provide quantitative estimates of fish injury and mortality rates due to various physical stressors including strike, pressure, and shear. HBET enables users to design new studies, analyze data, perform statistical analyses, and evaluate biological responses. In this paper, we discuss the features of the HBET software and describe a case study that illustrates its functionalities. HBET can be used by turbine manufacturers, hydropower operators, and regulators to design and operate hydropower systems that minimize ecological impacts in a cost-effective manner.

  7. Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1

    International Nuclear Information System (INIS)

    Oiwa, Ako; Kakizawa, Tomoko; Miyamoto, Takahide; Yamashita, Koh; Jiang, Wei; Takeda, Teiji; Suzuki, Satoru; Hashizume, Kiyoshi

    2007-01-01

    Small heterodimer partner (SHP; NR0B2) is an orphan nuclear receptor and acts as a repressor for wide variety of nuclear hormone receptors. We demonstrated here that mouse SHP mRNA showed a circadian expression pattern in the liver. Transient transfection of the mSHP promoter demonstrated that CLOCK-BMAL1, core circadian clock components, bound to E-box (CACGTG), and stimulated the promoter activity by 4-fold. Liver receptor homologue-1 (LRH-1; NR5A2) stimulated the mSHP promoter, and CLOCK-BMAL1 synergistically enhanced the LRH-1-mediated transactivation. Interestingly, SHP did not affect the CLOCK-BMAL1-mediated promoter activity, but strongly repressed the synergistic activation of CLOCK-BMAL1 and LRH-1. Furthermore, in vitro pull-down assays revealed the existence of direct protein-protein interaction between LRH-1 and CLOCK. In summary, this study shows that CLOCK-BMAL1, LRH-1 and SHP coordinately regulate the mSHP gene to generate the circadian oscillation. The cyclic expression of mSHP may affect daily activity of other nuclear receptors and contribute to circadian liver functions

  8. Optimization of cascade hydropower system operation by genetic algorithm to maximize clean energy output

    Directory of Open Access Journals (Sweden)

    Aida Tayebiyan

    2016-06-01

    Full Text Available Background: Several reservoir systems have been constructed for hydropower generation around the world. Hydropower offers an economical source of electricity with reduce carbon emissions. Therefore, it is such a clean and renewable source of energy. Reservoirs that generate hydropower are typically operated with the goal of maximizing energy revenue. Yet, reservoir systems are inefficiently operated and manage according to policies determined at the construction time. It is worth noting that with little enhancement in operation of reservoir system, there could be an increase in efficiency of the scheme for many consumers. Methods: This research develops simulation-optimization models that reflect discrete hedging policy (DHP to manage and operate hydropower reservoir system and analyse it in both single and multireservoir system. Accordingly, three operational models (2 single reservoir systems and 1 multi-reservoir system were constructed and optimized by genetic algorithm (GA. Maximizing the total power generation in horizontal time is chosen as an objective function in order to improve the functional efficiency in hydropower production with consideration to operational and physical limitations. The constructed models, which is a cascade hydropower reservoirs system have been tested and evaluated in the Cameron Highland and Batang Padang in Malaysia. Results: According to the given results, usage of DHP for hydropower reservoir system operation could increase the power generation output to nearly 13% in the studied reservoir system compared to present operating policy (TNB operation. This substantial increase in power production will enhance economic development. Moreover, the given results of single and multi-reservoir systems affirmed that hedging policy could manage the single system much better than operation of the multi-reservoir system. Conclusion: It can be summarized that DHP is an efficient and feasible policy, which could be used

  9. Projected impacts of climate change on hydropower potential in China

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xingcai; Tang, Qiuhong; Voisin, Nathalie; Cui, Huijuan

    2016-01-01

    Hydropower is an important renewable energy source in China, but it is sensitive to climate change, because the changing climate may alter hydrological conditions (e.g., river flow and reservoir storage). Future changes and associated uncertainties in China's gross hydropower potential (GHP) and developed hydropower potential (DHP) are projected using simulations from eight global hydrological models (GHMs), including a large-scale reservoir regulation model, forced by five general circulation models (GCMs) with climate data under two representative concentration pathways (RCP2.6 and RCP8.5). Results show that the estimation of the present GHP of China is comparable to other studies; overall, the annual GHP is projected to change by −1.7 to 2 % in the near future (2020–2050) and increase by 3 to 6 % in the late 21st century (2070–2099). The annual DHP is projected to change by −2.2 to −5.4 % (0.7–1.7 % of the total installed hydropower capacity (IHC)) and −1.3 to −4 % (0.4–1.3 % of total IHC) for 2020–2050 and 2070–2099, respectively. Regional variations emerge: GHP will increase in northern China but decrease in southern China – mostly in south central China and eastern China – where numerous reservoirs and large IHCs currently are located. The area with the highest GHP in southwest China will have more GHP, while DHP will reduce in the regions with high IHC (e.g., Sichuan and Hubei) in the future. The largest decrease in DHP (in %) will occur in autumn or winter, when streamflow is relatively low and water use is competitive. Large ranges in hydropower estimates across GHMs and GCMs highlight the necessity of using multimodel assessments under climate change conditions. This study prompts the consideration of climate change in planning for hydropower development and operations in China, to be further combined with a socioeconomic analysis for strategic expansion.

  10. PREDICTION OF TOTAL DISSOLVED GAS EXCHANGE AT HYDROPOWER DAMS

    Energy Technology Data Exchange (ETDEWEB)

    Hadjerioua, Boualem [ORNL; Pasha, MD Fayzul K [ORNL; Stewart, Kevin M [ORNL; Bender, Merlynn [Bureau of Reclamation; Schneider, Michael L. [U.S. Army Corps of Engineers

    2012-07-01

    Total dissolved gas (TDG) supersaturation in waters released at hydropower dams can cause gas bubble trauma in fisheries resulting in physical injuries and eyeball protrusion that can lead to mortality. Elevated TDG pressures in hydropower releases are generally caused by the entrainment of air in spillway releases and the subsequent exchange of atmospheric gasses into solution during passage through the stilling basin. The network of dams throughout the Columbia River Basin (CRB) are managed for irrigation, hydropower production, flood control, navigation, and fish passage that frequently result in both voluntary and involuntary spillway releases. These dam operations are constrained by state and federal water quality standards for TDG saturation which balance the benefits of spillway operations designed for Endangered Species Act (ESA)-listed fisheries versus the degradation to water quality as defined by TDG saturation. In the 1970s, the United States Environmental Protection Agency (USEPA), under the federal Clean Water Act (Section 303(d)), established a criterion not to exceed the TDG saturation level of 110% in order to protect freshwater and marine aquatic life. The states of Washington and Oregon have adopted special water quality standards for TDG saturation in the tailrace and forebays of hydropower facilities on the Columbia and Snake Rivers where spillway operations support fish passage objectives. The physical processes that affect TDG exchange at hydropower facilities have been studied throughout the CRB in site-specific studies and routine water quality monitoring programs. These data have been used to quantify the relationship between project operations, structural properties, and TDG exchange. These data have also been used to develop predictive models of TDG exchange to support real-time TDG management decisions. These empirically based predictive models have been developed for specific projects and account for both the fate of spillway and

  11. SHP1-mediated cell cycle redistribution inhibits radiosensitivity of non-small cell lung cancer

    International Nuclear Information System (INIS)

    Cao, Rubo; Ding, Qian; Li, Pindong; Xue, Jun; Zou, Zhenwei; Huang, Jing; Peng, Gang

    2013-01-01

    Radioresistance is the common cause for radiotherapy failure in non-small cell lung cancer (NSCLC), and the degree of radiosensitivity of tumor cells is different during different cell cycle phases. The objective of the present study was to investigate the effects of cell cycle redistribution in the establishment of radioresistance in NSCLC, as well as the signaling pathway of SH2 containing Tyrosine Phosphatase (SHP1). A NSCLC subtype cell line, radioresistant A549 (A549S1), was induced by high-dose hypofractionated ionizing radiations. Radiosensitivity-related parameters, cell cycle distribution and expression of cell cycle-related proteins and SHP1 were investigated. siRNA was designed to down-regulate SHP1expression. Compared with native A549 cells, the proportion of cells in the S phase was increased, and cells in the G0/G1 phase were consequently decreased, however, the proportion of cells in the G2/M phase did not change in A549S1 cells. Moreover, the expression of SHP1, CDK4 and CylinD1 were significantly increased, while p16 was significantly down-regulated in A549S1 cells compared with native A549 cells. Furthermore, inhibition of SHP1 by siRNA increased the radiosensitivity of A549S1 cells, induced a G0/G1 phase arrest, down-regulated CDK4 and CylinD1expressions, and up-regulated p16 expression. SHP1 decreases the radiosensitivity of NSCLC cells through affecting cell cycle distribution. This finding could unravel the molecular mechanism involved in NSCLC radioresistance

  12. Long-term scheduling of large cascade hydropower stations in Jinsha River, China

    International Nuclear Information System (INIS)

    Wang, Chao; Zhou, Jianzhong; Lu, Peng; Yuan, Liu

    2015-01-01

    Highlights: • Proposing a Gaussian group selection strategy to overcome premature convergence. • Multi-population ant are developed to enhance the search ability. • Proposing a circulatory solution correction to handle constraints. • Numerical and real hydropower system simulation are used to verify its performance. • Compensation analysis has been done to large hydropower stations in Jinsha River. - Abstract: The Jinsha River is the third longest river in the world. It consists of four large hydropower stations with total installed capacity 42,960 MW lying on the upper stretches of the Yangtze River, which is the longest river in the word. Due to the great potential of large cascade hydropower stations on power generation, long-term scheduling of large cascade hydropower stations (LSLCHS) plays an important role in electrical power system. As more and more concentrations focused on the optimal operation of large cascade hydropower stations, the LSLCHS has been taken into a multi-dimensional, non-convex and non-linear optimization problem due to its complicated hydraulic connection relationships and varieties of complex constraints with considering its power generation, shipping and ecological characteristics. In order to solve this problem, a multi-population ant colony optimization for continuous domain (MACO R ) is proposed in this paper. A Gaussian group selection strategy is applied to overcome premature convergence and ants with different characteristics are employed to enhance search ability, and circulatory solution correction strategy is presented to handle outflow, water level and output constraints. Furthermore, the efficiency and stability of MACO R are verified by its more desirable results in comparison to other latest works in numerical simulation, and it can be a viable alternative for solving those complicated optimal problems. With the applications in hydropower operation, LSLCHS can obtain more power generation benefit than other

  13. Simplified matrix for assessment to environmental impacts on small hydroelectric power plants (SHP); Matriz simplificada para avaliar impactos ambientais em pequenas centrais hidreletricas (PCH)

    Energy Technology Data Exchange (ETDEWEB)

    Barbosa, Tania A.P. de Souza; Dupas, Francisco Antonio [Universidade Federal de Itajuba, MG (Brazil). Inst. de Recursos Naturais]. E-mails: taniabarbosa@unifei.edu.br; dupas@unifei.edu.br

    2006-07-01

    This work intends to study the methodologies used by EIA and proposes the adaptation of a simplified matrix for the assessment of environmental impacts regarding small hydropower plants. A case study of Ninho da Aguia SHP, located in the city of Delfim Moreira, MG, was used for elaborating the matrix. The methodology used the analysis of all the negative impacts and they were given combined weight based on a pre-established impact scale. The weights that were given to each impact were distributed according to the combination of features presented in the referred EIA. The results attained show that the environmental damage is reduced by 45% when the mitigating measures suggested by the EIA and by the analysis carried out by this study are applied. Besides, this preliminary proposal will make it possible for the process of getting an environmental license to be accelerated. Today, this process is considered as an investment inhibitor because of its slowness caused by the environmental organs that analyze these studies. Also, it may be used as initial guidelines regarding the environmental cost of the implementation of the enterprise. The proposed matrix shows itself as efficient because it is easy to be used and it is a useful tool for the analysis of projects that will be implemented.

  14. Harnessing the hydropower potential in Africa: What should be the place and role of Grand Inga hydropower project?

    Energy Technology Data Exchange (ETDEWEB)

    Fall, Latsoucabe

    2010-09-15

    Harnessing Africa's huge hydropower potential should be made a priority for the sustainable development of the Continent. Particularly, Grand Inga hydropower project in DRC, due to its gigantic size (40,000 MW) and favourable natural characteristics, could be 'Africa's flagship Project of the 21st Century' offering enormous comparative advantages and opportunities for the benefits of the entire African Continent. Nevertheless, to make it a feasible and palpable 'Model Project', capable of producing clean and affordable energy, the paper tries to respond to key questions on the several daunting challenges to address for its sustainable, cost-effective and timely development and operation.

  15. Hydropower Manufacturing and Supply Chain Analysis

    Energy Technology Data Exchange (ETDEWEB)

    Cotrell, Jason R [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

    2018-01-02

    Hydropower Manufacturing and Supply Chain Analysis presentation from the WPTO FY14-FY16 Peer Review. The project objective is to provide data and insights to inform investment strategies, policy, and other decisions to promote economic growth and manufacturing.

  16. The future of hydropower in Europe: Interconnecting climate, markets and policies

    International Nuclear Information System (INIS)

    Gaudard, Ludovic; Romerio, Franco

    2014-01-01

    Highlights: • Connecting the knowledges from various domains, in particular economics, engineering, policy and hydrology. • Giving the keys to assess the linking between hydropower, climate and electricity market. • Making an overall analysis. - Abstract: Hydropower is very important for electricity supply security in the European inter-connexion as well as for the economy of regions (primarily peripheral) that possess water resources. Its future may however be jeopardized by several factors: climate change, the development of new renewable energy, the creation of super and micro-grids, and progress in power storage technology. Energy and climate policy, as well as electricity market design and dynamics play a pivotal role. This article carries out a comprehensive analysis of all these factors and discusses the future of hydropower. This discussion follows an overview of the present situation and of future drivers. The technical, environmental, economic and political aspects of the problem are analyzed with an interdisciplinary approach. The stakes as well as the uncertainties are highlighted. The conclusion is that hydropower has a promising future, particularly in light of emerging sustainable energy policy, but that the risks should not be overlooked. Academics will find a comprehensive interdisciplinary analysis of hydropower in this article, whereas public bodies, communities and hydropower companies can identify the strategic variables that should be taken into consideration in the decision making process. The end of water concessions or authorizations is also evoked

  17. Reprint of “The future of hydropower in Europe: Interconnecting climate, markets and policies”

    International Nuclear Information System (INIS)

    Gaudard, Ludovic; Romerio, Franco

    2014-01-01

    Highlights: • Connecting the knowledges from various domains, in particular economics, engineering, policy and hydrology. • Giving the keys to assess the linking between hydropower, climate and electricity market. • Making an overall analysis. - Abstract: Hydropower is very important for electricity supply security in the European inter-connexion as well as for the economy of regions (primarily peripheral) that possess water resources. Its future may however be jeopardized by several factors: climate change, the development of new renewable energy, the creation of super and micro-grids, and progress in power storage technology. Energy and climate policy, as well as electricity market design and dynamics play a pivotal role. This article carries out a comprehensive analysis of all these factors and discusses the future of hydropower. This discussion follows an overview of the present situation and of future drivers. The technical, environmental, economic and political aspects of the problem are analyzed with an interdisciplinary approach. The stakes as well as the uncertainties are highlighted. The conclusion is that hydropower has a promising future, particularly in light of emerging sustainable energy policy, but that the risks should not be overlooked. Academics will find a comprehensive interdisciplinary analysis of hydropower in this article, whereas public bodies, communities and hydropower companies can identify the strategic variables that should be taken into consideration in the decision making process. The end of water concessions or authorizations is also evoked

  18. Modeling Net Land Occupation of Hydropower Reservoirs in Norway for Use in Life Cycle Assessment.

    Science.gov (United States)

    Dorber, Martin; May, Roel; Verones, Francesca

    2018-02-20

    Increasing hydropower electricity production constitutes a unique opportunity to mitigate climate change impacts. However, hydropower electricity production also impacts aquatic and terrestrial biodiversity through freshwater habitat alteration, water quality degradation, and land use and land use change (LULUC). Today, no operational model exists that covers any of these cause-effect pathways within life cycle assessment (LCA). This paper contributes to the assessment of LULUC impacts of hydropower electricity production in Norway in LCA. We quantified the inundated land area associated with 107 hydropower reservoirs with remote sensing data and related it to yearly electricity production. Therewith, we calculated an average net land occupation of 0.027 m 2 ·yr/kWh of Norwegian storage hydropower plants for the life cycle inventory. Further, we calculated an adjusted average land occupation of 0.007 m 2 ·yr/kWh, accounting for an underestimation of water area in the performed maximum likelihood classification. The calculated land occupation values are the basis to support the development of methods for assessing the land occupation impacts of hydropower on biodiversity in LCA at a damage level.

  19. Large-Scale Phosphoproteomics Reveals Shp-2 Phosphatase-Dependent Regulators of Pdgf Receptor Signaling

    DEFF Research Database (Denmark)

    Batth, Tanveer S; Papetti, Moreno; Pfeiffer, Anamarija

    2018-01-01

    Despite its low cellular abundance, phosphotyrosine (pTyr) regulates numerous cell signaling pathways in health and disease. We applied comprehensive phosphoproteomics to unravel differential regulators of receptor tyrosine kinase (RTK)-initiated signaling networks upon activation by Pdgf-ββ, Fgf-2...... of Pdgfr pTyr signaling. Application of a recently introduced allosteric Shp-2 inhibitor revealed global regulation of the Pdgf-dependent tyrosine phosphoproteome, which significantly impaired cell migration. In addition, we present a list of hundreds of Shp-2-dependent targets and putative substrates...

  20. Tyr66 acts as a conformational switch in the closed-to-open transition of the SHP-2 N-SH2-domain phosphotyrosine-peptide binding cleft

    Directory of Open Access Journals (Sweden)

    MacKerell Alexander D

    2007-03-01

    : mutations at Tyr66, Asp40, Lys55, and/or Gln57 are predicted to break the switching mechanism and negatively impact pY-peptide binding. This in turn would interfere with cellular localization and the coupled SHP-2 phosphatase activity. The structurally well-defined binding cleft conformations resulting from the switch-like transition suggest the possibility of applying structure-based methods to develop inhibitors of N-SH2 pY-peptide binding to serve as research tools for signal transduction and precursors to therapeutics for SHP-2-related diseases.

  1. The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α protein levels in endothelial cells under hypoxia.

    Directory of Open Access Journals (Sweden)

    Stefan K Alig

    Full Text Available The tyrosine phosphatase SHP-1 negatively influences endothelial function, such as VEGF signaling and reactive oxygen species (ROS formation, and has been shown to influence angiogenesis during tissue ischemia. In ischemic tissues, hypoxia induced angiogenesis is crucial for restoring oxygen supply. However, the exact mechanism how SHP-1 affects endothelial function during ischemia or hypoxia remains unclear. We performed in vitro endothelial cell culture experiments to characterize the role of SHP-1 during hypoxia.SHP-1 knock-down by specific antisense oligodesoxynucleotides (AS-Odn increased cell growth as well as VEGF synthesis and secretion during 24 hours of hypoxia compared to control AS-Odn. This was prevented by HIF-1α inhibition (echinomycin and apigenin. SHP-1 knock-down as well as overexpression of a catalytically inactive SHP-1 (SHP-1 CS further enhanced HIF-1α protein levels, whereas overexpression of a constitutively active SHP-1 (SHP-1 E74A resulted in decreased HIF-1α levels during hypoxia, compared to wildtype SHP-1. Proteasome inhibition (MG132 returned HIF-1α levels to control or wildtype levels respectively in these cells. SHP-1 silencing did not alter HIF-1α mRNA levels. Finally, under hypoxic conditions SHP-1 knock-down enhanced intracellular endothelial reactive oxygen species (ROS formation, as measured by oxidation of H2-DCF and DHE fluorescence.SHP-1 decreases half-life of HIF-1α under hypoxic conditions resulting in decreased cell growth due to diminished VEGF synthesis and secretion. The regulatory effect of SHP-1 on HIF-1α stability may be mediated by inhibition of endothelial ROS formation stabilizing HIF-1α protein. These findings highlight the importance of SHP-1 in hypoxic signaling and its potential as therapeutic target in ischemic diseases.

  2. Hydropower scene: boost for Dominican power supply

    Energy Technology Data Exchange (ETDEWEB)

    1988-12-01

    When it is completed in 1991, the 150 MW Jiguey-Aguacate multi-purpose hydropower scheme will be the largest hydro project in the Dominican Republic. Construction of the scheme was recommended as a result of various studies carried out by the Instituto Nacional de Recursos Hidraulicos (INDHRI), which examined the hydropower potential of the Niazo river. Work is now in progress on site, with commissioning of the first unit expected in 1990.

  3. Renovation and uprating of seven hydropower plants in Java

    International Nuclear Information System (INIS)

    Nuessli, W.

    1991-01-01

    The Indonesian Power Authority is planning to renovate and uprate seven hydropower stations in Java to expand plant life expectancy, ensure operating safety and reliability, and increase power and generation within economical limits. The power plants were constructed in the early 1920s and extended between 1945 and 1950. Their capacities vary between 4 and 20 MW. For the renovation project, Colenco Power Consulting Ltd. is acting as a consultant to PLN. In February 1990, Colenco inspected all seven power plants. The results of the inspections served as the basis for the development of renovation plans for each of the seven hydropower plants. To determine the cost of the proposed renovation plans, appraisers had to determine a method for comparing the value of an existing plant to that of a renovated one. The two different evaluation methods used for these comparisons are the focus of this paper

  4. Development of a project on North Unit Irrigation District’s Main Canal at the Monroe Drop, using a novel low-head hydropower technology called the SLH100

    Energy Technology Data Exchange (ETDEWEB)

    Schneider, Abraham [Natel Energy, Inc., Alameda, CA (United States); Schneider, Gia [Natel Energy, Inc., Alameda, CA (United States); McKinstry, Katherine [Natel Energy, Inc., Alameda, CA (United States); Harwood, Meghan [Natel Energy, Inc., Alameda, CA (United States)

    2017-03-14

    Natel Energy is a low­-head, distributed hydropower company based out of Alameda, CA. Natel manufactures and sells proprietary hydroelectric turbines called hydroEngines® that are suitable for low-­head, high-­flow settings, and range from 30kW to 1 MW of capacity per unit. Natel’s hydroEngine is a state­-of­the-­art two stage impulse turbine, using blades mounted symmetrically on two belts perpendicular to the axis of travel, and using linearly­-moving foils, rather than a rotor, to enable efficient conversion of kinetic energy of large volumes of water at low head with no risk of cavitation. In addition, the hydroEngine can be installed at or above tailwater level, reducing the excavation necessary to build the powerhouse and thus reducing total installed cost and project footprint. Thus, the hydroEngine technology enables a new generation of small hydro installations with low cost of project development, fish-­friendly operations, and small project footprint. In September of 2015, Natel Energy formally commissioned its first project installation in Madras, Oregon, installing 1 SLH100 turbine at an existing drop structure on the North Unit Irrigation District (NUID) Main Canal. The water falls between 13.5 feet to 16.5 feet at this structure, depending on flow. The plant has an installed capacity of 250 kW and an expected annual generation of approximately 873 MWh. The plant operates at an annual capacity factor of 40%, and a capacity factor over the irrigation season, or period of available flow, of 80%. Annual capacity factor is calculated as a percentage of plant operating hours relative to a total of 8,760 hours in a year; because the irrigation canal in which the Project is located only runs water from April to October, the available flow capacity factor is higher. Net greenhouse gas reductions from the Monroe Project are estimated to be 602 tCO2/year. The purpose of this report is to provide an overview of the specifications for Natel’s first

  5. Hydropower Resource Assessment of Brazilian Streams

    Energy Technology Data Exchange (ETDEWEB)

    Douglas G. Hall

    2011-09-01

    The Idaho National Laboratory (INL) in collaboration with the U.S. Geological Survey (USGS) with the assistance of the Empresa de Pesquisa Energetica (EPE) and the Agencia Nacional de Energia Electrica (ANEEL) has performed a comprehensive assessment of the hydropower potential of all Brazilian natural streams. The methodology by which the assessment was performed is described. The results of the assessment are presented including an estimate of the hydropower potential for all of Brazil, and the spatial distribution of hydropower potential thus providing results on a state by state basis. The assessment results have been incorporated into a geographic information system (GIS) application for the Internet called the Virtual Hydropower Prospector do Brasil. VHP do Brasil displays potential hydropower sites on a map of Brazil in the context of topography and hydrography, existing power and transportation infrastructure, populated places and political boundaries, and land use. The features of the application, which includes tools for finding and selecting potential hydropower sites and other features and displaying their attributes, is fully described.

  6. Fuzzy multiobjective models for optimal operation of a hydropower system

    Science.gov (United States)

    Teegavarapu, Ramesh S. V.; Ferreira, André R.; Simonovic, Slobodan P.

    2013-06-01

    Optimal operation models for a hydropower system using new fuzzy multiobjective mathematical programming models are developed and evaluated in this study. The models use (i) mixed integer nonlinear programming (MINLP) with binary variables and (ii) integrate a new turbine unit commitment formulation along with water quality constraints used for evaluation of reservoir downstream impairment. Reardon method used in solution of genetic algorithm optimization problems forms the basis for development of a new fuzzy multiobjective hydropower system optimization model with creation of Reardon type fuzzy membership functions. The models are applied to a real-life hydropower reservoir system in Brazil. Genetic Algorithms (GAs) are used to (i) solve the optimization formulations to avoid computational intractability and combinatorial problems associated with binary variables in unit commitment, (ii) efficiently address Reardon method formulations, and (iii) deal with local optimal solutions obtained from the use of traditional gradient-based solvers. Decision maker's preferences are incorporated within fuzzy mathematical programming formulations to obtain compromise operating rules for a multiobjective reservoir operation problem dominated by conflicting goals of energy production, water quality and conservation releases. Results provide insight into compromise operation rules obtained using the new Reardon fuzzy multiobjective optimization framework and confirm its applicability to a variety of multiobjective water resources problems.

  7. Small hydropower plants in the region of Mariovo (Macedonia)

    International Nuclear Information System (INIS)

    Panovski, Sotir; Anastasov, Ljupcho

    2003-01-01

    In this paper the results of an initial Pre-feasibility study within the framework of the PHARE Programme for Cross Border Cooperation between Republic of Macedonia and Republic of Greece. In this study we have looked at the existing research originating from three sources. The Strategies for Economic Development of Republic of Macedonia, the Development Plans of the Electric Power Company of Macedonia as well as the existing technical documentation and studies on a level of idea projects for specific location for small hydropower plants in Mariovo region. Furthermore, analysis and evaluation of this documentation is included. Research done in this region has produced evidence of numerous potential locations for small hydropower plants (total of 46) generating power between 58 kW and 4900 kW, discharging between 0,082 m 3 /s and 30 m 3 /s with a head between 6 m and 208 m for which we have detailed data. Furthermore, in the paper we pay attention to the enormous and so far unrealised hydro energetic power which could be utilised by constructing small hydropower plants in Republic of Macedonia. specifically in the Mariovo region. (Original)

  8. Shp2 signaling in POMC neurons is important for leptin's actions on blood pressure, energy balance, and glucose regulation.

    Science.gov (United States)

    do Carmo, Jussara M; da Silva, Alexandre A; Ebaady, Sabira E; Sessums, Price O; Abraham, Ralph S; Elmquist, Joel K; Lowell, Bradford B; Hall, John E

    2014-12-15

    Previous studies showed that Src homology-2 tyrosine phosphatase (Shp2) is an important regulator of body weight. In this study, we examined the impact of Shp2 deficiency specifically in proopiomelanocortin (POMC) neurons on metabolic and cardiovascular function and on chronic blood pressure (BP) and metabolic responses to leptin. Mice with Shp2 deleted in POMC neurons (Shp2/Pomc-cre) and control mice (Shp2(flox/flox)) were implanted with telemetry probes and venous catheters for measurement of mean arterial pressure (MAP) and leptin infusion. After at least 5 days of stable control measurements, mice received leptin infusion (2 μg·kg(-1)·day(-1) iv) for 7 days. Compared with Shp2(flox/flox) controls, Shp2/Pomc-cre mice at 22 wk of age were slightly heavier (34 ± 1 vs. 31 ± 1 g) but consumed a similar amount of food (3.9 ± 0.3 vs. 3.8 ± 0.2 g/day). Leptin infusion reduced food intake in Shp2(flox/flox) mice (2.6 ± 0.5 g) and Shp2/Pomc-cre mice (3.2 ± 0.3 g). Despite decreasing food intake, leptin infusion increased MAP in control mice, whereas no significant change in MAP was observed in Shp2/Pomc-cre mice. Leptin infusion also decreased plasma glucose and insulin levels in controls (12 ± 1 to 6 ± 1 μU/ml and 142 ± 12 to 81 ± 8 mg/100 ml) but not in Shp2/Pomc-cre mice. Leptin increased V̇o2 by 16 ± 2% in controls and 7 ± 1% in Shp2/Pomc-cre mice. These results indicate that Shp2 signaling in POMC neurons contributes to the long-term BP and antidiabetic actions of leptin and may play a modest role in normal regulation of body weight. Copyright © 2014 the American Physiological Society.

  9. Norwegian hydropower a valuable peak power source

    Energy Technology Data Exchange (ETDEWEB)

    Brekke, Hermod

    2010-07-01

    Full text: The paper gives a historical technical review of the development and installation of approximately 20 000 MW of hydraulic turbines in Norway after World War II. The non polluting production of electricity was consumed for lightening and heating for civil consume and the growing electric furnace industry in Norway in addition to export in rainy years. The paper is mainly based on the authors experience in the design of large turbines, and control systems for operation of Francis Turbines and Reversible Pump Turbines for high and medium heads and Pelton turbines for high heads. During the last 15 years the development of small hydro power plants has also given an increasing contribution to the power production. A brief discussion will be given on the choice of equipment for small hydro production with a very small winter production and overload during the summer. The possibility of operation of a small hydropower plants connected to an isolated grid will also briefly be presented. In addition to the general design of turbines and control systems for large hydro plants, a detailed description will be given of the stability analysis for the governing system which was developed for the large high head plants with long high pressure tunnels systems. A discussion will be included on the introduction of the air cushioned surge chambers for fast stable operation of power plants with long tunnels, connected to isolated grids. Also the principle of stabilizing unstable turbine governing system by means of pressure feed back systems, will be presented and discussed. A description of such system developed in 1992, will be given proving that stability could be obtained in a system with long conduits connected to the turbines. However, the 'governing speed' needed for isolated operation could not be fulfilled without a fast by pass pressure relieve system for Francis turbines, which was not installed in the case for the analysis. Finally a discussion will be

  10. Hydropower research programme 2008 - 2011; Forschungsprogramm Wasserkraft 2008 - 2011. Schlussbericht zur Entwicklung eines Forschungsprogramms. Aktualisierte Fortschreibung vom September 2008

    Energy Technology Data Exchange (ETDEWEB)

    Jorde, K.

    2007-07-01

    This revised final report on the development of a research programme for the Swiss Federal Office of Energy (SFOE) describes the proposals for the development of a concept for Swiss hydropower research activities for the period 2008 - 2011. According to the authors, the new research programme will not only include activities in the small hydropower area, but rather all aspects of hydropower usage, including dams and large hydropower stations. The results of a survey made concerning research and further education in the hydropower area are discussed. These results formed the basis of the new concept. The report also presents a review of the present situation with regard to hydrological questions and dams as well as mechanical and electrical equipment. The education and training of professionals is looked at and national and international co-operation in the hydropower area is also discussed. Future developments are looked at, as are the economic aspects of the use of hydropower. Measures to be taken in the research area are proposed.

  11. Peak Operation of Cascaded Hydropower Plants Serving Multiple Provinces

    Directory of Open Access Journals (Sweden)

    Jianjian Shen

    2015-10-01

    Full Text Available The bulk hydropower transmission via trans-provincial and trans-regional power networks in China provides great operational flexibility to dispatch power resources between multiple power grids. This is very beneficial to alleviate the tremendous peak load pressure of most provincial power grids. This study places the focus on peak operations of cascaded hydropower plants serving multiple provinces under a regional connected AC/DC network. The objective is to respond to peak loads of multiple provincial power grids simultaneously. A two-stage search method is developed for this problem. In the first stage, a load reconstruction strategy is proposed to combine multiple load curves of power grids into a total load curve. The purpose is to deal with different load features in load magnitudes, peaks and valleys. A mutative-scale optimization method is then used to determine the generation schedules of hydropower plants. In the second stage, an exterior point search method is established to allocate the generation among multiple receiving power grids. This method produces an initial solution using the load shedding algorithm, and further improves it by iteratively coordinating the generation among different power grids. The proposed method was implemented to the operations of cascaded hydropower plants on Xin-Fu River and another on Hongshui River. The optimization results in two cases satisfied the peak demands of receiving provincial power grids. Moreover, the maximum load difference between peak and valley decreased 12.67% and 11.32% in Shanghai Power Grid (SHPG and Zhejiang Power Grid (ZJPG, exceeding by 4.85% and 6.72% those of the current operational method, respectively. The advantage of the proposed method in alleviating peak-shaving pressure is demonstrated.

  12. Sustainability of hydropower as source of renewable and clean energy

    International Nuclear Information System (INIS)

    Luis, J; Sidek, L M; Desa, M N M; Julien, P Y

    2013-01-01

    Hydroelectric energy has been in recent times placed as an important future source of renewable and clean energy. The advantage of hydropower as a renewable energy is that it produces negligible amounts of greenhouse gases, it stores large amounts of electricity at low cost and it can be adjusted to meet consumer demand. This noble vision however is becoming more challenging due to rapid urbanization development and increasing human activities surrounding the catchment area. Numerous studies have shown that there are several contributing factors that lead towards the loss of live storage in reservoir, namely geology, ground slopes, climate, drainage density and human activities. Sediment deposition in the reservoir particularly for hydroelectric purposes has several major concerns due to the reduced water storage volume which includes increase in the risk of flooding downstream which directly effects the safety of human population and properties, contributes to economic losses not only in revenue for power generation but also large capital and maintenance cost for reservoir restorations works. In the event of functional loss of capabilities of a hydropower reservoir as a result of sedimentation or siltation could lead to both economical and environmental impact. The objective of this paper is aimed present the importance of hydropower as a source of renewable and clean energy in the national energy mix and the increasing challenges of sustainability.

  13. Treatise on water hammer in hydropower standards and guidelines

    International Nuclear Information System (INIS)

    Bergant, A; Mazij, J; Karney, B; Pejović, S

    2014-01-01

    This paper reviews critical water hammer parameters as they are presented in official hydropower standards and guidelines. A particular emphasize is given to a number of IEC standards and guidelines that are used worldwide. The paper critically assesses water hammer control strategies including operational scenarios (closing and opening laws), surge control devices (surge tank, pressure regulating valve, flywheel, etc.), redesign of the water conveyance system components (tunnel, penstock), or limitation of operating conditions (limited operating range) that are variably covered in standards and guidelines. Little information is given on industrial water hammer models and solutions elsewhere. These are briefly introduced and discussed in the light of capability (simple versus complex systems), availability of expertise (in house and/or commercial) and uncertainty. The paper concludes with an interesting water hammer case study referencing the rules and recommendations from existing hydropower standards and guidelines in a view of effective water hammer control. Recommendations are given for further work on development of a special guideline on water hammer (hydraulic transients) in hydropower plants

  14. Treatise on water hammer in hydropower standards and guidelines

    Science.gov (United States)

    Bergant, A.; Karney, B.; Pejović, S.; Mazij, J.

    2014-03-01

    This paper reviews critical water hammer parameters as they are presented in official hydropower standards and guidelines. A particular emphasize is given to a number of IEC standards and guidelines that are used worldwide. The paper critically assesses water hammer control strategies including operational scenarios (closing and opening laws), surge control devices (surge tank, pressure regulating valve, flywheel, etc.), redesign of the water conveyance system components (tunnel, penstock), or limitation of operating conditions (limited operating range) that are variably covered in standards and guidelines. Little information is given on industrial water hammer models and solutions elsewhere. These are briefly introduced and discussed in the light of capability (simple versus complex systems), availability of expertise (in house and/or commercial) and uncertainty. The paper concludes with an interesting water hammer case study referencing the rules and recommendations from existing hydropower standards and guidelines in a view of effective water hammer control. Recommendations are given for further work on development of a special guideline on water hammer (hydraulic transients) in hydropower plants.

  15. Hydropower and sustainability: resilience and vulnerability in China's powersheds.

    Science.gov (United States)

    McNally, Amy; Magee, Darrin; Wolf, Aaron T

    2009-07-01

    Large dams represent a whole complex of social, economic and ecological processes, perhaps more than any other large infrastructure project. Today, countries with rapidly developing economies are constructing new dams to provide energy and flood control to growing populations in riparian and distant urban communities. If the system is lacking institutional capacity to absorb these physical and institutional changes there is potential for conflict, thereby threatening human security. In this paper, we propose analyzing sustainability (political, socioeconomic, and ecological) in terms of resilience versus vulnerability, framed within the spatial abstraction of a powershed. The powershed framework facilitates multi-scalar and transboundary analysis while remaining focused on the questions of resilience and vulnerability relating to hydropower dams. Focusing on examples from China, this paper describes the complex nature of dams using the sustainability and powershed frameworks. We then analyze the roles of institutions in China to understand the relationships between power, human security and the socio-ecological system. To inform the study of conflicts over dams China is a particularly useful case study because we can examine what happens at the international, national and local scales. The powershed perspective allows us to examine resilience and vulnerability across political boundaries from a dynamic, process-defined analytical scale while remaining focused on a host of questions relating to hydro-development that invoke drivers and impacts on national and sub-national scales. The ability to disaggregate the affects of hydropower dam construction from political boundaries allows for a deeper analysis of resilience and vulnerability. From our analysis we find that reforms in China's hydropower sector since 1996 have been motivated by the need to create stability at the national scale rather than resilient solutions to China's growing demand for energy and water

  16. Inhibition of Estrogen Receptor Action by the Orphan Receptors, SHP and DAX-1

    National Research Council Canada - National Science Library

    DiRenzo, James

    2002-01-01

    In support of DoD grant # DAMD17-99-1-9163, we present our progress towards understanding the function of mechanisms of action of two orphan nuclear receptors, SHP and DAX-I as inhibitors of ER alpha and ER beta action...

  17. Inhibition of Estrogen Receptor Action by the Orphan Receptors, SHP and DAX-1

    National Research Council Canada - National Science Library

    DiRenzo, James

    2003-01-01

    .... In support of DoD grant # DAMD17-99-1-9163, we present our findings regarding the mechanisms by which two orphan nuclear receptors, SHP and DAX-1 inhibit the actions of ER-alpha and ER-beta action...

  18. Fuel Cycle Cost Calculations for a 120,000 shp PWR for Ship Propulsion. RCN Report

    International Nuclear Information System (INIS)

    Dekker, N.H.; Foggi, C.; Giacomazzi, G.

    1972-02-01

    A parametric study of the fuel cycle costs for a 120,000 SHP PWR for ship propulsion has been carried out. Variable parameters are: fuel pellet diameter, moderating ratio and refuelling scheme. Minimum fuel cycle costs can be obtained at moderating ratios of about 2.2. Both fuel cycle costs and reactor control requirements favour the two batch core. (author)

  19. Small heterodimer partner (SHP deficiency protects myocardia from lipid accumulation in high fat diet-fed mice.

    Directory of Open Access Journals (Sweden)

    Jung Hun Ohn

    Full Text Available The small heterodimer partner (SHP regulates fatty acid oxidation and lipogenesis in the liver by regulating peroxisome proliferator-activated receptor (PPAR γ expression. SHP is also abundantly expressed in the myocardium. We investigated the effect of SHP expression on myocardia assessing not only heart structure and function but also lipid metabolism and related gene expression in a SHP deletion animal model. Transcriptional profiling with a microarray revealed that genes participating in cell growth, cytokine signalling, phospholipid metabolism, and extracellular matrix are up-regulated in the myocardia of SHP knockout (KO mice compared to those of wild-type (WT mice (nominal p value < 0.05. Consistent with these gene expression changes, the left ventricular masses of SHP KO mice were significantly higher than WT mice (76.8 ± 20.5 mg vs. 52.8 ± 6.8 mg, P = 0.0093. After 12 weeks of high fat diet (HFD, SHP KO mice gained less weight and exhibited less elevation in serum-free fatty acid and less ectopic lipid accumulation in the myocardium than WT mice. According to microarray analysis, genes regulated by PPARγ1 and PPARα were down-regulated in myocardia of SHP KO mice compared to their expression in WT mice after HFD, suggesting that the reduction in lipid accumulation in the myocardium resulted from a decrease in lipogenesis regulated by PPARγ. We confirmed the reduced expression of PPARγ1 and PPARα target genes such as CD36, medium-chain acyl-CoA dehydrogenase, long-chain acyl-CoA dehydrogenase, and very long-chain acyl-CoA dehydrogenase by SHP KO after HFD.

  20. Shp-1 dephosphorylates TRPV1 in dorsal root ganglion neurons and alleviates CFA-induced inflammatory pain in rats.

    Science.gov (United States)

    Xiao, Xing; Zhao, Xiao-Tao; Xu, Ling-Chi; Yue, Lu-Peng; Liu, Feng-Yu; Cai, Jie; Liao, Fei-Fei; Kong, Jin-Ge; Xing, Guo-Gang; Yi, Ming; Wan, You

    2015-04-01

    Transient receptor potential vanilloid 1 (TRPV1) receptors are expressed in nociceptive neurons of rat dorsal root ganglions (DRGs) and mediate inflammatory pain. Nonspecific inhibition of protein-tyrosine phosphatases (PTPs) increases the tyrosine phosphorylation of TRPV1 and sensitizes TRPV1. However, less is known about tyrosine phosphorylation's implication in inflammatory pain, compared with that of serine/threonine phosphorylation. Src homology 2 domain-containing tyrosine phosphatase 1 (Shp-1) is a key phosphatase dephosphorylating TRPV1. In this study, we reported that Shp-1 colocalized with and bound to TRPV1 in nociceptive DRG neurons. Shp-1 inhibitors, including sodium stibogluconate and PTP inhibitor III, sensitized TRPV1 in cultured DRG neurons. In naive rats, intrathecal injection of Shp-1 inhibitors increased both TRPV1 and tyrosine-phosphorylated TRPV1 in DRGs and induced thermal hyperalgesia, which was abolished by pretreatment with TRPV1 antagonists capsazepine, BCTC, or AMG9810. Complete Freund's adjuvant (CFA)-induced inflammatory pain in rats significantly increased the expression of Shp-1, TRPV1, and tyrosine-phosphorylated TRPV1, as well as the colocalization of Shp-1 and TRPV1 in DRGs. Intrathecal injection of sodium stibogluconate aggravated CFA-induced inflammatory pain, whereas Shp-1 overexpression in DRG neurons alleviated it. These results suggested that Shp-1 dephosphorylated and inhibited TRPV1 in DRG neurons, contributing to maintain thermal nociceptive thresholds in normal rats, and as a compensatory mechanism, Shp-1 increased in DRGs of rats with CFA-induced inflammatory pain, which was involved in protecting against excessive thermal hyperalgesia.

  1. Advanced inflow forecasting for a hydropower plant in an Alpine hydropower regulated catchment - coupling of operational and hydrological forecasts

    Science.gov (United States)

    Tilg, Anna-Maria; Schöber, Johannes; Huttenlau, Matthias; Messner, Jakob; Achleitner, Stefan

    2017-04-01

    Hydropower is a renewable energy source which can help to stabilize fluctuations in the volatile energy market. Especially pumped-storage infrastructures in the European Alps play an important role within the European energy grid system. Today, the runoff of rivers in the Alps is often influenced by cascades of hydropower infrastructures where the operational procedures are triggered by energy market demands, water deliveries and flood control aspects rather than by hydro-meteorological variables. An example for such a highly hydropower regulated river is the catchment of the river Inn in the Eastern European Alps, originating in the Engadin (Switzerland). A new hydropower plant is going to be built as transboundary project at the boarder of Switzerland and Austria using the water of the Inn River. For the operation, a runoff forecast to the plant is required. The challenge in this case is that a high proportion of runoff is turbine water from an upstream situated hydropower cascade. The newly developed physically based hydrological forecasting system is mainly capable to cover natural hydrological runoff processes caused by storms and snow melt but can model only a small degree of human impact. These discontinuous parts of the runoff downstream of the pumped storage are described by means of an additional statistical model which has been developed. The main goal of the statistical model is to forecast the turbine water up to five days in advance. The lead time of the data driven model exceeds the lead time of the used energy production forecast. Additionally, the amount of turbine water is linked to the need of electricity production and the electricity price. It has been shown that especially the parameters day-ahead prognosis of the energy production and turbine inflow of the previous week are good predictors and are therefore used as input parameters for the model. As the data is restricted due to technical conditions, so-called Tobit models have been used to

  2. Advanced hydropower turbine: AHTS-Advanced Hydropower Turbine System Program; Turbinas hidraulicas avancadas: Programa AHTS-Advanced Hydropower Turbine System

    Energy Technology Data Exchange (ETDEWEB)

    Macorin, Adriano De Figueiredo; Tomisawa, Alessandra Terumi; Van Deursen, Gustavo Jose Ferreira; Bermann, Celio [Universidade de Sao Paulo (USP), SP (Brazil)], email: brunosilva@usp.br

    2010-07-01

    Due to a privileged hydrography and energy policies that remounts to the beginning of the 20th century, Brazilian's electrical grid can be considered one of the cleanest in the world regarding the emission of atmospheric pollutants. Nevertheless, as in every human large enterprise, it is well known that hydroelectric power plants also lead to harmful environmental impacts. This article presents the AHTS Program (Advanced Hydropower Turbine System) started in 1994 in USA and developed to assess and conceive new hydro turbines to mitigate two of the main negative impacts of the installation and operation of this kind of power plant: (a) turbine-passed fish mortality and (b) the low dissolved oxygen - DO - levels downstream of the dams. The criteria used to concept the turbines are also justified in this article. As well as the modifications made in each case by the following companies: Alden Research Lab e o Northern Research and Engineering Corporation (ARL/NREC) and Voith Hydro (Voith). (author)

  3. Loss of PTEN causes SHP2 activation, making lung cancer cells unresponsive to IFN-γ

    Energy Technology Data Exchange (ETDEWEB)

    Chen, Chia-Ling [Translational Research Center, Taipei Medical University, Taipei 110, Taiwan (China); Chiang, Tzu-Hui; Tseng, Po-Chun [Institute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan (China); Wang, Yu-Chih [Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan (China); Lin, Chiou-Feng, E-mail: cflin2014@tmu.edu.tw [Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan (China); Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan (China)

    2015-10-23

    Src homology-2 domain-containing phosphatase (SHP) 2, an oncogenic phosphatase, inhibits type II immune interferon (IFN)-γ signaling by subverting signal transducers and activators of transcription 1 tyrosine phosphorylation and activation. For cancer immunoediting, this study aimed to investigate the decrease of phosphatase and tensin homolog deleted on chromosome 10 (PTEN), a tumor suppressor protein, leading to cellular impairment of IFN-γ signaling. In comparison with human lung adenocarcinoma A549 cells, the natural PTEN loss in another human lung adenocarcinoma line, PC14PE6/AS2 cells, presents reduced responsiveness in IFN-γ-induced IFN regulatory factor 1 activation and CD54 expression. Artificially silencing PTEN expression in A549 cells also caused cells to be unresponsive to IFN-γ without affecting IFN-γ receptor expression. IFN-γ-induced inhibition of cell proliferation and cytotoxicity were demonstrated in A549 cells but were defective in PC14PE6/AS2 cells and in PTEN-deficient A549 cells. Aberrant activation of SHP2 by ROS was specifically shown in PC14PE6/AS2 cells and PTEN-deficient A549 cells. Inhibiting ROS and SHP2 rescued cellular responses to IFN-γ-induced cytotoxicity and inhibition of cell proliferation in PC14PE6/AS2 cells. These results demonstrate that a decrease in PTEN facilitates ROS/SHP2 signaling, causing lung cancer cells to become unresponsive to IFN-γ. - Highlights: • This study demonstrates that PTEN decrease causes cellular unresponsive to IFN-γ. • Lung cancer cells with PTEN deficiency show unresponsive to IFN-γ signaling. • PTEN decrease inhibits IFN-γ-induced CD54, cell proliferation inhibition, and cytotoxicity. • ROS-mediated SHP2 activation makes PTEN-deficient cells unresponsive to IFN-γ.

  4. Kaempferol suppresses collagen-induced platelet activation by inhibiting NADPH oxidase and protecting SHP-2 from oxidative inactivation.

    Science.gov (United States)

    Wang, Su Bin; Jang, Ji Yong; Chae, Yun Hee; Min, Ji Hyun; Baek, Jin Young; Kim, Myunghee; Park, Yunjeong; Hwang, Gwi Seo; Ryu, Jae-Sang; Chang, Tong-Shin

    2015-06-01

    Reactive oxygen species (ROS) generated upon collagen stimulation act as second messengers to propagate various platelet-activating events. Among the ROS-generating enzymes, NADPH oxidase (NOX) plays a prominent role in platelet activation. Thus, NOX has been suggested as a novel target for anti-platelet drug development. Although kaempferol has been identified as a NOX inhibitor, the influence of kaempferol on the activation of platelets and the underlying mechanism have never been investigated. Here, we studied the effects of kaempferol on NOX activation, ROS-dependent signaling pathways, and functional responses in collagen-stimulated platelets. Superoxide anion generation stimulated by collagen was significantly inhibited by kaempferol in a concentration-dependent manner. More importantly, kaempferol directly bound p47(phox), a major regulatory subunit of NOX, and significantly inhibited collagen-induced phosphorylation of p47(phox) and NOX activation. In accordance with the inhibition of NOX, ROS-dependent inactivation of SH2 domain-containing protein tyrosine phosphatase-2 (SHP-2) was potently protected by kaempferol. Subsequently, the specific tyrosine phosphorylation of key components (Syk, Vav1, Btk, and PLCγ2) of collagen receptor signaling pathways was suppressed by kaempferol. Kaempferol also attenuated downstream responses, including cytosolic calcium elevation, P-selectin surface exposure, and integrin-αIIbβ3 activation. Ultimately, kaempferol inhibited platelet aggregation and adhesion in response to collagen in vitro and prolonged in vivo thrombotic response in carotid arteries of mice. This study shows that kaempferol impairs collagen-induced platelet activation through inhibition of NOX-derived ROS production and subsequent oxidative inactivation of SHP-2. This effect suggests that kaempferol has therapeutic potential for the prevention and treatment of thrombovascular diseases. Copyright © 2015 Elsevier Inc. All rights reserved.

  5. Modelling the feasibility of retrofitting hydropower to existing South ...

    African Journals Online (AJOL)

    sources (including nuclear energy) will be nearly 30% (Eskom,. 2011). South Africa ... Hydropower has the following advantages over other forms of .... well as negative environmental impacts. ... Potential environmental impacts of hydropower.

  6. Hydropower planning coordinated with wind power in areas with congestion problems for trading on the spot and the regulating market

    International Nuclear Information System (INIS)

    Matevosyan, Julija; Olsson, Magnus; Soeder, Lennart

    2009-01-01

    In this paper a day-ahead planning algorithm for a multi-reservoir hydropower system coordinated with wind power is developed. Coordination applies to real situations, where wind power and hydropower are owned by different utilities, sharing the same transmission lines, though hydropower has priority for transmission capacity. Coordination is thus necessary to minimize wind energy curtailments during congestion situations. The planning algorithm accounts for the uncertainty of wind power forecasts and power market price uncertainty. Planning for the spot market and the regulating market is considered in the algorithm. The planning algorithm is applied to a case study and the results are summarized in the paper. (author)

  7. An estimation of the Swiss hydropower rent

    International Nuclear Information System (INIS)

    Banfi, Silvia; Filippini, Massimo; Mueller, Adrian

    2005-01-01

    The electricity generation in Switzerland is mostly based on hydropower (∼58%) and nuclear power (∼38%). The exploitation of water in the hydropower sector can generate significant economic rent. One possibility to capture this rent is through royalties or fees. This system has been used in Switzerland since many decades. However, the actual water fee system is not flexible and does not take into consideration different production costs between the type and location of hydropower plants. Furthermore, storage plants can sell electricity to a higher price than run-of-river plants. A flexible system is needed in a liberalized electricity market, to take into account these different production situations and the fact that prices may vary considerably over time. The main goal of this paper is to calculate the potential economic rent that could be generated in the Swiss hydropower sector under a future liberalized market. Based on the results of the paper, it can be concluded that the introduction of a flexible fee system could improve the competitiveness of the hydropower sector and promote an energy system based on renewable energy sources

  8. The potential of hydropower - Scenarios in the area of conflict between the economy and politics

    International Nuclear Information System (INIS)

    Groetzinger, S.

    2006-01-01

    This article takes a look at how hydropower in Switzerland has developed over the years and the potential for its further use in the future. The article reviews developments in the use of hydropower in Switzerland over the years and discusses the possibilities that still exist for increasing the amount of power produced. Details on the various estimates of production potential are quoted for the period up to 2050. Both technical and ecological aspects are reviewed. Diagrams and tables provide data on the subject. The development of the various scenarios is described. The total potential of hydropower and the development of a strategy for the use of this CO 2 -neutral form of energy are briefly discussed

  9. The potential micro-hydropower projects in Nakhon Ratchasima province, Thailand

    International Nuclear Information System (INIS)

    Kosa, Preeyaphorn; Chinkulkijniwat, Avirut; Horpibulsuk, Suksun; Kulworawanichpong, Thanatchai; Srivoramas, Rerkchai; Teaumroong, Neung

    2011-01-01

    At present, fossil fuel energy is commonly used in developing countries, including Thailand. The tendency to use fossil fuel energy is continuously increasing, and the price of fossil fuels is rising. Thus, renewable energy is of interest. Hydropower is one of the oldest renewable energy forms known and one of the best solutions for providing electricity to rural communities. The present paper aims to determine the potential micro-hydropower sites that could provide more than 50 kW but not over 10 MW in Nakhon Ratchasima Province, Thailand. Both reservoir and run-of-the-river schemes are considered for the assessment of potential micro-hydropower sites. For the reservoir scheme, the discharge in the reservoir is employed for generating micro-hydropower electricity. This installation can be carried out without major modifications to the dam. The run-of-the-river scheme diverts water flow from the river mainstream to the intake via a pressure pipe or an open canal, which is then conveyed to the turbine via a penstock to generate electricity. The results showed that there are 6 suitable projects for the reservoir scheme and 11 suitable projects for the run-of-the-river. The maximum power load was 6000 kW and 320 kW for the reservoir and the run-of-the-river schemes, respectively. Hydropower from the run-of-the-river scheme is more suitable than hydropower from the reservoir scheme because of the many mountains in this province. The designed head for the run-of-the-river scheme is thus generally higher than that for the reservoir scheme. Because stream flow during the dry season is very low, electricity can only be produced in the wet season. This research is a pilot study to determine the potential sites of micro-hydropower projects. (author)

  10. Framing hydropower as green energy: assessing drivers, risks and tensions in the Eastern Himalayas

    Science.gov (United States)

    Ahlers, R.; Budds, J.; Joshi, D.; Merme, V.; Zwarteveen, M.

    2015-04-01

    The culturally and ecologically diverse region of the Eastern Himalayas is the target of ambitious hydropower development plans. Policy discourses at national and international levels position this development as synergistically positive: it combines the production of clean energy to fuel economic growth at regional and national levels with initiatives to lift poor mountain communities out of poverty. Different from hydropower development in the 20th century in which development agencies and banks were important players, contemporary initiatives importantly rely on the involvement of private actors, with a prominent role of the private finance sector. This implies that hydropower development is not only financially viable but also understood as highly profitable. This paper examines the new development of hydropower in the Eastern Himalayas of Nepal and India. It questions its framing as green energy, interrogates its links with climate change, and examines its potential for investment and capital accumulation. To do this, we also review the evidence on the extent to which its construction and operation may modify existing hydrogeological processes and ecosystems, as well as its impacts on the livelihoods of diverse groups of people that depend on these. The paper concludes that hydropower development in the region is characterized by inherent contentions and uncertainties, refuting the idea that dams constitute development projects whose impacts can be simply predicted, controlled and mitigated. Indeed, in a highly complex geological, ecological, cultural and political context that is widely regarded to be especially vulnerable to the effects of climate change, hydropower as a development strategy makes for a toxic cocktail.

  11. Value of ecosystem hydropower service and its impact on the payment for ecosystem services.

    Science.gov (United States)

    Fu, B; Wang, Y K; Xu, P; Yan, K; Li, M

    2014-02-15

    Hydropower is an important service provided by ecosystems. We surveyed all the hydropower plants in the Zagunao River Basin, Southwest China. Then, we assessed the hydropower service by using the InVEST (The Integrated Value and Tradeoff of Ecosystem Service Tools) model. Finally, we discussed the impact on ecological compensation. The results showed that: 1) hydropower service value of ecosystems in the Zagunao River Basin is 216.29 Euro/hm(2) on the average, of which the high-value area with more than 475.65 Euro/hm(2) is about 750.37 km(2), accounting for 16.12% of the whole watershed, but it provides 53.47% of the whole watershed service value; 2) ecosystem is an ecological reservoir with a great regulation capacity. Dams cannot completely replace the reservoir water conservation function of ecosystems, and has high economic and environmental costs that must be paid as well. Compensation for water conservation services should become an important basis for ecological compensation of hydropower development. 3) In the current PES cases, the standard of compensation is generally low. Cascade development makes the value of upstream ecosystem services become more prominent, reflecting the differential rent value, and the value of ecosystem services should be based on the distribution of differentiated ecological compensation. Copyright © 2013 Elsevier B.V. All rights reserved.

  12. Swiss hydropower in competition - an analysis with reference to the future European power supply system

    International Nuclear Information System (INIS)

    Balmer, M.; Spreng, D.; Moest, D.

    2006-01-01

    This article takes a look at a number of questions in relation to the future use of Swiss hydropower that are neither clear nor unchallenged. Questions concerning the replacement or refurbishment of hydropower schemes that will have to be renewed in the next few years are asked. Also, developments in the European power market are looked at. The future influence of wind power, trading with CO 2 certificates, increases in the price of gas etc. are examined. An analysis of the competitiveness of Swiss hydropower with reference to the European power supply system that was made by the Centre for Energy Policy and Economics CEPE at the Swiss Federal Institute of Technology ETH is described. The 'Perseus'-model developed by CEPE and the Industrial Technology Institute at the University of Karlsruhe in Germany is used to analyse possible developments over the period up to 2030. The results are presented in graphical form and commented on

  13. Alleviating dam impacts along the transboundary Se San River in northeast Cambodia : a review of the rapid environmental impact assessment on the Cambodian part of the Se San River due to hydropower development in Vietnam (July 2007 version)

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2008-02-15

    Probe International has reviewed 2 reports regarding the environmental impact assessment (EIA) on the Cambodian part of the Se San River resulting from hydropower development in Vietnam. Both reports were prepared for Electricity of Vietnam (EVN), the project owner and developer. The operation of 3 large hydro dams on the upper Se San River has disrupted flow in downstream Cambodia where more than 28,000 people depend on the river for drinking water, irrigation, fishing, livestock watering and transportation. Probe International's focus is on mitigating and compensating for affected communities in downstream Cambodia. Their review of the EIAs recommends that Electricity of Vietnam consider switching from peaking to base load operations at its upper Se San hydro dams to mitigate the impacts in downstream Cambodia. The downstream impacts of EVN dams on the Se San River include loss of life, property, livelihood and habitat; malnutrition; loss of wet season rice production; reduced fish catches; food security at risk; loss of fish protein; loss of river bank agriculture; reduced availability of plants for food and medicine; river bank erosion; reservoir erosion and downstream turbidity; increased transportation risks; loss of fisheries habitat; increased pressure on upland forests; disrupted riverine ecosystem; and disrupted fish migration. The EIA recommendations include the re-regulation of the Se San 4A reservoir; operational changes to reduce downstream fluctuations and erosion; monitoring impact of operations on water quantity and quality downstream; algal monitoring; establishment of early warning system for spillway release; prolonging the wet season filling of the reservoir; reducing nutrient inputs to the rivers and reservoirs and a fish stocking program. 6 figs., 1 appendix.

  14. The sustainability of hydropower projects in Brazil

    Energy Technology Data Exchange (ETDEWEB)

    de Methodio Maranhao Neto, Gil; Yana, Laurent

    2010-09-15

    The construction of hydropower plants unquestionably impacts the environment and communities. But countries such as Brazil have been able to build up a sophisticated socio-environmental legislation and institutions as well as a democratic and participative licensing process to protect the nature and the population affected. In some cases, plants greatly contribute towards the creation of local welfare to the population as well as good environmental practices. As a good example of best practices on socio-environmental standards, we will analyze Jirau Hydropower Project, currently under construction on the Madeira River, north of Brazil.

  15. The use of public participation and economic appraisal for public involvement in large-scale hydropower projects: Case study of the Nam Theun 2 Hydropower Project

    International Nuclear Information System (INIS)

    Mirumachi, Naho; Torriti, Jacopo

    2012-01-01

    Gaining public acceptance is one of the main issues with large-scale low-carbon projects such as hydropower development. It has been recommended by the World Commission on Dams that to gain public acceptance, public involvement is necessary in the decision-making process (). As financially-significant actors in the planning and implementation of large-scale hydropower projects in developing country contexts, the paper examines the ways in which public involvement may be influenced by international financial institutions. Using the case study of the Nam Theun 2 Hydropower Project in Laos, the paper analyses how public involvement facilitated by the Asian Development Bank had a bearing on procedural and distributional justice. The paper analyses the extent of public participation and the assessment of full social and environmental costs of the project in the Cost-Benefit Analysis conducted during the project appraisal stage. It is argued that while efforts were made to involve the public, there were several factors that influenced procedural and distributional justice: the late contribution of the Asian Development Bank in the project appraisal stage; and the issue of non-market values and discount rate to calculate the full social and environmental costs. - Highlights: ► Public acceptance in large-scale hydropower projects is examined. ► Both procedural and distributional justice are important for public acceptance. ► International Financial Institutions can influence the level of public involvement. ► Public involvement benefits consideration of non-market values and discount rates.

  16. Differential Mechanisms for SHP2 Binding and Activation Are Exploited by Geographically Distinct Helicobacter pylori CagA Oncoproteins

    Directory of Open Access Journals (Sweden)

    Takeru Hayashi

    2017-09-01

    Full Text Available Helicobacter pylori East Asian CagA is more closely associated with gastric cancer than Western CagA. Here we show that, upon tyrosine phosphorylation, the East Asian CagA-specific EPIYA-D segment binds to the N-SH2 domain of pro-oncogenic SHP2 phosphatase two orders of magnitude greater than Western CagA-specific EPIYA-C. This high-affinity binding is achieved via cryptic interaction between Phe at the +5 position from phosphotyrosine in EPIYA-D and a hollow on the N-SH2 phosphopeptide-binding floor. Also, duplication of EPIYA-C in Western CagA, which increases gastric cancer risk, enables divalent high-affinity binding with SHP2 via N-SH2 and C-SH2. These strong CagA bindings enforce enzymatic activation of SHP2, which endows cells with neoplastic traits. Mechanistically, N-SH2 in SHP2 is in an equilibrium between stimulatory “relaxed” and inhibitory “squeezed” states, which is fixed upon high-affinity CagA binding to the “relaxed” state that stimulates SHP2. Accordingly, East Asian CagA and Western CagA exploit distinct mechanisms for SHP2 deregulation.

  17. Quantifying the Value of Hydropower in the Electric Grid: Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Key, T. [Electric Power Research Inst. (EPRI), Knovville, TN (United States); Rogers, L. [Electric Power Research Inst. (EPRI), Knovville, TN (United States); Brooks, D. [Electric Power Research Inst. (EPRI), Knovville, TN (United States); Tuohy, A. [Electric Power Research Inst. (EPRI), Knovville, TN (United States)

    2012-12-31

    The report summarizes research to Quantify the Value of Hydropower in the Electric Grid. This 3-year DOE study focused on defining value of hydropower assets in a changing electric grid. Methods are described for valuation and planning of pumped storage and conventional hydropower. The project team conducted plant case studies, electric system modeling, market analysis, cost data gathering, and evaluations of operating strategies and constraints. Five other reports detailing these research results are available a project website, www.epri.com/hydrogrid. With increasing deployment of wind and solar renewable generation, many owners, operators, and developers of hydropower have recognized the opportunity to provide more flexibility and ancillary services to the electric grid. To quantify value of services, this study focused on the Western Electric Coordinating Council region. A security-constrained, unit commitment and economic dispatch model was used to quantify the role of hydropower for several future energy scenarios up to 2020. This hourly production simulation considered transmission requirements to deliver energy, including future expansion plans. Both energy and ancillary service values were considered. Addressing specifically the quantification of pumped storage value, no single value stream dominated predicted plant contributions in various energy futures. Modeling confirmed that service value depends greatly on location and on competition with other available grid support resources. In this summary, ten different value streams related to hydropower are described. These fell into three categories; operational improvements, new technologies, and electricity market opportunities. Of these ten, the study was able to quantify a monetary value in six by applying both present day and future scenarios for operating the electric grid. This study confirmed that hydropower resources across the United States contribute significantly to operation of the grid in terms

  18. Modulation of fatty acid synthase degradation by concerted action of p38 MAP kinase, E3 ligase COP1, and SH2-tyrosine phosphatase Shp2.

    Science.gov (United States)

    Yu, Jianxiu; Deng, Rong; Zhu, Helen H; Zhang, Sharon S; Zhu, Changhong; Montminy, Marc; Davis, Roger; Feng, Gen-Sheng

    2013-02-08

    The Src-homology 2 (SH2) domain-containing tyrosine phosphatase Shp2 has been known to regulate various signaling pathways triggered by receptor and cytoplasmic tyrosine kinases. Here we describe a novel function of Shp2 in control of lipid metabolism by mediating degradation of fatty acid synthase (FASN). p38-phosphorylated COP1 accumulates in the cytoplasm and subsequently binds FASN through Shp2 here as an adapter, leading to FASN-Shp2-COP1 complex formation and FASN degradation mediated by ubiquitination pathway. By fasting p38 is activated and stimulates FASN protein degradation in mice. Consistently, the FASN protein levels are dramatically elevated in mouse liver and pancreas in which Shp2/Ptpn11 is selectively deleted. Thus, this study identifies a new activity for Shp2 in lipid metabolism.

  19. Climate Risk in Southern and Eastern Africa's Hydropower Generation

    Science.gov (United States)

    Dalin, C.; Conway, D.; Landman, W.; Osborn, T.

    2016-12-01

    Hydropower comprises a major proportion of electricity production in southern and eastern Africa and is undergoing rapid expansion. Hydropower production in both regions is exposed to high levels of climate variability and regional linkages are strong, yet an understanding of aggregate climate risk is lacking. Here we map regions of coherent precipitation variability with current and planned (2030) hydropower sites, river basin configuration and regional energy grids to assess aggregate exposure to hydropower supply disruption. If fully implemented hydropower will be increasingly concentrated in the Nile basin in eastern Africa and the Zambezi basin in southern Africa. Regions of similar rainfall variability show close alignment with the main sites of hydropower. Future concentration of hydropower will greatly increase the concurrent risk of climate related electricity supply disruption. Nascent electricity sharing mechanisms could mitigate risk but face considerable political and infrastructural challenges.

  20. Hydropower | Climate Neutral Research Campuses | NREL

    Science.gov (United States)

    project. Options usually include self-financing, issuing bonds, or obtaining third-party financing from how hydropower may fit into your climate action plans. Campus Options Considerations Sample Project to handle permitting issues? Does your campus need a hydraulics laboratory? Is financing available

  1. A Risk Analysis of Small-Hydro Power (SHP Plants Investments

    Directory of Open Access Journals (Sweden)

    Jorge Cunha

    2014-06-01

    Full Text Available The increase in electricity consumption has led to a sharp increase in energy demand which rose environmental and sustainability concerns. To address this issue, there has been an incentive to resource to renewable energy sources for electricity production. Departing from a real case study, the investment appraisal of a SHP project under the present market conditions is described, followed by a sensitivity analysis in order to identify the main sources of risk. The main results obtained showed that in the context of a regulated tariff the project is worthwhile due to a positive NPV. However, if electricity had to be sold at market prices, the project becomes unprofitable. Theresults put also in evidence the vulnerability of the investment to an adverse change in interest rates. Future SHP plant investments should take into account the need to operate in a free market and to compete with technologies based on fossil fuels or large hydro.

  2. Actin retrograde flow controls natural killer cell response by regulating the conformation state of SHP-1.

    Science.gov (United States)

    Matalon, Omri; Ben-Shmuel, Aviad; Kivelevitz, Jessica; Sabag, Batel; Fried, Sophia; Joseph, Noah; Noy, Elad; Biber, Guy; Barda-Saad, Mira

    2018-03-01

    Natural killer (NK) cells are a powerful weapon against viral infections and tumor growth. Although the actin-myosin (actomyosin) cytoskeleton is crucial for a variety of cellular processes, the role of mechanotransduction, the conversion of actomyosin mechanical forces into signaling cascades, was never explored in NK cells. Here, we demonstrate that actomyosin retrograde flow (ARF) controls the immune response of primary human NK cells through a novel interaction between β-actin and the SH2-domain-containing protein tyrosine phosphatase-1 (SHP-1), converting its conformation state, and thereby regulating NK cell cytotoxicity. Our results identify ARF as a master regulator of the NK cell immune response. Since actin dynamics occur in multiple cellular processes, this mechanism might also regulate the activity of SHP-1 in additional cellular systems. © 2018 The Authors.

  3. Computer applications in water conservancy and hydropower engineering

    Energy Technology Data Exchange (ETDEWEB)

    Chen, J

    1984-09-20

    The use of computers in China's water conservancy and hydropower construction began in the 1960s for exploration surveys, planning, design, construction, operation, and scientific research. Despite the positive results, and the formation of a 1000-person computer computation contingent, computer development among different professions is not balanced. The weaknesses and disparities in computer applications include an overall low level of application relative to the rest of the world, which is partly due to inadequate hardware and programs. The report suggests five ways to improve applications and popularize microcomputers which emphasize leadership and planning.

  4. Short-term hydropower production planning by stochastic programming

    DEFF Research Database (Denmark)

    Fleten, Stein-Erik; Kristoffersen, Trine

    2008-01-01

    -term production planning a matter of spatial distribution among the reservoirs of the plant. Day-ahead market prices and reservoir inflows are, however, uncertain beyond the current operation day and water must be allocated among the reservoirs in order to strike a balance between current profits and expected......Within the framework of multi-stage mixed-integer linear stochastic programming we develop a short-term production plan for a price-taking hydropower plant operating under uncertainty. Current production must comply with the day-ahead commitments of the previous day which makes short...

  5. Hydrological assessment for mini hydropower potential at Sungai Pahang - Temerloh

    International Nuclear Information System (INIS)

    Sidek, L M; Zaki, A Z A; Muda, Z C; Basri, H; Mustaffa, Z; Ibrahim, M I H; Thiruchelvam, S

    2013-01-01

    Sg Pahang at Temerloh was considered for assessment of hydropower potential using hydrological analysis method and hydrological model. The available data related to topography, soil, land use, weather and discharge pertaining to the study catchment were used to characterize the catchment. The characterization was required for water resources hence hydropower assessment. The hydrology of the study catchment was simulated through the model. This hydrological study is required due to the proposed mini hydroelectric power plant at Pulau Temerloh. It is essential to evaluate the existing river flow characteristic and to model the environmental flow assessment of the river. Two rainfalll stations, JPS Temerloh and Pintu Kawalan Paya Kertam Station are selected to develop the Rainfall Intensity Duration frequency (RIDF) Curve to determine the rainfall intensity of the area. Daily river flow were recorded at Sg Pahang at Temerloh and Sg Pahang at Lubok Paku were used to develop the Flow Duration Curve (FDC) to study the characteristic of Sungai Pahang flow. The 7 days low flow with 10 years return period (7Q10 low flow) was obtained using both Gumbel Method and Log Pearson Type III Method. The results from FDC shows that 50% percentage of time the Sg Pahang - Temerloh is exceeded over a historical period is 400 m 3 /s and 50% percentage of time the Sg Pahang - Lubok Paku is exceeded over a historical period is 650 m 3 /s. The required environmental flow are set to be 7Q10 low flow which is 64.215 m 3 /s for Sg Pahang at Temerloh and 79.24 m 3 /s for Sg Pahang at Lubok Paku. The results show the water resources are abundant and hence boost the mini hydropower potentiality at Sg Pahang.

  6. An approach to the investment analysis of small and medium hydro-power plants

    DEFF Research Database (Denmark)

    Forouzbakhsh, Farshid; Hosseini, S.M.H.; Vakilian, M.

    2007-01-01

    Hydro-power plants, as a part of infrastructure projects, play an important role in the economic-social development of countries. Sincea large amount of investment is needed for construction of these power plants, which appeared to be an obstacle in these developments,however it is possible...

  7. Framing hydropower as green energy: assessing drivers, risks and tensions in the Eastern Himalayas

    NARCIS (Netherlands)

    Ahlers, R.; Budds, J.; Joshi, D.; Merme, V.; Zwarteveen, M.

    2015-01-01

    The culturally and ecologically diverse region of the Eastern Himalayas is the target of ambitious hydropower development plans. Policy discourses at national and international levels position this development as synergistically positive: it combines the production of clean energy to fuel economic

  8. Framing hydropower as green energy: assessing drivers, risks and tensions in the Eastern Himalayas

    NARCIS (Netherlands)

    Ahlers, R.; Budds, J.; Joshi, D.; Merme, V.; Zwarteveen, M.Z.

    2014-01-01

    The culturally and ecologically diverse region of the Eastern Himalayas is the target of ambitious hydropower development plans. Policy discourses at national and international levels position this development as synergistically positive: it combines the production of clean energy to fuel economic

  9. Small and medium-sized hydropower projects in competitive markets: the case of Rio Piedras

    International Nuclear Information System (INIS)

    Restrepo Posada, Federico

    1999-01-01

    The article describes the case of the Rio Piedras Hydropower Project, a first private hydropower generation initiative in Colombia, within the new regulatory framework for the provision of public services and electric generation under laws 142 and 143, passed in 1994. Reference is made in this article to the background and characteristics of the Project, and some obstacles, challenges and risks encountered are described, as well as the way in which they are being controlled. The investment and commercialization modules developed in analyzing the project are also presented. Finally, some reflections are given as to the medium and long term prospects for electric generation projects in Colombia. (The author)

  10. Matrix of risk and premium for the developing of small hydropower projects; Matriz de risco e premio para o desenvolvimento de projetos de PCHs (Pequenas Centrais Hidroeletricas)

    Energy Technology Data Exchange (ETDEWEB)

    Santos, Afonso Henriques Moreira; Garcia, Marco Aurelio R.A.; Cruz, Ricardo A. Passos da

    2008-07-01

    The aim of this paper is to propose a method for valuation of assets of small hydroelectric plants in different stages of maturation. To this end, we adopted the principle of risk premium, associated with a portion of the profitability of the project (internal rate of return-IRR) in every stage of development. In other words: the more mature the project, the lower your risk and consequently lower the corresponding premium, adopting as a total prize the IRR expected to the project.

  11. Operation of hydropower generation systems in the Alps under future climate and socio-economic drivers

    Science.gov (United States)

    Anghileri, Daniela; Castelletti, Andrea; Burlando, Paolo

    2015-04-01

    Alpine hydropower systems are an important source of renewable energy for many countries in Europe. In Switzerland, for instance, they represent the most important domestic source of renewable energy (around 55%). However, future hydropower production may be threatened by unprecedented challenges, such as a decreasing water availability, due to climate change (CC) and associated glacier retreat, and uncertain operating conditions, such as future power needs and highly fluctuating demand on the energy market. This second aspect has gained increasingly relevance since the massive introduction of solar and wind generating systems in the portfolios of many European countries. Because hydropower systems have the potential to provide backup storage of energy to compensate for fluctuations that are typical, for instance, of solar and wind generation systems, it is important to investigate how the increased demand for flexible operation, together with climate change challenge and fluctuating markets, can impact their operating policies. The Swiss Competence Center on Supply of Electricity (www.sccer-soe.ch) has been recently established to explore new potential paths for the development of future power generation systems. In this context, we develop modelling and optimization tools to design and assess new operation strategies for hydropower systems to increase their reliability, flexibility, and robustness to future operation conditions. In particular, we develop an advanced modelling framework for the integrated simulation of the operation of hydropower plants, which accounts for CC-altered streamflow regimes, new demand and market conditions, as well as new boundary conditions for operation (e.g., aquatic ecosystem conservation). The model construction consists of two primary components: a physically based and spatially distributed hydrological model, which describes the relevant hydrological processes at the basin scale, and an agent based decision model, which

  12. Demonstrating a new framework for the comparison of environmental impacts from small- and large-scale hydropower and wind power projects.

    Science.gov (United States)

    Bakken, Tor Haakon; Aase, Anne Guri; Hagen, Dagmar; Sundt, Håkon; Barton, David N; Lujala, Päivi

    2014-07-01

    Climate change and the needed reductions in the use of fossil fuels call for the development of renewable energy sources. However, renewable energy production, such as hydropower (both small- and large-scale) and wind power have adverse impacts on the local environment by causing reductions in biodiversity and loss of habitats and species. This paper compares the environmental impacts of many small-scale hydropower plants with a few large-scale hydropower projects and one wind power farm, based on the same set of environmental parameters; land occupation, reduction in wilderness areas (INON), visibility and impacts on red-listed species. Our basis for comparison was similar energy volumes produced, without considering the quality of the energy services provided. The results show that small-scale hydropower performs less favourably in all parameters except land occupation. The land occupation of large hydropower and wind power is in the range of 45-50 m(2)/MWh, which is more than two times larger than the small-scale hydropower, where the large land occupation for large hydropower is explained by the extent of the reservoirs. On all the three other parameters small-scale hydropower performs more than two times worse than both large hydropower and wind power. Wind power compares similarly to large-scale hydropower regarding land occupation, much better on the reduction in INON areas, and in the same range regarding red-listed species. Our results demonstrate that the selected four parameters provide a basis for further development of a fair and consistent comparison of impacts between the analysed renewable technologies. Copyright © 2014 The Authors. Published by Elsevier Ltd.. All rights reserved.

  13. Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interaction.

    Science.gov (United States)

    Yan, Meiping; Zhang, Xinhua; Chen, Ao; Gu, Wei; Liu, Jie; Ren, Xiaojiao; Zhang, Jianping; Wu, Xiaoxiong; Place, Aaron T; Minshall, Richard D; Liu, Guoquan

    2017-11-01

    Intercellular adhesion molecule-1 (ICAM-1) mediates the firm adhesion of leukocytes to endothelial cells and initiates subsequent signaling that promotes their transendothelial migration (TEM). Vascular endothelial (VE)-cadherin plays a critical role in endothelial cell-cell adhesion, thereby controlling endothelial permeability and leukocyte transmigration. This study aimed to determine the molecular signaling events that originate from the ICAM-1-mediated firm adhesion of neutrophils that regulate VE-cadherin's role as a negative regulator of leukocyte transmigration. We observed that ICAM-1 interacts with Src homology domain 2-containing phosphatase-2 (SHP-2), and SHP-2 down-regulation via silencing of small interfering RNA in endothelial cells enhanced neutrophil adhesion to endothelial cells but inhibited neutrophil transmigration. We also found that VE-cadherin associated with the ICAM-1-SHP-2 complex. Moreover, whereas the activation of ICAM-1 leads to VE-cadherin dissociation from ICAM-1 and VE-cadherin association with actin, SHP-2 down-regulation prevented ICAM-1-VE-cadherin association and promoted VE-cadherin-actin association. Furthermore, SHP-2 down-regulation in vivo promoted LPS-induced neutrophil recruitment in mouse lung but delayed neutrophil extravasation. These results suggest that SHP-2- via association with ICAM-1-mediates ICAM-1-induced Src activation and modulates VE-cadherin switching association with ICAM-1 or actin, thereby negatively regulating neutrophil adhesion to endothelial cells and enhancing their TEM.-Yan, M., Zhang, X., Chen, A., Gu, W., Liu, J., Ren, X., Zhang, J., Wu, X., Place, A. T., Minshall, R. D., Liu, G. Endothelial cell SHP-2 negatively regulates neutrophil adhesion and promotes transmigration by enhancing ICAM-1-VE-cadherin interaction. © FASEB.

  14. Development of a network-based information infrastructure for fisheries and hydropower information in the Columbia River Basin : Final project report; TOPICAL

    International Nuclear Information System (INIS)

    Scheibe, Timothy D.; Johnson, Gary E.; Perkins, Bill

    1997-01-01

    The goal of this project was to help develop technology and a unified structure to access and disseminate information related to the Bonneville Power Administration's fish and wildlife responsibility in the Pacific Northwest. BPA desires to increase access to, and exchange of, information produced by the Environment Fish, and Wildlife Group in concert with regional partners. Historically, data and information have been managed through numerous centralized, controlled information systems. Fisheries information has been fragmented and not widely exchanged. Where exchange has occurred, it often is not timely enough to allow resource managers to effectively use the information to guide planning and decision making. This project (and related projects) have successfully developed and piloted a network-based infrastructure that will serve as a vehicle to transparently connect existing information systems in a manner that makes information exchange efficient and inexpensive. This project was designed to provide a mechanism to help BPA address measures in the Northwest Power Planning Council's (NPPC) Fish and Wildlife program: 3.2H Disseminate Research and Monitoring Information and 5.1A.5 manage water supplies in accordance with the Annual Implementation Work Plan. This project also provided resources that can be used to assist monitoring and evaluation of the Program

  15. Development of a Network-Based Information Infrastructure for Fisheries and Hydropower Information in the Columbia River Basin : Final Project Report.

    Energy Technology Data Exchange (ETDEWEB)

    Scheibe, Timothy D.; Johnson, Gary E.; Perkins, Bill

    1997-05-01

    The goal of this project was to help develop technology and a unified structure to access and disseminate information related to the Bonneville Power Administration's fish and wildlife responsibility in the Pacific Northwest. BPA desires to increase access to, and exchange of, information produced by the Environment Fish, and Wildlife Group in concert with regional partners. Historically, data and information have been managed through numerous centralized, controlled information systems. Fisheries information has been fragmented and not widely exchanged. Where exchange has occurred, it often is not timely enough to allow resource managers to effectively use the information to guide planning and decision making. This project (and related projects) have successfully developed and piloted a network-based infrastructure that will serve as a vehicle to transparently connect existing information systems in a manner that makes information exchange efficient and inexpensive. This project was designed to provide a mechanism to help BPA address measures in the Northwest Power Planning Council's (NPPC) Fish and Wildlife program: 3.2H Disseminate Research and Monitoring Information and 5.1A.5 manage water supplies in accordance with the Annual Implementation Work Plan. This project also provided resources that can be used to assist monitoring and evaluation of the Program.

  16. Economic implications of climate-driven trends in global hydropower generation

    Science.gov (United States)

    Turner, S. W. D.; Galelli, S.; Hejazi, M. I.; Clarke, L.; Edmonds, J.; Kim, S. H.

    2017-12-01

    Recent progress in global scale hydrological and dam modeling has allowed for the study of climate change impacts on global hydropower production. Here we explore how these impacts could affect the composition of global electricity supply, and what those changes could mean for power sector emissions and investment needs in the 21st century. Regional hydropower projections are developed for two emissions scenarios by forcing a coupled global hydrological and dam model (1593 major hydropower dams; 54% global installed capacity) with downscaled, bias-corrected climate realizations derived from sixteen General Circulation Models (GCMs). To incorporate possible non-linearity in hydropower response to climate change, dam simulations incorporate plant specifications (e.g., maximum turbine flow), reservoir storage dynamics, reservoir bathymetry, evaporation losses and bespoke, site specific operations. Consequent impacts on regional and global-level electricity generation and associated emissions and investment costs are examined using the Global Change Assessment Model (GCAM). We show that changes in hydropower generation resulting from climate change can shift power demands onto and away from carbon intensive technologies, resulting in significant impacts on CO2 emissions for several regions. Many of these countries are also highly vulnerable to investment impacts (costs of new electricity generating facilities to make up for shortfalls in hydro), which in some cases amount to tens of billions of dollars by 2100. The Balkans region—typified by weak economies in a drying region that relies heavily on hydropower—emerges as the most vulnerable. Reduced impacts of climate change on hydropower production under a low emissions scenario coincide with increased costs of marginal power generating capacity (low emissions requires greater uptake of clean generating technologies, which are more expensive). This means impacts on power sector investment costs are similar for high

  17. The Economic Benefits Of Multipurpose Reservoirs In The United States- Federal Hydropower Fleet

    Energy Technology Data Exchange (ETDEWEB)

    Hadjerioua, Boualem [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Stewart, Kevin M. [Dept. of Energy (DOE), Washington DC (United States). Office of Energy Efficiency and Renewable Energy (EERE); Bonnet Acosta, Marisol [Dept. of Energy (DOE), Washington DC (United States). Office of Energy Efficiency and Renewable Energy (EERE); Mobley, Miles [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-01

    The United States is home to over 80,000 dams, of which approximately 3% are equipped with hydroelectric generating capabilities. When a dam serves as a hydropower facility, it provides a variety of energy services that range from clean, reliable power generation to load balancing that supports grid stability. In most cases, the benefits of dams and their associated reservoirs go far beyond supporting the nation s energy demand. As evidenced by the substantial presence of non-powered dams with the ability to store water in large capacities, the primary purpose of a dam may not be hydropower, but rather one of many other purposes. A dam and reservoir may support navigation, recreation, flood control, irrigation, and water supply, with each multipurpose benefit providing significant social and economic impacts on a local, regional, and national level. When hydropower is one of the services provided by a multipurpose reservoir, it is then part of an integrated system of competing uses. Operating rules, management practices, consumer demands, and environmental constraints must all be balanced to meet the multipurpose project s objectives. When federal dams are built, they are authorized by Congress to serve one or more functions. Legislation such as the Water Resources Development Act regulates the operation of the facility in order to coordinate the authorized uses and ensure the dam s intended objectives are being met. While multipurpose reservoirs account for billions of dollars in contributions to National Economic Development (NED) every year, no attempt has been made to evaluate their benefits on a national scale. This study is an on-going work conducted by Oak Ridge National Laboratory in an effort to estimate the economic benefits of multipurpose hydropower reservoirs in the United States. Given the important role that federal hydropower plays in the U.S., the first focus of this research will target the three main federal hydropower owners Tennessee Valley

  18. Interactions between land use, climate and hydropower in Scotland

    Science.gov (United States)

    Sample, James

    2015-04-01

    To promote the transition towards a low carbon economy, the Scottish Government has adopted ambitious energy targets, including generating all electricity from renewable sources by 2020. To achieve this, continued investment will be required across a range of sustainable technologies. Hydropower has a long history in Scotland and the present-day operational capacity of ~1.5 GW makes a substantial contribution to the national energy budget. In addition, there remains potential for ~500 MW of further development, mostly in the form of small to medium size run-of-river schemes. Climate change is expected to lead to an intensification of the global hydrological cycle, leading to changes in both the magnitude and seasonality of river flows. There may also be indirect effects, such as changing land use, enhanced evapotranspiration rates and an increased demand for irrigation, all of which could affect the water available for energy generation. Preliminary assessments of hydropower commonly use flow duration curves (FDCs) to estimate the power generation potential at proposed new sites. In this study, we use spatially distributed modelling to generate daily and monthly FDCs on a 1 km by 1 km grid across Scotland, using a variety of future land use and climate change scenarios. Parameter-related uncertainty in the model has been constrained using Bayesian Markov Chain Monte Carlo (MCMC) techniques to derive posterior probability distributions for key model parameters. Our results give an indication of the sensitivity and vulnerability of Scotland's run-of-river hydropower resources to possible changes in climate and land use. The effects are spatially variable and the range of uncertainty is sometimes large, but consistent patterns do emerge. For example, many locations are predicted to experience enhanced seasonality, with significantly lower power generation potential in the summer months and greater potential during the autumn and winter. Some sites may require

  19. Viewpoint – Better Management of Hydropower in an Era of Climate Change

    Directory of Open Access Journals (Sweden)

    Jamie Pittock

    2010-06-01

    Full Text Available Ten years ago the World Commission on Dams (WCD report established new standards for the sustainable development of water infrastructure, but the hopes many of us had then for a new era of more thoughtful development have been attenuated by the resilience of the hydraulic bureaucracy and the emergence of new influences on the hydropower debate. Particularly important is the impact of climate change as a driver of government policies in favour of hydropower, water storage and inter-basin water transfers. As a former Director of Freshwater for WWF International and now as a researcher on the water-energy nexus, I spent much of the past decade seeking to influence the direction of water infrastructure development, and in this viewpoint I have been asked to reflect on the changes that have occurred, and the opportunities in an era of climate change to reduce the environmental and social impacts of hydropower development while maximising the benefits. Better outcomes are more likely with a renewed focus on limiting the perverse impacts of climate change policies, implementing standards for certification of more sustainable hydropower, building capacities within developing countries, and enhancing management of existing dams.

  20. Determination of installation capacity in reservoir hydro-power plants considering technical, economical and reliability indices

    DEFF Research Database (Denmark)

    Hosseini, S.M.H.; Forouzbakhsh, Farshid; Fotouh-Firuzabad, Mahmood

    2008-01-01

    One of the most important issues in planning the ‘‘reservoir” type of hydro-power plants (HPP) is to determine the installation capacity of the HPPs and estimate its annual energy value. In this paper, a method is presented. A computer program has been developed to analyze energy calculation...

  1. Integration of Hydropower in a Competitive power market model for water-energy scenario analysis

    DEFF Research Database (Denmark)

    Pereira Cardenal, Silvio Javier; Carrion-Sanchez, Laura; Arnbjerg-Nielsen, Karsten

    2011-01-01

    ; and the demands from one system to the other are computed by both models jointly. For this purpose, we develop a bidding strategy for a price-taker hydropower generator based on reservoir volumes and expected electricity prices. The results from the methodology are comparable to those from a dynamic program...

  2. History of Electricity in Lesotho and The Place of 'Muela Hydropower ...

    African Journals Online (AJOL)

    This paper examines the history of electricity in Lesotho from the colonial time to the present within the broader framework of socio-economic development. Taking the 'Muela hydropower plant, the Lesotho Electricity Corporation and the Southern African Power Pool as illustration, the paper raises three related arguments.

  3. The Grossmatt hydro-power station

    International Nuclear Information System (INIS)

    Hintermann, M.

    2006-01-01

    This final report for the Swiss Federal Office of Energy (SFOE) presents the project for a small hydropower station on the Birs river in north-western Switzerland. The report reviews the history of the project, in which a new 385 kW-hydro-power station at the site of an earlier installation is foreseen. Details are presented on the investigations made and on the co-ordination with the owners of the hydro-power station situated up-river, the local power utility and the local authorities. Also, the requirements placed on the project by the fishing authorities are quoted and the solution foreseen is described. Also discussed are the requirements placed on the project by legislation on environmental impact and flood protection. Figures on electrical energy production and building costs are presented

  4. Resonance sensitivity of hydropower and pumping stations

    Energy Technology Data Exchange (ETDEWEB)

    Popescu, M.; Halanay, A.

    1984-09-01

    Comparative analysis of resonance diagrams for several hydropower and pumping stations with surge tanks and air chambers shows large differences in the maximum resonance pressures. A strategy is advocated which consists of hydraulic resonance computations coupled with practical surveillance measures during the operation of resonance sensitive hydraulic systems. A fundamental hydraulic scheme is considered consisting of a reservoir, a pressure tunnel, a surge tank, a penstock and a turbine combined into a hydropower station. It is suggested that for each hydraulic surge system it is necessary to carry out special resonance analyses following the normal procedure to obtain the resonance sensitivity. For hydraulic systems which are resonance sensitive, mechanical electronic equipment should be used to measure non-stationary pressures of the water in the conduit as a way of continuous surveillance during functioning. 6 references, 6 figures.

  5. Small hydropower station in Lavin - Preliminary study

    International Nuclear Information System (INIS)

    Merz, F.

    2008-05-01

    This illustrated final report for the Swiss Federal Office of Energy (SFOE) presents the results of a preliminary study regarding a proposed small hydropower installation on the alpine river Lavinuoz in Lavin, Switzerland. The geographical situation with mountains and glaciers in the catchment area of the proposed hydropower installation is discussed as are the appropriate water catchment installations. Possible dangers caused by avalanches and rock fall are examined. The power to be produced - 5,500,000 kWh/y - by the turbine which is nominally rated at 1350 kW is discussed, as are estimates of production costs. Figures on the investments required and the economic feasibility of the project are discussed, as are environmental factors that are to be taken into account.

  6. Steady and transient regimes in hydropower plants

    Science.gov (United States)

    Gajic, A.

    2013-12-01

    Hydropower plant that has been in operation for about 30 years has to be reconstructed. They have already installed 12 Kaplan turbines, the largest in the world at that time. The existing CAM relationship was determined based on hydraulic model tests and checked by efficiency on-site tests. It was also tested based on turbine bearing vibrations. In order to discover vibrations and long cracks on stay vanes detailed on-site measurements were performed. Influence of the modification of the trailing edges on the dynamic stresses of the stay vanes is also shown. In order to improve power output transient regimes were analyzed, both experimentally and numerically. Reversible hydropower plant, a pioneer in Europe since it was the first Pump storage power plant constructed with the highest head pump-turbines in the world. Analyses of transient regimes discover some problems with S-shaped characteristics coupled with non-symmetrical penstock.

  7. Steady and transient regimes in hydropower plants

    International Nuclear Information System (INIS)

    Gajic, A

    2013-01-01

    Hydropower plant that has been in operation for about 30 years has to be reconstructed. They have already installed 12 Kaplan turbines, the largest in the world at that time. The existing CAM relationship was determined based on hydraulic model tests and checked by efficiency on-site tests. It was also tested based on turbine bearing vibrations. In order to discover vibrations and long cracks on stay vanes detailed on-site measurements were performed. Influence of the modification of the trailing edges on the dynamic stresses of the stay vanes is also shown. In order to improve power output transient regimes were analyzed, both experimentally and numerically. Reversible hydropower plant, a pioneer in Europe since it was the first Pump storage power plant constructed with the highest head pump-turbines in the world. Analyses of transient regimes discover some problems with S-shaped characteristics coupled with non-symmetrical penstock

  8. Environmental certification for small hydropower plants

    International Nuclear Information System (INIS)

    Truffer, B.; Meier, W.; Vollenweider, S.; Seiler, B.; Dettli, R.

    2001-01-01

    This report for the Swiss Federal Institute for Environmental Science and Technology describes product-differentiation options for small hydropower plant in Switzerland and proposes a form of differentiation based on ecological characteristics as a promising market strategy. The labels created in various countries to assure customers of the environmental compatibility of 'green' power production are looked at. In particular, the implications for small hydropower plant associated with the Swiss green power labelling procedure introduced by the Association for the Promotion of Environmentally Sound Electricity (VUE) are discussed. The report proposes a simplified procedure for these small power stations and presents a sample calculation for the overall costs of certification. The report is rounded off with four detailed case studies in which the necessary upgrades to the plant and associated costs are discussed in detail

  9. Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Zhihong; Zhang, Yuxia [Departments of Medicine and Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 (United States); Wang, Li, E-mail: l.wang@hsc.utah.edu [Departments of Medicine and Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT 84132 (United States)

    2012-01-13

    Highlights: Black-Right-Pointing-Pointer Mdm2 enhances HNF4{alpha} activation of the ApoCIII promoter via interaction with HNF4{alpha}. Black-Right-Pointing-Pointer p53 antagonizes the effect of Mdm2 activation of the ApoCIII promoter. Black-Right-Pointing-Pointer SHP strengthens p53 inhibition but abolishes Mdm2 activation of the ApoCIII promoter. Black-Right-Pointing-Pointer Mdm2 alters the enrichment of HNF4{alpha}, p53 and SHP to the ApoCIII promoter. -- Abstract: We examined the effect of Mdm2 on regulation of the ApoCIII promoter and its cross-talk with p53 and nuclear receptor SHP. Overexpression of Mdm2 markedly enhanced ApoCIII promoter activity by HNF4{alpha}. A direct association of Mdm2 protein with the HNF4{alpha} protein was observed by co-immunoprecipitation. Ectopic expression of p53 decreased HNF4{alpha} activation of the ApoCIII promoter and antagonized the effect of Mdm2. Co-expression of SHP further strengthened p53 inhibition and abolished Mdm2 activation of the ApoCIII promoter. Mdm2 inhibited p53-mediated enrichment of HNF4{alpha} to the ApoCIII promoter while simultaneously reducing p53 binding and increasing recruitment of SHP to the ApoCIII promoter. The results from this study implicate a potentially important function of Mdm2 in regulation of lipoprotein metabolism.

  10. Mdm2 is a novel activator of ApoCIII promoter which is antagonized by p53 and SHP inhibition

    International Nuclear Information System (INIS)

    Yang, Zhihong; Zhang, Yuxia; Wang, Li

    2012-01-01

    Highlights: ► Mdm2 enhances HNF4α activation of the ApoCIII promoter via interaction with HNF4α. ► p53 antagonizes the effect of Mdm2 activation of the ApoCIII promoter. ► SHP strengthens p53 inhibition but abolishes Mdm2 activation of the ApoCIII promoter. ► Mdm2 alters the enrichment of HNF4α, p53 and SHP to the ApoCIII promoter. -- Abstract: We examined the effect of Mdm2 on regulation of the ApoCIII promoter and its cross-talk with p53 and nuclear receptor SHP. Overexpression of Mdm2 markedly enhanced ApoCIII promoter activity by HNF4α. A direct association of Mdm2 protein with the HNF4α protein was observed by co-immunoprecipitation. Ectopic expression of p53 decreased HNF4α activation of the ApoCIII promoter and antagonized the effect of Mdm2. Co-expression of SHP further strengthened p53 inhibition and abolished Mdm2 activation of the ApoCIII promoter. Mdm2 inhibited p53-mediated enrichment of HNF4α to the ApoCIII promoter while simultaneously reducing p53 binding and increasing recruitment of SHP to the ApoCIII promoter. The results from this study implicate a potentially important function of Mdm2 in regulation of lipoprotein metabolism.

  11. Hydropower in Turkey: potential and market assessment

    Energy Technology Data Exchange (ETDEWEB)

    2010-10-15

    The Turkish hydropower market provides huge opportunities for investors and suppliers. Successful market entry is not easy, however, as the market is still not fully liberalized, the need for local intelligence is large and the competition is increasing. There are also potential political, reputational and environmental risks, typical for an emerging economy. The World Bank global 'Ease of doing business' ranking (2010), ranks Turkey as number 73 of 183 countries. (Author)

  12. 77 FR 51551 - Proposed Renewal of Information Collection: Alternatives Process in Hydropower Licensing

    Science.gov (United States)

    2012-08-24

    ...: Alternatives Process in Hydropower Licensing AGENCY: Office of the Secretary, Office of Environmental Policy... approval for the collection of information for Alternatives Process in Hydropower Licensing. This... comments should reference Alternatives Process in Hydropower Licensing. FOR FURTHER INFORMATION CONTACT: To...

  13. 78 FR 69080 - Houtama Hydropower LLC; Notice of Preliminary Permit Application Accepted for Filing and...

    Science.gov (United States)

    2013-11-18

    ... Hydropower LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On August 14, 2013, Houtama Hydropower LLC filed an.... Hampton, CEO, Houtama Hydropower [[Page 69081

  14. Assessment of small hydropower potential by software. Case study

    Directory of Open Access Journals (Sweden)

    Moldoveanu Alexandru

    2017-01-01

    Full Text Available The rivers hydropower potential is considered one of the oldest renewable energy source used in the electricity production process. A method to investigate the possibility to construct a micro hydropower system on a small river is presented. The analysis and the hydropower assessment were done by using Vapidro-Aste software. Results point out that micro-hydro units can be implemented in remote locations or hybrid renewable energy systems, while the environmental flow is guaranteed.

  15. Water-quality impact assessment for hydropower

    International Nuclear Information System (INIS)

    Daniil, E.I.; Gulliver, J.; Thene, J.R.

    1991-01-01

    A methodology to assess the impact of a hydropower facility on downstream water quality is described. Negative impacts can result from the substitution of discharges aerated over a spillway with minimally aerated turbine discharges that are often withdrawn from lower reservoir levels, where dissolved oxygen (DO) is typically low. Three case studies illustrate the proposed method and problems that can be encountered. Historic data are used to establish the probability of low-dissolved-oxygen occurrences. Synoptic surveys, combined with downstream monitoring, give an overall picture of the water-quality dynamics in the river and the reservoir. Spillway aeration is determined through measurements and adjusted for temperature. Theoretical computations of selective withdrawal are sensitive to boundary conditions, such as the location of the outlet-relative to the reservoir bottom, but withdrawal from the different layers is estimated from measured upstream and downstream temperatures and dissolved-oxygen profiles. Based on field measurements, the downstream water quality under hydropower operation is predicted. Improving selective withdrawal characteristics or diverting part of the flow over the spillway provided cost-effective mitigation solutions for small hydropower facilities (less than 15 MW) because of the low capital investment required

  16. India's hydropower vision to 2030 - environmental issues

    International Nuclear Information System (INIS)

    Goel, R.S.

    2004-01-01

    The economic advantages of hydropower has been enhanced in the recent years with the steep increases in the energy costs from fossil fuel and the rapid approaching limits to the exploitable resources of such fuels. It is a matter of concern that the share of hydropower in the total installed capacity in India has been declining in successive plans. In the 1962-63, hydro projects had a 50% share in the total installed capacity which has declined to 24%. Such a dismal share of hydro thermal mix is adversely affecting the optimal utilisation of natural and financial resources besides resulting in failure of power grids. Even a layman can appreciate that in the situation of monsoonic weather the storage of river flows during floods is unavoidable not only to meet the basic needs of bulging population for diverse uses but also to moderate the floods, droughts and poverty. This article focuses on the environmental issues related to hydropower and river valley projects, while pinpointing the vital need of large storage projects in India. The water is becoming scarcer in India due to bulging population; but the environmental activism and biased media reporting are creating large scale obstructions in the execution of hydro projects

  17. World Small Hydropower Development Report 2013 - Lesotho

    CSIR Research Space (South Africa)

    Jonker Klunne, W

    2013-01-01

    Full Text Available . The designations employed and the presentations of the material in this document do not imply the expression of any opinion whatsoever on the part of the Secretariat of UNIDO and ICSHP concerning the legal status of any country, territory, city or area or of its... of these being in urban areas. 3 The Government has set a goal of increasing electrification rate to 35 per cent of total households by 2015 and 40 per cent by 2020. The Electricity Supply Industry in Lesotho is regulated by the Lesotho Electricity...

  18. World Small Hydropower Development Report 2013 - Swaziland

    CSIR Research Space (South Africa)

    Jonker Klunne, W

    2013-01-01

    Full Text Available Power in Swaziland is supplied and distributed by the Swaziland Electricity Company (SEC), which was established in 2007 by the Swaziland Electricity Company Act. SEC currently has a monopoly on the import, distribution and supply of electricity via...

  19. determination of head for small hydropower development

    African Journals Online (AJOL)

    eobe

    volumetric flow of 31.73 m3/s, the power potential of the River Ethiope was placed at 2.43 MW. It ca. /s, the power potential ... water projects such as water supply, irrigation and ..... f is the friction factor (unit-less), L is the length of the pipe (m), D ...

  20. Integrating multicriteria evaluation and stakeholders analysis for assessing hydropower projects

    International Nuclear Information System (INIS)

    Rosso, M.; Bottero, M.; Pomarico, S.; La Ferlita, S.; Comino, E.

    2014-01-01

    The use of hydroelectric potential and the protection of the river ecosystem are two contrasting aspects that arise in the management of the same resource, generating conflicts between different stakeholders. The purpose of the paper is to develop a multi-level decision-making tool, able to support energy planning, with specific reference to the construction of hydropower plants in mountain areas. Starting from a real-world problem concerning the basin of the Sesia Valley (Italy), an evaluation framework based on the combined use of Multicriteria Evaluation and Stakeholders Analysis is proposed in the study. The results of the work show that the methodology is able to grant participated decisions through a multi-stakeholders traceable and transparent assessment process, to highlight the important elements of the decision problem and to support the definition of future design guidelines. - Highlights: • The paper concerns a multi-level decision-making tool able to support energy planning. • The evaluation framework is based on the use of AHP and Stakeholders Analysis. • Hydropower projects in the Sesia Valley (Italy) are evaluated and ranked in the study. • Environmental, economic, technical and sociopolitical criteria have been considered. • 42 stakeholder groups have been included in the evaluation

  1. A progress report on DOE's advanced hydropower turbine systems program

    International Nuclear Information System (INIS)

    Sale, M.J.; Cada, G.F.; Rinehart, B.E.

    1997-01-01

    Recent hydropower research within the U.S. Department of Energy (DOE) has focused on the development of new turbine designs that can produce hydroelectricity without such adverse environmental affects as fish entrainment/impingement or degradation of water quality. In partnership with the hydropower industry, DOE's advanced turbine program issued a Request for Proposals for conceptual designs in October 1994. Two contracts were awarded for this initial program phase, work on which will be complete this year. A technical advisory committee with representatives from industry, regulatory agencies, and natural resource agencies was also formed to guide the DOE turbine research. The lack of quantitative biological performance criteria was identified by the committee as a critical knowledge gap. To fill this need, a new literature review was completed on the mechanisms of fish mortality during turbine passage (e.g., scrape/strike, shear, press change, etc.), ways that fish behavior affects their location and orientation in turbines, and how these turbine passage stresses can be measured. Thus year, new Laboratory tests will be conducted on fish response to shear, the least-well understood mechanism of stress. Additional testing of conceptual turbine designs depends on the level of federal funding for this program

  2. Wind-Driven Ecological Flow Regimes Downstream from Hydropower Dams

    Science.gov (United States)

    Kern, J.; Characklis, G. W.

    2012-12-01

    challenge, the following study was designed to investigate the potential for wind power integration to alter riparian flow regimes below hydroelectric dams. A hydrological model of a three-dam cascade in the Roanoke River basin (Virginia, USA) is interfaced with a simulated electricity market (i.e. a unit commitment problem) representing the Dominion Zone of PJM Interconnection. Incorporating forecasts of electricity demand, hydro capacity and wind availability, a mixed-integer optimization program minimizes the system cost of meeting hourly demand and reserve requirements by means of a diverse generation portfolio (e.g. nuclear, fossil, hydro, and biomass). A secondary 'balancing' energy market is executed if real-time wind generation is less than the day-ahead forecast, calling upon reserved generation resources to meet the supply shortfall. Hydropower release schedules are determined across a range of wind development scenarios (varying wind's fraction of total installed generating capacity, as well as its geographical source region). Flow regimes for each wind development scenario are compared against both historical and simulated flows under current operations (negligible wind power), as well as simulated natural flows (dam removal), in terms of ecologically relevant flow metrics. Results quantify the ability of wind power development to alter within-week stream flows downstream from hydropower dams.

  3. Protein tyrosine phosphatase SHP2/PTPN11 mistargeting as a consequence of SH2-domain point mutations associated with Noonan Syndrome and leukemia

    DEFF Research Database (Denmark)

    Müller, Pia J; Rigbolt, Kristoffer T G; Paterok, Dirk

    2013-01-01

    SHP2/PTPN11 is a key regulator of cytokine, growth factor and integrin signaling. SHP2 influences cell survival, proliferation and differentiation by regulating major signaling pathways. Mutations in PTPN11 cause severe diseases like Noonan, LEOPARD syndrome or leukemia. Whereas several...

  4. SHP-1 is directly activated by the aryl hydrocarbon receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)

    Energy Technology Data Exchange (ETDEWEB)

    Phadnis-Moghe, Ashwini S.; Li, Jinpeng [Genetics Program, Michigan State University, East Lansing, MI 48824 (United States); Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Crawford, Robert B. [Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Kaminski, Norbert E., E-mail: kamins11@msu.edu [Institute for Integrative Toxicology, Michigan State University, East Lansing, MI 48824 (United States); Department of Pharmacology and Toxicology, Michigan State University, East Lansing, MI 48824 (United States)

    2016-11-01

    The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a strong AHR agonist, causes significant suppression of human B cell activation and differentiation. The current studies describe the identification of Src homology phosphatase 1 (SHP-1) encoded by the gene PTPN6 as a putative regulator of TCDD-mediated suppression of B cell activation. Shp-1 was initially identified through a genome-wide analysis of AHR binding in mouse B cells in the presence of TCDD. The binding of AHR to the PTPN6 promoter was further confirmed using electrophoretic mobility shift assays in which, specific binding of AHR was detected at four putative DRE sites within PTPN6 promoter. Time-course measurements performed in human B cells highlighted a significant increase in SHP-1 mRNA and protein levels in the presence of TCDD. The changes in the protein levels of SHP-1 were also observed in a TCDD concentration-dependent manner. The increase in SHP-1 levels was also seen to occur due to a change in early signaling events in the presence of TCDD. We have shown that BCL-6 regulates B cell activation by repressing activation marker CD80 in the presence of TCDD. TCDD-treatment led to a significant increase in the double positive (SHP-1{sup hi} BCL-6{sup hi}) population. Interestingly, treatment of naïve human B cells with SHP-1 inhibitor decreased BCL-6 protein levels suggesting possible regulation of BCL-6 by SHP-1 for the first time. Collectively, these results suggest that SHP-1 is regulated by AHR in the presence of TCDD and may, in part through BCL-6, regulate TCDD-mediated suppression of human B cell activation. - Highlights: • SHP-1 encoded by the gene PTPN6 is directly activated by the AHR. • AHR binds to dioxin response elements within the SHP-1 promoter in a TCDD-inducible manner. • TCDD-mediated increase in SHP-1 levels is observed in primary human B cells. • Higher SHP-1 levels help in maintaining high BCL-6 levels in the presence of TCDD. • In

  5. Methylation profiling of SOCS1, SOCS2, SOCS3, CISH and SHP1 in Philadelphia-negative myeloproliferative neoplasm.

    Science.gov (United States)

    Zhang, Min Yue; Fung, Tsz Kin; Chen, Fang Yuan; Chim, Chor Sang

    2013-10-01

    Janus kinase-signal transducer and activator of transcription (JAK/STAT) signalling, pivotal in Philadelphia-negative (Ph-ve) myeloproliferative neoplasm (MPN), is negatively regulated by molecules including SOCSs, CISH and SHP1. SOCS1, SOCS2 and SOCS3 methylation have been studied in MPN with discordant results. Herein, we studied the methylation status of SOCS1, SOCS2 and SOCS3, CISH and SHP1 by methylation-specific polymerase chain reaction (MSP) in cell lines and 45 diagnostic marrow samples of Ph-ve MPN. Moreover, we attempted to explain the discordance of methylation frequency by mapping the studied MSP primers to the respective genes. Methylation was detected in normal controls using SOCS2 MSP primers in the 3'translated exonic sequence, but not primers around the transcription start site in the 5' untranslated regions (5'UTR). SOCS1, SOCS2, SOCS3 and CISH were completely unmethylated in primary MPN samples and cell lines. In contrast, methylation of SHP1 was detected in 8.9% primary marrow samples. Moreover, SHP1 was completely methylated in K562 cell line, leading to reversible SHP1 silencing. A review of methylation studies of SOCS1 and SOCS3 showed that spuriously high rates of SOCS methylation had been reported using MSP primers targeting CpG sites in the 3'translated exonic sequence, which is also methylated in normal controls. However, using MSP primers localized to the 5'UTR, methylation of SOCS1, SOCS2 and SOCS3 is infrequent across all studies. In summary, methylation of SOCS1, SOCS2, SOCS3 and CISH is infrequent in Ph-ve MPN. Appropriate MSP primers are important for accurate estimation of the methylation frequency. The role of SHP1 methylation in the pathogenesis of MPN warrants further investigation. © 2013 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine.

  6. A Highly Stable Porphyrinic Zirconium Metal–Organic Framework with shp-a Topology

    Energy Technology Data Exchange (ETDEWEB)

    Feng, Dawei; Gu, Zhi-Yuan; Chen, Ying-Pin; Park, Jihye; Wei, Zhangwen; Sun, Yujia; Bosch, Mathieu; Yuan, Shuai; Zhou, Hong-Cai

    2014-12-24

    Through a kinetically controlled synthetic process, we synthesized PCN-223, a new porphyrinic Zr-MOF constructed from the newly reported hexagonal prismatic 12-connected Zr6 cluster through an unusual disordered arrangement, giving rise to the first example of the shp-a network in MOFs. With its extremely high connectivity, PCN-223 shows high stability in aqueous solutions with a wide range of pH. Cationic PCN-223(Fe) formed by postsynthetic treatment is an excellent recyclable heterogeneous catalyst for the hetero-Diels–Alder reaction.

  7. Along-the-net reconstruction of hydropower potential with consideration of anthropic alterations

    Directory of Open Access Journals (Sweden)

    A. Masoero

    2014-09-01

    Full Text Available Even in regions with mature hydropower development, requirements for stable renewable power sources suggest revision of plans of exploitation of water resources, while taking care of the environmental regulations. Mean Annual Flow (MAF is a key parameter when trying to represent water availability for hydropower purposes. MAF is usually determined in ungauged basins by means of regional statistical analysis. For this study a regional estimation method consistent along-the-river network has been developed for MAF estimation; the method uses a multi-regressive approach based on geomorphoclimatic descriptors, and it is applied on 100 gauged basins located in NW Italy. The method has been designed to keep the estimates of mean annual flow congruent at the confluences, by considering only raster-summable explanatory variables. Also, the influence of human alterations in the regional analysis of MAF has been studied: impact due to the presence of existing hydropower plants has been taken into account, restoring the "natural" value of runoff through analytical corrections. To exemplify the representation of the assessment of residual hydropower potential, the model has been applied extensively to two specific mountain watersheds by mapping the estimated mean flow for the basins draining into each pixel of a the DEM-derived river network. Spatial algorithms were developed using the OpenSource Software GRASS GIS and PostgreSQL/PostGIS. Spatial representation of the hydropower potential was obtained using different mean flow vs hydraulic-head relations for each pixel. Final potential indices have been represented and mapped through the Google Earth platform, providing a complete and interactive picture of the available potential, useful for planning and regulation purposes.

  8. Climate impacts on hydropower and consequences for global electricity supply investment needs

    Energy Technology Data Exchange (ETDEWEB)

    Turner, Sean W. D.; Hejazi, Mohamad; Kim, Son H.; Clarke, Leon; Edmonds, Jae

    2017-12-01

    Recent progress in global scale hydrological and dam modeling has allowed for the study of climate change impacts on global hydropower production. Here we explore the possible consequences of these impacts for the electricity supply sector. Regional hydropower projections are developed for two emissions scenarios by forcing a coupled global hydrological and dam model with downscaled, bias-corrected climate realizations derived from sixteen general circulation models. Consequent impacts on power sector composition and associated emissions and investment costs are explored using the Global Change Assessment Model (GCAM). Changes in hydropower generation resulting from climate change can shift power demands onto and away from carbon intensive technologies, resulting in significant impacts on power sector CO2 emissions for certain world regions—primarily those located in Latin America, as well as Canada and parts of Europe. Reduced impacts of climate change on hydropower production under a low emissions scenario coincide with increased costs of marginal power generating capacity—meaning impacts on power sector investment costs are similar for high and low emissions scenarios. Individual countries where impacts on investment costs imply significant risks or opportunities are identified.

  9. National hydroelectric power resources study. Preliminary inventory of hydropower resources. Volume 1. Pacific Northwest region

    Energy Technology Data Exchange (ETDEWEB)

    None

    1979-07-01

    The preliminary inventory and analysis procedures provide a comprehensive assessment of the undeveloped hydroelectric power potential in the US and determines which sites merit more thorough investigation. Over 5400 existing structures have been identified as having the physical potential to add hydropower plants or increase hydropower output thereby increasing our present hydropower capacity from a total of 64,000 MW to 158,000 MW and our energy from 280,000 GWH to 503,000 GWH. While the physical potential for this increase is clearly available, some of these projects will undoubtedly not satisfy more-detailed economic analysis as well as the institutional and environmental criteria which will be imposed upon them. Summary tables include estimates of the potential capacity and energy at each site in the inventory. In some cases, individual projects may be site alternatives to others in the same general location, when only one can be considered for hydropower development. The number of sites per state is identified, but specific information is included for only the sites in Alaska, Idaho, Oregon, and Washington in this first volume.

  10. Sustainable Effects of Small Hydropower Substituting Firewood Program in Majiang County, Guizhou Province, China

    Directory of Open Access Journals (Sweden)

    Xiaoxia Zhang

    2017-06-01

    Full Text Available Small hydropower substituting fuel (SHSF is an ecological environment protection program to improve regional ecosystems and alleviate poverty. However, the sustainability of SHSF programs remains controversial due to lingering doubts about its potential for socioeconomic development and its environmental impacts. The sustainability of SHSF was examined based on field investigations and household questionnaire surveys. The results were as follows: (1 Biomass of SHSF protected masson pine (Pinus massoniana and weeping cypress (Platycladus orientalis plantations were 11.06 t·ha−1 and 7.15 t·ha−1 higher than unprotected plantations, respectively. Furthermore, the differences in ecosystem biomass were mainly derived from arbor biomass. While the energy conversion efficiency based on field investigations was merely 1.28 kg (kWh−1, which was only 64% of the empirical value and 54% of the guideline for accounting for the ecological benefit of small hydropower substituting fuel. (2 Households’ total income in SHSF villages was higher than in households with access to a hydropower plant but no substituting fuel or households with no hydropower plant. (3 Most of the households had a positive attitude towards SHSF because of its cheaper electricity and associated ecological environmental improvements. Overall, our results suggest optimistic and sustainable prospects for the SHSF program; however, continued education and policy communications are needed to sustain program success.

  11. Ecohydrological Design of small hydropower plants: assessment of environmental flows

    International Nuclear Information System (INIS)

    Diez H, Juan M; Olmeda S, Sergio

    2008-01-01

    The small hydroelectric energy has contributed substantially to the progress of the life standards in the world by means of a technology with a relatively low environmental impact. The Small Hydroelectric Plant (SHP) is the convenient type of hydro energetic facility for Colombia, reason why it predictably will play a capital role in the exploitation of its excellent potential during this decade. The regulatory guidelines for the SHP re licensing enforce hydrological design criteria that incorporate the ecological requirements of discharge in the fluvial reaches affected by flow derivations. The Instream Flow (IF) should be considered as an ecological restriction to the hydroelectric use, which can be satisfactorily set with reliable approaches. This work shows the basic typology of IF assessment methods, describing the reputed Instream Flow Incremental Methodology (IFIM) with a case study of SHP re licensing. It also demonstrates the possibility of harmonize the hydroelectric operation with the maintenance of an acceptable ecological condition, preserving some IF that can be assessed with the IFIM analytic frame. The new eco hydrological methods for IF setting facilitate SHP that are profitable and defensible in environmental terms.

  12. Tapping hidden hydropower potential in Swiss Alpine catchments in the context of the planned nuclear power phase out

    Science.gov (United States)

    Santos, Ana Clara; Schaefli, Bettina; Manso, Pedro; Schleiss, Anton; Portela, Maria Manuela; Rinaldo, Andrea

    2015-04-01

    In its Energy Strategy 2050, Switzerland is revising its energy perspectives with a strong focus on renewable sources of energy and in particular hydropower. In this context, the Swiss Government funded a number of competence centers for energy research (SCCERs), including one on the Supply of Energy (SCCER-SoE), which develops fundamental research and innovative solutions in geoenergies and hydropower . Hydropower is already the major energy source in Switzerland, corresponding to approximately 55% of the total national electricity production (which was 69 TWh in 2014). The Energy Strategy 2050 foresees at least a net increase by 1.53 TWh/year in average hydrological conditions, in a context were almost all major river systems are already exploited and a straightforward application of recent environmental laws will impact (reduce) current hydropower production. In this contribution, we present the roadmap of the SCCER-SoE and an overview of our strategy to unravel currently non-exploited hydropower potential, in particular in river systems that are already used for hydropower production. The aim is hereby to quantify non-exploited natural flows, unnecessary water spills or storage volume deficits, whilst considering non-conventional approaches to water resources valuation and management. Such a better understanding of the current potential is paramount to justify future scenarios of adaptation of the existing hydropower infrastructure combining the increase of storage capacity with new connections between existing reservoirs, heightening or strengthening existing dams, increasing the operational volume of natural lakes (including new glacier lakes), or by building new dams. Tapping hidden potential shall also require operational changes to benefit from new flow patterns emerging under an evolving climate and in particular in the context of the ongoing glacier retreat. The paper shall present a broad view over the mentioned issues and first conclusions of ongoing

  13. 77 FR 2286 - Northern Illinois Hydropower, LLC; Notice of Meeting

    Science.gov (United States)

    2012-01-17

    ... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Project No. 12717-002] Northern Illinois Hydropower, LLC; Notice of Meeting a. Date and Time of Meeting: Thursday, January 26, 2012 from 11... Meeting: Commission staff will meet with Northern Illinois Hydropower, LLC to discuss potentially moving...

  14. The Second Assessment of the Effects of Climate Change on Federal Hydropower

    Energy Technology Data Exchange (ETDEWEB)

    Kao, Shih-Chieh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Ashfaq, Moetasim [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Naz, Bibi S. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Uria Martinez, Rocio [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rastogi, Deeksha [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Mei, Rui [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Jager, Yetta [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Samu, Nicole M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Sale, Michael J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-09-01

    Hydropower is a key contributor to the US renewable energy portfolio due to its established development history and the diverse benefits it provides to the electric power system. Ensuring the sustainable operation of existing hydropower facilities is of great importance to the US renewable energy portfolio and the reliability of electricity grid. As directed by Congress in Section 9505 of the SECURE Water Act (SWA) of 2009 (Public Law 111-11), the US Department of Energy (DOE), in consultation with the federal Power Marketing Administrations (PMAs) and other federal agencies, has prepared a second quinquennial report on examining the potential effects of climate change on water available for hydropower at federal facilities and on the marketing of power from these federal facilities. This Oak Ridge National Laboratory (ORNL) Technical Memorandum, referred to as the 9505 assessment, describes the technical basis for the report to Congress that was called for in the SWA. To evaluate the potential climate change effects on 132 federal hydropower plants across the entire US, a spatially consistent assessment approach is designed to enable an interregional comparison. This assessment uses a series of models and methods with different spatial resolutions to gradually downscale the global climate change signals into watershed-scale hydrologic projections to support hydropower impact assessment. A variety of historic meteorological and hydrologic observations, hydropower facility characteristics, and geospatial datasets is collected to support model development, calibration, and verification. Among most of the federal hydropower plants throughout the US, the most important climate change effect on hydrology is likely to be the trend toward earlier snowmelt and change of runoff seasonality. Under the projections of increasing winter/spring runoff and decreasing summer/fall runoff, water resource managers may need to consider different water use allocations. With the

  15. Optimal Operation of Hydropower Reservoirs under Climate Change: The Case of Tekeze Reservoir, Eastern Nile

    Directory of Open Access Journals (Sweden)

    Fikru Fentaw Abera

    2018-03-01

    Full Text Available Optimal operation of reservoirs is very essential for water resource planning and management, but it is very challenging and complicated when dealing with climate change impacts. The objective of this paper was to assess existing and future hydropower operation at the Tekeze reservoir in the face of climate change. In this study, a calibrated and validated Soil and Water Assessment Tool (SWAT was used to model runoff inflow into the Tekeze hydropower reservoir under present and future climate scenarios. Inflow to the reservoir was simulated using hydro-climatic data from an ensemble of downscaled climate data based on the Coordinated Regional climate Downscaling Experiment over African domain (CORDEX-Africa with Coupled Intercomparison Project Phase 5 (CMIP5 simulations under Representative Concentration Pathway (RCP4.5 and RCP8.5 climate scenarios. Observed and projected inflows to Tekeze hydropower reservoir were used as input to the US Army Corps of Engineer’s Reservoir Evaluation System Perspective Reservoir Model (HEC-ResPRM, a reservoir operation model, to optimize hydropower reservoir release, storage and pool level. Results indicated that climate change has a clear impact on reservoir inflow and showed increase in annual and monthly inflow into the reservoir except in dry months from May to June under RCP4.5 and RCP8.5 climate scenarios. HEC-ResPRM optimal operation results showed an increase in Tekeze reservoir power storage potential up to 25% and 30% under RCP4.5 and RCP8.5 climate scenarios, respectively. This implies that Tekeze hydropower production will be affected by climate change. This analysis can be used by water resources planners and mangers to develop reservoir operation techniques considering climate change impact to increase power production.

  16. Impact of glacier shrinkage and adapted hydropower potential in the Swiss Alps

    International Nuclear Information System (INIS)

    Terrier, Stephane; Bieri, Martin; Jordan, Frederic; Schleiss, Anton J.

    2015-01-01

    Global warming is an alarming reality and likely leads to an increase of multiple pressures on socio-economic systems. However, in high-mountain regions it might also become an opportunity to adapt existing hydropower schemes and to develop new projects to this reality. In the Alps, the melting of glaciers first produces over the near future an increase of the average annual discharge depending on glacier and catchment characteristics, especially during the summer season. Nevertheless after a certain time, significant decrease of runoff related to glacier melting must be considered for hydropower management. Moreover, the shrinking glaciers free new areas, having the potential for the construction of new dams and reservoirs. The opportunity to build new dams and hydropower plants downstream of retreating glaciers is studied using two models. The first (GlabTop) is used to predict the future topography and geomorphology underneath the melting glaciers, in order to define the optimal locations of the future dams and reservoirs. Secondly, the RS3.0 CLIMATE rainfall-runoff hydrological model computes the glacier evolution, the river discharge at the outlet of the catchment area as well as the hydropower production of the new schemes. As a case study the Upper Aare River basin in Switzerland is presented. The opportunity of the construction of a new dam and a hydropower plant is studied, including its economic benefit. The result of the case study provides a basis to assess the potential of investing in such projects to ensure the Swiss hydroelectricity production also in future as well as peak energy for the European grid. (authors)

  17. Critical evaluation of the hydropower applications in Greece

    Energy Technology Data Exchange (ETDEWEB)

    Kaldellis, J.K. [Laboratory of Soft Energy Applications and Environmental Protection, TEI Piraeus, P.O. Box 41046, Athens 12201 (Greece)

    2008-01-15

    Hydropower is a proven technology for electricity generation, contributing with almost 20% to the fulfilment of the planet electricity demand. Hydropower is also renewable because it draws its essential energy from the sun and particularly from the hydrological cycle. Greece and more precisely the west and north part of the mainland possesses significant hydropower potential that is up to now partially exploited. In the present survey, one investigates the existing situation concerning the applications of hydropower plants in Greece, while the results obtained are compared with the corresponding international and European situation. Subsequently, emphasis is laid on estimating the electricity-generation utilization degree of the existing large hydropower stations, using 25-year long official data. The results obtained underline the fact that the electricity generation is not a priority for the national water management policy and most Greek hydropower stations are used mainly to meet the corresponding peak load demand. On the other hand, increased interest to create numerous new small hydropower plants throughout Greece has been expressed during the last 5 years. According to the information gathered and analyzed, one may state that the available local hydropower potential is quite promising and can substantially contribute to the accomplishment of the national-EU target to cover the 21% of the corresponding electricity consumption from renewable resources. For this purpose one should first define an approved and rational water resources management plan and secondly support the increased utilization of large and small hydropower plants for electricity generation. In this case, properly designed hydropower plants should lead to considerable profits, contributing also in the country's independency from imported oil and accomplishing the Kyoto protocol obligations. (author)

  18. A model of the environmental impacts of hydropower projects

    International Nuclear Information System (INIS)

    Kemppainen, T.; Haemaelaeinen, I.

    1992-01-01

    The aim was to create a model of the effects of hydropower modernization and extension projects in Finland. To illustrate the effects of hydropower projects a checklist in the form of matrice was constructed. In this matrice all issues that could be significant in future hydropower projects were collected. Stable physical environmental changes are the starting-point for this matrice. The temporary change of hydropower constructions have also been under consideration. These are mainly environmental changes during construction. In chapter two the effects of hydropower modernization and extension projects physical environmental changes were examined. In chapter three the matrice was applied to some example cases. The cases were chosen to represent future hydropower projects. In addition these example cases represent urban areas, rural areas and uninhabited areas. The example cases were the extension of Tainionkoski hydropower plant at Vuoksi river, the modernization of Aeetsae power plant at Kokemaeenjoki river, the modernization of Stadsfors power plant at Lapuanjoki river in the centre of Uusikaarlepyy town and the construction of Kaitfors power plant at Perhonjoki river. Conclusions from usability of the model can be drawn on the ground of the example cases. The purpose of the model is to produce a checklist of estimated environmental effects in hydropower project of various kinds. Examination of issues within the model depends on local circumstances. Endangered animal and plant species, for example, can be studied and estimated only if endangered animal and plant species exist in the area of hydropower plant. Furthermore, the direction and extent of environmental effects depend on the local circumstances. The model is mainly a checklist of environmental effects caused by hydropower plant projects

  19. Impact of Different Time Series Streamflow Data on Energy Generation of a Run-of-River Hydropower Plant

    Science.gov (United States)

    Kentel, E.; Cetinkaya, M. A.

    2013-12-01

    Global issues such as population increase, power supply crises, oil prices, social and environmental concerns have been forcing countries to search for alternative energy sources such as renewable energy to satisfy the sustainable development goals. Hydropower is the most common form of renewable energy in the world. Hydropower does not require any fuel, produces relatively less pollution and waste and it is a reliable energy source with relatively low operating cost. In order to estimate the average annual energy production of a hydropower plant, sufficient and dependable streamflow data is required. The goal of this study is to investigate impact of streamflow data on annual energy generation of Balkusan HEPP which is a small run-of-river hydropower plant at Karaman, Turkey. Two different stream gaging stations are located in the vicinity of Balkusan HEPP and these two stations have different observation periods: one from 1986 to 2004 and the other from 2000 to 2009. These two observation periods show different climatic characteristics. Thus, annual energy estimations based on data from these two different stations differ considerably. Additionally, neither of these stations is located at the power plant axis, thus streamflow observations from these two stream gaging stations need to be transferred to the plant axis. This requirement introduces further errors into energy estimations. Impact of different streamflow data and transfer of streamflow observations to plant axis on annual energy generation of a small hydropower plant is investigated in this study.

  20. A preliminary evaluation of environmental indexes of great hydropower plants localized in various Brazilian states and geographical aspects

    International Nuclear Information System (INIS)

    Caetano de Souza, Antonio Carlos

    2009-01-01

    The predominantly tropical climate and the predominance of plateaus in Brazil contributed to the development of a high hydroelectric potential, which determined the choice of hydropower plants as main technology of electricity generation. Though this is a renewable source, dams must being established to guarantee high amount of water all over the year generating high environmental and social impact. One of the ways to evaluate environmental impacts caused by large hydropower plants is adoption of environmental indexes which are formed by ratio of installed or firm power with dam area of a hydropower plant. The objective of this study is to evaluate the impact caused by these dams through the use of environmental indexes. Statistical instruments were utilized to evaluate environmental indexes in the five Brazilian regions, twenty six states, and fifteen main rivers (where at least three large hydropower plants are encountered). The periods when each hydropower plant operation was initiated were also considered. In this study, the greatest media values were found in South, Southeast, and Northeast regions respectively, and the smallest media values were found in North and Mid-West regions, respectively. More, the greatest encountered media indexes were also found in dams established in the 1950s. (author)

  1. A light left in the dark: The practice and politics of pico-hydropower in the Lao PDR

    International Nuclear Information System (INIS)

    Smits, Mattijs; Bush, Simon R.

    2010-01-01

    The article describes the widespread use of an estimated 60,000 low-head pico-hydropower turbines and well-developed networks of supply and support in the Northern part of the Lao People's Democratic Republic (Lao PDR). This apparent widespread use is contrasted with the policy narratives of key actors in the government, multilateral organisations and the private sector which show an often simplified and overly negative attitude towards pico-hydropower. Based on empirical research carried out in three upland districts and the capital, Vientiane, the paper critically investigates the apparent disjuncture between policy and practice by placing pico-hydropower within the broader political context of rural electrification in the Lao PDR. It is argued that the neglect of pico-hydropower and other off-grid household electrification technologies is a result of an endemic lack of information on which to base policy decisions, the orientation of the government to facilitate large scale foreign investment in large hydropower dams, the universal applicability of solar home systems, and the broader state agenda of centralisation and control over service provision to remote upland areas.

  2. AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle.

    Science.gov (United States)

    Kim, Young-Chae; Seok, Sunmi; Byun, Sangwon; Kong, Bo; Zhang, Yang; Guo, Grace; Xie, Wen; Ma, Jian; Kemper, Byron; Kemper, Jongsook Kim

    2018-02-07

    Phosphatidylcholines (PC) and S-adenosylmethionine (SAM) are critical determinants of hepatic lipid levels, but how their levels are regulated is unclear. Here, we show that Pemt and Gnmt, key one-carbon cycle genes regulating PC/SAM levels, are downregulated after feeding, leading to decreased PC and increased SAM levels, but these effects are blunted in small heterodimer partner (SHP)-null or FGF15-null mice. Further, aryl hydrocarbon receptor (AhR) is translocated into the nucleus by insulin/PKB signaling in the early fed state and induces Pemt and Gnmt expression. This induction is blocked by FGF15 signaling-activated SHP in the late fed state. Adenoviral-mediated expression of AhR in obese mice increases PC levels and exacerbates steatosis, effects that are blunted by SHP co-expression or Pemt downregulation. PEMT, AHR, and PC levels are elevated in simple steatosis patients, but PC levels are robustly reduced in steatohepatitis-fibrosis patients. This study identifies AhR and SHP as new physiological regulators of PC/SAM levels.

  3. Phosphoproteomics-mediated identification of Fer kinase as a target of mutant Shp2 in Noonan and LEOPARD syndrome

    NARCIS (Netherlands)

    Paardekooper Overman, Jeroen; Preisinger, Christian; Prummel, Karin; Bonetti, Monica; Giansanti, Piero; Heck, Albert; den Hertog, Jeroen

    2014-01-01

    Noonan syndrome (NS) and LEOPARD syndrome (LS) cause congenital afflictions such as short stature, hypertelorism and heart defects. More than 50% of NS and almost all of LS cases are caused by activating and inactivating mutations of the phosphatase Shp2, respectively. How these biochemically

  4. Loss of SHP-1 tyrosine phosphatase expression correlates with the advanced stages of cutaneous T-cell lymphoma

    DEFF Research Database (Denmark)

    Witkiewicz, Agnieszka; Raghunath, Puthiyaveettil; Wasik, Agnieszka

    2007-01-01

    Cutaneous T-cell lymphoma (CTCL) comprises distinct and often progressive stages of skin involvement by patches, plaques, and tumors. We have previously demonstrated that CTCL-derived malignant T-cell lines display loss of a tumor suppressor SHP-1 tyrosine phosphatase because of epigenetic...

  5. Initiatives in the Hydro Sector Post-World Commission on Dams – The Hydropower Sustainability Assessment Forum

    Directory of Open Access Journals (Sweden)

    Helen Locher

    2010-06-01

    Full Text Available The World Commission on Dams (WCD has called for developers, governments, civil society, etc. to use its Strategic Priorities as a starting point for dialogue and initiatives to address issues regarding the development of dams. One very notable follow-up initiative has been led by the hydropower industry. The International Hydropower Association developed Sustainability Guidelines (IHA, 2004 and a Sustainability Assessment Protocol (IHA, 2006, and most recently has been involved in a two-year process with governments, NGOs and the finance sector to develop a broadly endorsed sustainability assessment tool based on review and update of the IHA Sustainability Assessment Protocol. This cross-sectoral process, known as the Hydropower Sustainability Assessment Forum (HSAF, has drawn on the knowledge base and many of the findings and recommendations of the World Commission on Dams, as well as a number of other developments in the last ten years. A fundamental premise of the work of the Forum is that an industry-driven and -owned initiative has far-reaching potential to influence performance in the hydropower sector. At the same time, the potential for the use of a broadly endorsed sustainability assessment tool for hydropower by those in other sectors is well recognised and aspired to by the Forum. This paper describes the work of the Forum up to August 2009 and the contents of the Draft Protocol released publicly in August 2009, and considers some of the commonalities and points of departure between this process and the WCD. The Forum’s work on the Hydropower Sustainability Assessment Protocol is a work in progress, so this paper can describe but not give a full analysis of the work while it is in train.

  6. 75 FR 65620 - Inglis Hydropower, LLC; Notice of Application Ready for Environmental Analysis and Soliciting...

    Science.gov (United States)

    2010-10-26

    ... Hydropower, LLC; Notice of Application Ready for Environmental Analysis and Soliciting Comments...: Inglis Hydropower, LLC. e. Name of Project: Inglis Hydropower Project. f. Location: The project would be... ready for environmental analysis at this time. l. The proposed 2.0-megawatt Inglis Hydropower Project...

  7. Problems of the climate and environment protection complicate the use of hydropower; Klimaproblematik und Umweltschutz erschweren Wasserkraftnutzung. Stromerzeugung in Suedtirol

    Energy Technology Data Exchange (ETDEWEB)

    Berger, W. [Orizzonti, Verona (Italy)

    2008-01-07

    Since the year 2000 warming and dryness have led to a strong reduction of electricity production from hydropower in Southern Tyrol. However, due to the attractive ''Green Certificates''-Scheme, there is still a strong interest in further developing hydropower activities. Such pressing must find its limits in nature conservation, particularly important for Southern Tyrol as a tourist area. The design of a detailed Water Use Plan of the Autonomous Province of Bolzano pleads clearly for restriction regarding the construction of new plants. This signals an opportunity for Southern Tyrol to further explore the development of its new renewable energy sources. (orig.)

  8. Optimal Management of Hydropower Systems

    Science.gov (United States)

    Bensalem, A.; Cherif, F.; Bennagoune, S.; Benbouza, M. S.; El-Maouhab, A.

    In this study we propose a new model for solving the short term management of water reservoirs with variable waterfall. The stored water in these reservoirs is used to produce the electrical energy. The proposed model is based on the enhancement of the value of water by taking into account its location in any reservoir and its waterfall high. The water outflow in the upper reservoir to produce electrical energy is reused in the lower reservoirs to produce electrical energy too. On the other hand the amount of water flow necessary to produce the same amount of electrical energy decrease as the high of waterfall increases. Thus, the objective function is represented in function of the water potential energy stocked in all reservoirs. To analyze this model, we have developed an algorithm based on the discrete maximum principle. To solve the obtained equations, an iterative method based on the gradient method is used. And to satisfy the constraints we have used the Augmented Lagrangian method.

  9. Project SHARE Sustainable Hydropower in Alpine Rivers Ecosystems

    Science.gov (United States)

    Mammoliti Mochet, Andrea

    2010-05-01

    SHARE - Sustainable Hydropower in Alpine Rivers Ecosystems is a running project early approved and co funded by the European regional development fund in the context of the European Territorial Cooperation Alpine Space programme 2007 - 2013: the project is formally ongoing from August 2009 and it will end July 2012. Hydropower is the most important renewable resource for electricity production in alpine areas: it has advantages for the global CO2 balance but creates serious environmental impacts. RES-e Directives require renewable electricity enhance but, at the same time, the Water Framework Directive obliges member States to reach or maintain a water bodies "good" ecological status, intrinsically limiting the hydropower exploitation. Administrators daily face an increasing demand of water abstraction but lack reliable tools to rigorously evaluate their effects on mountain rivers and the social and economical outputs on longer time scale. The project intends to develop, test and promote a decision support system to merge on an unprejudiced base, river ecosystems and hydropower requirements. This approach will be led using existing scientific tools, adjustable to transnational, national and local normative and carried on by permanent panel of administrators and stakeholders. Scientific knowledge related to HP & river management will be "translated" by the communication tools and spent as a concrete added value to build a decision support system. In particular, the Multicriteria Analysis (MCA) will be applied to assess different management alternatives where a single-criterion approach (such as cost-benefit analysis) falls short, especially where environmental, technical, economic and social criteria can't be quantified by monetary values. All the existing monitoring databases will be used and harmonized with new information collected during the Pilot case studies. At the same time, all information collected will be available to end users and actors of related

  10. Water Power: The “Hydropower Discourse” of China in an Age of Environmental Sustainability

    Directory of Open Access Journals (Sweden)

    Yuen-ching Bellette Lee

    2014-02-01

    Full Text Available As the world searches for renewable energy in the face of climate change and China attempts to expand its power supply to further its economic development, hydroelectricity has moved to the top of the country’s energy agenda. This has given rise to a new form of  “hydropower discourse” in China. The discourse is underpinned by the ideas of environmental protection and sustainable development, which are widely perceived as unobjectionable in view of the current availability of resources. This article argues that the apparent ethical pursuit of renewable energy by building dams to generate electricity masks relations of dominance and helps to enable large energy companies, political leaders, and regional decision makers to pursue their interests against those who have limited or no access to the knowledge and capital employed in the development process. It will examine the ideological assumptions and institutional rootedness of hydropower discourse, and the power relations embedded in it.

  11. Optimizing Wind And Hydropower Generation Within Realistic Reservoir Operating Policy

    Science.gov (United States)

    Magee, T. M.; Clement, M. A.; Zagona, E. A.

    2012-12-01

    Previous studies have evaluated the benefits of utilizing the flexibility of hydropower systems to balance the variability and uncertainty of wind generation. However, previous hydropower and wind coordination studies have simplified non-power constraints on reservoir systems. For example, some studies have only included hydropower constraints on minimum and maximum storage volumes and minimum and maximum plant discharges. The methodology presented here utilizes the pre-emptive linear goal programming optimization solver in RiverWare to model hydropower operations with a set of prioritized policy constraints and objectives based on realistic policies that govern the operation of actual hydropower systems, including licensing constraints, environmental constraints, water management and power objectives. This approach accounts for the fact that not all policy constraints are of equal importance. For example target environmental flow levels may not be satisfied if it would require violating license minimum or maximum storages (pool elevations), but environmental flow constraints will be satisfied before optimizing power generation. Additionally, this work not only models the economic value of energy from the combined hydropower and wind system, it also captures the economic value of ancillary services provided by the hydropower resources. It is recognized that the increased variability and uncertainty inherent with increased wind penetration levels requires an increase in ancillary services. In regions with liberalized markets for ancillary services, a significant portion of hydropower revenue can result from providing ancillary services. Thus, ancillary services should be accounted for when determining the total value of a hydropower system integrated with wind generation. This research shows that the end value of integrated hydropower and wind generation is dependent on a number of factors that can vary by location. Wind factors include wind penetration level

  12. Loss of European silver eel passing a hydropower station

    DEFF Research Database (Denmark)

    Pedersen, Michael Ingemann; Jepsen, Niels; Aarestrup, Kim

    2012-01-01

    The aim of this study was to assess escapement success of silver eels, Anguilla anguilla (L.), in a lowland river while passing a reservoir and a hydropower station. It was hypothesized that passage success would be lowest at the hydropower station and that survival and migration speed would...... that within the study period, only 23% of the tagged eels reached the tidal limit, mainly due to difficulties in passing the hydropower dam. With such high loss-rates, the escapement goals set in the management plan cannot be achieved...

  13. Mid and long-term optimize scheduling of cascade hydro-power stations based on modified GA-POA method

    Directory of Open Access Journals (Sweden)

    J. Li

    2018-06-01

    Full Text Available In this paper, to explore the efficiency and rationality of the cascade combined generation, a cascade combined optimal model with the maximum generating capacity is established, and solving the model by the modified GA-POA method. It provides a useful reference for the joint development of cascade hydro-power stations in large river basins. The typical annual runoff data are selected to calculate the difference between the calculated results under different representative years. The results show that the cascade operation of cascaded hydro-power stations can significantly increase the overall power generation of cascade and ease the flood risk caused by concentration of flood season.

  14. Climate Vulnerability of Hydro-power infrastructure in the Eastern African Power Pool

    Science.gov (United States)

    Sridharan, Vignesh

    2017-04-01

    At present there is around 6000 MW of installed hydropower capacity in the Eastern African power pool (EAPP)[1]. With countries aggressively planning to achieve the Sustainable development goal (SDG) of ensuring access to affordable electricity for all, a three-fold increase in hydropower capacity is expected by 2040 [1]. Most of the existing and planned infrastructure lie inside the Nile River Basin. The latest assessment report (AR 5) from the Intergovernmental Panel on Climate Change (IPCC) indicates a high level of climatic uncertainty in the Nile Basin. The Climate Moisture index (CMI) for the Eastern Nile region and the Nile Equatorial lakes varies significantly across the different General Circulation Models (GCM)[2]. Such high uncertainty casts a shadow on the plans to expand hydropower capacity, doubting whether hydropower expansion can contribute to the goal of improving access to electricity or end up as sunk investments. In this assessment, we analyze adaptation strategies for national energy systems in the Eastern African Power Pool (EAPP), which minimize the regret that could potentially arise from impacts of a changed climate. An energy systems model of the EAPP is developed representing national electricity supply infrastructure. Cross border transmission and hydropower infrastructure is defined at individual project level. The energy systems model is coupled with a water systems management model of the Nile River Basin that calculates the water availability at different hydropower infrastructures under a range of climate scenarios. The results suggest that a robust adaptation strategy consisting of investments in cross border electricity transmission infrastructure and diversifying sources of electricity supply will require additional investments of USD 4.2 billion by 2050. However, this leads to fuel and operational cost savings of up to USD 22.6 billion, depending on the climate scenario. [1] "Platts, 2016. World Electric Power Plants Database

  15. Vulnerability of hydropower generation to climate change in China: Results based on Grey forecasting model

    International Nuclear Information System (INIS)

    Wang, Bing; Liang, Xiao-Jie; Zhang, Hao; Wang, Lu; Wei, Yi-Ming

    2014-01-01

    This paper analyzes the long-term relationships between hydropower generation and climate factors (precipitation), hydropower generation capacity (installed capacity of hydropower station) to quantify the vulnerability of renewable energy production in China for the case of hydropower generation. Furthermore, this study applies Grey forecasting model to forecast precipitation in different provinces, and then sets up different scenarios for precipitation based on the IPCC Special Report on Emission Scenarios and results from PRECIS (Providing Regional Climate projections for Impacts Studies) model. The most important result found in this research is the increasing hydropower vulnerability of the poorest regions and the main hydropower generation provinces of China to climate change. Other main empirical results reveal that the impacts of climate change on the supply of hydropower generation in China will be noteworthy for the society. Different scenarios have different effects on hydropower generation, of which A2 scenario (pessimistic, high emission) has the largest. Meanwhile, the impacts of climate change on hydropower generation of every province are distinctly different, of which the Southwest part has the higher vulnerability than the average level while the central part lower. - Highlights: • The hydropower vulnerability will be enlarged with the rapid increase of hydropower capacity. • Modeling the vulnerability of hydropower in different scenarios and different provinces. • The increasing hydropower vulnerability of the poorest regions to climate change. • The increasing hydropower vulnerability of the main hydropower generation provinces. • Rainfall pattern caused by climate change would be the reason for the increasing vulnerability

  16. Incorporating socio-environmental considerations into project assessment models using multi-criteria analysis: A case study of Sri Lankan hydropower projects

    International Nuclear Information System (INIS)

    Morimoto, Risako

    2013-01-01

    Before commissioning any energy projects, conducting robust assessments of different options in terms of their economic and socio-environmental impacts is important for successful project implementation. Yet, there is currently a lack of tools that simultaneously assess sustainability impacts; instead, they are often investigated separately, which gives decision makers somehow disintegrated information. Thus the main objective of this study is to examine how to incorporate socio-environmental considerations into project assessment models. The multi-criteria analysis is applied to the case study of Sri Lankan hydropower projects as an illustrative example. The estimated quantitative relationship between economic, environmental and social impacts of hydropower development is presented in this study. Such estimation, using sustainability indicators of hydropower projects, enables us to understand marginal trade-offs among economic, environmental and social objectives of hydropower development. Hence, this would provide an overview of potential impacts of different scenarios that are designed to be implemented and indicate an optimum mix of hydropower generation. - Highlights: • This study provides an effective hydropower project evaluation method using the MCA. • The proposed tool shows the quantitative relationship explicitly. • Marginal trade-offs between sustainability objectives are presented

  17. An approach to the investment analysis of small and medium hydro-power plants

    International Nuclear Information System (INIS)

    Forouzbakhsh, F.; Hosseini, S.M.H.; Vakilian, M.

    2007-01-01

    Hydro-power plants, as a part of infrastructure projects, play an important role in the economic-social development of countries. Since a large amount of investment is needed for construction of these power plants, which appeared to be an obstacle in these developments, however it is possible to finance these infrastructure plants by assigning these affairs to private sectors by using build operate transfer (BOT) method, which is quite well-known all around the world. This paper reviews the structure of BOT contracts and through an economic evaluation based on different percentage of investments of private sector in providing the expenses of small and medium hydro-power plants (S and M-HPP) (e.g. MHPP in 'Bookan, Iran' and SHPP in 'Nari, Iran'), demonstrates that by increasing the percentage the share of the private sector in the investment, the economic indices B/C and NPV improve substantially

  18. Small hydropower station in Schluein, Switzerland

    International Nuclear Information System (INIS)

    Merz, F.; Thoeny, F.

    2007-04-01

    This preliminary study elaborated for the Swiss Federal Office of Energy (SFOE) describes a project concerning the building of a small-scale hydropower installation in Schluein in the Grisons, Switzerland. The requirements placed on the water intake point in this mountainous region are discussed. The installation includes a 1230 metre long pressurised conduit and uses a multi-jet Pelton turbine to provide 720 kW of electrical power, the hydraulic head amounting to 140 m. The paper discusses the amounts of water available over the year, production costs and the economic feasibility of the project. The power production is estimated to 3,150,000 kWh/y. Environmental aspects are examined and details still to be defined are briefly mentioned.

  19. Hydrogen production at hydro-power plants

    Science.gov (United States)

    Tarnay, D. S.

    A tentative design for hydrogen-producing installations at hydropower facilities is discussed from technological, economic and applications viewpoints. The plants would use alternating current to electrolyze purified river water. The hydrogen would be stored in gas or liquid form and oxygen would be sold or vented to the atmosphere. The hydrogen could later be burned in a turbine generator for meeting peak loads, either in closed or open cycle systems. The concept would allow large hydroelectric plants to function in both base- and peak-load modes, thus increasing the hydraulic utilization of the plant and the capacity factor to a projected 0.90. Electrolyzer efficiencies ranging from 0.85-0.90 have been demonstrated. Excess hydrogen can be sold for other purposes or, eventually, as domestic and industrial fuel, at prices competitive with current industrial hydrogen.

  20. Multi-impact evaluation of new medium and large hydropower plants in Portugal centre region

    OpenAIRE

    Almeida, Aníbal T. de; Moura, Pedro S.; Marques, Alféu S.; Almeida, José L. de

    2005-01-01

    Traditionally, the decision criteria when analyzing hydropower plants projects, has been based mostly on technical and economical analyses focused on the electric production aspects. Nowadays a broader approach is necessary, which takes into consideration multiple impacts such as:- Energy impacts;- Water resources impacts;- Social-economics development impacts;- Agricultural sector impacts;- Environmental impacts. http://www.sciencedirect.com/science/article/B6VMY-4BVNW1W-1/1/d7275b5487efa...

  1. Modelling and simulation of floods in alpine catchments equipped with complex hydropower schemes

    OpenAIRE

    Bieri, Martin; Schleiss, Anton; Frankhauser, A.

    2010-01-01

    The simulation of run-off in an alpine catchment area equipped with complex hydropower schemes is presented by the help of an especially developed tool, called Routing System, which can combine hydrological modelling and operation of hydraulic elements. In the hydrological forecasting tool tridimensional rainfall, temperature and evapotranspiration distributions are taken into account for simulating the dominant hydrological processes, as glacier melt, snow pack constitution and melt, soil in...

  2. Sustainable hydropower in Lower Mekong Countries: Technical assessment and training travel report

    Energy Technology Data Exchange (ETDEWEB)

    Hadjerioua, Boualem [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Witt, Adam M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-08-01

    The U.S. Agency for International Development (USAID), through their partnership with the U.S. Department of the Interior (DOI), requested the support of Oak Ridge National Laboratory (ORNL) to provide specialized technical assistance as part of the Smart Infrastructure for the Mekong (SIM) Program in Thailand. Introduced in July 2013 by U.S. Secretary of State John Kerry, SIM is a U.S. Government Inter-Agency program that provides Lower Mekong partner countries with targeted, demand-driven technical and scientific assistance to support environmentally sound, climate conscious and socially equitable infrastructure, clean energy development, and water resources optimization. The U.S. Government is committed to supporting sustainable economic development within the region by providing tools, best practices, technical assistance, and lessons learned for the benefit of partner countries. In response to a request from the Electricity Generating Authority of Thailand (EGAT), a SIM project was developed with two main activities: 1) to promote hydropower sustainability and efficiency through technical assessment training at two existing hydropower assets in Thailand, and 2) the design and implementation of one national and two or three regional science and policy workshops, to be co-hosted with EGAT, to build common understanding of and commitment to environmental and social safeguards for Mekong Basin hydropower projects. The U.S. Department of Energy (DOE) is leading the technical assessment (Activity 1), and has contracted ORNL to provide expert technical assistance focused on increasing efficiency at existing projects, with the goal of increasing renewable energy generation at little to no capital cost. ORNL is the leading national laboratory in hydropower analysis, with a nationally recognized and highly qualified team of scientists addressing small to large-scale systems (basin-, regional-, and national-scale) energy generation optimization analysis for DOE. The

  3. Dynamical nexus of water supply, hydropower and environment based on the modeling of multiple socio-natural processes: from socio-hydrological perspective

    Science.gov (United States)

    Liu, D.; Wei, X.; Li, H. Y.; Lin, M.; Tian, F.; Huang, Q.

    2017-12-01

    In the socio-hydrological system, the ecological functions and environmental services, which are chosen to maintain, are determined by the preference of the society, which is making the trade-off among the values of riparian vegetation, fish, river landscape, water supply, hydropower, navigation and so on. As the society develops, the preference of the value will change and the ecological functions and environmental services which are chosen to maintain will change. The aim of the study is to focus on revealing the feedback relationship of water supply, hydropower and environment and the dynamical feedback mechanism at macro-scale, and to establish socio-hydrological evolution model of the watershed based on the modeling of multiple socio-natural processes. The study will aim at the Han River in China, analyze the impact of the water supply and hydropower on the ecology, hydrology and other environment elements, and study the effect on the water supply and hydropower to ensure the ecological and environmental water of the different level. Water supply and ecology are usually competitive. In some reservoirs, hydropower and ecology are synergic relationship while they are competitive in some reservoirs. The study will analyze the multiple mechanisms to implement the dynamical feedbacks of environment to hydropower, set up the quantitative relationship description of the feedback mechanisms, recognize the dominant processes in the feedback relationships of hydropower and environment and then analyze the positive and negative feedbacks in the feedback networks. The socio-hydrological evolution model at the watershed scale will be built and applied to simulate the long-term evolution processes of the watershed of the current situation. Dynamical nexus of water supply, hydropower and environment will be investigated.

  4. assessment of the hydropower potential of kangimi reservoir

    African Journals Online (AJOL)

    2012-11-03

    Nov 3, 2012 ... other renewable energy sources such as wind, small or mini hydropower ... plied to Kaduna treatment plant during the periods of low flow in River .... following functional reservoir relationships that are very site specific: i.

  5. Stream Classification Tool User Manual: For Use in Applications in Hydropower-Related Evironmental Mitigation

    Energy Technology Data Exchange (ETDEWEB)

    McManamay, Ryan A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Troia, Matthew J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); DeRolph, Christopher R. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Samu, Nicole M. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2016-01-01

    Stream classifications are an inventory of different types of streams. Classifications help us explore similarities and differences among different types of streams, make inferences regarding stream ecosystem behavior, and communicate the complexities of ecosystems. We developed a nested, layered, and spatially contiguous stream classification to characterize the biophysical settings of stream reaches within the Eastern United States (~ 900,000 reaches). The classification is composed of five natural characteristics (hydrology, temperature, size, confinement, and substrate) along with several disturbance regime layers, and each was selected because of their relevance to hydropower mitigation. We developed the classification at the stream reach level using the National Hydrography Dataset Plus Version 1 (1:100k scale). The stream classification is useful to environmental mitigation for hydropower dams in multiple ways. First, it creates efficiency in the regulatory process by creating an objective and data-rich means to address meaningful mitigation actions. Secondly, the SCT addresses data gaps as it quickly provides an inventory of hydrology, temperature, morphology, and ecological communities for the immediate project area, but also surrounding streams. This includes identifying potential reference streams as those that are proximate to the hydropower facility and fall within the same class. These streams can potentially be used to identify ideal environmental conditions or identify desired ecological communities. In doing so, the stream provides some context for how streams may function, respond to dam regulation, and an overview of specific mitigation needs. Herein, we describe the methodology in developing each stream classification layer and provide a tutorial to guide applications of the classification (and associated data) in regulatory settings, such as hydropower (re)licensing.

  6. The structural insights of stem cell factor receptor (c-Kit interaction with tyrosine phosphatase-2 (Shp-2: An in silico analysis

    Directory of Open Access Journals (Sweden)

    Gurudutta Gangenahalli U

    2010-01-01

    Full Text Available Abstract Background Stem cell factor (SCF receptor c-Kit is recognized as a key signaling molecule, which transduces signals for the proliferation, differentiation and survival of stem cells. Binding of SCF to its receptor triggers transactivation, leading to the recruitment of kinases and phosphatases to the docking platforms of c-Kit catalytic domain. Tyrosine phosphatase-1 (Shp-1 deactivates/attenuates 'Kit' kinase activity. Whereas, Asp816Val mutation in the Kit activation loop transforms kinase domain to a constitutively activated state (switch off-to-on state, in a ligand-independent manner. This phenomenon completely abrogates negative regulation of Shp-1. To predict the possible molecular basis of interaction between c-Kit and Shp-1, we have performed an in silico protein-protein docking study between crystal structure of activated c-Kit (phosphorylated c-Kit and full length crystal structure of Shp-2, a close structural counterpart of Shp-1. Findings Study revealed a stretch of conserved amino acids (Lys818 to Ser821 in the Kit activation domain, which makes decisive H-bonds with N-sh2 and phosphotyrosine binding pocket residues of the phosphatase. These H-bonds may impose an inhibitory steric hindrance to the catalytic domain of c-Kit, there by blocking further interaction of the activation loop molecules with incoming kinases. We have also predicted a phosphotyrosine binding pocket in SH2 domains of Shp-1, which is found to be predominantly closer to a catalytic groove like structure in c-Kit kinase domain. Conclusions This study predicts that crucial hydrogen bonding between N-sh2 domain of Shp-1 and Kit activation loop can modulate the negative regulation of c-Kit kinase by Shp-1. Thus, this finding is expected to play a significant role in designing suitable gain-of-function c-Kit mutants for inducing conditional proliferation of hematopoietic stem cells.

  7. A real option analysis of investments in hydropower-The case of Norway

    International Nuclear Information System (INIS)

    Kjaerland, Frode

    2007-01-01

    This paper presents a valuation study of hydropower investment opportunities in the Norwegian context. According to NVE (Norwegian Water Resources and Energy Directorate, the regulator), there is a potential of 39 TWh not yet developed (generation in a normal year is approximately 120 TWh). By using the conceptual real option framework of Dixit and Pindyck [1994. Investment Under Uncertainty. Princeton University Press, Princeton, NJ] one can estimate the value of investment opportunities to NOK 11 million/GWh (EUR 1.4 million/GWh). Furthermore, the optimal trigger price for initiating an investment based on electricity forward prices is calculated to NOK 0.32/kWh (EUR 0.04/kWh). The analysis shows consistency between real option theory and aggregate investment behaviour in Norwegian hydropower

  8. Water-Energy Nexus in Shared River Basins: How Hydropower Shapes Cooperation and Coordination

    Directory of Open Access Journals (Sweden)

    Kouangpalath Phimthong

    2015-01-01

    Full Text Available The construction of hydropower plants on transboundary rivers is seldom done with equal benefits to all riparians, and therefore presents coordination and cooperation challenges. Without a supra-national authority in charge of transboundary river basins, coordination between sectors (water, energy and environment and cooperation between countries largely depends on willingness of the individual nation states and the power relations between these countries. This paper discusses how the interests and relative power positions of actors in transboundary water management shape the outcomes, and what roles are played by River Basin Organisations and foreign investors (especially in hydropower development. These issues are illustrated with examples from the Mekong river in Southeast Asia (Laos, Thailand, Cambodia and Vietnam, the Euphrates-Tigris (Turkey, Syria, Iraq, Iran and Kuwait and the Çoruh in Turkey and Georgia.

  9. Perspectives for hydropower in Switzerland - chances offered by the 'green power' market

    International Nuclear Information System (INIS)

    Spreng, D.; Truffer, B.; Wuestenhagen, R.

    2003-01-01

    This short article discusses the chances offered to operators of hydropower stations by 'green power' markets for the sale of power produced under strict conditions in environment-friendly power generation facilities. The development of these markets is discussed as are the interdependencies between the public's use of green power markets and measures taken by the state to promote the use of renewable forms of energy. The results of market research on customer willingness to purchase environment-friendly electricity are discussed and the important role of hydropower in this business is stressed. The differing interests of various customer segments are discussed and the part played by 'green stocks' and other sustainable investments in the financial market is looked at

  10. Bridging the Information Gap: Remote Sensing and Micro Hydropower Feasibility in Data-Scarce Regions

    Science.gov (United States)

    Muller, Marc Francois

    Access to electricity remains an impediment to development in many parts of the world, particularly in rural areas with low population densities and prohibitive grid extension costs. In that context, community-scale run-of-river hydropower---micro-hydropower---is an attractive local power generation option, particularly in mountainous regions, where appropriate slope and runoff conditions occur. Despite their promise, micro hydropower programs have generally failed to have a significant impact on rural electrification in developing nations. In Nepal, despite very favorable conditions and approximately 50 years of experience, the technology supplies only 4% of the 10 million households that do not have access to the central electricity grid. These poor results point towards a major information gap between technical experts, who may lack the incentives or local knowledge needed to design appropriate systems for rural villages, and local users, who have excellent knowledge of the community but lack technical expertise to design and manage infrastructure. Both groups suffer from a limited basis for evidence-based decision making due to sparse environmental data available to support the technical components of infrastructure design. This dissertation draws on recent advances in remote sensing data, stochastic modeling techniques and open source platforms to bridge that information gap. Streamflow is a key environmental driver of hydropower production that is particularly challenging to model due to its stochastic nature and the complexity of the underlying natural processes. The first part of the dissertation addresses the general challenge of Predicting streamflow in Ungauged Basins (PUB). It first develops an algorithm to optimize the use of rain gauge observations to improve the accuracy of remote sensing precipitation measures. It then derives and validates a process-based model to estimate streamflow distribution in seasonally dry climates using the stochastic

  11. Modeling Multi-Reservoir Hydropower Systems in the Sierra Nevada with Environmental Requirements and Climate Warming

    Science.gov (United States)

    Rheinheimer, David Emmanuel

    Hydropower systems and other river regulation often harm instream ecosystems, partly by altering the natural flow and temperature regimes that ecosystems have historically depended on. These effects are compounded at regional scales. As hydropower and ecosystems are increasingly valued globally due to growing values for clean energy and native species as well as and new threats from climate warming, it is important to understand how climate warming might affect these systems, to identify tradeoffs between different water uses for different climate conditions, and to identify promising water management solutions. This research uses traditional simulation and optimization to explore these issues in California's upper west slope Sierra Nevada mountains. The Sierra Nevada provides most of the water for California's vast water supply system, supporting high-elevation hydropower generation, ecosystems, recreation, and some local municipal and agricultural water supply along the way. However, regional climate warming is expected to reduce snowmelt and shift runoff to earlier in the year, affecting all water uses. This dissertation begins by reviewing important literature related to the broader motivations of this study, including river regulation, freshwater conservation, and climate change. It then describes three substantial studies. First, a weekly time step water resources management model spanning the Feather River watershed in the north to the Kern River watershed in the south is developed. The model, which uses the Water Evaluation And Planning System (WEAP), includes reservoirs, run-of-river hydropower, variable head hydropower, water supply demand, and instream flow requirements. The model is applied with a runoff dataset that considers regional air temperature increases of 0, 2, 4 and 6 °C to represent historical, near-term, mid-term and far-term (end-of-century) warming. Most major hydropower turbine flows are simulated well. Reservoir storage is also

  12. Hydropower harvesting from a small scale reciprocating system

    Energy Technology Data Exchange (ETDEWEB)

    Malla, Ramesh B.; Shrestha, Binu; Bagtzoglou, Amvrossios; Drasdis, Jonathon [Department of Civil and Environmental Engineering, University of Connecticut, 261 Glenbrook Road, Storrs, CT 06269-2037 (United States); Johnson, Paul [eGen LLC, 1084 Shennecossett Road, Groton, CT 06340 (United States)

    2011-05-15

    Conventional hydropower systems that can take advantage of low head movement of water require substantial flow rates. However, these systems cannot harvest hydro energy from small sources of water with low head and low discharge, such as streams and creeks. The reciprocating hydropower system discussed in this paper can harvest power from such low flow discharge and low head sources. This paper presents a detailed proof-of-concept study of the hydropower model, including the underlining theoretical principles. Laboratory test results demonstrating the dependence of the lift force in the reciprocating small scale hydropower model as a function of flow velocity, size and rotational speed of the cylinder and comparison of the results with a previous study are also included. Two methods of power harvesting from the output displacement obtained from the hydropower system are discussed. The first employs electromagnetic induction principles and the other is based on a linear inertial generator using a conventional second order spring mass damper system. Finally, results from a finite element analysis of the hydropower system are presented and facilitate future design of the structural aspects of the housing for the reciprocating cylinder. (author)

  13. Addressing biogenic greenhouse gas emissions from hydropower in LCA.

    Science.gov (United States)

    Hertwich, Edgar G

    2013-09-03

    The ability of hydropower to contribute to climate change mitigation is sometimes questioned, citing emissions of methane and carbon dioxide resulting from the degradation of biogenic carbon in hydropower reservoirs. These emissions are, however, not always addressed in life cycle assessment, leading to a bias in technology comparisons, and often misunderstood. The objective of this paper is to review and analyze the generation of greenhouse gas emissions from reservoirs for the purpose of technology assessment, relating established emission measurements to power generation. A literature review, data collection, and statistical analysis of methane and CO2 emissions are conducted. In a sample of 82 measurements, methane emissions per kWh hydropower generated are log-normally distributed, ranging from micrograms to 10s of kg. A multivariate regression analysis shows that the reservoir area per kWh electricity is the most important explanatory variable. Methane emissions flux per reservoir area are correlated with the natural net primary production of the area, the age of the power plant, and the inclusion of bubbling emissions in the measurement. Even together, these factors fail to explain most of the variation in the methane flux. The global average emissions from hydropower are estimated to be 85 gCO2/kWh and 3 gCH4/kWh, with a multiplicative uncertainty factor of 2. GHG emissions from hydropower can be largely avoided by ceasing to build hydropower plants with high land use per unit of electricity generated.

  14. Short-term forecasting model for aggregated regional hydropower generation

    International Nuclear Information System (INIS)

    Monteiro, Claudio; Ramirez-Rosado, Ignacio J.; Fernandez-Jimenez, L. Alfredo

    2014-01-01

    Highlights: • Original short-term forecasting model for the hourly hydropower generation. • The use of NWP forecasts allows horizons of several days. • New variable to represent the capacity level for generating hydroelectric energy. • The proposed model significantly outperforms the persistence model. - Abstract: This paper presents an original short-term forecasting model of the hourly electric power production for aggregated regional hydropower generation. The inputs of the model are previously recorded values of the aggregated hourly production of hydropower plants and hourly water precipitation forecasts using Numerical Weather Prediction tools, as well as other hourly data (load demand and wind generation). This model is composed of three modules: the first one gives the prediction of the “monthly” hourly power production of the hydropower plants; the second module gives the prediction of hourly power deviation values, which are added to that obtained by the first module to achieve the final forecast of the hourly hydropower generation; the third module allows a periodic adjustment of the prediction of the first module to improve its BIAS error. The model has been applied successfully to the real-life case study of the short-term forecasting of the aggregated hydropower generation in Spain and Portugal (Iberian Peninsula Power System), achieving satisfactory results for the next-day forecasts. The model can be valuable for agents involved in electricity markets and useful for power system operations

  15. Hydropower and biomass as renewable energy sources in Turkey

    International Nuclear Information System (INIS)

    Kaygusuz, K.

    2001-01-01

    When talking about renewable energy sources today, the most important and economical energy sources for Turkey are hydropower and biomass.The present study gives a review of production, consumption, and economics of hydropower and biomass as renewable energy sources in Turkey. Turkey has a total gross hydropower potential of 433 GW, but only 125 GW of the total hydroelectric potential of Turkey can be economically used. By the commissioning of new hydropower plants, which are under construction, 36% of the economically usable potential of the country could be tapped. On the other hand, biomass (wood and wastes) energy is the second most important renewable energy source for Turkey. However, the biomass energy sources of Turkey are limited. In 1998, the biomass share of the total energy consumption of the country is 10%. In this study, the potential of important biomass energy sources and animal solid wastes of the country were determined. The effects of hydropower and biomass usage on the environment were also discussed. Considering total cereal products and fatty seed plants, approximately 50-60 million tons per year of biomass and 8-10 million tons of solid matter animal waste are produced, and 70% of total biomass is seen as being usable for energy. Some useful suggestions and recommendations are also presented. The present study shows that there is an important potential for hydropower and biomass energy sources in Turkey. (author)

  16. Hydropower assessment of Bolivia—A multisource satellite data and hydrologic modeling approach

    Science.gov (United States)

    Velpuri, Naga Manohar; Pervez, Shahriar; Cushing, W. Matthew

    2016-11-28

    This study produced a geospatial database for use in a decision support system by the Bolivian authorities to investigate further development and investment potentials in sustainable hydropower in Bolivia. The study assessed theoretical hydropower of all 1-kilometer (km) stream segments in the country using multisource satellite data and a hydrologic modeling approach. With the assessment covering the 2 million square kilometer (km2) region influencing Bolivia’s drainage network, the potential hydropower figures are based on theoretical yield assuming that the systems generating the power are 100 percent efficient. There are several factors to consider when determining the real-world or technical power potential of a hydropower system, and these factors can vary depending on local conditions. Since this assessment covers a large area, it was necessary to reduce these variables to the two that can be modeled consistently throughout the region, streamflow or discharge, and elevation drop or head. First, the Shuttle Radar Topography Mission high-resolution 30-meter (m) digital elevation model was used to identify stream segments with greater than 10 km2 of upstream drainage. We applied several preconditioning processes to the 30-m digital elevation model to reduce errors and improve the accuracy of stream delineation and head height estimation. A total of 316,500 1-km stream segments were identified and used in this study to assess the total theoretical hydropower potential of Bolivia. Precipitation observations from a total of 463 stations obtained from the Bolivian Servicio Nacional de Meteorología e Hidrología (Bolivian National Meteorology and Hydrology Service) and the Brazilian Agência Nacional de Águas (Brazilian National Water Agency) were used to validate six different gridded precipitation estimates for Bolivia obtained from various sources. Validation results indicated that gridded precipitation estimates from the Tropical Rainfall Measuring Mission

  17. A light left in the dark: The practice and politics of pico-hydropower in the Lao PDR

    NARCIS (Netherlands)

    Smits, M.; Bush, S.R.

    2010-01-01

    The article describes the widespread use of an estimated 60,000 low-head pico-hydropower turbines and well-developed networks of supply and support in the Northern part of the Lao People's Democratic Republic (Lao PDR). This apparent widespread use is contrasted with the policy narratives of key

  18. Constitutive MHC class I molecules negatively regulate TLR-triggered inflammatory responses via the Fps-SHP-2 pathway.

    Science.gov (United States)

    Xu, Sheng; Liu, Xingguang; Bao, Yan; Zhu, Xuhui; Han, Chaofeng; Zhang, Peng; Zhang, Xuemin; Li, Weihua; Cao, Xuetao

    2012-04-22

    The molecular mechanisms that fine-tune Toll-like receptor (TLR)-triggered innate inflammatory responses remain to be fully elucidated. Major histocompatibility complex (MHC) molecules can mediate reverse signaling and have nonclassical functions. Here we found that constitutively expressed membrane MHC class I molecules attenuated TLR-triggered innate inflammatory responses via reverse signaling, which protected mice from sepsis. The intracellular domain of MHC class I molecules was phosphorylated by the kinase Src after TLR activation, then the tyrosine kinase Fps was recruited via its Src homology 2 domain to phosphorylated MHC class I molecules. This led to enhanced Fps activity and recruitment of the phosphatase SHP-2, which interfered with TLR signaling mediated by the signaling molecule TRAF6. Thus, constitutive MHC class I molecules engage in crosstalk with TLR signaling via the Fps-SHP-2 pathway and control TLR-triggered innate inflammatory responses.

  19. Recruitment of SHP-1 protein tyrosine phosphatase and signalling by a chimeric T-cell receptor-killer inhibitory receptor

    DEFF Research Database (Denmark)

    Christensen, M D; Geisler, C

    2000-01-01

    Receptors expressing the immunoreceptor tyrosine-based inhibitory motif (ITIM) in their cytoplasmic tail play an important role in the negative regulation of natural killer and B-cell activation. A subpopulation of T cells expresses the ITIM containing killer cell inhibitory receptor (KIR), which...... recognize MHC class I molecules. Following coligation of KIR with an activating receptor, the tyrosine in the ITIM is phosphorylated and the cytoplasmic protein tyrosine phosphatase SHP-1 is recruited to the ITIM via its SH2 domains. It is still not clear how SHP-1 affects T-cell receptor (TCR) signalling...... regarding total protein tyrosine phosphorylation, TCR down-regulation, mobilization of intracellular free calcium, or induction of the activation markers CD69 and CD25....

  20. Efficient operation of a multi-purpose reservoir in Chile: Tradeoffs between irrigation and hydropower production

    Science.gov (United States)

    Gonzalez Cabrera, J. M., Sr.; Olivares, M. A.

    2015-12-01

    This study proposes a method to develop efficient operational policies for a reservoir the southern Chile. The main water uses in this system are hydropower and irrigation, with conflicting seasonal demands. The conflict between these two uses is currently managed through a so-called "irrigation agreement" which defines a series of operational conditions on the reservoir by restricting volumes used for power production depending on reservoir storage level. Other than that, the reservoir operation is driven by cost-minimization over the power grid. Recent evidence shows an increasing degree of conflict in this basin, which suggests that the static approach of irrigation agreements, might no longer be appropriate. Moreover, this agreement could be revised in light of decreased water availability. This problem poses a challenge related to the spatial scope of analysis. Thus, irrigation benefits are driven by decisions made within the basin, whereas hydropower benefits depend on the operation of the entire power grid. Exploring the tradeoffs between these two water uses involves modeling both scales. The proposed methodology integrates information from both a grid-wide power operations model and a basin-wide agro-economic model into a decision model for optimal reservoir operation. The first model, a hydrothermal coordination tool, schedules power production by each plant in the grid, and allows capturing technical and economic aspects to the operation of hydropower reservoirs. The agro-economic model incorporates economic features of irrigation in the basin, and allows obtaining irrigation water demand functions. Finally, the results of both models are integrated into a single model for optimal reservoir operation considering the tradeoffs between the two uses. The result of the joint operation of water resources, show a flexible coordination of uses, revealing the opportunity cost of irrigation, which it gives the possibility of negotiating transfers of water to

  1. Detecting Human Hydrologic Alteration from Diversion Hydropower Requires Universal Flow Prediction Tools: A Proposed Framework for Flow Prediction in Poorly-gauged, Regulated Rivers

    Science.gov (United States)

    Kibler, K. M.; Alipour, M.

    2016-12-01

    Achieving the universal energy access Sustainable Development Goal will require great investment in renewable energy infrastructure in the developing world. Much growth in the renewable sector will come from new hydropower projects, including small and diversion hydropower in remote and mountainous regions. Yet, human impacts to hydrological systems from diversion hydropower are poorly described. Diversion hydropower is often implemented in ungauged rivers, thus detection of impact requires flow analysis tools suited to prediction in poorly-gauged and human-altered catchments. We conduct a comprehensive analysis of hydrologic alteration in 32 rivers developed with diversion hydropower in southwestern China. As flow data are sparse, we devise an approach for estimating streamflow during pre- and post-development periods, drawing upon a decade of research into prediction in ungauged basins. We apply a rainfall-runoff model, parameterized and forced exclusively with global-scale data, in hydrologically-similar gauged and ungauged catchments. Uncertain "soft" data are incorporated through fuzzy numbers and confidence-based weighting, and a multi-criteria objective function is applied to evaluate model performance. Testing indicates that the proposed framework returns superior performance (NSE = 0.77) as compared to models parameterized by rote calibration (NSE = 0.62). Confident that the models are providing `the right answer for the right reasons', our analysis of hydrologic alteration based on simulated flows indicates statistically significant hydrologic effects of diversion hydropower across many rivers. Mean annual flows, 7-day minimum and 7-day maximum flows decreased. Frequency and duration of flow exceeding Q25 decreased while duration of flows sustained below the Q75 increased substantially. Hydrograph rise and fall rates and flow constancy increased. The proposed methodology may be applied to improve diversion hydropower design in data-limited regions.

  2. Runoff and Sediment Response to Cascade Hydropower Exploitation in the Middle and Lower Han River, China

    Directory of Open Access Journals (Sweden)

    Junhong Zhang

    2017-01-01

    Full Text Available With the rapid development of hydropower exploitation in China, changes in runoff and sediment transport have become a significant issue that cannot be neglected. In this study, the Han River was selected as a study case, where the runoff variation and changes in sediment load at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations were analyzed in different time periods. The results indicate that impact of cascade hydropower exploitation on runoff and sediment transport is significantly different even during the same time periods. After reservoir regulation, the decreasing of sediment load is faster than that of runoff. Strong positive correlation between runoff and sediment load exists during different time periods, while reservoir operation leads to different turning points at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations in the middle and lower Han River. As a key driving factor, runoff variation contributed to sediment transport with different impact index CR. The impact index CR before and after the first change point at the Baihe, Huangjiagang, Huangzhuang, and Xiantao stations is 43.35%, −3.68%, 11.17%, and 30.12%, respectively. This study helps us understand and evaluate the hydrological changes under cascade hydropower exploitation in the middle and lower Han River.

  3. Optimal short-term operation schedule of a hydropower plant in a competitive electricity market

    International Nuclear Information System (INIS)

    Perez-Diaz, Juan I.; Wilhelmi, Jose R.; Arevalo, Luis A.

    2010-01-01

    This paper presents a dynamic programming model to solve the short-term scheduling problem of a hydropower plant that sells energy in a pool-based electricity market with the objective of maximizing the revenue. This is a nonlinear and non-concave problem subject to strong technical and strategic constraints, and in which discrete and continuous variables take part. The model described in this paper determines, in each hour of the planning horizon (typically from one day to one week), both the optimal number of units in operation (unit commitment) and the power to be generated by the committed units (generation dispatch). The power generated by each unit is considered as a nonlinear function of the actual water discharge and volume of the associated reservoir. The dependence of the units' efficiency and operating limits with the available gross head is also accounted for in this model. The application of this model to a real hydropower plant demonstrates its capabilities in providing the operation schedule that maximizes the revenue of the hydro plant while satisfying several constraints of different classes. In addition, the use of this model as a supporting tool to estimate the economic feasibility of a hydropower plant development project is also analyzed in the paper. (author)

  4. Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.

    Directory of Open Access Journals (Sweden)

    Shing Hwa Liu

    Full Text Available BACKGROUND: Honokiol, a small-molecular weight natural product, has previously been reported to activate apoptosis and inhibit gastric tumorigenesis. Whether honokiol inhibits the angiogenesis and metastasis of gastric cancer cells remains unknown. METHODOLOGY/PRINCIPAL FINDINGS: We tested the effects of honokiol on angiogenic activity and peritoneal dissemination using in vivo, ex vivo and in vitro assay systems. The signaling responses in human gastric cancer cells, human umbilical vascular endothelial cells (HUVECs, and isolated tumors were detected and analyzed. In a xenograft gastric tumor mouse model, honokiol significantly inhibited the peritoneal dissemination detected by PET/CT technique. Honokiol also effectively attenuated the angiogenesis detected by chick chorioallantoic membrane assay, mouse matrigel plug assay, rat aortic ring endothelial cell sprouting assay, and endothelial cell tube formation assay. Furthermore, honokiol effectively enhanced signal transducer and activator of transcription (STAT-3 dephosphorylation and inhibited STAT-3 DNA binding activity in human gastric cancer cells and HUVECs, which was correlated with the up-regulation of the activity and protein expression of Src homology 2 (SH2-containing tyrosine phosphatase-1 (SHP-1. Calpain-II inhibitor and siRNA transfection significantly reversed the honokiol-induced SHP-1 activity. The decreased STAT-3 phosphorylation and increased SHP-1 expression were also shown in isolated peritoneal metastatic tumors. Honokiol was also capable of inhibiting VEGF generation, which could be reversed by SHP-1 siRNA transfection. CONCLUSIONS/SIGNIFICANCE: Honokiol increases expression and activity of SPH-1 that further deactivates STAT3 pathway. These findings also suggest that honokiol is a novel and potent inhibitor of angiogenesis and peritoneal dissemination of gastric cancer cells, providing support for the application potential of honokiol in gastric cancer therapy.

  5. Noonan syndrome-causing SHP2 mutants impair ERK-dependent chondrocyte differentiation during endochondral bone growth.

    Science.gov (United States)

    Tajan, Mylène; Pernin-Grandjean, Julie; Beton, Nicolas; Gennero, Isabelle; Capilla, Florence; Neel, Benjamin G; Araki, Toshiyuki; Valet, Philippe; Tauber, Maithé; Salles, Jean-Pierre; Yart, Armelle; Edouard, Thomas

    2018-04-12

    Growth retardation is a constant feature of Noonan syndrome (NS) but its physiopathology remains poorly understood. We previously reported that hyperactive NS-causing SHP2 mutants impair the systemic production of insulin-like growth factor 1 (IGF1) through hyperactivation of the RAS/extracellular signal-regulated kinases (ERK) signalling pathway. Besides endocrine defects, a direct effect of these mutants on growth plate has not been explored, although recent studies have revealed an important physiological role for SHP2 in endochondral bone growth. We demonstrated that growth plate length was reduced in NS mice, mostly due to a shortening of the hypertrophic zone and to a lesser extent of the proliferating zone. These histological features were correlated with decreased expression of early chondrocyte differentiation markers, and with reduced alkaline phosphatase staining and activity, in NS murine primary chondrocytes. Although IGF1 treatment improved growth of NS mice, it did not fully reverse growth plate abnormalities, notably the decreased hypertrophic zone. In contrast, we documented a role of RAS/ERK hyperactivation at the growth plate level since 1) NS-causing SHP2 mutants enhance RAS/ERK activation in chondrocytes in vivo (NS mice) and in vitro (ATDC5 cells) and 2) inhibition of RAS/ERK hyperactivation by U0126 treatment alleviated growth plate abnormalities and enhanced chondrocyte differentiation. Similar effects were obtained by chronic treatment of NS mice with statins.In conclusion, we demonstrated that hyperactive NS-causing SHP2 mutants impair chondrocyte differentiation during endochondral bone growth through a local hyperactivation of the RAS/ERK signalling pathway, and that statin treatment may be a possible therapeutic approach in NS.

  6. Regulation of nasal airway homeostasis and inflammation in mice by SHP-1 and Th2/Th1 signaling pathways.

    Directory of Open Access Journals (Sweden)

    Seok Hyun Cho

    Full Text Available Allergic rhinitis is a chronic inflammatory disease orchestrated by Th2 lymphocytes. Src homology 2 domain-containing protein tyrosine phosphatase (SHP-1 is known to be a negative regulator in the IL-4α/STAT-6 signaling pathway of the lung. However, the role of SHP-1 enzyme and its functional relationship with Th2 and Th1 cytokines are not known in the nasal airway. In this study, we aimed to study the nasal inflammation as a result of SHP-1 deficiency in viable motheaten (mev mice and to investigate the molecular mechanisms involved. Cytology, histology, and expression of cytokines and chemokines were analyzed to define the nature of the nasal inflammation. Targeted gene depletion of Th1 (IFN-γ and Th2 (IL-4 and IL-13 cytokines was used to identify the critical pathways involved. Matrix metalloproteinases (MMPs were studied to demonstrate the clearance mechanism of recruited inflammatory cells into the nasal airway. We showed here that mev mice had a spontaneous allergic rhinitis-like inflammation with eosinophilia, mucus metaplasia, up-regulation of Th2 cytokines (IL-4 and IL-13, chemokines (eotaxin, and MMPs. All of these inflammatory mediators were clearly counter-regulated by Th2 and Th1 cytokines. Deletion of IFN-γ gene induced a strong Th2-skewed inflammation with transepithelial migration of the inflammatory cells. These findings suggest that SHP-1 enzyme and Th2/Th1 paradigm may play a critical role in the maintenance of nasal immune homeostasis and in the regulation of allergic rhinitis.

  7. Rgg-Shp regulators are important for pneumococcal colonization and invasion through their effect on mannose utilization and capsule synthesis.

    Science.gov (United States)

    Zhi, Xiangyun; Abdullah, Iman Tajer; Gazioglu, Ozcan; Manzoor, Irfan; Shafeeq, Sulman; Kuipers, Oscar P; Hiller, N Luisa; Andrew, Peter W; Yesilkaya, Hasan

    2018-04-23

    Microbes communicate with each other by using quorum sensing (QS) systems and modulate their collective 'behavior' for in-host colonization and virulence, biofilm formation, and environmental adaptation. The recent increase in genome data availability reveals the presence of several putative QS sensing circuits in microbial pathogens, but many of these have not been functionally characterized yet, despite their possible utility as drug targets. To increase the repertoire of functionally characterized QS systems in bacteria, we studied Rgg144/Shp144 and Rgg939/Shp939, two putative QS systems in the important human pathogen Streptococcus pneumoniae. We find that both of these QS circuits are induced by short hydrophobic peptides (Shp) upon sensing sugars found in the respiratory tract, such as galactose and mannose. Microarray analyses using cultures grown on mannose and galactose revealed that the expression of a large number of genes is controlled by these QS systems, especially those encoding for essential physiological functions and virulence-related genes such as the capsular locus. Moreover, the array data revealed evidence for cross-talk between these systems. Finally, these Rgg systems play a key role in colonization and virulence, as deletion mutants of these QS systems are attenuated in the mouse models of colonization and pneumonia.

  8. NOX4-dependent Hydrogen peroxide promotes shear stress-induced SHP2 sulfenylation and eNOS activation.

    Science.gov (United States)

    Sánchez-Gómez, Francisco J; Calvo, Enrique; Bretón-Romero, Rosa; Fierro-Fernández, Marta; Anilkumar, Narayana; Shah, Ajay M; Schröder, Katrin; Brandes, Ralf P; Vázquez, Jesús; Lamas, Santiago

    2015-12-01

    Laminar shear stress (LSS) triggers signals that ultimately result in atheroprotection and vasodilatation. Early responses are related to the activation of specific signaling cascades. We investigated the participation of redox-mediated modifications and in particular the role of hydrogen peroxide (H2O2) in the sulfenylation of redox-sensitive phosphatases. Exposure of vascular endothelial cells to short periods of LSS (12 dyn/cm(2)) resulted in the generation of superoxide radical anion as detected by the formation of 2-hydroxyethidium by HPLC and its subsequent conversion to H2O2, which was corroborated by the increase in the fluorescence of the specific peroxide sensor HyPer. By using biotinylated dimedone we detected increased total protein sulfenylation in the bovine proteome, which was dependent on NADPH oxidase 4 (NOX4)-mediated generation of peroxide. Mass spectrometry analysis allowed us to identify the phosphatase SHP2 as a protein susceptible to sulfenylation under LSS. Given the dependence of FAK activity on SHP2 function, we explored the role of FAK under LSS conditions. FAK activation and subsequent endothelial NO synthase (eNOS) phosphorylation were promoted by LSS and both processes were dependent on NOX4, as demonstrated in lung endothelial cells isolated from NOX4-null mice. These results support the idea that LSS elicits redox-sensitive signal transduction responses involving NOX4-dependent generation of hydrogen peroxide, SHP2 sulfenylation, and ulterior FAK-mediated eNOS activation. Copyright © 2015 Elsevier Inc. All rights reserved.

  9. A PTPN11 allele encoding a catalytically impaired SHP2 protein in a patient with a Noonan syndrome phenotype.

    Science.gov (United States)

    Edwards, Jonathan J; Martinelli, Simone; Pannone, Luca; Lo, Ivan Fai-Man; Shi, Lisong; Edelmann, Lisa; Tartaglia, Marco; Luk, Ho-Ming; Gelb, Bruce D

    2014-09-01

    The RASopathies are a relatively common group of phenotypically similar and genetically related autosomal dominant genetic syndromes caused by missense mutations affecting genes participating in the RAS/mitogen-activated protein kinase (MAPK) pathway that include Noonan syndrome (NS) and Noonan syndrome with multiple lentigines (NSML, formerly LEOPARD syndrome). NS and NSML can be difficult to differentiate during infancy, but the presence of multiple lentigines, café au lait spots, and specific cardiac defects facilitate the diagnosis. Furthermore, individual PTPN11 missense mutations are highly specific to each syndrome and engender opposite biochemical alterations on the function of SHP-2, the protein product of that gene. Here, we report on a 5-year-old male with two de novo PTPN11 mutations in cis, c.1471C>T (p.Pro491Ser), and c.1492C>T (p.Arg498Trp), which are associated with NS and NSML, respectively. This boy's phenotype is intermediate between NS and NSML with facial dysmorphism, short stature, mild global developmental delay, pulmonic stenosis, and deafness but absence of café au lait spots or lentigines. The double-mutant SHP-2 was found to be catalytically impaired. This raises the question of whether clinical differences between NS and NSML can be ascribed solely to the relative SHP-2 catalytic activity. © 2014 Wiley Periodicals, Inc.

  10. Estimation of the cost of electro-mechanical equipment for small hydropower plants – review and comparison of methods

    Directory of Open Access Journals (Sweden)

    Lipiński Seweryn

    2017-01-01

    Full Text Available The estimate of the cost of electro-mechanical equipment for new small hydropower plants most often amounts to about 30-40% of the total budget. In case of modernization of existing installations, this estimation represents the main cost. This matter constitutes a research problem for at least few decades. Many models have been developed for that purpose. The aim of our work was to collect and analyse formulas that allow estimation of the cost of investment in electro-mechanical equipment for small hydropower plants. Over a dozen functions were analysed. To achieve the aim of our work, these functions were converted into the form allowing their comparison. Then the costs were simulated with respect to plants’ powers and net heads; such approach is novel and allows deeper discussion of the problem, as well as drawing broader conclusions. The following conclusions can be drawn: significant differences in results obtained by using various formulas were observed; there is a need for a wide study based on national investments in small hydropower plants that would allow to develop equations based on local data; the obtained formulas would let to determinate the costs of modernization or a new construction of small hydropower plant more precisely; special attention should be payed to formulas considering turbine type.

  11. Metaheuristic Approaches for Hydropower System Scheduling

    Directory of Open Access Journals (Sweden)

    Ieda G. Hidalgo

    2015-01-01

    Full Text Available This paper deals with the short-term scheduling problem of hydropower systems. The objective is to meet the daily energy demand in an economic and safe way. The individuality of the generating units and the nonlinearity of their efficiency curves are taken into account. The mathematical model is formulated as a dynamic, mixed integer, nonlinear, nonconvex, combinatorial, and multiobjective optimization problem. We propose two solution methods using metaheuristic approaches. They combine Genetic Algorithm with Strength Pareto Evolutionary Algorithm and Ant Colony Optimization. Both approaches are divided into two phases. In the first one, to maximize the plant’s net generation, the problem is solved for each hour of the day (static dispatch. In the second phase, to minimize the units’ switching on-off, the day is considered as a whole (dynamic dispatch. The proposed methodology is applied to two Brazilian hydroelectric plants, in cascade, that belong to the national interconnected system. The nondominated solutions from both approaches are presented. All of them meet demand respecting the physical, electrical, and hydraulic constraints.

  12. Protein-tyrosine Phosphatase SHP2 Contributes to GDNF Neurotrophic Activity through Direct Binding to Phospho-Tyr687 in the RET Receptor Tyrosine Kinase*

    Science.gov (United States)

    Perrinjaquet, Maurice; Vilar, Marçal; Ibáñez, Carlos F.

    2010-01-01

    The signaling mechanisms by which neurotrophic receptors regulate neuronal survival and axonal growth are still incompletely understood. In the receptor tyrosine kinase RET, a receptor for GDNF (glial cell line-derived neurotrophic factor), the functions of the majority of tyrosine residues that become phosphorylated are still unknown. Here we have identified the protein-tyrosine phosphatase SHP2 as a novel direct interactor of RET and the first effector known to bind to phosphorylated Tyr687 in the juxtamembrane region of the receptor. We show that SHP2 is recruited to RET upon ligand binding in a cooperative fashion, such that both interaction with Tyr687 and association with components of the Tyr1062 signaling complex are required for stable recruitment of SHP2 to the receptor. SHP2 recruitment contributes to the ability of RET to activate the PI3K/AKT pathway and promote survival and neurite outgrowth in primary neurons. Furthermore, we find that activation of protein kinase A (PKA) by forskolin reduces the recruitment of SHP2 to RET and negatively affects ligand-mediated neurite outgrowth. In agreement with this, mutation of Ser696, a known PKA phosphorylation site in RET, enhances SHP2 binding to the receptor and eliminates the effect of forskolin on ligand-induced outgrowth. Together, these findings establish SHP2 as a novel positive regulator of the neurotrophic activities of RET and reveal Tyr687 as a critical platform for integration of RET and PKA signals. We anticipate that several other phosphotyrosines of unknown function in neuronal receptor tyrosine kinases will also support similar regulatory functions. PMID:20682772

  13. Protein-tyrosine phosphatase SHP2 contributes to GDNF neurotrophic activity through direct binding to phospho-Tyr687 in the RET receptor tyrosine kinase.

    Science.gov (United States)

    Perrinjaquet, Maurice; Vilar, Marçal; Ibáñez, Carlos F

    2010-10-08

    The signaling mechanisms by which neurotrophic receptors regulate neuronal survival and axonal growth are still incompletely understood. In the receptor tyrosine kinase RET, a receptor for GDNF (glial cell line-derived neurotrophic factor), the functions of the majority of tyrosine residues that become phosphorylated are still unknown. Here we have identified the protein-tyrosine phosphatase SHP2 as a novel direct interactor of RET and the first effector known to bind to phosphorylated Tyr(687) in the juxtamembrane region of the receptor. We show that SHP2 is recruited to RET upon ligand binding in a cooperative fashion, such that both interaction with Tyr(687) and association with components of the Tyr(1062) signaling complex are required for stable recruitment of SHP2 to the receptor. SHP2 recruitment contributes to the ability of RET to activate the PI3K/AKT pathway and promote survival and neurite outgrowth in primary neurons. Furthermore, we find that activation of protein kinase A (PKA) by forskolin reduces the recruitment of SHP2 to RET and negatively affects ligand-mediated neurite outgrowth. In agreement with this, mutation of Ser(696), a known PKA phosphorylation site in RET, enhances SHP2 binding to the receptor and eliminates the effect of forskolin on ligand-induced outgrowth. Together, these findings establish SHP2 as a novel positive regulator of the neurotrophic activities of RET and reveal Tyr(687) as a critical platform for integration of RET and PKA signals. We anticipate that several other phosphotyrosines of unknown function in neuronal receptor tyrosine kinases will also support similar regulatory functions.

  14. Natural gas price uncertainty and the cost-effectiveness of hedging against low hydropower revenues caused by drought

    Science.gov (United States)

    Kern, Jordan D.; Characklis, Gregory W.; Foster, Benjamin T.

    2015-04-01

    Prolonged periods of low reservoir inflows (droughts) significantly reduce a hydropower producer's ability to generate both electricity and revenues. Given the capital intensive nature of the electric power industry, this can impact hydropower producers' ability to pay down outstanding debt, leading to credit rating downgrades, higher interests rates on new debt, and ultimately, greater infrastructure costs. One potential tool for reducing the financial exposure of hydropower producers to drought is hydrologic index insurance, in particular, contracts structured to payout when streamflows drop below a specified level. An ongoing challenge in developing this type of insurance, however, is minimizing contracts' "basis risk," that is, the degree to which contract payouts deviate in timing and/or amount from actual damages experienced by policyholders. In this paper, we show that consideration of year-to-year changes in the value of hydropower (i.e., the cost of replacing it with an alternative energy source during droughts) is critical to reducing contract basis risk. In particular, we find that volatility in the price of natural gas, a key driver of peak electricity prices, can significantly degrade the performance of index insurance unless contracts are designed to explicitly consider natural gas prices when determining payouts. Results show that a combined index whose value is derived from both seasonal streamflows and the spot price of natural gas yields contracts that exhibit both lower basis risk and greater effectiveness in terms of reducing financial exposure.

  15. Rethinking Pumped Storage Hydropower in the European Alps: A Call for New Integrated Assessment Tools to Support the Energy Transition

    Directory of Open Access Journals (Sweden)

    Astrid Björnsen Gurung

    2016-05-01

    Full Text Available The European Alps are well positioned to contribute significantly to the energy transition. In addition to sites with above-average potential for wind and solar power, the “water towers” of Europe provide flexible, low-carbon power generation as well as energy storage. In the future, hydropower systems are expected to become more than mere electricity generators, serving a key role as flexible complements to intermittent power generators and as providers of large-scale seasonal and daily energy storage. Energy transition on national and European scales can be facilitated by expanding the capacity of pumped storage hydropower (PSHP plants. Yet the extension of hydropower production, in particular PSHP, remains controversial, primarily due to environmental concerns. Focusing on 2 Alpine countries, Austria and Switzerland, this paper provides a system view of hydropower production and energy storage in the Alps. It discusses advantages and drawbacks of various assessment tools and identifies gaps and needs for the integrated assessment of PSHP plants. It concludes that instruments that evaluate the impacts and sustainability of PSHP projects need to be developed, elaborated, and applied in a participatory manner, in order to promote public dialogue, increase social acceptance, and, ideally, encourage energy consumers to become advocates of a sustainable energy future.

  16. Multi-model assessment of global hydropower and cooling water discharge potential under climate change

    NARCIS (Netherlands)

    van Vliet, M. T H; van Beek, L. P H|info:eu-repo/dai/nl/14749799X; Eisner, S.; Flörke, M.; Wada, Y.|info:eu-repo/dai/nl/341387819; Bierkens, M. F P|info:eu-repo/dai/nl/125022794

    2016-01-01

    Worldwide, 98% of total electricity is currently produced by thermoelectric power and hydropower. Climate change is expected to directly impact electricity supply, in terms of both water availability for hydropower generation and cooling water usage for thermoelectric power. Improved understanding

  17. Organizing Environmental Flow Frameworks to Meet Hydropower Mitigation Needs

    Science.gov (United States)

    McManamay, Ryan A.; Brewer, Shannon K.; Jager, Henriette I.; Troia, Matthew J.

    2016-09-01

    The global recognition of the importance of natural flow regimes to sustain the ecological integrity of river systems has led to increased societal pressure on the hydropower industry to change plant operations to improve downstream aquatic ecosystems. However, a complete reinstatement of natural flow regimes is often unrealistic when balancing water needs for ecosystems, energy production, and other human uses. Thus, stakeholders must identify a prioritized subset of flow prescriptions that meet ecological objectives in light of realistic constraints. Yet, isolating aspects of flow regimes to restore downstream of hydropower facilities is among the greatest challenges of environmental flow science due, in part, to the sheer volume of available environmental flow tools in conjunction with complex negotiation-based regulatory procedures. Herein, we propose an organizational framework that structures information and existing flow paradigms into a staged process that assists stakeholders in implementing environmental flows for hydropower facilities. The framework identifies areas where regulations fall short of the needed scientific process, and provide suggestions for stakeholders to ameliorate those situations through advanced preparation. We highlight the strengths of existing flow paradigms in their application to hydropower settings and suggest when and where tools are most applicable. Our suggested framework increases the effectiveness and efficiency of the e-flow implementation process by rapidly establishing a knowledge base and decreasing uncertainty so more time can be devoted to filling knowledge gaps. Lastly, the framework provides the structure for a coordinated research agenda to further the science of environmental flows related to hydropower environments.

  18. Realising the potential for the protection of the environment by developing small hydro power

    Energy Technology Data Exchange (ETDEWEB)

    Stevenson, R.; Heal, A.

    2000-07-01

    The RAPPIDS project was set up to tackle the conflicts arising from the development of Small Hydro Power (SHP) in sensitive and fragile environments. The project was focused on Snowdonia National Park, which was identified as a conflict area in the UK. The aim was to develop a strategy to overcome these conflicts locally through: improving the understanding of market actors, of the effects of SHP on the environment; improving dialogue between market actors; initiating collaboration to analyse the environmental impacts and test innovative technological measures for sensitive SHP development; Identifying successful environmental measures and assessing their suitability for transfer to other regions; raising the awareness of market actors, of the environmental benefits of SHP. The project in the UK was mirrored in 2 regions of Europe, under the EU Altener programme, and lessons learnt were shared between regions. (author)

  19. Fragmentation of Andes-to-Amazon connectivity by hydropower dams.

    Science.gov (United States)

    Anderson, Elizabeth P; Jenkins, Clinton N; Heilpern, Sebastian; Maldonado-Ocampo, Javier A; Carvajal-Vallejos, Fernando M; Encalada, Andrea C; Rivadeneira, Juan Francisco; Hidalgo, Max; Cañas, Carlos M; Ortega, Hernan; Salcedo, Norma; Maldonado, Mabel; Tedesco, Pablo A

    2018-01-01

    Andes-to-Amazon river connectivity controls numerous natural and human systems in the greater Amazon. However, it is being rapidly altered by a wave of new hydropower development, the impacts of which have been previously underestimated. We document 142 dams existing or under construction and 160 proposed dams for rivers draining the Andean headwaters of the Amazon. Existing dams have fragmented the tributary networks of six of eight major Andean Amazon river basins. Proposed dams could result in significant losses in river connectivity in river mainstems of five of eight major systems-the Napo, Marañón, Ucayali, Beni, and Mamoré. With a newly reported 671 freshwater fish species inhabiting the Andean headwaters of the Amazon (>500 m), dams threaten previously unrecognized biodiversity, particularly among endemic and migratory species. Because Andean rivers contribute most of the sediment in the mainstem Amazon, losses in river connectivity translate to drastic alteration of river channel and floodplain geomorphology and associated ecosystem services.

  20. Small hydropower in Southern Africa – an overview of five countries in the region

    NARCIS (Netherlands)

    Jonker Klunne, Wim

    2013-01-01

    This paper looks at the status of small hydropower in Lesotho, Mozambique, South Africa, Swaziland and Zimbabwe. For each country, an overview will be given of the electricity sector and the role of hydropower, the potential for small hydropower and the expected future of this technology. Small

  1. Quantifying the Value of Hydropower in the Electric Grid. Final Report

    Energy Technology Data Exchange (ETDEWEB)

    Key, T. [Energy Efficiency and Renewable Energy (EERE), Washington, DC (United States)

    2013-02-01

    The report summarizes a 3-year DOE study focused on defining value of hydropower assets in a changing electric grid. The study looked at existing large hydropower operations in the U.S., models for different electricity futures, markets, costs of existing and new technologies as well as trends related to hydropower investments in other parts of the world.

  2. 78 FR 56872 - City of Barre, Vermont; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-09-16

    ..., Vermont; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and Soliciting... construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower Regulatory Efficiency Act of 2013 (HREA). The Nelson Street 17 kW...

  3. 78 FR 61958 - New England Hydropower Company, LLC; Notice of Preliminary Permit Application Accepted for Filing...

    Science.gov (United States)

    2013-10-08

    ... Hydropower Company, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications On August 20, 2013, the New England Hydropower Company... river are owned by the city of Meriden. Applicant Contact: Mr. Michael C. Kerr, New England Hydropower...

  4. 75 FR 18193 - Northern Illinois Hydropower, LLC; Notice of Application Accepted for Filing and Soliciting...

    Science.gov (United States)

    2010-04-09

    ... Illinois Hydropower, LLC; Notice of Application Accepted for Filing and Soliciting Motions To Intervene and... No.: 12626-002. c. Date filed: March 31, 2009. d. Applicant: Northern Illinois Hydropower, LLC. e... Power Act, 16 U.S.C. 791(a)-825(r). h. Applicant Contact: Damon Zdunich, Northern Illinois Hydropower...

  5. 78 FR 66355 - Pleasant Grove City, UT; Notice of Preliminary Determination of a Qualifying Conduit Hydropower...

    Science.gov (United States)

    2013-11-05

    ... City, UT; Notice of Preliminary Determination of a Qualifying Conduit Hydropower Facility and... Grove City, Utah (Pleasant Grove) filed a notice of intent to construct a qualifying conduit hydropower facility, pursuant to section 30 of the Federal Power Act, as amended by section 4 of the Hydropower...

  6. 75 FR 59707 - Coastal